All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

omalizumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
humanized origin	4972	242138-07-4

Description:

Molecule

Description

Synonyms: omalizumab xolair rhuMab-E25 olizumab

An anti-IgE, recombinant, humanized monoclonal antibody which specifically binds to the C epsilon3 domain of IMMUNOGLOBULIN E, the site of high-affinity IgE receptor binding. It inhibits the binding of IgE to MAST CELLS and BASOPHILS to reduce the severity of the allergic response and is used in the management of persistent allergic ASTHMA. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
16	mg	P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
Oct. 25, 2005	EMA	Novartis Europharm Ltd
June 20, 2003	FDA	GENENTECH
Jan. 21, 2009	PMDA	Novartis Pharma K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
No adverse event	7393.18	15.28	3121	146839	64861	90413626
Urticaria	2922.89	15.28	3063	146897	309671	90168816
Wheezing	2157.29	15.28	2296	147664	235784	90242703
Anaphylactic reaction	2138.78	15.28	1492	148468	86032	90392455
Forced expiratory volume decreased	2108.61	15.28	652	149308	5156	90473331
Cough	1909.38	15.28	2680	147280	366282	90112205
Dyspnoea	1382.10	15.28	3866	146094	877089	89601398
Sputum discoloured	1328.66	15.28	657	149303	19734	90458753
Obstructive airways disorder	1308.75	15.28	703	149257	25166	90453321
Productive cough	1015.80	15.28	914	149046	76149	90402338
Asthma	930.29	15.28	1534	148426	240626	90237861
Angioedema	871.80	15.28	778	149182	64098	90414389
Chest discomfort	834.49	15.28	1085	148875	137280	90341207
Middle insomnia	821.41	15.28	446	149514	16305	90462182
Nasal congestion	662.16	15.28	752	149208	82662	90395825
Off label use	651.62	15.28	3555	146405	1098697	89379790
Blood immunoglobulin E increased	636.64	15.28	249	149711	4176	90474311
Respiratory tract infection	629.53	15.28	623	149337	58455	90420032
Sensitivity to weather change	606.76	15.28	296	149664	8618	90469869
Infusion related reaction	600.32	15.28	20	149940	416760	90061727
Malaise	577.20	15.28	2200	147760	583786	89894701
Pneumonia	575.65	15.28	2330	147630	635729	89842758
Heart rate increased	572.21	15.28	814	149146	112088	90366399
Nasal oedema	560.11	15.28	255	149705	6329	90472158
Oropharyngeal pain	552.40	15.28	809	149151	114378	90364109
Influenza	547.22	15.28	892	149068	138372	90340115
Pruritus	537.95	15.28	2039	147921	539486	89939001
Blood pressure systolic increased	537.64	15.28	569	149391	57776	90420711
Pemphigus	508.80	15.28	6	149954	326858	90151629
Contraindicated product administered	507.10	15.28	4	149956	320135	90158352
Synovitis	496.60	15.28	10	149950	329742	90148745
Asthmatic crisis	490.86	15.28	165	149795	1745	90476742
Acute kidney injury	448.76	15.28	19	149941	320368	90158119
Hand deformity	446.17	15.28	9	149951	296353	90182134
Nasal polyps	425.92	15.28	250	149710	10630	90467857
Toxicity to various agents	424.56	15.28	11	149949	287835	90190652
Skin plaque	421.82	15.28	241	149719	9734	90468753
Upper-airway cough syndrome	418.82	15.28	279	149681	14856	90463631
Glossodynia	416.99	15.28	30	149930	321749	90156738
Systemic lupus erythematosus	404.06	15.28	59	149901	361837	90116650
Throat tightness	402.64	15.28	357	149603	29127	90449360
Blood pressure increased	399.22	15.28	956	149004	196261	90282226
Pulmonary function test abnormal	386.53	15.28	152	149808	2587	90475900
Hepatic enzyme increased	386.50	15.28	66	149894	360670	90117817
Arthropathy	381.59	15.28	72	149888	366170	90112317
Rhinorrhoea	366.30	15.28	580	149380	87736	90390751
Anti-cyclic citrullinated peptide antibody positive	360.65	15.28	6	149954	236427	90242060
Hypoventilation	354.85	15.28	174	149786	5122	90473365
Oedema	351.88	15.28	920	149040	199375	90279112
Rales	349.45	15.28	254	149706	15573	90462914
Breath sounds abnormal	349.02	15.28	251	149709	15135	90463352
Drug intolerance	342.77	15.28	156	149804	447435	90031052
Pericarditis	339.27	15.28	29	149931	270122	90208365
Neutropenia	337.77	15.28	7	149953	224897	90253590
Helicobacter infection	337.03	15.28	8	149952	226842	90251645
Confusional state	336.43	15.28	110	149850	386095	90092392
Stomatitis	335.58	15.28	33	149927	274665	90203822
Joint swelling	326.57	15.28	216	149744	503084	89975403
Full blood count abnormal	317.86	15.28	346	149614	36251	90442236
Bronchitis	307.92	15.28	740	149220	152187	90326300
Rheumatoid arthritis	307.62	15.28	108	149852	362506	90115981
Illness	306.90	15.28	514	149446	81455	90397032
Drug interaction	306.34	15.28	46	149914	276407	90202080
Psoriatic arthropathy	305.46	15.28	18	149942	228317	90250170
Abdominal discomfort	298.79	15.28	213	149747	477115	90001372
Perfume sensitivity	295.99	15.28	96	149864	899	90477588
Impaired healing	291.72	15.28	26	149934	234173	90244314
Bronchopulmonary aspergillosis allergic	289.58	15.28	136	149824	3630	90474857
Secretion discharge	288.69	15.28	227	149733	15669	90462818
Folliculitis	283.13	15.28	13	149947	204340	90274147
Respiratory rate increased	274.55	15.28	221	149739	15780	90462707
Respiratory tract congestion	269.77	15.28	277	149683	27133	90451354
Wound	269.65	15.28	83	149877	302897	90175590
Diarrhoea	268.72	15.28	738	149222	938452	89540035
Liver injury	265.86	15.28	3	149957	170564	90307923
Rheumatoid factor positive	263.24	15.28	4	149956	171646	90306841
Rhinitis allergic	259.06	15.28	218	149742	16567	90461920
Seasonal allergy	255.20	15.28	248	149712	22735	90455752
Stress	249.97	15.28	468	149492	80927	90397560
Sneezing	246.59	15.28	275	149685	29594	90448893
Bronchospasm	246.11	15.28	232	149728	20477	90458010
Body temperature decreased	242.24	15.28	245	149715	23571	90454916
Drug hypersensitivity	240.59	15.28	1448	148512	462161	90016326
Pulmonary function test decreased	235.23	15.28	125	149835	4369	90474118
Irritable bowel syndrome	233.29	15.28	33	149927	207415	90271072
Forced vital capacity decreased	230.34	15.28	83	149877	1095	90477392
Erythema	227.34	15.28	864	149096	228382	90250105
Bronchiectasis	225.81	15.28	229	149731	22101	90456386
Completed suicide	224.06	15.28	3	149957	145055	90333432
Inappropriate schedule of product administration	220.85	15.28	646	149314	149287	90329200
Eosinophilic granulomatosis with polyangiitis	215.22	15.28	98	149862	2432	90476055
Nasopharyngitis	208.22	15.28	1267	148693	405837	90072650
Eye pruritus	204.00	15.28	246	149714	28781	90449706
Scratch	203.53	15.28	152	149808	9714	90468773
Peak expiratory flow rate decreased	203.48	15.28	65	149895	577	90477910
Hyponatraemia	201.07	15.28	4	149956	133534	90344953
Condition aggravated	199.04	15.28	431	149529	595114	89883373
Incorrect dose administered	197.98	15.28	417	149543	78513	90399974
C-reactive protein abnormal	195.24	15.28	3	149957	127426	90351061
Anaemia	190.19	15.28	182	149778	352620	90125867
Ear pruritus	189.63	15.28	126	149834	6677	90471810
Thrombocytopenia	189.60	15.28	55	149905	208670	90269817
Product use issue	188.81	15.28	161	149799	329758	90148729
Bronchial secretion retention	184.85	15.28	99	149861	3516	90474971
Chest X-ray abnormal	178.71	15.28	109	149851	4973	90473514
Anaphylactic shock	178.04	15.28	240	149720	31377	90447110
Dysphonia	176.83	15.28	349	149611	62735	90415752
Throat irritation	176.43	15.28	301	149659	48394	90430093
Allergy to animal	176.06	15.28	75	149885	1579	90476908
Myalgia	174.33	15.28	661	149299	174464	90304023
Treatment failure	173.07	15.28	149	149811	303779	90174708
White blood cell count decreased	171.45	15.28	34	149926	167075	90311412
Sinus pain	170.32	15.28	108	149852	5281	90473206
Weight decreased	169.89	15.28	1143	148817	378767	90099720
Dust allergy	168.08	15.28	60	149900	769	90477718
Eosinophil count increased	167.92	15.28	153	149807	12928	90465559
Swelling face	167.22	15.28	397	149563	80955	90397532
Lip swelling	164.75	15.28	257	149703	38353	90440134
Hypokalaemia	164.72	15.28	14	149946	131102	90347385
Humidity intolerance	164.50	15.28	50	149910	370	90478117
Pharyngeal swelling	163.53	15.28	134	149826	9810	90468677
Aphonia	161.89	15.28	146	149814	12173	90466314
Malignant neoplasm progression	161.71	15.28	3	149957	106867	90371620
Joint range of motion decreased	161.17	15.28	18	149942	135625	90342862
Viral infection	160.72	15.28	264	149696	41150	90437337
Dyspnoea exertional	159.79	15.28	363	149597	71925	90406562
Animal scratch	159.19	15.28	72	149888	1758	90476729
Platelet count decreased	158.23	15.28	20	149940	136949	90341538
Therapeutic product effect decreased	156.91	15.28	137	149823	277434	90201053
Reversible airways obstruction	156.76	15.28	73	149887	1910	90476577
Paranasal sinus discomfort	156.36	15.28	108	149852	6102	90472385
Vital capacity decreased	153.29	15.28	70	149890	1749	90476738
Facet joint syndrome	147.91	15.28	3	149957	98386	90380101
Urinary tract discomfort	147.90	15.28	56	149904	856	90477631
Exposure to allergen	147.24	15.28	49	149911	501	90477986
Lacrimation increased	147.18	15.28	202	149758	26860	90451627
Influenza like illness	141.07	15.28	370	149590	80241	90398246
Urticaria thermal	140.75	15.28	47	149913	486	90478001
Dehydration	140.67	15.28	73	149887	194374	90284113
Blood cholesterol increased	140.54	15.28	85	149875	207927	90270560
Intentional overdose	140.50	15.28	3	149957	93831	90384656
Decreased appetite	139.80	15.28	256	149704	376284	90102203
Smoke sensitivity	139.13	15.28	46	149914	460	90478027
Nausea	138.49	15.28	1175	148785	1109141	89369346
Constipation	138.25	15.28	156	149804	280239	90198248
Gastrointestinal disorder	137.59	15.28	133	149827	256554	90221933
Total lung capacity decreased	137.57	15.28	83	149877	3712	90474775
General physical health deterioration	134.01	15.28	239	149721	354876	90123611
Adverse event	133.57	15.28	18	149942	117400	90361087
Feeling abnormal	132.99	15.28	589	149371	166646	90311841
Prescribed overdose	132.65	15.28	7	149953	97618	90380869
Disease progression	132.06	15.28	47	149913	156568	90321919
C-reactive protein increased	131.36	15.28	68	149892	181321	90297166
Lip dry	128.97	15.28	10	149950	100945	90377542
Nasal discharge discolouration	128.91	15.28	72	149888	2781	90475706
Liver disorder	127.95	15.28	23	149937	121246	90357241
Sinus congestion	127.53	15.28	190	149770	27234	90451253
Blood lactic acid increased	127.27	15.28	110	149850	8668	90469819
Delirium	126.14	15.28	13	149947	104346	90374141
Lower respiratory tract congestion	125.80	15.28	75	149885	3281	90475206
Alveolar osteitis	124.05	15.28	53	149907	1124	90477363
Mechanical urticaria	123.54	15.28	44	149916	560	90477927
Injury	122.04	15.28	89	149871	197260	90281227
Sputum culture positive	121.69	15.28	64	149896	2189	90476298
Breast cancer stage III	121.58	15.28	4	149956	84443	90394044
Peripheral venous disease	120.73	15.28	4	149956	83917	90394570
Injection site pain	118.46	15.28	585	149375	173114	90305373
Hypercholesterolaemia	118.32	15.28	14	149946	100878	90377609
Musculoskeletal stiffness	116.94	15.28	194	149766	296338	90182149
Swollen tongue	116.61	15.28	244	149716	45712	90432775
Osteoarthritis	115.01	15.28	93	149867	195637	90282850
Eye swelling	114.93	15.28	188	149772	29198	90449289
Hypotension	114.83	15.28	228	149732	325169	90153318
Tunnel vision	114.29	15.28	56	149904	1645	90476842
Ear congestion	113.84	15.28	71	149889	3371	90475116
Alanine aminotransferase increased	109.62	15.28	30	149930	118308	90360179
Hip arthroplasty	108.35	15.28	4	149956	76204	90402283
Night sweats	106.26	15.28	40	149920	128726	90349761
Temperature intolerance	104.89	15.28	114	149846	11916	90466571
Drug-induced liver injury	104.76	15.28	13	149947	90305	90388182
Fibromyalgia	104.68	15.28	112	149848	206157	90272330
Leukopenia	104.31	15.28	20	149940	100690	90377797
Knee arthroplasty	104.15	15.28	9	149951	83173	90395314
Neuropathy peripheral	102.70	15.28	49	149911	136921	90341566
Pulmonary mass	100.47	15.28	175	149785	28597	90449890
Drug abuse	100.19	15.28	10	149950	82337	90396150
Rubber sensitivity	100.14	15.28	61	149899	2776	90475711
Septic shock	97.89	15.28	12	149948	84148	90394339
Overdose	97.66	15.28	71	149889	157638	90320849
Eosinophilia	95.06	15.28	170	149790	28363	90450124
Serum sickness	94.87	15.28	64	149896	3478	90475009
Infection	94.02	15.28	297	149663	361797	90116690
Chronic spontaneous urticaria	93.50	15.28	50	149910	1770	90476717
Gastrointestinal haemorrhage	93.30	15.28	18	149942	90230	90388257
Live birth	92.70	15.28	11	149949	79096	90399391
Anaphylactoid reaction	92.52	15.28	69	149891	4399	90474088
Throat clearing	92.40	15.28	65	149895	3782	90474705
Wound secretion	92.20	15.28	72	149888	4918	90473569
Spirometry abnormal	91.94	15.28	29	149931	246	90478241
Aspartate aminotransferase increased	91.84	15.28	28	149932	102909	90375578
Hypersensitivity	91.71	15.28	1152	148808	453525	90024962
Neutrophil count decreased	91.61	15.28	7	149953	71525	90406962
Bronchial obstruction	91.29	15.28	48	149912	1641	90476846
Wound infection	91.29	15.28	31	149929	106371	90372116
Blood pressure decreased	91.04	15.28	302	149658	74593	90403894
Pharyngeal oedema	90.75	15.28	113	149847	13658	90464829
Quality of life decreased	90.55	15.28	105	149855	11784	90466703
Injection site scab	90.10	15.28	36	149924	640	90477847
