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Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
diuretics, furosemide derivatives	1258	54-31-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: frusemide furosemide furosemid	A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY. Molecular weight: 330.74 Formula: C12H11ClN2O5S CLOGP: 1.90 LIPINSKI: 0 HAC: 7 HDO: 3 TPSA: 122.63 ALOGS: -3.45 ROTB: 5 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

frusemide
furosemide
furosemid

A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.

Molecular weight: 330.74
Formula: C12H11ClN2O5S
CLOGP: 1.90
LIPINSKI: 0
HAC: 7
HDO: 3
TPSA: 122.63
ALOGS: -3.45
ROTB: 5

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
40	mg	O
40	mg	P
40	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	4	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	66 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	25.92 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	71 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.12 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	1.60 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.01 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	2.50 hours	Lombardo F, Berellini G, Obach RS
S (Water solubility)	0.07 mg/mL	Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
azlogd74	LogD at pH 7.4	-0.889		High	0.86
caco2-efflux	Caco-2 efflux ratio (BA/AB)	12.972		High	0.86
caco2-intrinsic-papp	Caco-2 intrinsic apparent permeability	1.517	10^-6 cm/s	High	0.86
dh-clint	Dog hepatocyte intrinsic clearance	3.873	uL/min/10^6 cells	High	0.86
dppb	Dog plasma protein binding (% unbound)	7.550	%	High	0.86
fcs-ppb	Fetal calf serum protein binding (% unbound)	13.250	%	High	0.86
herg	hERG pIC50	4.098	pIC50	High	0.86
hh-clint	Human hepatocyte intrinsic clearance	1.718	uL/min/10^6 cells	High	0.86
hlm-clint	Human liver microsomal intrinsic clearance	2.965	uL/min/mg protein	High	0.86
hppb	Human plasma protein binding (% unbound)	2.850	%	High	0.86
kinase-safety-class	ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDPK1,PIK3CB,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70	53
kinase-selectivity-class	ACVR2B,AXL,BRAF,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,MAP2K6,MAPK7,PIK3CB,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TTK	20
mdck-mdr1-bcrp-efflux	MDCK-MDR1-BCRP efflux ratio	2.630		High	1
mdck-mdr1-efflux	MDCK-MDR1 efflux ratio	1.514		High	0.86
mh-clint	Mouse hepatocyte intrinsic clearance	10.351		High	0.86
mppb	Mouse plasma protein binding (% unbound)	10.360		High	0.86
nih-mdck-mdr1-efflux	NIH MDCK-MDR1 efflux ratio	0.681		High	0.86
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pld-class	Phospholipidosis risk class (1 = positive, 0 = negative)	0		High	1
pppb	Pig plasma protein binding (% unbound)	6.400	%	High	0.86
rat-kpuu-brain	Rat brain Kpuu	0.015	%	High	1
rh-clint	Rat hepatocyte intrinsic clearance	11.803	uL/min/10^6 cells	High	0.86
rh-fuinc	Rat hepatocyte fraction unbound in incubation	87.040	%	High	0.86
rppb	Rat plasma protein binding (% unbound)	2.690	%	High	0.86
solubility-dd	Solubility at pH 7.4 in DMSO	974.990	uM	High	0.86

Approvals:

