furosemide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diuretics, furosemide derivatives 1258 54-31-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • frusemide
  • furosemide
  • furosemid
A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
  • Molecular weight: 330.74
  • Formula: C12H11ClN2O5S
  • CLOGP: 1.90
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 122.63
  • ALOGS: -3.45
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
40 mg O
40 mg P
40 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 66 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 25.92 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 71 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.12 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 1, 1966 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 2651.71 9.98 6335 448547 247533 52646651
Cardiac failure congestive 2374.44 9.98 3412 451470 89345 52804839
Drug ineffective 1615.44 9.98 2821 452061 814424 52079760
Cardiac failure 1557.90 9.98 2698 452184 83146 52811038
Rheumatoid arthritis 1379.65 9.98 481 454401 314050 52580134
Hyperkalaemia 1281.75 9.98 1923 452959 52333 52841851
Oedema peripheral 886.10 9.98 3332 451550 167455 52726729
Hyponatraemia 859.34 9.98 2447 452435 106160 52788024
Pemphigus 837.56 9.98 9 454873 104022 52790162
Renal failure 763.82 9.98 2484 452398 115968 52778216
International normalised ratio increased 718.62 9.98 1385 453497 46376 52847808
Contraindicated product administered 679.09 9.98 161 454721 135468 52758716
Glossodynia 647.19 9.98 56 454826 100235 52793949
Hypotension 637.31 9.98 4023 450859 250053 52644131
Maternal exposure during pregnancy 634.78 9.98 266 454616 155373 52738811
Hand deformity 632.25 9.98 20 454862 84829 52809355
Dyspnoea 609.76 9.98 7645 447237 578587 52315597
Off label use 609.18 9.98 2032 452850 470180 52424004
Alopecia 601.54 9.98 668 454214 233915 52660269
Hypokalaemia 598.71 9.98 1998 452884 94519 52799665
Drug interaction 593.45 9.98 3542 451340 215787 52678397
Drug intolerance 588.86 9.98 531 454351 204962 52689222
Systemic lupus erythematosus 580.29 9.98 174 454708 125240 52768944
Atrial fibrillation 577.33 9.98 2177 452705 109475 52784709
Treatment failure 566.01 9.98 194 454688 128209 52765975
Drug hypersensitivity 559.72 9.98 873 454009 264369 52629815
Bradycardia 538.50 9.98 1577 453305 69479 52824705
Pulmonary hypertension 525.70 9.98 1052 453830 36218 52857966
Infusion related reaction 521.71 9.98 344 454538 155613 52738571
Arthropathy 519.61 9.98 279 454603 141174 52753010
Anaemia 515.57 9.98 4077 450805 272641 52621543
Oedema 483.30 9.98 1564 453318 72782 52821402
Therapeutic product effect decreased 480.64 9.98 235 454647 125420 52768764
Pain 478.33 9.98 3001 451881 585397 52308787
Fluid retention 477.76 9.98 1274 453608 53127 52841057
Right ventricular failure 429.21 9.98 619 454263 16224 52877960
Completed suicide 425.33 9.98 333 454549 137868 52756316
Renal impairment 410.35 9.98 1600 453282 81718 52812466
Arthralgia 407.30 9.98 2149 452733 437634 52456550
Pulmonary arterial hypertension 402.32 9.98 782 454100 26340 52867844
Abdominal discomfort 399.72 9.98 801 454081 220261 52673923
Melaena 396.23 9.98 810 454072 28319 52865865
Gastrointestinal haemorrhage 391.04 9.98 1537 453345 78793 52815391
Joint swelling 388.67 9.98 893 453989 233745 52660439
Hypersensitivity 382.00 9.98 762 454120 209903 52684281
Rash 370.60 9.98 2259 452623 443932 52450252
Blood creatinine increased 352.94 9.98 1519 453363 81143 52813041
Synovitis 352.63 9.98 244 454638 107649 52786535
Pericarditis 345.71 9.98 65 454817 64341 52829843
Dehydration 338.54 9.98 2527 452355 165883 52728301
Myocardial infarction 337.62 9.98 1708 453174 97646 52796538
Fall 332.30 9.98 4582 450300 353858 52540326
Rheumatoid factor positive 325.15 9.98 5 454877 41193 52852991
Pulmonary oedema 305.67 9.98 1081 453801 52642 52841542
Discomfort 301.39 9.98 224 454658 95248 52798936
Exposure during pregnancy 297.81 9.98 376 454506 124484 52769700
Product use issue 294.42 9.98 459 454423 139125 52755059
Musculoskeletal stiffness 290.62 9.98 375 454507 122993 52771191
Lactic acidosis 289.01 9.98 834 454048 36419 52857765
Blood urea increased 286.78 9.98 668 454214 25563 52868621
Abortion spontaneous 282.64 9.98 33 454849 46602 52847582
Torsade de pointes 277.44 9.98 440 454442 12565 52881619
Injection site pain 277.21 9.98 335 454547 113056 52781128
Syncope 274.24 9.98 1764 453118 110229 52783955
Wound 268.70 9.98 231 454651 91326 52802858
Injection site erythema 260.04 9.98 169 454713 77080 52817104
Orthostatic hypotension 257.31 9.98 693 454189 29060 52865124
Hepatic enzyme increased 252.06 9.98 430 454452 125765 52768419
Fatigue 249.78 9.98 4560 450322 725946 52168238
Hypoglycaemia 247.66 9.98 1079 453803 57934 52836250
Duodenal ulcer perforation 246.28 9.98 13 454869 35170 52859014
Sinusitis 245.25 9.98 685 454197 167879 52726305
Ascites 242.08 9.98 818 454064 38917 52855267
Pleural effusion 234.79 9.98 1424 453458 87155 52807029
Injection site reaction 224.13 9.98 78 454804 51088 52843096
Helicobacter infection 221.63 9.98 34 454848 39035 52855149
Fluid overload 216.76 9.98 624 454258 27207 52866977
Therapeutic product effect incomplete 208.97 9.98 286 454596 91498 52802686
Metabolic alkalosis 203.67 9.98 184 454698 2835 52891349
Folliculitis 200.99 9.98 19 454863 31690 52862494
Device expulsion 199.68 9.98 14 454868 29799 52864385
Cardioactive drug level increased 197.73 9.98 156 454726 1973 52892211
Chronic kidney disease 197.48 9.98 813 454069 42557 52851627
Muscle injury 185.61 9.98 19 454863 29747 52864437
Rhabdomyolysis 176.62 9.98 793 454089 43130 52851054
Sleep disorder due to general medical condition, insomnia type 173.61 9.98 8 454874 24341 52869843
Cardiac failure chronic 172.73 9.98 192 454690 3838 52890346
Nasopharyngitis 171.67 9.98 950 453932 191345 52702839
Intentional overdose 171.25 9.98 192 454690 67013 52827171
Haematoma 165.72 9.98 649 454233 33195 52860989
Suicide attempt 165.53 9.98 151 454731 58017 52836167
Electrocardiogram QT prolonged 164.46 9.98 930 453952 55473 52838711
Psoriasis 163.73 9.98 308 454574 86781 52807403
Respiratory failure 163.11 9.98 1437 453445 99075 52795109
Gastrointestinal disorder 160.83 9.98 328 454554 89676 52804508
Injection site swelling 159.46 9.98 82 454800 42546 52851638
Swelling 157.31 9.98 969 453913 190136 52704048
Pneumonia 156.69 9.98 4561 450321 402608 52491576
Creatinine renal clearance decreased 155.37 9.98 305 454577 10346 52883838
Irritable bowel syndrome 154.39 9.98 90 454792 43542 52850642
Cardiac failure acute 153.31 9.98 277 454605 8815 52885369
Rectal haemorrhage 150.65 9.98 727 454155 40754 52853430
Psoriatic arthropathy 149.55 9.98 115 454767 48075 52846109
Injection site pruritus 148.28 9.98 85 454797 41504 52852680
Urine output decreased 147.27 9.98 314 454568 11309 52882875
Urticaria 146.93 9.98 627 454255 135258 52758926
Headache 146.49 9.98 3474 451408 533347 52360837
Hepatic encephalopathy 139.48 9.98 295 454587 10564 52883620
Hypoxia 138.62 9.98 881 454001 54799 52839385
Injection site bruising 138.47 9.98 74 454808 37572 52856612
Pregnancy 135.86 9.98 49 454833 31392 52862792
Dyspnoea exertional 134.93 9.98 867 454015 54133 52840051
Sopor 133.68 9.98 440 454442 20644 52873540
Haemoglobin decreased 131.92 9.98 1768 453114 135539 52758645
Generalised oedema 131.85 9.98 353 454529 14746 52879438
Chronic obstructive pulmonary disease 130.84 9.98 931 453951 60142 52834042
Ill-defined disorder 130.68 9.98 137 454745 49307 52844877
Coronary artery disease 126.49 9.98 593 454289 32844 52861340
Acute myocardial infarction 125.42 9.98 589 454293 32646 52861538
Multiple organ dysfunction syndrome 125.30 9.98 859 454023 54818 52839366
Ventricular tachycardia 124.78 9.98 384 454498 17378 52876806
Intentional product use issue 123.80 9.98 271 454611 72223 52821961
Transfusion 122.57 9.98 323 454559 13364 52880820
Cardiogenic shock 121.93 9.98 377 454505 17105 52877079
Anuria 120.10 9.98 302 454580 12138 52882046
Product use in unapproved indication 114.20 9.98 530 454352 111759 52782425
Shock haemorrhagic 113.95 9.98 246 454636 8937 52885247
Orthopnoea 110.70 9.98 192 454690 5912 52888272
Pseudo-Bartter syndrome 109.61 9.98 35 454847 32 52894152
Presyncope 109.13 9.98 478 454404 25716 52868468
Red blood cell sedimentation rate abnormal 106.14 9.98 7 454875 15682 52878502
Subdural haematoma 104.94 9.98 307 454575 13506 52880678
Mitral valve incompetence 103.18 9.98 384 454498 19167 52875017
Migraine 103.15 9.98 346 454536 80071 52814113
Epistaxis 103.10 9.98 966 453916 67744 52826440
Blood potassium decreased 102.44 9.98 643 454239 39817 52854367
Toxic epidermal necrolysis 102.13 9.98 435 454447 23115 52871069
Oliguria 100.67 9.98 235 454647 9003 52885181
Cardiac disorder 100.62 9.98 716 454166 46250 52847934
Stomatitis 100.58 9.98 462 454420 97696 52796488
Nausea 100.44 9.98 5350 449532 750741 52143443
Asthenia 99.56 9.98 3723 451159 339867 52554317
Lower respiratory tract infection 98.80 9.98 419 454463 90562 52803622
Hip arthroplasty 97.82 9.98 58 454824 27804 52866380
Loss of personal independence in daily activities 96.11 9.98 291 454591 69524 52824660
Nephrocalcinosis 95.36 9.98 75 454807 944 52893240
Cardiomegaly 95.10 9.98 351 454531 17449 52876735
Pericardial effusion 94.69 9.98 472 454410 26806 52867378
Drug abuse 94.66 9.98 267 454615 65259 52828925
Blood potassium increased 94.64 9.98 351 454531 17490 52876694
Acute respiratory failure 94.15 9.98 520 454362 30738 52863446
Hypovolaemia 93.68 9.98 246 454636 10156 52884028
Infection 93.57 9.98 977 453905 171228 52722956
Paraesthesia 92.60 9.98 671 454211 126844 52767340
Hypernatraemia 92.10 9.98 192 454690 6805 52887379
Hypocalcaemia 91.02 9.98 492 454390 28845 52865339
Sleep disorder 90.99 9.98 232 454650 58638 52835546
Rheumatic fever 90.32 9.98 4 454878 12600 52881584
Foetal exposure during pregnancy 89.71 9.98 98 454784 34617 52859567
Hypomagnesaemia 88.75 9.98 433 454449 24378 52869806
Multiple sclerosis relapse 88.42 9.98 154 454728 44699 52849485
Renal injury 85.93 9.98 231 454651 9673 52884511
Brain natriuretic peptide increased 85.54 9.98 152 454730 4773 52889411
Impaired healing 85.28 9.98 272 454610 63933 52830251
Bradyarrhythmia 85.27 9.98 96 454786 1947 52892237
Hepatic failure 85.09 9.98 560 454322 35246 52858938
Suicidal ideation 84.89 9.98 250 454632 60261 52833923
Death 84.88 9.98 3790 451092 353442 52540742
Depressed level of consciousness 83.55 9.98 769 454113 53659 52840525
Atrial flutter 83.51 9.98 224 454658 9367 52884817
Acute pulmonary oedema 83.49 9.98 204 454678 8051 52886133
Blood pressure decreased 83.12 9.98 850 454032 61019 52833165
Infective pulmonary exacerbation of cystic fibrosis 81.76 9.98 3 454879 11153 52883031
Febrile neutropenia 81.69 9.98 541 454341 104395 52789789
Confusional state 79.25 9.98 2193 452689 192028 52702156
No adverse event 78.14 9.98 134 454748 39131 52855053
Cerebrovascular accident 77.82 9.98 1295 453587 103879 52790305
Blood sodium decreased 77.44 9.98 396 454486 22720 52871464
Hyperuricaemia 76.04 9.98 150 454732 5106 52889078
Blood loss anaemia 75.75 9.98 205 454677 8618 52885566
Electrolyte imbalance 75.18 9.98 340 454542 18544 52875640
Haematemesis 74.79 9.98 485 454397 30372 52863812
Lower gastrointestinal haemorrhage 74.43 9.98 185 454697 7381 52886803
Gout 74.39 9.98 254 454628 12145 52882039
Accidental exposure to product 74.08 9.98 56 454826 23618 52870566
Depression 74.07 9.98 1106 453776 181946 52712238
C-reactive protein abnormal 73.77 9.98 67 454815 25803 52868381
Hypochloraemia 73.75 9.98 87 454795 1859 52892325
N-terminal prohormone brain natriuretic peptide increased 73.62 9.98 86 454796 1818 52892366
Ventricular fibrillation 72.16 9.98 245 454637 11680 52882504
Oxygen saturation decreased 71.59 9.98 983 453899 75742 52818442
Sedation complication 71.32 9.98 176 454706 6990 52887194
Atrioventricular block complete 70.60 9.98 188 454694 7827 52886357
Blood calcium decreased 69.76 9.98 344 454538 19450 52874734
Drug resistance 69.45 9.98 42 454840 19920 52874264
Cellulitis 69.05 9.98 969 453913 75020 52819164
Upper gastrointestinal haemorrhage 68.78 9.98 313 454569 17117 52877067
Atrioventricular block 68.57 9.98 173 454709 6967 52887217
Toxic skin eruption 68.44 9.98 257 454625 12882 52881302
Cardiomyopathy 68.28 9.98 308 454574 16780 52877404
Impaired work ability 67.98 9.98 18 454864 14072 52880112
Knee arthroplasty 67.31 9.98 114 454768 33455 52860729
