retinol acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
retinol derivatives 2372 127-47-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • retinyl acetate
  • QLT091001
  • retinol acetate
  • Vitamin A acetate
  • Molecular weight: 328.50
  • Formula: C22H32O2
  • CLOGP: 7.35
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 26.30
  • ALOGS: -5.14
  • ROTB: 7

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 5.211 Moderate 0.67
caco2-efflux Caco-2 efflux ratio (BA/AB) 4.325 Moderate 0.67
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.152 10^-6 cm/s Moderate 0.67
dh-clint Dog hepatocyte intrinsic clearance 55.335 uL/min/10^6 cells Moderate 0.67
dppb Dog plasma protein binding (% unbound) 0.190 % Moderate 0.67
fcs-ppb Fetal calf serum protein binding (% unbound) 0.080 % Moderate 0.67
herg hERG pIC50 4.848 pIC50 Moderate 0.67
hh-clint Human hepatocyte intrinsic clearance 86.497 uL/min/10^6 cells Moderate 0.67
hlm-clint Human liver microsomal intrinsic clearance 66.527 uL/min/mg protein Moderate 0.67
hppb Human plasma protein binding (% unbound) 0.180 % Moderate 0.67
kinase-safety-class ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PRKDC,STK33,TEK,TGFBR1 30
kinase-selectivity-class AXL,BRAF,GRK2,MAP2K6,STK33,TEK 6
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.072 Moderate 0.67
mh-clint Mouse hepatocyte intrinsic clearance 291.072 Moderate 0.67
mppb Mouse plasma protein binding (% unbound) 0.140 Moderate 0.67
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.100 Moderate 0.67
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 0.080 % Moderate 0.67
rh-clint Rat hepatocyte intrinsic clearance 175.388 uL/min/10^6 cells Moderate 0.67
rh-fuinc Rat hepatocyte fraction unbound in incubation 0.490 % Moderate 0.67
rppb Rat plasma protein binding (% unbound) 0.200 % Moderate 0.67
solubility-dd Solubility at pH 7.4 in DMSO 0.851 uM Moderate 0.67

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1727.49 9.98 6471 776454 320393 89525129
Systemic lupus erythematosus 1716.26 9.98 6923 776002 354973 89490549
Glossodynia 1473.03 9.98 6090 776835 315689 89529833
Hand deformity 1230.13 9.98 5446 777479 290916 89554606
Arthropathy 1196.16 9.98 6281 776644 359961 89485561
Abdominal discomfort 1077.22 9.98 7433 775492 469895 89375627
Alopecia 1064.47 9.98 7619 775306 487452 89358070
Wound 1001.04 9.98 5214 777711 297766 89547756
Completed suicide 982.09 9.98 70 782855 144988 89700534
Toxicity to various agents 898.83 9.98 702 782223 287144 89558378
Synovitis 893.58 9.98 5380 777545 324372 89521150
Maternal exposure during pregnancy 852.00 9.98 5675 777250 354388 89491134
Anti-cyclic citrullinated peptide antibody positive 831.73 9.98 4142 778783 232291 89613231
Swelling 831.39 9.98 6329 776596 412729 89432793
Pericarditis 826.01 9.98 4552 778373 265599 89579923
Contraindicated product administered 739.82 9.98 5017 777908 315122 89530400
Discomfort 737.82 9.98 4468 778457 269867 89575655
Joint swelling 681.14 9.98 6990 775935 496310 89349212
Duodenal ulcer perforation 674.35 9.98 3726 779199 217562 89627960
Infusion related reaction 638.81 9.98 5942 776983 410838 89434684
Helicobacter infection 621.44 9.98 3713 779212 223137 89622385
Death 589.73 9.98 1998 780927 454553 89390969
Intentional overdose 555.07 9.98 76 782849 93758 89751764
Drug interaction 543.74 9.98 972 781953 275481 89570041
Rheumatoid arthritis 527.12 9.98 5113 777812 357501 89488021
Rheumatoid factor positive 496.75 9.98 2851 780074 168799 89676723
Pain 482.99 9.98 11628 771297 984713 88860809
Psoriatic arthropathy 452.66 9.98 3450 779475 224885 89620637
Febrile neutropenia 450.23 9.98 422 782503 157927 89687595
Hepatic enzyme increased 429.20 9.98 4885 778040 355851 89489671
Drug abuse 403.82 9.98 106 782819 82241 89763281
Therapeutic product effect decreased 391.38 9.98 3890 779035 273681 89571841
Suicide attempt 381.45 9.98 91 782834 75308 89770214
Arthralgia 365.54 9.98 9050 773875 769472 89076050
Musculoskeletal stiffness 363.17 9.98 4039 778886 292493 89553029
Impaired healing 358.11 9.98 3339 779586 230860 89614662
Product use issue 350.21 9.98 4372 778553 325547 89519975
Malignant neoplasm progression 345.61 9.98 251 782674 106619 89738903
Disease progression 344.87 9.98 511 782414 156104 89689418
Constipation 338.31 9.98 1262 781663 279133 89566389
Depressed level of consciousness 332.45 9.98 107 782818 72677 89772845
Folliculitis 324.77 9.98 2938 779987 201415 89644107
Acute kidney injury 313.70 9.98 1561 781364 318826 89526696
Rheumatic fever 313.08 9.98 2331 780594 150790 89694732
Neutropenia 308.84 9.98 957 781968 223947 89621575
Blister 302.02 9.98 3451 779474 251547 89593975
Cardiac arrest 293.14 9.98 284 782641 104651 89740871
Overdose 286.65 9.98 581 782344 157128 89688394
Drug intolerance 279.25 9.98 5422 777503 442169 89403353
Muscle injury 269.63 9.98 2518 780407 174136 89671386
Electrocardiogram QT prolonged 266.11 9.98 147 782778 72309 89773213
Sleep disorder due to general medical condition, insomnia type 258.44 9.98 1951 780974 126743 89718779
Irritable bowel syndrome 255.32 9.98 2829 780096 204619 89640903
Swollen joint count increased 251.06 9.98 1734 781191 109472 89736050
Type 2 diabetes mellitus 245.72 9.98 2762 780163 200482 89645040
Lactic acidosis 241.68 9.98 68 782857 50395 89795127
Nausea 240.73 9.98 7536 775389 1102780 88742742
Fibromyalgia 240.33 9.98 2783 780142 203486 89642036
Hyperhidrosis 239.39 9.98 512 782413 135793 89709729
Hypersensitivity 238.56 9.98 5370 777555 449307 89396215
Exposure during pregnancy 236.13 9.98 3120 779805 235290 89610232
Treatment failure 233.55 9.98 3806 779119 300122 89545400
Somnolence 228.07 9.98 979 781946 208105 89637417
Nasopharyngitis 227.47 9.98 4852 778073 402252 89443270
Hypotension 225.31 9.98 1765 781160 323632 89521890
Hip arthroplasty 221.71 9.98 1268 781657 74940 89770582
Lower respiratory tract infection 220.56 9.98 3212 779713 247447 89598075
Hyponatraemia 219.52 9.98 520 782405 133018 89712504
Knee arthroplasty 217.59 9.98 1346 781579 81836 89763686
Sedation 216.16 9.98 73 782852 48098 89797424
Blood cholesterol increased 212.57 9.98 2738 780187 205274 89640248
C-reactive protein abnormal 210.00 9.98 1847 781078 125582 89719940
Ill-defined disorder 201.88 9.98 2464 780461 182427 89663095
Cardiac failure 196.71 9.98 406 782519 109090 89736432
Drug ineffective for unapproved indication 190.06 9.98 177 782748 66467 89779055
Bradycardia 190.01 9.98 268 782657 83579 89761943
Stomatitis 181.11 9.98 3357 779568 271341 89574181
Liver injury 178.84 9.98 2256 780669 168311 89677211
Drug reaction with eosinophilia and systemic symptoms 173.27 9.98 76 782849 42682 89802840
Red blood cell sedimentation rate abnormal 173.04 9.98 531 782394 23673 89821849
Tremor 172.08 9.98 709 782216 152464 89693058
Agitation 169.06 9.98 198 782727 66900 89778622
Anaemia 168.79 9.98 2093 780832 350709 89494813
Neoplasm progression 168.12 9.98 87 782838 44399 89801123
Renal failure 165.56 9.98 578 782347 130429 89715093
Serotonin syndrome 165.55 9.98 60 782865 37827 89807695
Cognitive disorder 163.16 9.98 216 782709 69191 89776331
Myelosuppression 161.66 9.98 135 782790 53456 89792066
Diarrhoea 160.59 9.98 6561 776364 932629 88912893
Contusion 159.01 9.98 3051 779874 248165 89597357
Rhabdomyolysis 157.24 9.98 127 782798 51129 89794393
Renal impairment 156.67 9.98 432 782493 104989 89740533
Osteoarthritis 156.18 9.98 2467 780458 193263 89652259
Thrombocytopenia 150.10 9.98 1120 781805 207605 89637917
Coma 149.34 9.98 248 782677 72384 89773138
Intentional product use issue 145.49 9.98 2658 780267 214234 89631288
Chest discomfort 143.51 9.98 660 782265 137705 89707817
Angioedema 143.41 9.98 211 782714 64665 89780857
Sickle cell anaemia with crisis 142.58 9.98 239 782686 7058 89838464
Syncope 141.67 9.98 626 782299 132037 89713485
Hypoglycaemia 141.30 9.98 241 782684 69607 89775915
Sopor 140.98 9.98 22 782903 24622 89820900
Injury 140.34 9.98 2441 780484 194908 89650614
Neuropathy peripheral 139.90 9.98 657 782268 136313 89709209
Off label use 138.46 9.98 7954 774971 1094298 88751224
Respiratory failure 138.13 9.98 540 782385 117878 89727644
No adverse event 136.21 9.98 236 782689 67746 89777776
Macular degeneration 135.17 9.98 80 782845 37890 89807632
Drug resistance 135.13 9.98 47 782878 30402 89815120
Respiratory arrest 133.73 9.98 60 782865 33251 89812271
Myalgia 133.02 9.98 925 782000 174200 89671322
Pregnancy 130.96 9.98 952 781973 61095 89784427
Joint range of motion decreased 126.32 9.98 1756 781169 133887 89711635
Metabolic acidosis 126.10 9.98 178 782747 55498 89790024
Intentional self-injury 125.58 9.98 48 782877 29286 89816236
General physical health deterioration 124.42 9.98 3980 778945 351135 89494387
Facet joint syndrome 123.33 9.98 1347 781578 97042 89748480
Cytokine release syndrome 122.73 9.98 44 782881 27929 89817593
Neutrophil count decreased 122.01 9.98 273 782652 71259 89774263
Sinusitis 121.44 9.98 3850 779075 339238 89506284
Multiple organ dysfunction syndrome 119.69 9.98 257 782668 68079 89777443
Intentional product misuse 119.58 9.98 386 782539 89218 89756304
Hepatic function abnormal 119.42 9.98 134 782791 46154 89799368
Grip strength decreased 119.09 9.98 1274 781651 91302 89754220
Weight increased 118.59 9.98 4572 778353 413355 89432167
Inflammation 118.12 9.98 2184 780741 176408 89669114
Live birth 116.81 9.98 1120 781805 77987 89767535
Peripheral swelling 116.44 9.98 4516 778409 408590 89436932
Cardio-respiratory arrest 116.04 9.98 231 782694 62909 89782613
Fatigue 114.29 9.98 11506 771419 1142517 88703005
COVID-19 113.88 9.98 922 782003 167921 89677601
Hepatic failure 112.70 9.98 106 782819 39622 89805900
Seizure 112.58 9.98 813 782112 151816 89693706
Vision blurred 112.06 9.98 530 782395 109763 89735759
Hyperglycaemia 111.46 9.98 167 782758 50803 89794719
Tachycardia 111.46 9.98 850 782075 156823 89688699
White blood cell count decreased 111.12 9.98 916 782009 166193 89679329
Sedation complication 109.55 9.98 10 782915 16934 89828588
Orthostatic hypotension 109.10 9.98 120 782805 41707 89803815
Palpitations 108.91 9.98 712 782213 136016 89709506
Rash 107.38 9.98 8122 774803 787978 89057544
Mobility decreased 106.85 9.98 2880 780045 247854 89597668
Balance disorder 106.75 9.98 453 782472 96627 89748895
Dry skin 106.34 9.98 396 782529 87677 89757845
Multiple sclerosis relapse 106.23 9.98 180 782745 52125 89793397
Dysphagia 105.78 9.98 554 782371 111724 89733798
Dyspnoea 105.04 9.98 6387 776538 874568 88970954
Device expulsion 104.78 9.98 119 782806 40767 89804755
Altered state of consciousness 104.62 9.98 72 782853 31460 89814062
Blood glucose increased 104.38 9.98 445 782480 94801 89750721
Hypoxia 104.37 9.98 301 782624 72098 89773424
Accidental exposure to product 103.56 9.98 128 782797 42238 89803284
Pulmonary fibrosis 101.41 9.98 1395 781530 106108 89739414
Dehydration 101.20 9.98 1132 781793 193315 89652207
Deep vein thrombosis postoperative 99.89 9.98 993 781932 69816 89775706
Metastases to bone 99.20 9.98 48 782877 25457 89820065
Condition aggravated 99.03 9.98 6183 776742 589362 89256160
Anaphylactic reaction 95.25 9.98 410 782515 87114 89758408
Lip dry 94.81 9.98 1309 781616 99646 89745876
Platelet count decreased 94.64 9.98 743 782182 136226 89709296
Blood pressure systolic abnormal 94.61 9.98 376 782549 19102 89826420
Blood pressure diastolic abnormal 94.35 9.98 381 782544 19500 89826022
Palmar-plantar erythrodysaesthesia syndrome 94.30 9.98 63 782862 27960 89817562
Product dose omission issue 93.57 9.98 1866 781059 289821 89555701
Drug withdrawal syndrome 93.43 9.98 67 782858 28656 89816866
Infection 93.35 9.98 3921 779004 358173 89487349
Encephalopathy 93.25 9.98 161 782764 46283 89799239
Erythema 92.99 9.98 1406 781519 227840 89617682
Shock 92.48 9.98 68 782857 28710 89816812
Suicidal ideation 91.18 9.98 329 782596 73526 89771996
Hepatocellular injury 91.03 9.98 70 782855 28888 89816634
Feeling abnormal 90.85 9.98 964 781961 166271 89679251
Anaphylactic shock 90.11 9.98 84 782841 31533 89813989
Colitis 90.09 9.98 306 782619 69636 89775886
Dysarthria 89.62 9.98 212 782713 54270 89791252
Food allergy 88.85 9.98 55 782870 25423 89820099
Hyperkalaemia 88.68 9.98 277 782648 64687 89780835
Temperature regulation disorder 88.14 9.98 11 782914 14568 89830954
Vomiting 88.03 9.98 5749 777176 782544 89062978
Creatinine renal clearance decreased 87.69 9.98 27 782898 18872 89826650
Hallucination 87.41 9.98 285 782640 65674 89779848
Wrong technique in product usage process 86.93 9.98 321 782604 71250 89774272
Sepsis 86.92 9.98 1064 781861 178750 89666772
Skin exfoliation 86.20 9.98 299 782626 67614 89777908
Restlessness 86.18 9.98 109 782816 35611 89809911
Rash erythematous 83.74 9.98 285 782640 64819 89780703
Ejection fraction decreased 83.12 9.98 63 782862 26190 89819332
Anxiety 82.68 9.98 2040 780885 307732 89537790
Obesity 82.65 9.98 1326 781599 104181 89741341
Cardiac failure congestive 81.63 9.98 508 782417 98186 89747336
Disability assessment scale score increased 81.17 9.98 132 782793 3799 89841723
Drug dependence 81.15 9.98 80 782845 29247 89816275
Asthenia 81.08 9.98 3776 779149 529975 89315547
Cytomegalovirus infection 80.25 9.98 67 782858 26535 89818987
Mydriasis 80.21 9.98 16 782909 14996 89830526
Ventricular tachycardia 79.89 9.98 58 782867 24650 89820872
Autoimmune disorder 79.50 9.98 1013 781912 75731 89769791
Leukopenia 79.40 9.98 526 782399 100184 89745338
Blood calcium decreased 79.37 9.98 86 782839 30096 89815426
Disturbance in attention 79.35 9.98 181 782744 46928 89798594
Diabetic ketoacidosis 79.30 9.98 57 782868 24350 89821172
Abortion spontaneous 77.67 9.98 761 782164 53295 89792227
Joint effusion 77.60 9.98 357 782568 19353 89826169
Wound infection 77.36 9.98 1321 781604 105081 89740441
Foot deformity 77.22 9.98 822 782103 58829 89786693
C-reactive protein increased 76.24 9.98 2080 780845 179309 89666213
Back pain 76.13 9.98 2121 780804 315054 89530468
Arthritis 75.91 9.98 1938 780987 165377 89680145
Cholestasis 75.49 9.98 123 782802 36176 89809346
Red blood cell sedimentation rate increased 74.35 9.98 1063 781862 81532 89763990
Neurotoxicity 73.95 9.98 47 782878 21420 89824102
Metastases to liver 73.65 9.98 84 782841 28723 89816799
Schizophrenia 73.48 9.98 19 782906 14895 89830627
Drug level increased 73.12 9.98 79 782846 27683 89817839
Cough 72.82 9.98 2532 780393 366430 89479092
Flushing 72.40 9.98 457 782468 88034 89757488
Sciatica 72.37 9.98 1255 781670 100127 89745395
Blood creatinine increased 72.37 9.98 545 782380 100841 89744681
Blood pressure systolic increased 71.83 9.98 796 782129 57549 89787973
Myocardial infarction 71.74 9.98 578 782347 105394 89740128
Personality disorder 71.43 9.98 11 782914 12433 89833089
Ascites 71.39 9.98 195 782730 47545 89797977
Gamma-glutamyltransferase increased 71.34 9.98 137 782788 37815 89807707
Product use in unapproved indication 71.15 9.98 2287 780638 333949 89511573
Respiratory depression 70.93 9.98 23 782902 15552 89829970
Blood pressure decreased 70.84 9.98 369 782556 74526 89770996
Hypercholesterolaemia 70.61 9.98 1245 781680 99647 89745875
Acute hepatic failure 69.07 9.98 56 782869 22505 89823017
Hypokalaemia 67.93 9.98 764 782161 130352 89715170
Blood creatine phosphokinase increased 67.34 9.98 119 782806 33904 89811618
Osteonecrosis of jaw 66.87 9.98 149 782776 38954 89806568
Disorientation 66.86 9.98 179 782746 43935 89801587
Blood pressure fluctuation 66.79 9.98 720 782205 51693 89793829
Breast cancer stage III 66.77 9.98 1063 781862 83384 89762138
Dermatitis atopic 66.14 9.98 63 782862 23409 89822113
Extrapyramidal disorder 66.02 9.98 29 782896 16274 89829248
Device difficult to use 65.15 9.98 35 782890 17490 89828032
Joint destruction 64.95 9.98 257 782668 13030 89832492
Torsade de pointes 64.73 9.98 25 782900 15157 89830365
Chronic sinusitis 64.63 9.98 66 782859 23736 89821786
Bursitis 64.51 9.98 1541 781384 130113 89715409
Adjustment disorder with depressed mood 64.35 9.98 762 782163 55991 89789531
Fluid retention 64.08 9.98 471 782454 87620 89757902
Aphasia 63.92 9.98 175 782750 42637 89802885
Metastases to central nervous system 63.81 9.98 36 782889 17506 89828016
Musculoskeletal pain 63.75 9.98 1934 780991 169317 89676205
Dislocation of vertebra 63.69 9.98 752 782173 55216 89790306
Cerebral haemorrhage 63.69 9.98 126 782799 34396 89811126
Pulmonary embolism 63.62 9.98 773 782152 130047 89715475
Peripheral venous disease 63.23 9.98 1048 781877 82873 89762649
Blood bilirubin increased 63.19 9.98 180 782745 43290 89802232
Disease recurrence 63.15 9.98 145 782780 37508 89808014
Blood alkaline phosphatase increased 62.84 9.98 209 782716 47870 89797652
Unresponsive to stimuli 62.17 9.98 149 782776 37972 89807550
Parkinsonism 61.92 9.98 22 782903 14043 89831479
Poisoning 61.73 9.98 27 782898 15190 89830332
Gastrointestinal disorder 61.72 9.98 2760 780165 253927 89591595
Gait inability 61.69 9.98 1680 781245 144776 89700746
Emotional distress 61.63 9.98 141 782784 36521 89809001
Adverse event 61.11 9.98 1386 781539 116032 89729490
Bone erosion 61.05 9.98 714 782211 52307 89793215
Juvenile idiopathic arthritis 60.73 9.98 117 782808 3860 89841662
Loss of consciousness 60.72 9.98 849 782076 139389 89706133
Hemiparesis 60.56 9.98 114 782811 31705 89813817
Foetal exposure during pregnancy 60.28 9.98 602 782323 42373 89803149
Posterior reversible encephalopathy syndrome 59.47 9.98 63 782862 22276 89823246
Disseminated intravascular coagulation 59.31 9.98 59 782866 21479 89824043
Depressed mood 59.20 9.98 228 782697 49994 89795528
Thrombotic microangiopathy 59.17 9.98 31 782894 15712 89829810
Therapy partial responder 58.87 9.98 62 782863 21981 89823541
Polyarthritis 58.47 9.98 313 782612 18037 89827485
Withdrawal syndrome 58.32 9.98 65 782860 22459 89823063
Cerebrovascular accident 58.17 9.98 735 782190 122798 89722724
Exposure via skin contact 58.06 9.98 11 782914 10694 89834828
Procedural pain 57.96 9.98 126 782799 33234 89812288
Hemiplegia 57.59 9.98 34 782891 16126 89829396
Vertigo 57.38 9.98 360 782565 69451 89776071
Akathisia 57.36 9.98 13 782912 11146 89834376
Bone pain 57.16 9.98 308 782617 61675 89783847
Chronic kidney disease 57.16 9.98 231 782694 49960 89795562
Hypothermia 56.60 9.98 32 782893 15543 89829979
Road traffic accident 56.50 9.98 1272 781653 106354 89739168
Mental status changes 56.50 9.98 197 782728 44482 89801040
Exposure to toxic agent 56.43 9.98 3 782922 7964 89837558
Atrial fibrillation 56.04 9.98 814 782111 132797 89712725
Aspartate aminotransferase increased 56.03 9.98 593 782332 102344 89743178
Eating disorder 55.73 9.98 98 782827 27975 89817547
Angina pectoris 55.57 9.98 164 782761 38996 89806526
Hypomania 55.56 9.98 6 782919 8891 89836631
Dizziness 55.50 9.98 4360 778565 584924 89260598
Nasal polyps 55.28 9.98 13 782912 10867 89834655
Psychotic disorder 55.06 9.98 117 782808 31113 89814409
Skin haemorrhage 55.03 9.98 62 782863 21318 89824204
Carotid artery thrombosis 54.62 9.98 7 782918 9085 89836437
Dysgeusia 54.30 9.98 251 782674 52309 89793213
Basal cell carcinoma 53.95 9.98 482 782443 32907 89812615
Paraesthesia oral 53.03 9.98 122 782803 31537 89813985
Hypomagnesaemia 52.73 9.98 146 782779 35442 89810080
Pulmonary oedema 52.65 9.98 317 782608 61763 89783759
Joint laxity 52.58 9.98 87 782838 2541 89842981
Respiratory distress 52.49 9.98 167 782758 38779 89806743
Joint stiffness 52.47 9.98 957 781968 77085 89768437
Ventricular fibrillation 52.27 9.98 28 782897 14016 89831506
Polyneuropathy 52.10 9.98 54 782871 19287 89826235
Pain in jaw 52.07 9.98 225 782700 47760 89797762
Pancreatitis acute 52.00 9.98 126 782799 31989 89813533
