furosemide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diuretics, furosemide derivatives 1258 54-31-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • frusemide
  • furosemide
  • furosemid
A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
  • Molecular weight: 330.74
  • Formula: C12H11ClN2O5S
  • CLOGP: 1.90
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 122.63
  • ALOGS: -3.45
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
40 mg O
40 mg P
40 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 66 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 25.92 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 71 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.12 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 1, 1966 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 3215.99 10.26 6604 470352 234159 55580952
Cardiac failure congestive 2592.45 10.26 3447 473509 84273 55730838
Drug ineffective 1909.30 10.26 3042 473914 915947 54899164
Cardiac failure 1834.68 10.26 2825 474131 79268 55735843
Rheumatoid arthritis 1816.92 10.26 499 476457 382105 55433006
Hyperkalaemia 1442.15 10.26 1960 474996 48905 55766206
Pemphigus 1270.11 10.26 11 476945 157201 55657910
Hyponatraemia 1090.34 10.26 2565 474391 99574 55715537
Glossodynia 1058.48 10.26 57 476899 152401 55662710
Hand deformity 1035.98 10.26 21 476935 134471 55680640
Contraindicated product administered 1013.98 10.26 178 476778 186108 55629003
Systemic lupus erythematosus 962.97 10.26 180 476776 179898 55635213
Oedema peripheral 945.88 10.26 3395 473561 167859 55647252
Drug intolerance 910.88 10.26 559 476397 264259 55550852
Alopecia 897.45 10.26 704 476252 292754 55522357
Renal failure 891.27 10.26 2497 474459 108003 55707108
Hypotension 887.66 10.26 4334 472622 246174 55568937
Arthropathy 880.86 10.26 299 476657 199976 55615135
International normalised ratio increased 826.72 10.26 1401 475555 42640 55772471
Treatment failure 820.87 10.26 215 476741 170177 55644934
Infusion related reaction 810.66 10.26 378 476578 208553 55606558
Maternal exposure during pregnancy 797.83 10.26 304 476652 189249 55625862
Drug interaction 783.96 10.26 3686 473270 206069 55609042
Therapeutic product effect decreased 762.58 10.26 243 476713 169209 55645902
Dyspnoea 728.46 10.26 7939 469017 584638 55230473
Off label use 715.16 10.26 2376 474580 553804 55261307
Hypokalaemia 712.78 10.26 2084 474872 92353 55722758
Synovitis 684.90 10.26 255 476701 161050 55654061
Atrial fibrillation 681.99 10.26 2252 474704 106645 55708466
Abdominal discomfort 677.15 10.26 812 476144 276462 55538649
Pericarditis 667.99 10.26 72 476884 108851 55706260
Anaemia 642.00 10.26 4169 472787 263342 55551769
Bradycardia 622.08 10.26 1603 475353 65901 55749210
Joint swelling 609.53 10.26 946 476010 288854 55526257
Hypersensitivity 588.41 10.26 787 476169 255621 55559490
Pain 586.81 10.26 3266 473690 659918 55155193
Discomfort 583.72 10.26 235 476721 141526 55673585
Drug hypersensitivity 566.71 10.26 911 476045 274294 55540817
Rheumatoid factor positive 556.68 10.26 5 476951 69055 55746056
Arthralgia 555.14 10.26 2279 474677 499390 55315721
Wound 550.80 10.26 243 476713 138561 55676550
Fluid retention 540.96 10.26 1325 475631 52753 55762358
Pulmonary hypertension 539.93 10.26 1038 475918 34906 55780205
Fall 517.50 10.26 4957 471999 352553 55462558
Duodenal ulcer perforation 517.04 10.26 13 476943 68329 55746782
Hepatic enzyme increased 483.07 10.26 444 476512 170940 55644171
Renal impairment 477.56 10.26 1638 475318 79075 55736036
Product use issue 477.47 10.26 523 476433 185518 55629593
Rash 473.32 10.26 2360 474596 490687 55324424
Melaena 471.15 10.26 854 476102 27436 55787675
Dehydration 469.67 10.26 2615 474341 156210 55658901
Helicobacter infection 458.04 10.26 45 476911 73223 55741888
Right ventricular failure 448.57 10.26 621 476335 15758 55799353
Oedema 446.36 10.26 1618 475338 80302 55734809
Gastrointestinal haemorrhage 441.16 10.26 1532 475424 74419 55740692
Pulmonary arterial hypertension 438.75 10.26 798 476158 25705 55789406
Musculoskeletal stiffness 438.64 10.26 405 476551 155602 55659509
Blood creatinine increased 406.92 10.26 1548 475408 78643 55736468
Myocardial infarction 405.81 10.26 1711 475245 91159 55723952
Completed suicide 391.15 10.26 335 476621 133498 55681613
Folliculitis 379.95 10.26 21 476935 54958 55760153
Orthostatic hypotension 369.39 10.26 848 476108 32351 55782760
Pulmonary oedema 368.84 10.26 1111 475845 50032 55765079
