furosemide ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diuretics, furosemide derivatives 1258 54-31-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • frusemide
  • furosemide
  • furosemid
A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
  • Molecular weight: 330.74
  • Formula: C12H11ClN2O5S
  • CLOGP: 1.90
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 122.63
  • ALOGS: -3.45
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
40 mg O
40 mg P
40 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 66 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 25.92 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 71 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.12 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 1, 1966 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 2834.82 10.16 6311 450775 221747 49926291
Cardiac failure congestive 2306.88 10.16 3301 453785 81081 50066957
Drug ineffective 1831.84 10.16 2873 454213 816460 49331578
Cardiac failure 1339.51 10.16 2437 454649 73603 50074435
Hyperkalaemia 1322.91 10.16 1888 455198 46201 50101837
Pemphigus 1029.78 10.16 10 457076 120156 50027882
Hyponatraemia 980.08 10.16 2467 454619 93672 50054366
Contraindicated product administered 839.93 10.16 163 456923 148795 49999243
Glossodynia 828.05 10.16 55 457031 115514 50032524
Hand deformity 805.86 10.16 21 457065 100178 50047860
Oedema peripheral 798.82 10.16 3180 453906 154781 49993257
Renal failure 798.30 10.16 2445 454641 104188 50043850
International normalised ratio increased 769.54 10.16 1391 455695 41761 50106277
Systemic lupus erythematosus 745.64 10.16 177 456909 140445 50007593
Drug intolerance 743.87 10.16 537 456549 218567 49929471
Alopecia 736.98 10.16 677 456409 244370 49903668
Hypotension 734.08 10.16 4118 452968 231351 49916687
Maternal exposure during pregnancy 712.11 10.16 276 456810 159502 49988536
Rheumatoid arthritis 705.25 10.16 483 456603 202067 49945971
Treatment failure 688.17 10.16 195 456891 137442 50010596
Arthropathy 680.54 10.16 287 456799 157619 49990419
Drug interaction 668.92 10.16 3561 453525 196060 49951978
Off label use 666.44 10.16 2137 454949 472289 49675749
Infusion related reaction 654.67 10.16 358 456728 169199 49978839
Hypokalaemia 641.12 10.16 1999 455087 85993 50062045
Dyspnoea 638.58 10.16 7646 449440 539962 49608076
Atrial fibrillation 633.37 10.16 2191 454895 99554 50048484
Therapeutic product effect decreased 607.85 10.16 234 456852 135816 50012222
Anaemia 565.92 10.16 4060 453026 248396 49899642
Drug hypersensitivity 553.67 10.16 883 456203 250127 49897911
Bradycardia 553.41 10.16 1552 455534 62874 50085164
Abdominal discomfort 539.60 10.16 785 456301 230856 49917182
Pain 517.99 10.16 3091 453995 575812 49572226
Joint swelling 516.67 10.16 889 456197 244397 49903641
Pulmonary hypertension 509.87 10.16 1008 456078 32409 50115629
Synovitis 505.59 10.16 243 456843 123622 50024416
Arthralgia 495.48 10.16 2160 454926 436542 49711496
Pulmonary arterial hypertension 491.06 10.16 751 456335 19568 50128470
Pericarditis 488.35 10.16 66 457020 78623 50069415
Hypersensitivity 473.29 10.16 758 456328 214403 49933635
Completed suicide 437.19 10.16 331 456755 131558 50016480
Renal impairment 427.64 10.16 1579 455507 74082 50073956
Rheumatoid factor positive 423.06 10.16 5 457081 49854 50098184
Melaena 422.74 10.16 821 456265 26043 50121995
Rash 422.39 10.16 2277 454809 435194 49712844
Discomfort 419.33 10.16 228 456858 108152 50039886
Fluid retention 414.33 10.16 1199 455887 49450 50098588
Fall 408.40 10.16 4721 452365 330211 49817827
Right ventricular failure 407.66 10.16 604 456482 15289 50132749
Gastrointestinal haemorrhage 399.25 10.16 1512 455574 71809 50076229
Dehydration 395.48 10.16 2543 454543 149906 49998132
Oedema 394.40 10.16 1462 455624 68719 50079319
Wound 391.50 10.16 235 456851 105559 50042479
Product use issue 382.91 10.16 472 456614 149003 49999035
Blood creatinine increased 372.95 10.16 1519 455567 74641 50073397
Hepatic enzyme increased 364.45 10.16 422 456664 136958 50011080
Myocardial infarction 364.26 10.16 1682 455404 87345 50060693
Musculoskeletal stiffness 354.69 10.16 382 456704 128099 50019939
Duodenal ulcer perforation 354.22 10.16 13 457073 45598 50102440
Helicobacter infection 324.81 10.16 35 457051 49667 50098371
Pulmonary oedema 319.27 10.16 1071 456015 47867 50100171
Blood urea increased 319.04 10.16 677 456409 22908 50125130
Lactic acidosis 306.64 10.16 824 456262 32531 50115507
Syncope 301.47 10.16 1773 455313 101229 50046809
Exposure during pregnancy 299.61 10.16 392 456694 120623 50027415
Orthostatic hypotension 292.14 10.16 749 456337 28732 50119306
Torsade de pointes 290.99 10.16 441 456645 11394 50136644
Injection site pain 285.92 10.16 349 456737 110675 50037363
Hypervolaemia 285.65 10.16 679 456407 24820 50123218
Hypoglycaemia 284.26 10.16 1096 455990 52485 50095553
Sinusitis 282.88 10.16 708 456378 169850 49978188
Folliculitis 276.93 10.16 20 457066 39205 50108833
Fatigue 276.39 10.16 4617 452469 702984 49445054
Injection site erythema 266.77 10.16 174 456912 74762 50073276
Muscle injury 264.67 10.16 18 457068 37093 50110945
Abortion spontaneous 264.03 10.16 33 457053 41739 50106299
Sleep disorder due to general medical condition, insomnia type 247.57 10.16 8 457078 31439 50116599
Pleural effusion 245.37 10.16 1413 455673 80041 50067997
Injection site reaction 240.58 10.16 76 457010 49956 50098082
Swelling 240.26 10.16 966 456120 199906 49948132
Ascites 226.99 10.16 777 456309 35084 50112954
Therapeutic product effect incomplete 226.93 10.16 296 456790 91219 50056819
Irritable bowel syndrome 222.18 10.16 93 456993 51348 50096690
Metabolic alkalosis 218.52 10.16 188 456898 2543 50145495
Nasopharyngitis 206.17 10.16 968 456118 191959 49956079
Device expulsion 205.48 10.16 14 457072 28808 50119230
Chronic kidney disease 203.18 10.16 804 456282 38967 50109071
Gastrointestinal disorder 199.73 10.16 341 456745 94115 50053923
Cardioactive drug level increased 197.35 10.16 155 456931 1829 50146209
Rhabdomyolysis 193.79 10.16 782 456304 38245 50109793
Pneumonia 185.79 10.16 4600 452486 373801 49774237
Creatinine renal clearance decreased 185.54 10.16 362 456724 11519 50136519
Respiratory failure 183.01 10.16 1430 455656 89751 50058287
Haematoma 182.64 10.16 649 456437 29861 50118177
Ill-defined disorder 176.11 10.16 141 456945 54513 50093525
Electrocardiogram QT prolonged 170.78 10.16 922 456164 50964 50097074
Cardiac failure chronic 169.01 10.16 184 456902 3379 50144659
Chronic obstructive pulmonary disease 168.14 10.16 938 456148 52497 50095541
Injection site swelling 165.72 10.16 85 457001 41688 50106350
Intentional overdose 164.55 10.16 193 456893 62311 50085727
Urine output decreased 157.27 10.16 313 456773 10108 50137930
Intentional product use issue 156.88 10.16 284 456802 76634 50071404
Psoriatic arthropathy 155.76 10.16 118 456968 46914 50101124
Cardiac failure acute 154.74 10.16 272 456814 7978 50140060
Hypoxia 153.99 10.16 887 456199 50236 50097802
Injection site pruritus 153.33 10.16 87 456999 40324 50107714
Rectal haemorrhage 152.79 10.16 722 456364 37836 50110202
Urticaria 149.82 10.16 631 456455 128930 50019108
Hepatic encephalopathy 149.74 10.16 293 456793 9343 50138695
Suicide attempt 149.22 10.16 148 456938 51584 50096454
Dyspnoea exertional 149.19 10.16 881 456205 50352 50097686
Haemoglobin decreased 148.11 10.16 1779 455307 125437 50022601
Impaired healing 145.63 10.16 254 456832 69532 50078506
Injection site bruising 142.63 10.16 77 457009 36691 50111347
Multiple organ dysfunction syndrome 142.35 10.16 859 456227 49478 50098560
Lower respiratory tract infection 141.32 10.16 417 456669 94784 50053254
Acute myocardial infarction 137.78 10.16 577 456509 28696 50119342
Product use in unapproved indication 137.69 10.16 558 456528 115261 50032777
Pregnancy 135.10 10.16 49 457037 29528 50118510
Rheumatic fever 133.81 10.16 4 457082 16863 50131175
Coronary artery disease 133.77 10.16 578 456508 29148 50118890
Stomatitis 133.63 10.16 468 456618 100876 50047162
Ventricular tachycardia 133.63 10.16 379 456707 15442 50132596
Headache 133.00 10.16 3522 453564 503013 49645025
Sopor 128.66 10.16 434 456652 19445 50128593
Hip arthroplasty 128.23 10.16 57 457029 30372 50117666
Transfusion 125.89 10.16 326 456760 12579 50135459
Death 124.06 10.16 3830 453256 321549 49826489
Shock haemorrhagic 123.98 10.16 249 456837 8095 50139943
Generalised oedema 120.96 10.16 334 456752 13397 50134641
Infection 120.52 10.16 991 456095 171963 49976075
Red blood cell sedimentation rate abnormal 119.30 10.16 7 457079 16336 50131702
Blood potassium decreased 119.19 10.16 653 456433 36292 50111746
Depressed level of consciousness 115.60 10.16 835 456251 51118 50096920
Toxic epidermal necrolysis 114.24 10.16 433 456653 20559 50127479
Asthenia 113.89 10.16 3726 453360 315316 49832722
Orthopnoea 113.81 10.16 193 456893 5496 50142542
Epistaxis 113.20 10.16 975 456111 62979 50085059
Presyncope 112.35 10.16 475 456611 23723 50124315
Cardiogenic shock 111.24 10.16 352 456734 15247 50132791
Pseudo-Bartter syndrome 110.85 10.16 35 457051 26 50148012
Drug abuse 109.07 10.16 236 456850 59610 50088428
Cardiac disorder 108.79 10.16 713 456373 42266 50105772
Subdural haematoma 107.26 10.16 308 456778 12639 50135399
Blood pressure decreased 105.13 10.16 864 456222 55045 50092993
Oliguria 104.41 10.16 230 456856 7986 50140052
Blood potassium increased 104.36 10.16 356 456730 16042 50131996
Anuria 102.53 10.16 277 456809 10967 50137071
Cardiomegaly 102.21 10.16 347 456739 15598 50132440
Loss of personal independence in daily activities 101.66 10.16 310 456776 69740 50078298
Pericardial effusion 101.25 10.16 479 456607 25110 50122928
Hypocalcaemia 100.37 10.16 494 456592 26322 50121716
Renal injury 99.35 10.16 232 456854 8379 50139659
Acute respiratory failure 99.16 10.16 518 456568 28264 50119774
Hypomagnesaemia 98.68 10.16 443 456643 22713 50125325
Cerebrovascular accident 98.59 10.16 1297 455789 93383 50054655
Hypovolaemia 98.47 10.16 245 456841 9220 50138818
Hepatic failure 98.43 10.16 562 456524 31721 50116317
C-reactive protein abnormal 97.01 10.16 66 457020 27743 50120295
Hypernatraemia 95.56 10.16 190 456896 6131 50141907
Psoriasis 95.46 10.16 312 456774 68688 50079350
Sleep disorder 95.45 10.16 237 456849 57046 50090992
Nephrocalcinosis 94.53 10.16 75 457011 899 50147139
Mitral valve incompetence 93.93 10.16 359 456727 17112 50130926
Sedation complication 91.29 10.16 227 456859 8539 50139499
Migraine 91.14 10.16 360 456726 74920 50073118
Blood calcium decreased 90.40 10.16 399 456687 20307 50127731
Multiple sclerosis relapse 89.96 10.16 156 456930 42808 50105230
Knee arthroplasty 89.79 10.16 115 456971 35731 50112307
Paraesthesia 88.80 10.16 678 456408 119565 50028473
Haematemesis 88.73 10.16 489 456597 27236 50120802
Brain natriuretic peptide increased 88.48 10.16 152 456934 4375 50143663
Atrial flutter 88.20 10.16 224 456862 8539 50139499
Bradyarrhythmia 86.87 10.16 96 456990 1794 50146244
Red blood cell sedimentation rate increased 85.00 10.16 84 457002 29332 50118706
Toxic skin eruption 84.96 10.16 259 456827 10992 50137046
Sepsis 84.60 10.16 1678 455408 131247 50016791
Acute pulmonary oedema 82.98 10.16 195 456891 7072 50140966
Blood loss anaemia 82.91 10.16 209 456877 7930 50140108
Hypochloraemia 81.54 10.16 87 456999 1560 50146478
Electrolyte imbalance 81.24 10.16 339 456747 16830 50131208
Adverse drug reaction 81.11 10.16 243 456843 54979 50093059
Blood sodium decreased 80.88 10.16 392 456694 20755 50127283
Ventricular fibrillation 80.60 10.16 244 456842 10315 50137723
Foetal exposure during pregnancy 80.36 10.16 77 457009 27282 50120756
Atrioventricular block complete 79.95 10.16 192 456894 7063 50140975
Hyperuricaemia 79.74 10.16 148 456938 4532 50143506
Cardiac arrest 79.34 10.16 1127 455959 82524 50065514
Accidental exposure to product 78.73 10.16 56 457030 23001 50125037
Gout 78.31 10.16 255 456831 11215 50136823
Nausea 77.85 10.16 5408 451678 699990 49448048
N-terminal prohormone brain natriuretic peptide increased 77.12 10.16 86 457000 1624 50146414
Lower gastrointestinal haemorrhage 76.83 10.16 183 456903 6696 50141342
Cellulitis 76.27 10.16 976 456110 69822 50078216
Cardiomyopathy 75.52 10.16 310 456776 15276 50132762
Blister 75.31 10.16 457 456629 84961 50063077
Blood bilirubin increased 74.79 10.16 521 456565 31517 50116521
Oxygen saturation decreased 73.99 10.16 998 456088 72250 50075788
Suicidal ideation 73.49 10.16 255 456831 55130 50092908
Atrioventricular block 73.07 10.16 173 456913 6305 50141733
Drug resistance 70.44 10.16 42 457044 18947 50129091
Pulmonary arterial pressure increased 68.86 10.16 115 456971 3233 50144805
Impaired work ability 68.70 10.16 19 457067 13621 50134417
Respiratory distress 68.37 10.16 491 456595 29998 50118040
Febrile neutropenia 67.79 10.16 560 456526 97107 50050931
Rheumatoid nodule 67.48 10.16 16 457070 12719 50135319
Arrhythmia 67.17 10.16 521 456565 32611 50115427
Ischaemic stroke 67.13 10.16 304 456782 15644 50132394
Confusional state 66.60 10.16 2173 454913 183755 49964283
Pruritus 66.17 10.16 2003 455083 281565 49866473
Chest pain 65.88 10.16 2077 455009 174805 49973233
Hypovolaemic shock 65.66 10.16 145 456941 5043 50142995
Blood alkaline phosphatase increased 65.29 10.16 570 456516 36956 50111082
Iron deficiency anaemia 65.06 10.16 313 456773 16521 50131517
Pemphigoid 64.74 10.16 156 456930 5751 50142287
Intentional self-injury 64.51 10.16 68 457018 23044 50124994
Hypoaesthesia 64.09 10.16 788 456298 126469 50021569
Upper gastrointestinal haemorrhage 64.05 10.16 301 456785 15734 50132304
Glomerular filtration rate decreased 63.93 10.16 241 456845 11411 50136627
Live birth 62.70 10.16 35 457051 16373 50131665
Prothrombin time prolonged 62.62 10.16 199 456887 8639 50139399
Oral herpes 62.44 10.16 57 457029 20668 50127370
Night sweats 62.33 10.16 131 456955 33443 50114595
Renal disorder 62.28 10.16 444 456642 27061 50120977
Haemodialysis 61.75 10.16 191 456895 8171 50139867
Inappropriate schedule of product administration 61.40 10.16 388 456698 71443 50076595
Shock 61.32 10.16 357 456729 20293 50127745
Intra-abdominal haematoma 61.29 10.16 73 457013 1484 50146554
Haemoptysis 60.95 10.16 418 456668 25155 50122883
No adverse event 60.69 10.16 133 456953 33445 50114593
Tenosynovitis 60.67 10.16 11 457075 10554 50137484
Prerenal failure 60.43 10.16 71 457015 1422 50146616
Joint stiffness 59.91 10.16 114 456972 30194 50117844
Left ventricular failure 59.80 10.16 134 456952 4707 50143331
Injection site warmth 58.38 10.16 26 457060 13840 50134198
Injection site rash 58.31 10.16 37 457049 16140 50131898
Cardiac output decreased 58.29 10.16 55 457031 845 50147193
Sudden death 57.92 10.16 196 456890 8795 50139243
Drug ineffective for unapproved indication 57.85 10.16 64 457022 21217 50126821
Acne 57.72 10.16 55 457031 19540 50128498
Dialysis 56.67 10.16 201 456885 9237 50138801
Anaphylactic reaction 56.59 10.16 273 456813 53782 50094256
Muscle haemorrhage 56.09 10.16 98 456988 2860 50145178
Wrong technique in product usage process 56.01 10.16 284 456802 55226 50092812
Infective pulmonary exacerbation of cystic fibrosis 55.91 10.16 4 457082 7905 50140133
Congestive hepatopathy 55.81 10.16 89 456997 2405 50145633
Muscle spasticity 55.76 10.16 44 457042 17140 50130898
Device difficult to use 55.27 10.16 11 457075 9875 50138163
Ischaemic cardiomyopathy 55.20 10.16 85 457001 2227 50145811
Balance disorder 55.02 10.16 920 456166 69670 50078368
Cor pulmonale 54.66 10.16 76 457010 1811 50146227
Injection site urticaria 54.52 10.16 21 457065 12196 50135842
Azotaemia 54.13 10.16 115 456971 3893 50144145
Cerebral haemorrhage 54.07 10.16 424 456662 26628 50121410
Aortic stenosis 53.96 10.16 118 456968 4076 50143962
Therapeutic response decreased 53.94 10.16 231 456855 47000 50101038
Basal cell carcinoma 53.41 10.16 80 457006 23276 50124762
Enthesopathy 52.75 10.16 3 457083 7190 50140848
Pulmonary congestion 52.23 10.16 274 456812 14973 50133065
Insomnia 52.13 10.16 1192 455894 173673 49974365
Hepatic function abnormal 52.05 10.16 487 456599 32194 50115844
Ovarian cyst 51.85 10.16 31 457055 13965 50134073
Abdominal wall haematoma 51.72 10.16 90 456996 2618 50145420
Plasma cell myeloma 51.52 10.16 470 456616 30852 50117186
Foot deformity 50.88 10.16 59 457027 19151 50128887
Musculoskeletal pain 50.46 10.16 413 456673 71764 50076274
Coeliac disease 49.97 10.16 9 457077 8676 50139362
Pneumonia aspiration 49.87 10.16 463 456623 30541 50117497
Pyrexia 49.64 10.16 2869 454217 377334 49770704
Rales 49.56 10.16 200 456886 9778 50138260
Gestational diabetes 49.42 10.16 5 457081 7460 50140578
Haematuria 49.31 10.16 398 456688 25215 50122823
Congestive cardiomyopathy 48.38 10.16 134 456952 5384 50142654
Concomitant disease aggravated 48.31 10.16 172 456914 7919 50140119
Oropharyngeal pain 48.30 10.16 459 456627 77342 50070696
Hepatic cirrhosis 47.80 10.16 297 456789 17280 50130758
Depression 47.53 10.16 1134 455952 164289 49983749
Bone erosion 47.52 10.16 23 457063 11664 50136374
Arteriosclerosis coronary artery 47.03 10.16 164 456922 7472 50140566
Tricuspid valve incompetence 46.89 10.16 234 456852 12536 50135502
Dilatation ventricular 46.67 10.16 79 457007 2246 50145792
Ejection fraction decreased 46.10 10.16 306 456780 18214 50129824
Progressive multifocal leukoencephalopathy 45.90 10.16 23 457063 11434 50136604
Catheter management 45.89 10.16 86 457000 2653 50145385
Psychotic disorder 45.84 10.16 79 457007 21733 50126305
Drug tolerance decreased 45.68 10.16 13 457073 9147 50138891
International normalised ratio abnormal 44.84 10.16 87 456999 2756 50145282
Mucosal inflammation 44.82 10.16 198 456888 39944 50108094
Loss of consciousness 44.69 10.16 1247 455839 103106 50044932
Nodal rhythm 44.61 10.16 63 457023 1524 50146514
Colitis ulcerative 44.39 10.16 52 457034 16802 50131236
Metabolic acidosis 44.27 10.16 541 456545 38284 50109754
Device issue 44.14 10.16 70 457016 19902 50128136
Breast cancer 44.09 10.16 218 456868 42672 50105366
Sinus node dysfunction 43.94 10.16 105 456981 3850 50144188
Cardiac pacemaker insertion 43.88 10.16 100 456986 3553 50144485
Haematotoxicity 43.69 10.16 9 457077 7886 50140152
Uterine perforation 43.25 10.16 4 457082 6411 50141627
Coagulopathy 43.18 10.16 294 456792 17650 50130388
International normalised ratio decreased 42.76 10.16 107 456979 4041 50143997
Peripartum cardiomyopathy 42.71 10.16 22 457064 114 50147924
Hyponatraemic syndrome 42.61 10.16 37 457049 507 50147531
Neutropenia 42.59 10.16 1014 456072 146951 50001087
Inflammation 42.41 10.16 320 456766 56592 50091446
Gastrointestinal tract mucosal pigmentation 42.31 10.16 38 457048 546 50147492
Aspartate aminotransferase increased 42.26 10.16 962 456124 77036 50071002
Oxygen consumption increased 41.59 10.16 96 456990 3440 50144598
Renal tubular necrosis 41.44 10.16 192 456894 9976 50138062
Aortic valve incompetence 41.29 10.16 126 456960 5350 50142688
Pharyngitis 40.95 10.16 59 457027 17444 50130594
Head injury 40.82 10.16 363 456723 23657 50124381
Fear of injection 40.63 10.16 4 457082 6099 50141939
Bone density decreased 40.37 10.16 25 457061 11050 50136988
Mood swings 40.14 10.16 51 457035 15903 50132135
Anxiety 40.03 10.16 1260 455826 176346 49971692
Immunodeficiency 39.86 10.16 45 457041 14783 50133255
Therapeutic response shortened 39.71 10.16 9 457077 7380 50140658
Adverse event 39.69 10.16 232 456854 43531 50104507
Polyuria 39.66 10.16 148 456938 6973 50141065
Coronary arterial stent insertion 39.61 10.16 79 457007 2555 50145483
Tendonitis 39.39 10.16 56 457030 16649 50131389
Dystonia 39.38 10.16 30 457056 11896 50136142
Grip strength decreased 39.37 10.16 31 457055 12090 50135948
Jugular vein distension 39.35 10.16 43 457043 793 50147245
Colitis microscopic 39.27 10.16 139 456947 6381 50141657
Ecchymosis 39.24 10.16 189 456897 9980 50138058
Influenza like illness 39.16 10.16 331 456755 57128 50090910
Maternal exposure before pregnancy 39.08 10.16 3 457083 5594 50142444
Product quality issue 38.99 10.16 145 456941 30713 50117325
Medication error 38.98 10.16 498 456588 35606 50112432
Faeces discoloured 38.69 10.16 264 456822 15860 50132178
Diabetes mellitus inadequate control 38.21 10.16 226 456860 12919 50135119
Poor venous access 38.17 10.16 23 457063 10317 50137721
Subcutaneous haematoma 38.02 10.16 57 457029 1458 50146580
Sinus bradycardia 37.91 10.16 226 456860 12957 50135081
Septic shock 37.76 10.16 726 456360 56449 50091589
Cholestasis 37.72 10.16 373 456713 25028 50123010
Blood parathyroid hormone decreased 37.57 10.16 9 457077 7105 50140933
Disability 37.46 10.16 36 457050 12739 50135299
Encephalopathy 37.25 10.16 467 456619 33244 50114794
Myoclonus 37.18 10.16 241 456845 14229 50133809
Gravitational oedema 36.90 10.16 49 457037 1116 50146922
Decreased appetite 36.89 10.16 2192 454894 198731 49949307
Arthritis 36.79 10.16 556 456530 86165 50061873
Dermatitis exfoliative 36.63 10.16 116 456970 5026 50143012
Product dose omission issue 36.56 10.16 1325 455761 182513 49965525
Concomitant disease progression 36.52 10.16 66 457020 1979 50146059
Throat irritation 36.33 10.16 145 456941 30094 50117944
Platelet count decreased 36.21 10.16 1178 455908 99548 50048490
Bundle branch block left 35.97 10.16 131 456955 6099 50141939
Ventricular arrhythmia 35.85 10.16 87 456999 3222 50144816
Disorientation 35.62 10.16 483 456603 35001 50113037
Blood uric acid increased 35.50 10.16 95 456991 3739 50144299
Hypercapnia 35.39 10.16 107 456979 4520 50143518
Hypoglycaemic coma 35.11 10.16 70 457016 2263 50145775
Dilatation atrial 34.92 10.16 61 457025 1780 50146258
Intestinal haemorrhage 34.87 10.16 84 457002 3096 50144942
Exercise tolerance decreased 34.76 10.16 110 456976 4764 50143274