Inappropriate antidiuretic hormone secretion 51.93 9.98 55 782870 19450 89826072
Dyskinesia 51.85 9.98 153 782772 36381 89809141
Swollen tongue 51.40 9.98 213 782712 45743 89799779
Headache 51.27 9.98 6600 776325 856146 88989376
Proteinuria 51.22 9.98 76 782849 23215 89822307
Alanine aminotransferase increased 51.02 9.98 717 782208 117621 89727901
Gestational diabetes 50.37 9.98 203 782722 10379 89835143
Vaginal flatulence 50.36 9.98 23 782902 12615 89832907
Hepatotoxicity 50.33 9.98 214 782711 45628 89799894
Speech disorder 49.92 9.98 213 782712 45372 89800150
Brain oedema 49.76 9.98 46 782879 17339 89828183
Second primary malignancy 49.66 9.98 14 782911 10364 89835158
Eczema 49.15 9.98 262 782663 52608 89792914
Bronchospasm 49.12 9.98 64 782861 20645 89824877
Myoclonus 48.88 9.98 56 782869 19112 89826410
Miosis 48.85 9.98 11 782914 9473 89836049
Arrhythmia 48.73 9.98 194 782731 42138 89803384
Acute respiratory failure 48.58 9.98 198 782727 42720 89802802
Face oedema 48.50 9.98 79 782846 23239 89822283
Toxic skin eruption 48.48 9.98 39 782886 15735 89829787
Status epilepticus 48.29 9.98 55 782870 18819 89826703
Haematotoxicity 48.13 9.98 24 782901 12511 89833011
Sleep disorder 47.96 9.98 2131 780794 195899 89649623
Stevens-Johnson syndrome 47.76 9.98 115 782810 29261 89816261
Abnormal behaviour 47.69 9.98 76 782849 22552 89822970
Prescribed underdose 47.69 9.98 912 782013 74107 89771415
Muscle spasticity 47.23 9.98 152 782773 35170 89810352
Acute generalised exanthematous pustulosis 47.20 9.98 30 782895 13673 89831849
Diabetes mellitus inadequate control 47.20 9.98 55 782870 18629 89826893
Loss of personal independence in daily activities 46.93 9.98 1523 781402 134582 89710940
Eye pruritus 46.91 9.98 114 782811 28913 89816609
Lower limb fracture 46.60 9.98 1011 781914 84002 89761520
Proctitis 46.56 9.98 38 782887 15221 89830301
Dystonia 46.40 9.98 46 782879 16773 89828749
Drug tolerance decreased 45.99 9.98 452 782473 31678 89813844
C-reactive protein 45.75 9.98 443 782482 30924 89814598
Haemorrhage 45.74 9.98 381 782544 68988 89776534
Lethargy 45.72 9.98 338 782587 62801 89782721
Coordination abnormal 45.70 9.98 71 782854 21285 89824237
Psoriasis 45.31 9.98 1631 781294 146123 89699399
Caesarean section 45.09 9.98 295 782630 18282 89827240
Pleural effusion 44.99 9.98 688 782237 111303 89734219
Muscle twitching 44.93 9.98 88 782837 24114 89821408
Osteoporosis 44.91 9.98 1122 781803 95409 89750113
Illness 44.70 9.98 472 782453 81497 89764025
Cytopenia 44.48 9.98 51 782874 17398 89828124
Gastrointestinal haemorrhage 44.35 9.98 532 782393 89716 89755806
Adjustment disorder 44.33 9.98 14 782911 9628 89835894
Rebound effect 44.28 9.98 13 782912 9371 89836151
Aggression 43.68 9.98 104 782821 26564 89818958
Irritability 43.26 9.98 160 782765 35502 89810020
Arterial occlusive disease 43.21 9.98 27 782898 12419 89833103
Multiple drug therapy 43.08 9.98 5 782920 7004 89838518
Haemophagocytic lymphohistiocytosis 42.97 9.98 42 782883 15417 89830105
Rhinitis allergic 42.85 9.98 49 782876 16736 89828786
Metastases to lung 42.68 9.98 45 782880 15946 89829576
Affect lability 42.66 9.98 56 782869 18007 89827515
Transplant rejection 42.50 9.98 29 782896 12729 89832793
Anti-cyclic citrullinated peptide antibody 42.47 9.98 390 782535 26831 89818691
Dry mouth 42.46 9.98 1971 780954 182088 89663434
Injection site reaction 41.87 9.98 1067 781858 91013 89754509
Female genital tract fistula 41.59 9.98 56 782869 17812 89827710
X-ray abnormal 41.43 9.98 586 782339 44838 89800684
Lymphocyte count decreased 41.39 9.98 159 782766 34891 89810631
Myocarditis 41.36 9.98 35 782890 13771 89831751
Premature labour 41.16 9.98 226 782699 13150 89832372
Hyperlipidaemia 41.11 9.98 85 782840 22831 89822691
Bronchopulmonary aspergillosis 40.59 9.98 24 782901 11374 89834148
Coagulopathy 40.43 9.98 88 782837 23201 89822321
Cardiogenic shock 40.41 9.98 95 782830 24373 89821149
Blood pressure diastolic decreased 40.18 9.98 381 782544 26445 89819077
Motor dysfunction 40.14 9.98 65 782860 19165 89826357
Eosinophilia 40.12 9.98 120 782805 28413 89817109
Hypothyroidism 40.12 9.98 281 782644 52846 89792676
Fall 40.02 9.98 3600 779325 478210 89367312
Obstructive airways disorder 39.94 9.98 104 782821 25765 89819757
Small for dates baby 39.73 9.98 114 782811 4893 89840629
Mania 39.69 9.98 38 782887 14086 89831436
Muscle rigidity 39.63 9.98 39 782886 14270 89831252
Cerebral infarction 39.49 9.98 109 782816 26487 89819035
Chills 39.41 9.98 854 782071 131127 89714395
Sinus tachycardia 39.32 9.98 121 782804 28392 89817130
Tachypnoea 39.12 9.98 78 782847 21231 89824291
Oedema 39.00 9.98 2110 780815 198185 89647337
Tardive dyskinesia 38.94 9.98 23 782902 10907 89834615
Atrioventricular block complete 38.87 9.98 18 782907 9793 89835729
Forced expiratory volume decreased 38.73 9.98 3 782922 5805 89839717
Drug dose omission by device 38.67 9.98 20 782905 10211 89835311
Laryngitis 38.67 9.98 635 782290 50118 89795404
Lupus-like syndrome 38.28 9.98 614 782311 48232 89797290
Disability 38.11 9.98 528 782397 40217 89805305
Nodule 37.99 9.98 375 782550 26311 89819211
Abdominal pain 37.95 9.98 2923 780002 392798 89452724
Neck deformity 37.94 9.98 68 782857 2121 89843401
Hospitalisation 37.93 9.98 830 782095 127270 89718252
Sensory loss 37.82 9.98 61 782864 18014 89827508
Nightmare 37.79 9.98 82 782843 21643 89823879
Pain in extremity 37.74 9.98 4445 778480 446084 89399438
Tumour lysis syndrome 37.62 9.98 25 782900 11127 89834395
Acute myeloid leukaemia 37.50 9.98 76 782849 20564 89824958
Stress cardiomyopathy 37.45 9.98 36 782889 13319 89832203
Radiculopathy 37.28 9.98 64 782861 18441 89827081
Graft versus host disease 37.13 9.98 12 782913 8132 89837390
Asphyxia 37.07 9.98 8 782917 7095 89838427
Joint dislocation 37.07 9.98 566 782359 44016 89801506
Dyspnoea exertional 36.73 9.98 423 782502 71865 89773657
Hypoaesthesia 36.70 9.98 3172 779753 311038 89534484
Mental disorder 36.64 9.98 149 782776 32169 89813353
Clostridium difficile colitis 36.35 9.98 114 782811 26592 89818930
Pulmonary arterial hypertension 36.20 9.98 111 782814 26076 89819446
Deep vein thrombosis 36.07 9.98 565 782360 91055 89754467
Haematoma 36.02 9.98 194 782731 38854 89806668
Vaginal discharge 35.94 9.98 71 782854 19393 89826129
Haemorrhage intracranial 35.82 9.98 47 782878 15115 89830407
Paradoxical drug reaction 35.73 9.98 4 782921 5762 89839760
Melaena 35.45 9.98 167 782758 34630 89810892
Neuroleptic malignant syndrome 35.45 9.98 47 782878 15049 89830473
Tuberculosis 35.31 9.98 207 782718 12342 89833180
Onychomycosis 35.23 9.98 485 782440 36891 89808631
Diabetes mellitus 35.19 9.98 374 782551 64501 89781021
Tinnitus 35.04 9.98 223 782702 42879 89802643
Lupus vulgaris 34.79 9.98 565 782360 44494 89801028
Hallucination, visual 34.76 9.98 94 782831 22998 89822524
Paralysis 34.51 9.98 29 782896 11449 89834073
Jaundice 34.35 9.98 154 782771 32363 89813159
Aspergillus infection 34.23 9.98 26 782899 10797 89834725
Device use error 34.08 9.98 10 782915 7211 89838311
Urinary retention 34.01 9.98 189 782736 37555 89807967
Haemoptysis 33.90 9.98 160 782765 33160 89812362
Rheumatoid nodule 33.55 9.98 293 782632 19873 89825649
Hepatic cytolysis 33.52 9.98 145 782780 30771 89814751
Gangrene 33.51 9.98 37 782888 12839 89832683
Lung disorder 33.49 9.98 1600 781325 148283 89697239
International normalised ratio increased 33.45 9.98 255 782670 47061 89798461
Mucosal inflammation 33.41 9.98 327 782598 57298 89788224
Acute graft versus host disease 33.36 9.98 4 782921 5464 89840058
Wheelchair user 32.89 9.98 144 782781 7641 89837881
Substance abuse 32.87 9.98 4 782921 5402 89840120
Panic attack 32.83 9.98 117 782808 26248 89819274
Epistaxis 32.82 9.98 527 782398 84598 89760924
Hepatic cirrhosis 32.70 9.98 746 782179 62507 89783015
Heart rate decreased 32.50 9.98 646 782279 52859 89792663
Haematochezia 32.24 9.98 425 782500 70488 89775034
Pseudomonas infection 32.21 9.98 49 782876 14816 89830706
Infective pulmonary exacerbation of cystic fibrosis 32.11 9.98 25 782900 10254 89835268
Product preparation error 32.00 9.98 25 782900 10236 89835286
Multiple fractures 31.77 9.98 165 782760 9397 89836125
Device related infection 31.73 9.98 115 782810 25671 89819851
Skin burning sensation 31.70 9.98 77 782848 19534 89825988
Bradyphrenia 31.69 9.98 13 782912 7599 89837923
Cardiotoxicity 31.59 9.98 31 782894 11358 89834164
Retinitis 31.49 9.98 487 782438 37971 89807551
Exostosis 31.43 9.98 639 782286 52495 89793027
Circulatory collapse 31.36 9.98 110 782815 24794 89820728
Maternal drugs affecting foetus 31.33 9.98 107 782818 5048 89840474
Lip swelling 31.27 9.98 200 782725 38410 89807112
Epstein-Barr virus infection 31.26 9.98 26 782899 10318 89835204
Onychomadesis 31.24 9.98 565 782360 45433 89800089
Swelling face 31.24 9.98 504 782421 80848 89764674
Multiple-drug resistance 31.22 9.98 14 782911 7762 89837760
Inappropriate schedule of product administration 31.14 9.98 1022 781903 148911 89696611
Erythema multiforme 30.99 9.98 36 782889 12210 89833312
Maternal exposure before pregnancy 30.93 9.98 184 782741 11029 89834493
Complication of device removal 30.76 9.98 8 782917 6247 89839275
Infusion site pain 30.74 9.98 79 782846 19659 89825863
Ischaemic stroke 30.61 9.98 94 782831 22072 89823450
Tenderness 30.56 9.98 361 782564 26507 89819015
Dysuria 30.44 9.98 207 782718 39194 89806328
Sleep apnoea syndrome 30.25 9.98 156 782769 31591 89813931
Acute graft versus host disease in skin 30.24 9.98 3 782922 4753 89840769
Acute respiratory distress syndrome 30.22 9.98 136 782789 28550 89816972
Ventricular septal defect 30.08 9.98 109 782816 5298 89840224
Psychomotor hyperactivity 29.98 9.98 40 782885 12773 89832749
Nervousness 29.89 9.98 172 782753 33884 89811638
Cardiomyopathy 29.86 9.98 83 782842 20123 89825399
Accidental overdose 29.81 9.98 134 782791 28139 89817383
Pericardial effusion 29.72 9.98 191 782734 36642 89808880
Leukocytosis 29.69 9.98 152 782773 30838 89814684
Oral candidiasis 29.56 9.98 182 782743 35273 89810249
Lymphopenia 29.53 9.98 100 782825 22781 89822741
Jaundice cholestatic 29.43 9.98 26 782899 10017 89835505
Complication of device insertion 29.42 9.98 28 782897 10408 89835114
Glycosylated haemoglobin increased 29.40 9.98 56 782869 15506 89830016
Product prescribing error 29.36 9.98 147 782778 29998 89815524
Crying 29.22 9.98 118 782807 25527 89819995
Immune reconstitution inflammatory syndrome 29.20 9.98 12 782913 7007 89838515
Febrile bone marrow aplasia 28.79 9.98 25 782900 9713 89835809
Rash maculo-papular 28.75 9.98 221 782704 40712 89804810
Genital haemorrhage 28.70 9.98 20 782905 8682 89836840
Product administration error 28.60 9.98 124 782801 26299 89819223
Premature rupture of membranes 28.38 9.98 109 782816 5449 89840073
Hot flush 28.35 9.98 353 782572 59135 89786387
Aspiration 28.33 9.98 58 782867 15635 89829887
Vascular device infection 28.28 9.98 37 782888 11915 89833607
Drug hypersensitivity 28.25 9.98 3540 779385 460069 89385453
Influenza like illness 28.17 9.98 508 782417 80103 89765419
Product prescribing issue 28.13 9.98 17 782908 7962 89837560
Fear 27.88 9.98 64 782861 16558 89828964
Interstitial lung disease 27.82 9.98 478 782447 75927 89769595
Ketoacidosis 27.81 9.98 7 782918 5588 89839934
Pathogen resistance 27.63 9.98 18 782907 8097 89837425
Device dislocation 27.63 9.98 159 782766 31323 89814199
Pyrexia 27.48 9.98 5157 777768 655328 89190194
Pulmonary hypertension 27.38 9.98 235 782690 42288 89803234
Dysphonia 27.26 9.98 382 782543 62702 89782820
Toxic epidermal necrolysis 27.11 9.98 167 782758 32361 89813161
Sinus disorder 27.10 9.98 180 782745 34267 89811255
Product administered to patient of inappropriate age 26.97 9.98 4 782921 4649 89840873
Pemphigoid 26.90 9.98 23 782902 9003 89836519
Delusion 26.86 9.98 49 782876 13791 89831731
Wheezing 26.79 9.98 2397 780528 235683 89609839
Urinary incontinence 26.77 9.98 202 782723 37364 89808158
Hypophosphataemia 26.73 9.98 55 782870 14799 89830723
Hypophagia 26.68 9.98 191 782734 35746 89809776
Blood pressure diastolic increased 26.64 9.98 197 782728 12709 89832813
Blood urea increased 26.48 9.98 154 782771 30259 89815263
Respiratory acidosis 26.33 9.98 19 782906 8100 89837422
Myopathy 26.11 9.98 48 782877 13470 89832052
Transaminases increased 26.03 9.98 201 782724 36991 89808531
Eye irritation 26.01 9.98 179 782746 33799 89811723
Dysmorphism 25.99 9.98 64 782861 2504 89843018
Blood potassium decreased 25.95 9.98 275 782650 47452 89798070
Incorrect dose administered 25.85 9.98 503 782422 78427 89767095
Body temperature decreased 25.78 9.98 317 782608 23499 89822023
Enthesopathy 25.73 9.98 154 782771 9250 89836272
Acute chest syndrome 25.70 9.98 40 782885 1108 89844414
Cytomegalovirus infection reactivation 25.62 9.98 18 782907 7782 89837740
Hyperbilirubinaemia 25.59 9.98 51 782874 13885 89831637
Sinus bradycardia 25.52 9.98 69 782856 16883 89828639
Purpura 25.52 9.98 56 782869 14722 89830800
Subarachnoid haemorrhage 25.39 9.98 75 782850 17829 89827693
Blood glucose decreased 25.33 9.98 110 782815 23319 89822203
Limb deformity 25.08 9.98 86 782839 4066 89841456
Toxic encephalopathy 24.92 9.98 23 782902 8676 89836846
Graft versus host disease in gastrointestinal tract 24.91 9.98 4 782921 4384 89841138
Anuria 24.90 9.98 57 782868 14761 89830761
Hypervolaemia 24.86 9.98 173 782752 32584 89812938
Breast cancer metastatic 24.79 9.98 59 782866 15073 89830449
Heart rate increased 24.79 9.98 764 782161 112138 89733384
Eosinophil count increased 24.78 9.98 47 782878 13034 89832488
Right ventricular failure 24.74 9.98 84 782841 19121 89826401
Ankylosing spondylitis 24.62 9.98 196 782729 12937 89832585
Middle insomnia 24.61 9.98 69 782856 16682 89828840
Bradykinesia 24.59 9.98 14 782911 6774 89838748
Labelled drug-drug interaction medication error 24.58 9.98 56 782869 14526 89830996
Renal tubular necrosis 24.45 9.98 56 782869 14499 89831023
Device breakage 24.43 9.98 53 782872 13991 89831531
Ileus 24.42 9.98 68 782857 16478 89829044
Smear cervix abnormal 24.42 9.98 71 782854 3071 89842451
Seronegative arthritis 24.41 9.98 253 782672 17981 89827541
Pulmonary congestion 24.36 9.98 86 782839 19347 89826175
Maternal exposure timing unspecified 24.23 9.98 299 782626 22184 89823338
Multiple sclerosis 24.22 9.98 141 782784 27699 89817823
Atrial septal defect 23.93 9.98 137 782788 8097 89837425
Acidosis 23.91 9.98 46 782879 12690 89832832
Paranoia 23.91 9.98 47 782878 12861 89832661
Sexual dysfunction 23.90 9.98 6 782919 4798 89840724
Blepharospasm 23.90 9.98 638 782287 54807 89790715
Treatment noncompliance 23.88 9.98 309 782616 51418 89794104
Latent tuberculosis 23.85 9.98 68 782857 2908 89842614
Lymphoedema 23.85 9.98 52 782873 13701 89831821
Polyuria 23.84 9.98 31 782894 10009 89835513
Ear infection 23.84 9.98 780 782145 68995 89776527
Drug effective for unapproved indication 23.81 9.98 20 782905 7898 89837624
Atrial tachycardia 23.72 9.98 11 782914 5979 89839543
Mood altered 23.46 9.98 73 782852 17071 89828451
Malignant mediastinal neoplasm 23.46 9.98 43 782882 1365 89844157
Rales 23.40 9.98 65 782860 15762 89829760
Multiple allergies 23.30 9.98 61 782864 15085 89830437
Pallor 23.27 9.98 186 782739 33979 89811543
Glomerular filtration rate decreased 23.24 9.98 72 782853 16860 89828662
Presyncope 23.15 9.98 170 782755 31635 89813887
Colitis microscopic 23.03 9.98 38 782887 11121 89834401
Pulseless electrical activity 22.88 9.98 26 782899 8906 89836616
Breast cancer female 22.86 9.98 60 782865 14826 89830696
Bradypnoea 22.82 9.98 6 782919 4652 89840870
Systemic inflammatory response syndrome 22.81 9.98 14 782911 6502 89839020
Electrocardiogram QRS complex prolonged 22.79 9.98 18 782907 7330 89838192
Schizoaffective disorder 22.74 9.98 8 782917 5139 89840383
Bacteraemia 22.73 9.98 107 782818 22193 89823329
Dissociation 22.72 9.98 15 782910 6700 89838822
Subdural haematoma 22.69 9.98 71 782854 16574 89828948
Antinuclear antibody positive 22.58 9.98 147 782778 9094 89836428
Cyanosis 22.49 9.98 89 782836 19366 89826156
Complication associated with device 22.47 9.98 89 782836 19360 89826162
Prescribed overdose 22.41 9.98 1045 781880 96580 89748942
Acute myocardial infarction 22.38 9.98 193 782732 34697 89810825
Acute pulmonary oedema 22.32 9.98 30 782895 9550 89835972
Drug tolerance 22.31 9.98 245 782680 17671 89827851
Agranulocytosis 22.28 9.98 194 782731 34808 89810714
Pulmonary alveolar haemorrhage 22.26 9.98 12 782913 5986 89839536
Chronic obstructive pulmonary disease 22.24 9.98 477 782448 73352 89772170
Tubulointerstitial nephritis 22.24 9.98 128 782797 25215 89820307
Throat tightness 22.23 9.98 156 782769 29328 89816194
Rheumatoid lung 22.22 9.98 82 782843 4021 89841501
Atrioventricular block 22.21 9.98 26 782899 8789 89836733
Metastases to lymph nodes 22.14 9.98 42 782883 11647 89833875
Generalised oedema 22.13 9.98 87 782838 18966 89826556
Oliguria 22.09 9.98 36 782889 10588 89834934
Head injury 22.08 9.98 168 782757 31020 89814502
Blood lactic acid increased 22.00 9.98 26 782899 8752 89836770
Finger deformity 21.96 9.98 403 782522 32494 89813028
Skin toxicity 21.80 9.98 16 782909 6763 89838759
Cytomegalovirus viraemia 21.80 9.98 20 782905 7566 89837956
Respiration abnormal 21.71 9.98 22 782903 7941 89837581
Rotator cuff repair 21.58 9.98 58 782867 2396 89843126
Hyperuricaemia 21.43 9.98 16 782909 6703 89838819
Gastroenteritis viral 21.38 9.98 375 782550 29980 89815542
Localised infection 21.32 9.98 408 782517 33154 89812368
Hypernatraemia 21.26 9.98 30 782895 9357 89836165
Sneezing 21.10 9.98 161 782764 29708 89815814
Insurance issue 21.08 9.98 39 782886 10919 89834603
Product adhesion issue 21.05 9.98 9 782916 5133 89840389
Product administration interrupted 21.03 9.98 48 782877 12444 89833078
Synovial disorder 20.99 9.98 67 782858 3051 89842471
Chronic graft versus host disease 20.92 9.98 5 782920 4134 89841388
Body height below normal 20.86 9.98 53 782872 2115 89843407
Adenovirus infection 20.74 9.98 7 782918 4615 89840907
Hepatitis acute 20.72 9.98 39 782886 10848 89834674
Respiratory tract congestion 20.68 9.98 145 782780 27265 89818257
Tenosynovitis stenosans 20.58 9.98 78 782847 3875 89841647
Placental disorder 20.57 9.98 44 782881 1567 89843955
Blood test abnormal 20.51 9.98 102 782823 20850 89824672
Device issue 20.49 9.98 160 782765 29377 89816145
Transplant dysfunction 20.45 9.98 10 782915 5272 89840250
Therapy interrupted 20.40 9.98 307 782618 49801 89795721
Synovial fluid analysis 20.31 9.98 62 782863 2756 89842766
Total lung capacity increased 20.22 9.98 9 782916 5012 89840510
Urinary tract infection 20.20 9.98 2321 780604 303311 89542211
Hallucinations, mixed 20.14 9.98 13 782912 5876 89839646
Product storage error 20.12 9.98 98 782827 20143 89825379
Sputum discoloured 20.11 9.98 99 782826 20292 89825230
Troponin increased 20.04 9.98 54 782871 13227 89832295
Hyperprolactinaemia 19.98 9.98 11 782914 5422 89840100
Developmental hip dysplasia 19.90 9.98 43 782882 1542 89843980
Bone marrow failure 19.89 9.98 180 782745 32041 89813481
Therapeutic response shortened 19.84 9.98 116 782809 22763 89822759
Nail operation 19.82 9.98 48 782877 1858 89843664
Hallucination, auditory 19.82 9.98 71 782854 15904 89829618
Systemic candida 19.80 9.98 9 782916 4950 89840572
Clostridium test positive 19.77 9.98 11 782914 5390 89840132
Device leakage 19.72 9.98 35 782890 9956 89835566
Salivary hypersecretion 19.67 9.98 30 782895 9062 89836460
Dementia 19.63 9.98 123 782802 23738 89821784
Sleep terror 19.62 9.98 7 782918 4457 89841065
Infusion site erythema 19.58 9.98 57 782868 13613 89831909
Red blood cell sedimentation rate 19.56 9.98 86 782839 4572 89840950