Bursitis	90.02	15.28	53	149907	131601	90346886
Product availability issue	88.07	15.28	83	149877	7321	90471166
Sciatica	87.92	15.28	29	149931	101353	90377134
Lower limb fracture	87.80	15.28	17	149943	84996	90393491
Mastocytosis	87.58	15.28	39	149921	917	90477570
Rhinitis	87.26	15.28	110	149850	13462	90465025
Atrial fibrillation	86.91	15.28	57	149903	133554	90344933
Bladder pain	86.87	15.28	55	149905	2682	90475805
Chest pain	86.85	15.28	859	149101	318786	90159701
Respiratory tract inflammation	86.06	15.28	34	149926	586	90477901
Cardiac failure congestive	85.99	15.28	28	149932	98666	90379821
Frustration tolerance decreased	85.39	15.28	84	149876	7812	90470675
Mast cell activation syndrome	85.30	15.28	45	149915	1549	90476938
Eczema	84.77	15.28	235	149725	52635	90425852
Blister	84.59	15.28	185	149775	254813	90223674
Sepsis	84.34	15.28	104	149856	179710	90298777
Hyperkalaemia	84.21	15.28	6	149954	64958	90413529
Dry mouth	83.69	15.28	109	149851	183950	90294537
Increased bronchial secretion	83.02	15.28	49	149911	2104	90476383
Bradycardia	82.01	15.28	19	149941	83828	90394659
Restrictive pulmonary disease	81.36	15.28	50	149910	2312	90476175
Total lung capacity increased	81.18	15.28	67	149893	4954	90473533
Vasculitis	80.51	15.28	139	149821	22554	90455933
Electrocardiogram QT prolonged	80.31	15.28	12	149948	72444	90406043
Idiopathic urticaria	80.03	15.28	28	149932	337	90478150
Medication error	79.27	15.28	21	149939	84631	90393856
Food allergy	78.80	15.28	147	149813	25331	90453156
Depressed level of consciousness	78.53	15.28	13	149947	72771	90405716
Blepharospasm	78.51	15.28	3	149957	55442	90423045
Cryopyrin associated periodic syndrome	78.32	15.28	31	149929	537	90477950
Grip strength decreased	77.65	15.28	28	149932	92548	90385939
Psoriasis	77.47	15.28	78	149882	147676	90330811
Symptom recurrence	77.24	15.28	59	149901	3900	90474587
Cold urticaria	76.91	15.28	26	149934	280	90478207
Multiple organ dysfunction syndrome	76.48	15.28	11	149949	68325	90410162
Polymyalgia rheumatica	75.48	15.28	64	149896	4913	90473574
Conjunctivitis allergic	75.27	15.28	39	149921	1293	90477194
Pregnancy	75.23	15.28	250	149710	61797	90416690
Sensation of foreign body	75.02	15.28	71	149889	6295	90472192
Dyspepsia	75.01	15.28	133	149827	198027	90280460
Respiratory disorder	74.92	15.28	257	149703	64559	90413928
Breast cancer	74.67	15.28	227	149733	53534	90424953
Blood immunoglobulin E decreased	74.66	15.28	23	149937	179	90478308
Status asthmaticus	73.89	15.28	34	149926	865	90477622
Headache	73.83	15.28	1908	148052	860838	89617649
Taste disorder	73.52	15.28	8	149952	61538	90416949
Renal failure	72.36	15.28	66	149894	130941	90347546
Oropharyngeal discomfort	72.20	15.28	76	149884	7659	90470828
Ill-defined disorder	71.89	15.28	122	149838	184769	90293718
Hypokinesia	70.48	15.28	107	149853	15590	90462897
Suicide attempt	70.04	15.28	19	149941	75380	90403107
Inflammation	69.29	15.28	118	149842	178474	90300013
Frequent bowel movements	69.04	15.28	7	149953	56928	90421559
Rhabdomyolysis	68.62	15.28	4	149956	51252	90427235
Forced expiratory flow decreased	68.34	15.28	19	149941	98	90478389
Hypoacusis	67.33	15.28	145	149815	27705	90450782
Hepatitis	67.28	15.28	17	149943	70722	90407765
Abortion spontaneous	66.60	15.28	219	149741	53837	90424650
Pulmonary congestion	66.30	15.28	117	149843	19316	90459171
Ascites	66.20	15.28	3	149957	47737	90430750
Rectal haemorrhage	66.12	15.28	27	149933	82717	90395770
Burning sensation	65.98	15.28	243	149717	63209	90415278
Amnesia	65.68	15.28	50	149910	108455	90370032
Wound complication	65.66	15.28	58	149902	4705	90473782
International normalised ratio increased	65.53	15.28	3	149957	47313	90431174
Cognitive disorder	65.40	15.28	17	149943	69390	90409097
Papule	64.88	15.28	73	149887	7929	90470558
Gait inability	64.26	15.28	89	149871	146367	90332120
Hypertension	64.25	15.28	468	149492	457064	90021423
Platelet count increased	64.07	15.28	120	149840	20739	90457748
Hypoaesthesia oral	63.99	15.28	102	149858	15498	90462989
Onychomadesis	63.43	15.28	3	149957	45995	90432492
Red blood cell sedimentation rate increased	62.75	15.28	29	149931	82566	90395921
Discomfort	62.42	15.28	238	149722	274097	90204390
Hospitalisation	62.29	15.28	72	149888	128028	90350459
Multiple sclerosis relapse	61.97	15.28	7	149953	52298	90426189
Death	61.25	15.28	473	149487	456078	90022409
Interstitial lung disease	60.94	15.28	25	149935	76380	90402107
Multiple allergies	60.72	15.28	98	149862	15048	90463439
Epilepsy	60.71	15.28	30	149930	82176	90396311
Chills	60.58	15.28	400	149560	131581	90346906
Blood iron decreased	59.82	15.28	107	149853	17852	90460635
Adverse drug reaction	59.59	15.28	63	149897	116638	90361849
Mouth swelling	58.95	15.28	59	149901	5603	90472884
Lung opacity	58.82	15.28	61	149899	6041	90472446
Food intolerance	58.81	15.28	50	149910	3852	90474635
Urticaria chronic	58.74	15.28	28	149932	773	90477714
Hallucination	58.73	15.28	18	149942	65941	90412546
Abdominal pain upper	58.71	15.28	317	149643	332357	90146130
Decompression sickness	58.57	15.28	17	149943	105	90478382
Depression	58.41	15.28	277	149683	300324	90178163
Bronchial wall thickening	58.26	15.28	39	149921	2092	90476395
Lung diffusion test decreased	57.76	15.28	28	149932	803	90477684
Dyspnoea at rest	57.54	15.28	54	149906	4737	90473750
Nasal pruritus	57.40	15.28	27	149933	723	90477764
Wrist fracture	57.13	15.28	97	149863	15527	90462960
Paraesthesia oral	57.09	15.28	147	149813	31512	90446975
Type 2 diabetes mellitus	56.81	15.28	161	149799	203083	90275404
Memory impairment	56.81	15.28	154	149806	197090	90281397
Lactic acidosis	56.76	15.28	8	149952	50455	90428032
Fluid retention	56.71	15.28	38	149922	88053	90390434
Injection site discomfort	56.58	15.28	59	149901	5881	90472606
Blood bilirubin increased	56.39	15.28	4	149956	43466	90435021
Exostosis	56.20	15.28	10	149950	53124	90425363
Crepitations	55.73	15.28	71	149889	8781	90469706
Feeling hot	55.48	15.28	266	149694	77742	90400745
Feeling cold	55.29	15.28	133	149827	27332	90451155
Nail disorder	54.65	15.28	15	149945	59052	90419435
Colitis ulcerative	54.47	15.28	16	149944	60250	90418237
Coma	54.41	15.28	26	149934	72606	90405881
Lupus-like syndrome	54.34	15.28	8	149952	48838	90429649
Needle issue	52.94	15.28	88	149872	13846	90464641
FEV1/FVC ratio decreased	52.91	15.28	17	149943	154	90478333
Auditory neuropathy spectrum disorder	52.77	15.28	12	149948	21	90478466
Renal impairment	52.62	15.28	58	149902	105363	90373124
Intentional product use issue	52.06	15.28	184	149776	216708	90261779
Foot deformity	51.82	15.28	17	149943	59634	90418853
Hepatic cirrhosis	51.59	15.28	20	149940	63233	90415254
Cardiac arrest	50.99	15.28	59	149901	104876	90373611
Respiratory failure	50.92	15.28	73	149887	118345	90360142
Asthma-chronic obstructive pulmonary disease overlap syndrome	50.91	15.28	51	149909	4848	90473639
Myopathy	50.86	15.28	85	149875	13433	90465054
Liver function test abnormal	50.77	15.28	11	149949	50834	90427653
Hepatic failure	50.55	15.28	4	149956	39724	90438763
Mental status changes	50.44	15.28	7	149953	44672	90433815
Cardio-respiratory arrest	49.81	15.28	21	149939	63119	90415368
Hypocalcaemia	49.37	15.28	6	149954	42362	90436125
Increased viscosity of bronchial secretion	49.32	15.28	20	149940	370	90478117
Vaccination site pain	49.27	15.28	20	149940	371	90478116
Sinusitis	49.07	15.28	819	149141	342269	90136218
Hyperventilation	48.87	15.28	58	149902	6670	90471817
Ear pain	48.70	15.28	207	149753	57495	90420992
Laboratory test abnormal	48.59	15.28	6	149954	41848	90436639
Neonatal hypoacusis	48.46	15.28	11	149949	19	90478468
Hepatotoxicity	47.68	15.28	9	149951	45833	90432654
Expiratory reserve volume decreased	47.57	15.28	12	149948	39	90478448
Mobility decreased	47.56	15.28	233	149727	250501	90227986
Ligament sprain	47.37	15.28	86	149874	14513	90463974
Pulmonary pain	47.29	15.28	50	149910	5064	90473423
Disability	46.92	15.28	6	149954	40739	90437748
Walking aid user	46.84	15.28	3	149957	35503	90442984
Colitis	46.62	15.28	29	149931	69913	90408574
Forced expiratory volume increased	46.61	15.28	13	149947	68	90478419
Periorbital swelling	46.32	15.28	48	149912	4750	90473737
Urticarial vasculitis	46.20	15.28	26	149934	1019	90477468
Head deformity	46.19	15.28	15	149945	141	90478346
Joint stiffness	45.92	15.28	37	149923	78005	90400482
Skin ulcer	45.80	15.28	13	149947	50062	90428425
Flushing	45.44	15.28	276	149684	88215	90390272
Blood alkaline phosphatase increased	44.87	15.28	12	149948	48067	90430420
Hypercalcaemia	44.85	15.28	3	149957	34237	90444250
Plasma cell myeloma	44.70	15.28	7	149953	40821	90437666
Laryngeal oedema	44.60	15.28	56	149904	6825	90471662
Hereditary angioedema	43.70	15.28	65	149895	9300	90469187
Ear discomfort	43.65	15.28	68	149892	10132	90468355
Unresponsive to stimuli	42.97	15.28	6	149954	38115	90440372
Melaena	42.92	15.28	4	149956	34793	90443694
Hepatic function abnormal	42.36	15.28	12	149948	46276	90432211
Migraine	42.03	15.28	491	149469	189901	90288586
Limb injury	41.85	15.28	131	149829	31377	90447110
Choking	41.76	15.28	73	149887	11960	90466527
Otorrhoea	41.18	15.28	30	149930	1845	90476642
Choking sensation	40.90	15.28	41	149919	3901	90474586
Agranulocytosis	40.68	15.28	5	149955	34997	90443490
Pneumonia aspiration	40.59	15.28	9	149951	40931	90437556
Blood calcium increased	40.36	15.28	72	149888	11986	90466501
Nervousness	40.20	15.28	136	149824	33920	90444567
Sinus disorder	40.16	15.28	137	149823	34310	90444177
Muscle tension dysphonia	40.12	15.28	16	149944	283	90478204
Sarcoidosis	40.01	15.28	67	149893	10606	90467881
Orthostatic hypotension	39.88	15.28	10	149950	41817	90436670
Diabetes mellitus	39.65	15.28	212	149748	64663	90413824
Treatment noncompliance	39.54	15.28	18	149942	51709	90426778
Accident	39.46	15.28	53	149907	6901	90471586
Chronic kidney disease	39.10	15.28	17	149943	50174	90428313
Tryptase increased	39.10	15.28	19	149941	548	90477939
Chronic obstructive pulmonary disease	39.00	15.28	232	149728	73597	90404890
Peak expiratory flow rate abnormal	38.55	15.28	12	149948	97	90478390
Wrong technique in product usage process	38.52	15.28	226	149734	71345	90407142
Body temperature abnormal	38.37	15.28	33	149927	2582	90475905
Tympanosclerosis	38.31	15.28	11	149949	65	90478422
Skin lesion	37.92	15.28	142	149818	37223	90441264
Pharyngeal disorder	37.80	15.28	32	149928	2451	90476036
Cystic fibrosis	37.28	15.28	39	149921	3902	90474585
Respiratory rate decreased	36.93	15.28	39	149921	3944	90474543
Oral pruritus	36.87	15.28	34	149926	2917	90475570
Syringe issue	36.78	15.28	39	149921	3963	90474524
Body temperature increased	36.66	15.28	159	149801	44551	90433936
Loss of personal independence in daily activities	36.43	15.28	110	149850	135995	90342492
Skin sensitisation	36.28	15.28	22	149938	993	90477494
Drug withdrawal syndrome	36.25	15.28	3	149957	28720	90449767
Femur fracture	35.28	15.28	16	149944	46066	90432421
Full blood count decreased	35.10	15.28	4	149956	29685	90448802
Pleural effusion	34.88	15.28	84	149876	111907	90366580
Ear swelling	34.24	15.28	27	149933	1870	90476617
Osteonecrosis of jaw	34.22	15.28	11	149949	39092	90439395
Respiratory fume inhalation disorder	33.81	15.28	12	149948	151	90478336
Concomitant disease aggravated	33.81	15.28	65	149895	11453	90467034
Obesity	33.77	15.28	78	149882	105429	90373058
Functional residual capacity decreased	33.63	15.28	10	149950	68	90478419
Blood immunoglobulin E abnormal	33.55	15.28	8	149952	19	90478468
Upper airway obstruction	33.41	15.28	21	149939	1011	90477476
Autoimmune disorder	33.29	15.28	47	149913	76697	90401790
Fear of disease	33.29	15.28	24	149936	1452	90477035
Haematochezia	33.25	15.28	41	149919	70872	90407615
Pulmonary fibrosis	33.19	15.28	81	149879	107422	90371065
Device dislocation	33.13	15.28	6	149954	31476	90447011
Accidental overdose	32.95	15.28	4	149956	28269	90450218
Rhonchi	32.80	15.28	32	149928	2946	90475541
Forced expiratory volume abnormal	32.75	15.28	11	149949	116	90478371
Cystic fibrosis pancreatic	32.60	15.28	9	149951	45	90478442
Fibromuscular dysplasia	32.46	15.28	14	149946	304	90478183
Pulmonary arterial hypertension	32.33	15.28	3	149957	26184	90452303
Device defective	32.09	15.28	34	149926	3452	90475035
Lung hyperinflation	32.00	15.28	23	149937	1385	90477102
Anxiety	31.78	15.28	703	149257	309069	90169418
Rash maculo-papular	31.67	15.28	14	149946	40919	90437568
Tongue oedema	31.61	15.28	42	149918	5412	90473075
Heart rate abnormal	31.61	15.28	44	149916	5927	90472560
Metastases to liver	31.40	15.28	5	149955	28802	90449685
Functional residual capacity increased	31.28	15.28	10	149950	89	90478398
Blood calcium decreased	31.23	15.28	6	149954	30176	90448311
Vascular access site thrombosis	31.09	15.28	9	149951	55	90478432
Eye allergy	31.08	15.28	22	149938	1293	90477194
Macular degeneration	30.97	15.28	12	149948	37958	90440529
Gamma-glutamyltransferase increased	30.95	15.28	12	149948	37940	90440547
Psychotic disorder	30.69	15.28	7	149953	31223	90447264
Urinary retention	30.67	15.28	12	149948	37732	90440755
Injection site bruising	30.66	15.28	169	149791	52138	90426349
Local reaction	30.39	15.28	18	149942	778	90477709