Myocardial ischaemia 34.63 10.16 201 456885 11412 50136626
Angina unstable 34.58 10.16 136 456950 6570 50141468
Microcytic anaemia 34.39 10.16 82 457004 3002 50145036
Ear pain 34.38 10.16 135 456951 28148 50119890
Cardio-respiratory arrest 34.13 10.16 680 456406 53212 50094826
Jaundice 34.01 10.16 377 456709 26052 50121986
Activated partial thromboplastin time prolonged 33.96 10.16 131 456955 6271 50141767
Prothrombin time shortened 33.94 10.16 57 457029 1610 50146428
Acidosis 33.81 10.16 182 456904 10045 50137993
Device dislocation 33.70 10.16 92 456994 21454 50126584
Acute generalised exanthematous pustulosis 33.68 10.16 165 456921 8773 50139265
Oesophageal varices haemorrhage 33.67 10.16 44 457042 986 50147052
Coronary artery bypass 33.55 10.16 68 457018 2225 50145813
Type 2 diabetes mellitus 33.48 10.16 178 456908 34197 50113841
Immune reconstitution inflammatory syndrome 33.33 10.16 5 457081 5511 50142527
Unevaluable event 33.22 10.16 593 456493 45473 50102565
Inferior vena cava dilatation 33.13 10.16 15 457071 55 50147983
Hyperglycaemia 33.12 10.16 487 456599 35918 50112120
Ischaemic hepatitis 32.86 10.16 61 457025 1868 50146170
Injection site mass 32.76 10.16 57 457029 15623 50132415
Chronic respiratory failure 32.74 10.16 56 457030 1606 50146432
Eye pain 32.57 10.16 139 456947 28310 50119728
Myopathy 32.53 10.16 166 456920 8973 50139065
Acute coronary syndrome 32.48 10.16 169 456917 9205 50138833
Pneumonia viral 32.38 10.16 135 456951 6699 50141339
Menstruation irregular 32.14 10.16 8 457078 6154 50141884
Suspected suicide 32.04 10.16 5 457081 5352 50142686
Blood albumin decreased 31.93 10.16 217 456869 13019 50135019
Ventricular dysfunction 31.76 10.16 72 457014 2549 50145489
Catheter site infection 31.74 10.16 98 456988 4188 50143850
Nephrotic syndrome 31.62 10.16 105 456981 4665 50143373
Atrioventricular block first degree 31.36 10.16 125 456961 6076 50141962
Device use error 31.30 10.16 5 457081 5261 50142777
Uveitis 31.28 10.16 23 457063 9287 50138751
Panniculitis 31.27 10.16 19 457067 8484 50139554
Cerebral haematoma 31.20 10.16 81 457005 3130 50144908
Pain in extremity 30.86 10.16 2086 455000 270779 49877259
Cognitive disorder 30.77 10.16 565 456521 43558 50104480
Alkalosis hypochloraemic 30.71 10.16 18 457068 125 50147913
Haemorrhage subcutaneous 30.32 10.16 72 457014 2629 50145409
Bradyphrenia 30.31 10.16 123 456963 6029 50142009
Blood cholesterol increased 30.05 10.16 336 456750 54879 50093159
Haemorrhage 29.84 10.16 662 456424 52779 50095259
Metastases to bone 29.54 10.16 75 457011 17920 50130118
Scleroderma 29.47 10.16 103 456983 4698 50143340
Nasal congestion 29.42 10.16 636 456450 50484 50097554
Lethargy 29.42 10.16 618 456468 48814 50099224
Liver function test increased 29.38 10.16 125 456961 25481 50122557
Nodule 29.38 10.16 69 457017 16934 50131104
Cardiac valve disease 29.38 10.16 88 456998 3698 50144340
Bursitis 29.30 10.16 102 456984 22033 50126005
Ankylosing spondylitis 29.29 10.16 14 457072 7151 50140887
Nephrogenic anaemia 29.15 10.16 54 457032 1651 50146387
Petechiae 28.92 10.16 203 456883 12309 50135729
Tachypnoea 28.87 10.16 228 456858 14349 50133689
Seizure 28.82 10.16 827 456259 117047 50030991
Multiple sclerosis 28.79 10.16 92 456994 20401 50127637
Mental status changes 28.72 10.16 474 456612 35798 50112240
Renal artery stenosis 28.64 10.16 53 457033 1619 50146419
Amenorrhoea 28.45 10.16 21 457065 8463 50139575
Electrocardiogram ST segment abnormal 28.30 10.16 38 457048 875 50147163
Pre-eclampsia 28.18 10.16 19 457067 8025 50140013
Dry eye 28.12 10.16 172 456914 31923 50116115
Pelvic pain 28.05 10.16 36 457050 11177 50136861
Oxygen therapy 28.03 10.16 55 457031 1757 50146281
Osteoarthritis 28.03 10.16 443 456643 68163 50079875
Hypercreatininaemia 28.02 10.16 25 457061 356 50147682
Complication of device insertion 27.60 10.16 10 457076 6031 50142007
Central nervous system lesion 27.52 10.16 27 457059 9462 50138576
Neck pain 27.35 10.16 357 456729 56710 50091328
Ear infection 27.27 10.16 131 456955 25839 50122199
Venous pressure jugular increased 27.18 10.16 29 457057 520 50147518
Cyanosis 27.12 10.16 232 456854 14952 50133086
Bundle branch block right 27.10 10.16 98 456988 4547 50143491
Retroperitoneal haematoma 27.06 10.16 68 457018 2575 50145463
Occult blood positive 26.98 10.16 78 457008 3213 50144825
Osteoporosis 26.90 10.16 267 456819 44612 50103426
Dermatitis bullous 26.73 10.16 132 456954 7041 50140997
Vascular purpura 26.72 10.16 43 457043 1171 50146867
Blood chloride decreased 26.71 10.16 102 456984 4859 50143179
Basilar artery occlusion 26.71 10.16 15 457071 95 50147943
Paracentesis 26.70 10.16 37 457049 879 50147159
Irritability 26.69 10.16 149 456937 28277 50119761
Lupus-like syndrome 26.40 10.16 28 457058 9463 50138575
Soft tissue disorder 26.38 10.16 91 456995 4123 50143915
Fear 26.35 10.16 223 456863 14326 50133712
Pregnancy with contraceptive device 26.32 10.16 3 457083 4076 50143962
Ventricular hypertrophy 26.16 10.16 76 457010 3139 50144899
Burning sensation 26.16 10.16 273 456813 45173 50102865
Right atrial dilatation 26.15 10.16 30 457056 585 50147453
Sedation 26.11 10.16 405 456681 30205 50117833
Incorrect route of product administration 26.08 10.16 84 457002 18582 50129456
Impaired quality of life 26.06 10.16 11 457075 6045 50141993
Heparin-induced thrombocytopenia 26.04 10.16 87 456999 3878 50144160
Anhedonia 25.94 10.16 161 456925 9363 50138675
Product storage error 25.94 10.16 44 457042 12180 50135858
Pallor 25.90 10.16 322 456764 22877 50125161
Protein total decreased 25.82 10.16 105 456981 5151 50142887
Blood creatinine abnormal 25.77 10.16 67 457019 2591 50145447
Drug reaction with eosinophilia and systemic symptoms 25.76 10.16 380 456706 28044 50119994
Abdominal cavity drainage 25.68 10.16 24 457062 364 50147674
Sinus arrest 25.62 10.16 51 457035 1647 50146391
Circulatory collapse 25.60 10.16 285 456801 19715 50128323
Disease recurrence 25.60 10.16 94 456992 19987 50128051
Premature labour 25.57 10.16 40 457046 11436 50136602
Gastritis erosive 25.57 10.16 103 456983 5031 50143007
Neuropathy peripheral 25.42 10.16 672 456414 96085 50051953
Stillbirth 25.31 10.16 11 457075 5941 50142097
Extrasystoles 25.31 10.16 96 456990 4559 50143479
Injection site haemorrhage 25.24 10.16 103 456983 21243 50126795
Catheter site erythema 25.19 10.16 86 457000 3876 50144162
Toxicity to various agents 25.11 10.16 1618 455468 210881 49937157
Decubitus ulcer 24.90 10.16 158 456928 9260 50138778
Nephrosclerosis 24.85 10.16 36 457050 892 50147146
Upper respiratory tract infection 24.79 10.16 432 456654 65466 50082572
Tooth infection 24.60 10.16 57 457029 14055 50133983
Heavy menstrual bleeding 24.55 10.16 66 457020 15471 50132567
Hypophagia 24.47 10.16 369 456717 27359 50120679
Pulmonary alveolar haemorrhage 24.38 10.16 86 457000 3941 50144097
Blood creatine increased 24.31 10.16 98 456988 4789 50143249
Musculoskeletal disorder 24.29 10.16 78 457008 17271 50130767
Hyperglycaemic hyperosmolar nonketotic syndrome 24.29 10.16 29 457057 591 50147447
Tachyarrhythmia 24.28 10.16 87 456999 4018 50144020
Malignant neoplasm progression 24.24 10.16 451 456635 67673 50080365
Haemorrhage intracranial 24.21 10.16 193 456893 12181 50135857
Metabolic encephalopathy 24.13 10.16 101 456985 5020 50143018
Hypoxic-ischaemic encephalopathy 24.08 10.16 83 457003 3759 50144279
Hyperaesthesia 24.00 10.16 23 457063 8150 50139888
Aspiration pleural cavity 23.96 10.16 32 457054 733 50147305
Body temperature increased 23.93 10.16 175 456911 31166 50116872
Atrial enlargement 23.77 10.16 21 457065 295 50147743
Anticoagulation drug level above therapeutic 23.76 10.16 40 457046 1132 50146906
Disseminated intravascular coagulation 23.71 10.16 248 456838 16887 50131151
Nodal arrhythmia 23.64 10.16 39 457047 1085 50146953
Brain natriuretic peptide 23.57 10.16 10 457076 30 50148008
Ulcer 23.55 10.16 98 456988 20102 50127936
Joint range of motion decreased 23.38 10.16 87 456999 18425 50129613
Intentional product misuse 23.27 10.16 290 456796 46444 50101594
Eosinophilia 23.07 10.16 264 456822 18388 50129650
Temperature regulation disorder 23.02 10.16 5 457081 4222 50143816
Agranulocytosis 22.92 10.16 295 456791 21126 50126912
Angina pectoris 22.91 10.16 348 456738 25840 50122198
Mixed liver injury 22.91 10.16 76 457010 3375 50144663
Exposure to toxic agent 22.84 10.16 3 457083 3655 50144383
Haemorrhoidal haemorrhage 22.80 10.16 79 457007 3588 50144450
Catheter placement 22.77 10.16 54 457032 1970 50146068
Visual impairment 22.76 10.16 457 456629 67818 50080220
Cardiac operation 22.67 10.16 66 457020 2729 50145309
Hypercalciuria 22.67 10.16 18 457068 216 50147822
Cardiac murmur 22.65 10.16 171 456915 10613 50137425
Crying 22.61 10.16 101 456985 20315 50127723
Therapy partial responder 22.51 10.16 16 457070 6575 50141463
Hepatojugular reflux 22.51 10.16 8 457078 12 50148026
Walking distance test abnormal 22.47 10.16 26 457060 512 50147526
Tetany 22.46 10.16 47 457039 1574 50146464
Duodenal ulcer haemorrhage 22.46 10.16 56 457030 2110 50145928
Haemorrhagic disorder 22.38 10.16 31 457055 736 50147302
Interstitial lung disease 22.35 10.16 634 456452 52542 50095496
Catheter site pruritus 22.34 10.16 53 457033 1934 50146104
Pericardial haemorrhage 22.25 10.16 44 457042 1414 50146624
Photophobia 22.22 10.16 65 457021 14822 50133216
Carbon dioxide increased 22.19 10.16 38 457048 1091 50146947
Caesarean section 22.12 10.16 70 457016 15569 50132469
Haematoma muscle 22.11 10.16 30 457056 698 50147340
Nightmare 22.05 10.16 73 457013 16013 50132025
Peritonitis bacterial 22.02 10.16 92 456994 4569 50143469
Arteriosclerosis 22.00 10.16 149 456937 8928 50139110
Haemorrhagic diathesis 21.94 10.16 82 457004 3866 50144172
Liver function test abnormal 21.91 10.16 540 456546 43799 50104239
Poisoning 21.83 10.16 50 457036 12379 50135659
Malignant melanoma 21.80 10.16 36 457050 10072 50137966
Drug level increased 21.75 10.16 268 456818 19000 50129038
Blood glucose decreased 21.74 10.16 256 456830 17955 50130083
Synovial cyst 21.71 10.16 25 457061 8141 50139897
Hepatitis fulminant 21.66 10.16 69 457017 2999 50145039
Hypoalbuminaemia 21.65 10.16 158 456928 9702 50138336
Gouty arthritis 21.50 10.16 25 457061 495 50147543
Pickwickian syndrome 21.50 10.16 19 457067 267 50147771
Foetal growth restriction 21.46 10.16 17 457069 6610 50141428
Pain in jaw 21.44 10.16 476 456610 37952 50110086
Troponin increased 21.34 10.16 136 456950 7982 50140056
Lung transplant 21.30 10.16 65 457021 2760 50145278
Volume blood decreased 21.30 10.16 14 457072 122 50147916
Abdominal pain upper 21.28 10.16 1199 455887 158110 49989928
Cholecystitis chronic 21.26 10.16 34 457052 9635 50138403
Ureteric rupture 21.22 10.16 7 457079 7 50148031
Catheter site discharge 21.19 10.16 50 457036 1818 50146220
Atrial septal defect repair 21.14 10.16 17 457069 208 50147830
Blood pressure inadequately controlled 21.12 10.16 87 456999 4293 50143745
Galactorrhoea 21.11 10.16 4 457082 3719 50144319
Blood pressure fluctuation 21.11 10.16 214 456872 35609 50112429
Vascular device infection 21.08 10.16 87 456999 4297 50143741
Hepatocellular carcinoma 21.06 10.16 52 457034 1947 50146091
Adverse reaction 21.03 10.16 28 457058 8558 50139480
Cardiac cirrhosis 21.02 10.16 14 457072 125 50147913
Wrong patient received product 20.94 10.16 47 457039 1653 50146385
Catheterisation cardiac 20.89 10.16 82 457004 3958 50144080
Serotonin syndrome 20.85 10.16 134 456952 24579 50123459
Asthma 20.78 10.16 631 456455 88706 50059332
Abdominal distension 20.65 10.16 830 456256 72073 50075965
Complication of device removal 20.60 10.16 6 457080 4158 50143880
Ventricular extrasystoles 20.56 10.16 164 456922 10352 50137686
Nephrolithiasis 20.54 10.16 207 456879 34486 50113552
Change of bowel habit 20.51 10.16 48 457038 1736 50146302
Hyperprolactinaemia 20.45 10.16 3 457083 3362 50144676
Haematocrit decreased 20.40 10.16 436 456650 34540 50113498
Cardiac hypertrophy 20.38 10.16 34 457052 955 50147083
Pharyngitis streptococcal 20.30 10.16 30 457056 8778 50139260
Polyarthritis 20.30 10.16 25 457061 7902 50140136
Maternal exposure timing unspecified 20.29 10.16 4 457082 3616 50144422
Gastric disorder 20.22 10.16 170 456916 29378 50118660
Mydriasis 20.11 10.16 41 457045 10586 50137452
Demyelination 20.10 10.16 15 457071 6011 50142027
Hepatorenal failure 20.09 10.16 26 457060 577 50147461
Urosepsis 20.08 10.16 221 456865 15244 50132794
Diastolic dysfunction 20.07 10.16 98 456988 5204 50142834
Multiple drug therapy 20 10.16 50 457036 1887 50146151
Transient ischaemic attack 19.92 10.16 405 456681 31805 50116233
Hypochromic anaemia 19.90 10.16 46 457040 1650 50146388
Altered state of consciousness 19.89 10.16 293 456793 21617 50126421
Sexual dysfunction 19.85 10.16 3 457083 3289 50144749
COVID-19 19.84 10.16 299 456787 46363 50101675
Hyperamylasaemia 19.77 10.16 20 457066 336 50147702
Mitral valve stenosis 19.76 10.16 34 457052 980 50147058
Dyspnoea at rest 19.65 10.16 75 457011 3572 50144466
Mood altered 19.63 10.16 55 457031 12718 50135320
Dyspnoea paroxysmal nocturnal 19.62 10.16 30 457056 781 50147257
Bone pain 19.61 10.16 304 456782 46925 50101113
Lymphocyte count decreased 19.56 10.16 148 456938 26159 50121879
Blood urea abnormal 19.48 10.16 25 457061 550 50147488
Ovarian hyperstimulation syndrome 19.47 10.16 3 457083 3241 50144797
Hepatotoxicity 19.38 10.16 155 456931 27071 50120967
Skin turgor decreased 19.37 10.16 23 457063 466 50147572
Lymphoedema 19.36 10.16 145 456941 8977 50139061
Erythromelalgia 19.34 10.16 13 457073 118 50147920
Device deployment issue 19.31 10.16 4 457082 3492 50144546
Renal atrophy 19.30 10.16 38 457048 1217 50146821
Schizophrenia 19.29 10.16 23 457063 7374 50140664
Continuous haemodiafiltration 19.23 10.16 33 457053 949 50147089
Drug withdrawal syndrome 19.17 10.16 140 456946 24941 50123097
Hot flush 19.13 10.16 282 456804 43887 50104151
Glomerulonephritis acute 19.10 10.16 9 457077 37 50148001
Hepatorenal syndrome 19.07 10.16 46 457040 1697 50146341
Nephropathy 19.06 10.16 96 456990 5162 50142876
Hypocoagulable state 19.05 10.16 32 457054 904 50147134
Tuberculosis 19.00 10.16 39 457047 10044 50137994
Malaise 18.99 10.16 3375 453711 332157 49815881
Right ventricular enlargement 18.95 10.16 18 457068 279 50147759
Gouty tophus 18.93 10.16 14 457072 150 50147888
Fungal infection 18.92 10.16 176 456910 29789 50118249
Right ventricular dysfunction 18.92 10.16 43 457043 1525 50146513
Neutrophil count decreased 18.86 10.16 297 456789 45729 50102309
Fibromyalgia 18.85 10.16 289 456797 44689 50103349
Mouth ulceration 18.84 10.16 162 456924 27862 50120176
Catheter site haemorrhage 18.76 10.16 62 457024 2748 50145290
Ocular hyperaemia 18.70 10.16 107 456979 20185 50127853
Therapeutic embolisation 18.70 10.16 14 457072 153 50147885
Hypertrophic cardiomyopathy 18.64 10.16 39 457047 1306 50146732
Gastric haemorrhage 18.58 10.16 101 456985 5595 50142443
Skin weeping 18.57 10.16 21 457065 403 50147635
Right ventricular dilatation 18.55 10.16 32 457054 924 50147114
Affect lability 18.53 10.16 33 457053 8965 50139073
Paradoxical drug reaction 18.52 10.16 5 457081 3642 50144396
Tracheostomy 18.43 10.16 24 457062 536 50147502
Respiratory acidosis 18.41 10.16 105 456981 5923 50142115
Optic ischaemic neuropathy 18.39 10.16 33 457053 984 50147054
Catheter site pain 18.36 10.16 75 457011 3687 50144351
Device related infection 18.32 10.16 276 456810 20459 50127579
Staphylococcus test positive 18.32 10.16 70 457016 3336 50144702
Peripheral embolism 18.27 10.16 35 457051 1098 50146940
Eye irritation 18.26 10.16 86 457000 17054 50130984
Asterixis 18.24 10.16 36 457050 1155 50146883
Liver injury 18.23 10.16 140 456946 24666 50123372
Depressed mood 18.13 10.16 208 456878 33815 50114223
Thrombocytopenia 18.07 10.16 1363 455723 126310 50021728
Metastases to liver 18 10.16 107 456979 19997 50128041
Hospitalisation 17.99 10.16 768 456318 67169 50080869
Low cardiac output syndrome 17.97 10.16 17 457069 262 50147776
Marasmus 17.93 10.16 21 457065 419 50147619
Atrial tachycardia 17.93 10.16 51 457035 2081 50145957
Carpal tunnel syndrome 17.86 10.16 85 457001 16808 50131230
Sight disability 17.76 10.16 12 457074 110 50147928
Cerebral infarction 17.72 10.16 284 456802 21320 50126718
Internal haemorrhage 17.70 10.16 83 457003 4334 50143704
Mucosal dryness 17.65 10.16 55 457031 2362 50145676
Spontaneous haematoma 17.52 10.16 28 457058 758 50147280
Acute motor-sensory axonal neuropathy 17.51 10.16 17 457069 271 50147767
Bilirubin conjugated increased 17.45 10.16 55 457031 2377 50145661
Traumatic haematoma 17.45 10.16 38 457048 1309 50146729
Emotional disorder 17.43 10.16 52 457034 11784 50136254
Small for dates baby 17.43 10.16 5 457081 3500 50144538
Pulmonary hypoplasia 17.41 10.16 17 457069 273 50147765
Diabetic hyperosmolar coma 17.40 10.16 19 457067 350 50147688
Staphylococcal sepsis 17.36 10.16 116 456970 6920 50141118
Vital capacity decreased 17.26 10.16 31 457055 925 50147113
Scleritis 17.20 10.16 4 457082 3223 50144815
Gamma-glutamyltransferase increased 17.19 10.16 369 456717 29254 50118784
Product preparation error 17.18 10.16 9 457077 4363 50143675
Hypothermia 17.14 10.16 175 456911 11841 50136197
Hypokalaemic syndrome 17.12 10.16 9 457077 49 50147989
Injection site induration 17.11 10.16 31 457055 8366 50139672
Nail disorder 17.09 10.16 39 457047 9669 50138369
Condition aggravated 17.08 10.16 2387 454699 294671 49853367
Stress 17.06 10.16 363 456723 53430 50094608
Rectosigmoid cancer 17.00 10.16 13 457073 147 50147891
Mitral valve disease 16.97 10.16 49 457037 2017 50146021
Endocarditis 16.96 10.16 91 456995 5016 50143022
Substance abuse 16.95 10.16 8 457078 4116 50143922
Blood sodium increased 16.94 10.16 54 457032 2348 50145690
Subdural haemorrhage 16.90 10.16 59 457027 2690 50145348
Neutropenic sepsis 16.89 10.16 68 457018 14079 50133959
Electrocardiogram repolarisation abnormality 16.87 10.16 35 457051 1165 50146873
Cardioversion 16.81 10.16 34 457052 1111 50146927
Prothrombin level decreased 16.74 10.16 22 457064 496 50147542
Disturbance in social behaviour 16.65 10.16 3 457083 2891 50145147
Gastric varices 16.58 10.16 13 457073 153 50147885
Joint effusion 16.57 10.16 61 457025 12960 50135078
Anger 16.54 10.16 50 457036 11283 50136755
Tooth abscess 16.52 10.16 60 457026 12800 50135238
Drug monitoring procedure not performed 16.50 10.16 21 457065 458 50147580
Urinary tract discomfort 16.45 10.16 15 457071 220 50147818
Left ventricular dysfunction 16.45 10.16 156 456930 10350 50137688
Illness 16.43 10.16 142 456944 24398 50123640
Product complaint 16.36 10.16 167 456919 11299 50136739
Bleeding varicose vein 16.35 10.16 15 457071 222 50147816
Optic neuritis 16.34 10.16 23 457063 6867 50141171
Platelet transfusion 16.29 10.16 25 457061 653 50147385
Hyperaldosteronism 16.29 10.16 15 457071 223 50147815
Cardiopulmonary failure 16.27 10.16 67 457019 3306 50144732
Cardiac rehabilitation therapy 16.26 10.16 5 457081 3 50148035
Cardiac amyloidosis 16.24 10.16 26 457060 705 50147333
Anal abscess 16.13 10.16 7 457079 3784 50144254
Muscle twitching 16.11 10.16 78 457008 15353 50132685
Peripheral arterial occlusive disease 16.08 10.16 69 457017 3468 50144570
Thalamic infarction 16.04 10.16 20 457066 427 50147611
Pseudoporphyria 16.04 10.16 13 457073 161 50147877
Urine odour abnormal 16.02 10.16 93 456993 5280 50142758
Cerebral venous thrombosis 15.97 10.16 45 457041 1826 50146212
Dysmenorrhoea 15.96 10.16 5 457081 3305 50144733
Cushingoid 15.94 10.16 22 457064 6623 50141415
Gastrointestinal angiodysplasia 15.89 10.16 19 457067 388 50147650
Postpericardiotomy syndrome 15.81 10.16 6 457080 12 50148026
Alkalosis 15.81 10.16 16 457070 269 50147769
Middle insomnia 15.79 10.16 42 457044 9879 50138159
Back pain 15.75 10.16 1743 455343 218287 49929751
BRASH syndrome 15.71 10.16 14 457072 199 50147839
Fryns syndrome 15.65 10.16 9 457077 60 50147978
Intestinal pseudo-obstruction 15.64 10.16 26 457060 728 50147310
Electrocardiogram U wave present 15.61 10.16 10 457076 83 50147955
Blood glucose increased 15.60 10.16 791 456295 70533 50077505
Nephropathy toxic 15.58 10.16 125 456961 7904 50140134
Pulmonary veno-occlusive disease 15.58 10.16 30 457056 945 50147093
Blood iron decreased 15.55 10.16 167 456919 11448 50136590
Genital haemorrhage 15.54 10.16 22 457064 6552 50141486
Bundle branch block 15.52 10.16 27 457059 785 50147253
Wound secretion 15.50 10.16 72 457014 3745 50144293
Blood creatine phosphokinase increased 15.48 10.16 329 456757 26038 50122000
Clostridial sepsis 15.45 10.16 18 457068 357 50147681
Tongue disorder 15.45 10.16 38 457048 9178 50138860
Pancytopenia 15.44 10.16 917 456169 83113 50064925
Disturbance in attention 15.35 10.16 194 456892 30992 50117046
Thermohypoaesthesia 15.33 10.16 11 457075 112 50147926
Abortion induced 15.29 10.16 39 457047 9305 50138733
Cerebral mass effect 15.28 10.16 27 457059 795 50147243
Deafness neurosensory 15.28 10.16 11 457075 4490 50143548
Vitamin B1 deficiency 15.26 10.16 16 457070 281 50147757
Breast pain 15.24 10.16 28 457058 7516 50140522
Vascular graft 15.22 10.16 26 457060 745 50147293
Infective exacerbation of chronic obstructive airways disease 15.20 10.16 32 457054 1076 50146962
Coagulation time prolonged 15.18 10.16 33 457053 1135 50146903
Antibiotic level above therapeutic 15.16 10.16 15 457071 245 50147793
Heart valve incompetence 15.07 10.16 51 457035 2288 50145750
Ammonia increased 15.07 10.16 77 457009 4164 50143874
Nasal mucosal erosion 15.07 10.16 9 457077 65 50147973
Cataract 15.05 10.16 319 456767 46981 50101057
End stage renal disease 15.01 10.16 96 456990 5641 50142397
Transplant evaluation 15.00 10.16 31 457055 1029 50147009
Limb reduction defect 15.00 10.16 18 457068 369 50147669
