retinol acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
retinol derivatives 2372 127-47-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • retinyl acetate
  • QLT091001
  • retinol acetate
  • Vitamin A acetate
  • Molecular weight: 328.50
  • Formula: C22H32O2
  • CLOGP: 7.35
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 26.30
  • ALOGS: -5.14
  • ROTB: 7

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 2026.52 10.35 4403 483393 179323 62821903
Systemic lupus erythematosus 1923.53 10.35 4662 483134 204256 62796970
Glossodynia 1696.80 10.35 4039 483757 174837 62826389
Hand deformity 1399.19 10.35 3495 484301 155962 62845264
Arthropathy 1301.92 10.35 4364 483432 230428 62770798
Abdominal discomfort 1178.81 10.35 5233 482563 315652 62685574
Alopecia 1176.94 10.35 5420 482376 332116 62669110
Wound 1160.45 10.35 3310 484486 159953 62841273
Maternal exposure during pregnancy 1053.71 10.35 3898 483898 216164 62785062
Rheumatoid arthritis 1048.76 10.35 4291 483505 249528 62751698
Synovitis 960.81 10.35 3389 484407 183529 62817697
Anti-cyclic citrullinated peptide antibody positive 885.20 10.35 2417 485379 113795 62887431
Pericarditis 881.93 10.35 2613 485183 128966 62872260
Completed suicide 878.99 10.35 62 487734 145611 62855615
Contraindicated product administered 874.56 10.35 3649 484147 213999 62787227
Swelling 855.30 10.35 4279 483517 271099 62730127
Discomfort 854.25 10.35 3028 484768 164346 62836880
Infusion related reaction 831.25 10.35 3911 483885 241610 62759616
Joint swelling 795.35 10.35 4761 483035 322905 62678321
Toxicity to various agents 691.19 10.35 533 487263 246717 62754509
Pain 681.77 10.35 8673 479123 731955 62269271
Death 575.76 10.35 1264 486532 373117 62628109
Product use issue 562.50 10.35 3248 484548 217272 62783954
Duodenal ulcer perforation 562.33 10.35 1709 486087 85500 62915726
Rheumatoid factor positive 552.63 10.35 1663 486133 82743 62918483
Helicobacter infection 548.24 10.35 1764 486032 91021 62910205
Hepatic enzyme increased 503.51 10.35 2961 484835 199367 62801859
Arthralgia 450.34 10.35 6496 481300 563214 62438012
Therapeutic product effect decreased 409.11 10.35 2713 485083 190474 62810752
Drug intolerance 407.50 10.35 3887 483909 304774 62696452
Drug interaction 405.04 10.35 712 487084 228419 62772807
Musculoskeletal stiffness 388.68 10.35 2589 485207 182029 62819197
Intentional overdose 379.48 10.35 58 487738 74094 62927132
Psoriatic arthropathy 379.05 10.35 1550 486246 89970 62911256
Treatment failure 349.68 10.35 2672 485124 196371 62804855
Drug abuse 342.21 10.35 70 487726 72448 62928778
Exposure during pregnancy 338.03 10.35 2199 485597 153348 62847878
Febrile neutropenia 313.63 10.35 269 487527 118180 62883046
Hip arthroplasty 285.04 10.35 910 486886 46736 62954490
Hypersensitivity 284.64 10.35 3468 484328 289217 62712009
Knee arthroplasty 276.27 10.35 981 486815 53225 62948001
Suicide attempt 257.71 10.35 74 487722 60844 62940382
Disease progression 255.62 10.35 341 487455 122417 62878809
Constipation 252.35 10.35 884 486912 224059 62777167
Rheumatic fever 250.28 10.35 815 486981 42296 62958930
Acute kidney injury 249.81 10.35 1107 486689 262308 62738918
Impaired healing 245.27 10.35 1486 486310 101056 62900170
Cardiac arrest 241.54 10.35 213 487583 92332 62908894
Depressed level of consciousness 240.38 10.35 88 487708 61990 62939236
Malignant neoplasm progression 235.61 10.35 172 487624 81949 62919277
Nasopharyngitis 225.88 10.35 2963 484833 251294 62749932
Overdose 220.49 10.35 339 487457 114739 62886487
Swollen joint count increased 217.82 10.35 691 487105 35363 62965863
Nausea 212.65 10.35 4976 482820 849495 62151731
Folliculitis 212.12 10.35 1085 486711 69232 62931994
Diarrhoea 209.30 10.35 4058 483738 711308 62289918
Blister 208.17 10.35 1707 486089 128107 62873119
Muscle injury 206.78 10.35 1022 486774 64323 62936903
Neutropenia 198.06 10.35 685 487111 174320 62826906
Red blood cell sedimentation rate abnormal 190.53 10.35 450 487346 19332 62981894
Device expulsion 186.43 10.35 24 487772 34898 62966328
Sleep disorder due to general medical condition, insomnia type 181.38 10.35 839 486957 51378 62949848
Sedation 179.91 10.35 39 487757 38770 62962456
Asthenia 171.57 10.35 2003 485793 381601 62619625
Irritable bowel syndrome 170.93 10.35 1152 486644 81260 62919966
Bradycardia 167.59 10.35 189 487607 73038 62928188
Hypotension 167.54 10.35 1316 486480 271288 62729938
Hyponatraemia 166.48 10.35 384 487412 111516 62889710
Electrocardiogram QT prolonged 165.21 10.35 129 487667 59401 62941825
Lower respiratory tract infection 164.71 10.35 1647 486149 130660 62870566
Tremor 162.48 10.35 499 487297 131740 62869486
C-reactive protein abnormal 160.36 10.35 741 487055 45355 62955871
Lactic acidosis 159.21 10.35 48 487748 38239 62962987
Somnolence 157.40 10.35 771 487025 177914 62823312
Anxiety 154.11 10.35 1008 486788 216533 62784693
Sickle cell anaemia with crisis 152.96 10.35 209 487587 5794 62995432
Rash 152.38 10.35 5499 482297 555372 62445854
Hyperhidrosis 150.20 10.35 383 487413 107453 62893773
Cardiac failure 144.12 10.35 292 487504 88850 62912376
Blood cholesterol increased 142.45 10.35 1221 486575 92811 62908415
Condition aggravated 138.21 10.35 4056 483740 398161 62603065
Renal failure 137.49 10.35 454 487342 117198 62884028
Agitation 136.99 10.35 154 487642 59603 62941623
Dyspnoea 135.96 10.35 3957 483839 657356 62343870
Neuropathy peripheral 134.65 10.35 436 487360 113231 62887995
Liver injury 133.98 10.35 860 486936 59660 62941566
Osteoarthritis 133.57 10.35 1217 486579 94126 62907100
Fatigue 131.33 10.35 8194 479602 879834 62121392
Drug ineffective 131.19 10.35 9508 478288 1035257 61965969
Type 2 diabetes mellitus 127.79 10.35 885 486911 62983 62938243
Drug reaction with eosinophilia and systemic symptoms 125.95 10.35 51 487745 33785 62967441
Vomiting 124.81 10.35 3310 484486 556307 62444919
Rhabdomyolysis 123.54 10.35 94 487702 43857 62957369
Respiratory arrest 123.49 10.35 48 487748 32597 62968629
Intentional product use issue 121.24 10.35 1509 486287 126383 62874843
Syncope 121.24 10.35 477 487319 116908 62884318
Fibromyalgia 120.62 10.35 1042 486754 79378 62921848
Multiple sclerosis relapse 120.05 10.35 117 487679 48361 62952865
Tachycardia 117.70 10.35 487 487309 117669 62883557
Arthritis 117.39 10.35 1385 486411 114536 62886690
Anaemia 116.50 10.35 1571 486225 291859 62709367
Neoplasm progression 115.72 10.35 68 487728 36360 62964866
Dizziness 115.66 10.35 2471 485325 427454 62573772
Cognitive disorder 115.16 10.35 156 487640 55659 62945567
Intentional self-injury 110.87 10.35 30 487766 25657 62975569
Pregnancy 108.00 10.35 564 487232 36272 62964954
Sopor 107.48 10.35 20 487776 22144 62979082
Ill-defined disorder 106.71 10.35 1028 486768 80727 62920499
Myalgia 105.21 10.35 676 487120 145853 62855373
Serotonin syndrome 102.33 10.35 46 487750 28636 62972590
Cardio-respiratory arrest 101.59 10.35 191 487605 59768 62941458
Hypoxia 100.84 10.35 191 487605 59601 62941625
Live birth 100.47 10.35 427 487369 25203 62976023
Feeling abnormal 99.83 10.35 698 487098 147694 62853532
Thrombocytopenia 99.26 10.35 716 487080 150441 62850785
Drug withdrawal syndrome 97.99 10.35 43 487753 27151 62974075
Balance disorder 97.77 10.35 327 487469 84095 62917131
Hypoglycaemia 97.72 10.35 196 487600 59869 62941357
Drug hypersensitivity 97.02 10.35 1741 486055 308946 62692280
Coma 96.41 10.35 220 487576 64144 62937082
Dehydration 95.50 10.35 861 486935 172493 62828733
Renal impairment 95.12 10.35 353 487443 88002 62913224
Respiratory failure 93.44 10.35 433 487363 101425 62899801
Vision blurred 92.72 10.35 377 487419 91547 62909679
No adverse event 91.35 10.35 110 487686 41295 62959931
Blood pressure fluctuation 90.99 10.35 639 487157 45678 62955548
Peripheral swelling 90.13 10.35 2678 485118 263264 62737962
Abortion spontaneous 89.17 10.35 645 487151 46550 62954676
Seizure 89.15 10.35 624 487172 132010 62869216
Joint effusion 88.82 10.35 311 487485 16749 62984477
Blood pressure diastolic abnormal 88.08 10.35 279 487517 14263 62986963
Drug dependence 87.77 10.35 39 487757 24444 62976782
Chest discomfort 87.53 10.35 491 487305 109478 62891748
Hepatic failure 87.19 10.35 87 487709 35569 62965657
Blood pressure systolic abnormal 86.81 10.35 263 487533 13123 62988103
Red blood cell sedimentation rate increased 86.53 10.35 607 487189 43375 62957851
Contusion 84.54 10.35 1621 486175 148423 62852803
Orthostatic hypotension 84.18 10.35 92 487704 36068 62965158
Metabolic acidosis 84.16 10.35 135 487661 44934 62956292
Cardiac failure congestive 84.15 10.35 394 487402 92039 62909187
Hyperglycaemia 83.39 10.35 120 487676 41747 62959479
Blood glucose increased 81.06 10.35 349 487447 83407 62917819
Hallucination 80.78 10.35 189 487607 54628 62946598
Foot deformity 79.96 10.35 424 487372 27429 62973797
Insomnia 77.42 10.35 1175 486621 214077 62787149
Infection 76.88 10.35 2305 485491 226868 62774358
Angioedema 76.76 10.35 158 487638 47807 62953419
Macular degeneration 76.72 10.35 46 487750 24330 62976896
Encephalopathy 76.62 10.35 111 487685 38509 62962717
Sinusitis 76.12 10.35 2280 485516 224373 62776853
Intentional product misuse 76.12 10.35 228 487568 60689 62940537
Drug resistance 75.44 10.35 41 487755 22892 62978334
White blood cell count decreased 75.25 10.35 694 487102 138410 62862816
Sedation complication 74.99 10.35 9 487787 13813 62987413
Neutrophil count decreased 74.22 10.35 206 487590 56200 62945026
Disability assessment scale score increased 74.11 10.35 107 487689 3126 62998100
Product quality issue 73.22 10.35 101 487695 35764 62965462
Palmar-plantar erythrodysaesthesia syndrome 73.05 10.35 43 487753 22972 62978254
Hepatic function abnormal 72.46 10.35 108 487688 37034 62964192
Disturbance in attention 71.67 10.35 114 487682 38075 62963151
Stomatitis 71.54 10.35 1479 486317 137246 62863980
Drug ineffective for unapproved indication 71.49 10.35 94 487702 33969 62967257
Psoriasis 71.13 10.35 999 486797 85958 62915268
Ejection fraction decreased 70.49 10.35 42 487754 22290 62978936
Blood pressure systolic increased 70.46 10.35 613 487183 46784 62954442
Pulmonary fibrosis 70.05 10.35 535 487261 39274 62961952
C-reactive protein increased 69.97 10.35 1069 486727 93638 62907588
Pulmonary embolism 69.85 10.35 567 487229 116117 62885109
Multiple organ dysfunction syndrome 69.77 10.35 214 487582 56538 62944688
Altered state of consciousness 69.58 10.35 55 487741 25175 62976051
Grip strength decreased 69.35 10.35 347 487449 21940 62979286
Fluid retention 69.23 10.35 231 487565 59455 62941771
Creatinine renal clearance decreased 68.61 10.35 20 487776 16288 62984938
Asthma 67.88 10.35 639 487157 126922 62874304
Platelet count decreased 67.36 10.35 569 487227 115553 62885673
Product dose omission issue 67.22 10.35 1332 486464 232981 62768245
Mental status changes 67.20 10.35 126 487670 39473 62961753
Bone erosion 66.24 10.35 291 487505 17426 62983800
Weight increased 65.93 10.35 2538 485258 258254 62742972
Muscle spasms 64.82 10.35 828 486968 155322 62845904
Depression 63.85 10.35 1093 486703 195399 62805827
Myocardial infarction 63.71 10.35 477 487319 99416 62901810
Blood calcium decreased 63.02 10.35 66 487730 26385 62974841
Metastases to bone 62.94 10.35 42 487754 20977 62980249
Osteoporosis 62.92 10.35 696 487100 56642 62944584
Joint range of motion decreased 62.88 10.35 446 487350 31982 62969244
Hyperkalaemia 62.72 10.35 210 487586 53993 62947233
Inflammation 62.46 10.35 933 486863 81340 62919886
Emotional distress 62.19 10.35 96 487700 32453 62968773
Basal cell carcinoma 62.08 10.35 398 487398 27593 62973633
Juvenile idiopathic arthritis 62.00 10.35 100 487696 3226 62998000
Suicidal ideation 61.07 10.35 259 487537 62162 62939064
Loss of personal independence in daily activities 61.04 10.35 1069 486727 96221 62905005
Drug tolerance decreased 60.10 10.35 280 487516 17193 62984033
Anaphylactic reaction 60.01 10.35 282 487514 65818 62935408
Flushing 59.88 10.35 335 487461 74752 62926474
Loss of consciousness 59.77 10.35 599 487197 117522 62883704
Mydriasis 59.69 10.35 10 487786 11946 62989280
Dysphagia 58.90 10.35 418 487378 88167 62913059
Leukopenia 58.86 10.35 350 487446 76940 62924286
Diabetic ketoacidosis 58.72 10.35 43 487753 20462 62980764
Cytomegalovirus infection 58.63 10.35 45 487751 20907 62980319
Hepatocellular injury 58.04 10.35 75 487721 27306 62973920
Palpitations 57.42 10.35 571 487225 112199 62889027
Joint laxity 57.14 10.35 82 487714 2382 62998844
Muscle spasticity 57.03 10.35 50 487746 21744 62979482
Cholestasis 57.02 10.35 86 487710 29348 62971878
Joint destruction 56.74 10.35 139 487657 6113 62995113
Bone pain 56.41 10.35 222 487574 54419 62946807
Cytokine release syndrome 55.89 10.35 20 487776 14294 62986932
Hypokalaemia 55.64 10.35 519 487277 103285 62897941
Pulmonary arterial hypertension 55.30 10.35 55 487741 22522 62978704
Restlessness 55.20 10.35 88 487708 29365 62971861
Blood pressure decreased 54.66 10.35 285 487511 64737 62936489
Caesarean section 54.28 10.35 267 487529 16765 62984461
Blood alkaline phosphatase increased 54.27 10.35 160 487636 42807 62958419
Disorientation 54.23 10.35 141 487655 39311 62961915
Blood creatine phosphokinase increased 54.17 10.35 94 487702 30336 62970890
Poisoning 53.74 10.35 19 487777 13681 62987545
Dysgeusia 53.34 10.35 182 487614 46528 62954698
Shock 53.19 10.35 61 487735 23402 62977824
Blood bilirubin increased 53.17 10.35 130 487666 37010 62964216
Wrong technique in product usage process 53.11 10.35 272 487524 62068 62939158
Gamma-glutamyltransferase increased 52.86 10.35 114 487682 33917 62967309
Drug level increased 52.75 10.35 58 487738 22678 62978548
Respiratory depression 52.15 10.35 20 487776 13695 62987531
Metastases to liver 51.93 10.35 63 487733 23576 62977650
Unresponsive to stimuli 51.93 10.35 114 487682 33702 62967524
Dysarthria 51.83 10.35 162 487634 42549 62958677
Osteonecrosis of jaw 51.83 10.35 121 487675 35002 62966224
Blood pressure diastolic decreased 51.68 10.35 325 487471 22381 62978845
Ascites 51.19 10.35 152 487644 40576 62960650
Deep vein thrombosis 51.16 10.35 405 487391 83395 62917831
Polyarthritis 51.13 10.35 183 487613 9963 62991263
Ventricular tachycardia 50.89 10.35 47 487749 19932 62981294
Speech disorder 50.80 10.35 152 487644 40477 62960749
Pain in jaw 50.68 10.35 168 487628 43328 62957898
Hospitalisation 50.65 10.35 414 487382 84667 62916559
Rheumatoid nodule 50.51 10.35 263 487533 16892 62984334
Dyspnoea exertional 50.30 10.35 265 487531 60037 62941189
Sepsis 50.30 10.35 850 486946 152273 62848953
Foetal exposure during pregnancy 49.94 10.35 418 487378 31544 62969682
Anaphylactic shock 49.82 10.35 65 487731 23568 62977658
Disability 49.76 10.35 275 487521 18072 62983154
General physical health deterioration 48.98 10.35 1952 485844 199450 62801776
Atrial fibrillation 48.94 10.35 617 487179 116019 62885207
Adverse event 48.52 10.35 759 487037 66800 62934426
Injection site erythema 47.98 10.35 902 486894 82272 62918954
Injection site pruritus 47.84 10.35 544 487252 44572 62956654
Disseminated intravascular coagulation 47.14 10.35 46 487750 19005 62982221
Device dislocation 47.05 10.35 78 487718 25627 62975599
Cerebral haemorrhage 46.85 10.35 104 487692 30625 62970601
Hypothermia 46.57 10.35 23 487773 13558 62987668
Premature labour 46.46 10.35 205 487591 12299 62988927
Dry skin 46.34 10.35 252 487544 56635 62944591
Blood creatinine increased 46.31 10.35 441 487355 87403 62913823
Gestational diabetes 46.28 10.35 156 487640 8240 62992986
Abnormal behaviour 46.13 10.35 58 487738 21368 62979858
Chronic kidney disease 45.88 10.35 186 487610 45212 62956014
Acute hepatic failure 45.64 10.35 44 487752 18283 62982943
Urticaria 45.30 10.35 950 486846 164852 62836374
Tuberculosis 44.88 10.35 188 487608 11023 62990203
Extrapyramidal disorder 44.80 10.35 23 487773 13261 62987965
Haemorrhage 44.55 10.35 280 487516 60742 62940484
Gastrointestinal disorder 44.22 10.35 1321 486475 129918 62871308
Pulmonary oedema 44.19 10.35 244 487552 54629 62946597
Respiratory disorder 44.13 10.35 153 487643 38929 62962297