Abdominal distension 19.54 9.98 925 782000 129676 89715846
Night sweats 19.52 9.98 1327 781598 127439 89718083
Acute coronary syndrome 19.49 9.98 40 782885 10773 89834749
Impaired gastric emptying 19.39 9.98 52 782873 12757 89832765
Walking aid user 19.37 9.98 422 782503 35084 89810438
Immune effector cell-associated neurotoxicity syndrome 19.36 9.98 13 782912 5755 89839767
Stillbirth 19.18 9.98 120 782805 7323 89838199
Laryngospasm 19.01 9.98 3 782922 3330 89842192
Injection site pruritus 18.96 9.98 604 782321 53230 89792292
Neck mass 18.90 9.98 75 782850 3807 89841715
Body temperature increased 18.87 9.98 272 782653 44438 89801084
Blindness 18.86 9.98 143 782782 26425 89819097
Loose body in joint 18.72 9.98 39 782886 1363 89844159
Electrolyte imbalance 18.72 9.98 124 782801 23621 89821901
Therapy non-responder 18.68 9.98 1397 781528 135307 89710215
Foetal anticonvulsant syndrome 18.64 9.98 26 782899 651 89844871
Klebsiella infection 18.64 9.98 38 782887 10259 89835263
Visual acuity reduced 18.58 9.98 122 782803 23288 89822234
Affective disorder 18.57 9.98 24 782901 7769 89837753
Progressive multifocal leukoencephalopathy 18.49 9.98 71 782854 15584 89829938
Post-traumatic stress disorder 18.46 9.98 19 782906 6809 89838713
Bone lesion 18.46 9.98 17 782908 6420 89839102
Cardiac disorder 18.45 9.98 363 782562 56509 89789013
Plasma cell myeloma 18.44 9.98 245 782680 40583 89804939
Immune-mediated enterocolitis 18.43 9.98 9 782916 4748 89840774
Blood pressure inadequately controlled 18.38 9.98 16 782909 6208 89839314
Renal injury 18.37 9.98 38 782887 10205 89835317
Diplopia 18.35 9.98 159 782766 28555 89816967
Shock haemorrhagic 18.32 9.98 50 782875 12195 89833327
Hereditary angioedema 18.31 9.98 33 782892 9332 89836190
Tumour marker increased 18.30 9.98 14 782911 5793 89839729
Nail disorder 18.09 9.98 652 782273 58415 89787107
Diabetes insipidus 18.08 9.98 3 782922 3209 89842313
Bundle branch block left 18.06 9.98 25 782900 7860 89837662
Spinal stenosis 18.04 9.98 230 782695 17194 89828328
Rhinovirus infection 18.01 9.98 15 782910 5948 89839574
Anti-neutrophil cytoplasmic antibody positive vasculitis 18.00 9.98 6 782919 3987 89841535
Renal disorder 17.91 9.98 225 782700 37634 89807888
Hepatitis B reactivation 17.87 9.98 6 782919 3968 89841554
End stage renal disease 17.86 9.98 29 782896 8542 89836980
Asthma 17.86 9.98 1825 781100 240335 89605187
Cleft lip and palate 17.85 9.98 27 782898 729 89844793
Postoperative wound infection 17.83 9.98 186 782739 13240 89832282
Generalised tonic-clonic seizure 17.82 9.98 204 782721 34699 89810823
Pulmonary haemorrhage 17.76 9.98 26 782899 7987 89837535
Blood lactate dehydrogenase increased 17.75 9.98 141 782784 25791 89819731
Cholelithiasis 17.69 9.98 333 782592 52173 89793349
Lacrimation increased 17.67 9.98 149 782776 26913 89818609
Haematemesis 17.66 9.98 196 782729 33530 89811992
Injection site erythema 17.66 9.98 1030 781895 97472 89748050
Pre-eclampsia 17.60 9.98 159 782766 10889 89834633
Nystagmus 17.49 9.98 22 782903 7205 89838317
Ankle arthroplasty 17.42 9.98 59 782866 2772 89842750
Bundle branch block right 17.37 9.98 13 782912 5440 89840082
Coronary artery disease 17.37 9.98 196 782729 33427 89812095
Blood phosphorus decreased 17.37 9.98 11 782914 5023 89840499
Temperature intolerance 17.35 9.98 50 782875 11980 89833542
Hyperlactacidaemia 17.32 9.98 7 782918 4129 89841393
Anosmia 17.27 9.98 37 782888 9811 89835711
Hyperthermia 17.17 9.98 40 782885 10295 89835227
Synovial cyst 17.15 9.98 166 782759 11586 89833936
Amyloid arthropathy 17.14 9.98 42 782883 1638 89843884
Tenosynovitis 17.14 9.98 197 782728 14370 89831152
Enterocolitis 17.11 9.98 41 782884 10449 89835073
Pruritus genital 17.09 9.98 9 782916 4549 89840973
Euglycaemic diabetic ketoacidosis 17.06 9.98 17 782908 6184 89839338
Hypoalbuminaemia 16.97 9.98 75 782850 15822 89829700
Pharyngeal swelling 16.91 9.98 38 782887 9906 89835616
Pseudomonal sepsis 16.88 9.98 8 782917 4294 89841228
Malaise 16.86 9.98 4656 778269 581330 89264192
Anhedonia 16.86 9.98 47 782878 11384 89834138
Haemodynamic instability 16.77 9.98 49 782876 11690 89833832
Feeding disorder 16.71 9.98 86 782839 17426 89828096
Product dose omission in error 16.71 9.98 106 782819 20397 89825125
Dermatitis exfoliative 16.63 9.98 14 782911 5522 89840000
Human antichimeric antibody positive 16.50 9.98 43 782882 1743 89843779
Thrombosis 16.49 9.98 494 782431 72757 89772765
Antibody test positive 16.41 9.98 60 782865 2929 89842593
Hypogammaglobulinaemia 16.41 9.98 43 782882 10631 89834891
Hypoglycaemic coma 16.37 9.98 3 782922 2987 89842535
Ventricular extrasystoles 16.37 9.98 59 782866 13191 89832331
Hyperthyroidism 16.32 9.98 92 782833 18218 89827304
Hepatic necrosis 16.21 9.98 19 782906 6419 89839103
Extra dose administered 16.21 9.98 34 782891 9084 89836438
Potentiating drug interaction 16.18 9.98 15 782910 5647 89839875
Cardiac failure acute 16.18 9.98 51 782874 11878 89833644
Congenital arterial malformation 16.16 9.98 17 782908 314 89845208
Malignant melanoma 16.13 9.98 173 782752 12403 89833119
Peripheral sensory neuropathy 16.02 9.98 35 782890 9215 89836307
Septic shock 16.00 9.98 580 782345 83580 89761942
Personality change 15.99 9.98 24 782901 7297 89838225
Infusion site swelling 15.97 9.98 50 782875 11670 89833852
Femur fracture 15.96 9.98 516 782409 45566 89799956
Infusion site pruritus 15.95 9.98 21 782904 6744 89838778
Type 1 diabetes mellitus 15.95 9.98 11 782914 4801 89840721
Arthritis infective 15.93 9.98 121 782804 7871 89837651
Spondylitis 15.91 9.98 190 782735 13988 89831534
Pain of skin 15.91 9.98 78 782847 16004 89829518
Skin lesion 15.88 9.98 227 782698 37138 89808384
Liver disorder 15.86 9.98 1235 781690 120034 89725488
Pneumatosis intestinalis 15.79 9.98 5 782920 3432 89842090
Staphylococcal infection 15.77 9.98 309 782616 48130 89797392
Dermatitis acneiform 15.74 9.98 19 782906 6335 89839187
Trigeminal neuralgia 15.73 9.98 8 782917 4123 89841399
Neutrophilia 15.71 9.98 16 782909 5762 89839760
Catheter site pain 15.69 9.98 15 782910 5564 89839958
Limb reduction defect 15.65 9.98 23 782902 605 89844917
Amylase increased 15.63 9.98 23 782902 7049 89838473
Pneumonia viral 15.60 9.98 33 782892 8790 89836732
Clear cell renal cell carcinoma 15.60 9.98 39 782886 1541 89843981
Laryngeal oedema 15.58 9.98 22 782903 6859 89838663
Facial paralysis 15.56 9.98 75 782850 15459 89830063
Pneumonitis 15.54 9.98 278 782647 43892 89801630
Skin plaque 15.48 9.98 40 782885 9935 89835587
Lymphatic fistula 15.42 9.98 37 782888 1424 89844098
Scleritis 15.36 9.98 87 782838 5121 89840401
Maternal exposure during delivery 15.32 9.98 7 782918 3839 89841683
Skin papilloma 15.28 9.98 92 782833 5538 89839984
Polyhydramnios 15.19 9.98 52 782873 2456 89843066
Candida infection 15.15 9.98 205 782720 33852 89811670
Hypertelorism 15.14 9.98 21 782904 523 89844999
Ileus paralytic 15.10 9.98 13 782912 5072 89840450
Rash macular 15.06 9.98 178 782747 30102 89815420
Nasal oedema 15.04 9.98 103 782822 6481 89839041
Unevaluable event 14.93 9.98 360 782565 54488 89791034
Activated partial thromboplastin time prolonged 14.92 9.98 28 782897 7797 89837725
Device malfunction 14.85 9.98 113 782812 20864 89824658
Nasal obstruction 14.82 9.98 53 782872 2559 89842963
Breast feeding 14.76 9.98 27 782898 856 89844666
Device physical property issue 14.75 9.98 3 782922 2773 89842749
Product substitution issue 14.72 9.98 93 782832 17915 89827607
Nephropathy toxic 14.70 9.98 58 782867 12630 89832892
Erythema of eyelid 14.68 9.98 5 782920 3278 89842244
Sleep disorder due to a general medical condition 14.68 9.98 285 782640 44453 89801069
Femoral hernia incarcerated 14.65 9.98 37 782888 1471 89844051
Neuralgia 14.60 9.98 188 782737 31312 89814210
Retrognathia 14.55 9.98 21 782904 543 89844979
Rectal haemorrhage 14.46 9.98 576 782349 82168 89763354
Bezoar 14.43 9.98 3 782922 2731 89842791
Hyperammonaemia 14.36 9.98 21 782904 6454 89839068
Loss of employment 14.35 9.98 4 782921 2983 89842539
Hyperpyrexia 14.35 9.98 12 782913 4749 89840773
Lung opacity 14.33 9.98 19 782906 6083 89839439
Reversible cerebral vasoconstriction syndrome 14.28 9.98 9 782916 4121 89841401
Haematuria 14.24 9.98 214 782711 34723 89810799
Intracranial pressure increased 14.24 9.98 23 782902 6788 89838734
Bone density increased 14.20 9.98 27 782898 882 89844640
Pneumothorax 14.17 9.98 102 782823 19065 89826457
Immune thrombocytopenia 14.14 9.98 63 782862 13263 89832259
Back injury 14.12 9.98 514 782411 46108 89799414
Wound infection pseudomonas 14.10 9.98 44 782881 1979 89843543
Varicella zoster virus infection 14.04 9.98 8 782917 3869 89841653
Hypoventilation 14.02 9.98 15 782910 5281 89840241
Skin ulcer 13.96 9.98 547 782378 49528 89795994
Epstein-Barr virus associated lymphoproliferative disorder 13.92 9.98 3 782922 2664 89842858
Confusional state 13.92 9.98 3645 779280 382560 89462962
Haemorrhage in pregnancy 13.85 9.98 46 782879 2139 89843383
Ulcer haemorrhage 13.78 9.98 311 782614 26010 89819512
Kidney transplant rejection 13.73 9.98 13 782912 4844 89840678
Mouth ulceration 13.69 9.98 447 782478 39527 89805995
Long QT syndrome 13.69 9.98 9 782916 4028 89841494
Abortion incomplete 13.67 9.98 5 782920 3135 89842387
Restless legs syndrome 13.67 9.98 126 782799 22344 89823178
Crohn's disease 13.63 9.98 80 782845 4771 89840751
Brain injury 13.63 9.98 29 782896 7709 89837813
Polydipsia 13.59 9.98 10 782915 4221 89841301
Impaired quality of life 13.55 9.98 131 782794 23013 89822509
Exercise tolerance decreased 13.55 9.98 28 782897 7523 89837999
Hepatitis cholestatic 13.54 9.98 34 782891 8527 89836995
Metastasis 13.52 9.98 20 782905 6117 89839405
Fracture delayed union 13.50 9.98 50 782875 2456 89843066
Speech disorder developmental 13.50 9.98 27 782898 916 89844606
Increased appetite 13.49 9.98 54 782871 11711 89833811
Blood sodium decreased 13.48 9.98 163 782762 27450 89818072
Feeling hot 13.42 9.98 544 782381 77464 89768058
Short stature 13.40 9.98 29 782896 1041 89844481
Hypokinesia 13.39 9.98 80 782845 15617 89829905
Ataxia 13.34 9.98 96 782829 17946 89827576
Cholecystitis chronic 13.33 9.98 42 782883 9784 89835738
Pancreatitis 13.32 9.98 481 782444 69345 89776177
Amenorrhoea 13.31 9.98 54 782871 11668 89833854
Choking 13.31 9.98 56 782869 11977 89833545
Incoherent 13.29 9.98 14 782911 4963 89840559
Pneumonia bacterial 13.26 9.98 61 782864 12729 89832793
Iritis 13.23 9.98 65 782860 3621 89841901
Atrial flutter 13.22 9.98 48 782877 10710 89834812
Nocardiosis 13.20 9.98 3 782922 2567 89842955
Hepatitis fulminant 13.10 9.98 9 782916 3936 89841586
Central nervous system lesion 13.01 9.98 54 782871 11592 89833930
Skin weeping 12.99 9.98 4 782921 2796 89842726
Full blood count abnormal 12.99 9.98 230 782695 36367 89809155
Device use issue 12.97 9.98 8 782917 3705 89841817
Gastroschisis 12.95 9.98 17 782908 401 89845121
Hepatic encephalopathy 12.94 9.98 68 782857 13704 89831818
Eosinophilic granulomatosis with polyangiitis 12.90 9.98 3 782922 2527 89842995
Neoplasm recurrence 12.88 9.98 6 782919 3253 89842269
Nail injury 12.83 9.98 24 782901 774 89844748
Carotid artery occlusion 12.72 9.98 22 782903 6320 89839202
Endophthalmitis 12.71 9.98 13 782912 4672 89840850
Product residue present 12.71 9.98 11 782914 4280 89841242
Pregnancy with contraceptive device 12.70 9.98 15 782910 5051 89840471
Dyspepsia 12.66 9.98 1924 781001 196236 89649286
Hypercapnia 12.64 9.98 24 782901 6653 89838869
Congenital anomaly 12.60 9.98 96 782829 6251 89839271
Eyelid oedema 12.56 9.98 54 782871 11480 89834042
Myocardial ischaemia 12.54 9.98 69 782856 13745 89831777
Atrioventricular block second degree 12.48 9.98 12 782913 4440 89841082
Needle issue 12.43 9.98 70 782855 13864 89831658
Cushingoid 12.42 9.98 141 782784 10254 89835268
Thirst 12.39 9.98 86 782839 16209 89829313
Eye swelling 12.32 9.98 179 782746 29207 89816315
Anger 12.20 9.98 69 782856 13651 89831871
Lipase increased 12.11 9.98 52 782873 11059 89834463
Cystitis haemorrhagic 12.11 9.98 18 782907 5495 89840027
Disturbance in social behaviour 12.08 9.98 11 782914 4177 89841345
Adverse drug reaction 12.07 9.98 1168 781757 115533 89729989
Product availability issue 12.02 9.98 29 782896 7375 89838147
Uterine perforation 11.94 9.98 30 782895 7524 89837998
Pathological fracture 11.94 9.98 43 782882 9617 89835905
Product physical issue 11.94 9.98 19 782906 5641 89839881
Inflammatory marker increased 11.93 9.98 127 782798 9087 89836435
Benign ovarian tumour 11.93 9.98 18 782907 485 89845037
Osteolysis 11.92 9.98 8 782917 3542 89841980
Blood potassium increased 11.92 9.98 118 782807 20631 89824891
Metastases to peritoneum 11.89 9.98 11 782914 4144 89841378
Ingrown hair 11.83 9.98 20 782905 595 89844927
Device deployment issue 11.82 9.98 15 782910 4894 89840628
Cholangitis 11.77 9.98 28 782897 7154 89838368
International normalised ratio fluctuation 11.76 9.98 6 782919 3087 89842435
Dermatitis contact 11.75 9.98 69 782856 13526 89831996
Catheter site erythema 11.74 9.98 15 782910 4879 89840643
Pancreatic steatosis 11.71 9.98 36 782889 1606 89843916
Cross sensitivity reaction 11.70 9.98 5 782920 2852 89842670
Dermatitis 11.69 9.98 129 782796 22091 89823431
Hyperreflexia 11.68 9.98 25 782900 6632 89838890
Intervertebral disc degeneration 11.67 9.98 212 782713 17062 89828460
Post procedural haemorrhage 11.66 9.98 38 782887 8760 89836762
Osteonecrosis 11.66 9.98 158 782767 26083 89819439
Implant site pain 11.65 9.98 4 782921 2608 89842914
Oligoarthritis 11.63 9.98 19 782906 549 89844973
Congenital cerebral cyst 11.63 9.98 13 782912 258 89845264
Exomphalos 11.60 9.98 19 782906 550 89844972
Immunosuppressant drug level increased 11.58 9.98 14 782911 4666 89840856
Clostridium difficile infection 11.56 9.98 232 782693 36013 89809509
Metabolic disorder 11.55 9.98 30 782895 7440 89838082
Hypotonia 11.54 9.98 55 782870 11371 89834151
Major depression 11.54 9.98 46 782879 9989 89835533
Cerebral haematoma 11.52 9.98 12 782913 4277 89841245
Lung transplant 11.51 9.98 9 782916 3683 89841839
Abnormal dreams 11.48 9.98 54 782871 11203 89834319
Cleft palate 11.47 9.98 31 782894 1285 89844237
Terminal state 11.43 9.98 5 782920 2813 89842709
Catheter site haemorrhage 11.36 9.98 9 782916 3659 89841863
Lip oedema 11.35 9.98 14 782911 4625 89840897
Intraocular pressure increased 11.35 9.98 28 782897 7065 89838457
Intestinal ischaemia 11.34 9.98 39 782886 8844 89836678
Blood loss anaemia 11.34 9.98 47 782878 10093 89835429
Hypertransaminasaemia 11.32 9.98 85 782840 15740 89829782
Pulmonary tuberculosis 11.27 9.98 76 782849 4758 89840764
Skin fissures 11.27 9.98 120 782805 20689 89824833
Neutrophil count increased 11.25 9.98 110 782815 19280 89826242
Learning disorder 11.23 9.98 24 782901 854 89844668
Bacterial infection 11.21 9.98 139 782786 23305 89822217
Sickle cell anaemia 11.20 9.98 20 782905 622 89844900
Ventricular hypokinesia 11.20 9.98 18 782907 5323 89840199
Ageusia 11.19 9.98 87 782838 15989 89829533
Inadequate analgesia 11.19 9.98 7 782918 3217 89842305
Respiratory disorder 11.15 9.98 452 782473 64364 89781158
Poor quality device used 11.15 9.98 3 782922 2290 89843232
Human anti-human antibody test 11.14 9.98 16 782909 412 89845110
Therapeutic response unexpected 11.12 9.98 128 782797 21752 89823770
Persecutory delusion 11.08 9.98 7 782918 3201 89842321
Cervical incompetence 11.07 9.98 20 782905 628 89844894
Pneumonia aspiration 11.06 9.98 269 782656 40671 89804851
Pneumonia fungal 11.06 9.98 28 782897 7003 89838519
Heparin-induced thrombocytopenia 11.04 9.98 18 782907 5294 89840228
Tendonitis 11.02 9.98 252 782673 21120 89824402
Wrong technique in device usage process 11.02 9.98 21 782904 5814 89839708
Skin cancer 10.99 9.98 171 782754 13348 89832174
Upper-airway cough syndrome 10.97 9.98 81 782844 15054 89830468
Cyst rupture 10.96 9.98 23 782902 808 89844714
Cardiac failure chronic 10.95 9.98 20 782905 5626 89839896
Total lung capacity decreased 10.91 9.98 10 782915 3785 89841737
Foetal distress syndrome 10.90 9.98 36 782889 1669 89843853
Productive cough 10.90 9.98 549 782376 76514 89769008
Blood parathyroid hormone decreased 10.90 9.98 157 782768 12059 89833463
Pulmonary function test abnormal 10.89 9.98 5 782920 2734 89842788
Sensitisation 10.86 9.98 12 782913 4163 89841359
Subacute cutaneous lupus erythematosus 10.83 9.98 9 782916 3573 89841949
Micturition urgency 10.81 9.98 55 782870 11178 89834344
Pulmonary toxicity 10.80 9.98 57 782868 11474 89834048
Immune-mediated hepatitis 10.77 9.98 6 782919 2938 89842584
Type I hypersensitivity 10.75 9.98 12 782913 4143 89841379
Drug screen positive 10.68 9.98 10 782915 3747 89841775
Skin swelling 10.67 9.98 26 782899 6588 89838934
Retinal haemorrhage 10.66 9.98 21 782904 5743 89839779
Granuloma skin 10.64 9.98 140 782785 10540 89834982
Ventricular arrhythmia 10.62 9.98 13 782912 4308 89841214
Metastases to spine 10.60 9.98 10 782915 3733 89841789
Flatulence 10.59 9.98 274 782651 41093 89804429
Immunisation 10.56 9.98 3 782922 2210 89843312
Lymph gland infection 10.56 9.98 18 782907 539 89844983
Blood calcium increased 10.53 9.98 61 782864 11997 89833525
Mental impairment 10.50 9.98 93 782832 16627 89828895
Hypocalcaemia 10.48 9.98 282 782643 42086 89803436
Device occlusion 10.39 9.98 43 782882 9239 89836283
Fracture 10.38 9.98 257 782668 21819 89823703
Cold sweat 10.37 9.98 75 782850 14006 89831516
Hypoglycaemia neonatal 10.35 9.98 27 782898 1095 89844427
Paranasal sinus discomfort 10.34 9.98 24 782901 6186 89839336
Colorectal cancer 10.34 9.98 11 782914 3882 89841640
Breast cancer stage II 10.33 9.98 388 782537 34946 89810576
Talipes 10.32 9.98 35 782890 1645 89843877
Anal incontinence 10.31 9.98 90 782835 16140 89829382
Facial pain 10.31 9.98 69 782856 13113 89832409
Foot operation 10.26 9.98 121 782804 8880 89836642
Cholecystitis acute 10.26 9.98 44 782881 9360 89836162
Wrong product administered 10.24 9.98 33 782892 7632 89837890
Joint warmth 10.21 9.98 36 782889 1726 89843796
Oral pain 10.18 9.98 210 782715 32473 89813049
Formication 10.18 9.98 16 782909 4775 89840747
Staphylococcal sepsis 10.18 9.98 44 782881 9339 89836183
Injection site warmth 10.15 9.98 210 782715 17305 89828217
Haemodialysis 10.12 9.98 40 782885 8707 89836815
Cell death 10.10 9.98 7 782918 3048 89842474
Hypochloraemia 10.10 9.98 5 782920 2617 89842905
Induced labour 10.07 9.98 25 782900 983 89844539
Decreased appetite 10.05 9.98 3001 779924 373539 89471983
Cardiac tamponade 10.01 9.98 21 782904 5611 89839911
Depressive symptom 10.00 9.98 19 782906 5266 89840256

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 660.44 10.32 935 213532 41505 42365363
Drug abuse 346.15 10.32 56 214411 104715 42302153
Foetal exposure during pregnancy 344.74 10.32 746 213721 46565 42360303
Toxicity to various agents 301.09 10.32 429 214038 228707 42178161
Psoriatic arthropathy 270.75 10.32 466 214001 24501 42382367
Arthralgia 261.63 10.32 1848 212619 203390 42203478
Completed suicide 244.10 10.32 90 214377 96375 42310493
Drug interaction 191.40 10.32 695 213772 266304 42140564
Psoriasis 155.42 10.32 568 213899 48036 42358832
Sickle cell anaemia with crisis 154.91 10.32 155 214312 4735 42402133
Joint swelling 150.64 10.32 710 213757 67312 42339556
Dysmorphism 141.42 10.32 124 214343 3192 42403676
Intentional overdose 126.80 10.32 50 214417 51406 42355462
Arthritis 113.57 10.32 466 214001 41599 42365269
Product use in unapproved indication 111.99 10.32 512 213955 183944 42222924
Musculoskeletal stiffness 111.55 10.32 580 213887 57185 42349683
Pain 107.68 10.32 1780 212687 243068 42163800
Synovitis 103.78 10.32 237 214230 15330 42391538
Blood pressure fluctuation 102.16 10.32 333 214134 26575 42380293