Bacterial disease carrier	30.38	15.28	25	149935	1841	90476646
Calculus urinary	30.29	15.28	24	149936	1674	90476813
Therapy non-responder	30.17	15.28	120	149840	136584	90341903
Nasal inflammation	29.78	15.28	17	149943	685	90477802
Injection related reaction	29.77	15.28	20	149940	1079	90477408
Serum sickness-like reaction	29.77	15.28	16	149944	572	90477915
Hyposmia	29.58	15.28	19	149941	950	90477537
Blood urea increased	29.52	15.28	7	149953	30406	90448081
Drug reaction with eosinophilia and systemic symptoms	29.52	15.28	17	149943	42741	90435746
Respiratory distress	29.29	15.28	135	149825	38811	90439676
Haemoptysis	29.26	15.28	121	149839	33199	90445288
Hypervolaemia	29.05	15.28	9	149951	32748	90445739
Allergy test positive	28.91	15.28	17	149943	725	90477762
Sinus headache	28.87	15.28	44	149916	6432	90472055
Road traffic accident	28.79	15.28	87	149873	107539	90370948
Sputum culture	28.61	15.28	13	149947	321	90478166
Movement disorder	28.39	15.28	109	149851	28910	90449577
Hypoglycaemia	28.15	15.28	45	149915	69803	90408684
Musculoskeletal pain	28.11	15.28	167	149793	171084	90307403
Intentional self-injury	27.99	15.28	7	149953	29327	90449160
Gastrooesophageal reflux disease	27.90	15.28	408	149552	165929	90312558
Vascular access site infection	27.87	15.28	9	149951	83	90478404
Reaction to azo-dyes	27.69	15.28	7	149953	23	90478464
Finger deformity	27.50	15.28	10	149950	32887	90445600
Sense of oppression	27.39	15.28	19	149941	1081	90477406
Injection site erythema	27.32	15.28	266	149694	98236	90380251
Skin laceration	27.30	15.28	100	149860	25935	90452552
Swelling	27.15	15.28	509	149451	418549	90059938
Lung neoplasm malignant	26.96	15.28	95	149865	24178	90454309
Mite allergy	26.96	15.28	17	149943	823	90477664
Tooth disorder	26.76	15.28	9	149951	31081	90447406
Ligament rupture	26.71	15.28	32	149928	3716	90474771
Pain in jaw	26.70	15.28	24	149936	47961	90430526
Oropharyngeal spasm	26.64	15.28	12	149948	290	90478197
Pancreatitis acute	26.44	15.28	10	149950	32105	90446382
Bronchomalacia	26.43	15.28	11	149949	218	90478269
Stevens-Johnson syndrome	26.18	15.28	8	149952	29368	90449119
Cytomegalovirus infection	26.07	15.28	6	149954	26596	90451891
Haemoglobin decreased	26.02	15.28	159	149801	161797	90316690
Red blood cell count decreased	26.01	15.28	23	149937	46328	90432159
Respiration abnormal	25.95	15.28	47	149913	7916	90470571
Increased upper airway secretion	25.95	15.28	32	149928	3829	90474658
Oropharyngitis fungal	25.78	15.28	8	149952	64	90478423
Lymphocyte count decreased	25.56	15.28	13	149947	35037	90443450
Aphasia	25.56	15.28	20	149940	42792	90435695
Skin burning sensation	25.55	15.28	81	149879	19530	90458957
Photosensitivity reaction	25.49	15.28	76	149884	17731	90460756
Aspiration	25.39	15.28	70	149890	15623	90462864
Drug dependence	25.36	15.28	106	149854	29221	90449266
Injection site hypoaesthesia	25.29	15.28	15	149945	650	90477837
Acute respiratory distress syndrome	25.23	15.28	8	149952	28678	90449809
Hypoaesthesia	25.17	15.28	367	149593	313843	90164644
Urticaria pressure	25.14	15.28	8	149952	70	90478417
Panic attack	24.95	15.28	98	149862	26267	90452220
Nocturnal dyspnoea	24.93	15.28	20	149940	1420	90477067
Suffocation feeling	24.82	15.28	21	149939	1607	90476880
Dyskinesia	24.55	15.28	15	149945	36519	90441968
Lower respiratory tract infection	24.49	15.28	565	149395	250094	90228393
Urinary tract infection	24.47	15.28	357	149603	305275	90173212
Claustrophobia	24.20	15.28	19	149941	1308	90477179
Red blood cell count increased	24.17	15.28	30	149930	3613	90474874
Alopecia	24.14	15.28	629	149331	494442	89984045
Type I hypersensitivity	24.09	15.28	32	149928	4123	90474364
Solar urticaria	24.02	15.28	8	149952	82	90478405
Visual impairment	23.94	15.28	125	149835	132240	90346247
Speech disorder	23.92	15.28	143	149817	45442	90433045
Intercepted product storage error	23.86	15.28	13	149947	478	90478009
Coronary artery disease	23.74	15.28	13	149947	33610	90444877
Mental disorder	23.55	15.28	111	149849	32207	90446280
Fall	23.53	15.28	612	149348	481198	89997289
Forearm fracture	23.51	15.28	14	149946	611	90477876
Terminal insomnia	23.47	15.28	18	149942	1197	90477290
Coagulopathy	23.33	15.28	5	149955	23284	90455203
Injection site swelling	23.13	15.28	174	149786	59665	90418822
Laryngospasm	23.01	15.28	28	149932	3305	90475182
Blood creatinine increased	23.00	15.28	88	149872	101298	90377189
Limb discomfort	23.00	15.28	124	149836	37936	90440551
Tongue pruritus	22.86	15.28	15	149945	778	90477709
Upper limb fracture	22.73	15.28	83	149877	21495	90456992
Sleep disorder	22.54	15.28	214	149746	197816	90280671
Generalised tonic-clonic seizure	22.54	15.28	15	149945	34888	90443599
Clostridium difficile colitis	22.52	15.28	8	149952	26698	90451789
Deep vein thrombosis	22.46	15.28	77	149883	91543	90386944
Nasal mucosal disorder	22.44	15.28	21	149939	1836	90476651
Sedation	22.42	15.28	28	149932	48143	90430344
Product storage error	22.29	15.28	79	149881	20162	90458325
Blood urine present	22.18	15.28	71	149889	17207	90461280
Vaginal discharge	22.09	15.28	3	149957	19461	90459026
Arthritis	22.08	15.28	174	149786	167141	90311346
Pleural rub	22.03	15.28	7	149953	61	90478426
Allergy to chemicals	21.90	15.28	29	149931	3725	90474762
Pigmentation disorder	21.84	15.28	37	149923	5912	90472575
General physical condition abnormal	21.77	15.28	34	149926	5077	90473410
Coeliac disease	21.76	15.28	25	149935	44585	90433902
Serum amyloid A protein increased	21.74	15.28	14	149946	703	90477784
Eosinophil count abnormal	21.66	15.28	15	149945	851	90477636
Pulmonary thrombosis	21.47	15.28	49	149911	9733	90468754
Exercise tolerance decreased	21.42	15.28	42	149918	7509	90470978
Injection site urticaria	21.32	15.28	72	149888	17939	90460548
Device related infection	21.28	15.28	8	149952	25778	90452709
Abdominal pain	21.12	15.28	496	149464	395225	90083262
Altered state of consciousness	21.12	15.28	13	149947	31519	90446968
Pharyngitis	21.11	15.28	82	149878	21865	90456622
Dry throat	21.05	15.28	43	149917	7917	90470570
Pneumococcal infection	20.94	15.28	17	149943	1228	90477259
Vocal cord dysfunction	20.93	15.28	15	149945	899	90477588
Blood potassium decreased	20.89	15.28	143	149817	47584	90430903
Haematocrit decreased	20.89	15.28	23	149937	41809	90436678
Lymphopenia	20.81	15.28	6	149954	22875	90455612
Atopy	20.78	15.28	10	149950	282	90478205
Cerebral infarction	20.73	15.28	9	149951	26587	90451900
Tubulointerstitial nephritis	20.69	15.28	8	149952	25335	90453152
Radiculopathy	20.65	15.28	3	149957	18502	90459985
Labyrinthitis	20.61	15.28	24	149936	2705	90475782
Drug eruption	20.56	15.28	17	149943	35390	90443097
Pulmonary hypertension	20.55	15.28	24	149936	42499	90435988
Respiratory moniliasis	20.43	15.28	9	149951	206	90478281
Histamine level increased	20.41	15.28	6	149954	39	90478448
Small intestinal obstruction	20.39	15.28	5	149955	21229	90457258
Urosepsis	20.39	15.28	5	149955	21227	90457260
Flatulence	20.37	15.28	23	149937	41344	90437143
Immunisation reaction	20.35	15.28	14	149946	786	90477701
Decreased activity	20.20	15.28	43	149917	8149	90470338
Sputum retention	20.18	15.28	13	149947	653	90477834
Stab wound	20.18	15.28	7	149953	82	90478405
Nasal disorder	20.09	15.28	26	149934	3266	90475221
Epiglottitis	20.04	15.28	12	149948	529	90477958
Bacteraemia	20.00	15.28	6	149954	22294	90456193
Type III immune complex mediated reaction	20.00	15.28	11	149949	412	90478075
Ligament pain	19.96	15.28	9	149951	218	90478269
Bruxism	19.95	15.28	30	149930	4333	90474154
Upper respiratory tract congestion	19.92	15.28	22	149938	2340	90476147
Ventricular tachycardia	19.84	15.28	8	149952	24700	90453787
Allergy to plants	19.73	15.28	14	149946	826	90477661
Papulopustular rosacea	19.67	15.28	6	149954	45	90478442
Weight increased	19.57	15.28	862	149098	417065	90061422
Injection site oedema	19.52	15.28	19	149941	1744	90476743
Joint injury	19.46	15.28	106	149854	32558	90445929
Maternal exposure before pregnancy	19.13	15.28	51	149909	11162	90467325
Cytopenia	19.08	15.28	3	149957	17446	90461041
Pancreatitis	18.99	15.28	56	149904	69770	90408717
Nerve compression	18.99	15.28	49	149911	10517	90467970
Oxygen saturation decreased	18.96	15.28	266	149694	107217	90371270
Lipohypertrophy	18.95	15.28	13	149947	726	90477761
Lipoma	18.87	15.28	24	149936	2962	90475525
Muscle spasms	18.86	15.28	298	149662	251585	90226902
Agitation	18.85	15.28	53	149907	67045	90411442
Cardiac infection	18.84	15.28	12	149948	591	90477896
Suicidal ideation	18.83	15.28	61	149899	73794	90404693
Lymphadenopathy	18.78	15.28	135	149825	45640	90432847
Pertussis	18.76	15.28	14	149946	893	90477594
Administration site erythema	18.74	15.28	14	149946	895	90477592
Sinonasal obstruction	18.70	15.28	9	149951	254	90478233
Secondary hypogonadism	18.58	15.28	8	149952	173	90478314
Electrolyte imbalance	18.56	15.28	8	149952	23737	90454750
Ehlers-Danlos syndrome	18.44	15.28	10	149950	364	90478123
Skin discolouration	18.35	15.28	131	149829	44184	90434303
Blood lactate dehydrogenase increased	18.35	15.28	10	149950	25922	90452565
Oropharyngeal swelling	18.35	15.28	14	149946	924	90477563
Cerebral haemorrhage	18.34	15.28	18	149942	34504	90443983
Product use in unapproved indication	18.33	15.28	420	149540	335816	90142671
Skin necrosis	18.33	15.28	3	149957	16938	90461549
Injection site pruritus	18.32	15.28	152	149808	53682	90424805
Caffeine allergy	18.28	15.28	5	149955	24	90478463
Product dose omission issue	18.23	15.28	621	149339	291066	90187421
Pulmonary oedema	18.21	15.28	48	149912	62032	90416455
Seizure	18.21	15.28	163	149797	152466	90326021
Mental impairment	18.00	15.28	3	149957	16717	90461770
Nasal septum deviation	17.97	15.28	19	149941	1924	90476563
Selective IgA immunodeficiency	17.95	15.28	5	149955	26	90478461
Blood potassium increased	17.87	15.28	6	149954	20743	90457744
Laryngitis fungal	17.85	15.28	8	149952	191	90478296
Ileus	17.75	15.28	3	149957	16543	90461944
Pharyngeal paraesthesia	17.72	15.28	24	149936	3150	90475337
Dizziness	17.70	15.28	1166	148794	588118	89890369
Jaw fracture	17.68	15.28	22	149938	2656	90475831
Drug tolerance	17.64	15.28	4	149956	17912	90460575
Exposure during pregnancy	17.53	15.28	283	149677	238127	90240360
Sinus tachycardia	17.43	15.28	13	149947	28500	90449987
Croup infectious	17.42	15.28	12	149948	675	90477812
Pneumocystis jirovecii pneumonia	17.35	15.28	7	149953	21609	90456878
Congenital hypogonadotropic hypogonadism	17.35	15.28	5	149955	30	90478457
Hypopituitarism foetal	17.35	15.28	5	149955	30	90478457
Ejection fraction decreased	17.34	15.28	11	149949	26242	90452245
Sinus polyp	17.29	15.28	10	149950	413	90478074
Steroid diabetes	17.24	15.28	21	149939	2481	90476006
Nasal turbinate abnormality	17.21	15.28	5	149955	31	90478456
Dementia	17.18	15.28	9	149951	23852	90454635
Upper respiratory tract infection	17.10	15.28	303	149657	128015	90350472
Metastases to central nervous system	17.10	15.28	4	149956	17538	90460949
Surgery	17.08	15.28	30	149930	44857	90433630
Basal cell carcinoma	17.07	15.28	18	149942	33371	90445116
Carcinoid syndrome	17.02	15.28	8	149952	214	90478273
Withdrawal syndrome	16.96	15.28	8	149952	22516	90455971
Metastases to lung	16.93	15.28	3	149957	15988	90462499
Exposure to fungus	16.88	15.28	8	149952	218	90478269
Nonspecific reaction	16.85	15.28	22	149938	2787	90475700
Therapeutic product effect incomplete	16.75	15.28	223	149737	193673	90284814
Blood creatine phosphokinase increased	16.66	15.28	19	149941	34004	90444483
Malnutrition	16.63	15.28	5	149955	18553	90459934
Intentional product misuse	16.55	15.28	84	149876	89520	90388967
Pericardial effusion	16.54	15.28	22	149938	36811	90441676
Ulcer	16.50	15.28	18	149942	32864	90445623
Animal bite	16.40	15.28	23	149937	3120	90475367
Blood sodium decreased	16.35	15.28	13	149947	27600	90450887
Cold agglutinins positive	16.33	15.28	5	149955	38	90478449
Disorientation	16.33	15.28	30	149930	44084	90434403
Vascular endothelial growth factor assay	16.22	15.28	3	149957	0	90478487
Vital capacity abnormal	16.22	15.28	3	149957	0	90478487
Breast mass	16.15	15.28	43	149917	9404	90469083
Product prescribing error	16.09	15.28	95	149865	30050	90448437
Myositis	16.08	15.28	10	149950	24118	90454369
Blood test abnormal	16.03	15.28	73	149887	20879	90457608
Liver function test increased	15.99	15.28	79	149881	84776	90393711
Musculoskeletal disorder	15.99	15.28	8	149952	21761	90456726
Exposure to SARS-CoV-2	15.96	15.28	20	149940	2432	90476055
Tongue discolouration	15.95	15.28	24	149936	3469	90475018
Lung disorder	15.94	15.28	342	149618	149541	90328946
Osteoporosis	15.91	15.28	94	149866	96437	90382050
Oropharyngeal oedema	15.85	15.28	9	149951	359	90478128
Emphysema	15.65	15.28	50	149910	12105	90466382
Overweight	15.63	15.28	32	149928	5902	90472585
Abnormal behaviour	15.61	15.28	9	149951	22619	90455868
Acute myocardial infarction	15.50	15.28	21	149939	34869	90443618
Injection site eczema	15.48	15.28	6	149954	98	90478389
Coordination abnormal	15.46	15.28	8	149952	21348	90457139
Schizophrenia	15.36	15.28	3	149957	14911	90463576
Pleuritic pain	15.31	15.28	45	149915	10416	90468071
Pharyngeal hypoaesthesia	15.30	15.28	9	149951	384	90478103