Muscle injury 366.11 10.26 19 476937 52481 55762630
Syncope 349.12 10.26 1825 475131 106374 55708737
Blood urea increased 341.16 10.26 685 476271 23788 55791323
Lactic acidosis 340.69 10.26 854 476102 34492 55780619
Sleep disorder due to general medical condition, insomnia type 328.72 10.26 8 476948 43330 55771781
Hypoglycaemia 322.45 10.26 1124 475832 54691 55760420
Swelling 318.22 10.26 1008 475948 238763 55576348
Irritable bowel syndrome 313.41 10.26 95 476861 68363 55746748
Sinusitis 312.42 10.26 763 476193 196818 55618293
Hypervolaemia 309.02 10.26 689 476267 25769 55789342
Torsade de pointes 308.68 10.26 450 476506 11990 55803121
Exposure during pregnancy 304.79 10.26 426 476530 135916 55679195
Psoriatic arthropathy 302.35 10.26 124 476832 73884 55741227
Ascites 300.88 10.26 847 476109 36697 55778414
Fatigue 300.06 10.26 4793 472163 783759 55031352
Pleural effusion 296.83 10.26 1472 475484 84008 55731103
Abortion spontaneous 258.01 10.26 33 476923 43720 55771391
Therapeutic product effect incomplete 257.84 10.26 311 476645 105720 55709391
Injection site pain 245.09 10.26 383 476573 116735 55698376
Metabolic alkalosis 244.83 10.26 199 476757 2652 55812459
Nasopharyngitis 243.36 10.26 1004 475952 219955 55595156
Gastrointestinal disorder 243.12 10.26 361 476595 112341 55702770
Injection site erythema 241.03 10.26 182 476774 77266 55737845
Chronic kidney disease 238.63 10.26 842 476114 41214 55773897
Ill-defined disorder 234.75 10.26 145 476811 68398 55746713
Injection site reaction 234.65 10.26 79 476877 53168 55761943
Intentional product use issue 229.52 10.26 305 476651 99428 55715683
Creatinine renal clearance decreased 227.91 10.26 428 476528 14131 55800980
Pneumonia 225.50 10.26 4764 472192 402334 55412777
Rheumatic fever 223.86 10.26 4 476952 28823 55786288
Rhabdomyolysis 219.59 10.26 801 476155 39857 55775254
Respiratory failure 215.49 10.26 1462 475494 93600 55721511
Impaired healing 209.76 10.26 256 476700 86585 55728526
Cardiac failure chronic 209.48 10.26 213 476743 3854 55811257
Cardioactive drug level increased 206.94 10.26 158 476798 1911 55813200
Device expulsion 203.26 10.26 14 476942 30435 55784676
Haematoma 200.00 10.26 662 476294 31357 55783754
Electrocardiogram QT prolonged 193.68 10.26 946 476010 53642 55761469
Cardiac failure acute 189.02 10.26 299 476657 8574 55806537
Chronic obstructive pulmonary disease 184.06 10.26 967 475989 56448 55758663
Psoriasis 178.29 10.26 320 476636 92372 55722739
Death 177.50 10.26 3960 472996 337466 55477645
Haemoglobin decreased 177.30 10.26 1827 475129 132310 55682801
Lower respiratory tract infection 176.85 10.26 449 476507 114345 55700766
Hypoxia 172.94 10.26 908 476048 52989 55762122
Urine output decreased 172.66 10.26 320 476636 10457 55804654
Stomatitis 170.73 10.26 493 476463 120317 55694794
Intentional overdose 169.62 10.26 196 476760 67921 55747190
Multiple organ dysfunction syndrome 169.31 10.26 889 476067 51881 55763230
Hepatic encephalopathy 169.31 10.26 306 476650 9804 55805307
Dyspnoea exertional 167.75 10.26 910 476046 53779 55761332
Product use in unapproved indication 164.37 10.26 625 476331 140197 55674914
Hip arthroplasty 163.85 10.26 61 476895 38562 55776549
Acute myocardial infarction 159.26 10.26 593 476363 29800 55785311
Rectal haemorrhage 158.27 10.26 734 476222 40733 55774378
Suicide attempt 157.90 10.26 154 476802 57682 55757429
Infection 156.95 10.26 1022 475934 199184 55615927
Generalised oedema 155.34 10.26 365 476591 14136 55800975
Depressed level of consciousness 153.95 10.26 910 476046 55523 55759588
Injection site swelling 152.27 10.26 90 476866 43488 55771623
Coronary artery disease 149.15 10.26 586 476370 30210 55784901
Urticaria 145.43 10.26 680 476276 143996 55671115
Pregnancy 143.82 10.26 50 476906 32983 55782128
Ventricular tachycardia 142.01 10.26 388 476568 16513 55798598
Injection site pruritus 140.40 10.26 91 476865 41840 55773271
Headache 140.15 10.26 3637 473319 555407 55259704
Sopor 139.17 10.26 442 476514 20480 55794631
C-reactive protein abnormal 137.35 10.26 70 476886 36739 55778372
Transfusion 135.88 10.26 332 476624 13188 55801923
Asthenia 135.16 10.26 3833 473123 339140 55475971
Shock haemorrhagic 133.31 10.26 259 476697 8774 55806337
Epistaxis 132.79 10.26 998 475958 66025 55749086
Blood potassium decreased 131.35 10.26 662 476294 38010 55777101
Acute respiratory failure 129.82 10.26 564 476392 30430 55784681
Orthopnoea 129.47 10.26 200 476756 5616 55809495
Red blood cell sedimentation rate abnormal 129.41 10.26 7 476949 18666 55796445