Date	Agency	Company	Orphan
July 1, 1966	FDA	SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	5111.53	10.26	8072	568121	312315	89739939
Cardiac failure congestive	3238.81	10.26	3551	572642	95143	89957111
Cardiac failure	2329.36	10.26	3165	573028	106331	89945923
Hyperkalaemia	2122.59	10.26	2333	573860	62631	89989623
Pemphigus	1964.31	10.26	21	576172	326843	89725411
Hyponatraemia	1785.13	10.26	3113	573080	130425	89921829
Hand deformity	1758.49	10.26	24	576169	296338	89755916
Glossodynia	1742.93	10.26	70	576123	321709	89730545
Hypotension	1659.04	10.26	5188	571005	320209	89732045
Systemic lupus erythematosus	1533.42	10.26	235	575958	361661	89690593
Renal failure	1402.06	10.26	2776	573417	128231	89924023
Drug interaction	1397.65	10.26	4396	571797	272057	89780197
Drug ineffective	1397.33	10.26	4358	571835	1379940	88672314
Pericarditis	1332.64	10.26	101	576092	270050	89782204
Arthropathy	1326.24	10.26	346	575847	365896	89686358
Duodenal ulcer perforation	1299.27	10.26	21	576172	221267	89830987
Synovitis	1214.07	10.26	301	575892	329451	89722803
Alopecia	1213.20	10.26	832	575361	494239	89558015
Helicobacter infection	1209.26	10.26	55	576138	226795	89825459
Hypokalaemia	1196.12	10.26	2602	573591	128514	89923740
International normalised ratio increased	1168.93	10.26	1473	574720	45843	90006411
Folliculitis	1161.36	10.26	29	576164	204324	89847930
Atrial fibrillation	1146.10	10.26	2587	573606	131024	89921230
Wound	1074.44	10.26	298	575895	302682	89749572
Anaemia	1064.79	10.26	4753	571440	348049	89704205
Rheumatoid factor positive	1055.11	10.26	6	576187	171644	89880610
Muscle injury	1015.65	10.26	22	576171	176632	89875622
Infusion related reaction	994.88	10.26	720	575473	416060	89636194
Bradycardia	985.24	10.26	1849	574344	81998	89970256
Dyspnoea	985.07	10.26	9214	566979	871741	89180513
Fall	981.45	10.26	5814	570379	475996	89576258
Therapeutic product effect decreased	974.87	10.26	278	575915	277293	89774961
Maternal exposure during pregnancy	970.44	10.26	541	575652	359522	89692732
Contraindicated product administered	959.55	10.26	417	575776	319722	89732532
Drug intolerance	949.26	10.26	869	575324	446722	89605532
Rheumatic fever	942.96	10.26	5	576188	153116	89899138
Oedema peripheral	933.30	10.26	3674	572519	254241	89798013
Irritable bowel syndrome	931.97	10.26	112	576081	207336	89844918
Discomfort	912.62	10.26	303	575890	274032	89778222
Abdominal discomfort	887.69	10.26	1037	575156	476291	89575963
Psoriatic arthropathy	884.91	10.26	186	576007	228149	89824105
Treatment failure	840.21	10.26	442	575751	303486	89748768
Dehydration	829.33	10.26	2921	573272	191526	89860728
Renal impairment	818.12	10.26	1963	574230	103458	89948796
Pulmonary hypertension	809.29	10.26	1166	575027	41357	90010897
Impaired healing	755.85	10.26	272	575921	233927	89818327
Sleep disorder due to general medical condition, insomnia type	751.92	10.26	13	576180	128681	89923573
Gastrointestinal haemorrhage	712.64	10.26	1692	574501	88556	89963698
Pulmonary arterial hypertension	697.76	10.26	847	575346	25340	90026914
Musculoskeletal stiffness	697.14	10.26	520	575673	296012	89756242
Off label use	693.38	10.26	4145	572048	1098107	88954147
Swollen joint count increased	688.06	10.26	3	576190	111203	89941051
Ill-defined disorder	687.40	10.26	165	576028	184726	89867528
Hepatic enzyme increased	684.00	10.26	771	575422	359965	89692289
Melaena	681.03	10.26	967	575226	33830	90018424
Hypersensitivity	674.15	10.26	1160	575033	453517	89598737
Type 2 diabetes mellitus	673.12	10.26	226	575967	203018	89849236
Joint swelling	657.92	10.26	1385	574808	501915	89550339
Blood creatinine increased	657.55	10.26	1764	574429	99622	89952632
Drug hypersensitivity	650.40	10.26	1224	574969	462385	89589869
Myocardial infarction	641.73	10.26	1798	574395	104174	89948080
Syncope	641.35	10.26	2079	574114	130584	89921670
Rheumatoid arthritis	635.55	10.26	824	575369	361790	89690464
Lactic acidosis	624.25	10.26	1138	575055	49325	90002929
Orthostatic hypotension	609.59	10.26	1014	575179	40813	90011441
Fluid retention	605.16	10.26	1566	574627	86525	89965729
Swelling	595.98	10.26	1097	575096	417961	89634293
Pulmonary oedema	586.33	10.26	1250	574943	60830	89991424
Facet joint syndrome	574.50	10.26	10	576183	98379	89953875
Liver injury	567.68	10.26	188	576005	170379	89881875
Hypoglycaemia	563.83	10.26	1321	574872	68527	89983727
Lip dry	563.46	10.26	17	576176	100938	89951316
Right ventricular failure	557.55	10.26	649	575544	18556	90033698
Stomatitis	555.31	10.26	556	575637	274142	89778112
Arthralgia	548.27	10.26	2818	573375	775704	89276550
C-reactive protein abnormal	543.10	10.26	81	576112	127348	89924906
Gastrointestinal disorder	541.60	10.26	500	575693	256187	89796067
Sleep disorder	525.24	10.26	303	575890	197727	89854527
Fibromyalgia	522.79	10.26	333	575860	205936	89846318
Death	510.58	10.26	4781	571412	451770	89600484
Joint range of motion decreased	498.37	10.26	124	576069	135519	89916735
Intentional product use issue	485.98	10.26	399	575794	216493	89835761
Blood urea increased	482.15	10.26	766	575427	29647	90022607
Sinusitis	481.53	10.26	905	575288	342183	89710071
Pleural effusion	463.05	10.26	1666	574527	110325	89941929
Urticaria	450.32	10.26	812	575381	311922	89740332
Blood cholesterol increased	449.72	10.26	396	575797	207616	89844638
Nasopharyngitis	445.53	10.26	1229	574964	405875	89646379
Lower respiratory tract infection	444.72	10.26	564	575629	250095	89802159
Rash	443.05	10.26	3104	573089	792996	89259258
Hypervolaemia	438.86	10.26	765	575428	31992	90020262
Blister	438.81	10.26	587	575606	254411	89797843
Grip strength decreased	435.95	10.26	42	576151	92534	89959720
Pain	428.53	10.26	4162	572031	992179	89060075
Torsade de pointes	414.15	10.26	497	575696	14685	90037569
Night sweats	404.42	10.26	156	576037	128610	89923644
Haemoglobin decreased	403.31	10.26	2066	574127	159890	89892364
Therapeutic product effect incomplete	395.68	10.26	389	575804	193507	89858747
Respiratory failure	392.73	10.26	1643	574550	116775	89935479
Product use issue	383.66	10.26	966	575227	328953	89723301
Ascites	374.50	10.26	893	575300	46847	90005407
Chronic kidney disease	363.03	10.26	910	575283	49281	90002973
Haematoma	354.62	10.26	774	575419	38274	90013980
Creatinine renal clearance decreased	343.23	10.26	507	575686	18392	90033862
Metabolic alkalosis	340.61	10.26	236	575957	3313	90048941
Hypercholesterolaemia	339.50	10.26	109	576084	100783	89951471
Inflammation	334.54	10.26	385	575808	178207	89874047
Hypoaesthesia	329.27	10.26	968	575225	313242	89739012
Product use in unapproved indication	328.18	10.26	1070	575123	335166	89717088
Rhabdomyolysis	327.33	10.26	887	575306	50369	90001885
Injury	326.69	10.26	467	575726	196882	89855372
Blepharospasm	326.33	10.26	5	576188	55440	89996814
Wound infection	325.78	10.26	134	576059	106268	89945986
Autoimmune disorder	319.66	10.26	52	576141	76692	89975562
Injection site reaction	308.91	10.26	100	576093	91980	89960274
Multiple organ dysfunction syndrome	306.94	10.26	1045	575148	67291	89984963
Wheezing	295.78	10.26	673	575520	237407	89814847
Electrocardiogram QT prolonged	292.73	10.26	1070	575123	71386	89980868
Sepsis	290.54	10.26	2049	574144	177765	89874489
Epistaxis	289.98	10.26	1191	575002	83934	89968320
Dyspnoea exertional	289.09	10.26	1064	575129	71224	89981030
Hip arthroplasty	287.09	10.26	66	576127	76142	89976112
Live birth	285.38	10.26	75	576118	79032	89973222
Chronic obstructive pulmonary disease	283.85	10.26	1073	575120	72756	89979498
Depressed level of consciousness	283.30	10.26	1062	575131	71722	89980532
Peripheral venous disease	276.51	10.26	94	576099	83827	89968427
Acute myocardial infarction	275.11	10.26	654	575539	34236	90018018
Red blood cell sedimentation rate increased	274.78	10.26	91	576102	82504	89969750
Hypoxia	274.04	10.26	1047	575146	71352	89980902
Cardiac failure chronic	273.09	10.26	251	575942	5395	90046859
Cardioactive drug level increased	263.41	10.26	173	576020	2211	90050043
Gait inability	263.31	10.26	326	575867	146130	89906124
Bursitis	262.95	10.26	269	575924	131385	89920869
Cardiac failure acute	255.06	10.26	346	575847	11583	90040671
Cardiac arrest	251.68	10.26	1325	574868	103610	89948644
Obesity	250.28	10.26	183	576010	105324	89946930
Road traffic accident	249.74	10.26	191	576002	107435	89944819
Osteoarthritis	249.04	10.26	546	575647	195184	89857070
Coronary artery disease	248.80	10.26	615	575578	33008	90019246
Migraine	247.31	10.26	525	575668	189867	89862387
Pneumonia	245.37	10.26	5541	570652	632518	89419736
X-ray abnormal	245.23	10.26	10	576183	45414	90006840
Bone erosion	242.02	10.26	27	576166	52994	89999260
Dry mouth	238.68	10.26	508	575685	183551	89868703
Sciatica	237.70	10.26	178	576015	101204	89951050
Cellulitis	236.26	10.26	1178	575015	90159	89962095
Nail disorder	235.15	10.26	45	576148	59022	89993232
Pregnancy	233.20	10.26	54	576139	61993	89990261
Urine output decreased	233.05	10.26	341	575852	12262	90039992
Hepatic encephalopathy	232.36	10.26	357	575836	13415	90038839
Acute respiratory failure	230.62	10.26	698	575495	42220	90010034
Sopor	230.05	10.26	494	575699	24150	90028104
Cardiac disorder	228.15	10.26	838	575355	56034	89996220
Hypomagnesaemia	226.35	10.26	615	575578	34973	90017281
Blood pressure decreased	225.88	10.26	1010	575183	73885	89978369
Infection	219.74	10.26	1374	574819	360720	89691534
Generalised oedema	219.70	10.26	417	575776	18636	90033618
Cerebrovascular accident	219.32	10.26	1441	574752	122092	89930162
Blood potassium decreased	218.85	10.26	735	575458	46992	90005262
Balance disorder	218.02	10.26	1204	574989	95876	89956378
Knee arthroplasty	217.98	10.26	129	576064	83053	89969201
Blood calcium decreased	216.95	10.26	546	575647	29636	90022618
Onychomadesis	216.20	10.26	21	576172	45977	90006277
Musculoskeletal pain	214.33	10.26	482	575711	170769	89881485
Paraesthesia	213.30	10.26	843	575350	249483	89802771
Pulmonary fibrosis	208.66	10.26	225	575968	107278	89944976
Cardiomegaly	208.17	10.26	406	575787	18519	90033735
Sedation complication	208.07	10.26	381	575812	16563	90035691
Ventricular tachycardia	206.66	10.26	474	575719	24234	90028020
Abortion spontaneous	205.24	10.26	46	576147	54010	89998244
Oxygen saturation decreased	205.12	10.26	1277	574916	106206	89946048
Cardiogenic shock	197.63	10.26	463	575730	24005	90028249
Lower limb fracture	197.07	10.26	151	576042	84862	89967392
Transfusion	197.03	10.26	379	575814	17109	90035145
Pericardial effusion	194.12	10.26	595	575598	36238	90016016
Device expulsion	193.93	10.26	18	576175	40868	90011386
Mitral valve incompetence	193.83	10.26	437	575756	22087	90030167
Breast cancer stage II	193.41	10.26	7	576186	35327	90016927
Adverse event	193.11	10.26	279	575914	117139	89935115
Lupus-like syndrome	192.79	10.26	38	576155	48808	90003446
Presyncope	192.73	10.26	540	575653	31265	90020989
Orthopnoea	191.77	10.26	227	575966	6608	90045646
Hepatic failure	189.45	10.26	620	575573	39108	90013146
Liver function test increased	188.82	10.26	157	576036	84698	89967556
Haematemesis	184.49	10.26	552	575641	33174	90019080
Subdural haematoma	184.19	10.26	358	575835	16287	90035967
Blood potassium increased	183.53	10.26	407	575786	20342	90031912
Prescribed underdose	183.34	10.26	126	576067	74893	89977361
Shock haemorrhagic	182.59	10.26	300	575893	11945	90040309
Hypovolaemia	181.93	10.26	302	575891	12129	90040125
Toxic epidermal necrolysis	181.36	10.26	536	575657	31992	90020262
Completed suicide	178.49	10.26	412	575781	144646	89907608
Injection site erythema	178.35	10.26	218	575975	98284	89953970
Hypocalcaemia	176.46	10.26	632	575561	41736	90010518
Respiratory distress	174.36	10.26	595	575598	38351	90013903
Exposure during pregnancy	173.31	10.26	852	575341	237558	89814696
General physical health deterioration	172.08	10.26	1437	574756	353678	89698576
Fatigue	170.23	10.26	5823	570370	1148200	88904054
Oliguria	168.94	10.26	268	575925	10356	90041898
Ischaemic stroke	167.77	10.26	409	575784	21757	90030497
Loss of consciousness	167.05	10.26	1490	574703	138748	89913506
Onychomycosis	165.72	10.26	21	576172	37355	90014899
Anuria	165.55	10.26	320	575873	14498	90037756
Taste disorder	164.74	10.26	93	576100	61453	89990801
Dyspepsia	162.06	10.26	678	575515	197482	89854772
Metabolic acidosis	159.80	10.26	740	575453	54936	89997318
Mobility decreased	159.57	10.26	937	575256	249797	89802457
Thrombocytopenia	156.59	10.26	2021	574172	206704	89845550
Joint stiffness	155.19	10.26	160	576033	77882	89974372
Adverse drug reaction	154.69	10.26	318	575875	116383	89935871
Laryngitis	153.59	10.26	65	576128	50688	90001566
Epilepsy	153.02	10.26	178	576015	82028	89970226
Product quality issue	152.85	10.26	167	576026	79158	89973096
Arrhythmia	151.87	10.26	602	575591	41730	90010524
Atrial flutter	151.63	10.26	257	575936	10501	90041753
Urinary tract infection	149.47	10.26	2752	573441	302880	89749374
Foot deformity	148.70	10.26	98	576095	59553	89992701
Cognitive disorder	148.66	10.26	850	575343	68557	89983697
Asthenia	148.45	10.26	4442	571751	529309	89522945
Gout	147.20	10.26	329	575864	16530	90035724
Haematuria	146.22	10.26	522	575671	34415	90017839
C-reactive protein increased	143.78	10.26	628	575565	180761	89871493
Brain natriuretic peptide increased	143.57	10.26	184	576009	5821	90046433
Atrioventricular block	142.42	10.26	224	575969	8591	90043663
Blood loss anaemia	141.29	10.26	241	575952	9899	90042355
Injection site pain	140.97	10.26	596	575597	173103	89879151
Atrioventricular block complete	140.44	10.26	236	575957	9575	90042679
Renal injury	139.50	10.26	241	575952	10002	90042252
Disability	138.87	10.26	43	576150	40702	90011552
Glomerular filtration rate decreased	138.50	10.26	322	575871	16610	90035644
Pseudo-Bartter syndrome	138.42	10.26	43	576150	58	90052196
Hyperuricaemia	137.79	10.26	191	576002	6528	90045726
Back injury	137.45	10.26	62	576131	46560	90005694
Toxic skin eruption	136.80	10.26	307	575886	15467	90036787
Cardiomyopathy	136.39	10.26	357	575836	19849	90032405
Constipation	135.43	10.26	2520	573673	277875	89774379
Blood sodium decreased	134.42	10.26	434	575759	27179	90025075
Electrolyte imbalance	134.02	10.26	393	575800	23352	90028902
Acute pulmonary oedema	133.89	10.26	228	575965	9352	90042902
Suicide attempt	133.22	10.26	170	576023	75229	89977025
Hypernatraemia	131.98	10.26	224	575969	9163	90043091
Colitis ulcerative	131.02	10.26	114	576079	60152	89992102
BRASH syndrome	130.85	10.26	103	576090	1776	90050478
Hypochloraemia	129.61	10.26	118	576075	2504	90049750
Pruritus	129.54	10.26	2545	573648	538980	89513274
Cardio-respiratory arrest	128.56	10.26	763	575430	62377	89989877
N-terminal prohormone brain natriuretic peptide increased	126.67	10.26	123	576070	2839	90049415
Rales	126.20	10.26	298	575895	15529	90036725
Red blood cell sedimentation rate abnormal	125.27	10.26	7	576186	24197	90028057
Intentional overdose	124.09	10.26	256	575937	93578	89958676
Upper gastrointestinal haemorrhage	123.73	10.26	374	575819	22602	90029652
Exostosis	121.08	10.26	96	576097	53038	89999216
Nephrocalcinosis	120.76	10.26	83	576110	1149	90051105
Blood alkaline phosphatase increased	120.71	10.26	615	575578	47464	90004790
Cerebral haemorrhage	120.68	10.26	487	575706	34035	90018219
Haemoptysis	120.46	10.26	475	575718	32845	90019409
Platelet count decreased	120.02	10.26	1366	574827	135603	89916651
Blood bilirubin increased	119.79	10.26	571	575622	42899	90009355
Prerenal failure	118.13	10.26	102	576091	2013	90050241
Injection site swelling	117.49	10.26	124	576069	59715	89992539
Joint dislocation	116.99	10.26	69	576124	44513	90007741
Ventricular fibrillation	116.98	10.26	269	575924	13775	90038479
Drug tolerance decreased	116.75	10.26	30	576163	32100	90020154
Shock	115.36	10.26	424	575769	28354	90023900
Sinus bradycardia	114.93	10.26	300	575893	16652	90035602
Bradyarrhythmia	114.37	10.26	107	576086	2354	90049900
Ear infection	112.55	10.26	168	576025	69607	89982647
Haemodialysis	110.34	10.26	199	575994	8548	90043706
Plasma cell myeloma	109.40	10.26	532	575661	40296	90011958
Loss of personal independence in daily activities	108.58	10.26	470	575723	135635	89916619
Abdominal pain upper	108.43	10.26	1476	574717	331198	89721056
Jaundice	108.36	10.26	452	575741	32065	90020189
Insomnia	108.17	10.26	1481	574712	331993	89720261
Haemorrhage	108.16	10.26	784	575409	68585	89983669
Pulmonary congestion	108.12	10.26	320	575873	19113	90033141
Lower gastrointestinal haemorrhage	107.99	10.26	199	575994	8693	90043561
Memory impairment	107.71	10.26	772	575421	196472	89855782
Prothrombin time prolonged	106.69	10.26	209	575984	9563	90042691
Pneumonia aspiration	106.52	10.26	529	575664	40411	90011843
Iron deficiency anaemia	106.35	10.26	362	575831	23300	90028954
Sudden death	105.66	10.26	222	575971	10687	90041567
Dialysis	105.62	10.26	227	575966	11102	90041152
Renal disorder	104.83	10.26	498	575695	37361	90014893
Diabetes mellitus inadequate control	104.27	10.26	308	575885	18376	90033878
Septic shock	103.18	10.26	900	575293	83260	89968994
Lethargy	102.16	10.26	720	575473	62419	89989835
Pulmonary arterial pressure increased	101.60	10.26	125	576068	3791	90048463
Injection site pruritus	98.65	10.26	118	576075	53716	89998538
Pemphigoid	98.49	10.26	193	576000	8833	90043421
Adverse reaction	98.35	10.26	33	576160	29679	90022575
Aspartate aminotransferase increased	97.22	10.26	1042	575151	101895	89950359
Hypovolaemic shock	96.73	10.26	167	576026	6927	90045327
Hyperglycaemia	95.59	10.26	603	575590	50367	90001887
Ejection fraction decreased	95.50	10.26	375	575818	25878	90026376
Hepatic function abnormal	95.29	10.26	561	575632	45727	90006527
Seronegative arthritis	95.22	10.26	5	576188	18229	90034025
Finger deformity	95.04	10.26	45	576148	32852	90019402
Rectal haemorrhage	94.85	10.26	872	575321	81872	89970382
Myelosuppression	94.49	10.26	121	576072	53470	89998784
Incorrect route of product administration	93.80	10.26	110	576083	50516	90001738
Walking aid user	93.10	10.26	55	576138	35451	90016803
Sedation	92.91	10.26	574	575619	47597	90004657
Head injury	92.81	10.26	419	575774	30769	90021485
Coagulopathy	92.41	10.26	342	575851	22947	90029307
Condition aggravated	91.35	10.26	2988	573205	592557	89459697
Congestive cardiomyopathy	91.10	10.26	166	576027	7188	90045066
Frequent bowel movements	90.94	10.26	138	576055	56797	89995457
Unevaluable event	90.23	10.26	628	575565	54220	89998034
Therapeutic response decreased	89.86	10.26	282	575911	89447	89962807
Weight increased	89.58	10.26	1999	574194	415928	89636326
Amnesia	89.44	10.26	370	575823	108135	89944119
Somnolence	89.37	10.26	1845	574348	207239	89845015
Left ventricular failure	89.11	10.26	156	576037	6544	90045710
Oedema	89.11	10.26	1778	574415	198517	89853737
Mental status changes	89.09	10.26	537	575656	44142	90008112
Myopathy	88.36	10.26	236	575957	13282	90038972
Headache	88.29	10.26	4535	571658	858211	89194043
Tricuspid valve incompetence	87.90	10.26	270	575923	16461	90035793
Multiple drug therapy	87.83	10.26	159	576034	6850	90045404
Maternal exposure timing unspecified	87.66	10.26	18	576175	22465	90029789
Muscle spasticity	86.73	10.26	59	576134	35263	90016991
Disorientation	85.92	10.26	527	575666	43587	90008667
Muscle haemorrhage	85.52	10.26	106	576087	3240	90049014
Faeces discoloured	85.36	10.26	314	575879	21006	90031248
Drug ineffective for unapproved indication	84.62	10.26	186	576007	66458	89985796
Sleep disorder due to a general medical condition	84.19	10.26	96	576097	44642	90007612
Cholestasis	84.01	10.26	454	575739	35845	90016409
Azotaemia	83.78	10.26	134	576059	5214	90047040
Abdominal wall haematoma	83.76	10.26	105	576088	3247	90049007
Aortic stenosis	82.29	10.26	146	576047	6190	90046064
Congestive hepatopathy	82.24	10.26	99	576094	2934	90049320
Ischaemic cardiomyopathy	82.09	10.26	92	576101	2521	90049733
Exercise tolerance decreased	81.84	10.26	161	576032	7390	90044864
Renal tubular necrosis	81.28	10.26	240	575953	14315	90037939
Lung disorder	79.23	10.26	592	575601	149291	89902963
Contusion	79.17	10.26	1122	575071	250094	89802160
Urinary tract discomfort	79.07	10.26	57	576136	855	90051399
International normalised ratio decreased	79.05	10.26	122	576071	4602	90047652
Interstitial lung disease	78.58	10.26	787	575406	75618	89976636
Encephalopathy	77.71	10.26	534	575659	45910	90006344
Aortic valve incompetence	77.64	10.26	146	576047	6478	90045776
Myocardial ischaemia	77.35	10.26	228	575965	13586	90038668
Intra-abdominal haematoma	76.99	10.26	81	576112	2063	90050191
Petechiae	76.25	10.26	247	575946	15494	90036760
Drug reaction with eosinophilia and systemic symptoms	75.97	10.26	499	575694	42259	90009995
Arteriosclerosis coronary artery	75.68	10.26	180	576013	9423	90042831
Therapy non-responder	75.61	10.26	533	575660	136171	89916083
Cardiac output decreased	75.56	10.26	58	576135	962	90051292
Cough	75.23	10.26	2963	573230	365999	89686255
No adverse event	75.10	10.26	204	575989	67778	89984476
Pancytopenia	74.95	10.26	1127	575066	119136	89933118
Rheumatoid nodule	74.88	10.26	18	576175	20148	90032106
Gastrointestinal tract mucosal pigmentation	74.82	10.26	50	576143	659	90051595
Polyuria	74.64	10.26	184	576009	9856	90042398
Sinus node dysfunction	74.57	10.26	128	576065	5284	90046970
Cor pulmonale	74.28	10.26	78	576115	1982	90050272
Agranulocytosis	73.85	10.26	427	575766	34575	90017679
Psoriasis	73.69	10.26	593	575600	147161	89905093
Pain in jaw	73.47	10.26	540	575653	47445	90004809
Liver function test abnormal	73.23	10.26	564	575629	50281	90001973
Ventricular arrhythmia	72.88	10.26	112	576081	4209	90048045
Accidental exposure to product	72.30	10.26	98	576095	42268	90009986
Concomitant disease aggravated	72.19	10.26	198	575995	11320	90040934
Hypophagia	71.69	10.26	432	575761	35505	90016749
Anxiety	70.59	10.26	1467	574726	308305	89743949
Alveolar osteitis	70.31	10.26	59	576134	1118	90051136
Dilatation ventricular	70.14	10.26	81	576112	2295	90049959
Wound secretion	70.05	10.26	119	576074	4871	90047383
Eosinophilia	68.85	10.26	361	575832	28172	90024082
Angina unstable	68.76	10.26	145	576048	6998	90045256
Tachypnoea	68.51	10.26	293	575900	21016	90031238
Depression	68.36	10.26	1424	574769	299177	89753077
Cerebral haematoma	67.93	10.26	108	576085	4181	90048073
Tunnel vision	67.84	10.26	68	576125	1633	90050621
Cardiac pacemaker insertion	67.10	10.26	109	576084	4298	90047956
Drug-induced liver injury	66.59	10.26	321	575872	89997	89962257
Blood glucose increased	66.28	10.26	910	575283	94336	89957918
Ecchymosis	65.79	10.26	200	575993	12123	90040131
Drug resistance	65.70	10.26	58	576135	30391	90021863
Atrioventricular block first degree	65.43	10.26	158	576035	8353	90043901
Blood albumin decreased	65.20	10.26	245	575948	16558	90035696
Liver disorder	64.55	10.26	478	575715	120791	89931463
Hallucination	64.29	10.26	672	575521	65287	89986967
Ventricular extrasystoles	63.36	10.26	207	575986	13043	90039211
Catheter management	63.30	10.26	87	576106	2949	90049305
Acidosis	62.73	10.26	201	575992	12535	90039719
Haematocrit decreased	62.48	10.26	468	575725	41364	90010890
Dermatitis exfoliative	62.39	10.26	120	576073	5416	90046838
Bundle branch block left	62.36	10.26	148	576045	7737	90044517
Diabetes mellitus	62.31	10.26	659	575534	64216	89988038
Nodal rhythm	62.30	10.26	67	576126	1751	90050503
Tubulointerstitial nephritis	62.09	10.26	322	575871	25021	90027233
Ear congestion	62.01	10.26	92	576101	3350	90048904
Arthritis	61.67	10.26	723	575470	166592	89885662
Transient ischaemic attack	61.66	10.26	478	575715	42698	90009556
Microcytic anaemia	61.65	10.26	97	576096	3721	90048533
Inappropriate schedule of product administration	61.59	10.26	632	575561	149301	89902953
Oxygen consumption increased	61.23	10.26	107	576086	4482	90047772
Acute coronary syndrome	61.05	10.26	179	576014	10634	90041620
Intestinal haemorrhage	61.04	10.26	105	576088	4342	90047912
Overdose	60.74	10.26	1371	574822	156338	89895916
Vital capacity decreased	60.52	10.26	66	576127	1753	90050501
Myoclonus	60.42	10.26	262	575931	18906	90033348
Subcutaneous haematoma	60.36	10.26	67	576126	1816	90050438
Coronary arterial stent insertion	60.15	10.26	82	576111	2758	90049496
Injection site bruising	60.03	10.26	154	576039	52153	90000101
Infusion site reaction	59.86	10.26	23	576170	19016	90033238
Prescribed overdose	59.85	10.26	369	575824	97256	89954998
Blood creatine increased	59.75	10.26	135	576058	6832	90045422
Altered state of consciousness	59.72	10.26	374	575819	31158	90021096
Foetal exposure during pregnancy	59.60	10.26	114	576079	42861	90009393
Blood iron decreased	59.34	10.26	249	575944	17710	90034544
International normalised ratio abnormal	58.41	10.26	95	576098	3750	90048504
Cyanosis	58.36	10.26	262	575931	19193	90033061
Normal newborn	57.39	10.26	39	576154	23323	90028931
Device difficult to use	57.08	10.26	20	576173	17505	90034749
Neck pain	57.00	10.26	457	575736	113506	89938748
Hypercapnia	56.84	10.26	129	576064	6548	90045706
Animal scratch	56.75	10.26	64	576129	1766	90050488
Fear	56.12	10.26	232	575961	16390	90035864
Concomitant disease progression	55.91	10.26	70	576123	2162	90050092
Catheter site infection	55.85	10.26	116	576077	5538	90046716
Disseminated intravascular coagulation	55.81	10.26	278	575915	21260	90030994
Dementia	55.60	10.26	299	575894	23562	90028692
Sputum culture positive	55.39	10.26	70	576123	2183	90050071
Circulatory collapse	55.30	10.26	308	575885	24596	90027658
Blood pressure inadequately controlled	54.94	10.26	122	576071	6102	90046152
Heparin-induced thrombocytopenia	54.86	10.26	111	576082	5201	90047053
Hyponatraemic syndrome	54.69	10.26	38	576155	536	90051718
Palpitations	54.66	10.26	1195	574998	135533	89916721
Dilatation atrial	54.27	10.26	65	576128	1916	90050338
Osteoporosis	54.04	10.26	375	575818	96156	89956098
Nephrotic syndrome	54.03	10.26	134	576059	7205	90045049
Jugular vein distension	53.66	10.26	49	576144	1044	90051210
Coronary artery bypass	53.08	10.26	70	576123	2279	90049975
Dysuria	52.87	10.26	430	575763	38971	90013283
Reversible airways obstruction	52.58	10.26	64	576129	1919	90050335
Activated partial thromboplastin time prolonged	52.55	10.26	138	576055	7687	90044567
Rash vesicular	52.40	10.26	25	576168	18172	90034082
Bronchitis	52.35	10.26	1308	574885	151619	89900635
Retroperitoneal haematoma	52.23	10.26	84	576109	3284	90048970
Cerebral infarction	51.96	10.26	318	575875	26278	90025976
Blood glucose decreased	51.52	10.26	289	575904	23140	90029114
Blood parathyroid hormone decreased	51.49	10.26	8	576185	12208	90040046
Coma	51.37	10.26	696	575497	71936	89980318
Therapeutic response shortened	51.30	10.26	42	576151	22837	90029417
Pustular psoriasis	51.17	10.26	27	576166	18529	90033725
Scleroderma	51.13	10.26	119	576074	6142	90046112
Gamma-glutamyltransferase increased	50.82	10.26	414	575779	37538	90014716
Hypoalbuminaemia	50.66	10.26	218	575975	15679	90036575
Gravitational oedema	50.62	10.26	50	576143	1179	90051075
Maternal exposure before pregnancy	50.44	10.26	6	576187	11207	90041047
Haemorrhage intracranial	49.92	10.26	210	575983	14952	90037302
Vaginal discharge	49.84	10.26	31	576162	19433	90032821
Staphylococcal sepsis	49.83	10.26	152	576041	9231	90043023
Hypoglycaemic coma	49.73	10.26	77	576116	2913	90049341
Arteriosclerosis	49.62	10.26	167	576026	10686	90041568
Drug tolerance	49.50	10.26	26	576167	17890	90034364
Chronic sinusitis	49.38	10.26	47	576146	23755	90028499
Gestational diabetes	49.28	10.26	5	576188	10577	90041677
Acute generalised exanthematous pustulosis	49.24	10.26	195	575998	13508	90038746
Cardiac valve disease	49.24	10.26	98	576095	4537	90047717
Joint destruction	49.06	10.26	12	576181	13275	90038979
Purpura	48.91	10.26	205	575988	14573	90037681
Haemorrhoidal haemorrhage	48.87	10.26	106	576087	5217	90047037
Lymphoedema	48.85	10.26	195	575998	13558	90038696
Asthma	48.81	10.26	1169	575024	240991	89811263
Visual impairment	48.76	10.26	572	575621	131793	89920461
Rash maculo-papular	48.74	10.26	435	575758	40498	90011756
Injection site urticaria	48.51	10.26	27	576166	17984	90034270
Nephropathy	48.48	10.26	149	576044	9086	90043168
Change of bowel habit	48.47	10.26	66	576127	2217	90050037
Dermatitis bullous	48.28	10.26	160	576033	10156	90042098
Bundle branch block right	48.26	10.26	107	576086	5346	90046908
Food allergy	48.13	10.26	302	575891	25176	90027078
Suicidal ideation	48.00	10.26	274	575919	73581	89978673
Extrasystoles	47.83	10.26	109	576084	5548	90046706
Thrombosis	47.80	10.26	692	575501	72559	89979695
Colitis microscopic	47.78	10.26	168	576025	10991	90041263
Injection site rash	47.55	10.26	50	576143	24123	90028131
Infective pulmonary exacerbation of cystic fibrosis	47.50	10.26	5	576188	10274	90041980
Multiple sclerosis relapse	47.17	10.26	172	576021	52133	90000121
Prothrombin time shortened	47.08	10.26	65	576128	2213	90050041
Device related infection	47.07	10.26	303	575890	25483	90026771
Pneumonia viral	46.92	10.26	143	576050	8680	90043574
Tenosynovitis	46.80	10.26	17	576176	14550	90037704
Occult blood positive	46.32	10.26	88	576105	3935	90048319
Soft tissue disorder	45.92	10.26	91	576102	4199	90048055
Peripartum cardiomyopathy	45.83	10.26	24	576169	194	90052060
Macular degeneration	45.75	10.26	109	576084	37861	90014393
Acne	45.62	10.26	69	576124	28438	90023816
Vaginal flatulence	45.54	10.26	12	576181	12626	90039628
Angina pectoris	45.53	10.26	414	575779	38746	90013508
Anhedonia	45.46	10.26	168	576025	11263	90040991
Anticoagulation drug level above therapeutic	45.29	10.26	60	576133	1962	90050292
Hypertension	45.11	10.26	2413	573780	455119	89597135
Female genital tract fistula	45.01	10.26	29	576164	17839	90034415
Decubitus ulcer	44.81	10.26	171	576022	11642	90040612
Paraesthesia oral	44.77	10.26	83	576110	31576	90020678
Troponin increased	44.55	10.26	185	576008	13096	90039158
Catheter site erythema	44.41	10.26	97	576096	4797	90047457
Nephropathy toxic	44.35	10.26	179	576014	12509	90039745
Temperature regulation disorder	44.23	10.26	197	575996	14382	90037872
Stevens-Johnson syndrome	44.06	10.26	329	575864	29047	90023207
General symptom	44.03	10.26	19	576174	14649	90037605
Wound complication	43.90	10.26	95	576098	4668	90047586
Ventricular hypertrophy	43.86	10.26	78	576115	3313	90048941
Clostridium difficile colitis	43.46	10.26	305	575888	26401	90025853
Gastric ulcer haemorrhage	43.43	10.26	101	576092	5210	90047044
Nephrogenic anaemia	43.12	10.26	65	576128	2401	90049853
Blood creatine phosphokinase increased	42.82	10.26	366	575827	33657	90018597
Oesophageal varices haemorrhage	42.60	10.26	50	576143	1442	90050812
Foetal death	42.54	10.26	251	575942	20472	90031782
Ischaemic hepatitis	42.41	10.26	69	576124	2724	90049530
Intentional self-injury	42.29	10.26	76	576117	29258	90022996
Low cardiac output syndrome	42.04	10.26	29	576164	404	90051850
Chronic respiratory failure	42.01	10.26	68	576125	2673	90049581
Drug level increased	41.69	10.26	311	575882	27451	90024803
Neurologic neglect syndrome	41.68	10.26	4	576189	8843	90043411
Limb injury	41.27	10.26	342	575851	31166	90021088
Breast cancer stage I	41.26	10.26	6	576187	9618	90042636
Metabolic encephalopathy	41.26	10.26	115	576078	6637	90045617
Haemorrhage subcutaneous	41.24	10.26	76	576117	3320	90048934
Bradyphrenia	41.07	10.26	124	576069	7488	90044766
Pulmonary embolism	41.01	10.26	1106	575087	129714	89922540
Blood chloride decreased	40.98	10.26	110	576083	6209	90046045
Hiatus hernia	40.90	10.26	289	575904	25072	90027182
Ear pain	40.85	10.26	208	575985	57494	89994760
Bladder pain	40.73	10.26	67	576126	2670	90049584
Deep vein thrombosis	40.60	10.26	813	575380	90807	89961447
Cardiac amyloidosis	40.56	10.26	41	576152	995	90051259
Hypothermia	40.33	10.26	201	575992	15374	90036880
Cardiopulmonary failure	40.29	10.26	85	576108	4103	90048151
Gastritis erosive	40.24	10.26	114	576079	6641	90045613
Dyspnoea at rest	40.16	10.26	92	576101	4699	90047555
Basal cell carcinoma	40.11	10.26	96	576097	33293	90018961
Acute respiratory distress syndrome	40.09	10.26	316	575877	28370	90023884
Enthesopathy	40.00	10.26	6	576187	9398	90042856
Duodenal ulcer haemorrhage	39.98	10.26	64	576129	2492	90049762
Feeling hot	39.84	10.26	311	575882	77697	89974557
Sinus arrest	39.58	10.26	58	576135	2088	90050166
Polyarthritis	39.53	10.26	35	576158	18315	90033939
Proctitis	39.50	10.26	24	576169	15235	90037019
Urine odour abnormal	39.08	10.26	118	576075	7126	90045128
Renal artery stenosis	38.95	10.26	58	576135	2119	90050135
Anaphylactic reaction	38.85	10.26	362	575831	87162	89965092
Inferior vena cava dilatation	38.70	10.26	17	576176	88	90052166
Peritonitis bacterial	38.69	10.26	95	576098	5076	90047178
Therapy partial responder	38.62	10.26	50	576143	21993	90030261
Haematoma muscle	38.55	10.26	53	576140	1797	90050457
Alkalosis	38.50	10.26	31	576162	553	90051701
Left ventricular dysfunction	38.48	10.26	190	576003	14479	90037775
Urosepsis	38.45	10.26	249	575944	20983	90031271
Obstructive airways disorder	38.39	10.26	289	575904	25580	90026674
Localised oedema	38.34	10.26	106	576087	6088	90046166
Product prescribing error	38.31	10.26	325	575868	29820	90022434
Diastolic dysfunction	38.20	10.26	118	576075	7215	90045039
Atrial enlargement	38.13	10.26	26	576167	355	90051899
Drug abuse	38.11	10.26	337	575856	82010	89970244
Pallor	38.11	10.26	358	575835	33807	90018447
Mitral valve stenosis	37.90	10.26	45	576148	1314	90050940
Venous pressure jugular increased	37.77	10.26	31	576162	569	90051685
Eosinophil count increased	37.62	10.26	174	576019	12907	90039347
Nasal congestion	37.57	10.26	742	575451	82672	89969582
Pulmonary alveolar haemorrhage	37.48	10.26	103	576090	5895	90046359
Heart rate increased	37.25	10.26	961	575232	111941	89940313
Skin laceration	37.04	10.26	288	575905	25747	90026507
Injection site warmth	37.03	10.26	34	576159	17481	90034773
Eye injury	36.89	10.26	12	576181	11008	90041246
Protein total decreased	36.86	10.26	114	576079	6975	90045279
Coronary artery occlusion	36.81	10.26	129	576064	8425	90043829
Gastric haemorrhage	36.73	10.26	114	576079	6989	90045265
Oral herpes	36.72	10.26	101	576092	33423	90018831
Cardiac operation	36.67	10.26	79	576114	3870	90048384
Hallucination, visual	36.57	10.26	262	575931	22830	90029424
Muscle spasms	36.57	10.26	1272	574921	250611	89801643
Psychotic disorder	36.57	10.26	91	576102	31139	90021115
Pancreatitis acute	36.56	10.26	338	575855	31777	90020477
Accidental overdose	36.56	10.26	306	575887	27967	90024287
Gastric ulcer	36.53	10.26	299	575894	27149	90025105
Catheter site pruritus	36.50	10.26	58	576135	2244	90050010
Haematotoxicity	36.43	10.26	17	576176	12518	90039736
Alanine aminotransferase increased	36.39	10.26	998	575195	117340	89934914
Rash erythematous	36.34	10.26	599	575594	64505	89987749
Supraventricular tachycardia	36.24	10.26	202	575991	16134	90036120
Ventricular dysfunction	36.22	10.26	76	576117	3655	90048599
Progressive multifocal leukoencephalopathy	36.02	10.26	28	576165	15627	90036627
Electrocardiogram ST segment abnormal	35.97	10.26	41	576152	1145	90051109
Lung infiltration	35.95	10.26	192	576001	15090	90037164
Feeling cold	35.91	10.26	298	575895	27167	90025087
Uveitis	35.89	10.26	29	576164	15874	90036380
Spondylitis	35.73	10.26	23	576170	14155	90038099
Diarrhoea	35.68	10.26	6632	569561	932558	89119696
Lung transplant	35.60	10.26	75	576118	3617	90048637
Hepatocellular carcinoma	35.55	10.26	59	576134	2369	90049885
Right atrial dilatation	35.27	10.26	33	576160	726	90051528
Hypoxic-ischaemic encephalopathy	35.18	10.26	86	576107	4582	90047672
Overlap syndrome	35.13	10.26	6	576187	8542	90043712
Vascular purpura	35.03	10.26	49	576144	1689	90050565
Ovarian cyst	35.00	10.26	35	576158	17283	90034971
Anti-neutrophil cytoplasmic antibody positive vasculitis	34.94	10.26	78	576115	3915	90048339
Catheterisation cardiac	34.93	10.26	89	576104	4867	90047387
Affect lability	34.82	10.26	38	576155	18025	90034229
Impaired work ability	34.73	10.26	43	576150	19283	90032971
Paracentesis	34.68	10.26	37	576156	958	90051296
Cardiorenal syndrome	34.67	10.26	39	576154	1073	90051181
Haemorrhagic diathesis	34.66	10.26	95	576098	5429	90046825
Pulmonary haemorrhage	34.62	10.26	121	576072	7892	90044362
Drug dose omission by device	34.50	10.26	11	576182	10220	90042034
Hepatitis fulminant	34.45	10.26	77	576116	3868	90048386
Hepatorenal syndrome	34.42	10.26	53	576140	1995	90050259
Haemorrhagic stroke	34.28	10.26	105	576088	6391	90045863
Chest pain	34.28	10.26	2416	573777	317229	89735025
Chromaturia	34.13	10.26	224	575969	18963	90033291
Uterine perforation	34.09	10.26	4	576189	7550	90044704
Dyspnoea paroxysmal nocturnal	33.88	10.26	38	576155	1042	90051212
Urinary retention	33.74	10.26	378	575815	37366	90014888
Spinal fusion surgery	33.68	10.26	18	576175	12265	90039989
Ammonia increased	33.55	10.26	88	576105	4898	90047356
Oxygen therapy	33.45	10.26	66	576127	3036	90049218
Gouty tophus	33.38	10.26	21	576172	248	90052006
Wound haemorrhage	33.36	10.26	63	576130	2804	90049450
Unresponsive to stimuli	33.28	10.26	380	575813	37741	90014513
Intestinal ischaemia	33.21	10.26	128	576065	8755	90043499
Thyroid disorder	33.09	10.26	210	575983	17575	90034679
Nephrosclerosis	33.09	10.26	39	576154	1130	90051124
Respiratory acidosis	32.86	10.26	120	576073	7999	90044255
Nodal arrhythmia	32.85	10.26	41	576152	1262	90050992
Wrong patient received product	32.79	10.26	70	576123	3407	90048847
Schizophrenia	32.67	10.26	28	576165	14886	90037368
Tumour lysis syndrome	32.56	10.26	149	576044	11003	90041251
Peripheral ischaemia	32.18	10.26	94	576099	5573	90046681
Pericardial haemorrhage	32.17	10.26	49	576144	1827	90050427
Endocarditis	32.12	10.26	109	576084	7004	90045250
Panniculitis	31.85	10.26	27	576166	14431	90037823
Gouty arthritis	31.79	10.26	28	576165	568	90051686
Embolic stroke	31.74	10.26	76	576117	3996	90048258
Ventricular hypokinesia	31.68	10.26	90	576103	5251	90047003
Coagulation time prolonged	31.64	10.26	46	576147	1644	90050610
Abdominal cavity drainage	31.57	10.26	25	576168	435	90051819
Pollakiuria	31.56	10.26	335	575858	32670	90019584
Calculus urinary	31.47	10.26	46	576147	1652	90050602
Right ventricular dysfunction	31.38	10.26	55	576138	2309	90049945
Retroperitoneal haemorrhage	31.38	10.26	64	576129	3016	90049238
Catheter site haemorrhage	31.37	10.26	71	576122	3597	90048657
Product complaint	31.34	10.26	169	576024	13331	90038923
Erythromelalgia	31.15	10.26	22	576171	319	90051935
Blood sodium increased	31.10	10.26	65	576128	3117	90049137
Full blood count decreased	31.09	10.26	307	575886	29382	90022872
Nodule	31.06	10.26	78	576115	26608	90025646
Continuous haemodiafiltration	31.00	10.26	34	576159	909	90051345
Bronchial secretion retention	30.95	10.26	70	576123	3545	90048709
Leukocytosis	30.79	10.26	317	575876	30673	90021581
Multiple-drug resistance	30.79	10.26	6	576187	7770	90044484
Vascular device infection	30.78	10.26	154	576039	11798	90040456
Haemoglobin increased	30.64	10.26	111	576082	7370	90044884
Catheter site discharge	30.63	10.26	55	576138	2354	90049900
Dry eye	30.51	10.26	229	575964	57702	89994552
Radiculopathy	30.38	10.26	44	576149	18461	90033793
Hip fracture	30.37	10.26	333	575860	32744	90019510
Personality disorder	30.27	10.26	21	576172	12423	90039831
Alkalosis hypochloraemic	30.15	10.26	19	576174	225	90052029
Subdural haemorrhage	30.11	10.26	67	576126	3356	90048898
Wrong patient	30.10	10.26	32	576161	825	90051429
Aspiration pleural cavity	30.07	10.26	33	576160	883	90051371
Catheter placement	30.04	10.26	56	576137	2468	90049786
Walking distance test abnormal	29.93	10.26	27	576166	566	90051688
Hypercreatininaemia	29.84	10.26	30	576163	723	90051531
Bradykinesia	29.76	10.26	103	576090	6685	90045569
Duodenal ulcer	29.68	10.26	130	576063	9422	90042832
Hypoacusis	29.66	10.26	289	575904	27561	90024693
Blood uric acid increased	29.62	10.26	112	576081	7592	90044662
Right-to-left cardiac shunt	29.40	10.26	20	576173	272	90051982
Haemorrhoids	29.38	10.26	279	575914	26423	90025831
Ischaemia	29.27	10.26	87	576106	5208	90047046