Premature baby 98.45 10.32 298 214169 22855 42384013
Enthesopathy 95.99 10.32 120 214347 4708 42402160
Blood pressure systolic increased 92.91 10.32 331 214136 27637 42379231
Small for dates baby 92.39 10.32 123 214344 5140 42401728
Off label use 91.86 10.32 2480 211987 635855 41771013
Arthropathy 86.39 10.32 336 214131 29261 42377607
Exposure during pregnancy 85.46 10.32 154 214313 8394 42398474
Hepatic function abnormal 83.09 10.32 82 214385 51485 42355383
Coma 83.07 10.32 88 214379 53466 42353402
Tenosynovitis 81.31 10.32 109 214358 4586 42402282
C-reactive protein abnormal 79.11 10.32 156 214311 9105 42397763
Acute kidney injury 78.65 10.32 1338 213129 365999 42040869
Death 78.34 10.32 1791 212676 469394 41937474
Blood pressure systolic abnormal 77.48 10.32 116 214351 5412 42401456
Disease progression 76.68 10.32 417 214050 143239 42263629
Serotonin syndrome 74.53 10.32 19 214448 25826 42381042
Rhabdomyolysis 72.33 10.32 180 214287 77839 42329029
Speech disorder developmental 71.59 10.32 72 214395 2213 42404655
Neonatal respiratory distress syndrome 69.49 10.32 99 214368 4414 42402454
Overdose 66.95 10.32 287 214180 104977 42301891
Maternal exposure during pregnancy 66.33 10.32 123 214344 6855 42400013
Blood pressure diastolic abnormal 65.91 10.32 114 214353 6014 42400854
Drug resistance 65.61 10.32 46 214421 34202 42372666
Foetal anticonvulsant syndrome 63.79 10.32 51 214416 1151 42405717
Sedation 63.77 10.32 37 214430 30438 42376430
Low birth weight baby 62.45 10.32 148 214319 9807 42397061
Multiple organ dysfunction syndrome 61.44 10.32 265 214202 96770 42310098
Drug dependence 61.34 10.32 35 214432 29059 42377809
Pancytopenia 61.21 10.32 881 213586 116862 42290006
Intentional product misuse 61.21 10.32 138 214329 61762 42345106
Weight decreased 61.19 10.32 1423 213044 206525 42200343
Osteoarthritis 57.87 10.32 260 214207 24145 42382723
Suicide attempt 57.76 10.32 89 214378 46011 42360857
Heart rate decreased 57.35 10.32 347 214120 36185 42370683
Alanine aminotransferase abnormal 57.18 10.32 95 214372 4849 42402019
Hypoglycaemia neonatal 57.07 10.32 62 214405 2088 42404780
Hypospadias 54.55 10.32 78 214389 3489 42403379
Maternal drugs affecting foetus 54.44 10.32 81 214386 3758 42403110
Atrial septal defect 54.38 10.32 122 214345 7797 42399071
Peripheral swelling 52.84 10.32 690 213777 89580 42317288
Learning disorder 52.30 10.32 44 214423 1069 42405799
Febrile neutropenia 51.28 10.32 643 213824 185060 42221808
Blood pressure diastolic decreased 50.33 10.32 140 214327 10235 42396633
Nasopharyngitis 49.98 10.32 644 213823 83352 42323516
Appendicolith 49.69 10.32 5 214462 13451 42393417
Autism spectrum disorder 49.66 10.32 68 214399 2920 42403948
Cryptorchism 49.57 10.32 56 214411 1971 42404897
Joint effusion 48.77 10.32 98 214369 5799 42401069
Angioedema 48.58 10.32 87 214380 42390 42364478
Pain in extremity 48.47 10.32 1044 213423 149560 42257308
Rheumatoid nodule 48.04 10.32 67 214400 2928 42403940
Palmar-plantar erythrodysaesthesia syndrome 47.50 10.32 22 214445 20560 42386308
Drug ineffective for unapproved indication 47.21 10.32 101 214366 46062 42360806
Jaundice neonatal 44.67 10.32 55 214412 2124 42404744
Sleep disorder due to a general medical condition 44.59 10.32 16 214451 17437 42389431
Altered state of consciousness 44.34 10.32 49 214418 29210 42377658
Poisoning 43.96 10.32 10 214457 14689 42392179
Ventricular septal defect 43.65 10.32 79 214388 4320 42402548
Colitis ulcerative 43.25 10.32 252 214215 25923 42380945
Blood pressure diastolic increased 43.22 10.32 98 214369 6307 42400561
Haemoglobin decreased 43.17 10.32 920 213547 131551 42275317
Inflammation 41.91 10.32 303 214164 33544 42373324
Bradycardia 41.89 10.32 255 214212 85229 42321639
Syndactyly 41.83 10.32 36 214431 903 42405965
Haematochezia 41.77 10.32 464 214003 57972 42348896
Tongue disorder 41.61 10.32 87 214380 5296 42401572
Grip strength decreased 41.57 10.32 69 214398 3519 42403349
Maternal exposure during breast feeding 41.55 10.32 45 214422 1510 42405358
Body temperature decreased 41.55 10.32 163 214304 14250 42392618
Blood pressure increased 41.39 10.32 732 213735 101196 42305672
Infusion related reaction 41.29 10.32 478 213989 60328 42346540
No adverse event 41.06 10.32 84 214383 38937 42367931
Suicidal ideation 40.92 10.32 116 214351 48045 42358823
Drug ineffective 40.90 10.32 2679 211788 627518 41779350
Hand deformity 40.40 10.32 70 214397 3698 42403170
Knee arthroplasty 40.16 10.32 116 214351 8665 42398203
Cytomegalovirus infection 39.87 10.32 63 214404 32243 42374625
Cytokine release syndrome 39.51 10.32 105 214362 44422 42362446
Foot deformity 39.28 10.32 82 214385 4986 42401882
Drug reaction with eosinophilia and systemic symptoms 39.04 10.32 97 214370 41978 42364890
Depressed level of consciousness 38.97 10.32 118 214349 47852 42359016
Myelosuppression 38.55 10.32 92 214375 40369 42366499
Pathogen resistance 38.05 10.32 6 214461 11444 42395424
Exposure via breast milk 37.64 10.32 54 214413 2423 42404445
Neuroleptic malignant syndrome 37.12 10.32 32 214435 21440 42385428
Abdominal discomfort 36.69 10.32 557 213910 74698 42332170
Cardiogenic shock 36.42 10.32 78 214389 35562 42371306
Joint laxity 36.12 10.32 24 214443 402 42406466
Toxic epidermal necrolysis 36.11 10.32 49 214418 26701 42380167
Red blood cell sedimentation rate increased 36.04 10.32 121 214346 9803 42397065
C-reactive protein increased 36.00 10.32 483 213984 63077 42343791
Foetal growth restriction 35.84 10.32 81 214386 5202 42401666
Sopor 35.66 10.32 11 214456 13191 42393677
Cardiac murmur 35.63 10.32 143 214324 12632 42394236
Lower respiratory tract infection 35.54 10.32 340 214127 40866 42366002
Polyarthritis 34.34 10.32 78 214389 5026 42401842
Malignant neoplasm progression 34.31 10.32 364 214103 108036 42298832
Bradycardia neonatal 34.27 10.32 38 214429 1310 42405558
Lactic acidosis 34.20 10.32 115 214352 45146 42361722
Ventricular fibrillation 34.17 10.32 62 214405 30061 42376807
Anal fissure 34.07 10.32 79 214388 5160 42401708
Developmental delay 33.97 10.32 59 214408 3123 42403745
Respiratory arrest 33.61 10.32 57 214410 28367 42378501
Wound 33.11 10.32 172 214295 16945 42389923
Drug use disorder 33.04 10.32 6 214461 10327 42396541
Respiratory disorder neonatal 32.99 10.32 45 214422 1925 42404943
Renal impairment 32.95 10.32 375 214092 109853 42297015
Acute hepatic failure 32.61 10.32 23 214444 17050 42389818
Acute chest syndrome 32.35 10.32 33 214434 1032 42405836
Catarrh 32.28 10.32 84 214383 5902 42400966
Drug withdrawal syndrome neonatal 32.07 10.32 70 214397 4391 42402477
Basal cell carcinoma 31.99 10.32 210 214257 22523 42384345
Tendonitis 31.92 10.32 116 214351 9778 42397090
Anaphylactic shock 30.82 10.32 44 214423 23473 42383395
Plagiocephaly 30.80 10.32 25 214442 577 42406291
Caesarean section 30.67 10.32 45 214422 2061 42404807
Psychotic disorder 30.62 10.32 63 214404 29145 42377723
Cardiac failure 30.59 10.32 367 214100 106489 42300379
Talipes 30.03 10.32 46 214421 2190 42404678
Delirium 29.92 10.32 149 214318 52370 42354498
Finger deformity 29.92 10.32 39 214428 1596 42405272
Fatigue 29.91 10.32 2562 211905 433079 41973789
Dysgraphia 29.81 10.32 49 214418 2479 42404389
Hypermobility syndrome 29.69 10.32 20 214447 343 42406525
Hypoglycaemia 29.60 10.32 178 214289 59676 42347192
Pulmonary alveolar haemorrhage 29.59 10.32 19 214448 14797 42392071
Shock 29.53 10.32 64 214403 29057 42377811
Mucocutaneous ulceration 29.49 10.32 23 214444 500 42406368
Neurotoxicity 29.30 10.32 46 214421 23605 42383263
Musculoskeletal pain 29.20 10.32 276 214191 33064 42373804
Congenital hand malformation 28.99 10.32 25 214442 629 42406239
Substance abuse 28.85 10.32 5 214462 8900 42397968
Large for dates baby 28.58 10.32 29 214438 901 42405967
Agitation 28.38 10.32 198 214269 64116 42342752
Burns second degree 28.33 10.32 81 214386 6015 42400853
Ankylosing spondylitis 28.30 10.32 89 214378 6967 42399901
Immune reconstitution inflammatory syndrome 28.22 10.32 8 214459 10135 42396733
Frequent bowel movements 27.87 10.32 194 214273 21213 42385655
Cardiac arrest 27.77 10.32 385 214082 108935 42297933
Forced expiratory volume decreased 27.75 10.32 3 214464 7627 42399241
Joint range of motion decreased 27.68 10.32 94 214373 7659 42399209
Haematocrit decreased 27.65 10.32 283 214184 34625 42372243
Agitation neonatal 27.60 10.32 35 214432 1393 42405475
Electrocardiogram QT prolonged 27.33 10.32 136 214331 47809 42359059
Systemic lupus erythematosus 27.32 10.32 106 214361 9218 42397650
Intentional self-injury 27.09 10.32 22 214445 15180 42391688
Venoocclusive liver disease 27.09 10.32 9 214458 10293 42396575
Aspergillus infection 26.90 10.32 24 214443 15813 42391055
Therapy partial responder 26.69 10.32 37 214430 19984 42386884
Therapeutic product effect decreased 26.67 10.32 308 214159 38842 42368026
Diaphragmatic disorder 26.58 10.32 32 214435 1207 42405661
Language disorder 26.56 10.32 46 214421 2429 42404439
Respiratory failure 26.56 10.32 469 213998 127663 42279205
Tuberculosis 26.55 10.32 111 214356 9988 42396880
BK virus infection 26.22 10.32 6 214461 8778 42398090
Respiratory depression 26.04 10.32 34 214433 18834 42388034
Akathisia 25.99 10.32 10 214457 10441 42396427
Hypokalaemia 25.98 10.32 233 214234 71488 42335380
Ultrasound antenatal screen 25.89 10.32 22 214445 542 42406326
Renal failure 25.83 10.32 539 213928 143187 42263681
Post transplant lymphoproliferative disorder 25.73 10.32 7 214460 9113 42397755
Cytomegalovirus infection reactivation 25.71 10.32 12 214455 11166 42395702
Appendicitis 25.62 10.32 40 214427 20573 42386295
Hyperglycaemia 25.61 10.32 131 214336 45728 42361140
Hydrops foetalis 25.61 10.32 27 214440 878 42405990
Mucormycosis 25.50 10.32 3 214464 7140 42399728
Wrong technique in product usage process 25.42 10.32 119 214348 42516 42364352
Hepatic failure 25.37 10.32 102 214365 37998 42368870
Foetal disorder 25.02 10.32 29 214438 1050 42405818
Skin cancer 24.88 10.32 119 214348 11343 42395525
Trisomy 18 24.82 10.32 26 214441 839 42406029
Arthritis infective 24.63 10.32 60 214407 4046 42402822
Localised infection 24.43 10.32 181 214286 20192 42386676
Drug intolerance 24.41 10.32 553 213914 79871 42326997
Somnolence 23.96 10.32 534 213933 140571 42266297
Parosmia 23.82 10.32 89 214378 7602 42399266
Nasal disorder 23.77 10.32 39 214428 1970 42404898
Gingival pain 23.63 10.32 95 214372 8399 42398469
Maternal exposure before pregnancy 23.40 10.32 28 214439 1049 42405819
Selective eating disorder 23.28 10.32 36 214431 1728 42405140
Astigmatism 23.20 10.32 31 214436 1300 42405568
Hyperbilirubinaemia neonatal 23.08 10.32 25 214442 839 42406029
Lung neoplasm malignant 22.89 10.32 170 214297 18977 42387891
Dyspraxia 22.85 10.32 19 214448 454 42406414
Anal fistula 22.78 10.32 76 214391 6137 42400731
Joint stiffness 22.59 10.32 122 214345 12200 42394668
Blood phosphorus increased 22.47 10.32 18 214449 12507 42394361
Radiation inflammation 22.37 10.32 27 214440 1021 42405847
Tachycardia 22.24 10.32 366 214101 100721 42306147
Vitamin D deficiency 22.22 10.32 90 214377 7983 42398885
Drug withdrawal syndrome 22.15 10.32 47 214420 21502 42385366
Withdrawal syndrome 22.11 10.32 25 214442 14750 42392118
Hypotonia neonatal 22.04 10.32 32 214435 1452 42405416
Temperature regulation disorder 21.76 10.32 28 214439 1131 42405737
Adenovirus infection 21.67 10.32 4 214463 6805 42400063
Crohn's disease 21.65 10.32 47 214420 2937 42403931
Knee deformity 21.62 10.32 23 214444 756 42406112
Oxygen saturation decreased 21.61 10.32 451 214016 64236 42342632
Motor developmental delay 21.54 10.32 22 214445 689 42406179
Cleft lip and palate 21.53 10.32 25 214442 907 42405961
Arthrodesis 21.38 10.32 20 214447 561 42406307
Umbilical hernia 21.20 10.32 68 214399 5379 42401489
Suspected suicide 21.17 10.32 3 214464 6196 42400672
Serum ferritin increased 21.10 10.32 82 214385 7137 42399731
Steroid dependence 21 10.32 78 214389 6644 42400224
Post procedural infection 20.53 10.32 70 214397 5715 42401153
Dyslexia 20.36 10.32 16 214451 352 42406516
Thymus disorder 20.35 10.32 14 214453 249 42406619
Hypopnoea 20.23 10.32 86 214381 7796 42399072
Acute graft versus host disease 20.20 10.32 8 214459 8207 42398661
Rebound effect 20.20 10.32 6 214461 7373 42399495
Transient aphasia 20.04 10.32 20 214447 609 42406259
Ankyloglossia congenital 19.98 10.32 16 214451 362 42406506
Central nervous system mass 19.95 10.32 23 214444 828 42406040
Loss of personal independence in daily activities 19.93 10.32 357 214110 49459 42357409
Congenital foot malformation 19.90 10.32 17 214450 422 42406446
Wall motion score index abnormal 19.86 10.32 23 214444 832 42406036
Hypoxia 19.84 10.32 240 214227 69546 42337322
Cellulitis 19.80 10.32 427 214040 61158 42345710
Proteinuria 19.78 10.32 55 214412 22928 42383940
Congenital anomaly 19.71 10.32 31 214436 1510 42405358
Influenza 19.65 10.32 430 214037 61745 42345123
Intellectual disability 19.62 10.32 35 214432 1892 42404976
Ear disorder 19.59 10.32 36 214431 1992 42404876
Metabolic acidosis 19.43 10.32 167 214300 51691 42355177
Spinal disorder 19.43 10.32 59 214408 4532 42402336
Cardiac septal defect 19.31 10.32 24 214443 936 42405932
Pruritus 19.15 10.32 766 213701 188005 42218863
Aggression 18.97 10.32 137 214330 44026 42362842
Fall 18.93 10.32 1397 213070 233123 42173745
Airway remodelling 18.91 10.32 23 214444 877 42405991
Incorrect route of product administration 18.88 10.32 61 214406 24244 42382624
Intervertebral disc degeneration 18.61 10.32 80 214387 7287 42399581
Synovial cyst 18.61 10.32 41 214426 2588 42404280
Red blood cell sedimentation rate 18.59 10.32 25 214442 1055 42405813
Polyomavirus-associated nephropathy 18.53 10.32 3 214464 5612 42401256
Cytomegalovirus viraemia 18.51 10.32 15 214452 10362 42396506
Weight increased 18.51 10.32 691 213776 107292 42299576
Headache 18.50 10.32 1421 213046 237948 42168920
Syringe issue 18.46 10.32 10 214457 8546 42398322
Medical device implantation 18.42 10.32 19 214448 602 42406266
Transfusion-related circulatory overload 18.39 10.32 21 214446 748 42406120
Spina bifida 18.37 10.32 16 214451 408 42406460
Rhinitis 18.31 10.32 113 214354 11864 42395004
Haemolysis 18.30 10.32 96 214371 9493 42397375
Arthritis bacterial 18.26 10.32 68 214399 5800 42401068
Cystitis haemorrhagic 18.25 10.32 7 214460 7322 42399546
Blood parathyroid hormone decreased 18.24 10.32 31 214436 1612 42405256
Multiple congenital abnormalities 18.20 10.32 18 214449 542 42406326
Fistula discharge 18.09 10.32 25 214442 1083 42405785
Renal aplasia 18.08 10.32 21 214446 762 42406106
Squamous cell carcinoma of lung 18.07 10.32 37 214430 2219 42404649
Infection 17.99 10.32 712 213755 111356 42295512
Blood creatine phosphokinase increased 17.96 10.32 156 214311 48182 42358686
Malignant melanoma 17.86 10.32 94 214373 9306 42397562
Oropharyngeal pain 17.85 10.32 307 214160 42203 42364665
Ear infection 17.84 10.32 118 214349 12686 42394182
Joint ankylosis 17.78 10.32 31 214436 1646 42405222
Pulmonary fibrosis 17.77 10.32 209 214258 26472 42380396
Drug dose omission by device 17.61 10.32 4 214463 5882 42400986
Cleft lip 17.58 10.32 14 214453 314 42406554
Sinusitis 17.56 10.32 335 214132 46957 42359911
Atopy 17.44 10.32 23 214444 952 42405916
Alcohol poisoning 17.44 10.32 80 214387 7494 42399374
Limb reduction defect 17.43 10.32 14 214453 318 42406550
Accidental exposure to product 17.40 10.32 49 214418 20344 42386524
Lacrimal disorder 17.36 10.32 14 214453 320 42406548
Pulmonary vasculitis 17.32 10.32 5 214462 6261 42400607
Anti-cyclic citrullinated peptide antibody positive 17.30 10.32 33 214434 1879 42404989
Pneumonia 17.23 10.32 2399 212068 419750 41987118
Congenital bladder anomaly 17.21 10.32 13 214454 269 42406599
Otitis media 17.18 10.32 49 214418 3634 42403234
Cardiotoxicity 17.11 10.32 8 214459 7437 42399431
Weight decrease neonatal 17.10 10.32 14 214453 327 42406541
Hepatic steatosis 17.04 10.32 174 214293 21274 42385594
Acute graft versus host disease in skin 17.03 10.32 8 214459 7416 42399452
Back disorder 17.03 10.32 79 214388 7435 42399433
Vitamin B12 deficiency 16.98 10.32 59 214408 4863 42402005
Granuloma skin 16.96 10.32 25 214442 1150 42405718
Patent ductus arteriosus 16.95 10.32 47 214420 3429 42403439
Ventricular tachycardia 16.93 10.32 86 214381 30074 42376794
Haemangioma congenital 16.92 10.32 17 214450 522 42406346
Hydrocele 16.85 10.32 39 214428 2544 42404324
Osteonecrosis of jaw 16.83 10.32 45 214422 19004 42387864
Constipation 16.79 10.32 657 213810 161634 42245234
Upper respiratory tract infection 16.79 10.32 302 214165 41871 42364997
Posterior reversible encephalopathy syndrome 16.79 10.32 24 214443 12797 42394071
Pneumonia aspiration 16.72 10.32 166 214301 49912 42356956
Hypertelorism 16.69 10.32 18 214449 601 42406267
Pectus excavatum 16.67 10.32 12 214455 230 42406638
Ascites 16.47 10.32 194 214273 56484 42350384
Cerebral haemorrhage 16.20 10.32 122 214345 38844 42368024
Heart rate irregular 16.17 10.32 137 214330 15913 42390955
Disseminated intravascular coagulation 16.12 10.32 67 214400 24727 42382141
Sexual dysfunction 16.01 10.32 7 214460 6768 42400100
Vomiting 15.99 10.32 1248 213219 288475 42118393
Mite allergy 15.99 10.32 3 214464 5043 42401825
Neurological symptom 15.96 10.32 16 214451 9975 42396893
Red blood cell sedimentation rate abnormal 15.95 10.32 49 214418 3787 42403081
Colorectal cancer 15.95 10.32 3 214464 5035 42401833
Device leakage 15.83 10.32 17 214450 10268 42396600
Exposure to toxic agent 15.80 10.32 3 214464 5001 42401867
Immunosuppression 15.70 10.32 84 214383 8369 42398499
Injection site haemorrhage 15.66 10.32 107 214360 11629 42395239
Neck mass 15.60 10.32 31 214436 1819 42405049
Bone cyst 15.56 10.32 29 214438 1622 42405246
Red blood cell count decreased 15.49 10.32 241 214226 32474 42374394
Spondyloarthropathy 15.49 10.32 21 214446 893 42405975
Dermatitis atopic 15.48 10.32 24 214443 12380 42394488
Electrocardiogram QRS complex prolonged 15.46 10.32 5 214462 5818 42401050
Neutropenia neonatal 15.38 10.32 21 214446 899 42405969
Septic arthritis staphylococcal 15.36 10.32 16 214451 513 42406355
Loss of consciousness 15.24 10.32 351 214116 92003 42314865
Juvenile idiopathic arthritis 15.23 10.32 38 214429 2601 42404267
Pulmonary pain 15.23 10.32 28 214439 1550 42405318
Skin injury 15.22 10.32 38 214429 2603 42404265
Microangiopathy 15.18 10.32 29 214438 1653 42405215
Bursitis 15.16 10.32 67 214400 6177 42400691
Abortion spontaneous 15.05 10.32 14 214453 390 42406478
Carcinoid tumour of the small bowel 14.90 10.32 14 214453 395 42406473
Asphyxia 14.89 10.32 12 214455 8314 42398554
C-reactive protein decreased 14.85 10.32 34 214433 2202 42404666
Mobility decreased 14.83 10.32 255 214212 35051 42371817
Contusion 14.77 10.32 295 214172 41690 42365178
Cholelithiasis 14.73 10.32 181 214286 23165 42383703
Polydactyly 14.66 10.32 24 214443 1210 42405658
Disability assessment scale score increased 14.64 10.32 14 214453 404 42406464
Acute respiratory distress syndrome 14.64 10.32 90 214377 30018 42376850
Agranulocytosis 14.63 10.32 92 214375 30520 42376348
Gastrointestinal infection 14.63 10.32 70 214397 6673 42400195
Oesophageal fibrosis 14.62 10.32 10 214457 176 42406692
Chronic graft versus host disease 14.60 10.32 6 214461 6019 42400849
Dysstasia 14.60 10.32 121 214346 13965 42392903
Myoclonus 14.57 10.32 41 214426 17024 42389844
Bronchiolitis 14.52 10.32 48 214419 3858 42403010
Hernia pain 14.49 10.32 12 214455 285 42406583
Neoplasm progression 14.46 10.32 86 214381 28914 42377954
Tooth malformation 14.38 10.32 10 214457 181 42406687
Obsessive-compulsive disorder 14.37 10.32 8 214459 6735 42400133
