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oxolinic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibacterials, nalidixic acid derivatives | 2024 | 14698-29-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Synthetic antimicrobial related to NALIDIXIC ACID and used in URINARY TRACT INFECTIONS.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1 | g | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 0.383 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.798 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 82.604 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 5.794 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 46.090 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 54.360 | % | High | 1 |
| herg | hERG pIC50 | 4.456 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 1.387 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 3.945 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 26.770 | % | High | 1 |
| kinase-safety-class | ACVR2A,ACVR2B,AURKA,AXL,BRAF,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,GRK2,MAP3K21,MAPK7,NTRK2,PDK1,PDK2,PIK3CB,PIK3CG,PRKDC,SIK2,STK33,TEK,TGFBR1 | 25 | |||
| kinase-selectivity-class | ACVR2B,AXL,BRAF,CDK9,DYRK1B,EIF2AK3,GRK2,MAP2K6,MAPK7,PDK4,PRKDC,STK33,TGFBR1,TTK | 14 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 3.656 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 14.191 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 36.100 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 4.786 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 33.490 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 5.188 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 85.400 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 12.330 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 582.103 | uM | High | 1 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01MB05 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE QUINOLONE ANTIBACTERIALS Other quinolones |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000892 | Anti-Infective Agents, Urinary |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D059005 | Topoisomerase II Inhibitors |
| CHEBI has role | CHEBI:23924 | enzyme inhibitor |
| CHEBI has role | CHEBI:33281 | antimicrobial agent |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
| CHEBI has role | CHEBI:35441 | antiinfective agent |
| CHEBI has role | CHEBI:35718 | antifungal agent |
| CHEBI has role | CHEBI:36047 | antibacterial drug |
Related Drugs by ATC class:
J01MB Other quinolones 7 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.23 | acidic |
| pKa2 | 2.58 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| N0000166914 | NUI |
| D02301 | KEGG_DRUG |
| C0030031 | UMLSCUI |
| CHEBI:138856 | CHEBI |
| OXI | PDB_CHEM_ID |
| CHEMBL416755 | ChEMBL_ID |
| DB13627 | DRUGBANK_ID |
| D010093 | MESH_DESCRIPTOR_UI |
| 4628 | PUBCHEM_CID |
| 12999 | IUPHAR_LIGAND_ID |
| 1866 | INN_ID |
| L0A22B22FT | UNII |
| 7798 | RXNORM |
| 002871 | NDDF |
| 66653008 | SNOMEDCT_US |
| L0A22B22FT | INXIGHT DRUGS |
Pharmaceutical products:
None