omalizumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
humanized origin 4972 242138-07-4

Description:

MoleculeDescription

Synonyms:

  • omalizumab
  • xolair
  • rhuMab-E25
  • olizumab
An anti-IgE, recombinant, humanized monoclonal antibody which specifically binds to the C epsilon3 domain of IMMUNOGLOBULIN E, the site of high-affinity IgE receptor binding. It inhibits the binding of IgE to MAST CELLS and BASOPHILS to reduce the severity of the allergic response and is used in the management of persistent allergic ASTHMA.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
16 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 25, 2005 EMA Novartis Europharm Ltd
June 20, 2003 FDA GENENTECH
Jan. 21, 2009 PMDA Novartis Pharma K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Urticaria 2814.26 16.35 2359 113076 163443 63210144
Forced expiratory volume decreased 1974.51 16.35 611 114824 4357 63369230
Anaphylactic reaction 1928.86 16.35 1303 114132 64797 63308790
Wheezing 1899.21 16.35 1493 113942 94102 63279485
No adverse event 1491.47 16.35 932 114503 40473 63333114
Cough 1306.02 16.35 2086 113349 290657 63082930
Sputum discoloured 1097.52 16.35 554 114881 15793 63357794
Obstructive airways disorder 1064.49 16.35 587 114848 20112 63353475
Productive cough 882.89 16.35 807 114628 62401 63311186
Dyspnoea 878.99 16.35 2912 112523 658401 62715186
Chest discomfort 717.30 16.35 940 114495 109029 63264558
Middle insomnia 692.72 16.35 374 115061 12269 63361318
Pruritus 559.52 16.35 1681 113754 359772 63013815
Sensitivity to weather change 544.14 16.35 265 115170 6972 63366615
Influenza 526.08 16.35 806 114629 107916 63265671
Angioedema 519.91 16.35 533 114902 47432 63326155
Heart rate increased 509.50 16.35 736 114699 93502 63280085
Blood immunoglobulin E increased 494.53 16.35 205 115230 3644 63369943
Nasal congestion 485.91 16.35 598 114837 65062 63308525
Blood pressure systolic increased 478.41 16.35 507 114928 46890 63326697
Oropharyngeal pain 454.94 16.35 699 114736 93788 63279799
Malaise 426.54 16.35 1687 113748 414267 62959320
Acute kidney injury 416.42 16.35 14 115421 263401 63110186
Toxicity to various agents 402.33 16.35 10 115425 247240 63126347
Asthmatic crisis 399.49 16.35 143 115292 1670 63371917
Infusion related reaction 381.31 16.35 15 115420 245506 63128081
Skin plaque 378.93 16.35 218 115217 8102 63365485
Asthma 373.98 16.35 759 114676 126802 63246785
Throat tightness 365.33 16.35 327 115108 24560 63349027
Nasopharyngitis 356.89 16.35 1144 114291 253113 63120474
Blood pressure increased 356.13 16.35 859 114576 161203 63212384
Bronchitis 318.20 16.35 702 114733 124233 63249354
Pemphigus 312.82 16.35 4 115431 183722 63189865
Hypoventilation 306.95 16.35 157 115278 4597 63368990
Synovitis 302.34 16.35 8 115427 186910 63186677
Respiratory tract congestion 285.14 16.35 246 115189 17586 63356001
Neutropenia 284.90 16.35 7 115428 174998 63198589
Drug intolerance 282.80 16.35 104 115331 308557 63065030
Secretion discharge 281.66 16.35 209 115226 12022 63361565
Rhinorrhoea 280.81 16.35 460 114975 65117 63308470
Drug interaction 278.85 16.35 42 115393 229089 63144498
Nasal polyps 274.38 16.35 158 115277 5881 63367706
Hand deformity 273.57 16.35 3 115432 159454 63214133
Perfume sensitivity 269.89 16.35 87 115348 718 63372869
Bronchospasm 261.44 16.35 231 115204 17049 63356538
Arthropathy 251.72 16.35 59 115376 234733 63138854
Completed suicide 248.72 16.35 3 115432 145670 63227917
Body temperature decreased 242.48 16.35 238 115197 20081 63353506
Upper-airway cough syndrome 240.53 16.35 185 115250 11233 63362354
Glossodynia 239.07 16.35 24 115411 178852 63194735
Diarrhoea 237.04 16.35 602 114833 714764 62658823
Hepatic enzyme increased 235.19 16.35 42 115393 202286 63171301
Systemic lupus erythematosus 235.12 16.35 47 115388 208871 63164716
Seasonal allergy 234.52 16.35 237 115198 20713 63352874
Rales 233.69 16.35 190 115245 12507 63361080
Breath sounds abnormal 231.61 16.35 178 115257 10795 63362792
Treatment failure 223.52 16.35 45 115390 198998 63174589
Pulmonary function test decreased 222.42 16.35 119 115316 3828 63369759
Respiratory rate increased 219.66 16.35 189 115246 13459 63360128
Forced vital capacity decreased 218.64 16.35 80 115355 999 63372588
Rheumatoid arthritis 215.34 16.35 96 115339 253723 63119864
Pulmonary function test abnormal 210.15 16.35 90 115345 1740 63371847
Bronchopulmonary aspergillosis allergic 207.59 16.35 95 115340 2163 63371424
Pneumonia 207.45 16.35 1480 113955 455287 62918300
Joint swelling 205.92 16.35 176 115259 327490 63046097
Peak expiratory flow rate decreased 198.77 16.35 65 115370 564 63373023
Condition aggravated 198.25 16.35 265 115170 401952 62971635
Confusional state 198.01 16.35 91 115344 236289 63137298
Illness 193.79 16.35 332 115103 48727 63324860
Abdominal discomfort 192.46 16.35 180 115255 320705 63052882
Anaemia 191.29 16.35 152 115283 293278 63080309
Eosinophilic granulomatosis with polyangiitis 188.35 16.35 88 115347 2104 63371483
Hyponatraemia 187.98 16.35 3 115432 111897 63261690
Sneezing 187.48 16.35 197 115238 18021 63355566
Inappropriate schedule of product administration 186.66 16.35 511 114924 103454 63270133
Erythema 183.50 16.35 718 114717 175033 63198554
Dysphonia 182.55 16.35 318 115117 47296 63326291
Scratch 180.58 16.35 125 115310 6440 63367147
Stress 178.34 16.35 384 115051 66783 63306804
Throat irritation 177.47 16.35 276 115159 37371 63336216
Respiratory tract infection 174.84 16.35 289 115146 41194 63332393
Hypersensitivity 174.22 16.35 1016 114419 291669 63081918
Dust allergy 172.14 16.35 60 115375 644 63372943
Humidity intolerance 171.52 16.35 51 115384 311 63373276
White blood cell count decreased 167.99 16.35 26 115409 139078 63234509
Full blood count abnormal 162.90 16.35 242 115193 31475 63342112
Stomatitis 160.72 16.35 29 115406 138696 63234891
Anaphylactic shock 159.97 16.35 206 115229 23427 63350160
Pregnancy 158.44 16.35 259 115176 36577 63337010
Pericarditis 155.73 16.35 26 115409 131553 63242034
Eosinophil count increased 155.24 16.35 141 115294 10787 63362800
Platelet count decreased 151.47 16.35 17 115418 116105 63257482
Dehydration 151.03 16.35 63 115372 173291 63200296
Bronchial secretion retention 148.98 16.35 81 115354 2692 63370895
Respiratory disorder 147.18 16.35 259 115176 38823 63334764
Smoke sensitivity 146.63 16.35 48 115387 418 63373169
Helicobacter infection 146.22 16.35 5 115430 92780 63280807
Aphonia 145.22 16.35 131 115304 9932 63363655
Weight decreased 145.14 16.35 930 114505 275868 63097719
Thrombocytopenia 145.06 16.35 47 115388 151110 63222477
Bronchiectasis 144.18 16.35 162 115273 15980 63357607
Hypokalaemia 143.81 16.35 12 115423 103792 63269795
Constipation 143.44 16.35 119 115316 224824 63148763
Allergy to animal 142.16 16.35 61 115374 1185 63372402
Pharyngeal swelling 142.02 16.35 107 115328 6297 63367290
Vital capacity decreased 141.17 16.35 67 115368 1661 63371926
Myalgia 138.06 16.35 580 114855 145949 63227638
Swelling face 137.61 16.35 335 115100 63140 63310447
Lip swelling 135.74 16.35 220 115215 30843 63342744
Dyspnoea exertional 134.74 16.35 322 115113 59980 63313607
Nasal oedema 133.56 16.35 62 115373 1460 63372127
Reversible airways obstruction 131.14 16.35 65 115370 1777 63371810
Eye pruritus 129.91 16.35 165 115270 18506 63355081
Food allergy 129.46 16.35 130 115305 11271 63362316
Psoriatic arthropathy 128.39 16.35 10 115425 91510 63282077
Sinus pain 128.27 16.35 79 115356 3331 63370256
Viral infection 127.44 16.35 231 115204 35432 63338155
Lower respiratory tract congestion 127.10 16.35 74 115361 2812 63370775
Product use issue 125.98 16.35 129 115306 220391 63153196
Disease progression 125.38 16.35 34 115401 122724 63250863
Rhinitis allergic 122.79 16.35 128 115307 11599 63361988
Nausea 121.62 16.35 984 114451 853487 62520100
Sinus congestion 121.13 16.35 157 115278 17966 63355621
Influenza like illness 120.42 16.35 329 115106 66495 63307092
Exposure to allergen 120.25 16.35 38 115397 292 63373295
Swollen tongue 120.04 16.35 222 115213 34578 63339009
Impaired healing 119.70 16.35 21 115414 102521 63271066
Wound 118.88 16.35 75 115360 163188 63210399
Therapeutic product effect decreased 117.32 16.35 107 115328 193080 63180507
Alanine aminotransferase increased 115.30 16.35 24 115411 103746 63269841
Incorrect dose administered 114.87 16.35 302 115133 59666 63313921
Urticaria thermal 113.48 16.35 39 115396 400 63373187
Lower respiratory tract infection 113.36 16.35 509 114926 131798 63241789
Animal scratch 112.85 16.35 54 115381 1364 63372223
Urinary tract discomfort 112.10 16.35 43 115392 617 63372970
Hypotension 111.81 16.35 203 115232 272401 63101186
Paranasal sinus discomfort 110.32 16.35 79 115356 4297 63369290
Sinusitis 107.53 16.35 743 114692 225910 63147677
Injection site pain 105.73 16.35 492 114943 129308 63244279
Sputum culture positive 104.63 16.35 59 115376 2108 63371479
Total lung capacity decreased 104.22 16.35 59 115376 2124 63371463
Aspartate aminotransferase increased 102.13 16.35 20 115415 90257 63283330
Temperature intolerance 99.56 16.35 101 115334 8863 63364724
Nasal discharge discolouration 99.40 16.35 58 115377 2213 63371374
Cardiac failure congestive 95.51 16.35 25 115410 92408 63281179
Rubber sensitivity 95.39 16.35 57 115378 2274 63371313
Overdose 95.20 16.35 45 115390 115033 63258554
Blood pressure decreased 94.95 16.35 297 115138 64725 63308862
Neuropathy peripheral 94.72 16.35 44 115391 113623 63259964
Decreased appetite 94.21 16.35 197 115238 250855 63122732
Gastrointestinal haemorrhage 93.93 16.35 17 115418 81159 63292428
Migraine 93.36 16.35 404 115031 102942 63270645
Alveolar osteitis 92.66 16.35 41 115394 860 63372727
Headache 90.07 16.35 1633 113802 631608 62741979
Leukopenia 89.83 16.35 16 115419 77274 63296313
Serum sickness 89.52 16.35 59 115376 2801 63370786
Sepsis 89.21 16.35 88 115347 153035 63220552
Paraesthesia oral 87.71 16.35 139 115296 19117 63354470