Pulmonary arterial pressure increased 67.02 9.98 113 454769 3399 52890785
Inappropriate schedule of product administration 66.68 9.98 370 454512 74508 52819676
Left ventricular failure 66.33 9.98 143 454739 5190 52888994
Sepsis 65.34 9.98 1673 453209 144756 52749428
Red blood cell sedimentation rate increased 65.27 9.98 86 454796 27971 52866213
Acne 65.09 9.98 53 454829 21533 52872651
Hypoaesthesia 64.90 9.98 773 454109 132222 52761962
Colitis ulcerative 64.40 9.98 51 454831 21010 52873174
Haemodialysis 63.00 9.98 200 454682 9204 52884980
Hypovolaemic shock 62.77 9.98 144 454738 5453 52888731
Blood bilirubin increased 62.73 9.98 520 454362 35210 52858974
Insomnia 62.36 9.98 1171 453711 185901 52708283
Iron deficiency anaemia 61.33 9.98 317 454565 18263 52875921
Adverse drug reaction 61.31 9.98 242 454640 53383 52840801
Pruritus 61.13 9.98 1974 452908 291858 52602326
Anxiety 61.11 9.98 1246 453636 195458 52698726
Respiratory distress 60.83 9.98 495 454387 33332 52860852
Anaphylactic reaction 60.64 9.98 273 454609 58053 52836131
Wrong technique in product usage process 60.62 9.98 284 454598 59748 52834436
Asthma 60.48 9.98 615 454267 108357 52785827
Intentional self-injury 60.37 9.98 76 454806 25208 52868976
Cardiac arrest 60.24 9.98 1128 453754 92539 52801645
Pemphigoid 59.67 9.98 154 454728 6290 52887894
Night sweats 59.35 9.98 131 454751 34816 52859368
Oral herpes 59.03 9.98 56 454826 21123 52873061
Device difficult to use 58.78 9.98 9 454873 10350 52883834
Product quality issue 58.68 9.98 144 454738 36879 52857305
Intra-abdominal haematoma 58.42 9.98 72 454810 1613 52892571
Renal disorder 58.26 9.98 437 454445 28702 52865482
Chest pain 58.16 9.98 2074 452808 188111 52706073
Arrhythmia 58.15 9.98 523 454359 36256 52857928
Injection site warmth 57.75 9.98 24 454858 14104 52880080
Prerenal failure 56.94 9.98 70 454812 1564 52892620
Blood alkaline phosphatase increased 56.86 9.98 571 454311 40791 52853393
Cor pulmonale 56.43 9.98 77 454805 1913 52892271
Breast cancer 56.27 9.98 223 454659 49135 52845049
Prothrombin time prolonged 56.13 9.98 198 454684 9624 52884560
Injection site rash 56.13 9.98 36 454846 16543 52877641
Hepatic cirrhosis 55.74 9.98 302 454580 17720 52876464
Rheumatoid nodule 55.66 9.98 16 454866 11848 52882336
Ischaemic stroke 55.30 9.98 301 454581 17692 52876492
Glomerular filtration rate decreased 54.72 9.98 235 454647 12532 52881652
Ovarian cyst 54.72 9.98 31 454851 15238 52878946
Dialysis 54.46 9.98 203 454679 10139 52884045
Shock 54.43 9.98 361 454521 22778 52871406
Cardiac output decreased 54.43 9.98 54 454828 941 52893243
Haemoptysis 54.09 9.98 417 454465 27622 52866562
Muscle spasticity 53.54 9.98 44 454838 17794 52876390
Tricuspid valve incompetence 53.48 9.98 254 454628 14142 52880042
Aortic stenosis 52.95 9.98 119 454763 4444 52889740
Multiple sclerosis 52.81 9.98 94 454788 27059 52867125
Pyrexia 52.46 9.98 2857 452025 400336 52493848
Injection site urticaria 52.21 9.98 21 454861 12586 52881598
Sudden death 52.18 9.98 199 454683 10049 52884135
Congestive hepatopathy 51.40 9.98 86 454796 2570 52891614
Oropharyngeal pain 51.37 9.98 444 454438 80824 52813360
Ischaemic cardiomyopathy 51.22 9.98 85 454797 2523 52891661
Muscle haemorrhage 51.11 9.98 99 454783 3324 52890860
Pulmonary congestion 50.82 9.98 272 454610 15884 52878300
Haematuria 50.82 9.98 415 454467 27974 52866210
Drug ineffective for unapproved indication 50.82 9.98 61 454821 20659 52873525
Psychotic disorder 50.58 9.98 81 454801 24304 52869880
Live birth 50.58 9.98 33 454849 15026 52879158
Gestational diabetes 50.46 9.98 5 454877 8034 52886150
Joint stiffness 50.22 9.98 115 454767 30168 52864016
Device issue 49.75 9.98 67 454815 21591 52872593
Neutropenia 49.52 9.98 1008 453874 158177 52736007
Azotaemia 49.39 9.98 115 454767 4398 52889786
Tenosynovitis 49.29 9.98 12 454870 9927 52884257
Cerebral haemorrhage 49.20 9.98 430 454452 29566 52864618
Abdominal wall haematoma 48.85 9.98 90 454792 2908 52891276
Mucosal inflammation 48.32 9.98 194 454688 42590 52851594
Uterine perforation 48.22 9.98 4 454878 7415 52886769
Congestive cardiomyopathy 48.15 9.98 138 454744 6000 52888184
Catheter management 46.95 9.98 86 454796 2766 52891418
Therapeutic response decreased 46.88 9.98 227 454655 47342 52846842
Coeliac disease 46.46 9.98 9 454873 8726 52885458
Musculoskeletal pain 45.70 9.98 415 454467 74785 52819399
Concomitant disease aggravated 45.58 9.98 171 454711 8567 52885617
Arteriosclerosis coronary artery 44.57 9.98 166 454716 8288 52885896
Ejection fraction decreased 44.50 9.98 306 454576 19542 52874642
Progressive multifocal leukoencephalopathy 44.37 9.98 24 454858 12105 52882079
Basal cell carcinoma 44.08 9.98 83 454799 23386 52870798
Dilatation ventricular 44.02 9.98 79 454803 2500 52891684
Nodal rhythm 43.83 9.98 64 454818 1696 52892488
Enthesopathy 43.77 9.98 3 454879 6508 52887676
Medication error 43.42 9.98 488 454394 35877 52858307
Cardiac pacemaker insertion 43.34 9.98 99 454783 3738 52890446
Pharyngitis 43.31 9.98 59 454823 18921 52875263
International normalised ratio abnormal 43.14 9.98 87 454795 3010 52891174
Influenza like illness 42.83 9.98 323 454559 60536 52833648
Oxygen consumption increased 42.78 9.98 97 454785 3644 52890540
Dystonia 41.78 9.98 30 454852 12991 52881193
Rales 41.61 9.98 193 454689 10639 52883545
Hepatic function abnormal 41.30 9.98 489 454393 36410 52857774
Gastrointestinal tract mucosal pigmentation 41.20 9.98 38 454844 602 52893582
Foot deformity 41.09 9.98 59 454823 18509 52875675
Blister 41.03 9.98 451 454431 78302 52815882
Tachyarrhythmia 40.91 9.98 110 454772 4606 52889578
Jugular vein distension 40.64 9.98 44 454838 853 52893331
Mood swings 40.26 9.98 54 454828 17432 52876752
Haematotoxicity 40.23 9.98 9 454873 7888 52886296
Metabolic acidosis 39.71 9.98 542 454340 41700 52852484
Coronary arterial stent insertion 39.55 9.98 80 454802 2774 52891410
International normalised ratio decreased 39.36 9.98 107 454775 4510 52889674
Sinus node dysfunction 39.13 9.98 103 454779 4258 52889926
Hyponatraemic syndrome 38.98 9.98 37 454845 609 52893575
Hypervolaemia 38.95 9.98 68 454814 2105 52892079
Peripartum cardiomyopathy 38.23 9.98 22 454860 157 52894027
Faeces discoloured 38.08 9.98 270 454612 17416 52876768
Bone erosion 38.05 9.98 24 454858 11128 52883056
Coagulopathy 38.02 9.98 293 454589 19405 52874779
Device dislocation 38.01 9.98 91 454791 23506 52870678
Balance disorder 37.95 9.98 854 454028 72353 52821831
Ear pain 37.81 9.98 128 454754 29545 52864639
Ecchymosis 37.77 9.98 191 454691 10908 52883276
Product dose omission issue 37.75 9.98 1296 453586 190324 52703860
Throat irritation 37.48 9.98 141 454741 31540 52862644
Maternal exposure before pregnancy 37.14 9.98 3 454879 5683 52888501
Renal tubular necrosis 37.12 9.98 194 454688 11225 52882959
Seizure 37.09 9.98 831 454051 128678 52765506
Aspartate aminotransferase increased 36.84 9.98 958 453924 83071 52811113
Pneumonia aspiration 36.83 9.98 451 454431 33850 52860334
Concomitant disease progression 36.66 9.98 67 454815 2151 52892033
Subcutaneous haematoma 36.61 9.98 57 454825 1601 52892583
Colitis microscopic 36.32 9.98 138 454744 6956 52887228
Stillbirth 36.16 9.98 7 454875 6790 52887394
Menstruation irregular 36.10 9.98 8 454874 7058 52887126
Therapeutic response shortened 35.90 9.98 8 454874 7031 52887153
Polyuria 35.76 9.98 148 454734 7763 52886421
Tendonitis 35.73 9.98 56 454826 16950 52877234
Immunodeficiency 35.72 9.98 45 454837 14922 52879262
Gravitational oedema 35.68 9.98 49 454833 1225 52892959
Myocardial ischaemia 35.60 9.98 209 454673 12635 52881549
Aortic valve incompetence 35.39 9.98 125 454757 6080 52888104
Loss of consciousness 35.24 9.98 1247 453635 112965 52781219
Head injury 35.20 9.98 356 454526 25477 52868707
Nephrotic syndrome 35.19 9.98 113 454769 5232 52888952
Immune reconstitution inflammatory syndrome 34.92 9.98 6 454876 6340 52887844
Sinus bradycardia 34.46 9.98 228 454654 14373 52879811
Inferior vena cava dilatation 34.38 9.98 15 454867 53 52894131
Eye pain 34.27 9.98 140 454742 30585 52863599
Grip strength decreased 34.01 9.98 30 454852 11719 52882465
Exercise tolerance decreased 34.01 9.98 111 454771 5184 52889000
Inflammation 33.98 9.98 317 454565 56819 52837365
Coronary artery bypass 33.79 9.98 69 454813 2409 52891775
Hypercapnia 33.75 9.98 107 454775 4920 52889264
Fear of injection 33.75 9.98 4 454878 5585 52888599
Bone density decreased 33.56 9.98 27 454855 11037 52883147
Injection site mass 33.49 9.98 54 454828 16160 52878024
Osteoporosis 33.44 9.98 245 454637 46215 52847969
Ankylosing spondylitis 32.89 9.98 14 454868 8111 52886073
Blood uric acid increased 32.74 9.98 96 454786 4228 52889956
Intestinal haemorrhage 32.67 9.98 83 454799 3357 52890827
Disability 32.60 9.98 35 454847 12463 52881721
Prothrombin time shortened 32.59 9.98 57 454825 1767 52892417
Dermatitis exfoliative 32.50 9.98 118 454764 5818 52888366
Microcytic anaemia 32.49 9.98 82 454800 3303 52890881
Ventricular arrhythmia 32.39 9.98 86 454796 3574 52890610
Packed red blood cell transfusion 32.02 9.98 63 454819 2140 52892044
Encephalopathy 31.68 9.98 465 454417 36343 52857841
Angina unstable 31.65 9.98 137 454745 7331 52886853
Hypoglycaemic coma 31.61 9.98 70 454812 2588 52891596
Acidosis 31.33 9.98 185 454697 11207 52882977
Pneumonia viral 31.32 9.98 132 454750 6980 52887204
Schizophrenia 31.29 9.98 25 454857 10254 52883930
Decreased appetite 31.26 9.98 2181 452701 212793 52681391
Myopathy 31.05 9.98 164 454718 9528 52884656
Dilatation atrial 30.99 9.98 61 454821 2073 52892111
Bundle branch block left 30.76 9.98 130 454752 6883 52887301
Device use error 30.70 9.98 5 454877 5494 52888690
Poor venous access 30.69 9.98 24 454858 9951 52884233
Chronic respiratory failure 30.64 9.98 55 454827 1741 52892443
Acute coronary syndrome 30.44 9.98 172 454710 10252 52883932
Neck pain 30.35 9.98 346 454536 59670 52834514
Irritability 30.33 9.98 148 454734 30805 52863379
Pelvic pain 30.24 9.98 36 454846 12237 52881947
Nodal arrhythmia 30.18 9.98 46 454836 1268 52892916
Septic shock 30.11 9.98 719 454163 61510 52832674
Diabetes mellitus inadequate control 29.96 9.98 217 454665 14093 52880091
Uveitis 29.93 9.98 23 454859 9621 52884563
Ventricular dysfunction 29.73 9.98 73 454809 2890 52891294
Alkalosis hypochloraemic 29.70 9.98 18 454864 143 52894041
Nasal congestion 29.65 9.98 628 454254 52659 52841525
Heavy menstrual bleeding 29.61 9.98 65 454817 17311 52876873
Acute generalised exanthematous pustulosis 29.60 9.98 169 454713 10112 52884072
Myoclonus 29.60 9.98 233 454649 15531 52878653
Scleroderma 29.60 9.98 103 454779 4972 52889212
Disorientation 29.59 9.98 486 454396 38873 52855311
Pregnancy with contraceptive device 29.47 9.98 3 454879 4718 52889466
Unevaluable event 29.40 9.98 589 454293 48909 52845275
Amenorrhoea 29.40 9.98 22 454860 9327 52884857
Left ventricular dysfunction 29.32 9.98 180 454702 11057 52883127
Drug tolerance decreased 29.28 9.98 13 454869 7345 52886839
Arthritis 29.19 9.98 546 454336 86752 52807432
Dry eye 28.99 9.98 168 454714 33476 52860708
Activated partial thromboplastin time prolonged 28.78 9.98 128 454754 6931 52887253
Blood parathyroid hormone decreased 28.77 9.98 9 454873 6309 52887875
Bradyphrenia 28.74 9.98 124 454758 6626 52887558
Neuropathy peripheral 28.72 9.98 665 454217 102522 52791662
Premature labour 28.64 9.98 38 454844 12324 52881860
Oxygen therapy 28.55 9.98 56 454826 1898 52892286
Cerebral haematoma 28.53 9.98 80 454802 3434 52890750
Soft tissue disorder 28.52 9.98 91 454791 4199 52889985
Tachypnoea 28.50 9.98 232 454650 15622 52878562
Right atrial dilatation 28.43 9.98 31 454851 606 52893578
Disease recurrence 28.32 9.98 88 454794 20858 52873326
Impaired quality of life 28.17 9.98 4 454878 4867 52889317
Central nervous system lesion 28.17 9.98 27 454855 10135 52884049
Platelet count decreased 28.05 9.98 1158 453724 106941 52787243
Pain in extremity 27.98 9.98 2072 452810 282978 52611206
Burning sensation 27.86 9.98 268 454614 47745 52846439
Product storage error 27.81 9.98 43 454839 13087 52881097
Oesophageal varices haemorrhage 27.56 9.98 43 454839 1210 52892974
Ear infection 27.05 9.98 121 454761 25779 52868405
Hypercreatininaemia 27.01 9.98 25 454857 398 52893786
Retroperitoneal haematoma 27 9.98 69 454813 2801 52891383
Cardio-respiratory arrest 26.96 9.98 674 454208 58084 52836100
Cholestasis 26.90 9.98 368 454514 28327 52865857
Paracentesis 26.88 9.98 37 454845 927 52893257
Lethargy 26.88 9.98 624 454258 53136 52841048
Blood albumin decreased 26.79 9.98 214 454668 14328 52879856