Presyncope 128.96 10.26 493 476463 25089 55790022
Sedation complication 128.54 10.26 297 476659 11375 55803736
Blood calcium decreased 127.25 10.26 467 476489 23302 55791809
Blister 124.63 10.26 487 476469 108400 55706711
Knee arthroplasty 122.96 10.26 116 476840 44143 55770968
Subdural haematoma 122.62 10.26 319 476637 13180 55801931
Blood pressure decreased 122.52 10.26 889 476067 58161 55756950
Cardiac disorder 121.98 10.26 735 476221 45152 55769959
Sleep disorder 120.98 10.26 244 476712 67419 55747692
Cardiogenic shock 120.82 10.26 358 476598 15967 55799144
Toxic epidermal necrolysis 120.48 10.26 436 476520 21606 55793505
Anuria 119.49 10.26 290 476666 11470 55803641
Cardiomegaly 118.92 10.26 358 476598 16109 55799002
Oliguria 118.52 10.26 237 476719 8203 55806908
Hepatic failure 117.11 10.26 578 476378 32908 55782203
Injection site bruising 116.68 10.26 93 476863 38428 55776683
Red blood cell sedimentation rate increased 116.59 10.26 84 476872 36539 55778572
Pericardial effusion 115.73 10.26 497 476459 26678 55788433
Blood potassium increased 115.12 10.26 365 476591 16896 55798215
Loss of personal independence in daily activities 114.23 10.26 333 476623 81036 55734075
Cerebrovascular accident 112.20 10.26 1311 475645 97959 55717152
Mitral valve incompetence 111.29 10.26 373 476583 17780 55797331
Hypernatraemia 110.38 10.26 200 476756 6420 55808691
Hypomagnesaemia 109.24 10.26 461 476495 24554 55790557
Sepsis 109.22 10.26 1728 475228 138112 55676999
Hypovolaemia 108.62 10.26 249 476707 9486 55805625
Cardiac arrest 107.11 10.26 1161 475795 85153 55729958
Pseudo-Bartter syndrome 105.94 10.26 35 476921 40 55815071
Renal injury 105.52 10.26 233 476723 8654 55806457
Drug abuse 104.44 10.26 264 476692 67346 55747765
Haematemesis 103.86 10.26 501 476455 28257 55786854
Hypocalcaemia 103.13 10.26 500 476456 28260 55786851
Acute pulmonary oedema 100.36 10.26 208 476748 7389 55807722
Brain natriuretic peptide increased 100.31 10.26 159 476797 4567 55810544
Adverse drug reaction 99.31 10.26 256 476700 64876 55750235
Atrial flutter 97.35 10.26 230 476726 8939 55806172
Migraine 96.91 10.26 392 476564 86405 55728706
Nephrocalcinosis 96.03 10.26 75 476881 940 55814171
Hyperuricaemia 94.61 10.26 161 476795 4912 55810199
Cellulitis 94.31 10.26 1011 475945 73938 55741173
Bradyarrhythmia 92.86 10.26 99 476857 1897 55813214
Toxic skin eruption 92.22 10.26 263 476693 11476 55803635
Blood loss anaemia 91.23 10.26 211 476745 8086 55807025
Blood bilirubin increased 91.04 10.26 538 476418 32816 55782295
Blood sodium decreased 90.93 10.26 403 476553 21931 55793180
Cardiomyopathy 90.05 10.26 323 476633 15935 55799176
Electrolyte imbalance 89.64 10.26 346 476610 17687 55797424
Balance disorder 88.88 10.26 1016 475940 75504 55739607
N-terminal prohormone brain natriuretic peptide increased 88.61 10.26 93 476863 1749 55813362
Gout 86.66 10.26 264 476692 11957 55803154
Ventricular fibrillation 86.66 10.26 246 476710 10706 55804405
Oxygen saturation decreased 86.59 10.26 1038 475918 78029 55737082
Atrioventricular block complete 86.19 10.26 194 476762 7300 55807811
Multiple sclerosis relapse 85.43 10.26 156 476800 44747 55770364
Hypochloraemia 85.16 10.26 88 476868 1624 55813487
Liver injury 84.52 10.26 140 476816 41708 55773403
Respiratory distress 83.37 10.26 506 476450 31161 55783950
Paraesthesia 81.85 10.26 709 476247 129805 55685306
Night sweats 81.28 10.26 140 476816 41073 55774038
Lower gastrointestinal haemorrhage 80.38 10.26 184 476772 7003 55808108
Atrioventricular block 80.01 10.26 179 476777 6708 55808403
Blood alkaline phosphatase increased 78.87 10.26 583 476373 38362 55776749
Accidental exposure to product 77.84 10.26 57 476899 24590 55790521
Arrhythmia 77.31 10.26 536 476420 34547 55780564
Rheumatoid nodule 76.89 10.26 16 476940 14841 55800270
Pruritus 76.66 10.26 2069 474887 314554 55500557
Colitis ulcerative 76.27 10.26 57 476899 24334 55790777
Hypovolaemic shock 75.59 10.26 151 476805 5222 55809889
Glomerular filtration rate decreased 75.28 10.26 253 476703 12076 55803035
Chest pain 74.81 10.26 2122 474834 187675 55627436
Iron deficiency anaemia 73.45 10.26 324 476632 17595 55797516
Ischaemic stroke 73.24 10.26 310 476646 16532 55798579
Pulmonary arterial pressure increased 72.88 10.26 115 476841 3290 55811821
Drug tolerance decreased 72.46 10.26 13 476943 13398 55801713
Drug resistance 72.36 10.26 42 476914 20500 55794611
Pemphigoid 72.35 10.26 163 476793 6137 55808974
Sudden death 72.10 10.26 212 476744 9413 55805698