Tunnel vision 86.83 16.35 43 115392 1173 63372414
Feeling abnormal 86.06 16.35 512 114923 147880 63225707
Pharyngeal oedema 85.72 16.35 115 115320 13606 63359981
Ear pruritus 85.16 16.35 65 115370 3900 63369687
Anaphylactoid reaction 84.32 16.35 63 115372 3660 63369927
Bradycardia 83.30 16.35 16 115419 73211 63300376
Lung disorder 83.30 16.35 276 115159 61985 63311602
Atrial fibrillation 82.95 16.35 55 115380 116581 63257006
Vomiting 82.80 16.35 637 114798 558980 62814607
Eczema 82.69 16.35 182 115253 32109 63341478
Septic shock 81.45 16.35 12 115423 66617 63306970
Mechanical urticaria 80.80 16.35 31 115404 445 63373142
Spirometry abnormal 80.61 16.35 26 115409 215 63373372
Neutrophil count decreased 79.57 16.35 6 115429 56400 63317187
Ear congestion 79.35 16.35 54 115381 2705 63370882
Eye swelling 79.26 16.35 150 115285 23768 63349819
Irritable bowel syndrome 78.37 16.35 26 115409 82386 63291201
Musculoskeletal stiffness 77.88 16.35 135 115300 184483 63189104
Multiple organ dysfunction syndrome 77.39 16.35 7 115428 56745 63316842
Feeling hot 77.23 16.35 234 115201 50120 63323467
Renal impairment 77.09 16.35 32 115403 88323 63285264
Respiratory tract inflammation 77.01 16.35 32 115403 572 63373015
Renal failure 76.48 16.35 61 115374 117591 63255996
Adverse event 76.34 16.35 15 115420 67544 63306043
Depressed level of consciousness 76.30 16.35 11 115424 62067 63311520
Hyperkalaemia 75.80 16.35 6 115429 54197 63319390
Bronchial obstruction 75.39 16.35 42 115393 1465 63372122
Mast cell activation syndrome 73.62 16.35 34 115401 791 63372796
Oropharyngeal discomfort 73.01 16.35 67 115368 5193 63368394
Increased bronchial secretion 71.79 16.35 43 115392 1723 63371864
Ear pain 71.31 16.35 184 115251 35934 63337653
Status asthmaticus 70.65 16.35 34 115401 870 63372717
Electrocardiogram QT prolonged 69.88 16.35 12 115423 59518 63314069
Sensation of foreign body 68.92 16.35 62 115373 4683 63368904
Multiple sclerosis relapse 68.83 16.35 5 115430 48473 63325114
Total lung capacity increased 68.31 16.35 46 115389 2264 63371323
International normalised ratio increased 68.24 16.35 4 115431 46421 63327166
Knee arthroplasty 68.05 16.35 9 115426 54197 63319390
Pulmonary mass 67.92 16.35 136 115299 22460 63351127
Mastocytosis 67.88 16.35 29 115406 557 63373030
Conjunctivitis allergic 66.35 16.35 33 115402 909 63372678
Suicide attempt 65.81 16.35 15 115420 60903 63312684
Interstitial lung disease 65.39 16.35 16 115419 61892 63311695
Wound secretion 64.49 16.35 59 115376 4555 63369032
Rhabdomyolysis 63.96 16.35 4 115431 43947 63329640
Frustration tolerance decreased 63.89 16.35 71 115364 6917 63366670
Cold urticaria 63.74 16.35 19 115416 117 63373470
C-reactive protein increased 62.95 16.35 48 115387 94659 63278928
Breast cancer 61.63 16.35 211 115224 48172 63325415
Ascites 61.46 16.35 3 115432 40725 63332862
Bladder pain 61.26 16.35 43 115392 2265 63371322
Lacrimation increased 60.61 16.35 123 115312 20508 63353079
Cardiac arrest 58.87 16.35 49 115386 92496 63281091
Hallucination 58.22 16.35 14 115421 54803 63318784
Liver function test abnormal 58.15 16.35 9 115426 48172 63325415
Polymyalgia rheumatica 55.98 16.35 50 115385 3741 63369846
Hypokinesia 55.91 16.35 95 115340 13841 63359746
Gastrointestinal disorder 55.30 16.35 96 115339 131143 63242444
Rhinitis 54.48 16.35 84 115351 11282 63362305
Death 54.39 16.35 428 115007 373953 62999634
Cognitive disorder 54.14 16.35 17 115418 55798 63317789
Weight increased 53.91 16.35 717 114718 260075 63113512
Mental status changes 53.68 16.35 5 115430 39594 63333993
Delirium 53.50 16.35 13 115422 50528 63323059
Cardio-respiratory arrest 53.46 16.35 21 115414 59938 63313649
Food intolerance 53.40 16.35 46 115389 3279 63370308
Forced expiratory flow decreased 51.98 16.35 15 115420 81 63373506
Auditory neuropathy spectrum disorder 51.64 16.35 12 115423 21 63373566
Lactic acidosis 51.46 16.35 5 115430 38282 63335305
Blood iron decreased 50.87 16.35 94 115341 14627 63358960
Quality of life decreased 50.79 16.35 71 115364 8732 63364855
Papule 50.62 16.35 57 115378 5634 63367953
Psoriasis 50.59 16.35 50 115385 86907 63286680
Skin ulcer 49.82 16.35 9 115426 43036 63330551
Hepatic failure 49.70 16.35 4 115431 35652 63337935
Crepitations 49.63 16.35 67 115368 7973 63365614
Blood bilirubin increased 49.53 16.35 5 115430 37135 63336452
Blood immunoglobulin E decreased 49.24 16.35 14 115421 71 63373516
Chronic spontaneous urticaria 49.19 16.35 29 115406 1128 63372459
Dyspnoea at rest 49.06 16.35 48 115387 4031 63369556
Coma 49.02 16.35 28 115407 64336 63309251
Hepatitis 49.01 16.35 7 115428 39781 63333806
Medication error 48.83 16.35 17 115418 52267 63321320
Wound complication 48.67 16.35 46 115389 3701 63369886
Adverse drug reaction 48.53 16.35 44 115391 79670 63293917
Abortion spontaneous 48.49 16.35 192 115243 47003 63326584
Throat clearing 48.35 16.35 38 115397 2381 63371206
Respiratory failure 48.13 16.35 69 115366 101789 63271798
Pulmonary congestion 47.83 16.35 101 115334 17317 63356270
Lung diffusion test decreased 47.83 16.35 24 115411 674 63372913
General physical health deterioration 47.81 16.35 196 115239 201206 63172381
Hypoacusis 47.63 16.35 123 115312 24028 63349559
Blood alkaline phosphatase increased 47.59 16.35 10 115425 42957 63330630
Pulmonary pain 47.56 16.35 44 115391 3446 63370141
Plasma cell myeloma 47.45 16.35 5 115430 35900 63337687
Drug-induced liver injury 47.45 16.35 8 115427 40214 63333373
Neonatal hypoacusis 47.43 16.35 11 115424 19 63373568
Hypoaesthesia oral 47.29 16.35 85 115350 12948 63360639
Product availability issue 46.80 16.35 47 115388 4074 63369513
Increased viscosity of bronchial secretion 46.54 16.35 19 115416 324 63373263
Chest X-ray abnormal 46.45 16.35 49 115386 4500 63369087
Multiple allergies 46.27 16.35 87 115348 13715 63359872
Pleural effusion 45.18 16.35 62 115373 93148 63280439
Blood creatinine increased 45.07 16.35 56 115379 87788 63285799
Urinary tract infection 44.52 16.35 290 115145 264394 63109193
Prescribed overdose 44.51 16.35 5 115430 34148 63339439
Anxiety 44.49 16.35 597 114838 216944 63156643
Ear discomfort 44.48 16.35 63 115372 7843 63365744
Decompression sickness 44.04 16.35 13 115422 77 63373510
Injection site discomfort 43.98 16.35 48 115387 4582 63369005
Unresponsive to stimuli 43.95 16.35 5 115430 33811 63339776
Hospitalisation 43.90 16.35 54 115381 85027 63288560
Chronic kidney disease 43.72 16.35 14 115421 45384 63328203
Haemoglobin decreased 43.69 16.35 128 115307 145357 63228230
Hypocalcaemia 43 16.35 4 115431 31709 63341878
Nasal pruritus 42.96 16.35 20 115415 474 63373113
Body temperature abnormal 42.83 16.35 33 115402 2008 63371579
Blood cholesterol increased 42.20 16.35 66 115369 93966 63279621
Liver disorder 41.39 16.35 23 115412 53664 63319923
Burning sensation 41.18 16.35 202 115233 54205 63319382
Hyperventilation 40.89 16.35 53 115382 6063 63367524
Melaena 40.72 16.35 4 115431 30361 63343226
Needle issue 40.66 16.35 70 115365 10306 63363281
Myopathy 40.62 16.35 73 115362 11118 63362469
FEV1/FVC ratio decreased 39.94 16.35 13 115422 111 63373476
Mouth swelling 39.66 16.35 46 115389 4694 63368893
Ligament sprain 39.62 16.35 78 115357 12722 63360865
Sinus disorder 39.43 16.35 116 115319 24437 63349150
Expiratory reserve volume decreased 39.06 16.35 10 115425 31 63373556
Cryopyrin associated periodic syndrome 39.03 16.35 17 115418 343 63373244
Laryngeal oedema 38.93 16.35 50 115385 5668 63367919
Otorrhoea 38.64 16.35 27 115408 1412 63372175
Infection 38.58 16.35 251 115184 228922 63144665
Pneumonia aspiration 38.33 16.35 8 115427 34532 63339055
Femur fracture 38.27 16.35 14 115421 41742 63331845
Rhonchi 38.09 16.35 34 115401 2542 63371045
Peak expiratory flow rate abnormal 37.88 16.35 12 115423 93 63373494
Choking 37.86 16.35 66 115369 9813 63363774
Nasal mucosal disorder 37.75 16.35 18 115417 451 63373136
Bronchial wall thickening 37.64 16.35 27 115408 1472 63372115
Dizziness 37.50 16.35 1035 114400 428890 62944697
Urticaria chronic 37.33 16.35 20 115415 645 63372942
Osteonecrosis of jaw 37.24 16.35 9 115426 35114 63338473
Feeling cold 36.61 16.35 111 115324 23777 63349810
Hepatic function abnormal 36.58 16.35 11 115424 37131 63336456
Head deformity 36.51 16.35 12 115423 106 63373481
Gastrooesophageal reflux disease 36.48 16.35 298 115137 95341 63278246
Concomitant disease aggravated 36.40 16.35 62 115373 9050 63364537
Fluid retention 36.26 16.35 33 115402 59653 63313934
Loss of personal independence in daily activities 35.89 16.35 77 115358 97213 63276374
Chills 35.85 16.35 339 115096 113039 63260548
Restrictive pulmonary disease 35.45 16.35 28 115407 1767 63371820
Orthostatic hypotension 35.09 16.35 11 115424 36149 63337438
Cystic fibrosis 34.54 16.35 36 115399 3260 63370327
Pain 34.51 16.35 1055 114380 739573 62634014
Upper respiratory tract infection 34.23 16.35 261 115174 81786 63291801
Urticarial vasculitis 34.18 16.35 19 115416 660 63372927
Limb injury 34.11 16.35 113 115322 25364 63348223
Nasal inflammation 33.44 16.35 17 115418 491 63373096
Nervousness 33.42 16.35 128 115307 30851 63342736
Oral pruritus 33.40 16.35 30 115405 2261 63371326
Osteoarthritis 33.10 16.35 78 115357 95265 63278322
Colitis 33.01 16.35 24 115411 48504 63325083
Live birth 32.79 16.35 4 115431 25626 63347961
Periorbital swelling 32.63 16.35 33 115402 2885 63370702
Laboratory test abnormal 32.54 16.35 5 115430 26907 63346680
Fall 32.39 16.35 510 114925 391824 62981763
Accident 32.37 16.35 47 115388 5985 63367602
Lung opacity 32.13 16.35 34 115401 3134 63370453
Functional residual capacity decreased 31.85 16.35 10 115425 75 63373512
Tryptase increased 31.75 16.35 15 115420 368 63373219
Accidental overdose 31.44 16.35 3 115432 23306 63350281
Eosinophilia 31.43 16.35 102 115333 22654 63350933
Insomnia 31.42 16.35 558 114877 214694 63158893
Flushing 30.84 16.35 238 115197 74849 63298738
Depression 30.68 16.35 220 115215 196272 63177315