Haemorrhage subcutaneous 26.72 9.98 72 454810 3019 52891165
Complication of device insertion 26.64 9.98 9 454873 6008 52888176
Venous pressure jugular increased 26.59 9.98 30 454852 610 52893574
Renal artery stenosis 26.49 9.98 53 454829 1823 52892361
Catheter site infection 26.30 9.98 98 454784 4894 52889290
Atrioventricular block first degree 26.26 9.98 118 454764 6417 52887767
Electrocardiogram ST segment abnormal 26.19 9.98 38 454844 1001 52893183
Nephrogenic anaemia 26.07 9.98 54 454828 1905 52892279
Petechiae 26.05 9.98 202 454680 13403 52880781
Bursitis 26.02 9.98 101 454781 22391 52871793
Poisoning 26.00 9.98 49 454833 13801 52880383
Haemorrhage intracranial 25.99 9.98 199 454683 13153 52881031
Haemorrhage 25.97 9.98 663 454219 57324 52836860
Occult blood positive 25.82 9.98 79 454803 3563 52890621
Upper respiratory tract infection 25.71 9.98 424 454458 68673 52825511
Cyanosis 25.48 9.98 235 454647 16404 52877780
Abdominal cavity drainage 25.43 9.98 24 454858 392 52893792
Dermatitis bullous 25.38 9.98 137 454745 8026 52886158
Visual impairment 25.32 9.98 453 454429 72459 52821725
Incorrect route of product administration 25.21 9.98 82 454800 19162 52875022
Nodule 25.17 9.98 71 454811 17358 52876826
Haemarthrosis 25.15 9.98 73 454809 3197 52890987
Nightmare 25.13 9.98 73 454809 17678 52876506
Pre-eclampsia 25.13 9.98 22 454860 8625 52885559
Malignant neoplasm progression 25 9.98 444 454438 71097 52823087
Metastases to bone 24.88 9.98 83 454799 19245 52874939
Pallor 24.86 9.98 326 454556 24856 52869328
Cardiac valve disease 24.82 9.98 87 454795 4215 52889969
Hyperglycaemia 24.82 9.98 480 454402 39604 52854580
Bundle branch block right 24.77 9.98 98 454784 5035 52889149
Toxicity to various agents 24.73 9.98 1577 453305 218021 52676163
Catheter site erythema 24.50 9.98 85 454797 4097 52890087
Abdominal pain upper 24.49 9.98 1163 453719 165128 52729056
Ischaemic hepatitis 24.28 9.98 55 454827 2065 52892119
Basilar artery occlusion 24.26 9.98 15 454867 124 52894060
Tooth infection 24.25 9.98 54 454828 14309 52879875
Hyperglycaemic hyperosmolar nonketotic syndrome 24.25 9.98 29 454853 629 52893555
Hypercalciuria 24.22 9.98 18 454864 207 52893977
Hyperaesthesia 24.19 9.98 23 454859 8666 52885518
Blood creatinine abnormal 23.92 9.98 65 454817 2739 52891445
Gastritis erosive 23.88 9.98 103 454779 5503 52888681
Mental status changes 23.87 9.98 472 454410 39099 52855085
Blood chloride decreased 23.85 9.98 102 454780 5429 52888755
Panniculitis 23.79 9.98 19 454863 7795 52886389
Catheter placement 23.78 9.98 54 454828 2031 52892153
Catheter site pruritus 23.73 9.98 53 454829 1971 52892213
Aspiration pleural cavity 23.73 9.98 32 454850 786 52893398
Photophobia 23.65 9.98 66 454816 16192 52877992
Injection site haemorrhage 23.65 9.98 102 454780 21949 52872235
Extrasystoles 23.63 9.98 97 454785 5069 52889115
Drug withdrawal syndrome 23.58 9.98 141 454741 27881 52866303
Sinus arrest 23.57 9.98 50 454832 1794 52892390
Nephrolithiasis 23.55 9.98 200 454682 36547 52857637
Osteoarthritis 23.52 9.98 441 454441 70045 52824139
Caesarean section 23.25 9.98 73 454809 17247 52876937
Malignant melanoma 23.24 9.98 35 454847 10767 52883417
Serotonin syndrome 23.22 9.98 131 454751 26275 52867909
Cardiac operation 23.21 9.98 65 454817 2788 52891396
Vascular purpura 23.15 9.98 43 454839 1398 52892786
Atrial enlargement 23.12 9.98 20 454862 290 52893894
Walking distance test abnormal 23.11 9.98 26 454856 527 52893657
Adverse event 23.07 9.98 231 454651 40830 52853354
Drug level increased 23.01 9.98 271 454611 20150 52874034
Complication of device removal 22.91 9.98 4 454878 4178 52890006
Brain natriuretic peptide 22.78 9.98 10 454872 36 52894148
Bone pain 22.77 9.98 300 454582 50422 52843762
Crying 22.66 9.98 105 454777 22157 52872027
Anticoagulation drug level above therapeutic 22.64 9.98 40 454842 1250 52892934
Lymphocyte count decreased 22.64 9.98 143 454739 27909 52866275
Body temperature increased 22.64 9.98 175 454707 32624 52861560
Mitral valve stenosis 22.62 9.98 37 454845 1085 52893099
Ventricular hypertrophy 22.47 9.98 77 454805 3688 52890496
Depressed mood 22.45 9.98 204 454678 36760 52857424
Troponin increased 22.44 9.98 139 454743 8566 52885618
Jaundice 22.30 9.98 373 454509 29940 52864244
Suspected suicide 22.21 9.98 5 454877 4363 52889821
Haemorrhagic disorder 22.10 9.98 31 454851 791 52893393
Heparin-induced thrombocytopenia 22.07 9.98 87 454795 4462 52889722
Protein total decreased 22.00 9.98 104 454778 5779 52888405
Intentional product misuse 21.86 9.98 293 454589 49099 52845085
Pharyngitis streptococcal 21.84 9.98 27 454855 9028 52885156
Cholecystitis chronic 21.75 9.98 35 454847 10483 52883701
Haemorrhoidal haemorrhage 21.71 9.98 79 454803 3899 52890285
Lupus-like syndrome 21.67 9.98 28 454854 9184 52885000
Hypoxic-ischaemic encephalopathy 21.66 9.98 82 454800 4126 52890058
Ureteric rupture 21.62 9.98 7 454875 7 52894177
Catheterisation cardiac 21.59 9.98 82 454800 4132 52890052
Synovial cyst 21.59 9.98 24 454858 8412 52885772
Circulatory collapse 21.58 9.98 292 454590 22422 52871762
Haematoma muscle 21.57 9.98 28 454854 662 52893522
Back pain 21.51 9.98 1712 453170 232535 52661649
Pulmonary alveolar haemorrhage 21.50 9.98 85 454797 4365 52889819
Pericardial haemorrhage 21.49 9.98 44 454838 1539 52892645
Neutrophil count decreased 21.46 9.98 292 454590 48806 52845378
Decubitus ulcer 21.33 9.98 158 454724 10335 52883849
Mydriasis 21.32 9.98 40 454842 11286 52882898
Mood altered 21.30 9.98 55 454827 13846 52880338
Anhedonia 21.20 9.98 160 454722 10527 52883657
Nephropathy 21.16 9.98 97 454785 5320 52888864
Foetal growth restriction 21.15 9.98 18 454864 7156 52887028
Hepatojugular reflux 21.15 9.98 7 454875 8 52894176
Crohn's disease 21.07 9.98 16 454866 6734 52887450
Temperature regulation disorder 21.02 9.98 5 454877 4202 52889982
Gouty arthritis 21.02 9.98 25 454857 539 52893645
Duodenal ulcer haemorrhage 20.96 9.98 57 454825 2403 52891781
Atrial septal defect repair 20.91 9.98 17 454865 225 52893959
Fungal infection 20.89 9.98 175 454707 32071 52862113
Right ventricular dysfunction 20.81 9.98 44 454838 1575 52892609
Liver function test abnormal 20.76 9.98 547 454335 47524 52846660
Lung transplant 20.76 9.98 65 454817 2969 52891215
Metabolic encephalopathy 20.75 9.98 102 454780 5759 52888425
Dyspnoea paroxysmal nocturnal 20.72 9.98 31 454851 840 52893344
Cardiac murmur 20.70 9.98 173 454709 11740 52882444
Cardiac cirrhosis 20.70 9.98 14 454868 137 52894047
Angina pectoris 20.60 9.98 352 454530 28373 52865811
Ovarian hyperstimulation syndrome 20.57 9.98 3 454879 3578 52890606
Adverse reaction 20.44 9.98 28 454854 8959 52885225
Liver function test increased 20.34 9.98 138 454744 26490 52867694
Ocular hyperaemia 20.32 9.98 106 454776 21685 52872499
Cardiac hypertrophy 20.30 9.98 34 454848 1017 52893167
Blood creatine increased 20.29 9.98 90 454792 4867 52889317
Vascular device infection 20.21 9.98 83 454799 4338 52889846
Tetany 20.21 9.98 47 454835 1796 52892388
Haematocrit decreased 20.14 9.98 438 454444 36893 52857291
Hot flush 20.07 9.98 282 454600 46878 52847306
Tuberculosis 20.06 9.98 40 454842 11031 52883153
Nephrosclerosis 20.02 9.98 33 454849 974 52893210
Type 2 diabetes mellitus 20.02 9.98 173 454709 31497 52862687
Musculoskeletal disorder 19.98 9.98 79 454803 17420 52876764
Ulcer 19.96 9.98 99 454783 20520 52873664
Urosepsis 19.87 9.98 223 454659 16387 52877797
Carbon dioxide increased 19.79 9.98 37 454845 1209 52892975
Right ventricular enlargement 19.73 9.98 18 454864 281 52893903
Fear 19.72 9.98 223 454659 16418 52877766
Abortion induced 19.71 9.98 39 454843 10787 52883397
Hepatotoxicity 19.59 9.98 148 454734 27732 52866452
Catheter site discharge 19.55 9.98 49 454833 1965 52892219
Galactorrhoea 19.47 9.98 5 454877 3990 52890194
Hypochromic anaemia 19.44 9.98 47 454835 1842 52892342
Limb reduction defect 19.42 9.98 20 454862 365 52893819
Pain in jaw 19.40 9.98 469 454413 40200 52853984
Eye irritation 19.38 9.98 86 454796 18363 52875821
Cardiac amyloidosis 19.31 9.98 27 454855 687 52893497
Skin turgor decreased 19.26 9.98 23 454859 498 52893686
Agranulocytosis 19.26 9.98 297 454585 23452 52870732
Blood urea abnormal 19.23 9.98 25 454857 592 52893592
Right ventricular dilatation 19.21 9.98 32 454850 953 52893231
Demyelination 19.14 9.98 15 454867 6212 52887972
Stress 19.09 9.98 357 454525 56727 52837457
Disturbance in attention 19.08 9.98 194 454688 34189 52859995
Peripheral swelling 19.07 9.98 2022 452860 204086 52690098
Internal haemorrhage 19.03 9.98 85 454797 4611 52889573
Catheter site haemorrhage 19.03 9.98 62 454820 2893 52891291
Device deployment issue 19.02 9.98 4 454878 3660 52890524
Anger 19.00 9.98 49 454833 12341 52881843
Hyperamylasaemia 19.00 9.98 20 454862 375 52893809
Pickwickian syndrome 18.97 9.98 19 454863 335 52893849
Emotional disorder 18.88 9.98 53 454829 12977 52881207
Lymphoedema 18.86 9.98 144 454738 9509 52884675
Volume blood decreased 18.84 9.98 14 454868 161 52894023
Wrong patient received product 18.83 9.98 50 454832 2078 52892106
Arteriosclerosis 18.74 9.98 149 454733 9962 52884222
Gouty tophus 18.69 9.98 14 454868 163 52894021
Injection site induration 18.68 9.98 28 454854 8630 52885554
Gastric haemorrhage 18.64 9.98 103 454779 6088 52888096
Sexual dysfunction 18.62 9.98 3 454879 3323 52890861
Erythromelalgia 18.58 9.98 13 454869 135 52894049
Atrial tachycardia 18.55 9.98 52 454830 2232 52891952
Hyperprolactinaemia 18.54 9.98 3 454879 3312 52890872
Continuous haemodiafiltration 18.48 9.98 33 454849 1040 52893144
Epilepsy 18.48 9.98 136 454746 25631 52868553
Sight disability 18.39 9.98 12 454870 110 52894074
Dyspnoea at rest 18.38 9.98 74 454808 3833 52890351
Middle insomnia 18.29 9.98 40 454842 10668 52883516
Catheter site pain 18.20 9.98 75 454807 3926 52890258
Ventricular extrasystoles 18.16 9.98 166 454716 11558 52882626
Blood pressure fluctuation 18.12 9.98 204 454678 35266 52858918
Joint range of motion decreased 18.09 9.98 85 454797 17871 52876313
Renal atrophy 18.09 9.98 38 454844 1354 52892830
Blood glucose decreased 18.07 9.98 255 454627 19761 52874423
Dysmenorrhoea 18.07 9.98 5 454877 3796 52890388
Tracheostomy 18.03 9.98 24 454858 582 52893602
Hospitalisation 18.02 9.98 759 454123 70253 52823931
Optic ischaemic neuropathy 17.98 9.98 33 454849 1063 52893121
Substance abuse 17.79 9.98 8 454874 4486 52889698
Blood pressure inadequately controlled 17.77 9.98 86 454796 4825 52889359
Cushingoid 17.76 9.98 21 454861 7161 52887023
Eosinophilia 17.76 9.98 268 454614 21067 52873117
Small for dates baby 17.71 9.98 5 454877 3747 52890437
Aortic valve stenosis 17.70 9.98 65 454817 3223 52890961
Product preparation error 17.66 9.98 8 454874 4467 52889717
Pulmonary hypoplasia 17.61 9.98 17 454865 286 52893898
Glomerulonephritis acute 17.61 9.98 9 454873 49 52894135
Rectosigmoid cancer 17.60 9.98 13 454869 148 52894036
Hypoalbuminaemia 17.53 9.98 156 454726 10780 52883404
Blood cholesterol increased 17.53 9.98 332 454550 52657 52841527
Therapy partial responder 17.52 9.98 16 454866 6147 52888037
Subdural haemorrhage 17.45 9.98 61 454821 2951 52891233
Diastolic dysfunction 17.44 9.98 97 454785 5747 52888437
Hepatitis fulminant 17.39 9.98 69 454813 3550 52890634
Carpal tunnel syndrome 17.38 9.98 85 454797 17682 52876502
Purging 17.32 9.98 9 454873 51 52894133
Therapeutic embolisation 17.31 9.98 13 454869 152 52894032
Feeling abnormal 17.29 9.98 960 453922 134341 52759843
Hypophagia 17.25 9.98 366 454516 30696 52863488
Gastric varices 17.17 9.98 13 454869 154 52894030
Gastrointestinal angiodysplasia 17.11 9.98 20 454862 423 52893761
Coagulation time prolonged 17.04 9.98 36 454846 1288 52892896
Asterixis 17.04 9.98 36 454846 1288 52892896
Genital haemorrhage 17.00 9.98 21 454861 7023 52887161
Skin weeping 16.99 9.98 18 454864 340 52893844
Affect lability 16.87 9.98 34 454848 9341 52884843
Scleritis 16.85 9.98 4 454878 3366 52890818
Cardioversion 16.81 9.98 34 454848 1179 52893005
Product complaint 16.74 9.98 169 454713 12088 52882096
Vital capacity decreased 16.69 9.98 31 454851 1008 52893176
Haemorrhagic diathesis 16.62 9.98 79 454803 4399 52889785
COVID-19 16.62 9.98 218 454664 36670 52857514
Tooth abscess 16.51 9.98 59 454823 13399 52880785
Pseudoporphyria 16.50 9.98 13 454869 164 52894020
Generalised tonic-clonic seizure 16.48 9.98 161 454721 28597 52865587
Nail disorder 16.44 9.98 37 454845 9768 52884416
Traumatic haematoma 16.32 9.98 38 454844 1453 52892731
Spontaneous haematoma 16.30 9.98 27 454855 800 52893384
