piromidic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibacterials, nalidixic acid derivatives 2209 19562-30-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • piromidic acid
  • pyromidic acid
Antibacterial against mainly gram negative organisms. It is used for urinary tract and intestinal infections.
  • Molecular weight: 288.31
  • Formula: C14H16N4O3
  • CLOGP: 0.99
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 86.63
  • ALOGS: -2.38
  • ROTB: 3

Drug dosage:

DoseUnitRoute
2 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.353 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.059 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 161.808 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 17.539 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 21.950 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 28.050 % High 1
herg hERG pIC50 4.063 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 2.173 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 7.674 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 7.930 % High 1
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,MAP3K21,MAPK7,NTRK2,PDK1,PDK2,PRKDC,SIK2,STK33,TEK 20
kinase-selectivity-class ACVR2A,ACVR2B,AXL,BRAF,CDK9,DYRK1B,EIF2AK3,GRK2,MAP2K6,MAPK7,PRKDC,SIK2,STK33,TEK,TGFBR1,TTK 16
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 3.581 High 1
mh-clint Mouse hepatocyte intrinsic clearance 34.995 High 1
mppb Mouse plasma protein binding (% unbound) 14.720 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 2.317 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 8.750 % High 1
rh-clint Rat hepatocyte intrinsic clearance 10.162 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 92.370 % High 1
rppb Rat plasma protein binding (% unbound) 3.650 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 920.450 uM High 1

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01MB03 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
QUINOLONE ANTIBACTERIALS
Other quinolones
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000892 Anti-Infective Agents, Urinary
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:59517 DNA synthesis inhibitor

Related Drugs by ATC class:

J01MB Other quinolones 7 drugs
cinoxacinflumequinenalidixic acidnemonoxacinoxolinic acidpipemidic acidrosoxacin

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.55 acidic
pKa2 6.43 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01431 KEGG_DRUG
C0031987 UMLSCUI
CHEBI:32019 CHEBI
CHEMBL311350 ChEMBL_ID
DB13744 DRUGBANK_ID
D010893 MESH_DESCRIPTOR_UI
4855 PUBCHEM_CID
12475 IUPHAR_LIGAND_ID
3198 INN_ID
3I12WH4EWF UNII

Pharmaceutical products:

None