Psychotic disorder 30.58 16.35 5 115430 25707 63347880
Serum sickness-like reaction 30.50 16.35 16 115419 494 63373093
Idiopathic urticaria 30.46 16.35 13 115422 249 63373338
Allergy test positive 30.26 16.35 17 115418 603 63372984
Treatment noncompliance 30.23 16.35 15 115420 37310 63336277
Pulmonary arterial hypertension 30.21 16.35 3 115432 22574 63351013
Gamma-glutamyltransferase increased 30.20 16.35 12 115423 34019 63339568
Heart rate abnormal 30.19 16.35 41 115394 4906 63368681
Suicidal ideation 29.76 16.35 42 115393 62379 63311208
Cystic fibrosis pancreatic 29.71 16.35 9 115426 59 63373528
Agranulocytosis 29.64 16.35 5 115430 25129 63348458
Blood calcium decreased 29.61 16.35 6 115429 26445 63347142
Joint range of motion decreased 29.50 16.35 11 115424 32417 63341170
Blood urea increased 29.50 16.35 6 115429 26373 63347214
Blood lactic acid increased 29.35 16.35 49 115386 7037 63366550
Skin lesion 29.19 16.35 122 115313 30599 63342988
Seizure 29.06 16.35 133 115302 132501 63241086
Symptom recurrence 28.99 16.35 25 115410 1785 63371802
Pain in jaw 28.95 16.35 22 115413 43474 63330113
Body temperature increased 28.80 16.35 139 115296 37053 63336534
Rectal haemorrhage 28.74 16.35 28 115407 49002 63324585
Intentional self-injury 28.40 16.35 6 115429 25681 63347906
Tooth disorder 28.35 16.35 8 115427 28149 63345438
Surgery 28.24 16.35 15 115420 35897 63337690
Movement disorder 28.05 16.35 95 115340 21566 63352021
Injection site hypoaesthesia 28.05 16.35 15 115420 482 63373105
Increased upper airway secretion 28.02 16.35 34 115401 3638 63369949
Coronary artery disease 27.79 16.35 12 115423 32365 63341222
Histamine level increased 27.52 16.35 7 115428 21 63373566
Respiration abnormal 27.42 16.35 45 115390 6372 63367215
Haematocrit decreased 27.35 16.35 19 115416 39321 63334266
Stevens-Johnson syndrome 27.23 16.35 6 115429 24944 63348643
Metastases to liver 27.23 16.35 5 115430 23634 63349953
Sense of oppression 27.13 16.35 19 115416 997 63372590
Red blood cell sedimentation rate increased 27.10 16.35 24 115411 43958 63329629
Musculoskeletal disorder 26.96 16.35 3 115432 20641 63352946
Ear infection 26.89 16.35 139 115296 38074 63335513
Exercise tolerance decreased 26.87 16.35 41 115394 5456 63368131
Pancreatitis acute 26.84 16.35 8 115427 27158 63346429
Ear swelling 26.65 16.35 22 115413 1479 63372108
Haematochezia 26.57 16.35 35 115400 53509 63320078
Device dislocation 26.45 16.35 7 115428 25698 63347889
Vocal cord dysfunction 26.45 16.35 15 115420 542 63373045
Discomfort 26.32 16.35 187 115248 167187 63206400
Frequent bowel movements 26.24 16.35 5 115430 23017 63350570
Muscle tension dysphonia 26.15 16.35 11 115424 203 63373384
Injection related reaction 26.08 16.35 17 115418 792 63372795
Therapeutic product effect incomplete 25.87 16.35 128 115307 124928 63248659
Respiratory rate decreased 25.80 16.35 32 115403 3503 63370084
Choking sensation 25.66 16.35 32 115403 3522 63370065
Rash maculo-papular 25.56 16.35 13 115422 31883 63341704
Injury 25.36 16.35 60 115375 73187 63300400
Drug reaction with eosinophilia and systemic symptoms 25.36 16.35 15 115420 33821 63339766
Hypervolaemia 25.25 16.35 10 115425 28403 63345184
Acute respiratory distress syndrome 25.01 16.35 6 115429 23528 63350059
Deep vein thrombosis 24.95 16.35 74 115361 83726 63289861
Sinus headache 24.83 16.35 40 115395 5576 63368011
Urinary retention 24.81 16.35 12 115423 30289 63343298
Lymphocyte count decreased 24.75 16.35 12 115423 30245 63343342
Vascular access site thrombosis 24.54 16.35 7 115428 36 63373551
Asthma-chronic obstructive pulmonary disease overlap syndrome 24.32 16.35 24 115411 2037 63371550
Urinary incontinence 24.27 16.35 14 115421 32000 63341587
Dyskinesia 24.25 16.35 14 115421 31988 63341599
Injection site scab 24.21 16.35 13 115422 421 63373166
Red blood cell count decreased 24.07 16.35 23 115412 40622 63332965
Nocturnal dyspnoea 23.97 16.35 19 115416 1205 63372382
Ehlers-Danlos syndrome 23.90 16.35 10 115425 182 63373405
Vasculitis 23.70 16.35 80 115355 18129 63355458
Forced expiratory volume abnormal 23.64 16.35 8 115427 78 63373509
Sputum culture 23.54 16.35 11 115424 263 63373324
Hypoglycaemia 23.45 16.35 46 115389 60019 63313568
Paraesthesia 23.28 16.35 408 115027 156558 63217029
Upper airway obstruction 23.22 16.35 15 115420 688 63372899
Hyposmia 23.14 16.35 15 115420 692 63372895
Reaction to azo-dyes 23.11 16.35 6 115429 20 63373567
Lymphopenia 23.10 16.35 3 115432 18324 63355263
Local reaction 23.10 16.35 15 115420 694 63372893
Lung hyperinflation 23.03 16.35 19 115416 1276 63372311
Oropharyngeal spasm 23.02 16.35 11 115424 277 63373310
Generalised tonic-clonic seizure 22.99 16.35 12 115423 29004 63344583
Type III immune complex mediated reaction 22.98 16.35 11 115424 278 63373309
Device related infection 22.91 16.35 7 115428 23385 63350202
Sarcoidosis 22.77 16.35 44 115391 7078 63366509
Functional residual capacity increased 22.69 16.35 8 115427 89 63373498
Forced expiratory volume increased 22.67 16.35 6 115429 22 63373565
Wrist fracture 22.59 16.35 65 115370 13522 63360065
Claustrophobia 22.55 16.35 17 115418 1001 63372586
Fear of disease 22.54 16.35 19 115416 1315 63372272
General physical condition abnormal 22.50 16.35 33 115402 4241 63369346
Blister 22.43 16.35 141 115294 129673 63243914
Photosensitivity reaction 22.34 16.35 69 115366 14925 63358662
Suffocation feeling 22.34 16.35 19 115416 1331 63372256
Bronchomalacia 22.08 16.35 10 115425 222 63373365
Vascular access site infection 22.01 16.35 7 115428 55 63373532
Chest pain 22.01 16.35 531 114904 215428 63158159
Colitis ulcerative 21.88 16.35 10 115425 26081 63347506
Pyrexia 21.83 16.35 1055 114380 469423 62904164
Lethargy 21.78 16.35 43 115392 55964 63317623
Osteomyelitis 21.77 16.35 10 115425 26010 63347577
Chronic obstructive pulmonary disease 21.61 16.35 191 115244 62495 63311092
Tongue pruritus 21.61 16.35 13 115422 525 63373062
Mite allergy 21.60 16.35 14 115421 646 63372941
Bacteraemia 21.49 16.35 3 115432 17345 63356242
Pleural rub 21.48 16.35 7 115428 60 63373527
Blood immunoglobulin E abnormal 21.43 16.35 5 115430 9 63373578
Night sweats 21.20 16.35 35 115400 48779 63324808
Pharyngeal paraesthesia 21.16 16.35 22 115413 1987 63371600
Selective IgA immunodeficiency 21.08 16.35 5 115430 10 63373577
Cytomegalovirus infection 21.01 16.35 6 115429 20946 63352641
Blood potassium increased 20.82 16.35 4 115431 18305 63355282
Injection site reaction 20.53 16.35 179 115256 58345 63315242
Coagulopathy 20.39 16.35 6 115429 20538 63353049
Speech disorder 20.29 16.35 135 115300 40494 63333093
Cerebral infarction 20.28 16.35 9 115426 23884 63349703
Sputum retention 20.27 16.35 13 115422 589 63372998
Respiratory fume inhalation disorder 20.23 16.35 8 115427 125 63373462
Respiratory moniliasis 20.16 16.35 9 115426 193 63373394
Flatulence 20.13 16.35 20 115415 34682 63338905
Pulmonary thrombosis 20.00 16.35 47 115388 8655 63364932
Foot deformity 19.97 16.35 13 115422 27840 63345747
Drug eruption 19.76 16.35 14 115421 28680 63344907
Pulmonary hypertension 19.74 16.35 23 115412 37100 63336487
Product quality issue 19.65 16.35 122 115313 35743 63337844
Ventricular tachycardia 19.53 16.35 6 115429 19973 63353614
Ligament pain 19.46 16.35 9 115426 210 63373377
Haematemesis 19.46 16.35 16 115419 30396 63343191
Injection site oedema 19.41 16.35 18 115417 1414 63372173
Disorientation 19.36 16.35 26 115409 39426 63334161
Altered state of consciousness 19.17 16.35 11 115424 25219 63348368
Urosepsis 19.15 16.35 5 115430 18519 63355068
Oropharyngitis fungal 19.11 16.35 6 115429 45 63373542
Pigmentation disorder 19.11 16.35 32 115403 4607 63368980
Lipohypertrophy 19.09 16.35 13 115422 652 63372935
Cardiac infection 19.02 16.35 12 115423 528 63373059
Bronchial disorder 19.02 16.35 17 115418 1273 63372314
Respiratory distress 18.92 16.35 116 115319 33835 63339752
Hyperlipidaemia 18.91 16.35 6 115429 19565 63354022
Croup infectious 18.88 16.35 12 115423 535 63373052
Disability 18.87 16.35 5 115430 18342 63355245
Abdominal pain upper 18.86 16.35 263 115172 206181 63167406
Ligament rupture 18.81 16.35 27 115408 3403 63370184
Acute respiratory failure 18.74 16.35 21 115414 34464 63339123
Hereditary angioedema 18.65 16.35 42 115393 7520 63366067
Sedation 18.61 16.35 26 115409 38783 63334804
Caffeine allergy 18.55 16.35 5 115430 20 63373567
Peripheral venous disease 18.43 16.35 3 115432 15474 63358113
Injection site bruising 18.42 16.35 135 115300 41775 63331812
Laryngospasm 18.34 16.35 25 115410 3003 63370584
Blood creatine phosphokinase increased 18.27 16.35 17 115418 30413 63343174
Allergy to chemicals 18.25 16.35 25 115410 3017 63370570
Vaccination site pain 18.20 16.35 8 115427 165 63373422
Labyrinthitis 18.08 16.35 22 115413 2361 63371226
Acute myocardial infarction 18.08 16.35 19 115416 32105 63341482
Aphasia 18.04 16.35 20 115415 32980 63340607
Sinus tachycardia 17.85 16.35 11 115424 24257 63349330
Blood sodium decreased 17.83 16.35 11 115424 24241 63349346
Red blood cell count increased 17.80 16.35 25 115410 3087 63370500
Lower limb fracture 17.78 16.35 11 115424 24210 63349377
Tubulointerstitial nephritis 17.69 16.35 7 115428 19896 63353691
Blood lactate dehydrogenase increased 17.68 16.35 10 115425 23106 63350481
Blood pressure fluctuation 17.63 16.35 36 115399 46281 63327306
Atopy 17.58 16.35 9 115426 264 63373323
Muscle disorder 17.51 16.35 32 115403 4937 63368650
Cerebral haemorrhage 17.49 16.35 18 115417 30711 63342876
Laryngitis 17.40 16.35 69 115366 16898 63356689
Therapy interrupted 17.38 16.35 20 115415 32435 63341152
Visual acuity reduced 17.33 16.35 9 115426 21817 63351770
Ileus 17.21 16.35 3 115432 14722 63358865
Drug ineffective for unapproved indication 17.17 16.35 22 115413 34041 63339546
Pancreatitis 17.13 16.35 40 115395 49015 63324572
Clostridium difficile colitis 17.07 16.35 8 115427 20561 63353026
Small intestinal obstruction 17.05 16.35 6 115429 18331 63355256
Oral pain 16.89 16.35 16 115419 28378 63345209