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
No adverse event	3297.65	18.55	1345	47411	37676	42534903
Urticaria	1077.41	18.55	796	47960	73240	42499339
Wheezing	957.90	18.55	659	48097	54122	42518457
Forced expiratory volume decreased	799.22	18.55	308	48448	7322	42565257
Nasopharyngitis	513.05	18.55	553	48203	83443	42489136
Cough	498.88	18.55	798	47958	177305	42395274
Blood immunoglobulin E increased	473.17	18.55	172	48584	3453	42569126
Sputum discoloured	469.30	18.55	230	48526	9902	42562677
Anaphylactic reaction	404.60	18.55	358	48398	42385	42530194
Obstructive airways disorder	397.39	18.55	283	48473	24476	42548103
Nasal congestion	394.33	18.55	302	48454	29199	42543380
Dyspnoea	392.65	18.55	1251	47505	441370	42131209
Productive cough	386.05	18.55	379	48377	51188	42521391
Middle insomnia	375.30	18.55	182	48574	7651	42564928
Chest discomfort	365.84	18.55	406	48350	63210	42509369
Blood pressure systolic increased	364.37	18.55	282	48474	27686	42544893
Blood pressure increased	354.87	18.55	506	48250	101422	42471157
Asthma	346.84	18.55	391	48365	61923	42510656
Acute kidney injury	337.93	18.55	21	48735	367316	42205263
Off label use	319.93	18.55	1505	47251	636830	41935749
Body temperature decreased	308.50	18.55	197	48559	14216	42558363
Hypersensitivity	258.64	18.55	364	48392	72006	42500573
Respiratory tract congestion	253.83	18.55	139	48617	7539	42565040
Drug interaction	252.27	18.55	13	48743	266986	42305593
Influenza	249.80	18.55	331	48425	61844	42510735
Heart rate increased	236.58	18.55	298	48458	52957	42519622
Sensitivity to weather change	215.71	18.55	83	48673	1960	42570619
Nasal polyps	213.62	18.55	99	48657	3752	42568827
Pruritus	209.37	18.55	579	48177	188192	42384387
Hypoventilation	205.49	18.55	96	48660	3706	42568873
Respiratory rate increased	199.77	18.55	136	48620	10926	42561653
Anaemia	188.04	18.55	45	48711	280233	42292346
Neutropenia	187.35	18.55	10	48746	199421	42373158
Malaise	176.26	18.55	588	48168	211568	42361011
Rhinorrhoea	172.46	18.55	197	48559	31597	42540982
Thrombocytopenia	157.74	18.55	17	48739	190262	42382317
Angioedema	155.12	18.55	216	48540	42261	42530318
Sinusitis	148.66	18.55	224	48532	47068	42525511
Bronchitis	146.15	18.55	222	48534	46979	42525600
Diarrhoea	143.43	18.55	191	48565	460658	42111921
Seasonal allergy	131.29	18.55	93	48663	7962	42564617
Disease progression	129.44	18.55	9	48747	143647	42428932
Lower respiratory tract infection	127.83	18.55	194	48562	41012	42531567
Asthmatic crisis	127.38	18.55	40	48716	501	42572078
Sinus congestion	126.45	18.55	86	48670	6894	42565685
Oropharyngeal pain	126.06	18.55	196	48560	42314	42530265
Bronchopulmonary aspergillosis allergic	124.32	18.55	73	48683	4525	42568054
Weight decreased	123.80	18.55	518	48238	207430	42365149
Weight increased	122.21	18.55	334	48422	107649	42464930
Pulmonary function test decreased	116.82	18.55	76	48680	5656	42566923
Pancytopenia	116.80	18.55	4	48752	117739	42454840
Eosinophilic granulomatosis with polyangiitis	116.57	18.55	89	48667	8549	42564030
Respiratory disorder	114.96	18.55	134	48622	21951	42550628
Dyspnoea exertional	112.40	18.55	204	48552	49944	42522635
Malignant neoplasm progression	109.99	18.55	3	48753	108397	42464182
Smoke sensitivity	109.99	18.55	29	48727	183	42572396
Forced vital capacity decreased	109.37	18.55	41	48715	899	42571680
Perfume sensitivity	107.04	18.55	27	48729	139	42572440
Hypotension	104.48	18.55	85	48671	257546	42315033
Renal failure	100.41	18.55	21	48735	143705	42428874
Allergy to animal	98.32	18.55	33	48723	517	42572062
Constipation	95.89	18.55	33	48723	162258	42410321
Platelet count decreased	93.27	18.55	22	48734	138559	42434020
Completed suicide	93.20	18.55	4	48752	96461	42476118
Confusional state	89.27	18.55	40	48716	167557	42405022
Rhinitis allergic	88.40	18.55	55	48701	3787	42568792
Overdose	83.22	18.55	11	48745	105253	42467326
Lower respiratory tract congestion	82.15	18.55	39	48717	1561	42571018
Dehydration	81.73	18.55	30	48726	141737	42430842
Food allergy	81.20	18.55	43	48713	2178	42570401
White blood cell count decreased	79.46	18.55	15	48741	110381	42462198
Temperature intolerance	77.37	18.55	55	48701	4733	42567846
Stress	76.13	18.55	161	48595	44051	42528528
Headache	76.02	18.55	501	48255	238868	42333711
Sneezing	75.99	18.55	61	48695	6302	42566277
Hyponatraemia	74.72	18.55	13	48743	101449	42471130
Chronic obstructive pulmonary disease	74.11	18.55	198	48558	62916	42509663
Septic shock	73.86	18.55	9	48747	91663	42480916
Peak expiratory flow rate decreased	72.46	18.55	19	48737	117	42572462
Bronchospasm	71.80	18.55	81	48675	12804	42559775
Sepsis	70.99	18.55	74	48682	199260	42373319
Throat tightness	70.68	18.55	70	48686	9529	42563050
Nasal discharge discolouration	69.10	18.55	24	48732	419	42572160
Increased viscosity of bronchial secretion	69.02	18.55	21	48735	235	42572344
Haemoglobin decreased	68.38	18.55	33	48723	132438	42440141
Coagulation factor deficiency	67.39	18.55	21	48735	256	42572323
Erythema	66.93	18.55	274	48482	108519	42464060
Rhonchi	66.22	18.55	37	48719	2086	42570493
Humidity intolerance	66.07	18.55	13	48743	13	42572566
Breath sounds abnormal	65.65	18.55	75	48681	12018	42560561
Increased bronchial secretion	65.41	18.55	38	48718	2308	42570271
Cardiac arrest	64.93	18.55	22	48734	109298	42463281
Sputum increased	64.60	18.55	42	48714	3121	42569458
Throat irritation	64.36	18.55	77	48679	12959	42559620
Discomfort	63.48	18.55	108	48648	25111	42547468
Restrictive pulmonary disease	63.25	18.55	31	48725	1332	42571247
Rhabdomyolysis	62.02	18.55	8	48748	78011	42494568
Factor V Leiden mutation	61.94	18.55	19	48737	219	42572360
Gastrointestinal haemorrhage	61.01	18.55	18	48738	97708	42474871
Eosinophil count increased	60.55	18.55	68	48688	10695	42561884
Coagulation factor V level abnormal	60.32	18.55	17	48739	142	42572437
Renal impairment	59.14	18.55	26	48730	110202	42462377
Eye swelling	58.18	18.55	70	48686	11850	42560729
Neutrophil count decreased	57.00	18.55	4	48752	63411	42509168
Aspartate aminotransferase increased	56.55	18.55	10	48746	77153	42495426
Influenza like illness	56.03	18.55	117	48639	31723	42540856
Interstitial lung disease	55.73	18.55	11	48745	78451	42494128
Illness	55.29	18.55	101	48655	24829	42547750
Injection site pain	54.89	18.55	168	48588	57630	42514949
Blood creatinine increased	54.37	18.55	29	48727	109974	42462605
Swelling face	54.14	18.55	106	48650	27448	42545131
Forced expiratory flow decreased	53.68	18.55	16	48740	166	42572413
Multiple organ dysfunction syndrome	53.48	18.55	22	48734	97013	42475566
Lip swelling	52.52	18.55	85	48671	18968	42553611
Alanine aminotransferase increased	52.13	18.55	18	48738	88388	42484191
Vital capacity decreased	51.02	18.55	20	48736	497	42572082
Rales	50.88	18.55	64	48692	11336	42561243
Chronic sinusitis	50.33	18.55	37	48719	3355	42569224
Neuropathy peripheral	50.12	18.55	27	48729	101826	42470753
Ascites	49.73	18.55	4	48752	56674	42515905
Delirium	48.12	18.55	3	48753	52516	42520063
Decreased appetite	47.63	18.55	93	48663	193044	42379535
Infusion related reaction	46.52	18.55	7	48749	60799	42511780
Nausea	46.13	18.55	266	48490	396533	42176046
Bradycardia	46.11	18.55	20	48736	85464	42487115
Hypoglycaemia	45.55	18.55	7	48749	59847	42512732
Maternal exposure timing unspecified	45.34	18.55	17	48739	373	42572206
Acne	44.80	18.55	66	48690	13578	42559001
Mucosal inflammation	44.70	18.55	3	48753	49371	42523208
FEV1/FVC ratio decreased	43.96	18.55	13	48743	131	42572448
Ear infection	43.58	18.55	63	48693	12741	42559838
Respiratory tract infection	43.16	18.55	94	48662	26228	42546351
Asthma-chronic obstructive pulmonary disease overlap syndrome	42.80	18.55	25	48731	1534	42571045
Plasma cell myeloma	42.76	18.55	3	48753	47575	42525004
Eczema	42.09	18.55	109	48647	33977	42538602
Skin plaque	41.77	18.55	42	48714	5821	42566758
Dermoid cyst	41.10	18.55	13	48743	167	42572412
Throat clearing	41.01	18.55	18	48738	599	42571980
Dysphonia	40.43	18.55	96	48660	28354	42544225
Mast cell activation syndrome	40.26	18.55	15	48741	323	42572256
Cardio-respiratory arrest	40.03	18.55	9	48747	58627	42513952
Death	40.01	18.55	346	48410	470839	42101740
Chronic kidney disease	39.65	18.55	4	48752	47237	42525342
Blood immunoglobulin E decreased	39.40	18.55	10	48746	53	42572526
Seizure	39.34	18.55	48	48708	120513	42452066
Coma	39.11	18.55	7	48749	53547	42519032
Endocarditis fibroplastica	38.88	18.55	8	48748	12	42572567
Pleural effusion	38.14	18.55	33	48723	97133	42475446
Sinus disorder	37.21	18.55	46	48710	8004	42564575
Blood bilirubin increased	37.02	18.55	3	48753	42249	42530330
Serum sickness	36.97	18.55	26	48730	2199	42570380
Arthralgia	36.54	18.55	377	48379	204861	42367718
Concomitant disease aggravated	36.01	18.55	41	48715	6545	42566034
Hypereosinophilic syndrome	35.91	18.55	15	48741	441	42572138
Secretion discharge	35.89	18.55	44	48712	7591	42564988
Upper respiratory tract congestion	35.68	18.55	19	48737	973	42571606
Rhinitis	35.16	18.55	55	48701	11922	42560657
Respiratory failure	34.88	18.55	58	48698	128074	42444505
Multiple allergies	34.77	18.55	31	48725	3697	42568882
Drug intolerance	34.47	18.55	25	48731	80399	42492180
Urticaria chronic	34.38	18.55	11	48745	147	42572432
Diaphragmatic disorder	34.36	18.55	20	48736	1219	42571360
Upper-airway cough syndrome	34.31	18.55	33	48723	4333	42568246
Dust allergy	34.02	18.55	36	48720	5296	42567283
International normalised ratio increased	33.68	18.55	7	48749	48161	42524418
Gastroenteritis viral	33.40	18.55	44	48712	8155	42564424
Injection site urticaria	33.28	18.55	29	48727	3354	42569225
Claustrophobia	33.27	18.55	13	48743	320	42572259
Anosmia	33.12	18.55	35	48721	5141	42567438
Drug-induced liver injury	32.76	18.55	3	48753	38270	42534309
Blood immunoglobulin E abnormal	32.75	18.55	7	48749	14	42572565
Drug ineffective	32.50	18.55	946	47810	629251	41943328
Dermatitis atopic	32.38	18.55	54	48702	12350	42560229
Viral infection	32.09	18.55	76	48680	22407	42550172
Body mass index increased	32.00	18.55	19	48737	1202	42571377
Stomatitis	31.90	18.55	9	48747	50320	42522259
Injection related reaction	31.58	18.55	15	48741	601	42571978
Eye pruritus	31.57	18.55	51	48705	11361	42561218
Upper respiratory tract infection	31.46	18.55	113	48643	42060	42530519
Bronchial irritation	31.12	18.55	8	48748	45	42572534
Vomiting	31.10	18.55	199	48557	289524	42283055
Polyp	30.96	18.55	32	48724	4582	42567997
Blood pressure diastolic decreased	30.95	18.55	48	48708	10327	42562252
Joint warmth	30.88	18.55	15	48741	632	42571947
Lung hyperinflation	30.69	18.55	18	48738	1113	42571466
Feeling abnormal	30.45	18.55	159	48597	69627	42502952
Haematuria	30.41	18.55	14	48742	57785	42514794
Maternal exposure during breast feeding	30.18	18.55	20	48736	1535	42571044
Oropharyngeal discomfort	30.07	18.55	30	48726	4119	42568460
Status asthmaticus	30.03	18.55	12	48744	314	42572265
Nasal discomfort	29.86	18.55	20	48736	1562	42571017
Mental status changes	29.70	18.55	6	48750	42109	42530470
Hepatic function abnormal	29.54	18.55	11	48745	51556	42521023
Dyspnoea at rest	29.47	18.55	30	48726	4219	42568360
Haematochezia	29.46	18.55	15	48741	58421	42514158
Cardiac failure	29.43	18.55	48	48708	106808	42465771
Injection site swelling	29.42	18.55	62	48694	16911	42555668
Pneumonitis	29.30	18.55	6	48750	41712	42530867
Scratch	29.18	18.55	33	48723	5228	42567351
Lacrimation increased	29.12	18.55	50	48706	11708	42560871
Pulmonary congestion	29.07	18.55	59	48697	15671	42556908
Urticaria thermal	28.87	18.55	5	48751	0	42572579
Hyposmia	28.56	18.55	12	48744	358	42572221
Allergy to chemicals	28.35	18.55	9	48747	117	42572462
Therapeutic response decreased	28.32	18.55	100	48656	36912	42535667
Anaphylactoid reaction	28.20	18.55	25	48731	2958	42569621
Decreased activity	28.13	18.55	32	48724	5103	42567476
Atrial fibrillation	28.08	18.55	75	48681	139518	42433061
Nasal disorder	27.76	18.55	21	48735	1988	42570591
Hyperglycaemia	27.61	18.55	9	48747	45850	42526729
Lower respiratory tract infection viral	27.53	18.55	13	48743	514	42572065
Rubber sensitivity	27.43	18.55	12	48744	396	42572183
Treatment noncompliance	27.34	18.55	5	48751	37667	42534912
Sputum retention	27.07	18.55	14	48742	675	42571904
Injection site hypersensitivity	26.99	18.55	12	48744	412	42572167
Needle issue	26.91	18.55	41	48715	8686	42563893
Measles	26.83	18.55	11	48745	308	42572271
Respiratory tract irritation	26.63	18.55	11	48745	314	42572265
Increased upper airway secretion	25.33	18.55	22	48734	2534	42570045
Quality of life decreased	25.30	18.55	31	48725	5345	42567234
Cardiogenic shock	25.29	18.55	5	48751	35635	42536944
Urinary tract infection	25.15	18.55	47	48709	99237	42473342
Rib fracture	24.72	18.55	57	48699	16514	42556065
Inappropriate schedule of product administration	24.68	18.55	191	48565	95711	42476868
Cholestasis	24.66	18.55	4	48752	32875	42539704
Cerebral haemorrhage	24.63	18.55	7	48749	38959	42533620
Expiratory reserve volume decreased	24.60	18.55	8	48748	113	42572466
Nasal pruritus	24.50	18.55	9	48747	186	42572393
Upper gastrointestinal haemorrhage	24.33	18.55	3	48753	30296	42542283
Bronchiolitis	24.26	18.55	26	48730	3880	42568699
Haematemesis	24.23	18.55	3	48753	30196	42542383
Therapeutic product effect incomplete	23.97	18.55	151	48605	70788	42501791
Lung diffusion test decreased	23.88	18.55	14	48742	865	42571714
Cognitive disorder	23.82	18.55	5	48751	34167	42538412
Lung disorder	23.59	18.55	113	48643	47810	42524769
Papule	23.32	18.55	31	48725	5795	42566784
Product storage error	23.28	18.55	44	48712	11096	42561483
Rectal haemorrhage	23.17	18.55	14	48742	49592	42522987
Unresponsive to stimuli	23.15	18.55	4	48752	31399	42541180
Full blood count abnormal	23.10	18.55	81	48675	29795	42542784
Lymphostasis	23.07	18.55	5	48751	11	42572568
Suicide attempt	22.99	18.55	12	48744	46088	42526491
Skin reaction	22.93	18.55	34	48722	7033	42565546
Rosacea	22.76	18.55	16	48740	1352	42571227
Condition aggravated	22.71	18.55	190	48566	260564	42312015
Hepatic enzyme increased	22.71	18.55	12	48744	45772	42526807
Incorrect dose administered	22.62	18.55	120	48636	52854	42519725
Urinary retention	22.56	18.55	10	48746	42204	42530375
Swelling	22.54	18.55	123	48633	54762	42517817
Migraine	22.39	18.55	72	48684	25342	42547237
Dysarthria	21.96	18.55	9	48747	39798	42532781
Colitis	21.96	18.55	13	48743	46559	42526020
Ligament sprain	21.93	18.55	26	48730	4332	42568247
Depressed level of consciousness	21.77	18.55	14	48742	47956	42524623
Crepitations	21.76	18.55	23	48733	3378	42569201
Dermatitis contact	21.25	18.55	26	48730	4477	42568102
Blood test abnormal	21.05	18.55	46	48710	12860	42559719
Injection site bruising	21.03	18.55	43	48713	11482	42561097
Cystic fibrosis	21.00	18.55	18	48738	2037	42570542
Carboxyhaemoglobin increased	20.99	18.55	6	48750	53	42572526
Altered state of consciousness	20.98	18.55	4	48752	29255	42543324
Insomnia	20.90	18.55	217	48539	118036	42454543
Clavicle fracture	20.56	18.55	20	48736	2663	42569916
Central obesity	20.53	18.55	12	48744	737	42571842
Infective pulmonary exacerbation of cystic fibrosis	20.36	18.55	34	48722	7784	42564795
Abnormal behaviour	20.33	18.55	3	48753	26448	42546131
Coronary artery disease	20.17	18.55	19	48737	53701	42518878
Liver function test abnormal	20.14	18.55	6	48750	32385	42540194
Choking	20.01	18.55	30	48726	6268	42566311
Pharyngeal swelling	19.98	18.55	22	48734	3385	42569194
Paranasal sinus discomfort	19.92	18.55	14	48742	1183	42571396
Rash maculo-papular	19.86	18.55	9	48747	37494	42535085
Animal scratch	19.68	18.55	8	48748	219	42572360
Hypohidrosis	19.48	18.55	8	48748	225	42572354
Total lung capacity decreased	19.14	18.55	22	48734	3548	42569031
Pancreatitis	19.13	18.55	13	48743	43255	42529324
Procedural pain	19.03	18.55	28	48728	5751	42566828
Hepatotoxicity	19.01	18.55	3	48753	25164	42547415
Psychotic disorder	18.92	18.55	5	48751	29203	42543376
Somnolence	18.89	18.55	90	48666	141015	42431564
Congenital anomaly	18.88	18.55	15	48741	1526	42571053
Disorientation	18.85	18.55	9	48747	36380	42536199
Cardiac failure congestive	18.75	18.55	44	48712	85558	42487021