Back pain 44.13 10.35 1622 486174 262523 62738703
Posterior reversible encephalopathy syndrome 43.94 10.35 41 487755 17304 62983922
Torsade de pointes 43.72 10.35 24 487772 13327 62987899
Cerebrovascular accident 43.63 10.35 576 487220 107448 62893778
Vertigo 43.61 10.35 275 487521 59612 62941614
COVID-19 43.55 10.35 609 487187 112494 62888732
Device difficult to use 43.38 10.35 22 487774 12774 62988452
Aspartate aminotransferase increased 43.13 10.35 464 487332 89813 62911413
Pleural effusion 42.96 10.35 483 487313 92727 62908499
Product administration error 42.84 10.35 66 487730 22331 62978895
Dyskinesia 42.75 10.35 116 487680 31886 62969340
Infective pulmonary exacerbation of cystic fibrosis 42.66 10.35 8 487788 8809 62992417
Neck deformity 42.62 10.35 66 487730 2055 62999171
Psychotic disorder 42.59 10.35 83 487713 25629 62975597
Mobility decreased 42.59 10.35 1226 486570 119933 62881293
Schizophrenia 42.24 10.35 12 487784 9940 62991286
Fall 42.14 10.35 2526 485270 389808 62611418
Joint stiffness 40.92 10.35 497 487299 41372 62959854
Neurotoxicity 40.92 10.35 42 487754 16948 62984278
Arrhythmia 40.63 10.35 153 487643 37987 62963239
Accidental exposure to product 39.96 10.35 95 487701 27310 62973916
International normalised ratio increased 39.86 10.35 202 487594 46223 62955003
Multiple fractures 39.71 10.35 151 487645 8467 62992759
Decreased appetite 39.63 10.35 1552 486244 249500 62751726
Gastrointestinal haemorrhage 39.27 10.35 416 487380 80760 62920466
Memory impairment 39.21 10.35 564 487232 103694 62897532
Akathisia 38.88 10.35 11 487785 9135 62992091
Coagulopathy 38.86 10.35 61 487735 20483 62980743
Polyneuropathy 38.74 10.35 33 487763 14556 62986670
Inappropriate antidiuretic hormone secretion 38.64 10.35 37 487759 15425 62985801
Colitis 38.42 10.35 217 487579 48311 62952915
Respiratory distress 38.28 10.35 133 487663 33818 62967408
Laryngitis 38.08 10.35 242 487554 16725 62984501
Bronchospasm 38.02 10.35 46 487750 17234 62983992
Ventricular fibrillation 37.90 10.35 22 487774 11845 62989381
Chest pain 37.90 10.35 1318 486478 214641 62786585
Neuroleptic malignant syndrome 37.59 10.35 23 487773 12033 62989193
Joint dislocation 37.28 10.35 260 487536 18540 62982686
Hypomania 37.28 10.35 3 487793 6327 62994899
Nodule 37.23 10.35 283 487513 20743 62980483
Injection site reaction 37.03 10.35 644 487152 57880 62943346
Maternal drugs affecting foetus 36.86 10.35 106 487690 5136 62996090
Irritability 36.52 10.35 123 487673 31571 62969655
Maternal exposure before pregnancy 36.51 10.35 135 487661 7468 62993758
Enthesopathy 36.50 10.35 147 487649 8467 62992759
Disease recurrence 36.40 10.35 103 487693 27927 62973299
Pulmonary hypertension 36.33 10.35 154 487642 36969 62964257
Acute respiratory failure 36.30 10.35 139 487657 34346 62966880
Withdrawal syndrome 36.30 10.35 61 487735 19936 62981290
Depressed mood 36.16 10.35 172 487624 40019 62961207
Hemiparesis 36.15 10.35 78 487718 23204 62978022
Product use in unapproved indication 35.94 10.35 1074 486722 178006 62823220
Lethargy 35.91 10.35 267 487529 55740 62945486
Alanine aminotransferase increased 35.72 10.35 571 487225 103199 62898027
Face oedema 35.46 10.35 63 487733 20149 62981077
Brain oedema 35.44 10.35 34 487762 14161 62987065
Parkinsonism 35.31 10.35 18 487778 10421 62990805
Heart rate decreased 35.09 10.35 518 487278 45042 62956184
Melaena 34.88 10.35 118 487678 30247 62970979
Hypomagnesaemia 34.86 10.35 109 487687 28628 62972598
Thrombotic microangiopathy 34.56 10.35 19 487777 10542 62990684
Pancreatitis acute 34.42 10.35 101 487695 27065 62974161
Musculoskeletal pain 34.17 10.35 940 486856 91337 62909889
Mania 34.05 10.35 27 487769 12340 62988886
Stress cardiomyopathy 33.95 10.35 15 487781 9435 62991791
Blood potassium decreased 33.77 10.35 187 487609 41839 62959387
Obesity 33.51 10.35 365 487431 29587 62971639
Blood pressure diastolic increased 33.40 10.35 159 487637 9851 62991375
Ankylosing spondylitis 33.24 10.35 164 487632 10310 62990916
Metastases to central nervous system 33.17 10.35 31 487765 13074 62988152
Myelosuppression 33.12 10.35 84 487712 23619 62977607
Hepatotoxicity 33.05 10.35 159 487637 36882 62964344
Accidental overdose 33.04 10.35 82 487714 23227 62977999
Facet joint syndrome 32.96 10.35 182 487614 11956 62989270
Immune reconstitution inflammatory syndrome 32.91 10.35 4 487792 6080 62995146
Nightmare 32.63 10.35 61 487735 19133 62982093
Abdominal pain 32.61 10.35 1883 485913 291573 62709653
Diabetes mellitus inadequate control 32.50 10.35 41 487755 15085 62986141
Lupus-like syndrome 32.40 10.35 215 487581 15080 62986146
Prescribed underdose 32.39 10.35 360 487436 29329 62971897
Dystonia 32.34 10.35 35 487761 13784 62987442
Eosinophilia 32.30 10.35 80 487716 22676 62978550
Ventricular septal defect 32.22 10.35 90 487706 4288 62996938
Acute generalised exanthematous pustulosis 32.14 10.35 23 487773 11076 62990150
Muscle twitching 32.14 10.35 64 487732 19604 62981622
Panic attack 32.09 10.35 78 487718 22253 62978973
Toxic skin eruption 32.01 10.35 31 487765 12854 62988372
Tenderness 32.00 10.35 289 487507 22289 62978937
Haematotoxicity 31.97 10.35 16 487780 9360 62991866
Exposure to toxic agent 31.95 10.35 3 487793 5584 62995642
Peripheral venous disease 31.85 10.35 216 487580 15261 62985965
Transplant rejection 31.66 10.35 22 487774 10758 62990468
Plasma cell myeloma 31.52 10.35 155 487641 35750 62965476
Headache 31.48 10.35 4325 483471 628916 62372310
Atrioventricular block complete 31.42 10.35 12 487784 8239 62992987
Abdominal distension 31.37 10.35 472 487324 86143 62915083
Second primary malignancy 31.25 10.35 11 487785 7942 62993284
Tumour lysis syndrome 31.17 10.35 15 487781 8975 62992251
Tenosynovitis 31.11 10.35 197 487599 13598 62987628
Wheelchair user 31.02 10.35 113 487683 6206 62995020
Skin exfoliation 30.83 10.35 199 487597 42903 62958323
Fear 30.60 10.35 46 487750 15720 62985506
Unevaluable event 30.59 10.35 250 487546 51136 62950090
Aphasia 30.41 10.35 140 487656 32860 62968366
Limb deformity 30.17 10.35 83 487713 3919 62997307
Latent tuberculosis 30.04 10.35 64 487732 2563 62998663
Prescribed overdose 29.80 10.35 397 487399 33756 62967470
Localised infection 29.69 10.35 359 487437 29851 62971375
Injection site swelling 29.57 10.35 522 487274 47050 62954176
Lip dry 29.54 10.35 212 487584 15258 62985968
Rash erythematous 29.53 10.35 198 487598 42312 62958914
Small for dates baby 29.49 10.35 79 487717 3672 62997554
Agranulocytosis 29.33 10.35 97 487699 25037 62976189
Obstructive airways disorder 29.20 10.35 73 487723 20626 62980600
Miosis 29.18 10.35 10 487786 7343 62993883
Skin ulcer 29.18 10.35 479 487317 42566 62958660
Multiple allergies 29.05 10.35 38 487758 13764 62987462
Haematoma 29.05 10.35 153 487643 34667 62966559
Status epilepticus 29.03 10.35 45 487751 15188 62986038
Proteinuria 29.02 10.35 65 487731 19080 62982146
Leukocytosis 28.97 10.35 102 487694 25833 62975393
Hypervolaemia 28.97 10.35 116 487680 28297 62972929
Nervousness 28.80 10.35 131 487665 30848 62970378
Sinus tachycardia 28.77 10.35 93 487703 24175 62977051
Cytopenia 28.71 10.35 28 487768 11573 62989653
Dislocation of vertebra 28.69 10.35 137 487659 8498 62992728
Stevens-Johnson syndrome 28.63 10.35 97 487699 24853 62976373
Premature rupture of membranes 28.61 10.35 94 487702 4899 62996327
Tardive dyskinesia 28.26 10.35 15 487781 8487 62992739
Rhinitis allergic 28.23 10.35 29 487767 11698 62989528
Procedural pain 28.20 10.35 79 487717 21490 62979736
Lymphocyte count decreased 28.10 10.35 128 487668 30129 62971097
Retinitis 28.08 10.35 108 487688 6088 62995138
Angina pectoris 28.08 10.35 127 487669 29951 62971275
Paralysis 28.04 10.35 21 487775 9879 62991347
Metastases to lung 27.99 10.35 34 487762 12716 62988510
Pyrexia 27.98 10.35 3176 484620 467302 62533924
Complication associated with device 27.95 10.35 55 487741 16923 62984303
Lip swelling 27.91 10.35 133 487663 30930 62970296
Malignant mediastinal neoplasm 27.67 10.35 44 487752 1402 62999824
Tenosynovitis stenosans 27.61 10.35 72 487724 3292 62997934
Jaundice 27.61 10.35 123 487673 29128 62972098
Pre-eclampsia 27.57 10.35 141 487655 8992 62992234
Therapeutic response decreased 27.57 10.35 643 487153 60882 62940344
Red blood cell sedimentation rate 27.47 10.35 91 487705 4763 62996463
Myoclonus 27.36 10.35 50 487746 15818 62985408
Paraesthesia 27.28 10.35 959 486837 156007 62845219
Glycosylated haemoglobin increased 27.28 10.35 33 487763 12365 62988861
Aggression 27.20 10.35 91 487705 23407 62977819
Sleep apnoea syndrome 27.20 10.35 123 487673 29010 62972216
Chills 27.16 10.35 663 487133 112715 62888511
Clostridium difficile colitis 27.14 10.35 75 487721 20494 62980732
Asphyxia 27.09 10.35 7 487789 6174 62995052
Urinary retention 27.07 10.35 130 487666 30171 62971055
Haemophagocytic lymphohistiocytosis 27.06 10.35 25 487771 10602 62990624
Acute myeloid leukaemia 26.99 10.35 57 487739 17090 62984136
Maternal exposure timing unspecified 26.95 10.35 117 487679 6970 62994256
Hyperlipidaemia 26.85 10.35 70 487726 19501 62981725
Bradyphrenia 26.84 10.35 10 487786 6970 62994256
Tachypnoea 26.83 10.35 58 487738 17244 62983982
Anti-cyclic citrullinated peptide antibody 26.80 10.35 113 487683 6645 62994581
Infusion site pain 26.62 10.35 56 487740 16813 62984413
Substance abuse 26.40 10.35 3 487793 4804 62996422
Wound infection 26.35 10.35 266 487530 21144 62980082
Cardiogenic shock 26.27 10.35 62 487734 17870 62983356
Device use error 26.27 10.35 6 487790 5755 62995471
Hypophagia 26.27 10.35 137 487659 31122 62970104
Body temperature decreased 26.25 10.35 255 487541 20064 62981162
Haemorrhage intracranial 26.19 10.35 39 487757 13380 62987846
Cough 26.11 10.35 1916 485880 290827 62710399
Crying 25.94 10.35 92 487704 23251 62977975
Multiple sclerosis 25.81 10.35 98 487698 24274 62976952
Erythema multiforme 25.81 10.35 24 487772 10145 62991081
Product adhesion issue 25.78 10.35 3 487793 4716 62996510
Genital haemorrhage 25.78 10.35 12 487784 7320 62993906
Subdural haematoma 25.74 10.35 44 487752 14284 62986942
Adjustment disorder with depressed mood 25.73 10.35 150 487646 10054 62991172
Device related infection 25.46 10.35 93 487703 23299 62977927
Anhedonia 25.45 10.35 28 487768 10946 62990280
Synovial cyst 25.43 10.35 152 487644 10281 62990945
Deep vein thrombosis postoperative 25.42 10.35 162 487634 11207 62990019
Cerebral infarction 25.35 10.35 96 487700 23797 62977429
Haemoptysis 25.22 10.35 124 487672 28602 62972624
Dysmorphism 25.18 10.35 55 487741 2241 62998985
Smear cervix abnormal 25.16 10.35 64 487732 2882 62998344
Blood glucose decreased 25.05 10.35 80 487716 20872 62980354
Paraesthesia oral 24.83 10.35 71 487725 19185 62982041
Ischaemic stroke 24.81 10.35 64 487732 17893 62983333
Femur fracture 24.48 10.35 454 487342 41302 62959924
Chronic sinusitis 24.42 10.35 38 487758 12805 62988421
Hallucination, visual 24.27 10.35 72 487724 19226 62982000
Pain in extremity 24.21 10.35 2905 484891 328581 62672645
Vascular device infection 24.15 10.35 13 487783 7299 62993927
Synovial fluid analysis 24.14 10.35 56 487740 2377 62998849
Cardiomyopathy 24.04 10.35 63 487733 17521 62983705
Bursitis 23.94 10.35 409 487387 36632 62964594
Acute graft versus host disease 23.74 10.35 3 487793 4425 62996801
Hot flush 23.61 10.35 265 487531 50894 62950332
Uterine perforation 23.56 10.35 12 487784 6951 62994275
Neck mass 23.56 10.35 71 487725 3532 62997694
Cardiac failure acute 23.55 10.35 23 487773 9500 62991726
Pancreatitis 23.47 10.35 252 487544 48803 62952423
Pseudomonas infection 23.47 10.35 31 487765 11182 62990044
Rash maculo-papular 23.46 10.35 146 487650 31750 62969476
Hallucination, auditory 23.39 10.35 39 487757 12785 62988441
Swollen tongue 23.23 10.35 164 487632 34636 62966590
Temperature regulation disorder 23.22 10.35 9 487787 6123 62995103
Breast cancer stage I 23.12 10.35 12 487784 6877 62994349
Personality disorder 22.89 10.35 8 487788 5803 62995423
Muscle rigidity 22.86 10.35 33 487763 11467 62989759
Psychomotor hyperactivity 22.81 10.35 29 487767 10634 62990592
Complication of device insertion 22.80 10.35 15 487781 7549 62993677
Lymphoedema 22.80 10.35 34 487762 11658 62989568
Oedema peripheral 22.69 10.35 1207 486589 188304 62812922
Mental disorder 22.69 10.35 112 487684 25807 62975419
Infusion site swelling 22.58 10.35 25 487771 9745 62991481
Acidosis 22.56 10.35 32 487764 11201 62990025
Body height below normal 22.49 10.35 51 487745 2132 62999094
Malignant melanoma 22.49 10.35 157 487639 11199 62990027
Placental disorder 22.48 10.35 41 487755 1463 62999763
Malaise 22.42 10.35 2826 484970 413128 62588098
Feeling hot 22.39 10.35 263 487533 50091 62951135
Graft versus host disease 22.38 10.35 12 487784 6751 62994475
Cholecystitis chronic 22.35 10.35 28 487768 10333 62990893
Complication of device removal 22.20 10.35 6 487790 5136 62996090
Rotator cuff repair 22.15 10.35 50 487746 2084 62999142
Device breakage 22.09 10.35 34 487762 11508 62989718
Muscular weakness 22.08 10.35 744 487052 121609 62879617
Atrioventricular block 21.94 10.35 16 487780 7631 62993595
Pericardial effusion 21.89 10.35 138 487658 29920 62971306
Paradoxical drug reaction 21.81 10.35 3 487793 4149 62997077
Urinary incontinence 21.79 10.35 150 487646 31864 62969362
Loose body in joint 21.73 10.35 37 487759 1249 62999977
Exostosis 21.54 10.35 221 487575 17641 62983585
Generalised oedema 21.38 10.35 57 487739 15761 62985465
Synovial disorder 21.32 10.35 48 487748 1997 62999229
Developmental hip dysplasia 21.27 10.35 38 487758 1334 62999892
Hypothyroidism 21.21 10.35 217 487579 42415 62958811
Ketoacidosis 21.12 10.35 4 487792 4374 62996852
Rectal haemorrhage 21.07 10.35 258 487538 48772 62952454
Nasal polyps 21.05 10.35 10 487786 6029 62995197
Arthritis infective 20.96 10.35 102 487694 6376 62994850
Mood altered 20.79 10.35 52 487744 14691 62986535
Rheumatoid lung 20.77 10.35 71 487725 3777 62997449
Cyanosis 20.71 10.35 64 487732 16871 62984355
Delirium 20.58 10.35 269 487527 50272 62950954
Multiple-drug resistance 20.57 10.35 7 487789 5163 62996063
Eating disorder 20.44 10.35 76 487720 18940 62982286
Purpura 20.42 10.35 35 487761 11350 62989876
Respiration abnormal 20.35 10.35 12 487784 6405 62994821
Right ventricular failure 20.29 10.35 66 487730 17122 62984104
Pemphigoid 20.26 10.35 16 487780 7328 62993898
Hereditary angioedema 20.21 10.35 17 487779 7545 62993681
Affective disorder 20.20 10.35 11 487785 6135 62995091
Atrial septal defect 20.17 10.35 106 487690 6832 62994394
Myocarditis 20.16 10.35 30 487766 10295 62990931
Rebound effect 20.08 10.35 5 487791 4521 62996705
Bronchopulmonary aspergillosis 20.06 10.35 22 487774 8613 62992613
Foetal anticonvulsant syndrome 20.05 10.35 24 487772 581 63000645
Coronary artery disease 19.97 10.35 156 487640 32221 62969005
Bundle branch block left 19.96 10.35 15 487781 7044 62994182
Infusion site erythema 19.96 10.35 37 487759 11642 62989584
Product preparation error 19.88 10.35 11 487785 6081 62995145
Renal disorder 19.82 10.35 160 487636 32814 62968412
Pulmonary congestion 19.79 10.35 68 487728 17350 62983876
Blood parathyroid hormone decreased 19.76 10.35 136 487660 9655 62991571
Dementia 19.62 10.35 76 487720 18718 62982508
Spinal stenosis 19.62 10.35 188 487608 14737 62986489
Injection site rash 19.58 10.35 226 487570 18583 62982643
Cardiac disorder 19.41 10.35 274 487522 50542 62950684
Visual acuity reduced 19.29 10.35 94 487702 21732 62979494
Hemiplegia 19.28 10.35 26 487770 9297 62991929
Fear of injection 19.17 10.35 107 487689 7057 62994169
Clear cell renal cell carcinoma 19.13 10.35 38 487758 1447 62999779
Lupus vulgaris 19.13 10.35 94 487702 5900 62995326
Sexual dysfunction 18.98 10.35 5 487791 4354 62996872
Febrile bone marrow aplasia 18.93 10.35 17 487779 7308 62993918
Diabetes mellitus 18.90 10.35 308 487488 55502 62945724
Aspiration 18.88 10.35 34 487762 10817 62990409
Delusion 18.87 10.35 40 487756 11977 62989249
Skin papilloma 18.87 10.35 82 487714 4887 62996339
Stillbirth 18.86 10.35 102 487694 6648 62994578
Human antichimeric antibody positive 18.73 10.35 41 487755 1673 62999553