End stage renal disease	29.23	10.26	120	576073	8451	90043803
Aortic valve replacement	29.11	10.26	33	576160	916	90051338
Tachyarrhythmia	29.11	10.26	88	576105	5318	90046936
Blood lactate dehydrogenase increased	29.06	10.26	272	575921	25660	90026594
Complication of device insertion	29.05	10.26	15	576178	10421	90041833
Milk-alkali syndrome	28.86	10.26	38	576155	1235	90051019
Unintentional medical device removal	28.74	10.26	5	576188	7025	90045229
Red blood cell count decreased	28.72	10.26	434	575759	45917	90006337
Poor venous access	28.68	10.26	50	576143	19477	90032777
Urinary incontinence	28.65	10.26	365	575828	37201	90015053
Cardiac murmur	28.57	10.26	206	575987	17988	90034266
COVID-19	28.50	10.26	836	575357	168007	89884247
Left ventricular hypertrophy	28.49	10.26	95	576098	6049	90046205
Hepatomegaly	28.39	10.26	163	576030	13163	90039091
Hypokinesia	28.37	10.26	184	576009	15513	90036741
Bilirubin conjugated increased	28.36	10.26	62	576131	3068	90049186
Hepatorenal failure	28.05	10.26	28	576165	669	90051585
Mitral valve disease	27.92	10.26	55	576138	2527	90049727
Paranasal sinus discomfort	27.90	10.26	95	576098	6115	90046139
Exposure to toxic agent	27.89	10.26	8	576185	7959	90044295
Muscular weakness	27.88	10.26	1053	575140	205613	89846641
Mixed liver injury	27.81	10.26	109	576084	7514	90044740
Internal haemorrhage	27.81	10.26	95	576098	6125	90046129
Supraventricular extrasystoles	27.77	10.26	85	576108	5172	90047082
Hypocholesterolaemia	27.69	10.26	4	576189	6445	90045809
Dystonia	27.60	10.26	40	576153	16779	90035475
Ulcer haemorrhage	27.58	10.26	81	576112	26240	90026014
Hospitalisation	27.53	10.26	1035	575158	127065	89925189
Treatment noncompliance	27.43	10.26	472	575721	51255	90000999
Normochromic normocytic anaemia	27.42	10.26	83	576110	5019	90047235
Face oedema	27.35	10.26	247	575946	23071	90029183
Hypertrophic cardiomyopathy	27.23	10.26	50	576143	2178	90050076
Brain natriuretic peptide	27.22	10.26	10	576183	29	90052225
Hypertensive heart disease	27.06	10.26	55	576138	2585	90049669
Spontaneous haematoma	26.93	10.26	35	576158	1123	90051131
Abdominal hernia	26.93	10.26	90	576103	5738	90046516
Cardiac cirrhosis	26.86	10.26	16	576177	170	90052084
Pyrexia	26.85	10.26	3735	572458	656750	89395504
Abdominal distension	26.83	10.26	1050	575143	129551	89922703
Electrocardiogram U wave present	26.75	10.26	13	576180	88	90052166
Electrocardiogram abnormal	26.74	10.26	133	576060	10165	90042089
Adjustment disorder	26.63	10.26	14	576179	9628	90042626
Blood creatinine abnormal	26.59	10.26	72	576121	4085	90048169
Hypertensive crisis	26.57	10.26	199	575994	17585	90034669
Diabetic nephropathy	26.55	10.26	43	576150	1691	90050563
Staphylococcus test positive	26.54	10.26	74	576119	4271	90047983
Left ventricle outflow tract obstruction	26.52	10.26	22	576171	410	90051844
Pickwickian syndrome	26.35	10.26	21	576172	369	90051885
Pulmonary veno-occlusive disease	26.13	10.26	40	576153	1498	90050756
Asterixis	26.10	10.26	42	576151	1643	90050611
Device issue	26.06	10.26	98	576095	29439	90022815
Hypercalciuria	26.02	10.26	21	576172	376	90051878
Haemodynamic instability	25.94	10.26	145	576048	11594	90040660
Marasmus	25.89	10.26	29	576164	794	90051460
Troponin T increased	25.88	10.26	41	576152	1582	90050672
Throat irritation	25.87	10.26	192	576001	48503	90003751
Renal atrophy	25.85	10.26	44	576149	1804	90050450
Polymyalgia rheumatica	25.85	10.26	80	576113	4897	90047357
Catheter site pain	25.64	10.26	86	576107	5493	90046761
Hypochromic anaemia	25.63	10.26	48	576145	2123	90050131
Fear of injection	25.61	10.26	11	576182	8504	90043750
Coeliac disease	25.61	10.26	172	576021	44438	90007816
Peripheral embolism	25.44	10.26	37	576156	1323	90050931
Crystalluria	25.29	10.26	24	576169	538	90051716
Right ventricular enlargement	25.23	10.26	23	576170	489	90051765
Stasis dermatitis	25.23	10.26	31	576162	939	90051315
Drug monitoring procedure not performed	25.22	10.26	28	576165	759	90051495
Cardiac hypertrophy	24.93	10.26	34	576159	1144	90051110
Pharyngitis	24.88	10.26	65	576128	21882	90030372
Productive cough	24.85	10.26	654	575539	76409	89975845
Renal function test abnormal	24.78	10.26	101	576092	7090	90045164
Dermatitis atopic	24.76	10.26	72	576121	23400	90028854
Varices oesophageal	24.72	10.26	66	576127	3713	90048541
Peripheral arterial occlusive disease	24.67	10.26	75	576118	4546	90047708
Atrial septal defect repair	24.63	10.26	17	576176	237	90052017
Blood urea abnormal	24.53	10.26	30	576163	904	90051350
Right ventricular dilatation	24.49	10.26	41	576152	1658	90050596
Atrial thrombosis	24.49	10.26	48	576145	2197	90050057
Diverticulum	24.41	10.26	146	576047	11967	90040287
Bundle branch block	24.40	10.26	30	576163	909	90051345
Ovarian hyperstimulation syndrome	24.34	10.26	4	576189	5858	90046396
Disease recurrence	24.30	10.26	140	576053	37513	90014741
Hospice care	24.26	10.26	124	576069	9580	90042674
Haemorrhagic disorder	24.18	10.26	31	576162	981	90051273
Back pain	24.16	10.26	2336	573857	314839	89737415
Upper-airway cough syndrome	24.13	10.26	172	576021	14963	90037291
Diabetic hyperosmolar coma	23.97	10.26	20	576173	376	90051878
Cardioversion	23.80	10.26	36	576157	1334	90050920
Hepatotoxicity	23.76	10.26	182	576011	45660	90006594
Clostridium test positive	23.72	10.26	82	576111	5319	90046935
Respiration abnormal	23.70	10.26	107	576086	7856	90044398
Electrocardiogram repolarisation abnormality	23.68	10.26	36	576157	1340	90050914
Ureteric rupture	23.64	10.26	7	576186	7	90052247
Abnormal loss of weight	23.64	10.26	96	576097	6727	90045527
Pulmonary arterial pressure abnormal	23.62	10.26	24	576169	586	90051668
Atrioventricular block second degree	23.53	10.26	72	576121	4380	90047874
Peripheral circulatory failure	23.51	10.26	39	576154	1565	90050689
Cardiac tamponade	23.43	10.26	84	576109	5548	90046706
Vascular graft	23.39	10.26	28	576165	825	90051429
Portal hypertensive gastropathy	23.35	10.26	31	576162	1016	90051238
Amenorrhoea	23.33	10.26	24	576169	11698	90040556
Menstruation irregular	23.32	10.26	11	576182	8049	90044205
Basilar artery occlusion	23.29	10.26	15	576178	185	90052069
Oxygen saturation abnormal	23.27	10.26	70	576123	4218	90048036
Tongue oedema	23.25	10.26	82	576111	5372	90046882
Mitral valve replacement	23.18	10.26	22	576171	493	90051761
Pseudomonas infection	23.16	10.26	168	576025	14697	90037557
Craniocerebral injury	23.01	10.26	59	576134	3239	90049015
Skin turgor decreased	22.69	10.26	23	576170	560	90051694
Hypersensitivity vasculitis	22.67	10.26	68	576125	4091	90048163
Apnoea	22.64	10.26	119	576074	9295	90042959
Hyperthyroidism	22.53	10.26	196	575997	18114	90034140
Autoimmune haemolytic anaemia	22.48	10.26	83	576110	5562	90046692
Pulse absent	22.43	10.26	87	576106	5968	90046286
Gastroenteritis	22.29	10.26	284	575909	28945	90023309
Heart valve incompetence	22.28	10.26	59	576134	3303	90048951
Uraemic encephalopathy	22.15	10.26	17	576176	282	90051972
Pregnancy with contraceptive device	22.09	10.26	3	576190	5063	90047191
Ischaemic contracture of the left ventricle	22.08	10.26	13	576180	135	90052119
Alveolitis	22.07	10.26	55	576138	2966	90049288
Superinfection	22.05	10.26	56	576137	3056	90049198
Haemothorax	22.03	10.26	48	576145	2370	90049884
Long QT syndrome	22.00	10.26	66	576127	3971	90048283
Post procedural complication	21.97	10.26	201	575992	18841	90033413
Hyperprolactinaemia	21.92	10.26	4	576189	5429	90046825
Therapeutic embolisation	21.92	10.26	16	576177	245	90052009
Peripheral vascular disorder	21.90	10.26	90	576103	6341	90045913
Hepatitis	21.88	10.26	317	575876	70422	89981832
Volume blood decreased	21.86	10.26	15	576178	207	90052047
Ankylosing spondylitis	21.78	10.26	31	576162	13102	90039152
Arteriovenous malformation	21.72	10.26	37	576156	1518	90050736
Humerus fracture	21.71	10.26	121	576072	9664	90042590
Dysarthria	21.71	10.26	476	575717	54006	89998248
Infective exacerbation of chronic obstructive airways disease	21.61	10.26	36	576157	1450	90050804
Traumatic haematoma	21.58	10.26	40	576153	1755	90050499
Neonatal hypocalcaemia	21.58	10.26	8	576185	24	90052230
Carbon dioxide increased	21.57	10.26	41	576152	1834	90050420
Gastric varices	21.50	10.26	15	576178	213	90052041
Body mass index abnormal	21.49	10.26	25	576168	714	90051540
Dizziness postural	21.47	10.26	114	576079	8939	90043315
Malnutrition	21.47	10.26	196	575997	18362	90033892
Sight disability	21.44	10.26	13	576180	143	90052111
Mucosal dryness	21.42	10.26	56	576137	3111	90049143
Respiratory alkalosis	21.34	10.26	59	576134	3389	90048865
Generalised bullous fixed drug eruption	21.28	10.26	18	576175	345	90051909
Peripheral coldness	21.07	10.26	156	576037	13736	90038518
Toxicity to various agents	21.04	10.26	2114	574079	285732	89766522
Tetany	20.98	10.26	49	576144	2535	90049719
Cerebral venous thrombosis	20.96	10.26	46	576147	2282	90049972
Hepatojugular reflux	20.88	10.26	8	576185	27	90052227
Heart rate decreased	20.85	10.26	466	575727	53039	89999215
Gastric antral vascular ectasia	20.77	10.26	26	576167	803	90051451
Mood swings	20.76	10.26	65	576128	20637	90031617
Blood cholesterol decreased	20.72	10.26	41	576152	1890	90050364
Gastritis	20.72	10.26	377	575816	41376	90010878
Product administration error	20.69	10.26	258	575935	26165	90026089
Product storage error	20.69	10.26	63	576130	20178	90032076
Potentiating drug interaction	20.69	10.26	81	576112	5581	90046673
Gastric mucosal hypertrophy	20.69	10.26	11	576182	92	90052162
Pulmonary hypoplasia	20.69	10.26	18	576175	359	90051895
Scleritis	20.66	10.26	4	576189	5204	90047050
Brain natriuretic peptide abnormal	20.65	10.26	19	576174	409	90051845
Complication of device removal	20.61	10.26	7	576186	6248	90046006
Sexual dysfunction	20.58	10.26	3	576190	4801	90047453
Angiopathy	20.52	10.26	79	576114	5401	90046853
Skin ulcer	20.43	10.26	439	575754	49636	90002618
Maternal exposure during breast feeding	20.43	10.26	7	576186	6213	90046041
Ventricular dyssynchrony	20.42	10.26	10	576183	69	90052185
Device dislocation	20.34	10.26	117	576076	31365	90020889
Portal hypertension	20.32	10.26	71	576122	4630	90047624
Schizoaffective disorder	20.32	10.26	4	576189	5143	90047111
Oesophageal spasm	20.29	10.26	57	576136	3304	90048950
Hyperbilirubinaemia	20.29	10.26	155	576038	13781	90038473
Hyperamylasaemia	20.27	10.26	21	576172	525	90051729
Peritonitis	20.26	10.26	203	575990	19502	90032752
Tracheostomy	20.16	10.26	24	576169	703	90051551
Ear pruritus	20.12	10.26	9	576184	6794	90045460
Antibiotic level above therapeutic	20.03	10.26	20	576173	478	90051776
Retching	20.01	10.26	198	575995	18961	90033293
Heart transplant	19.97	10.26	22	576171	591	90051663
Endocarditis enterococcal	19.79	10.26	15	576178	244	90052010
Gastrointestinal angiodysplasia	19.77	10.26	22	576171	598	90051656
Anaemia macrocytic	19.72	10.26	69	576124	4503	90047751
Hyperglycaemic hyperosmolar nonketotic syndrome	19.69	10.26	33	576160	1336	90050918
Medical device site thrombosis	19.61	10.26	10	576183	76	90052178
Thalamic infarction	19.57	10.26	20	576173	492	90051762
Localised infection	19.55	10.26	311	575882	33251	90019003
Lymphorrhoea	19.55	10.26	9	576184	53	90052201
Splenomegaly	19.53	10.26	145	576048	12779	90039475
Nephrogenic systemic fibrosis	19.48	10.26	64	576129	4044	90048210
Erysipelas	19.47	10.26	111	576082	8941	90043313
Mouth haemorrhage	19.45	10.26	106	576087	8395	90043859
Catheter site rash	19.41	10.26	25	576168	795	90051459
Pelvic pain	19.38	10.26	43	576150	15314	90036940
Aortic valve calcification	19.37	10.26	22	576171	612	90051642
Postpericardiotomy syndrome	19.35	10.26	6	576187	8	90052246
Catheter site inflammation	19.32	10.26	27	576166	930	90051324
Gastrointestinal toxicity	19.28	10.26	19	576174	9448	90042806
Serositis	19.28	10.26	32	576161	1285	90050969
Chronic left ventricular failure	19.25	10.26	22	576171	616	90051638
Infected skin ulcer	19.20	10.26	48	576145	2594	90049660
Pain in extremity	19.19	10.26	2540	573653	447989	89604265
Body height decreased	19.17	10.26	136	576057	11813	90040441
Gastrooesophageal reflux disease	19.14	10.26	863	575330	165474	89886780
Fibromuscular dysplasia	19.12	10.26	16	576177	302	90051952
Hyperaesthesia	19.03	10.26	24	576169	10678	90041576
Nasal oedema	19.03	10.26	9	576184	6575	90045679
Aplastic anaemia	19.00	10.26	147	576046	13122	90039132
Post procedural haemorrhage	19.00	10.26	108	576085	8690	90043564
Device deployment issue	18.99	10.26	4	576189	4905	90047349
Cardiac death	18.98	10.26	21	576172	567	90051687
Nausea	18.89	10.26	6552	569641	1103764	88948490
Emotional distress	18.89	10.26	333	575860	36329	90015925
Pulmonary artery dilatation	18.86	10.26	17	576176	356	90051898
Vitamin B1 deficiency	18.83	10.26	19	576174	460	90051794
Angiodermatitis	18.79	10.26	13	576180	182	90052072
Acute motor-sensory axonal neuropathy	18.78	10.26	17	576176	358	90051896
Transplant evaluation	18.76	10.26	32	576161	1314	90050940
Systolic dysfunction	18.73	10.26	39	576154	1865	90050389
Hypoproteinaemia	18.69	10.26	53	576140	3089	90049165
Chronic hepatic failure	18.68	10.26	22	576171	637	90051617
Fryns syndrome	18.63	10.26	9	576184	60	90052194
Eye pain	18.61	10.26	185	576008	43983	90008271
Hyperaldosteronism	18.60	10.26	16	576177	314	90051940
Breast cancer female	18.52	10.26	42	576151	14844	90037410
Eye irritation	18.52	10.26	133	576060	33845	90018409
Cerebral mass effect	18.50	10.26	28	576165	1038	90051216
Febrile neutropenia	18.33	10.26	821	575372	157528	89894726
Blood potassium abnormal	18.30	10.26	51	576142	2943	90049311
Nasal mucosal erosion	18.27	10.26	9	576184	63	90052191
Haemorrhagic transformation stroke	18.26	10.26	31	576162	1268	90050986
Somatic delusion	18.24	10.26	21	576172	593	90051661
Creatinine renal clearance increased	18.22	10.26	54	576139	3227	90049027
Immune reconstitution inflammatory syndrome	18.22	10.26	11	576182	7008	90045246
Thermohypoaesthesia	18.07	10.26	11	576182	122	90052132
Catheter removal	18.06	10.26	17	576176	377	90051877
Cystostomy	18.03	10.26	9	576184	65	90052189
Intestinal pseudo-obstruction	18.03	10.26	29	576164	1134	90051120
Gastric polyps	18.03	10.26	68	576125	4604	90047650
Diabetic metabolic decompensation	18.00	10.26	39	576154	1918	90050336
Cardiac rehabilitation therapy	17.99	10.26	5	576188	3	90052251
Ocular icterus	17.98	10.26	61	576132	3919	90048335
Escherichia sepsis	17.95	10.26	79	576114	5737	90046517
Asphyxia	17.92	10.26	91	576102	7012	90045242
Cerebellar haematoma	17.84	10.26	17	576176	383	90051871
Hyperhidrosis	17.81	10.26	1048	575145	135257	89916997
Prothrombin level decreased	17.76	10.26	22	576171	672	90051582
Refusal of treatment by patient	17.76	10.26	78	576115	5660	90046594
Amyloidosis	17.69	10.26	30	576163	1226	90051028
Proteinuria	17.64	10.26	226	575967	23065	90029189
Small for dates baby	17.58	10.26	5	576188	5002	90047252
Blood phosphorus decreased	17.58	10.26	71	576122	4963	90047291
Haemolytic anaemia	17.54	10.26	131	576062	11566	90040688
Pyelonephritis	17.50	10.26	210	575983	21106	90031148
Hypoaldosteronism	17.44	10.26	16	576177	343	90051911
Electrocardiogram T wave peaked	17.42	10.26	14	576179	249	90052005
Rectosigmoid cancer	17.38	10.26	13	576180	207	90052047
Catheter site irritation	17.38	10.26	21	576172	625	90051629
Optic ischaemic neuropathy	17.37	10.26	36	576157	1716	90050538
Cardiothoracic ratio increased	17.36	10.26	7	576186	28	90052226
Cutaneous vasculitis	17.35	10.26	91	576102	7102	90045152
Blood magnesium decreased	17.28	10.26	164	576029	15529	90036725
Hyperparathyroidism primary	17.25	10.26	18	576175	454	90051800
Nocturnal dyspnoea	17.20	10.26	32	576161	1408	90050846
Streptococcal sepsis	17.14	10.26	56	576137	3528	90048726
Flushing	17.14	10.26	707	575486	87784	89964470
Platelet dysfunction	17.13	10.26	10	576183	102	90052152
Gastrointestinal vascular malformation haemorrhagic	17.12	10.26	13	576180	212	90052042
Myalgia	17.11	10.26	1314	574879	173811	89878443
Right ventricular systolic pressure increased	17.09	10.26	20	576173	575	90051679
Disturbance in social behaviour	17.08	10.26	3	576190	4185	90048069
Renal tubular disorder	17.07	10.26	52	576141	3155	90049099
Arrhythmia supraventricular	17.05	10.26	28	576165	1114	90051140
Skin graft failure	17.05	10.26	10	576183	103	90052151
Heart sounds	17.02	10.26	28	576165	1116	90051138
Acute left ventricular failure	17.01	10.26	30	576163	1266	90050988
Bleeding varicose vein	16.99	10.26	16	576177	355	90051899
Hepatic hydrothorax	16.99	10.26	8	576185	50	90052204
Demyelination	16.97	10.26	16	576177	8124	90044130
Biopsy liver	16.97	10.26	17	576176	408	90051846
Heart rate irregular	16.93	10.26	232	575961	24036	90028218
Cardiac valve replacement complication	16.92	10.26	11	576182	138	90052116
Tendonitis	16.91	10.26	74	576119	21298	90030956
Cardiac ablation	16.88	10.26	35	576158	1669	90050585
Hepatitis C	16.81	10.26	76	576117	5584	90046670
Inability to afford medication	16.79	10.26	56	576137	3566	90048688
Deafness bilateral	16.75	10.26	35	576158	1678	90050576
Diabetic foot	16.75	10.26	34	576159	1597	90050657
Device alarm issue	16.70	10.26	37	576156	1848	90050406
Anaemia of chronic disease	16.67	10.26	45	576148	2548	90049706
Cardiac function test abnormal	16.66	10.26	9	576184	78	90052176
Systolic anterior motion of mitral valve	16.63	10.26	7	576186	32	90052222
Angioplasty	16.62	10.26	32	576161	1445	90050809
Sleep apnoea syndrome	16.58	10.26	289	575904	31458	90020796
Pseudoporphyria	16.57	10.26	14	576179	268	90051986
Extradural haematoma	16.55	10.26	39	576154	2029	90050225
Mechanical ventilation	16.55	10.26	32	576161	1450	90050804
Hypermagnesaemia	16.50	10.26	29	576164	1220	90051034
Oesophagitis	16.46	10.26	175	576018	17074	90035180
Synovial cyst	16.45	10.26	31	576162	11721	90040533
Blood glucose fluctuation	16.42	10.26	70	576123	5013	90047241
Base excess negative	16.42	10.26	5	576188	6	90052248
Spinal compression fracture	16.41	10.26	158	576035	15020	90037234
Neonatal gastrointestinal disorder	16.37	10.26	9	576184	81	90052173
Prolonged expiration	16.37	10.26	29	576164	1228	90051026
Toxic encephalopathy	16.36	10.26	103	576090	8596	90043658
Bone density decreased	16.33	10.26	56	576137	17289	90034965
Cholecystitis	16.31	10.26	173	576020	16867	90035387
Rectal prolapse	16.28	10.26	41	576152	2226	90050028
Electrocardiogram ST-T segment depression	16.26	10.26	4	576189	0	90052254
Decreased appetite	16.18	10.26	2677	573516	373863	89678391
Micturition disorder	16.11	10.26	49	576144	2971	90049283
Food refusal	16.04	10.26	20	576173	615	90051639
Puncture site haemorrhage	16.04	10.26	16	576177	382	90051872
Left atrial dilatation	16.03	10.26	37	576156	1899	90050355
Myositis	15.95	10.26	89	576104	24039	90028215
Cystitis escherichia	15.94	10.26	21	576172	683	90051571
Adrenal insufficiency	15.88	10.26	118	576075	29803	90022451
Multimorbidity	15.87	10.26	20	576173	622	90051632
Mucosal inflammation	15.87	10.26	264	575929	57361	89994893
Rash morbilliform	15.84	10.26	59	576134	3970	90048284
Serotonin syndrome	15.84	10.26	159	576034	37728	90014526
Hyperlactacidaemia	15.79	10.26	60	576133	4076	90048178
Pelvic fracture	15.75	10.26	157	576036	15062	90037192
Pulmonary vein stenosis	15.74	10.26	9	576184	88	90052166
Blood aldosterone increased	15.74	10.26	12	576181	197	90052057
Senile dementia	15.73	10.26	13	576180	241	90052013
Cardiac failure high output	15.72	10.26	17	576176	447	90051807
Fluid intake reduced	15.66	10.26	60	576133	4092	90048162
Fibrin degradation products increased	15.66	10.26	11	576182	158	90052096
Multiple sclerosis	15.65	10.26	108	576085	27732	90024522
Back disorder	15.64	10.26	97	576096	25534	90026720
Urine sodium decreased	15.60	10.26	11	576182	159	90052095
Tongue coated	15.60	10.26	34	576159	1679	90050575
Drug use disorder	15.59	10.26	18	576175	8325	90043929
Myocardial necrosis	15.59	10.26	12	576181	200	90052054
Ventricular hyperkinesia	15.56	10.26	8	576185	62	90052192
Cirrhosis alcoholic	15.54	10.26	14	576179	293	90051961
Bronchopulmonary aspergillosis allergic	15.53	10.26	56	576137	3710	90048544
Drug dispensed to wrong patient	15.53	10.26	15	576178	344	90051910
Angiotensin converting enzyme inhibitor foetopathy	15.52	10.26	7	576186	39	90052215
Myoglobin blood increased	15.52	10.26	32	576161	1520	90050734
Blood creatine phosphokinase MB increased	15.50	10.26	28	576165	1204	90051050
Gastric varices haemorrhage	15.49	10.26	11	576182	161	90052093
Hypoprothrombinaemia	15.48	10.26	16	576177	399	90051855
Prothrombin time abnormal	15.48	10.26	18	576175	514	90051740
Creatinine urine decreased	15.42	10.26	14	576179	296	90051958
Deformity	15.42	10.26	34	576159	12136	90040118
Lip erosion	15.40	10.26	28	576165	1210	90051044
Product preparation error	15.32	10.26	26	576167	10235	90042019
Essential hypertension	15.31	10.26	80	576113	6235	90046019
Cerebellar haemorrhage	15.27	10.26	33	576160	1620	90050634
Appetite disorder	15.27	10.26	105	576088	9028	90043226
Asthma-chronic obstructive pulmonary disease overlap syndrome	15.27	10.26	6	576187	4893	90047361
Pneumonia bacterial	15.27	10.26	136	576057	12654	90039600
Clostridium difficile infection	15.19	10.26	319	575874	35926	90016328
Anal incontinence	15.18	10.26	164	576029	16066	90036188
Transcription medication error	15.16	10.26	13	576180	254	90052000
Congenital nail disorder	15.16	10.26	9	576184	95	90052159
International normalised ratio	15.16	10.26	9	576184	95	90052159
Blood pressure systolic decreased	15.16	10.26	106	576087	9164	90043090
Coronary artery stenosis	15.11	10.26	70	576123	5196	90047058
PO2 decreased	15.11	10.26	32	576161	1549	90050705
Colitis ischaemic	15.11	10.26	132	576061	12214	90040040
Scleroedema	15.08	10.26	10	576183	130	90052124
Gingival bleeding	15.07	10.26	153	576040	14750	90037504
Congenital anomaly	15.06	10.26	11	576182	6336	90045918
Inflammatory bowel disease	15.05	10.26	7	576186	5164	90047090
Limb hypoplasia congenital	15.05	10.26	12	576181	211	90052043
Paradoxical drug reaction	15.02	10.26	9	576184	5757	90046497
Parkinsonism	15	10.26	146	576047	13919	90038335
Blood parathyroid hormone increased	14.94	10.26	52	576141	3385	90048869
Glomerulonephritis acute	14.92	10.26	9	576184	98	90052156
Rectal polyp	14.91	10.26	26	576167	1087	90051167
Breast cancer	14.90	10.26	246	575947	53515	89998739
Pneumonia staphylococcal	14.89	10.26	54	576139	3587	90048667
Labelled drug-drug interaction medication error	14.89	10.26	150	576043	14432	90037822
Pericardial excision	14.88	10.26	6	576187	24	90052230
Peripheral artery thrombosis	14.87	10.26	39	576154	2171	90050083
Hypocoagulable state	14.86	10.26	32	576161	1567	90050687
Fibrosis	14.84	10.26	76	576117	5876	90046378
Platelet transfusion	14.79	10.26	26	576167	1094	90051160
Device pacing issue	14.77	10.26	9	576184	100	90052154
Blood lactic acid increased	14.72	10.26	101	576092	8677	90043577
Drug therapeutic incompatibility	14.70	10.26	7	576186	45	90052209
Pseudomembranous colitis	14.68	10.26	56	576137	3812	90048442
Central venous catheterisation	14.67	10.26	45	576148	2741	90049513
Haemarthrosis	14.48	10.26	57	576136	3937	90048317
Sickle cell anaemia with crisis	14.46	10.26	15	576178	7282	90044972
Colon cancer	14.44	10.26	119	576074	10825	90041429
Lupus nephritis	14.44	10.26	65	576128	4767	90047487
Clostridial sepsis	14.40	10.26	18	576175	555	90051699
Organ failure	14.39	10.26	48	576145	3057	90049197
Catarrh	14.39	10.26	32	576161	1602	90050652
Central nervous system lesion	14.38	10.26	33	576160	11613	90040641
Sneezing	14.37	10.26	121	576072	29748	90022506
Malignant neoplasm progression	14.30	10.26	545	575648	106325	89945929
Right atrial pressure increased	14.28	10.26	10	576183	143	90052111
Cystitis klebsiella	14.27	10.26	12	576181	228	90052026
Pupillary reflex impaired	14.24	10.26	42	576151	2503	90049751
Delirium	14.22	10.26	531	575662	103828	89948426
Hepatocellular injury	14.20	10.26	261	575932	28697	90023557
Gastrointestinal necrosis	14.19	10.26	49	576144	3176	90049078
Small intestinal haemorrhage	14.19	10.26	39	576154	2232	90050022
QRS axis abnormal	14.15	10.26	27	576166	1211	90051043
Electrocardiogram QT shortened	14.15	10.26	11	576182	186	90052068
Atelectasis	14.15	10.26	226	575967	24183	90028071
Device use error	14.13	10.26	15	576178	7206	90045048
Pharyngeal swelling	14.12	10.26	26	576167	9918	90042336
Hypokalaemic syndrome	14.11	10.26	9	576184	109	90052145
Compression fracture	14.08	10.26	100	576093	8689	90043565
Troponin	14.04	10.26	4	576189	3	90052251
Blood antidiuretic hormone increased	14.04	10.26	4	576189	3	90052251
General physical condition abnormal	13.98	10.26	67	576126	5044	90047210
Capillary leak syndrome	13.93	10.26	44	576149	2723	90049531
Mouth swelling	13.91	10.26	72	576121	5590	90046664
Systemic scleroderma	13.86	10.26	31	576162	1558	90050696
Neonatal cholestasis	13.86	10.26	7	576186	52	90052202
Mallory-Weiss syndrome	13.86	10.26	32	576161	1643	90050611
Pulmonary arterial wedge pressure increased	13.86	10.26	15	576178	395	90051859
Hypochromasia	13.84	10.26	14	576179	340	90051914
Drug specific antibody present	13.82	10.26	9	576184	5505	90046749
Diabetic foot infection	13.81	10.26	12	576181	239	90052015
Cerebral hypoperfusion	13.80	10.26	15	576178	397	90051857
Myxoedema coma	13.80	10.26	15	576178	397	90051857
Pulmonary valve incompetence	13.78	10.26	32	576161	1649	90050605
Haemoconcentration	13.76	10.26	10	576183	152	90052102
Brain compression	13.76	10.26	17	576176	518	90051736
Erythrodermic psoriasis	13.74	10.26	25	576168	1081	90051173
Blood pH increased	13.74	10.26	19	576174	648	90051606
Stupor	13.67	10.26	70	576123	5412	90046842
Chest discomfort	13.65	10.26	1039	575154	137326	89914928
Pulmonary hypertensive crisis	13.64	10.26	16	576177	461	90051793
Arteriovenous fistula operation	13.64	10.26	12	576181	243	90052011
Urine albumin/creatinine ratio abnormal	13.64	10.26	9	576184	116	90052138
Catheterisation cardiac abnormal	13.64	10.26	13	576180	293	90051961
Sudden cardiac death	13.62	10.26	38	576155	2194	90050060
Neuroglycopenia	13.60	10.26	25	576168	1090	90051164
Hypoglycaemic unconsciousness	13.59	10.26	21	576172	793	90051461
Face injury	13.58	10.26	55	576138	3850	90048404
Peau d'orange	13.57	10.26	9	576184	117	90052137
Proteus infection	13.57	10.26	30	576163	1496	90050758
Mitral valve calcification	13.54	10.26	26	576167	1172	90051082
Biliary catheter insertion	13.52	10.26	6	576187	32	90052222
Coordination abnormal	13.46	10.26	80	576113	21276	90030978
Stress cardiomyopathy	13.45	10.26	137	576056	13218	90039036
Aplasia pure red cell	13.43	10.26	67	576126	5127	90047127
Inappropriate antidiuretic hormone secretion	13.42	10.26	186	576007	19319	90032935
Urinary tract candidiasis	13.40	10.26	20	576173	732	90051522
Impaired quality of life	13.40	10.26	89	576104	23055	90029199
Diffuse large B-cell lymphoma recurrent	13.38	10.26	3	576190	3523	90048731
Anosognosia	13.36	10.26	3	576190	3519	90048735
Dactylitis	13.35	10.26	4	576189	3869	90048385
Abdominal sepsis	13.33	10.26	29	576164	1430	90050824
Blood fibrinogen increased	13.28	10.26	22	576171	882	90051372
Urine chloride decreased	13.27	10.26	8	576185	87	90052167
Device related sepsis	13.23	10.26	63	576130	4730	90047524
Myocardial necrosis marker increased	13.21	10.26	37	576156	2141	90050113
Hypercalcaemia of malignancy	13.13	10.26	12	576181	256	90051998
Pulmonary resection	13.12	10.26	7	576186	59	90052195
Blood sodium abnormal	13.11	10.26	21	576172	818	90051436
Diaphragmatic paralysis	13.11	10.26	19	576174	677	90051577
Glomerulonephritis	13.10	10.26	40	576153	2430	90049824
Limb reduction defect	13.10	10.26	18	576175	610	90051644
Intra-abdominal haemorrhage	13.10	10.26	42	576151	2620	90049634
Hyperosmolar state	13.09	10.26	12	576181	257	90051997
Dissociation	13.08	10.26	14	576179	6701	90045553
Arterial fibrosis	13.05	10.26	4	576189	5	90052249
Peptic ulcer	13.02	10.26	69	576124	5406	90046848
Tooth infection	13.01	10.26	75	576118	20095	90032159
Cleft palate	13.00	10.26	27	576166	1289	90050965
Congenital oral malformation	13.00	10.26	11	576182	211	90052043
Dementia Alzheimer's type	12.92	10.26	23	576170	978	90051276
Stent placement	12.90	10.26	57	576136	4146	90048108
Large intestine polyp	12.90	10.26	103	576090	9283	90042971
Menstrual disorder	12.87	10.26	12	576181	6126	90046128
Rib fracture	12.87	10.26	238	575955	26197	90026057
Hypoglobulinaemia	12.87	10.26	10	576183	169	90052085
Human herpesvirus 6 infection	12.87	10.26	3	576190	3429	90048825
Electrocardiogram T wave abnormal	12.86	10.26	42	576151	2646	90049608
Carbon dioxide abnormal	12.83	10.26	11	576182	215	90052039
Enterococcus test positive	12.82	10.26	27	576166	1302	90050952
Right atrial enlargement	12.79	10.26	11	576182	216	90052038
Pharyngitis streptococcal	12.78	10.26	40	576153	12702	90039552
Bleeding time prolonged	12.77	10.26	18	576175	625	90051629
Injection site mass	12.76	10.26	85	576108	22005	90030249
Cyanosis central	12.75	10.26	8	576185	94	90052160
Bacteraemia	12.75	10.26	206	575987	22094	90030160
Cerebral artery embolism	12.72	10.26	23	576170	990	90051264
Varicose vein	12.70	10.26	85	576108	7242	90045012
Thrombocytopenic purpura	12.68	10.26	33	576160	1828	90050426
Sputum culture	12.68	10.26	13	576180	321	90051933
Lipase increased	12.68	10.26	117	576076	10994	90041260
Aortic valve stenosis	12.64	10.26	57	576136	4183	90048071
Rheumatic heart disease	12.60	10.26	5	576188	19	90052235
Galactorrhoea	12.59	10.26	7	576186	4665	90047589
Muscle twitching	12.58	10.26	96	576097	24106	90028148
Iatrogenic injury	12.58	10.26	21	576172	847	90051407
Prurigo	12.56	10.26	22	576171	923	90051331
Haemorrhoid operation	12.55	10.26	15	576178	441	90051813
Poisoning deliberate	12.50	10.26	58	576135	16428	90035826
Calcification metastatic	12.49	10.26	10	576183	177	90052077
Chemical burn of oral cavity	12.46	10.26	7	576186	66	90052188
Rehabilitation therapy	12.44	10.26	34	576159	1940	90050314
Cardiac aneurysm	12.41	10.26	23	576170	1009	90051245
Patent ductus arteriosus repair	12.40	10.26	5	576188	20	90052234
Oral candidiasis	12.37	10.26	155	576038	35300	90016954
Therapy change	12.37	10.26	93	576100	8229	90044025
Faeces hard	12.35	10.26	47	576146	3195	90049059
Hepatitis cholestatic	12.34	10.26	95	576098	8466	90043788
Congenital diaphragmatic hernia	12.33	10.26	11	576182	227	90052027
Pre-eclampsia	12.31	10.26	33	576160	11015	90041239
Hyporeflexia	12.31	10.26	37	576156	2229	90050025
Body mass index decreased	12.29	10.26	16	576177	514	90051740
Incorrect dose administered by device	12.29	10.26	11	576182	5726	90046528
Sputum retention	12.28	10.26	18	576175	648	90051606
Respiratory fremitus	12.26	10.26	4	576189	7	90052247
Blood pressure diastolic abnormal	12.25	10.26	75	576118	19806	90032448
Dizziness exertional	12.25	10.26	16	576177	516	90051738
Tongue dry	12.23	10.26	25	576168	1180	90051074
Leukaemic infiltration renal	12.21	10.26	5	576188	21	90052233
Conjunctival haemorrhage	12.21	10.26	54	576139	3930	90048324
Urine chloride increased	12.19	10.26	3	576190	0	90052254
Benign small intestinal neoplasm	12.19	10.26	3	576190	0	90052254
Oedema due to renal disease	12.19	10.26	3	576190	0	90052254
Implantable cardiac monitor insertion	12.19	10.26	3	576190	0	90052254
Tracheal operation	12.19	10.26	3	576190	0	90052254
Cardiovascular insufficiency	12.19	10.26	30	576163	1605	90050649
Chronic myeloid leukaemia	12.18	10.26	41	576152	2623	90049631
Anal abscess	12.16	10.26	11	576182	5697	90046557
Cardioactive drug level above therapeutic	12.16	10.26	9	576184	141	90052113
Genital haemorrhage	12.14	10.26	23	576170	8679	90043575
Ulcer	12.14	10.26	142	576051	32740	90019514
Polypectomy	12.13	10.26	23	576170	1027	90051227
Immobilisation syndrome	12.11	10.26	15	576178	458	90051796
Upper respiratory tract inflammation	12.11	10.26	41	576152	2631	90049623
Pneumonia klebsiella	12.09	10.26	45	576148	3027	90049227
Catheter site swelling	12.07	10.26	32	576161	1793	90050461
Premature labour	12.05	10.26	44	576149	13332	90038922
Haemolysis	12.03	10.26	94	576099	8416	90043838
Hypomania	11.99	10.26	24	576169	8873	90043381
Thalamus haemorrhage	11.98	10.26	19	576174	734	90051520
Hepatic cancer	11.94	10.26	62	576131	4819	90047435
Post transplant lymphoproliferative disorder	11.93	10.26	16	576177	6933	90045321
Oral pain	11.91	10.26	282	575911	32401	90019853
Exposure via skin contact	11.91	10.26	32	576161	10673	90041581
Acid base balance abnormal	11.87	10.26	13	576180	347	90051907
Medication error	11.86	10.26	655	575538	83997	89968257
White blood cell count increased	11.85	10.26	532	575661	66709	89985545
Mucosal erosion	11.85	10.26	32	576161	1813	90050441
Transferrin saturation decreased	11.84	10.26	21	576172	890	90051364
Blood bicarbonate increased	11.84	10.26	21	576172	890	90051364
Peritoneal dialysis	11.84	10.26	15	576178	469	90051785
Stridor	11.81	10.26	61	576132	4732	90047522
Blood culture negative	11.81	10.26	10	576183	192	90052062
Vertigo	11.80	10.26	550	575643	69261	89982993
Urinary tract infection enterococcal	11.72	10.26	44	576149	2972	90049282
Aortic aneurysm rupture	11.72	10.26	16	576177	539	90051715
Drug level above therapeutic	11.69	10.26	70	576123	5739	90046515
Irritability	11.67	10.26	158	576035	35504	90016750
Multiple injuries	11.63	10.26	32	576161	1833	90050421
Glucose urine present	11.63	10.26	21	576172	903	90051351
Diarrhoea infectious	11.61	10.26	25	576168	1224	90051030
Thyroxine free decreased	11.61	10.26	20	576173	828	90051426
Renin increased	11.60	10.26	10	576183	197	90052057
Shunt occlusion	11.57	10.26	19	576174	756	90051498
Second primary malignancy	11.57	10.26	31	576162	10347	90041907
Oesophageal haemorrhage	11.56	10.26	16	576177	546	90051708
Fear of eating	11.55	10.26	14	576179	418	90051836
Sinus pain	11.53	10.26	66	576127	5323	90046931
Cryptogenic cirrhosis	11.52	10.26	5	576188	25	90052229
Optic neuritis	11.49	10.26	28	576165	9650	90042604
Musculoskeletal disorder	11.48	10.26	86	576107	21683	90030571
Intra-abdominal fluid collection	11.48	10.26	42	576151	2802	90049452
Tremor	11.48	10.26	1127	575066	152046	89900208
Retinopathy of prematurity	11.46	10.26	13	576180	361	90051893
Brain herniation	11.45	10.26	55	576138	4145	90048109
Epidermolysis	11.43	10.26	18	576175	691	90051563
Electrocardiogram QRS complex prolonged	11.42	10.26	83	576110	7265	90044989
Viral sepsis	11.41	10.26	6	576187	49	90052205
Pneumonia respiratory syncytial viral	11.39	10.26	26	576167	1325	90050929
Skin induration	11.38	10.26	46	576147	3216	90049038
Argon plasma coagulation	11.37	10.26	5	576188	26	90052228
Heavy menstrual bleeding	11.36	10.26	80	576113	20450	90031804
Anticoagulation drug level increased	11.36	10.26	12	576181	307	90051947
Catheter site scab	11.36	10.26	11	576182	253	90052001
Haemophagocytic lymphohistiocytosis	11.36	10.26	55	576138	15404	90036850
Infusion site infection	11.35	10.26	40	576153	2620	90049634
Electrocardiogram T wave inversion	11.35	10.26	50	576143	3633	90048621
Tonsillar haemorrhage	11.32	10.26	11	576182	254	90052000
Atrial tachycardia	11.31	10.26	71	576122	5919	90046335
Joint effusion	11.31	10.26	76	576117	19634	90032620
Splenic injury	11.31	10.26	10	576183	204	90052050
Ammonia abnormal	11.29	10.26	11	576182	255	90051999
Bradypnoea	11.28	10.26	59	576134	4599	90047655
Gastrointestinal arteriovenous malformation	11.28	10.26	16	576177	559	90051695
Sodium retention	11.25	10.26	9	576184	159	90052095
Hypertransaminasaemia	11.23	10.26	57	576136	15768	90036486
Cardiac resynchronisation therapy	11.21	10.26	5	576188	27	90052227
Idiopathic pulmonary fibrosis	11.21	10.26	29	576164	1601	90050653
Carotid artery stenosis	11.20	10.26	65	576128	5269	90046985
Vessel puncture site haemorrhage	11.15	10.26	8	576185	119	90052135
Obstructive defaecation	11.15	10.26	11	576182	259	90051995
Intestinal polyp	11.11	10.26	28	576165	1521	90050733
Band neutrophil count decreased	11.10	10.26	8	576185	120	90052134
Metastases to bone	11.10	10.26	106	576087	25399	90026855
Somatic symptom disorder	11.08	10.26	4	576189	3437	90048817
Electrocardiogram U-wave abnormality	11.07	10.26	5	576188	28	90052226
Multiple allergies	11.06	10.26	146	576047	15000	90037254
Heart valve replacement	11.06	10.26	19	576174	785	90051469
Allergy to chemicals	11.05	10.26	5	576188	3749	90048505
Implantable defibrillator insertion	11.04	10.26	16	576177	570	90051684
Peritonitis lupus	11.04	10.26	4	576189	11	90052243
Femoral pulse decreased	11.04	10.26	4	576189	11	90052243
Skin plaque	10.96	10.26	30	576163	9945	90042309
Accelerated idioventricular rhythm	10.96	10.26	7	576186	85	90052169
Enuresis	10.94	10.26	4	576189	3410	90048844
Bifascicular block	10.93	10.26	8	576185	123	90052131
Tongue haematoma	10.93	10.26	8	576185	123	90052131
Cervical dysplasia	10.93	10.26	6	576187	4028	90048226
Biliary dilatation	10.91	10.26	40	576153	2671	90049583
Respiratory disorder	10.91	10.26	321	575872	64495	89987759
Monoclonal immunoglobulin present	10.90	10.26	34	576159	2090	90050164
Supraventricular tachyarrhythmia	10.89	10.26	7	576186	86	90052168
Cardiac ventricular thrombosis	10.89	10.26	23	576170	1111	90051143
Cushingoid	10.88	10.26	32	576161	10363	90041891
Cor pulmonale chronic	10.88	10.26	11	576182	267	90051987
Restrictive cardiomyopathy	10.88	10.26	12	576181	323	90051931
Right ventricular hypertrophy	10.84	10.26	19	576174	798	90051456
Acute cutaneous lupus erythematosus	10.82	10.26	12	576181	325	90051929
Anal fistula	10.81	10.26	7	576186	4294	90047960
Influenza like illness	10.80	10.26	411	575782	80200	89972054
Respiratory syncytial virus test positive	10.80	10.26	22	576171	1036	90051218
Peripheral sensory neuropathy	10.79	10.26	27	576166	9223	90043031
PO2 abnormal	10.79	10.26	4	576189	12	90052242
Diverticulum intestinal haemorrhagic	10.77	10.26	30	576163	1731	90050523
Cranial nerve palsies multiple	10.76	10.26	7	576186	88	90052166
Endarterectomy	10.73	10.26	10	576183	219	90052035
Erythropenia	10.73	10.26	10	576183	219	90052035
Sensory loss	10.72	10.26	69	576124	18006	90034248
Oesophageal ulcer haemorrhage	10.70	10.26	14	576179	452	90051802
Walking disability	10.69	10.26	27	576166	1468	90050786
Drug dependence	10.68	10.26	253	575940	29074	90023180
Anticoagulation drug level abnormal	10.66	10.26	8	576185	128	90052126
Blood electrolytes decreased	10.64	10.26	27	576166	1473	90050781
Flail chest	10.62	10.26	7	576186	90	90052164
Stoma site dermatitis	10.62	10.26	11	576182	275	90051979
Cell death	10.60	10.26	43	576150	3012	90049242
Ammonia decreased	10.55	10.26	4	576189	13	90052241
Traumatic intracranial haemorrhage	10.54	10.26	17	576176	666	90051588
Biopsy kidney abnormal	10.52	10.26	5	576188	32	90052222
Regurgitation	10.50	10.26	34	576159	2132	90050122
Enzyme abnormality	10.49	10.26	9	576184	176	90052078
Skin discolouration	10.48	10.26	362	575831	43953	90008301
Dizziness	10.46	10.26	4029	572164	585255	89466999
Cerebral ischaemia	10.46	10.26	80	576113	7116	90045138
Subchorionic haematoma	10.46	10.26	8	576185	132	90052122
Loss of employment	10.46	10.26	3	576190	2984	90049270
Anaemia folate deficiency	10.42	10.26	15	576178	531	90051723
Intraventricular haemorrhage	10.42	10.26	37	576156	2432	90049822
Injection site induration	10.41	10.26	33	576160	10435	90041819
Cholangitis acute	10.40	10.26	16	576177	602	90051652
Muscle necrosis	10.39	10.26	19	576174	825	90051429
Intracardiac thrombus	10.39	10.26	36	576157	2338	90049916
Ventricular enlargement	10.38	10.26	6	576187	60	90052194
Neuroleptic malignant syndrome	10.36	10.26	55	576138	15041	90037213
Protein urine present	10.35	10.26	78	576115	6906	90045348
Exfoliative rash	10.35	10.26	44	576149	3148	90049106
Dysstasia	10.34	10.26	220	575973	24832	90027422
Hyporesponsive to stimuli	10.34	10.26	28	576165	1589	90050665
Failure to thrive	10.33	10.26	90	576103	8321	90043933
Rectal ulcer haemorrhage	10.33	10.26	10	576183	230	90052024
Culture positive	10.31	10.26	14	576179	469	90051785
Paroxysmal arrhythmia	10.30	10.26	6	576187	61	90052193
Electrocardiogram ST segment depression	10.30	10.26	45	576148	3258	90048996
Skin tightness	10.29	10.26	56	576137	4432	90047822
Premature delivery	10.29	10.26	321	575872	38441	90013813