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
No adverse event	6936.56	16.03	2988	166173	70851	110349287
Urticaria	2994.87	16.03	3021	166140	315836	110104302
Wheezing	2755.75	16.03	2611	166550	252619	110167519
Forced expiratory volume decreased	2648.47	16.03	928	168233	12248	110407890
Cough	2218.16	16.03	3106	166055	458535	109961603
Sputum discoloured	1742.14	16.03	852	168309	27093	110393045
Obstructive airways disorder	1587.26	16.03	948	168213	45201	110374937
Dyspnoea	1495.00	16.03	4377	164784	1102495	109317643
Productive cough	1300.98	16.03	1206	167955	113099	110307039
Anaphylactic reaction	1297.16	16.03	1204	167957	113096	110307042
Middle insomnia	1203.15	16.03	600	168561	19902	110400236
Asthma	1123.20	16.03	1633	167528	248658	110171480
Nasal congestion	1015.21	16.03	983	168178	97299	110322839
Chest discomfort	954.96	16.03	1251	167910	172597	110247541
Blood immunoglobulin E increased	862.35	16.03	351	168810	7131	110413007
Blood pressure systolic increased	856.87	16.03	830	168331	82161	110337977
Acute kidney injury	847.30	16.03	28	169133	635402	109784736
Sensitivity to weather change	801.23	16.03	363	168798	9665	110410473
Heart rate increased	792.76	16.03	1037	168124	142797	110277341
Influenza	770.55	16.03	1112	168049	167989	110252149
Blood pressure increased	732.38	16.03	1371	167790	257002	110163136
Respiratory tract infection	681.17	16.03	685	168476	70932	110349206
Toxicity to various agents	675.24	16.03	12	169149	480543	109939595
Oropharyngeal pain	671.60	16.03	927	168234	134349	110285789
Pruritus	667.65	16.03	2179	166982	579381	109840757
Malaise	667.24	16.03	2398	166763	669421	109750717
Nasopharyngitis	660.87	16.03	1693	167468	392668	110027470
Nasal polyps	595.73	16.03	324	168837	12876	110407262
Drug interaction	591.31	16.03	46	169115	500137	109920001
Nasal oedema	579.61	16.03	258	168903	6581	110413557
Angioedema	556.26	16.03	719	168442	97781	110322357
Hypoventilation	547.59	16.03	261	168900	7820	110412318
Neutropenia	527.59	16.03	9	169152	374611	110045527
Rhinorrhoea	520.68	16.03	711	168450	101955	110318183
Pneumonia	517.75	16.03	2674	166487	874040	109546098
Body temperature decreased	513.92	16.03	437	168724	36498	110383640
Respiratory tract congestion	502.40	16.03	400	168761	30457	110389681
Infusion related reaction	496.53	16.03	20	169141	381142	110038996
Skin plaque	477.18	16.03	276	168885	12369	110407769
Seasonal allergy	468.48	16.03	321	168840	19401	110400737
Asthmatic crisis	461.61	16.03	159	169002	1983	110418155
Upper-airway cough syndrome	461.49	16.03	293	168868	15564	110404574
Bronchitis	447.87	16.03	836	168325	156196	110263942
Respiratory rate increased	438.24	16.03	339	168822	24744	110395394
Illness	410.46	16.03	565	168596	81606	110338532
Perfume sensitivity	394.76	16.03	120	169041	971	110419167
Thrombocytopenia	380.57	16.03	44	169117	348841	110071297
Drug hypersensitivity	377.29	16.03	1533	167628	452557	109967581
Synovitis	376.19	16.03	9	169152	274083	110146055
Weight decreased	374.61	16.03	1562	167599	466495	109953643
Rales	371.65	16.03	306	168855	24433	110395705
Breath sounds abnormal	368.68	16.03	308	168853	25096	110395042
Oedema	368.30	16.03	918	168243	209058	110211080
Off label use	363.37	16.03	3690	165471	1496495	108923643
Confusional state	360.87	16.03	133	169028	468547	109951591
Anaemia	357.56	16.03	196	168965	546890	109873248
Stress	357.10	16.03	605	168556	104743	110315395
Bronchopulmonary aspergillosis allergic	355.91	16.03	198	168963	8228	110411910
Contraindicated product administered	345.21	16.03	7	169154	248260	110171878
Forced vital capacity decreased	332.57	16.03	122	169039	1848	110418290
Pulmonary function test abnormal	331.19	16.03	159	169002	4841	110415297
Throat tightness	326.91	16.03	325	168836	33164	110386974
Rhinitis allergic	323.55	16.03	247	168914	17675	110402463
Secretion discharge	320.10	16.03	258	168903	19986	110400152
Diarrhoea	307.99	16.03	819	168342	1138686	109281452
Sneezing	307.79	16.03	308	168853	31676	110388462
Pulmonary function test decreased	307.44	16.03	182	168979	8518	110411620
Pemphigus	306.90	16.03	4	169157	214566	110205572
Full blood count abnormal	306.73	16.03	403	168758	55649	110364489
Pancytopenia	303.91	16.03	3	169158	209610	110210528
Stomatitis	297.38	16.03	33	169128	270209	110149929
Hand deformity	293.02	16.03	9	169152	218497	110201641
Hepatic enzyme increased	292.95	16.03	66	169095	320826	110099312
Drug intolerance	278.28	16.03	137	169024	406375	110013763
Allergy to animal	273.72	16.03	105	169056	1811	110418327
Hyponatraemia	271.73	16.03	15	169146	217638	110202500
Hypotension	262.18	16.03	249	168912	523600	109896538
Inappropriate schedule of product administration	262.08	16.03	795	168366	202842	110217296
Dyspnoea exertional	261.11	16.03	525	168636	103535	110316603
Systemic lupus erythematosus	256.15	16.03	41	169120	254297	110165841
Duodenal ulcer perforation	255.51	16.03	3	169158	177697	110242441
Platelet count decreased	251.37	16.03	29	169132	230414	110189724
Disease progression	248.80	16.03	38	169123	243996	110176142
Erythema	243.33	16.03	986	168175	290461	110129677
Smoke sensitivity	243.00	16.03	75	169086	642	110419496
Anti-cyclic citrullinated peptide antibody positive	242.19	16.03	8	169153	181976	110238162
Psoriatic arthropathy	238.26	16.03	16	169145	196745	110223393
Peak expiratory flow rate decreased	236.30	16.03	73	169088	627	110419511
Helicobacter infection	235.16	16.03	10	169151	181867	110238271
Glossodynia	234.66	16.03	31	169130	221973	110198165
Hypersensitivity	232.97	16.03	1226	167935	402772	110017366
Arthropathy	230.77	16.03	76	169085	287446	110132692
Scratch	227.98	16.03	176	168985	12803	110407335
Incorrect dose administered	226.33	16.03	494	168667	103147	110316991
Drug abuse	225.31	16.03	11	169150	177400	110242738
Pericarditis	223.63	16.03	34	169127	219080	110201058
White blood cell count decreased	222.15	16.03	41	169120	229349	110190789
Hypokalaemia	220.43	16.03	15	169146	182433	110237705
Sinus congestion	220.10	16.03	252	168909	30207	110389931
Condition aggravated	215.31	16.03	506	168655	734330	109685808
Liver injury	214.21	16.03	3	169158	150410	110269728
Eye pruritus	213.30	16.03	257	168904	32518	110387620
Death	213.03	16.03	471	168690	698398	109721740
Humidity intolerance	211.28	16.03	62	169099	438	110419700
Dehydration	210.49	16.03	82	169079	279429	110140709
Feeling abnormal	208.12	16.03	679	168482	180032	110240106
Vital capacity decreased	201.02	16.03	86	169075	1987	110418151
Joint swelling	199.55	16.03	230	168931	442615	109977523
Folliculitis	199.04	16.03	15	169146	167638	110252500
Bronchospasm	198.23	16.03	238	168923	30001	110390137
Lower respiratory tract congestion	197.92	16.03	111	169050	4685	110415453
Nasal discharge discolouration	197.59	16.03	97	169064	3104	110417034
Ear pruritus	196.06	16.03	128	169033	7132	110413006
Temperature intolerance	195.95	16.03	166	168995	13784	110406354
Muscle injury	195.57	16.03	4	169157	140803	110279335
Rheumatoid arthritis	194.56	16.03	108	169053	299505	110120633
Lacrimation increased	193.79	16.03	238	168923	30712	110389426
Dysphonia	187.97	16.03	381	168780	75548	110344590
Septic shock	187.27	16.03	14	169147	157514	110262624
Impaired healing	186.56	16.03	37	169124	196680	110223458
Rheumatoid factor positive	185.86	16.03	3	169158	131637	110288501
Bronchiectasis	185.28	16.03	253	168908	36240	110383898
Swelling face	184.72	16.03	425	168736	91896	110328242
Overdose	183.76	16.03	64	169097	233730	110186408
Intentional overdose	183.09	16.03	4	169157	132497	110287641
C-reactive protein abnormal	182.92	16.03	3	169158	129692	110290446
Sinus pain	182.03	16.03	113	169048	5766	110414372
Constipation	181.30	16.03	168	168993	357618	110062520
Hyperkalaemia	180.57	16.03	6	169155	135790	110284348
Throat irritation	179.34	16.03	306	168855	53246	110366892
Bronchial secretion retention	177.26	16.03	105	169056	4919	110415219
Aphonia	172.42	16.03	149	169012	12711	110407427
Leukopenia	171.94	16.03	15	169146	148776	110271362
Viral infection	170.57	16.03	298	168863	52841	110367297
Influenza like illness	168.13	16.03	399	168762	88013	110332125
Alanine aminotransferase increased	167.24	16.03	38	169123	183735	110236403
Animal scratch	166.77	16.03	73	169088	1786	110418352
Sepsis	166.68	16.03	153	169008	327193	110092945
Eye swelling	166.09	16.03	228	168933	32820	110387318
Eosinophilic granulomatosis with polyangiitis	164.31	16.03	134	169027	10552	110409586
Injection site pain	163.82	16.03	621	168540	177301	110242837
Renal failure	163.24	16.03	71	169090	226503	110193635
Respiratory disorder	160.12	16.03	344	168817	71038	110349100
Lip swelling	159.86	16.03	282	168879	50385	110369753
Gastrointestinal haemorrhage	159.34	16.03	30	169131	165488	110254650
Rhabdomyolysis	157.72	16.03	6	169155	120395	110299743
Irritable bowel syndrome	157.58	16.03	30	169131	164185	110255953
Decreased appetite	157.24	16.03	306	168855	475540	109944598
Eosinophil count increased	156.85	16.03	177	168984	20881	110399257
Pharyngeal swelling	156.46	16.03	137	169024	11895	110408243
Reversible airways obstruction	155.06	16.03	76	169085	2423	110417715
Sinusitis	154.46	16.03	876	168285	295812	110124326
Aspartate aminotransferase increased	153.94	16.03	29	169132	159907	110260231
Exposure to allergen	153.77	16.03	50	169111	515	110419623
Total lung capacity decreased	153.07	16.03	109	169052	7005	110413133
Nausea	152.87	16.03	1186	167975	1234504	109185634
Urticaria thermal	152.71	16.03	49	169112	482	110419656
Delirium	152.31	16.03	15	169146	135010	110285128
Paranasal sinus discomfort	151.50	16.03	104	169057	6301	110413837
Multiple organ dysfunction syndrome	151.48	16.03	25	169136	151685	110268453
Food allergy	149.15	16.03	168	168993	19780	110400358
Drug-induced liver injury	144.64	16.03	10	169151	120057	110300081
Headache	143.90	16.03	2016	167145	880361	109539777
Neutrophil count decreased	143.04	16.03	11	169150	120930	110299208
Sleep disorder due to general medical condition, insomnia type	142.87	16.03	4	169157	105639	110314499
Abdominal discomfort	141.04	16.03	241	168920	393617	110026521
Dust allergy	140.91	16.03	97	169064	5904	110414234
Product use issue	140.20	16.03	162	168999	311533	110108605
Rubber sensitivity	139.55	16.03	70	169091	2348	110417790
Urinary tract discomfort	137.48	16.03	53	169108	927	110419211
Cardiac arrest	136.51	16.03	65	169096	196688	110223450
Restrictive pulmonary disease	136.05	16.03	76	169085	3183	110416955
Chest X-ray abnormal	135.94	16.03	109	169052	8378	110411760
C-reactive protein increased	135.13	16.03	83	169078	217836	110202302
Treatment failure	133.65	16.03	136	169025	277098	110143040
Facet joint syndrome	133.48	16.03	3	169158	96825	110323313
Joint range of motion decreased	131.16	16.03	16	169145	121816	110298322
Throat clearing	130.91	16.03	82	169079	4251	110415887
Respiratory failure	130.78	16.03	84	169077	215248	110204890
Bradycardia	130.30	16.03	38	169123	155479	110264659
Renal impairment	129.60	16.03	63	169098	188382	110231756
Mucosal inflammation	128.70	16.03	4	169157	96137	110324001
Electrocardiogram QT prolonged	128.61	16.03	10	169151	108950	110311188
Mechanical urticaria	128.44	16.03	44	169117	539	110419599
Interstitial lung disease	126.39	16.03	29	169132	139305	110280833
Increased bronchial secretion	125.06	16.03	77	169084	3871	110416267
Neuropathy peripheral	124.72	16.03	59	169102	179218	110240920
Frustration tolerance decreased	122.84	16.03	104	169057	8627	110411511
Atrial fibrillation	122.09	16.03	103	169058	229539	110190599
Alveolar osteitis	121.94	16.03	50	169111	1035	110419103
Multiple allergies	121.49	16.03	120	169041	12143	110407995
Lower respiratory tract infection	120.74	16.03	709	168452	242397	110177741
Forced expiratory flow decreased	116.03	16.03	35	169126	275	110419863
Adverse event	115.41	16.03	15	169146	108794	110311344
Therapeutic product effect decreased	115.33	16.03	122	169039	244194	110175944
Wound	115.29	16.03	113	169048	234324	110185814
Product availability issue	115.17	16.03	96	169065	7794	110412344
Ear congestion	114.88	16.03	71	169090	3594	110416544
Ascites	113.95	16.03	7	169154	92801	110327337
Liver disorder	113.37	16.03	38	169123	142205	110277933
Lip dry	113.19	16.03	11	169150	100072	110320066
Myalgia	112.66	16.03	652	168509	221729	110198409
Encephalopathy	109.86	16.03	3	169158	81052	110339086
General physical health deterioration	108.89	16.03	313	168848	424982	109995156
Cardio-respiratory arrest	107.30	16.03	23	169138	115813	110304325
Weight increased	106.16	16.03	1044	168117	418600	110001538
Lactic acidosis	105.49	16.03	10	169151	92801	110327337
International normalised ratio increased	105.18	16.03	7	169154	86765	110333373
Rhinitis	103.57	16.03	149	169012	22396	110397742
Depressed level of consciousness	102.57	16.03	23	169138	112255	110307883
Cardiac failure congestive	101.53	16.03	52	169109	150948	110269190
Prescribed overdose	100.71	16.03	9	169152	87572	110332566
Coma	100.22	16.03	28	169133	117841	110302297
FEV1/FVC ratio decreased	99.86	16.03	31	169130	271	110419867
Chronic obstructive pulmonary disease	99.60	16.03	380	168781	108778	110311360
Papule	98.25	16.03	98	169063	10035	110410103
Injection site scab	98.04	16.03	37	169124	609	110419529
Tunnel vision	98.02	16.03	52	169109	1963	110418175
Intentional product use issue	96.91	16.03	143	169018	247763	110172375
Pulmonary mass	96.88	16.03	191	168970	37110	110383028
Peripheral venous disease	95.77	16.03	9	169152	84108	110336030
Increased viscosity of bronchial secretion	95.53	16.03	36	169125	590	110419548
Suicide attempt	92.81	16.03	22	169139	103372	110316766
Eczema	91.73	16.03	281	168880	72012	110348126
Chest pain	91.61	16.03	929	168232	375446	110044692
Blood immunoglobulin E decreased	90.66	16.03	27	169134	202	110419936
Rectal haemorrhage	90.41	16.03	35	169126	119798	110300340
Oropharyngeal discomfort	89.46	16.03	94	169067	10233	110409905
Sputum culture positive	89.28	16.03	62	169099	3827	110416311
Mastocytosis	88.96	16.03	37	169124	795	110419343
Hepatic failure	88.10	16.03	4	169157	68735	110351403
Medication error	87.79	16.03	26	169135	105340	110314798
Mast cell activation syndrome	87.49	16.03	44	169117	1484	110418654
Hepatitis	87.35	16.03	16	169145	90038	110330100
Symptom recurrence	86.63	16.03	66	169095	4706	110415432
Rhonchi	85.37	16.03	64	169097	4454	110415684
Cholestasis	85.24	16.03	3	169158	64515	110355623
Dyspnoea at rest	85.16	16.03	83	169078	8263	110411875
Anaphylactic shock	84.65	16.03	220	168941	51326	110368812
Mental status changes	84.43	16.03	9	169152	76113	110344025
Sinus disorder	84.29	16.03	167	168994	32561	110387577
Hepatic function abnormal	84.21	16.03	17	169144	89278	110330860