Upper gastrointestinal haemorrhage 71.15 10.26 310 476646 16744 55798367
Joint stiffness 71.09 10.26 119 476837 35306 55779805
Haemodialysis 70.95 10.26 196 476760 8395 55806716
Type 2 diabetes mellitus 70.82 10.26 185 476771 46677 55768434
Tenosynovitis 69.71 10.26 11 476945 12450 55802661
Prothrombin time prolonged 69.26 10.26 201 476755 8859 55806252
Live birth 69.18 10.26 40 476916 19565 55795546
Haemoptysis 69.03 10.26 423 476533 26137 55788974
Shock 68.27 10.26 364 476592 21364 55793747
Suicidal ideation 68.14 10.26 255 476701 57487 55757624
Renal disorder 68.03 10.26 457 476499 29148 55785963
Hypoaesthesia 67.93 10.26 819 476137 140672 55674439
Blood cholesterol increased 67.76 10.26 350 476606 72229 55742882
Inappropriate schedule of product administration 67.65 10.26 421 476535 82966 55732145
Rales 67.57 10.26 224 476732 10616 55804495
Left ventricular failure 67.42 10.26 138 476818 4858 55810253
Cerebral haemorrhage 67.19 10.26 444 476512 28162 55786949
Impaired work ability 67.07 10.26 20 476936 14552 55800559
Foot deformity 66.70 10.26 62 476894 23763 55791348
Nausea 66.65 10.26 5574 471382 758604 55056507
Prerenal failure 66.11 10.26 74 476882 1501 55813610
Intra-abdominal haematoma 65.77 10.26 76 476880 1598 55813513
Adverse event 64.41 10.26 246 476710 55130 55759981
Pulmonary congestion 64.26 10.26 289 476667 15826 55799285
Foetal exposure during pregnancy 63.90 10.26 118 476838 33705 55781406
Inflammation 63.41 10.26 335 476621 68736 55746375
Dialysis 62.73 10.26 203 476753 9499 55805612
Muscle spasticity 61.95 10.26 47 476909 19913 55795198
Therapeutic response decreased 60.95 10.26 235 476721 52523 55762588
Congestive cardiomyopathy 60.73 10.26 145 476811 5674 55809437
Drug ineffective for unapproved indication 60.69 10.26 77 476879 25616 55789495
Cardiac output decreased 60.52 10.26 55 476901 860 55814251
Grip strength decreased 60.52 10.26 31 476925 16225 55798886
Pneumonia aspiration 60.48 10.26 476 476480 31935 55783176
Muscle haemorrhage 60.28 10.26 98 476858 2877 55812234
Intentional self-injury 59.97 10.26 74 476882 24918 55790193
Bone erosion 59.67 10.26 26 476930 14948 55800163
Ejection fraction decreased 59.37 10.26 328 476628 19513 55795598
Congestive hepatopathy 59.33 10.26 90 476866 2486 55812625
Haematuria 59.28 10.26 412 476544 26575 55788536
Hepatic function abnormal 58.80 10.26 497 476459 34061 55781050
Loss of consciousness 58.72 10.26 1275 475681 108074 55707037
Cor pulmonale 58.62 10.26 78 476878 1903 55813208
Cognitive disorder 58.23 10.26 655 476301 48478 55766633
Ischaemic cardiomyopathy 58.17 10.26 85 476871 2269 55812842
Aortic stenosis 57.95 10.26 120 476836 4260 55810851
Oral herpes 57.91 10.26 65 476891 22825 55792286
Febrile neutropenia 57.75 10.26 593 476363 104952 55710159
Anaphylactic reaction 57.64 10.26 280 476676 58715 55756396
Azotaemia 57.47 10.26 116 476840 4042 55811069
Confusional state 57.30 10.26 2231 474725 205924 55609187
Acne 56.85 10.26 57 476899 21079 55794032
Musculoskeletal pain 56.76 10.26 428 476528 80724 55734387
Metabolic acidosis 56.25 10.26 557 476399 39897 55775214
No adverse event 56.19 10.26 142 476814 36232 55778879
Injection site warmth 54.78 10.26 26 476930 14217 55800894
Tricuspid valve incompetence 54.60 10.26 240 476716 13013 55802098
Abdominal wall haematoma 54.52 10.26 90 476866 2677 55812434
Concomitant disease aggravated 54.21 10.26 176 476780 8250 55806861
Arteriosclerosis coronary artery 53.84 10.26 167 476789 7638 55807473
Injection site rash 53.84 10.26 39 476917 16919 55798192
Infective pulmonary exacerbation of cystic fibrosis 53.72 10.26 4 476952 8153 55806958
Sedation 53.47 10.26 490 476466 34364 55780747
COVID-19 53.38 10.26 394 476562 74664 55740447
Renal tubular necrosis 52.39 10.26 206 476750 10622 55804489
Breast cancer 52.34 10.26 224 476732 48609 55766502
Aspartate aminotransferase increased 51.92 10.26 986 475970 81616 55733495
Coeliac disease 51.75 10.26 12 476944 10327 55804784
Multiple sclerosis 51.64 10.26 98 476858 27704 55787407
Basal cell carcinoma 51.28 10.26 84 476872 25137 55789974
Injection site urticaria 51.25 10.26 22 476934 12761 55802350
Disability 50.48 10.26 36 476920 15744 55799367
Gestational diabetes 50.26 10.26 5 476951 8059 55807052
Ovarian cyst 50.12 10.26 32 476924 14834 55800277
Dilatation ventricular 50.09 10.26 79 476877 2259 55812852
Pyrexia 50.08 10.26 2971 473985 415802 55399309
Faeces discoloured 49.55 10.26 279 476677 16717 55798394
Insomnia 49.20 10.26 1243 475713 190617 55624494