Granuloma skin 18.73 10.35 120 487676 8317 62992909
Anuria 18.71 10.35 43 487753 12508 62988718
Toxic epidermal necrolysis 18.61 10.35 116 487680 25218 62976008
Epistaxis 18.60 10.35 421 487375 72304 62928922
Acute chest syndrome 18.57 10.35 27 487769 794 63000432
Antinuclear antibody positive 18.52 10.35 115 487681 7884 62993342
Sinus bradycardia 18.51 10.35 54 487742 14497 62986729
Injection site bruising 18.47 10.35 437 487359 41473 62959753
Catheter site erythema 18.44 10.35 5 487791 4271 62996955
Acute myocardial infarction 18.35 10.35 158 487638 31966 62969260
Visual impairment 18.31 10.35 501 487295 83945 62917281
Pulmonary tuberculosis 18.28 10.35 76 487720 4441 62996785
Dermatitis atopic 18.27 10.35 29 487767 9695 62991531
Hypercholesterolaemia 18.20 10.35 247 487549 21087 62980139
Shock haemorrhagic 18.13 10.35 30 487766 9865 62991361
Bone marrow failure 18.13 10.35 141 487655 29149 62972077
Presyncope 18.03 10.35 132 487664 27653 62973573
Polyhydramnios 18.02 10.35 48 487748 2223 62999003
Premature delivery 18.01 10.35 330 487466 29951 62971275
Circulatory collapse 17.96 10.35 97 487699 21841 62979385
Dysuria 17.93 10.35 169 487627 33569 62967657
Hyperprolactinaemia 17.91 10.35 4 487792 3896 62997330
Tinnitus 17.87 10.35 181 487615 35447 62965779
Head injury 17.85 10.35 130 487666 27266 62973960
Jaundice cholestatic 17.76 10.35 18 487778 7306 62993920
Gastroenteritis viral 17.68 10.35 268 487528 23432 62977794
Congenital arterial malformation 17.58 10.35 17 487779 320 63000906
Pathogen resistance 17.58 10.35 14 487782 6384 62994842
Labelled drug-drug interaction medication error 17.57 10.35 49 487747 13350 62987876
Hyperthyroidism 17.56 10.35 56 487740 14617 62986609
Renal tubular necrosis 17.46 10.35 41 487755 11837 62989389
Paranoia 17.42 10.35 40 487756 11639 62989587
Tumour marker increased 17.35 10.35 8 487788 4907 62996319
Toxic encephalopathy 17.33 10.35 15 487781 6564 62994662
Aspergillus infection 17.32 10.35 22 487774 8071 62993155
Injection site pain 17.21 10.35 1188 486608 128612 62872614
Cushingoid 17.21 10.35 118 487678 8367 62992859
Hypophosphataemia 17.15 10.35 39 487757 11387 62989839
Product prescribing error 17.01 10.35 125 487671 26164 62975062
Cardiotoxicity 16.98 10.35 24 487772 8414 62992812
Myopathy 16.96 10.35 38 487758 11153 62990073
Respiratory acidosis 16.86 10.35 16 487780 6699 62994527
Erythema 16.84 10.35 1143 486653 174608 62826618
Scleritis 16.76 10.35 73 487723 4355 62996871
Anger 16.75 10.35 45 487751 12411 62988815
Acute pulmonary oedema 16.62 10.35 23 487773 8135 62993091
Klebsiella infection 16.62 10.35 25 487771 8541 62992685
Progressive multifocal leukoencephalopathy 16.60 10.35 48 487748 12923 62988303
Pulseless electrical activity 16.57 10.35 20 487776 7501 62993725
Polyuria 16.50 10.35 25 487771 8517 62992709
Troponin increased 16.48 10.35 33 487763 10088 62991138
Ulcer 16.41 10.35 287 487509 25820 62975406
Hepatitis acute 16.39 10.35 28 487768 9092 62992134
Blood urea increased 16.32 10.35 127 487669 26252 62974974
Oliguria 16.30 10.35 28 487768 9073 62992153
Tendonitis 16.29 10.35 226 487570 19389 62981837
Salivary hypersecretion 16.24 10.35 21 487775 7645 62993581
Acute respiratory distress syndrome 16.15 10.35 110 487686 23424 62977802
Breast feeding 16.11 10.35 26 487770 839 63000387
Epstein-Barr virus infection 16.10 10.35 23 487773 8027 62993199
Amylase increased 16.07 10.35 15 487781 6330 62994896
Incorrect product administration duration 16.07 10.35 41 487755 11505 62989721
Pallor 15.87 10.35 154 487642 30414 62970812
Therapy change 15.85 10.35 14 487782 6067 62995159
Eosinophil count increased 15.84 10.35 38 487758 10890 62990336
Systemic inflammatory response syndrome 15.82 10.35 12 487784 5609 62995617
Treatment noncompliance 15.81 10.35 197 487599 37128 62964098
Product administered to patient of inappropriate age 15.74 10.35 3 487793 3265 62997961
Ileus 15.73 10.35 59 487737 14666 62986560
Abnormal dreams 15.70 10.35 36 487760 10480 62990746
Postoperative wound infection 15.56 10.35 140 487656 10785 62990441
Antibody test positive 15.54 10.35 51 487745 2656 62998570
Flatulence 15.52 10.35 181 487615 34521 62966705
Mouth ulceration 15.48 10.35 347 487449 32637 62968589
Device issue 15.42 10.35 113 487683 23668 62977558
Plasma cell myeloma recurrent 15.36 10.35 3 487793 3210 62998016
Hallucinations, mixed 15.36 10.35 9 487787 4820 62996406
Full blood count decreased 15.31 10.35 127 487669 25897 62975329
Middle insomnia 15.30 10.35 48 487748 12595 62988631
Panniculitis 15.26 10.35 144 487652 11241 62989985
Product complaint 15.25 10.35 49 487747 12760 62988466
Tubulointerstitial nephritis 15.21 10.35 90 487706 19813 62981413
Fracture 15.21 10.35 223 487573 19361 62981865
Peripheral sensory neuropathy 15.19 10.35 21 487775 7430 62993796
Fracture delayed union 15.16 10.35 47 487749 2375 62998851
Sciatica 15.15 10.35 358 487438 33966 62967260
Breast cancer metastatic 14.99 10.35 45 487751 11973 62989253
Hypernatraemia 14.96 10.35 22 487774 7587 62993639
Bundle branch block right 14.95 10.35 10 487786 4988 62996238
Crohn's disease 14.94 10.35 76 487720 4837 62996389
Intracranial pressure increased 14.92 10.35 11 487785 5216 62996010
Hepatitis B reactivation 14.85 10.35 3 487793 3134 62998092
Coordination abnormal 14.83 10.35 55 487741 13718 62987508
Joint noise 14.82 10.35 70 487726 4322 62996904
Catheter site pain 14.81 10.35 9 487787 4726 62996500
Subarachnoid haemorrhage 14.76 10.35 58 487738 14225 62987001
Catatonia 14.73 10.35 8 487788 4469 62996757
Food allergy 14.73 10.35 42 487754 11359 62989867
Therapy partial responder 14.71 10.35 38 487758 10620 62990606
Injury 14.67 10.35 696 487100 72551 62928675
Product substitution issue 14.66 10.35 68 487728 15928 62985298
Short stature 14.61 10.35 22 487774 668 63000558
Blood phosphorus decreased 14.59 10.35 8 487788 4445 62996781
Haemorrhage in pregnancy 14.59 10.35 40 487756 1885 62999341
Pregnancy with contraceptive device 14.57 10.35 9 487787 4685 62996541
Neutropenic colitis 14.57 10.35 3 487793 3092 62998134
Sensitisation 14.53 10.35 4 487792 3382 62997844
Infusion site pruritus 14.44 10.35 15 487781 6020 62995206
Hepatitis cholestatic 14.41 10.35 19 487777 6859 62994367
Multiple drug therapy 14.40 10.35 5 487791 3641 62997585
Throat tightness 14.39 10.35 122 487674 24765 62976461
Gastroschisis 14.38 10.35 17 487779 406 63000820
Renal injury 14.34 10.35 32 487764 9407 62991819
Gestational hypertension 14.30 10.35 46 487750 2371 62998855
Injection site warmth 14.25 10.35 179 487617 15016 62986210
Transplant dysfunction 14.23 10.35 10 487786 4862 62996364
Somnambulism 14.16 10.35 13 487783 5530 62995696
Laryngospasm 14.12 10.35 3 487793 3025 62998201
Blood loss anaemia 14.10 10.35 30 487766 8971 62992255
Ankle arthroplasty 14.07 10.35 38 487758 1775 62999451
Restless legs syndrome 14.06 10.35 84 487712 18447 62982779
Bacteraemia 14.04 10.35 77 487719 17271 62983955
Ageusia 14.02 10.35 56 487740 13672 62987554
Dactylitis 13.93 10.35 48 487748 2564 62998662
Pulmonary haemorrhage 13.89 10.35 21 487775 7160 62994066
Polydipsia 13.88 10.35 5 487791 3559 62997667
Extra dose administered 13.87 10.35 17 487779 6333 62994893
Catheter management 13.85 10.35 3 487793 2984 62998242
Haematemesis 13.85 10.35 158 487638 30254 62970972
Thrombosis 13.82 10.35 385 487411 64370 62936856
Ear infection 13.78 10.35 388 487408 37825 62963401
Intervertebral disc degeneration 13.78 10.35 183 487613 15549 62985677
Affect lability 13.74 10.35 42 487754 11109 62990117
Talipes 13.72 10.35 34 487762 1506 62999720
Dermatitis exfoliative 13.72 10.35 13 487783 5446 62995780
Body temperature increased 13.69 10.35 202 487594 36990 62964236
Hyperbilirubinaemia 13.66 10.35 43 487753 11271 62989955
Swelling face 13.65 10.35 377 487419 63098 62938128
Bone lesion 13.65 10.35 15 487781 5866 62995360
Proctitis 13.62 10.35 13 487783 5428 62995798
Onychomycosis 13.62 10.35 106 487690 7826 62993400
Exomphalos 13.60 10.35 19 487777 538 63000688
Trigeminal neuralgia 13.60 10.35 5 487791 3514 62997712
Influenza like illness 13.58 10.35 400 487396 66424 62934802
Inadequate analgesia 13.55 10.35 3 487793 2940 62998286
Blood sodium decreased 13.53 10.35 120 487676 24132 62977094
Bradykinesia 13.46 10.35 12 487784 5176 62996050
Speech disorder developmental 13.44 10.35 21 487775 659 63000567
Drug abuser 13.42 10.35 3 487793 2920 62998306
Lymphopenia 13.42 10.35 84 487712 18243 62982983
Breast cancer female 13.42 10.35 56 487740 13503 62987723
Impaired gastric emptying 13.39 10.35 38 487758 10294 62990932
Embedded device 13.37 10.35 5 487791 3478 62997748
Autism spectrum disorder 13.36 10.35 24 487772 846 63000380
Therapy non-responder 13.30 10.35 712 487084 75189 62926037
Acute coronary syndrome 13.30 10.35 37 487759 10089 62991137
Metabolic encephalopathy 13.28 10.35 15 487781 5794 62995432
Hyperuricaemia 13.25 10.35 13 487783 5357 62995869
Hepatic cytolysis 13.24 10.35 67 487729 15340 62985886
Oligoarthritis 13.24 10.35 19 487777 552 63000674
Nasal obstruction 13.15 10.35 36 487760 1695 62999531
Colitis microscopic 13.12 10.35 33 487763 9306 62991920
Transaminases increased 13.12 10.35 166 487630 31201 62970025
Hypertransaminasaemia 13.10 10.35 19 487777 6590 62994636
Pulmonary alveolar haemorrhage 13.09 10.35 10 487786 4658 62996568
Haemodialysis 13.06 10.35 31 487765 8916 62992310
Hypertelorism 13.01 10.35 17 487779 451 63000775
Abdominal pain upper 12.97 10.35 1388 486408 205056 62796170
Motor dysfunction 12.92 10.35 41 487755 10720 62990506
Sleep disorder due to a general medical condition 12.91 10.35 49 487747 12139 62989087
Congenital cerebral cyst 12.89 10.35 13 487783 258 63000968
Lung transplant 12.86 10.35 4 487792 3124 62998102
Skin cancer 12.82 10.35 140 487656 11355 62989871
Tongue disorder 12.80 10.35 131 487665 10449 62990777
Oxygen consumption increased 12.69 10.35 7 487789 3877 62997349
Injection site haematoma 12.69 10.35 93 487703 6739 62994487
Embolism 12.68 10.35 26 487770 7880 62993346
Neonatal respiratory distress syndrome 12.67 10.35 49 487747 2769 62998457
Drug screen positive 12.67 10.35 6 487790 3623 62997603
Atrial flutter 12.62 10.35 36 487760 9736 62991490
Carotid artery thrombosis 12.56 10.35 3 487793 2791 62998435
Madarosis 12.56 10.35 4 487792 3077 62998149
Nail injury 12.54 10.35 20 487776 639 63000587
Lymphatic fistula 12.48 10.35 22 487774 764 63000462
Mental impairment 12.47 10.35 61 487735 14090 62987136
Cytomegalovirus viraemia 12.47 10.35 15 487781 5634 62995592
Foetal distress syndrome 12.41 10.35 30 487766 1308 62999918
Foetal death 12.37 10.35 134 487662 10846 62990380
Product physical issue 12.35 10.35 12 487784 4968 62996258
Incoherent 12.33 10.35 10 487786 4520 62996706
Hypoventilation 12.33 10.35 11 487785 4743 62996483
Human anti-human antibody test 12.25 10.35 16 487780 424 63000802
Nystagmus 12.21 10.35 18 487778 6202 62995024
Full blood count abnormal 12.12 10.35 171 487625 31546 62969680
Cervical incompetence 12.12 10.35 19 487777 598 63000628
Metastases to lymph nodes 12.12 10.35 28 487768 8130 62993096
X-ray abnormal 12.11 10.35 105 487691 8005 62993221
Post procedural haemorrhage 12.10 10.35 27 487769 7937 62993289
Pelvic pain 12.08 10.35 58 487738 13461 62987765
Foot operation 12.07 10.35 96 487700 7135 62994091
Atrial tachycardia 12 10.35 9 487787 4231 62996995
Personality change 12.00 10.35 22 487774 6951 62994275
Learning disorder 11.96 10.35 20 487776 665 63000561
Cholestasis of pregnancy 11.94 10.35 28 487768 1197 63000029
Occult blood 11.89 10.35 29 487767 1272 62999954
Seronegative arthritis 11.87 10.35 61 487735 3898 62997328
Induced labour 11.85 10.35 24 487772 927 63000299
Wrong product administered 11.84 10.35 18 487778 6123 62995103
Bone density increased 11.76 10.35 21 487775 737 63000489
Poor venous access 11.74 10.35 169 487627 14616 62986610
Cleft lip and palate 11.71 10.35 19 487777 616 63000610
Application site pain 11.68 10.35 9 487787 4173 62997053
Clostridium test positive 11.63 10.35 5 487791 3196 62998030
Hepatic necrosis 11.62 10.35 16 487780 5671 62995555
End stage renal disease 11.62 10.35 21 487775 6672 62994554
Off label use 11.59 10.35 4841 482955 669621 62331605
Autoimmune disorder 11.58 10.35 191 487605 16986 62984240
Facial paralysis 11.54 10.35 62 487734 13979 62987247
Post-traumatic stress disorder 11.53 10.35 14 487782 5237 62995989
Syndactyly 11.51 10.35 16 487780 451 63000775
Eye pruritus 11.50 10.35 90 487706 18581 62982645
Wound infection pseudomonas 11.50 10.35 29 487767 1299 62999927
Heart rate increased 11.50 10.35 599 487197 93639 62907587
Nephropathy toxic 11.47 10.35 36 487760 9443 62991783
Ataxia 11.46 10.35 69 487727 15126 62986100
Diabetes insipidus 11.45 10.35 3 487793 2622 62998604
Femoral hernia incarcerated 11.42 10.35 22 487774 819 63000407
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.41 10.35 4 487792 2895 62998331
Joint warmth 11.37 10.35 31 487765 1456 62999770
Oropharyngeal pain 11.36 10.35 858 486938 93629 62907597
Electrolyte imbalance 11.35 10.35 99 487697 19977 62981249
Pneumonia 11.35 10.35 3232 484564 453535 62547691
Brain natriuretic peptide increased 11.34 10.35 14 487782 5199 62996027
Dermatitis acneiform 11.31 10.35 13 487783 4983 62996243
Colorectal cancer 11.30 10.35 7 487789 3638 62997588
Forceps delivery 11.29 10.35 11 487785 209 63001017
Glomerular filtration rate decreased 11.24 10.35 59 487737 13382 62987844
Blood pressure inadequately controlled 11.22 10.35 13 487783 4965 62996261
Abortion incomplete 11.20 10.35 5 487791 3126 62998100
Threatened labour 11.18 10.35 22 487774 832 63000394
Cartilage injury 11.13 10.35 37 487759 1940 62999286
Pneumonia viral 11.13 10.35 28 487768 7894 62993332
Hypoglycaemic coma 11.13 10.35 3 487793 2572 62998654
Ventricular extrasystoles 11.12 10.35 49 487747 11638 62989588
Tendon disorder 11.11 10.35 80 487716 5763 62995463
Ligament rupture 11.09 10.35 54 487742 3376 62997850
Immunosuppression 11.08 10.35 110 487686 8704 62992522
Staphylococcal infection 11.07 10.35 237 487559 41019 62960207
Joint lock 11.07 10.35 41 487755 2270 62998956
Chronic graft versus host disease 11.03 10.35 5 487791 3097 62998129
Lipase increased 11.01 10.35 39 487757 9861 62991365
Iritis 11.01 10.35 51 487745 3124 62998102
Endophthalmitis 11.00 10.35 7 487789 3585 62997641
Coronary arterial stent insertion 10.97 10.35 4 487792 2825 62998401
Skin toxicity 10.96 10.35 12 487784 4702 62996524
Hyperthermia 10.92 10.35 35 487761 9121 62992105
Electrocardiogram QRS complex prolonged 10.88 10.35 18 487778 5920 62995306
Adenovirus infection 10.88 10.35 7 487789 3564 62997662
Temperature intolerance 10.87 10.35 34 487762 8930 62992296
Sickle cell anaemia 10.82 10.35 17 487779 536 63000690
Mucosal inflammation 10.80 10.35 276 487520 46652 62954574
Anterior chamber cleavage syndrome 10.79 10.35 10 487786 178 63001048
Blood lactic acid increased 10.79 10.35 24 487772 7062 62994164
Activated partial thromboplastin time prolonged 10.78 10.35 23 487773 6870 62994356
Immunodeficiency 10.77 10.35 217 487579 20037 62981189
Hypocalcaemia 10.74 10.35 175 487621 31538 62969688
Osteoporotic fracture 10.73 10.35 57 487739 3689 62997537
Exercise tolerance decreased 10.71 10.35 16 487780 5481 62995745
Lacrimation increased 10.69 10.35 104 487692 20527 62980699
Knee operation 10.68 10.35 81 487715 5932 62995294
Laboratory test abnormal 10.68 10.35 144 487652 26768 62974458
Epilepsy 10.67 10.35 145 487651 26920 62974306
Increased appetite 10.67 10.35 38 487758 9592 62991634
Blood iron increased 10.67 10.35 31 487765 1511 62999715
Chronic obstructive pulmonary disease 10.65 10.35 384 487412 62302 62938924
Oral herpes 10.62 10.35 269 487527 25805 62975421
Joint injury 10.59 10.35 300 487496 29272 62971954
C-reactive protein 10.57 10.35 69 487727 4813 62996413
Neuralgia 10.55 10.35 138 487658 25788 62975438
Nail operation 10.55 10.35 22 487774 868 63000358
Neutrophilia 10.49 10.35 11 487785 4395 62996831
Rales 10.47 10.35 56 487740 12641 62988585
Thirst 10.47 10.35 64 487732 13977 62987249
Abortion missed 10.43 10.35 33 487763 1686 62999540