Cognitive disorder	83.91	16.03	16	169145	87495	110332643
Hypoglycaemia	82.62	16.03	37	169124	116067	110304071
Total lung capacity increased	82.61	16.03	66	169095	5046	110415092
Blood lactic acid increased	82.29	16.03	111	169050	15710	110404428
Bladder pain	82.03	16.03	52	169109	2753	110417385
Melaena	82.02	16.03	6	169155	68751	110351387
Asthma-chronic obstructive pulmonary disease overlap syndrome	82.01	16.03	72	169089	6272	110413866
Blood iron decreased	81.07	16.03	122	169039	19092	110401046
Pulmonary congestion	80.95	16.03	159	169002	30807	110389331
Frequent bowel movements	80.32	16.03	8	169153	71382	110348756
Hypocalcaemia	80.04	16.03	5	169156	65361	110354777
Gastrointestinal disorder	79.46	16.03	156	169005	241796	110178342
Wrist fracture	79.37	16.03	104	169057	14313	110405825
Migraine	79.06	16.03	491	168670	171161	110248977
Cold urticaria	79.02	16.03	25	169136	234	110419904
Crepitations	78.87	16.03	90	169071	10745	110409393
Cryopyrin associated periodic syndrome	77.81	16.03	31	169130	594	110419544
Respiratory tract inflammation	77.79	16.03	36	169125	1007	110419131
Burning sensation	77.75	16.03	258	168903	68954	110351184
Night sweats	77.66	16.03	55	169106	133928	110286210
Chronic kidney disease	77.43	16.03	12	169149	76279	110343859
Colitis	77.01	16.03	30	169131	102293	110317845
Dry mouth	76.53	16.03	117	169044	199831	110220307
Hypercholesterolaemia	76.44	16.03	22	169139	90815	110329323
Lung diffusion test decreased	75.48	16.03	41	169120	1624	110418514
Swollen tongue	75.07	16.03	233	168928	60129	110360009
Serum sickness	73.59	16.03	58	169103	4348	110415790
Injury	73.50	16.03	98	169063	177167	110242971
Drug reaction with eosinophilia and systemic symptoms	72.64	16.03	18	169143	82077	110338061
Unresponsive to stimuli	72.16	16.03	7	169154	63783	110356355
Agranulocytosis	71.95	16.03	6	169155	61754	110358384
Liver function test abnormal	71.94	16.03	10	169151	68940	110351198
Nervousness	71.87	16.03	168	168993	36683	110383455
Hepatic cytolysis	71.23	16.03	3	169158	55050	110365088
Epilepsy	71.20	16.03	32	169129	100177	110319961
Blepharospasm	70.93	16.03	3	169158	54848	110365290
Hospitalisation	70.82	16.03	68	169093	142425	110277713
Wrong technique in product usage process	70.76	16.03	293	168868	87055	110333083
Haemoglobin decreased	70.46	16.03	174	168987	248553	110171585
Live birth	70.36	16.03	11	169150	69473	110350665
Choking	69.61	16.03	100	169061	15010	110405128
Wound secretion	69.24	16.03	68	169093	6833	110413305
Ligament sprain	69.18	16.03	103	169058	15965	110404173
Hepatotoxicity	69.04	16.03	8	169153	63392	110356746
Hypokinesia	68.22	16.03	121	169040	21705	110398433
Bursitis	68.14	16.03	59	169102	129859	110290279
Hypoaesthesia oral	67.56	16.03	105	169056	16897	110403241
Blood cholesterol increased	67.06	16.03	112	169049	184673	110235465
Breast cancer	66.92	16.03	168	168993	38374	110381764
Blood pressure decreased	65.96	16.03	349	168812	114742	110305396
Plasma cell myeloma	65.96	16.03	9	169152	62927	110357211
Haematochezia	64.91	16.03	49	169112	115475	110304663
Injection site bruising	64.79	16.03	199	168962	51064	110369074
Taste disorder	64.76	16.03	11	169150	65376	110354762
Treatment noncompliance	64.59	16.03	16	169145	72974	110347164
Rash maculo-papular	64.28	16.03	17	169144	74205	110345933
Hallucination	63.74	16.03	38	169123	101394	110318744
Injection site discomfort	63.67	16.03	65	169096	6842	110413296
Bronchial obstruction	63.55	16.03	46	169115	3033	110417105
Cardiogenic shock	63.03	16.03	7	169154	57331	110362807
Ear pain	63.02	16.03	202	168959	53024	110367114
Blood creatinine increased	62.60	16.03	115	169046	182774	110237364
Nasal pruritus	62.58	16.03	30	169131	910	110419228
Concomitant disease aggravated	62.17	16.03	99	169062	16265	110403873
Mouth swelling	62.04	16.03	66	169095	7288	110412850
Blood alkaline phosphatase increased	61.90	16.03	16	169145	70919	110349219
Pleural effusion	61.49	16.03	111	169050	177598	110242540
Multiple sclerosis relapse	61.04	16.03	4	169157	50236	110369902
Platelet count increased	60.29	16.03	128	169033	26206	110393932
Urinary retention	60.27	16.03	16	169145	69667	110350471
Therapy non-responder	60.24	16.03	92	169069	157215	110262923
Infection	60.21	16.03	317	168844	361883	110058255
Limb injury	60.13	16.03	159	169002	37477	110382661
Intentional product misuse	59.79	16.03	69	169092	132835	110287303
Urticaria chronic	58.82	16.03	27	169134	741	110419397
Sputum increased	58.32	16.03	57	169104	5694	110414444
Sensation of foreign body	57.64	16.03	66	169095	7909	110412229
Onychomadesis	57.42	16.03	3	169158	45660	110374478
Eosinophilia	57.27	16.03	207	168954	57729	110362409
Lung hyperinflation	57.03	16.03	38	169123	2191	110417947
Hyposmia	56.83	16.03	30	169131	1121	110419017
Pharyngeal oedema	56.48	16.03	95	169066	16333	110403805
Idiopathic urticaria	56.42	16.03	20	169141	273	110419865
Tubulointerstitial nephritis	56.33	16.03	8	169153	54276	110365862
Fibromyalgia	56.27	16.03	110	169051	170799	110249339
Expiratory reserve volume decreased	56.20	16.03	17	169144	135	110420003
Colitis ulcerative	56.07	16.03	24	169137	77339	110342799
Insomnia	55.75	16.03	817	168344	359773	110060365
Feeling hot	55.48	16.03	281	168880	90825	110329313
Musculoskeletal stiffness	55.29	16.03	230	168931	279592	110140546
Lower limb fracture	55.21	16.03	23	169138	75325	110344813
Decompression sickness	55.15	16.03	16	169145	108	110420030
Gamma-glutamyltransferase increased	55.11	16.03	13	169148	61296	110358842
Periorbital swelling	54.78	16.03	54	169107	5451	110414687
Polymyalgia rheumatica	54.67	16.03	58	169103	6384	110413754
Vaccination site pain	54.38	16.03	23	169138	516	110419622
Seizure	54.22	16.03	166	168995	221019	110199119
Ear discomfort	54.11	16.03	76	169085	11173	110408965
Coagulation factor deficiency	53.98	16.03	20	169141	312	110419826
Cystic fibrosis	53.89	16.03	50	169111	4681	110415457
Food intolerance	53.81	16.03	49	169112	4478	110415660
Forced expiratory volume increased	53.46	16.03	16	169145	122	110420016
Sciatica	53.45	16.03	38	169123	92361	110327777
Grip strength decreased	53.31	16.03	28	169133	80146	110339992
Osteoarthritis	53.10	16.03	126	169035	182497	110237641
Bronchial wall thickening	53.10	16.03	42	169119	3165	110416973
Hypercalcaemia	53.09	16.03	5	169156	46652	110373486
Pneumonia aspiration	53.09	16.03	29	169132	81204	110338934
Factor V Leiden mutation	52.83	16.03	19	169142	271	110419867
Nail disorder	52.64	16.03	12	169149	57923	110362215
Decreased activity	52.58	16.03	74	169087	10900	110409238
Acute respiratory distress syndrome	52.57	16.03	9	169152	53189	110366949
Knee arthroplasty	52.36	16.03	17	169144	64931	110355207
Diabetic ketoacidosis	52.15	16.03	3	169158	42055	110378083
Cytomegalovirus infection	52.10	16.03	10	169151	54434	110365704
Hip arthroplasty	51.85	16.03	11	169150	55802	110364336
Quality of life decreased	51.48	16.03	84	169077	14085	110406053
Wound complication	51.34	16.03	55	169106	6122	110414016
Orthostatic hypotension	50.55	16.03	19	169142	66230	110353908
Coagulation factor V level abnormal	50.55	16.03	16	169145	150	110419988
Wound infection	50.35	16.03	44	169117	96421	110323717
Pancreatitis acute	49.98	16.03	15	169146	60259	110359879
Hereditary angioedema	49.94	16.03	58	169103	7056	110413082
Accident	49.75	16.03	72	169089	10880	110409258
Bacteraemia	49.71	16.03	4	169157	42386	110377752
Hypervolaemia	49.70	16.03	8	169153	49452	110370686
Needle issue	49.56	16.03	94	169067	17746	110402392
Cardiac failure	49.50	16.03	136	169025	187490	110232648
Blood immunoglobulin E abnormal	49.48	16.03	12	169149	35	110420103
Laboratory test abnormal	49.43	16.03	5	169156	44074	110376064
Lung opacity	49.18	16.03	74	169087	11578	110408560
Clostridium difficile colitis	49.00	16.03	5	169156	43773	110376365
Cerebral haemorrhage	48.96	16.03	19	169142	64949	110355189
Blood urea increased	48.72	16.03	12	169149	54945	110365193
Nasal disorder	48.71	16.03	45	169116	4189	110415949
Chronic spontaneous urticaria	48.65	16.03	33	169128	1960	110418178
Hallucination, visual	48.58	16.03	3	169158	39602	110380536
Hyperventilation	48.42	16.03	64	169097	8883	110411255
Claustrophobia	48.00	16.03	30	169131	1549	110418589
Psoriasis	47.93	16.03	88	169073	139905	110280233
Deep vein thrombosis	47.83	16.03	88	169073	139799	110280339
Psychotic disorder	47.40	16.03	10	169151	50927	110369211
Skin lesion	47.29	16.03	180	168981	51451	110368687
Respiratory rate decreased	47.28	16.03	53	169108	6205	110413933
Terminal insomnia	47.10	16.03	32	169129	1906	110418232
Forced expiratory volume abnormal	46.89	16.03	15	169146	146	110419992
Fluid retention	46.86	16.03	45	169116	94262	110325876
Sedation	46.83	16.03	24	169137	69659	110350479
Depression	46.66	16.03	289	168872	317046	110103092
Altered state of consciousness	46.60	16.03	15	169146	57611	110362527
Head deformity	46.40	16.03	13	169148	76	110420062
Drug withdrawal syndrome	46.32	16.03	3	169158	38051	110382087
Therapeutic response decreased	46.29	16.03	279	168882	96220	110323918
Adverse drug reaction	46.20	16.03	56	169105	105503	110314635
Ventricular tachycardia	46.16	16.03	10	169151	49999	110370139
Hepatic cirrhosis	45.88	16.03	23	169138	67603	110352535
Myelodysplastic syndrome	45.49	16.03	3	169158	37481	110382657
Muscle tension dysphonia	45.31	16.03	17	169144	275	110419863
Acute myocardial infarction	45.21	16.03	37	169124	83740	110336398
Anaphylactoid reaction	45.18	16.03	54	169107	6772	110413366
Otorrhoea	45.07	16.03	33	169128	2215	110417923
Pneumocystis jirovecii pneumonia	45.05	16.03	6	169155	42729	110377409
Upper limb fracture	44.93	16.03	99	169062	20789	110399349
Product dose omission issue	44.70	16.03	716	168445	321066	110099072
Gastrooesophageal reflux disease	44.56	16.03	446	168715	179530	110240608
Upper respiratory tract infection	44.17	16.03	348	168813	130980	110289158
Hypoacusis	43.90	16.03	136	169025	35055	110385083
Blood creatine phosphokinase increased	43.67	16.03	29	169132	73048	110347090
Disorientation	43.67	16.03	27	169134	70644	110349494
Osteonecrosis of jaw	43.52	16.03	10	169151	48007	110372131
Injection related reaction	43.04	16.03	28	169133	1550	110418588
Anxiety	42.87	16.03	754	168407	344324	110075814
Skin ulcer	42.65	16.03	22	169139	63623	110356515
Lupus-like syndrome	42.36	16.03	6	169155	40786	110379352
Coronary artery disease	42.11	16.03	29	169132	71661	110348477
Stevens-Johnson syndrome	42.05	16.03	10	169151	46891	110373247
Pulmonary pain	42.01	16.03	50	169111	6243	110413895
Jaundice	41.94	16.03	19	169142	59217	110360921
Aphasia	41.66	16.03	19	169142	58978	110361160
Onychomycosis	41.61	16.03	5	169156	38526	110381612
Vasculitis	41.43	16.03	135	169026	35738	110384400
Generalised tonic-clonic seizure	41.19	16.03	16	169145	54664	110365474
Urticarial vasculitis	41.18	16.03	23	169138	963	110419175
Feeling cold	41.15	16.03	130	169031	33857	110386281
Cerebral infarction	41.03	16.03	14	169147	51824	110368314
Amnesia	40.97	16.03	61	169100	105347	110314791
Upper respiratory tract congestion	40.53	16.03	35	169126	2982	110417156
Myopathy	40.43	16.03	106	169055	24854	110395284
Status asthmaticus	40.43	16.03	23	169138	998	110419140
Acne	40.39	16.03	128	169033	33392	110386746
Movement disorder	40.26	16.03	135	169026	36269	110383869
Pulmonary hypertension	40.23	16.03	17	169144	55203	110364935
Gastroenteritis viral	40.19	16.03	122	169039	31104	110389034
Injection site swelling	40.05	16.03	194	168967	61596	110358542
Body temperature increased	40.05	16.03	178	168983	54535	110365603
Blood test abnormal	40.03	16.03	115	169046	28439	110391699
Injection site erythema	40.02	16.03	264	168897	93912	110326226
Inflammation	39.94	16.03	156	169005	193082	110227056
Neonatal hypoacusis	39.84	16.03	9	169152	17	110420121
Auditory neuropathy spectrum disorder	38.86	16.03	9	169152	20	110420118
Skin sensitisation	38.47	16.03	23	169138	1096	110419042
Sarcoidosis	38.37	16.03	69	169092	12510	110407628
Blister	38.32	16.03	198	168963	227178	110192960
Paraesthesia oral	38.24	16.03	126	169035	33545	110386593
Abdominal pain	37.99	16.03	554	168607	512435	109907703
Ear infection	37.85	16.03	193	168968	62539	110357599
Choking sensation	37.75	16.03	40	169121	4396	110415742
Spirometry abnormal	37.23	16.03	44	169117	5453	110414685
Dyskinesia	37.22	16.03	16	169145	51430	110368708
Pulmonary embolism	37.15	16.03	185	168976	214289	110205849
Lymphopenia	37.14	16.03	8	169153	40162	110379976
Respiration abnormal	36.79	16.03	59	169102	9750	110410388
Sputum retention	36.79	16.03	24	169137	1335	110418803
Pancreatitis	36.48	16.03	54	169107	93479	110326659
Heart rate abnormal	36.46	16.03	50	169111	7188	110412950
Dermoid cyst	36.46	16.03	17	169144	484	110419654
Tympanosclerosis	36.36	16.03	10	169151	54	110420084
Device related infection	36.28	16.03	8	169153	39511	110380627
Fear of disease	36.22	16.03	24	169137	1371	110418767
Agitation	36.14	16.03	74	169087	112977	110307161
Acute respiratory failure	36.14	16.03	37	169124	75223	110344915
Coagulopathy	36.13	16.03	9	169152	40902	110379236
Blood calcium increased	36.01	16.03	83	169078	17957	110402181
Haematemesis	35.94	16.03	23	169138	59085	110361053
Dyspepsia	35.85	16.03	160	169001	190805	110229333
Hyperbilirubinaemia	35.67	16.03	3	169158	30668	110389470
Functional residual capacity increased	35.65	16.03	11	169150	94	110420044
Increased upper airway secretion	35.64	16.03	42	169119	5190	110414948
Ligament rupture	35.44	16.03	37	169124	3998	110416140
Ear swelling	35.42	16.03	28	169133	2108	110418030
Hypertension	35.32	16.03	558	168603	509526	109910612
Nasal inflammation	35.29	16.03	21	169140	992	110419146
Fatigue	35.18	16.03	2231	166930	1213727	109206411
Posterior reversible encephalopathy syndrome	35.11	16.03	5	169156	33856	110386282
Electrolyte imbalance	35.01	16.03	7	169154	37021	110383117
Red blood cell sedimentation rate increased	34.84	16.03	41	169120	78261	110341877
Pulmonary oedema	34.70	16.03	63	169098	100596	110319542
Eye allergy	34.43	16.03	21	169140	1038	110419100
Functional residual capacity decreased	34.16	16.03	10	169151	70	110420068
Drug eruption	33.85	16.03	20	169141	53639	110366499
Oral pruritus	33.84	16.03	33	169128	3287	110416851
Body temperature abnormal	33.76	16.03	32	169129	3077	110417061
Respiratory fume inhalation disorder	33.38	16.03	13	169148	234	110419904
Endocarditis fibroplastica	33.33	16.03	8	169153	22	110420116
Cystic fibrosis pancreatic	33.30	16.03	9	169152	45	110420093
Body mass index increased	33.28	16.03	28	169133	2302	110417836
Fibromuscular dysplasia	33.23	16.03	14	169147	311	110419827
Pigmentation disorder	33.11	16.03	48	169113	7263	110412875
Ventricular fibrillation	32.97	16.03	11	169150	41302	110378836