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	2355.52	11.76	8734	432795	358603	41821203
Cardiac failure congestive	2179.12	11.76	3485	438044	82117	42097689
Cardiac failure	1559.96	11.76	3428	438101	103428	42076378
Drug ineffective	1235.35	11.76	2968	438561	627229	41552577
Hyperkalaemia	1186.93	11.76	2593	438936	77865	42101941
Off label use	818.22	11.76	3626	437903	634709	41545097
Hypotension	710.50	11.76	4832	436697	252799	41927007
Oedema peripheral	651.23	11.76	2964	438565	133112	42046694
Renal failure	623.08	11.76	3042	438487	140684	42039122
Drug abuse	566.91	11.76	189	441340	104582	42075224
International normalised ratio increased	541.11	11.76	1397	440132	46771	42133035
Dyspnoea	520.40	11.76	6922	434607	435699	41744107
Atrial fibrillation	475.93	11.76	2766	438763	136827	42042979
Cardiac failure chronic	436.47	11.76	518	441011	9083	42170723
Blood creatinine increased	411.42	11.76	2235	439294	107768	42072038
Blood urea increased	387.88	11.76	970	440559	31823	42147983
Hypokalaemia	362.73	11.76	1589	439940	70132	42109674
Toxicity to various agents	361.53	11.76	1193	440336	227943	41951863
Renal impairment	356.71	11.76	2155	439374	108073	42071733
Oedema	340.61	11.76	1249	440280	50752	42129054
Fluid retention	330.54	11.76	893	440636	30726	42149080
Product use in unapproved indication	309.35	11.76	934	440595	183522	41996284
Pulmonary hypertension	295.50	11.76	713	440816	22856	42156950
Hepatic encephalopathy	275.83	11.76	559	440970	15883	42163923
Chronic kidney disease	273.45	11.76	1091	440438	46150	42133656
Completed suicide	271.21	11.76	361	441168	96104	42083702
Melaena	253.15	11.76	930	440599	37816	42141990
Intentional product misuse	245.80	11.76	170	441359	61730	42118076
Dehydration	244.43	11.76	2392	439137	139375	42040431
Bradycardia	239.77	11.76	1612	439917	83872	42095934
Hypervolaemia	229.63	11.76	641	440888	22484	42157322
Myocardial infarction	226.91	11.76	2119	439410	121890	42057916
Treatment failure	224.43	11.76	191	441338	62433	42117373
Orthostatic hypotension	216.12	11.76	753	440776	29817	42149989
Arthralgia	211.46	11.76	1253	440276	203985	41975821
Suicide attempt	210.66	11.76	107	441422	45993	42133813
Gastrointestinal haemorrhage	208.86	11.76	1728	439801	95998	42083808
Suicidal ideation	206.66	11.76	121	441408	48040	42131766
Ventricular tachycardia	205.55	11.76	734	440795	29426	42150380
Anaemia	205.20	11.76	4057	437472	276221	41903585
Hyponatraemia	204.65	11.76	1771	439758	99691	42080115
Product dose omission issue	204.44	11.76	863	440666	153502	42026304
Syncope	203.05	11.76	1740	439789	97666	42082140
Pleural effusion	201.21	11.76	1706	439823	95460	42084346
Fall	196.62	11.76	3467	438062	231053	41948753
Ejection fraction decreased	195.94	11.76	588	440941	21499	42158307
Febrile neutropenia	195.93	11.76	1125	440404	184578	41995228
Hypoglycaemia	195.21	11.76	1173	440356	58681	42121125
Neutropenia	193.23	11.76	1241	440288	198190	41981616
Injection site pain	193.16	11.76	188	441341	57610	42122196
Pulmonary oedema	192.62	11.76	1073	440456	52199	42127607
Intentional overdose	186.76	11.76	155	441374	51301	42128505
Foetal exposure during pregnancy	181.19	11.76	135	441394	47176	42132630
Drug interaction	176.69	11.76	3808	437721	263191	41916615
N-terminal prohormone brain natriuretic peptide increased	173.19	11.76	196	441333	3257	42176549
Cardiac failure acute	170.42	11.76	412	441117	13221	42166585
Headache	167.91	11.76	1627	439902	237742	41942064
Mitral valve incompetence	161.68	11.76	455	441074	16034	42163772
Lactic acidosis	161.20	11.76	908	440621	44353	42135453
Drug dependence	156.34	11.76	53	441476	29041	42150765
Pulmonary arterial hypertension	154.11	11.76	332	441197	9855	42169951
Rheumatoid arthritis	152.58	11.76	129	441400	42311	42137495
Drug intolerance	151.94	11.76	384	441145	80040	42099766
Orthopnoea	150.60	11.76	230	441299	5187	42174619
Dyspnoea exertional	149.22	11.76	960	440569	49188	42130618
Hypovolaemia	147.77	11.76	351	441178	11134	42168672
Drug hypersensitivity	146.61	11.76	532	440997	98857	42080949
Drug ineffective for unapproved indication	139.89	11.76	163	441366	46000	42133806
Right ventricular failure	139.52	11.76	307	441222	9248	42170558
Rectal haemorrhage	137.53	11.76	933	440596	48673	42131133
Generalised oedema	136.70	11.76	409	441120	14927	42164879
Sedation	135.87	11.76	73	441456	30402	42149404
Musculoskeletal stiffness	134.76	11.76	245	441284	57520	42122286
Intentional product use issue	131.83	11.76	348	441181	71485	42108321
Therapeutic product effect incomplete	129.94	11.76	344	441185	70595	42109211
Blood potassium increased	128.76	11.76	454	441075	18082	42161724
Appendicitis	128.69	11.76	28	441501	20585	42159221
Ascites	124.12	11.76	1008	440521	55670	42124136
Tricuspid valve incompetence	123.34	11.76	321	441208	10792	42169014
COVID-19	121.85	11.76	703	440826	115245	42064561
Coronary artery disease	121.78	11.76	963	440566	52757	42127049
Pyrexia	121.59	11.76	3131	438398	390911	41788895
Psychotic disorder	117.55	11.76	79	441450	29129	42150677
Respiratory failure	115.75	11.76	1918	439611	126214	42053592
Ischaemic cardiomyopathy	115.69	11.76	227	441302	6295	42173511
Nausea	115.32	11.76	3180	438349	393619	41786187
Myelosuppression	115.09	11.76	150	441379	40311	42139495
Therapeutic product effect decreased	112.54	11.76	144	441385	39006	42140800
Blood pressure decreased	111.73	11.76	1007	440522	57325	42122481
Sinusitis	111.73	11.76	199	441330	47093	42132713
Inappropriate schedule of product administration	109.81	11.76	565	440964	95337	42084469
Congestive cardiomyopathy	107.55	11.76	263	441266	8501	42171305
Cardiomegaly	107.43	11.76	400	441129	16366	42163440
Pain	107.34	11.76	1837	439692	243011	41936795
Acute myocardial infarction	107.29	11.76	996	440533	57169	42122637
Hepatic failure	105.84	11.76	717	440812	37383	42142423
Infusion related reaction	105.28	11.76	303	441226	60503	42119303
Nasopharyngitis	103	11.76	483	441046	83513	42096293
Urticaria	100.96	11.76	409	441120	73627	42106179
Metabolic alkalosis	99.88	11.76	116	441413	1985	42177821
Rash	99.63	11.76	2149	439380	274805	41905001
Acute pulmonary oedema	99.22	11.76	253	441276	8398	42171408
Psoriatic arthropathy	98.51	11.76	69	441460	24898	42154908
Synovitis	97.48	11.76	21	441508	15546	42164260
Rhabdomyolysis	97.05	11.76	1235	440294	76784	42103022
Product use issue	96.68	11.76	437	441092	76314	42103492
Asthenia	96.33	11.76	3686	437843	277107	41902699
Anuria	95.73	11.76	300	441229	11232	42168574
Gravitational oedema	95.25	11.76	70	441459	638	42179168
Seizure	94.16	11.76	797	440732	119764	42060042
BRASH syndrome	93.94	11.76	105	441424	1720	42178086
Drug use disorder	93.33	11.76	3	441526	10330	42169476
Myocardial ischaemia	91.57	11.76	396	441133	17366	42162440
Hypernatraemia	90.79	11.76	269	441260	9763	42170043
Aggression	88.81	11.76	204	441325	43959	42135847
Incorrect route of product administration	88.44	11.76	73	441456	24232	42155574
Urine output decreased	87.64	11.76	280	441249	10593	42169213
Brain natriuretic peptide increased	87.20	11.76	207	441322	6563	42173243
Rales	85.98	11.76	287	441242	11113	42168693
No adverse event	85.32	11.76	172	441357	38849	42140957
Shock haemorrhagic	84.42	11.76	363	441166	15879	42163927
Therapy partial responder	83.49	11.76	52	441477	19969	42159837
Cardiac arrest	83.27	11.76	1593	439936	107727	42072079
Renal injury	82.91	11.76	298	441231	11982	42167824
Prostate cancer	82.86	11.76	215	441314	44428	42135378
Hypersensitivity	82.47	11.76	427	441102	71943	42107863
Glomerular filtration rate decreased	79.34	11.76	358	441171	15993	42163813
Venous pressure jugular increased	79.19	11.76	65	441464	707	42179099
Presyncope	78.94	11.76	448	441081	21939	42157867
Pemphigoid	78.90	11.76	280	441249	11187	42168619
Accidental exposure to product	78.31	11.76	58	441471	20335	42159471
Haemoglobin decreased	76.95	11.76	1856	439673	130615	42049191
Akathisia	76.89	11.76	9	441520	10442	42169364
Drug withdrawal syndrome	76.84	11.76	66	441463	21483	42158323
Immune reconstitution inflammatory syndrome	76.48	11.76	8	441521	10135	42169671
Left ventricular dysfunction	75.87	11.76	277	441252	11224	42168582
Haematoma	75.82	11.76	524	441005	27499	42152307
Mucosal inflammation	75.63	11.76	260	441269	49114	42130692
Left ventricular failure	75.09	11.76	182	441347	5849	42173957
Infection	74.55	11.76	771	440758	111297	42068509
Coronary artery bypass	74.18	11.76	158	441371	4652	42175154
Cardiomyopathy	74.16	11.76	394	441135	18816	42160990
Injection site reaction	74.06	11.76	35	441494	15686	42164120
Multiple sclerosis relapse	73.21	11.76	28	441501	14236	42165570
Neuropathy peripheral	73.07	11.76	688	440841	101165	42078641
Eosinophilia	73.03	11.76	587	440942	32312	42147494
Hepatic cirrhosis	72.61	11.76	399	441130	19303	42160503
Poisoning	71.95	11.76	31	441498	14668	42165138
Sopor	71.67	11.76	299	441230	12903	42166903
Myasthenia gravis	71.43	11.76	39	441490	16098	42163708
Chronic obstructive pulmonary disease	71.38	11.76	982	440547	62132	42117674
Gastrointestinal disorder	71.24	11.76	246	441283	46407	42133399
Injury	71.21	11.76	435	441094	21881	42157925
Anaphylactic reaction	70.37	11.76	218	441311	42525	42137281
Cytomegalovirus infection reactivation	70.15	11.76	15	441514	11163	42168643
Malignant neoplasm progression	69.57	11.76	752	440777	107648	42072158
Fear	68.92	11.76	260	441269	10705	42169101
Cardioactive drug level increased	68.10	11.76	87	441442	1650	42178156
Arthropathy	67.71	11.76	127	441402	29470	42150336
Colitis	67.50	11.76	251	441278	46321	42133485
Cardiac disorder	66.64	11.76	788	440741	48144	42131662
Hypocalcaemia	66.23	11.76	537	440992	29636	42150170
Sleep disorder	65.99	11.76	265	441264	47830	42131976
Cytokine release syndrome	65.84	11.76	238	441291	44289	42135517
Injection site swelling	65.53	11.76	48	441481	16925	42162881
Oliguria	65.45	11.76	229	441300	9084	42170722
Insomnia	64.89	11.76	849	440680	117404	42062402
Jugular vein distension	64.80	11.76	55	441474	629	42179177
Haematotoxicity	64.49	11.76	17	441512	10968	42168838
Cardiac amyloidosis	64.21	11.76	91	441438	1914	42177892
Irritability	64.08	11.76	121	441408	28007	42151799
Pruritus	63.71	11.76	1479	440050	187292	41992514
Azotaemia	63.22	11.76	169	441360	5775	42174031
Epistaxis	63.14	11.76	1008	440521	65818	42113988
Pathogen resistance	63.02	11.76	20	441509	11430	42168376
Atrioventricular block	62.94	11.76	231	441298	9384	42170422
Schizophrenia	62.56	11.76	16	441513	10534	42169272
Vomiting	62.03	11.76	2414	439115	287309	41892497
Diastolic dysfunction	62.01	11.76	186	441343	6797	42173009
Drug resistance	61.99	11.76	167	441362	34081	42145725
Nephrolithiasis	61.95	11.76	186	441343	36644	42143162
Injection site erythema	61.50	11.76	71	441458	20124	42159682
Hallucination, auditory	61.44	11.76	39	441490	14825	42164981
Syringe issue	61.40	11.76	8	441521	8548	42171258
Intentional self-injury	61.32	11.76	41	441488	15161	42164645
Bundle branch block left	60.85	11.76	176	441353	6300	42173506
Intercepted product preparation error	60.75	11.76	4	441525	7385	42172421
Arrhythmia	60.65	11.76	662	440867	39655	42140151
Cardiorenal syndrome	59.57	11.76	59	441470	834	42178972
Serotonin syndrome	59.03	11.76	111	441418	25734	42154072
Neoplasm progression	58.27	11.76	134	441395	28866	42150940
Therapeutic response shortened	58.20	11.76	34	441495	13520	42166286
Anhedonia	58.20	11.76	193	441336	7447	42172359
Vitamin B1 deficiency	57.76	11.76	42	441487	376	42179430
Erythema	57.54	11.76	787	440742	108006	42071800
Product storage error	56.95	11.76	22	441507	11118	42168688
Neutrophil count decreased	56.60	11.76	404	441125	63011	42116795
Joint swelling	56.12	11.76	443	441086	67579	42112227
Exposure during pregnancy	54.62	11.76	11	441518	8537	42171269
Hypoglycaemic coma	54.22	11.76	100	441429	2644	42177162
Hepatorenal syndrome	53.88	11.76	102	441427	2752	42177054
Substance abuse	53.78	11.76	13	441516	8892	42170914
Hypoxia	52.79	11.76	1016	440513	68770	42111036
Respiratory depression	52.58	11.76	71	441458	18797	42161009
Torsade de pointes	52.54	11.76	202	441327	8392	42171414
Atrial flutter	52.37	11.76	332	441197	16919	42162887
Upper gastrointestinal haemorrhage	51.97	11.76	511	441018	29788	42150018
Concomitant disease progression	51.72	11.76	93	441436	2410	42177396
Haematuria	51.68	11.76	864	440665	56935	42122871
Concomitant disease aggravated	51.63	11.76	168	441361	6418	42173388
Cytomegalovirus infection	51.61	11.76	167	441362	32139	42147667
Uveitis	51.26	11.76	16	441513	9242	42170564
Disease progression	51.15	11.76	1116	440413	142540	42037266
Dyspnoea paroxysmal nocturnal	51.11	11.76	73	441456	1547	42178259
Gout	51.00	11.76	479	441050	27576	42152230
Depression	50.81	11.76	829	440700	110534	42069272
Blood creatine increased	50.78	11.76	152	441377	5548	42174258
Hyperuricaemia	50.03	11.76	212	441317	9212	42170594
Paraesthesia	49.39	11.76	504	441025	72955	42106851
Device interaction	49.23	11.76	44	441485	542	42179264
Dry mouth	49.05	11.76	229	441300	39650	42140156
Overdose	48.89	11.76	781	440748	104483	42075323
Lymphadenopathy	48.89	11.76	179	441350	33186	42146620
Peripheral swelling	48.88	11.76	1253	440276	89017	42090789
Prothrombin time prolonged	48.72	11.76	211	441318	9258	42170548
Post transplant lymphoproliferative disorder	48.33	11.76	17	441512	9103	42170703
Infective pulmonary exacerbation of cystic fibrosis	48.03	11.76	11	441518	7807	42171999
Haemodialysis	47.81	11.76	222	441307	10038	42169768
Multiple-drug resistance	47.67	11.76	9	441520	7313	42172493
Vascular purpura	47.46	11.76	83	441446	2103	42177703
Hyperhidrosis	47.05	11.76	657	440872	89855	42089951
Blood potassium decreased	47.04	11.76	367	441162	20017	42159789
Low cardiac output syndrome	46.98	11.76	45	441484	609	42179197
Erectile dysfunction	46.98	11.76	119	441410	24794	42155012
Hypoaesthesia	46.95	11.76	493	441036	70970	42108836
Dialysis	46.38	11.76	246	441283	11740	42168066
Fatigue	46.32	11.76	3885	437644	431756	41748050
Polyomavirus-associated nephropathy	46.28	11.76	3	441526	5612	42174194
Polyuria	46.20	11.76	216	441313	9795	42170011
Pulmonary congestion	44.86	11.76	298	441231	15432	42164374
Stomatitis	44.73	11.76	321	441208	50008	42129798
Left ventricular dilatation	44.71	11.76	51	441478	855	42178951
Somnolence	44.16	11.76	1118	440411	139987	42039819
Back pain	43.92	11.76	1125	440404	140651	42039155
Gastrointestinal tract mucosal pigmentation	43.81	11.76	41	441488	538	42179268
Generalised tonic-clonic seizure	43.80	11.76	134	441395	26245	42153561
International normalised ratio decreased	43.68	11.76	125	441404	4447	42175359
Aortic valve incompetence	43.44	11.76	158	441371	6390	42173416
Chills	42.98	11.76	700	440829	93366	42086440
Ventricular extrasystoles	42.71	11.76	261	441268	13129	42166677
Acute graft versus host disease	42.37	11.76	16	441513	8199	42171607
Alopecia	42.28	11.76	158	441371	29118	42150688
BK virus infection	42.24	11.76	19	441510	8765	42171041
Neuralgia	42.07	11.76	131	441398	25516	42154290
Abdominal pain	42.02	11.76	1581	439948	188890	41990916
Euphoric mood	41.87	11.76	8	441521	6445	42173361
Therapeutic response decreased	41.80	11.76	219	441310	36793	42143013
Drug dose omission by device	41.07	11.76	6	441523	5880	42173926
Angina pectoris	40.99	11.76	521	441008	32375	42147431
Lymphoid tissue hypoplasia	40.94	11.76	48	441481	830	42178976
Neuroleptic malignant syndrome	40.93	11.76	102	441427	21370	42158436
White blood cell count decreased	40.92	11.76	852	440677	109544	42070262
Paranoia	40.91	11.76	51	441478	13975	42165831
Agitation	40.90	11.76	447	441082	63867	42115939
Oesophageal varices haemorrhage	40.86	11.76	105	441424	3502	42176304
Psoriasis	40.80	11.76	315	441214	48289	42131517
Abnormal behaviour	40.70	11.76	139	441390	26312	42153494
Mental disorder	40.68	11.76	78	441451	17951	42161855
Extrapyramidal disorder	40.64	11.76	67	441462	16345	42163461
Device issue	40.59	11.76	48	441481	13461	42166345
Haematemesis	40.52	11.76	485	441044	29714	42150092
Depressed mood	40.11	11.76	117	441412	23267	42156539
Subdural haematoma	40.05	11.76	391	441138	22747	42157059
Thymus hypoplasia	39.99	11.76	47	441482	815	42178991
Haemoptysis	39.77	11.76	686	440843	45481	42134325
Incorrect dose administered	39.63	11.76	354	441175	52620	42127186
Dermatitis atopic	39.54	11.76	42	441487	12362	42167444
Pericardial haemorrhage	39.51	11.76	103	441426	3466	42176340
Cardiac murmur	39.49	11.76	247	441282	12528	42167278
Ankylosing spondylitis	39.42	11.76	12	441517	7044	42172762
Toxic epidermal necrolysis	39.20	11.76	437	441092	26313	42153493
Pneumonia	39.14	11.76	4968	436561	417181	41762625
Acute graft versus host disease in skin	39.06	11.76	14	441515	7410	42172396
Iron deficiency anaemia	39.00	11.76	250	441279	12789	42167017
Withdrawal syndrome	38.79	11.76	58	441471	14717	42165089
Memory impairment	38.72	11.76	333	441196	49889	42129917
C-reactive protein abnormal	38.69	11.76	24	441505	9237	42170569
Haemophagocytic lymphohistiocytosis	38.41	11.76	82	441447	18140	42161666
Illness	38.36	11.76	131	441398	24799	42155007
Dizziness	38.30	11.76	3038	438491	246216	41933590
Diabetic ketoacidosis	38.30	11.76	112	441417	22255	42157551
Normochromic normocytic anaemia	38.18	11.76	190	441339	8841	42170965
Vision blurred	37.95	11.76	364	441165	53335	42126471
Acute respiratory failure	37.77	11.76	589	440940	38269	42141537
Blood cholesterol increased	37.53	11.76	146	441383	26595	42153211
Left ventricular hypertrophy	37.25	11.76	193	441336	9126	42170680
Hypomagnesaemia	37.13	11.76	455	441074	28033	42151773
Purpura	36.92	11.76	230	441299	11649	42168157
Hepatotoxicity	36.88	11.76	135	441394	25032	42154774
Right ventricular dysfunction	36.62	11.76	58	441471	1351	42178455
Exercise tolerance decreased	36.61	11.76	142	441387	5924	42173882
Nephrotic syndrome	36.56	11.76	183	441346	8535	42171271
Cerebrovascular accident	36.47	11.76	1289	440240	95871	42083935
Diverticulitis	36.18	11.76	118	441411	22655	42157151
Cardiogenic shock	36.09	11.76	544	440985	35096	42144710
Visual impairment	35.92	11.76	280	441249	42833	42136973
Drug reaction with eosinophilia and systemic symptoms	35.81	11.76	624	440905	41451	42138355
Acrodermatitis enteropathica	35.80	11.76	10	441519	0	42179806
Hepatocellular carcinoma	35.78	11.76	174	441355	8020	42171786
Pericardial effusion	35.77	11.76	462	441067	28813	42150993
Priapism	35.61	11.76	11	441518	6396	42173410
Tremor	35.35	11.76	750	440779	96179	42083627
Emotional distress	35.09	11.76	286	441243	15807	42163999
Night sweats	34.92	11.76	99	441430	19870	42159936
Dermatitis exfoliative generalised	34.88	11.76	136	441393	5688	42174118
Device leakage	34.87	11.76	33	441496	10252	42169554
Dyspnoea at rest	34.77	11.76	110	441419	4139	42175667
Dystonia	34.76	11.76	49	441480	12741	42167065
Left ventricular enlargement	34.73	11.76	43	441486	789	42179017
Cerebral hypoperfusion	34.38	11.76	48	441481	995	42178811
Sudden cardiac death	34.35	11.76	104	441425	3820	42175986
Anger	34.27	11.76	51	441478	12967	42166839
Dilatation atrial	34.18	11.76	72	441457	2103	42177703
Enteritis	34.06	11.76	37	441492	10779	42169027
Cutaneous vasculitis	33.88	11.76	151	441378	6709	42173097
Salivary hypersecretion	33.84	11.76	38	441491	10905	42168901
Eye pruritus	33.81	11.76	41	441488	11371	42168435
Blood loss anaemia	33.77	11.76	194	441335	9542	42170264
Sexual dysfunction	33.62	11.76	14	441515	6761	42173045
Cardiac output decreased	33.61	11.76	48	441481	1017	42178789
Metabolic acidosis	33.61	11.76	738	440791	51120	42128686
Panic attack	33.45	11.76	39	441490	11006	42168800
Muscle spasms	33.39	11.76	659	440870	85385	42094421
Sudden death	33.33	11.76	290	441239	16339	42163467
Angina unstable	33.32	11.76	218	441311	11230	42168576
Left atrial enlargement	33.18	11.76	47	441482	988	42178818
Medication error	33.16	11.76	505	441024	32649	42147157
Epstein-Barr virus infection	33.16	11.76	31	441498	9687	42170119
Blood lactic acid	33.14	11.76	28	441501	318	42179488
Hypophosphataemia	32.95	11.76	109	441420	20836	42158970
Progressive multifocal leukoencephalopathy	32.56	11.76	43	441486	11493	42168313
Cerebral haemorrhage	32.48	11.76	576	440953	38390	42141416
Hypocoagulable state	32.48	11.76	46	441483	967	42178839
Drug effective for unapproved indication	32.44	11.76	14	441515	6619	42173187
Ear infection	31.96	11.76	52	441477	12752	42167054
Congestive hepatopathy	31.95	11.76	74	441455	2308	42177498
Head injury	31.89	11.76	340	441189	20242	42159564
Creatinine renal clearance decreased	31.86	11.76	96	441433	3517	42176289
Graft versus host disease	31.78	11.76	53	441476	12872	42166934
Confusional state	31.77	11.76	2078	439451	165519	42014287
Atrioventricular block complete	31.63	11.76	214	441315	11150	42168656
Candida infection	31.61	11.76	116	441413	21494	42158312
Hepatic cancer	31.42	11.76	172	441357	8308	42171498
Hepatitis B reactivation	31.18	11.76	5	441524	4573	42175233
Muscle twitching	31.16	11.76	46	441483	11734	42168072
Aspergillus infection	31.15	11.76	74	441455	15763	42164043
Cellulitis	31.06	11.76	847	440682	60738	42119068
Peritonitis bacterial	31.04	11.76	148	441381	6767	42173039
Hypogammaglobulinaemia	30.90	11.76	47	441482	11844	42167962
Dry eye	30.86	11.76	72	441457	15434	42164372
Hypercreatinaemia	30.78	11.76	24	441505	241	42179565
Anaphylactic shock	30.74	11.76	132	441397	23385	42156421
Systemic infection	30.66	11.76	8	441521	5197	42174609
Electrocardiogram QT prolonged	30.65	11.76	681	440848	47264	42132542
Mucormycosis	30.56	11.76	18	441511	7125	42172681
Poisoning deliberate	30.46	11.76	36	441493	10098	42169708
Unevaluable event	30.44	11.76	512	441017	33776	42146030
Bradyarrhythmia	30.43	11.76	78	441451	2597	42177209
Diplopia	30.42	11.76	108	441421	20208	42159598
Cognitive disorder	30.33	11.76	218	441311	33954	42145852
Drug-induced liver injury	30.30	11.76	252	441277	38021	42141785
Alanine aminotransferase abnormal	30.29	11.76	7	441522	4937	42174869
Gastrointestinal vascular malformation haemorrhagic	30.28	11.76	40	441489	785	42179021
Cor pulmonale	30.17	11.76	40	441489	788	42179018
Neurotoxicity	30.16	11.76	134	441395	23517	42156289
Graft versus host disease in gastrointestinal tract	30.11	11.76	8	441521	5135	42174671
Cardiac valve disease	30.10	11.76	91	441438	3340	42176466
Tenosynovitis	30.08	11.76	6	441523	4689	42175117
Scrotal oedema	30.00	11.76	63	441466	1836	42177970
Pseudoporphyria	29.96	11.76	31	441498	463	42179343
Injection site haemorrhage	29.92	11.76	47	441482	11689	42168117
Pancreatitis	29.85	11.76	295	441234	42973	42136833
Influenza	29.63	11.76	459	441070	61716	42118090
Migraine	29.47	11.76	149	441380	25265	42154541
Influenza like illness	29.30	11.76	201	441328	31639	42148167
Product dose omission in error	29.28	11.76	26	441503	8328	42171478
Transfusion	29.27	11.76	198	441331	10316	42169490
Chronic graft versus host disease	29.02	11.76	13	441516	6012	42173794
Abdominal discomfort	29.00	11.76	577	440952	74678	42105128
Colitis ulcerative	28.93	11.76	156	441373	26019	42153787
Mitral valve thickening	28.89	11.76	30	441499	450	42179356
Exposure to toxic agent	28.89	11.76	8	441521	4996	42174810
Tardive dyskinesia	28.85	11.76	18	441511	6906	42172900
Pulmonary vasculitis	28.77	11.76	135	441394	6131	42173675
Arteriosclerosis	28.73	11.76	299	441230	17690	42162116
Bronchopulmonary aspergillosis	28.62	11.76	104	441425	19325	42160481
Injection site mass	28.51	11.76	28	441501	8547	42171259
Ventricular dysfunction	28.48	11.76	107	441422	4396	42175410
Occult blood positive	28.48	11.76	103	441426	4154	42175652
Tachycardia	28.46	11.76	813	440716	100274	42079532
Ventricular failure	28.45	11.76	17	441512	105	42179701
Cardio-respiratory arrest	28.33	11.76	802	440727	57834	42121972
Blood pressure diastolic abnormal	28.32	11.76	14	441515	6114	42173692
Renal ischaemia	28.27	11.76	57	441472	1613	42178193
Mood altered	28.21	11.76	42	441487	10676	42169130
Anxiety	28.18	11.76	975	440554	117585	42062221
Eye pain	27.92	11.76	87	441442	16943	42162863
Psychiatric decompensation	27.90	11.76	5	441524	4217	42175589
Atrioventricular block first degree	27.75	11.76	137	441392	6354	42173452
Dyskinesia	27.69	11.76	152	441377	25238	42154568
Injection site bruising	27.66	11.76	48	441481	11477	42168329
Ventricular internal diameter abnormal	27.60	11.76	20	441509	178	42179628
Blood phosphorus increased	27.55	11.76	55	441474	12470	42167336
Troponin T increased	27.53	11.76	77	441452	2703	42177103
Drug level decreased	27.34	11.76	38	441491	9939	42169867
Dilatation ventricular	27.33	11.76	73	441456	2493	42177313
Disturbance in attention	27.26	11.76	189	441340	29677	42150129
Blood pressure systolic decreased	27.11	11.76	113	441416	4874	42174932
Disease recurrence	26.99	11.76	188	441341	29490	42150316
Central nervous system lesion	26.98	11.76	25	441504	7845	42171961
Nephrogenic anaemia	26.97	11.76	73	441456	2513	42177293
Blood pressure fluctuation	26.72	11.76	166	441363	26742	42153064
Depressive symptom	26.71	11.76	4	441525	3849	42175957
Hyperparathyroidism secondary	26.68	11.76	59	441470	1783	42178023
Rash maculo-papular	26.66	11.76	541	440988	36962	42142844
Blood creatinine abnormal	26.52	11.76	82	441447	3047	42176759
Ammonia increased	26.46	11.76	107	441422	4552	42175254
Neck pain	26.39	11.76	192	441337	29822	42149984
Asthma	26.10	11.76	471	441058	61843	42117963
Anal fistula	26.09	11.76	16	441513	6197	42173609
Upper respiratory tract infection	26.06	11.76	295	441234	41878	42137928
Inflammatory bowel disease	26.06	11.76	3	441526	3526	42176280
Basal cell carcinoma	25.95	11.76	134	441395	22599	42157207
Small for dates baby	25.92	11.76	11	441518	5252	42174554
Dermatitis exfoliative	25.80	11.76	141	441388	6806	42173000
Renal artery stenosis	25.78	11.76	67	441462	2250	42177556
Prerenal failure	25.70	11.76	69	441460	2364	42177442
Anal abscess	25.68	11.76	26	441503	7824	42171982
Hyperthyroidism	25.64	11.76	244	441285	14097	42165709
Graft versus host disease in skin	25.49	11.76	11	441518	5201	42174605
Amnesia	25.44	11.76	181	441348	28256	42151550
Blood pressure increased	25.44	11.76	833	440696	101095	42078711
Varices oesophageal	25.39	11.76	101	441428	4264	42175542
Bronchopulmonary aspergillosis allergic	25.36	11.76	8	441521	4590	42175216
Arthritis	25.31	11.76	296	441233	41769	42138037
Lipodystrophy acquired	25.31	11.76	3	441526	3447	42176359
Oropharyngeal pain	25.24	11.76	300	441229	42210	42137596
Dry skin	25.06	11.76	351	441178	47987	42131819
Vascular graft	25.03	11.76	52	441477	1504	42178302
Glomerular filtration rate abnormal	24.79	11.76	45	441484	1175	42178631
Hypersensitivity vasculitis	24.75	11.76	82	441447	3162	42176644
Lower gastrointestinal haemorrhage	24.61	11.76	194	441335	10614	42169192
Hyperphosphataemia	24.61	11.76	62	441467	12942	42166864
Nephrogenic systemic fibrosis	24.52	11.76	86	441443	3415	42176391
Ventricular arrhythmia	24.38	11.76	129	441400	6150	42173656
Chronic hepatic failure	24.30	11.76	32	441497	626	42179180
Hydrothorax	24.26	11.76	31	441498	588	42179218
Hypoalbuminaemia	24.25	11.76	258	441271	15352	42164454
Blood bilirubin increased	24.19	11.76	591	440938	41661	42138145
Total lung capacity decreased	24.09	11.76	4	441525	3566	42176240
Dysmorphism	24.04	11.76	3	441526	3313	42176493
Drug specific antibody present	23.90	11.76	6	441523	4000	42175806
Mood swings	23.80	11.76	34	441495	8792	42171014
Intraocular pressure increased	23.80	11.76	19	441510	6414	42173392
Neutropenic sepsis	23.72	11.76	85	441444	15861	42163945
Epilepsy	23.70	11.76	166	441363	26005	42153801
Injection site pruritus	23.66	11.76	38	441491	9367	42170439
Obsessive-compulsive disorder	23.62	11.76	21	441508	6722	42173084
Gastritis erosive	23.49	11.76	131	441398	6372	42173434
Post procedural haematoma	23.48	11.76	52	441477	1573	42178233
Aortic valve stenosis	23.46	11.76	77	441452	2955	42176851
Leukopenia	23.42	11.76	592	440937	74154	42105652
Crepitations	23.36	11.76	83	441446	3318	42176488
Increased appetite	23.34	11.76	35	441494	8871	42170935
Mitral valve calcification	23.33	11.76	31	441498	612	42179194
Neuromyopathy	23.26	11.76	42	441487	1092	42178714
Feeling hot	23.25	11.76	145	441384	23337	42156469
Ischaemic stroke	23.15	11.76	341	441188	21892	42157914
Emotional disorder	22.92	11.76	19	441510	6295	42173511
Hyponatraemic syndrome	22.91	11.76	18	441511	183	42179623
Ejection fraction abnormal	22.88	11.76	45	441484	1250	42178556
Second primary malignancy	22.87	11.76	40	441489	9535	42170271
Ecchymosis	22.79	11.76	148	441381	7604	42172202
Haemoconcentration	22.72	11.76	11	441518	41	42179765
Hypoperfusion	22.65	11.76	47	441482	1358	42178448
Gastric ulcer	22.65	11.76	289	441240	17973	42161833
Mania	22.62	11.76	47	441482	10500	42169306
Ocular hyperaemia	22.50	11.76	87	441442	15876	42163930
Cardiac tamponade	22.48	11.76	130	441399	6410	42173396
Polyneuropathy	22.45	11.76	108	441421	18553	42161253
Micturition urgency	22.30	11.76	57	441472	11841	42167965
International normalised ratio abnormal	22.20	11.76	82	441447	3341	42176465
Aortic stenosis	22.18	11.76	161	441368	8584	42171222
Photophobia	22.17	11.76	31	441498	8088	42171718
Hypercreatininaemia	22.00	11.76	28	441501	529	42179277
Nightmare	21.99	11.76	160	441369	24852	42154954
Coma hepatic	21.97	11.76	25	441504	418	42179388
Bradypnoea	21.92	11.76	9	441520	4384	42175422
Viral mutation identified	21.89	11.76	4	441525	3327	42176479
Faeces discoloured	21.85	11.76	271	441258	16743	42163063
Ventricular hypokinesia	21.84	11.76	134	441395	6750	42173056
Fistula	21.81	11.76	30	441499	7882	42171924
Anticoagulation drug level increased	21.81	11.76	29	441500	573	42179233
Atrial enlargement	21.76	11.76	32	441497	697	42179109
Surgery	21.75	11.76	101	441428	17515	42162291
Microcytic anaemia	21.65	11.76	75	441454	2960	42176846
Knee arthroplasty	21.60	11.76	36	441493	8745	42171061
Mental impairment	21.58	11.76	61	441468	12256	42167550
Coronary arterial stent insertion	21.43	11.76	90	441439	3895	42175911
Plasma cell myeloma	21.40	11.76	645	440884	46933	42132873
Lung disorder	21.38	11.76	649	440880	47274	42132532
Herpes zoster	21.34	11.76	279	441250	38598	42141208
Disseminated aspergillosis	21.32	11.76	52	441477	1678	42178128
Muscle haemorrhage	21.28	11.76	92	441437	4033	42175773
Diffuse large B-cell lymphoma	21.24	11.76	41	441488	9413	42170393
Dizziness postural	21.22	11.76	146	441383	7649	42172157
Peripheral vascular disorder	21.17	11.76	110	441419	5207	42174599
Abscess	21.16	11.76	76	441453	14172	42165634
Hypovolaemic shock	21.15	11.76	158	441371	8501	42171305
Disinhibition	21.09	11.76	7	441522	3888	42175918
Skin toxicity	21.07	11.76	22	441507	6527	42173279
Flushing	20.97	11.76	264	441265	36764	42143042
Tinnitus	20.93	11.76	195	441334	28743	42151063
Facial pain	20.82	11.76	9	441520	4251	42175555
Multiple sclerosis	20.76	11.76	29	441500	7569	42172237
Antipsychotic drug level below therapeutic	20.73	11.76	4	441525	3200	42176606
Blood sodium decreased	20.69	11.76	283	441246	17879	42161927
Device use error	20.67	11.76	4	441525	3193	42176613
Viral infection	20.65	11.76	142	441387	22341	42157465
Eye irritation	20.62	11.76	55	441474	11263	42168543
Posthaemorrhagic hydrocephalus	20.52	11.76	14	441515	112	42179694
Tachyarrhythmia	20.52	11.76	88	441441	3844	42175962
Respiratory distress	20.47	11.76	573	440956	41247	42138559
Prohormone brain natriuretic peptide increased	20.45	11.76	13	441516	91	42179715
Diabetic nephropathy	20.45	11.76	62	441467	2279	42177527
Blood test abnormal	20.41	11.76	67	441462	12839	42166967
Left atrial dilatation	20.41	11.76	63	441466	2339	42177467
Bladder cancer	20.31	11.76	99	441430	16948	42162858
Therapy non-responder	20.29	11.76	410	441119	52949	42126857
Grip strength decreased	20.23	11.76	6	441523	3582	42176224
Sinus node dysfunction	20.17	11.76	101	441428	4711	42175095
Cataract	20.14	11.76	211	441318	30393	42149413
Liver function test increased	20.05	11.76	123	441406	19875	42159931
Cytopenia	20.05	11.76	103	441426	17394	42162412
Pulmonary arterial pressure abnormal	20.02	11.76	21	441508	319	42179487
Tuberculosis	20.01	11.76	47	441482	10052	42169754
Hand deformity	20.01	11.76	7	441522	3761	42176045
Sinus arrhythmia	19.96	11.76	34	441495	843	42178963
Blindness	19.95	11.76	107	441422	17871	42161935
Ejection fraction	19.92	11.76	17	441512	196	42179610
Atrial septal defect	19.91	11.76	32	441497	7887	42171919
Oropharyngeal discomfort	19.91	11.76	9	441520	4140	42175666
Haematocrit decreased	19.90	11.76	488	441041	34420	42145386
International normalised ratio fluctuation	19.85	11.76	43	441486	1281	42178525
Asterixis	19.83	11.76	44	441485	1333	42178473
Hepatic enzyme increased	19.83	11.76	344	441185	45440	42134366
Jaundice cholestatic	19.77	11.76	107	441422	5146	42174660
Throat irritation	19.72	11.76	69	441460	12967	42166839
Accidental death	19.63	11.76	4	441525	3079	42176727
Nocardiosis	19.62	11.76	15	441514	5175	42174631
Adenovirus infection	19.61	11.76	25	441504	6784	42173022
Pulmonary function test abnormal	19.59	11.76	67	441462	2627	42177179
Anosmia	19.51	11.76	15	441514	5161	42174645
Apparent death	19.50	11.76	7	441522	3701	42176105
Gouty tophus	19.42	11.76	16	441513	175	42179631
Superinfection	19.40	11.76	71	441458	2880	42176926
Pneumocystis jirovecii pneumonia	19.39	11.76	167	441362	25014	42154792
Encephalopathy	19.31	11.76	563	440966	40770	42139036
Apathy	19.28	11.76	36	441493	8370	42171436
Melanoderma	19.28	11.76	16	441513	177	42179629
Jaundice	19.26	11.76	482	441047	34107	42145699
Amyloidosis	19.23	11.76	62	441467	2357	42177449
Total lung capacity abnormal	19.15	11.76	94	441435	4349	42175457
Gastrointestinal angiodysplasia	19.15	11.76	29	441500	649	42179157
Toxic skin eruption	19.08	11.76	222	441307	13508	42166298
Delusion	19.08	11.76	83	441446	14651	42165155
Long QT syndrome	19.00	11.76	74	441455	3093	42176713
Catatonia	18.93	11.76	22	441507	6217	42173589
Strongyloidiasis	18.87	11.76	6	441523	3425	42176381
Tendonitis	18.85	11.76	47	441482	9847	42169959
Rash erythematous	18.85	11.76	227	441302	31864	42147942
Arteriospasm coronary	18.81	11.76	13	441516	4725	42175081
Blood immunoglobulin E increased	18.80	11.76	7	441522	3618	42176188
Hypercholesterolaemia	18.78	11.76	69	441460	12780	42167026
Hypothyroidism	18.74	11.76	450	441079	31634	42148172
Enuresis	18.72	11.76	3	441526	2745	42177061
Hypercapnia	18.71	11.76	107	441422	5254	42174552
Maternal exposure during pregnancy	18.70	11.76	27	441502	6951	42172855
Right atrial hypertrophy	18.69	11.76	30	441499	707	42179099
Coagulation time prolonged	18.67	11.76	44	441485	1388	42178418
Eyelid ptosis	18.62	11.76	25	441504	6636	42173170
Coagulopathy	18.61	11.76	328	441201	21834	42157972
Gouty arthritis	18.57	11.76	40	441489	1187	42178619
Narrow anterior chamber angle	18.56	11.76	13	441516	109	42179697
Gastrointestinal toxicity	18.53	11.76	9	441520	3970	42175836
Anticoagulation drug level above therapeutic	18.47	11.76	64	441465	2526	42177280
Injection site urticaria	18.46	11.76	6	441523	3377	42176429
Right ventricular hypertrophy	18.43	11.76	46	441483	1506	42178300
Brain scan abnormal	18.30	11.76	40	441489	1199	42178607
Acute graft versus host disease in intestine	18.30	11.76	9	441520	3942	42175864
Urinary tract discomfort	18.28	11.76	13	441516	112	42179694
Myalgia	18.27	11.76	811	440718	95269	42084537
Drug screen positive	18.26	11.76	10	441519	4121	42175685
Status epilepticus	18.25	11.76	91	441438	15487	42164319
Bone pain	18.23	11.76	158	441371	23634	42156172
Ventricular dyssynchrony	18.20	11.76	7	441522	12	42179794
Pulmonary alveolar haemorrhage	18.18	11.76	234	441295	14582	42165224
Base excess decreased	18.10	11.76	16	441513	194	42179612
Nephrocalcinosis	18.10	11.76	31	441498	772	42179034
Transaminases increased	18.05	11.76	236	441293	32649	42147157
Bacterial infection	18.03	11.76	193	441336	27686	42152120
Left ventricle outflow tract obstruction	17.99	11.76	15	441514	167	42179639
Feeling abnormal	17.96	11.76	568	440961	69218	42110588
Atrial thrombosis	17.96	11.76	61	441468	2383	42177423
Cholestasis	17.96	11.76	457	441072	32422	42147384
Normocytic anaemia	17.86	11.76	79	441450	3498	42176308
Cytomegalovirus chorioretinitis	17.85	11.76	13	441516	4598	42175208
Acute myeloid leukaemia recurrent	17.85	11.76	7	441522	3505	42176301
Delayed graft function	17.83	11.76	64	441465	2571	42177235
Neuritis	17.83	11.76	118	441411	6102	42173704
Renal artery thrombosis	17.78	11.76	20	441509	330	42179476
Cardio-respiratory distress	17.76	11.76	14	441515	143	42179663
Dermatitis bullous	17.75	11.76	149	441380	8307	42171499
Lymphoma	17.74	11.76	82	441447	14239	42165567
Device difficult to use	17.74	11.76	13	441516	4583	42175223
Movement disorder	17.72	11.76	85	441444	14613	42165193
Intentional dose omission	17.67	11.76	42	441487	8944	42170862
Heparin-induced thrombocytopenia	17.63	11.76	123	441406	6474	42173332
Implantable defibrillator insertion	17.57	11.76	31	441498	791	42179015
Loss of libido	17.55	11.76	5	441524	3065	42176741
Peripheral venous disease	17.46	11.76	70	441459	2966	42176840
Partial seizures	17.41	11.76	21	441508	5838	42173968
Device pacing issue	17.37	11.76	10	441519	57	42179749
Right atrial enlargement	17.34	11.76	18	441511	270	42179536
Mitral valve replacement	17.30	11.76	15	441514	177	42179629
Depression suicidal	17.28	11.76	6	441523	3239	42176567
Adverse drug reaction	17.27	11.76	278	441251	37156	42142650
Miosis	17.25	11.76	76	441453	13370	42166436
Blood potassium abnormal	17.23	11.76	49	441480	1737	42178069
Virologic failure	17.18	11.76	10	441519	3984	42175822
Nocturnal dyspnoea	17.16	11.76	26	441503	582	42179224
Pulmonary tuberculosis	17.12	11.76	19	441510	5482	42174324
Multimorbidity	17.09	11.76	33	441496	904	42178902
Antipsychotic drug level increased	16.99	11.76	14	441515	4652	42175154
Hypochromasia	16.96	11.76	19	441510	312	42179494
Discomfort	16.95	11.76	173	441356	25046	42154760
Right atrial dilatation	16.92	11.76	20	441509	349	42179457
Blood bicarbonate increased	16.89	11.76	24	441505	506	42179300
Meningitis aseptic	16.88	11.76	13	441516	4469	42175337
Crying	16.88	11.76	25	441504	6369	42173437
Aspiration pleural cavity	16.81	11.76	32	441497	867	42178939
Procalcitonin decreased	16.74	11.76	17	441512	248	42179558
Hypertensive cardiomyopathy	16.71	11.76	14	441515	157	42179649
Aplastic anaemia	16.66	11.76	199	441330	12185	42167621
Pulmonary arterial pressure increased	16.63	11.76	44	441485	1494	42178312
Dependence on oxygen therapy	16.62	11.76	16	441513	218	42179588
Blood chloride increased	16.61	11.76	77	441452	3479	42176327
Brain oedema	16.59	11.76	100	441429	16227	42163579
Rebound effect	16.58	11.76	32	441497	7347	42172459
Ulcer	16.55	11.76	101	441428	16340	42163466
Heart sounds abnormal	16.54	11.76	32	441497	878	42178928
Abdominal cavity drainage	16.53	11.76	22	441507	435	42179371
Nasal congestion	16.46	11.76	211	441318	29290	42150516
Tongue oedema	16.45	11.76	73	441456	3237	42176569
Glomerular filtration rate	16.45	11.76	12	441517	108	42179698
Injection site rash	16.42	11.76	21	441508	5691	42174115
Electrocardiogram T wave amplitude decreased	16.36	11.76	20	441509	362	42179444
Alveolar lung disease	16.34	11.76	22	441507	440	42179366
Sleep terror	16.30	11.76	5	441524	2921	42176885
Cystitis haemorrhagic	16.28	11.76	32	441497	7297	42172509
Left ventricular end-diastolic pressure increased	16.26	11.76	15	441514	193	42179613
Base excess increased	16.26	11.76	9	441520	47	42179759
Diabetic foot	16.21	11.76	69	441460	3004	42176802
Immune-mediated enterocolitis	16.19	11.76	21	441508	5656	42174150
Hepatic steatosis	16.18	11.76	143	441386	21305	42158501
Circulatory collapse	16.15	11.76	339	441190	23297	42156509
Exposure via skin contact	16.12	11.76	17	441512	5021	42174785
Conjunctivitis	16.08	11.76	74	441455	12865	42166941
Fabry's disease	16.08	11.76	6	441523	9	42179797
Scrotal swelling	16.07	11.76	44	441485	1525	42178281
Hepatitis B	16.06	11.76	28	441501	6683	42173123
Nasal polyps	16.06	11.76	10	441519	3841	42175965
Brain natriuretic peptide abnormal	16.03	11.76	20	441509	370	42179436
Frequent bowel movements	16.03	11.76	143	441386	21264	42158542
Hypertensive emergency	16.00	11.76	39	441490	1258	42178548
Cardioactive drug level decreased	15.97	11.76	10	441519	68	42179738
Maternal drugs affecting foetus	15.97	11.76	10	441519	3829	42175977
Pulmonary arterial wedge pressure increased	15.93	11.76	12	441517	114	42179692
Musculoskeletal pain	15.92	11.76	246	441283	33094	42146712
Mycobacterial infection	15.91	11.76	4	441525	2664	42177142
Multiple organ dysfunction syndrome	15.90	11.76	1189	440340	95846	42083960
Diverticulum intestinal	15.89	11.76	99	441430	5014	42174792
Cerebral artery thrombosis	15.88	11.76	38	441491	1211	42178595
Blood sodium abnormal	15.86	11.76	25	441504	580	42179226
Abdominal wall haemorrhage	15.84	11.76	23	441506	495	42179311
Aortic valve calcification	15.72	11.76	24	441505	541	42179265
Ischaemic hepatitis	15.70	11.76	54	441475	2123	42177683
Alkalosis	15.65	11.76	13	441516	144	42179662
Pleuritic pain	15.63	11.76	31	441498	7046	42172760
Primary hyperaldosteronism	15.56	11.76	14	441515	174	42179632
Lower respiratory tract infection	15.55	11.76	317	441212	40889	42138917
Paracentesis	15.55	11.76	22	441507	462	42179344
Spontaneous haematoma	15.45	11.76	28	441501	730	42179076
Chest pain	15.38	11.76	1661	439868	137869	42041937
Right ventricular systolic pressure decreased	15.38	11.76	8	441521	36	42179770
Chronic left ventricular failure	15.35	11.76	28	441501	734	42179072
Osmotic demyelination syndrome	15.33	11.76	33	441496	979	42178827
Myocarditis	15.30	11.76	124	441405	18814	42160992
Restlessness	15.29	11.76	212	441317	29037	42150769
Blood sodium increased	15.27	11.76	70	441459	3148	42176658
Blood pressure systolic abnormal	15.20	11.76	21	441508	5507	42174299
Unintentional medical device removal	15.19	11.76	7	441522	3184	42176622
Iron deficiency	15.13	11.76	61	441468	11000	42168806
Mitral valve disease	15.13	11.76	42	441487	1468	42178338
Social avoidant behaviour	15.08	11.76	8	441521	3356	42176450
Diffuse large B-cell lymphoma recurrent	15.07	11.76	17	441512	4869	42174937
Injection site discomfort	15.03	11.76	3	441526	2343	42177463
C-reactive protein increased	15.02	11.76	523	441006	63037	42116769
Urine calcium decreased	15.01	11.76	6	441523	12	42179794
Mydriasis	14.95	11.76	44	441485	8726	42171080
Inspiratory capacity decreased	14.94	11.76	6	441523	2961	42176845
Acquired macroglossia	14.89	11.76	7	441522	24	42179782
Pulmonary vein stenosis	14.88	11.76	8	441521	39	42179767
Blood urea abnormal	14.88	11.76	35	441494	1103	42178703
Metastases to central nervous system	14.87	11.76	56	441473	10299	42169507
Sphincter of Oddi dysfunction	14.82	11.76	15	441514	218	42179588
Ventricular dyskinesia	14.75	11.76	16	441513	253	42179553
Gastric varices	14.72	11.76	26	441503	664	42179142
Psychotic disorder due to a general medical condition	14.66	11.76	10	441519	80	42179726
Localised oedema	14.63	11.76	82	441447	3996	42175810
Peripheral arterial occlusive disease	14.62	11.76	121	441408	6717	42173089
Lymphoproliferative disorder	14.62	11.76	8	441521	3299	42176507
Local anaesthetic systemic toxicity	14.61	11.76	3	441526	2297	42177509
Skin lesion	14.55	11.76	196	441333	26978	42152828
Bundle branch block right	14.53	11.76	138	441391	7968	42171838
Attention deficit hyperactivity disorder	14.52	11.76	7	441522	3101	42176705
Speech disorder developmental	14.48	11.76	3	441526	2282	42177524
Papilloedema	14.46	11.76	8	441521	3278	42176528
Thinking abnormal	14.45	11.76	33	441496	7128	42172678
Phlebitis deep	14.40	11.76	6	441523	14	42179792
Portopulmonary hypertension	14.40	11.76	6	441523	14	42179792
Extubation	14.32	11.76	4	441525	0	42179806
Gastritis haemorrhagic	14.31	11.76	44	441485	1630	42178176
Volume blood decreased	14.29	11.76	15	441514	228	42179578
Red cell distribution width increased	14.24	11.76	122	441407	6842	42172964
Sensation of foreign body	14.23	11.76	10	441519	3603	42176203
Strangury	14.22	11.76	12	441517	136	42179670
Cardiac pacemaker insertion	14.20	11.76	69	441460	3179	42176627
Drug level below therapeutic	14.17	11.76	29	441500	6516	42173290
Pericardial fibrosis	14.17	11.76	13	441516	166	42179640
Intestinal obstruction	14.15	11.76	197	441332	26961	42152845
Muscle spasticity	14.13	11.76	31	441498	6791	42173015
Peritoneal cloudy effluent	14.08	11.76	19	441510	381	42179425
Gastrointestinal arteriovenous malformation	14.06	11.76	18	441511	342	42179464
Malignant melanoma	14.05	11.76	50	441479	9350	42170456
Tension headache	14.05	11.76	9	441520	3405	42176401
Cardiac ablation	14.05	11.76	37	441492	1253	42178553
Fear of death	14.00	11.76	24	441505	598	42179208
Ventricular flutter	13.98	11.76	10	441519	87	42179719
Osteolysis	13.98	11.76	10	441519	3570	42176236
Hepatitis	13.88	11.76	199	441330	27101	42152705
Myocardiac abscess	13.84	11.76	8	441521	46	42179760
Joint injury	13.83	11.76	92	441437	14584	42165222
Abnormal dreams	13.74	11.76	42	441487	8229	42171577
Endocarditis	13.74	11.76	137	441392	8015	42171791
Upper motor neurone lesion	13.69	11.76	13	441516	174	42179632
Blood alkaline phosphatase increased	13.67	11.76	450	441079	33147	42146659
Transfusion-related acute lung injury	13.64	11.76	14	441515	207	42179599
Oxygen consumption increased	13.62	11.76	43	441486	1616	42178190
Neonatal respiratory distress syndrome	13.60	11.76	16	441513	4497	42175309
Urine protein/creatinine ratio decreased	13.60	11.76	5	441524	7	42179799
Paroxysmal arrhythmia	13.60	11.76	5	441524	7	42179799
Agranulocytosis	13.50	11.76	414	441115	30198	42149608
Renal cancer	13.49	11.76	42	441487	8182	42171624
Nephrosclerosis	13.47	11.76	32	441497	1015	42178791
Renal cyst haemorrhage	13.45	11.76	25	441504	665	42179141
Haemorrhagic diathesis	13.41	11.76	67	441462	3122	42176684
Red blood cell sedimentation rate increased	13.41	11.76	55	441474	9869	42169937
Type I hypersensitivity	13.40	11.76	3	441526	2163	42177643
Mumps	13.36	11.76	10	441519	94	42179712
Cardioversion	13.32	11.76	31	441498	970	42178836
Cardiac resynchronisation therapy	13.31	11.76	8	441521	50	42179756
Blood bicarbonate decreased	13.30	11.76	63	441466	2872	42176934
Haemorrhagic arteriovenous malformation	13.26	11.76	18	441511	363	42179443
Road traffic accident	13.24	11.76	130	441399	18963	42160843
Optic neuritis	13.23	11.76	14	441515	4128	42175678
Osteonecrosis	13.23	11.76	103	441426	15762	42164044
Device breakage	13.22	11.76	11	441518	3638	42176168
Uraemic encephalopathy	13.22	11.76	19	441510	405	42179401
Chest X-ray abnormal	13.21	11.76	86	441443	4422	42175384
Hospitalisation	13.20	11.76	632	440897	73698	42106108
Product substitution issue	13.20	11.76	66	441463	11224	42168582
Hot flush	13.17	11.76	158	441371	22193	42157613
Squamous cell carcinoma	12.93	11.76	80	441449	12902	42166904
Loss of personal independence in daily activities	12.93	11.76	405	441124	49411	42130395
Transplant rejection	12.89	11.76	85	441444	13503	42166303
Lividity	12.85	11.76	12	441517	157	42179649
Enteropathy-associated T-cell lymphoma	12.85	11.76	5	441524	9	42179797
Skin fissures	12.84	11.76	54	441475	9622	42170184
Bipolar disorder	12.82	11.76	13	441516	3909	42175897
Pseudohyponatraemia	12.81	11.76	11	441518	128	42179678
Tenderness	12.79	11.76	48	441481	8835	42170971
Pain of skin	12.74	11.76	42	441487	8038	42171768
Body temperature increased	12.74	11.76	142	441387	20216	42159590
Histoplasmosis disseminated	12.73	11.76	3	441526	2088	42177718
Osteoarthritis	12.72	11.76	177	441352	24228	42155578
Bradykinesia	12.72	11.76	23	441506	5413	42174393
Product quality issue	12.72	11.76	121	441408	17761	42162045
Kidney small	12.70	11.76	8	441521	55	42179751
Cirrhosis alcoholic	12.67	11.76	27	441502	795	42179011
Pneumonitis	12.64	11.76	332	441197	41386	42138420
Pericardial drainage	12.62	11.76	10	441519	103	42179703
Pulmonary fibrosis	12.62	11.76	364	441165	26317	42153489
Bronchial secretion retention	12.60	11.76	41	441488	1566	42178240
Inflammation	12.59	11.76	261	441268	33586	42146220
Therapeutic embolisation	12.58	11.76	16	441513	302	42179504
Granuloma	12.53	11.76	14	441515	4027	42175779
Pulmonary hypertensive crisis	12.52	11.76	13	441516	195	42179611
Capillaritis	12.52	11.76	51	441478	2177	42177629
Blood creatine decreased	12.51	11.76	15	441514	266	42179540
Cryptococcosis	12.50	11.76	9	441520	3202	42176604
Pulmonary veno-occlusive disease	12.50	11.76	23	441506	607	42179199
Rhinorrhoea	12.48	11.76	243	441286	31551	42148255
Degenerative aortic valve disease	12.47	11.76	6	441523	22	42179784
Initial insomnia	12.45	11.76	14	441515	4016	42175790
Mouth haemorrhage	12.45	11.76	109	441420	6152	42173654
Subarachnoid haemorrhage	12.44	11.76	215	441314	14257	42165549
Prostate cancer stage II	12.43	11.76	4	441525	2266	42177540
Tooth infection	12.39	11.76	42	441487	7969	42171837
Visual field defect	12.37	11.76	20	441509	4918	42174888
Prothrombin level increased	12.31	11.76	13	441516	199	42179607
Behaviour disorder	12.31	11.76	35	441494	7019	42172787
Large intestine benign neoplasm	12.27	11.76	6	441523	23	42179783
Posterior reversible encephalopathy syndrome	12.27	11.76	80	441449	12741	42167065
Osteonecrosis of jaw	12.26	11.76	132	441397	18917	42160889
Troponin increased	12.26	11.76	271	441258	18791	42161015
Blood magnesium increased	12.25	11.76	27	441502	814	42178992
Lymphocyte stimulation test positive	12.24	11.76	23	441506	617	42179189
Blood glucose increased	12.23	11.76	904	440625	72795	42107011
Wrong technique in product usage process	12.21	11.76	342	441187	42293	42137513
Ketoacidosis	12.21	11.76	23	441506	5329	42174477
Epstein-Barr virus associated lymphoproliferative disorder	12.20	11.76	5	441524	2438	42177368
Rheumatoid nodule	12.18	11.76	8	441521	2987	42176819
Fracture	12.18	11.76	43	441486	8060	42171746
Cryptorchism	12.16	11.76	3	441526	2024	42177782
Hepatic function abnormal	12.14	11.76	652	440877	50915	42128891
Talipes	12.14	11.76	4	441525	2232	42177574
Pleuroperitoneal communication	12.11	11.76	4	441525	3	42179803
Continuous haemodiafiltration	12.10	11.76	29	441500	925	42178881
Intestinal stenosis	12.09	11.76	7	441522	2797	42177009
Pseudo-Bartter syndrome	12.07	11.76	6	441523	24	42179782
Aphthous ulcer	12.07	11.76	27	441502	5874	42173932
Oesophageal perforation	12.06	11.76	34	441495	1199	42178607
Mobility decreased	12.05	11.76	276	441253	35030	42144776
Blood lactic acid decreased	12.04	11.76	8	441521	61	42179745
Soft tissue mass	12.03	11.76	30	441499	982	42178824
Duodenal ulcer haemorrhage	12.01	11.76	102	441427	5706	42174100
Hypopituitarism	11.99	11.76	7	441522	2784	42177022
Asphyxia	11.98	11.76	45	441484	8281	42171525
Interstitial lung disease	11.95	11.76	956	440573	77506	42102300
Fear of injection	11.95	11.76	3	441526	2000	42177806
Ataxia	11.95	11.76	108	441421	16017	42163789
Urine potassium increased	11.91	11.76	5	441524	12	42179794
Blood luteinising hormone increased	11.90	11.76	9	441520	86	42179720
Diffuse large B-cell lymphoma refractory	11.90	11.76	3	441526	1994	42177812
Electrocardiogram QRS complex abnormal	11.89	11.76	19	441510	446	42179360
Lip swelling	11.88	11.76	133	441396	18920	42160886
Gastric ulcer haemorrhage	11.84	11.76	106	441423	6021	42173785
Chronic respiratory failure	11.80	11.76	42	441487	1680	42178126