Retroperitoneal haemorrhage 14.97 10.16 54 457032 2502 50145536
Brain natriuretic peptide abnormal 14.96 10.16 17 457069 328 50147710
Gastric ulcer haemorrhage 14.96 10.16 80 457006 4404 50143634
Blood potassium abnormal 14.94 10.16 49 457037 2163 50145875
Arteriospasm coronary 14.93 10.16 6 457080 3396 50144642
Puncture site haemorrhage 14.92 10.16 15 457071 250 50147788
Electrocardiogram ST-T segment depression 14.86 10.16 4 457082 0 50148038
Electrocardiogram QT shortened 14.86 10.16 11 457075 118 50147920
Ulcer haemorrhage 14.85 10.16 65 457021 3296 50144742
Spinal pain 14.83 10.16 49 457037 10754 50137284
Frequent bowel movements 14.73 10.16 70 457016 13848 50134190
Peripheral sensory neuropathy 14.66 10.16 23 457063 6568 50141470
Transcription medication error 14.63 10.16 13 457073 184 50147854
Lip dry 14.62 10.16 13 457073 4774 50143264
Lymphorrhoea 14.59 10.16 8 457078 48 50147990
Device pacing issue 14.53 10.16 9 457077 70 50147968
Streptococcal sepsis 14.52 10.16 41 457045 1666 50146372
Surgery 14.45 10.16 189 456897 30016 50118022
Purpura 14.45 10.16 145 456941 9766 50138272
Paraesthesia oral 14.43 10.16 59 457027 12162 50135876
Systemic scleroderma 14.43 10.16 27 457059 832 50147206
Platelet dysfunction 14.42 10.16 10 457076 96 50147942
Menstrual disorder 14.42 10.16 11 457075 4359 50143679
Catheter removal 14.37 10.16 17 457069 343 50147695
Extradural haematoma 14.37 10.16 39 457047 1548 50146490
Generalised tonic-clonic seizure 14.35 10.16 160 456926 26150 50121888
Localised oedema 14.35 10.16 84 457002 4783 50143255
Embolic stroke 14.35 10.16 66 457020 3418 50144620
Skin graft failure 14.33 10.16 10 457076 97 50147941
Superinfection 14.30 10.16 46 457040 2010 50146028
Multiple-drug resistance 14.29 10.16 6 457080 3308 50144730
Supraventricular extrasystoles 14.29 10.16 72 457014 3872 50144166
Diabetic nephropathy 14.29 10.16 35 457051 1304 50146734
Blood aldosterone increased 14.27 10.16 12 457074 157 50147881
Throat tightness 14.24 10.16 120 456966 20727 50127311
Maternal drugs affecting foetus 14.10 10.16 15 457071 5062 50142976
Gastric varices haemorrhage 14.08 10.16 10 457076 100 50147938
Pulmonary arterial pressure abnormal 14.07 10.16 19 457067 440 50147598
Palpitations 14.06 10.16 1013 456073 93493 50054545
Joint destruction 14.05 10.16 9 457077 3907 50144131
Haemorrhagic stroke 14.00 10.16 88 456998 5140 50142898
Supraventricular tachycardia 14.00 10.16 177 456909 12624 50135414
Acute respiratory distress syndrome 13.95 10.16 268 456818 20831 50127207
Urinary tract infection 13.94 10.16 2265 454821 221755 49926283
Tunnel vision 13.87 10.16 24 457062 695 50147343
Normochromic normocytic anaemia 13.85 10.16 74 457012 4072 50143966
Tongue oedema 13.85 10.16 70 457016 3769 50144269
Pulmonary vein stenosis 13.83 10.16 9 457077 77 50147961
Product prescribing error 13.78 10.16 266 456820 20695 50127343
Dementia 13.77 10.16 212 456874 15785 50132253
Respiratory alkalosis 13.74 10.16 52 457034 2467 50145571
Mechanical ventilation 13.73 10.16 32 457054 1154 50146884
Heart transplant 13.72 10.16 18 457068 405 50147633
Rash pruritic 13.72 10.16 328 456758 47518 50100520
Hypoproteinaemia 13.68 10.16 42 457044 1789 50146249
Pericardial excision 13.68 10.16 6 457080 20 50148018
Second primary malignancy 13.67 10.16 26 457060 6888 50141150
Hypermagnesaemia 13.67 10.16 27 457059 867 50147171
Tubulointerstitial nephritis 13.64 10.16 203 456883 15008 50133030
Femur fracture 13.64 10.16 247 456839 37217 50110821
Blood pressure increased 13.51 10.16 1027 456059 132105 50015933
Haemodynamic instability 13.50 10.16 121 456965 7903 50140135
Hyperbilirubinaemia 13.47 10.16 139 456947 9431 50138607
Reversible airways obstruction 13.47 10.16 29 457057 991 50147047
Stasis dermatitis 13.47 10.16 22 457064 607 50147431
Finger deformity 13.44 10.16 19 457067 5663 50142375
Bronchitis 13.43 10.16 1104 455982 103055 50044983
Multimorbidity 13.41 10.16 20 457066 509 50147529
Haemophagocytic lymphohistiocytosis 13.40 10.16 37 457049 8596 50139442
Angiopathy 13.38 10.16 73 457013 4049 50143989
International normalised ratio 13.36 10.16 9 457077 82 50147956
Premature rupture of membranes 13.32 10.16 13 457073 4567 50143471
Food allergy 13.29 10.16 34 457052 8103 50139935
Blepharospasm 13.27 10.16 5 457081 2943 50145095
Cardiothoracic ratio increased 13.25 10.16 6 457080 22 50148016
Intervertebral disc protrusion 13.21 10.16 119 456967 20274 50127764
Myocardial necrosis 13.20 10.16 11 457075 142 50147896
Cardiac valve replacement complication 13.20 10.16 11 457075 142 50147896
Rheumatic heart disease 13.18 10.16 5 457081 10 50148028
Blood lactate dehydrogenase increased 13.12 10.16 249 456837 19313 50128725
Deformity 13.10 10.16 33 457053 7907 50140131
Ataxia 13.08 10.16 72 457014 13714 50134324
Joint dislocation 13.07 10.16 62 457024 12271 50135767
Feeling abnormal 13.07 10.16 966 456120 124526 50023512
Sputum culture positive 13.06 10.16 35 457051 1379 50146659
Amyloidosis 13.04 10.16 28 457058 955 50147083
Neuroleptic malignant syndrome 12.97 10.16 54 457032 11076 50136962
Dyspepsia 12.97 10.16 542 456544 73555 50074483
Alveolar osteitis 12.94 10.16 18 457068 429 50147609
Prothrombin time abnormal 12.94 10.16 17 457069 383 50147655
Haemoconcentration 12.94 10.16 8 457078 62 50147976
Bradykinesia 12.92 10.16 70 457016 3873 50144165
Laryngitis 12.87 10.16 53 457033 10903 50137135
Blood iron abnormal 12.85 10.16 7 457079 3319 50144719
Hiatus hernia 12.82 10.16 235 456851 18109 50129929
Onychomycosis 12.81 10.16 16 457070 5026 50143012
Pulmonary hypertensive crisis 12.79 10.16 12 457074 183 50147855
Gastrointestinal toxicity 12.78 10.16 14 457072 4663 50143375
Blood prolactin increased 12.75 10.16 6 457080 3093 50144945
Limb hypoplasia congenital 12.74 10.16 12 457074 184 50147854
Lip erosion 12.73 10.16 25 457061 799 50147239
Joint laxity 12.73 10.16 3 457083 2395 50145643
Neuralgia 12.72 10.16 131 456955 21732 50126306
Urine sodium decreased 12.71 10.16 11 457075 150 50147888
Mania 12.70 10.16 53 457033 10863 50137175
Mental disorder 12.70 10.16 132 456954 21859 50126179
Macular degeneration 12.66 10.16 77 457009 14311 50133727
Nephritis allergic 12.65 10.16 11 457075 151 50147887
Blood antidiuretic hormone increased 12.65 10.16 4 457082 3 50148035
Vitamin B1 decreased 12.64 10.16 7 457079 43 50147995
Hypoprothrombinaemia 12.61 10.16 14 457072 263 50147775
Congenital nail disorder 12.59 10.16 9 457077 91 50147947
Ischaemia 12.57 10.16 74 457012 4223 50143815
Coronary artery occlusion 12.55 10.16 113 456973 7390 50140648
Asphyxia 12.51 10.16 88 456998 5339 50142699
Hypertensive heart disease 12.49 10.16 47 457039 2223 50145815
Sciatica 12.48 10.16 128 456958 21254 50126784
Toxic encephalopathy 12.47 10.16 89 456997 5426 50142612
Incorrect dose administered by device 12.45 10.16 8 457078 3467 50144571
Human herpesvirus 6 infection 12.45 10.16 4 457082 2602 50145436
Drug therapeutic incompatibility 12.38 10.16 7 457079 45 50147993
Erythema 12.37 10.16 1146 455940 145268 50002770
Bone density abnormal 12.37 10.16 6 457080 3039 50144999
Hyperthyroidism 12.33 10.16 166 456920 12009 50136029
Dermatitis allergic 12.31 10.16 66 457020 12654 50135384
Ventricular septal defect 12.31 10.16 11 457075 4030 50144008
Osteonecrosis of jaw 12.30 10.16 213 456873 32313 50115725
Chronic left ventricular failure 12.29 10.16 15 457071 313 50147725
Infection susceptibility increased 12.29 10.16 4 457082 2580 50145458
Inflammatory bowel disease 12.28 10.16 8 457078 3442 50144596
Cleft palate 12.28 10.16 27 457059 936 50147102
Hepatic steatosis 12.25 10.16 151 456935 24233 50123805
Diabetes mellitus 12.25 10.16 551 456535 48482 50099556
Craniocerebral injury 12.24 10.16 46 457040 2175 50145863
Apnoea 12.21 10.16 106 456980 6860 50141178
Poisoning deliberate 12.21 10.16 34 457052 7878 50140160
Paranoia 12.19 10.16 50 457036 10298 50137740
Post transplant lymphoproliferative disorder 12.15 10.16 12 457074 4192 50143846
Adrenal insufficiency 12.13 10.16 77 457009 14166 50133872
Lung infiltration 12.11 10.16 179 456907 13214 50134824
Long QT syndrome 12.07 10.16 56 457030 2911 50145127
Cardiorenal syndrome 12.06 10.16 20 457066 559 50147479
Blood pH increased 12.03 10.16 19 457067 509 50147529
Mucosal erosion 12.03 10.16 32 457054 1255 50146783
Left ventricular hypertrophy 12.02 10.16 80 457006 4765 50143273
Sickle cell anaemia with crisis 11.98 10.16 14 457072 4529 50143509
Biopsy liver 11.96 10.16 16 457070 367 50147671
Cyanosis central 11.96 10.16 8 457078 72 50147966
Clostridium difficile colitis 11.95 10.16 226 456860 17516 50130522
Blood culture negative 11.94 10.16 10 457076 130 50147908
Cyst 11.92 10.16 63 457023 12124 50135914
Sleep disorder due to a general medical condition 11.88 10.16 31 457055 7340 50140698
Tuberculin test positive 11.88 10.16 7 457079 3179 50144859
Diabetic foot infection 11.87 10.16 11 457075 165 50147873
Brain compression 11.86 10.16 15 457071 325 50147713
Alanine aminotransferase abnormal 11.85 10.16 12 457074 4144 50143894
Vaginal infection 11.85 10.16 24 457062 6212 50141826
Haemorrhagic transformation stroke 11.85 10.16 29 457057 1080 50146958
Fracture delayed union 11.78 10.16 3 457083 2273 50145765
Catheter site rash 11.78 10.16 23 457063 732 50147306
Chills 11.78 10.16 734 456352 95953 50052085
Anal fistula 11.77 10.16 5 457081 2737 50145301
Transplant dysfunction 11.76 10.16 15 457071 4669 50143369
Drug specific antibody present 11.74 10.16 8 457078 3360 50144678
Mouth breathing 11.66 10.16 6 457080 31 50148007
Right atrial pressure increased 11.64 10.16 10 457076 135 50147903
Vaginal haemorrhage 11.61 10.16 154 456932 24397 50123641
Affective disorder 11.60 10.16 18 457068 5163 50142875
Pulmonary artery dilatation 11.59 10.16 13 457073 247 50147791
Dysaesthesia 11.58 10.16 10 457076 3725 50144313
Myelosuppression 11.55 10.16 73 457013 13444 50134594
Mucormycosis 11.53 10.16 4 457082 2479 50145559
Lymphadenopathy 11.53 10.16 223 456863 33276 50114762
Fine motor skill dysfunction 11.53 10.16 12 457074 4091 50143947
Pulmonary haemorrhage 11.49 10.16 99 456987 6393 50141645
Sensitivity to weather change 11.49 10.16 23 457063 5978 50142060
Arteriovenous malformation 11.48 10.16 31 457055 1227 50146811
Product substitution issue 11.46 10.16 77 457009 13980 50134058
Urine chloride decreased 11.43 10.16 8 457078 78 50147960
Foot fracture 11.43 10.16 121 456965 19970 50128068
Injury associated with device 11.41 10.16 7 457079 3110 50144928
Rash scarlatiniform 11.40 10.16 9 457077 107 50147931
Carbon dioxide abnormal 11.40 10.16 10 457076 139 50147899
Hyperhidrosis 11.40 10.16 676 456410 88750 50059288
Infected skin ulcer 11.38 10.16 43 457043 2038 50146000
Stevens-Johnson syndrome 11.37 10.16 267 456819 21485 50126553
Troponin 11.25 10.16 4 457082 6 50148032
Base excess negative 11.25 10.16 4 457082 6 50148032
Small intestine gangrene 11.25 10.16 4 457082 6 50148032
Systolic dysfunction 11.22 10.16 34 457052 1438 50146600
Aortic valve calcification 11.21 10.16 16 457070 391 50147647
Rectal prolapse 11.15 10.16 38 457048 1711 50146327
Peritoneal dialysis 11.15 10.16 15 457071 346 50147692
Urine chloride increased 11.15 10.16 3 457083 0 50148038
Ammonia decreased 11.15 10.16 3 457083 0 50148038
Thyroid gland scan abnormal 11.15 10.16 3 457083 0 50148038
Benign small intestinal neoplasm 11.15 10.16 3 457083 0 50148038
Rectosigmoid cancer metastatic 11.15 10.16 3 457083 0 50148038
Oedema due to renal disease 11.15 10.16 3 457083 0 50148038
Tracheal operation 11.15 10.16 3 457083 0 50148038
Mitral valve disease mixed 11.15 10.16 3 457083 0 50148038
Autoimmune haemolytic anaemia 11.14 10.16 68 457018 3931 50144107
Physical deconditioning 11.14 10.16 17 457069 442 50147596
Escherichia sepsis 11.10 10.16 72 457014 4252 50143786
Lacrimation increased 11.08 10.16 99 456987 16893 50131145
White blood cell count increased 11.07 10.16 477 456609 41763 50106275
Haemothorax 11.07 10.16 41 457045 1925 50146113
Crohn's disease 11.03 10.16 16 457070 4717 50143321
Anaemia of chronic disease 11.02 10.16 39 457047 1790 50146248
Hypersensitivity vasculitis 11.02 10.16 68 457018 3947 50144091
Atrioventricular block second degree 11.01 10.16 63 457023 3558 50144480
Cystitis klebsiella 11.01 10.16 11 457075 182 50147856
Full blood count decreased 10.99 10.16 272 456814 22074 50125964
Vaginal discharge 10.99 10.16 19 457067 5221 50142817
Shunt occlusion 10.98 10.16 18 457068 498 50147540
Deafness bilateral 10.97 10.16 30 457056 1196 50146842
Portal hypertension 10.97 10.16 60 457026 3332 50144706
Electrocardiogram abnormal 10.96 10.16 111 456975 7494 50140544
Congenital oral malformation 10.91 10.16 11 457075 184 50147854
Cardiac resynchronisation therapy 10.91 10.16 5 457081 19 50148019
Patent ductus arteriosus repair 10.91 10.16 5 457081 19 50148019
QRS axis abnormal 10.90 10.16 26 457060 952 50147086
Hepatomegaly 10.87 10.16 147 456939 10646 50137392
Device malfunction 10.80 10.16 86 457000 15035 50133003
Alcohol interaction 10.77 10.16 3 457083 2141 50145897
Osteopenia 10.73 10.16 100 456986 16918 50131120
Leukaemic infiltration renal 10.71 10.16 5 457081 20 50148018
Coma 10.69 10.16 622 456464 56257 50091781
Pneumonia bacterial 10.69 10.16 107 456979 7202 50140836
Enuresis 10.66 10.16 3 457083 2126 50145912
Bronchial secretion retention 10.66 10.16 34 457052 1479 50146559
Large intestinal polypectomy 10.63 10.16 11 457075 190 50147848
Diarrhoea infectious 10.63 10.16 25 457061 907 50147131
Erythropenia 10.63 10.16 10 457076 153 50147885
Hepatic cytolysis 10.61 10.16 116 456970 7987 50140051
Craniotomy 10.59 10.16 11 457075 191 50147847
Haemoglobinaemia 10.56 10.16 6 457080 39 50147999
Cervical dysplasia 10.56 10.16 6 457080 2779 50145259
Oral contusion 10.55 10.16 7 457079 62 50147976
Linear IgA disease 10.55 10.16 30 457056 1224 50146814
Tumour lysis syndrome 10.55 10.16 108 456978 7313 50140725
Pulse absent 10.54 10.16 77 457009 4729 50143309
Chronic hepatic failure 10.54 10.16 17 457069 464 50147574
Wound complication 10.53 10.16 51 457035 2699 50145339
Cerebral artery embolism 10.47 10.16 22 457064 739 50147299
Acid base balance abnormal 10.42 10.16 12 457074 235 50147803
Cerebellar haemorrhage 10.42 10.16 30 457056 1233 50146805
Bone marrow failure 10.41 10.16 181 456905 27443 50120595
Intestinal ischaemia 10.41 10.16 100 456986 6657 50141381
Electrocardiogram T wave peaked 10.41 10.16 11 457075 195 50147843
Delirium 10.39 10.16 433 456653 37759 50110279
Ventricular enlargement 10.37 10.16 7 457079 64 50147974
Feeling hot 10.36 10.16 272 456814 38930 50109108
Hepatitis B reactivation 10.34 10.16 3 457083 2084 50145954
Injection site nodule 10.33 10.16 9 457077 3339 50144699
Splenomegaly 10.32 10.16 133 456953 9527 50138511
Abdominal hernia 10.32 10.16 72 457014 4357 50143681
Fear of eating 10.31 10.16 14 457072 326 50147712
Duodenal ulcer 10.31 10.16 100 456986 6675 50141363
Endometriosis 10.28 10.16 13 457073 4062 50143976
Blood creatine phosphokinase MB increased 10.28 10.16 28 457058 1114 50146924
PO2 abnormal 10.23 10.16 4 457082 9 50148029
Atrial thrombosis 10.23 10.16 33 457053 1444 50146594
Ear pruritus 10.23 10.16 5 457081 2521 50145517
Ammonia abnormal 10.21 10.16 8 457078 94 50147944
Long QT syndrome congenital 10.20 10.16 6 457080 42 50147996
Chemical burn of oral cavity 10.20 10.16 7 457079 66 50147972
Procedural pain 10.19 10.16 78 457008 13754 50134284

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure congestive 1756.92 11.54 3228 351229 73353 29146717
Acute kidney injury 1666.90 11.54 6927 347530 258340 28961730
Cardiac failure 1123.83 11.54 2747 351710 76540 29143530
Hyperkalaemia 912.37 11.54 2167 352290 59225 29160845
Drug ineffective 866.35 11.54 1924 352533 361246 28858824
Drug abuse 528.44 11.54 151 354306 79732 29140338
Oedema peripheral 508.89 11.54 2521 351936 101036 29119034
Renal failure 461.86 11.54 2709 351748 115890 29104180
Off label use 456.39 11.54 1957 352500 298843 28921227
Hypotension 433.02 11.54 3881 350576 190473 29029597
International normalised ratio increased 421.86 11.54 1330 353127 43042 29177028
Completed suicide 418.74 11.54 284 354173 89962 29130108
Toxicity to various agents 381.03 11.54 959 353498 172702 29047368
Dyspnoea 367.97 11.54 5720 348737 321012 28899058
Atrial fibrillation 309.40 11.54 2247 352210 103399 29116671
Blood creatinine increased 302.40 11.54 1899 352558 83203 29136867
Blood urea increased 276.65 11.54 853 353604 27259 29192811
Fluid retention 271.21 11.54 756 353701 22804 29197266
Cardiac failure chronic 270.48 11.54 360 354097 6107 29213963
Renal impairment 266.92 11.54 1779 352678 79554 29140516
Oedema 263.49 11.54 1072 353385 39411 29180659
Hypokalaemia 261.12 11.54 1243 353214 48960 29171110
Hepatic encephalopathy 220.81 11.54 485 353972 12550 29207520
Pulmonary hypertension 220 11.54 603 353854 18005 29202065
Chronic kidney disease 190.28 11.54 903 353554 35513 29184557
Foetal exposure during pregnancy 186.60 11.54 86 354371 33781 29186289
Melaena 183.70 11.54 801 353656 30375 29189695
Arthralgia 181.76 11.54 958 353499 138659 29081411
Headache 181.59 11.54 1280 353177 172727 29047343
Product use in unapproved indication 180.81 11.54 492 353965 86383 29133687
Hyponatraemia 179.43 11.54 1406 353051 66227 29153843
Suicidal ideation 176.52 11.54 98 354359 34618 29185452
Intentional overdose 176.22 11.54 123 354334 38405 29181665
Treatment failure 175.57 11.54 113 354344 36826 29183244
Suicide attempt 173.86 11.54 96 354361 34014 29186056
Anaemia 173.55 11.54 3375 351082 197576 29022494
Dehydration 171.78 11.54 2116 352341 112632 29107438
Bradycardia 167.88 11.54 1353 353104 64276 29155794
Hypervolaemia 164.86 11.54 524 353933 17021 29203049
Ascites 161.72 11.54 866 353591 35753 29184317
Ventricular tachycardia 161.55 11.54 616 353841 21958 29198112
Rheumatoid arthritis 149.22 11.54 101 354356 32051 29188019
Fall 146.57 11.54 2957 351500 174221 29045849
Therapeutic product effect incomplete 146.16 11.54 153 354304 39152 29180918
Myocardial infarction 144.92 11.54 1986 352471 108310 29111760
Pleural effusion 144.90 11.54 1407 353050 70501 29149569
Gastrointestinal haemorrhage 144.82 11.54 1524 352933 78009 29142061
Febrile neutropenia 143.86 11.54 774 353683 111466 29108604
Pulmonary oedema 143.81 11.54 941 353516 41794 29178276
Syncope 142.00 11.54 1546 352911 79825 29140245
Hypoglycaemia 138.80 11.54 1024 353433 47322 29172748
Injection site pain 137.57 11.54 112 354345 32334 29187736
Intentional product misuse 136.85 11.54 128 354329 34533 29185537
Orthostatic hypotension 136.82 11.54 586 353871 22043 29198027
Neutropenia 132.37 11.54 979 353478 130732 29089338
Pyrexia 123.60 11.54 2570 351887 285052 28935018
Pulmonary arterial hypertension 122.58 11.54 274 354183 7175 29212895
Lactic acidosis 121.97 11.54 698 353759 29549 29190521
Chronic obstructive pulmonary disease 121.30 11.54 874 353583 40081 29179989
Cardiac failure acute 120.94 11.54 310 354147 8882 29211188
Drug dependence 120.76 11.54 50 354407 20931 29199139
Intentional product use issue 117.90 11.54 205 354252 42293 29177777
Ejection fraction decreased 116.79 11.54 439 354018 15539 29204531
Generalised oedema 114.68 11.54 344 354113 10821 29209249
Blood potassium increased 114.19 11.54 411 354046 14240 29205830
Orthopnoea 114.15 11.54 200 354257 4360 29215710
Hypovolaemia 107.59 11.54 273 354184 7772 29212298
Right ventricular failure 106.83 11.54 269 354188 7621 29212449
Coronary artery disease 105.96 11.54 898 353559 43292 29176778
Drug hypersensitivity 104.37 11.54 443 354014 67963 29152107
N-terminal prohormone brain natriuretic peptide increased 103.91 11.54 122 354335 1810 29218260
Mitral valve incompetence 101.99 11.54 371 354086 12922 29207148
Seizure 101.93 11.54 675 353782 92448 29127622
Dyspnoea exertional 100.81 11.54 766 353691 35724 29184346
Infusion related reaction 99.37 11.54 238 354219 43648 29176422
Product dose omission issue 97.93 11.54 714 353743 95669 29124401
Rectal haemorrhage 96.99 11.54 728 353729 33821 29186249
Urticaria 93.58 11.54 338 354119 54322 29165748
Shock haemorrhagic 93.16 11.54 289 354168 9262 29210808
Nausea 91.93 11.54 2703 351754 286552 28933518
Aggression 89.29 11.54 182 354275 35359 29184711
Therapeutic product effect decreased 89.26 11.54 134 354323 29317 29190753
Product use issue 86.82 11.54 320 354137 51124 29168946
Psychotic disorder 86.60 11.54 70 354387 20284 29199786
Drug interaction 86.47 11.54 3031 351426 194354 29025716
Rash 86.16 11.54 1680 352777 188139 29031931
Drug intolerance 85.60 11.54 295 354162 48084 29171986
Nasopharyngitis 84.61 11.54 397 354060 59268 29160802
Metabolic alkalosis 83.62 11.54 88 354369 1148 29218922
Depression 83.03 11.54 638 353819 84509 29135561
Gout 83.01 11.54 412 354045 16499 29203571
Musculoskeletal stiffness 82.55 11.54 206 354251 37252 29182818
Gravitational oedema 82.46 11.54 62 354395 499 29219571
Acute pulmonary oedema 82.42 11.54 222 354235 6557 29213513
Pain 80.93 11.54 1507 352950 169925 29050145
Sinusitis 79.58 11.54 184 354273 34166 29185904
Mucosal inflammation 78.34 11.54 163 354294 31432 29188638
Tricuspid valve incompetence 78.20 11.54 250 354207 8144 29211926
Ischaemic cardiomyopathy 78.20 11.54 194 354263 5444 29214626
Brain natriuretic peptide increased 78.08 11.54 163 354294 4067 29216003
Drug withdrawal syndrome 77.58 11.54 61 354396 17923 29202147
Renal injury 76.80 11.54 283 354174 9919 29210151
Respiratory failure 76.79 11.54 1611 352846 95520 29124550
Hepatic failure 74.80 11.54 639 353818 30873 29189197
Blood pressure decreased 72.44 11.54 849 353608 44628 29175442
Insomnia 72.29 11.54 697 353760 88064 29132006
Synovitis 71.17 11.54 21 354436 10869 29209201
Hypersensitivity 69.82 11.54 361 354096 52542 29167528
Hypernatraemia 69.74 11.54 221 354236 7165 29212905