Osteonecrosis 16.85 16.35 12 115423 24518 63349069
Blood calcium increased 16.79 16.35 46 115389 9304 63364283
Abnormal behaviour 16.77 16.35 9 115426 21417 63352170
Complication associated with device 16.77 16.35 5 115430 16973 63356614
Tongue oedema 16.75 16.35 30 115405 4556 63369031
Nasal turbinate abnormality 16.75 16.35 5 115430 31 63373556
Macular degeneration 16.65 16.35 12 115423 24364 63349223
Urticaria pressure 16.61 16.35 5 115430 32 63373555
Solar urticaria 16.54 16.35 6 115429 73 63373514
Nasal obstruction 16.54 16.35 18 115417 1713 63371874
Drug dependence 16.50 16.35 88 115347 24395 63349192
Pharyngeal hypoaesthesia 16.45 16.35 9 115426 303 63373284
Eye allergy 16.41 16.35 14 115421 985 63372602
Nasal disorder 16.37 16.35 23 115412 2841 63370746

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Forced expiratory volume decreased 1032.44 20.79 300 38876 2903 34914852
Wheezing 1001.60 20.79 606 38570 40796 34876959
Urticaria 778.57 20.79 607 38569 61770 34855985
No adverse event 756.02 20.79 411 38765 22516 34895239
Cough 495.94 20.79 718 38458 149422 34768333
Nasopharyngitis 492.16 20.79 492 38684 69476 34848279
Obstructive airways disorder 456.33 20.79 258 38918 15236 34902519
Productive cough 413.60 20.79 341 38835 37472 34880283
Blood immunoglobulin E increased 412.04 20.79 141 39035 2405 34915350
Sputum discoloured 406.97 20.79 191 38985 7621 34910134
Nasal congestion 387.81 20.79 269 38907 22788 34894967
Dyspnoea 379.47 20.79 1098 38078 375684 34542071
Blood pressure increased 370.14 20.79 474 38702 87628 34830127
Chest discomfort 362.26 20.79 372 38804 54158 34863597
Middle insomnia 350.28 20.79 165 39011 6637 34911118
Anaphylactic reaction 346.30 20.79 288 38888 32013 34885742
Blood pressure systolic increased 333.54 20.79 245 38931 22707 34895048
Body temperature decreased 327.96 20.79 196 38980 12838 34904917
Asthma 318.22 20.79 310 38866 42346 34875409
Acute kidney injury 263.54 20.79 21 39155 304967 34612788
Influenza 263.47 20.79 301 38875 49365 34868390
Heart rate increased 254.55 20.79 286 38890 46057 34871698
Hypersensitivity 252.30 20.79 326 38850 60709 34857046
Respiratory tract congestion 244.52 20.79 125 39051 6014 34911741
Sensitivity to weather change 220.68 20.79 79 39097 1547 34916208
Drug interaction 211.66 20.79 10 39166 225936 34691819
Respiratory rate increased 211.20 20.79 134 39042 9760 34907995
Nasal polyps 207.85 20.79 85 39091 2418 34915337
Hypoventilation 207.67 20.79 93 39083 3321 34914434
Eosinophilic granulomatosis with polyangiitis 201.68 20.79 78 39098 1909 34915846
Malaise 195.86 20.79 552 38624 185273 34732482
Anaemia 180.90 20.79 24 39152 233311 34684444
Rhinorrhoea 177.30 20.79 179 38997 25489 34892266
Pruritus 168.70 20.79 441 38735 141540 34776215
Bronchopulmonary aspergillosis allergic 160.31 20.79 54 39122 875 34916880
Neutropenia 143.35 20.79 8 39168 156770 34760985
Sinusitis 141.85 20.79 202 38974 41200 34876555
Asthmatic crisis 139.56 20.79 42 39134 462 34917293
Lower respiratory tract infection 138.50 20.79 174 39002 31463 34886292
Oropharyngeal pain 134.84 20.79 182 38994 35303 34882452
Weight increased 134.80 20.79 312 38864 92721 34825034
Seasonal allergy 134.02 20.79 87 39089 6588 34911167
Bronchitis 132.51 20.79 197 38979 41766 34875989
Weight decreased 130.63 20.79 464 38712 175837 34741918
Thrombocytopenia 126.07 20.79 14 39162 156233 34761522
Forced vital capacity decreased 125.63 20.79 43 39133 733 34917022
Sinus congestion 122.32 20.79 77 39099 5528 34912227
Respiratory disorder 118.01 20.79 126 39050 19138 34898617
Dyspnoea exertional 108.73 20.79 183 38993 43096 34874659
Allergy to animal 108.60 20.79 33 39143 376 34917379
Hypotension 107.97 20.79 57 39119 221592 34696163
Diarrhoea 104.57 20.79 173 39003 389739 34528016
Smoke sensitivity 101.07 20.79 25 39151 120 34917635
Pulmonary function test decreased 97.81 20.79 64 39112 4911 34912844
Angioedema 95.16 20.79 159 39017 37215 34880540
Completed suicide 92.90 20.79 4 39172 98164 34819591
Renal failure 90.81 20.79 18 39158 130539 34787216
Confusional state 90.15 20.79 25 39151 144135 34773620
Pancytopenia 89.64 20.79 4 39172 95153 34822602
Disease progression 88.89 20.79 9 39167 108068 34809687
Food allergy 85.62 20.79 39 39137 1449 34916306
Malignant neoplasm progression 85.31 20.79 3 39173 88043 34829712
Eczema 83.22 20.79 103 39073 18333 34899422
Lower respiratory tract congestion 82.93 20.79 36 39140 1191 34916564
Constipation 81.56 20.79 26 39150 136956 34780799
Perfume sensitivity 81.20 20.79 20 39156 94 34917661
Hyponatraemia 79.48 20.79 3 39173 82688 34835067
Headache 78.82 20.79 437 38739 200198 34717557
Platelet count decreased 78.20 20.79 19 39157 119698 34798057
Peak expiratory flow rate decreased 77.26 20.79 20 39156 119 34917636
Nasal discharge discolouration 74.16 20.79 23 39153 282 34917473
Dehydration 73.33 20.79 27 39149 129942 34787813
Bronchospasm 72.53 20.79 74 39102 10657 34907098
Increased viscosity of bronchial secretion 72.40 20.79 21 39155 201 34917554
Throat tightness 72.27 20.79 66 39110 8292 34909463
Haemoglobin decreased 71.75 20.79 23 39153 120749 34797006
Injection site pain 71.52 20.79 144 39032 38861 34878894
Overdose 71.31 20.79 9 39167 91050 34826705
White blood cell count decreased 71.06 20.79 11 39165 95434 34822321
Breath sounds abnormal 70.84 20.79 60 39116 6821 34910934
Dust allergy 69.24 20.79 29 39147 877 34916878
Influenza like illness 68.25 20.79 116 39060 27518 34890237
Rhonchi 67.24 20.79 36 39140 1904 34915851
Multiple organ dysfunction syndrome 66.68 20.79 5 39171 76561 34841194
Stress 66.67 20.79 121 39055 30226 34887529
Sneezing 65.12 20.79 51 39125 5191 34912564
Temperature intolerance 64.79 20.79 43 39133 3379 34914376
Forced expiratory flow decreased 63.15 20.79 18 39158 161 34917594
Increased bronchial secretion 62.66 20.79 34 39142 1847 34915908
Blood creatinine increased 62.15 20.79 15 39161 94961 34822794
Humidity intolerance 61.24 20.79 12 39164 12 34917743
Sepsis 61.08 20.79 58 39118 166503 34751252
Illness 60.11 20.79 75 39101 13454 34904301
Discomfort 59.87 20.79 89 39087 18849 34898906
Eosinophil count increased 59.55 20.79 60 39116 8512 34909243
Rhinitis 58.65 20.79 52 39124 6286 34911469
Rales 57.63 20.79 63 39113 9820 34907935
Erythema 56.67 20.79 223 38953 88557 34829198
Throat irritation 55.77 20.79 64 39112 10521 34907234
Rhabdomyolysis 55.19 20.79 6 39170 68157 34849598
Cardiac arrest 54.18 20.79 20 39156 96139 34821616
Septic shock 54.10 20.79 8 39168 71826 34845929
Gastrointestinal haemorrhage 54.06 20.79 16 39160 88461 34829294
Chronic obstructive pulmonary disease 53.92 20.79 148 39028 48770 34868985
Aspartate aminotransferase increased 50.02 20.79 8 39168 67775 34849980
Renal impairment 49.43 20.79 22 39154 94491 34823264
Swelling face 49.32 20.79 91 39085 23014 34894741
Neuropathy peripheral 49.18 20.79 16 39160 83247 34834508
Acne 48.61 20.79 61 39115 11005 34906750
Eye swelling 48.61 20.79 58 39118 9937 34907818
Spirometry abnormal 48.14 20.79 21 39155 703 34917052
Ear infection 47.52 20.79 58 39118 10173 34907582
Decreased appetite 47.09 20.79 71 39105 166321 34751434
Maternal exposure timing unspecified 45.98 20.79 17 39159 366 34917389
Alanine aminotransferase increased 45.20 20.79 17 39159 80798 34836957
Skin plaque 44.99 20.79 39 39137 4575 34913180
Factor V Leiden mutation 44.20 20.79 12 39164 88 34917667
Drug intolerance 44.02 20.79 7 39169 59563 34858192
Arthralgia 43.69 20.79 333 38843 169708 34748047
Restrictive pulmonary disease 43.58 20.79 23 39153 1181 34916574
FEV1/FVC ratio decreased 43.28 20.79 12 39164 96 34917659
Lip swelling 43.04 20.79 70 39106 16010 34901745
Rhinitis allergic 43.00 20.79 32 39144 3018 34914737
Respiratory tract infection 42.53 20.79 78 39098 19634 34898121
Infusion related reaction 42.12 20.79 5 39171 53052 34864703
Bradycardia 41.95 20.79 16 39160 75402 34842353
Drug ineffective 41.61 20.79 730 38446 456021 34461734
Chronic sinusitis 41.61 20.79 28 39148 2251 34915504
Interstitial lung disease 41.37 20.79 11 39165 65271 34852484
Dermoid cyst 41.01 20.79 13 39163 172 34917583
Secretion discharge 40.41 20.79 41 39135 5864 34911891
Concomitant disease aggravated 39.78 20.79 40 39136 5661 34912094
Total lung capacity decreased 39.67 20.79 20 39156 933 34916822
Hypoglycaemia 39.09 20.79 7 39169 54633 34863122
Delirium 37.93 20.79 3 39173 43988 34873767
Pulmonary congestion 36.95 20.79 60 39116 13705 34904050
Diaphragmatic disorder 36.87 20.79 21 39155 1254 34916501
Asthma-chronic obstructive pulmonary disease overlap syndrome 36.69 20.79 21 39155 1266 34916489
Dermatitis atopic 36.36 20.79 37 39139 5310 34912445
Sinus disorder 35.92 20.79 42 39134 7043 34910712
Gastroenteritis viral 35.73 20.79 42 39134 7082 34910673
Nausea 35.69 20.79 229 38947 339679 34578076
Cardio-respiratory arrest 35.62 20.79 9 39167 55264 34862491
Claustrophobia 35.28 20.79 13 39163 277 34917478
Serum sickness 35.15 20.79 24 39152 1976 34915779
Blood immunoglobulin E decreased 35.14 20.79 9 39167 51 34917704
Blood pressure diastolic decreased 35.05 20.79 47 39129 9047 34908708
Lung hyperinflation 34.88 20.79 18 39158 882 34916873
Increased upper airway secretion 34.88 20.79 23 39153 1787 34915968
Polyp 34.17 20.79 31 39145 3861 34913894
Anaphylactoid reaction 34.14 20.79 25 39151 2300 34915455
Hypereosinophilic syndrome 33.80 20.79 12 39164 229 34917526
Nasal disorder 33.56 20.79 23 39153 1905 34915850
Viral infection 33.41 20.79 66 39110 17557 34900198
Anosmia 33.28 20.79 31 39145 3993 34913762
Throat clearing 32.98 20.79 13 39163 335 34917420
Coronary artery disease 32.84 20.79 7 39169 48298 34869457
Feeling abnormal 32.67 20.79 149 39027 63086 34854669
Dyspnoea at rest 32.65 20.79 30 39146 3798 34913957
Eye pruritus 32.44 20.79 41 39135 7448 34910307
Chronic kidney disease 32.42 20.79 4 39172 41206 34876549
Injection site swelling 31.97 20.79 51 39125 11476 34906279