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	7438.13	10.62	15822	857094	619608	109096775
Cardiac failure congestive	4918.71	10.62	6010	866906	144990	109571393
Cardiac failure	3526.31	10.62	5739	867177	181887	109534496
Hyperkalaemia	3260.25	10.62	4655	868261	131141	109585242
Hypotension	2247.19	10.62	9125	863791	514724	109201659
Renal failure	1908.12	10.62	4974	867942	221600	109494783
Drug ineffective	1846.98	10.62	6023	866893	1514517	108201866
Hyponatraemia	1677.07	10.62	4624	868292	213029	109503354
Hand deformity	1604.10	10.62	23	872893	218483	109497900
International normalised ratio increased	1584.83	10.62	2622	870294	84150	109632233
Pemphigus	1532.29	10.62	33	872883	214537	109501846
Atrial fibrillation	1490.70	10.62	4589	868327	225053	109491330
Drug interaction	1451.17	10.62	7776	865140	492407	109223976
Hypokalaemia	1440.98	10.62	3912	869004	178536	109537847
Anti-cyclic citrullinated peptide antibody positive	1416.12	10.62	3	872913	181981	109534402
Synovitis	1415.64	10.62	232	872684	273860	109442523
Glossodynia	1396.73	10.62	90	872826	221914	109494469
Dyspnoea	1336.37	10.62	13963	858953	1092909	108623474
Oedema peripheral	1303.11	10.62	5593	867323	323067	109393316
Off label use	1295.56	10.62	6780	866136	1493405	108222978
Duodenal ulcer perforation	1254.55	10.62	31	872885	177669	109538714
Arthropathy	1246.92	10.62	361	872555	287161	109429222
Pericarditis	1159.62	10.62	173	872743	218941	109497442
Helicobacter infection	1155.22	10.62	70	872846	181807	109534576
Systemic lupus erythematosus	1148.53	10.62	295	872621	254043	109462340
Folliculitis	1117.07	10.62	48	872868	167605	109548778
Bradycardia	1110.25	10.62	3215	869701	152302	109564081
Alopecia	1106.77	10.62	762	872154	363991	109352392
Drug intolerance	1098.05	10.62	956	871960	405556	109310827
Infusion related reaction	1097.07	10.62	842	872074	380320	109336063
Renal impairment	1095.08	10.62	3626	869290	184819	109531564
Anaemia	1073	10.62	7691	865225	539395	109176988
Therapeutic product effect decreased	1051.49	10.62	311	872605	244005	109472378
Dehydration	1035.57	10.62	4662	868254	274849	109441534
Blood creatinine increased	1013.93	10.62	3464	869452	179425	109536958
Psoriatic arthropathy	999.31	10.62	174	872742	196587	109519796
Rheumatoid factor positive	997.69	10.62	7	872909	131633	109584750
Muscle injury	981.03	10.62	28	872888	140779	109575604
Fall	972.22	10.62	8104	864812	595378	109121005
Maternal exposure during pregnancy	941.66	10.62	416	872500	254467	109461916
Rheumatic fever	931.59	10.62	6	872910	122573	109593810
Pulmonary hypertension	925.14	10.62	1606	871310	53614	109662769
Irritable bowel syndrome	915.67	10.62	110	872806	164105	109552278
Myocardial infarction	903.21	10.62	3448	869468	188635	109527748
Treatment failure	895.63	10.62	539	872377	276695	109439688
Melaena	873.08	10.62	1776	871140	66981	109649402
Wound	856.02	10.62	389	872527	234048	109482335
Gastrointestinal haemorrhage	847.43	10.62	3054	869862	162464	109553919
Drug hypersensitivity	842.94	10.62	1430	871486	452660	109263723
Musculoskeletal stiffness	825.66	10.62	602	872314	279220	109437163
Syncope	819.86	10.62	3470	869446	199066	109517317
Joint swelling	809.71	10.62	1408	871508	441437	109274946
Arthralgia	807.79	10.62	3291	869625	776341	108940042
Blood urea increased	800.40	10.62	1504	871412	53453	109662930
Hypersensitivity	794.10	10.62	1225	871691	402773	109313610
Rheumatoid arthritis	793.81	10.62	717	872199	298896	109417487
Orthostatic hypotension	788.14	10.62	1666	871250	64583	109651800
Sleep disorder due to general medical condition, insomnia type	751.08	10.62	17	872899	105626	109610757
Fluid retention	738.86	10.62	2017	870899	92290	109624093
Impaired healing	734.54	10.62	316	872600	196401	109519982
Discomfort	732.76	10.62	390	872526	214317	109502066
Lactic acidosis	726.12	10.62	1984	870932	90827	109625556
Hypoglycaemia	723.80	10.62	2289	870627	113815	109602568
Facet joint syndrome	720.15	10.62	8	872908	96820	109619563
Hepatic enzyme increased	718.85	10.62	885	872031	320007	109396376
Lip dry	700.50	10.62	19	872897	100064	109616319
Pulmonary arterial hypertension	699.12	10.62	1060	871856	31508	109684875
C-reactive protein abnormal	696.28	10.62	98	872818	129597	109586786
Abdominal discomfort	692.24	10.62	1283	871633	392575	109323808
Cardiac failure chronic	679.52	10.62	683	872233	13128	109703255
Contraindicated product administered	677.04	10.62	578	872338	247689	109468694
Pulmonary oedema	665.87	10.62	2026	870890	98633	109617750
Sinusitis	656.39	10.62	826	872090	295862	109420521
Fibromyalgia	653.45	10.62	265	872651	170644	109545739
Swollen joint count increased	636.18	10.62	4	872912	83657	109632726
Nasopharyngitis	621.83	10.62	1368	871548	392993	109323390
Ill-defined disorder	619.84	10.62	231	872685	156622	109559761
Gastrointestinal disorder	616.09	10.62	600	872316	241352	109475031
Stomatitis	606.56	10.62	744	872172	269498	109446885
Pleural effusion	605.92	10.62	2894	870022	174815	109541568
Hypervolaemia	604.82	10.62	1258	871658	48202	109668181
Chronic kidney disease	601.88	10.62	1636	871280	74655	109641728
Intentional product use issue	589.22	10.62	652	872264	247254	109469129
Type 2 diabetes mellitus	577.24	10.62	341	872575	176891	109539492
Product use in unapproved indication	567.30	10.62	1732	871184	445645	109270738
Right ventricular failure	563.14	10.62	849	872067	25105	109691278
Urticaria	553.66	10.62	1046	871870	317811	109398572
Sleep disorder	540.89	10.62	463	872453	198181	109518202
Joint range of motion decreased	533.33	10.62	150	872766	121682	109594701
Night sweats	531.62	10.62	196	872720	133787	109582596
Hepatic encephalopathy	529.34	10.62	864	872052	27392	109688991
Blood cholesterol increased	528.89	10.62	410	872506	184375	109532008
Pain	517.19	10.62	4933	867983	950022	108766361
Grip strength decreased	508.54	10.62	31	872885	80143	109636240
Swelling	461.47	10.62	1336	871580	349705	109366678
Liver injury	454.74	10.62	315	872601	150098	109566285
Therapeutic product effect incomplete	452.55	10.62	665	872251	223140	109493243
Completed suicide	444.96	10.62	768	872148	241613	109474770
Respiratory failure	444.67	10.62	3068	869848	212264	109504119
Death	443.21	10.62	7862	865054	691007	109025376
Hypoaesthesia	437.45	10.62	1163	871753	313060	109403323
Rash	436.45	10.62	4259	868657	816705	108899678
Ascites	430.16	10.62	1659	871257	91149	109625234
Lower respiratory tract infection	424.99	10.62	794	872122	242312	109474071
Product use issue	423.86	10.62	1167	871749	310528	109405855
Inflammation	422.02	10.62	543	872373	192695	109523688
Metabolic alkalosis	414.60	10.62	348	872568	5247	109711136
Rhabdomyolysis	414.06	10.62	1966	870950	118435	109597948
Haemoglobin decreased	410.89	10.62	3362	869554	245365	109471018
Blepharospasm	410.32	10.62	4	872912	54847	109661536
Ventricular tachycardia	409.10	10.62	1087	871829	48922	109667461
Injection site reaction	404.36	10.62	102	872814	88968	109627415
Dry mouth	399.48	10.62	599	872317	199349	109517034
Dyspnoea exertional	398.59	10.62	1754	871162	102306	109614077
Coronary artery disease	397.03	10.62	1358	871558	70332	109646051
Drug abuse	390.03	10.62	496	872420	176915	109539468
Bursitis	388.87	10.62	275	872641	129643	109586740
Cardiac failure acute	387.29	10.62	688	872228	23390	109692993
Acute myocardial infarction	381.27	10.62	1489	871427	82288	109634095
Torsade de pointes	374.16	10.62	654	872262	21946	109694437
Haematoma	373.61	10.62	1163	871753	57313	109659070
Osteoarthritis	360.09	10.62	552	872364	182071	109534312
Live birth	349.26	10.62	63	872853	69421	109646962
Blister	340.88	10.62	810	872106	226566	109489817
Peripheral venous disease	340.56	10.62	119	872797	83998	109632385
Hypovolaemia	340.52	10.62	613	872303	21061	109695322
Wound infection	339.74	10.62	168	872748	96297	109620086
Autoimmune disorder	332.13	10.62	58	872858	65425	109650958
Hypercholesterolaemia	330.96	10.62	151	872765	90686	109625697
Infection	329.40	10.62	1603	871313	360597	109355786
Orthopnoea	328.32	10.62	420	872496	10601	109705782
Mitral valve incompetence	322.31	10.62	772	872144	32557	109683826
Musculoskeletal pain	316.97	10.62	601	872315	182422	109533961
Paraesthesia	314.03	10.62	1123	871793	275398	109440985
Adjustment disorder with depressed mood	312.14	10.62	7	872909	43876	109672507
Epistaxis	308.85	10.62	1923	870993	128449	109587934
Red blood cell sedimentation rate increased	308.14	10.62	116	872800	78186	109638197
Obesity	305.07	10.62	267	872649	113084	109603299
Migraine	304.92	10.62	555	872361	171097	109545286
Generalised oedema	299.94	10.62	714	872202	29990	109686393
Blood pressure decreased	295.13	10.62	1733	871183	113358	109603025
Sciatica	294.87	10.62	182	872734	92217	109624166
Electrocardiogram QT prolonged	294.64	10.62	1664	871252	107296	109609087
N-terminal prohormone brain natriuretic peptide increased	294.34	10.62	299	872617	5822	109710561
Creatinine renal clearance decreased	293.01	10.62	577	872339	21238	109695145
Injection site pain	291.96	10.62	603	872313	177319	109539064
Cardiomegaly	291.73	10.62	684	872232	28446	109687937
Road traffic accident	287.80	10.62	254	872662	107144	109609239
Cardiac arrest	287.28	10.62	2588	870328	194165	109522218
Hypoxia	284.40	10.62	1874	871042	127641	109588742
Suicide attempt	283.80	10.62	239	872677	103155	109613228
Nail disorder	283.79	10.62	56	872860	57879	109658504
Onychomadesis	282.67	10.62	20	872896	45643	109670740
Cardioactive drug level increased	280.54	10.62	238	872678	3644	109712739
Sopor	277.54	10.62	773	872143	35773	109680610
Pregnancy	273.08	10.62	39	872877	51028	109665355
Intentional overdose	272.39	10.62	389	872527	132112	109584271
Blood potassium increased	272.23	10.62	723	872193	32526	109683857
Bone erosion	271.33	10.62	26	872890	46345	109670038
Urine output decreased	269.73	10.62	528	872388	19348	109697035
Wheezing	262.40	10.62	1079	871837	254151	109462232
Exposure during pregnancy	260.11	10.62	585	872331	166839	109549544
Headache	259.96	10.62	5157	867759	877220	108839163
Hepatic failure	259.67	10.62	1154	871762	67585	109648798
Injection site erythema	259.33	10.62	217	872699	93959	109622424
Shock haemorrhagic	257.98	10.62	626	872290	26621	109689762
Chronic obstructive pulmonary disease	255.35	10.62	1605	871311	107553	109608830
Hypocalcaemia	253.46	10.62	1106	871810	64260	109652123
Presyncope	246.52	10.62	898	872018	47989	109668394
Cardiac disorder	245.98	10.62	1223	871693	75057	109641326
Hypomagnesaemia	244.49	10.62	1035	871881	59335	109657048
Lower limb fracture	238.23	10.62	150	872766	75198	109641185
Ejection fraction decreased	236.58	10.62	786	872130	40094	109676289
Myelosuppression	235.33	10.62	238	872678	94102	109622281
Retinitis	234.58	10.62	4	872912	32323	109684060
Cerebrovascular accident	232.51	10.62	2320	870596	178964	109537419
X-ray abnormal	232.22	10.62	18	872898	38099	109678284
Hip arthroplasty	229.32	10.62	77	872839	55736	109660647
BRASH syndrome	228.46	10.62	208	872708	3515	109712868
Gait inability	228.15	10.62	457	872459	135919	109580464
Anuria	227.01	10.62	556	872360	23785	109692598
Pneumonia	226.39	10.62	8756	864160	867958	108848425
Hypernatraemia	225.53	10.62	460	872456	17373	109699010
Haematuria	222.00	10.62	1264	871652	81741	109634642
Renal injury	221.79	10.62	470	872446	18243	109698140
Oedema	219.19	10.62	2579	870337	207397	109508986
Brain natriuretic peptide increased	217.09	10.62	348	872568	10861	109705522
Knee arthroplasty	217.04	10.62	121	872795	64827	109651556
Multiple organ dysfunction syndrome	214.53	10.62	1982	870934	149728	109566655
Glomerular filtration rate decreased	210.62	10.62	603	872313	28353	109688030
Acute respiratory failure	210.52	10.62	1160	871756	74100	109642283
Blood potassium decreased	208.57	10.62	914	872002	53200	109663183
Ischaemic cardiomyopathy	207.37	10.62	285	872631	7726	109708657
Atrioventricular block	207.15	10.62	430	872486	16447	109699936
Drug ineffective for unapproved indication	205.40	10.62	308	872608	102530	109613853
Memory impairment	204.01	10.62	830	872086	196114	109520269
Taste disorder	202.86	10.62	133	872783	65254	109651129
Acute pulmonary oedema	201.58	10.62	427	872489	16569	109699814
Cardiogenic shock	200.50	10.62	941	871975	56397	109659986
Mobility decreased	198.63	10.62	1081	871835	236341	109480042
Transfusion	198.60	10.62	544	872372	24928	109691455
Rectal haemorrhage	197.81	10.62	1620	871296	118213	109598170
Haematemesis	197.23	10.62	957	871959	58151	109658232
Arrhythmia	197.04	10.62	1076	871840	68499	109647884
Onychomycosis	195.68	10.62	34	872882	38497	109677886
Cellulitis	195.48	10.62	1680	871236	124336	109592047
Subdural haematoma	195.24	10.62	683	872233	35771	109680612
Pericardial effusion	194.24	10.62	931	871985	56286	109660097
Pruritus	192.73	10.62	3329	869587	578231	109138152
Tricuspid valve incompetence	192.29	10.62	516	872400	23357	109693026
Toxic epidermal necrolysis	191.83	10.62	922	871994	55805	109660578
Insomnia	188.76	10.62	1876	871040	358714	109357669
Breast cancer stage II	188.60	10.62	6	872910	27369	109689014
Pemphigoid	187.89	10.62	454	872462	19253	109697130
Oliguria	187.82	10.62	439	872477	18218	109698165
Atrial flutter	187.02	10.62	516	872400	23746	109692637
Rales	186.60	10.62	522	872394	24217	109692166
Injection site swelling	185.91	10.62	130	872786	61660	109654723
Gout	185.48	10.62	673	872243	35893	109680490
Epilepsy	184.25	10.62	317	872599	99892	109616491
Congestive cardiomyopathy	183.65	10.62	370	872546	13849	109702534
Asthenia	182.06	10.62	6900	866016	682099	109034284
Metabolic acidosis	181.99	10.62	1380	871536	98364	109618019
C-reactive protein increased	181.84	10.62	993	871923	216926	109499457
Dyspepsia	181.17	10.62	832	872084	190133	109526250
Cardiomyopathy	179.44	10.62	628	872288	32897	109683486
Haemoptysis	179.39	10.62	1069	871847	70285	109646098
Liver function test increased	177.04	10.62	265	872651	88283	109628100
Laryngitis	176.90	10.62	57	872859	42354	109674029
Device expulsion	176.37	10.62	19	872897	30872	109685511
Product quality issue	176.25	10.62	210	872706	77089	109639294
Abdominal pain upper	172.17	10.62	1842	871074	347269	109369114
Blood calcium decreased	171.16	10.62	647	872269	35198	109681185
Adverse event	169.95	10.62	379	872537	108430	109607953
Lupus-like syndrome	169.83	10.62	55	872861	40737	109675646
Respiratory distress	168.78	10.62	1025	871891	67849	109648534
Upper gastrointestinal haemorrhage	167.07	10.62	811	872105	49285	109667098
Red blood cell sedimentation rate abnormal	166.64	10.62	6	872910	24503	109691880
Fatigue	166.35	10.62	7876	865040	1208082	108508301
Myocardial ischaemia	166.09	10.62	526	872390	26158	109690225
Eosinophilia	164.73	10.62	897	872019	57039	109659344
Adverse drug reaction	163.79	10.62	369	872547	105190	109611193
Depressed level of consciousness	162.84	10.62	1475	871441	110803	109605580
Suicidal ideation	162.11	10.62	309	872607	93628	109622755
Back injury	161.74	10.62	86	872830	47313	109669070
Hyperuricaemia	160.82	10.62	355	872561	14176	109702207
Sepsis	159.88	10.62	3543	869373	323803	109392580
Ischaemic stroke	159.06	10.62	697	872219	40566	109675817
Injury	158.98	10.62	788	872128	176477	109539906
Cerebral haemorrhage	158.02	10.62	965	871951	64003	109652380
Haemodialysis	156.04	10.62	396	872520	17323	109699060
Incorrect route of product administration	155.94	10.62	165	872751	63896	109652487
Foot deformity	155.35	10.62	95	872821	48385	109667998
Left ventricular failure	152.67	10.62	301	872615	11088	109705295
Atrioventricular block complete	151.73	10.62	424	872492	19658	109696725
Colitis ulcerative	150.37	10.62	236	872680	77127	109639256
Abortion spontaneous	148.53	10.62	43	872873	34239	109682144
Unevaluable event	147.40	10.62	885	872031	58342	109658041
Blood loss anaemia	145.58	10.62	390	872526	17635	109698748
Loss of consciousness	145.44	10.62	2267	870649	194039	109522344
Dialysis	145.07	10.62	411	872505	19208	109697175
Inappropriate schedule of product administration	144.68	10.62	976	871940	202661	109513722
Drug tolerance decreased	142.74	10.62	23	872893	27517	109688866
Azotaemia	141.84	10.62	272	872644	9813	109706570
Ear infection	141.35	10.62	172	872744	62560	109653823
Injection site pruritus	140.01	10.62	119	872797	51139	109665244
Joint stiffness	138.58	10.62	197	872719	67046	109649337
Nausea	137.61	10.62	8170	864746	1227520	108488863
Gravitational oedema	136.41	10.62	116	872800	1782	109714601
Sedation complication	136.27	10.62	405	872511	19450	109696933
Exostosis	135.23	10.62	99	872817	45857	109670526
Pseudo-Bartter syndrome	134.32	10.62	46	872870	72	109716311
Finger deformity	133.62	10.62	47	872869	33045	109683338
Coronary artery bypass	132.99	10.62	199	872717	5843	109710540
Nephrocalcinosis	132.70	10.62	112	872804	1702	109714681
Fear	132.47	10.62	444	872472	22749	109693634
Pulmonary congestion	130.14	10.62	537	872379	30429	109685954
Prothrombin time prolonged	129.98	10.62	364	872552	16897	109699486
Head injury	129.78	10.62	677	872239	42340	109674043
Asthma	129.31	10.62	1306	871610	248985	109467398
Therapeutic response decreased	129.01	10.62	364	872552	96135	109620248
Blood bilirubin increased	128.57	10.62	1033	871883	74939	109641444
Accidental exposure to product	128.35	10.62	123	872793	49885	109666498
Cardio-respiratory arrest	126.28	10.62	1435	871481	114401	109601982
Adverse reaction	124.81	10.62	39	872877	29555	109686828
General physical health deterioration	124.10	10.62	2488	870428	422807	109293576
Toxic skin eruption	123.49	10.62	487	872429	27028	109689355
Sudden death	122.89	10.62	448	872468	23947	109692436
Blood sodium decreased	122.54	10.62	613	872303	37706	109678677
Oxygen saturation decreased	122.48	10.62	1829	871087	155153	109561230
Drug reaction with eosinophilia and systemic symptoms	122.37	10.62	1085	871831	81010	109635373
Exercise tolerance decreased	121.53	10.62	284	872632	11783	109704600
Polyuria	120.96	10.62	361	872555	17377	109699006
Amnesia	120.94	10.62	426	872490	104982	109611401
Bundle branch block left	120.83	10.62	295	872621	12593	109703790
Prerenal failure	120.52	10.62	162	872754	4297	109712086
International normalised ratio decreased	119.38	10.62	225	872691	8011	109708372
Ventricular extrasystoles	119.34	10.62	422	872494	22219	109694164
Arthritis	119.14	10.62	803	872113	166783	109549600
Bradyarrhythmia	118.00	10.62	169	872747	4765	109711618
Iron deficiency anaemia	117.04	10.62	527	872389	31032	109685351
Aortic valve incompetence	116.73	10.62	264	872652	10717	109705666
Neck pain	116.43	10.62	537	872379	122593	109593790
Muscle spasms	116.15	10.62	1522	871394	276635	109439748
Balance disorder	116.02	10.62	1419	871497	115141	109601242
Jaundice	115.69	10.62	833	872083	58403	109657980
COVID-19	115.18	10.62	1307	871609	243753	109472630
Febrile neutropenia	114.07	10.62	1785	871131	314982	109401401
Psychotic disorder	113.36	10.62	141	872775	50796	109665587
Frequent bowel movements	112.84	10.62	247	872669	71143	109645240
Gastrointestinal tract mucosal pigmentation	112.76	10.62	88	872828	1189	109715194
Hypochloraemia	112.72	10.62	141	872775	3477	109712906
Rheumatoid nodule	112.09	10.62	14	872902	20282	109696101
Muscle spasticity	111.47	10.62	73	872843	35842	109680541
Venous pressure jugular increased	110.45	10.62	89	872827	1263	109715120
Maternal exposure timing unspecified	110.15	10.62	17	872899	20996	109695387
Lower gastrointestinal haemorrhage	110.15	10.62	359	872557	18127	109698256
Therapy partial responder	110.14	10.62	79	872837	36982	109679401
Concomitant disease aggravated	109.67	10.62	331	872585	16033	109700350
Left ventricular dysfunction	109.65	10.62	421	872495	23072	109693311
Multiple sclerosis relapse	107.74	10.62	143	872773	50097	109666286
Blood creatine increased	107.25	10.62	263	872653	11258	109705125
Depression	106.72	10.62	1811	871105	315524	109400859
Blood alkaline phosphatase increased	106.49	10.62	939	871977	69996	109646387
Sinus bradycardia	104.64	10.62	486	872430	28997	109687386
Drug resistance	103.93	10.62	178	872738	56196	109660187
Anhedonia	102.39	10.62	311	872605	15117	109701266
Anxiety	102.36	10.62	2013	870903	343065	109373318
Prescribed underdose	101.77	10.62	227	872689	64947	109651436
Faeces discoloured	100.85	10.62	532	872384	33416	109682967
Intentional product misuse	100.47	10.62	625	872291	132279	109584104
Pyrexia	99.93	10.62	5938	866978	892327	108824056
Prescribed overdose	99.78	10.62	355	872561	87226	109629157
Jugular vein distension	98.61	10.62	90	872826	1526	109714857
Joint dislocation	97.59	10.62	76	872840	34114	109682269
Cardiac output decreased	97.54	10.62	100	872816	1969	109714414
Anaphylactic reaction	97.43	10.62	517	872399	113783	109602600
Psoriasis	97.41	10.62	675	872241	139318	109577065
Hypovolaemic shock	96.81	10.62	294	872622	14289	109702094
No adverse event	95.43	10.62	283	872633	73556	109642827
Hypoglycaemic coma	95.35	10.62	163	872753	5370	109711013
Injection site bruising	95.29	10.62	161	872755	51102	109665281
Septic shock	94.74	10.62	1759	871157	155769	109560614
Feeling hot	94.27	10.62	384	872532	90722	109625661
Congestive hepatopathy	94.24	10.62	157	872759	5063	109711320
Angina unstable	94.23	10.62	315	872601	16117	109700266
Therapeutic response shortened	93.36	10.62	59	872857	29524	109686859
Disability	93.03	10.62	62	872854	30161	109686222
Nephrotic syndrome	92.91	10.62	280	872636	13551	109702832
Concomitant disease progression	92.80	10.62	128	872788	3482	109712901
Diastolic dysfunction	91.85	10.62	260	872656	12144	109704239
Pulmonary arterial pressure increased	90.95	10.62	153	872763	4974	109711409
Hepatorenal syndrome	90.78	10.62	144	872772	4453	109711930
Cholestasis	90.70	10.62	842	872074	63676	109652707
Visual impairment	90.68	10.62	654	872262	133774	109582609
Angina pectoris	90.62	10.62	819	872097	61476	109654907
Dilatation ventricular	89.38	10.62	134	872782	3941	109712442
Encephalopathy	89.18	10.62	1006	871910	80049	109636334
Thrombocytopenia	89.05	10.62	3482	869434	345403	109370980
Cardiac amyloidosis	87.49	10.62	110	872806	2727	109713656
Cardiorenal syndrome	87.36	10.62	91	872825	1827	109714556
Low cardiac output syndrome	86.54	10.62	71	872845	1035	109715348
Electrolyte imbalance	85.65	10.62	543	872373	36485	109679898
Drug use disorder	85.37	10.62	19	872897	18055	109698328
Hepatocellular carcinoma	85.12	10.62	219	872697	9661	109706722
Haematotoxicity	85.02	10.62	30	872886	21052	109695331
Dilatation atrial	84.97	10.62	127	872789	3725	109712658
Drug-induced liver injury	84.48	10.62	577	872339	119490	109596893
Vascular purpura	84.14	10.62	125	872791	3646	109712737
Normal newborn	83.56	10.62	34	872882	21862	109694521
Rash maculo-papular	83.39	10.62	925	871991	73297	109643086
Arteriosclerosis	83.33	10.62	402	872514	24365	109692018
Plasma cell myeloma	82.84	10.62	810	872106	62126	109654257
Agranulocytosis	82.83	10.62	798	872118	60962	109655421
Product dose omission issue	82.63	10.62	1921	870995	319861	109396522
Arteriosclerosis coronary artery	82.58	10.62	405	872511	24713	109691670
Hepatic function abnormal	82.00	10.62	1071	871845	88224	109628159
Oesophageal varices haemorrhage	81.72	10.62	143	872773	4802	109711581
Sinus node dysfunction	81.55	10.62	204	872712	8843	109707540
Schizophrenia	81.51	10.62	35	872881	21791	109694592
Osteoporosis	81.26	10.62	382	872534	86770	109629613
Weight increased	81.14	10.62	2608	870308	417036	109299347
Purpura	80.73	10.62	394	872522	23994	109692389
Therapy non-responder	80.72	10.62	822	872094	156485	109559898
Neutropenia	80.35	10.62	2296	870620	372324	109344059
Dyspnoea paroxysmal nocturnal	80.34	10.62	99	872817	2403	109713980
Aortic stenosis	79.97	10.62	256	872660	12803	109703580
Dermatitis exfoliative	79.34	10.62	233	872683	11114	109705269
Uveitis	79.21	10.62	36	872880	21674	109694709
Interstitial lung disease	79.03	10.62	1542	871374	137792	109578591
Dry eye	78.67	10.62	205	872711	55588	109660795
Diabetes mellitus inadequate control	78.66	10.62	452	872464	29323	109687060
Atrioventricular block first degree	78.32	10.62	269	872647	13956	109702427
Loss of personal independence in daily activities	78.19	10.62	781	872135	149239	109567144
Shock	78.19	10.62	705	872211	52883	109663500
Microcytic anaemia	78.16	10.62	160	872756	6058	109710325
Coagulopathy	77.99	10.62	572	872344	40339	109676044
Infective pulmonary exacerbation of cystic fibrosis	77.31	10.62	12	872904	14759	109701624
Device difficult to use	77.15	10.62	26	872890	18779	109697604
Platelet count decreased	77.09	10.62	2373	870543	228070	109488313
Infusion site reaction	76.93	10.62	22	872894	17660	109698723
Urinary tract discomfort	76.87	10.62	63	872853	917	109715466
Myopathy	76.80	10.62	395	872521	24565	109691818
Appendicitis	76.62	10.62	67	872849	28397	109687986
Circulatory collapse	76.26	10.62	591	872325	42402	109673981
Hypophagia	76.10	10.62	691	872225	51935	109664448
Cor pulmonale	75.65	10.62	92	872824	2202	109714181
Haematocrit decreased	75.20	10.62	826	872090	65291	109651092
Chronic sinusitis	75.16	10.62	53	872863	25031	109691352
Tenosynovitis	75.15	10.62	18	872898	16265	109700118
Intentional self-injury	74.82	10.62	112	872804	37317	109679066
Immune reconstitution inflammatory syndrome	74.76	10.62	18	872898	16208	109700175
Cardiac murmur	74.57	10.62	388	872528	24240	109692143
Ventricular arrhythmia	74.27	10.62	211	872705	9876	109706507
Disorientation	74.10	10.62	869	872047	69802	109646581
Muscle haemorrhage	73.97	10.62	166	872750	6703	109709680
Normochromic normocytic anaemia	73.72	10.62	249	872667	12808	109703575
Toxicity to various agents	73.46	10.62	3073	869843	477482	109238901
International normalised ratio abnormal	73.41	10.62	158	872758	6199	109710184
Vitamin B1 deficiency	73.25	10.62	61	872855	909	109715474
Liver disorder	73.10	10.62	743	872173	141500	109574883
Coronary arterial stent insertion	72.94	10.62	151	872765	5764	109710619
Hyponatraemic syndrome	72.72	10.62	56	872860	741	109715642
Pericardial haemorrhage	72.50	10.62	140	872776	5077	109711306
Urinary tract infection	72.01	10.62	3207	869709	323075	109393308
Hypertension	71.95	10.62	3291	869625	506793	109209590
Contusion	71.70	10.62	1353	871563	232008	109484375
Renal disorder	71.20	10.62	649	872267	48830	109667553
Ecchymosis	70.77	10.62	298	872618	17040	109699343
Occult blood positive	70.42	10.62	171	872745	7274	109709109
Haemorrhage	70.39	10.62	1209	871707	105483	109610900
Hypoalbuminaemia	69.58	10.62	429	872487	28545	109687838
Tachypnoea	69.02	10.62	540	872376	38855	109677528
Dyspnoea at rest	68.84	10.62	182	872734	8164	109708219
Myoclonus	68.51	10.62	471	872445	32527	109683856
Mental status changes	68.23	10.62	909	872007	75213	109641170
Blood parathyroid hormone decreased	67.68	10.62	11	872905	13078	109703305
Abdominal wall haematoma	67.27	10.62	143	872773	5562	109710821
Ventricular dysfunction	66.28	10.62	168	872748	7343	109709040
Pulmonary fibrosis	66.16	10.62	502	872414	101540	109614843
Female genital tract fistula	65.78	10.62	24	872892	16495	109699888
Hyperglycaemia	65.41	10.62	989	871927	84101	109632282
Injection site urticaria	65.26	10.62	27	872889	17188	109699195
Drug dose omission by device	65.15	10.62	17	872899	14499	109701884
Throat irritation	65.12	10.62	211	872705	53341	109663042
Gastric ulcer	64.93	10.62	537	872379	39290	109677093
Vaginal discharge	64.86	10.62	30	872886	17878	109698505
Heparin-induced thrombocytopenia	64.63	10.62	218	872698	11206	109705177
Ear pain	64.53	10.62	210	872706	53016	109663367
Injection site rash	64.41	10.62	54	872862	23365	109693018
Paraesthesia oral	64.21	10.62	104	872812	33567	109682816
Anticoagulation drug level above therapeutic	64.04	10.62	124	872792	4506	109711877
Lethargy	63.41	10.62	1065	871851	92511	109623872
Carotid artery thrombosis	63.38	10.62	3	872913	9635	109706748
Renal tubular necrosis	63.28	10.62	435	872481	30040	109686343
Gastritis erosive	62.67	10.62	223	872693	11777	109704606
Blood albumin decreased	62.41	10.62	403	872513	27249	109689134
Cardiac valve disease	62.36	10.62	149	872767	6272	109710111
Multiple-drug resistance	62.34	10.62	14	872902	13221	109703162
Mucosal inflammation	62.31	10.62	473	872443	95668	109620715
Cognitive disorder	61.90	10.62	1003	871913	86508	109629875
Subcutaneous haematoma	61.20	10.62	96	872820	2940	109713443
Vaginal flatulence	61.05	10.62	11	872905	12133	109704250
Progressive multifocal leukoencephalopathy	61.04	10.62	64	872852	24892	109691491
Serotonin syndrome	60.15	10.62	251	872665	58902	109657481
Right ventricular dysfunction	60.06	10.62	100	872816	3223	109713160
Pulmonary alveolar haemorrhage	60.01	10.62	316	872600	19834	109696549
Seronegative arthritis	59.97	10.62	15	872901	13162	109703221
Cardiac pacemaker insertion	59.89	10.62	145	872771	6156	109710227
Acute coronary syndrome	59.84	10.62	349	872567	22763	109693620
Joint destruction	59.35	10.62	8	872908	10935	109705448
Device issue	58.36	10.62	115	872801	34420	109681963
Troponin increased	58.36	10.62	419	872497	29347	109687036
Haemorrhage intracranial	58.09	10.62	410	872506	28559	109687824
Nodal rhythm	57.89	10.62	100	872816	3323	109713060
Exposure to toxic agent	57.82	10.62	15	872901	12843	109703540
Alveolar osteitis	57.72	10.62	56	872860	1029	109715354
Blood iron decreased	57.68	10.62	302	872614	18912	109697471
Neoplasm progression	57.39	10.62	288	872628	64307	109652076
Peritonitis bacterial	56.96	10.62	198	872718	10335	109706048
Troponin T increased	56.75	10.62	113	872803	4193	109712190
Cerebral haematoma	56.44	10.62	186	872730	9446	109706937
Oxygen consumption increased	56.38	10.62	133	872783	5552	109710831
Bundle branch block right	56.33	10.62	219	872697	12072	109704311
Blood glucose increased	55.99	10.62	1406	871510	131090	109585293
Ventricular fibrillation	55.99	10.62	535	872381	40778	109675605
Cerebral infarction	55.94	10.62	641	872275	51197	109665186
Left ventricular hypertrophy	55.91	10.62	230	872686	13014	109703369
Blood creatinine abnormal	55.38	10.62	135	872781	5757	109710626
Vomiting	55.25	10.62	6319	866597	904356	108812027
Oral herpes	55.24	10.62	127	872789	35953	109680430
Cutaneous vasculitis	54.48	10.62	222	872694	12507	109703876
Poisoning	54.47	10.62	91	872825	29014	109687369
Tachyarrhythmia	54.33	10.62	166	872750	8095	109708288
Varices oesophageal	54.17	10.62	152	872764	7063	109709320
Vascular graft	54.10	10.62	75	872841	2050	109714333
Catheter management	54.09	10.62	102	872814	3633	109712750
Drug tolerance	53.84	10.62	32	872884	16553	109699830
Tubulointerstitial nephritis	53.63	10.62	660	872256	53624	109662759
Coeliac disease	53.33	10.62	169	872747	43018	109673365
Ischaemic hepatitis	53.08	10.62	115	872801	4533	109711850
Colitis	52.77	10.62	534	872382	101789	109614594
Sputum culture positive	52.39	10.62	103	872813	3786	109712597
Neurologic neglect syndrome	52.37	10.62	6	872910	9292	109707091
Ankylosing spondylitis	52.28	10.62	29	872887	15583	109700800
Hypercapnia	52.10	10.62	200	872716	10959	109705424
Hypersensitivity vasculitis	51.95	10.62	146	872770	6791	109709592
Injection site warmth	51.85	10.62	37	872879	17368	109699015
Renal artery stenosis	51.80	10.62	100	872816	3626	109712757
Multiple drug therapy	51.74	10.62	160	872756	7854	109708529
Ammonia increased	51.68	10.62	163	872753	8087	109708296
Dermatitis bullous	51.58	10.62	274	872642	17255	109699128
Atrial enlargement	51.33	10.62	54	872862	1097	109715286
Paradoxical drug reaction	51.33	10.62	8	872908	9809	109706574
Cyanosis	51.18	10.62	406	872510	29335	109687048
Cytomegalovirus infection reactivation	50.76	10.62	42	872874	18291	109698092
Lung disorder	50.73	10.62	1059	871857	178988	109537395
Overlap syndrome	50.64	10.62	6	872910	9053	109707330
Vital capacity decreased	49.57	10.62	71	872845	2002	109714381
Pseudoporphyria	49.54	10.62	45	872871	758	109715625
Constipation	49.29	10.62	3367	869549	354419	109361964
Gouty arthritis	49.06	10.62	63	872853	1596	109714787
Cardiac tamponade	49.03	10.62	198	872718	11109	109705274
Staphylococcal sepsis	48.78	10.62	269	872647	17185	109699198
Nephrogenic anaemia	48.61	10.62	110	872806	4467	109711916
Chest pain	48.57	10.62	3523	869393	372852	109343531
Urinary retention	48.29	10.62	796	872120	68887	109647496
Post transplant lymphoproliferative disorder	48.10	10.62	32	872884	15581	109700802
Pulmonary vasculitis	48.08	10.62	137	872779	6423	109709960
Gastric ulcer haemorrhage	48.02	10.62	182	872734	9912	109706471
Hyperthyroidism	47.94	10.62	395	872521	28866	109687517
Retroperitoneal haematoma	47.85	10.62	131	872785	6000	109710383
Hypercalciuria	47.70	10.62	38	872878	530	109715853
Ventricular hypertrophy	47.68	10.62	143	872773	6902	109709481
Hepatotoxicity	47.46	10.62	299	872617	63101	109653282
Poor venous access	47.46	10.62	75	872841	24447	109691936
Alkalosis	47.45	10.62	44	872872	762	109715621
Acne	47.38	10.62	123	872793	33397	109682986
Device interaction	47.35	10.62	43	872873	724	109715659
Personality disorder	47.28	10.62	21	872895	12816	109703567
Gastrointestinal vascular malformation haemorrhagic	47.27	10.62	48	872868	934	109715449
Eye pain	47.05	10.62	219	872697	49880	109666503
Muscular weakness	46.59	10.62	1550	871366	246918	109469465
Duodenal ulcer haemorrhage	46.02	10.62	154	872762	7883	109708500
Adjustment disorder	45.93	10.62	14	872902	10781	109705602
Sleep disorder due to a general medical condition	45.92	10.62	233	872683	51879	109664504
Pathogen resistance	45.89	10.62	43	872873	17629	109698754
Long QT syndrome	45.85	10.62	142	872774	6976	109709407
Acidosis	45.83	10.62	320	872596	22211	109694172
Liver function test abnormal	45.72	10.62	782	872134	68168	109648215
Drug therapy	45.69	10.62	3	872913	7288	109709095
Endocarditis	45.68	10.62	218	872698	13153	109703230
Intra-abdominal haematoma	45.62	10.62	91	872825	3381	109713002
Hepatitis	45.60	10.62	472	872444	89582	109626801
Walking aid user	45.46	10.62	80	872836	24995	109691388
Proctitis	45.37	10.62	40	872876	16887	109699496
Dystonia	45.29	10.62	84	872832	25721	109690662
Panniculitis	45.28	10.62	34	872882	15548	109700835
Unintentional medical device removal	45.03	10.62	8	872908	8915	109707468
Blood creatine phosphokinase increased	44.96	10.62	819	872097	72258	109644125
Animal scratch	44.94	10.62	64	872852	1795	109714588
Basal cell carcinoma	44.85	10.62	194	872722	45076	109671307
Superinfection	44.84	10.62	123	872793	5640	109710743
Acute generalised exanthematous pustulosis	44.84	10.62	309	872607	21355	109695028
Aspartate aminotransferase increased	44.78	10.62	1613	871303	158323	109558060
Acute graft versus host disease	44.49	10.62	23	872893	12858	109703525
Polyomavirus-associated nephropathy	44.46	10.62	6	872910	8195	109708188
Condition aggravated	44.37	10.62	5100	867816	729736	108986647
Dermatitis exfoliative generalised	44.33	10.62	188	872728	10784	109705599
Affect lability	44.25	10.62	49	872867	18588	109697795
Emotional distress	44.19	10.62	545	872371	44302	109672081
Hypothermia	44.14	10.62	357	872559	25945	109690438
Gastrooesophageal reflux disease	44.07	10.62	1082	871834	178894	109537489
Acute graft versus host disease in skin	43.80	10.62	15	872901	10725	109705658
Pain in jaw	43.76	10.62	606	872310	50571	109665812
Irritability	43.72	10.62	211	872705	47598	109668785
Gouty tophus	43.71	10.62	34	872882	457	109715926
Stevens-Johnson syndrome	43.67	10.62	564	872352	46337	109670046
Gestational diabetes	43.61	10.62	4	872912	7385	109708998
Breast cancer stage I	43.59	10.62	4	872912	7383	109709000
Blood pressure diastolic abnormal	43.59	10.62	86	872830	25729	109690654
Substance abuse	43.43	10.62	22	872894	12441	109703942
Clostridium difficile colitis	43.13	10.62	532	872384	43246	109673137
Wound secretion	42.91	10.62	136	872780	6765	109709618
Right ventricular hypertrophy	42.77	10.62	60	872856	1659	109714724
Left ventricular enlargement	42.71	10.62	43	872873	828	109715555
Tunnel vision	42.41	10.62	65	872851	1950	109714433
Myasthenia gravis	42.39	10.62	65	872851	21446	109694937
Atrial thrombosis	42.37	10.62	101	872815	4245	109712138
Hypercreatininaemia	42.36	10.62	52	872864	1257	109715126
Lymphoedema	42.33	10.62	231	872685	14698	109701685
Ovarian cyst	42.31	10.62	29	872887	13901	109702482
Cardiopulmonary failure	42.25	10.62	148	872768	7755	109708628
Intercepted product preparation error	42.17	10.62	3	872913	6817	109709566
Left ventricular dilatation	42.05	10.62	54	872862	1368	109715015
Hepatic cancer	41.90	10.62	187	872729	10969	109705414
Asterixis	41.77	10.62	83	872833	3075	109713308
Drug level increased	41.59	10.62	567	872349	47152	109669231
Neuropathy peripheral	41.43	10.62	1087	871829	178190	109538193
Coagulation time prolonged	41.42	10.62	79	872837	2838	109713545
Metabolic encephalopathy	41.24	10.62	185	872731	10875	109705508
Localised oedema	41.19	10.62	163	872753	9060	109707323
Hypocoagulable state	41.13	10.62	74	872842	2541	109713842
Blood sodium increased	41.12	10.62	116	872800	5407	109710976
Petechiae	41.06	10.62	320	872596	22997	109693386
Left atrial enlargement	40.97	10.62	59	872857	1672	109714711
Haematoma muscle	40.91	10.62	96	872820	3994	109712389
Poisoning deliberate	40.87	10.62	92	872824	26239	109690144
Fear of injection	40.83	10.62	10	872906	8901	109707482
Left ventricle outflow tract obstruction	40.70	10.62	34	872882	509	109715874
Dermatitis atopic	40.66	10.62	88	872828	25453	109690930
Peripartum cardiomyopathy	40.63	10.62	23	872893	173	109716210
Sudden cardiac death	40.61	10.62	117	872799	5520	109710863
Eye irritation	40.54	10.62	132	872784	33320	109683063
Extrasystoles	40.42	10.62	151	872765	8167	109708216
BK virus infection	40.19	10.62	27	872889	13079	109703304
Maternal exposure before pregnancy	40.15	10.62	5	872911	7260	109709123
Muscle twitching	39.94	10.62	113	872803	29822	109686561
Ventricular hypokinesia	39.90	10.62	185	872731	11029	109705354
Product storage error	39.69	10.62	69	872847	21659	109694724
Uterine perforation	39.58	10.62	4	872912	6836	109709547
Spontaneous haematoma	39.52	10.62	62	872854	1899	109714484
Disseminated intravascular coagulation	39.51	10.62	499	872417	40787	109675596
Nephrosclerosis	39.49	10.62	63	872853	1958	109714425
Dizziness postural	39.39	10.62	223	872693	14386	109701997
Syringe issue	39.37	10.62	13	872903	9512	109706871
Haemorrhage subcutaneous	38.98	10.62	114	872802	5425	109710958
Hypoacusis	38.81	10.62	437	872479	34754	109681629
Mitral valve disease	38.27	10.62	84	872832	3341	109713042
Multiple sclerosis	38.11	10.62	92	872824	25606	109690777
Prostate cancer	38.09	10.62	160	872756	37481	109678902
Paracentesis	38.05	10.62	51	872865	1349	109715034
Diabetic nephropathy	38.03	10.62	85	872831	3423	109712960
Intestinal haemorrhage	37.98	10.62	136	872780	7205	109709178
Haemophagocytic lymphohistiocytosis	37.92	10.62	125	872791	31434	109684949
Subdural haemorrhage	37.86	10.62	126	872790	6432	109709951
Pulmonary arterial pressure abnormal	37.75	10.62	42	872874	911	109715472
Oropharyngeal pain	37.71	10.62	797	872119	134479	109581904
Macular degeneration	37.58	10.62	71	872845	21588	109694795
Abdominal cavity drainage	37.56	10.62	41	872875	870	109715513
Disease recurrence	37.54	10.62	303	872613	60481	109655902
Malignant neoplasm progression	37.35	10.62	1070	871846	173497	109542886
Drug effective for unapproved indication	37.35	10.62	34	872882	14133	109702250
Neuralgia	37.13	10.62	227	872689	48251	109668132
Haemorrhagic diathesis	37.07	10.62	137	872779	7371	109709012
Catheter site infection	37.04	10.62	143	872773	7857	109708526
Right-to-left cardiac shunt	36.78	10.62	26	872890	299	109716084
Blood pressure inadequately controlled	36.62	10.62	138	872778	7495	109708888
Epstein-Barr virus infection	36.56	10.62	57	872859	18681	109697702
Device use error	36.54	10.62	13	872903	9076	109707307
Aspiration pleural cavity	36.51	10.62	56	872860	1681	109714702
Blood pressure fluctuation	36.33	10.62	396	872520	74428	109641955
Altered state of consciousness	36.21	10.62	648	872268	56978	109659405
Blood glucose decreased	36.14	10.62	374	872542	29114	109687269
Aplastic anaemia	36.07	10.62	321	872595	23987	109692396
Tendonitis	35.89	10.62	97	872819	25986	109690397
Prothrombin time shortened	35.84	10.62	85	872831	3561	109712822
Alkalosis hypochloraemic	35.75	10.62	33	872883	568	109715815
Hypertensive heart disease	35.67	10.62	98	872818	4498	109711885
Diffuse large B-cell lymphoma recurrent	35.64	10.62	4	872912	6295	109710088
Limb injury	35.64	10.62	454	872462	37182	109679201
Abdominal pain	35.52	10.62	3526	869390	509463	109206920
Red blood cell count decreased	35.50	10.62	724	872192	65199	109651184
Pustular psoriasis	35.45	10.62	33	872883	13572	109702811
Lymphoid tissue hypoplasia	35.45	10.62	54	872862	1611	109714772
Photophobia	35.34	10.62	96	872820	25675	109690708
Peripheral arterial occlusive disease	35.19	10.62	156	872760	9124	109707259
Blood chloride decreased	35.15	10.62	154	872762	8961	109707422
Scrotal oedema	35.06	10.62	54	872862	1627	109714756
Mitral valve stenosis	34.98	10.62	49	872867	1353	109715030
Cataract	34.97	10.62	430	872486	79055	109637328
Catheterisation cardiac	34.90	10.62	118	872798	6073	109710310
Catheter site haemorrhage	34.86	10.62	114	872802	5766	109710617
Anti-neutrophil cytoplasmic antibody positive vasculitis	34.83	10.62	108	872808	5309	109711074
Radiculopathy	34.78	10.62	62	872854	19274	109697109
Acrodermatitis enteropathica	34.65	10.62	9	872907	0	109716383
Lung transplant	34.56	10.62	106	872810	5180	109711203
Confusional state	34.52	10.62	4215	868701	464465	109251918
Coronary artery occlusion	34.46	10.62	228	872688	15544	109700839
Mood swings	34.36	10.62	81	872835	22731	109693652
Hyperbilirubinaemia	34.33	10.62	382	872534	30289	109686094
Neuroleptic malignant syndrome	34.33	10.62	145	872771	33914	109682469
Cytomegalovirus infection	34.27	10.62	270	872646	54174	109662209
Decubitus ulcer	34.20	10.62	254	872662	17982	109698401
Neuromyopathy	34.13	10.62	55	872861	1724	109714659
Chronic respiratory failure	34.13	10.62	87	872829	3816	109712567
Illness	34.12	10.62	450	872466	81721	109634662
Bronchitis	34.06	10.62	1541	871375	155491	109560892
Aortic valve stenosis	34.02	10.62	119	872797	6231	109710152
Nephropathy	33.99	10.62	202	872714	13265	109703118
Total lung capacity abnormal	33.87	10.62	96	872820	4487	109711896
Hypokinesia	33.83	10.62	291	872625	21535	109694848
Thymus hypoplasia	33.53	10.62	53	872863	1634	109714749
Juvenile idiopathic arthritis	33.53	10.62	4	872912	6003	109710380
Ear congestion	33.41	10.62	83	872833	3582	109712801
Duodenal ulcer	33.37	10.62	266	872650	19248	109697135
Multimorbidity	33.36	10.62	50	872866	1470	109714913
Catheter placement	33.28	10.62	78	872838	3242	109713141
Ventricular internal diameter abnormal	33.27	10.62	22	872894	225	109716158
Ventricular dyssynchrony	33.24	10.62	16	872900	82	109716301
Bronchial secretion retention	33.08	10.62	101	872815	4923	109711460
Haemorrhagic stroke	33.01	10.62	204	872712	13585	109702798
Hypercreatinaemia	32.94	10.62	27	872889	393	109715990
Tumour lysis syndrome	32.84	10.62	380	872536	30421	109685962
Breast cancer female	32.78	10.62	30	872886	12438	109703945
Hypomania	32.72	10.62	20	872896	10190	109706193
Local anaesthetic systemic toxicity	32.67	10.62	3	872913	5534	109710849
Protein total decreased	32.58	10.62	171	872745	10719	109705664
Device dislocation	32.56	10.62	134	872782	31570	109684813
Tongue oedema	32.23	10.62	140	872776	8116	109708267
Haemorrhoidal haemorrhage	32.18	10.62	138	872778	7955	109708428
Right atrial dilatation	32.17	10.62	40	872876	980	109715403
Neutrophil count decreased	32.14	10.62	718	872198	120223	109596160
Blood lactic acid	31.90	10.62	28	872888	450	109715933
Antibiotic level above therapeutic	31.77	10.62	40	872876	993	109715390
Erysipelas	31.71	10.62	195	872721	12963	109703420
Paranoia	31.70	10.62	82	872834	22292	109694091
Pneumonia aspiration	31.69	10.62	853	872063	80380	109636003
Change of bowel habit	31.64	10.62	70	872846	2799	109713584
Blood pressure systolic decreased	31.64	10.62	198	872718	13243	109703140
Eye pruritus	31.53	10.62	142	872774	32633	109683750
Pulmonary veno-occlusive disease	31.53	10.62	59	872857	2089	109714294
Sinus arrest	31.49	10.62	89	872827	4153	109712230
Inflammatory bowel disease	31.47	10.62	9	872907	7225	109709158
Sexual dysfunction	31.34	10.62	14	872902	8516	109707867
Electrocardiogram ST segment abnormal	31.31	10.62	53	872863	1732	109714651
Portal hypertensive gastropathy	31.30	10.62	55	872861	1853	109714530
Delayed graft function	31.30	10.62	89	872827	4168	109712215
Mitral valve calcification	31.23	10.62	52	872864	1676	109714707
Mucormycosis	31.13	10.62	23	872893	10605	109705778
Chronic hepatic failure	31.08	10.62	44	872872	1227	109715156
Catheter site pruritus	30.97	10.62	61	872855	2245	109714138
Gamma-glutamyltransferase increased	30.96	10.62	667	872249	60642	109655741
Pulmonary hypertensive crisis	30.96	10.62	27	872889	430	109715953
Brain natriuretic peptide abnormal	30.90	10.62	37	872879	871	109715512
Generalised tonic-clonic seizure	30.89	10.62	279	872637	54401	109661982
Pulmonary haemorrhage	30.75	10.62	229	872687	16227	109700156
Drug specific antibody present	30.75	10.62	14	872902	8420	109707963
Scleroderma	30.72	10.62	115	872801	6226	109710157
Diverticulum	30.70	10.62	219	872697	15307	109701076
Total lung capacity decreased	30.68	10.62	9	872907	7105	109709278
Spinal fusion surgery	30.67	10.62	17	872899	9139	109707244
Renal ischaemia	30.66	10.62	61	872855	2262	109714121
Injection site mass	30.61	10.62	96	872820	24517	109691866
Gastrointestinal angiodysplasia	30.49	10.62	43	872873	1195	109715188
Hyperparathyroidism secondary	30.31	10.62	75	872841	3229	109713154
Complication of device insertion	30.20	10.62	16	872900	8822	109707561
Neuritis	30.06	10.62	127	872789	7272	109709111
Amyloidosis	30.02	10.62	73	872843	3108	109713275
Reversible airways obstruction	29.88	10.62	63	872853	2436	109713947
Ear pruritus	29.85	10.62	10	872906	7250	109709133
Drug withdrawal syndrome	29.77	10.62	177	872739	37877	109678506
Inability to afford medication	29.75	10.62	85	872831	3991	109712392
Pelvic pain	29.69	10.62	50	872866	15892	109700491
Eosinophil count increased	29.68	10.62	275	872641	20783	109695600
Chronic graft versus host disease	29.65	10.62	19	872897	9438	109706945
Nodal arrhythmia	29.61	10.62	58	872858	2126	109714257
Nephrogenic systemic fibrosis	29.59	10.62	103	872813	5380	109711003
Pancreatitis acute	29.56	10.62	653	872263	59621	109656762
Continuous haemodiafiltration	29.47	10.62	54	872862	1881	109714502
Nocturnal dyspnoea	29.41	10.62	53	872863	1822	109714561
Sneezing	29.34	10.62	141	872775	31843	109684540
Dementia	29.12	10.62	380	872536	31293	109685090
Supraventricular tachycardia	29.11	10.62	308	872608	24114	109692269
Mitral valve replacement	29.05	10.62	30	872886	596	109715787
Ocular hyperaemia	29.03	10.62	186	872730	39100	109677283
Activated partial thromboplastin time prolonged	29.00	10.62	287	872629	22081	109694302
Alanine aminotransferase abnormal	28.93	10.62	19	872897	9315	109707068
Anticoagulant therapy	28.88	10.62	4	872912	5357	109711026
Ovarian hyperstimulation syndrome	28.87	10.62	4	872912	5356	109711027
Central nervous system lesion	28.76	10.62	49	872867	15504	109700879