Finger deformity 10.40 10.35 98 487698 7647 62993579
Abortion threatened 10.39 10.35 17 487779 555 63000671
Retrognathia 10.37 10.35 15 487781 439 63000787

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 636.97 10.28 823 156842 37415 34761851
Foetal exposure during pregnancy 327.65 10.28 604 157061 37497 34761769
Drug abuse 313.36 10.28 39 157626 99057 34700209
Arthralgia 271.51 10.28 1495 156170 168546 34630720
Toxicity to various agents 259.93 10.28 313 157352 200049 34599217
Completed suicide 224.59 10.28 81 157584 98087 34701179
Psoriatic arthropathy 208.11 10.28 343 157322 19455 34779811
Sickle cell anaemia with crisis 159.28 10.28 138 157527 3915 34795351
Joint swelling 154.14 10.28 606 157059 59284 34739982
Dysmorphism 143.73 10.28 117 157548 3039 34796227
Drug interaction 142.68 10.28 531 157134 225415 34573851
Musculoskeletal stiffness 114.99 10.28 466 157199 46214 34753052
Premature baby 114.13 10.28 265 157400 19368 34779898
Blood pressure fluctuation 100.73 10.28 296 157369 24953 34774313
Synovitis 100.12 10.28 206 157459 13860 34785406
Psoriasis 97.61 10.28 390 157275 38422 34760844
Enthesopathy 95.68 10.28 111 157554 4502 34794764
Intentional overdose 91.71 10.28 41 157624 43633 34755633
Exposure during pregnancy 88.81 10.28 151 157514 8783 34790483
Tenosynovitis 88.22 10.28 106 157559 4464 34794802
Pain 85.68 10.28 1347 156318 203328 34595938
C-reactive protein abnormal 84.99 10.28 146 157519 8564 34790702
Acute kidney injury 82.17 10.28 930 156735 304058 34495208
Speech disorder developmental 80.63 10.28 72 157593 2128 34797138
Death 76.76 10.28 1299 156366 396750 34402516
Arthropathy 73.04 10.28 277 157388 26630 34772636
Blood pressure systolic increased 71.38 10.28 247 157418 22705 34776561
Neonatal respiratory distress syndrome 70.50 10.28 89 157576 3945 34795321
Maternal exposure during pregnancy 68.32 10.28 97 157568 4821 34794445
Foetal anticonvulsant syndrome 67.07 10.28 50 157615 1137 34798129
Arthritis 66.41 10.28 299 157366 31047 34768219
Atrial septal defect 65.78 10.28 119 157546 7273 34791993
Hypospadias 64.68 10.28 76 157589 3125 34796141
Alanine aminotransferase abnormal 64.44 10.28 92 157573 4596 34794670
Low birth weight baby 63.76 10.28 122 157543 7783 34791483
Nasopharyngitis 62.09 10.28 533 157132 69435 34729831
Product use in unapproved indication 61.15 10.28 297 157368 117202 34682064
Coma 60.52 10.28 70 157595 45608 34753658
Maternal drugs affecting foetus 57.75 10.28 80 157585 3885 34795381
Drug reaction with eosinophilia and systemic symptoms 57.68 10.28 39 157626 32973 34766293
Autism spectrum disorder 57.54 10.28 61 157604 2235 34797031
Disease progression 56.92 10.28 272 157393 107805 34691461
Suicide attempt 56.21 10.28 56 157609 39060 34760206
Cryptorchism 56.14 10.28 57 157608 1984 34797282
Overdose 56.02 10.28 216 157449 90843 34708423
Rhabdomyolysis 55.84 10.28 142 157523 68021 34731245
Serotonin syndrome 55.81 10.28 11 157654 19922 34779344
Learning disorder 55.14 10.28 43 157622 1048 34798218
Small for dates baby 53.88 10.28 77 157588 3850 34795416
Hypoglycaemia neonatal 52.12 10.28 53 157612 1848 34797418
Blood pressure systolic abnormal 52.11 10.28 76 157589 3872 34795394
Hepatic function abnormal 51.54 10.28 75 157590 44288 34754978
Rheumatoid nodule 51.47 10.28 65 157600 2882 34796384
Tongue disorder 51.44 10.28 89 157576 5250 34794016
Palmar-plantar erythrodysaesthesia syndrome 49.78 10.28 8 157657 16787 34782479
Infusion related reaction 49.08 10.28 408 157257 52649 34746617
Pain in extremity 48.87 10.28 822 156843 125691 34673575
Ventricular septal defect 48.48 10.28 74 157591 3927 34795339
Maternal exposure during breast feeding 47.89 10.28 46 157619 1495 34797771
Blood pressure diastolic abnormal 47.32 10.28 81 157584 4737 34794529
Heart rate decreased 47.07 10.28 274 157391 31471 34767795
Osteoarthritis 46.83 10.28 201 157464 20441 34778825
Blood pressure increased 45.99 10.28 603 157062 87499 34711767
Lower respiratory tract infection 45.57 10.28 271 157394 31366 34767900
Syndactyly 45.23 10.28 35 157630 843 34798423
Drug intolerance 44.82 10.28 438 157227 59132 34740134
Blood pressure diastolic decreased 44.59 10.28 115 157550 8979 34790287
Drug dependence 44.51 10.28 27 157638 24190 34775076
Hand deformity 43.88 10.28 68 157597 3657 34795609
Developmental delay 43.46 10.28 58 157607 2717 34796549
Pancytopenia 43.07 10.28 635 157030 94522 34704744
Joint effusion 42.94 10.28 81 157584 5112 34794154
Foot deformity 42.89 10.28 75 157590 4462 34794804
Bradycardia 42.56 10.28 185 157480 75233 34724033
Pulmonary fibrosis 42.41 10.28 180 157485 18216 34781050
Febrile neutropenia 41.72 10.28 405 157260 136444 34662822
Tendonitis 41.18 10.28 112 157553 9028 34790238
Drug resistance 40.96 10.28 34 157631 25893 34773373
Angioedema 40.71 10.28 66 157599 37308 34761958
Somnolence 40.47 10.28 314 157351 110802 34688464
C-reactive protein increased 40.32 10.28 397 157268 53701 34745565
Suicidal ideation 39.76 10.28 76 157589 40312 34758954
Talipes 39.42 10.28 46 157619 1877 34797389
Exposure via breast milk 39.42 10.28 47 157618 1963 34797303
Multiple organ dysfunction syndrome 38.96 10.28 195 157470 76371 34722895
Peripheral swelling 38.75 10.28 521 157144 76020 34723246
Grip strength decreased 37.54 10.28 58 157607 3111 34796155
Joint laxity 36.73 10.28 23 157642 389 34798877
Basal cell carcinoma 36.15 10.28 180 157485 19478 34779788
Intentional product misuse 35.83 10.28 97 157568 45514 34753752
Knee arthroplasty 35.34 10.28 93 157572 7351 34791915
Red blood cell sedimentation rate increased 35.19 10.28 106 157559 9056 34790210
Respiratory arrest 35.00 10.28 45 157620 27998 34771268
Renal failure 34.67 10.28 399 157266 130158 34669108
Cytomegalovirus infection 34.67 10.28 40 157625 26095 34773171
Delirium 34.22 10.28 94 157571 43897 34755369
Congenital hand malformation 33.48 10.28 25 157640 570 34798696
Inflammation 33.13 10.28 230 157435 28065 34771201
Plagiocephaly 33.03 10.28 24 157641 524 34798742
Polyarthritis 32.91 10.28 67 157598 4473 34794793
Psychotic disorder 32.89 10.28 37 157628 24415 34774851
Foetal growth restriction 32.54 10.28 63 157602 4054 34795212
Jaundice neonatal 32.39 10.28 35 157630 1311 34797955
Caesarean section 32.02 10.28 44 157621 2120 34797146
Hypermobility syndrome 31.59 10.28 20 157645 345 34798921
Body temperature decreased 31.18 10.28 129 157536 12905 34786361
Intellectual disability 30.82 10.28 34 157631 1304 34797962
Finger deformity 30.70 10.28 36 157629 1477 34797789
Language disorder 30.61 10.28 44 157621 2212 34797054
Altered state of consciousness 30.40 10.28 35 157630 22858 34776408
Lactic acidosis 30.39 10.28 70 157595 34702 34764564
Sedation 30.26 10.28 30 157635 20976 34778290
Acute chest syndrome 30.18 10.28 27 157638 800 34798466
Cardiac failure 29.97 10.28 265 157400 90983 34708283
Anal fistula 29.34 10.28 71 157594 5328 34793938
Astigmatism 29.02 10.28 30 157635 1067 34798199
Dysgraphia 28.71 10.28 43 157622 2244 34797022
Haemoglobin decreased 28.56 10.28 730 156935 120042 34679224
Weight decreased 28.32 10.28 1016 156649 175285 34623981
Poisoning 28.08 10.28 10 157655 12216 34787050
Hyperglycaemia 28.07 10.28 88 157577 39392 34759874
Drug withdrawal syndrome 27.80 10.28 29 157636 19805 34779461
Large for dates baby 27.77 10.28 27 157638 891 34798375
Depressed level of consciousness 27.38 10.28 100 157565 42741 34756525
Hypotonia neonatal 27.28 10.28 32 157633 1313 34797953
Tuberculosis 27.27 10.28 93 157572 8484 34790782
Blood pressure diastolic increased 27.22 10.28 66 157599 4959 34794307
Hydrops foetalis 27.17 10.28 26 157639 841 34798425
Cardiac arrest 27.05 10.28 290 157375 95869 34703397
Musculoskeletal pain 27.03 10.28 241 157424 31722 34767544
Diaphragmatic disorder 26.98 10.28 31 157634 1244 34798022
Drug withdrawal syndrome neonatal 26.93 10.28 54 157611 3565 34795701
Toxic epidermal necrolysis 26.74 10.28 35 157630 21611 34777655
Ankylosing spondylitis 26.59 10.28 70 157595 5534 34793732
Wound 26.55 10.28 135 157530 14729 34784537
Ultrasound antenatal screen 26.14 10.28 21 157644 535 34798731
Selective eating disorder 26.08 10.28 36 157629 1742 34797524
Appendicolith 25.71 10.28 4 157661 8597 34790669
Hyperbilirubinaemia neonatal 25.55 10.28 24 157641 758 34798508
Therapeutic product effect decreased 25.41 10.28 254 157411 34489 34764777
Nasal disorder 25.28 10.28 37 157628 1891 34797375
Pathogen resistance 24.99 10.28 6 157659 9476 34789790
Loss of personal independence in daily activities 24.97 10.28 244 157421 32935 34766331
Agitation 24.93 10.28 154 157511 57245 34742021
Motor developmental delay 24.75 10.28 22 157643 646 34798620
Knee deformity 24.75 10.28 22 157643 646 34798620
Serum ferritin increased 24.45 10.28 72 157593 6074 34793192
Radiation inflammation 24.39 10.28 25 157640 880 34798386
Colitis ulcerative 24.10 10.28 142 157523 16378 34782888
Acute hepatic failure 24.09 10.28 17 157648 14057 34785209
Hypoglycaemia 24.04 10.28 146 157519 54494 34744772
Anal fissure 23.94 10.28 57 157608 4233 34795033
Trisomy 18 23.93 10.28 23 157642 748 34798518
Skin cancer 23.92 10.28 101 157564 10196 34789070
Dyspraxia 23.79 10.28 18 157647 419 34798847
Lung neoplasm malignant 23.77 10.28 147 157518 17248 34782018
Constipation 23.72 10.28 455 157210 136527 34662739
Localised infection 23.64 10.28 148 157517 17439 34781827
Vitamin D deficiency 23.11 10.28 74 157591 6534 34792732
Joint range of motion decreased 23.00 10.28 79 157586 7233 34792033
Poor venous access 22.84 10.28 63 157602 5120 34794146
Urticaria 22.82 10.28 176 157489 62201 34737065
Infection 22.81 10.28 554 157111 90361 34708905
Foetal disorder 22.59 10.28 23 157642 803 34798463
Joint stiffness 22.49 10.28 103 157562 10770 34788496
Cleft lip and palate 22.45 10.28 24 157641 888 34798378
Respiratory disorder neonatal 22.42 10.28 32 157633 1598 34797668
Strabismus 22.38 10.28 33 157632 1698 34797568
Blood creatine phosphokinase increased 22.38 10.28 115 157550 44742 34754524
Neuroleptic malignant syndrome 22.15 10.28 29 157636 17905 34781361
Cardiogenic shock 22.13 10.28 55 157610 26563 34772703
Red blood cell sedimentation rate 22.02 10.28 27 157638 1161 34798105
Oropharyngeal pain 22.02 10.28 251 157414 35234 34764032
Substance abuse 21.85 10.28 4 157661 7637 34791629
Intentional self-injury 21.82 10.28 18 157647 13753 34785513
Hepatic failure 21.81 10.28 81 157584 34450 34764816
Blood parathyroid hormone decreased 21.76 10.28 30 157635 1450 34797816
Hydrocele 21.71 10.28 36 157629 2051 34797215
Shock 21.68 10.28 48 157617 24131 34775135
Otitis media 21.55 10.28 43 157622 2829 34796437
Juvenile idiopathic arthritis 21.47 10.28 34 157631 1863 34797403
Arthritis bacterial 21.45 10.28 61 157604 5045 34794221
Congenital foot malformation 21.43 10.28 17 157648 425 34798841
Dyslexia 20.98 10.28 15 157650 319 34798947
Renal impairment 20.94 10.28 300 157365 94213 34705053
Agitation neonatal 20.47 10.28 25 157640 1071 34798195
Granuloma skin 20.44 10.28 27 157638 1252 34798014
Gastrointestinal infection 20.34 10.28 65 157600 5733 34793533
Crohn's disease 20.26 10.28 44 157621 3073 34796193
Oxygen saturation decreased 20.13 10.28 348 157317 53470 34745796
Medical device implantation 20.05 10.28 19 157646 607 34798659
Behaviour disorder 19.99 10.28 58 157607 4852 34794414
Hallucination 19.93 10.28 143 157522 51355 34747911
Umbilical hernia 19.77 10.28 56 157609 4621 34794645
Multiple congenital abnormalities 19.77 10.28 18 157647 546 34798720
Arthritis infective 19.70 10.28 46 157619 3373 34795893
Haematochezia 19.67 10.28 307 157358 46227 34753039
Respiratory failure 19.61 10.28 358 157307 108214 34691052
Anaphylactic shock 19.46 10.28 26 157639 15915 34783351
Malignant melanoma 19.30 10.28 80 157585 8010 34791256
Haematocrit decreased 19.15 10.28 226 157439 31990 34767276
Rash maculo-papular 19.12 10.28 65 157600 28386 34770880
Spinal disorder 19.05 10.28 52 157613 4200 34795066
Joint ankylosis 18.94 10.28 29 157636 1543 34797723
Attention deficit hyperactivity disorder 18.83 10.28 38 157627 2521 34796745
C-reactive protein decreased 18.80 10.28 33 157632 1969 34797297
Congenital anomaly 18.65 10.28 27 157638 1366 34797900
Lacrimal disorder 18.64 10.28 14 157651 322 34798944
Cleft lip 18.61 10.28 14 157651 323 34798943
No adverse event 18.58 10.28 48 157617 22879 34776387
Renal aplasia 18.58 10.28 20 157645 746 34798520
Diabetic ketoacidosis 18.57 10.28 33 157632 17999 34781267
Weight decrease neonatal 18.53 10.28 14 157651 325 34798941
Infective pulmonary exacerbation of cystic fibrosis 18.53 10.28 4 157661 6797 34792469
Post procedural infection 18.48 10.28 56 157609 4800 34794466
Congenital bladder anomaly 18.45 10.28 13 157652 270 34798996
Incorrect route of product administration 18.34 10.28 24 157641 14821 34784445
Limb reduction defect 18.12 10.28 13 157652 278 34798988
Anti-cyclic citrullinated peptide antibody positive 18.12 10.28 31 157634 1812 34797454
Patent ductus arteriosus 18.11 10.28 44 157621 3310 34795956
Vomiting 18.01 10.28 923 156742 246698 34552568
Ankyloglossia congenital 17.88 10.28 13 157652 284 34798982
Pectus excavatum 17.86 10.28 12 157653 230 34799036
Immunodeficiency 17.82 10.28 60 157605 5438 34793828
Respiratory rate increased 17.77 10.28 90 157575 9804 34789462
Cytokine release syndrome 17.70 10.28 49 157616 22828 34776438
Scoliosis 17.67 10.28 39 157626 2754 34796512
Microcephaly 17.64 10.28 20 157645 791 34798475
Neurotoxicity 17.63 10.28 34 157631 17976 34781290
Nodule 17.52 10.28 69 157596 6750 34792516
Venoocclusive liver disease 17.48 10.28 7 157658 7959 34791307
Skin injury 17.46 10.28 35 157630 2310 34796956
Ear disorder 17.37 10.28 29 157636 1661 34797605
Hepatic enzyme increased 17.35 10.28 260 157405 38820 34760446
Bone cyst 17.18 10.28 28 157637 1572 34797694
Haemangioma congenital 17.12 10.28 16 157649 502 34798764
Mobility decreased 16.88 10.28 209 157456 29919 34769347
Vitamin B12 deficiency 16.78 10.28 48 157617 3983 34795283
Arthrodesis 16.69 10.28 15 157650 447 34798819
Electrocardiogram QT prolonged 16.69 10.28 112 157553 40840 34758426
Pyrexia 16.64 10.28 1285 156380 331728 34467538
Weight increased 16.64 10.28 543 157122 92490 34706776
Off label use 16.53 10.28 1649 156016 417875 34381391
Heart rate irregular 16.49 10.28 125 157540 15682 34783584
Abortion spontaneous 16.49 10.28 14 157651 386 34798880
Respiratory depression 16.49 10.28 30 157635 16215 34783051
Fistula discharge 16.48 10.28 20 157645 851 34798415
Bronchiolitis 16.44 10.28 41 157624 3135 34796131
Malignant neoplasm progression 16.31 10.28 289 157376 87757 34711509
Synovial cyst 16.29 10.28 34 157631 2310 34796956
Ear infection 16.27 10.28 90 157575 10141 34789125
Latent tuberculosis 16.22 10.28 25 157640 1338 34797928
Bradycardia neonatal 16.22 10.28 21 157644 955 34798311
Haemangioma 16.19 10.28 30 157635 1867 34797399
Red blood cell sedimentation rate abnormal 16.19 10.28 44 157621 3545 34795721
Cerebral haemorrhage 16.08 10.28 92 157573 34845 34764421
Drug ineffective for unapproved indication 16.06 10.28 54 157611 23661 34775605
Back disorder 16.05 10.28 66 157599 6585 34792681
Unresponsive to stimuli 15.92 10.28 67 157598 27502 34771764
Arnold-Chiari malformation 15.86 10.28 13 157652 341 34798925
Respiratory tract infection viral 15.76 10.28 35 157630 2482 34796784
Foetal distress syndrome 15.73 10.28 22 157643 1078 34798188
Psychomotor retardation 15.72 10.28 44 157621 3606 34795660
Neck mass 15.68 10.28 27 157638 1586 34797680
Aggression 15.66 10.28 107 157558 38857 34760409
Oesophageal fibrosis 15.62 10.28 10 157655 176 34799090
Hypertelorism 15.55 10.28 16 157649 566 34798700
Inguinal hernia 15.52 10.28 72 157593 7569 34791697
Polydactyly 15.50 10.28 23 157642 1190 34798076
Tooth malformation 15.38 10.28 10 157655 181 34799085
Septic arthritis staphylococcal 15.28 10.28 15 157650 501 34798765
Foetal heart rate deceleration abnormality 15.16 10.28 15 157650 506 34798760
Panniculitis 15.14 10.28 30 157635 1964 34797302
Proteinuria 15.13 10.28 39 157626 18603 34780663
Product quality issue 15.12 10.28 34 157631 17001 34782265