Diabetic hyperosmolar coma 16.30 9.98 20 454862 446 52893738
Chills 16.29 9.98 729 454153 104119 52790065
Bleeding varicose vein 16.25 9.98 15 454867 238 52893946
Heart injury 16.20 9.98 33 454849 1150 52893034
Neutropenic sepsis 16.18 9.98 67 454815 14582 52879602
Drug reaction with eosinophilia and systemic symptoms 16.17 9.98 380 454502 32420 52861764
Intervertebral disc protrusion 16.14 9.98 115 454767 21830 52872354
Arteriospasm coronary 16.12 9.98 6 454876 3771 52890413
Spinal pain 16.12 9.98 48 454834 11532 52882652
Mucosal erosion 16.11 9.98 37 454845 1402 52892782
Hypocoagulable state 16.06 9.98 31 454851 1038 52893146
Hepatorenal syndrome 16.06 9.98 46 454836 1999 52892185
Throat tightness 16.06 9.98 117 454765 22099 52872085
Cardiopulmonary failure 16.04 9.98 69 454813 3682 52890502
Mitral valve disease 16.00 9.98 49 454833 2211 52891973
Hepatorenal failure 15.91 9.98 23 454859 604 52893580
Thermohypoaesthesia 15.90 9.98 11 454871 112 52894072
Fryns syndrome 15.90 9.98 9 454873 62 52894122
Surgery 15.88 9.98 185 454697 31779 52862405
Muscle twitching 15.83 9.98 79 454803 16347 52877837
Mixed liver injury 15.79 9.98 71 454811 3862 52890322
Nasal mucosal erosion 15.78 9.98 9 454873 63 52894121
Change of bowel habit 15.76 9.98 44 454838 1884 52892300
Haemophagocytic lymphohistiocytosis 15.72 9.98 34 454848 9103 52885081
Nephropathy toxic 15.71 9.98 126 454756 8446 52885738
Endocarditis 15.69 9.98 90 454792 5394 52888790
Pulmonary veno-occlusive disease 15.68 9.98 30 454852 998 52893186
Platelet transfusion 15.65 9.98 25 454857 718 52893466
Transplant evaluation 15.64 9.98 31 454851 1059 52893125
Staphylococcus test positive 15.62 9.98 70 454812 3803 52890381
Gastric disorder 15.60 9.98 173 454709 29992 52864192
Transient ischaemic attack 15.56 9.98 407 454475 35318 52858866
Optic neuritis 15.56 9.98 24 454858 7311 52886873
Cleft palate 15.55 9.98 30 454852 1004 52893180
Breast pain 15.54 9.98 29 454853 8200 52885984
Anal abscess 15.54 9.98 7 454875 3921 52890263
Peripheral sensory neuropathy 15.54 9.98 23 454859 7125 52887059
Erythema 15.53 9.98 1140 453742 155829 52738355
Malaise 15.53 9.98 3361 451521 354256 52539928
Drug monitoring procedure not performed 15.50 9.98 21 454861 518 52893666
Menstrual disorder 15.49 9.98 10 454872 4580 52889604
Mental disorder 15.47 9.98 133 454749 24243 52869941
Diabetic nephropathy 15.47 9.98 37 454845 1440 52892744
Cataract 15.47 9.98 314 454568 49306 52844878
Peripheral embolism 15.46 9.98 34 454848 1251 52892933
Paraesthesia oral 15.38 9.98 58 454824 12967 52881217
Disseminated intravascular coagulation 15.38 9.98 245 454637 19474 52874710
Acute motor-sensory axonal neuropathy 15.36 9.98 17 454865 338 52893846
Electrocardiogram QT shortened 15.35 9.98 11 454871 119 52894065
Deafness neurosensory 15.34 9.98 11 454871 4767 52889417
Bilirubin conjugated increased 15.33 9.98 55 454827 2696 52891488
Hypokalaemic syndrome 15.30 9.98 8 454874 46 52894138
Neuroleptic malignant syndrome 15.26 9.98 52 454830 11981 52882203
Vascular graft 15.26 9.98 26 454856 789 52893395
Hyperhidrosis 15.24 9.98 672 454210 96121 52798063
Urine odour abnormal 15.21 9.98 90 454792 5456 52888728
Low cardiac output syndrome 15.20 9.98 16 454866 300 52893884
Marasmus 15.11 9.98 21 454861 531 52893653
Transplant dysfunction 15.04 9.98 12 454870 4926 52889258
Mucosal dryness 15.04 9.98 53 454829 2575 52891609
Lymphorrhoea 15.03 9.98 8 454874 48 52894136
Hiatus hernia 15.02 9.98 243 454639 19377 52874807
Cardiac rehabilitation therapy 14.97 9.98 5 454877 6 52894178
Intestinal pseudo-obstruction 14.97 9.98 25 454857 746 52893438
Maternal exposure timing unspecified 14.92 9.98 4 454878 3102 52891082
Blood sodium increased 14.92 9.98 54 454828 2658 52891526
Product substitution issue 14.89 9.98 77 454805 15789 52878395
Platelet dysfunction 14.86 9.98 10 454872 97 52894087
Mouth ulceration 14.85 9.98 169 454713 29157 52865027
Device related infection 14.84 9.98 275 454607 22511 52871673
Disturbance in social behaviour 14.81 9.98 3 454879 2818 52891366
Blood potassium abnormal 14.80 9.98 50 454832 2377 52891807
Joint effusion 14.79 9.98 61 454821 13291 52880893
Staphylococcal sepsis 14.79 9.98 116 454766 7724 52886460
Product adhesion issue 14.78 9.98 15 454867 5482 52888702
Osteonecrosis of jaw 14.73 9.98 218 454664 35928 52858256
Device pacing issue 14.70 9.98 9 454873 73 52894111
Sedation 14.70 9.98 344 454538 29331 52864853
Paradoxical drug reaction 14.68 9.98 5 454877 3320 52890864
Influenza 14.64 9.98 664 454218 94715 52799469
Abdominal distension 14.61 9.98 826 454056 78964 52815220
Breast cancer metastatic 14.61 9.98 74 454808 15254 52878930
Electrocardiogram repolarisation abnormality 14.61 9.98 34 454848 1300 52892884
Brain natriuretic peptide abnormal 14.60 9.98 17 454865 358 52893826
Purpura 14.51 9.98 149 454733 10704 52883480
Blood pressure increased 14.42 9.98 1017 453865 139462 52754722
Mania 14.41 9.98 52 454830 11777 52882407
Clostridial sepsis 14.41 9.98 18 454864 409 52893775
Tubulointerstitial nephritis 14.40 9.98 209 454673 16295 52877889
Ammonia increased 14.39 9.98 77 454805 4496 52889688
Cerebral mass effect 14.39 9.98 27 454855 885 52893299
Femur fracture 14.36 9.98 244 454638 39341 52854843
End stage renal disease 14.35 9.98 96 454786 6075 52888109
Hyperaldosteronism 14.34 9.98 15 454867 279 52893905
Prothrombin level decreased 14.34 9.98 22 454860 610 52893574
Bundle branch block 14.32 9.98 27 454855 888 52893296
Illness 14.30 9.98 122 454760 22274 52871910
Puncture site haemorrhage 14.30 9.98 15 454867 280 52893904
Skin graft failure 14.28 9.98 10 454872 104 52894080
Heart valve incompetence 14.25 9.98 50 454832 2424 52891760
Polyarthritis 14.23 9.98 28 454854 7761 52886423
Pulmonary vein stenosis 14.21 9.98 9 454873 78 52894106
Neuralgia 14.20 9.98 130 454752 23391 52870793
Sputum culture positive 14.09 9.98 36 454846 1461 52892723
Hypertrophic cardiomyopathy 14.09 9.98 35 454847 1396 52892788
Catheter removal 14.06 9.98 17 454865 373 52893811
Respiratory acidosis 14.03 9.98 98 454784 6290 52887894
Angiopathy 14.02 9.98 75 454807 4379 52889805
Pericardial excision 14.01 9.98 6 454876 20 52894164
Antibiotic level above therapeutic 14.01 9.98 15 454867 287 52893897
Lymphadenopathy 13.97 9.98 221 454661 36034 52858150
Pulmonary arterial pressure abnormal 13.96 9.98 19 454863 471 52893713
Maternal drugs affecting foetus 13.95 9.98 16 454866 5530 52888654
Altered state of consciousness 13.91 9.98 293 454589 24543 52869641
Blood aldosterone increased 13.87 9.98 12 454870 174 52894010
Ulcer haemorrhage 13.87 9.98 65 454817 3599 52890585
Hepatic steatosis 13.82 9.98 150 454732 26109 52868075
Thalamic infarction 13.81 9.98 20 454862 526 52893658
Cardiothoracic ratio increased 13.79 9.98 5 454877 9 52894175
Metastases to liver 13.77 9.98 117 454765 21379 52872805
Infective exacerbation of chronic obstructive airways disease 13.75 9.98 33 454849 1287 52892897
Multiple drug therapy 13.74 9.98 35 454847 1418 52892766
Hypothermia 13.73 9.98 171 454711 12885 52881299
Heart transplant 13.72 9.98 18 454864 430 52893754
Stasis dermatitis 13.71 9.98 23 454859 689 52893495
Interstitial lung disease 13.64 9.98 621 454261 58001 52836183
Finger deformity 13.62 9.98 17 454865 5660 52888524
Second primary malignancy 13.59 9.98 25 454857 7107 52887077
Postpericardiotomy syndrome 13.58 9.98 6 454876 22 52894162
Frequent bowel movements 13.50 9.98 70 454812 14342 52879842
Procedural pain 13.49 9.98 72 454810 14645 52879539
International normalised ratio 13.48 9.98 9 454873 86 52894098
Sleep disorder due to a general medical condition 13.46 9.98 27 454855 7430 52886754
Rheumatic heart disease 13.46 9.98 5 454877 10 52894174
Pancytopenia 13.45 9.98 924 453958 90004 52804180
Superinfection 13.45 9.98 46 454836 2201 52891983
Myocardial necrosis 13.45 9.98 11 454871 147 52894037
Hepatic cytolysis 13.43 9.98 114 454768 7771 52886413
Peripheral arterial occlusive disease 13.42 9.98 68 454814 3886 52890298
Paranoia 13.41 9.98 51 454831 11373 52882811
Embolic stroke 13.37 9.98 66 454816 3733 52890451
Shunt occlusion 13.29 9.98 20 454862 545 52893639
Dermatitis allergic 13.22 9.98 65 454817 13503 52880681
Limb hypoplasia congenital 13.12 9.98 12 454870 188 52893996
Alkalosis 13.10 9.98 16 454866 355 52893829
Respiratory alkalosis 13.10 9.98 52 454830 2676 52891508
Vaginal haemorrhage 13.08 9.98 156 454726 26685 52867499
Pulmonary hypertensive crisis 13.07 9.98 12 454870 189 52893995
Inflammatory bowel disease 13.04 9.98 8 454874 3765 52890419
Food allergy 12.99 9.98 32 454850 8186 52885998
Pulmonary artery dilatation 12.99 9.98 13 454869 229 52893955
Retroperitoneal haemorrhage 12.97 9.98 54 454828 2840 52891344
Poisoning deliberate 12.95 9.98 35 454847 8678 52885506
Rash pruritic 12.89 9.98 326 454556 49684 52844500
Electrocardiogram ST-T segment depression 12.88 9.98 4 454878 3 52894181
Cognitive disorder 12.85 9.98 485 454397 44293 52849891
Hyperthyroidism 12.80 9.98 169 454713 12904 52881280
Blood iron decreased 12.79 9.98 160 454722 12068 52882116
Extradural haematoma 12.74 9.98 38 454844 1690 52892494
Mechanical ventilation 12.72 9.98 32 454850 1286 52892898
Ventricular septal defect 12.72 9.98 11 454871 4339 52889845
Premature rupture of membranes 12.70 9.98 14 454868 4926 52889258
Cystic fibrosis 12.69 9.98 9 454873 3922 52890262
Human herpesvirus 6 infection 12.65 9.98 3 454879 2527 52891657
Abdominal pain 12.63 9.98 1952 452930 253951 52640233
Lacrimation increased 12.60 9.98 95 454787 17808 52876376
Hypermagnesaemia 12.56 9.98 27 454855 978 52893206
Prothrombin time abnormal 12.53 9.98 17 454865 420 52893764
Urine sodium decreased 12.52 9.98 11 454871 163 52894021
Cyst 12.49 9.98 62 454820 12849 52881335
Ataxia 12.48 9.98 74 454808 14663 52879521
Haemoconcentration 12.47 9.98 8 454874 71 52894113
Supraventricular extrasystoles 12.45 9.98 72 454810 4328 52889856
Congenital nail disorder 12.44 9.98 9 454873 99 52894085
Multiple-drug resistance 12.43 9.98 6 454876 3229 52890955
Reversible airways obstruction 12.35 9.98 29 454853 1115 52893069
Cyanosis central 12.29 9.98 8 454874 73 52894111
Premature delivery 12.23 9.98 153 454729 25951 52868233
Systolic dysfunction 12.22 9.98 34 454848 1453 52892731
Pulmonary haemorrhage 12.22 9.98 101 454781 6832 52887352
Nephritis allergic 12.20 9.98 11 454871 169 52894015
Hypoproteinaemia 12.19 9.98 41 454841 1945 52892239
Dysaesthesia 12.17 9.98 10 454872 4045 52890139
Intermenstrual bleeding 12.15 9.98 36 454846 8662 52885522
Electrocardiogram U wave present 12.15 9.98 9 454873 103 52894081
Streptococcal sepsis 12.14 9.98 39 454843 1806 52892378
Sensitivity to weather change 12.08 9.98 21 454861 6101 52888083
Prothrombin consumption time prolonged 12.05 9.98 7 454875 51 52894133
Gamma-glutamyltransferase increased 12.04 9.98 373 454509 33182 52861002
Vaginal discharge 12.03 9.98 19 454863 5734 52888450
Aortic arteriosclerosis 11.99 9.98 89 454793 5825 52888359
Blood creatine phosphokinase increased 11.99 9.98 328 454554 28657 52865527
Localised oedema 11.99 9.98 82 454800 5227 52888957
Carbon dioxide abnormal 11.94 9.98 11 454871 174 52894010
Aortic valve calcification 11.92 9.98 16 454866 391 52893793
Electrocardiogram abnormal 11.91 9.98 114 454768 8039 52886145
Haemorrhagic stroke 11.87 9.98 87 454795 5671 52888513
Affective disorder 11.87 9.98 18 454864 5521 52888663
Urine chloride decreased 11.85 9.98 8 454874 78 52894106
White blood cell count decreased 11.84 9.98 907 453975 123568 52770616
Arteriovenous malformation 11.80 9.98 31 454851 1280 52892904
Gastric ulcer haemorrhage 11.78 9.98 79 454803 5003 52889181
Wound secretion 11.73 9.98 69 454813 4174 52890010
Normochromic normocytic anaemia 11.71 9.98 74 454808 4592 52889592
Gastrointestinal toxicity 11.70 9.98 14 454868 4748 52889436
Catheter site rash 11.70 9.98 23 454859 781 52893403
Cerebral infarction 11.69 9.98 282 454600 24162 52870022
Onychomycosis 11.68 9.98 16 454866 5120 52889064
Anal fistula 11.67 9.98 5 454877 2886 52891298
Post transplant lymphoproliferative disorder 11.67 9.98 12 454870 4359 52889825
Dry mouth 11.65 9.98 403 454479 59147 52835037
Hypoprothrombinaemia 11.59 9.98 14 454868 307 52893877
Fine motor skill dysfunction 11.59 9.98 11 454871 4148 52890036
Blood iron abnormal 11.57 9.98 7 454875 3320 52890864
Incorrect dose administered by device 11.56 9.98 8 454874 3531 52890653
Foot fracture 11.55 9.98 119 454763 20920 52873264
Mouth breathing 11.55 9.98 6 454876 34 52894150
Cardiac valve replacement complication 11.54 9.98 11 454871 182 52894002