Congestive cardiomyopathy 69.72 11.54 206 354251 6424 29213646
Multiple sclerosis relapse 69.38 11.54 25 354432 11394 29208676
Cardiogenic shock 68.49 11.54 429 354028 18761 29201309
Immune reconstitution inflammatory syndrome 68.37 11.54 7 354450 7795 29212275
Exposure during pregnancy 66.98 11.54 11 354446 8543 29211527
Sedation 66.68 11.54 66 354391 17339 29202731
Intentional self-injury 66.54 11.54 33 354424 12428 29207642
Anuria 66.31 11.54 258 354199 9283 29210787
Acute myocardial infarction 65.88 11.54 878 353579 47560 29172510
Cardiomegaly 65.06 11.54 332 354125 13444 29206626
Urine output decreased 64.36 11.54 250 354207 8988 29211082
Colitis 63.42 11.54 179 354278 31069 29189001
Joint swelling 61.98 11.54 345 354112 49285 29170785
Overdose 61.57 11.54 635 353822 79184 29140886
Irritability 61.29 11.54 107 354350 22045 29198025
Injury 60.79 11.54 414 354043 18632 29201438
Anaphylactic reaction 60.47 11.54 152 354305 27421 29192649
Hepatic cirrhosis 59.97 11.54 336 354121 14108 29205962
Accidental exposure to product 59.69 11.54 27 354430 10726 29209344
Fatigue 59.18 11.54 3150 351307 313671 28906399
Fear 58.89 11.54 248 354209 9256 29210814
Venous pressure jugular increased 58.64 11.54 57 354400 672 29219398
Psoriatic arthropathy 58.27 11.54 54 354403 14637 29205433
Rales 57.94 11.54 210 354247 7300 29212770
Coronary artery bypass 57.54 11.54 154 354303 4531 29215539
Haematoma 57.37 11.54 475 353982 22737 29197333
Left ventricular failure 57.20 11.54 153 354304 4500 29215570
Akathisia 56.69 11.54 7 354450 6735 29213335
Injection site reaction 56.26 11.54 32 354425 11156 29208914
Cardiomyopathy 56.20 11.54 336 354121 14451 29205619
Left ventricular dysfunction 55.71 11.54 233 354224 8669 29211401
Serotonin syndrome 55.70 11.54 77 354380 17435 29202635
Drug ineffective for unapproved indication 55.49 11.54 53 354404 14161 29205909
Injection site erythema 54.53 11.54 52 354405 13904 29206166
Asthenia 54.35 11.54 3125 351332 212125 29007945
Pemphigoid 54.32 11.54 207 354250 7374 29212696
Jugular vein distension 54.32 11.54 51 354406 574 29219496
Appendicitis 53.71 11.54 19 354438 8760 29211310
Myocardial ischaemia 53.31 11.54 352 354105 15676 29204394
Azotaemia 53.17 11.54 147 354310 4410 29215660
Neuropathy peripheral 52.76 11.54 570 353887 70457 29149613
Malignant neoplasm progression 52.38 11.54 599 353858 73260 29146810
Rhabdomyolysis 52.14 11.54 1021 353436 59787 29160283
Haematotoxicity 51.60 11.54 9 354448 6690 29213380
Vomiting 51.10 11.54 2053 352404 210207 29009863
Poisoning 51.09 11.54 28 354429 9965 29210105
Cardiac disorder 50.48 11.54 675 353782 36588 29183482
Cytomegalovirus infection 50.11 11.54 129 354328 23086 29196984
Loss of personal independence in daily activities 49.97 11.54 148 354309 25292 29194778
Infection 49.65 11.54 635 353822 76116 29143954
Glomerular filtration rate decreased 49.41 11.54 266 354191 11000 29209070
Inappropriate schedule of product administration 49.29 11.54 321 354136 44151 29175919
Pathogen resistance 48.91 11.54 18 354439 8098 29211972
Cardioactive drug level increased 48.71 11.54 78 354379 1575 29218495
Arthropathy 47.90 11.54 118 354339 21436 29198634
Anhedonia 47.86 11.54 192 354265 7008 29213062
Aortic stenosis 47.82 11.54 128 354329 3766 29216304
Vitamin B1 deficiency 47.65 11.54 33 354424 230 29219840
Stomatitis 47.43 11.54 256 354201 36857 29183213
Erectile dysfunction 47.14 11.54 90 354367 17919 29202151
Colitis ulcerative 47.12 11.54 50 354407 12719 29207351
Diabetic ketoacidosis 46.91 11.54 75 354382 15998 29204072
Infective pulmonary exacerbation of cystic fibrosis 46.70 11.54 9 354448 6227 29213843
Abnormal behaviour 46.55 11.54 133 354324 22994 29197076
Substance abuse 46.39 11.54 12 354445 6775 29213295
Drug resistance 46.26 11.54 120 354337 21420 29198650
Diastolic dysfunction 45.52 11.54 149 354308 4915 29215155
Torsade de pointes 45.38 11.54 179 354278 6482 29213588
Back pain 44.87 11.54 910 353547 101374 29118696
Arrhythmia 44.83 11.54 573 353884 30740 29189330
Paraesthesia 44.59 11.54 421 354036 53424 29166646
Presyncope 44.56 11.54 338 354119 15751 29204319
Concomitant disease progression 43.60 11.54 91 354366 2270 29217800
Lymphadenopathy 43.44 11.54 154 354303 24895 29195175
Haemoglobin decreased 43.37 11.54 1648 352809 106727 29113343
Cardiac arrest 43.18 11.54 1337 353120 84254 29135816
Hypoglycaemic coma 43.06 11.54 86 354371 2077 29217993
Hypoaesthesia 42.18 11.54 423 354034 53044 29167026
Oliguria 41.79 11.54 188 354269 7224 29212846
Agitation 41.68 11.54 403 354054 50901 29169169
Uveitis 41.64 11.54 10 354447 5937 29214133
Atrioventricular block 41.56 11.54 180 354277 6802 29213268
Dyspnoea paroxysmal nocturnal 41.38 11.54 66 354391 1328 29218742
Bundle branch block left 41.08 11.54 148 354309 5129 29214941
Generalised tonic-clonic seizure 40.81 11.54 107 354350 19032 29201038
Chills 40.36 11.54 606 353851 70694 29149376
Device interaction 40.22 11.54 41 354416 514 29219556
Haematuria 40.18 11.54 748 353709 43391 29176679
Concomitant disease aggravated 39.94 11.54 141 354316 4837 29215233
Nephrolithiasis 39.89 11.54 162 354295 25172 29194898
Neutrophil count decreased 39.87 11.54 332 354125 43235 29176835
Blood pressure fluctuation 39.60 11.54 115 354342 19779 29200291
Gastrointestinal disorder 39.51 11.54 193 354264 28513 29191557
Peripheral swelling 39.47 11.54 1022 353435 62717 29157353
COVID-19 39.38 11.54 261 354196 35753 29184317
Sopor 39.36 11.54 245 354212 10689 29209381
Iron deficiency anaemia 39.12 11.54 211 354246 8731 29211339
Polyuria 38.74 11.54 183 354274 7179 29212891
Eosinophilia 38.56 11.54 421 354036 21740 29198330
Migraine 38.20 11.54 56 354401 12374 29207696
Acute respiratory failure 38.16 11.54 484 353973 25918 29194152
Oesophageal varices haemorrhage 37.50 11.54 93 354364 2609 29217461
Schizophrenia 37.20 11.54 16 354441 6549 29213521
Hallucination, auditory 37.18 11.54 36 354421 9557 29210513
Vascular purpura 37.03 11.54 63 354394 1340 29218730
Respiratory depression 36.79 11.54 66 354391 13457 29206613
Prostate cancer 36.67 11.54 169 354288 25358 29194712
Erythema 36.41 11.54 662 353795 74944 29145126
Tremor 36.33 11.54 641 353816 72897 29147173
Product storage error 36.30 11.54 16 354441 6454 29213616
Upper gastrointestinal haemorrhage 36.17 11.54 412 354045 21502 29198568
Euphoric mood 36.05 11.54 7 354450 4818 29215252
Hepatic cancer 35.83 11.54 163 354294 6293 29213777
Blood potassium decreased 35.73 11.54 316 354141 15418 29204652
Anger 35.52 11.54 47 354410 10843 29209227
Left ventricular dilatation 35.52 11.54 42 354415 628 29219442
Vision blurred 35.49 11.54 309 354148 39867 29180203
Device issue 35.34 11.54 25 354432 7755 29212315
Withdrawal syndrome 35.29 11.54 48 354409 10944 29209126
Acute graft versus host disease 34.96 11.54 13 354444 5811 29214259
Cardiorenal syndrome 34.72 11.54 42 354415 644 29219426
Neuroleptic malignant syndrome 34.64 11.54 90 354367 16058 29204012
Injection site swelling 34.61 11.54 37 354420 9380 29210690
Dialysis 34.44 11.54 225 354232 9983 29210087
Acrodermatitis enteropathica 34.36 11.54 10 354447 0 29220070
Blood pressure increased 34.36 11.54 650 353807 73153 29146917
White blood cell count decreased 33.82 11.54 751 353706 82611 29137459
Memory impairment 33.78 11.54 277 354180 36193 29183877
Multiple organ dysfunction syndrome 33.72 11.54 993 353464 62123 29157947
Therapeutic response shortened 33.66 11.54 8 354449 4783 29215287
Arthritis 33.41 11.54 170 354287 24849 29195221
Neoplasm progression 33.24 11.54 113 354344 18499 29201571
Sleep disorder 32.96 11.54 165 354292 24221 29195849
Cardiac output decreased 32.95 11.54 45 354412 783 29219287
Diverticulitis 32.64 11.54 106 354351 17598 29202472
Blood creatine increased 32.47 11.54 119 354338 4159 29215911
Abdominal pain 32.33 11.54 1310 353147 134047 29086023
Haemodialysis 32.13 11.54 217 354240 9737 29210333
Hyperuricaemia 31.81 11.54 165 354292 6724 29213346
Nightmare 31.72 11.54 55 354402 11362 29208708
Sexual dysfunction 31.65 11.54 15 354442 5799 29214271
Mental disorder 31.63 11.54 67 354390 12838 29207232
Syringe issue 31.58 11.54 4 354453 3774 29216296
Atrial flutter 31.53 11.54 279 354178 13615 29206455
Epistaxis 31.12 11.54 826 353631 50878 29169192
Low cardiac output syndrome 30.96 11.54 34 354423 467 29219603
Hepatotoxicity 30.88 11.54 110 354347 17757 29202313
Diplopia 30.83 11.54 73 354384 13445 29206625
Blood loss anaemia 30.81 11.54 170 354287 7096 29212974
Injection site haemorrhage 30.76 11.54 33 354424 8353 29211717
Therapeutic response decreased 30.72 11.54 172 354285 24539 29195531
Night sweats 30.69 11.54 85 354372 14847 29205223
Pancreatitis 30.68 11.54 265 354192 34249 29185821
International normalised ratio decreased 30.51 11.54 115 354342 4075 29215995
Cardiac murmur 30.27 11.54 158 354299 6455 29213615
Hypocoagulable state 30.14 11.54 45 354412 853 29219217
Premature baby 30.12 11.54 106 354351 17174 29202896
Sudden cardiac death 30.05 11.54 96 354361 3126 29216944
Asthma 30.04 11.54 260 354197 33589 29186481
Muscle spasms 30.04 11.54 574 353883 64508 29155562
Cardiac amyloidosis 29.95 11.54 45 354412 858 29219212
Polyomavirus-associated nephropathy 29.88 11.54 3 354454 3393 29216677
Dystonia 29.88 11.54 44 354413 9705 29210365
Transfusion 29.79 11.54 169 354288 7129 29212941
Suspected suicide 29.68 11.54 6 354451 4014 29216056
Normochromic normocytic anaemia 29.68 11.54 104 354353 3554 29216516
Blood lactic acid 29.62 11.54 28 354429 318 29219752
Subdural haematoma 29.55 11.54 341 354116 17852 29202218
Hyperhidrosis 29.55 11.54 570 353887 63970 29156100
Cognitive disorder 29.52 11.54 163 354294 23336 29196734
Anxiety 29.44 11.54 788 353669 84577 29135493
Hypoxia 29.41 11.54 760 353697 46619 29173451
Basal cell carcinoma 29.30 11.54 104 354353 16806 29203264
Haematemesis 29.29 11.54 436 354021 24190 29195880
No adverse event 29.29 11.54 109 354348 17369 29202701
Ankylosing spondylitis 29.28 11.54 7 354450 4169 29215901
Congestive hepatopathy 29.27 11.54 64 354393 1650 29218420
Paranoia 28.90 11.54 46 354411 9831 29210239
Acute graft versus host disease in skin 28.69 11.54 10 354447 4654 29215416
Post transplant lymphoproliferative disorder 28.65 11.54 15 354442 5478 29214592
Depressed mood 28.60 11.54 101 354356 16347 29203723
Mucormycosis 28.55 11.54 13 354444 5145 29214925
Influenza like illness 28.46 11.54 174 354283 24296 29195774
Multiple-drug resistance 28.43 11.54 6 354451 3894 29216176
Herpes zoster 28.41 11.54 227 354230 29825 29190245
Dyskinesia 28.11 11.54 134 354323 19927 29200143
Progressive multifocal leukoencephalopathy 28.07 11.54 38 354419 8681 29211389
Dilatation atrial 28.00 11.54 66 354391 1791 29218279
Emotional distress 27.99 11.54 272 354185 13623 29206447
Anal abscess 27.90 11.54 14 354443 5237 29214833
Hypocalcaemia 27.84 11.54 374 354083 20291 29199779
Disturbance in attention 27.80 11.54 147 354310 21277 29198793
Tinnitus 27.74 11.54 95 354362 15519 29204551
Mania 27.64 11.54 38 354419 8625 29211445
Therapy partial responder 27.41 11.54 14 354443 5185 29214885
Peritonitis bacterial 27.37 11.54 139 354318 5617 29214453
C-reactive protein abnormal 27.15 11.54 23 354434 6513 29213557
Panic attack 27.09 11.54 36 354421 8290 29211780
Prothrombin time prolonged 27.01 11.54 190 354267 8642 29211428
Tuberculosis 26.75 11.54 28 354429 7168 29212902
Extrapyramidal disorder 26.74 11.54 56 354401 10775 29209295
Ventricular fibrillation 26.73 11.54 299 354158 15534 29204536
Tenosynovitis 26.69 11.54 6 354451 3727 29216343
Atrioventricular block complete 26.68 11.54 176 354281 7835 29212235
Tachycardia 26.67 11.54 662 353795 71748 29148322
Cor pulmonale 26.58 11.54 37 354420 656 29219414
Lipodystrophy acquired 26.54 11.54 3 354454 3091 29216979
Hepatorenal syndrome 26.52 11.54 74 354383 2232 29217838
Tardive dyskinesia 26.49 11.54 15 354442 5243 29214827
Ventricular extrasystoles 26.38 11.54 217 354240 10365 29209705
Leukopenia 26.36 11.54 484 353973 54719 29165351
Somnolence 26.06 11.54 893 353564 93062 29127008
Amnesia 25.82 11.54 162 354295 22481 29197589
Dyspnoea at rest 25.75 11.54 91 354366 3123 29216947
Nephrotic syndrome 25.47 11.54 146 354311 6182 29213888
Mood altered 25.46 11.54 36 354421 8075 29211995
Priapism 25.33 11.54 11 354446 4477 29215593
Hydrothorax 25.28 11.54 29 354428 419 29219651
Neurotoxicity 25.23 11.54 90 354367 14523 29205547
Dysmorphism 25.19 11.54 3 354454 2968 29217102
Bradyarrhythmia 25.14 11.54 66 354391 1919 29218151
Alopecia 24.73 11.54 131 354326 18953 29201117
Chronic hepatic failure 24.71 11.54 29 354428 430 29219640
Neutropenic sepsis 24.67 11.54 66 354391 11661 29208409
Injection site bruising 24.43 11.54 33 354424 7547 29212523
Blood pressure systolic decreased 24.35 11.54 101 354356 3743 29216327
Frequent bowel movements 24.33 11.54 46 354411 9193 29210877
Myalgia 24.30 11.54 688 353769 73331 29146739
Toxic epidermal necrolysis 24.23 11.54 328 354129 17825 29202245
Psoriasis 24.16 11.54 258 354199 31969 29188101
Nephrogenic anaemia 24.12 11.54 65 354392 1920 29218150
Pneumonia 24.12 11.54 4273 350184 315899 28904171
Poisoning deliberate 24.01 11.54 20 354437 5711 29214359
Osteonecrosis of jaw 23.89 11.54 109 354348 16401 29203669
Flushing 23.85 11.54 227 354230 28765 29191305
Left ventricular enlargement 23.81 11.54 34 354423 618 29219452
Oropharyngeal pain 23.79 11.54 230 354227 29055 29191015
Pseudoporphyria 23.66 11.54 24 354433 299 29219771
Pericardial haemorrhage 23.50 11.54 83 354374 2848 29217222
Hepatitis B reactivation 23.47 11.54 5 354452 3224 29216846
Aspergillus infection 23.45 11.54 58 354399 10523 29209547
Haemoconcentration 23.43 11.54 11 354446 31 29220039
Left ventricular hypertrophy 23.38 11.54 149 354308 6554 29213516
Musculoskeletal pain 23.27 11.54 228 354229 28725 29191345
Neuromyopathy 23.24 11.54 40 354417 859 29219211
Salivary hypersecretion 23.14 11.54 33 354424 7376 29212694
Cardiac valve disease 23.13 11.54 81 354376 2767 29217303
Aortic valve incompetence 23.10 11.54 120 354337 4893 29215177
Atrial tachycardia 23.03 11.54 63 354394 1878 29218192
Haemophagocytic lymphohistiocytosis 22.95 11.54 58 354399 10446 29209624
Pulmonary congestion 22.91 11.54 239 354218 12197 29207873
Adverse drug reaction 22.91 11.54 181 354276 23839 29196231
Injection site mass 22.90 11.54 19 354438 5436 29214634
Graft versus host disease 22.76 11.54 51 354406 9577 29210493
Bone pain 22.63 11.54 129 354328 18323 29201747
Varices oesophageal 22.62 11.54 86 354371 3060 29217010
Unevaluable event 22.54 11.54 492 353965 29359 29190711
Mitral valve thickening 22.51 11.54 25 354432 348 29219722
Apparent death 22.46 11.54 7 354450 3497 29216573
Pericardial effusion 22.37 11.54 368 354089 20840 29199230
Influenza 22.32 11.54 360 354097 41521 29178549
Epstein-Barr virus infection 22.25 11.54 28 354429 6601 29213469
Hyperparathyroidism secondary 22.22 11.54 48 354409 1227 29218843
Feeling abnormal 22.21 11.54 490 353967 53955 29166115
Hypercapnia 22.13 11.54 96 354361 3630 29216440
Abdominal discomfort 21.94 11.54 423 354034 47480 29172590
Eye pain 21.67 11.54 69 354388 11526 29208544
Posterior reversible encephalopathy syndrome 21.67 11.54 47 354410 8929 29211141
Dysphagia 21.65 11.54 497 353960 54429 29165641
Incorrect dose administered 21.64 11.54 272 354185 32712 29187358
Small for dates baby 21.46 11.54 8 354449 3571 29216499
Enteritis 21.45 11.54 30 354427 6761 29213309
Hypercreatinaemia 21.36 11.54 16 354441 128 29219942
Maternal drugs affecting foetus 21.26 11.54 10 354447 3883 29216187
Ventricular failure 21.23 11.54 14 354443 89 29219981
Dilatation ventricular 21.22 11.54 71 354386 2369 29217701
Blood creatinine abnormal 21.20 11.54 63 354394 1971 29218099
Prerenal failure 21.18 11.54 58 354399 1730 29218340
Mental impairment 21.14 11.54 49 354408 9092 29210978
Renal ischaemia 21.09 11.54 29 354428 508 29219562
Hyponatraemic syndrome 21.08 11.54 18 354439 177 29219893
Dermatitis bullous 21.05 11.54 132 354325 5774 29214296
Muscle haemorrhage 21.04 11.54 88 354369 3274 29216796
Mood swings 21.00 11.54 34 354423 7217 29212853
Ventricular internal diameter abnormal 20.99 11.54 14 354443 91 29219979
Hypersensitivity vasculitis 20.97 11.54 86 354371 3171 29216899
Scrotal oedema 20.96 11.54 51 354406 1413 29218657
Emotional disorder 20.92 11.54 17 354440 4914 29215156
Impaired work ability 20.90 11.54 22 354435 5618 29214452
Catatonia 20.77 11.54 14 354443 4454 29215616
Vascular graft 20.76 11.54 49 354408 1331 29218739
Pneumocystis jirovecii pneumonia 20.74 11.54 117 354340 16662 29203408
Hepatocellular carcinoma 20.70 11.54 150 354307 6888 29213182
Hypomagnesaemia 20.66 11.54 309 354148 17159 29202911
Coma hepatic 20.66 11.54 26 354431 416 29219654
Eyelid ptosis 20.64 11.54 19 354438 5167 29214903
Blood uric acid increased 20.61 11.54 129 354328 5639 29214431
Atrial septal defect 20.46 11.54 31 354426 6758 29213312
Haemoptysis 20.42 11.54 495 353962 30055 29190015
Drug screen positive 20.39 11.54 10 354447 3791 29216279
Atrioventricular block first degree 20.30 11.54 121 354336 5198 29214872
Muscle twitching 20.23 11.54 41 354416 7985 29212085
Multiple sclerosis 20.21 11.54 22 354435 5532 29214538
Gastrointestinal vascular malformation haemorrhagic 20.15 11.54 29 354428 531 29219539
Alcohol poisoning 20.11 11.54 6 354451 3083 29216987
Bronchopulmonary aspergillosis 20.02 11.54 78 354379 12266 29207804
Ear infection 19.89 11.54 42 354415 8058 29212012
Intraocular pressure increased 19.71 11.54 17 354440 4772 29215298
Anal fistula 19.70 11.54 13 354444 4182 29215888
Incorrect route of product administration 19.68 11.54 65 354392 10736 29209334
Chronic graft versus host disease 19.58 11.54 12 354445 4017 29216053
Alcohol abuse 19.58 11.54 14 354443 4319 29215751
Wrong technique in product usage process 19.58 11.54 262 354195 31166 29188904
Dermatitis exfoliative generalised 19.57 11.54 78 354379 2838 29217232
Dizziness 19.56 11.54 2577 351880 187107 29032963
Graft versus host disease in skin 19.53 11.54 8 354449 3371 29216699
Cellulitis 19.50 11.54 702 353755 45138 29174932
Candida infection 19.46 11.54 105 354352 15120 29204950
Hypercreatininaemia 19.44 11.54 26 354431 443 29219627
Ischaemic stroke 19.44 11.54 284 354173 15693 29204377
Microcytic anaemia 19.38 11.54 61 354396 1970 29218100
Pruritus 19.28 11.54 1175 353282 115674 29104396
Occult blood positive 19.18 11.54 92 354365 3632 29216438
Metabolic acidosis 19.15 11.54 589 353868 37073 29182997
Visual impairment 19.11 11.54 246 354211 29462 29190608
Pulmonary arterial pressure increased 19.06 11.54 41 354416 1045 29219025
Maternal exposure during pregnancy 19.06 11.54 13 354444 4110 29215960
Nephrocalcinosis 19.05 11.54 28 354429 523 29219547
Knee arthroplasty 19.02 11.54 25 354432 5784 29214286
Crepitations 18.98 11.54 74 354383 2665 29217405
Tendonitis 18.96 11.54 42 354415 7919 29212151
Ammonia increased 18.93 11.54 97 354360 3934 29216136
Second primary malignancy 18.90 11.54 32 354425 6673 29213397
Creatinine renal clearance decreased 18.88 11.54 80 354377 2994 29217076
Weight decreased 18.77 11.54 1555 352902 149350 29070720
Exposure to toxic agent 18.69 11.54 4 354453 2571 29217499
Hepatitis B 18.68 11.54 23 354434 5474 29214596
Lower gastrointestinal haemorrhage 18.67 11.54 165 354292 8048 29212022
Arteriospasm coronary 18.59 11.54 4 354453 2561 29217509
Unintentional medical device removal 18.57 11.54 3 354454 2358 29217712
Drug specific antibody present 18.54 11.54 4 354453 2557 29217513
Respiratory arrest 18.49 11.54 209 354248 25624 29194446
Squamous cell carcinoma 18.46 11.54 62 354395 10189 29209881
Gastric varices 18.42 11.54 23 354434 365 29219705
Anticoagulation drug level increased 18.39 11.54 26 354431 468 29219602
Graft versus host disease in gastrointestinal tract 18.37 11.54 8 354449 3250 29216820
Faeces discoloured 18.13 11.54 242 354215 13109 29206961
Feeling hot 18.08 11.54 110 354347 15378 29204692
Electrocardiogram QT prolonged 18.07 11.54 564 353893 35573 29184497
Alcohol interaction 18.05 11.54 5 354452 2698 29217372
Diabetic foot 17.98 11.54 63 354394 2153 29217917
Central nervous system lesion 17.79 11.54 25 354432 5623 29214447
Viral mutation identified 17.79 11.54 4 354453 2484 29217586
Speech disorder 17.73 11.54 188 354269 23328 29196742
Asterixis 17.70 11.54 40 354417 1055 29219015
Virologic failure 17.69 11.54 6 354451 2841 29217229
Respiratory distress 17.65 11.54 507 353950 31599 29188471
Neck pain 17.61 11.54 168 354289 21279 29198791
Ventricular hypokinesia 17.52 11.54 104 354353 4461 29215609
Cardio-respiratory distress 17.47 11.54 14 354443 125 29219945
Product quality issue 17.47 11.54 115 354342 15780 29204290
Photophobia 17.47 11.54 28 354429 5967 29214103
Urinary tract discomfort 17.45 11.54 13 354444 103 29219967
Purpura 17.28 11.54 178 354279 9054 29211016
Ventricular dyssynchrony 17.21 11.54 7 354450 12 29220058
Gastrointestinal angiodysplasia 17.19 11.54 27 354430 536 29219534
Thirst decreased 17.18 11.54 5 354452 0 29220070
Cardiospasm 17.18 11.54 5 354452 0 29220070
Upper motor neurone lesion 17.06 11.54 13 354444 107 29219963
Peripheral venous disease 17.04 11.54 64 354393 2264 29217806
Status epilepticus 17.00 11.54 69 354388 10725 29209345
Narrow anterior chamber angle 16.96 11.54 13 354444 108 29219962
Pulmonary tuberculosis 16.95 11.54 16 354441 4299 29215771
Ventricular dysfunction 16.95 11.54 82 354375 3249 29216821
Myelosuppression 16.94 11.54 82 354375 12145 29207925
Apathy 16.89 11.54 30 354427 6141 29213929
Hepatic enzyme increased 16.87 11.54 294 354163 33505 29186565
Peripheral vascular disorder 16.86 11.54 103 354354 4464 29215606
Spontaneous haematoma 16.82 11.54 25 354432 472 29219598
Activated partial thromboplastin time prolonged 16.81 11.54 154 354303 7588 29212482