Catheter management 49.19 10.26 87 476869 2739 55812372
Device difficult to use 49.11 10.26 15 476941 10746 55804365
Coagulopathy 48.59 10.26 298 476658 18418 55796693
Joint range of motion decreased 48.36 10.26 88 476868 25277 55789834
Jaundice 48.29 10.26 396 476560 26898 55788213
Cardiac pacemaker insertion 48.00 10.26 102 476854 3688 55811423
Encephalopathy 47.96 10.26 484 476472 34841 55780270
Enthesopathy 47.73 10.26 6 476950 8057 55807054
Oxygen consumption increased 47.48 10.26 99 476857 3532 55811579
International normalised ratio abnormal 46.96 10.26 88 476868 2900 55812211
Therapeutic response shortened 46.77 10.26 11 476945 9375 55805736
Fibromyalgia 46.76 10.26 304 476652 59299 55755812
Psychotic disorder 46.47 10.26 80 476876 23478 55791633
International normalised ratio decreased 46.45 10.26 107 476849 4089 55811022
Nodal rhythm 46.40 10.26 63 476893 1568 55813543
Aortic valve incompetence 46.31 10.26 128 476828 5484 55809627
Septic shock 46.04 10.26 748 476208 60087 55755024
Arthritis 46.01 10.26 583 476373 99269 55715842
Platelet count decreased 46.01 10.26 1204 475752 105179 55709932
Maternal exposure before pregnancy 45.94 10.26 3 476953 6820 55808291
Myocardial ischaemia 45.87 10.26 214 476742 11902 55803209
Sinus node dysfunction 45.75 10.26 110 476846 4324 55810787
Disorientation 45.63 10.26 493 476463 36120 55778991
Head injury 45.60 10.26 366 476590 24700 55790411
Cardio-respiratory arrest 45.58 10.26 690 476266 54631 55760480
Polyuria 45.26 10.26 154 476802 7397 55807714
Bone density decreased 45.07 10.26 26 476930 12734 55802377
Hyponatraemic syndrome 44.68 10.26 37 476919 507 55814604
Ecchymosis 44.55 10.26 190 476766 10166 55804945
Diabetes mellitus inadequate control 44.46 10.26 235 476721 13745 55801366
Peripartum cardiomyopathy 44.44 10.26 23 476933 130 55814981
Sinus bradycardia 44.33 10.26 230 476726 13356 55801755
Gastrointestinal tract mucosal pigmentation 43.91 10.26 38 476918 555 55814556
Decreased appetite 43.73 10.26 2274 474682 216957 55598154
Subcutaneous haematoma 43.57 10.26 60 476896 1514 55813597
Wrong technique in product usage process 43.47 10.26 301 476655 57867 55757244
Blood parathyroid hormone decreased 43.30 10.26 9 476947 8355 55806756
Ankylosing spondylitis 43.28 10.26 15 476941 9915 55805196
Intestinal haemorrhage 43.27 10.26 94 476862 3452 55811659
Progressive multifocal leukoencephalopathy 43.12 10.26 24 476932 11989 55803122
Coronary arterial stent insertion 42.82 10.26 80 476876 2630 55812481
Bursitis 42.35 10.26 108 476848 27474 55787637
Osteoarthritis 42.35 10.26 455 476501 79841 55735270
Exercise tolerance decreased 42.21 10.26 117 476839 5021 55810090
Myopathy 42.19 10.26 180 476776 9632 55805479
Lip dry 41.96 10.26 15 476941 9725 55805386
Unevaluable event 41.72 10.26 601 476355 47086 55768025
Hyperglycaemia 41.65 10.26 502 476454 37779 55777332
Cholestasis 41.61 10.26 379 476577 26534 55788577
Colitis microscopic 41.54 10.26 154 476802 7721 55807390
Depression 40.95 10.26 1187 475769 178930 55636181
Fear of injection 40.71 10.26 4 476952 6511 55808600
Myoclonus 40.70 10.26 244 476712 14959 55800152
Uterine perforation 40.63 10.26 4 476952 6501 55808610
Device issue 40.44 10.26 73 476883 21033 55794078
Pharyngitis 40.31 10.26 59 476897 18479 55796632
Lupus-like syndrome 40.21 10.26 28 476928 12399 55802712
Oropharyngeal pain 40.19 10.26 485 476471 83303 55731808
Bundle branch block left 40.13 10.26 132 476824 6230 55808881
Jugular vein distension 40.13 10.26 43 476913 829 55814282
Concomitant disease progression 40.05 10.26 67 476889 2015 55813096
Angina unstable 39.91 10.26 138 476818 6683 55808428
Hypercapnia 39.86 10.26 114 476842 4982 55810129
Prothrombin time shortened 39.51 10.26 61 476895 1712 55813399
Dilatation atrial 39.48 10.26 63 476893 1820 55813291
Microcytic anaemia 39.20 10.26 85 476871 3117 55811994
Mucosal inflammation 39.08 10.26 208 476748 42602 55772509
Gravitational oedema 39.05 10.26 49 476907 1126 55813985
Asthma 39.02 10.26 696 476260 112074 55703037
Dermatitis exfoliative 39.01 10.26 116 476840 5183 55809928
Acidosis 38.68 10.26 184 476772 10317 55804794
Uveitis 38.63 10.26 23 476933 11072 55804039
Haemorrhage 38.51 10.26 682 476274 55715 55759396
Lethargy 38.36 10.26 631 476325 50810 55764301
Mental status changes 38.31 10.26 486 476470 37015 55778096
Poor venous access 38.16 10.26 29 476927 12277 55802834
Activated partial thromboplastin time prolonged 38.02 10.26 133 476823 6479 55808632
Blood albumin decreased 37.95 10.26 221 476735 13407 55801704