Vaginal infection 11.54 9.98 24 454858 6517 52887667
Wound infection pseudomonas 11.52 9.98 33 454849 1434 52892750
Cerebral venous thrombosis 11.51 9.98 45 454837 2299 52891885
Lip erosion 11.51 9.98 25 454857 912 52893272
Biopsy liver 11.50 9.98 16 454866 405 52893779
Transcription medication error 11.50 9.98 13 454869 265 52893919
Aplastic anaemia 11.49 9.98 115 454767 8206 52885978
Base excess negative 11.48 9.98 4 454878 6 52894178
Peritoneal dialysis 11.48 9.98 15 454867 357 52893827
Troponin 11.48 9.98 4 454878 6 52894178
Small intestine gangrene 11.48 9.98 4 454878 6 52894178
Transplant rejection 11.48 9.98 46 454836 10105 52884079
Haemorrhagic transformation stroke 11.48 9.98 29 454853 1169 52893015
Thrombocytopenia 11.45 9.98 1351 453531 137376 52756808
Blood culture negative 11.45 9.98 10 454872 147 52894037
Fibromyalgia 11.44 9.98 287 454595 43788 52850396
Cervical dysplasia 11.41 9.98 6 454876 3075 52891109
Cardiovascular insufficiency 11.41 9.98 32 454850 1374 52892810
Ischaemia 11.40 9.98 74 454808 4634 52889550
Systemic scleroderma 11.36 9.98 25 454857 920 52893264
Brain compression 11.35 9.98 15 454867 361 52893823
Bipolar disorder 11.33 9.98 31 454851 7655 52886529
Mucormycosis 11.32 9.98 4 454878 2596 52891588
Oedema due to renal disease 11.32 9.98 3 454879 0 52894184
Rectosigmoid cancer metastatic 11.32 9.98 3 454879 0 52894184
Benign small intestinal neoplasm 11.32 9.98 3 454879 0 52894184
Tracheal operation 11.32 9.98 3 454879 0 52894184
Thyroid gland scan abnormal 11.32 9.98 3 454879 0 52894184
Ammonia decreased 11.32 9.98 3 454879 0 52894184
Urine chloride increased 11.32 9.98 3 454879 0 52894184
Mitral valve disease mixed 11.32 9.98 3 454879 0 52894184
Dependence on respirator 11.31 9.98 7 454875 58 52894126
Aortic valve replacement 11.30 9.98 21 454861 683 52893501
Autoimmune haemolytic anaemia 11.28 9.98 71 454811 4400 52889784
Body mass index decreased 11.27 9.98 16 454866 413 52893771
Congenital oral malformation 11.26 9.98 11 454871 188 52893996
Adrenal insufficiency 11.25 9.98 77 454805 14752 52879432
Amyloidosis 11.25 9.98 28 454854 1118 52893066
Blood glucose increased 11.24 9.98 785 454097 76576 52817608
Joint laxity 11.24 9.98 3 454879 2333 52891851
Fracture delayed union 11.22 9.98 3 454879 2330 52891854
Rectal ulcer haemorrhage 11.21 9.98 11 454871 189 52893995
Chronic left ventricular failure 11.21 9.98 14 454868 318 52893866
Drug therapeutic incompatibility 11.21 9.98 7 454875 59 52894125
Cardiac resynchronisation therapy 11.18 9.98 5 454877 19 52894165
Supraventricular tachycardia 11.18 9.98 178 454704 14147 52880037
Right atrial pressure increased 11.18 9.98 10 454872 152 52894032
Urinary tract discomfort 11.17 9.98 11 454871 190 52893994
Feeling jittery 11.14 9.98 59 454823 12024 52882160
Bone marrow failure 11.13 9.98 185 454697 29930 52864254
Muscle rigidity 11.11 9.98 51 454831 10790 52883394
Infected skin ulcer 11.07 9.98 44 454838 2265 52891919
Deformity 11.05 9.98 33 454849 7921 52886263
Haemodynamic instability 11.03 9.98 117 454765 8477 52885707
Urinary tract infection 11.02 9.98 2261 452621 237642 52656542
Cardiorenal syndrome 11.01 9.98 20 454862 639 52893545
Blood prolactin increased 11.01 9.98 7 454875 3232 52890952
Leukaemic infiltration renal 10.99 9.98 5 454877 20 52894164
Asphyxia 10.96 9.98 87 454795 5814 52888370
Craniocerebral injury 10.95 9.98 45 454837 2353 52891831
Cytomegalovirus infection reactivation 10.93 9.98 4 454878 2540 52891644
Long QT syndrome congenital 10.88 9.98 6 454876 39 52894145
Infection susceptibility increased 10.88 9.98 4 454878 2533 52891651
Hypersensitivity vasculitis 10.86 9.98 70 454812 4373 52889811
Injury associated with device 10.86 9.98 7 454875 3208 52890976
Atrioventricular block second degree 10.85 9.98 64 454818 3875 52890309
Dermatitis atopic 10.85 9.98 10 454872 3824 52890360
Ventricular enlargement 10.83 9.98 7 454875 63 52894121
Left ventricular hypertrophy 10.82 9.98 79 454803 5144 52889040
Pathogen resistance 10.80 9.98 25 454857 6535 52887649
Drug specific antibody present 10.80 9.98 8 454874 3410 52890774
Patent ductus arteriosus repair 10.80 9.98 5 454877 21 52894163
Injection site discolouration 10.78 9.98 29 454853 7201 52886983
Anaphylactic shock 10.76 9.98 127 454755 21766 52872418
Dysgeusia 10.76 9.98 281 454601 42650 52851534
Hypertensive heart disease 10.75 9.98 47 454835 2526 52891658
Cystitis klebsiella 10.72 9.98 11 454871 200 52893984
Blood pH increased 10.69 9.98 18 454864 541 52893643
Amnesia 10.68 9.98 299 454583 44989 52849195
Large intestinal polypectomy 10.67 9.98 11 454871 201 52893983
Central venous catheterisation 10.64 9.98 41 454841 2080 52892104
Tuberculin test positive 10.64 9.98 7 454875 3173 52891011
Endometriosis 10.57 9.98 13 454869 4356 52889828
Cytomegalovirus infection 10.53 9.98 111 454771 19428 52874756
Bone density abnormal 10.52 9.98 7 454875 3155 52891029
Acute respiratory distress syndrome 10.51 9.98 267 454615 23065 52871119
Escherichia sepsis 10.49 9.98 71 454811 4510 52889674
Premature baby 10.47 9.98 113 454769 19688 52874496
Device malfunction 10.46 9.98 86 454796 15822 52878362
Heparin-induced thrombocytopenia test 10.46 9.98 4 454878 9 52894175
PO2 abnormal 10.46 9.98 4 454878 9 52894175
Tongue disorder 10.44 9.98 40 454842 8901 52885283
Product physical issue 10.43 9.98 18 454864 5244 52888940
Right atrial enlargement 10.42 9.98 8 454874 97 52894087
Laryngitis 10.41 9.98 51 454831 10604 52883580
Sickle cell anaemia with crisis 10.40 9.98 14 454868 4513 52889671
Arterial haemorrhage 10.32 9.98 36 454846 1740 52892444
Muscle spasms 10.32 9.98 999 453883 133796 52760388
QRS axis abnormal 10.31 9.98 26 454856 1047 52893137
Vitamin B1 decreased 10.29 9.98 6 454876 44 52894140
Acute graft versus host disease 10.28 9.98 13 454869 4304 52889880
Blood pressure systolic decreased 10.28 9.98 86 454796 5838 52888346
Acute cutaneous lupus erythematosus 10.26 9.98 12 454870 254 52893930
Withdrawal syndrome 10.26 9.98 110 454772 19191 52874993
Coronary artery occlusion 10.25 9.98 112 454770 8175 52886009
Craniotomy 10.25 9.98 11 454871 211 52893973
Congenital diaphragmatic hernia 10.25 9.98 11 454871 211 52893973
Intraocular pressure increased 10.23 9.98 25 454857 6413 52887771
Anaemia of chronic disease 10.23 9.98 39 454843 1969 52892215
Sciatica 10.22 9.98 127 454755 21566 52872618
Peripheral venous disease 10.18 9.98 76 454806 4984 52889200
Rhinorrhoea 10.16 9.98 364 454518 53214 52840970
Hypochromasia 10.15 9.98 13 454869 303 52893881
Palpitations 10.15 9.98 1009 453873 101339 52792845
Ammonia abnormal 10.15 9.98 8 454874 101 52894083
Diagnostic procedure 10.15 9.98 8 454874 101 52894083
Epstein-Barr virus infection 10.15 9.98 31 454851 7387 52886797
Colitis 10.14 9.98 273 454609 41279 52852905
Viral sepsis 10.12 9.98 5 454877 25 52894159
Bronchial secretion retention 10.12 9.98 34 454848 1612 52892572
Acid base balance abnormal 10.08 9.98 12 454870 259 52893925
Neurotoxicity 10.08 9.98 83 454799 15266 52878918
Clostridium difficile colitis 10.06 9.98 230 454652 19535 52874649
Joint destruction 10.05 9.98 9 454873 3490 52890694
Electrocardiogram T wave peaked 10.05 9.98 11 454871 216 52893968
Tumour lysis syndrome 10.01 9.98 107 454775 7767 52886417

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure congestive 1883.77 11.76 3334 349662 81518 32079012
Acute kidney injury 1633.70 11.76 6895 346101 286573 31873957
Cardiac failure 1408.77 11.76 3087 349909 88586 32071944
Hyperkalaemia 874.60 11.76 2170 350826 67580 32092950
Drug ineffective 773.89 11.76 1908 351088 381569 31778961
Oedema peripheral 552.09 11.76 2577 350419 111514 32049016
Renal failure 458.03 11.76 2757 350239 131721 32028809
International normalised ratio increased 429.31 11.76 1339 351657 47696 32112834
Drug abuse 422.46 11.76 171 352825 80072 32080458
Hypotension 418.76 11.76 3875 349121 212235 31948295
Off label use 386.15 11.76 1863 351133 304457 31856073
Completed suicide 371.37 11.76 277 352719 92240 32068290
Dyspnoea 354.73 11.76 5703 347293 356342 31804188
Oedema 313.83 11.76 1141 351855 44006 32116524
Toxicity to various agents 305.96 11.76 955 352041 177086 31983444
Fluid retention 294.08 11.76 789 352207 25761 32134769
Cardiac failure chronic 284.99 11.76 372 352624 6868 32153662
Blood creatinine increased 284.21 11.76 1902 351094 94230 32066300
Atrial fibrillation 280.52 11.76 2197 350799 114507 32046023
Blood urea increased 263.85 11.76 861 352135 31412 32129118
Hypokalaemia 253.29 11.76 1227 351769 53867 32106663
Renal impairment 251.30 11.76 1785 351211 90187 32070343
Rheumatoid arthritis 219.98 11.76 104 352892 44440 32116090
Pulmonary hypertension 219.89 11.76 602 352394 19892 32140638
Ascites 215.80 11.76 937 352059 39254 32121276
Hepatic encephalopathy 208.45 11.76 484 352512 14411 32146119
Headache 201.26 11.76 1276 351720 194921 31965609
Chronic kidney disease 189.26 11.76 898 352098 39077 32121453
Hyponatraemia 181.18 11.76 1407 351589 73106 32087424
Foetal exposure during pregnancy 179.81 11.76 113 352883 41188 32119342
Melaena 175.36 11.76 794 352202 33871 32126659
Suicide attempt 174.42 11.76 99 352897 38145 32122385
Suicidal ideation 171.66 11.76 100 352896 37983 32122547
Anaemia 168.82 11.76 3384 349612 220240 31940290
Dehydration 167.53 11.76 2137 350859 126821 32033709
Bradycardia 167.23 11.76 1339 351657 70223 32090307
Intentional overdose 163.68 11.76 127 352869 41474 32119056
Pulmonary oedema 163.11 11.76 958 352038 45309 32115221
Treatment failure 162.59 11.76 113 352883 39050 32121480
Arthralgia 161.23 11.76 948 352048 147500 32013030
Ventricular tachycardia 156.13 11.76 620 352376 24936 32135594
Pleural effusion 155.63 11.76 1423 351573 77569 32082961
Product use in unapproved indication 152.90 11.76 463 352533 86741 32073789
Gastrointestinal haemorrhage 152.32 11.76 1527 351469 85355 32075175
Therapeutic product effect incomplete 149.40 11.76 137 352859 41204 32119326
Febrile neutropenia 138.75 11.76 747 352249 118819 32041711
Fall 136.47 11.76 2934 350062 193267 31967263
Syncope 135.57 11.76 1536 351460 88588 32071942
Pyrexia 132.06 11.76 2565 350431 317403 31843127
Myocardial infarction 127.14 11.76 1993 351003 123683 32036847
Right ventricular failure 125.05 11.76 281 352715 8182 32152348
Hypoglycaemia 124.53 11.76 1013 351983 53369 32107161
Neutropenia 124.36 11.76 968 352028 141207 32019323
Lactic acidosis 123.13 11.76 702 352294 32834 32127696
Drug dependence 121.95 11.76 51 352945 23433 32137097
Intentional product misuse 119.32 11.76 129 352867 35922 32124608
Injection site pain 118.91 11.76 110 352886 32948 32127582
Orthostatic hypotension 116.89 11.76 570 352426 25080 32135450
Orthopnoea 115.21 11.76 202 352794 4885 32155645
Cardiac failure acute 114.09 11.76 304 352692 9880 32150650
Generalised oedema 111.08 11.76 343 352653 12140 32148390
Hypovolaemia 107.67 11.76 273 352723 8604 32151926
Ejection fraction decreased 106.73 11.76 427 352569 17231 32143299
Fluid overload 105.69 11.76 458 352538 19163 32141367
Depression 105.18 11.76 620 352376 96440 32064090
Blood potassium increased 102.89 11.76 408 352588 16396 32144134
Rectal haemorrhage 101.86 11.76 726 352270 36697 32123833
Coronary artery disease 101.19 11.76 902 352094 48804 32111726
Seizure 100.93 11.76 686 352310 103168 32057362
Pulmonary arterial hypertension 100.89 11.76 284 352712 9537 32150993
Dyspnoea exertional 100.40 11.76 746 352250 38215 32122315
Chronic obstructive pulmonary disease 97.85 11.76 882 352114 47871 32112659
Drug hypersensitivity 97.53 11.76 437 352559 72963 32087567
Intentional product use issue 96.76 11.76 195 352801 42016 32118514
Mitral valve incompetence 96.70 11.76 368 352628 14503 32146027
Product dose omission issue 92.64 11.76 692 352304 101883 32058647
Brain natriuretic peptide increased 92.56 11.76 167 352829 4133 32156397
Nausea 92.12 11.76 2717 350279 318132 31842398
Shock haemorrhagic 91.49 11.76 289 352707 10356 32150174
Rash 90.49 11.76 1664 351332 207669 31952861
Urticaria 90.43 11.76 337 352659 59277 32101253
Aggression 88.55 11.76 184 352812 39205 32121325
Psychotic disorder 88.37 11.76 72 352924 22948 32137582
Infusion related reaction 85.81 11.76 234 352762 45365 32115165
Insomnia 84.08 11.76 691 352305 99657 32060873
N-terminal prohormone brain natriuretic peptide increased 84.03 11.76 107 352889 1925 32158605
Drug interaction 81.66 11.76 3015 349981 215170 31945360
Gravitational oedema 80.65 11.76 62 352934 578 32159952
Drug withdrawal syndrome 80.53 11.76 61 352935 20170 32140360
Therapeutic product effect decreased 80.25 11.76 133 352863 30884 32129646