Blood immunoglobulin E abnormal 31.96 20.79 7 39169 17 34917738
Blood bilirubin increased 31.96 20.79 3 39173 38293 34879462
International normalised ratio increased 31.89 20.79 7 39169 47320 34870435
Body mass index increased 31.88 20.79 18 39158 1057 34916698
Allergy to chemicals 31.52 20.79 9 39167 81 34917674
Sputum increased 31.49 20.79 24 39152 2346 34915409
Respiratory tract irritation 30.74 20.79 11 39165 215 34917540
Maternal exposure during breast feeding 30.72 20.79 20 39156 1521 34916234
Hyposmia 30.69 20.79 11 39165 216 34917539
Upper-airway cough syndrome 30.57 20.79 28 39148 3530 34914225
Coagulation factor deficiency 30.39 20.79 10 39166 150 34917605
Seizure 30.36 20.79 44 39132 104813 34812942
Coma 30.29 20.79 7 39169 45671 34872084
Scratch 30.04 20.79 27 39149 3321 34914434
Status asthmaticus 29.95 20.79 12 39164 323 34917432
Nasal discomfort 29.72 20.79 20 39156 1608 34916147
Sputum retention 29.42 20.79 13 39163 449 34917306
Cardiac failure congestive 29.33 20.79 30 39146 83240 34834515
Bronchiolitis 29.27 20.79 26 39150 3150 34914605
Pleural effusion 29.15 20.79 29 39147 81517 34836238
Urticaria thermal 28.98 20.79 5 39171 0 34917755
Vital capacity decreased 28.13 20.79 12 39164 380 34917375
Injection site urticaria 27.57 20.79 21 39155 2051 34915704
Stomatitis 27.24 20.79 7 39169 42507 34875248
Lung disorder 27.02 20.79 93 39083 34603 34883152
Papule 26.98 20.79 28 39148 4111 34913644
Upper respiratory tract infection 26.97 20.79 90 39086 32969 34884786
Inappropriate schedule of product administration 26.60 20.79 139 39037 62157 34855598
Hyperglycaemia 26.28 20.79 6 39170 39474 34878281
Mast cell activation syndrome 26.03 20.79 10 39166 240 34917515
Lacrimation increased 25.57 20.79 39 39137 8443 34909312
Hepatic function abnormal 25.36 20.79 9 39167 44354 34873401
Pneumonia 25.28 20.79 557 38619 362070 34555685
Oropharyngeal discomfort 25.24 20.79 24 39152 3172 34914583
Endocarditis fibroplastica 25.04 20.79 5 39171 6 34917749
Death 25.00 20.79 306 38870 397743 34520012
Upper respiratory tract congestion 24.66 20.79 14 39162 831 34916924
Haematuria 24.12 20.79 13 39163 50053 34867702
Dysphonia 24.03 20.79 69 39107 23314 34894441
Needle issue 23.97 20.79 32 39144 6133 34911622
Hallucination 23.91 20.79 14 39162 51484 34866271
Aggression 23.87 20.79 7 39169 38957 34878798
Ligament sprain 23.77 20.79 24 39152 3413 34914342
Injection site bruising 23.57 20.79 38 39138 8625 34909130
Procedural pain 23.55 20.79 28 39148 4778 34912977
General physical health deterioration 23.45 20.79 70 39106 128199 34789556
Eosinophilic oesophagitis 23.37 20.79 10 39166 319 34917436
Skin reaction 23.24 20.79 29 39147 5201 34912554
Therapeutic response decreased 23.20 20.79 79 39097 29234 34888521
Animal scratch 23.20 20.79 9 39167 222 34917533
Rubber sensitivity 23.16 20.79 9 39167 223 34917532
Central obesity 22.98 20.79 12 39164 603 34917152
Injection related reaction 22.67 20.79 10 39166 344 34917411
Rosacea 22.60 20.79 15 39161 1178 34916577
Choking 22.59 20.79 28 39148 4987 34912768
Blood test abnormal 22.37 20.79 33 39143 6938 34910817
Myalgia 22.27 20.79 166 39010 83944 34833811
Coagulation factor V level abnormal 22.22 20.79 6 39170 43 34917712
Liver function test abnormal 22.18 20.79 4 39172 31070 34886685
Rib fracture 21.57 20.79 49 39127 14351 34903404
Crepitations 21.52 20.79 22 39154 3174 34914581
Respiratory failure 21.51 20.79 57 39119 108515 34809240
Vomiting 21.50 20.79 176 39000 247445 34670310
Mite allergy 21.49 20.79 12 39164 690 34917065
Haematochezia 21.11 20.79 13 39163 46521 34871234
Pneumonitis 20.91 20.79 6 39170 33872 34883883
Multiple allergies 20.82 20.79 21 39155 2982 34914773
Atrial fibrillation 20.82 20.79 69 39107 122324 34795431

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Forced expiratory volume decreased 2864.79 16.84 877 126922 6937 79609652
Urticaria 2641.95 16.84 2261 125538 182940 79433649
Wheezing 2369.35 16.84 1754 126045 114910 79501679
Cough 1602.77 16.84 2418 125381 364371 79252218
Sputum discoloured 1457.76 16.84 707 127092 21036 79595553
Obstructive airways disorder 1428.15 16.84 787 127012 30672 79585917
Productive cough 1204.85 16.84 1053 126746 87278 79529311
Anaphylactic reaction 1111.41 16.84 983 126816 82760 79533829
Middle insomnia 1024.55 16.84 505 127294 15564 79601025
Dyspnoea 967.59 16.84 3285 124514 853740 78762849
Nasopharyngitis 864.72 16.84 1497 126302 252384 79364205
Chest discomfort 823.25 16.84 1059 126740 136985 79479604
Nasal congestion 802.02 16.84 788 127011 75764 79540825
Blood pressure systolic increased 782.08 16.84 732 127067 66254 79550335
Influenza 769.21 16.84 992 126807 128614 79487975
Heart rate increased 746.32 16.84 943 126856 119781 79496808
Sensitivity to weather change 737.02 16.84 325 127474 7722 79608867
Acute kidney injury 722.33 16.84 25 127774 519379 79097210
Blood pressure increased 705.82 16.84 1236 126563 210124 79406465
No adverse event 701.77 16.84 536 127263 36656 79579933
Blood immunoglobulin E increased 669.10 16.84 277 127522 5605 79610984
Toxicity to various agents 621.00 16.84 11 127788 421529 79195060
Pruritus 619.84 16.84 1702 126097 392946 79223643
Oropharyngeal pain 580.87 16.84 793 127006 108560 79508029
Body temperature decreased 515.46 16.84 421 127378 31724 79584865
Respiratory tract congestion 515.09 16.84 348 127451 19606 79596983
Drug interaction 514.45 16.84 40 127759 415143 79201446
Malaise 512.39 16.84 1835 125964 488034 79128555
Hypoventilation 499.37 16.84 240 127559 6984 79609605
Seasonal allergy 464.26 16.84 303 127496 16103 79600486
Asthma 463.44 16.84 800 126999 134295 79482294
Bronchitis 456.49 16.84 780 127019 129864 79486725
Skin plaque 430.93 16.84 248 127551 10497 79606092
Nasal polyps 427.83 16.84 217 127582 7110 79609479
Rhinorrhoea 427.18 16.84 567 127232 75507 79541082
Neutropenia 421.46 16.84 8 127791 287702 79328887
Respiratory rate increased 391.40 16.84 304 127495 21296 79595293
Asthmatic crisis 384.09 16.84 138 127661 1868 79614721
Hypersensitivity 347.18 16.84 1065 126734 261174 79355415
Forced vital capacity decreased 337.84 16.84 121 127678 1622 79614967
Anaemia 336.87 16.84 146 127653 444869 79171720
Perfume sensitivity 336.24 16.84 102 127697 777 79615812
Secretion discharge 331.54 16.84 238 127561 14784 79601805
Weight decreased 330.88 16.84 1283 126516 353915 79262674
Angioedema 329.72 16.84 501 127298 75534 79541055
Bronchopulmonary aspergillosis allergic 314.17 16.84 134 127665 2927 79613662
Infusion related reaction 309.67 16.84 14 127785 230223 79386366
Thrombocytopenia 305.82 16.84 34 127765 265225 79351364
Throat tightness 300.83 16.84 292 127507 27615 79588974
Breath sounds abnormal 281.01 16.84 221 127578 15763 79600826
Illness 277.06 16.84 357 127442 46154 79570435
Lower respiratory tract infection 272.04 16.84 624 127175 128596 79487993
Pulmonary function test decreased 271.35 16.84 163 127636 7474 79609115
Stress 268.29 16.84 468 127331 79144 79537445
Rales 265.38 16.84 235 127564 19766 79596823
Upper-airway cough syndrome 262.04 16.84 187 127612 11506 79605083
Hyponatraemia 260.11 16.84 5 127794 177843 79438746
Hypotension 255.77 16.84 199 127600 440118 79176471
Respiratory disorder 252.74 16.84 335 127464 44521 79572068
Pancytopenia 249.44 16.84 3 127796 165742 79450847
Drug abuse 244.60 16.84 3 127796 162688 79453901
Diarrhoea 244.21 16.84 670 127129 879819 78736770
Confusional state 244.19 16.84 102 127697 317895 79298694
Peak expiratory flow rate decreased 238.93 16.84 74 127725 609 79615980
Allergy to animal 238.46 16.84 89 127710 1350 79615239
Smoke sensitivity 237.85 16.84 72 127727 544 79616045
Sinusitis 235.61 16.84 769 127030 194732 79421857
Sneezing 235.10 16.84 218 127581 19465 79597124
Eosinophilic granulomatosis with polyangiitis 233.13 16.84 115 127684 3545 79613044
Dust allergy 232.81 16.84 89 127710 1447 79615142
Platelet count decreased 231.96 16.84 22 127777 194642 79421947
Inappropriate schedule of product administration 224.67 16.84 592 127207 133036 79483553
Dyspnoea exertional 223.89 16.84 456 127343 86617 79529972
Bronchospasm 223.83 16.84 236 127563 24623 79591966
Respiratory tract infection 221.26 16.84 328 127471 48361 79568228
Humidity intolerance 221.04 16.84 62 127737 345 79616244
Scratch 213.76 16.84 145 127654 8218 79608371
Synovitis 209.99 16.84 7 127792 150727 79465862
White blood cell count decreased 207.48 16.84 28 127771 188260 79428329
Dehydration 206.56 16.84 70 127729 248117 79368472
Sinus congestion 204.76 16.84 203 127596 19693 79596896
Lower respiratory tract congestion 200.72 16.84 107 127692 3890 79612699
Erythema 197.40 16.84 794 127005 222496 79394093
Disease progression 197.12 16.84 30 127769 184332 79432257
Pneumonia 195.08 16.84 1759 126040 658487 78958102
Drug intolerance 194.38 16.84 90 127709 264029 79352560
Food allergy 191.00 16.84 150 127649 10674 79605915
Condition aggravated 184.99 16.84 325 127474 500799 79115790
Hypokalaemia 183.55 16.84 12 127787 144028 79472561
Temperature intolerance 178.86 16.84 138 127661 9567 79607022
Dysphonia 178.29 16.84 324 127475 56548 79560041
Full blood count abnormal 177.24 16.84 268 127531 40206 79576383
Overdose 175.51 16.84 40 127759 184166 79432423
Throat irritation 174.88 16.84 268 127531 40678 79575911
Multiple organ dysfunction syndrome 173.35 16.84 4 127795 120242 79496347
Death 172.94 16.84 410 127389 566104 79050485
Pulmonary function test abnormal 169.77 16.84 97 127702 4047 79612542
Vital capacity decreased 168.38 16.84 74 127725 1742 79614847
Constipation 167.92 16.84 125 127674 282925 79333664
Headache 167.35 16.84 1690 126109 652082 78964507
Influenza like illness 163.95 16.84 358 127441 71349 79545240
Weight increased 163.48 16.84 876 126923 276510 79340079
Alanine aminotransferase increased 161.64 16.84 32 127767 162538 79454051
Hepatic enzyme increased 159.93 16.84 47 127752 182563 79434026
Swelling face 158.82 16.84 352 127447 70860 79545729
Sepsis 158.52 16.84 120 127679 269308 79347281