Hepatic cirrhosis 37.88 10.26 309 476647 20954 55794157
Haematotoxicity 37.69 10.26 12 476944 8371 55806740
Dystonia 37.60 10.26 30 476926 12391 55802720
Immunodeficiency 37.56 10.26 49 476907 16108 55799003
Hypoglycaemic coma 37.56 10.26 70 476886 2297 55812814
Acute coronary syndrome 37.33 10.26 173 476783 9595 55805516
Petechiae 37.32 10.26 213 476743 12826 55802285
Blood uric acid increased 37.25 10.26 99 476857 4143 55810968
Nephrotic syndrome 37.12 10.26 114 476842 5186 55809925
Hypercreatininaemia 37.10 10.26 29 476927 364 55814747
Ventricular arrhythmia 37.06 10.26 87 476869 3367 55811744
Tendonitis 37.05 10.26 60 476896 18037 55797074
Anxiety 36.49 10.26 1304 475652 191868 55623243
Oesophageal varices haemorrhage 36.47 10.26 45 476911 1016 55814095
Coronary artery bypass 36.41 10.26 68 476888 2235 55812876
Panniculitis 36.29 10.26 19 476937 9823 55805288
Atrioventricular block first degree 36.27 10.26 133 476823 6632 55808479
Pneumonia viral 36.11 10.26 138 476818 7020 55808091
Condition aggravated 36.00 10.26 2477 474479 342421 55472690
Mood swings 35.73 10.26 54 476902 16693 55798418
Facet joint syndrome 35.25 10.26 7 476949 6710 55808401
Cardiac valve disease 35.05 10.26 93 476863 3888 55811223
Drug reaction with eosinophilia and systemic symptoms 35.00 10.26 402 476554 29902 55785209
Chronic respiratory failure 34.68 10.26 57 476899 1689 55813422
Ischaemic hepatitis 34.41 10.26 61 476895 1924 55813187
Ear infection 33.87 10.26 143 476813 31152 55783959
Electrocardiogram ST segment abnormal 33.76 10.26 41 476915 910 55814201
Breast cancer stage I 33.74 10.26 6 476950 6224 55808887
Tachypnoea 33.55 10.26 235 476721 15195 55799916
Acute generalised exanthematous pustulosis 33.54 10.26 169 476787 9700 55805411
Schizophrenia 33.52 10.26 24 476932 10475 55804636
Ventricular dysfunction 33.45 10.26 72 476884 2627 55812484
Catheter site infection 33.41 10.26 99 476857 4415 55810696
Pallor 33.32 10.26 332 476624 23817 55791294
Product quality issue 33.14 10.26 147 476809 31589 55783522
Product dose omission issue 33.04 10.26 1408 475548 203345 55611766
Osteoporosis 32.95 10.26 282 476674 51770 55763341
Cerebral haematoma 32.75 10.26 81 476875 3242 55811869
Heparin-induced thrombocytopenia 32.70 10.26 94 476862 4120 55810991
Disease recurrence 32.49 10.26 99 476857 23761 55791350
Agranulocytosis 32.48 10.26 314 476642 22345 55792766
Influenza like illness 32.39 10.26 345 476611 60643 55754468
Bundle branch block right 32.22 10.26 101 476855 4646 55810465
Throat irritation 31.99 10.26 155 476801 32528 55782583
Dermatitis bullous 31.85 10.26 138 476818 7435 55807676
Immune reconstitution inflammatory syndrome 31.76 10.26 5 476951 5669 55809442
Scleroderma 31.76 10.26 104 476852 4897 55810214
Haemorrhage subcutaneous 31.49 10.26 72 476884 2738 55812373
Alkalosis hypochloraemic 31.44 10.26 18 476938 128 55814983
Inferior vena cava dilatation 31.27 10.26 15 476941 70 55815041
Breast cancer female 31.25 10.26 35 476921 12303 55802808
Eosinophilia 31.17 10.26 283 476673 19794 55795317
Blood glucose decreased 31.15 10.26 272 476684 18815 55796296
Medication error 31.09 10.26 518 476438 41817 55773294
Cyanosis 31.05 10.26 235 476721 15575 55799536
Change of bowel habit 30.95 10.26 60 476896 2029 55813082
Angina pectoris 30.93 10.26 368 476588 27608 55787503
Abdominal distension 30.84 10.26 869 476087 76757 55738354
Device dislocation 30.64 10.26 94 476862 22512 55792599
Eye pain 30.36 10.26 146 476810 30701 55784410
Device use error 30.11 10.26 5 476951 5451 55809660
Nodule 30.08 10.26 71 476885 18548 55796563
Fear 30.08 10.26 223 476733 14685 55800426
Venous pressure jugular increased 29.94 10.26 30 476926 533 55814578
Ventricular hypertrophy 29.90 10.26 77 476879 3161 55811950
Soft tissue disorder 29.89 10.26 92 476864 4190 55810921
Protein total decreased 29.87 10.26 107 476849 5275 55809836
Maternal exposure timing unspecified 29.86 10.26 5 476951 5418 55809693
Bradyphrenia 29.68 10.26 123 476833 6497 55808614
Vital capacity decreased 29.67 10.26 45 476911 1243 55813868
Dry eye 29.64 10.26 179 476777 35537 55779574
Multiple drug therapy 29.60 10.26 70 476886 2722 55812389
Urinary tract discomfort 29.58 10.26 24 476932 319 55814792
Nasal congestion 29.52 10.26 655 476301 55715 55759396
Retroperitoneal haematoma 29.50 10.26 69 476887 2664 55812447
Vascular purpura 29.46 10.26 46 476910 1304 55813807
Hypophagia 29.40 10.26 374 476582 28502 55786609
Ear pain 29.37 10.26 148 476808 30742 55784369
