retinol acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
retinol derivatives	2372	127-47-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: retinyl acetate QLT091001 retinol acetate Vitamin A acetate	Molecular weight: 328.50 Formula: C22H32O2 CLOGP: 7.35 LIPINSKI: 1 HAC: 2 HDO: 0 TPSA: 26.30 ALOGS: -5.14 ROTB: 7

Molecule

Description

Molfile Inchi Smiles

Synonyms:

retinyl acetate
QLT091001
retinol acetate
Vitamin A acetate

Molecular weight: 328.50
Formula: C22H32O2
CLOGP: 7.35
LIPINSKI: 1
HAC: 2
HDO: 0
TPSA: 26.30
ALOGS: -5.14
ROTB: 7

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pemphigus	2026.52	10.35	4403	483393	179323	62821903
Systemic lupus erythematosus	1923.53	10.35	4662	483134	204256	62796970
Glossodynia	1696.80	10.35	4039	483757	174837	62826389
Hand deformity	1399.19	10.35	3495	484301	155962	62845264
Arthropathy	1301.92	10.35	4364	483432	230428	62770798
Abdominal discomfort	1178.81	10.35	5233	482563	315652	62685574
Alopecia	1176.94	10.35	5420	482376	332116	62669110
Wound	1160.45	10.35	3310	484486	159953	62841273
Maternal exposure during pregnancy	1053.71	10.35	3898	483898	216164	62785062
Rheumatoid arthritis	1048.76	10.35	4291	483505	249528	62751698

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rheumatoid arthritis	636.97	10.28	823	156842	37415	34761851
Foetal exposure during pregnancy	327.65	10.28	604	157061	37497	34761769
Drug abuse	313.36	10.28	39	157626	99057	34700209
Arthralgia	271.51	10.28	1495	156170	168546	34630720
Toxicity to various agents	259.93	10.28	313	157352	200049	34599217
Completed suicide	224.59	10.28	81	157584	98087	34701179
Psoriatic arthropathy	208.11	10.28	343	157322	19455	34779811
Sickle cell anaemia with crisis	159.28	10.28	138	157527	3915	34795351
Joint swelling	154.14	10.28	606	157059	59284	34739982
Dysmorphism	143.73	10.28	117	157548	3039	34796227

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rheumatoid arthritis	1415.53	9.95	3603	485141	204867	79050777
Arthropathy	1124.74	9.95	2986	485758	174125	79081519
Systemic lupus erythematosus	1101.53	9.95	2349	486395	118800	79136844
Pemphigus	1100.15	9.95	2094	486650	97488	79158156
Joint swelling	1092.23	9.95	4066	484678	284580	78971064
Hand deformity	1070.98	9.95	2122	486622	101797	79153847
Synovitis	1067.31	9.95	2648	486096	148086	79107558
Completed suicide	1037.97	9.95	139	488605	245628	79010016
Glossodynia	958.20	9.95	2020	486724	101317	79154327
Toxicity to various agents	910.62	9.95	749	487995	420791	78834853

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
MeSH PA	D000276	Adjuvants, Immunologic
MeSH PA	D016588	Anticarcinogenic Agents
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D007155	Immunologic Factors
MeSH PA	D020011	Protective Agents
MeSH PA	D018977	Micronutrients
MeSH PA	D014815	Vitamins

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Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Retinol-binding protein 4	Secreted	P02753	RET4_HUMAN	Kd	6.74	CHEMBL
Amyloid beta A4 protein	Unclassified	P05067	A4_HUMAN	IC50	6.75	CHEMBL
Alpha-synuclein	Transporter	P37840	SYUA_HUMAN	IC50	6.72	CHEMBL
Beta-lactoglobulin	Unclassified		LACB_BOVIN	Kd	7.44	CHEMBL

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External reference:

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ID	Source
RTL	PDB_CHEM_ID
001000	NDDF
001001	NDDF
11246	RXNORM
2243	INN_ID
232172	MMSL
3LE3D9D6OY	UNII
4017637	VANDF
4017648	VANDF
4017713	VUID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
BACMIN	HUMAN PRESCRIPTION DRUG LABEL	19	0682-3001	TABLET, COATED	2000 [iU]	ORAL	UNAPPROVED DRUG OTHER	10 sections
Escavite	HUMAN PRESCRIPTION DRUG LABEL	17	58809-888	TABLET, CHEWABLE	1000 [iU]	ORAL	UNAPPROVED DRUG OTHER	10 sections
Floriva	HUMAN PRESCRIPTION DRUG LABEL	16	52796-173	TABLET, CHEWABLE	1000 [iU]	ORAL	UNAPPROVED DRUG OTHER	6 sections
Floriva	HUMAN PRESCRIPTION DRUG LABEL	16	52796-174	TABLET, CHEWABLE	1000 [iU]	ORAL	UNAPPROVED DRUG OTHER	6 sections
Floriva	HUMAN PRESCRIPTION DRUG LABEL	16	52796-177	TABLET, CHEWABLE	1000 [iU]	ORAL	UNAPPROVED DRUG OTHER	7 sections
PNV Prenatal Plus Multivitamin	HUMAN PRESCRIPTION DRUG LABEL	15	50090-0617	TABLET	2000 [iU]	ORAL	Unapproved drug other	9 sections
PNV Prenatal VitaminPlus Vitamin A	HUMAN PRESCRIPTION DRUG LABEL	12	44946-1046	TABLET	2500 [iU]	ORAL	UNAPPROVED DRUG OTHER	9 sections
PNV-Select	HUMAN PRESCRIPTION DRUG LABEL	18	42192-320	TABLET, FILM COATED	2500 [iU]	ORAL	unapproved drug other	10 sections
Poly-ViFlor	HUMAN PRESCRIPTION DRUG LABEL	11	42494-432	TABLET, CHEWABLE	600 ug	ORAL	Unapproved drug other	6 sections
Poly-ViFlor	HUMAN PRESCRIPTION DRUG LABEL	11	42494-433	TABLET, CHEWABLE	600 ug	ORAL	Unapproved drug other	6 sections

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