Glycosylated haemoglobin increased 14.30 10.32 27 214440 12897 42393971
Hypocalcaemia 14.26 10.32 91 214376 30082 42376786
Respiratory rate increased 14.25 10.32 100 214367 10962 42395906
Hypertriglyceridaemia 14.23 10.32 18 214449 10108 42396760
Neck pain 14.17 10.32 221 214246 29793 42377075
Attention deficit hyperactivity disorder 14.16 10.32 41 214426 3067 42403801
Urticaria 14.08 10.32 275 214192 73761 42333107
Low set ears 14.08 10.32 15 214452 494 42406374
Cytomegalovirus chorioretinitis 14.07 10.32 3 214464 4608 42402260
Diverticulum 14.05 10.32 75 214392 7466 42399402
Foetal distress syndrome 14.00 10.32 23 214444 1163 42405705
Drug level increased 13.98 10.32 76 214391 26124 42380744
Nephropathy toxic 13.97 10.32 41 214426 16797 42390071
Exposure via skin contact 13.97 10.32 4 214463 5034 42401834
Lung opacity 13.84 10.32 6 214461 5831 42401037
Blister infected 13.72 10.32 15 214452 509 42406359
Impaired work ability 13.69 10.32 106 214361 11985 42394883
Respiratory tract infection viral 13.69 10.32 43 214424 3363 42403505
Microcephaly 13.67 10.32 20 214447 914 42405954
Hepatic enzyme increased 13.63 10.32 314 214153 45470 42361398
Myasthenia gravis 13.60 10.32 39 214428 16098 42390770
Arnold-Chiari malformation 13.60 10.32 13 214454 375 42406493
Autoscopy 13.58 10.32 11 214456 253 42406615
Maternal exposure timing unspecified 13.54 10.32 13 214454 377 42406491
Hepatitis E antibody positive 13.47 10.32 11 214456 256 42406612
Hyponatraemia 13.46 10.32 398 214069 101064 42305804
Back pain 13.43 10.32 856 213611 140920 42265948
Hypertransaminasaemia 13.39 10.32 16 214451 9211 42397657
Potentiating drug interaction 13.32 10.32 8 214459 6460 42400408
Gangrene neonatal 13.32 10.32 10 214457 205 42406663
Endophthalmitis 13.29 10.32 3 214464 4430 42402438
Cystitis bacterial 13.28 10.32 10 214457 206 42406662
Lung cancer metastatic 13.23 10.32 39 214428 2947 42403921
Diverticular perforation 13.22 10.32 45 214422 3671 42403197
Euglycaemic diabetic ketoacidosis 13.14 10.32 6 214461 5654 42401214
Scoliosis 13.06 10.32 40 214427 3086 42403782
Haemoptysis 13.03 10.32 159 214308 46008 42360860
Haematotoxicity 13.01 10.32 22 214445 10963 42395905
Haemangioma 12.98 10.32 30 214437 1955 42404913
Hepatic encephalopathy 12.95 10.32 41 214426 16401 42390467
Fistula 12.95 10.32 76 214391 7836 42399032
Dry throat 12.95 10.32 38 214429 2864 42404004
Mydriasis 12.95 10.32 15 214452 8755 42398113
Asthma 12.93 10.32 228 214239 62086 42344782
Bone erosion 12.85 10.32 50 214417 4353 42402515
Anaemia vitamin B12 deficiency 12.83 10.32 15 214452 548 42406320
Eosinophilic myocarditis 12.80 10.32 24 214443 1349 42405519
Pleural fibrosis 12.78 10.32 24 214443 1350 42405518
Strabismus 12.71 10.32 33 214434 2315 42404553
Ligament rupture 12.71 10.32 24 214443 1356 42405512
Melaena 12.70 10.32 129 214338 38617 42368251
Rash maculo-papular 12.65 10.32 124 214343 37379 42369489
Anal atresia 12.61 10.32 11 214456 281 42406587
Developmental coordination disorder 12.57 10.32 10 214457 224 42406644
Multiple-drug resistance 12.55 10.32 11 214456 7311 42399557
Lower respiratory tract congestion 12.53 10.32 26 214441 1574 42405294
Educational problem 12.52 10.32 15 214452 563 42406305
Foetal heart rate deceleration abnormality 12.49 10.32 15 214452 564 42406304
Pharyngitis 12.43 10.32 82 214385 8808 42398060
Asymptomatic bacteriuria 12.42 10.32 10 214457 228 42406640
Psychiatric decompensation 12.37 10.32 3 214464 4219 42402649
Vascular insufficiency 12.36 10.32 12 214455 353 42406515
Inguinal hernia 12.34 10.32 82 214385 8830 42398038
Thrombotic microangiopathy 12.26 10.32 36 214431 14746 42392122
Blood albumin decreased 12.26 10.32 125 214342 15277 42391591
Pleuritic pain 12.25 10.32 69 214398 7008 42399860
Blood insulin increased 12.25 10.32 12 214455 357 42406511
Dystonia 12.24 10.32 29 214438 12761 42394107
Gross motor delay 12.20 10.32 12 214455 359 42406509
Abdominal adhesions 12.14 10.32 27 214440 1715 42405153
Hyperammonaemia 12.11 10.32 13 214454 7853 42399015
Hepatitis E virus test positive 12.11 10.32 11 214456 297 42406571
Hypermetropia 12.10 10.32 14 214453 506 42406362
Poor venous access 12.09 10.32 70 214397 7182 42399686
Psychomotor retardation 12.08 10.32 49 214418 4350 42402518
Hallucination 12.06 10.32 210 214257 57297 42349571
Nephrolithiasis 12.04 10.32 256 214211 36574 42370294
Nerve compression 11.97 10.32 46 214421 3982 42402886
Infective pulmonary exacerbation of cystic fibrosis 11.95 10.32 13 214454 7805 42399063
Rotator cuff syndrome 11.93 10.32 65 214402 6521 42400347
Immunodeficiency 11.92 10.32 70 214397 7220 42399648
Hepatitis fulminant 11.92 10.32 5 214462 4954 42401914
Blood test abnormal 11.88 10.32 108 214359 12798 42394070
Vein disorder 11.85 10.32 30 214437 2072 42404796
Muscle twitching 11.85 10.32 26 214441 11754 42395114
Pyrexia 11.84 10.32 1771 212696 392271 42014597
Latent tuberculosis 11.82 10.32 26 214441 1639 42405229
Unresponsive to stimuli 11.82 10.32 101 214366 31302 42375566
Mucosal ulceration 11.80 10.32 23 214444 1331 42405537
Nail bed bleeding 11.80 10.32 13 214454 445 42406423
Skin abrasion 11.79 10.32 76 214391 8099 42398769
Blood folate increased 11.75 10.32 11 214456 309 42406559
Nephrotic syndrome 11.73 10.32 16 214451 8702 42398166
Peripheral artery thrombosis 11.73 10.32 35 214432 2662 42404206
Palindromic rheumatism 11.72 10.32 9 214458 191 42406677
Mania 11.70 10.32 22 214445 10525 42396343
Haemodynamic instability 11.60 10.32 29 214438 12528 42394340
Congenital hydronephrosis 11.56 10.32 17 214450 780 42406088
Tinnitus 11.44 10.32 207 214260 28731 42378137
Disease recurrence 11.37 10.32 95 214372 29583 42377285
Myopia 11.33 10.32 22 214445 1269 42405599
Swollen joint count decreased 11.32 10.32 10 214457 260 42406608
Tender joint count decreased 11.32 10.32 10 214457 260 42406608
Tinea pedis 11.31 10.32 29 214438 2019 42404849
Hypothyroidism 11.28 10.32 105 214362 31979 42374889
Psychomotor skills impaired 11.27 10.32 54 214413 5150 42401718
Fever neonatal 11.27 10.32 8 214459 150 42406718
Protein deficiency 11.26 10.32 10 214457 262 42406606
Stress ulcer 11.19 10.32 10 214457 264 42406604
Dehiscence 11.19 10.32 15 214452 631 42406237
Panniculitis 11.14 10.32 30 214437 2151 42404717
Bronchopulmonary aspergillosis 11.13 10.32 55 214412 19374 42387494
Drug-induced liver injury 11.12 10.32 131 214336 38142 42368726
Cardio-respiratory arrest 11.09 10.32 218 214249 58418 42348450
Excessive cerumen production 11.07 10.32 11 214456 333 42406535
Hallucination, auditory 11.07 10.32 38 214429 14826 42392042
Hand fracture 11.06 10.32 36 214431 2870 42403998
Osteochondrosis 11.06 10.32 23 214444 1395 42405473
Hypophosphataemia 11.04 10.32 61 214406 20884 42385984
Skin graft failure 11.04 10.32 8 214459 155 42406713
Anal spasm 11.04 10.32 8 214459 155 42406713
Palmoplantar pustulosis 10.97 10.32 13 214454 482 42406386
Disinhibition 10.97 10.32 3 214464 3892 42402976
Congenital genital malformation 10.95 10.32 8 214459 157 42406711
Stevens-Johnson syndrome 10.94 10.32 66 214401 22112 42384756
Rectal haemorrhage 10.93 10.32 327 214140 49279 42357589
Bronchitis 10.91 10.32 313 214154 46888 42359980
Abnormal behaviour 10.91 10.32 83 214384 26368 42380500
Emphysema 10.87 10.32 99 214368 11736 42395132
Ear malformation 10.86 10.32 11 214456 341 42406527
Gait disturbance 10.85 10.32 600 213867 97400 42309468
Vitamin B complex deficiency 10.82 10.32 13 214454 489 42406379
Visuospatial deficit 10.81 10.32 7 214460 112 42406756
Glomerular filtration rate decreased 10.74 10.32 44 214423 16307 42390561
Hip arthroplasty 10.74 10.32 54 214413 5251 42401617
Non-Hodgkin's lymphoma 10.74 10.32 23 214444 1424 42405444
Facial pain 10.72 10.32 4 214463 4256 42402612
Kyphosis 10.71 10.32 22 214445 1322 42405546
Encephalopathy 10.69 10.32 145 214322 41188 42365680
Brain oedema 10.69 10.32 44 214423 16283 42390585
Fine motor skill dysfunction 10.65 10.32 30 214437 2209 42404659
Dry mouth 10.64 10.32 139 214328 39740 42367128
Necrotising fasciitis streptococcal 10.62 10.32 8 214459 165 42406703
Restlessness 10.60 10.32 95 214372 29154 42377714
Mutism 10.58 10.32 23 214444 1439 42405429
Nail pitting 10.54 10.32 12 214455 426 42406442
PCO2 decreased 10.53 10.32 26 214441 1768 42405100
Blood homocysteine increased 10.50 10.32 10 214457 287 42406581
Complications of transplanted kidney 10.49 10.32 7 214460 5343 42401525
Haemoglobinuria 10.49 10.32 15 214452 671 42406197
Kidney infection 10.43 10.32 64 214403 6706 42400162
Lung neoplasm 10.41 10.32 49 214418 4639 42402229
Meningeal disorder 10.40 10.32 11 214456 359 42406509
Mesothelioma 10.39 10.32 12 214455 433 42406435
Bone hypertrophy 10.36 10.32 10 214457 292 42406576
Hyperkalaemia 10.33 10.32 317 214150 80141 42326727

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Systemic lupus erythematosus 1194.62 9.96 4246 780684 250092 109554277
Completed suicide 1189.04 9.96 157 784773 242224 109562145
Toxicity to various agents 1181.46 9.96 1005 783925 479550 109324819
Arthropathy 1139.80 9.96 4546 780384 282976 109521393
Synovitis 1104.40 9.96 4356 780574 269736 109534633
Pemphigus 1097.96 9.96 3686 781244 210884 109593485
Hand deformity 1077.99 9.96 3708 781222 214798 109589571
Joint swelling 1021.06 9.96 5990 778940 436855 109367514
Glossodynia 992.84 9.96 3648 781282 218356 109586013
Anti-cyclic citrullinated peptide antibody positive 860.78 9.96 3046 781884 178938 109625431
Wound 854.68 9.96 3613 781317 230824 109573545
Rheumatoid arthritis 838.25 9.96 4273 780657 295340 109509029
Pericarditis 825.40 9.96 3411 781519 215703 109588666
Drug abuse 799.42 9.96 146 784784 177265 109627104
Maternal exposure during pregnancy 761.64 9.96 3704 781226 251179 109553190
Duodenal ulcer perforation 741.12 9.96 2856 782074 174844 109629525
Drug interaction 730.71 9.96 1535 783395 498648 109305721
Abdominal discomfort 730.47 9.96 5042 779888 388816 109415553
Arthralgia 720.94 9.96 8576 776354 771056 109033313
Infusion related reaction 702.99 9.96 4873 780057 376289 109428080
Helicobacter infection 700.38 9.96 2851 782079 179026 109625343
Swelling 686.16 9.96 4553 780377 346488 109457881
Alopecia 649.59 9.96 4624 780306 360129 109444240
Psoriatic arthropathy 623.65 9.96 2909 782021 193852 109610517
Therapeutic product effect decreased 619.67 9.96 3392 781538 240924 109563445
Intentional overdose 571.76 9.96 121 784809 132380 109671989
Discomfort 559.32 9.96 3003 781927 211704 109592665
Rheumatoid factor positive 544.85 9.96 2111 782819 129529 109674840
Death 537.77 9.96 2843 782087 696026 109108343
Contraindicated product administered 531.55 9.96 3296 781634 244971 109559398
Pain 524.36 9.96 9599 775331 945356 108859013
Impaired healing 507.34 9.96 2744 782186 193973 109610396
Musculoskeletal stiffness 504.09 9.96 3558 781372 276264 109528105
Hepatic enzyme increased 484.50 9.96 3914 781016 316978 109487391
Febrile neutropenia 478.41 9.96 953 783977 315814 109488555
Acute kidney injury 464.45 9.96 2629 782301 632801 109171568
Folliculitis 455.10 9.96 2372 782558 165281 109639088
Nasopharyngitis 440.35 9.96 4506 780424 389855 109414514
Blister 411.04 9.96 2894 782036 224482 109579887
Irritable bowel syndrome 410.15 9.96 2271 782659 161944 109642425
Muscle injury 406.48 9.96 2027 782903 138780 109665589
C-reactive protein abnormal 403.08 9.96 1907 783023 127788 109676581
Drug intolerance 386.09 9.96 4498 780432 402014 109402355
Fibromyalgia 375.70 9.96 2285 782645 168624 109635745
Lower respiratory tract infection 373.16 9.96 2977 781953 240129 109564240
Rheumatic fever 371.23 9.96 1789 783141 120790 109683579
Sleep disorder due to general medical condition, insomnia type 362.20 9.96 1599 783331 104044 109700325
Exposure during pregnancy 352.05 9.96 2213 782717 165211 109639158
Depressed level of consciousness 340.52 9.96 186 784744 112092 109692277
Disease progression 336.82 9.96 772 784158 243262 109561107
Suicide attempt 336.51 9.96 156 784774 103238 109701131
Sinusitis 323.34 9.96 3374 781556 293314 109511055
Cardiac arrest 316.16 9.96 570 784360 196183 109608186
Peripheral swelling 314.63 9.96 4309 780621 399725 109404644
Ill-defined disorder 312.36 9.96 2045 782885 154808 109649561
Osteoarthritis 310.10 9.96 2290 782640 180333 109624036
Hypersensitivity 300.58 9.96 4274 780656 399724 109404645
Malignant neoplasm progression 300.43 9.96 484 784446 174083 109630286
Type 2 diabetes mellitus 291.07 9.96 2205 782725 175027 109629342
Swollen joint count increased 285.03 9.96 1264 783666 82397 109721972
Stomatitis 283.07 9.96 3049 781881 267193 109537176
Weight increased 282.25 9.96 4363 780567 415281 109389088
Rhabdomyolysis 266.85 9.96 276 784654 120125 109684244
Constipation 264.92 9.96 1473 783457 356313 109448056
Inflammation 264.25 9.96 2306 782624 190932 109613437
Overdose 263.24 9.96 818 784112 232976 109571393
Sedation 260.01 9.96 85 784845 69598 109734771
Neutropenia 256.25 9.96 1582 783348 373038 109431331
Treatment failure 253.42 9.96 3046 781884 274188 109530181
Lactic acidosis 251.92 9.96 175 784755 92636 109711733
Bradycardia 244.96 9.96 456 784474 155061 109649308
Multiple organ dysfunction syndrome 241.48 9.96 442 784488 151268 109653101
Contusion 239.30 9.96 2622 782308 230739 109573630
Hepatic function abnormal 236.30 9.96 173 784757 89122 109715247
Facet joint syndrome 232.98 9.96 1326 783604 95502 109708867
Cardiac failure 228.23 9.96 633 784297 186993 109617376
Hyponatraemia 228.09 9.96 786 784144 216867 109587502
Joint range of motion decreased 227.85 9.96 1564 783366 120268 109684101
Coma 225.04 9.96 304 784626 117565 109686804
Red blood cell sedimentation rate abnormal 220.17 9.96 517 784413 23992 109780377
Serotonin syndrome 219.22 9.96 73 784857 59080 109745289
Sickle cell anaemia with crisis 218.66 9.96 303 784627 9242 109795127
Respiratory failure 216.06 9.96 792 784138 214540 109589829
Drug reaction with eosinophilia and systemic symptoms 212.15 9.96 163 784767 81932 109722437
Blood cholesterol increased 211.93 9.96 2124 782806 182661 109621708
Hypotension 211.90 9.96 2538 782392 521311 109283058
Knee arthroplasty 210.54 9.96 967 783963 63981 109740388
Drug resistance 209.92 9.96 69 784861 56305 109748064
Renal failure 208.98 9.96 862 784068 225712 109578657
Grip strength decreased 207.61 9.96 1120 783810 79054 109725315
Electrocardiogram QT prolonged 207.03 9.96 282 784648 108678 109695691
Renal impairment 206.03 9.96 668 784262 187777 109616592
Myelosuppression 204.86 9.96 220 784710 94120 109710249
Somnolence 202.36 9.96 1258 783672 296191 109508178
Drug ineffective for unapproved indication 200.64 9.96 261 784669 102577 109701792
Arthritis 198.84 9.96 1940 782990 165646 109638723
Pregnancy 195.94 9.96 800 784130 50267 109754102
Product use issue 191.51 9.96 3193 781737 308502 109495867
Lip dry 190.22 9.96 1290 783640 98793 109705576
Hip arthroplasty 188.39 9.96 841 784089 54972 109749397
Mobility decreased 185.75 9.96 2535 782395 234887 109569482
Infection 184.68 9.96 3603 781327 358597 109445772
Blood pressure systolic abnormal 184.05 9.96 487 784443 24363 109780006
Cytokine release syndrome 183.71 9.96 138 784792 70168 109734201
Intentional product use issue 181.89 9.96 2617 782313 245289 109559080
Blood pressure fluctuation 180.87 9.96 1026 783904 73798 109730571
Respiratory arrest 180.54 9.96 94 784836 58205 109746164
Injury 176.76 9.96 1981 782949 175284 109629085
Angioedema 176.20 9.96 266 784664 98234 109706135
Hypoglycaemia 175.36 9.96 349 784581 115755 109688614
Blood pressure systolic increased 174.98 9.96 1098 783832 81893 109722476
Blood pressure diastolic abnormal 173.33 9.96 488 784442 25327 109779042
Musculoskeletal pain 172.03 9.96 2022 782908 181001 109623368
Agitation 171.45 9.96 339 784591 112712 109691657
Bursitis 169.10 9.96 1534 783396 128384 109675985
Live birth 166.12 9.96 950 783980 68534 109735835
Hyperhidrosis 165.05 9.96 725 784205 186573 109617796
Off label use 162.84 9.96 8852 776078 1491333 108313036
Sopor 162.57 9.96 31 784899 36515 109767854
Neoplasm progression 162.19 9.96 132 784798 64463 109739906
C-reactive protein increased 160.45 9.96 2302 782628 215617 109588752
Altered state of consciousness 159.94 9.96 106 784824 57520 109746849
Intentional product misuse 155.27 9.96 457 784473 132447 109671922
Red blood cell sedimentation rate increased 152.84 9.96 1016 783914 77286 109727083
Hepatic failure 150.69 9.96 159 784771 68580 109735789
Deep vein thrombosis postoperative 147.27 9.96 819 784111 58472 109745897
Sepsis 144.76 9.96 1554 783376 325792 109478577
Cardio-respiratory arrest 144.43 9.96 386 784544 115450 109688919
Abortion spontaneous 143.56 9.96 552 784378 33730 109770639
Obesity 142.26 9.96 1328 783602 112023 109692346
Cytomegalovirus infection 142.08 9.96 107 784823 54337 109750032
Gastrointestinal disorder 141.80 9.96 2460 782470 239492 109564877
Metabolic acidosis 140.41 9.96 312 784618 99432 109704937
Liver injury 140.12 9.96 1659 783271 148754 109655615
Wound infection 139.59 9.96 1166 783764 95299 109709070
Breast cancer stage III 139.31 9.96 1001 783929 78116 109726253
Hyperglycaemia 137.08 9.96 246 784684 84844 109719525
Sciatica 136.45 9.96 1122 783808 91277 109713092
Anaemia 135.67 9.96 2905 782025 544181 109260188
Tachycardia 133.97 9.96 999 783931 225646 109578723
Thrombocytopenia 132.76 9.96 1712 783218 347173 109457196
Peripheral venous disease 132.70 9.96 1037 783893 83080 109721289
Neuropathy peripheral 130.43 9.96 742 784188 178535 109625834
Hypoxia 130.11 9.96 476 784454 129039 109675330
Shock 129.04 9.96 114 784816 53474 109750895
Joint effusion 128.60 9.96 383 784547 20522 109783847
Drug dependence 127.10 9.96 101 784829 49919 109754450
Anaphylactic shock 123.71 9.96 110 784820 51436 109752933
Pain in extremity 123.64 9.96 4420 780510 482698 109321671
Intentional self-injury 122.50 9.96 56 784874 37373 109766996
Ventricular fibrillation 121.56 9.96 71 784859 41242 109763127
Autoimmune disorder 120.24 9.96 837 784093 64646 109739723
Syncope 119.57 9.96 893 784037 201643 109602726
Respiratory depression 119.44 9.96 39 784891 31962 109772407
Cognitive disorder 118.91 9.96 279 784651 87232 109717137
Poisoning 118.71 9.96 30 784900 29075 109775294
Hyperkalaemia 113.44 9.96 536 784394 135260 109669109
Seizure 113.31 9.96 1013 783917 220172 109584197
Product use in unapproved indication 113.06 9.96 2368 782562 445009 109359360
Palmar-plantar erythrodysaesthesia syndrome 111.79 9.96 77 784853 40948 109763421
Condition aggravated 111.39 9.96 6326 778604 728510 109075859
Bone erosion 110.18 9.96 633 784297 45738 109758631
Neurotoxicity 110.07 9.96 83 784847 42124 109762245
Fatigue 109.97 9.96 10036 774894 1205922 108598447
Road traffic accident 109.66 9.96 1206 783724 106192 109698177
Ventricular tachycardia 109.25 9.96 116 784814 49893 109754476
Foot deformity 108.87 9.96 652 784278 47828 109756541
Disability assessment scale score increased 107.63 9.96 142 784788 4128 109800241
Rash 107.35 9.96 6976 777954 813988 108990381
Joint stiffness 107.18 9.96 831 784099 66412 109737957
Drug use disorder 107.07 9.96 5 784925 18069 109786300
Ascites 107.04 9.96 321 784609 92487 109711882
Disseminated intravascular coagulation 106.63 9.96 82 784848 41204 109763165
General physical health deterioration 104.93 9.96 3847 781083 421448 109382921
Gait inability 104.50 9.96 1451 783479 134925 109669444
Encephalopathy 104.17 9.96 266 784664 80789 109723580
Cardiogenic shock 102.39 9.96 155 784775 57183 109747186
Sedation complication 101.88 9.96 11 784919 19844 109784525
Blood pressure diastolic decreased 101.64 9.96 514 784416 35371 109768998
Neutrophil count decreased 100.64 9.96 478 784452 120463 109683906