Maternal exposure timing unspecified 14.97 10.28 13 157652 370 34798896
Aspergillus infection 14.94 10.28 20 157645 12234 34787032
Developmental coordination disorder 14.91 10.28 10 157655 191 34799075
Autoscopy 14.91 10.28 11 157654 246 34799020
Maternal exposure before pregnancy 14.70 10.28 18 157647 773 34798493
Dry mouth 14.67 10.28 78 157587 30087 34769179
Pleuritic pain 14.58 10.28 42 157623 3499 34795767
Hepatitis E antibody positive 14.54 10.28 11 157654 256 34799010
Ventricular fibrillation 14.39 10.28 54 157611 22900 34776366
Wrong technique in product usage process 14.38 10.28 99 157566 35887 34763379
Stevens-Johnson syndrome 14.36 10.28 40 157625 18599 34780667
Tachycardia 14.23 10.28 283 157382 84489 34714777
Educational problem 14.20 10.28 15 157650 547 34798719
Hypoxia 13.98 10.28 170 157495 54925 34744341
Cardiac murmur 13.87 10.28 71 157594 7766 34791500
Vascular insufficiency 13.80 10.28 12 157653 342 34798924
Obsessive-compulsive disorder 13.75 10.28 4 157661 5560 34793706
Rheumatoid lung 13.71 10.28 19 157646 923 34798343
Hernia pain 13.63 10.28 11 157654 282 34798984
Injection site haemorrhage 13.63 10.28 83 157582 9685 34789581
Blood insulin increased 13.63 10.28 12 157653 348 34798918
Abnormal behaviour 13.62 10.28 62 157603 24907 34774359
Akathisia 13.61 10.28 10 157655 8099 34791167
Fine motor skill dysfunction 13.54 10.28 27 157638 1775 34797491
Nephrolithiasis 13.54 10.28 202 157463 30131 34769135
Hypermetropia 13.49 10.28 14 157651 500 34798766
Anal atresia 13.47 10.28 11 157654 287 34798979
Hypertriglyceridaemia 13.44 10.28 11 157654 8437 34790829
Hepatitis E virus test positive 13.44 10.28 11 157654 288 34798978
Haemolysis 13.41 10.28 72 157593 8022 34791244
Metabolic acidosis 13.40 10.28 129 157536 43551 34755715
Spina bifida 13.37 10.28 12 157653 357 34798909
Cellulitis 13.37 10.28 323 157342 52628 34746638
Osteonecrosis of jaw 13.34 10.28 39 157626 17850 34781416
Ventricular tachycardia 13.33 10.28 68 157597 26511 34772755
Hyperammonaemia 13.32 10.28 6 157659 6361 34792905
Pleural fibrosis 13.29 10.28 23 157642 1357 34797909
Sexual dysfunction 13.10 10.28 6 157659 6297 34792969
Treatment failure 13.07 10.28 289 157376 46408 34752858
Irritability 13.06 10.28 62 157603 24628 34774638
Ear malformation 13.00 10.28 11 157654 302 34798964
Nail bed bleeding 12.99 10.28 12 157653 371 34798895
Nail pitting 12.94 10.28 11 157654 304 34798962
Blood test abnormal 12.93 10.28 64 157601 6907 34792359
Neutropenia neonatal 12.91 10.28 16 157649 696 34798570
Contraindicated product administered 12.90 10.28 151 157514 21330 34777936
Second primary malignancy 12.88 10.28 10 157655 7876 34791390
Cholelithiasis 12.85 10.28 149 157516 20999 34778267
Upper respiratory tract infection 12.81 10.28 215 157450 32844 34766422
Low set ears 12.72 10.28 13 157652 456 34798810
BK virus infection 12.66 10.28 5 157660 5733 34793533
Withdrawal syndrome 12.64 10.28 23 157642 12432 34786834
Osteolysis 12.64 10.28 37 157628 3111 34796155
Adenovirus infection 12.59 10.28 4 157661 5253 34794013
Pulmonary pain 12.58 10.28 21 157644 1203 34798063
Drug level increased 12.58 10.28 54 157611 22042 34777224
Gangrene neonatal 12.57 10.28 9 157656 192 34799074
Congenital hydronephrosis 12.54 10.28 16 157649 717 34798549
Palindromic rheumatism 12.52 10.28 9 157656 193 34799073
Suspected suicide 12.52 10.28 3 157662 4745 34794521
Vitamin B complex deficiency 12.49 10.28 12 157653 390 34798876
Cystitis haemorrhagic 12.45 10.28 5 157660 5674 34793592
Cholestasis 12.38 10.28 71 157594 26877 34772389
Myopia 12.36 10.28 20 157645 1116 34798150
Gross motor delay 12.32 10.28 11 157654 325 34798941
Bone erosion 12.30 10.28 43 157622 3972 34795294
Excessive cerumen production 12.26 10.28 11 157654 327 34798939
Fistula 12.13 10.28 62 157603 6778 34792488
Neonatal infection 12.12 10.28 12 157653 405 34798861
Pharyngitis 12.05 10.28 69 157596 7875 34791391
Pulmonary artery stenosis congenital 12.01 10.28 13 157652 488 34798778
Neonatal seizure 11.94 10.28 13 157652 491 34798775
Pharyngeal disorder 11.93 10.28 16 157649 753 34798513
Agranulocytosis 11.92 10.28 61 157604 23760 34775506
Congenital genital malformation 11.79 10.28 8 157657 156 34799110
Hypokalaemia 11.78 10.28 188 157477 58026 34741240
Mouth ulceration 11.77 10.28 93 157572 11817 34787449
Peripheral artery thrombosis 11.73 10.28 30 157635 2330 34796936
Meningeal disorder 11.70 10.28 11 157654 348 34798918
Non-Hodgkin's lymphoma 11.64 10.28 23 157642 1502 34797764
Paranoia 11.62 10.28 23 157642 12045 34787221
Hypotension 11.56 10.28 852 156813 220797 34578469
Visuospatial deficit 11.51 10.28 7 157658 112 34799154
Tooth injury 11.49 10.28 20 157645 1185 34798081
Emphysema 11.49 10.28 78 157587 9447 34789819
Gastroschisis 11.40 10.28 8 157657 165 34799101
Neck pain 11.39 10.28 169 157496 25180 34774086
End stage renal disease 11.28 10.28 14 157651 8847 34790419
General physical health deterioration 11.24 10.28 696 156969 127573 34671693
Kyphosis 11.13 10.28 20 157645 1216 34798050
Kidney infection 11.08 10.28 51 157614 5343 34793923
Foetal hypokinesia 11.07 10.28 11 157654 373 34798893
Myoclonus 11.05 10.28 32 157633 14693 34784573
Hepatic encephalopathy 10.96 10.28 32 157633 14653 34784613
Acute graft versus host disease 10.94 10.28 8 157657 6495 34792771
Cleft palate 10.91 10.28 14 157651 631 34798635
Bronchopulmonary aspergillosis 10.90 10.28 32 157633 14627 34784639
Encopresis 10.88 10.28 8 157657 178 34799088
Pancreatic duct stenosis 10.84 10.28 8 157657 179 34799087
Disseminated intravascular coagulation 10.84 10.28 56 157609 21760 34777506
Steatorrhoea 10.83 10.28 15 157650 728 34798538
Scrotal infection 10.77 10.28 14 157651 639 34798627
Live birth 10.76 10.28 9 157656 243 34799023
Diverticulum 10.74 10.28 62 157603 7097 34792169
Fracture 10.73 10.28 60 157605 6789 34792477
Diverticular perforation 10.71 10.28 37 157628 3397 34795869
Tuberculin test positive 10.65 10.28 19 157646 1148 34798118
Ulna fracture 10.62 10.28 11 157654 392 34798874
Sinusitis 10.59 10.28 253 157412 41149 34758117
Transient aphasia 10.58 10.28 11 157654 394 34798872
Acute generalised exanthematous pustulosis 10.56 10.28 9 157656 6767 34792499
Condition aggravated 10.53 10.28 1005 156660 191191 34608075
Pulmonary alveolar haemorrhage 10.51 10.28 11 157654 7501 34791765
Cerebral ventricle dilatation 10.50 10.28 17 157648 949 34798317
Skin lesion 10.49 10.28 148 157517 21813 34777453
Injection site bruising 10.48 10.28 71 157594 8592 34790674
Nose deformity 10.47 10.28 8 157657 189 34799077
Muscle twitching 10.47 10.28 19 157646 10279 34788987
Blood lactic acid increased 10.41 10.28 9 157656 6719 34792547
Brain oedema 10.40 10.28 30 157635 13791 34785475
Swollen joint count increased 10.40 10.28 9 157656 255 34799011
Hepatitis fulminant 10.38 10.28 3 157662 4187 34795079
Abdominal discomfort 10.37 10.28 348 157317 59487 34739779
Disability assessment scale score increased 10.34 10.28 9 157656 257 34799009
Dysstasia 10.33 10.28 92 157573 12103 34787163
Lung neoplasm 10.32 10.28 45 157620 4606 34794660

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1415.53 9.95 3603 485141 204867 79050777
Arthropathy 1124.74 9.95 2986 485758 174125 79081519
Systemic lupus erythematosus 1101.53 9.95 2349 486395 118800 79136844
Pemphigus 1100.15 9.95 2094 486650 97488 79158156
Joint swelling 1092.23 9.95 4066 484678 284580 78971064
Hand deformity 1070.98 9.95 2122 486622 101797 79153847
Synovitis 1067.31 9.95 2648 486096 148086 79107558
Completed suicide 1037.97 9.95 139 488605 245628 79010016
Glossodynia 958.20 9.95 2020 486724 101317 79154327
Toxicity to various agents 910.62 9.95 749 487995 420791 78834853
Arthralgia 852.56 9.95 6206 482538 565597 78690047
Anti-cyclic citrullinated peptide antibody positive 825.63 9.95 1672 487072 81471 79174173
Wound 801.12 9.95 2021 486723 114158 79141486
Maternal exposure during pregnancy 774.96 9.95 2210 486534 134328 79121316
Infusion related reaction 767.32 9.95 3117 485627 227120 79028524
Pericarditis 745.72 9.95 1839 486905 102397 79153247
Drug abuse 674.92 9.95 97 488647 162594 79093050
Abdominal discomfort 654.69 9.95 3156 485588 247571 79008073
Pain 621.05 9.95 6813 481931 696989 78558655
Therapeutic product effect decreased 611.85 9.95 2300 486444 161563 79094081
Discomfort 603.97 9.95 1918 486826 123699 79131945
Swelling 595.61 9.95 2769 485975 213942 79041702
Alopecia 593 9.95 2897 485847 228458 79027186
Contraindicated product administered 562.44 9.95 2180 486564 155358 79100286
Duodenal ulcer perforation 526.09 9.95 1217 487527 64994 79190650
Helicobacter infection 522.09 9.95 1252 487492 68452 79187192
Drug intolerance 508.73 9.95 3059 485685 261060 78994584
Musculoskeletal stiffness 505.12 9.95 2269 486475 172739 79082905
Rheumatoid factor positive 502.19 9.95 1124 487620 58715 79196929
Drug interaction 488.06 9.95 1144 487600 414039 78841605
Death 466.45 9.95 1840 486904 564674 78690970
Hepatic enzyme increased 465.81 9.95 2284 486460 180326 79075318
Nasopharyngitis 458.38 9.95 2892 485852 250989 79004655
Psoriatic arthropathy 428.22 9.95 1248 487496 76751 79178893
Intentional overdose 372.12 9.95 95 488649 105865 79149779
Exposure during pregnancy 371.00 9.95 1412 487332 99720 79155924
Acute kidney injury 353.36 9.95 1810 486934 517594 78738050
Impaired healing 339.97 9.95 1246 487498 86409 79169235
Treatment failure 321.18 9.95 1964 486780 168522 79087122
Febrile neutropenia 315.33 9.95 584 488160 230415 79025229
Hypersensitivity 309.57 9.95 2701 486043 259538 78996106
C-reactive protein abnormal 299.92 9.95 809 487935 47558 79208086
Muscle injury 296.86 9.95 808 487936 47753 79207891
Lower respiratory tract infection 294.89 9.95 1567 487177 127653 79127991
Folliculitis 293.33 9.95 875 487869 54505 79201139
Irritable bowel syndrome 282.34 9.95 932 487812 61309 79194335
Product use issue 281.16 9.95 2224 486520 207598 79048046
Peripheral swelling 275.32 9.95 2692 486052 266925 78988719
Sinusitis 272.89 9.95 2092 486652 193409 79062235
Blister 268.63 9.95 1443 487301 118033 79137611
Sleep disorder due to general medical condition, insomnia type 261.54 9.95 720 488024 42836 79212808
Cardiac arrest 256.83 9.95 411 488333 171685 79083959
Red blood cell sedimentation rate abnormal 247.68 9.95 454 488290 20509 79235135
Knee arthroplasty 236.35 9.95 691 488053 42557 79213087
Arthritis 235.92 9.95 1354 487390 113526 79142118
Depressed level of consciousness 232.45 9.95 153 488591 96499 79159145
Sickle cell anaemia with crisis 231.63 9.95 264 488480 7658 79247986
Overdose 229.58 9.95 491 488253 183715 79071929
Suicide attempt 225.53 9.95 113 488631 82819 79172825
Blood pressure fluctuation 225.53 9.95 912 487832 66233 79189411
Disease progression 223.51 9.95 499 488245 183863 79071781
Osteoarthritis 218.08 9.95 1086 487658 86223 79169421
Hip arthroplasty 217.60 9.95 594 488150 35162 79220482
Weight increased 217.15 9.95 2627 486117 274759 78980885
Bradycardia 208.65 9.95 317 488427 135240 79120404
Rhabdomyolysis 194.19 9.95 207 488537 102924 79152720
Rheumatic fever 194.07 9.95 494 488250 28031 79227613
Infection 182.56 9.95 2274 486470 239438 79016206
Drug reaction with eosinophilia and systemic symptoms 181.62 9.95 83 488661 64161 79191483
Fibromyalgia 180.01 9.95 827 487917 63513 79192131
Sedation 179.36 9.95 48 488696 51847 79203797
Malignant neoplasm progression 174.86 9.95 356 488388 135634 79120010
Constipation 174.14 9.95 1019 487725 282031 78973613
Renal failure 173.07 9.95 640 488104 200328 79055316
Respiratory arrest 169.60 9.95 70 488674 57480 79198164
Ill-defined disorder 167.76 9.95 824 487920 65051 79190593
Lactic acidosis 165.66 9.95 114 488630 70245 79185399
Blood pressure systolic increased 164.99 9.95 830 487914 66156 79189488
Condition aggravated 164.76 9.95 4127 484617 496997 78758647
Swollen joint count increased 162.19 9.95 403 488341 22524 79233120
Red blood cell sedimentation rate increased 161.48 9.95 633 488111 45309 79210335
Blood pressure systolic abnormal 157.17 9.95 335 488409 16912 79238732
Cardiac failure 155.40 9.95 461 488283 154381 79101263
Blood pressure diastolic abnormal 154.70 9.95 355 488389 18847 79236797
Neutropenia 151.42 9.95 1086 487658 286624 78969020
Contusion 150.45 9.95 1483 487261 147293 79108351
Pregnancy 147.64 9.95 430 488314 26421 79229223
Hyponatraemia 146.89 9.95 576 488168 177272 79078372
Hepatic function abnormal 145.30 9.95 140 488604 72967 79182677
Abortion spontaneous 144.81 9.95 454 488290 29053 79226591
Hypotension 143.05 9.95 1871 486873 438446 78817198
Serotonin syndrome 142.32 9.95 49 488695 44978 79210666
Sopor 140.80 9.95 18 488726 32992 79222652
Respiratory failure 138.76 9.95 603 488141 180308 79075336
Multiple organ dysfunction syndrome 138.02 9.95 335 488409 119911 79135733
Joint effusion 136.34 9.95 325 488419 17689 79237955
Somnolence 134.67 9.95 884 487860 238097 79017547
Drug ineffective 133.83 9.95 7990 480754 1072923 78182721
C-reactive protein increased 133.80 9.95 1293 487451 127734 79127910
Psoriasis 132.97 9.95 973 487771 88614 79167030
Inflammation 130.54 9.95 1003 487741 92750 79162894
Coma 128.94 9.95 264 488480 100385 79155259
Grip strength decreased 128.79 9.95 359 488385 21510 79234134
Agitation 128.21 9.95 261 488483 99454 79156190
Hypoglycaemia 121.42 9.95 277 488467 101317 79154327
Rash 121.38 9.95 4508 484236 573850 78681794
Drug resistance 120.16 9.95 54 488690 42159 79213485
Intentional product use issue 119.92 9.95 1443 487301 150669 79104975
Stomatitis 119.13 9.95 1400 487344 145357 79110287
Blood pressure diastolic decreased 118.33 9.95 431 488313 29785 79225859
Hepatic failure 115.06 9.95 123 488621 61089 79194555
Drug dependence 114.72 9.95 53 488691 40716 79214928
Renal impairment 114.34 9.95 537 488207 157246 79098398
Electrocardiogram QT prolonged 112.48 9.95 241 488503 90145 79165499
Cardio-respiratory arrest 111.81 9.95 319 488425 108191 79147453
Rheumatoid nodule 111.43 9.95 295 488449 17143 79238501
Enthesopathy 111.05 9.95 230 488514 11378 79244266
Foot deformity 110.49 9.95 362 488382 23712 79231932
Fatigue 109.53 9.95 6844 481900 922883 78332761
Osteoporosis 109.21 9.95 635 488109 53477 79202167
Cytomegalovirus infection 108.77 9.95 63 488681 42581 79213063
Gastrointestinal disorder 107.84 9.95 1185 487559 121020 79134624
Hypoxia 106.76 9.95 303 488441 102940 79152704
Tachycardia 106.06 9.95 646 488098 177122 79078522
Hyperglycaemia 104.84 9.95 168 488576 70167 79185477
Pain in extremity 104.31 9.95 2949 485795 361589 78894055
Hyperhidrosis 102.61 9.95 528 488216 150964 79104680
Intentional product misuse 101.59 9.95 275 488469 94890 79160754
Blood cholesterol increased 101.55 9.95 868 487876 82852 79172792
Live birth 100.97 9.95 298 488446 18446 79237198
Heart rate decreased 100.52 9.95 757 487987 69559 79186085
Bone erosion 100.23 9.95 288 488456 17559 79238085
Intentional self-injury 99.53 9.95 37 488707 32382 79223262
Disability assessment scale score increased 99.01 9.95 114 488630 3344 79252300
Musculoskeletal pain 98.01 9.95 1009 487735 101345 79154299
Angioedema 97.75 9.95 199 488545 75836 79179808
Tenosynovitis 96.23 9.95 260 488484 15294 79240350
Neoplasm progression 95.86 9.95 105 488639 51577 79204067
Joint range of motion decreased 93.22 9.95 428 488316 32854 79222790
Neuropathy peripheral 93.18 9.95 497 488247 140808 79114836
Altered state of consciousness 92.94 9.95 79 488665 43743 79211901
Device expulsion 91.12 9.95 23 488721 25838 79229806
Juvenile idiopathic arthritis 90.40 9.95 128 488616 4635 79251009
Poisoning 89.97 9.95 22 488722 25250 79230394
Cardiac failure congestive 88.36 9.95 511 488233 141891 79113753
Thrombocytopenia 88.28 9.95 1121 487623 264138 78991506
Loss of personal independence in daily activities 87.89 9.95 989 487755 101591 79154053
Metabolic acidosis 87.71 9.95 239 488505 82290 79173354
Syncope 87.38 9.95 692 488052 178757 79076887
Injection site erythema 87.22 9.95 796 487948 77401 79178243
Joint stiffness 86.23 9.95 485 488259 40345 79215299
Palmar-plantar erythrodysaesthesia syndrome 84.43 9.95 49 488695 33085 79222559