Feeling abnormal 158.51 16.84 588 127211 158611 79457978
Injection site pain 157.45 16.84 512 127287 129326 79487263
Nasal discharge discolouration 156.97 16.84 78 127721 2443 79614146
Hyperkalaemia 156.94 16.84 6 127793 114392 79502197
Renal failure 154.92 16.84 64 127735 200904 79415685
Aspartate aminotransferase increased 154.19 16.84 20 127779 138621 79477968
Gastrointestinal haemorrhage 153.48 16.84 26 127773 147693 79468896
Hand deformity 151.60 16.84 3 127796 103916 79512673
Septic shock 148.61 16.84 13 127786 122788 79493801
Stomatitis 147.77 16.84 28 127771 146729 79469860
Rhabdomyolysis 146.50 16.84 4 127795 103127 79513462
Viral infection 146.32 16.84 254 127545 42762 79573827
Eosinophil count increased 146.23 16.84 158 127641 16947 79599642
Aphonia 144.49 16.84 125 127674 10187 79606402
Total lung capacity decreased 143.72 16.84 77 127722 2828 79613761
Eye pruritus 143.54 16.84 171 127628 20399 79596190
Migraine 143.31 16.84 384 127415 87109 79529480
Leukopenia 141.91 16.84 12 127787 116501 79500088
Rhinitis allergic 140.96 16.84 133 127666 12136 79604453
Nasal oedema 139.90 16.84 64 127735 1660 79614929
Bronchial secretion retention 139.12 16.84 85 127714 4019 79612570
Bronchiectasis 136.69 16.84 174 127625 22212 79594377
Incorrect dose administered 136.44 16.84 347 127452 76283 79540306
Sinus pain 135.88 16.84 81 127718 3661 79612928
Cardiac arrest 133.94 16.84 54 127745 172042 79444547
Rubber sensitivity 132.80 16.84 62 127737 1687 79614902
Bradycardia 129.99 16.84 29 127770 135528 79481061
Urticaria thermal 129.90 16.84 42 127757 403 79616186
Exposure to allergen 128.00 16.84 39 127760 302 79616287
Arthropathy 127.71 16.84 62 127737 177049 79439540
Renal impairment 126.94 16.84 47 127752 157736 79458853
Lip swelling 126.85 16.84 232 127567 40679 79575910
Rheumatoid arthritis 126.28 16.84 90 127709 208380 79408209
Reversible airways obstruction 125.73 16.84 64 127735 2112 79614477
Cardiac failure congestive 124.04 16.84 37 127762 142365 79474224
Treatment failure 123.97 16.84 59 127740 170427 79446162
Animal scratch 123.66 16.84 56 127743 1418 79615171
Off label use 119.63 16.84 908 126891 906307 78710282
Pharyngeal swelling 119.30 16.84 99 127700 7620 79608969
Neutrophil count decreased 119.18 16.84 8 127791 93951 79522638
Decreased appetite 119.16 16.84 230 127569 342188 79274401
Eczema 118.47 16.84 225 127574 40593 79575996
Eye swelling 118.35 16.84 177 127622 26291 79590298
Nausea 117.92 16.84 976 126823 956220 78660369
Joint swelling 117.80 16.84 175 127624 288471 79328118
Increased bronchial secretion 115.58 16.84 70 127729 3257 79613332
Interstitial lung disease 114.38 16.84 21 127778 112579 79504010
Neuropathy peripheral 113.83 16.84 42 127757 141263 79475326
Respiratory failure 108.39 16.84 79 127720 180832 79435757
Forced expiratory flow decreased 108.25 16.84 33 127766 256 79616333
Electrocardiogram QT prolonged 108.19 16.84 10 127789 90376 79526213
International normalised ratio increased 108.08 16.84 7 127792 84714 79531875
Atrial fibrillation 107.81 16.84 95 127704 197791 79418798
Paranasal sinus discomfort 106.18 16.84 74 127725 4382 79612207
Lung disorder 106.16 16.84 327 127472 80230 79536359
Urinary tract discomfort 105.40 16.84 41 127758 700 79615889
Systemic lupus erythematosus 104.56 16.84 32 127767 121117 79495472
Cardio-respiratory arrest 104.46 16.84 23 127776 108487 79508102
Increased viscosity of bronchial secretion 100.62 16.84 37 127762 537 79616052
Ascites 100.21 16.84 5 127794 75557 79541032
Lacrimation increased 100.05 16.84 150 127649 22327 79594262
Glossodynia 99.28 16.84 22 127777 103315 79513274
Rhinitis 98.26 16.84 120 127679 14687 79601902
Psoriatic arthropathy 97.88 16.84 7 127792 77992 79538597
Blood creatinine increased 96.46 16.84 65 127734 154992 79461597
Spirometry abnormal 95.18 16.84 41 127758 918 79615671
Ear pruritus 94.94 16.84 67 127732 4048 79612541
Myalgia 94.53 16.84 564 127235 185077 79431512
Depressed level of consciousness 94.03 16.84 20 127779 96632 79519957
Multiple allergies 93.61 16.84 99 127700 10361 79606228
Alveolar osteitis 93.41 16.84 39 127760 806 79615783
Blood bilirubin increased 92.49 16.84 3 127796 66229 79550360
Lactic acidosis 92.22 16.84 5 127794 70354 79546235
Rhonchi 91.47 16.84 65 127734 3971 79612618
Frustration tolerance decreased 91.34 16.84 84 127715 7418 79609171
Swollen tongue 91.06 16.84 207 127592 42363 79574226
Oropharyngeal discomfort 90.69 16.84 82 127717 7084 79609505
Anaphylactic shock 90.68 16.84 187 127612 35809 79580780
Pericarditis 89.12 16.84 28 127771 104208 79512381
Ear pain 89.05 16.84 176 127623 32693 79583896
Drug-induced liver injury 88.89 16.84 4 127795 66113 79550476
Haemoglobin decreased 88.34 16.84 137 127662 221982 79394607
Delirium 87.65 16.84 15 127784 84612 79531977
Product use issue 86.75 16.84 126 127673 209696 79406893
Sinus disorder 86.18 16.84 140 127659 22324 79594265
Feeling hot 85.81 16.84 250 127549 59484 79557105
Vomiting 84.94 16.84 672 127127 665156 78951433
Mental status changes 84.05 16.84 6 127793 66953 79549636
Insomnia 84.03 16.84 676 127123 244494 79372095
Mechanical urticaria 83.29 16.84 30 127769 409 79616180
Ear congestion 82.78 16.84 54 127745 2865 79613724
Helicobacter infection 82.66 16.84 8 127791 69696 79546893
Hepatic failure 81.34 16.84 4 127795 61208 79555381
Coma 80.91 16.84 30 127769 100619 79515970
Papule 80.73 16.84 78 127721 7329 79609260
FEV1/FVC ratio decreased 80.58 16.84 25 127774 207 79616382
Dyspnoea at rest 79.79 16.84 77 127722 7225 79609364
Suicide attempt 78.97 16.84 18 127781 82914 79533675
Blood pressure decreased 77.84 16.84 341 127458 99125 79517464
Melaena 77.76 16.84 5 127794 60885 79555704
Therapeutic product effect decreased 77.43 16.84 89 127710 163774 79452815
C-reactive protein increased 76.42 16.84 57 127742 128970 79487619
Respiratory tract inflammation 76.07 16.84 34 127765 834 79615755
Hallucination 75.16 16.84 22 127777 85723 79530866
Liver function test abnormal 74.90 16.84 8 127791 64467 79552122
Product availability issue 74.65 16.84 57 127742 3890 79612699
Serum sickness 73.90 16.84 55 127744 3611 79612978
Hepatic function abnormal 73.46 16.84 14 127785 73093 79543496
Tunnel vision 72.98 16.84 40 127759 1538 79615051
Crepitations 72.74 16.84 85 127714 9932 79606657
Sputum culture positive 72.38 16.84 55 127744 3726 79612863
Folliculitis 72.38 16.84 4 127795 55376 79561213
Cholestasis 70.56 16.84 3 127796 52106 79564483
Chronic kidney disease 70.13 16.84 11 127788 66143 79550446
Hypoglycaemia 69.59 16.84 38 127761 101556 79515033
Total lung capacity increased 68.83 16.84 44 127755 2254 79614335
Restrictive pulmonary disease 68.72 16.84 46 127753 2549 79614040
Pulmonary congestion 68.51 16.84 141 127658 26959 79589630
Throat clearing 67.78 16.84 46 127753 2608 79613981
Ligament sprain 67.41 16.84 95 127704 13369 79603220
Paraesthesia oral 67.17 16.84 119 127680 20352 79596237
Hepatitis 67.13 16.84 6 127793 55721 79560868
Cognitive disorder 66.94 16.84 15 127784 69911 79546678
Mastocytosis 66.66 16.84 27 127772 515 79616074
Pulmonary mass 66.38 16.84 145 127654 28889 79587700
Pleural effusion 66.38 16.84 81 127718 145181 79471408
Concomitant disease aggravated 66.06 16.84 93 127706 13074 79603515
Blood iron decreased 65.86 16.84 101 127698 15333 79601256
Abdominal discomfort 65.28 16.84 196 127603 250531 79366058
Coronary artery disease 64.81 16.84 13 127786 65461 79551128
Blood immunoglobulin E decreased 64.81 16.84 18 127781 96 79616493
Unresponsive to stimuli 64.60 16.84 7 127792 55781 79560808
Ear infection 64.49 16.84 159 127640 34273 79582316
Blood alkaline phosphatase increased 64.38 16.84 12 127787 63652 79552937
Cold urticaria 64.35 16.84 18 127781 99 79616490
Hypocalcaemia 64.05 16.84 4 127795 49920 79566669
General physical health deterioration 63.48 16.84 227 127572 275011 79341578
Nervousness 63.32 16.84 155 127644 33260 79583329
Chronic obstructive pulmonary disease 63.19 16.84 288 127511 85131 79531458
Choking 63.00 16.84 87 127712 12014 79604575
Impaired healing 62.68 16.84 31 127768 87624 79528965
Breast cancer 62.22 16.84 155 127644 33626 79582963
Muscle injury 61.97 16.84 4 127795 48557 79568032
Adverse event 61.64 16.84 11 127788 60203 79556386
Plasma cell myeloma 60.87 16.84 7 127792 53252 79563337
Bladder pain 60.87 16.84 41 127758 2296 79614293
Sensation of foreign body 59.90 16.84 58 127741 5464 79611125
Seizure 59.57 16.84 134 127665 188700 79427889
Mast cell activation syndrome 59.28 16.84 27 127772 693 79615896
Anxiety 59.25 16.84 634 127165 247878 79368711
Intentional product misuse 59.03 16.84 40 127759 95125 79521464
Colitis 58.66 16.84 22 127777 73285 79543304
Limb injury 58.13 16.84 139 127660 29389 79587200
Drug reaction with eosinophilia and systemic symptoms 57.20 16.84 16 127783 64228 79552361
Hypoaesthesia oral 56.88 16.84 90 127709 14034 79602555
Agranulocytosis 56.61 16.84 4 127795 45026 79571563
Pharyngeal oedema 56.52 16.84 97 127702 16175 79600414
Burning sensation 56.16 16.84 214 127585 58418 79558171
Orthostatic hypotension 55.91 16.84 11 127788 56153 79560436
Liver disorder 55.86 16.84 23 127776 72394 79544195
Injection site discomfort 55.55 16.84 54 127745 5112 79611477
Cardiogenic shock 54.86 16.84 3 127796 41911 79574678
Lung diffusion test decreased 54.57 16.84 31 127768 1279 79615310
Wound secretion 52.61 16.84 57 127742 6131 79610458
Gamma-glutamyltransferase increased 51.79 16.84 12 127787 54668 79561921
Lung hyperinflation 51.76 16.84 34 127765 1825 79614764
Hyposmia 51.61 16.84 25 127774 740 79615849
Hypokinesia 51.55 16.84 102 127697 18958 79597631
Nasal disorder 51.42 16.84 45 127754 3724 79612865
Asthma-chronic obstructive pulmonary disease overlap syndrome 51.21 16.84 42 127757 3179 79613410
Food intolerance 50.61 16.84 45 127754 3803 79612786
Haematochezia 50.26 16.84 40 127759 87605 79528984
Bronchial obstruction 50.22 16.84 39 127760 2729 79613860
Medication error 49.50 16.84 24 127775 68618 79547971