Metabolic alkalosis 79.00 11.76 88 352908 1366 32159164
Immune reconstitution inflammatory syndrome 77.92 11.76 7 352989 9552 32150978
Pain 77.89 11.76 1501 351495 186055 31974475
Acute pulmonary oedema 77.71 11.76 222 352774 7519 32153011
Psoriasis 75.80 11.76 252 352744 45871 32114659
Mucosal inflammation 75.31 11.76 156 352840 33278 32127252
Tricuspid valve incompetence 75.16 11.76 247 352749 9040 32151490
Respiratory failure 75.03 11.76 1605 351391 105577 32054953
Nasopharyngitis 74.76 11.76 397 352599 63390 32097140
Sinusitis 74.65 11.76 180 352816 36380 32124150
Hepatic failure 73.38 11.76 649 352347 35031 32125499
Colitis ulcerative 72.36 11.76 48 352948 17003 32143527
Psoriatic arthropathy 72.19 11.76 53 352943 17807 32142723
Gout 72.02 11.76 397 352599 18331 32142199
Musculoskeletal stiffness 72.01 11.76 204 352792 39060 32121470
Ischaemic cardiomyopathy 71.00 11.76 191 352805 6243 32154287
Cardiogenic shock 70.95 11.76 425 352571 20237 32140293
Drug intolerance 70.43 11.76 293 352703 49942 32110588
Product use issue 69.62 11.76 315 352681 52462 32108068
Asthma 69.53 11.76 245 352751 43820 32116710
Urine output decreased 68.49 11.76 259 352737 10175 32150355
Hypernatraemia 67.56 11.76 220 352776 8013 32152517
Infective pulmonary exacerbation of cystic fibrosis 67.50 11.76 8 352988 8771 32151759
Hypersensitivity 67.39 11.76 360 352636 57398 32103132
Colitis 67.09 11.76 170 352826 33781 32126749
Anuria 66.24 11.76 263 352733 10574 32149956
Renal injury 66.15 11.76 283 352713 11772 32148758
Fatigue 66.06 11.76 3124 349872 347577 31812953
Left ventricular failure 65.79 11.76 162 352834 5011 32155519
Overdose 65.25 11.76 617 352379 86460 32074070
Exposure during pregnancy 64.91 11.76 11 352985 9218 32151312
Multiple sclerosis relapse 63.76 11.76 24 352972 11757 32148773
Blood pressure decreased 63.05 11.76 839 352157 50241 32110289
Synovitis 62.60 11.76 20 352976 10858 32149672
Coronary artery bypass 62.49 11.76 157 352839 4919 32155611
Venous pressure jugular increased 62.48 11.76 59 352937 745 32159785
Schizophrenia 61.80 11.76 16 352980 9968 32150562
Cardiomegaly 61.69 11.76 325 352671 14746 32145784
Irritability 60.78 11.76 109 352887 24545 32135985
Sedation 59.42 11.76 68 352928 18458 32142072
Jugular vein distension 59.15 11.76 50 352946 540 32159990
Left ventricular dysfunction 59.03 11.76 235 352761 9460 32151070
Haematoma 57.44 11.76 476 352520 25208 32135322
Acute myocardial infarction 56.96 11.76 878 352118 54271 32106259
Hepatic cirrhosis 56.60 11.76 344 352652 16465 32144065
Asthenia 56.12 11.76 3114 349882 232830 31927700
Congestive cardiomyopathy 56.02 11.76 189 352807 7013 32153517
Anaphylactic reaction 55.89 11.76 156 352840 30016 32130514
Accidental exposure to product 55.52 11.76 26 352970 11176 32149354
Cardiomyopathy 54.74 11.76 329 352667 15684 32144846
Serotonin syndrome 54.22 11.76 77 352919 19040 32141490
Loss of personal independence in daily activities 54.08 11.76 133 352863 26700 32133830
Intentional self-injury 53.94 11.76 43 352953 13857 32146673
Pathogen resistance 53.82 11.76 18 352978 9492 32151038
Pemphigoid 53.40 11.76 207 352789 8229 32152301
Rales 53.17 11.76 196 352800 7605 32152925
Abnormal behaviour 52.70 11.76 132 352864 26334 32134196
Akathisia 52.56 11.76 7 352989 7018 32153512
Rhabdomyolysis 52.56 11.76 1024 351972 66241 32094289
Cardioactive drug level increased 52.38 11.76 79 352917 1677 32158853
Poisoning 52.14 11.76 28 352968 11130 32149400
Myocardial ischaemia 52.13 11.76 351 352645 17408 32143122
Injury 51.76 11.76 416 352580 21829 32138701
Vomiting 51.56 11.76 2063 350933 233494 31927036
Concomitant disease progression 51.56 11.76 97 352899 2481 32158049
Cytomegalovirus infection 51.48 11.76 126 352870 25338 32135192
Vitamin B1 deficiency 51.43 11.76 33 352963 223 32160307
Peripheral swelling 49.92 11.76 1030 351966 67315 32093215
Neuropathy peripheral 49.67 11.76 565 352431 76417 32084113
Aortic stenosis 49.62 11.76 129 352867 4129 32156401
Drug ineffective for unapproved indication 49.19 11.76 47 352949 13865 32146665
Injection site erythema 49.07 11.76 52 352944 14616 32145914
Erectile dysfunction 48.64 11.76 88 352908 19751 32140779
Injection site reaction 48.51 11.76 33 352963 11536 32148994
Infection 48.50 11.76 638 352358 84077 32076453
Azotaemia 47.19 11.76 147 352849 5227 32155303
Joint swelling 47.15 11.76 348 352648 51387 32109143
Appendicitis 47.06 11.76 19 352977 8918 32151612
Stomatitis 46.77 11.76 251 352745 39978 32120552
Torsade de pointes 46.16 11.76 181 352815 7234 32153296
Haematotoxicity 45.66 11.76 9 352987 6767 32153763
Drug resistance 45.36 11.76 115 352881 22850 32137680
Malignant neoplasm progression 45.36 11.76 590 352406 77906 32082624
Fear 44.90 11.76 242 352754 11077 32149453
Cardiac disorder 44.56 11.76 670 352326 41196 32119334
Sopor 44.46 11.76 248 352748 11501 32149029
Agitation 43.96 11.76 403 352593 56833 32103697
Haemoglobin decreased 43.75 11.76 1650 351346 118021 32042509
Glomerular filtration rate decreased 43.02 11.76 262 352734 12549 32147981
Substance abuse 42.83 11.76 12 352984 7095 32153435
Paraesthesia 42.72 11.76 421 352575 58523 32102007
Lymphadenopathy 42.43 11.76 151 352845 26931 32133599
Inappropriate schedule of product administration 42.36 11.76 307 352689 45518 32115012
Haematuria 42.20 11.76 749 352247 47612 32112918
Anhedonia 42.13 11.76 193 352803 8271 32152259
Polyuria 41.93 11.76 185 352811 7800 32152730
Back pain 41.78 11.76 903 352093 110150 32050380
Hypoglycaemic coma 41.69 11.76 86 352910 2357 32158173
Uveitis 41.62 11.76 9 352987 6341 32154189
Presyncope 41.60 11.76 326 352670 16975 32143555
Arrhythmia 41.55 11.76 575 352421 34728 32125802
Oliguria 41.16 11.76 188 352808 8046 32152484
Arthropathy 41.11 11.76 117 352879 22372 32138158
Migraine 41.00 11.76 55 352941 13930 32146600
Hypoaesthesia 40.95 11.76 420 352576 57933 32102597
Dyskinesia 40.83 11.76 126 352870 23477 32137053
Dyspnoea paroxysmal nocturnal 40.71 11.76 65 352931 1452 32159078
Diastolic dysfunction 40.55 11.76 137 352859 5087 32155443
Device interaction 40.43 11.76 40 352956 537 32159993
Diabetic ketoacidosis 40.10 11.76 84 352912 17848 32142682
Atrioventricular block 39.93 11.76 177 352819 7478 32153052
Anxiety 39.87 11.76 768 352228 95237 32065293
Neutrophil count decreased 39.26 11.76 325 352671 46814 32113716
Tremor 39.23 11.76 633 352363 80644 32079886
Iron deficiency anaemia 38.88 11.76 208 352788 9493 32151037
Gastrointestinal disorder 38.78 11.76 188 352808 30743 32129787
Concomitant disease aggravated 38.50 11.76 142 352854 5511 32155019
Acute respiratory failure 38.01 11.76 478 352518 28250 32132280
Generalised tonic-clonic seizure 38.01 11.76 107 352889 20532 32139998
Device issue 37.93 11.76 25 352971 8887 32151643
Upper gastrointestinal haemorrhage 37.86 11.76 411 352585 23438 32137092
Bundle branch block left 37.56 11.76 143 352853 5636 32154894
Blood pressure fluctuation 37.36 11.76 104 352892 20031 32140499
Cardiac arrest 36.97 11.76 1341 351655 95435 32065095
Product storage error 36.61 11.76 16 352980 7162 32153368
Blood potassium decreased 36.48 11.76 317 352679 17021 32143509
Chills 36.08 11.76 613 352383 77471 32083059
Nephrolithiasis 35.62 11.76 164 352832 27190 32133340
Memory impairment 35.59 11.76 275 352721 40204 32120326
Dialysis 35.49 11.76 227 352769 11061 32149469
Hallucination, auditory 35.40 11.76 36 352960 10314 32150216
Acrodermatitis enteropathica 35.34 11.76 10 352986 0 32160530
Withdrawal syndrome 35.20 11.76 48 352948 12074 32148456
Left ventricular dilatation 35.19 11.76 41 352955 670 32159860
Epistaxis 35.13 11.76 824 352172 55031 32105499
Euphoric mood 35.10 11.76 7 352989 5220 32155310
Ankylosing spondylitis 34.75 11.76 7 352989 5183 32155347
No adverse event 34.72 11.76 107 352889 19946 32140584
Hepatic cancer 34.50 11.76 163 352833 7077 32153453
Nightmare 34.48 11.76 56 352940 13110 32147420
Sleep disorder 33.89 11.76 162 352834 26590 32133940
White blood cell count decreased 33.87 11.76 743 352253 90455 32070075
Erythema 33.83 11.76 667 352329 82438 32078092
Vascular purpura 33.82 11.76 63 352933 1599 32158931
Anger 33.71 11.76 48 352948 11856 32148674
Oesophageal varices haemorrhage 33.70 11.76 93 352903 3086 32157444
Vision blurred 33.54 11.76 312 352684 43874 32116656
Cardiac output decreased 33.11 11.76 45 352951 865 32159665
Dystonia 32.98 11.76 40 352956 10583 32149947
Acute graft versus host disease 32.80 11.76 14 352982 6356 32154174
Cardiorenal syndrome 32.80 11.76 42 352954 760 32159770
Tuberculosis 32.64 11.76 28 352968 8701 32151829
Multiple organ dysfunction syndrome 32.31 11.76 990 352006 68864 32091666
Blood loss anaemia 32.11 11.76 171 352825 7791 32152739
Prostate cancer 31.85 11.76 171 352825 27235 32133295
Atrial flutter 31.63 11.76 277 352719 14906 32145624
Haemodialysis 31.63 11.76 217 352779 10829 32149701
Cardiac murmur 31.47 11.76 158 352838 7033 32153497
Transfusion 31.44 11.76 167 352829 7601 32152929
Cor pulmonale 31.35 11.76 40 352956 721 32159809
COVID-19 31.29 11.76 211 352785 31804 32128726
Diverticulitis 31.22 11.76 104 352892 18924 32141606
Depressed mood 30.73 11.76 99 352897 18201 32142329
Abdominal pain 30.65 11.76 1319 351677 148210 32012320
Sexual dysfunction 30.55 11.76 15 352981 6274 32154256
Blood creatine increased 30.48 11.76 119 352877 4746 32155784
Haematemesis 30.48 11.76 445 352551 27190 32133340
International normalised ratio decreased 30.43 11.76 115 352881 4516 32156014
Subdural haematoma 30.36 11.76 341 352655 19612 32140918
Basal cell carcinoma 30.23 11.76 94 352902 17474 32143056
Atrioventricular block complete 30.08 11.76 183 352813 8761 32151769
Cardiac amyloidosis 30.05 11.76 45 352951 949 32159581
Blood pressure increased 29.90 11.76 645 352351 78709 32081821
Injection site swelling 29.85 11.76 36 352960 9548 32150982
Poisoning deliberate 29.78 11.76 16 352980 6359 32154171
Hypoxia 29.75 11.76 759 352237 51373 32109157
Hypocoagulable state 29.57 11.76 45 352951 963 32159567
Eosinophilia 29.57 11.76 407 352589 24551 32135979
Pancreatitis 29.55 11.76 268 352728 37883 32122647
Influenza like illness 29.55 11.76 173 352823 26967 32133563
Mental disorder 29.39 11.76 72 352924 14476 32146054
Multiple sclerosis 29.22 11.76 24 352972 7620 32152910
Lipodystrophy acquired 29.21 11.76 3 352993 3679 32156851
Diplopia 29.18 11.76 72 352924 14440 32146090
Mania 29.14 11.76 37 352959 9595 32150935
Neuroleptic malignant syndrome 29.14 11.76 95 352901 17400 32143130
Cognitive disorder 28.76 11.76 164 352832 25730 32134800
Leukopenia 28.75 11.76 469 352527 59653 32100877
Dyspnoea at rest 28.68 11.76 91 352905 3268 32157262
Blood lactic acid 28.65 11.76 28 352968 370 32160160
Osteonecrosis of jaw 28.62 11.76 109 352887 19057 32141473
Panic attack 28.62 11.76 35 352961 9226 32151304
Arthritis 28.61 11.76 171 352825 26521 32134009
Premature baby 28.51 11.76 104 352892 18414 32142116
Night sweats 28.46 11.76 85 352911 16003 32144527
Therapeutic response shortened 28.39 11.76 8 352988 4712 32155818
Disturbance in attention 28.28 11.76 147 352849 23606 32136924
Paranoia 28.21 11.76 46 352950 10753 32149777
Mucormycosis 28.21 11.76 13 352983 5641 32154889
Congestive hepatopathy 28.19 11.76 64 352932 1876 32158654
Wrong technique in product usage process 28.16 11.76 244 352752 34815 32125715
Polyomavirus-associated nephropathy 28.16 11.76 3 352993 3574 32156956
Sudden cardiac death 28.14 11.76 98 352898 3696 32156834
Muscle spasms 28.11 11.76 567 352429 69851 32090679
Normochromic normocytic anaemia 27.98 11.76 104 352892 4051 32156479
Neoplasm progression 27.95 11.76 114 352882 19544 32140986
Nephrotic syndrome 27.93 11.76 155 352841 7174 32153356
Ventricular fibrillation 27.79 11.76 299 352697 17011 32143519
Hyperuricaemia 27.65 11.76 167 352829 7974 32152556
Dysphagia 27.63 11.76 485 352511 60991 32099539
Prothrombin time prolonged 27.55 11.76 191 352805 9564 32150966
Progressive multifocal leukoencephalopathy 27.42 11.76 38 352958 9493 32151037
Herpes zoster 27.37 11.76 222 352774 32119 32128411
Hyperhidrosis 27.23 11.76 577 352419 70591 32089939
Tinnitus 27.14 11.76 96 352900 17153 32143377
Syringe issue 27.05 11.76 4 352992 3707 32156823
Acute graft versus host disease in skin 26.99 11.76 10 352986 4947 32155583
Post transplant lymphoproliferative disorder 26.74 11.76 15 352981 5819 32154711
Hepatorenal syndrome 26.69 11.76 76 352920 2569 32157961
Injection site haemorrhage 26.60 11.76 32 352964 8496 32152034
Extrapyramidal disorder 26.36 11.76 56 352940 11839 32148691