Full blood count decreased	32.68	16.03	5	169156	32094	110388044
Panic attack	32.60	16.03	108	169053	28832	110391306
Disability	32.45	16.03	4	169157	30219	110389919
Shock	32.38	16.03	21	169140	53567	110366571
Haematocrit decreased	32.33	16.03	32	169129	66085	110354053
Cytopenia	32.30	16.03	4	169157	30112	110390026
Administration site erythema	32.27	16.03	15	169146	424	110419714
Allergy to chemicals	31.94	16.03	32	169129	3293	110416845
Allergy test positive	31.80	16.03	19	169142	904	110419234
Abortion spontaneous	31.79	16.03	120	169041	34162	110385976
Circulatory collapse	31.70	16.03	13	169148	42980	110377158
Intentional self-injury	31.61	16.03	9	169152	37420	110382718
Blood calcium decreased	31.44	16.03	8	169153	35837	110384301
Tryptase increased	31.43	16.03	19	169142	924	110419214
Memory impairment	31.25	16.03	175	168986	196769	110223369
Toxic skin eruption	31.17	16.03	3	169158	27512	110392626
Injection site pruritus	31.14	16.03	158	169003	51100	110369038
Nephropathy toxic	31.12	16.03	3	169158	27475	110392663
Exposure during pregnancy	30.99	16.03	141	169020	167283	110252855
Ill-defined disorder	30.92	16.03	129	169032	156724	110263414
Injection site urticaria	30.89	16.03	76	169085	17139	110402999
Metastases to liver	30.84	16.03	8	169153	35378	110384760
Haemorrhage intracranial	30.70	16.03	4	169157	28965	110391173
Small intestinal obstruction	30.65	16.03	6	169155	32207	110387931
Hypereosinophilic syndrome	30.52	16.03	18	169143	836	110419302
Bronchial irritation	30.50	16.03	9	169152	65	110420073
Abnormal behaviour	30.11	16.03	11	169150	39028	110381110
Respiratory tract irritation	30.02	16.03	17	169144	731	110419407
Lymphocyte count decreased	30.00	16.03	26	169135	57217	110362921
Dry throat	29.89	16.03	52	169109	9186	110410952
Bacterial disease carrier	29.83	16.03	26	169135	2243	110417895
Urticaria pressure	29.80	16.03	9	169152	71	110420067
Reaction to azo-dyes	29.79	16.03	7	169154	17	110420121
Skin burning sensation	29.72	16.03	87	169074	21738	110398400
Skin laceration	29.54	16.03	116	169045	33637	110386501
Metastases to bone	29.52	16.03	6	169155	31366	110388772
Lung disorder	29.41	16.03	412	168749	179635	110240503
Procedural pain	29.35	16.03	120	169041	35445	110384693
Drug ineffective for unapproved indication	29.06	16.03	72	169089	102766	110317372
Sinus tachycardia	28.90	16.03	16	169145	44477	110375661
Femur fracture	28.87	16.03	16	169145	44453	110375685
Urosepsis	28.59	16.03	6	169155	30669	110389469
Upper airway obstruction	28.55	16.03	23	169138	1779	110418359
Limb discomfort	28.47	16.03	131	169030	40723	110379415
Malnutrition	28.35	16.03	4	169157	27275	110392863
Respiratory depression	28.34	16.03	7	169154	31994	110388144
Product use in unapproved indication	28.15	16.03	498	168663	446879	109973259
Foot deformity	27.96	16.03	20	169141	48460	110371678
Device dislocation	27.95	16.03	7	169154	31697	110388441
Gastric ulcer	27.85	16.03	13	169148	39814	110380324
Red blood cell count decreased	27.77	16.03	36	169125	65887	110354251
COVID-19 pneumonia	27.76	16.03	11	169150	37132	110383006
Nocturnal dyspnoea	27.75	16.03	23	169138	1852	110418286
Joint injury	27.69	16.03	128	169033	39866	110380272
Respiratory arrest	27.61	16.03	29	169132	58270	110361868
Ejection fraction decreased	27.59	16.03	14	169147	40866	110379272
Withdrawal syndrome	27.53	16.03	7	169154	31373	110388765
Subarachnoid haemorrhage	27.29	16.03	6	169155	29696	110390442
Pain in jaw	27.12	16.03	23	169138	51154	110368984
Sputum culture	27.10	16.03	12	169149	302	110419836
Asthma exercise induced	26.90	16.03	11	169150	226	110419912
Eosinophil count abnormal	26.74	16.03	18	169143	1056	110419082
Peak expiratory flow rate abnormal	26.52	16.03	9	169152	107	110420031
Local reaction	26.50	16.03	16	169145	776	110419362
Pericardial effusion	26.50	16.03	29	169132	57188	110362950
Exostosis	26.45	16.03	19	169142	45937	110374201
Red blood cell count increased	26.34	16.03	35	169126	4883	110415255
Sinus polyp	26.26	16.03	15	169146	656	110419482
Muscle rigidity	26.25	16.03	3	169158	24028	110396110
Escherichia infection	25.94	16.03	3	169158	23813	110396325
Ataxia	25.87	16.03	7	169154	30101	110390037
Injection site hypoaesthesia	25.85	16.03	15	169146	676	110419462
Vascular access site thrombosis	25.72	16.03	9	169152	118	110420020
Flushing	25.65	16.03	259	168902	104477	110315661
Nasal mucosal disorder	25.61	16.03	22	169139	1861	110418277
Diaphragmatic disorder	25.58	16.03	22	169139	1864	110418274
Toxic epidermal necrolysis	24.92	16.03	30	169131	56697	110363441
Metastases to lung	24.89	16.03	3	169158	23060	110397078
Polyneuropathy	24.73	16.03	9	169152	32003	110388135
Mitral valve incompetence	24.70	16.03	10	169151	33319	110386819
Sinonasal obstruction	24.64	16.03	12	169149	377	110419761
Metastases to central nervous system	24.54	16.03	3	169158	22814	110397324
Finger deformity	24.41	16.03	10	169151	33082	110387056
Glomerular filtration rate decreased	24.38	16.03	7	169154	28949	110391189
Mental impairment	24.29	16.03	3	169158	22636	110397502
Atrial flutter	24.21	16.03	4	169157	24258	110395880
Exposure to fungus	24.17	16.03	10	169151	212	110419926
Joint stiffness	24.16	16.03	41	169120	67202	110352936
Acidosis	24.14	16.03	3	169158	22528	110397610
Cardiac failure acute	23.95	16.03	4	169157	24074	110396064
Sense of oppression	23.95	16.03	20	169141	1628	110418510
Skin reaction	23.90	16.03	79	169082	21065	110399073
Bronchomalacia	23.86	16.03	11	169150	305	110419833
Chills	23.84	16.03	417	168744	190163	110229975
Immunisation reaction	23.66	16.03	15	169146	794	110419344
Forearm fracture	23.65	16.03	14	169147	655	110419483
Sinus headache	23.62	16.03	37	169124	5995	110414143
Tachycardia	23.60	16.03	227	168934	226418	110193720
Bronchial disorder	23.57	16.03	25	169136	2751	110417387
Exercise tolerance decreased	23.51	16.03	55	169106	12012	110408126
Blood lactate dehydrogenase increased	23.40	16.03	20	169141	44314	110375824
Pharyngitis	23.40	16.03	88	169073	25010	110395128
Poor quality sleep	23.38	16.03	95	169066	27982	110392156
Vascular access site infection	23.37	16.03	9	169152	157	110419981
Photosensitivity reaction	23.26	16.03	89	169072	25500	110394638
Urinary tract infection	23.22	16.03	355	168806	325927	110094211
Injection site eczema	23.21	16.03	8	169153	100	110420038
Ileus	23.13	16.03	9	169152	30720	110389418
Steroid diabetes	23.08	16.03	34	169127	5220	110414918
Nerve compression	23.07	16.03	52	169109	11085	110409053
Diabetes mellitus	23.03	16.03	243	168918	99138	110321000
Blood potassium increased	23.02	16.03	11	169150	33238	110386900
Bruxism	22.93	16.03	33	169128	4961	110415177
Speech disorder	22.85	16.03	167	168994	61402	110358736
Laryngeal oedema	22.83	16.03	48	169113	9759	110410379
Hypothermia	22.82	16.03	6	169155	26296	110393842
Nasal septum deviation	22.69	16.03	22	169139	2176	110417962
Extrapyramidal disorder	22.49	16.03	8	169153	28859	110391279
Allergy to plants	22.46	16.03	15	169146	868	110419270
Skin discolouration	22.38	16.03	140	169021	48906	110371232
Right ventricular failure	22.37	16.03	6	169155	25948	110394190
Type 2 diabetes mellitus	22.26	16.03	169	168992	177063	110243075
Therapy interrupted	22.26	16.03	26	169135	49796	110370342
Dysgeusia	22.21	16.03	46	169115	69939	110350199
Arthropod sting	22.06	16.03	18	169143	1418	110418720
Type I hypersensitivity	22.02	16.03	37	169124	6356	110413782
Chronic rhinosinusitis with nasal polyps	21.88	16.03	8	169153	120	110420018
Serum ferritin decreased	21.88	16.03	25	169136	2989	110417149
Suffocation feeling	21.72	16.03	21	169140	2070	110418068
Device defective	21.71	16.03	28	169133	3794	110416344
Autoimmune disorder	21.67	16.03	42	169119	65441	110354697
Pleuritic pain	21.66	16.03	64	169097	16076	110404062
Hydronephrosis	21.55	16.03	3	169158	20662	110399476
Abdominal pain upper	21.51	16.03	390	168771	348721	110071417
Myocardial infarction	21.46	16.03	189	168972	191894	110228244
Fear	21.35	16.03	81	169080	23112	110397026
Eosinophilic oesophagitis	21.33	16.03	17	169144	1295	110418843
Left ventricular dysfunction	21.08	16.03	5	169156	23488	110396650
Lethargy	21.00	16.03	73	169088	93503	110326635
Lipoma	20.95	16.03	28	169133	3927	110416211
Blood potassium decreased	20.79	16.03	148	169013	53966	110366172
Klebsiella infection	20.64	16.03	3	169158	20006	110400132
Sputum abnormal	20.51	16.03	17	169144	1369	110418769
Skin necrosis	20.48	16.03	4	169157	21508	110398630
Dystonia	20.37	16.03	7	169154	25798	110394340
Product supply issue	20.36	16.03	27	169134	3759	110416379
Pneumococcal infection	20.29	16.03	19	169142	1800	110418338
Pharyngeal disorder	20.22	16.03	23	169138	2736	110417402
Blood urine present	20.16	16.03	82	169079	24163	110395975
Papulopustular rosacea	20.13	16.03	6	169155	45	110420093
Animal bite	20.05	16.03	24	169137	3015	110417123
Pharyngeal paraesthesia	20.00	16.03	28	169133	4104	110416034
Basal cell carcinoma	19.82	16.03	24	169137	45246	110374892
Radiculopathy	19.71	16.03	3	169158	19333	110400805
Haemolytic anaemia	19.68	16.03	4	169157	20916	110399222
Ligament pain	19.67	16.03	9	169152	245	110419893
Dizziness postural	19.67	16.03	58	169103	14551	110405587
Poisoning	19.59	16.03	10	169151	29095	110391043
Restlessness	19.58	16.03	35	169126	56224	110363914
Dizziness	19.55	16.03	1278	167883	696915	109723223
Mania	19.52	16.03	4	169157	20792	110399346
Impaired work ability	19.46	16.03	8	169153	26411	110393727
Blood sodium decreased	19.37	16.03	18	169143	38301	110381837
Dermatitis contact	19.37	16.03	56	169105	13897	110406241
Calculus urinary	19.34	16.03	24	169137	3128	110417010
Musculoskeletal pain	19.18	16.03	183	168978	182840	110237298
Physiotherapy chest	19.17	16.03	4	169157	4	110420134
Serum sickness-like reaction	19.12	16.03	13	169148	775	110419363
Oropharyngeal spasm	19.09	16.03	11	169150	489	110419649
Epistaxis	19.00	16.03	119	169042	130253	110289885
Nasal discomfort	18.97	16.03	34	169127	6147	110413991
Hepatitis acute	18.93	16.03	3	169158	18763	110401375
Pain	18.93	16.03	1701	167460	953254	109466884
Polyp	18.92	16.03	45	169116	9935	110410203
Epstein-Barr virus infection	18.89	16.03	3	169158	18735	110401403
Mucosal discolouration	18.86	16.03	14	169147	960	110419178
Gluten sensitivity	18.83	16.03	11	169150	502	110419636
Muscular weakness	18.83	16.03	267	168894	248201	110171937
Osteomyelitis	18.73	16.03	17	169144	36583	110383555
Acute coronary syndrome	18.71	16.03	6	169155	23106	110397032
General physical condition abnormal	18.67	16.03	38	169123	7552	110412586
Caffeine allergy	18.67	16.03	5	169156	24	110420114
Pulmonary alveolar haemorrhage	18.66	16.03	4	169157	20146	110399992
Drug level decreased	18.63	16.03	3	169158	18545	110401593
Maternal exposure before pregnancy	18.62	16.03	37	169124	7228	110412910
Conjunctivitis allergic	18.61	16.03	36	169125	6895	110413243
Tooth disorder	18.61	16.03	11	169150	29498	110390640
Sudden death	18.60	16.03	7	169154	24388	110395750
Mouth ulceration	18.57	16.03	28	169133	48110	110372028
Lower gastrointestinal haemorrhage	18.55	16.03	3	169158	18483	110401655
Flatulence	18.55	16.03	32	169129	52117	110368021
Therapeutic response shortened	18.54	16.03	92	169069	29491	110390647
Hemiparesis	18.47	16.03	24	169137	43879	110376259
Obesity	18.37	16.03	100	169061	113251	110306887
Urine output decreased	18.29	16.03	4	169157	19872	110400266
Leukocytosis	18.27	16.03	34	169127	53794	110366344
Iron deficiency anaemia	18.22	16.03	13	169148	31546	110388592
Myocardial ischaemia	18.21	16.03	9	169152	26675	110393463
Pleural rub	18.18	16.03	6	169155	65	110420073
Skin swelling	18.18	16.03	39	169122	8041	110412097
Oxygen saturation decreased	18.06	16.03	339	168822	156643	110263495
Tricuspid valve incompetence	17.96	16.03	7	169154	23866	110396272
Dialysis	17.95	16.03	4	169157	19615	110400523
Drug resistance	17.93	16.03	37	169124	56337	110363801
Snoring	17.93	16.03	35	169126	6749	110413389
Congenital anomaly	17.91	16.03	14	169147	1037	110419101
Functional residual capacity abnormal	17.90	16.03	4	169157	7	110420131
Chronic sinusitis	17.90	16.03	81	169080	25003	110395135
Delusion	17.81	16.03	7	169154	23748	110396390
Enterobiasis	17.78	16.03	6	169155	70	110420068
Coeliac disease	17.77	16.03	24	169137	43163	110376975
Vaginal discharge	17.76	16.03	3	169158	17905	110402233
Proteinuria	17.75	16.03	21	169140	39997	110380141
Brain oedema	17.71	16.03	13	169148	31085	110389053
Gait inability	17.62	16.03	129	169032	136247	110283891
Underdose	17.56	16.03	45	169116	63509	110356629
Polyuria	17.53	16.03	3	169158	17735	110402403
Lower respiratory tract infection bacterial	17.51	16.03	14	169147	1071	110419067
Ehlers-Danlos syndrome	17.41	16.03	9	169152	322	110419816
Pertussis	17.37	16.03	15	169146	1278	110418860
Dermatitis bullous	17.24	16.03	3	169158	17526	110402612
Urticaria physical	17.24	16.03	4	169157	9	110420129
Allergy to metals	17.18	16.03	12	169149	748	110419390
Haematuria	17.15	16.03	67	169094	82938	110337200
Bronchial hyperreactivity	17.13	16.03	24	169137	3520	110416618
Splenomegaly	17.12	16.03	8	169153	24490	110395648
Breath sounds	17.11	16.03	7	169154	144	110419994
Lymphostasis	17.08	16.03	5	169156	35	110420103
Loss of personal independence in daily activities	17.03	16.03	147	169014	149873	110270265
Food poisoning	16.99	16.03	33	169128	6339	110413799
Peak expiratory flow rate increased	16.94	16.03	4	169157	10	110420128
Vocal cord dysfunction	16.94	16.03	13	169148	937	110419201
Suicidal ideation	16.85	16.03	80	169081	93857	110326281
Parasitic gastroenteritis	16.80	16.03	8	169153	239	110419899
Epiglottitis	16.76	16.03	13	169148	952	110419186
Fear of injection	16.70	16.03	40	169121	8871	110411267
Overweight	16.66	16.03	33	169128	6431	110413707
Nonspecific reaction	16.65	16.03	22	169139	3052	110417086
Intervertebral disc protrusion	16.56	16.03	85	169076	27613	110392525
Acute pulmonary oedema	16.52	16.03	3	169158	16993	110403145
Nasal turbinate abnormality	16.50	16.03	5	169156	40	110420098
Tongue oedema	16.49	16.03	38	169123	8218	110411920
Abscess oral	16.41	16.03	16	169145	1593	110418545
Dermatitis atopic	16.41	16.03	80	169081	25461	110394677
Visual acuity reduced	16.40	16.03	15	169146	32158	110387980
Head discomfort	16.39	16.03	65	169096	18935	110401203
Hypophagia	16.35	16.03	35	169126	52591	110367547
Anosmia	16.30	16.03	49	169112	12423	110407715
Lipohypertrophy	16.28	16.03	13	169148	993	110419145
Pulseless electrical activity	16.20	16.03	3	169158	16754	110403384
Jaw fracture	16.20	16.03	22	169139	3134	110417004
Paranoia	16.12	16.03	7	169154	22367	110397771
Acquired haemophilia	16.09	16.03	20	169141	2611	110417527
Cardiac infection	16.06	16.03	11	169150	664	110419474