Respiratory depression 84.04 9.95 32 488712 27598 79228046
Polyarthritis 83.70 9.95 212 488532 11990 79243654
Dehydration 82.90 9.95 1048 487696 247139 79008505
Pulmonary fibrosis 82.20 9.95 507 488237 43605 79212039
Drug withdrawal syndrome 82.05 9.95 56 488688 34662 79220982
Mobility decreased 81.90 9.95 1125 487619 121050 79134594
Disseminated intravascular coagulation 81.83 9.95 60 488684 35782 79219862
Joint destruction 81.23 9.95 137 488607 5788 79249856
Injection site pruritus 80.07 9.95 488 488256 41795 79213849
Anaemia 79.64 9.95 2097 486647 442918 78812726
Tremor 79.54 9.95 663 488081 169420 79086224
Cognitive disorder 79.29 9.95 196 488548 69730 79185914
Seizure 78.72 9.95 758 487986 188076 79067568
Cytokine release syndrome 78.69 9.95 63 488681 35935 79219709
Shock 78.02 9.95 91 488653 43457 79212187
Blood creatine phosphokinase increased 77.51 9.95 182 488562 65908 79189736
Hallucination 77.12 9.95 268 488476 85477 79170167
Caesarean section 76.01 9.95 208 488536 12327 79243317
Vomiting 74.12 9.95 3331 485413 662497 78593147
Localised infection 73.27 9.95 437 488307 37138 79218506
Product use in unapproved indication 73.25 9.95 1086 487658 249273 79006371
Injection site reaction 72.86 9.95 580 488164 54205 79201439
Ventricular tachycardia 72.60 9.95 90 488654 41845 79213799
Type 2 diabetes mellitus 72.32 9.95 598 488146 56524 79199120
Immune reconstitution inflammatory syndrome 71.81 9.95 3 488741 13838 79241806
Encephalopathy 71.75 9.95 195 488549 67202 79188442
Cerebral haemorrhage 69.91 9.95 156 488588 57517 79198127
Blood pressure increased 69.61 9.95 1742 487002 209618 79046026
Asthenia 69.11 9.95 2503 486241 509186 78746458
Hyperkalaemia 68.58 9.95 415 488329 113983 79141661
Joint laxity 68.33 9.95 78 488666 2266 79253378
Blood pressure diastolic increased 67.93 9.95 220 488524 14322 79241322
Disturbance in attention 67.85 9.95 130 488614 50671 79204973
Disability 67.71 9.95 245 488499 16875 79238769
Mydriasis 67.60 9.95 13 488731 17630 79238014
Cholestasis 67.30 9.95 136 488608 51973 79203671
Nodule 66.86 9.95 299 488445 22695 79232949
Nausea 66.42 9.95 5011 483733 952185 78303459
Myalgia 66.11 9.95 773 487971 184868 79070776
Sepsis 65.88 9.95 1208 487536 268220 78987424
Dyspnoea 65.71 9.95 4448 484296 852577 78403067
Basal cell carcinoma 65.56 9.95 423 488321 36952 79218692
Gestational diabetes 65.33 9.95 129 488615 6164 79249480
Ventricular fibrillation 64.76 9.95 60 488684 31866 79223778
Myocardial infarction 64.68 9.95 769 487975 183360 79072284
Drug ineffective for unapproved indication 64.25 9.95 136 488608 51102 79204542
Body temperature decreased 64.06 9.95 376 488368 31769 79223875
Adverse event 63.66 9.95 606 488138 59608 79196036
Anaphylactic shock 63.64 9.95 76 488668 35920 79219724
Sedation complication 63.42 9.95 10 488734 15659 79239985
Mental status changes 63.14 9.95 205 488539 66754 79188890
Neuroleptic malignant syndrome 63.09 9.95 46 488698 27513 79228131
Tendonitis 62.75 9.95 301 488443 23529 79232115
Red blood cell sedimentation rate 62.57 9.95 118 488626 5447 79250197
Orthostatic hypotension 61.68 9.95 160 488584 56004 79199640
Ejection fraction decreased 61.14 9.95 73 488671 34504 79221140
Ascites 60.90 9.95 247 488497 75315 79180329
Hepatocellular injury 60.80 9.95 125 488619 47468 79208176
Acute hepatic failure 60.61 9.95 57 488687 30056 79225588
Tongue disorder 60.45 9.95 206 488538 13769 79241875
Diabetic ketoacidosis 60.38 9.95 72 488672 34050 79221594
Hypothermia 60.33 9.95 32 488712 22714 79232930
Diarrhoea 60.31 9.95 4614 484130 875875 78379769
Abnormal behaviour 60.13 9.95 81 488663 36340 79219304
Neutrophil count decreased 59.98 9.95 334 488410 93625 79162019
Cardiogenic shock 59.78 9.95 103 488641 41811 79213833
Alanine aminotransferase abnormal 59.72 9.95 153 488591 8714 79246930
Suicidal ideation 58.15 9.95 255 488489 76085 79179559
Blood glucose increased 57.99 9.95 439 488305 114536 79141108
Vision blurred 57.94 9.95 395 488349 105503 79150141
Neurotoxicity 57.13 9.95 69 488675 32449 79223195
Psychotic disorder 57.01 9.95 104 488640 41298 79214346
Restlessness 56.97 9.95 125 488619 46367 79209277
Unresponsive to stimuli 56.73 9.95 165 488579 55623 79200021
Anxiety 56.52 9.95 1128 487616 247384 79008260
Laryngitis 55.55 9.95 220 488524 15819 79239825
Injection site swelling 55.23 9.95 485 488259 46647 79208997
Atrial fibrillation 54.92 9.95 867 487877 197019 79058625
Injection site pain 54.62 9.95 1108 487636 128730 79126914
Bursitis 54.13 9.95 391 488353 35453 79220191
Disorientation 53.93 9.95 200 488544 62576 79193068
Leukopenia 53.64 9.95 456 488288 116057 79139587
Therapeutic response decreased 53.43 9.95 636 488108 66217 79189427
Myoclonus 52.63 9.95 55 488689 27605 79228039
Irritability 52.61 9.95 108 488636 41036 79214608
Infective pulmonary exacerbation of cystic fibrosis 52.47 9.95 8 488736 12843 79242801
Blood creatinine increased 52.39 9.95 653 488091 154404 79101240
Multiple sclerosis relapse 52.31 9.95 131 488613 46402 79209242
Balance disorder 51.99 9.95 373 488371 98484 79157160
Blood parathyroid hormone decreased 51.59 9.95 162 488582 10374 79245270
No adverse event 51.59 9.95 93 488651 37099 79218545
Venoocclusive liver disease 51.23 9.95 6 488738 11765 79243879
Skin ulcer 50.96 9.95 532 488212 53618 79202026
Drug level increased 50.77 9.95 104 488640 39547 79216097
Synovial cyst 50.43 9.95 156 488588 9909 79245735
Speech disorder 50.43 9.95 168 488576 54277 79201367
Femur fracture 50.19 9.95 407 488337 38245 79217399
Hypokalaemia 50.03 9.95 603 488141 143437 79112207
Respiratory distress 50.03 9.95 186 488558 58153 79197491
Oropharyngeal pain 49.64 9.95 944 487800 108409 79147235
Pulmonary arterial hypertension 48.98 9.95 61 488683 28305 79227339
Melaena 48.47 9.95 200 488544 60690 79194954
Pulmonary embolism 48.33 9.95 750 487994 170904 79084740
Inappropriate antidiuretic hormone secretion 48.20 9.95 54 488690 26259 79229385
Fracture 48.06 9.95 262 488482 21539 79234105
Tenderness 48.06 9.95 278 488466 23364 79232280
Latent tuberculosis 47.93 9.95 79 488665 3274 79252370
Granuloma skin 47.66 9.95 144 488600 9030 79246614
Lip dry 47.50 9.95 204 488540 15214 79240430
Facet joint syndrome 47.49 9.95 165 488579 11137 79244507
Cerebral infarction 47.24 9.95 134 488610 45542 79210102
Posterior reversible encephalopathy syndrome 46.99 9.95 55 488689 26226 79229418
Tuberculosis 46.75 9.95 201 488543 14997 79240647
Substance abuse 46.73 9.95 5 488739 10521 79245123
Proteinuria 46.23 9.95 80 488664 32422 79223222
Delirium 46.13 9.95 316 488428 84311 79171333
Brain oedema 46.11 9.95 52 488692 25211 79230433
Aggression 46.00 9.95 159 488585 50799 79204845
Agranulocytosis 45.92 9.95 133 488611 44897 79210747
Extrapyramidal disorder 45.56 9.95 43 488701 22636 79233008
Aspergillus infection 45.15 9.95 31 488713 19130 79236514
Neck deformity 45.10 9.95 56 488688 1781 79253863
Injection site bruising 45.01 9.95 416 488328 40586 79215058
Peripheral venous disease 44.85 9.95 205 488539 15704 79239940
Torsade de pointes 44.51 9.95 32 488712 19280 79236364
Creatinine renal clearance decreased 44.44 9.95 31 488713 18971 79236673
Dizziness 44.37 9.95 2708 486036 523733 78731911
Platelet count decreased 44.12 9.95 884 487860 193780 79061864
Ear infection 43.87 9.95 361 488383 34071 79221573
Miosis 43.69 9.95 21 488723 15768 79239876
Maternal exposure before pregnancy 43.43 9.95 88 488656 4285 79251359
Gamma-glutamyltransferase increased 43.27 9.95 180 488564 54500 79201144
Coagulopathy 43.14 9.95 98 488646 35908 79219736
Second primary malignancy 43.01 9.95 17 488727 14333 79241311
Pathogen resistance 42.98 9.95 17 488727 14325 79241319
Gastrointestinal haemorrhage 42.75 9.95 642 488102 147077 79108567
Ankylosing spondylitis 42.74 9.95 168 488576 12037 79243607
Fear of injection 42.35 9.95 121 488623 7353 79248291
Dysarthria 42.28 9.95 242 488502 67380 79188264
Acute chest syndrome 42.25 9.95 50 488694 1511 79254133
Premature delivery 42.02 9.95 267 488477 23200 79232444
Loss of consciousness 41.96 9.95 750 487994 167193 79088451
Joint dislocation 41.77 9.95 210 488534 16729 79238915
Exostosis 41.57 9.95 209 488535 16649 79238995
Panniculitis 41.49 9.95 168 488576 12203 79243441
Chronic kidney disease 41.23 9.95 237 488507 65917 79189727
Arrhythmia 41.21 9.95 214 488530 61058 79194586
Maternal exposure timing unspecified 41.16 9.95 102 488642 5690 79249954
Withdrawal syndrome 41.10 9.95 63 488681 26791 79228853
Premature labour 41.08 9.95 129 488615 8261 79247383
Deep vein thrombosis postoperative 40.94 9.95 152 488592 10600 79245044
Akathisia 40.92 9.95 15 488729 13244 79242400
Ulcer 40.78 9.95 319 488425 29653 79225991
Bronchopulmonary aspergillosis 40.57 9.95 46 488698 22248 79233396
Wheelchair user 40.47 9.95 105 488639 6027 79249617
Fluid retention 40.40 9.95 256 488488 69553 79186091
Pulmonary oedema 40.35 9.95 346 488398 87908 79167736
Asphyxia 40.19 9.95 11 488733 11709 79243935
Transplant rejection 40.05 9.95 36 488708 19401 79236243
Liver injury 39.85 9.95 526 488218 56088 79199556
Blood bilirubin increased 39.83 9.95 240 488504 65992 79189652
Joint injury 39.64 9.95 328 488416 31007 79224637
Thrombotic microangiopathy 39.63 9.95 39 488705 20130 79235514
Clostridium difficile colitis 39.39 9.95 87 488657 32196 79223448
Emotional distress 39.35 9.95 120 488624 39849 79215795
Rash maculo-papular 39.35 9.95 193 488551 55885 79199759
Poor venous access 39.26 9.95 217 488527 17932 79237712
Wrong technique in product usage process 39.20 9.95 278 488466 73597 79182047
Coronary artery disease 38.98 9.95 238 488506 65236 79190408
Pre-eclampsia 38.94 9.95 113 488631 6928 79248716
Multiple fractures 38.92 9.95 123 488621 7903 79247741
White blood cell count decreased 38.88 9.95 868 487876 187420 79068224
Tumour lysis syndrome 38.75 9.95 54 488690 23885 79231759
Psychomotor hyperactivity 38.73 9.95 28 488716 16821 79238823
Drug use disorder 38.69 9.95 4 488740 8647 79246997
Drug tolerance decreased 38.67 9.95 170 488574 12808 79242836
Lupus-like syndrome 38.65 9.95 178 488566 13679 79241965
Premature rupture of membranes 38.19 9.95 80 488664 3989 79251655
Blood alkaline phosphatase increased 38.12 9.95 231 488513 63433 79192211
Appendicolith 38.12 9.95 4 488740 8547 79247097
Haematotoxicity 38.07 9.95 24 488720 15495 79240149
Limb deformity 37.76 9.95 74 488670 3516 79252128
Adjustment disorder with depressed mood 37.62 9.95 132 488612 8954 79246690
General physical health deterioration 37.46 9.95 2054 486690 273184 78982460
Haemoptysis 37.43 9.95 196 488548 55803 79199841
Anti-cyclic citrullinated peptide antibody 37.39 9.95 99 488645 5753 79249891
Neck mass 37.23 9.95 83 488661 4321 79251323
BK virus infection 37.07 9.95 5 488739 8799 79246845
Dystonia 36.96 9.95 46 488698 21353 79234291
Leukocytosis 36.96 9.95 139 488605 43316 79212328
Sciatica 36.94 9.95 338 488406 32884 79222760
Acute respiratory distress syndrome 36.81 9.95 142 488602 43925 79211719
Haemorrhage intracranial 36.78 9.95 65 488679 26128 79229516
Exposure to toxic agent 36.72 9.95 6 488738 9152 79246492
Retinitis 36.60 9.95 96 488648 5547 79250097
Dyskinesia 36.30 9.95 146 488598 44627 79211017
Cerebrovascular accident 36.15 9.95 702 488042 154590 79101054
Unintentional medical device removal 36.00 9.95 3 488741 7709 79247935
Acute graft versus host disease 35.90 9.95 9 488735 10158 79245486
Obesity 35.89 9.95 351 488393 34774 79220870
Arthritis infective 35.84 9.95 122 488622 8149 79247495
Wound infection 35.82 9.95 261 488483 23730 79231914
Injection site rash 35.77 9.95 210 488534 17744 79237900
Toxic epidermal necrolysis 35.75 9.95 146 488598 44435 79211209
Status epilepticus 35.29 9.95 62 488682 24979 79230665
Smear cervix abnormal 35.25 9.95 59 488685 2477 79253167
Fear 35.19 9.95 50 488694 21936 79233708
Mouth ulceration 35.09 9.95 375 488369 38019 79217625
Chest discomfort 34.95 9.95 615 488129 137429 79118215
Deep vein thrombosis 34.82 9.95 526 488218 120393 79135251
Tachypnoea 34.70 9.95 92 488652 31971 79223673
Acute respiratory failure 34.63 9.95 218 488526 59323 79196321
Malignant mediastinal neoplasm 34.52 9.95 43 488701 1372 79254272
Aphasia 34.45 9.95 158 488586 46574 79209070
Flushing 34.40 9.95 360 488384 87908 79167736
Osteonecrosis of jaw 34.39 9.95 142 488602 43084 79212560
Subdural haematoma 34.17 9.95 90 488654 31344 79224300
Pancreatitis acute 34.07 9.95 172 488572 49432 79206212
Forced expiratory volume decreased 33.96 9.95 4 488740 7810 79247834
Dislocation of vertebra 33.95 9.95 116 488628 7764 79247880
Erythema multiforme 33.69 9.95 35 488709 17616 79238028
Herpes zoster 33.58 9.95 777 487967 92306 79163338
Pleural effusion 33.41 9.95 658 488086 144604 79111040
Immunodeficiency 33.18 9.95 238 488506 21530 79234114
Acute generalised exanthematous pustulosis 33.17 9.95 34 488710 17220 79238424
Tenosynovitis stenosans 33.05 9.95 64 488680 3014 79252630
Spinal stenosis 32.96 9.95 187 488557 15604 79240040
Ischaemic stroke 32.95 9.95 99 488645 33032 79222612
Bradyphrenia 32.90 9.95 12 488732 10628 79245016
Mania 32.87 9.95 38 488706 18222 79237422
Bronchospasm 32.86 9.95 64 488680 24795 79230849
Stevens-Johnson syndrome 32.85 9.95 126 488618 39040 79216604
Foot fracture 32.74 9.95 239 488505 21742 79233902
Product quality issue 32.63 9.95 103 488641 33837 79221807
Face oedema 32.57 9.95 78 488666 28058 79227586
Anaphylactic reaction 32.45 9.95 342 488402 83401 79172243
Eosinophilia 32.43 9.95 155 488589 45190 79210454
Dysgeusia 32.41 9.95 211 488533 56966 79198678
Scleritis 32.33 9.95 78 488666 4278 79251366
Rotator cuff repair 32.21 9.95 48 488696 1822 79253822
Dysphagia 31.92 9.95 541 488203 121595 79134049
Oral herpes 31.90 9.95 282 488462 27172 79228472
Haemophagocytic lymphohistiocytosis 31.75 9.95 53 488691 21784 79233860
Blood calcium decreased 31.70 9.95 95 488649 31724 79223920
Synovial fluid analysis 31.62 9.95 54 488690 2305 79253339
Rheumatoid lung 31.49 9.95 76 488668 4169 79251475
Pulmonary hypertension 31.18 9.95 170 488574 47910 79207734
Feeling abnormal 31.15 9.95 740 488004 158459 79097185
Myelosuppression 31.05 9.95 134 488610 40162 79215482
Hallucination, visual 30.99 9.95 100 488644 32629 79223015
Muscle twitching 30.82 9.95 66 488678 24698 79230946
Angina pectoris 30.82 9.95 188 488556 51544 79204100
Acidosis 30.59 9.95 46 488698 19716 79235928
Decreased appetite 30.47 9.95 1752 486992 340666 78914978
Pyrexia 30.41 9.95 3669 485075 675040 78580604
Gastroenteritis viral 30.38 9.95 258 488486 24573 79231071
Bone disorder 30.32 9.95 211 488533 18902 79236742
Sinus tachycardia 30.14 9.95 120 488624 36788 79218856
Pancytopenia 29.95 9.95 1272 487472 164473 79091171
Hyperthermia 29.89 9.95 40 488704 17997 79237647
Colorectal cancer 29.87 9.95 8 488736 8639 79247005
Accidental overdose 29.67 9.95 133 488611 39448 79216196
Graft versus host disease 29.59 9.95 29 488715 14997 79240647
Haemorrhage 29.55 9.95 387 488357 90731 79164913
Bone pain 29.46 9.95 210 488534 55532 79200112
Depression 29.28 9.95 1060 487684 215730 79039914
Pulmonary alveolar haemorrhage 29.11 9.95 17 488727 11440 79244204
Product administration error 28.99 9.95 99 488645 31747 79223897
Skin cancer 28.73 9.95 174 488570 14866 79240778
Glycosylated haemoglobin increased 28.70 9.95 46 488698 19214 79236430
Device difficult to use 28.54 9.95 24 488720 13361 79242283
International normalised ratio increased 28.53 9.95 357 488387 84364 79171280
Pneumatosis intestinalis 28.50 9.95 3 488741 6394 79249250
Hyperbilirubinaemia 28.36 9.95 68 488676 24450 79231194
Skin papilloma 28.36 9.95 90 488654 5796 79249848
Cytopenia 28.24 9.95 51 488693 20332 79235312
Urinary retention 28.18 9.95 217 488527 56413 79199231
Toxic skin eruption 28.09 9.95 59 488685 22234 79233410
Oxygen saturation decreased 27.93 9.95 1010 487734 128037 79127607
Finger deformity 27.91 9.95 105 488639 7369 79248275
Loose body in joint 27.90 9.95 37 488707 1258 79254386
Cardiomyopathy 27.89 9.95 87 488657 28687 79226957
Malignant melanoma 27.82 9.95 170 488574 14571 79241073
Stress cardiomyopathy 27.76 9.95 17 488727 11149 79244495