Heart sounds abnormal 16.81 11.54 29 354428 624 29219446
Posthaemorrhagic hydrocephalus 16.74 11.54 12 354445 89 29219981
Bone marrow failure 16.67 11.54 230 354227 27219 29192851
Crying 16.55 11.54 24 354433 5327 29214743
Drug level decreased 16.54 11.54 31 354426 6216 29213854
Urine calcium decreased 16.53 11.54 6 354451 6 29220064
Renal artery thrombosis 16.49 11.54 19 354438 276 29219794
Drug abuser 16.48 11.54 13 354444 3814 29216256
Medication error 16.46 11.54 351 354106 20860 29199210
Cataract 16.43 11.54 180 354277 22198 29197872
Road traffic accident 16.39 11.54 114 354343 15447 29204623
Restlessness 16.31 11.54 178 354279 21967 29198103
Left atrial enlargement 16.28 11.54 31 354426 722 29219348
Abscess 16.28 11.54 61 354396 9701 29210369
Delusion 16.26 11.54 74 354383 11142 29208928
Ejection fraction abnormal 16.21 11.54 32 354425 766 29219304
Increased appetite 16.14 11.54 30 354427 6034 29214036
Paracentesis 16.06 11.54 22 354435 384 29219686
Device use error 16.02 11.54 3 354454 2119 29217951
Accidental death 15.98 11.54 3 354454 2115 29217955
Strongyloidiasis 15.97 11.54 4 354453 2308 29217762
Plasma cell myeloma 15.93 11.54 569 353888 36546 29183524
Hypogammaglobulinaemia 15.92 11.54 29 354428 5878 29214192
Subarachnoid haemorrhage 15.89 11.54 182 354275 9510 29210560
Ventricular dyskinesia 15.79 11.54 16 354441 199 29219871
Hypochromasia 15.77 11.54 19 354438 290 29219780
Gouty tophus 15.71 11.54 13 354444 122 29219948
BK virus infection 15.68 11.54 20 354437 4687 29215383
Arteriosclerosis 15.67 11.54 190 354267 10066 29210004
Abdominal cavity drainage 15.66 11.54 20 354437 325 29219745
Acquired macroglossia 15.63 11.54 7 354450 17 29220053
Base excess decreased 15.61 11.54 16 354441 202 29219868
Sinus node dysfunction 15.59 11.54 87 354370 3647 29216423
Base excess increased 15.58 11.54 8 354449 29 29220041
Aortic valve stenosis 15.58 11.54 60 354397 2148 29217922
Left ventricle outflow tract obstruction 15.54 11.54 13 354444 124 29219946
Alanine aminotransferase abnormal 15.53 11.54 8 354449 2949 29217121
Product substitution issue 15.50 11.54 57 354400 9115 29210955
Diabetic nephropathy 15.48 11.54 54 354403 1841 29218229
Superinfection 15.47 11.54 56 354401 1945 29218125
Hypoperfusion 15.46 11.54 36 354421 969 29219101
Gastritis haemorrhagic 15.41 11.54 41 354416 1202 29218868
Mitral valve calcification 15.40 11.54 25 354432 511 29219559
Social avoidant behaviour 15.40 11.54 8 354449 2934 29217136
Post procedural haematoma 15.37 11.54 45 354412 1396 29218674
Exercise tolerance decreased 15.35 11.54 95 354362 4136 29215934
Disinhibition 15.35 11.54 6 354451 2601 29217469
Gastritis erosive 15.33 11.54 114 354343 5279 29214791
Troponin increased 15.31 11.54 173 354284 9010 29211060
Epilepsy 15.30 11.54 144 354313 18288 29201782
Cytomegalovirus chorioretinitis 15.25 11.54 10 354447 3228 29216842
Ventricular arrhythmia 15.24 11.54 101 354356 4503 29215567
Ecchymosis 15.24 11.54 128 354329 6152 29213918
Cardioactive drug level decreased 15.24 11.54 10 354447 63 29220007
Throat irritation 15.24 11.54 54 354403 8731 29211339
Fabry's disease 15.23 11.54 6 354451 9 29220061
Angina unstable 15.20 11.54 198 354259 10667 29209403
Brain natriuretic peptide abnormal 15.15 11.54 19 354438 303 29219767
International normalised ratio abnormal 15.12 11.54 73 354384 2890 29217180
Neonatal respiratory distress syndrome 15.11 11.54 14 354443 3796 29216274
Dermatitis exfoliative 15.09 11.54 130 354327 6295 29213775
Sinus arrhythmia 15.04 11.54 29 354428 682 29219388
Gouty arthritis 15.03 11.54 35 354422 942 29219128
Cytomegalovirus infection reactivation 15.03 11.54 11 354446 3353 29216717
Acquired haemophilia 15.00 11.54 32 354425 811 29219259
Polyneuropathy 14.88 11.54 85 354372 12067 29208003
Adult failure to thrive 14.87 11.54 5 354452 3 29220067
Pseudo-Bartter syndrome 14.85 11.54 6 354451 10 29220060
Drug-induced liver injury 14.80 11.54 177 354280 21478 29198592
Pulmonary arterial wedge pressure increased 14.78 11.54 11 354446 87 29219983
International normalised ratio fluctuation 14.76 11.54 36 354421 999 29219071
Osteonecrosis 14.76 11.54 98 354359 13421 29206649
Atrial thrombosis 14.76 11.54 55 354402 1938 29218132
Injection site pruritus 14.64 11.54 30 354427 5819 29214251
Dependence on oxygen therapy 14.61 11.54 14 354443 162 29219908
Amyloidosis 14.59 11.54 55 354402 1949 29218121
Middle insomnia 14.53 11.54 29 354428 5679 29214391
Abnormal dreams 14.51 11.54 39 354418 6881 29213189
Right ventricular dysfunction 14.51 11.54 34 354423 919 29219151
Hypoalbuminaemia 14.50 11.54 188 354269 10117 29209953
Renal artery stenosis 14.43 11.54 54 354403 1907 29218163
Viral infection 14.40 11.54 111 354346 14699 29205371
Right atrial enlargement 14.39 11.54 16 354441 223 29219847
Drug level below therapeutic 14.38 11.54 18 354439 4253 29215817
Diffuse large B-cell lymphoma 14.22 11.54 34 354423 6242 29213828
Uraemic encephalopathy 14.19 11.54 17 354440 258 29219812
Blood bilirubin increased 14.16 11.54 518 353939 33375 29186695
Tongue disorder 14.13 11.54 21 354436 4615 29215455
Pulmonary vein stenosis 14.11 11.54 8 354449 37 29220033
Head injury 14.10 11.54 271 354186 15810 29204260
Grip strength decreased 14.10 11.54 5 354452 2302 29217768
Encephalopathy 14.09 11.54 479 353978 30564 29189506
Liver function test increased 14.09 11.54 84 354373 11801 29208269
Coagulation time prolonged 14.08 11.54 39 354418 1171 29218899
Ventricular flutter 14.07 11.54 10 354447 73 29219997
Long QT syndrome 14.05 11.54 59 354398 2199 29217871
Loss of libido 13.99 11.54 5 354452 2291 29217779
Euglycaemic diabetic ketoacidosis 13.99 11.54 7 354450 2623 29217447
Antipsychotic drug level increased 13.98 11.54 11 354446 3232 29216838
Coronary arterial stent insertion 13.83 11.54 87 354370 3810 29216260
Malignant melanoma 13.81 11.54 42 354415 7119 29212951
Oxygen consumption decreased 13.77 11.54 14 354443 175 29219895
Electrocardiogram T wave peaked 13.76 11.54 23 354434 482 29219588
Toxic skin eruption 13.73 11.54 178 354279 9579 29210491
Obsessive-compulsive disorder 13.69 11.54 21 354436 4555 29215515
Mumps 13.65 11.54 10 354447 77 29219993
Portopulmonary hypertension 13.56 11.54 6 354451 14 29220056
Phlebitis deep 13.56 11.54 6 354451 14 29220056
Blood potassium abnormal 13.52 11.54 35 354422 1009 29219061
Sudden death 13.49 11.54 241 354216 13869 29206201
Melanoderma 13.46 11.54 13 354444 152 29219918
Heparin-induced thrombocytopenia 13.45 11.54 104 354353 4875 29215195
Aspiration pleural cavity 13.43 11.54 29 354428 741 29219329
Disorganised speech 13.41 11.54 27 354430 656 29219414
Transaminases increased 13.37 11.54 191 354266 22471 29197599
Alkalosis 13.31 11.54 11 354446 103 29219967
Oropharyngeal discomfort 13.30 11.54 7 354450 2549 29217521
Blood pressure diastolic abnormal 13.26 11.54 7 354450 2544 29217526
Ejection fraction 13.25 11.54 10 354447 81 29219989
Crohn's disease 13.24 11.54 10 354447 2999 29217071
Angina pectoris 13.22 11.54 432 354025 27418 29192652
Attention deficit hyperactivity disorder 13.22 11.54 5 354452 2212 29217858
Blindness 13.20 11.54 87 354370 11936 29208134
Bipolar disorder 13.20 11.54 12 354445 3283 29216787
Visual field defect 13.19 11.54 18 354439 4098 29215972
Hepatic steatosis 13.17 11.54 115 354342 14831 29205239
Coagulopathy 13.15 11.54 294 354163 17613 29202457
Meningitis aseptic 13.13 11.54 6 354451 2370 29217700
Alveolar lung disease 13.12 11.54 19 354438 350 29219720
Device leakage 13.09 11.54 21 354436 4474 29215596
Lymphoproliferative disorder 13.03 11.54 7 354450 2520 29217550
Blood sodium decreased 13.00 11.54 249 354208 14518 29205552
Upper respiratory tract infection 12.98 11.54 240 354217 27109 29192961
Hypertriglyceridaemia 12.93 11.54 46 354411 7429 29212641
Rash maculo-papular 12.92 11.54 382 354075 23907 29196163
Cytokine release syndrome 12.91 11.54 98 354359 13021 29207049
Visual acuity reduced 12.87 11.54 115 354342 14761 29205309
Hypertensive cardiomyopathy 12.79 11.54 12 354445 135 29219935
Adenovirus infection 12.74 11.54 21 354436 4426 29215644
Intervertebral disc protrusion 12.69 11.54 57 354400 8613 29211457
Gastric ulcer 12.69 11.54 238 354219 13823 29206247
Diverticulum intestinal 12.65 11.54 75 354382 3215 29216855
Lividity 12.65 11.54 12 354445 137 29219933
Pruritus genital 12.64 11.54 23 354434 517 29219553
Peripheral arterial occlusive disease 12.60 11.54 104 354353 4972 29215098
Scrotal swelling 12.59 11.54 38 354419 1199 29218871
Skin toxicity 12.58 11.54 16 354441 3755 29216315
Ischaemic hepatitis 12.55 11.54 44 354413 1504 29218566
Antipsychotic drug level below therapeutic 12.55 11.54 4 354453 1970 29218100
Hypochloraemia 12.55 11.54 23 354434 520 29219550
Blood bicarbonate increased 12.53 11.54 21 354436 441 29219629
Cardiac ablation 12.51 11.54 27 354430 690 29219380
Gastrointestinal arteriovenous malformation 12.49 11.54 18 354439 330 29219740
Drug reaction with eosinophilia and systemic symptoms 12.48 11.54 431 354026 27561 29192509
Pericardial drainage 12.42 11.54 9 354448 68 29220002
Cerebral haemorrhage 12.33 11.54 477 353980 30949 29189121
Fistula 12.33 11.54 27 354430 5112 29214958
Hypovolaemic shock 12.30 11.54 119 354338 5953 29214117
Alanine aminotransferase increased 12.29 11.54 710 353747 70234 29149836
Degenerative aortic valve disease 12.28 11.54 6 354451 19 29220051
Illness 12.27 11.54 40 354417 6634 29213436
Cutaneous vasculitis 12.25 11.54 74 354383 3194 29216876
Impulsive behaviour 12.24 11.54 4 354453 1939 29218131
Cryptorchism 12.23 11.54 4 354453 1938 29218132
Tongue oedema 12.22 11.54 62 354395 2504 29217566
Nephrogenic systemic fibrosis 12.17 11.54 85 354372 3857 29216213
Coordination abnormal 12.16 11.54 44 354413 7070 29213000
Kidney small 12.12 11.54 8 354449 51 29220019
Muscle rigidity 11.97 11.54 65 354392 9346 29210724
Metastases to liver 11.93 11.54 88 354369 11768 29208302
Blood pressure diastolic increased 11.93 11.54 16 354441 3670 29216400
Lymphoma 11.89 11.54 69 354388 9759 29210311
Hyperaldosteronism 11.82 11.54 10 354447 97 29219973
Oesophageal variceal ligation 11.82 11.54 9 354448 74 29219996
Ectopic gastric mucosa 11.81 11.54 5 354452 10 29220060
Depressive symptom 11.80 11.54 3 354454 1714 29218356
Tooth infection 11.78 11.54 31 354426 5508 29214562
Haematocrit decreased 11.74 11.54 442 354015 28580 29191490
C-reactive protein increased 11.73 11.54 423 354034 43840 29176230
Spinal epidural haematoma 11.69 11.54 15 354442 245 29219825
Brain oedema 11.69 11.54 92 354365 12128 29207942
Pulmonary embolism 11.68 11.54 775 353682 75759 29144311
Myocarditis 11.67 11.54 80 354377 10876 29209194
Blood urea abnormal 11.61 11.54 27 354430 726 29219344
Osteoarthritis 11.61 11.54 150 354307 17953 29202117
Diabetic gangrene 11.59 11.54 13 354444 183 29219887
Partial seizures 11.59 11.54 18 354439 3885 29216185
Anaphylactic shock 11.58 11.54 103 354354 13233 29206837
Endocarditis 11.56 11.54 112 354345 5604 29214466
Pulmonary hypertensive crisis 11.55 11.54 12 354445 154 29219916

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 4160.54 10.70 12326 674982 436914 63374510
Cardiac failure congestive 3582.29 10.70 5586 681722 124994 63686430
Cardiac failure 2106.52 10.70 4473 682835 127900 63683524
Hyperkalaemia 2074.43 10.70 3802 683506 97327 63714097
Drug ineffective 1945.11 10.70 3767 683541 836480 62974944
Renal failure 1106.00 10.70 4343 682965 177345 63634079
Oedema peripheral 1048.66 10.70 4730 682578 205587 63605837
International normalised ratio increased 1037.63 10.70 2478 684830 76689 63734735
Hypotension 1009.12 10.70 7229 680079 373745 63437679
Off label use 971.69 10.70 3476 683832 629330 63182094
Hyponatraemia 959.94 10.70 3616 683692 144723 63666701
Completed suicide 947.61 10.70 612 686696 223802 63587622
Dyspnoea 845.00 10.70 11501 675807 707173 63104251
Hypokalaemia 805.44 10.70 2992 684316 118911 63692513
Atrial fibrillation 789.03 10.70 3762 683546 167327 63644097
Rheumatoid arthritis 685.20 10.70 454 686854 163840 63647584
Drug intolerance 655.17 10.70 622 686686 187370 63624054
Arthralgia 650.05 10.70 2471 684837 439789 63371635
Drug interaction 612.16 10.70 6219 681089 355864 63455560
Infusion related reaction 611.68 10.70 512 686796 163955 63647469
Bradycardia 603.60 10.70 2679 684629 115540 63695884
Pulmonary hypertension 587.44 10.70 1371 685937 41768 63769656
Anaemia 585.18 10.70 6387 680921 372293 63439131
Renal impairment 582.18 10.70 2913 684395 132104 63679320
Blood creatinine increased 578.78 10.70 2920 684388 132862 63678562
Hand deformity 575.52 10.70 21 687287 62750 63748674
Treatment failure 570.55 10.70 265 687043 116551 63694873
Pemphigus 568.27 10.70 17 687291 60684 63750740
Synovitis 559.79 10.70 179 687129 98911 63712513
Arthropathy 558.26 10.70 296 687012 120671 63690753
Drug abuse 555.67 10.70 363 686945 132011 63679413
Drug hypersensitivity 555.38 10.70 1056 686252 236759 63574665
Therapeutic product effect decreased 552.15 10.70 269 687039 115082 63696342
Dehydration 535.71 10.70 4049 683259 212714 63598710
Melaena 521.00 10.70 1500 685808 52048 63759376
Joint swelling 512.02 10.70 946 686362 214436 63596988
Fluid retention 509.42 10.70 1595 685713 58011 63753413
Alopecia 509.35 10.70 609 686699 165081 63646343
Blood urea increased 508.60 10.70 1316 685992 42837 63768587
Oedema 504.92 10.70 2130 685178 89805 63721619
Pulmonary arterial hypertension 488.50 10.70 929 686379 24438 63786986
Myocardial infarction 487.49 10.70 3231 684077 162590 63648834
Maternal exposure during pregnancy 473.68 10.70 214 687094 95670 63715754
Fall 469.33 10.70 6626 680682 410200 63401224
Gastrointestinal haemorrhage 454.98 10.70 2684 684624 129628 63681796
Contraindicated product administered 453.46 10.70 295 687013 107534 63703890
Hypersensitivity 450.99 10.70 881 686427 195571 63615853
Glossodynia 448.31 10.70 75 687233 64621 63746803
Pain 446.01 10.70 3766 683542 549745 63261679
Syncope 419.74 10.70 2998 684310 154637 63656787
Systemic lupus erythematosus 406.19 10.70 159 687149 77453 63733971
Orthostatic hypotension 399.64 10.70 1251 686057 45487 63765937
Injection site pain 398.12 10.70 360 686948 111048 63700376
Right ventricular failure 397.09 10.70 773 686535 20698 63790726
Cardiac failure chronic 392.10 10.70 483 686825 8558 63802866
Hypervolaemia 377.76 10.70 1078 686230 37207 63774217
Lactic acidosis 377.00 10.70 1473 685835 59937 63751487
Musculoskeletal stiffness 376.28 10.70 455 686853 122751 63688673
Hypoglycaemia 375.01 10.70 1922 685386 87970 63723454
Pulmonary oedema 362.20 10.70 1730 685578 76944 63734480
Hepatic encephalopathy 356.70 10.70 731 686577 20335 63791089
Rash 354.69 10.70 3152 684156 455397 63356027
Rheumatoid factor positive 341.63 10.70 6 687302 34932 63776492
Chronic kidney disease 340.82 10.70 1371 685937 56548 63754876
Sinusitis 333.43 10.70 656 686652 145272 63666152
Toxicity to various agents 331.60 10.70 2389 684919 361124 63450300
Injection site erythema 331.37 10.70 170 687138 70630 63740794
Pericarditis 330.57 10.70 126 687182 62390 63749034
Ascites 329.89 10.70 1423 685885 60578 63750846
Abdominal discomfort 328.44 10.70 930 686378 181392 63630032
Product use issue 326.36 10.70 706 686602 151009 63660415
Pleural effusion 320.70 10.70 2379 684929 124180 63687244
Intentional overdose 314.99 10.70 296 687012 89648 63721776
Nasopharyngitis 310.84 10.70 1060 686248 195013 63616411
Duodenal ulcer perforation 293.70 10.70 19 687289 34606 63776818
Product use in unapproved indication 293.61 10.70 935 686373 175683 63635741
Therapeutic product effect incomplete 291.41 10.70 406 686902 103076 63708348
Hepatic enzyme increased 286.72 10.70 596 686712 129347 63682077
Suicide attempt 285.48 10.70 204 687104 70803 63740621
Metabolic alkalosis 273.35 10.70 269 687039 3659 63807765
Helicobacter infection 269.05 10.70 43 687265 38319 63773105
Ventricular tachycardia 268.29 10.70 890 686418 33375 63778049
Injection site reaction 267.59 10.70 82 687226 46582 63764842
Torsade de pointes 264.39 10.70 577 686731 16786 63794638
Discomfort 257.31 10.70 289 687019 80589 63730835
Headache 242.62 10.70 4076 683232 525391 63286033
Intentional product use issue 240.75 10.70 403 686905 94961 63716463
Coronary artery disease 236.73 10.70 1270 686038 59163 63752261
Cardiac failure acute 235.20 10.70 531 686777 15813 63795611
Sleep disorder due to general medical condition, insomnia type 233.39 10.70 11 687297 26259 63785165
Fatigue 232.25 10.70 6142 681166 742588 63068836
Rectal haemorrhage 227.99 10.70 1278 686030 60539 63750885
Chronic obstructive pulmonary disease 222.36 10.70 1407 685901 69641 63741783
Urticaria 216.42 10.70 822 686486 146495 63664929
Orthopnoea 213.51 10.70 364 686944 8770 63802654
Injection site swelling 210.99 10.70 88 687220 41265 63770159
Dyspnoea exertional 208.20 10.70 1423 685885 72307 63739117
Exposure during pregnancy 206.66 10.70 317 686991 77358 63734066
Wound 206.47 10.70 309 686999 76168 63735256
Folliculitis 205.85 10.70 36 687272 30041 63781383
Hypovolaemia 201.89 10.70 484 686824 15002 63796422
Haematoma 200.59 10.70 1000 686308 45250 63766174
Muscle injury 196.21 10.70 25 687283 26412 63785012
Rhabdomyolysis 194.33 10.70 1655 685653 90071 63721353
Shock haemorrhagic 193.85 10.70 501 686807 16290 63795134
Cardioactive drug level increased 193.72 10.70 211 687097 3254 63808170
Psoriatic arthropathy 193.63 10.70 110 687198 43171 63768253
Generalised oedema 192.08 10.70 573 686735 20280 63791144
Febrile neutropenia 190.44 10.70 1194 686114 186463 63624961
Respiratory failure 189.90 10.70 2585 684723 158598 63652826
Gastrointestinal disorder 185.83 10.70 426 686882 89283 63722141
Injection site pruritus 181.23 10.70 88 687220 37738 63773686
Nausea 178.80 10.70 6713 680595 779087 63032337
Suicidal ideation 177.56 10.70 271 687037 66271 63745153
Urine output decreased 177.10 10.70 479 686829 16013 63795411
Abortion spontaneous 174.49 10.70 29 687279 25114 63786310
Irritable bowel syndrome 172.95 10.70 91 687217 37278 63774146
Acute myocardial infarction 172.78 10.70 1304 686004 68414 63743010
Blood potassium increased 172.43 10.70 639 686669 25341 63786083
Injection site bruising 169.19 10.70 88 687220 36285 63775139
Renal injury 168.57 10.70 451 686857 14978 63796446
Mitral valve incompetence 167.72 10.70 626 686682 24912 63786512
Device expulsion 166.95 10.70 16 687292 21120 63790304
Stomatitis 165.89 10.70 604 686704 109001 63702423
Neutropenia 164.04 10.70 1696 685612 237928 63573496
Hypernatraemia 162.18 10.70 384 686924 11805 63799619
Infection 160.14 10.70 1232 686076 183648 63627776
Creatinine renal clearance decreased 159.03 10.70 423 686885 13998 63797426
N-terminal prohormone brain natriuretic peptide increased 158.97 10.70 193 687115 3366 63808058
Gout 157.76 10.70 545 686763 20868 63790556
Multiple sclerosis relapse 154.08 10.70 127 687181 41008 63770416
Cardiogenic shock 153.48 10.70 719 686589 31708 63779716
Cardiomegaly 152.58 10.70 577 686731 23107 63788317
Pyrexia 151.61 10.70 4666 682642 553978 63257446
Electrocardiogram QT prolonged 151.52 10.70 1401 685907 78047 63733377
Haemoglobin decreased 151.24 10.70 2919 684389 192144 63619280
Red blood cell sedimentation rate abnormal 147.58 10.70 6 687302 16300 63795124
Brain natriuretic peptide increased 146.26 10.70 279 687029 7354 63804070
Sopor 142.83 10.70 661 686647 29000 63782424
Asthenia 141.90 10.70 5741 681567 422303 63389121
Presyncope 140.52 10.70 742 686566 34347 63777077
Transfusion 137.84 10.70 464 686844 17530 63793894
Hepatic failure 137.76 10.70 1037 686271 54357 63757067
Hypoxia 137.45 10.70 1491 685817 86658 63724766
Pneumonia 135.46 10.70 7272 680036 552304 63259120
Anuria 133.95 10.70 476 686832 18488 63792936
Intentional product misuse 131.36 10.70 367 686941 71928 63739496
Blood pressure decreased 129.35 10.70 1447 685861 84752 63726672
Cardiac disorder 128.87 10.70 1027 686281 54789 63756635
Acute pulmonary oedema 127.61 10.70 362 686946 12447 63798977
Ischaemic cardiomyopathy 127.42 10.70 247 687061 6591 63804833
Accidental exposure to product 122.30 10.70 64 687244 26300 63785124
Impaired healing 119.78 10.70 294 687014 60179 63751245
Blood potassium decreased 118.98 10.70 788 686520 39611 63771813
C-reactive protein abnormal 118.64 10.70 82 687226 28965 63782459
Ejection fraction decreased 117.68 10.70 611 686697 28096 63783328
Pregnancy 117.23 10.70 38 687270 20827 63790597
Nephrocalcinosis 117.19 10.70 104 687204 1230 63810194
Epistaxis 116.80 10.70 1577 685731 96554 63714870
Mucosal inflammation 116.47 10.70 314 686994 62270 63749154
Multiple organ dysfunction syndrome 115.52 10.70 1617 685691 99796 63711628
Pseudo-Bartter syndrome 115.46 10.70 38 687270 26 63811398
Drug resistance 115.41 10.70 122 687186 34980 63776444
Hypocalcaemia 114.38 10.70 800 686508 40953 63770471
Tricuspid valve incompetence 114.33 10.70 420 686888 16583 63794841
Ill-defined disorder 114.09 10.70 183 687125 43869 63767555
Paraesthesia 113.84 10.70 902 686406 133620 63677804
Hypoaesthesia 113.48 10.70 942 686366 138166 63673258
Loss of personal independence in daily activities 112.45 10.70 395 686913 72059 63739365
Atrioventricular block 111.46 10.70 331 686977 11684 63799740
Pemphigoid 111.34 10.70 348 686960 12638 63798786
Psychotic disorder 110.56 10.70 123 687185 34455 63776969
Anaphylactic reaction 108.82 10.70 371 686937 68293 63743131
Inappropriate schedule of product administration 108.21 10.70 560 686748 91726 63719698
Subdural haematoma 108.09 10.70 587 686721 27467 63783957
Red blood cell sedimentation rate increased 106.74 10.70 105 687203 31130 63780294
Toxic epidermal necrolysis 106.48 10.70 720 686588 36446 63774978
Drug ineffective for unapproved indication 106.00 10.70 105 687203 31028 63780396