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R03DX05	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES Other systemic drugs for obstructive airway diseases
MeSH PA	D018926	Anti-Allergic Agents
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D019141	Respiratory System Agents
FDA MoA	N0000175792	IgE-directed Antibody Interactions
FDA PE	N0000175793	Decreased IgE Activity
FDA EPC	N0000175794	Anti-IgE
CHEBI has role	CHEBI:22587	antiviral agent
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:50177	dermatologic drug
CHEBI has role	CHEBI:55323	antidiarrhoeal drug
CHEBI has role	CHEBI:65023	anti-asthmatic agent

Related Drugs by ATC class:

R03DX Other systemic drugs for obstructive airway diseases 10 drugs

amlexanoxbenralizumabdepemokimab-ulaaeprozinolfenspiridemepolizumabreslizumabroflumilastseratrodasttezepelumab

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Asthma	indication	195967001	DOID:2841
Chronic idiopathic urticaria	indication	302162004
Seasonal allergic rhinitis	indication	367498001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Ig epsilon chain C region	Antibody	P01854	IGHE_HUMAN	ANTIBODY BINDING	Kd	8.16		IUPHAR	DRUG LABEL

External reference:

ID	Source
D05251	KEGG_DRUG
4021399	VUID
N0000148817	NUI
4021399	VANDF
CHEBI:749497	CHEBI
CHEMBL1201589	ChEMBL_ID
6890	IUPHAR_LIGAND_ID
DB00043	DRUGBANK_ID
302379	RXNORM
17379	MMSL
46992	MMSL
d04881	MMSL
000571	NDDF
406442003	SNOMEDCT_US
406443008	SNOMEDCT_US
C0966225	UMLSCUI
D000069444	MESH_DESCRIPTOR_UI
8039	INN_ID
2P471X1Z11	UNII
C401983	MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
XOLAIR	HUMAN PRESCRIPTION DRUG LABEL	1	50242-040	INJECTION, SOLUTION	150 mg	SUBCUTANEOUS	BLA	32 sections
Xolair PFS	HUMAN PRESCRIPTION DRUG LABEL	1	50242-214	INJECTION, SOLUTION	75 mg	SUBCUTANEOUS	BLA	32 sections
Xolair PFS	HUMAN PRESCRIPTION DRUG LABEL	1	50242-215	INJECTION, SOLUTION	150 mg	SUBCUTANEOUS	BLA	32 sections
Xolair	HUMAN PRESCRIPTION DRUG LABEL	1	50242-227	INJECTION, SOLUTION	300 mg	SUBCUTANEOUS	BLA	32 sections