Nausea 100.42 9.96 7484 777446 1228206 108576163
Tremor 100.19 9.96 934 783996 201298 109603071
No adverse event 99.06 9.96 237 784693 73602 109730767
Hypoaesthesia 98.76 9.96 2925 782005 311298 109493071
Suicidal ideation 96.49 9.96 342 784588 93595 109710774
Psoriasis 96.39 9.96 1462 783468 138531 109665838
Adverse event 94.74 9.96 1185 783745 107624 109696745
Injection site reaction 94.54 9.96 1008 783922 88062 109716307
Suspected suicide 94.14 9.96 3 784927 15196 109789173
Cerebral haemorrhage 94.10 9.96 200 784730 64768 109739601
Pulmonary fibrosis 93.92 9.96 1123 783807 100919 109703450
Heart rate decreased 93.74 9.96 949 783981 81807 109722562
Lower limb fracture 93.64 9.96 881 784049 74467 109729902
Blood creatine phosphokinase increased 93.00 9.96 241 784689 72836 109731533
Myalgia 92.60 9.96 1070 783860 221311 109583058
Hypokalaemia 92.38 9.96 838 784092 181610 109622759
Acute hepatic failure 92.20 9.96 74 784856 36394 109767975
Mydriasis 92.00 9.96 22 784908 22135 109782234
Enthesopathy 91.86 9.96 244 784686 12234 109792135
Hepatocellular injury 91.30 9.96 136 784794 50506 109753863
Neuroleptic malignant syndrome 90.08 9.96 66 784864 33993 109770376
Blood creatinine increased 90.02 9.96 846 784084 182043 109622326
Dehydration 89.91 9.96 1418 783512 278093 109526276
Restlessness 89.41 9.96 164 784766 56095 109748274
Hypercholesterolaemia 89.08 9.96 1012 783918 89825 109714544
Leukopenia 87.82 9.96 656 784274 148135 109656234
Adjustment disorder with depressed mood 87.81 9.96 573 784357 43310 109761059
Osteoporosis 87.75 9.96 976 783954 86176 109718193
Dry mouth 87.07 9.96 1944 782986 198004 109606365
Polyarthritis 86.61 9.96 314 784616 18649 109785720
Dislocation of vertebra 85.73 9.96 568 784362 43153 109761216
Chest discomfort 85.64 9.96 804 784126 173044 109631325
Orthostatic hypotension 85.45 9.96 217 784713 66032 109738337
Disturbance in attention 84.75 9.96 197 784733 61798 109742571
Dry skin 84.67 9.96 434 784496 107219 109697150
Aspergillus infection 82.79 9.96 39 784891 25577 109778792
Cardiac failure congestive 82.48 9.96 680 784250 150320 109654049
Rheumatoid nodule 81.88 9.96 323 784607 19973 109784396
Joint destruction 81.59 9.96 215 784715 10728 109793641
Vision blurred 81.41 9.96 558 784372 128464 109675905
Drug withdrawal syndrome 81.21 9.96 90 784840 37964 109766405
Appendicolith 81.15 9.96 5 784925 14250 109790119
Hallucination 80.87 9.96 407 784523 101025 109703344
Wrong technique in product usage process 80.68 9.96 332 784598 87016 109717353
Atrial fibrillation 80.39 9.96 1146 783784 228496 109575873
Juvenile idiopathic arthritis 80.08 9.96 149 784781 5858 109798511
Myoclonus 79.69 9.96 70 784860 32928 109771441
Platelet count decreased 79.27 9.96 1154 783776 229289 109575080
Post transplant lymphoproliferative disorder 79.23 9.96 9 784921 15604 109788765
C-reactive protein 78.02 9.96 423 784507 29908 109774461
Night sweats 77.63 9.96 1360 783570 132623 109671746
Myocardial infarction 76.97 9.96 932 783998 191151 109613218
Cholestasis 76.69 9.96 220 784710 64298 109740071
Venoocclusive liver disease 76.58 9.96 9 784921 15198 109789171
Cerebral infarction 76.40 9.96 158 784772 51680 109752689
Blood glucose increased 75.44 9.96 590 784340 131906 109672463
Skin exfoliation 74.95 9.96 343 784587 87308 109717061
Aggression 74.79 9.96 196 784734 59014 109745355
Proteinuria 74.57 9.96 105 784825 39913 109764456
Therapy partial responder 74.42 9.96 92 784838 36969 109767400
Withdrawal syndrome 74.06 9.96 68 784862 31312 109773057
Accidental exposure to product 74.06 9.96 152 784778 49856 109754513
Thrombotic microangiopathy 73.88 9.96 59 784871 29090 109775279
Sleep disorder 73.63 9.96 1889 783041 196755 109607614
Psychotic disorder 72.78 9.96 158 784772 50779 109753590
Dysphagia 72.42 9.96 718 784212 152882 109651487
Disorientation 72.11 9.96 258 784672 70413 109733956
Ejection fraction decreased 71.56 9.96 112 784818 40768 109763601
Temperature regulation disorder 71.53 9.96 5 784925 12821 109791548
Forced expiratory volume decreased 71.05 9.96 6 784924 13170 109791199
Akathisia 71.04 9.96 17 784913 17096 109787273
Pulmonary alveolar haemorrhage 71.02 9.96 27 784903 20123 109784246
Hypothermia 70.83 9.96 50 784880 26252 109778117
Torsade de pointes 70.63 9.96 36 784894 22564 109781805
BK virus infection 70.58 9.96 6 784924 13100 109791269
Pathogen resistance 70.58 9.96 19 784911 17653 109786716
Posterior reversible encephalopathy syndrome 70.18 9.96 82 784848 33779 109770590
Gamma-glutamyltransferase increased 70.02 9.96 213 784717 61096 109743273
Respiratory distress 69.90 9.96 252 784678 68622 109735747
Anaphylactic reaction 69.33 9.96 500 784430 113800 109690569
Onychomadesis 69.30 9.96 558 784372 45105 109759264
Onychomycosis 69.27 9.96 490 784440 38041 109766328
Cytomegalovirus infection reactivation 69.03 9.96 22 784908 18311 109786058
Drug level increased 69.02 9.96 147 784783 47572 109756797
Bronchopulmonary aspergillosis 68.97 9.96 66 784864 29797 109774572
Exposure to toxic agent 68.94 9.96 6 784924 12852 109791517
Tenosynovitis 68.84 9.96 263 784667 16020 109788349
Miosis 68.72 9.96 35 784895 21948 109782421
Blood pressure diastolic increased 68.51 9.96 290 784640 18517 109785852
Diabetic ketoacidosis 68.27 9.96 121 784809 41937 109762432
Dysarthria 67.94 9.96 336 784594 83785 109720584
White blood cell count decreased 67.76 9.96 1182 783748 228208 109576161
Extrapyramidal disorder 67.60 9.96 63 784867 28804 109775565
Haemoptysis 67.29 9.96 269 784661 71085 109733284
Body temperature decreased 66.57 9.96 470 784460 36465 109767904
Loss of consciousness 66.13 9.96 987 783943 195319 109609050
Disease recurrence 66.02 9.96 216 784714 60568 109743801
Laryngitis 65.86 9.96 521 784409 41890 109762479
Caesarean section 65.85 9.96 232 784698 13585 109790784
Immune reconstitution inflammatory syndrome 65.65 9.96 17 784913 16209 109788160
Blepharospasm 65.02 9.96 635 784295 54216 109750153
Unresponsive to stimuli 64.34 9.96 234 784696 63556 109740813
Substance abuse 63.71 9.96 7 784923 12456 109791913
Creatinine renal clearance decreased 63.46 9.96 38 784892 21777 109782592
Asphyxia 63.35 9.96 12 784918 14203 109790166
Lung disorder 63.20 9.96 1700 783230 178347 109626022
Loss of personal independence in daily activities 62.93 9.96 1451 783479 148569 109655800
Acute respiratory distress syndrome 62.79 9.96 182 784748 53016 109751353
Brain oedema 62.65 9.96 77 784853 31021 109773348
Joint laxity 62.62 9.96 83 784847 2424 109801945
Haematotoxicity 62.35 9.96 36 784894 21046 109783323
Balance disorder 62.25 9.96 528 784402 116032 109688337
Abnormal behaviour 61.86 9.96 114 784816 38925 109765444
X-ray abnormal 61.82 9.96 473 784457 37644 109766725
Acute graft versus host disease 61.57 9.96 9 784921 12872 109791497
Oedema 60.70 9.96 1935 782995 208041 109596328
Dyspnoea 60.65 9.96 6905 778025 1099967 108704402
Wheezing 60.06 9.96 2297 782633 252933 109551436
Ear infection 59.76 9.96 695 784235 62037 109742332
Status epilepticus 59.66 9.96 82 784848 31489 109772880
Lupus-like syndrome 59.49 9.96 494 784436 40298 109764071
Exostosis 59.45 9.96 542 784388 45414 109758955
Hemiplegia 59.15 9.96 45 784885 22737 109781632
Localised infection 58.92 9.96 514 784416 42534 109761835
Melaena 58.82 9.96 269 784661 68488 109735881
Irritability 58.32 9.96 161 784769 47648 109756721
Arrhythmia 57.87 9.96 275 784655 69300 109735069
Finger deformity 57.84 9.96 418 784512 32674 109771695
Dystonia 57.33 9.96 59 784871 25746 109778623
Anti-cyclic citrullinated peptide antibody 57.27 9.96 287 784643 19677 109784692
Interstitial lung disease 56.98 9.96 673 784257 138661 109665708
Gestational diabetes 56.96 9.96 147 784783 7242 109797127
Retinitis 56.89 9.96 409 784521 31918 109772451
Mucormycosis 56.87 9.96 5 784925 10623 109793746
Clostridium difficile colitis 56.77 9.96 143 784787 43635 109760734
Pulmonary oedema 56.47 9.96 450 784480 100209 109704160
Aphasia 55.89 9.96 222 784708 58775 109745594
Rebound effect 55.33 9.96 18 784912 14788 109789581
Toxic epidermal necrolysis 55.31 9.96 211 784719 56516 109747853
Personality disorder 54.79 9.96 12 784918 12825 109791544
Exposure via skin contact 54.69 9.96 13 784917 13134 109791235
Second primary malignancy 54.67 9.96 30 784900 18038 109786331
Basal cell carcinoma 54.60 9.96 526 784404 44744 109759625
Coagulopathy 54.33 9.96 132 784798 40779 109763590
Tumour lysis syndrome 54.28 9.96 84 784846 30717 109773652
Tachypnoea 53.99 9.96 125 784805 39270 109765099
Blood bilirubin increased 53.86 9.96 317 784613 75655 109728714
Neurologic neglect syndrome 53.72 9.96 3 784927 9295 109795074
Lupus vulgaris 53.58 9.96 418 784512 33465 109770904
Inappropriate antidiuretic hormone secretion 53.50 9.96 99 784831 33752 109770617
Pancreatitis acute 53.25 9.96 233 784697 60041 109744328
Speech disorder 53.19 9.96 240 784690 61329 109743040
Eosinophilia 53.01 9.96 221 784709 57715 109746654
Graft versus host disease 52.99 9.96 34 784896 18772 109785597
Hepatic cirrhosis 52.79 9.96 722 784208 66904 109737465
Psychomotor hyperactivity 52.71 9.96 40 784890 20237 109784132
Transplant rejection 52.54 9.96 58 784872 24509 109779860
Bronchospasm 51.84 9.96 84 784846 30155 109774214
Graft versus host disease in gastrointestinal tract 51.49 9.96 3 784927 8965 109795404
Nail disorder 51.30 9.96 633 784297 57302 109747067
Unintentional medical device removal 51.19 9.96 3 784927 8920 109795449
Dyskinesia 51.05 9.96 190 784740 51256 109753113
Haemophagocytic lymphohistiocytosis 51.04 9.96 91 784839 31468 109772901
Osteonecrosis of jaw 50.53 9.96 173 784757 47844 109756525
Device difficult to use 50.31 9.96 36 784894 18769 109785600
Drug dose omission by device 50.25 9.96 20 784910 14496 109789873
Diarrhoea 50.19 9.96 7208 777722 1132297 108672072
COVID-19 50.19 9.96 1339 783591 243721 109560648
Stevens-Johnson syndrome 50.02 9.96 168 784762 46733 109757636
Septic shock 50.01 9.96 801 784129 156727 109647642
Joint dislocation 49.83 9.96 414 784516 33776 109770593
Prescribed overdose 49.65 9.96 886 784044 86695 109717674
Adenovirus infection 49.60 9.96 9 784921 10985 109793384
Chronic kidney disease 49.09 9.96 328 784602 75963 109728406
Cytomegalovirus viraemia 48.86 9.96 33 784897 17731 109786638
Maternal exposure timing unspecified 48.72 9.96 285 784645 20728 109783641
Dermatitis atopic 48.60 9.96 66 784864 25475 109778894
Cytopenia 48.56 9.96 87 784843 30029 109774340
Hypomagnesaemia 48.25 9.96 242 784688 60128 109744241
Hypophosphataemia 48.17 9.96 102 784828 33080 109771289
Pulmonary embolism 47.36 9.96 1159 783771 213315 109591054
Blood calcium decreased 47.33 9.96 116 784814 35729 109768640
Acute respiratory failure 47.22 9.96 326 784604 74934 109729435
Mental status changes 47.13 9.96 331 784599 75791 109728578
Acute chest syndrome 47.04 9.96 66 784864 2037 109802332
Red blood cell sedimentation rate 46.84 9.96 110 784820 5104 109799265
Face oedema 46.84 9.96 105 784825 33364 109771005
Angina pectoris 46.83 9.96 255 784675 62040 109742329
Mania 46.82 9.96 47 784883 20749 109783620
Rash erythematous 46.76 9.96 364 784566 81468 109722901
Lymphocyte count decreased 46.59 9.96 228 784702 57015 109747354
Polyomavirus-associated nephropathy 46.31 9.96 3 784927 8198 109796171
Palpitations 46.17 9.96 823 784107 158389 109645980
Blood alkaline phosphatase increased 46.13 9.96 304 784626 70631 109733738
Hypothyroidism 46.12 9.96 315 784615 72584 109731785
Acute graft versus host disease in skin 45.92 9.96 10 784920 10730 109793639
Muscle rigidity 45.83 9.96 62 784868 23969 109780400
Hallucination, visual 45.65 9.96 137 784793 39468 109764901
Haemorrhage intracranial 45.54 9.96 85 784845 28884 109775485
Carotid artery thrombosis 45.45 9.96 7 784923 9631 109794738
Tendonitis 44.75 9.96 328 784602 25755 109778614
Pleural effusion 44.70 9.96 941 783989 176768 109627601
Drug tolerance decreased 44.24 9.96 341 784589 27199 109777170
Wheelchair user 43.88 9.96 139 784791 7703 109796666
Back injury 43.76 9.96 522 784408 46877 109757492
Maternal exposure before pregnancy 43.64 9.96 132 784798 7133 109797236
Muscle twitching 43.47 9.96 92 784838 29843 109774526
Metastases to bone 43.43 9.96 99 784831 31273 109773096
Metastases to central nervous system 43.38 9.96 59 784871 22758 109781611
Acute generalised exanthematous pustulosis 43.26 9.96 54 784876 21610 109782759
Gastrointestinal haemorrhage 43.25 9.96 871 784059 164647 109639722
Hyperbilirubinaemia 43.10 9.96 96 784834 30575 109773794
Hemiparesis 43 9.96 163 784767 43740 109760629
Injection site erythema 43.00 9.96 922 784008 93254 109711115
Rash maculo-papular 42.95 9.96 329 784601 73893 109730476
Pneumonia aspiration 42.91 9.96 369 784561 80864 109723505
Obstructive airways disorder 42.87 9.96 175 784755 45974 109758395
Prescribed underdose 42.68 9.96 675 784255 64499 109739870
Metastases to liver 42.54 9.96 120 784810 35266 109769103
Bradyphrenia 42.54 9.96 15 784915 11713 109792656
Coordination abnormal 42.39 9.96 71 784859 25157 109779212
Paradoxical drug reaction 42.26 9.96 9 784921 9808 109794561
Tongue disorder 42.05 9.96 207 784723 14091 109790278
Agranulocytosis 42.04 9.96 261 784669 61499 109742870
Cerebrovascular accident 41.86 9.96 973 783957 180311 109624058
Erythema multiforme 41.70 9.96 53 784877 21044 109783325
Emotional distress 41.70 9.96 170 784760 44677 109759692
Urinary retention 41.69 9.96 306 784624 69377 109734992
Blood pressure decreased 41.44 9.96 571 784359 114520 109689849
Alanine aminotransferase abnormal 41.32 9.96 153 784777 9181 109795188
Flushing 41.25 9.96 510 784420 104226 109700143
Leukocytosis 41.20 9.96 219 784711 53609 109750760
Parkinsonism 40.56 9.96 59 784871 22128 109782241
Bacteraemia 40.48 9.96 159 784771 42231 109762138
Hyperthermia 40.45 9.96 55 784875 21217 109783152
Pyrexia 40.42 9.96 5674 779256 892591 108911778
Blood phosphorus increased 40.26 9.96 34 784896 16306 109788063
Multiple-drug resistance 40.01 9.96 22 784908 13213 109791156
Nodule 39.77 9.96 380 784550 32251 109772118
Toxic skin eruption 39.59 9.96 85 784845 27430 109776939
Cardiotoxicity 39.34 9.96 37 784893 16844 109787525
Cardiomyopathy 39.34 9.96 115 784815 33410 109770959
Ischaemic stroke 39.26 9.96 155 784775 41108 109763261
Acidosis 39.18 9.96 62 784868 22469 109781900
Injection site pruritus 39.09 9.96 545 784385 50713 109753656
Coronary artery disease 39.06 9.96 323 784607 71367 109733002
Vomiting 39.06 9.96 5769 779161 904906 108899463
Aspartate aminotransferase increased 39.03 9.96 851 784079 159085 109645284
Neck deformity 38.97 9.96 57 784873 1829 109802540
Haemorrhage 38.89 9.96 528 784402 106164 109698205
Procedural pain 38.89 9.96 126 784804 35439 109768930
Disability 38.86 9.96 356 784574 29867 109774502
Fracture 38.75 9.96 305 784625 24483 109779886
Sinus tachycardia 38.70 9.96 173 784757 44320 109760049
Premature labour 38.66 9.96 148 784782 9024 109795345
Femur fracture 38.57 9.96 484 784446 43985 109760384
Appendicitis 38.46 9.96 91 784839 28373 109775996
Generalised tonic-clonic seizure 38.31 9.96 229 784701 54451 109749918
Glycosylated haemoglobin increased 38.29 9.96 68 784862 23551 109780818
Chronic graft versus host disease 38.09 9.96 10 784920 9447 109794922
Colitis 37.80 9.96 505 784425 101818 109702551
Pseudomonas infection 37.67 9.96 89 784841 27764 109776605
Myocarditis 37.57 9.96 100 784830 29955 109774414
Premature rupture of membranes 37.56 9.96 94 784836 4543 109799826
Electrocardiogram QRS complex prolonged 37.43 9.96 23 784907 12998 109791371
Hepatotoxicity 37.17 9.96 280 784650 63120 109741249
Multiple sclerosis relapse 37.02 9.96 207 784723 50033 109754336
Shock haemorrhagic 36.90 9.96 87 784843 27160 109777209
Synovial cyst 36.90 9.96 170 784760 11260 109793109
Tenderness 36.47 9.96 344 784586 29093 109775276
Ankylosing spondylitis 36.36 9.96 212 784718 15400 109788969
Tardive dyskinesia 36.32 9.96 26 784904 13553 109790816
Epstein-Barr virus infection 36.08 9.96 48 784882 18690 109785679
Latent tuberculosis 35.83 9.96 84 784846 3893 109800476
Diabetes mellitus 35.80 9.96 493 784437 98888 109705481
Fear 35.63 9.96 69 784861 23124 109781245
Skin haemorrhage 35.47 9.96 77 784853 24750 109779619
Motor dysfunction 35.45 9.96 75 784855 24331 109780038
Diabetes insipidus 35.40 9.96 3 784927 6567 109797802
Migraine 35.32 9.96 1523 783407 170129 109634240
Schizophrenia 35.24 9.96 63 784867 21763 109782606
Conjunctivitis allergic 35.16 9.96 4 784926 6927 109797442
Acute myeloid leukaemia 35.09 9.96 145 784785 37965 109766404
Proctitis 35.07 9.96 41 784889 16886 109787483
Depressed mood 34.97 9.96 270 784660 60539 109743830
Haematoma 34.88 9.96 257 784673 58219 109746150
Hyperuricaemia 34.88 9.96 31 784899 14500 109789869
Klebsiella infection 34.85 9.96 55 784875 19954 109784415
Eating disorder 34.67 9.96 108 784822 30750 109773619
Graft versus host disease in skin 34.66 9.96 8 784922 8246 109796123
Blood parathyroid hormone decreased 34.65 9.96 184 784746 12905 109791464
Subdural haematoma 34.64 9.96 137 784793 36317 109768052
Hepatic encephalopathy 34.58 9.96 95 784835 28161 109776208
Smear cervix abnormal 34.58 9.96 66 784864 2646 109801723
Haemodynamic instability 34.38 9.96 69 784861 22819 109781550
Tuberculosis 34.29 9.96 230 784700 17544 109786825
Fluid retention 34.27 9.96 467 784463 93840 109710529
Potentiating drug interaction 34.27 9.96 20 784910 11623 109792746
Ileus 34.21 9.96 108 784822 30621 109773748
Device leakage 34.19 9.96 38 784892 16010 109788359
Cardiac failure acute 34.14 9.96 75 784855 24003 109780366
Acute myocardial infarction 34.11 9.96 405 784525 83372 109720997
Spinal stenosis 34.05 9.96 242 784688 18814 109785555
Nocardiosis 34.05 9.96 6 784924 7480 109796889
Seronegative arthritis 34.04 9.96 184 784746 12993 109791376
Infective pulmonary exacerbation of cystic fibrosis 33.70 9.96 33 784897 14738 109789631
Anuria 33.55 9.96 77 784853 24264 109780105
Feeling abnormal 33.52 9.96 1001 783929 179710 109624659
Glomerular filtration rate decreased 33.49 9.96 100 784830 28856 109775513
Cystitis haemorrhagic 33.15 9.96 23 784907 12186 109792183
Stress cardiomyopathy 33.05 9.96 38 784892 15768 109788601
Scleritis 33.05 9.96 99 784831 5321 109799048
Arthritis infective 32.85 9.96 154 784776 10275 109794094
Vaginal flatulence 32.81 9.96 23 784907 12121 109792248
Device expulsion 32.70 9.96 111 784819 30780 109773589
Bone pain 32.59 9.96 300 784630 64833 109739536
Respiratory acidosis 32.58 9.96 30 784900 13796 109790573
Product prescribing error 32.37 9.96 222 784708 51109 109753260
Neck mass 32.23 9.96 91 784839 4730 109799639
Granuloma skin 32.22 9.96 162 784768 11121 109793248
Enterocolitis 32.14 9.96 53 784877 18896 109785473
Hyperammonaemia 32.12 9.96 30 784900 13702 109790667
Candida infection 32.11 9.96 204 784726 47805 109756564
Hepatitis B reactivation 31.93 9.96 7 784923 7477 109796892
Sinus bradycardia 31.86 9.96 105 784825 29378 109774991
Food allergy 31.83 9.96 58 784872 19890 109784479
Oliguria 31.82 9.96 52 784878 18605 109785764
Dissociation 31.78 9.96 15 784915 9827 109794542
Jaundice cholestatic 31.78 9.96 34 784896 14574 109789795
Dust allergy 31.64 9.96 3 784927 5998 109798371
Antinuclear antibody positive 31.57 9.96 139 784791 9029 109795340
Liver disorder 31.52 9.96 1272 783658 140971 109663398
Immune effector cell-associated neurotoxicity syndrome 31.50 9.96 35 784895 14747 109789622
Limb deformity 31.47 9.96 77 784853 3669 109800700
Rhinitis allergic 31.46 9.96 49 784881 17873 109786496
Pneumothorax 31.41 9.96 136 784794 35149 109769220
Jaundice 31.32 9.96 269 784661 58967 109745402
Mental disorder 31.28 9.96 155 784775 38636 109765733
End stage renal disease 31.18 9.96 66 784864 21407 109782962
