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pipemidic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibacterials, nalidixic acid derivatives | 2184 | 51940-44-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Antimicrobial against Gram negative and some Gram positive bacteria. It is protein bound and concentrated in bile and urine and used for gastrointestinal, biliary, and urinary infections.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.80 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 93 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.88 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 2.84 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.70 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 3.69 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | -1.405 | High | 0.81 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 2.512 | High | 0.81 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 1.766 | 10^-6 cm/s | High | 0.81 |
| dh-clint | Dog hepatocyte intrinsic clearance | 1.493 | uL/min/10^6 cells | High | 0.81 |
| dppb | Dog plasma protein binding (% unbound) | 88.590 | % | High | 0.81 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 90.700 | % | High | 0.81 |
| herg | hERG pIC50 | 4.597 | pIC50 | High | 0.81 |
| hh-clint | Human hepatocyte intrinsic clearance | 1.119 | uL/min/10^6 cells | High | 0.81 |
| hlm-clint | Human liver microsomal intrinsic clearance | 3.126 | uL/min/mg protein | High | 0.81 |
| hppb | Human plasma protein binding (% unbound) | 83.370 | % | High | 0.81 |
| kinase-safety-class | ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAPK7,PDK1,PDK2,PRKDC,TEK | 16 | |||
| kinase-selectivity-class | ACVR2B,AXL,BRAF,CDK9,DYRK1B,EIF2AK3,GRK2,MAP2K6,MAPK7,PRKDC,STK33,TEK,TTK | 13 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 5.585 | High | 0.81 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 3.141 | High | 0.81 | |
| mppb | Mouse plasma protein binding (% unbound) | 90.600 | High | 0.81 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 5.483 | High | 0.81 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 92.480 | % | High | 0.81 |
| rh-clint | Rat hepatocyte intrinsic clearance | 1.167 | uL/min/10^6 cells | High | 0.81 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 92.070 | % | High | 0.81 |
| rppb | Rat plasma protein binding (% unbound) | 77.740 | % | High | 0.81 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 855.067 | uM | High | 0.81 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01MB04 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE QUINOLONE ANTIBACTERIALS Other quinolones |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000892 | Anti-Infective Agents, Urinary |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
| CHEBI has role | CHEBI:36047 | antibacterial drug |
| CHEBI has role | CHEBI:59517 | DNA synthesis inhibitor |
Related Drugs by ATC class:
J01MB Other quinolones 7 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.55 | acidic |
| pKa2 | 8.04 | Basic |
| pKa3 | 6.43 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| N0000167334 | NUI |
| D08379 | KEGG_DRUG |
| C0031953 | UMLSCUI |
| CHEBI:75250 | CHEBI |
| CHEMBL30116 | ChEMBL_ID |
| DB13823 | DRUGBANK_ID |
| D010876 | MESH_DESCRIPTOR_UI |
| 4831 | PUBCHEM_CID |
| 12774 | IUPHAR_LIGAND_ID |
| 3694 | INN_ID |
| LT12J5HVR8 | UNII |
| 8337 | RXNORM |
| 004201 | NDDF |
| 702807004 | SNOMEDCT_US |
| 96079005 | SNOMEDCT_US |
Pharmaceutical products:
None