Hepatotoxicity 26.34 11.76 114 352882 19223 32141307
Anal abscess 26.16 11.76 14 352982 5576 32154954
Left ventricular enlargement 25.99 11.76 34 352962 629 32159901
Myalgia 25.96 11.76 677 352319 80553 32079977
Priapism 25.65 11.76 11 352985 4980 32155550
Pulmonary congestion 25.61 11.76 237 352759 12954 32147576
Nephrogenic anaemia 25.61 11.76 68 352928 2205 32158325
Amnesia 25.48 11.76 163 352833 24873 32135657
Somnolence 25.31 11.76 897 352099 102900 32057630
Therapeutic response decreased 25.24 11.76 171 352825 25749 32134781
Product quality issue 25.23 11.76 115 352881 19118 32141412
Mood altered 25.12 11.76 36 352960 8868 32151662
Pseudoporphyria 25.06 11.76 22 352974 251 32160279
Ventricular extrasystoles 24.84 11.76 219 352777 11807 32148723
Pericardial effusion 24.81 11.76 369 352627 22633 32137897
Dilatation atrial 24.70 11.76 65 352931 2096 32158434
Respiratory depression 24.69 11.76 68 352928 13143 32147387
Pneumocystis jirovecii pneumonia 24.65 11.76 113 352883 18757 32141773
Pericardial haemorrhage 24.01 11.76 81 352915 3005 32157525
Graft versus host disease 23.84 11.76 51 352945 10755 32149775
Bradyarrhythmia 23.82 11.76 64 352932 2090 32158440
Incorrect dose administered 23.80 11.76 254 352742 34774 32125756
Alopecia 23.73 11.76 130 352866 20600 32139930
Tenosynovitis 23.72 11.76 6 352990 3797 32156733
Neurotoxicity 23.62 11.76 84 352912 14986 32145544
Aspergillus infection 23.61 11.76 57 352939 11517 32149013
Virologic failure 23.57 11.76 6 352990 3781 32156749
Dilatation ventricular 23.51 11.76 74 352922 2646 32157884
Multiple-drug resistance 23.46 11.76 6 352990 3769 32156761
Chronic hepatic failure 23.35 11.76 29 352967 508 32160022
Ventricular failure 23.30 11.76 15 352981 102 32160428
Neutropenic sepsis 23.26 11.76 66 352930 12633 32147897
Emotional distress 23.17 11.76 275 352721 16031 32144499
Diffuse large B-cell lymphoma 23.10 11.76 35 352961 8427 32152103
Oropharyngeal pain 23.10 11.76 223 352773 31129 32129401
Musculoskeletal pain 23.03 11.76 228 352768 31669 32128861
Epilepsy 22.98 11.76 143 352853 21966 32138564
Tardive dyskinesia 22.89 11.76 16 352980 5515 32155015
Neuromyopathy 22.79 11.76 40 352956 968 32159562
Injection site bruising 22.67 11.76 31 352965 7789 32152741
Intraocular pressure increased 22.59 11.76 17 352979 5641 32154889
Blood pressure systolic decreased 22.56 11.76 99 352897 4164 32156366
Eye pain 22.48 11.76 69 352927 12879 32147651
Hepatitis B reactivation 22.38 11.76 5 352991 3444 32157086
Cardiac valve disease 22.33 11.76 80 352916 3060 32157470
Tachycardia 22.24 11.76 671 352325 78417 32082113
Haemophagocytic lymphohistiocytosis 22.20 11.76 57 352939 11278 32149252
Aortic valve incompetence 22.14 11.76 115 352881 5188 32155342
Mood swings 22.07 11.76 34 352962 8131 32152399
Feeling abnormal 21.93 11.76 494 352502 59929 32100601
C-reactive protein abnormal 21.86 11.76 22 352974 6334 32154196
Abdominal discomfort 21.82 11.76 421 352575 52203 32108327
Varices oesophageal 21.69 11.76 88 352908 3573 32156957
Crohn's disease 21.66 11.76 10 352986 4335 32156195
Influenza 21.65 11.76 360 352636 45654 32114876
Vascular graft 21.64 11.76 49 352947 1434 32159096
Mitral valve thickening 21.62 11.76 25 352971 405 32160125
Salivary hypersecretion 21.56 11.76 34 352962 8054 32152476
Hypercreatinaemia 21.44 11.76 16 352980 142 32160388
Hydrothorax 21.44 11.76 28 352968 517 32160013
Atrial tachycardia 21.43 11.76 62 352934 2115 32158415
Dermatitis bullous 21.36 11.76 133 352863 6420 32154110
Hypervolaemia 21.31 11.76 69 352927 2505 32158025
Renal ischaemia 21.28 11.76 29 352967 559 32159971
Occult blood positive 21.16 11.76 94 352902 3975 32156555
Hypocalcaemia 21.16 11.76 360 352636 22694 32137836
Low cardiac output syndrome 21.11 11.76 25 352971 416 32160114
Hypercapnia 21.11 11.76 95 352901 4040 32156490
Maternal drugs affecting foetus 21.08 11.76 10 352986 4267 32156263
Bronchopulmonary aspergillosis 20.98 11.76 77 352919 13610 32146920
Gastrointestinal vascular malformation haemorrhagic 20.97 11.76 29 352967 567 32159963
Restlessness 20.96 11.76 171 352825 24710 32135820
On and off phenomenon 20.94 11.76 6 352990 3495 32157035
Bone pain 20.93 11.76 132 352864 20212 32140318
Toxic epidermal necrolysis 20.92 11.76 327 352669 20266 32140264
Emotional disorder 20.90 11.76 17 352979 5424 32155106
Alcohol poisoning 20.88 11.76 5 352991 3284 32157246
Drug screen positive 20.78 11.76 10 352986 4231 32156299
Therapy partial responder 20.75 11.76 14 352982 4916 32155614
Epstein-Barr virus infection 20.66 11.76 28 352968 7062 32153468
Mental impairment 20.66 11.76 49 352947 9963 32150567
Flushing 20.63 11.76 227 352769 30900 32129630
Coma hepatic 20.57 11.76 26 352970 464 32160066
Hyponatraemic syndrome 20.56 11.76 19 352977 233 32160297
Frequent bowel movements 20.53 11.76 45 352951 9407 32151123
Suspected suicide 20.45 11.76 4 352992 3024 32157506
Dysmorphism 20.38 11.76 3 352993 2790 32157740
Viral mutation identified 20.36 11.76 4 352992 3015 32157515
Unevaluable event 20.35 11.76 493 352503 33093 32127437
Adverse drug reaction 20.32 11.76 181 352815 25680 32134850
Osteonecrosis 20.28 11.76 102 352894 16520 32144010
Apparent death 20.18 11.76 7 352989 3608 32156922
Injection site mass 20.14 11.76 18 352978 5483 32155047
Scrotal oedema 20.13 11.76 50 352946 1555 32158975
Crepitations 20.08 11.76 77 352919 3045 32157485
Microcytic anaemia 19.93 11.76 61 352935 2148 32158382
Hypersensitivity vasculitis 19.87 11.76 86 352910 3595 32156935
Enteritis 19.85 11.76 30 352966 7231 32153299
Alcohol abuse 19.78 11.76 12 352984 4460 32156070
Muscle twitching 19.76 11.76 41 352955 8743 32151787
Prerenal failure 19.72 11.76 58 352938 1997 32158533
Atrioventricular block first degree 19.69 11.76 119 352877 5684 32154846
Pruritus 19.66 11.76 1170 351826 127532 32032998
Left ventricular hypertrophy 19.60 11.76 135 352861 6745 32153785
Hepatitis B 19.56 11.76 24 352972 6317 32154213
Chronic graft versus host disease 19.52 11.76 12 352984 4428 32156102
Respiratory arrest 19.49 11.76 210 352786 28698 32131832
Pulmonary arterial pressure increased 19.34 11.76 41 352955 1146 32159384
Delusion 19.28 11.76 75 352921 13033 32147497
Blood creatinine abnormal 19.28 11.76 62 352934 2243 32158287
Eyelid ptosis 19.27 11.76 19 352977 5523 32155007
Feeling hot 19.27 11.76 106 352890 16780 32143750
Abnormal dreams 19.24 11.76 40 352956 8524 32152006
Packed red blood cell transfusion 19.16 11.76 50 352946 1604 32158926
Blood uric acid increased 19.11 11.76 130 352866 6469 32154061
Anticoagulation drug level increased 19.01 11.76 26 352970 503 32160027
Catatonia 18.99 11.76 14 352982 4694 32155836
Lower gastrointestinal haemorrhage 18.96 11.76 162 352834 8655 32151875
Candida infection 18.89 11.76 106 352890 16697 32143833
Nephrocalcinosis 18.89 11.76 28 352968 585 32159945
Posterior reversible encephalopathy syndrome 18.87 11.76 48 352948 9528 32151002
Metabolic acidosis 18.86 11.76 577 352419 40122 32120408
Arteriospasm coronary 18.85 11.76 4 352992 2856 32157674
Ammonia increased 18.77 11.76 97 352899 4367 32156163
Visual impairment 18.69 11.76 248 352748 32640 32127890
Cellulitis 18.67 11.76 694 352302 49536 32110994
Pulmonary tuberculosis 18.66 11.76 16 352980 4973 32155557
Graft versus host disease in gastrointestinal tract 18.64 11.76 7 352989 3434 32157096
Incorrect route of product administration 18.62 11.76 65 352931 11661 32148869
Ventricular internal diameter abnormal 18.61 11.76 13 352983 103 32160427
Ischaemic stroke 18.59 11.76 281 352715 17295 32143235
Impaired work ability 18.46 11.76 22 352974 5866 32154664
Graft versus host disease in skin 18.43 11.76 8 352988 3596 32156934
Electrocardiogram QT prolonged 18.37 11.76 562 352434 39079 32121451
Cardio-respiratory distress 18.35 11.76 15 352981 154 32160376
Ventricular hypokinesia 18.25 11.76 103 352893 4797 32155733
Upper motor neurone lesion 18.21 11.76 13 352983 107 32160423
Faeces discoloured 18.19 11.76 244 352752 14633 32145897
Apathy 18.11 11.76 28 352968 6687 32153843
Posthaemorrhagic hydrocephalus 18.03 11.76 12 352984 87 32160443
Speech disorder 17.98 11.76 190 352806 26063 32134467
Anal fistula 17.94 11.76 13 352983 4398 32156132
Hypercreatininaemia 17.86 11.76 26 352970 534 32159996
Tendonitis 17.83 11.76 43 352953 8692 32151838
Pneumonia 17.78 11.76 4231 348765 351021 31809509
Road traffic accident 17.77 11.76 113 352883 17268 32143262
Dermatitis exfoliative generalised 17.73 11.76 77 352919 3224 32157306
Inflammatory bowel disease 17.71 11.76 3 352993 2515 32158015
Gastrointestinal angiodysplasia 17.55 11.76 28 352968 625 32159905
Muscle haemorrhage 17.52 11.76 86 352910 3793 32156737
Maternal exposure during pregnancy 17.51 11.76 13 352983 4344 32156186
Hepatic steatosis 17.48 11.76 103 352893 16030 32144500
Status epilepticus 17.46 11.76 69 352927 11937 32148593
Haemoptysis 17.37 11.76 482 352514 33043 32127487
Atrial septal defect 17.36 11.76 31 352965 6994 32153536
Peripheral venous disease 17.36 11.76 64 352932 2483 32158047
Unintentional medical device removal 17.32 11.76 3 352993 2475 32158055
Gastric varices 17.32 11.76 23 352973 432 32160098
Product substitution issue 17.15 11.76 57 352939 10379 32150151
Central nervous system lesion 17.03 11.76 23 352973 5809 32154721
Cytomegalovirus chorioretinitis 16.97 11.76 9 352987 3603 32156927
Drug-induced liver injury 16.95 11.76 173 352823 23890 32136640
Ear infection 16.92 11.76 42 352954 8406 32152124
Gastritis haemorrhagic 16.92 11.76 42 352954 1306 32159224
Medication error 16.89 11.76 341 352655 22194 32138336
Spontaneous haematoma 16.87 11.76 25 352971 522 32160008
Second primary malignancy 16.82 11.76 31 352965 6910 32153620
Knee arthroplasty 16.75 11.76 24 352972 5913 32154617
Ejection fraction 16.72 11.76 11 352985 78 32160452
Hepatic enzyme increased 16.70 11.76 292 352704 36745 32123785
Respiratory distress 16.68 11.76 501 352495 34745 32125785
Small for dates baby 16.62 11.76 8 352988 3385 32157145
Renal artery thrombosis 16.52 11.76 19 352977 306 32160224
Abdominal cavity drainage 16.47 11.76 20 352976 342 32160188
Crying 16.47 11.76 24 352972 5872 32154658
Creatinine renal clearance decreased 16.43 11.76 79 352917 3455 32157075
Throat irritation 16.35 11.76 53 352943 9725 32150805
Ventricular dyssynchrony 16.30 11.76 7 352989 17 32160513
Acquired macroglossia 16.30 11.76 7 352989 17 32160513
Base excess decreased 16.28 11.76 16 352980 213 32160317
Paracentesis 16.23 11.76 21 352975 384 32160146
Hypertriglyceridaemia 16.20 11.76 45 352951 8674 32151856
Acute lymphocytic leukaemia 16.19 11.76 9 352987 3509 32157021
Cardiac ablation 16.16 11.76 27 352969 627 32159903
Drug abuser 16.16 11.76 13 352983 4171 32156359
Cardioactive drug level decreased 16.14 11.76 10 352986 63 32160467
Post procedural haematoma 16.10 11.76 46 352950 1558 32158972
Strongyloidiasis 16.05 11.76 4 352992 2557 32157973
Ecchymosis 16.05 11.76 128 352868 6700 32153830
Weight decreased 16.01 11.76 1556 351440 163262 31997268
Hypoperfusion 16.00 11.76 36 352960 1049 32159481
Hypomagnesaemia 15.95 11.76 290 352706 18515 32142015
Gastritis erosive 15.85 11.76 116 352880 5911 32154619
International normalised ratio fluctuation 15.80 11.76 36 352960 1058 32159472
International normalised ratio abnormal 15.63 11.76 74 352922 3215 32157315
Bone marrow failure 15.60 11.76 234 352762 30170 32130360
Photophobia 15.55 11.76 29 352967 6435 32154095
Asterixis 15.47 11.76 40 352956 1276 32159254
Urinary tract discomfort 15.41 11.76 13 352983 140 32160390
Cardiospasm 15.35 11.76 5 352991 3 32160527
Thirst decreased 15.35 11.76 5 352991 3 32160527
Diabetic nephropathy 15.35 11.76 55 352941 2104 32158426
Peripheral vascular disorder 15.35 11.76 104 352892 5168 32155362
Base excess increased 15.28 11.76 9 352987 51 32160479
Left ventricle outflow tract obstruction 15.26 11.76 13 352983 142 32160388
Bipolar disorder 15.26 11.76 12 352984 3894 32156636
Drug specific antibody present 15.23 11.76 4 352992 2469 32158061
Purpura 15.17 11.76 178 352818 10347 32150183
Hypochromasia 15.17 11.76 19 352977 336 32160194
Alanine aminotransferase abnormal 15.15 11.76 7 352989 3033 32157497
Coagulation time prolonged 15.11 11.76 41 352955 1347 32159183
Oxygen consumption decreased 15.06 11.76 14 352982 173 32160357
Sinus node dysfunction 15.06 11.76 85 352911 3959 32156571
Polyneuropathy 15.05 11.76 83 352913 13132 32147398
Brain natriuretic peptide abnormal 15.00 11.76 19 352977 340 32160190
Social avoidant behaviour 14.99 11.76 8 352988 3191 32157339
Middle insomnia 14.81 11.76 30 352966 6454 32154076