Swelling 105.10 10.70 1145 686163 159073 63652351
Hypomagnesaemia 104.66 10.70 720 686588 36656 63774768
Oliguria 103.92 10.70 367 686941 14209 63797215
Glomerular filtration rate decreased 103.89 10.70 449 686859 19123 63792301
Psoriasis 102.72 10.70 404 686904 71299 63740125
Gravitational oedema 102.64 10.70 107 687201 1565 63809859
Acute respiratory failure 102.59 10.70 895 686413 49039 63762385
Migraine 102.52 10.70 334 686974 62343 63749081
Haematemesis 102.14 10.70 853 686455 46146 63765278
Cardiomyopathy 102.09 10.70 537 686771 24819 63786605
Sleep disorder 101.30 10.70 313 686995 59396 63752028
Intentional self-injury 101.15 10.70 96 687212 28948 63782476
Insomnia 101.01 10.70 1491 685817 196345 63615079
Left ventricular failure 100.11 10.70 254 687054 8163 63803261
Congestive cardiomyopathy 99.81 10.70 289 687019 10055 63801369
Haematuria 99.47 10.70 1034 686274 59437 63751987
Pericardial effusion 98.81 10.70 737 686571 38517 63772907
Atrial flutter 98.62 10.70 439 686869 18941 63792483
Azotaemia 97.28 10.70 234 687074 7268 63804156
Immune reconstitution inflammatory syndrome 97.02 10.70 10 687298 12460 63798964
Arrhythmia 94.15 10.70 920 686388 52024 63759400
Rheumatoid nodule 93.79 10.70 12 687296 12639 63798785
Lower respiratory tract infection 92.83 10.70 608 686700 94006 63717418
Aortic stenosis 91.80 10.70 207 687101 6158 63805266
Rales 91.55 10.70 363 686945 14866 63796558
Seizure 90.75 10.70 1242 686066 165650 63645774
Infective pulmonary exacerbation of cystic fibrosis 90.40 10.70 10 687298 11786 63799638
Haematotoxicity 89.21 10.70 15 687293 12881 63798543
Blood loss anaemia 89.11 10.70 338 686970 13554 63797870
Coronary artery bypass 88.25 10.70 193 687115 5622 63805802
Hyperuricaemia 86.36 10.70 272 687036 9919 63801505
Atrioventricular block complete 86.14 10.70 343 686965 14075 63797349
Tenosynovitis 85.88 10.70 12 687296 11821 63799603
Haemodialysis 85.51 10.70 385 686923 16692 63794732
Product dose omission issue 84.71 10.70 1512 685796 193235 63618189
Bradyarrhythmia 84.21 10.70 147 687161 3611 63807813
Cerebrovascular accident 83.69 10.70 1988 685320 135595 63675829
Depression 83.27 10.70 1412 685896 181879 63629545
Adverse drug reaction 83.17 10.70 230 687078 45234 63766190
Night sweats 83.15 10.70 161 687147 35885 63775539
Oropharyngeal pain 82.73 10.70 580 686728 88287 63723137
Hip arthroplasty 82.36 10.70 64 687244 21287 63790137
Hepatic cirrhosis 82.36 10.70 521 686787 25777 63785647
Musculoskeletal pain 82.00 10.70 518 686790 80776 63730648
Iron deficiency anaemia 81.64 10.70 454 686854 21435 63789989
Hypochloraemia 81.25 10.70 105 687203 1956 63809468
Pruritus 80.44 10.70 2626 684682 309774 63501650
Device issue 79.88 10.70 74 687234 22574 63788850
Arthritis 79.52 10.70 544 686764 83270 63728154
Rheumatic fever 79.11 10.70 5 687303 9289 63802135
Upper gastrointestinal haemorrhage 79.09 10.70 644 686664 34576 63776848
Cardiac output decreased 78.72 10.70 94 687214 1610 63809814
Fear 78.34 10.70 423 686885 19748 63791676
Impaired work ability 78.25 10.70 32 687276 15187 63796237
Serotonin syndrome 77.77 10.70 191 687117 39091 63772333
Haemoptysis 77.06 10.70 831 686477 48217 63763207
Knee arthroplasty 76.89 10.70 105 687203 26894 63784530
Therapeutic response decreased 76.70 10.70 291 687017 51897 63759527
Dialysis 76.31 10.70 370 686938 16550 63794874
Myocardial ischaemia 76.17 10.70 466 686842 22785 63788639
Ventricular fibrillation 76.15 10.70 475 686833 23385 63788039
Concomitant disease aggravated 75.84 10.70 283 687025 11259 63800165
Jugular vein distension 74.77 10.70 81 687227 1241 63810183
Confusional state 74.59 10.70 3450 683858 257694 63553730
Blood pressure fluctuation 74.46 10.70 292 687016 51579 63759845
Venous pressure jugular increased 74.28 10.70 79 687229 1184 63810240
Colitis ulcerative 73.53 10.70 82 687226 22946 63788478
Cardiac arrest 73.44 10.70 2156 685152 151908 63659516
Poisoning 73.10 10.70 75 687233 21804 63789620
Respiratory distress 72.45 10.70 865 686443 51466 63759958
Bundle branch block left 71.84 10.70 253 687055 9781 63801643
Polyuria 71.73 10.70 296 687012 12347 63799077
Uveitis 71.65 10.70 23 687285 12685 63798739
Blood calcium decreased 71.38 10.70 492 686816 25062 63786362
Injection site warmth 71.37 10.70 27 687281 13435 63797989
Toxic skin eruption 71.28 10.70 399 686909 18885 63792539
Progressive multifocal leukoencephalopathy 71.16 10.70 54 687254 18178 63793246
Pulmonary arterial pressure increased 71.05 10.70 144 687164 3972 63807452
Neuropathy peripheral 70.76 10.70 856 686452 116669 63694755
Unevaluable event 70.54 10.70 836 686472 49653 63761771
Wrong technique in product usage process 70.26 10.70 405 686903 64569 63746855
Blood sodium decreased 69.98 10.70 546 686762 28936 63782488
Lower gastrointestinal haemorrhage 69.61 10.70 314 686994 13625 63797799
Death 69.24 10.70 6007 681301 476698 63334726
Oral herpes 68.43 10.70 81 687227 22071 63789353
Injection site rash 67.60 10.70 42 687266 15700 63795724
Ischaemic stroke 67.42 10.70 535 686773 28500 63782924
Cardiac murmur 67.41 10.70 273 687035 11290 63800134
Anhedonia 67.14 10.70 307 687001 13399 63798025
Blood bilirubin increased 66.86 10.70 921 686387 56632 63754792
Joint stiffness 66.55 10.70 140 687168 30264 63781160
Congestive hepatopathy 66.23 10.70 137 687171 3836 63807588
Prerenal failure 65.76 10.70 121 687187 3101 63808323
Concomitant disease progression 65.76 10.70 122 687186 3147 63808277
Therapeutic response shortened 65.73 10.70 14 687294 10156 63801268
Bone erosion 65.35 10.70 21 687287 11574 63799850
Hypoglycaemic coma 65.03 10.70 142 687166 4132 63807292
Left ventricular dysfunction 64.81 10.70 354 686954 16600 63794824
Grip strength decreased 64.73 10.70 22 687286 11702 63799722
Aortic valve incompetence 64.42 10.70 215 687093 8086 63803338
Sedation complication 64.02 10.70 249 687059 10105 63801319
Prothrombin time prolonged 63.80 10.70 334 686974 15407 63796017
Back pain 63.63 10.70 2106 685202 248065 63563359
Throat irritation 63.24 10.70 161 687147 32550 63778874
International normalised ratio decreased 62.82 10.70 199 687109 7279 63804145
Dilatation ventricular 62.82 10.70 132 687176 3738 63807686
Anxiety 62.21 10.70 1663 685645 200986 63610438
Oesophageal varices haemorrhage 61.51 10.70 126 687182 3503 63807921
Irritability 61.35 10.70 194 687114 36552 63774872
Drug withdrawal syndrome 60.50 10.70 154 687154 31137 63780287
Asthma 60.24 10.70 686 686622 94539 63716885
Suspected suicide 60.01 10.70 10 687298 8644 63802780
Injection site urticaria 59.99 10.70 22 687286 11159 63800265
Acne 59.65 10.70 96 687212 22985 63788439
Cellulitis 59.61 10.70 1362 685946 92295 63719129
Basal cell carcinoma 59.44 10.70 152 687156 30686 63780738
Vitamin B1 deficiency 58.63 10.70 49 687259 531 63810893
Electrolyte imbalance 58.54 10.70 465 686843 24778 63786646
Hyponatraemic syndrome 58.28 10.70 55 687253 708 63810716
Dystonia 58.26 10.70 69 687239 18796 63792628
Muscle spasticity 58.16 10.70 55 687253 16614 63794810
Foot deformity 58.12 10.70 54 687254 16450 63794974
Tendonitis 57.63 10.70 79 687229 20203 63791221
Malignant neoplasm progression 57.44 10.70 851 686457 112020 63699404
Cor pulmonale 57.28 10.70 88 687220 1937 63809487
Neoplasm progression 56.65 10.70 234 687074 40730 63770694
Device difficult to use 56.56 10.70 17 687291 9781 63801643
Dilatation atrial 56.38 10.70 118 687190 3332 63808092
Unintentional medical device removal 56.21 10.70 4 687304 6730 63804694
Vascular purpura 56.00 10.70 99 687209 2457 63808967
Pulmonary congestion 55.99 10.70 441 686867 23439 63787985
Eosinophilia 55.65 10.70 636 686672 37440 63773984
COVID-19 55.44 10.70 436 686872 64704 63746720
Blood pressure increased 55.07 10.70 1408 685900 171144 63640280
Cytomegalovirus infection 54.94 10.70 207 687101 36992 63774432
Dry eye 54.43 10.70 145 687163 28874 63782550
Generalised tonic-clonic seizure 54.29 10.70 229 687079 39628 63771796
Neutrophil count decreased 54.12 10.70 543 686765 76653 63734771
Aggression 53.92 10.70 281 687027 45951 63765473
Injection site haemorrhage 53.80 10.70 111 687197 24167 63787257
Dyspnoea paroxysmal nocturnal 53.77 10.70 85 687223 1919 63809505
Live birth 53.77 10.70 26 687282 11178 63800246
Ovarian cyst 53.75 10.70 25 687283 10993 63800431
Diastolic dysfunction 53.71 10.70 212 687096 8663 63802761
Injection site mass 53.51 10.70 63 687245 17207 63794217
Erythema 53.34 10.70 1551 685757 185519 63625905
Hypovolaemic shock 53.33 10.70 234 687074 10032 63801392
Depressed level of consciousness 53.30 10.70 1189 686119 80247 63731177
Head injury 53.25 10.70 560 686748 32282 63779142
Cerebral haemorrhage 53.15 10.70 802 686506 50288 63761136
Blood parathyroid hormone decreased 52.23 10.70 8 687300 7358 63804066
Substance abuse 52.07 10.70 17 687291 9275 63802149
Acute graft versus host disease 52.00 10.70 16 687292 9068 63802356
Influenza like illness 51.58 10.70 415 686893 61287 63750137
Herpes zoster 51.45 10.70 567 686741 78620 63732804
Fear of injection 50.87 10.70 3 687305 5909 63805515
Poor venous access 50.78 10.70 35 687273 12382 63799042
Drug dependence 50.75 10.70 183 687125 33129 63778295
Faeces discoloured 50.69 10.70 457 686851 25272 63786152
Inflammation 50.18 10.70 449 686859 64851 63746573
Microcytic anaemia 50.08 10.70 135 687173 4503 63806921
Muscle haemorrhage 50.08 10.70 155 687153 5598 63805826
Paradoxical drug reaction 50.05 10.70 4 687304 6116 63805308
Immunodeficiency 49.76 10.70 59 687249 16065 63795359
International normalised ratio abnormal 49.72 10.70 141 687167 4847 63806577
Nephrotic syndrome 49.65 10.70 218 687090 9349 63802075
Eye pain 49.34 10.70 172 687136 31453 63779971
Metabolic acidosis 49.31 10.70 1045 686263 69913 63741511
Ventricular extrasystoles 49.26 10.70 338 686970 17191 63794233
Pathogen resistance 49.15 10.70 37 687271 12506 63798918
Exercise tolerance decreased 48.97 10.70 187 687121 7523 63803901
Sudden death 48.71 10.70 374 686934 19722 63791702
Visual impairment 48.69 10.70 529 686779 73548 63737876
Mood swings 48.68 10.70 69 687239 17399 63794025
Pain in extremity 48.61 10.70 2687 684621 300398 63511026
Blood creatine increased 48.23 10.70 194 687114 7998 63803426
Bone density decreased 47.90 10.70 23 687285 9929 63801495
Sinus node dysfunction 47.89 10.70 171 687137 6657 63804767
Lymphadenopathy 47.83 10.70 296 687012 46390 63765034
Blood uric acid increased 47.80 10.70 193 687115 7970 63803454
Neutropenic sepsis 47.78 10.70 111 687197 23161 63788263
Schizophrenia 47.67 10.70 30 687278 11138 63800286
Osteoarthritis 47.58 10.70 438 686870 62898 63748526
Uterine perforation 47.06 10.70 4 687304 5816 63805608
Blood alkaline phosphatase increased 46.93 10.70 852 686456 55427 63755997
Cataract 46.52 10.70 337 686971 50925 63760499
Chest pain 46.41 10.70 3012 684296 232968 63578456
Abdominal pain 46.37 10.70 2790 684518 309585 63501839
Depressed mood 46.31 10.70 252 687056 40760 63770664
Ankylosing spondylitis 46.25 10.70 15 687293 8219 63803205
Multiple sclerosis 45.99 10.70 82 687226 18859 63792565
Gastrointestinal tract mucosal pigmentation 45.92 10.70 53 687255 874 63810550
Therapy partial responder 45.90 10.70 26 687282 10222 63801202
Hepatotoxicity 45.43 10.70 245 687063 39717 63771707
Exposure to toxic agent 45.28 10.70 6 687302 6153 63805271
Hepatocellular carcinoma 44.77 10.70 193 687115 8210 63803214
Gestational diabetes 44.77 10.70 4 687304 5586 63805838
Neck pain 44.74 10.70 429 686879 61104 63750320
Colitis 44.40 10.70 405 686903 58269 63753155
Coeliac disease 44.38 10.70 12 687296 7400 63804024
Ventricular dysfunction 44.05 10.70 140 687168 5130 63806294
Medication error 44.00 10.70 763 686545 49203 63762221
Low cardiac output syndrome 43.73 10.70 48 687260 747 63810677
Device use error 43.73 10.70 8 687300 6463 63804961
Photophobia 43.69 10.70 73 687235 17220 63794204
Hepatic cancer 43.54 10.70 176 687132 7272 63804152
Osteoporosis 43.01 10.70 267 687041 41813 63769611
Chills 43.00 10.70 1123 686185 136141 63675283
Feeling abnormal 42.93 10.70 1089 686219 132513 63678911
Coronary arterial stent insertion 42.91 10.70 146 687162 5546 63805878
Hypercalciuria 42.57 10.70 36 687272 397 63811027
Hypocoagulable state 42.20 10.70 73 687235 1780 63809644
Musculoskeletal disorder 42.15 10.70 79 687229 17827 63793597
Product storage error 41.89 10.70 48 687260 13270 63798154
Encephalopathy 41.77 10.70 869 686439 57950 63753474
Neuroleptic malignant syndrome 41.70 10.70 132 687176 24864 63786560
Nightmare 41.61 10.70 102 687206 20891 63790533
Bone pain 41.61 10.70 316 686992 47256 63764168
Abdominal wall haematoma 41.27 10.70 120 687188 4185 63807239
Acute graft versus host disease in skin 41.23 10.70 11 687297 6844 63804580
Renal disorder 40.69 10.70 565 686743 34800 63776624
Nodule 40.67 10.70 81 687227 17866 63793558
Breast cancer 40.62 10.70 166 687142 28982 63782442
Hepatorenal syndrome 40.41 10.70 109 687199 3637 63807787
Blood cholesterol increased 40.36 10.70 340 686968 49726 63761698
Myelosuppression 40.35 10.70 125 687183 23705 63787719
Blister 40.31 10.70 613 686695 80354 63731070
Crying 40.30 10.70 97 687211 19993 63791431
White blood cell count decreased 40.26 10.70 1328 685980 156509 63654915
Post transplant lymphoproliferative disorder 40.24 10.70 26 687282 9518 63801906
Tuberculosis 39.93 10.70 48 687260 12990 63798434
Cardiac valve disease 39.82 10.70 134 687174 5061 63806363
Diabetic ketoacidosis 39.72 10.70 173 687135 29672 63781752
Occult blood positive 39.53 10.70 152 687156 6135 63805289
Dermatitis exfoliative 39.46 10.70 216 687092 10136 63801288
Upper respiratory tract infection 39.41 10.70 542 686766 72243 63739181
Pericardial haemorrhage 39.37 10.70 115 687193 4021 63807403
Sepsis 39.33 10.70 2906 684402 227435 63583989
Nephrolithiasis 39.24 10.70 288 687020 43395 63768029
Atrioventricular block first degree 38.94 10.70 221 687087 10513 63800911
Activated partial thromboplastin time prolonged 38.82 10.70 252 687056 12579 63798845
Muscle twitching 38.69 10.70 91 687217 18907 63792517
Poisoning deliberate 38.66 10.70 52 687256 13406 63798018
Ischaemic hepatitis 38.65 10.70 98 687210 3148 63808276
Catheter management 38.61 10.70 100 687208 3255 63808169
Ecchymosis 38.59 10.70 269 687039 13753 63797671
Appendicitis 38.41 10.70 53 687255 13516 63797908
Subcutaneous haematoma 38.35 10.70 83 687225 2400 63809024
Bursitis 38.33 10.70 110 687198 21375 63790049
Vascular graft 38.17 10.70 70 687238 1789 63809635
Device dislocation 38.09 10.70 108 687200 21070 63790354
Multiple-drug resistance 38.05 10.70 11 687297 6491 63804933
Fibromyalgia 37.94 10.70 224 687084 35507 63775917
Cardiorenal syndrome 37.74 10.70 56 687252 1194 63810230
Hypercreatininaemia 37.72 10.70 45 687263 770 63810654
Angina unstable 37.57 10.70 288 687020 15179 63796245
Pseudoporphyria 37.50 10.70 37 687271 505 63810919
Respiratory arrest 37.43 10.70 372 686936 52613 63758811
Sinus bradycardia 37.42 10.70 391 686917 22502 63788922
Abdominal pain upper 37.35 10.70 1505 685803 173525 63637899
Peripartum cardiomyopathy 37.33 10.70 21 687287 110 63811314
Intra-abdominal haematoma 37.30 10.70 82 687226 2397 63809027
Drug tolerance decreased 37.16 10.70 14 687294 6984 63804440
Cardiac pacemaker insertion 37.13 10.70 128 687180 4895 63806529
Disability 37.07 10.70 45 687263 12127 63799297
Hepatic function abnormal 36.88 10.70 922 686386 63391 63748033
Mucormycosis 36.84 10.70 16 687292 7325 63804099
Hypercapnia 36.69 10.70 171 687137 7523 63803901
Dyspnoea at rest 36.56 10.70 149 687159 6180 63805244
Mania 36.48 10.70 74 687234 16212 63795212
Arteriospasm coronary 36.41 10.70 7 687301 5458 63805966
Panniculitis 36.35 10.70 25 687283 8854 63802570
Plasma cell myeloma 36.15 10.70 691 686617 45384 63766040
Haemophagocytic lymphohistiocytosis 36.14 10.70 84 687224 17525 63793899
Paranoia 36.03 10.70 75 687233 16277 63795147
Impaired quality of life 35.98 10.70 12 687296 6459 63804965
No adverse event 35.94 10.70 169 687139 28392 63783032
Central nervous system lesion 35.89 10.70 44 687264 11805 63799619
Pelvic pain 35.77 10.70 38 687270 10872 63800552
Blood creatinine abnormal 35.75 10.70 111 687197 4016 63807408
Osteonecrosis of jaw 35.56 10.70 263 687045 39562 63771862
Nodal rhythm 35.51 10.70 88 687220 2786 63808638
Feeling hot 35.51 10.70 313 686995 45350 63766074
Hyperhidrosis 35.27 10.70 1037 686271 123883 63687541
Normochromic normocytic anaemia 35.14 10.70 153 687155 6537 63804887
Ear pain 35.12 10.70 143 687165 24993 63786431
Abnormal behaviour 35.05 10.70 212 687096 33410 63778014
Oxygen consumption increased 34.97 10.70 118 687190 4463 63806961
Mydriasis 34.79 10.70 69 687239 15243 63796181
Throat tightness 34.77 10.70 128 687180 23032 63788392
Device interaction 34.73 10.70 40 687268 658 63810766
Ear infection 34.71 10.70 130 687178 23274 63788150
Influenza 34.58 10.70 867 686441 105664 63705760
Peritonitis bacterial 34.01 10.70 188 687120 8855 63802569
Loss of consciousness 33.88 10.70 1919 685389 146446 63664978
Anal abscess 33.69 10.70 19 687289 7489 63803935
Pharyngitis 33.58 10.70 98 687210 18941 63792483
Tongue disorder 33.38 10.70 48 687260 12032 63799392
Bone marrow failure 33.31 10.70 338 686970 47614 63763810
Frequent bowel movements 33.18 10.70 93 687215 18212 63793212
Nephrogenic anaemia 33.15 10.70 94 687214 3231 63808193
Gastritis erosive 33.15 10.70 195 687113 9400 63802024
Polyomavirus-associated nephropathy 33.12 10.70 6 687302 4882 63806542
Dermatitis bullous 33.03 10.70 231 687077 11823 63799601
Tooth infection 33.00 10.70 66 687242 14535 63796889
Emotional disorder 32.99 10.70 52 687256 12555 63798869
Mood altered 32.97 10.70 76 687232 15903 63795521
Chronic graft versus host disease 32.59 10.70 13 687295 6263 63805161
Tachyarrhythmia 32.56 10.70 139 687169 5887 63805537
Overdose 32.56 10.70 1379 685929 158187 63653237
Amnesia 32.40 10.70 343 686965 47926 63763498
Muscle spasms 32.40 10.70 1202 686106 139821 63671603
Tardive dyskinesia 32.35 10.70 30 687278 9148 63802276
Angina pectoris 32.32 10.70 667 686641 44414 63767010
Arteriosclerosis 32.30 10.70 284 687024 15593 63795831
Anticoagulation drug level above therapeutic 32.25 10.70 88 687220 2957 63808467
Epstein-Barr virus infection 32.22 10.70 52 687256 12436 63798988
Memory impairment 32.11 10.70 682 686626 85000 63726424
Gastric disorder 32.09 10.70 181 687127 29016 63782408
Hypersensitivity vasculitis 32.05 10.70 150 687158 6611 63804813
Acrodermatitis enteropathica 31.97 10.70 9 687299 0 63811424
Middle insomnia 31.94 10.70 55 687253 12822 63798602
Ventricular arrhythmia 31.91 10.70 160 687148 7255 63804169
Incorrect route of product administration 31.64 10.70 134 687174 23164 63788260
Coagulopathy 31.64 10.70 497 686811 31423 63780001
Troponin increased 31.61 10.70 276 687032 15123 63796301
Mouth ulceration 31.55 10.70 209 687099 32235 63779189
Spontaneous haematoma 31.50 10.70 52 687256 1219 63810205
Left ventricular dilatation 31.43 10.70 44 687264 888 63810536
Gouty arthritis 31.31 10.70 53 687255 1269 63810155
Drug reaction with eosinophilia and systemic symptoms 31.30 10.70 778 686530 53439 63757985
Disturbance in attention 31.30 10.70 283 687025 40791 63770633
Metastases to bone 31.30 10.70 112 687196 20323 63791101
Illness 31.16 10.70 124 687184 21814 63789610
Ocular hyperaemia 31.13 10.70 129 687179 22435 63788989
Sexual dysfunction 31.08 10.70 15 687293 6456 63804968
Heparin-induced thrombocytopenia 31.04 10.70 175 687133 8304 63803120
Product quality issue 31.01 10.70 188 687120 29611 63781813
Anger 30.79 10.70 77 687231 15664 63795760
Graft versus host disease 30.74 10.70 63 687245 13750 63797674
Extrapyramidal disorder 30.72 10.70 106 687202 19446 63791978
Vomiting 30.70 10.70 5285 682023 545832 63265592
Malignant melanoma 30.69 10.70 57 687251 12907 63798517
Bundle branch block right 30.65 10.70 201 687107 10068 63801356
Hyperaesthesia 30.52 10.70 37 687271 9977 63801447
Paracentesis 30.52 10.70 51 687257 1208 63810216
Juvenile idiopathic arthritis 30.47 10.70 3 687305 3876 63807548
Myoclonus 30.41 10.70 405 686903 24713 63786711
Tachycardia 30.24 10.70 1294 686014 148285 63663139
Rhinorrhoea 30.20 10.70 453 686855 59516 63751908
Burning sensation 30.15 10.70 361 686947 49303 63762121
Abdominal cavity drainage 30.01 10.70 38 687270 693 63810731
Neuromyopathy 29.99 10.70 53 687255 1315 63810109
Cholestasis 29.94 10.70 657 686651 44215 63767209
Asterixis 29.88 10.70 73 687235 2290 63809134
Myopathy 29.86 10.70 304 687004 17376 63794048
Pharyngitis streptococcal 29.78 10.70 29 687279 8639 63802785
Vision blurred 29.59 10.70 734 686574 89582 63721842
Superinfection 29.58 10.70 100 687208 3786 63807638
Mental disorder 29.58 10.70 163 687145 26282 63785142
C-reactive protein increased 29.58 10.70 777 686531 94132 63717292
Neurotoxicity 29.52 10.70 171 687137 27233 63784191
Shock 29.49 10.70 572 686736 37668 63773756
Hot flush 29.26 10.70 333 686975 45902 63765522
Atrial tachycardia 29.25 10.70 94 687214 3465 63807959
Jaundice 29.17 10.70 700 686608 47812 63763612
Hepatitis B reactivation 29.11 10.70 8 687300 4881 63806543
Temperature regulation disorder 28.90 10.70 5 687303 4206 63807218
Diabetes mellitus inadequate control 28.88 10.70 351 686957 20970 63790454
Menstruation irregular 28.88 10.70 6 687302 4429 63806995
Oxygen saturation decreased 28.85 10.70 1408 685900 105768 63705656
Cerebral haematoma 28.80 10.70 152 687156 7033 63804391
Hypophagia 28.80 10.70 587 686721 39000 63772424
Urinary tract discomfort 28.73 10.70 26 687282 316 63811108
Alanine aminotransferase abnormal 28.72 10.70 19 687289 6869 63804555
Haemorrhage subcutaneous 28.71 10.70 107 687201 4254 63807170
Amenorrhoea 28.70 10.70 17 687291 6522 63804902
Heavy menstrual bleeding 28.68 10.70 53 687255 12024 63799400
Blood albumin decreased 28.58 10.70 347 686961 20726 63790698