Peripheral vascular disorder	28.71	10.62	139	872777	8437	109707946
Heart sounds abnormal	28.68	10.62	46	872870	1436	109714947
Post procedural haematoma	28.67	10.62	64	872852	2575	109713808
Exposure via skin contact	28.62	10.62	37	872879	13110	109703273
Medication error	28.60	10.62	1059	871857	104307	109612076
Hypothyroidism	28.58	10.62	766	872150	72133	109644250
Anticoagulation drug level increased	28.50	10.62	37	872879	948	109715435
Cardiac operation	28.44	10.62	108	872808	5887	109710496
Extrapyramidal disorder	28.42	10.62	124	872792	28743	109687640
Right ventricular dilatation	28.34	10.62	60	872856	2327	109714056
Amenorrhoea	28.33	10.62	19	872897	9212	109707171
Anosmia	28.30	10.62	34	872882	12438	109703945
Cardioversion	28.29	10.62	59	872857	2264	109714119
Walking distance test abnormal	28.06	10.62	32	872884	714	109715669
Embolic stroke	28.05	10.62	140	872776	8603	109707780
Polyarthritis	28.03	10.62	68	872848	18895	109697488
Ulcer	27.99	10.62	212	872704	42904	109673479
Hypoperfusion	27.91	10.62	71	872845	3110	109713273
Device pacing issue	27.88	10.62	17	872899	149	109716234
Cardiac cirrhosis	27.83	10.62	21	872895	269	109716114
Lymphadenopathy	27.83	10.62	346	872570	63489	109652894
Injection site haemorrhage	27.80	10.62	150	872766	32878	109683505
Blood potassium abnormal	27.77	10.62	82	872834	3923	109712460
Catheter site discharge	27.73	10.62	68	872848	2911	109713472
Product prescribing error	27.73	10.62	564	872352	50767	109665616
Transplant evaluation	27.68	10.62	51	872865	1784	109714599
Influenza like illness	27.63	10.62	511	872405	87901	109628482
Diabetic foot	27.60	10.62	83	872833	4012	109712371
Hypochromasia	27.56	10.62	31	872885	681	109715702
Chronic left ventricular failure	27.55	10.62	42	872874	1254	109715129
Wound complication	27.45	10.62	109	872807	6068	109710315
Haemodynamic instability	27.44	10.62	289	872627	22599	109693784
Acute respiratory distress syndrome	27.26	10.62	580	872336	52618	109663765
Gastric haemorrhage	27.24	10.62	217	872699	15698	109700685
Nasal oedema	27.12	10.62	10	872906	6829	109709554
Implantable defibrillator insertion	27.12	10.62	40	872876	1159	109715224
Scleritis	27.05	10.62	5	872911	5415	109710968
Gastric varices	26.98	10.62	34	872882	845	109715538
Therapeutic embolisation	26.88	10.62	28	872888	562	109715821
Scrotal swelling	26.82	10.62	40	872876	1171	109715212
Graft versus host disease in gastrointestinal tract	26.80	10.62	19	872897	8949	109707434
Neutropenic sepsis	26.79	10.62	138	872778	30608	109685775
Pickwickian syndrome	26.77	10.62	27	872889	521	109715862
Disturbance in social behaviour	26.72	10.62	4	872912	5054	109711329
Spondylitis	26.71	10.62	30	872886	11308	109705075
Blood lactate dehydrogenase increased	26.62	10.62	495	872421	43839	109672544
Volume blood decreased	26.58	10.62	24	872892	401	109715982
Systemic infection	26.57	10.62	23	872893	9796	109706587
Blood urea abnormal	26.53	10.62	51	872865	1843	109714540
Hepatitis B reactivation	26.40	10.62	13	872903	7471	109708912
Akathisia	26.39	10.62	60	872856	17053	109699330
Musculoskeletal disorder	26.39	10.62	91	872825	22573	109693810
Faecal calprotectin increased	26.35	10.62	10	872906	6709	109709674
Product dose omission in error	26.31	10.62	96	872820	23416	109692967
Sinus arrhythmia	26.29	10.62	55	872861	2115	109714268
Right atrial enlargement	26.27	10.62	26	872890	490	109715893
Breast cancer	26.23	10.62	187	872729	38355	109678028
Hypertensive crisis	26.13	10.62	301	872615	24071	109692312
General symptom	26.10	10.62	19	872897	8827	109707556
Bladder pain	26.08	10.62	64	872852	2741	109713642
Hallucination	25.99	10.62	1013	871903	100419	109615964
Ventricular hyperkinesia	25.95	10.62	21	872895	300	109716083
Labelled drug-drug interaction medication error	25.88	10.62	349	872567	28953	109687430
Uraemic encephalopathy	25.87	10.62	32	872884	780	109715603
Bundle branch block	25.81	10.62	49	872867	1754	109714629
Anaphylactic shock	25.75	10.62	271	872645	51275	109665108
Rhinorrhoea	25.73	10.62	615	872301	102051	109614332
Erythromelalgia	25.73	10.62	24	872892	419	109715964
Gastrointestinal toxicity	25.71	10.62	30	872886	11118	109705265
Coordination abnormal	25.68	10.62	107	872809	25121	109691262
Alveolar lung disease	25.63	10.62	30	872886	689	109715694
Mitral valve thickening	25.62	10.62	31	872885	738	109715645
Wound haemorrhage	25.56	10.62	89	872827	4649	109711734
Heart transplant	25.51	10.62	46	872870	1582	109714801
Diabetic metabolic decompensation	25.44	10.62	78	872838	3811	109712572
Abnormal loss of weight	25.34	10.62	153	872763	10104	109706279
Angiotensin converting enzyme inhibitor foetopathy	25.12	10.62	10	872906	29	109716354
Graft versus host disease	25.08	10.62	71	872845	18735	109697648
Oxygen therapy	25.06	10.62	81	872835	4072	109712311
Blood bicarbonate increased	25.04	10.62	42	872874	1362	109715021
Haemolytic anaemia	25.01	10.62	264	872652	20656	109695727
Drug dependence	24.98	10.62	263	872653	49757	109666626
Obstructive airways disorder	24.90	10.62	507	872409	45642	109670741
Normocytic anaemia	24.74	10.62	109	872807	6358	109710025
Device related infection	24.69	10.62	444	872472	39075	109677308
Tooth infection	24.67	10.62	91	872825	22125	109694258
Emotional disorder	24.65	10.62	57	872859	16103	109700280
Disseminated aspergillosis	24.57	10.62	58	872858	2422	109713961
Melanoderma	24.52	10.62	24	872892	446	109715937
Abdominal wall haemorrhage	24.51	10.62	30	872886	723	109715660
Mycobacterial infection	24.51	10.62	3	872913	4414	109711969
Infected skin ulcer	24.50	10.62	78	872838	3889	109712494
Blood sodium abnormal	24.46	10.62	41	872875	1329	109715054
Electrocardiogram T wave peaked	24.46	10.62	38	872878	1154	109715229
Hypocholesterolaemia	24.45	10.62	10	872906	6411	109709972
Atrial septal defect repair	24.40	10.62	25	872891	492	109715891
Supraventricular extrasystoles	24.31	10.62	127	872789	7946	109708437
Second primary malignancy	24.26	10.62	68	872848	18000	109698383
Stasis dermatitis	24.23	10.62	48	872868	1774	109714609
Heart disease congenital	24.23	10.62	28	872888	634	109715749
Haemorrhoids	24.16	10.62	406	872510	35266	109681117
Atrioventricular block second degree	24.16	10.62	128	872788	8053	109708330
Bone density decreased	24.13	10.62	57	872859	15985	109700398
Catheter site erythema	24.13	10.62	103	872813	5925	109710458
Brain scan abnormal	24.13	10.62	44	872872	1527	109714856
Anal abscess	24.07	10.62	34	872882	11604	109704779
Throat tightness	24.02	10.62	160	872756	33329	109683054
Tardive dyskinesia	24.01	10.62	44	872872	13535	109702848
Anal fistula	23.97	10.62	19	872897	8454	109707929
Hepatitis fulminant	23.97	10.62	132	872784	8428	109707955
Cirrhosis alcoholic	23.91	10.62	36	872880	1063	109715320
Subarachnoid haemorrhage	23.91	10.62	348	872568	29354	109687029
Hyperprolactinaemia	23.83	10.62	11	872905	6564	109709819
Urosepsis	23.75	10.62	357	872559	30318	109686065
Ischaemic contracture of the left ventricle	23.73	10.62	15	872901	141	109716242
Mouth haemorrhage	23.69	10.62	185	872731	13303	109703080
Cardiac ablation	23.68	10.62	60	872856	2622	109713761
Hospice care	23.55	10.62	174	872742	12299	109704084
Feeling cold	23.46	10.62	388	872528	33599	109682784
Hip fracture	23.42	10.62	399	872517	34752	109681631
Prohormone brain natriuretic peptide increased	23.36	10.62	22	872894	389	109715994
Rectal prolapse	23.32	10.62	58	872858	2505	109713878
Myoglobin blood increased	23.27	10.62	80	872836	4152	109712231
Demyelination	23.27	10.62	24	872892	9405	109706978
Hiatus hernia	23.24	10.62	326	872590	27280	109689103
Cardiac hypertrophy	23.19	10.62	49	872867	1898	109714485
Pulmonary vein stenosis	23.13	10.62	15	872901	148	109716235
Oedema due to renal disease	23.10	10.62	6	872910	0	109716383
Eosinophilic granulomatosis with polyangiitis	23.06	10.62	154	872762	10532	109705851
Glomerular filtration rate	23.00	10.62	16	872900	179	109716204
Joint effusion	22.97	10.62	86	872830	20819	109695564
Cardiac death	22.94	10.62	45	872871	1651	109714732
Renal artery thrombosis	22.92	10.62	25	872891	530	109715853
Lung infiltration	22.86	10.62	296	872620	24332	109692051
Hepatic hydrothorax	22.83	10.62	13	872903	99	109716284
Peritonitis	22.78	10.62	373	872543	32234	109684149
Haemoconcentration	22.78	10.62	17	872899	214	109716169
Graft versus host disease in skin	22.74	10.62	19	872897	8235	109708148
Gastric polyps	22.60	10.62	95	872821	5428	109710955
Priapism	22.53	10.62	9	872907	5852	109710531
Cardiovascular insufficiency	22.50	10.62	67	872849	3221	109713162
Leukocytosis	22.37	10.62	570	872346	53258	109663125
Soft tissue mass	22.37	10.62	42	872874	1491	109714892
Human herpesvirus 6 infection	22.36	10.62	12	872904	6569	109709814
Seizure	22.24	10.62	1475	871441	219710	109496673
Pharyngitis	22.24	10.62	112	872804	24986	109691397
Accidental death	22.23	10.62	6	872910	5003	109711380
Hyperglycaemic hyperosmolar nonketotic syndrome	22.21	10.62	63	872853	2946	109713437
Hypocalvaria	22.16	10.62	10	872906	43	109716340
Crystalluria	22.15	10.62	39	872877	1316	109715067
Hallucination, auditory	22.15	10.62	120	872796	26277	109690106
Ureteric rupture	22.15	10.62	7	872909	7	109716376
Aortic aneurysm	22.14	10.62	144	872772	9760	109706623
Menstruation irregular	22.12	10.62	9	872907	5788	109710595
Epstein-Barr virus infection reactivation	22.11	10.62	3	872913	4081	109712302
Infection reactivation	22.09	10.62	3	872913	4078	109712305
Anosognosia	22.04	10.62	3	872913	4071	109712312
Haemorrhagic disorder	22.02	10.62	46	872870	1767	109714616
Left atrial dilatation	21.99	10.62	70	872846	3490	109712893
Pancytopenia	21.95	10.62	1931	870985	207682	109508701
Mental disorder	21.88	10.62	198	872718	38593	109677790
Peripheral ischaemia	21.87	10.62	156	872760	10902	109705481
Sensory loss	21.84	10.62	91	872825	21366	109695017
Aortic valve replacement	21.83	10.62	43	872873	1583	109714800
Glomerular filtration rate abnormal	21.76	10.62	54	872862	2329	109714054
Pallor	21.75	10.62	592	872324	55875	109660508
Depressed mood	21.74	10.62	343	872573	60466	109655917
Upper respiratory tract infection	21.70	10.62	832	872084	130496	109585887
Intestinal ischaemia	21.66	10.62	209	872707	15970	109700413
Right atrial hypertrophy	21.64	10.62	27	872889	664	109715719
Right ventricular enlargement	21.58	10.62	33	872883	988	109715395
Gastrointestinal arteriovenous malformation	21.55	10.62	32	872884	933	109715450
Aggression	21.50	10.62	333	872583	58877	109657506
Cytokine release syndrome	21.46	10.62	408	872508	69898	109646485
Haemothorax	21.44	10.62	111	872805	6920	109709463
Electrocardiogram repolarisation abnormality	21.41	10.62	53	872863	2282	109714101
Electrocardiogram abnormal	21.39	10.62	234	872682	18475	109697908
Pain in extremity	21.33	10.62	3448	869468	483670	109232713
Hepatitis C	21.29	10.62	171	872745	12402	109703981
Acute myeloid leukaemia recurrent	21.27	10.62	7	872909	5132	109711251
Hydrothorax	21.24	10.62	43	872873	1615	109714768
Crying	21.23	10.62	117	872799	25511	109690872
Urine output increased	21.22	10.62	59	872857	2727	109713656
Hypertrophic cardiomyopathy	21.21	10.62	64	872852	3099	109713284
Idiopathic pulmonary fibrosis	21.20	10.62	87	872829	4917	109711466
Renal function test abnormal	21.19	10.62	132	872784	8814	109707569
Hyperaldosteronism	21.17	10.62	26	872890	629	109715754
Synovial cyst	21.15	10.62	36	872880	11394	109704989
Palpitations	21.14	10.62	1494	871422	157718	109558665
Dysuria	21.13	10.62	624	872292	59607	109656776
Product administration error	21.13	10.62	412	872504	36805	109679578
Blood chloride increased	21.13	10.62	103	872813	6269	109710114
Transferrin saturation decreased	21.11	10.62	38	872878	1305	109715078
Renal cyst haemorrhage	21.11	10.62	28	872888	733	109715650
Device deployment issue	21.06	10.62	4	872912	4249	109712134
Hepatomegaly	20.99	10.62	260	872656	21154	109695229
Withdrawal syndrome	20.99	10.62	153	872763	31227	109685156
Colitis microscopic	20.98	10.62	179	872737	13215	109703168
Heavy menstrual bleeding	20.94	10.62	63	872853	16302	109700081
Injection site induration	20.93	10.62	36	872880	11347	109705036
Haemorrhagic transformation stroke	20.89	10.62	62	872854	2975	109713408
Thrombocytopenic purpura	20.86	10.62	62	872854	2977	109713406
Penis injury	20.85	10.62	13	872903	119	109716264
Pregnancy with contraceptive device	20.85	10.62	3	872913	3904	109712479
Mite allergy	20.84	10.62	96	872820	5707	109710676
Skin haemorrhage	20.76	10.62	113	872803	24714	109691669
Hyperlactacidaemia	20.73	10.62	124	872792	8162	109708221
Lymphoproliferative disorder	20.66	10.62	16	872900	7202	109709181
Marasmus	20.65	10.62	43	872873	1648	109714735
Reversible cerebral vasoconstriction syndrome	20.57	10.62	6	872910	4755	109711628
Haemarthrosis	20.51	10.62	113	872803	7216	109709167
Hypertransaminasaemia	20.50	10.62	110	872806	24145	109692238
Internal haemorrhage	20.46	10.62	143	872773	9928	109706455
Right ventricular systolic pressure increased	20.44	10.62	33	872883	1036	109715347
Crepitations	20.37	10.62	151	872765	10684	109705699
Hypoproteinaemia	20.36	10.62	97	872819	5848	109710535
Paroxysmal arrhythmia	20.36	10.62	10	872906	54	109716329
Gastric antral vascular ectasia	20.28	10.62	35	872881	1162	109715221
Ischaemia	20.27	10.62	132	872784	8951	109707432
Intestinal stenosis	20.27	10.62	6	872910	4709	109711674
Alveolitis	20.27	10.62	79	872837	4360	109712023
Peritoneal dialysis	20.22	10.62	30	872886	874	109715509
Nephropathy toxic	20.20	10.62	317	872599	27161	109689222
Viral mutation identified	20.17	10.62	5	872911	4414	109711969
Humerus fracture	20.16	10.62	150	872766	10626	109705757
Pharyngitis streptococcal	20.11	10.62	47	872869	13230	109703153
Drug monitoring procedure not performed	20.11	10.62	37	872879	1293	109715090
Post procedural haemorrhage	20.09	10.62	199	872717	15313	109701070
Pancreatitis	20.08	10.62	573	872343	92960	109623423
Essential hypertension	20.00	10.62	118	872798	7729	109708654
Eye injury	19.99	10.62	19	872897	7736	109708647
Enuresis	19.97	10.62	4	872912	4092	109712291
Facial bones fracture	19.95	10.62	85	872831	4886	109711497
Transplant rejection	19.90	10.62	113	872803	24454	109691929
Hypochromic anaemia	19.83	10.62	63	872853	3138	109713245
Arrhythmia supraventricular	19.83	10.62	53	872863	2393	109713990
Chromaturia	19.83	10.62	334	872582	29026	109687357
Acute left ventricular failure	19.82	10.62	51	872865	2250	109714133
Blood pressure systolic abnormal	19.75	10.62	115	872801	24735	109691648
Mood altered	19.74	10.62	94	872822	21281	109695102
Arteriovenous malformation	19.74	10.62	46	872870	1905	109714478
Myxoedema coma	19.74	10.62	26	872890	676	109715707
Craniocerebral injury	19.73	10.62	96	872820	5838	109710545
Diabetic neuropathy	19.64	10.62	108	872808	6891	109709492
Portal hypertension	19.57	10.62	126	872790	8511	109707872
Diverticulum intestinal haemorrhagic	19.54	10.62	82	872834	4681	109711702
Hepatorenal failure	19.52	10.62	37	872879	1323	109715060
Cardioactive drug level above therapeutic	19.52	10.62	16	872900	233	109716150
Carbon dioxide increased	19.50	10.62	58	872858	2786	109713597
Creatinine urine decreased	19.50	10.62	19	872897	351	109716032
Cystitis haemorrhagic	19.49	10.62	42	872874	12167	109704216
Product preparation error	19.46	10.62	35	872881	10844	109705539
Sleep apnoea syndrome	19.45	10.62	437	872479	40010	109676373
Diplopia	19.44	10.62	224	872692	41670	109674713
Angioplasty	19.43	10.62	46	872870	1925	109714458
Foetal death	19.43	10.62	203	872713	15842	109700541
Strangury	19.40	10.62	16	872900	235	109716148
Lymphocyte stimulation test positive	19.38	10.62	32	872884	1024	109715359
Granuloma	19.36	10.62	28	872888	9462	109706921
Wrong patient	19.35	10.62	39	872877	1460	109714923
Hyperaesthesia	19.35	10.62	56	872860	14671	109701712
Drug level decreased	19.29	10.62	78	872838	18470	109697913
Left ventricular end-diastolic pressure increased	19.28	10.62	26	872890	692	109715691
Skin toxicity	19.26	10.62	40	872876	11743	109704640
Respiratory acidosis	19.21	10.62	180	872736	13646	109702737
Underdose	19.03	10.62	370	872546	63184	109653199
Accidental overdose	19.01	10.62	540	872376	51294	109665089
Right ventricular systolic pressure decreased	18.97	10.62	12	872904	113	109716270
Dizziness	18.96	10.62	5973	866943	692220	109024163
Optic neuritis	18.94	10.62	37	872879	11110	109705273
Coma hepatic	18.92	10.62	32	872884	1045	109715338
Immune-mediated enterocolitis	18.92	10.62	32	872884	10153	109706230
Disturbance in attention	18.85	10.62	360	872556	61635	109654748
Diabetic hyperosmolar coma	18.85	10.62	29	872887	873	109715510
Heart valve incompetence	18.84	10.62	72	872844	3937	109712446
Impaired quality of life	18.83	10.62	149	872767	29868	109686515
Aortic valve disease	18.81	10.62	49	872867	2178	109714205
Bilirubin conjugated increased	18.80	10.62	98	872818	6126	109710257
Urine calcium decreased	18.77	10.62	8	872908	29	109716354
Degenerative aortic valve disease	18.72	10.62	15	872901	211	109716172
Portopulmonary hypertension	18.72	10.62	13	872903	145	109716238
Retroperitoneal haemorrhage	18.67	10.62	96	872820	5969	109710414
Malnutrition	18.67	10.62	311	872605	26968	109689415
Sickle cell anaemia with crisis	18.66	10.62	29	872887	9516	109706867
Foetal exposure during pregnancy	18.63	10.62	19	872897	7486	109708897
Histoplasmosis disseminated	18.62	10.62	4	872912	3895	109712488
Mucous stools	18.57	10.62	16	872900	6831	109709552
Impaired work ability	18.56	10.62	127	872789	26292	109690091
Hypoglobulinaemia	18.55	10.62	15	872901	214	109716169
Aortic dilatation	18.55	10.62	49	872867	2197	109714186
Nocardiosis	18.53	10.62	19	872897	7467	109708916
Phlebitis deep	18.46	10.62	7	872909	17	109716366
Cardiac ventricular disorder	18.46	10.62	18	872898	333	109716050
Dry skin	18.45	10.62	679	872237	106974	109609409
Potentiating drug interaction	18.45	10.62	156	872760	11487	109704896
Mydriasis	18.44	10.62	101	872815	22056	109694327
Acute motor-sensory axonal neuropathy	18.44	10.62	22	872894	516	109715867
Incorrect dose administered by device	18.39	10.62	16	872900	6798	109709585
Gastritis haemorrhagic	18.35	10.62	61	872855	3112	109713271
Tuberculosis	18.33	10.62	75	872841	17699	109698684
Salivary hypersecretion	18.29	10.62	73	872843	17348	109699035
Intraventricular haemorrhage	18.25	10.62	89	872827	5418	109710965
Bleeding time prolonged	18.17	10.62	35	872881	1267	109715116
Metastases to liver	18.10	10.62	185	872731	35201	109681182
Ocular icterus	18.07	10.62	95	872821	5958	109710425
Angiodermatitis	18.07	10.62	14	872902	187	109716196
Electrocardiogram T wave amplitude decreased	18.01	10.62	27	872889	794	109715589
Brain natriuretic peptide	17.98	10.62	9	872907	51	109716332
Complication of device removal	17.91	10.62	7	872909	4613	109711770
Bleeding varicose vein	17.91	10.62	25	872891	688	109715695
Blood glucose fluctuation	17.87	10.62	113	872803	7585	109708798
Rash pruritic	17.85	10.62	614	872302	97455	109618928
Fibromuscular dysplasia	17.72	10.62	17	872899	308	109716075
Intraocular pressure increased	17.71	10.62	37	872879	10839	109705544
Peripheral coldness	17.70	10.62	224	872692	18316	109698067
Inguinal hernia	17.69	10.62	113	872803	7612	109708771
Pulmonary valve incompetence	17.69	10.62	54	872862	2632	109713751
Electrocardiogram U wave present	17.65	10.62	12	872904	129	109716254
Tongue disorder	17.62	10.62	56	872860	14242	109702141
Spirometry abnormal	17.62	10.62	88	872828	5409	109710974
Hypoaldosteronism	17.62	10.62	24	872892	645	109715738
Linear IgA disease	17.57	10.62	75	872841	4314	109712069
Aortic valve calcification	17.55	10.62	28	872888	870	109715513
Pulseless electrical activity	17.54	10.62	206	872710	16551	109699832
Hypoprothrombinaemia	17.52	10.62	29	872887	930	109715453
Anal fissure	17.49	10.62	32	872884	9849	109706534
JC virus infection	17.46	10.62	10	872906	5280	109711103
Arteriospasm coronary	17.45	10.62	28	872888	9072	109707311
Lymphorrhoea	17.41	10.62	14	872902	198	109716185
Urine potassium increased	17.41	10.62	7	872909	21	109716362
Oesophageal variceal ligation	17.39	10.62	13	872903	164	109716219
Mouth ulceration	17.39	10.62	271	872645	47867	109668516
Endocarditis enterococcal	17.37	10.62	18	872898	359	109716024
Systolic dysfunction	17.34	10.62	75	872841	4340	109712043
Blood creatine abnormal	17.33	10.62	18	872898	360	109716023
Narrow anterior chamber angle	17.33	10.62	13	872903	165	109716218
Blood test abnormal	17.33	10.62	143	872773	28411	109687972
Urine odour abnormal	17.31	10.62	109	872807	7306	109709077
Stent placement	17.30	10.62	107	872809	7127	109709256
Liver transplant	17.29	10.62	77	872839	4512	109711871
Troponin I increased	17.28	10.62	87	872829	5365	109711018
Postpericardiotomy syndrome	17.27	10.62	8	872908	37	109716346
Periorbital haematoma	17.26	10.62	30	872886	1002	109715381
Aortic valve sclerosis	17.25	10.62	43	872873	1860	109714523
Coronary artery stenosis	17.10	10.62	175	872741	13583	109702800
Hyperparathyroidism primary	17.10	10.62	21	872895	508	109715875
Conjunctival haemorrhage	17.07	10.62	100	872816	6533	109709850
Haemorrhagic arteriovenous malformation	17.05	10.62	22	872894	560	109715823
Hepatocellular injury	17.05	10.62	522	872394	50120	109666263
Small intestinal haemorrhage	17.04	10.62	77	872839	4541	109711842
Incision site pain	17.01	10.62	59	872857	3076	109713307
Erythema	16.98	10.62	2027	870889	289420	109426963
Capillaritis	16.97	10.62	50	872866	2389	109713994
Bradyphrenia	16.95	10.62	154	872762	11574	109704809
Thirst	16.95	10.62	253	872663	21454	109694929
Catheter site inflammation	16.90	10.62	33	872883	1207	109715176
Loss of employment	16.87	10.62	3	872913	3341	109713042
Virologic failure	16.87	10.62	9	872907	4943	109711440
Cytopenia	16.87	10.62	154	872762	29962	109686421
Epidermolysis	16.85	10.62	32	872884	1146	109715237
Blood culture positive	16.82	10.62	125	872791	8851	109707532
Hidradenitis	16.81	10.62	10	872906	5170	109711213
Pulmonary arterial wedge pressure increased	16.75	10.62	23	872893	623	109715760
Proteinuria	16.70	10.62	424	872492	39594	109676789
Pulse absent	16.70	10.62	149	872767	11143	109705240
Waist circumference increased	16.64	10.62	41	872875	1760	109714623
Metastases to lung	16.63	10.62	110	872806	22953	109693430
Aplasia pure red cell	16.62	10.62	131	872785	9447	109706936
Catarrh	16.61	10.62	107	872809	7228	109709155
Catheter removal	16.58	10.62	23	872893	629	109715754
Respiratory alkalosis	16.54	10.62	89	872827	5632	109710751
Cerebral artery thrombosis	16.52	10.62	39	872877	1629	109714754
Dactylitis	16.46	10.62	6	872910	4127	109712256
Nasal mucosal erosion	16.43	10.62	9	872907	63	109716320
Infective exacerbation of chronic obstructive airways disease	16.42	10.62	59	872857	3131	109713252
Cerebellar haemorrhage	16.41	10.62	60	872856	3211	109713172
Peripheral embolism	16.40	10.62	44	872872	1991	109714392
Cardiac resynchronisation therapy	16.37	10.62	10	872906	88	109716295
Pulmonary artery dilatation	16.37	10.62	23	872893	637	109715746
Cerebral artery embolism	16.36	10.62	45	872871	2067	109714316
Malignant melanoma	16.36	10.62	73	872843	16818	109699565
Ventricular failure	16.35	10.62	21	872895	532	109715851
Wrong technique in product usage process	16.33	10.62	545	872371	86803	109629580
Herpes zoster	16.32	10.62	694	872222	107685	109608698
Cardiac rehabilitation therapy	16.28	10.62	6	872910	13	109716370
Medical device site thrombosis	16.27	10.62	11	872905	117	109716266
Right atrial pressure increased	16.25	10.62	17	872899	343	109716040
Nephrolithiasis	16.22	10.62	398	872518	65814	109650569
Upper respiratory tract inflammation	16.21	10.62	73	872843	4298	109712085
Anger	16.17	10.62	86	872830	18921	109697462
Electrocardiogram QRS complex abnormal	16.14	10.62	25	872891	757	109715626
Mania	16.12	10.62	97	872819	20699	109695684
Sleep terror	16.11	10.62	17	872899	6593	109709790
Cardiac failure high output	16.09	10.62	20	872896	490	109715893
Type I hypersensitivity	16.09	10.62	16	872900	6377	109710006
Anticoagulation drug level abnormal	16.06	10.62	16	872900	304	109716079
Intra-abdominal haemorrhage	16.06	10.62	84	872832	5258	109711125
Pericardial fibrosis	16.00	10.62	14	872902	224	109716159
Renal tubular disorder	15.99	10.62	107	872809	7322	109709061
Calculus urinary	15.97	10.62	58	872858	3094	109713289
Blood bicarbonate decreased	15.97	10.62	89	872827	5708	109710675
Prescription drug used without a prescription	15.96	10.62	12	872904	5484	109710899
Intentional dose omission	15.92	10.62	93	872823	19987	109696396
Rheumatoid lung	15.92	10.62	7	872909	4297	109712086
Diaphragmatic paralysis	15.92	10.62	33	872883	1261	109715122
Pericarditis constrictive	15.91	10.62	29	872887	1006	109715377
Cardiac asthma	15.89	10.62	15	872901	266	109716117
Colon cancer	15.84	10.62	199	872717	16244	109700139
Chest injury	15.83	10.62	61	872855	3348	109713035
Catheter site rash	15.81	10.62	29	872887	1011	109715372
Injection site inflammation	15.78	10.62	9	872907	4762	109711621
Pulmonary interstitial emphysema syndrome	15.71	10.62	21	872895	554	109715829
Skin turgor decreased	15.70	10.62	26	872890	834	109715549
Cough	15.65	10.62	3986	868930	457655	109258728
Rash morbilliform	15.63	10.62	112	872804	7839	109708544
Sacroiliitis	15.61	10.62	10	872906	4968	109711415
Toxic anterior segment syndrome	15.59	10.62	4	872912	3450	109712933
Cytomegalovirus chorioretinitis	15.58	10.62	20	872896	7108	109709275
Anaemia of chronic disease	15.57	10.62	59	872857	3213	109713170
Oxygen consumption decreased	15.54	10.62	20	872896	508	109715875
Maternal exposure during breast feeding	15.50	10.62	7	872909	4231	109712152
Foot operation	15.49	10.62	21	872895	7292	109709091
Prothrombin level decreased	15.47	10.62	40	872876	1770	109714613
Temperature regulation disorder	15.40	10.62	162	872754	12664	109703719
Stroke volume decreased	15.40	10.62	4	872912	0	109716383
Nodule	15.32	10.62	174	872742	32457	109683926
Affective disorder	15.32	10.62	42	872874	11199	109705184
Complications of transplanted kidney	15.31	10.62	106	872810	7336	109709047
Renal atrophy	15.30	10.62	47	872869	2299	109714084
Immune-mediated hepatic disorder	15.29	10.62	8	872908	4442	109711941
Extremity necrosis	15.25	10.62	65	872851	3737	109712646
Urinary tract candidiasis	15.25	10.62	31	872885	1168	109715215
Diffuse large B-cell lymphoma	15.22	10.62	69	872847	15829	109700554
Tuberculin test positive	15.17	10.62	5	872911	3663	109712720
Deep vein thrombosis	15.16	10.62	1292	871624	138595	109577788
Catheter site irritation	15.16	10.62	22	872894	628	109715755
Suspected suicide	15.14	10.62	65	872851	15134	109701249
Hypertensive cardiomyopathy	15.13	10.62	17	872899	373	109716010
Post procedural complication	15.10	10.62	295	872621	26363	109690020
Biopsy liver	15.08	10.62	22	872894	631	109715752
Basilar artery occlusion	15.06	10.62	15	872901	285	109716098
Adenovirus infection	15.04	10.62	41	872875	10953	109705430
Partial seizures	15.02	10.62	43	872873	11306	109705077
Oesophagitis	15.01	10.62	314	872602	28401	109687982
Cheyne-Stokes respiration	15.01	10.62	20	872896	526	109715857
Face oedema	14.98	10.62	358	872558	33111	109683272
Cystostomy	14.94	10.62	9	872907	77	109716306
Refusal of treatment by patient	14.94	10.62	127	872789	9367	109707016
Meningitis aseptic	14.90	10.62	35	872881	9835	109706548
Hypokalaemic syndrome	14.90	10.62	11	872905	136	109716247
Fistula	14.89	10.62	66	872850	15233	109701150
Gastritis	14.88	10.62	541	872375	53158	109663225
Venous pressure increased	14.84	10.62	7	872909	34	109716349
Decreased appetite	14.84	10.62	4094	868822	471752	109244631
Catatonia	14.82	10.62	43	872873	11257	109705126
Somatic delusion	14.81	10.62	23	872893	698	109715685
Hypoxic-ischaemic encephalopathy	14.80	10.62	120	872796	8727	109707656
Skin burning sensation	14.80	10.62	106	872810	21719	109694664
Vena cava injury	14.79	10.62	16	872900	336	109716047
Gastric varices haemorrhage	14.78	10.62	19	872897	482	109715901
Peritoneal dialysis complication	14.77	10.62	49	872867	2497	109713886
Deafness bilateral	14.77	10.62	51	872865	2653	109713730
Febrile nonhaemolytic transfusion reaction	14.77	10.62	11	872905	138	109716245
QRS axis abnormal	14.77	10.62	48	872868	2420	109713963
Allergy to chemicals	14.72	10.62	4	872912	3321	109713062
Chest tube insertion	14.70	10.62	11	872905	139	109716244
Antineutrophil cytoplasmic antibody positive	14.70	10.62	79	872837	4997	109711386
Middle insomnia	14.68	10.62	98	872818	20404	109695979
Burns second degree	14.67	10.62	108	872808	7625	109708758
Organ failure	14.66	10.62	76	872840	4741	109711642
Resting tremor	14.65	10.62	38	872878	1685	109714698
Base excess decreased	14.64	10.62	17	872899	387	109715996
Bifascicular block	14.64	10.62	17	872899	387	109715996
Blood cholesterol decreased	14.64	10.62	51	872865	2665	109713718
Metastatic renal cell carcinoma	14.63	10.62	48	872868	2432	109713951
Hepatitis B	14.58	10.62	34	872882	9578	109706805
Foot fracture	14.58	10.62	130	872786	25416	109690967
Blood aldosterone increased	14.55	10.62	13	872903	214	109716169
Oral candidiasis	14.52	10.62	257	872659	44503	109671880
Device defective	14.48	10.62	6	872910	3816	109712567
Ventricular dyskinesia	14.48	10.62	18	872898	441	109715942
Menstrual disorder	14.48	10.62	10	872906	4774	109711609
Face injury	14.46	10.62	72	872844	4420	109711963
Fabry's disease	14.46	10.62	6	872910	20	109716363
Traumatic haematoma	14.41	10.62	47	872869	2374	109714009
Rash vesicular	14.39	10.62	63	872853	14589	109701794
Calcification metastatic	14.38	10.62	11	872905	144	109716239
Thalamus haemorrhage	14.38	10.62	41	872875	1923	109714460
Renal hypertrophy	14.37	10.62	7	872909	37	109716346
Thermohypoaesthesia	14.37	10.62	10	872906	112	109716271
Cushingoid	14.34	10.62	46	872870	11666	109704717
Acute graft versus host disease in intestine	14.32	10.62	14	872902	5625	109710758
Tachycardia induced cardiomyopathy	14.31	10.62	13	872903	219	109716164
Renin increased	14.28	10.62	16	872900	350	109716033
Hypophysitis	14.27	10.62	13	872903	5402	109710981
Body mass index abnormal	14.26	10.62	26	872890	902	109715481
Paranasal sinus discomfort	14.24	10.62	93	872823	6312	109710071
Pharyngeal swelling	14.22	10.62	48	872868	11984	109704399
Productive cough	14.22	10.62	1067	871849	113238	109603145
Glomerulonephritis acute	14.21	10.62	15	872901	306	109716077
Electrocardiogram T wave inversion	14.21	10.62	85	872831	5595	109710788
Myocardiac abscess	14.20	10.62	9	872907	85	109716298
Splenic injury	14.18	10.62	14	872902	263	109716120
Renal vessel disorder	14.17	10.62	15	872901	307	109716076
Platelet transfusion	14.11	10.62	52	872864	2794	109713589
Carotid artery stenosis	14.09	10.62	123	872793	9140	109707243
Procedural haemorrhage	14.08	10.62	82	872834	5345	109711038
Diverticulum intestinal	14.06	10.62	148	872768	11571	109704812
Endophthalmitis	14.06	10.62	27	872889	8160	109708223
Catheterisation cardiac abnormal	14.06	10.62	15	872901	310	109716073
Sensitivity to weather change	14.02	10.62	37	872879	9991	109706392
Hypermagnesaemia	14.01	10.62	36	872880	1587	109714796
Tongue dry	14.00	10.62	32	872884	1308	109715075
Peritoneal cloudy effluent	13.92	10.62	22	872894	678	109715705
Blood pressure diastolic increased	13.92	10.62	89	872827	18718	109697665
Ocular discomfort	13.92	10.62	29	872887	8504	109707879
Aspergillus infection	13.91	10.62	132	872784	25484	109690899
Urethral haemorrhage	13.91	10.62	19	872897	512	109715871
Transient ischaemic attack	13.89	10.62	628	872288	63354	109653029
Multiple injuries	13.89	10.62	61	872855	3553	109712830
Metastases to meninges	13.89	10.62	12	872904	5116	109711267
Electrocardiogram T wave biphasic	13.89	10.62	13	872903	228	109716155
Heart sounds	13.88	10.62	29	872887	1114	109715269
Acid base balance abnormal	13.81	10.62	18	872898	463	109715920
Hot flush	13.81	10.62	406	872510	65630	109650753
Neurotoxicity	13.80	10.62	242	872674	41965	109674418
Myocardial necrosis marker increased	13.80	10.62	64	872852	3816	109712567
Coma uraemic	13.79	10.62	7	872909	41	109716342
Immunisation	13.77	10.62	4	872912	3179	109713204
Large intestine polyp	13.74	10.62	181	872735	14936	109701447
Biliary cyst	13.73	10.62	10	872906	121	109716262
Thyroxine free decreased	13.72	10.62	30	872886	1190	109715193
Ulcer haemorrhage	13.71	10.62	113	872803	22458	109693925
Wrong patient received product	13.70	10.62	95	872821	6579	109709804
Aphthous ulcer	13.69	10.62	104	872812	21032	109695351
Temperature intolerance	13.68	10.62	60	872856	13890	109702493
Rhinitis allergic	13.68	10.62	84	872832	17838	109698545
Angiodysplasia	13.68	10.62	34	872882	1468	109714915
Vanishing bile duct syndrome	13.68	10.62	4	872912	3164	109713219
Scleroedema	13.66	10.62	11	872905	156	109716227
Peau d'orange	13.64	10.62	14	872902	276	109716107
Tachycardia	13.62	10.62	1573	871343	225072	109491311
Immune-mediated hypothyroidism	13.62	10.62	3	872913	2872	109713511
Cardiac dysfunction	13.62	10.62	90	872826	6133	109710250
Skin laceration	13.61	10.62	356	872560	33397	109682986
Pre-eclampsia	13.61	10.62	30	872886	8620	109707763
Fibrin degradation products increased	13.57	10.62	17	872899	420	109715963
Vasculitis necrotising	13.55	10.62	35	872881	1548	109714835
Therapeutic reaction time decreased	13.53	10.62	13	872903	5266	109711117
Urine protein/creatinine ratio decreased	13.52	10.62	5	872911	11	109716372
Femoral pulse decreased	13.52	10.62	5	872911	11	109716372
Oesophageal perforation	13.50	10.62	36	872880	1623	109714760
Lupus pneumonitis	13.46	10.62	10	872906	125	109716258
White blood cell count decreased	13.41	10.62	1595	871321	227795	109488588
Polymyalgia rheumatica	13.40	10.62	92	872824	6350	109710033
Abdominal hernia	13.39	10.62	94	872822	6535	109709848
Fear of death	13.39	10.62	36	872880	1631	109714752
Catheter site pain	13.37	10.62	92	872824	6354	109710029
Peripheral circulatory failure	13.34	10.62	38	872878	1781	109714602
Urinary incontinence	13.34	10.62	489	872427	48098	109668285
Tracheostomy	13.31	10.62	34	872882	1493	109714890
Epstein-Barr virus associated lymphoproliferative disorder	13.30	10.62	11	872905	4791	109711592
Abdominal distension	13.29	10.62	1578	871338	173525	109542858
Dust allergy	13.26	10.62	87	872829	5914	109710469
Cardio-respiratory distress	13.25	10.62	14	872902	286	109716097
Device alarm issue	13.24	10.62	46	872870	2400	109713983
Hypertensive emergency	13.21	10.62	57	872859	3294	109713089
Cholangiostomy	13.18	10.62	4	872912	3	109716380
Soft tissue disorder	13.18	10.62	59	872857	3465	109712918
Injection site discolouration	13.18	10.62	33	872883	9070	109707313
Dysmenorrhoea	13.15	10.62	6	872910	3604	109712779
Cardiac autonomic neuropathy	13.13	10.62	8	872908	70	109716313
Renal embolism	13.12	10.62	12	872904	204	109716179
Rectal ulcer haemorrhage	13.11	10.62	15	872901	336	109716047
Bone cyst	13.10	10.62	6	872910	3597	109712786
Carotid artery disease	13.09	10.62	43	872873	2180	109714203
Surgery	13.09	10.62	238	872678	41045	109675338
Agonal rhythm	13.07	10.62	12	872904	205	109716178
Extradural haematoma	13.05	10.62	57	872859	3312	109713071
Tenderness	13.04	10.62	159	872757	29278	109687105
Pulmonary embolism	13.03	10.62	1907	871009	212567	109503816
Sarcoidosis	13.02	10.62	53	872863	12526	109703857
Traumatic intracranial haemorrhage	13.01	10.62	33	872883	1443	109714940
Mineral supplementation	13.00	10.62	24	872892	841	109715542
Urine chloride decreased	12.99	10.62	9	872907	100	109716283
Heart valve replacement	12.99	10.62	29	872887	1167	109715216
Blood magnesium decreased	12.97	10.62	226	872690	19770	109696613
Glomerulonephritis membranous	12.94	10.62	40	872876	1963	109714420
Kidney small	12.84	10.62	13	872903	252	109716131
Senile dementia	12.84	10.62	13	872903	252	109716131
Disseminated tuberculosis	12.81	10.62	13	872903	5133	109711250
Respiratory tract congestion	12.80	10.62	169	872747	30688	109685695
Embedded device	12.79	10.62	8	872908	4025	109712358
Psychiatric decompensation	12.78	10.62	16	872900	5749	109710634
Vascular anastomotic haemorrhage	12.76	10.62	14	872902	299	109716084
Cardiac valve replacement complication	12.75	10.62	12	872904	212	109716171
Influenza	12.71	10.62	1155	871761	167946	109548437
Femoral artery aneurysm	12.70	10.62	12	872904	213	109716170
Conjunctivitis allergic	12.69	10.62	96	872820	6835	109709548
Pseudomonal sepsis	12.68	10.62	118	872798	8928	109707455
Pneumonia staphylococcal	12.68	10.62	87	872829	6004	109710379
SARS-CoV-2 antibody test positive	12.65	10.62	16	872900	399	109715984
Base excess increased	12.64	10.62	10	872906	138	109716245
Pulmonary function test abnormal	12.62	10.62	75	872841	4925	109711458
Vascular calcification	12.62	10.62	28	872888	1122	109715261
Hypoglycaemic unconsciousness	12.60	10.62	29	872887	1191	109715192
Metastases to bone	12.59	10.62	173	872743	31199	109685184
Systolic anterior motion of mitral valve	12.59	10.62	8	872908	76	109716307
Hyperamylasaemia	12.59	10.62	29	872887	1192	109715191
Bladder catheterisation	12.59	10.62	28	872888	1124	109715259
Glycosylated haemoglobin increased	12.58	10.62	259	872657	23360	109693023
Electrocardiogram ST segment depression	12.58	10.62	80	872836	5381	109711002
Brain compression	12.57	10.62	22	872894	739	109715644
Oesophageal ulcer haemorrhage	12.57	10.62	25	872891	927	109715456
Unresponsive to stimuli	12.55	10.62	620	872296	63170	109653213
Atrial tachycardia	12.51	10.62	119	872797	9059	109707324
Herpes simplex	12.50	10.62	73	872843	15691	109700692
Cardiothoracic ratio increased	12.50	10.62	8	872908	77	109716306
Shoshin beriberi	12.50	10.62	8	872908	77	109716306
Eye disorder	12.48	10.62	157	872759	28749	109687634
Diagnostic procedure	12.47	10.62	11	872905	178	109716205
Pericardial calcification	12.44	10.62	7	872909	52	109716331
Endometriosis male	12.44	10.62	5	872911	15	109716368
Tic	12.42	10.62	6	872910	3487	109712896
Protein urine present	12.39	10.62	142	872774	11342	109705041
Walking disability	12.37	10.62	46	872870	2482	109713901
Lens dislocation	12.37	10.62	11	872905	180	109716203
Tension headache	12.33	10.62	37	872879	9581	109706802
Respiratory depression	12.30	10.62	178	872738	31823	109684560
Urine sodium decreased	12.28	10.62	13	872903	266	109716117
PO2 abnormal	12.28	10.62	6	872910	32	109716351
Analgesic drug level increased	12.27	10.62	8	872908	3938	109712445
ECG signs of myocardial ischaemia	12.26	10.62	16	872900	412	109715971
Primary hyperaldosteronism	12.25	10.62	13	872903	267	109716116
Respiratory rate decreased	12.21	10.62	88	872828	6170	109710213
Cystitis klebsiella	12.20	10.62	16	872900	414	109715969
Dermatitis allergic	12.20	10.62	111	872805	21613	109694770
Thyroid disorder	12.19	10.62	195	872721	16774	109699609
Eye infection	12.18	10.62	66	872850	14452	109701931
Wrong strength	12.17	10.62	12	872904	225	109716158
Alcohol interaction	12.17	10.62	7	872909	3687	109712696
Electrocardiogram ST-T change	12.17	10.62	34	872882	1576	109714807
Aortic arteriosclerosis	12.14	10.62	136	872780	10802	109705581
Lung opacity	12.12	10.62	49	872867	11603	109704780
Rectal polyp	12.11	10.62	33	872883	1507	109714876
Inferior vena cava syndrome	12.08	10.62	9	872907	113	109716270
International normalised ratio	12.08	10.62	9	872907	113	109716270
Dependence on oxygen therapy	12.07	10.62	21	872895	702	109715681
Ventricular enlargement	12.05	10.62	21	872895	703	109715680
Exposure to SARS-CoV-2	12.04	10.62	4	872912	2915	109713468
Bone density abnormal	12.02	10.62	8	872908	3895	109712488
Euphoric mood	12.01	10.62	33	872883	8794	109707589
Bundle branch block bilateral	12.01	10.62	9	872907	114	109716269
Renal haematoma	12.01	10.62	25	872891	958	109715425
Diet noncompliance	11.99	10.62	19	872897	587	109715796
Oesophageal spasm	11.97	10.62	59	872857	3607	109712776
Premature labour	11.96	10.62	35	872881	9137	109707246
Pulmonary nocardiosis	11.95	10.62	3	872913	2626	109713757
Joint contracture	11.92	10.62	45	872871	2446	109713937
Carcinoid tumour of the small bowel	11.91	10.62	16	872900	424	109715959
Pulse pressure decreased	11.91	10.62	16	872900	424	109715959
Procedural failure	11.90	10.62	10	872906	151	109716232
Cystitis escherichia	11.89	10.62	22	872894	772	109715611
Cerebral venous sinus thrombosis	11.88	10.62	4	872912	2891	109713492
Sinus congestion	11.85	10.62	169	872747	30290	109686093
Viral haemorrhagic cystitis	11.84	10.62	6	872910	3393	109712990
Drug effect less than expected	11.84	10.62	25	872891	7295	109709088
Mucocutaneous haemorrhage	11.83	10.62	13	872903	278	109716105
Staphylococcus test positive	11.81	10.62	99	872817	7271	109709112
Lyme disease	11.81	10.62	10	872906	4306	109712077
Sodium retention	11.80	10.62	12	872904	234	109716149
Skin induration	11.79	10.62	67	872849	4328	109712055
Oedema blister	11.78	10.62	4	872912	6	109716377
Granular cell tumour	11.78	10.62	4	872912	6	109716377
Transfusion-related acute lung injury	11.77	10.62	16	872900	429	109715954
Schizoaffective disorder	11.76	10.62	5	872911	3131	109713252
Haemoglobin abnormal	11.73	10.62	116	872800	8922	109707461
Gastrointestinal inflammation	11.73	10.62	37	872879	9432	109706951
Hallucination, visual	11.72	10.62	402	872514	39203	109677180
Back disorder	11.71	10.62	107	872809	20815	109695568
Body temperature decreased	11.69	10.62	213	872703	36722	109679661
Hydrocele	11.67	10.62	29	872887	1252	109715131
Abdominal sepsis	11.65	10.62	43	872873	2312	109714071
Oculogyric crisis	11.61	10.62	8	872908	3824	109712559
Lacrimation increased	11.60	10.62	173	872743	30777	109685606
Attention deficit hyperactivity disorder	11.58	10.62	11	872905	4480	109711903
Urine osmolarity decreased	11.57	10.62	9	872907	121	109716262
Mixed liver injury	11.56	10.62	146	872770	11933	109704450
Blood parathyroid hormone increased	11.56	10.62	65	872851	4183	109712200
Blood zinc decreased	11.56	10.62	5	872911	19	109716364
Toe amputation	11.55	10.62	66	872850	4272	109712111
Fluid balance negative	11.55	10.62	3	872913	0	109716383
Blood creatine	11.55	10.62	3	872913	0	109716383
Tongue amyloidosis	11.55	10.62	3	872913	0	109716383
Nasal obstruction	11.54	10.62	6	872910	3344	109713039
Stillbirth	11.52	10.62	10	872906	4254	109712129
Hyperparathyroidism	11.52	10.62	60	872856	3750	109712633
Device inappropriate shock delivery	11.51	10.62	7	872909	61	109716322
Lung consolidation	11.51	10.62	130	872786	10346	109706037
Caesarean section	11.49	10.62	63	872853	13754	109702629
Primary biliary cholangitis	11.48	10.62	31	872885	1408	109714975
International normalised ratio fluctuation	11.48	10.62	63	872853	4017	109712366
Mucosal dryness	11.45	10.62	65	872851	4198	109712185
Patent ductus arteriosus repair	11.44	10.62	6	872910	38	109716345
Clostridium test positive	11.44	10.62	134	872782	10759	109705624
Cardioactive drug level decreased	11.43	10.62	11	872905	200	109716183
Food refusal	11.42	10.62	24	872892	926	109715457
Therapy change	11.41	10.62	125	872791	9872	109706511
Papilloedema	11.41	10.62	26	872890	7383	109709000
Presbyacusis	11.39	10.62	4	872912	2815	109713568
Arterial disorder	11.39	10.62	41	872875	2178	109714205
Choking	11.37	10.62	175	872741	14935	109701448
Pneumonia cryptococcal	11.36	10.62	3	872913	2539	109713844
Cerebellar haematoma	11.35	10.62	19	872897	615	109715768
Gait disturbance	11.33	10.62	1977	870939	276231	109440152
Haemorrhagic infarction	11.32	10.62	23	872893	866	109715517
Peripheral sensory neuropathy	11.31	10.62	81	872835	16599	109699784
Upper-airway cough syndrome	11.30	10.62	182	872734	15675	109700708
Catheter site scab	11.28	10.62	12	872904	247	109716136
Xyphoid retraction	11.28	10.62	10	872906	163	109716220
Body temperature fluctuation	11.27	10.62	8	872908	3765	109712618
Gastrointestinal angiectasia	11.24	10.62	15	872901	395	109715988
Ultrafiltration failure	11.24	10.62	15	872901	395	109715988
Haemoperitoneum	11.24	10.62	77	872839	5311	109711072
Anaemia folate deficiency	11.23	10.62	20	872896	681	109715702
Peripheral artery thrombosis	11.23	10.62	62	872854	3962	109712421
White blood cell count increased	11.22	10.62	899	872017	95943	109620440
Hepatic cancer stage IV	11.18	10.62	3	872913	2512	109713871
Abnormal behaviour	11.17	10.62	229	872687	38810	109677573
Cholecystitis chronic	11.16	10.62	38	872878	9462	109706921
Loss of therapeutic response	11.15	10.62	3	872913	2507	109713876
Latent tuberculosis	11.15	10.62	9	872907	3968	109712415
Chemical burn of oral cavity	11.15	10.62	7	872909	65	109716318
Tongue haematoma	11.13	10.62	12	872904	251	109716132
Anaemia macrocytic	11.13	10.62	97	872819	7206	109709177
Bone pain	11.12	10.62	411	872505	64722	109651661
Milk-alkali syndrome	11.11	10.62	38	872878	1967	109714416
Fear of eating	11.07	10.62	17	872899	511	109715872
Substance-induced psychotic disorder	11.07	10.62	16	872900	5408	109710975
Transcatheter aortic valve implantation	11.06	10.62	7	872909	66	109716317
SARS-CoV-2 sepsis	11.06	10.62	12	872904	253	109716130
Cell death	11.05	10.62	81	872835	5710	109710673
Arteriovenous fistula operation	11.04	10.62	14	872902	350	109716033
Deformity	11.03	10.62	42	872874	10118	109706265
Bloody peritoneal effluent	11.03	10.62	10	872906	168	109716215
Dizziness exertional	11.02	10.62	21	872895	754	109715629
Vascular resistance systemic decreased	11.02	10.62	12	872904	254	109716129
Polypectomy	11.01	10.62	32	872884	1517	109714866
Phantom limb syndrome	11.01	10.62	15	872901	403	109715980
Rebound effect	10.99	10.62	70	872846	14736	109701647
Tricuspid valve replacement	10.99	10.62	5	872911	22	109716361
Brain contusion	10.97	10.62	33	872883	1595	109714788
Procedural pain	10.97	10.62	206	872710	35359	109681024
Blood pressure immeasurable	10.96	10.62	43	872873	2380	109714003
Diarrhoea infectious	10.96	10.62	37	872879	1903	109714480
Synovial disorder	10.95	10.62	5	872911	3002	109713381
Diabetes mellitus	10.94	10.62	919	871997	98462	109617921
Cardiac function test abnormal	10.94	10.62	10	872906	170	109716213
Lip erosion	10.90	10.62	36	872880	1830	109714553
Pneumonia bacterial	10.89	10.62	278	872638	25983	109690400
Bronchoscopy abnormal	10.88	10.62	7	872909	68	109716315
Sight disability	10.88	10.62	11	872905	213	109716170
Cardiac pacemaker evaluation	10.87	10.62	9	872907	133	109716250
Drug monitoring procedure incorrectly performed	10.87	10.62	21	872895	762	109715621
Nightmare	10.82	10.62	229	872687	38634	109677749
Ejection fraction abnormal	10.81	10.62	55	872861	3405	109712978
Neuroglycopenia	10.80	10.62	26	872890	1100	109715283
Laboratory test abnormal	10.78	10.62	265	872651	43814	109672569
Drop attacks	10.77	10.62	26	872890	1102	109715281
Serositis	10.76	10.62	32	872884	1537	109714846
Respiratory disorder	10.76	10.62	457	872459	70925	109645458
Diabetic gastropathy	10.76	10.62	4	872912	9	109716374
Pneumonia viral	10.74	10.62	135	872781	11022	109705361
Arthrodesis	10.74	10.62	4	872912	2714	109713669
Puncture site haematoma	10.73	10.62	12	872904	262	109716121
Urine phosphorus decreased	10.72	10.62	6	872910	44	109716339
Sinusitis bacterial	10.71	10.62	3	872913	2441	109713942
Enteritis	10.71	10.62	98	872818	19058	109697325
Stupor	10.69	10.62	106	872810	8159	109708224
Joint noise	10.66	10.62	15	872901	5128	109711255
Viraemia	10.63	10.62	10	872906	4092	109712291
Cystic fibrosis	10.63	10.62	13	872903	4718	109711665
Vascular dementia	10.63	10.62	23	872893	906	109715477