Dependence on oxygen therapy 14.81 11.76 14 352982 177 32160353
Hyperparathyroidism secondary 14.81 11.76 37 352959 1155 32159375
Left atrial enlargement 14.79 11.76 26 352970 630 32159900
Mitral valve calcification 14.77 11.76 25 352971 587 32159943
Increased appetite 14.76 11.76 30 352966 6446 32154084
Sinus arrhythmia 14.75 11.76 29 352967 767 32159763
Squamous cell carcinoma 14.73 11.76 65 352931 10903 32149627
Troponin increased 14.71 11.76 169 352827 9773 32150757
Device use error 14.69 11.76 3 352993 2200 32158330
Neonatal respiratory distress syndrome 14.67 11.76 14 352982 4133 32156397
Amyloidosis 14.67 11.76 56 352940 2210 32158320
Ejection fraction abnormal 14.62 11.76 32 352964 915 32159615
Malignant melanoma 14.60 11.76 42 352954 8004 32152526
Muscle rigidity 14.60 11.76 67 352929 11119 32149411
Subarachnoid haemorrhage 14.53 11.76 175 352821 10236 32150294
Gouty arthritis 14.51 11.76 35 352961 1068 32159462
Pseudo-Bartter syndrome 14.43 11.76 6 352990 13 32160517
Coronary arterial stent insertion 14.40 11.76 87 352909 4155 32156375
Pulmonary arterial wedge pressure increased 14.27 11.76 11 352985 103 32160427
Exercise tolerance decreased 14.26 11.76 92 352904 4496 32156034
Cystic fibrosis 14.25 11.76 4 352992 2362 32158168
Visual field defect 14.25 11.76 17 352979 4530 32156000
Freezing phenomenon 14.22 11.76 4 352992 2359 32158171
Head injury 14.15 11.76 270 352726 17393 32143137
Phlebitis deep 14.13 11.76 6 352990 14 32160516
Ventricular dysfunction 14.13 11.76 79 352917 3667 32156863
Acquired haemophilia 14.10 11.76 31 352965 889 32159641
Right ventricular dysfunction 14.07 11.76 33 352963 989 32159541
Disorganised speech 14.02 11.76 27 352969 703 32159827
Dizziness 14.00 11.76 2532 350464 207086 31953444
Right atrial enlargement 13.99 11.76 16 352980 256 32160274
Disinhibition 13.97 11.76 6 352990 2714 32157816
Electrocardiogram T wave peaked 13.90 11.76 23 352973 530 32160000
Cataract 13.87 11.76 182 352814 24001 32136529
Adult failure to thrive 13.79 11.76 5 352991 6 32160524
Abscess 13.78 11.76 64 352932 10586 32149944
Uraemic encephalopathy 13.77 11.76 17 352979 296 32160234
Hypogammaglobulinaemia 13.75 11.76 29 352967 6147 32154383
Angina unstable 13.64 11.76 199 352797 12156 32148374
Coagulopathy 13.61 11.76 293 352703 19284 32141246
Heart sounds abnormal 13.57 11.76 25 352971 629 32159901
BK virus infection 13.51 11.76 20 352976 4861 32155669
Angina pectoris 13.37 11.76 441 352555 30985 32129545
Pulmonary vein stenosis 13.36 11.76 8 352988 47 32160483
Melanoderma 13.29 11.76 13 352983 172 32160358
Injection site pruritus 13.22 11.76 29 352967 6061 32154469
Hallucination 13.21 11.76 453 352543 52166 32108364
Endophthalmitis 13.21 11.76 14 352982 3935 32156595
Viral load increased 13.19 11.76 9 352987 3141 32157389
Gastrointestinal tract mucosal pigmentation 13.17 11.76 18 352978 348 32160182
Encephalopathy 13.14 11.76 475 352521 33782 32126748
Haematocrit decreased 13.13 11.76 443 352553 31219 32129311
Euglycaemic diabetic ketoacidosis 13.10 11.76 7 352989 2791 32157739
Viral infection 13.09 11.76 113 352883 16137 32144393
Cardiac failure high output 13.06 11.76 7 352989 32 32160498
Transaminases increased 13.05 11.76 192 352804 24836 32135694
Pericarditis constrictive 13.03 11.76 16 352980 277 32160253
Meningitis aseptic 12.91 11.76 6 352990 2591 32157939
Hypoalbuminaemia 12.89 11.76 190 352806 11632 32148898
Neck pain 12.88 11.76 172 352824 22615 32137915
Anticoagulation drug level above therapeutic 12.88 11.76 48 352948 1872 32158658
Degenerative aortic valve disease 12.85 11.76 6 352990 19 32160511
Gastrointestinal arteriovenous malformation 12.83 11.76 18 352978 357 32160173
C-reactive protein increased 12.81 11.76 411 352585 47691 32112839
Alanine aminotransferase increased 12.77 11.76 709 352287 77770 32082760
Intervertebral disc protrusion 12.69 11.76 57 352939 9514 32151016
Scrotal swelling 12.68 11.76 39 352957 1377 32159153
Haemorrhagic arteriovenous malformation 12.68 11.76 18 352978 361 32160169
Liver function test increased 12.66 11.76 82 352914 12478 32148052
Impulsive behaviour 12.64 11.76 4 352992 2185 32158345
Activated partial thromboplastin time prolonged 12.64 11.76 144 352852 8311 32152219
Lividity 12.62 11.76 12 352984 153 32160377
Haemoconcentration 12.60 11.76 8 352988 53 32160477
Ketoacidosis 12.59 11.76 16 352980 4148 32156382
Pruritus genital 12.56 11.76 23 352973 576 32159954
Cardiac asthma 12.53 11.76 14 352982 218 32160312
Oesophageal variceal ligation 12.52 11.76 9 352987 75 32160455
Right atrial dilatation 12.50 11.76 17 352979 327 32160203
Grip strength decreased 12.50 11.76 5 352991 2360 32158170
Cytomegalovirus infection reactivation 12.44 11.76 11 352985 3368 32157162
Diverticulum intestinal haemorrhagic 12.42 11.76 52 352944 2142 32158388
Affective disorder 12.41 11.76 12 352984 3521 32157009
Ischaemic hepatitis 12.40 11.76 44 352952 1675 32158855
Long QT syndrome 12.36 11.76 59 352937 2572 32157958
Alkalosis 12.36 11.76 11 352985 128 32160402
Gouty tophus 12.36 11.76 11 352985 128 32160402
Anaphylactic shock 12.35 11.76 104 352892 14930 32145600
Adenovirus infection 12.32 11.76 20 352976 4684 32155846
Muscle spasticity 12.31 11.76 28 352968 5777 32154753
Heparin-induced thrombocytopenia 12.29 11.76 105 352891 5609 32154921
Ectopic gastric mucosa 12.29 11.76 5 352991 10 32160520
Narrow anterior chamber angle 12.29 11.76 5 352991 10 32160520
Peritoneal dialysis 12.26 11.76 22 352974 542 32159988
Blood sodium decreased 12.25 11.76 249 352747 16225 32144305
Skin toxicity 12.17 11.76 14 352982 3792 32156738
Blood potassium abnormal 12.17 11.76 35 352961 1190 32159340
Nephrogenic systemic fibrosis 12.17 11.76 85 352911 4267 32156263
Cryptorchism 12.16 11.76 3 352993 1931 32158599
Gastric ulcer 12.11 11.76 240 352756 15569 32144961
Blindness 12.09 11.76 88 352908 13038 32147492
Pulmonary hypertensive crisis 12.08 11.76 12 352984 162 32160368
Obsessive-compulsive disorder 11.99 11.76 22 352974 4912 32155618
Mumps 11.98 11.76 10 352986 106 32160424
Pulmonary arterial pressure abnormal 11.96 11.76 13 352983 196 32160334
Cerebral haemorrhage 11.94 11.76 476 352520 34271 32126259
Blood urea abnormal 11.93 11.76 27 352969 790 32159740
Kidney small 11.91 11.76 8 352988 59 32160471
Diabetic foot 11.91 11.76 63 352933 2863 32157667
Alcohol interaction 11.84 11.76 5 352991 2284 32158246
Stasis dermatitis 11.83 11.76 28 352968 844 32159686
Fabry's disease 11.81 11.76 6 352990 24 32160506
Conjunctival scar 11.80 11.76 8 352988 60 32160470
Tic 11.79 11.76 4 352992 2090 32158440

Pharmacologic Action:

SourceCodeDescription
ATC C03CA01 CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Sulfonamides, plain
ATC C03CB01 CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Sulfonamides and potassium in combination
ATC C03EB01 CARDIOVASCULAR SYSTEM
DIURETICS
DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
High-ceiling diuretics and potassium-sparing agents
FDA PE N0000175366 Increased Diuresis at Loop of Henle
FDA EPC N0000175590 Loop Diuretic
MeSH PA D004232 Diuretics
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D045283 Natriuretic Agents
MeSH PA D049994 Sodium Potassium Chloride Symporter Inhibitors
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:77608 loop diuretics
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Acute pulmonary edema indication 40541001
Decompensated cardiac failure indication 195111005
Edema indication 267038008
Pulmonary Edema due to Chronic Heart Failure indication
Edema due to Hepatic Cirrhosis indication
Peripheral Edema due to Chronic Heart Failure indication
Hypercalcemia off-label use 66931009 DOID:12678
Prevention of Oliguria off-label use
Metabolic alkalosis contraindication 1388004
Anuria contraindication 2472002 DOID:2983
Hypocalcemia contraindication 5291005
Hypochloremia contraindication 10399008
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Diabetes mellitus contraindication 73211009 DOID:9351
Pancreatitis contraindication 75694006 DOID:4989
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Hearing disorder contraindication 128540005
Hypomagnesemia contraindication 190855004
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Azotemia contraindication 445009001

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.69 acidic
pKa2 10.59 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Solute carrier family 12 member 1 Transporter INHIBITOR IC50 6.20 WOMBAT-PK CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-1 Transporter WOMBAT-PK
Carbonic anhydrase 2 Enzyme Ki 7.19 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 7.21 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 6.25 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 6.38 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 6.58 CHEMBL
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 6.30 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 6.49 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 6.29 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 6.61 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 7.28 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme IC50 5.42 CHEMBL
Solute carrier family 12 member 2 Transporter INHIBITOR IC50 5.13 IUPHAR
G-protein coupled receptor 35 GPCR Ki 5.49 CHEMBL
CDGSH iron-sulfur domain-containing protein 1 Unclassified Ki 5.64 CHEMBL
Carbonic anhydrase 13 Enzyme Ki 6.26 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme IC50 5.42 CHEMBL
Holo-[acyl-carrieir-protein] synthase Enzyme IC50 4.90 CHEMBL

External reference:

IDSource
4017830 VUID
N0000146188 NUI
D00331 KEGG_DRUG
4017830 VANDF
C0016860 UMLSCUI
CHEBI:47426 CHEBI
FUN PDB_CHEM_ID
CHEMBL35 ChEMBL_ID
CHEMBL1788133 ChEMBL_ID
DB00695 DRUGBANK_ID
D005665 MESH_DESCRIPTOR_UI
3440 PUBCHEM_CID
4839 IUPHAR_LIGAND_ID
1584 INN_ID
7LXU5N7ZO5 UNII
4603 RXNORM
3962 MMSL
4769 MMSL
d00070 MMSL
002307 NDDF
387475002 SNOMEDCT_US
81609008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-3294 SOLUTION 10 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-3298 SOLUTION 40 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4297 TABLET 20 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4299 TABLET 40 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4301 TABLET 80 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8297 TABLET 20 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8299 TABLET 40 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8301 TABLET 80 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0208 TABLET 20 mg ORAL NDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0216 TABLET 40 mg ORAL NDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0232 TABLET 80 mg ORAL ANDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0404-9861 INJECTION, SOLUTION 10 mg INTRAMUSCULAR ANDA 12 sections
FUROSEMIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9862 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0404-9863 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 13 sections
FUROSEMIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9864 INJECTION, SOLUTION 20 mg INTRAMUSCULAR ANDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0409-1639 INJECTION, SOLUTION 10 mg INTRAMUSCULAR ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0409-6102 INJECTION, SOLUTION 10 mg INTRAMUSCULAR NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0409-6102 INJECTION, SOLUTION 10 mg INTRAMUSCULAR NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0409-9631 INJECTION, SOLUTION 10 mg INTRAMUSCULAR ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7937 TABLET 20 mg ORAL NDA 11 sections
Fuosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7938 TABLET 40 mg ORAL NDA 11 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7957 TABLET 80 mg ORAL ANDA 11 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-8368 TABLET 20 mg ORAL ANDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-8369 TABLET 40 mg ORAL ANDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-8370 TABLET 80 mg ORAL ANDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0904-7177 TABLET 20 mg ORAL ANDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0904-7178 TABLET 40 mg ORAL ANDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 10544-131 TABLET 20 mg ORAL ANDA 13 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 10544-584 TABLET 40 mg ORAL ANDA 13 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 12634-416 TABLET 20 mg ORAL ANDA 18 sections