Second primary malignancy 28.54 10.70 55 687253 12282 63799142
Withdrawal syndrome 28.40 10.70 141 687167 23351 63788073
Laryngitis 28.39 10.70 46 687262 10985 63800439
Fungal infection 28.33 10.70 231 687077 34020 63777404
Intraocular pressure increased 28.26 10.70 28 687280 8274 63803150
Varices oesophageal 28.24 10.70 119 687189 5011 63806413
Metastases to liver 28.20 10.70 145 687163 23796 63787628
Sudden cardiac death 28.11 10.70 110 687198 4477 63806947
Disturbance in social behaviour 28.07 10.70 4 687304 3883 63807541
Hypoalbuminaemia 28.01 10.70 300 687008 17374 63794050
Liver function test increased 27.90 10.70 204 687104 30766 63780658
Disorientation 27.87 10.70 786 686522 55042 63756382
Right ventricular dysfunction 27.80 10.70 68 687240 2135 63809289
Renal artery stenosis 27.73 10.70 82 687226 2887 63808537
Injection site induration 27.23 10.70 33 687275 8899 63802525
Disease recurrence 27.23 10.70 210 687098 31300 63780124
Left ventricular enlargement 27.21 10.70 35 687273 649 63810775
Renal tubular necrosis 26.98 10.70 357 686951 21753 63789671
Eye irritation 26.97 10.70 83 687225 15773 63795651
Brain natriuretic peptide abnormal 26.96 10.70 35 687273 655 63810769
Aspiration pleural cavity 26.94 10.70 52 687256 1383 63810041
Transplant rejection 26.90 10.70 95 687213 17306 63794118
Alcohol interaction 26.58 10.70 7 687301 4394 63807030
Accidental death 26.52 10.70 4 687304 3721 63807703
Body temperature increased 26.49 10.70 256 687052 36410 63775014
Joint range of motion decreased 26.43 10.70 111 687197 19232 63792192
Adverse event 26.35 10.70 281 687027 39208 63772216
Right atrial dilatation 26.33 10.70 35 687273 671 63810753
Pre-eclampsia 26.24 10.70 17 687291 6214 63805210
Drug specific antibody present 26.24 10.70 11 687297 5143 63806281
Cardiac amyloidosis 26.23 10.70 51 687257 1364 63810060
Ventricular hypertrophy 26.23 10.70 138 687170 6378 63805046
Drug use disorder 26.21 10.70 16 687292 6038 63805386
Catheter site infection 26.04 10.70 125 687183 5568 63805856
Nephrosclerosis 25.98 10.70 54 687254 1517 63809907
Circulatory collapse 25.82 10.70 504 686804 33228 63778196
Neuralgia 25.80 10.70 168 687140 26016 63785408
Cholecystitis chronic 25.57 10.70 37 687271 9250 63802174
Ulcer 25.55 10.70 142 687166 22848 63788576
Blood lactic acid 25.55 10.70 28 687280 435 63810989
Syringe issue 25.54 10.70 7 687301 4279 63807145
Ammonia increased 25.54 10.70 144 687164 6833 63804591
Alkalosis 25.42 10.70 27 687281 404 63811020
Foetal exposure during pregnancy 25.42 10.70 8 687300 4468 63806956
Respiratory depression 25.40 10.70 146 687162 23297 63788127
Acute generalised exanthematous pustulosis 25.33 10.70 245 687063 13813 63797611
Tachypnoea 25.31 10.70 411 686897 26160 63785264
Right atrial enlargement 25.30 10.70 24 687284 311 63811113
Endocarditis 25.27 10.70 179 687129 9199 63802225
Purpura 25.17 10.70 288 687020 16958 63794466
Synovial cyst 25.09 10.70 27 687281 7680 63803744
Complication of device insertion 25.03 10.70 11 687297 5001 63806423
Ventricular dyssynchrony 25.03 10.70 12 687296 42 63811382
Abscess 25.02 10.70 113 687195 19191 63792233
Weight decreased 24.99 10.70 2664 684644 283075 63528349
Right ventricular hypertrophy 24.98 10.70 48 687260 1272 63810152
Acute coronary syndrome 24.91 10.70 315 686993 18995 63792429
Pneumocystis jirovecii pneumonia 24.91 10.70 182 687126 27452 63783972
Gouty tophus 24.88 10.70 24 687284 318 63811106
Arteriosclerosis coronary artery 24.80 10.70 264 687044 15265 63796159
Demyelination 24.49 10.70 22 687286 6812 63804612
Haematoma muscle 24.41 10.70 57 687251 1736 63809688
Hypomania 24.40 10.70 15 687293 5639 63805785
Chronic respiratory failure 24.37 10.70 72 687236 2534 63808890
Akathisia 24.36 10.70 54 687254 11456 63799968
Cushingoid 24.35 10.70 27 687281 7576 63803848
Blood pressure diastolic abnormal 24.33 10.70 57 687251 11860 63799564
Agranulocytosis 24.33 10.70 556 686752 37673 63773751
Sciatica 24.29 10.70 122 687186 20142 63791282
Hepatitis B 24.27 10.70 28 687280 7717 63803707
Eyelid ptosis 24.26 10.70 40 687268 9485 63801939
Inflammatory bowel disease 24.23 10.70 9 687299 4529 63806895
Abdominal distension 24.17 10.70 1253 686055 94741 63716683
Blood pressure systolic decreased 24.15 10.70 169 687139 8651 63802773
Gastric varices 24.09 10.70 29 687279 501 63810923
Blood iron decreased 24.09 10.70 216 687092 11926 63799498
Alkalosis hypochloraemic 23.97 10.70 27 687281 433 63810991
Gastrointestinal vascular malformation haemorrhagic 23.86 10.70 33 687275 658 63810766
Atrial thrombosis 23.79 10.70 79 687229 2963 63808461
Haemorrhage intracranial 23.71 10.70 372 686936 23512 63787912
Atrial septal defect repair 23.70 10.70 25 687283 371 63811053
Long QT syndrome 23.62 10.70 113 687195 5026 63806398
Pregnancy with contraceptive device 23.56 10.70 3 687305 3171 63808253
Atrial enlargement 23.52 10.70 32 687276 628 63810796
Cyanosis 23.51 10.70 349 686959 21806 63789618
Hepatic steatosis 23.47 10.70 214 687094 30793 63780631
Duodenal ulcer haemorrhage 23.46 10.70 131 687177 6194 63805230
Mitral valve thickening 23.44 10.70 25 687283 376 63811048
Joint effusion 23.29 10.70 70 687238 13403 63798021
Blepharospasm 23.18 10.70 4 687304 3371 63808053
Salivary hypersecretion 23.12 10.70 60 687248 12053 63799371
Tooth abscess 23.07 10.70 73 687235 13753 63797671
Tremor 23.01 10.70 1318 685990 146912 63664512
Aspergillus infection 23.00 10.70 93 687215 16286 63795138
Caesarean section 22.96 10.70 54 687254 11220 63800204
Mitral valve disease 22.90 10.70 71 687237 2567 63808857
Gastrointestinal angiodysplasia 22.89 10.70 38 687270 895 63810529
Product substitution issue 22.88 10.70 105 687203 17756 63793668
Protein total decreased 22.88 10.70 154 687154 7782 63803642
Haematocrit decreased 22.87 10.70 753 686555 53902 63757522
Heart sounds abnormal 22.73 10.70 43 687265 1126 63810298
Catheter placement 22.70 10.70 70 687238 2523 63808901
Catheter site haemorrhage 22.61 10.70 103 687205 4488 63806936
Anal fistula 22.58 10.70 14 687294 5239 63806185
Haemoconcentration 22.54 10.70 15 687293 111 63811313
Colitis microscopic 22.50 10.70 146 687162 7286 63804138
Chronic hepatic failure 22.45 10.70 36 687272 823 63810601
Pulmonary hypertensive crisis 22.37 10.70 22 687286 299 63811125
Prothrombin time shortened 22.29 10.70 74 687234 2775 63808649
Balance disorder 22.26 10.70 1101 686207 82825 63728599
Septic shock 22.20 10.70 1354 685954 104083 63707341
Carpal tunnel syndrome 22.14 10.70 90 687218 15738 63795686
Metabolic encephalopathy 22.11 10.70 154 687154 7871 63803553
Oxygen therapy 22.06 10.70 64 687244 2229 63809195
Ventricular internal diameter abnormal 21.98 10.70 16 687292 139 63811285
Left ventricular hypertrophy 21.98 10.70 175 687133 9331 63802093
Graft versus host disease in skin 21.96 10.70 15 687293 5332 63806092
BK virus infection 21.95 10.70 28 687280 7384 63804040
Foot fracture 21.94 10.70 109 687199 18048 63793376
Virologic failure 21.94 10.70 5 687303 3461 63807963
Body temperature decreased 21.84 10.70 174 687134 25754 63785670
Dyspepsia 21.84 10.70 670 686638 79642 63731782
Alcohol poisoning 21.79 10.70 9 687299 4246 63807178
Mycobacterial infection 21.76 10.70 3 687305 2985 63808439
Diabetic nephropathy 21.72 10.70 70 687238 2584 63808840
Coagulation time prolonged 21.72 10.70 61 687247 2085 63809339
Lung transplant 21.61 10.70 94 687214 4014 63807410
Prostate cancer 21.60 10.70 123 687185 19672 63791752
Stillbirth 21.53 10.70 6 687302 3627 63807797
Affective disorder 21.48 10.70 23 687285 6557 63804867
Diplopia 21.46 10.70 182 687126 26583 63784841
Walking distance test abnormal 21.44 10.70 32 687276 686 63810738
Hyperparathyroidism secondary 21.43 10.70 64 687244 2266 63809158
Graft versus host disease in gastrointestinal tract 21.42 10.70 17 687291 5595 63805829
Cardio-respiratory arrest 21.37 10.70 1267 686041 97126 63714298
Anticoagulation drug level increased 21.34 10.70 31 687277 648 63810776
Retroperitoneal haematoma 21.23 10.70 103 687205 4608 63806816
Dry mouth 21.17 10.70 486 686822 59932 63751492
Cardiac cirrhosis 21.04 10.70 18 687290 202 63811222
Catheter site discharge 21.03 10.70 62 687246 2179 63809245
Diffuse large B-cell lymphoma recurrent 21.02 10.70 4 687304 3142 63808282
Anaphylactic shock 20.97 10.70 214 687094 30114 63781310
JC virus infection 20.92 10.70 5 687303 3350 63808074
Food allergy 20.91 10.70 32 687276 7819 63803605
Blood chloride decreased 20.84 10.70 143 687165 7273 63804151
Viral mutation identified 20.83 10.70 5 687303 3341 63808083
Antibiotic level above therapeutic 20.76 10.70 29 687279 584 63810840
Optic neuritis 20.74 10.70 34 687274 8082 63803342
Posterior reversible encephalopathy syndrome 20.74 10.70 151 687157 22795 63788629
Blood pressure diastolic increased 20.72 10.70 53 687255 10699 63800725
Hyperaldosteronism 20.70 10.70 23 687285 363 63811061
Decubitus ulcer 20.70 10.70 226 687082 13153 63798271
Transplant evaluation 20.66 10.70 49 687259 1508 63809916
Haemorrhage 20.63 10.70 1039 686269 78312 63733112
Blood prolactin increased 20.59 10.70 6 687302 3522 63807902
Scrotal oedema 20.57 10.70 42 687266 1165 63810259
Hypochromasia 20.55 10.70 30 687278 630 63810794
Subdural haemorrhage 20.45 10.70 111 687197 5192 63806232
Leukopenia 20.42 10.70 876 686432 100366 63711058
Hypercreatinaemia 20.42 10.70 19 687289 240 63811184
Peripheral arterial occlusive disease 20.39 10.70 136 687172 6851 63804573
Ovarian hyperstimulation syndrome 20.38 10.70 3 687305 2842 63808582
Pickwickian syndrome 20.36 10.70 23 687285 370 63811054
Premature labour 20.35 10.70 31 687277 7589 63803835
Rash pruritic 20.33 10.70 461 686847 56943 63754481
Tuberculin test positive 20.29 10.70 4 687304 3064 63808360
Electrocardiogram T wave peaked 20.24 10.70 34 687274 809 63810615
Hyperprolactinaemia 20.18 10.70 9 687299 4056 63807368
Pulmonary arterial pressure abnormal 20.17 10.70 30 687278 641 63810783
Catheterisation cardiac 20.16 10.70 104 687204 4769 63806655
Erectile dysfunction 20.15 10.70 68 687240 12559 63798865
Ataxia 20.12 10.70 145 687163 21939 63789485
Left atrial enlargement 20.12 10.70 38 687270 994 63810430
Right ventricular enlargement 20.09 10.70 26 687282 485 63810939
Ureteric rupture 20.09 10.70 7 687301 7 63811417
Cytomegalovirus infection reactivation 20.07 10.70 19 687289 5737 63805687
Anosognosia 19.99 10.70 3 687305 2802 63808622
Gastric ulcer haemorrhage 19.99 10.70 152 687156 7991 63803433
Gastric ulcer 19.95 10.70 442 686866 29792 63781632
Drug dose omission by device 19.95 10.70 6 687302 3451 63807973
Euglycaemic diabetic ketoacidosis 19.89 10.70 17 687291 5393 63806031
Cytomegalovirus chorioretinitis 19.88 10.70 14 687294 4898 63806526
Enuresis 19.85 10.70 3 687305 2787 63808637
Adverse reaction 19.84 10.70 32 687276 7655 63803769
Decreased appetite 19.83 10.70 3348 683960 277941 63533483
Granuloma 19.76 10.70 25 687283 6616 63804808
Right ventricular dilatation 19.74 10.70 46 687262 1399 63810025
Lupus-like syndrome 19.64 10.70 40 687268 8751 63802673
Hyperglycaemic hyperosmolar nonketotic syndrome 19.54 10.70 51 687257 1668 63809756
Surgery 19.54 10.70 199 687109 28014 63783410
Cardiovascular insufficiency 19.51 10.70 67 687241 2557 63808867
Cardioversion 19.49 10.70 54 687254 1831 63809593
Hypertrophic cardiomyopathy 19.47 10.70 54 687254 1832 63809592
Multimorbidity 19.40 10.70 37 687271 975 63810449
Priapism 19.38 10.70 9 687299 3961 63807463
Blood urea abnormal 19.37 10.70 41 687267 1167 63810257
Heart disease congenital 19.35 10.70 26 687282 504 63810920
Pulmonary vein stenosis 19.32 10.70 15 687293 145 63811279
Mitral valve stenosis 19.30 10.70 38 687270 1026 63810398
Nodal arrhythmia 19.26 10.70 53 687255 1790 63809634
Sensitivity to weather change 19.23 10.70 26 687282 6688 63804736
Chronic left ventricular failure 19.20 10.70 31 687277 713 63810711
Human herpesvirus 6 infection 19.19 10.70 13 687295 4641 63806783
Intervertebral disc protrusion 19.16 10.70 131 687177 20060 63791364
Maternal exposure timing unspecified 19.06 10.70 3 687305 2704 63808720
Lymphoedema 19.03 10.70 175 687133 9730 63801694
Penis injury 19.02 10.70 14 687294 124 63811300
Drug level decreased 19.01 10.70 61 687247 11442 63799982
Haemorrhagic diathesis 19.01 10.70 112 687196 5402 63806022
Aphthous ulcer 18.94 10.70 72 687236 12834 63798590
Incorrect dose administered by device 18.92 10.70 10 687298 4087 63807337
Skin weeping 18.91 10.70 28 687280 596 63810828
Urine calcium decreased 18.89 10.70 8 687300 19 63811405
Hepatitis fulminant 18.84 10.70 123 687185 6151 63805273
Muscle rigidity 18.84 10.70 109 687199 17364 63794060
Blood potassium abnormal 18.84 10.70 65 687243 2487 63808937
Amyloidosis 18.82 10.70 64 687244 2430 63808994
Paraesthesia oral 18.79 10.70 74 687234 13057 63798367
Bundle branch block 18.76 10.70 45 687263 1395 63810029
Electrocardiogram ST segment abnormal 18.70 10.70 42 687266 1246 63810178
Scleroderma 18.68 10.70 101 687207 4717 63806707
Lip dry 18.64 10.70 15 687293 4903 63806521
Mitral valve calcification 18.59 10.70 44 687264 1352 63810072
Therapeutic embolisation 18.58 10.70 24 687284 447 63810977
Haemorrhagic disorder 18.53 10.70 44 687264 1355 63810069
Degenerative aortic valve disease 18.53 10.70 13 687295 106 63811318
Rash maculo-papular 18.44 10.70 643 686665 46383 63765041
Aortic valve stenosis 18.43 10.70 97 687211 4483 63806941
Complication of device removal 18.38 10.70 6 687302 3274 63808150
Phlebitis deep 18.37 10.70 7 687301 11 63811413
Diabetic foot 18.36 10.70 72 687236 2933 63808491
Melanoderma 18.35 10.70 21 687287 343 63811081
Injection site discolouration 18.33 10.70 28 687280 6847 63804577
Hydrothorax 18.26 10.70 41 687267 1216 63810208
Erysipelas 18.25 10.70 162 687146 8919 63802505
Metastases to lung 18.23 10.70 92 687216 15172 63796252
Agitation 18.16 10.70 763 686545 87604 63723820
Alcohol abuse 18.14 10.70 15 687293 4837 63806587
Joint destruction 18.13 10.70 8 687300 3628 63807796
Joint dislocation 18.12 10.70 62 687246 11403 63800021
Device deployment issue 18.04 10.70 4 687304 2822 63808602
Herpes simplex 18.03 10.70 55 687253 10481 63800943
Hypokalaemic syndrome 17.99 10.70 11 687297 69 63811355
Scrotal swelling 17.93 10.70 34 687274 892 63810532
Lacrimation increased 17.93 10.70 118 687190 18228 63793196
Catheter site pruritus 17.90 10.70 57 687251 2091 63809333
Acute motor-sensory axonal neuropathy 17.85 10.70 22 687286 390 63811034
Tinnitus 17.82 10.70 256 687052 33877 63777547
Intestinal stenosis 17.80 10.70 6 687302 3208 63808216
Diffuse large B-cell lymphoma 17.79 10.70 54 687254 10307 63801117
Dermatitis exfoliative generalised 17.78 10.70 116 687192 5800 63805624
Oesophageal variceal ligation 17.76 10.70 13 687295 114 63811310
Oedema due to renal disease 17.76 10.70 5 687303 0 63811424
Tongue oedema 17.73 10.70 117 687191 5873 63805551
Blood bicarbonate increased 17.71 10.70 38 687270 1092 63810332
Lymphorrhoea 17.67 10.70 13 687295 115 63811309
Blood sodium increased 17.67 10.70 92 687216 4234 63807190
Hyperthyroidism 17.62 10.70 282 687026 17897 63793527
Lymphoproliferative disorder 17.61 10.70 17 687291 5086 63806338
Alveolar lung disease 17.59 10.70 25 687283 512 63810912
Affect lability 17.57 10.70 44 687264 8946 63802478
Hallucination, auditory 17.56 10.70 107 687201 16832 63794592
Cytomegalovirus colitis 17.54 10.70 10 687298 3918 63807506
Bronchopulmonary aspergillosis 17.54 10.70 125 687183 18960 63792464
Subarachnoid haemorrhage 17.49 10.70 285 687023 18153 63793271
Hypophysitis 17.48 10.70 8 687300 3551 63807873
Premature delivery 17.45 10.70 121 687187 18468 63792956
Continuous haemodiafiltration 17.41 10.70 53 687255 1897 63809527
Scleritis 17.39 10.70 5 687303 2961 63808463
Cardiopulmonary failure 17.35 10.70 119 687189 6051 63805373
Road traffic accident 17.34 10.70 227 687081 30518 63780906
Extrasystoles 17.32 10.70 126 687182 6532 63804892
Ketoacidosis 17.31 10.70 29 687279 6834 63804590
Seronegative arthritis 17.28 10.70 4 687304 2739 63808685
Hypochromic anaemia 17.20 10.70 60 687248 2308 63809116
Drug effective for unapproved indication 17.20 10.70 9 687299 3699 63807725
Erythromelalgia 17.13 10.70 15 687293 174 63811250
Sleep disorder due to a general medical condition 17.12 10.70 39 687269 8195 63803229
Type 2 diabetes mellitus 17.12 10.70 257 687051 33763 63777661
Peritoneal dialysis 17.12 10.70 29 687279 695 63810729
Status epilepticus 17.06 10.70 148 687160 21515 63789909
Hypothermia 17.04 10.70 302 687006 19554 63791870
Pulmonary tuberculosis 17.02 10.70 32 687276 7212 63804212
Lipodystrophy acquired 16.94 10.70 11 687297 4016 63807408
Sinus arrhythmia 16.86 10.70 51 687257 1819 63809605
Body temperature fluctuation 16.85 10.70 7 687301 3291 63808133
Emotional distress 16.79 10.70 503 686805 35535 63775889
Thrombocytopenic purpura 16.78 10.70 56 687252 2106 63809318
Catatonia 16.75 10.70 35 687273 7585 63803839
Fracture 16.67 10.70 124 687184 18631 63792793
Cardiac ablation 16.61 10.70 49 687259 1723 63809701
Brain natriuretic peptide 16.48 10.70 9 687299 44 63811380
Blood pressure systolic increased 16.44 10.70 401 686907 49052 63762372
Dermatitis allergic 16.42 10.70 94 687214 15015 63796409
Basilar artery occlusion 16.34 10.70 15 687293 186 63811238
Altered state of consciousness 16.32 10.70 524 686784 37378 63774046
Hypertensive heart disease 16.31 10.70 82 687226 3722 63807702
Bleeding varicose vein 16.29 10.70 23 687285 468 63810956
Eye infection 16.20 10.70 48 687260 9233 63802191
Heart transplant 16.20 10.70 39 687269 1212 63810212
Renal artery thrombosis 16.20 10.70 22 687286 431 63810993
Viral infection 16.19 10.70 279 687029 35861 63775563
Platelet count decreased 16.10 10.70 2032 685276 165679 63645745
Dysphagia 15.98 10.70 953 686355 105859 63705565
Cardiac rehabilitation therapy 15.91 10.70 6 687302 9 63811415
Intestinal haemorrhage 15.90 10.70 107 687201 5407 63806017
Cystitis 15.89 10.70 340 686968 42335 63769089
Stasis dermatitis 15.88 10.70 36 687272 1075 63810349
Carbon dioxide increased 15.86 10.70 52 687256 1937 63809487
Alveolar osteitis 15.86 10.70 21 687287 401 63811023
Pulmonary veno-occlusive disease 15.86 10.70 42 687266 1386 63810038
Cyst 15.83 10.70 70 687238 11957 63799467
Fine motor skill dysfunction 15.82 10.70 16 687292 4683 63806741
Interstitial lung disease 15.82 10.70 1228 686080 96504 63714920
Right-to-left cardiac shunt 15.81 10.70 14 687294 165 63811259
Pancreatitis 15.78 10.70 499 686809 59108 63752316
Bipolar disorder 15.76 10.70 30 687278 6731 63804693
Acute myeloid leukaemia recurrent 15.76 10.70 5 687303 2779 63808645
Marasmus 15.74 10.70 31 687277 837 63810587
Presbyacusis 15.74 10.70 4 687304 2571 63808853
Peripheral sensory neuropathy 15.73 10.70 65 687243 11313 63800111
Rash erythematous 15.72 10.70 396 686912 48237 63763187
Inability to afford medication 15.67 10.70 50 687258 1836 63809588
Skin toxicity 15.65 10.70 29 687279 6573 63804851
Post procedural haematoma 15.65 10.70 57 687251 2241 63809183
Epilepsy 15.63 10.70 257 687051 33274 63778150
Meningitis aseptic 15.61 10.70 23 687285 5707 63805717
Oxygen consumption decreased 15.58 10.70 20 687288 370 63811054
Mental status changes 15.52 10.70 799 686509 60363 63751061
Liver injury 15.45 10.70 225 687083 29707 63781717
Cardiac operation 15.45 10.70 87 687221 4127 63807297
Bone density abnormal 15.42 10.70 5 687303 2740 63808684
Acidosis 15.40 10.70 271 687037 17524 63793900
Adenovirus infection 15.38 10.70 34 687274 7221 63804203
Cardioactive drug level above therapeutic 15.35 10.70 16 687292 234 63811190
Skin turgor decreased 15.35 10.70 26 687282 623 63810801
Ulcer haemorrhage 15.33 10.70 91 687217 4401 63807023
Gastritis haemorrhagic 15.31 10.70 56 687252 2206 63809218
Vaginal haemorrhage 15.30 10.70 132 687176 19212 63792212
Bone disorder 15.29 10.70 110 687198 16649 63794775
Hypoproteinaemia 15.28 10.70 74 687234 3308 63808116
Disseminated tuberculosis 15.27 10.70 10 687298 3635 63807789
Faecal calprotectin increased 15.23 10.70 10 687298 3630 63807794
Osteopenia 15.16 10.70 100 687208 15440 63795984
Drug abuser 15.16 10.70 24 687284 5784 63805640
Endophthalmitis 15.14 10.70 21 687287 5344 63806080
Thirst 15.12 10.70 223 687085 13914 63797510
Uraemic encephalopathy 15.11 10.70 23 687285 502 63810922
Visual field defect 15.05 10.70 41 687267 8105 63803319
Blood creatine abnormal 14.97 10.70 12 687296 122 63811302
Candida infection 14.91 10.70 240 687068 31179 63780245
Dyskinesia 14.90 10.70 313 686995 39075 63772349
Tetany 14.90 10.70 54 687254 2118 63809306
Gastrointestinal inflammation 14.88 10.70 27 687281 6168 63805256
End stage renal disease 14.87 10.70 174 687134 10301 63801123
Electrocardiogram repolarisation abnormality 14.83 10.70 49 687259 1833 63809591
Dizziness 14.81 10.70 4956 682352 425207 63386217
Social avoidant behaviour 14.80 10.70 16 687292 4541 63806883
Drug level increased 14.79 10.70 473 686835 33723 63777701
Hyperglycaemia 14.77 10.70 793 686515 60175 63751249
Coordination abnormal 14.75 10.70 96 687212 14868 63796556
Immune system disorder 14.74 10.70 49 687259 9092 63802332
Cystitis haemorrhagic 14.73 10.70 40 687268 7916 63803508
Visual acuity reduced 14.72 10.70 202 687106 26939 63784485
Euphoric mood 14.72 10.70 30 687278 6561 63804863
Impulsive behaviour 14.70 10.70 5 687303 2658 63808766
Cardiac death 14.69 10.70 39 687269 1289 63810135
Embolic stroke 14.68 10.70 122 687186 6589 63804835
Injection site inflammation 14.67 10.70 8 687300 3213 63808211
Skin lesion 14.67 10.70 287 687021 36195 63775229
Galactorrhoea 14.66 10.70 8 687300 3211 63808213
Hyperammonaemic encephalopathy 14.62 10.70 13 687295 4045 63807379
Volume blood decreased 14.61 10.70 17 687291 283 63811141
Portal hypertensive gastropathy 14.60 10.70 36 687272 1136 63810288