Hallucination, auditory 27.59 9.95 53 488691 20640 79235004
Disease recurrence 27.49 9.95 158 488586 43951 79211693
Synovial disorder 27.38 9.95 46 488698 1937 79253707
Adenovirus infection 27.03 9.95 9 488735 8438 79247206
Rhinorrhoea 26.82 9.95 633 488111 75441 79180203
Acute myeloid leukaemia 26.78 9.95 98 488646 30787 79224857
Autoimmune disorder 26.71 9.95 184 488560 16428 79239216
Prescribed overdose 26.67 9.95 352 488392 37531 79218113
Acute graft versus host disease in skin 26.62 9.95 7 488737 7651 79247993
Muscle rigidity 26.44 9.95 51 488693 19831 79235813
Antinuclear antibody positive 26.34 9.95 107 488637 7783 79247861
Shock haemorrhagic 26.21 9.95 52 488692 20008 79235636
Pancreatitis 26.18 9.95 281 488463 68294 79187350
Joint noise 26.18 9.95 68 488676 3906 79251738
Hypomagnesaemia 26.14 9.95 174 488570 46737 79208907
Cyanosis 25.95 9.95 74 488670 25108 79230536
Hemiplegia 25.92 9.95 32 488712 14907 79240737
Metastases to liver 25.79 9.95 88 488656 28226 79227418
Metastases to bone 25.75 9.95 71 488673 24356 79231288
Dyspnoea exertional 25.67 9.95 377 488367 86696 79168948
Cardiac failure acute 25.66 9.95 48 488696 18881 79236763
Bacteraemia 25.39 9.95 109 488635 32715 79222929
Jaundice 25.36 9.95 207 488537 53142 79202502
Dermatitis acneiform 25.15 9.95 15 488729 9978 79245666
Influenza 25.09 9.95 1002 487742 128604 79127040
Haematoma 25.05 9.95 202 488542 51993 79203651
Tardive dyskinesia 25.05 9.95 17 488727 10554 79245090
Cytomegalovirus viraemia 24.95 9.95 25 488719 12796 79242848
Klebsiella infection 24.91 9.95 36 488708 15684 79239960
Aspartate aminotransferase increased 24.80 9.95 653 488091 137988 79117656
Anhedonia 24.73 9.95 33 488711 14865 79240779
Lip swelling 24.72 9.95 148 488596 40763 79214881
Sinus bradycardia 24.71 9.95 76 488668 25171 79230473
Plasma cell myeloma 24.70 9.95 208 488536 53051 79202593
Palpitations 24.63 9.95 589 488155 126021 79129623
Hydrops foetalis 24.58 9.95 27 488717 751 79254893
Blood pressure decreased 24.58 9.95 445 488299 99021 79156623
Hepatitis B reactivation 24.49 9.95 4 488740 6104 79249540
Nocardiosis 24.45 9.95 3 488741 5676 79249968
Injection site warmth 24.40 9.95 165 488579 14642 79241002
Rebound effect 24.38 9.95 7 488737 7219 79248425
Muscle spasms 24.35 9.95 851 487893 173879 79081765
Skin necrosis 24.32 9.95 192 488552 17895 79237749
Acute myocardial infarction 24.32 9.95 329 488415 76707 79178937
Lymphocyte count decreased 24.10 9.95 180 488564 47109 79208535
Fracture delayed union 24.05 9.95 45 488699 2065 79253579
Asthma 23.98 9.95 637 488107 134458 79121186
Human antichimeric antibody positive 23.91 9.95 39 488705 1602 79254042
Drug tolerance 23.88 9.95 111 488633 8564 79247080
Pleuritic pain 23.74 9.95 124 488620 10028 79245616
Respiration abnormal 23.72 9.95 9 488735 7779 79247865
Hemiparesis 23.72 9.95 116 488628 33617 79222027
Sexual dysfunction 23.59 9.95 9 488735 7754 79247890
Anuria 23.57 9.95 59 488685 20904 79234740
Ultrasound antenatal screen 23.56 9.95 25 488719 668 79254976
Ileus 23.51 9.95 82 488662 26129 79229515
Dry skin 23.46 9.95 285 488459 67710 79187934
Cleft lip and palate 23.41 9.95 25 488719 673 79254971
Pemphigoid 23.37 9.95 36 488708 15279 79240365
Urticaria 23.13 9.95 914 487830 184287 79071357
Temperature regulation disorder 23.10 9.95 4 488740 5849 79249795
Cystitis haemorrhagic 22.75 9.95 14 488730 9158 79246486
Lower limb fracture 22.75 9.95 230 488514 22985 79232659
Foot operation 22.63 9.95 82 488662 5651 79249993
Delusion 22.56 9.95 58 488686 20365 79235279
Blood lactic acid increased 22.43 9.95 27 488717 12717 79242927
Pain in jaw 22.43 9.95 178 488566 45973 79209671
Electrocardiogram QRS complex prolonged 22.40 9.95 20 488724 10813 79244831
Bronchitis 22.35 9.95 997 487747 129647 79125997
Hyperammonaemia 22.32 9.95 21 488723 11072 79244572
Postoperative wound infection 22.30 9.95 146 488598 12815 79242829
Musculoskeletal disorder 22.24 9.95 215 488529 21233 79234411
Polyuria 22.24 9.95 36 488708 14978 79240666
Endophthalmitis 22.11 9.95 6 488738 6422 79249222
Hepatic encephalopathy 22.08 9.95 75 488669 24091 79231553
Hypervolaemia 21.99 9.95 162 488582 42528 79213116
Ankle arthroplasty 21.89 9.95 36 488708 1489 79254155
Hyperuricaemia 21.85 9.95 24 488720 11775 79243869
Vertigo 21.82 9.95 295 488449 68787 79186857
Breast cancer stage I 21.68 9.95 7 488737 6693 79248951
Hyperthyroidism 21.63 9.95 67 488677 22142 79233502
Affective disorder 21.63 9.95 12 488732 8307 79247337
Progressive multifocal leukoencephalopathy 21.62 9.95 60 488684 20540 79235104
Paranoia 21.61 9.95 55 488689 19377 79236267
Hypertransaminasaemia 21.27 9.95 25 488719 11899 79243745
Body height below normal 21.21 9.95 42 488702 2011 79253633
Polydipsia 21.20 9.95 7 488737 6598 79249046
Pulmonary haemorrhage 21.14 9.95 36 488708 14681 79240963
Pseudomonas infection 21.12 9.95 62 488682 20841 79234803
Nephropathy toxic 21.04 9.95 60 488684 20359 79235285
Skin exfoliation 20.95 9.95 226 488518 54874 79200770
Pulseless electrical activity 20.93 9.95 34 488710 14126 79241518
Visual acuity reduced 20.91 9.95 101 488643 29368 79226276
Hypophosphataemia 20.90 9.95 58 488686 19855 79235789
Catatonia 20.85 9.95 14 488730 8742 79246902
Onychomycosis 20.78 9.95 103 488641 8158 79247486
Trisomy 18 20.76 9.95 22 488722 587 79255057
Polyneuropathy 20.70 9.95 77 488667 24074 79231570
Cushingoid 20.52 9.95 114 488630 9438 79246206
Peripheral sensory neuropathy 20.50 9.95 30 488714 13003 79242641
Respiratory acidosis 20.50 9.95 23 488721 11177 79244467
Surgery 20.45 9.95 298 488446 32468 79223176
Respiratory disorder 20.43 9.95 176 488568 44680 79210964
Chronic graft versus host disease 20.38 9.95 8 488736 6773 79248871
Anger 20.33 9.95 47 488697 17115 79238529
Troponin increased 20.27 9.95 56 488688 19199 79236445
Septic shock 20.26 9.95 585 488159 122216 79133428
Right ventricular failure 20.09 9.95 75 488669 23422 79232222
Metastases to central nervous system 20.08 9.95 44 488700 16331 79239313
Post procedural infection 20.06 9.95 129 488615 11255 79244389
Coordination abnormal 20.03 9.95 48 488696 17264 79238380
Polyhydramnios 20.00 9.95 37 488707 1683 79253961
Weight decreased 19.88 9.95 2477 486267 352721 78902923
Therapy non-responder 19.86 9.95 722 488022 91583 79164061
Oliguria 19.86 9.95 44 488700 16265 79239379
Potentiating drug interaction 19.82 9.95 15 488729 8804 79246840
Lethargy 19.67 9.95 365 488379 80927 79174717
Hepatic cirrhosis 19.67 9.95 312 488432 34594 79221050
Gastric haemorrhage 19.67 9.95 39 488705 15011 79240633
Hyperlactacidaemia 19.67 9.95 5 488739 5590 79250054
Breast feeding 19.59 9.95 23 488721 689 79254955
Lipase increased 19.58 9.95 45 488699 16421 79239223
Atrioventricular block 19.57 9.95 35 488709 14006 79241638
Short stature 19.46 9.95 23 488721 694 79254950
End stage renal disease 19.35 9.95 28 488716 12192 79243452
Device leakage 19.11 9.95 23 488721 10833 79244811
Chest pain 19.10 9.95 1480 487264 280824 78974820
Foetal distress syndrome 18.99 9.95 19 488725 473 79255171
Hepatotoxicity 18.97 9.95 212 488532 51140 79204504
Labelled drug-drug interaction medication error 18.91 9.95 96 488648 27554 79228090
Hyperprolactinaemia 18.89 9.95 3 488741 4673 79250971
Hepatitis acute 18.87 9.95 42 488702 15500 79240144
Ingrown hair 18.85 9.95 23 488721 718 79254926
Device use error 18.82 9.95 10 488734 7091 79248553
Heart rate irregular 18.76 9.95 293 488451 32386 79223258
Jaundice cholestatic 18.72 9.95 25 488719 11259 79244385
Muscle spasticity 18.72 9.95 68 488676 21407 79234237
Interstitial lung disease 18.68 9.95 536 488208 112064 79143580
Anal fissure 18.64 9.95 95 488649 7608 79248036
Stillbirth 18.62 9.95 60 488684 3895 79251749
Pulmonary congestion 18.59 9.95 94 488650 27006 79228638
Cholangitis 18.58 9.95 31 488713 12745 79242899
Accidental exposure to product 18.57 9.95 114 488630 31208 79224436
Multiple-drug resistance 18.53 9.95 16 488728 8792 79246852
Mental disorder 18.52 9.95 114 488630 31188 79224456
Cardiotoxicity 18.45 9.95 29 488715 12210 79243434
Amylase increased 18.43 9.95 25 488719 11184 79244460
Bradypnoea 18.42 9.95 7 488737 6045 79249599
Hypernatraemia 18.42 9.95 38 488706 14413 79241231
Aphthous ulcer 18.36 9.95 171 488573 16718 79238926
Venoocclusive disease 18.32 9.95 3 488741 4570 79251074
Abdominal distension 18.26 9.95 576 488168 119074 79136570
Radiation inflammation 18.19 9.95 25 488719 880 79254764
Cardiac failure chronic 18.14 9.95 25 488719 11110 79244534
Hepatitis fulminant 18.13 9.95 11 488733 7251 79248393
Endodontic procedure 18.13 9.95 47 488697 2696 79252948
Haematemesis 18.06 9.95 219 488525 52045 79203599
Dactylitis 17.98 9.95 47 488697 2710 79252934
Tubulointerstitial nephritis 17.88 9.95 149 488595 38086 79217558
C-reactive protein 17.81 9.95 69 488675 4910 79250734
Myocardial ischaemia 17.80 9.95 88 488656 25431 79230213
Atrioventricular block complete 17.72 9.95 48 488696 16562 79239082
Acute coronary syndrome 17.71 9.95 68 488676 21065 79234579
Sleep terror 17.70 9.95 3 488741 4455 79251189
Normal newborn 17.67 9.95 88 488656 6984 79248660
Febrile bone marrow aplasia 17.66 9.95 33 488711 12987 79242657
Procedural pain 17.64 9.95 77 488667 23007 79232637
Haematuria 17.63 9.95 306 488438 68530 79187114
Injury 17.62 9.95 610 488134 76886 79178758
Placental disorder 17.60 9.95 25 488719 908 79254736
Purpura 17.57 9.95 61 488683 19466 79236178
Sickle cell anaemia 17.53 9.95 21 488723 643 79255001
Epstein-Barr virus infection 17.46 9.95 39 488705 14377 79241267
Induced labour 17.39 9.95 24 488720 848 79254796
Foetal exposure during pregnancy 17.37 9.95 76 488668 5714 79249930
Product prescribing error 17.36 9.95 183 488561 44630 79211014
Lower respiratory tract congestion 17.36 9.95 59 488685 3938 79251706
Toxic encephalopathy 17.35 9.95 27 488717 11413 79244231
Paralysis 17.35 9.95 34 488710 13143 79242501
Myopathy 17.34 9.95 66 488678 20497 79235147
Renal injury 17.25 9.95 50 488694 16877 79238767
Prostatic specific antigen increased 17.24 9.95 23 488721 10363 79245281
Haemodynamic instability 17.24 9.95 52 488692 17330 79238314
Tuberculin test positive 17.24 9.95 53 488691 3355 79252289
Hyperlipidaemia 17.06 9.95 92 488652 26001 79229643
Pneumonia aspiration 17.05 9.95 298 488446 66669 79188975
Cyst 17.04 9.95 144 488600 13696 79241948
Blood urea increased 17.02 9.95 204 488540 48586 79207058
Oesophageal carcinoma 16.96 9.95 26 488718 11058 79244586
Graft versus host disease in skin 16.92 9.95 8 488736 6065 79249579
Hypoalbuminaemia 16.92 9.95 70 488674 21227 79234417
Myocarditis 16.91 9.95 72 488672 21661 79233983
Bladder cancer 16.90 9.95 62 488682 19464 79236180
Device related infection 16.79 9.95 132 488612 34162 79221482
Rhinitis allergic 16.73 9.95 31 488713 12238 79243406
Erectile dysfunction 16.70 9.95 41 488703 14623 79241021
Lacrimal disorder 16.67 9.95 18 488726 491 79255153
Haematocrit decreased 16.65 9.95 493 488251 60819 79194825
Antibody test positive 16.60 9.95 46 488698 2746 79252898
Hydrocephalus 16.59 9.95 18 488726 8882 79246762
Glomerular filtration rate decreased 16.58 9.95 77 488667 22625 79233019
Presyncope 16.58 9.95 166 488578 40888 79214756
Heparin-induced thrombocytopenia 16.53 9.95 21 488723 9661 79245983
Intracranial pressure increased 16.46 9.95 16 488728 8306 79247338
Eosinophil count increased 16.38 9.95 52 488692 17053 79238591
Hepatitis cholestatic 16.35 9.95 38 488706 13814 79241830
Virologic failure 16.25 9.95 3 488741 4188 79251456
Enterocolitis 16.19 9.95 41 488703 14471 79241173
Lung transplant 16.18 9.95 4 488740 4557 79251087
Incoherent 16.15 9.95 14 488730 7678 79247966
Knee operation 16.10 9.95 75 488669 5791 79249853
Hypothyroidism 16.09 9.95 225 488519 52167 79203477
Hypercholesterolaemia 16.01 9.95 214 488530 22881 79232763
Renal tubular necrosis 15.98 9.95 89 488655 24950 79230694
Nightmare 15.92 9.95 93 488651 25768 79229876
Haemorrhage in pregnancy 15.92 9.95 30 488714 1384 79254260
C-reactive protein decreased 15.91 9.95 44 488700 2624 79253020
Therapy partial responder 15.89 9.95 54 488690 17343 79238301
Clear cell renal cell carcinoma 15.87 9.95 43 488701 2533 79253111
Lymphatic fistula 15.87 9.95 22 488722 781 79254863
Generalised oedema 15.83 9.95 83 488661 23626 79232018
Deformity 15.81 9.95 107 488637 9498 79246146
Blood glucose decreased 15.80 9.95 95 488649 26139 79229505
Nasal polyps 15.79 9.95 13 488731 7314 79248330
Spinal osteoarthritis 15.78 9.95 166 488578 16761 79238883
Rash erythematous 15.71 9.95 254 488490 57515 79198129
Pulmonary tuberculosis 15.67 9.95 92 488652 7773 79247871
Cytomegalovirus chorioretinitis 15.66 9.95 7 488737 5483 79250161
Multiple drug therapy 15.63 9.95 3 488741 4075 79251569
Unevaluable event 15.58 9.95 243 488501 55342 79200302
Multiple allergies 15.57 9.95 25 488719 10435 79245209
Brain natriuretic peptide increased 15.51 9.95 19 488725 8881 79246763
Walking aid user 15.49 9.95 111 488633 10037 79245607
Injection site extravasation 15.49 9.95 107 488637 9562 79246082
Drug screen positive 15.40 9.95 9 488735 6054 79249590
Pharyngitis 15.37 9.95 207 488537 22168 79233476
Wound infection pseudomonas 15.37 9.95 32 488712 1589 79254055
Osteoporotic fracture 15.37 9.95 59 488685 4181 79251463
Transplant dysfunction 15.33 9.95 13 488731 7208 79248436
Joint warmth 15.32 9.95 32 488712 1592 79254052
Coronary arterial stent insertion 15.31 9.95 9 488735 6035 79249609
Chills 15.31 9.95 814 487930 159420 79096224
Ileus paralytic 15.27 9.95 22 488722 9598 79246046
Ventricular arrhythmia 15.27 9.95 19 488725 8821 79246823
Type 1 diabetes mellitus 15.26 9.95 12 488732 6907 79248737
Drug abuser 15.17 9.95 9 488735 6004 79249640
Blood phosphorus increased 15.15 9.95 25 488719 10322 79245322
Blood potassium increased 15.12 9.95 111 488633 29164 79226480
Pharyngitis streptococcal 15.11 9.95 115 488629 10599 79245045
Joint ankylosis 15.08 9.95 38 488706 2142 79253502
Femoral hernia incarcerated 15.06 9.95 22 488722 820 79254824
Hypertriglyceridaemia 15.00 9.95 35 488709 12705 79242939
Tooth infection 14.97 9.95 179 488565 18653 79236991
Spinal disorder 14.96 9.95 111 488633 10149 79245495
Hypophagia 14.96 9.95 192 488552 45175 79210469
Depressed mood 14.96 9.95 208 488536 48272 79207372
Hepatocellular carcinoma 14.95 9.95 20 488724 9001 79246643
Atrial tachycardia 14.95 9.95 13 488731 7120 79248524
Bone density abnormal 14.94 9.95 47 488697 3013 79252631
Genital haemorrhage 14.90 9.95 10 488734 6245 79249399
Metastases to lung 14.87 9.95 59 488685 18104 79237540
Diaphragmatic disorder 14.81 9.95 33 488711 1717 79253927
Generalised tonic-clonic seizure 14.79 9.95 185 488559 43725 79211919
Cytomegalovirus infection reactivation 14.78 9.95 19 488725 8697 79246947
Accidental death 14.77 9.95 4 488740 4287 79251357
Maternal exposure during breast feeding 14.74 9.95 44 488700 2741 79252903
Renal disorder 14.71 9.95 176 488568 41929 79213715
Foetal death 14.70 9.95 92 488652 7952 79247692
Toothache 14.66 9.95 187 488557 19783 79235861
Ligament rupture 14.65 9.95 50 488694 3344 79252300
Hypercapnia 14.62 9.95 20 488724 8915 79246729
Oligoarthritis 14.55 9.95 20 488724 704 79254940
Left ventricular dysfunction 14.54 9.95 65 488679 19296 79236348
Acute pulmonary oedema 14.53 9.95 42 488702 14188 79241456
Subarachnoid haemorrhage 14.52 9.95 89 488655 24376 79231268
Personality change 14.49 9.95 25 488719 10145 79245499
Cervical incompetence 14.46 9.95 17 488727 510 79255134
Product administered to patient of inappropriate age 14.45 9.95 8 488736 5545 79250099
Therapeutic product effect incomplete 14.43 9.95 1031 487713 140614 79115030
Intestinal ischaemia 14.42 9.95 38 488706 13232 79242412
Pulmonary pain 14.41 9.95 60 488684 4413 79251231
Respiratory tract infection viral 14.41 9.95 58 488686 4201 79251443
Immune effector cell-associated neurotoxicity syndrome 14.41 9.95 9 488735 5839 79249805
Hypoxic-ischaemic encephalopathy 14.38 9.95 16 488728 7804 79247840
Drug specific antibody 14.36 9.95 42 488702 2586 79253058
Joint lock 14.36 9.95 48 488696 3177 79252467
Pneumothorax 14.34 9.95 108 488636 28215 79227429
