nemonoxacin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibacterials, nalidixic acid derivatives 5079 378746-64-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nemonoxacin
  • taigexyn
  • TG 873870
  • TG-873870
has antibacterial activity
  • Molecular weight: 371.44
  • Formula: C20H25N3O4
  • CLOGP: -0.28
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 96.10
  • ALOGS: -2.91
  • ROTB: 4

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 1.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.84 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 13.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01MB08 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
QUINOLONE ANTIBACTERIALS
Other quinolones

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Community acquired pneumonia indication 385093006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.37 acidic
pKa2 10.19 Basic
pKa3 5.04 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Streptococcus pneumoniae Bacteria MINIMUM INHIBITORY CONCENTRATION MIC90 6.79 SCIENTIFIC LITERATURE
Staphylococcus aureus subsp. aureus Bacteria MINIMUM INHIBITORY CONCENTRATION MIC90 7.09 SCIENTIFIC LITERATURE

External reference:

IDSource
C2742587 UMLSCUI
CHEBI:136053 CHEBI
CHEMBL1213456 ChEMBL_ID
DB06600 DRUGBANK_ID
C543520 MESH_SUPPLEMENTAL_RECORD_UI
10836 IUPHAR_LIGAND_ID
8789 INN_ID
P94L0PVO94 UNII
11993740 PUBCHEM_CID

Pharmaceutical products:

None