Occult blood positive 29.22 10.26 78 476878 3273 55811838
Circulatory collapse 29.19 10.26 287 476669 20516 55794595
Menstruation irregular 29.04 10.26 9 476947 6387 55808724
Renal artery stenosis 29.04 10.26 54 476902 1769 55813342
Liver function test increased 28.96 10.26 131 476825 28002 55787109
Impaired quality of life 28.90 10.26 18 476938 8456 55806655
Right-to-left cardiac shunt 28.70 10.26 21 476935 237 55814874
Incorrect route of product administration 28.69 10.26 89 476867 21240 55793871
Nephrogenic anaemia 28.59 10.26 55 476901 1849 55813262
Anhedonia 28.41 10.26 162 476794 9752 55805359
Haemorrhoidal haemorrhage 28.29 10.26 86 476870 3890 55811221
Neutropenia 28.23 10.26 1075 475881 157092 55658019
Oxygen therapy 28.21 10.26 55 476901 1868 55813243
Breast cancer stage II 28.20 10.26 7 476949 5751 55809360
Decubitus ulcer 28.19 10.26 160 476796 9615 55805496
Amenorrhoea 28.09 10.26 21 476935 8965 55806146
Troponin increased 28.04 10.26 146 476810 8489 55806622
Paracentesis 28.01 10.26 37 476919 896 55814215
Sinus arrest 27.72 10.26 52 476904 1715 55813396
Basilar artery occlusion 27.61 10.26 15 476941 95 55815016
Liver function test abnormal 27.61 10.26 542 476414 45129 55769982
Right atrial dilatation 27.53 10.26 30 476926 590 55814521
Complication of device insertion 27.49 10.26 10 476946 6414 55808697
Alkalosis 27.49 10.26 23 476933 320 55814791
Pulmonary alveolar haemorrhage 27.37 10.26 89 476867 4175 55810936
Blood creatinine abnormal 27.24 10.26 68 476888 2738 55812373
Extrasystoles 27.14 10.26 96 476860 4703 55810408
Catheter site erythema 27.08 10.26 86 476870 3984 55811127
Haemorrhage intracranial 27.00 10.26 193 476763 12562 55802549
Urinary tract infection 26.90 10.26 2377 474579 238136 55576975
Gastritis erosive 26.90 10.26 106 476850 5471 55809640
Blood chloride decreased 26.84 10.26 102 476854 5175 55809936
Metabolic encephalopathy 26.81 10.26 102 476854 5178 55809933
Arteriosclerosis 26.78 10.26 154 476802 9299 55805812
Disseminated intravascular coagulation 26.71 10.26 250 476706 17635 55797476
Abdominal cavity drainage 26.68 10.26 24 476932 370 55814741
Pain in jaw 26.57 10.26 482 476474 39554 55775557
Pelvic pain 26.56 10.26 37 476919 11830 55803281
Central nervous system lesion 26.50 10.26 27 476929 9911 55805200
Altered state of consciousness 26.41 10.26 305 476651 22716 55792395
Musculoskeletal disorder 26.39 10.26 79 476877 19068 55796043
Cardiac operation 26.35 10.26 69 476887 2862 55812249
Anticoagulation drug level above therapeutic 26.33 10.26 42 476914 1213 55813898
Blood creatine increased 26.32 10.26 100 476856 5073 55810038
Tooth infection 26.31 10.26 59 476897 15693 55799418
Cardiac murmur 26.19 10.26 176 476780 11225 55803886
Tachyarrhythmia 26.11 10.26 87 476869 4134 55810977
Suspected suicide 26.09 10.26 7 476949 5459 55809652
Duodenal ulcer haemorrhage 25.99 10.26 59 476897 2233 55812878
Hypoxic-ischaemic encephalopathy 25.92 10.26 83 476873 3862 55811249
Thrombocytopenia 25.73 10.26 1406 475550 134818 55680293
Wound secretion 25.39 10.26 85 476871 4049 55811062
Haematocrit decreased 25.36 10.26 446 476510 36383 55778728
Hyperglycaemic hyperosmolar nonketotic syndrome 25.30 10.26 30 476926 649 55814462
Hypoalbuminaemia 25.18 10.26 165 476791 10434 55804677
Pregnancy with contraceptive device 25.16 10.26 3 476953 4196 55810915
Blood pressure inadequately controlled 25.15 10.26 90 476866 4434 55810677
Staphylococcal sepsis 25.08 10.26 126 476830 7223 55807888
Pre-eclampsia 25.06 10.26 21 476935 8465 55806646
Haemorrhagic diathesis 25.05 10.26 84 476872 4004 55811107
Pain in extremity 24.91 10.26 2175 474781 295256 55519855
Nodal arrhythmia 24.91 10.26 39 476917 1108 55814003
Aspiration pleural cavity 24.89 10.26 32 476924 754 55814357
Ulcer 24.80 10.26 102 476854 22383 55792728
Nephrosclerosis 24.66 10.26 36 476920 960 55814151
Neck pain 24.55 10.26 370 476586 61185 55753926
Atrial enlargement 24.53 10.26 21 476935 302 55814809
Tunnel vision 24.53 10.26 33 476923 814 55814297
Peritonitis bacterial 24.50 10.26 92 476864 4641 55810470
Lymphoedema 24.46 10.26 163 476793 10367 55804744
Interstitial lung disease 24.42 10.26 645 476311 56418 55758693
Transient ischaemic attack 24.34 10.26 410 476546 33167 55781944
Mitral valve stenosis 24.21 10.26 38 476918 1082 55814029
Brain natriuretic peptide 24.19 10.26 10 476946 30 55815081
Pericardial haemorrhage 24.18 10.26 45 476911 1475 55813636
Catheter site pruritus 24.17 10.26 53 476903 1959 55813152
Product storage error 24.16 10.26 47 476909 13166 55801945
