nemonoxacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibacterials, nalidixic acid derivatives 5079 378746-64-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nemonoxacin
  • taigexyn
  • TG 873870
  • TG-873870
has antibacterial activity
  • Molecular weight: 371.44
  • Formula: C20H25N3O4
  • CLOGP: -0.01
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 96.10
  • ALOGS: -2.91
  • ROTB: 4

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 1.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.84 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 13.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01MB08 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
QUINOLONE ANTIBACTERIALS
Other quinolones

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Community acquired pneumonia indication 385093006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.37 acidic
pKa2 10.19 Basic
pKa3 5.04 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
CHEBI:136053 CHEBI
CHEMBL1213456 ChEMBL_ID
C543520 MESH_SUPPLEMENTAL_RECORD_UI
10836 IUPHAR_LIGAND_ID
8789 INN_ID
DB06600 DRUGBANK_ID
P94L0PVO94 UNII
11993740 PUBCHEM_CID
C2742587 UMLSCUI

Pharmaceutical products:

None