DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
piretanide ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
diuretics, piretanide derivatives
2201
55837-27-9
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
piretanide
arelix
diumax
eurelix
potent inhibitor of chloride transport; structure
Molecular weight: 362.40
Formula: C17H18N2O5S
CLOGP: 2.56
LIPINSKI: 0
HAC: 7
HDO: 2
TPSA: 109.93
ALOGS: -3.60
ROTB: 5
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
92 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance)
3.10 mL/min/kg
Lombardo F, Berellini G, Obach RS
t_half (Half-life)
1.30 hours
Lombardo F, Berellini G, Obach RS
MRTD (Maximum Recommended Therapeutic Daily Dose)
0.55 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)
0.17 L/kg
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.06 %
Lombardo F, Berellini G, Obach RS
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Approvals:
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Date
Agency
Company
Orphan
Jan. 1, 1980
YEAR INTRODUCED
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Stevens-Johnson syndrome
71.71
71.36
17
180
39149
79705042
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
C03CA03
CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Sulfonamides, plain
MeSH PA
D004232
Diuretics
MeSH PA
D049990
Membrane Transport Modulators
MeSH PA
D045283
Natriuretic Agents
MeSH PA
D049994
Sodium Potassium Chloride Symporter Inhibitors
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Hypertensive disorder
indication
38341003
DOID:10763
Edema
indication
267038008
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๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
4.58
acidic
pKa2
9.66
acidic
pKa3
3.92
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Solute carrier family 12 member 1
Transporter
Q13621
S12A1_HUMAN
INHIBITOR
Kd
8.30
WOMBAT-PK
KEGG DRUG
Solute carrier family 12 member 2
Transporter
P55011
S12A2_HUMAN
INHIBITOR
IC50
5.62
IUPHAR
KEGG DRUG
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External reference:
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ID
Source
004024
NDDF
151370
RXNORM
23252
MMSL
318031002
SNOMEDCT_US
3741
INN_ID
419451002
SNOMEDCT_US
4742
IUPHAR_LIGAND_ID
4849
PUBCHEM_CID
C0071132
UMLSCUI
C015451
MESH_SUPPLEMENTAL_RECORD_UI
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Pharmaceutical products:
None
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piretanide