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypocalvaria	38.22	22.42	13	593	36	113311
Angiotensin converting enzyme inhibitor foetopathy	23.38	22.42	9	597	39	113308
Anuria	23.27	22.42	8	598	23	113324
Foetal disorder	22.67	22.42	26	580	895	112452

Pharmacologic Action:

Source	Code	Description
ATC	C03CA01	CARDIOVASCULAR SYSTEM DIURETICS HIGH-CEILING DIURETICS Sulfonamides, plain
ATC	C03CB01	CARDIOVASCULAR SYSTEM DIURETICS HIGH-CEILING DIURETICS Sulfonamides and potassium in combination
ATC	C03EB01	CARDIOVASCULAR SYSTEM DIURETICS DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION High-ceiling diuretics and potassium-sparing agents
FDA PE	N0000175366	Increased Diuresis at Loop of Henle
MeSH PA	D004232	Diuretics
MeSH PA	D045283	Natriuretic Agents
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D049994	Sodium Potassium Chloride Symporter Inhibitors
FDA EPC	N0000175590	Loop Diuretic
CHEBI has role	CHEBI:35476	antipsychotic agent
CHEBI has role	CHEBI:35526	hypoglycemic agent
CHEBI has role	CHEBI:35554	cardiovascular drug
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:35674	antihypertensive agent
CHEBI has role	CHEBI:35703	xenobiotic
CHEBI has role	CHEBI:62868	hepatoprotective agent
CHEBI has role	CHEBI:75835	anti-anaemic agent
CHEBI has role	CHEBI:77608	loop diuretic
CHEBI has role	CHEBI:78298	environmental contaminant
CHEBI has role	CHEBI:145947	antiatherosclerotic agent
CHEBI has role	CHEBI:231911	renoprotective agent
CHEBI has role	CHEBI:233423	antifibrotic agent