Intervertebral disc degeneration 14.34 9.95 154 488590 15631 79240013
Gestational hypertension 14.33 9.95 34 488710 1845 79253799
Hospitalisation 14.29 9.95 454 488290 93782 79161862
Blood folate increased 14.23 9.95 17 488727 519 79255125
Kidney infection 14.14 9.95 200 488544 21651 79233993
Parkinsonism 14.13 9.95 53 488691 16531 79239113
Placental insufficiency 14.13 9.95 25 488719 1098 79254546
Colitis ulcerative 14.11 9.95 295 488449 34447 79221197
Hypocalcaemia 14.08 9.95 218 488526 49706 79205938
Obstructive airways disorder 14.08 9.95 124 488620 31335 79224309
Hepatic cancer 14.01 9.95 27 488717 10502 79245142
Vascular device infection 13.98 9.95 26 488718 10250 79245394
Osteopenia 13.93 9.95 173 488571 18191 79237453
Human anti-human antibody test 13.92 9.95 15 488729 408 79255236
Panic attack 13.91 9.95 89 488655 24127 79231517
Lymphoedema 13.91 9.95 35 488709 12378 79243266
Metastasis 13.87 9.95 13 488731 6867 79248777
Kidney transplant rejection 13.87 9.95 26 488718 10220 79245424
Abortion threatened 13.87 9.95 15 488729 410 79255234
Uterine perforation 13.81 9.95 11 488733 6292 79249352
Road traffic accident 13.80 9.95 358 488386 43306 79212338
Anti-neutrophil cytoplasmic antibody positive vasculitis 13.76 9.95 3 488741 3726 79251918
Atrial flutter 13.73 9.95 77 488667 21548 79234096
Threatened labour 13.71 9.95 18 488726 606 79255038
Dyslipidaemia 13.66 9.95 32 488712 11601 79244043
Nail injury 13.62 9.95 18 488726 610 79255034
Immunosuppression 13.60 9.95 129 488615 12674 79242970
Defaecation disorder 13.54 9.95 19 488725 682 79254962
Acute lymphocytic leukaemia recurrent 13.51 9.95 6 488738 4718 79250926
Tooth disorder 13.50 9.95 231 488513 26002 79229642
Lymph gland infection 13.32 9.95 17 488727 556 79255088
Plasma cell myeloma recurrent 13.31 9.95 7 488737 4994 79250650
Arthritis bacterial 13.27 9.95 99 488645 9067 79246577
Disturbance in social behaviour 13.17 9.95 7 488737 4963 79250681
Bradykinesia 13.16 9.95 18 488726 8025 79247619
Device dislocation 13.16 9.95 99 488645 25871 79229773
Anticholinergic syndrome 13.14 9.95 3 488741 3608 79252036
Epistaxis 13.14 9.95 554 488190 110961 79144683
Personality disorder 13.13 9.95 11 488733 6135 79249509
Systemic inflammatory response syndrome 13.10 9.95 32 488712 11433 79244211
Lip blister 13.05 9.95 42 488702 2725 79252919
Pericardial effusion 13.01 9.95 202 488542 46035 79209609
Mass 12.99 9.95 164 488580 17308 79238336
Alanine aminotransferase increased 12.99 9.95 840 487904 161730 79093914
Transaminases increased 12.93 9.95 231 488513 51512 79204132
Iodine allergy 12.91 9.95 17 488727 574 79255070
Blood loss anaemia 12.90 9.95 50 488694 15448 79240196
Hyperpyrexia 12.90 9.95 11 488733 6081 79249563
Seronegative arthritis 12.89 9.95 60 488684 4632 79251012
Capillary leak syndrome 12.88 9.95 4 488740 3921 79251723
Complications of transplanted kidney 12.87 9.95 12 488732 6354 79249290
Sensitivity to weather change 12.86 9.95 89 488655 7958 79247686
Oesophageal fibrosis 12.86 9.95 10 488734 176 79255468
Tooth abscess 12.85 9.95 154 488590 16056 79239588
Diplopia 12.83 9.95 137 488607 33329 79222315
Breast abscess 12.81 9.95 28 488716 1438 79254206
Lower gastrointestinal haemorrhage 12.81 9.95 53 488691 16072 79239572
Injection site haemorrhage 12.78 9.95 241 488503 27629 79228015
Mood altered 12.76 9.95 61 488683 17786 79237858
Strongyloidiasis 12.74 9.95 4 488740 3894 79251750
Schizophrenia 12.73 9.95 50 488694 15390 79240254
Alcohol interaction 12.72 9.95 7 488737 4867 79250777
Upper respiratory tract infection 12.71 9.95 682 488062 90486 79165158
Troponin T increased 12.67 9.95 3 488741 3519 79252125
Spondylitis 12.63 9.95 60 488684 4671 79250973
Motor dysfunction 12.61 9.95 47 488697 14686 79240958
Ventricular extrasystoles 12.59 9.95 70 488674 19634 79236010
Myofascial pain syndrome 12.55 9.95 34 488710 2003 79253641
Injection site urticaria 12.53 9.95 127 488617 12699 79242945
Photophobia 12.53 9.95 186 488558 20342 79235302
Mental impairment 12.51 9.95 67 488677 18969 79236675
Bone density increased 12.49 9.95 20 488724 809 79254835
Small for dates baby 12.48 9.95 15 488729 461 79255183
Salivary hypersecretion 12.42 9.95 45 488699 14179 79241465
Benign ovarian tumour 12.41 9.95 13 488731 342 79255302
Cholestasis of pregnancy 12.36 9.95 22 488722 971 79254673
Post procedural haemorrhage 12.32 9.95 43 488701 13701 79241943
Investigation abnormal 12.25 9.95 34 488710 2032 79253612
Onychomadesis 12.24 9.95 64 488680 5178 79250466
Hypomania 12.23 9.95 17 488727 7527 79248117
Alcohol abuse 12.21 9.95 9 488735 5354 79250290
Pneumonia bacterial 12.18 9.95 69 488675 19262 79236382
Red blood cell count decreased 12.16 9.95 449 488295 57064 79198580
Lymphopenia 12.16 9.95 124 488620 30433 79225211
Bronchial secretion retention 12.08 9.95 5 488739 4099 79251545
Skin ulcer haemorrhage 12.06 9.95 16 488728 544 79255100
Device breakage 12.04 9.95 30 488714 10645 79244999
Hypertonia 12.02 9.95 16 488728 7216 79248428
Off label use 12.00 9.95 5201 483543 902014 78353630
Arthropod bite 11.99 9.95 91 488653 8380 79247264
Vein disorder 11.91 9.95 63 488681 5119 79250525
Haemodialysis 11.91 9.95 64 488680 18104 79237540
Rash pruritic 11.89 9.95 545 488199 71084 79184560
Cartilage injury 11.85 9.95 28 488716 1515 79254129
Incorrect route of product administration 11.82 9.95 147 488597 34782 79220862
Faecal calprotectin increased 11.82 9.95 66 488678 5475 79250169
Oxygen consumption increased 11.81 9.95 8 488736 4971 79250673
Tendon disorder 11.79 9.95 80 488664 7106 79248538
Abortion missed 11.78 9.95 25 488719 1258 79254386
Acute graft versus host disease in intestine 11.77 9.95 5 488739 4036 79251608
Insomnia 11.74 9.95 1319 487425 243851 79011793
Extra dose administered 11.71 9.95 21 488723 8394 79247250
Therapy change 11.67 9.95 17 488727 7382 79248262
Catheter site erythema 11.67 9.95 9 488735 5231 79250413
Amyloid arthropathy 11.62 9.95 16 488728 564 79255080
Product preparation error 11.62 9.95 11 488733 5782 79249862
Hepatitis C 11.60 9.95 36 488708 11889 79243755
Coronary artery bypass 11.59 9.95 12 488732 6050 79249594
Inadequate analgesia 11.58 9.95 7 488737 4622 79251022
Hepatitis E antibody positive 11.56 9.95 11 488733 257 79255387
Laryngospasm 11.55 9.95 5 488739 3992 79251652
Catheter management 11.55 9.95 4 488740 3659 79251985
Swollen joint count 11.53 9.95 24 488720 1191 79254453
Euglycaemic diabetic ketoacidosis 11.52 9.95 15 488729 6829 79248815
Ataxia 11.51 9.95 98 488646 24941 79230703
COVID-19 pneumonia 11.51 9.95 117 488627 28732 79226912
Persecutory delusion 11.49 9.95 8 488736 4901 79250743
Ketoacidosis 11.48 9.95 19 488725 7835 79247809
Psychiatric decompensation 11.39 9.95 5 488739 3958 79251686
Hernia 11.39 9.95 157 488587 16902 79238742
Paraesthesia oral 11.37 9.95 76 488668 20395 79235249
Aplasia 11.35 9.95 19 488725 7801 79247843
Peritoneal dialysis complication 11.35 9.95 36 488708 2318 79253326
Skin toxicity 11.34 9.95 21 488723 8293 79247351
Pancreatic steatosis 11.32 9.95 23 488721 1122 79254522
Sleep disorder due to a general medical condition 11.29 9.95 47 488697 14230 79241414
Head injury 11.29 9.95 161 488583 37208 79218436
Concomitant disease aggravated 11.27 9.95 42 488702 13125 79242519
Vascular rupture 11.27 9.95 29 488715 1656 79253988
Drug dose omission by device 11.26 9.95 13 488731 6237 79249407
Stress at work 11.24 9.95 23 488721 1128 79254516
Skin injury 11.22 9.95 46 488698 3360 79252284
Anal fistula 11.22 9.95 77 488667 6867 79248777
Vacuum extractor delivery 11.20 9.95 8 488736 123 79255521
Nervousness 11.17 9.95 141 488603 33274 79222370
Excessive cerumen production 11.17 9.95 18 488726 732 79254912
Congestive cardiomyopathy 11.15 9.95 36 488708 11744 79243900
Renal tubular disorder 11.14 9.95 14 488730 6472 79249172
Renal cancer 11.13 9.95 38 488706 12188 79243456
Limb injury 11.12 9.95 248 488496 29280 79226364
Aspiration 11.11 9.95 75 488669 20083 79235561
Embolism 11.08 9.95 46 488698 13936 79241708
Mycobacterium tuberculosis complex test positive 11.08 9.95 40 488704 2752 79252892
Blood lactate dehydrogenase increased 11.06 9.95 171 488573 38999 79216645
Cholecystitis chronic 11.04 9.95 28 488716 9878 79245766
Haemorrhage subcutaneous 11.04 9.95 8 488736 4801 79250843
Bone cyst 11.02 9.95 46 488698 3387 79252257
Pseudomembranous colitis 11.02 9.95 10 488734 5364 79250280
Hypoventilation 11.00 9.95 17 488727 7207 79248437
Labyrinthitis 10.98 9.95 41 488703 2867 79252777
Angina unstable 10.96 9.95 58 488686 16469 79239175
Metabolic disorder 10.95 9.95 25 488719 9145 79246499
Breast cancer stage III 10.94 9.95 100 488644 9726 79245918
Respiratory syncytial virus infection 10.93 9.95 26 488718 9376 79246268
Skin graft failure 10.93 9.95 10 488734 222 79255422
Bacterial sepsis 10.93 9.95 21 488723 8177 79247467
Joint space narrowing 10.92 9.95 17 488727 671 79254973
Colitis 10.92 9.95 354 488390 72953 79182691
Metabolic encephalopathy 10.87 9.95 25 488719 9122 79246522
Anal skin tags 10.85 9.95 14 488730 463 79255181
Chondropathy 10.84 9.95 37 488707 2475 79253169
Frequent bowel movements 10.78 9.95 247 488497 29292 79226352
Impaired work ability 10.75 9.95 175 488569 19506 79236138
Nail pitting 10.73 9.95 13 488731 403 79255241
Myoglobin blood increased 10.73 9.95 3 488741 3148 79252496
Device occlusion 10.72 9.95 37 488707 11829 79243815
Appendicitis 10.67 9.95 79 488665 20715 79234929
Liver transplant 10.63 9.95 7 488737 4416 79251228
Hepatitis E virus test positive 10.61 9.95 11 488733 286 79255358
Complication of device insertion 10.61 9.95 14 488730 6336 79249308
Lip and/or oral cavity cancer 10.58 9.95 22 488722 1091 79254553
Mitochondrial toxicity 10.54 9.95 3 488741 3111 79252533
Type I hypersensitivity 10.52 9.95 7 488737 4391 79251253
Neck pain 10.47 9.95 564 488180 74853 79180791
Acute lung injury 10.46 9.95 3 488741 3097 79252547
Vascular purpura 10.45 9.95 3 488741 3095 79252549
Eating disorder 10.44 9.95 79 488665 20618 79235026
Psychomotor skills impaired 10.44 9.95 10 488734 5227 79250417
Mesothelioma 10.42 9.95 12 488732 352 79255292
Hypotonia 10.41 9.95 42 488702 12828 79242816
Thirst 10.40 9.95 69 488675 18550 79237094
Temperature intolerance 10.39 9.95 28 488716 9677 79245967
Thiopurine methyltransferase decreased 10.37 9.95 12 488732 354 79255290
Lung disorder 10.32 9.95 598 488146 79959 79175685
Dry eye 10.31 9.95 298 488446 36633 79219011
Blood potassium decreased 10.29 9.95 212 488532 46300 79209344
Abortion incomplete 10.28 9.95 3 488741 3061 79252583
Skin neoplasm excision 10.27 9.95 21 488723 1029 79254615
Diabetes mellitus inadequate control 10.27 9.95 97 488647 24167 79231477
Autonomic nervous system imbalance 10.25 9.95 8 488736 4622 79251022
Palindromic rheumatism 10.24 9.95 13 488731 423 79255221
Memory impairment 10.23 9.95 570 488174 111164 79144480
Pancreatic duct stenosis 10.22 9.95 10 488734 242 79255402
Carotid artery thrombosis 10.22 9.95 3 488741 3050 79252594
Postpartum haemorrhage 10.21 9.95 27 488717 1568 79254076
Complication associated with device 10.20 9.95 64 488680 17432 79238212
Palmoplantar keratoderma 10.19 9.95 5 488739 3711 79251933
Bruxism 10.19 9.95 6 488738 4020 79251624
Decreased insulin requirement 10.18 9.95 8 488736 143 79255501
Umbilical hernia 10.15 9.95 66 488678 5779 79249865
Retinal haemorrhage 10.14 9.95 22 488722 8195 79247449
Adverse drug reaction 10.13 9.95 501 488243 65891 79189753
Vascular insufficiency 10.12 9.95 14 488730 496 79255148
Post-traumatic stress disorder 10.11 9.95 9 488735 4872 79250772
Lupus vulgaris 10.10 9.95 44 488700 3302 79252342
Uveitis 10.08 9.95 152 488592 16678 79238966
Long QT syndrome 10.08 9.95 13 488731 5942 79249702
Cerebral haematoma 10.02 9.95 21 488723 7921 79247723
Folate deficiency 10 9.95 44 488700 3316 79252328
Hyperhomocysteinaemia 9.97 9.95 14 488730 503 79255141
Delivery 9.96 9.95 17 488727 725 79254919
Haemoglobin decreased 9.95 9.95 1529 487215 220590 79035054

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000276 Adjuvants, Immunologic
MeSH PA D016588 Anticarcinogenic Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
MeSH PA D018977 Micronutrients
MeSH PA D014815 Vitamins

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Retinol-binding protein 4 Secreted Kd 6.74 CHEMBL
Amyloid beta A4 protein Unclassified IC50 6.75 CHEMBL
Alpha-synuclein Transporter IC50 6.72 CHEMBL
Beta-lactoglobulin Unclassified Kd 7.44 CHEMBL

External reference:

IDSource
4017713 VUID
N0000179229 NUI
D01621 KEGG_DRUG
4017637 VANDF
4017648 VANDF
4017713 VANDF
4021164 VANDF
C0073109 UMLSCUI
CHEBI:32095 CHEBI
CHEBI:50211 CHEBI
RTL PDB_CHEM_ID
CHEMBL986 ChEMBL_ID
CHEMBL486193 ChEMBL_ID
CHEMBL4297637 ChEMBL_ID
C009166 MESH_SUPPLEMENTAL_RECORD_UI
638034 PUBCHEM_CID
DB00162 DRUGBANK_ID
11246 RXNORM
232172 MMSL
5678 MMSL
975 MMSL
d00402 MMSL
001000 NDDF
001001 NDDF
421621000 SNOMEDCT_US
82156005 SNOMEDCT_US
82622003 SNOMEDCT_US
C0042839 UMLSCUI
2243 INN_ID
445354 PUBCHEM_CID
D014801 MESH_DESCRIPTOR_UI
3LE3D9D6OY UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 1100 [iU] ORAL UNAPPROVED DRUG OTHER 14 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 1100 [iU] ORAL UNAPPROVED DRUG OTHER 13 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 2000 [iU] ORAL UNAPPROVED DRUG OTHER 10 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 3080 [iU] ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 3080 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 15338-522 TABLET, FILM COATED 3080 [iU] ORAL unapproved drug other 8 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-100 LIQUID 1000 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-101 LIQUID 1100 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-103 TABLET, CHEWABLE 1200 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-104 TABLET, CHEWABLE 1200 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-105 TABLET, CHEWABLE 1200 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 17856-0668 TABLET, FILM COATED 3080 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Prenatal Plus Vitamins HUMAN PRESCRIPTION DRUG LABEL 15 39328-106 TABLET 924 ug ORAL UNAPPROVED DRUG OTHER 7 sections
PNV-Select HUMAN PRESCRIPTION DRUG LABEL 18 42192-320 TABLET, FILM COATED 2500 [iU] ORAL unapproved drug other 10 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 42291-686 TABLET, FILM COATED 3080 [iU] ORAL unapproved drug other 8 sections
Poly-ViFlor HUMAN PRESCRIPTION DRUG LABEL 11 42494-432 TABLET, CHEWABLE 600 ug ORAL Unapproved drug other 6 sections
Poly-ViFlor HUMAN PRESCRIPTION DRUG LABEL 11 42494-433 TABLET, CHEWABLE 600 ug ORAL Unapproved drug other 6 sections
Poly-ViFlor HUMAN PRESCRIPTION DRUG LABEL 11 42494-434 TABLET, CHEWABLE 600 ug ORAL Unapproved drug other 6 sections
PNV Prenatal VitaminPlus Vitamin A HUMAN PRESCRIPTION DRUG LABEL 12 44946-1046 TABLET 2500 [iU] ORAL UNAPPROVED DRUG OTHER 9 sections
Prenatal Vitamins Plus Low Iron HUMAN PRESCRIPTION DRUG LABEL 15 50090-0616 TABLET 3080 [iU] ORAL Unapproved drug other 9 sections
PNV Prenatal Plus Multivitamin HUMAN PRESCRIPTION DRUG LABEL 15 50090-0617 TABLET 2000 [iU] ORAL Unapproved drug other 9 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 50268-677 TABLET, FILM COATED 3080 [iU] ORAL unapproved drug other 8 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-173 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-174 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-177 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
Escavite HUMAN PRESCRIPTION DRUG LABEL 17 58809-888 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 10 sections
Vitrexyl HUMAN PRESCRIPTION DRUG LABEL 17 59088-164 TABLET 1500 ug ORAL unapproved drug other 11 sections
Vitrexyl HUMAN PRESCRIPTION DRUG LABEL 17 59088-164 TABLET 1500 ug ORAL unapproved drug other 11 sections
Vitrexyl plus Iron HUMAN PRESCRIPTION DRUG LABEL 18 59088-165 TABLET 1500 ug ORAL unapproved drug other 13 sections
Vitrexyl plus Iron HUMAN PRESCRIPTION DRUG LABEL 18 59088-165 TABLET 1500 ug ORAL unapproved drug other 13 sections