Multiple fractures 31.14 9.96 136 784794 8804 109795565
Adjustment disorder 31.13 9.96 19 784911 10776 109793593
Blood lactic acid increased 31.01 9.96 40 784890 15781 109788588
Nephropathy toxic 30.99 9.96 96 784834 27382 109776987
Colorectal cancer 30.83 9.96 13 784917 9101 109795268
Pemphigoid 30.82 9.96 58 784872 19649 109784720
Sexual dysfunction 30.79 9.96 11 784919 8519 109795850
Generalised oedema 30.72 9.96 113 784817 30591 109773778
Polyneuropathy 30.61 9.96 120 784810 31892 109772477
Mouth ulceration 30.56 9.96 496 784434 47642 109756727
Labelled drug-drug interaction medication error 30.54 9.96 106 784824 29196 109775173
Paraesthesia oral 30.45 9.96 129 784801 33542 109770827
Pre-eclampsia 30.44 9.96 132 784798 8518 109795851
Pulmonary vasculitis 30.41 9.96 5 784925 6555 109797814
Cardiac failure chronic 30.21 9.96 32 784898 13779 109790590
Gastroenteritis viral 30.20 9.96 347 784583 30879 109773490
Metastases to lung 30.16 9.96 75 784855 22988 109781381
Hypernatraemia 30.14 9.96 50 784880 17783 109786586
Euglycaemic diabetic ketoacidosis 30.12 9.96 23 784907 11600 109792769
Rotator cuff repair 29.95 9.96 56 784874 2210 109802159
Drug tolerance 29.86 9.96 211 784719 16374 109787995
Myasthenia gravis 29.68 9.96 68 784862 21443 109782926
Liver function test increased 29.62 9.96 831 784099 87717 109716652
Chills 29.59 9.96 1080 783850 189500 109614869
Bacterial infection 29.58 9.96 198 784732 45838 109758531
Acute coronary syndrome 29.57 9.96 76 784854 23036 109781333
Febrile bone marrow aplasia 29.49 9.96 49 784881 17416 109786953
Cyanosis 29.40 9.96 110 784820 29631 109774738
Neck pain 29.38 9.96 1110 783820 122020 109682349
Skin ulcer 29.34 9.96 624 784306 63021 109741348
Pulmonary arterial hypertension 29.32 9.96 125 784805 32443 109771926
Hallucination, auditory 29.22 9.96 93 784837 26304 109778065
Device use error 29.12 9.96 14 784916 9075 109795294
Pneumatosis intestinalis 29.12 9.96 12 784918 8517 109795852
Hyperlipidaemia 29.05 9.96 143 784787 35705 109768664
Malignant mediastinal neoplasm 28.99 9.96 42 784888 1336 109803033
Delusion 28.97 9.96 80 784850 23675 109780694
Lethargy 28.97 9.96 478 784452 93098 109711271
Blood urea increased 28.87 9.96 250 784680 54707 109749662
Synovial disorder 28.73 9.96 65 784865 2942 109801427
Hepatitis acute 28.68 9.96 56 784874 18710 109785659
Lip swelling 28.65 9.96 226 784704 50441 109753928
Diplopia 28.54 9.96 177 784753 41717 109762652
Device related infection 28.49 9.96 164 784766 39355 109765014
Radiculopathy 28.44 9.96 59 784871 19277 109785092
Pulseless electrical activity 28.30 9.96 47 784883 16710 109787659
Dermatitis acneiform 28.23 9.96 29 784901 12666 109791703
Atrial tachycardia 28.12 9.96 15 784915 9163 109795206
Hypoalbuminaemia 28.10 9.96 108 784822 28866 109775503
Hypomania 28.03 9.96 19 784911 10191 109794178
Pruritus genital 28.03 9.96 6 784924 6516 109797853
Anxiety 27.98 9.96 2089 782841 342989 109461380
Vasoplegia syndrome 27.94 9.96 3 784927 5436 109798933
Pulmonary haemorrhage 27.94 9.96 46 784884 16410 109787959
Panniculitis 27.91 9.96 198 784732 15384 109788985
Mite allergy 27.86 9.96 4 784926 5799 109798570
Cytomegalovirus chorioretinitis 27.84 9.96 8 784922 7120 109797249
Multiple drug therapy 27.81 9.96 11 784919 8003 109796366
Lung opacity 27.80 9.96 25 784905 11627 109792742
Hyperlactacidaemia 27.74 9.96 12 784918 8274 109796095
Therapy non-responder 27.68 9.96 1374 783556 155933 109648436
Rheumatoid lung 27.57 9.96 80 784850 4224 109800145
Transaminases increased 27.55 9.96 302 784628 63088 109741281
Erythema 27.50 9.96 1741 783189 289706 109514663
Premature delivery 27.25 9.96 335 784595 30297 109774072
Endophthalmitis 27.18 9.96 12 784918 8175 109796194
Troponin increased 26.95 9.96 114 784816 29652 109774717
Myopathy 26.90 9.96 89 784841 24871 109779498
Bronchitis 26.89 9.96 1368 783562 155664 109648705
Pancytopenia 26.86 9.96 1779 783151 207834 109596535
Paranoia 26.80 9.96 76 784854 22298 109782071
Synovial fluid analysis 26.79 9.96 59 784871 2622 109801747
Sleep terror 26.60 9.96 7 784923 6603 109797766
Ankle arthroplasty 26.47 9.96 57 784873 2494 109801875
Female genital tract fistula 26.38 9.96 48 784882 16471 109787898
Sensory loss 26.36 9.96 72 784858 21385 109782984
Blood pressure increased 26.35 9.96 2153 782777 256220 109548149
Hepatitis cholestatic 26.34 9.96 53 784877 17513 109786856
Toxic encephalopathy 26.33 9.96 42 784888 15172 109789197
Hepatitis fulminant 26.21 9.96 14 784916 8546 109795823
Subarachnoid haemorrhage 26.13 9.96 115 784815 29587 109774782
Paralysis 26.12 9.96 44 784886 15556 109788813
Skin toxicity 26.11 9.96 27 784903 11756 109792613
Chronic sinusitis 25.97 9.96 91 784839 24993 109779376
Bone disorder 25.93 9.96 247 784683 20945 109783424
Circulatory collapse 25.62 9.96 189 784741 42804 109761565
Pulmonary congestion 25.40 9.96 123 784807 30843 109773526
Pneumonia bacterial 25.40 9.96 98 784832 26163 109778206
Alanine aminotransferase increased 25.35 9.96 1056 783874 182717 109621652
Peripheral sensory neuropathy 25.30 9.96 50 784880 16630 109787739
Eye pruritus 25.28 9.96 133 784797 32642 109771727
Hypocalcaemia 25.10 9.96 320 784610 65046 109739323
Tenosynovitis stenosans 25.06 9.96 69 784861 3534 109800835
Adverse drug reaction 25.04 9.96 951 783979 104608 109699761
Bladder cancer 25.00 9.96 68 784862 20224 109784145
Hyperpyrexia 25.00 9.96 13 784917 8056 109796313
Myocardial ischaemia 24.90 9.96 101 784829 26583 109777786
Affect lability 24.85 9.96 60 784870 18577 109785792
Product administered to patient of inappropriate age 24.82 9.96 13 784917 8023 109796346
Virologic failure 24.77 9.96 3 784927 4949 109799420
Drug effective for unapproved indication 24.62 9.96 39 784891 14128 109790241
Diabetes mellitus inadequate control 24.57 9.96 118 784812 29657 109774712
Epistaxis 24.46 9.96 721 784209 129651 109674718
Cleft lip and palate 24.36 9.96 28 784902 704 109803665
Normal newborn 24.26 9.96 250 784680 21646 109782723
Progressive multifocal leukoencephalopathy 24.22 9.96 93 784837 24863 109779506
Hypogammaglobulinaemia 24.19 9.96 68 784862 20008 109784361
Cross sensitivity reaction 24.18 9.96 5 784925 5562 109798807
Immune-mediated enterocolitis 24.12 9.96 22 784908 10163 109794206
International normalised ratio increased 24.06 9.96 452 784478 86320 109718049
Immune-mediated myositis 24.05 9.96 7 784923 6179 109798190
Product preparation error 24.02 9.96 25 784905 10854 109793515
Gangrene 23.92 9.96 50 784880 16291 109788078
Joint injury 23.88 9.96 408 784522 39586 109764783
Foot fracture 23.87 9.96 282 784648 25264 109779105
Loose body in joint 23.85 9.96 39 784891 1381 109802988
Lymphopenia 23.74 9.96 177 784753 39993 109764376
Ventricular arrhythmia 23.64 9.96 22 784908 10065 109794304
Blood lactate dehydrogenase increased 23.59 9.96 201 784729 44133 109760236
Affective disorder 23.53 9.96 27 784903 11214 109793155
Walking aid user 23.52 9.96 277 784653 24798 109779571
Atrioventricular block complete 23.48 9.96 69 784861 20013 109784356
Visual acuity reduced 23.47 9.96 133 784797 32040 109772329
Skin papilloma 23.33 9.96 104 784826 6792 109797577
Product prescribing issue 23.31 9.96 34 784896 12738 109791631
Product label confusion 23.30 9.96 255 784675 22422 109781947
Thrombosis 23.22 9.96 590 784340 108072 109696297
Hypercapnia 23.15 9.96 27 784903 11132 109793237
Right ventricular failure 23.13 9.96 100 784830 25854 109778515
Palmoplantar keratoderma 23.06 9.96 5 784925 5382 109798987
Nasal oedema 23.03 9.96 103 784827 6736 109797633
Polyuria 22.95 9.96 58 784872 17680 109786689
Hydrops foetalis 22.89 9.96 28 784902 753 109803616
Accidental death 22.81 9.96 4 784926 5005 109799364
Macular degeneration 22.81 9.96 78 784852 21581 109782788
Amyloid arthropathy 22.81 9.96 42 784888 1638 109802731
Kidney transplant rejection 22.78 9.96 31 784899 11956 109792413
Strongyloidiasis 22.67 9.96 4 784926 4982 109799387
Hepatocellular carcinoma 22.62 9.96 22 784908 9858 109794511
Poor venous access 22.61 9.96 270 784660 24252 109780117
Nail operation 22.56 9.96 42 784888 1652 109802717
Postoperative wound infection 22.56 9.96 190 784740 15563 109788806
Bradykinesia 22.49 9.96 26 784904 10762 109793607
Haematemesis 22.46 9.96 290 784640 58818 109745551
Presyncope 22.42 9.96 230 784700 48657 109755712
Nasal polyps 22.32 9.96 37 784893 13163 109791206
Hypoxic-ischaemic encephalopathy 22.30 9.96 18 784912 8829 109795540
Respiration abnormal 22.28 9.96 22 784908 9787 109794582
Rales 22.24 9.96 95 784835 24644 109779725
Renal tubular necrosis 22.22 9.96 126 784804 30349 109774020
Exposure via ingestion 22.13 9.96 4 784926 4896 109799473
Blindness 22.07 9.96 159 784771 36200 109768169
Spondylitis 22.04 9.96 147 784783 11191 109793178
Pericardial effusion 22.01 9.96 280 784650 56937 109747432
Ultrasound antenatal screen 21.82 9.96 26 784904 680 109803689
COVID-19 pneumonia 21.79 9.96 164 784766 36979 109767390
Human antichimeric antibody positive 21.73 9.96 42 784888 1700 109802669
Dyspnoea exertional 21.70 9.96 567 784363 103493 109700876
Acute pulmonary oedema 21.66 9.96 56 784874 16940 109787429
Venoocclusive disease 21.57 9.96 9 784921 6341 109798028
Sleep disorder due to a general medical condition 21.57 9.96 251 784679 51861 109752508
Acute myeloid leukaemia recurrent 21.54 9.96 5 784925 5134 109799235
Product administration error 21.51 9.96 165 784765 37052 109767317
Fracture delayed union 21.50 9.96 48 784882 2153 109802216
Ulcer haemorrhage 21.46 9.96 250 784680 22321 109782048
Mucocutaneous ulceration 21.46 9.96 27 784903 748 109803621
Gastric haemorrhage 21.41 9.96 51 784879 15864 109788505
Ketoacidosis 21.37 9.96 24 784906 10063 109794306
Pulmonary hypertension 21.32 9.96 270 784660 54950 109749419
Full blood count abnormal 21.30 9.96 275 784655 55777 109748592
Hyperprolactinaemia 21.26 9.96 10 784920 6565 109797804
Sputum discoloured 21.22 9.96 114 784816 27831 109776538
Atrioventricular block 21.21 9.96 56 784874 16821 109787548
Epilepsy 21.03 9.96 891 784039 99318 109705051
Transplant dysfunction 20.93 9.96 17 784913 8311 109796058
Dysphonia 20.91 9.96 396 784534 75533 109728836
Type 1 diabetes mellitus 20.89 9.96 20 784910 9027 109795342
Foot operation 20.88 9.96 105 784825 7208 109797161
Acute graft versus host disease in intestine 20.82 9.96 7 784923 5632 109798737
Bacterial sepsis 20.81 9.96 26 784904 10400 109793969
Fear of injection 20.75 9.96 121 784809 8790 109795579
Immunosuppressant drug level increased 20.63 9.96 32 784898 11692 109792677
Vascular device infection 20.59 9.96 55 784875 16457 109787912
Product dose omission issue 20.39 9.96 1986 782944 319796 109484573
Intervertebral disc degeneration 20.28 9.96 207 784723 17878 109786491
Therapeutic response decreased 20.25 9.96 858 784072 95641 109708728
Capillary leak syndrome 20.13 9.96 5 784925 4903 109799466
Bradypnoea 20.11 9.96 19 784911 8630 109795739
Hypertransaminasaemia 20.09 9.96 96 784834 24159 109780210
Joint noise 20.07 9.96 81 784849 5062 109799307
Acute lymphocytic leukaemia recurrent 19.99 9.96 8 784922 5779 109798590
Renal injury 19.97 9.96 67 784863 18646 109785723
Systemic inflammatory response syndrome 19.86 9.96 39 784891 13004 109791365
Arterial occlusive disease 19.85 9.96 50 784880 15258 109789111
Lipase increased 19.83 9.96 67 784863 18605 109785764
Lymphatic fistula 19.83 9.96 37 784893 1458 109802911
Human herpesvirus 6 infection 19.80 9.96 11 784919 6570 109797799
Ventricular extrasystoles 19.71 9.96 88 784842 22553 109781816
Skin cancer 19.68 9.96 203 784727 17581 109786788
Vascular stent thrombosis 19.67 9.96 3 784927 4158 109800211
Femoral hernia incarcerated 19.58 9.96 37 784893 1472 109802897
Salivary hypersecretion 19.55 9.96 61 784869 17360 109787009
Hydrocephalus 19.55 9.96 27 784903 10348 109794021
Ingrown hair 19.54 9.96 26 784904 762 109803607
Abdominal pain upper 19.54 9.96 2795 782135 346316 109458053
Anti-neutrophil cytoplasmic antibody positive vasculitis 19.53 9.96 7 784923 5410 109798959
Amylase increased 19.44 9.96 37 784893 12482 109791887
Metastasis 19.41 9.96 18 784912 8249 109796120
Trisomy 18 19.41 9.96 23 784907 598 109803771
Hyperphosphataemia 19.36 9.96 56 784874 16325 109788044
Purpura 19.35 9.96 98 784832 24290 109780079
Heparin-induced thrombocytopenia 19.33 9.96 32 784898 11392 109792977
Hypertriglyceridaemia 19.26 9.96 55 784875 16099 109788270
Anosmia 19.25 9.96 37 784893 12435 109791934
Post procedural infection 18.96 9.96 165 784765 13644 109790725
Linear IgA disease 18.94 9.96 4 784926 4385 109799984
Polydipsia 18.94 9.96 16 784914 7672 109796697
Skin burning sensation 18.90 9.96 85 784845 21740 109782629
Foetal exposure during pregnancy 18.85 9.96 104 784826 7401 109796968
Oesophageal carcinoma 18.84 9.96 33 784897 11491 109792878
Ileus paralytic 18.84 9.96 34 784896 11703 109792666
Weight decreased 18.80 9.96 3681 781249 464376 109339993
Body height below normal 18.76 9.96 44 784886 2040 109802329
Systemic candida 18.75 9.96 26 784904 9948 109794421
Incoherent 18.69 9.96 19 784911 8339 109796030
Laryngospasm 18.68 9.96 5 784925 4663 109799706
Breast cancer stage I 18.66 9.96 15 784915 7372 109796997
Dysgeusia 18.66 9.96 367 784563 69618 109734751
Wound infection pseudomonas 18.62 9.96 48 784882 2363 109802006
Oropharyngeal pain 18.58 9.96 1155 783775 134121 109670248
Total lung capacity decreased 18.54 9.96 14 784916 7100 109797269
Confusional state 18.53 9.96 3683 781247 464997 109339372
Temperature intolerance 18.53 9.96 45 784885 13905 109790464
Vaginal discharge 18.52 9.96 65 784865 17843 109786526
Hypotonia 18.48 9.96 54 784876 15691 109788678
Swelling face 18.48 9.96 506 784424 91815 109712554
Vertigo 18.47 9.96 472 784458 86398 109717971
Short stature 18.46 9.96 30 784900 1057 109803312
Malignant melanoma 18.31 9.96 192 784738 16699 109787670
Psychiatric decompensation 18.29 9.96 9 784921 5756 109798613
Brain injury 18.27 9.96 43 784887 13433 109790936
Breast feeding 18.18 9.96 24 784906 698 109803671
Erectile dysfunction 18.10 9.96 69 784861 18487 109785882
Pain in jaw 18.03 9.96 255 784675 50922 109753447
Congestive cardiomyopathy 18.01 9.96 47 784883 14172 109790197
Laryngeal oedema 18.00 9.96 26 784904 9781 109794588
Neurological symptom 17.98 9.96 54 784876 15554 109788815
Injection site bruising 17.97 9.96 484 784446 50779 109753590
Haematuria 17.92 9.96 450 784480 82555 109721814
Colitis ulcerative 17.88 9.96 695 784235 76668 109727701
Porphyria acute 17.85 9.96 208 784722 18572 109785797
Dyspepsia 17.84 9.96 1581 783349 189384 109614985
Depressive symptom 17.84 9.96 20 784910 8394 109795975
Cholangitis 17.77 9.96 58 784872 16277 109788092
Immune-mediated hepatitis 17.75 9.96 13 784917 6698 109797671
Hyperthyroidism 17.74 9.96 128 784802 29133 109775236
Pulmonary pain 17.72 9.96 90 784840 6203 109798166
Complications of transplanted kidney 17.71 9.96 16 784914 7426 109796943
Prostatic specific antigen increased 17.71 9.96 39 784891 12472 109791897
Eosinophil count increased 17.65 9.96 83 784847 20975 109783394
Therapy interrupted 17.64 9.96 248 784682 49574 109754795
Polyhydramnios 17.60 9.96 41 784889 1892 109802477
Injection site warmth 17.55 9.96 195 784735 17210 109787159
Neuritis 17.50 9.96 16 784914 7383 109796986
Disturbance in social behaviour 17.46 9.96 7 784923 5051 109799318
Intracranial pressure increased 17.38 9.96 30 784900 10505 109793864
Anhedonia 17.33 9.96 54 784876 15374 109788995
Long QT syndrome 17.31 9.96 15 784915 7103 109797266
Varicella zoster virus infection 17.29 9.96 12 784918 6356 109798013
Hypophagia 17.23 9.96 266 784664 52360 109752009
Hypervolaemia 17.23 9.96 247 784683 49213 109755156
Mucosal inflammation 17.22 9.96 535 784395 95606 109708763
Left ventricular dysfunction 17.20 9.96 97 784833 23396 109780973
Concomitant disease aggravated 17.19 9.96 59 784871 16305 109788064
Antibody test positive 17.18 9.96 55 784875 3065 109801304
Sudden death 17.18 9.96 102 784828 24293 109780076
Methaemoglobinaemia 17.13 9.96 24 784906 9144 109795225
Pulmonary function test abnormal 17.13 9.96 7 784923 4993 109799376
Eosinophilic granulomatosis with polyangiitis 17.11 9.96 31 784899 10655 109793714
Placental disorder 17.09 9.96 28 784902 993 109803376
Eczema 16.96 9.96 387 784543 71906 109732463
Deep vein thrombosis 16.80 9.96 816 784114 139071 109665298
Nervous system disorder 16.79 9.96 144 784786 31577 109772792
Maternal exposure during breast feeding 16.74 9.96 67 784863 4171 109800198
Herpes zoster 16.72 9.96 935 783995 107444 109696925
Personality change 16.67 9.96 33 784897 10969 109793400
Cryptococcosis 16.67 9.96 6 784924 4625 109799744
Small for dates baby 16.66 9.96 22 784908 640 109803729
Brain natriuretic peptide increased 16.66 9.96 34 784896 11175 109793194
Metastases to lymph nodes 16.61 9.96 53 784877 14979 109789390
Pseudomonal sepsis 16.59 9.96 24 784906 9022 109795347
Hypertensive crisis 16.59 9.96 103 784827 24269 109780100
Cardiac septal defect 16.56 9.96 27 784903 954 109803415
Neutrophilia 16.51 9.96 30 784900 10299 109794070
Colitis microscopic 16.41 9.96 45 784885 13349 109791020
Anticholinergic syndrome 16.36 9.96 5 784925 4275 109800094
Creatinine renal clearance increased 16.28 9.96 3 784927 3622 109800747
Electrolyte imbalance 16.25 9.96 176 784754 36852 109767517
Treatment noncompliance 16.22 9.96 394 784536 72596 109731773
Osteonecrosis 16.20 9.96 157 784773 33584 109770785
Tetany 16.15 9.96 3 784927 3601 109800768
Type I hypersensitivity 16.13 9.96 13 784917 6380 109797989
Endodontic procedure 16.12 9.96 54 784876 3082 109801287
Diaphragmatic disorder 16.09 9.96 39 784891 1847 109802522
Myoglobin blood increased 16.07 9.96 5 784925 4227 109800142
Activated partial thromboplastin time prolonged 16.03 9.96 93 784837 22275 109782094
Antineutrophil cytoplasmic antibody positive 15.99 9.96 8 784922 5068 109799301
Lower respiratory tract congestion 15.98 9.96 72 784858 4724 109799645
Post-traumatic stress disorder 15.92 9.96 14 784916 6582 109797787
Syringe issue 15.83 9.96 27 784903 9498 109794871
Benign ovarian tumour 15.80 9.96 18 784912 448 109803921
Mood altered 15.79 9.96 88 784842 21287 109783082
Chronic obstructive pulmonary disease 15.74 9.96 624 784306 108534 109695835
Stillbirth 15.72 9.96 66 784864 4198 109800171
Hepatitis C 15.59 9.96 42 784888 12531 109791838
Blood glucose decreased 15.55 9.96 134 784796 29354 109775015
Breast cancer stage II 15.53 9.96 277 784653 27098 109777271
Gait disturbance 15.52 9.96 2227 782703 275981 109528388
Foetal distress syndrome 15.52 9.96 21 784909 626 109803743
Incorrect dose administered 15.48 9.96 590 784340 103051 109701318
Catarrh 15.42 9.96 97 784833 7238 109797131
Staphylococcal infection 15.42 9.96 378 784552 69566 109734803
Swollen joint count 15.41 9.96 110 784820 8564 109795805
Device loosening 15.34 9.96 24 784906 818 109803551
Osteopenia 15.30 9.96 232 784698 21977 109782392
Hepatitis B 15.29 9.96 28 784902 9584 109794785
Radiation inflammation 15.25 9.96 27 784903 1021 109803348
Hyperventilation 15.20 9.96 25 784905 8922 109795447
Infection reactivation 15.18 9.96 5 784925 4076 109800293
Dyslipidaemia 15.17 9.96 60 784870 15905 109788464
Infusion site reaction 15.14 9.96 192 784738 17490 109786879
Device occlusion 15.12 9.96 56 784874 15129 109789240
Accidental overdose 15.00 9.96 268 784662 51566 109752803
Drug screen positive 15.00 9.96 14 784916 6396 109797973
Complication of device removal 14.98 9.96 7 784923 4613 109799756
Ear pain 14.97 9.96 489 784441 52737 109751632
Bone density increased 14.95 9.96 26 784904 969 109803400
Compartment syndrome 14.93 9.96 12 784918 5898 109798471
Hypertension 14.81 9.96 3952 780978 506132 109298237