Gastrooesophageal reflux disease 49.40 16.84 311 127488 103935 79512654
Increased upper airway secretion 49.36 16.84 46 127753 4131 79612458
Hospitalisation 49.20 16.84 47 127752 94189 79522400
Urinary retention 48.78 16.84 15 127784 56615 79559974
Periorbital swelling 48.66 16.84 39 127760 2857 79613732
Treatment noncompliance 48.47 16.84 12 127787 52256 79564333
Cystic fibrosis 48.32 16.84 44 127755 3836 79612753
Ear discomfort 48.16 16.84 64 127735 8519 79608070
Injection site bruising 48.13 16.84 160 127639 40842 79575747
Blood urea increased 47.64 16.84 10 127789 48780 79567809
Acute respiratory distress syndrome 47.46 16.84 7 127792 44060 79572529
Claustrophobia 47.44 16.84 28 127771 1242 79615347
Nasal mucosal disorder 46.98 16.84 19 127780 361 79616228
Acute myocardial infarction 46.95 16.84 33 127766 77003 79539586
Ventricular tachycardia 46.72 16.84 6 127793 41929 79574660
Hypercalcaemia 46.67 16.84 4 127795 38426 79578163
Blood creatine phosphokinase increased 46.31 16.84 24 127775 66066 79550523
Fatigue 46.29 16.84 1874 125925 927853 78688736
Rash maculo-papular 46.28 16.84 16 127783 56062 79560527
Therapeutic response decreased 46.20 16.84 221 127578 66632 79549957
Anaphylactoid reaction 46.19 16.84 50 127749 5372 79611217
Rectal haemorrhage 46.09 16.84 33 127766 76267 79540322
Hyperventilation 46.03 16.84 60 127739 7839 79608750
Prescribed overdose 45.85 16.84 4 127795 37879 79578710
Upper respiratory tract infection 45.73 16.84 276 127523 90892 79525697
Quality of life decreased 45.60 16.84 69 127730 10351 79606238
Cardiac failure 45.55 16.84 114 127685 154728 79461861
Wrist fracture 45.32 16.84 74 127725 11847 79604742
Decompression sickness 45.10 16.84 13 127786 81 79616508
Pulmonary pain 44.84 16.84 45 127754 4428 79612161
Pancreatitis acute 44.82 16.84 12 127787 49592 79566997
Irritable bowel syndrome 44.52 16.84 22 127777 62219 79554370
Polymyalgia rheumatica 44.30 16.84 45 127754 4492 79612097
Osteonecrosis of jaw 44.02 16.84 8 127791 43218 79573371
Accident 43.75 16.84 62 127737 8769 79607820
Hypervolaemia 43.26 16.84 8 127791 42682 79573907
Haematemesis 42.98 16.84 15 127784 52249 79564340
Acute respiratory failure 42.65 16.84 21 127778 59520 79557069
Body temperature increased 42.43 16.84 162 127637 44258 79572331
Lethargy 41.91 16.84 41 127758 81251 79535338
Cerebral haemorrhage 41.83 16.84 20 127779 57653 79558936
Pneumonia aspiration 41.73 16.84 28 127771 66939 79549650
Mouth swelling 41.71 16.84 50 127749 6001 79610588
Otorrhoea 41.63 16.84 29 127770 1716 79614873
Dizziness 41.58 16.84 1121 126678 525320 79091269
Psychotic disorder 41.44 16.84 8 127791 41394 79575195
Nasal inflammation 40.89 16.84 21 127778 706 79615883
Hallucination, visual 40.88 16.84 3 127796 32726 79583863
Wound complication 40.72 16.84 45 127754 4948 79611641
Deep vein thrombosis 40.46 16.84 83 127716 120836 79495753
Skin lesion 40.29 16.84 153 127646 41691 79574898
Body temperature abnormal 39.94 16.84 32 127767 2343 79614246
Musculoskeletal stiffness 39.88 16.84 145 127654 174863 79441726
Nasal pruritus 39.83 16.84 19 127780 543 79616046
Jaundice 39.47 16.84 18 127781 53331 79563258
Neonatal hypoacusis 39.42 16.84 9 127790 17 79616572
Cryopyrin associated periodic syndrome 39.41 16.84 17 127782 382 79616207
Status asthmaticus 39.16 16.84 23 127776 1011 79615578
Cytomegalovirus infection 39.14 16.84 10 127789 42634 79573955
Tubulointerstitial nephritis 39.10 16.84 7 127792 38228 79578361
Respiration abnormal 39.06 16.84 55 127744 7733 79608856
Skin ulcer 38.94 16.84 19 127780 54131 79562458
Respiratory rate decreased 38.92 16.84 45 127754 5198 79611391
Myopathy 38.55 16.84 95 127704 20468 79596121
Auditory neuropathy spectrum disorder 38.44 16.84 9 127790 20 79616569
Circulatory collapse 38.30 16.84 7 127792 37661 79578928
Head deformity 38.15 16.84 10 127789 41 79616548
Disorientation 38.11 16.84 27 127772 62749 79553840
Sputum retention 37.90 16.84 23 127776 1074 79615515
Cerebral infarction 37.75 16.84 13 127786 45663 79570926
Lymphopenia 37.60 16.84 3 127796 30554 79586035
Pulmonary hypertension 37.52 16.84 15 127784 48065 79568524
Myelodysplastic syndrome 37.22 16.84 3 127796 30298 79586291
Blood immunoglobulin E abnormal 37.02 16.84 9 127790 25 79616564
Heart rate abnormal 36.85 16.84 47 127752 6010 79610579
Needle issue 36.64 16.84 71 127728 12997 79603592
Injection related reaction 36.51 16.84 22 127777 1014 79615575
Haematocrit decreased 36.40 16.84 27 127772 61285 79555304
Stevens-Johnson syndrome 36.30 16.84 9 127790 39157 79577432
Coagulopathy 35.95 16.84 7 127792 35999 79580590
Gastroenteritis viral 35.72 16.84 104 127695 24727 79591862
Urticaria chronic 35.53 16.84 18 127781 588 79616001
Mite allergy 35.48 16.84 23 127776 1207 79615382
Generalised tonic-clonic seizure 35.43 16.84 13 127786 43897 79572692
Pneumocystis jirovecii pneumonia 35.39 16.84 5 127794 32503 79584086
Altered state of consciousness 35.31 16.84 13 127786 43809 79572780
Intentional self-injury 35.26 16.84 5 127794 32414 79584175
Allergy test positive 35.18 16.84 19 127780 709 79615880
Conjunctivitis allergic 35.11 16.84 26 127773 1694 79614895
Clostridium difficile colitis 35.06 16.84 5 127794 32278 79584311
Psoriasis 34.88 16.84 56 127743 89531 79527058
Acne 34.53 16.84 109 127690 27081 79589508
Laboratory test abnormal 33.84 16.84 3 127796 28045 79588544
Peritonitis 33.82 16.84 3 127796 28033 79588556
Pulmonary embolism 33.58 16.84 151 127648 171503 79445086
Hip arthroplasty 33.56 16.84 8 127791 35748 79580841
Device related infection 33.54 16.84 7 127792 34287 79582302
Dyskinesia 33.29 16.84 15 127784 44758 79571831
Urticarial vasculitis 33.23 16.84 17 127782 567 79616022
Bronchial wall thickening 32.99 16.84 30 127769 2611 79613978
Functional residual capacity decreased 32.87 16.84 10 127789 77 79616512
Intentional product use issue 32.73 16.84 129 127670 151983 79464606
Aphasia 32.70 16.84 17 127782 46715 79569874
Pancreatitis 32.64 16.84 37 127762 68538 79548051
Forced expiratory volume abnormal 32.59 16.84 11 127788 122 79616467
Movement disorder 32.55 16.84 107 127692 27152 79589437
Myocardial infarction 32.52 16.84 168 127631 183961 79432628
Factor V Leiden mutation 32.46 16.84 12 127787 177 79616412
Expiratory reserve volume decreased 32.21 16.84 10 127789 83 79616506
Respiratory tract irritation 32.14 16.84 17 127782 608 79615981
Therapy non-responder 32.04 16.84 62 127737 92243 79524346
Full blood count decreased 32 16.84 3 127796 26816 79589773
Sedation 31.93 16.84 22 127777 51873 79564716
Fluid retention 31.80 16.84 39 127760 69770 79546819
Allergy to chemicals 31.42 16.84 29 127770 2573 79614016
Adverse drug reaction 31.41 16.84 36 127763 66356 79550233
Functional residual capacity increased 31.40 16.84 10 127789 91 79616498
Feeling cold 30.99 16.84 109 127690 28620 79587969
Injection site scab 30.89 16.84 14 127785 355 79616234
Urinary tract infection 30.87 16.84 286 127513 274226 79342363
Cystic fibrosis pancreatic 30.83 16.84 9 127790 59 79616530
Chronic spontaneous urticaria 30.75 16.84 21 127778 1203 79615386
Symptom recurrence 30.31 16.84 27 127772 2287 79614302
Ventricular fibrillation 30.25 16.84 7 127792 31919 79584670
Chest X-ray abnormal 30.06 16.84 49 127750 7834 79608755
Knee arthroplasty 29.87 16.84 16 127783 43232 79573357
Dermoid cyst 29.86 16.84 13 127786 299 79616290
Nocturnal dyspnoea 29.70 16.84 23 127776 1603 79614986
Upper limb fracture 29.54 16.84 79 127720 17888 79598701
Abnormal behaviour 29.02 16.84 11 127788 36410 79580179
Frequent bowel movements 28.95 16.84 6 127793 29533 79587056
Pain in extremity 28.94 16.84 777 127022 363761 79252828
Femur fracture 28.66 16.84 13 127786 38639 79577950
Bronchial disorder 28.62 16.84 27 127772 2462 79614127
Injection site hypoaesthesia 28.55 16.84 15 127784 529 79616060
Pharyngeal paraesthesia 28.43 16.84 28 127771 2693 79613896
Ligament rupture 28.39 16.84 31 127768 3363 79613226
Body mass index increased 28.24 16.84 24 127775 1909 79614680
Diaphragmatic disorder 28.20 16.84 23 127776 1727 79614862
Blood calcium decreased 28.18 16.84 8 127791 31811 79584778
Agitation 28.10 16.84 75 127724 99640 79516949
Hypoacusis 28.01 16.84 109 127690 30041 79586548
Procedural pain 27.91 16.84 91 127708 22993 79593596
Drug eruption 27.87 16.84 18 127781 43917 79572672
Administration site erythema 27.70 16.84 13 127786 358 79616231
Upper respiratory tract congestion 27.60 16.84 27 127772 2576 79614013
Exercise tolerance decreased 27.55 16.84 51 127748 9020 79607569
Ear swelling 27.48 16.84 22 127777 1609 79614980
Chronic sinusitis 27.47 16.84 63 127736 12963 79603626
Respiratory arrest 27.45 16.84 31 127768 57519 79559070
Shock 27.41 16.84 18 127781 43530 79573059
Forced expiratory volume increased 27.21 16.84 8 127791 54 79616535
Pigmentation disorder 27.18 16.84 39 127760 5579 79611010
Oral pruritus 27.10 16.84 26 127773 2422 79614167
Injection site erythema 26.95 16.84 216 127583 77981 79538608
Electrolyte imbalance 26.92 16.84 8 127791 30873 79585716
Peak expiratory flow rate abnormal 26.90 16.84 9 127790 97 79616492
Ejection fraction decreased 26.64 16.84 11 127788 34566 79582023
Joint range of motion decreased 26.61 16.84 10 127789 33272 79583317
Pain in jaw 26.53 16.84 21 127778 46130 79570459
Sinus tachycardia 26.46 16.84 13 127786 36895 79579694
Hyperlipidaemia 26.20 16.84 5 127794 26088 79590501
Depression 26.06 16.84 222 127577 216568 79400021
Glomerular filtration rate decreased 25.90 16.84 3 127796 22699 79593890
Gastric ulcer 25.77 16.84 11 127788 33894 79582695
Injection site swelling 25.77 16.84 146 127653 46986 79569603
Hypereosinophilic syndrome 25.64 16.84 14 127785 534 79616055
Malnutrition 25.61 16.84 3 127796 22499 79594090
Reaction to azo-dyes 25.43 16.84 6 127793 14 79616575
Lymphocyte count decreased 25.37 16.84 23 127776 47266 79569323
Toxic skin eruption 25.30 16.84 3 127796 22290 79594299
Red blood cell count decreased 25.29 16.84 33 127766 57480 79559109