Metastases to lymph nodes 14.56 10.70 46 687262 8671 63802753
Catheter site erythema 14.53 10.70 95 687213 4754 63806670
Gastrointestinal arteriovenous malformation 14.52 10.70 31 687277 888 63810536
Toxic anterior segment syndrome 14.51 10.70 4 687304 2435 63808989
Lupus pneumonitis 14.50 10.70 10 687298 79 63811345
Sensory disturbance 14.45 10.70 82 687226 13126 63798298
Menstrual disorder 14.42 10.70 9 687299 3356 63808068
Diverticulum intestinal haemorrhagic 14.39 10.70 71 687237 3198 63808226
Gastric varices haemorrhage 14.35 10.70 18 687290 325 63811099
Cerebral infarction 14.34 10.70 554 686754 40490 63770934
Tic 14.31 10.70 5 687303 2614 63808810
Blood glucose decreased 14.31 10.70 335 686973 22788 63788636
Narrow anterior chamber angle 14.30 10.70 13 687295 159 63811265
Hepatic hydrothorax 14.28 10.70 9 687299 60 63811364
Myxoedema coma 14.27 10.70 26 687282 661 63810763
Sputum culture positive 14.24 10.70 67 687241 2959 63808465
Product preparation error 14.23 10.70 13 687295 3992 63807432
Device pacing issue 14.21 10.70 10 687298 82 63811342
Haemarthrosis 14.20 10.70 100 687208 5129 63806295
Haemorrhoidal haemorrhage 14.17 10.70 107 687201 5612 63805812
Eye pruritus 14.17 10.70 78 687230 12581 63798843
Tooth fracture 14.17 10.70 56 687252 9871 63801553
Hypoperfusion 14.16 10.70 56 687252 2290 63809134
Ejection fraction abnormal 14.14 10.70 40 687268 1373 63810051
Papilloedema 14.13 10.70 23 687285 5482 63805942
Nocardiosis 14.12 10.70 18 687290 4749 63806675
Tenderness 14.10 10.70 137 687171 19465 63791959
Cardiac hypertrophy 14.10 10.70 41 687267 1430 63809994
Partial seizures 14.09 10.70 36 687272 7271 63804153
Drug-induced liver injury 14.07 10.70 393 686915 47250 63764174
Normocytic anaemia 14.06 10.70 71 687237 3228 63808196
Implantable defibrillator insertion 14.04 10.70 28 687280 763 63810661
Infected skin ulcer 14.04 10.70 66 687242 2914 63808510
Diabetic metabolic decompensation 14.03 10.70 62 687246 2666 63808758
Attention deficit hyperactivity disorder 13.96 10.70 6 687302 2764 63808660
Facial paresis 13.95 10.70 19 687289 4873 63806551
Eye disorder 13.95 10.70 131 687177 18738 63792686
Finger deformity 13.95 10.70 21 687287 5165 63806259
Pulmonary alveolar haemorrhage 13.93 10.70 162 687146 9576 63801848
Disseminated intravascular coagulation 13.87 10.70 447 686861 31901 63779523
Portopulmonary hypertension 13.86 10.70 12 687296 137 63811287
Latent tuberculosis 13.85 10.70 6 687302 2751 63808673
Dizziness postural 13.85 10.70 162 687146 9590 63801834
Anosmia 13.81 10.70 16 687292 4401 63807023
Paroxysmal arrhythmia 13.77 10.70 8 687300 45 63811379
Nasal mucosal erosion 13.70 10.70 9 687299 65 63811359
Acute graft versus host disease in intestine 13.69 10.70 11 687297 3598 63807826
Cytomegalovirus viraemia 13.67 10.70 64 687244 10764 63800660
Rectal prolapse 13.66 10.70 45 687263 1681 63809743
Staphylococcal sepsis 13.61 10.70 203 687105 12696 63798728
Osteonecrosis 13.61 10.70 215 687093 28014 63783410
Psychomotor hyperactivity 13.60 10.70 94 687214 14357 63797067
Coma hepatic 13.59 10.70 32 687276 980 63810444
Hepatorenal failure 13.56 10.70 35 687273 1137 63810287
Rectal ulcer haemorrhage 13.54 10.70 15 687293 236 63811188
Lymphocyte count decreased 13.53 10.70 330 686978 40369 63771055
Sinus arrest 13.52 10.70 67 687241 3023 63808401
Internal haemorrhage 13.51 10.70 133 687175 7534 63803890
Diabetic hyperosmolar coma 13.51 10.70 26 687282 690 63810734
Polyneuropathy 13.50 10.70 141 687167 19753 63791671
Linear IgA disease 13.49 10.70 62 687246 2712 63808712
Premature rupture of membranes 13.48 10.70 12 687296 3732 63807692
Bronchial secretion retention 13.43 10.70 58 687250 2469 63808955
Hypoprothrombinaemia 13.43 10.70 26 687282 693 63810731
Type I hypersensitivity 13.42 10.70 11 687297 3563 63807861
Myalgia 13.42 10.70 1482 685826 157135 63654289
Haemothorax 13.39 10.70 93 687215 4749 63806675
Injection site nodule 13.35 10.70 9 687299 3221 63808203
Gait disturbance 13.35 10.70 1618 685690 170537 63640887
Metastases to central nervous system 13.33 10.70 90 687218 13822 63797602
Ventricular hypokinesia 13.32 10.70 134 687174 7635 63803789
Drug specific antibody 13.30 10.70 3 687305 2092 63809332
Acute myeloid leukaemia 13.30 10.70 209 687099 27254 63784170
Arteriovenous malformation 13.29 10.70 42 687266 1534 63809890
Localised oedema 13.29 10.70 126 687182 7065 63804359
Heart valve incompetence 13.26 10.70 62 687246 2731 63808693
Encephalitis 13.24 10.70 79 687229 12492 63798932
Abnormal dreams 13.19 10.70 61 687247 10295 63801129
Right ventricular systolic pressure decreased 13.17 10.70 9 687299 70 63811354
Pulmonary artery dilatation 13.16 10.70 18 687290 355 63811069
Tooth disorder 13.15 10.70 164 687144 22238 63789186
Nephropathy 13.13 10.70 142 687166 8244 63803180
Polyarthritis 13.12 10.70 56 687252 9659 63801765
Conjunctivitis 13.11 10.70 146 687162 20208 63791216
Right atrial hypertrophy 13.11 10.70 22 687286 523 63810901
Large intestinal polypectomy 13.11 10.70 15 687293 245 63811179
Postpericardiotomy syndrome 13.10 10.70 8 687300 50 63811374
Kounis syndrome 13.09 10.70 8 687300 3017 63808407
Ear pruritus 13.03 10.70 6 687302 2654 63808770
Sacroiliitis 12.98 10.70 8 687300 3004 63808420
Transplant dysfunction 12.98 10.70 33 687275 6675 63804749
Femoral artery aneurysm 12.97 10.70 13 687295 181 63811243
Dysgeusia 12.91 10.70 392 686916 46655 63764769
Pulmonary arterial wedge pressure increased 12.89 10.70 20 687288 444 63810980
Peripheral vascular disorder 12.82 10.70 126 687182 7135 63804289
Cardiac ventricular disorder 12.79 10.70 17 687291 326 63811098
Cardiac failure high output 12.78 10.70 15 687293 252 63811172
Lymphocyte stimulation test positive 12.76 10.70 33 687275 1073 63810351
Hyperbilirubinaemia 12.75 10.70 306 687002 20899 63790525
Personality disorder 12.74 10.70 19 687289 4692 63806732
Pallor 12.74 10.70 520 686788 38261 63773163
CD4 lymphocytes decreased 12.72 10.70 5 687303 2430 63808994
Blood zinc decreased 12.71 10.70 5 687303 9 63811415
Infection reactivation 12.71 10.70 3 687305 2027 63809397
Delayed graft function 12.70 10.70 65 687243 2971 63808453
Haemorrhagic stroke 12.70 10.70 162 687146 9789 63801635
Vertebrobasilar insufficiency 12.64 10.70 13 687295 187 63811237
Acquired haemophilia 12.61 10.70 42 687266 1578 63809846
Tachycardia induced cardiomyopathy 12.54 10.70 11 687297 128 63811296
Injury 12.53 10.70 723 686585 55269 63756155
PO2 abnormal 12.51 10.70 6 687302 21 63811403
Catheter removal 12.50 10.70 22 687286 544 63810880
Troponin T increased 12.50 10.70 54 687254 2299 63809125
Zinc deficiency 12.50 10.70 8 687300 55 63811369
Nocturnal dyspnoea 12.47 10.70 37 687271 1305 63810119
Thermohypoaesthesia 12.45 10.70 10 687298 102 63811322
Panic attack 12.45 10.70 153 687155 20800 63790624
Hostility 12.43 10.70 4 687304 2203 63809221
Blood pressure systolic abnormal 12.41 10.70 59 687249 9883 63801541
Platelet transfusion 12.40 10.70 45 687263 1766 63809658
Atrioventricular block second degree 12.39 10.70 114 687194 6340 63805084
Abnormal loss of weight 12.38 10.70 127 687181 7273 63804151
Diabetes with hyperosmolarity 12.38 10.70 5 687303 10 63811414
Intestinal pseudo-obstruction 12.29 10.70 48 687260 1952 63809472
Haemorrhagic arteriovenous malformation 12.28 10.70 22 687286 552 63810872
Change of bowel habit 12.23 10.70 55 687253 2383 63809041
Movement disorder 12.20 10.70 163 687145 21837 63789587
Left ventricle outflow tract obstruction 12.18 10.70 16 687292 303 63811121
Brain abscess 12.17 10.70 16 687292 4165 63807259
Pain in jaw 12.16 10.70 541 686767 40214 63771210
Drug monitoring procedure not performed 12.15 10.70 27 687281 795 63810629
Sickle cell anaemia with crisis 12.14 10.70 24 687284 5308 63806116
Aortic valve disease 12.13 10.70 41 687267 1552 63809872
Urine osmolarity decreased 12.11 10.70 9 687299 81 63811343
Fabry's disease 12.11 10.70 6 687302 23 63811401
Nail disorder 12.09 10.70 49 687259 8575 63802849
Gastrointestinal toxicity 12.07 10.70 24 687284 5298 63806126
Product prescribing error 12.07 10.70 475 686833 34794 63776630
Ectopic gastric mucosa 12.06 10.70 5 687303 11 63811413
Supraventricular tachycardia 12.03 10.70 275 687033 18632 63792792
Splenic injury 12.03 10.70 14 687294 233 63811191
Base excess increased 12.02 10.70 9 687299 82 63811342
Suicidal behaviour 11.99 10.70 8 687300 2879 63808545
Respiratory acidosis 11.97 10.70 159 687149 9696 63801728
Renal atrophy 11.95 10.70 42 687266 1622 63809802
Gastrointestinal pain 11.94 10.70 41 687267 7533 63803891
Injection site extravasation 11.93 10.70 45 687263 8041 63803383
Ventricular dyskinesia 11.92 10.70 18 687290 390 63811034
Hypermagnesaemia 11.92 10.70 32 687276 1065 63810359
Venous pressure increased 11.91 10.70 6 687302 24 63811400
Cardiac resynchronisation therapy 11.91 10.70 6 687302 24 63811400
Neoplasm malignant 11.91 10.70 188 687120 24500 63786924
Iridocyclitis 11.91 10.70 9 687299 3036 63808388
Tension 11.90 10.70 14 687294 3826 63807598
Myocarditis 11.89 10.70 120 687188 16923 63794501
Major depression 11.86 10.70 43 687265 7773 63803651
Red blood cell count decreased 11.85 10.70 630 686678 47756 63763668
Coma uraemic 11.83 10.70 7 687301 41 63811383
Base excess decreased 11.82 10.70 17 687291 352 63811072
Self-injurious ideation 11.81 10.70 10 687298 3187 63808237
Dependence on oxygen therapy 11.79 10.70 18 687290 394 63811030
Hyperamylasaemia 11.78 10.70 28 687280 863 63810561
Cystatin C increased 11.77 10.70 5 687303 12 63811412
Urine potassium increased 11.77 10.70 5 687303 12 63811412
Speech disorder 11.77 10.70 410 686898 48031 63763393
Cutaneous vasculitis 11.76 10.70 113 687195 6360 63805064
Melanocytic naevus 11.75 10.70 16 687292 4104 63807320
Aortic aneurysm 11.74 10.70 128 687180 7446 63803978
Drug tolerance 11.72 10.70 30 687278 6055 63805369
Blood aldosterone increased 11.71 10.70 13 687295 205 63811219
Sight disability 11.70 10.70 10 687298 112 63811312
Mucosal dryness 11.70 10.70 63 687245 2938 63808486
Periorbital haematoma 11.67 10.70 28 687280 868 63810556
Humerus fracture 11.65 10.70 132 687176 7753 63803671
Enteritis 11.64 10.70 78 687230 11999 63799425
Sodium retention 11.59 10.70 9 687299 87 63811337
Loss of employment 11.58 10.70 3 687305 1904 63809520
Penile haemorrhage 11.58 10.70 20 687288 487 63810937
Accidental exposure to product by child 11.57 10.70 6 687302 2479 63808945
Petechiae 11.57 10.70 270 687038 18356 63793068
Fistula 11.56 10.70 59 687249 9702 63801722
Pulmonary interstitial emphysema syndrome 11.55 10.70 19 687289 444 63810980
Strangury 11.54 10.70 12 687296 175 63811249
Restlessness 11.54 10.70 329 686979 39456 63771968
Lymphadenitis 11.52 10.70 14 687294 3771 63807653
Deafness bilateral 11.50 10.70 45 687263 1831 63809593
Pituitary tumour benign 11.50 10.70 5 687303 2288 63809136
Hypertension 11.50 10.70 2515 684793 256746 63554678
Tracheostomy 11.50 10.70 32 687276 1088 63810336
Inguinal hernia 11.44 10.70 100 687208 5481 63805943
Prothrombin time abnormal 11.40 10.70 27 687281 830 63810594
Normal newborn 11.36 10.70 27 687281 5590 63805834
Catheter site pain 11.35 10.70 84 687224 4378 63807046
Skin papilloma 11.35 10.70 24 687284 5179 63806245
Urine chloride decreased 11.35 10.70 9 687299 90 63811334
SARS-CoV-2 test positive 11.35 10.70 32 687276 6254 63805170
Adjustment disorder with depressed mood 11.34 10.70 6 687302 2451 63808973
Urethral haemorrhage 11.34 10.70 17 687291 366 63811058
Vaginal infection 11.32 10.70 22 687286 4898 63806526
Cardiac tamponade 11.32 10.70 135 687173 8029 63803395
Bleeding time prolonged 11.31 10.70 33 687275 1153 63810271
Focal dyscognitive seizures 11.31 10.70 11 687297 3279 63808145
Renal hypertrophy 11.31 10.70 7 687301 45 63811379
Resting tremor 11.31 10.70 37 687271 1377 63810047
Diagnostic procedure 11.27 10.70 11 687297 148 63811276
Cirrhosis alcoholic 11.25 10.70 29 687279 941 63810483
Bilirubin conjugated increased 11.24 10.70 91 687217 4877 63806547
Hypogammaglobulinaemia 11.23 10.70 64 687244 10235 63801189
Incision site pain 11.23 10.70 57 687251 2597 63808827
Somatic symptom disorder 11.23 10.70 3 687305 1865 63809559
Drug screen positive 11.23 10.70 28 687280 5701 63805723
Cystic fibrosis 11.21 10.70 12 687296 3422 63808002
Blood lactate dehydrogenase increased 11.21 10.70 445 686863 32633 63778791
Arthrodesis 11.20 10.70 4 687304 2063 63809361
Aspartate aminotransferase increased 11.19 10.70 1449 685859 118339 63693085
Brain compression 11.18 10.70 20 687288 501 63810923
Shoshin beriberi 11.13 10.70 8 687300 68 63811356
Hepatitis E 11.13 10.70 6 687302 2425 63808999
Bradyphrenia 11.11 10.70 151 687157 9255 63802169
Gastroenteritis norovirus 11.11 10.70 8 687300 2767 63808657
Oral disorder 11.10 10.70 53 687255 8868 63802556
Feeling drunk 11.08 10.70 17 687291 4150 63807274
Waist circumference increased 11.08 10.70 36 687272 1335 63810089
Hypertensive cardiomyopathy 11.08 10.70 15 687293 293 63811131
Epicondylitis 11.08 10.70 3 687305 1848 63809576
Immunosuppression 11.07 10.70 68 687240 10678 63800746
Endometriosis male 10.99 10.70 5 687303 15 63811409
Psychogenic seizure 10.99 10.70 3 687305 1838 63809586
Right ventricular systolic pressure increased 10.97 10.70 27 687281 851 63810573
Blood glucose increased 10.97 10.70 1200 686108 96873 63714551
Exostosis 10.96 10.70 74 687234 11364 63800060
Cerebral artery embolism 10.96 10.70 40 687268 1574 63809850
Cardiothoracic ratio increased 10.95 10.70 7 687301 48 63811376
Anaemia of chronic disease 10.93 10.70 50 687258 2182 63809242
Peripheral embolism 10.93 10.70 43 687265 1754 63809670
Embedded device 10.93 10.70 8 687300 2744 63808680
Adrenal insufficiency 10.93 10.70 171 687137 22316 63789108
Urine output increased 10.90 10.70 44 687264 1817 63809607
Mouth breathing 10.83 10.70 10 687298 125 63811299
Genital haemorrhage 10.81 10.70 27 687281 5495 63805929
Squamous cell carcinoma 10.81 10.70 95 687213 13774 63797650
Angioplasty 10.81 10.70 41 687267 1644 63809780
International normalised ratio 10.81 10.70 9 687299 97 63811327
Blood pressure inadequately controlled 10.79 10.70 96 687212 5288 63806136
Mobility decreased 10.78 10.70 778 686530 85062 63726362
Wrong strength 10.76 10.70 11 687297 157 63811267
Acid base balance abnormal 10.74 10.70 15 687293 302 63811122
Hyperphosphataemia 10.74 10.70 76 687232 3905 63807519
ECG signs of myocardial ischaemia 10.72 10.70 16 687292 343 63811081
Bifascicular block 10.72 10.70 16 687292 343 63811081
Diverticulum 10.72 10.70 199 687109 12999 63798425
Differential white blood cell count abnormal 10.71 10.70 3 687305 1807 63809617
Transaminases increased 10.71 10.70 378 686930 44216 63767208

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03CA01 CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Sulfonamides, plain
ATC C03CB01 CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Sulfonamides and potassium in combination
ATC C03EB01 CARDIOVASCULAR SYSTEM
DIURETICS
DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
High-ceiling diuretics and potassium-sparing agents
FDA PE N0000175366 Increased Diuresis at Loop of Henle
FDA EPC N0000175590 Loop Diuretic
MeSH PA D004232 Diuretics
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D045283 Natriuretic Agents
MeSH PA D049994 Sodium Potassium Chloride Symporter Inhibitors
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:77608 loop diuretics
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Acute pulmonary edema indication 40541001
Decompensated cardiac failure indication 195111005
Edema indication 267038008
Pulmonary Edema due to Chronic Heart Failure indication
Edema due to Hepatic Cirrhosis indication
Peripheral Edema due to Chronic Heart Failure indication
Hypercalcemia off-label use 66931009 DOID:12678
Prevention of Oliguria off-label use
Metabolic alkalosis contraindication 1388004
Anuria contraindication 2472002 DOID:2983
Hypocalcemia contraindication 5291005
Hypochloremia contraindication 10399008
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Diabetes mellitus contraindication 73211009 DOID:9351
Pancreatitis contraindication 75694006 DOID:4989
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Hearing disorder contraindication 128540005
Hypomagnesemia contraindication 190855004
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Azotemia contraindication 445009001




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Cats Edema (pulmonary congestion, ascites) associated with cardiac insufficiency Indication
Cats Acute noninflammatory tissue edema Indication
Cattle Physiological parturient edema of the mammary gland and associated structures Indication
Dogs Edema (pulmonary congestion, ascites) associated with cardiac insufficiency Indication
Dogs Acute noninflammatory tissue edema Indication
Horses Edema (pulmonary congestion, ascites) associated with cardiac insufficiency Indication
Horses Acute noninflammatory tissue edema Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Salix Injection 5% Intervet Inc. 1
Salix Tablets Intervet Inc. 1
Lasix Packets Intervet Inc. 1
Lasix Syrup 1% Intervet Inc. 1
Furos-A-Vet Bimeda Animal Health Limited 1
Disal Injection Boehringer lngelheim Animal Health USA Inc. 1
Disal Boehringer lngelheim Animal Health USA Inc. 1
Disal Boehringer lngelheim Animal Health USA Inc. 1
Furosemide Injection 5% Elanco US Inc. 1
Furosemide Syrup 1% First Priority Inc. 1
Furosemide Syrup 1% Cronus Pharma Specialities India Private Limited 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.69 acidic
pKa2 10.59 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Solute carrier family 12 member 1 Transporter INHIBITOR IC50 6.20 WOMBAT-PK CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-1 Transporter WOMBAT-PK
Carbonic anhydrase 2 Enzyme Ki 7.19 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 7.21 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 6.25 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 6.38 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 6.58 CHEMBL
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 6.30 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 6.49 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 6.29 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 6.61 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 7.28 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme IC50 5.42 CHEMBL
Solute carrier family 12 member 2 Transporter INHIBITOR IC50 5.13 IUPHAR
G-protein coupled receptor 35 GPCR Ki 5.49 CHEMBL
CDGSH iron-sulfur domain-containing protein 1 Unclassified Ki 5.64 CHEMBL
Carbonic anhydrase 13 Enzyme Ki 6.26 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme IC50 5.42 CHEMBL
Holo-[acyl-carrieir-protein] synthase Enzyme IC50 4.90 CHEMBL

External reference:

IDSource
4017830 VUID
N0000146188 NUI
D00331 KEGG_DRUG
4017830 VANDF
C0016860 UMLSCUI
CHEBI:47426 CHEBI
FUN PDB_CHEM_ID
CHEMBL35 ChEMBL_ID
CHEMBL1788133 ChEMBL_ID
DB00695 DRUGBANK_ID
D005665 MESH_DESCRIPTOR_UI
3440 PUBCHEM_CID
4839 IUPHAR_LIGAND_ID
1584 INN_ID
7LXU5N7ZO5 UNII
4603 RXNORM
3962 MMSL
4769 MMSL
d00070 MMSL
002307 NDDF
387475002 SNOMEDCT_US
81609008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-3294 SOLUTION 10 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-3298 SOLUTION 40 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4297 TABLET 20 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4299 TABLET 40 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4301 TABLET 80 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8297 TABLET 20 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8299 TABLET 40 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8301 TABLET 80 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0208 TABLET 20 mg ORAL NDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0216 TABLET 40 mg ORAL NDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0232 TABLET 80 mg ORAL ANDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0404-9861 INJECTION, SOLUTION 10 mg INTRAMUSCULAR ANDA 12 sections
FUROSEMIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9862 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0404-9863 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 13 sections
FUROSEMIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9864 INJECTION, SOLUTION 20 mg INTRAMUSCULAR ANDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0409-1639 INJECTION, SOLUTION 10 mg INTRAMUSCULAR ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0409-6102 INJECTION, SOLUTION 10 mg INTRAMUSCULAR NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0409-6102 INJECTION, SOLUTION 10 mg INTRAMUSCULAR NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0409-9631 INJECTION, SOLUTION 10 mg INTRAMUSCULAR ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7937 TABLET 20 mg ORAL NDA 11 sections
Fuosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7938 TABLET 40 mg ORAL NDA 11 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7957 TABLET 80 mg ORAL ANDA 11 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-8368 TABLET 20 mg ORAL ANDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-8369 TABLET 40 mg ORAL ANDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-8370 TABLET 80 mg ORAL ANDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0904-7177 TABLET 20 mg ORAL ANDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0904-7178 TABLET 40 mg ORAL ANDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 10544-131 TABLET 20 mg ORAL ANDA 13 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 10544-584 TABLET 40 mg ORAL ANDA 13 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 12634-416 TABLET 20 mg ORAL ANDA 18 sections