Extra dose administered 14.79 9.96 41 784889 12118 109792251
Haemorrhage in pregnancy 14.78 9.96 35 784895 1633 109802736
Taste disorder 14.78 9.96 586 784344 64801 109739568
Atrial flutter 14.77 9.96 106 784824 24156 109780213
Extravascular haemolysis 14.74 9.96 17 784913 429 109803940
Total lung capacity increased 14.74 9.96 9 784921 5103 109799266
Eyelid oedema 14.73 9.96 57 784873 15205 109789164
Sickle cell anaemia 14.70 9.96 23 784907 784 109803585
Placental insufficiency 14.70 9.96 30 784900 1264 109803105
Aspiration 14.69 9.96 142 784788 30391 109773978
Extradural haematoma 14.69 9.96 3 784927 3366 109801003
Metabolic disorder 14.68 9.96 33 784897 10477 109793892
Plasma cell myeloma recurrent 14.65 9.96 17 784913 7025 109797344
Panic attack 14.60 9.96 133 784797 28807 109775562
Anal fissure 14.59 9.96 120 784810 9761 109794608
Clostridium test positive 14.58 9.96 35 784895 10858 109793511
Cushingoid 14.58 9.96 137 784793 11575 109792794
Nail injury 14.57 9.96 23 784907 790 109803579
Genital haemorrhage 14.56 9.96 18 784912 7234 109797135
Impaired gastric emptying 14.54 9.96 47 784883 13228 109791141
Ligament rupture 14.53 9.96 62 784868 3973 109800396
Intraocular pressure increased 14.51 9.96 35 784895 10841 109793528
Cyst 14.50 9.96 180 784750 16316 109788053
Injection site swelling 14.49 9.96 556 784374 61234 109743135
Epstein-Barr virus associated lymphoproliferative disorder 14.49 9.96 8 784922 4794 109799575
Haematocrit decreased 14.35 9.96 590 784340 65527 109738842
Asthenia 14.32 9.96 4522 780408 684477 109119892
Pharyngeal swelling 14.32 9.96 41 784889 11991 109792378
Insurance issue 14.28 9.96 34 784896 10578 109793791
Autonomic nervous system imbalance 14.27 9.96 12 784918 5768 109798601
Hypoglycaemic coma 14.27 9.96 11 784919 5522 109798847
Bronchial secretion retention 14.27 9.96 9 784921 5015 109799354
Head injury 14.23 9.96 217 784713 42800 109761569
Central nervous system mass 14.14 9.96 23 784907 811 109803558
Steroid diabetes 14.13 9.96 10 784920 5244 109799125
Bone density abnormal 14.07 9.96 60 784870 3843 109800526
Oral candidiasis 14.06 9.96 228 784702 44532 109759837
Hepatic cancer 14.03 9.96 37 784893 11119 109793250
Neoplasm recurrence 14.02 9.96 10 784920 5222 109799147
Injection site rash 14.02 9.96 239 784691 23180 109781189
Epstein-Barr viraemia 14.01 9.96 4 784926 3575 109800794
Wall motion score index abnormal 13.99 9.96 23 784907 818 109803551
Hepatic necrosis 13.99 9.96 31 784899 9891 109794478
Spinal osteoarthritis 13.97 9.96 211 784719 19972 109784397
Retinal haemorrhage 13.96 9.96 29 784901 9472 109794897
Nervousness 13.93 9.96 181 784749 36670 109767699
Mitochondrial toxicity 13.92 9.96 3 784927 3242 109801127
Enterococcal infection 13.90 9.96 86 784844 20280 109784089
Staphylococcal bacteraemia 13.85 9.96 66 784864 16622 109787747
Blood potassium increased 13.82 9.96 160 784770 33089 109771280
Coeliac disease 13.81 9.96 403 784527 42784 109761585
Bradyarrhythmia 13.79 9.96 9 784921 4925 109799444
Pancreatic steatosis 13.79 9.96 36 784894 1786 109802583
Lymph gland infection 13.78 9.96 20 784910 637 109803732
Lacrimal disorder 13.78 9.96 18 784912 518 109803851
Mental impairment 13.74 9.96 99 784831 22540 109781829
Blood folate increased 13.72 9.96 19 784911 579 109803790
Multiple allergies 13.72 9.96 43 784887 12220 109792149
Behaviour disorder 13.72 9.96 30 784900 9617 109794752
Cytomegalovirus colitis 13.69 9.96 18 784912 7043 109797326
Induced labour 13.64 9.96 24 784906 903 109803466
Accidental exposure to product by child 13.63 9.96 3 784927 3195 109801174
Heart rate irregular 13.60 9.96 329 784601 33945 109770424
Back pain 13.56 9.96 2371 782559 368625 109435744
Hypovolaemia 13.53 9.96 94 784836 21580 109782789
Cervical incompetence 13.49 9.96 18 784912 529 109803840
Obsessive-compulsive disorder 13.49 9.96 19 784911 7222 109797147
Bone marrow failure 13.48 9.96 310 784620 57538 109746831
Gastric cancer 13.48 9.96 37 784893 10971 109793398
Corneal oedema 13.47 9.96 3 784927 3170 109801199
Iritis 13.43 9.96 67 784863 4585 109799784
Immune thrombocytopenia 13.35 9.96 99 784831 22395 109781974
Hypoventilation 13.34 9.96 23 784907 8058 109796311
Acute lung injury 13.34 9.96 3 784927 3148 109801221
Cyst rupture 13.32 9.96 23 784907 852 109803517
Wrong product administered 13.30 9.96 37 784893 10923 109793446
Hand fracture 13.29 9.96 101 784829 8021 109796348
Cerebral toxoplasmosis 13.28 9.96 3 784927 3139 109801230
Vasculitis 13.26 9.96 177 784753 35696 109768673
Sneezing 13.26 9.96 154 784776 31830 109772539
Troponin T increased 13.25 9.96 7 784923 4299 109800070
Vein disorder 13.24 9.96 83 784847 6187 109798182
Hallucinations, mixed 13.23 9.96 26 784904 8667 109795702
Lower gastrointestinal haemorrhage 13.17 9.96 77 784853 18409 109785960
Lip oedema 13.13 9.96 21 784909 7579 109796790
Respiratory tract infection 13.11 9.96 628 784302 70989 109733380
Pneumonia fungal 13.05 9.96 57 784873 14697 109789672
Drooling 13.03 9.96 19 784911 7120 109797249
Renal cancer 13.02 9.96 48 784882 12986 109791383
Bronchopulmonary aspergillosis allergic 13.00 9.96 25 784905 8401 109795968
Delayed graft function 12.98 9.96 7 784923 4250 109800119
Cardiac dysfunction 12.97 9.96 15 784915 6208 109798161
Pain of skin 12.94 9.96 86 784844 19943 109784426
Spinal cord compression 12.92 9.96 21 784909 7531 109796838
Granulocyte count decreased 12.92 9.96 6 784924 3968 109800401
Medication error 12.91 9.96 891 784039 104475 109699894
Reversible cerebral vasoconstriction syndrome 12.89 9.96 9 784921 4752 109799617
Blood loss anaemia 12.89 9.96 75 784855 17950 109786419
Nightmare 12.87 9.96 196 784734 38667 109765702
Abortion incomplete 12.85 9.96 3 784927 3069 109801300
Mitral valve incompetence 12.85 9.96 163 784767 33166 109771203
Tumour haemorrhage 12.82 9.96 11 784919 5234 109799135
Joint lock 12.82 9.96 55 784875 3533 109800836
Pseudomembranous colitis 12.69 9.96 16 784914 6375 109797994
Injection site extravasation 12.68 9.96 119 784811 10050 109794319
Nystagmus 12.67 9.96 41 784889 11536 109792833
Upper gastrointestinal haemorrhage 12.67 9.96 265 784665 49831 109754538
Kounis syndrome 12.66 9.96 14 784916 5911 109798458
Blood uric acid increased 12.66 9.96 95 784835 21434 109782935
Transient aphasia 12.63 9.96 20 784910 689 109803680
Dysuria 12.61 9.96 328 784602 59903 109744466
Pharyngitis streptococcal 12.60 9.96 147 784783 13130 109791239
Defaecation disorder 12.59 9.96 22 784908 823 109803546
Anger 12.59 9.96 81 784849 18926 109785443
Plasma cell myeloma 12.58 9.96 345 784585 62591 109741778
Burns second degree 12.56 9.96 96 784834 7637 109796732
Swollen tongue 12.56 9.96 329 784601 60033 109744336
Secondary adrenocortical insufficiency 12.52 9.96 8 784922 4426 109799943
Oligoarthritis 12.51 9.96 21 784909 760 109803609
Nephrotic syndrome 12.50 9.96 53 784877 13778 109790591
Human anti-human antibody test 12.48 9.96 15 784915 396 109803973
Lymphoedema 12.42 9.96 59 784871 14870 109789499
Renal tubular disorder 12.40 9.96 21 784909 7408 109796961
Musculoskeletal disorder 12.39 9.96 228 784702 22436 109781933
Areflexia 12.37 9.96 18 784912 6751 109797618
Fungaemia 12.33 9.96 15 784915 6071 109798298
C-reactive protein decreased 12.31 9.96 47 784883 2862 109801507
Urinary incontinence 12.29 9.96 257 784673 48330 109756039
Hypopituitarism 12.28 9.96 8 784922 4382 109799987
Tender joint count increased 12.28 9.96 15 784915 403 109803966
Dactylitis 12.27 9.96 60 784870 4073 109800296
Cough 12.24 9.96 2998 781932 458643 109345726
Complication of device insertion 12.15 9.96 28 784902 8810 109795559
Viraemia 12.14 9.96 7 784923 4095 109800274
Enterobacter infection 12.12 9.96 14 784916 5797 109798572
Threatened labour 12.12 9.96 19 784911 649 109803720
Airway remodelling 12.10 9.96 23 784907 919 109803450
Ataxia 12.08 9.96 146 784784 29962 109774407
Hypertonia 12.07 9.96 26 784904 8380 109795989
Rhinovirus infection 12.05 9.96 43 784887 11746 109792623
Epstein-Barr virus infection reactivation 12.04 9.96 7 784923 4077 109800292
Frequent bowel movements 12.03 9.96 621 784309 70769 109733600
Crying 11.99 9.96 120 784810 25508 109778861
Productive cough 11.98 9.96 676 784254 113629 109690740
Dermatitis bullous 11.97 9.96 74 784856 17455 109786914
Wrong patient received product 11.95 9.96 18 784912 6656 109797713
Leukoencephalopathy 11.95 9.96 30 784900 9165 109795204
Fanconi syndrome 11.94 9.96 5 784925 3514 109800855
Post procedural haemorrhage 11.93 9.96 63 784867 15449 109788920
Liver abscess 11.91 9.96 23 784907 7716 109796653
Bone fissure 11.89 9.96 18 784912 596 109803773
Dermatitis exfoliative 11.86 9.96 41 784889 11306 109793063
Ulcer 11.84 9.96 395 784535 42721 109761648
Vascular purpura 11.79 9.96 6 784924 3765 109800604
Pneumomediastinum 11.78 9.96 11 784919 5025 109799344
Labyrinthitis 11.77 9.96 48 784882 3014 109801355
Breast cancer female 11.75 9.96 47 784883 12421 109791948
Joint warmth 11.74 9.96 37 784893 2045 109802324
Cardiopulmonary failure 11.72 9.96 24 784906 7879 109796490
Product monitoring error 11.70 9.96 29 784901 8898 109795471
Device breakage 11.70 9.96 54 784876 13715 109790654
Parvovirus B19 infection 11.69 9.96 3 784927 2878 109801491
Sleep disorder therapy 11.67 9.96 22 784908 7449 109796920
Pupillary reflex impaired 11.67 9.96 7 784923 4008 109800361
Clonus 11.67 9.96 28 784902 8688 109795681
Immunisation 11.67 9.96 4 784926 3179 109801190
Carcinoid tumour of the small bowel 11.66 9.96 15 784915 425 109803944
Infusion site pain 11.66 9.96 74 784856 17345 109787024
Oxygen saturation decreased 11.64 9.96 1279 783651 155703 109648666
Paronychia 11.61 9.96 40 784890 11041 109793328
Skin weeping 11.60 9.96 6 784924 3729 109800640
Arteriospasm coronary 11.58 9.96 30 784900 9070 109795299
Poor quality device used 11.58 9.96 3 784927 2860 109801509
Arteriosclerosis 11.57 9.96 116 784814 24651 109779718
Oesophageal fibrosis 11.57 9.96 10 784920 176 109804193
Hyporesponsive to stimuli 11.56 9.96 3 784927 2857 109801512
Embolism 11.53 9.96 68 784862 16221 109788148
Osteoporotic fracture 11.49 9.96 71 784859 5266 109799103
Hypothalamo-pituitary disorder 11.48 9.96 3 784927 2843 109801526
Product dose omission in error 11.46 9.96 109 784821 23403 109780966
Terminal state 11.45 9.96 14 784916 5653 109798716
Brain abscess 11.44 9.96 19 784911 6755 109797614
Increased appetite 11.42 9.96 61 784869 14916 109789453
Cogwheel rigidity 11.39 9.96 6 784924 3692 109800677
Schizoaffective disorder 11.39 9.96 4 784926 3132 109801237
Uveitis 11.38 9.96 217 784713 21493 109782876
Quadriparesis 11.35 9.96 10 784920 4697 109799672
Aphthous ulcer 11.34 9.96 212 784718 20924 109783445
Prerenal failure 11.33 9.96 9 784921 4450 109799919
Tooth disorder 11.33 9.96 282 784648 29227 109775142
Drug abuser 11.31 9.96 13 784917 5396 109798973
Feeding disorder 11.30 9.96 97 784833 21265 109783104
Tension headache 11.28 9.96 33 784897 9585 109794784
Skin necrosis 11.27 9.96 215 784715 21297 109783072
Choking 11.27 9.96 62 784868 15048 109789321
Muscle spasticity 11.26 9.96 183 784747 35732 109768637
Alcohol abuse 11.26 9.96 11 784919 4918 109799451
Myofascial pain syndrome 11.24 9.96 42 784888 2531 109801838
Clear cell renal cell carcinoma 11.23 9.96 44 784886 2712 109801657
Cold sweat 11.22 9.96 101 784829 21930 109782439
Cystoid macular oedema 11.20 9.96 3 784927 2797 109801572
Liver transplant rejection 11.15 9.96 7 784923 3911 109800458
Pneumonitis 11.14 9.96 437 784493 76094 109728275
Erythema of eyelid 11.14 9.96 7 784923 3908 109800461
Fibroadenoma of breast 11.08 9.96 19 784911 700 109803669
Rash morbilliform 11.08 9.96 25 784905 7926 109796443
Cardiac tamponade 11.06 9.96 42 784888 11265 109793104
Tubulointerstitial nephritis 11.00 9.96 297 784633 53987 109750382
Eye movement disorder 10.96 9.96 34 784896 9694 109794675
Abortion threatened 10.96 9.96 15 784915 452 109803917
Hypochloraemia 10.96 9.96 6 784924 3612 109800757
Mycobacterium chelonae infection 10.95 9.96 4 784926 3056 109801313
Subileus 10.92 9.96 18 784912 6419 109797950
Autoimmune hepatitis 10.90 9.96 61 784869 14743 109789626
Anaesthetic complication 10.89 9.96 6 784924 3600 109800769
Haemorrhage subcutaneous 10.86 9.96 14 784916 5525 109798844
Thirst 10.85 9.96 100 784830 21607 109782762
Skin graft failure 10.84 9.96 11 784919 239 109804130
Inadequate analgesia 10.84 9.96 12 784918 5065 109799304
Haemorrhagic transformation stroke 10.82 9.96 4 784926 3033 109801336
Breast abscess 10.81 9.96 32 784898 1709 109802660
Blood phosphorus decreased 10.76 9.96 24 784906 7641 109796728
Tumour marker increased 10.76 9.96 12 784918 5048 109799321
Knee operation 10.76 9.96 86 784844 6936 109797433
Lung transplant 10.74 9.96 13 784917 5273 109799096
Neutrophil count increased 10.72 9.96 177 784753 34475 109769894
Disorganised speech 10.72 9.96 5 784925 3298 109801071
Throat tightness 10.72 9.96 170 784760 33319 109771050
Tuberculin test positive 10.71 9.96 53 784877 3615 109800754
Oculogyric crisis 10.70 9.96 7 784923 3825 109800544
Brain herniation 10.69 9.96 30 784900 8833 109795536
Hypoproteinaemia 10.68 9.96 16 784914 5929 109798440
Malnutrition 10.67 9.96 133 784797 27146 109777223
Peritoneal dialysis complication 10.66 9.96 41 784889 2505 109801864
Twin pregnancy 10.63 9.96 22 784908 936 109803433
Impaired work ability 10.60 9.96 254 784676 26165 109778204
Lip and/or oral cavity cancer 10.58 9.96 25 784905 1165 109803204
Pancreatic carcinoma 10.57 9.96 62 784868 14810 109789559
Apraxia 10.53 9.96 6 784924 3534 109800835
Cancer pain 10.53 9.96 20 784910 6752 109797617
Injection site haemorrhage 10.50 9.96 308 784622 32720 109771649
Device issue 10.49 9.96 177 784753 34358 109770011
Renal disorder 10.47 9.96 269 784661 49210 109755159
CD4 lymphocytes decreased 10.46 9.96 4 784926 2970 109801399
Middle insomnia 10.44 9.96 94 784836 20408 109783961
Catatonia 10.40 9.96 43 784887 11257 109793112
Lip blister 10.40 9.96 49 784881 3276 109801093
Angina unstable 10.39 9.96 71 784859 16361 109788008
Hospitalisation 10.39 9.96 870 784060 141623 109662746
Pancreatitis 10.39 9.96 550 784380 92983 109711386
Candida sepsis 10.38 9.96 4 784926 2957 109801412
Swollen joint count decreased 10.34 9.96 13 784917 360 109804009
Tonic clonic movements 10.33 9.96 4 784926 2948 109801421
Vertebral osteophyte 10.32 9.96 16 784914 541 109803828
Immune-mediated myocarditis 10.31 9.96 6 784924 3492 109800877
Mesothelioma 10.31 9.96 13 784917 361 109804008
Persecutory delusion 10.30 9.96 18 784912 6273 109798096
Joint ankylosis 10.28 9.96 40 784890 2457 109801912
Staphylococcal sepsis 10.27 9.96 77 784853 17377 109786992
Tooth abscess 10.27 9.96 189 784741 18600 109785769
Abortion missed 10.26 9.96 29 784901 1508 109802861
Vacuum extractor delivery 10.26 9.96 8 784922 121 109804248
Hypovolaemic shock 10.25 9.96 61 784869 14522 109789847
Post procedural haematoma 10.24 9.96 3 784927 2636 109801733
Resuscitation 10.22 9.96 4 784926 2929 109801440
Hereditary angioedema 10.22 9.96 22 784908 7092 109797277
Nasal obstruction 10.21 9.96 49 784881 3301 109801068
Gastric ulcer haemorrhage 10.20 9.96 37 784893 10057 109794312
Hepatitis E antibody positive 10.17 9.96 11 784919 258 109804111
Apnoea 10.16 9.96 56 784874 13583 109790786
Analgesic therapy 10.07 9.96 23 784907 7261 109797108
Transfusion-related circulatory overload 10.05 9.96 21 784909 900 109803469
Unevaluable event 10.02 9.96 332 784598 58895 109745474
Atopy 9.99 9.96 24 784906 1130 109803239
Tooth infection 9.98 9.96 217 784713 21999 109782370
Alcohol interaction 9.98 9.96 7 784923 3687 109800682

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000276 Adjuvants, Immunologic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D016588 Anticarcinogenic Agents
MeSH PA D020011 Protective Agents
MeSH PA D014815 Vitamins
MeSH PA D018977 Micronutrients
CHEBI has role CHEBI:77746 human metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Retinol-binding protein 4 Secreted Kd 6.74 CHEMBL
Amyloid beta A4 protein Membrane other IC50 6.75 CHEMBL
Alpha-synuclein Transporter IC50 6.72 CHEMBL
Beta-lactoglobulin Secreted Kd 7.44 CHEMBL

External reference:

IDSource
4017713 VUID
N0000179229 NUI
D01621 KEGG_DRUG
4017637 VANDF
4017648 VANDF
4017713 VANDF
4021164 VANDF
C0073109 UMLSCUI
CHEBI:32095 CHEBI
RTL PDB_CHEM_ID
CHEMBL486193 ChEMBL_ID
CHEMBL4297637 ChEMBL_ID
C009166 MESH_SUPPLEMENTAL_RECORD_UI
638034 PUBCHEM_CID
DB00162 DRUGBANK_ID
11246 RXNORM
232172 MMSL
5678 MMSL
975 MMSL
d00402 MMSL
001000 NDDF
001001 NDDF
421621000 SNOMEDCT_US
82156005 SNOMEDCT_US
82622003 SNOMEDCT_US
C0042839 UMLSCUI
445354 PUBCHEM_CID
2243 INN_ID
D014801 MESH_DESCRIPTOR_UI
3LE3D9D6OY UNII
CHEBI:45479 CHEBI
3LE3D9D6OY INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 1100 [iU] ORAL UNAPPROVED DRUG OTHER 14 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 1100 [iU] ORAL UNAPPROVED DRUG OTHER 13 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 2000 [iU] ORAL UNAPPROVED DRUG OTHER 10 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 3080 [iU] ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 3080 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-100 LIQUID 1000 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-101 LIQUID 1100 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-103 TABLET, CHEWABLE 1200 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-104 TABLET, CHEWABLE 1200 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-105 TABLET, CHEWABLE 1200 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 17856-0668 TABLET, FILM COATED 3080 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Prenatal Plus Vitamins HUMAN PRESCRIPTION DRUG LABEL 15 39328-106 TABLET 924 ug ORAL UNAPPROVED DRUG OTHER 7 sections
PNV-Select HUMAN PRESCRIPTION DRUG LABEL 18 42192-320 TABLET, FILM COATED 2500 [iU] ORAL unapproved drug other 10 sections
PNV Prenatal VitaminPlus Vitamin A HUMAN PRESCRIPTION DRUG LABEL 12 44946-1046 TABLET 2500 [iU] ORAL UNAPPROVED DRUG OTHER 9 sections
Prenatal Vitamins Plus Low Iron HUMAN PRESCRIPTION DRUG LABEL 15 50090-0616 TABLET 924 ug ORAL UNAPPROVED DRUG OTHER 8 sections
PNV Prenatal Plus Multivitamin HUMAN PRESCRIPTION DRUG LABEL 15 50090-0617 TABLET 2000 [iU] ORAL Unapproved drug other 9 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-173 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-174 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-177 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
Multitol-M HUMAN PRESCRIPTION DRUG LABEL 17 59088-005 TABLET 1500 ug ORAL unapproved drug other 11 sections
Finazol HUMAN PRESCRIPTION DRUG LABEL 24 59088-008 TABLET 1500 ug ORAL unapproved drug other 13 sections
Prenatol-M HUMAN PRESCRIPTION DRUG LABEL 20 59088-009 TABLET 1500 ug ORAL unapproved drug other 13 sections
Vitalux HUMAN PRESCRIPTION DRUG LABEL 20 59088-139 TABLET 1500 ug ORAL unapproved drug other 13 sections
Davimet with Iron HUMAN PRESCRIPTION DRUG LABEL 12 59088-160 TABLET 750 ug ORAL unapproved drug other 13 sections
Vitrexyl HUMAN PRESCRIPTION DRUG LABEL 17 59088-164 TABLET 1500 ug ORAL unapproved drug other 11 sections
Vitrexyl plus Iron HUMAN PRESCRIPTION DRUG LABEL 18 59088-165 TABLET 1500 ug ORAL unapproved drug other 13 sections
Prenatrix HUMAN PRESCRIPTION DRUG LABEL 20 59088-166 TABLET 1500 ug ORAL unapproved drug other 13 sections
Vitrexate HUMAN PRESCRIPTION DRUG LABEL 17 59088-167 TABLET 1500 ug ORAL unapproved drug other 11 sections
Vitrexate FE HUMAN PRESCRIPTION DRUG LABEL 18 59088-168 TABLET 1500 ug ORAL unapproved drug other 13 sections
Prenatryl HUMAN PRESCRIPTION DRUG LABEL 20 59088-169 TABLET 1500 ug ORAL unapproved drug other 13 sections