Sputum increased 25.27 16.84 34 127765 4579 79612010
Vascular access site thrombosis 25.26 16.84 7 127792 37 79616552
Fear of disease 25.19 16.84 19 127780 1273 79615316
Lung opacity 25.15 16.84 36 127763 5138 79611451
Drug ineffective for unapproved indication 25.10 16.84 27 127772 51211 79565378
Poisoning 25.05 16.84 5 127794 25267 79591322
Blood lactate dehydrogenase increased 24.91 16.84 16 127783 39154 79577435
Laryngitis 24.85 16.84 69 127730 15970 79600619
Injection site urticaria 24.84 16.84 60 127739 12766 79603823
Urosepsis 24.73 16.84 6 127793 26489 79590100
Wound 24.69 16.84 99 127700 116080 79500509
Tachycardia 24.66 16.84 175 127624 177593 79438996
Infection 24.58 16.84 258 127541 241454 79375135
Drug resistance 24.53 16.84 19 127780 42194 79574395
Osteomyelitis 24.45 16.84 11 127788 32854 79583735
Pulmonary oedema 24.40 16.84 67 127732 88187 79528402
Respiratory depression 24.37 16.84 7 127792 27623 79588966
Atrial flutter 24.32 16.84 3 127796 21622 79594967
Respiratory fume inhalation disorder 24.25 16.84 10 127789 200 79616389
Skin swelling 24.19 16.84 31 127768 3983 79612606
Sense of oppression 24.02 16.84 20 127779 1546 79615043
Drug hypersensitivity 23.96 16.84 638 127161 298278 79318311
Subarachnoid haemorrhage 23.92 16.84 5 127794 24460 79592129
Small intestinal obstruction 23.89 16.84 7 127792 27265 79589324
Flatulence 23.87 16.84 20 127779 42704 79573885
Injection site pruritus 23.80 16.84 132 127667 42151 79574438
Abdominal pain 23.62 16.84 461 127338 389108 79227481
Metastases to liver 23.50 16.84 8 127791 28306 79588283
Withdrawal syndrome 23.33 16.84 7 127792 26847 79589742
Choking sensation 23.27 16.84 30 127769 3876 79612713
Urinary incontinence 23.04 16.84 19 127780 40890 79575699
Coagulation factor deficiency 22.96 16.84 9 127790 157 79616432
Panic attack 22.86 16.84 88 127711 24128 79592461
Surgery 22.80 16.84 12 127787 32754 79583835
Atopy 22.72 16.84 12 127787 428 79616161
Right ventricular failure 22.57 16.84 5 127794 23492 79593097
Muscle tension dysphonia 22.55 16.84 9 127790 165 79616424
Blood test abnormal 22.49 16.84 71 127728 17639 79598950
Mycotic allergy 22.48 16.84 19 127780 1500 79615089
Unevaluable event 22.35 16.84 34 127765 55551 79561038
Mitral valve incompetence 22.14 16.84 9 127790 28556 79588033
Pericardial effusion 21.95 16.84 25 127774 46212 79570377
Metastases to bone 21.90 16.84 6 127793 24421 79592168
Muscle rigidity 21.78 16.84 3 127796 19879 79596710
Occupational exposure to dust 21.76 16.84 6 127793 31 79616558
Visual acuity reduced 21.71 16.84 10 127789 29459 79587130
Blood pressure diastolic decreased 21.68 16.84 101 127698 30115 79586474
Local reaction 21.68 16.84 13 127786 594 79615995
Bronchomalacia 21.59 16.84 10 127789 267 79616322
Hereditary angioedema 21.49 16.84 34 127765 5301 79611288
Blood potassium increased 21.46 16.84 10 127789 29265 79587324
Polyp 21.46 16.84 43 127756 8064 79608525
Sinus headache 21.33 16.84 33 127766 5047 79611542
Epistaxis 21.26 16.84 99 127700 111416 79505173
Sputum abnormal 21.18 16.84 17 127782 1248 79615341
Vaccination site pain 21.16 16.84 9 127790 195 79616394
Injection site eczema 21.04 16.84 7 127792 74 79616515
Skin reaction 20.94 16.84 65 127734 16003 79600586
Ataxia 20.91 16.84 7 127792 25032 79591557
Tryptase increased 20.80 16.84 13 127786 640 79615949
Abortion spontaneous 20.71 16.84 98 127701 29409 79587180
Asthma exercise induced 20.65 16.84 8 127791 135 79616454
Device dislocation 20.43 16.84 8 127791 25962 79590627
Ehlers-Danlos syndrome 20.28 16.84 8 127791 142 79616447
Sputum culture 20.28 16.84 9 127790 217 79616372
Laryngeal oedema 20.20 16.84 42 127757 8087 79608502
Chromaturia 20.14 16.84 8 127791 25738 79590851
Live birth 20.13 16.84 3 127796 18741 79597848
Eosinophilia 20.07 16.84 133 127666 45212 79571377
Endocarditis fibroplastica 20.04 16.84 5 127794 16 79616573
Joint injury 19.80 16.84 101 127698 31234 79585355
Cardiac infection 19.79 16.84 11 127788 435 79616154
Allergic sinusitis 19.73 16.84 14 127785 853 79615736
Gastrointestinal disorder 19.65 16.84 115 127684 122090 79494499
Hypothermia 19.63 16.84 6 127793 22740 79593849
Red blood cell sedimentation rate increased 19.55 16.84 27 127772 45915 79570674
Eye allergy 19.51 16.84 13 127786 715 79615874
Sarcoidosis 19.48 16.84 42 127757 8293 79608296
COVID-19 pneumonia 19.45 16.84 11 127788 28838 79587751
Dermatitis atopic 19.43 16.84 47 127752 10009 79606580
Ulcer 19.40 16.84 12 127787 29960 79586629
Upper airway obstruction 19.38 16.84 17 127782 1411 79615178
Sudden death 19.32 16.84 6 127793 22505 79594084
Metastases to lung 19.29 16.84 3 127796 18160 79598429
Therapy cessation 19.29 16.84 19 127780 37543 79579046
Blood sodium decreased 19.28 16.84 15 127784 33240 79583349
Head discomfort 19.21 16.84 59 127740 14443 79602146
Caffeine allergy 19.17 16.84 5 127794 20 79616569
Ileus 19.15 16.84 9 127790 26202 79590387
Ligament pain 19.14 16.84 9 127790 249 79616340
Escherichia infection 19.08 16.84 3 127796 18014 79598575
Croup infectious 19.06 16.84 13 127786 743 79615846
Leukocytosis 19.04 16.84 25 127774 43430 79573159
Bronchial irritation 19.00 16.84 6 127793 53 79616536
Physiotherapy chest 18.99 16.84 4 127795 4 79616585
Suicidal ideation 18.91 16.84 61 127738 76279 79540310
General physical condition abnormal 18.82 16.84 36 127763 6527 79610062
Skin laceration 18.76 16.84 94 127705 28868 79587721
Arthropod sting 18.62 16.84 16 127783 1292 79615297
Speech disorder 18.54 16.84 150 127649 54295 79562294
Suffocation feeling 18.53 16.84 18 127781 1702 79614887
Colitis ulcerative 18.52 16.84 17 127782 34725 79581864
Coagulation factor V level abnormal 18.43 16.84 6 127793 59 79616530
Proteinuria 18.42 16.84 15 127784 32487 79584102
Hydronephrosis 18.28 16.84 3 127796 17451 79599138
Myocardial ischaemia 18.28 16.84 9 127790 25510 79591079
Injection site reaction 18.15 16.84 150 127649 54635 79561954
Nasal discomfort 18.15 16.84 32 127767 5451 79611138
Bruxism 18.10 16.84 27 127772 3999 79612590
Polyneuropathy 18.10 16.84 8 127791 24143 79592446
Oxygen saturation decreased 18.07 16.84 299 127500 128748 79487841
Pleural rub 17.99 16.84 6 127793 64 79616525
Brain oedema 17.96 16.84 9 127790 25254 79591335
Paraesthesia 17.96 16.84 389 127410 175934 79440655
Musculoskeletal disorder 17.90 16.84 6 127793 21442 79595147
Device malfunction 17.90 16.84 6 127793 21442 79595147
Dystonia 17.84 16.84 6 127793 21393 79595196
Extrapyramidal disorder 17.82 16.84 7 127792 22672 79593917
Disability 17.80 16.84 3 127796 17117 79599472
Swelling of eyelid 17.77 16.84 26 127773 3785 79612804
Vascular access site infection 17.76 16.84 7 127792 124 79616465
Haematuria 17.75 16.84 54 127745 68782 79547807
Allergy to metals 17.74 16.84 11 127788 534 79616055
Pneumonitis 17.74 16.84 45 127754 60815 79555774
Tooth disorder 17.69 16.84 10 127789 26223 79590366
Dermatitis contact 17.62 16.84 48 127751 10985 79605604
Arthralgia 17.60 16.84 1101 126698 570702 79045887
Dialysis 17.59 16.84 4 127795 18458 79598131
Pharyngitis streptococcal 17.50 16.84 47 127752 10667 79605922
Acute coronary syndrome 17.49 16.84 6 127793 21127 79595462
Overweight 17.48 16.84 27 127772 4123 79612466
Product prescribing error 17.45 16.84 28 127771 44785 79571804
COVID-19 17.39 16.84 165 127634 157509 79459080
Tongue pruritus 17.29 16.84 11 127788 559 79616030
Lipohypertrophy 17.23 16.84 13 127786 871 79615718
Oropharyngeal spasm 17.23 16.84 10 127789 430 79616159
Red blood cell count increased 17.20 16.84 27 127772 4181 79612408
Urticaria pressure 17.10 16.84 5 127794 33 79616556
Skin necrosis 17.07 16.84 4 127795 18083 79598506
Iron deficiency anaemia 17.00 16.84 10 127789 25662 79590927
Paranoia 17.00 16.84 5 127794 19427 79597162
Urine output decreased 16.98 16.84 4 127795 18018 79598571
Breath sounds 16.93 16.84 7 127792 141 79616448
Flushing 16.91 16.84 216 127583 88052 79528537
Left ventricular dysfunction 16.90 16.84 5 127794 19356 79597233
Eosinophilic oesophagitis 16.87 16.84 11 127788 583 79616006

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R03DX05 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Other systemic drugs for obstructive airway diseases
MeSH PA D018926 Anti-Allergic Agents
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D019141 Respiratory System Agents
FDA MoA N0000175792 IgE-directed Antibody Interactions
FDA PE N0000175793 Decreased IgE Activity
FDA EPC N0000175794 Anti-IgE

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Asthma indication 195967001 DOID:2841
Chronic idiopathic urticaria indication 302162004
Seasonal allergic rhinitis indication 367498001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Ig epsilon chain C region Antibody ANTIBODY BINDING Kd 8.16 IUPHAR DRUG LABEL

External reference:

IDSource
D05251 KEGG_DRUG
4021399 VUID
N0000148817 NUI
4021399 VANDF
CHEMBL1201589 ChEMBL_ID
C401983 MESH_SUPPLEMENTAL_RECORD_UI
6890 IUPHAR_LIGAND_ID
DB00043 DRUGBANK_ID
302379 RXNORM
17379 MMSL
46992 MMSL
d04881 MMSL
000571 NDDF
406442003 SNOMEDCT_US
406443008 SNOMEDCT_US
D000069444 MESH_DESCRIPTOR_UI
C0966225 UMLSCUI
8039 INN_ID
2P471X1Z11 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
XOLAIR HUMAN PRESCRIPTION DRUG LABEL 1 50242-040 INJECTION, SOLUTION 202.50 mg SUBCUTANEOUS BLA 32 sections
XOLAIR HUMAN PRESCRIPTION DRUG LABEL 1 50242-040 INJECTION, SOLUTION 150 mg SUBCUTANEOUS BLA 32 sections
Xolair PFS HUMAN PRESCRIPTION DRUG LABEL 1 50242-214 INJECTION, SOLUTION 75 mg SUBCUTANEOUS BLA 32 sections
Xolair PFS HUMAN PRESCRIPTION DRUG LABEL 1 50242-214 INJECTION, SOLUTION 75 mg SUBCUTANEOUS BLA 32 sections
Xolair PFS HUMAN PRESCRIPTION DRUG LABEL 1 50242-215 INJECTION, SOLUTION 150 mg SUBCUTANEOUS BLA 32 sections
Xolair PFS HUMAN PRESCRIPTION DRUG LABEL 1 50242-215 INJECTION, SOLUTION 150 mg SUBCUTANEOUS BLA 32 sections
Xolair HUMAN PRESCRIPTION DRUG LABEL 1 50242-227 INJECTION, SOLUTION 300 mg SUBCUTANEOUS BLA 32 sections