seratrodast Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
thromboxane A2 receptor antagonists, antiasthmatics 2432 112665-43-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • seratrodast
  • seratodrast
  • bronica
has thromboxane A2 & prostaglandin H2 receptor antagonistic action
  • Molecular weight: 354.45
  • Formula: C22H26O4
  • CLOGP: 4.95
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 71.44
  • ALOGS: -4.99
  • ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC R03DX06 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Other systemic drugs for obstructive airway diseases
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D006727 Hormone Antagonists
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011448 Prostaglandin Antagonists
MeSH PA D019141 Respiratory System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.85 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Thromboxane A2 receptor GPCR IC50 8.13 CHEMBL

External reference:

IDSource
D01123 KEGG_DRUG
C0050339 UMLSCUI
CHEBI:32126 CHEBI
CHEMBL70972 ChEMBL_ID
2449 PUBCHEM_CID
C060230 MESH_SUPPLEMENTAL_RECORD_UI
7069 INN_ID
DB06739 DRUGBANK_ID
4U58JM421N UNII

Pharmaceutical products:

None