Related Drugs by ATC class:

C03CA Sulfonamides, plain 3 drugs

bumetanide piretanide torsemide

C03CB Sulfonamides and potassium in combination 1 drug

bumetanide

C03EB High-ceiling diuretics and potassium-sparing agents 2 drugs

bumetanide torsemide

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763
Acute pulmonary edema	indication	40541001
Decompensated cardiac failure	indication	195111005
Edema	indication	267038008
Pulmonary Edema due to Chronic Heart Failure	indication
Edema due to Hepatic Cirrhosis	indication
Peripheral Edema due to Chronic Heart Failure	indication
Hypercalcemia	off-label use	66931009	DOID:12678
Prevention of Oliguria	off-label use
Metabolic alkalosis	contraindication	1388004
Anuria	contraindication	2472002	DOID:2983
Hypocalcemia	contraindication	5291005
Hypochloremia	contraindication	10399008
Myocardial infarction	contraindication	22298006	DOID:5844
Hypovolemia	contraindication	28560003
Orthostatic hypotension	contraindication	28651003
Hyperuricemia	contraindication	35885006	DOID:1920
Hypokalemia	contraindication	43339004
Low blood pressure	contraindication	45007003
Systemic lupus erythematosus	contraindication	55464009	DOID:9074
Diabetes mellitus	contraindication	73211009	DOID:9351
Pancreatitis	contraindication	75694006	DOID:4989
Cardiogenic shock	contraindication	89138009
Hyponatremia	contraindication	89627008
Gout	contraindication	90560007	DOID:13189
Hearing disorder	contraindication	128540005
Hypomagnesemia	contraindication	190855004
Bladder outflow obstruction	contraindication	236645006
Benign prostatic hyperplasia	contraindication	266569009
Azotemia	contraindication	445009001

🐶 Veterinary Drug Use

Species	Use	Relation
Cats	Edema (pulmonary congestion, ascites) associated with cardiac insufficiency	Indication
Cats	Acute noninflammatory tissue edema	Indication
Cattle	Physiological parturient edema of the mammary gland and associated structures	Indication
Dogs	Edema (pulmonary congestion, ascites) associated with cardiac insufficiency	Indication
Dogs	Acute noninflammatory tissue edema	Indication
Horses	Edema (pulmonary congestion, ascites) associated with cardiac insufficiency	Indication
Horses	Acute noninflammatory tissue edema	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Salix Injection 5%	Intervet Inc.	1
Salix Tablets	Intervet Inc.	1
Lasix Packets	Intervet Inc.	1
Lasix Syrup 1%	Intervet Inc.	1
Furos-A-Vet	Bimeda Animal Health Limited	1
Disal Injection	Boehringer lngelheim Animal Health USA Inc.	1
Disal	Boehringer lngelheim Animal Health USA Inc.	1
Disal	Boehringer lngelheim Animal Health USA Inc.	1
Furosemide Injection 5%	Elanco US Inc.	1
Furosemide Syrup 1%	First Priority Inc.	1
Furosemide Syrup 1%	Cronus Pharma Specialities India Private Limited	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.69	acidic
pKa2	10.59	acidic

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
80MG/10ML (8MG/ML)	FUROSCIX	SCPHARMACEUTICALS	N209988	Oct. 7, 2022	RX	SOLUTION	SUBCUTANEOUS	11433044	April 3, 2034	USE OF A LIQUID FORMULATION COMPRISING FUROSEMIDE TO TREAT CONGESTION DUE TO FLUID OVERLOAD (EDEMA) IN ADULTS WITH NYHA CLASS II/III CHRONIC HEART FAILURE
80MG/10ML (8MG/ML)	FUROSCIX	SCPHARMACEUTICALS	N209988	Oct. 7, 2022	RX	SOLUTION	SUBCUTANEOUS	12370168	April 3, 2034	USE OF A LIQUID FORMULATION COMPRISING FUROSEMIDE TO TREAT CONGESTION DUE TO FLUID OVERLOAD (EDEMA) IN ADULTS WITH NYHA CLASS II/III CHRONIC HEART FAILURE
80MG/10ML (8MG/ML)	FUROSCIX	SCPHARMACEUTICALS	N209988	Oct. 7, 2022	RX	SOLUTION	SUBCUTANEOUS	9884039	April 3, 2034	USE OF A LIQUID FORMULATION COMPRISING FUROSEMIDE TO TREAT CONGESTION DUE TO FLUID OVERLOAD (EDEMA) IN ADULTS WITH NYHA CLASS II/III CHRONIC HEART FAILURE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Solute carrier family 12 member 1	Transporter	Q13621	S12A1_HUMAN	INHIBITOR	IC50	6.20	WOMBAT-PK	CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-1	Transporter	P05023	AT1A1_HUMAN				WOMBAT-PK
ATP-binding cassette sub-family G member 2	Transporter	Q9UNQ0	ABCG2_HUMAN		IC50	5.50	CHEMBL
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN		Ki	7.21	CHEMBL
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN		Ki	6.25	CHEMBL
Carbonic anhydrase 9	Enzyme	Q16790	CAH9_HUMAN		Ki	6.38	CHEMBL
Carbonic anhydrase 12	Enzyme	O43570	CAH12_HUMAN		Ki	6.58	CHEMBL
Carbonic anhydrase 5A, mitochondrial	Enzyme	P35218	CAH5A_HUMAN		Ki	6.30	CHEMBL
Carbonic anhydrase 5B, mitochondrial	Enzyme	Q9Y2D0	CAH5B_HUMAN		Ki	6.49	CHEMBL
Carbonic anhydrase 7	Enzyme	P43166	CAH7_HUMAN		Ki	6.29	CHEMBL
Carbonic anhydrase 6	Enzyme	P23280	CAH6_HUMAN		Ki	6.61	CHEMBL
Carbonic anhydrase 14	Enzyme	Q9ULX7	CAH14_HUMAN		Ki	7.28	CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1	Enzyme	P28845	DHI1_HUMAN		IC50	5.42	CHEMBL
Solute carrier family 12 member 2	Transporter	P55011	S12A2_HUMAN	INHIBITOR	IC50	5.13	IUPHAR
G-protein coupled receptor 35	GPCR	Q9HC97	GPR35_HUMAN		Ki	5.49	CHEMBL
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN		Ki	7.19	CHEMBL
CDGSH iron-sulfur domain-containing protein 1	Membrane other	Q9NZ45	CISD1_HUMAN		Ki	5.64	CHEMBL
Carbonic anhydrase 13	Enzyme		CAH13_MOUSE		Ki	6.26	CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1	Enzyme		DHI1_MOUSE		IC50	5.42	CHEMBL
Holo-[acyl-carrieir-protein] synthase	Enzyme		ACPS_BACSU		IC50	4.90	CHEMBL

External reference:

ID	Source
4017830	VUID
N0000146188	NUI
D00331	KEGG_DRUG
4017830	VANDF
C0016860	UMLSCUI
CHEBI:47426	CHEBI
FUN	PDB_CHEM_ID
CHEMBL35	ChEMBL_ID
DB00695	DRUGBANK_ID
D005665	MESH_DESCRIPTOR_UI
3440	PUBCHEM_CID
4839	IUPHAR_LIGAND_ID
1584	INN_ID
7LXU5N7ZO5	UNII
4603	RXNORM
3962	MMSL
4769	MMSL
d00070	MMSL
002307	NDDF
387475002	SNOMEDCT_US
81609008	SNOMEDCT_US
7LXU5N7ZO5	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-3294	SOLUTION	10 mg	ORAL	ANDA	21 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-3298	SOLUTION	40 mg	ORAL	ANDA	21 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-4297	TABLET	20 mg	ORAL	NDA	21 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-4299	TABLET	40 mg	ORAL	NDA	21 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-4301	TABLET	80 mg	ORAL	ANDA	21 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-8297	TABLET	20 mg	ORAL	NDA	21 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-8299	TABLET	40 mg	ORAL	NDA	21 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-8301	TABLET	80 mg	ORAL	ANDA	21 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9155	INJECTION	10 mg	INTRAMUSCULAR	NDA	24 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9156	INJECTION	10 mg	INTRAMUSCULAR	NDA	24 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9157	INJECTION	10 mg	INTRAMUSCULAR	NDA	24 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9158	INJECTION	10 mg	INTRAMUSCULAR	NDA	24 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9159	INJECTION	10 mg	INTRAMUSCULAR	NDA	24 sections
FUROSEMIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9862	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	12 sections
FUROSEMIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9862	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	12 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9863	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	13 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9863	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	13 sections
FUROSEMIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9864	INJECTION, SOLUTION	20 mg	INTRAMUSCULAR	ANDA	12 sections
FUROSEMIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9864	INJECTION, SOLUTION	20 mg	INTRAMUSCULAR	ANDA	12 sections
FUROSEMIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0409-6102	INJECTION, SOLUTION	10 mg	INTRAMUSCULAR	NDA	24 sections
FUROSEMIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0409-6102	INJECTION, SOLUTION	10 mg	INTRAMUSCULAR	NDA	24 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8368	TABLET	20 mg	ORAL	ANDA	22 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8369	TABLET	40 mg	ORAL	ANDA	22 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8370	TABLET	80 mg	ORAL	ANDA	22 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7177	TABLET	20 mg	ORAL	ANDA	22 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7178	TABLET	40 mg	ORAL	ANDA	22 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	10135-832	TABLET	20 mg	ORAL	NDA	20 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	10135-833	TABLET	40 mg	ORAL	NDA	20 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	10135-834	TABLET	80 mg	ORAL	NDA	20 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	10544-131	TABLET	20 mg	ORAL	ANDA	13 sections