Alveolar osteitis 24.11 10.26 27 476929 548 55814563
Injection site mass 24.09 10.26 68 476888 16725 55798386
Joint dislocation 24.03 10.26 62 476894 15711 55799400
Premature labour 23.76 10.26 40 476916 11842 55803269
Hyperaesthesia 23.68 10.26 23 476933 8634 55806477
Intentional product misuse 23.61 10.26 301 476655 51203 55763908
Seizure 23.52 10.26 845 476111 124274 55690837
Synovial cyst 23.49 10.26 26 476930 9188 55805923
Hepatitis fulminant 23.46 10.26 70 476886 3134 55811977
Prescribed overdose 23.45 10.26 103 476853 22193 55792918
Sputum culture positive 23.42 10.26 48 476908 1691 55813420
Walking distance test abnormal 23.36 10.26 26 476930 524 55814587
Reversible airways obstruction 23.31 10.26 42 476914 1342 55813769
Ventricular extrasystoles 23.31 10.26 165 476791 10705 55804406
Macular degeneration 23.29 10.26 82 476874 18826 55796285
Catheter placement 23.27 10.26 54 476902 2074 55813037
Carbon dioxide increased 23.19 10.26 39 476917 1178 55813933
Blood glucose increased 23.18 10.26 816 476140 74335 55740776
Urine odour abnormal 23.16 10.26 105 476851 5769 55809342
Irritability 23.16 10.26 151 476805 29437 55785674
Tetany 23.14 10.26 47 476909 1645 55813466
Lung transplant 23.12 10.26 66 476890 2881 55812230
Catheter site discharge 23.03 10.26 50 476906 1835 55813276
Heavy menstrual bleeding 22.98 10.26 66 476890 16143 55798968
Blood iron decreased 22.76 10.26 184 476772 12443 55802668
Dyspnoea paroxysmal nocturnal 22.75 10.26 32 476924 824 55814287
Cerebral infarction 22.70 10.26 291 476665 22214 55792897
Drug level increased 22.64 10.26 272 476684 20453 55794658
Gamma-glutamyltransferase increased 22.63 10.26 379 476577 30626 55784485
Laryngitis 22.60 10.26 53 476903 13877 55801234
Marasmus 22.59 10.26 24 476932 458 55814653
Hospitalisation 22.55 10.26 812 476144 74188 55740923
Abdominal pain upper 22.51 10.26 1258 475698 177055 55638056
Metastases to bone 22.46 10.26 87 476869 19421 55795690
Hepatotoxicity 22.40 10.26 163 476793 30990 55784121
Gastric disorder 22.34 10.26 177 476779 33033 55782078
Dyspnoea at rest 22.19 10.26 77 476879 3736 55811375
Volume blood decreased 22.12 10.26 14 476942 122 55814989
Therapy partial responder 22.10 10.26 20 476936 7765 55807346
Catheterisation cardiac 22.05 10.26 83 476873 4192 55810919
Bronchitis 21.96 10.26 1163 475793 111148 55703963
Deformity 21.94 10.26 33 476923 10222 55804889
Hepatojugular reflux 21.91 10.26 8 476948 15 55815096
Renal atrophy 21.86 10.26 41 476915 1352 55813759
Cardiac cirrhosis 21.83 10.26 14 476942 125 55814986
Constipation 21.83 10.26 1991 474965 199952 55615159
Haemorrhagic disorder 21.79 10.26 31 476925 807 55814304
Visual impairment 21.70 10.26 471 476485 73731 55741380
Ureteric rupture 21.66 10.26 7 476949 7 55815104
Nephropathy toxic 21.65 10.26 135 476821 8392 55806719
Dermatitis atopic 21.62 10.26 23 476933 8276 55806835
Diastolic dysfunction 21.59 10.26 100 476856 5545 55809566
Nail disorder 21.58 10.26 40 476916 11411 55803700
Photophobia 21.57 10.26 67 476889 15983 55799128
Hypothermia 21.56 10.26 180 476776 12290 55802821
Bilirubin conjugated increased 21.54 10.26 59 476897 2514 55812597
Adverse reaction 21.50 10.26 29 476927 9398 55805713
Cardiac hypertrophy 21.44 10.26 34 476922 977 55814134
Respiratory acidosis 21.27 10.26 106 476850 6057 55809054
Affect lability 21.26 10.26 33 476923 10092 55805019
Gouty arthritis 21.26 10.26 25 476931 536 55814575
Urosepsis 21.25 10.26 226 476730 16490 55798621
Atrial septal defect repair 21.20 10.26 17 476939 222 55814889
Exposure to toxic agent 21.14 10.26 3 476953 3675 55811436
Complication of device removal 21.06 10.26 6 476950 4498 55810613
Ovarian hyperstimulation syndrome 21.04 10.26 3 476953 3661 55811450
Hyperprolactinaemia 21.01 10.26 3 476953 3658 55811453
Maternal exposure during breast feeding 20.91 10.26 3 476953 3644 55811467
Device related infection 20.85 10.26 280 476676 21600 55793511
Temperature regulation disorder 20.81 10.26 6 476950 4462 55810649
Hepatorenal syndrome 20.80 10.26 47 476909 1773 55813338
Blood sodium increased 20.78 10.26 57 476899 2431 55812680
Polyarthritis 20.78 10.26 26 476930 8702 55806409
Pancytopenia 20.77 10.26 935 476021 87780 55727331
Injection site haemorrhage 20.75 10.26 107 476849 22094 55793017
Burning sensation 20.72 10.26 289 476667 48407 55766704
Upper respiratory tract infection 20.71 10.26 453 476503 70835 55744276
Mixed liver injury 20.69 10.26 77 476879 3867 55811244
Malignant neoplasm progression 20.69 10.26 470 476486 73117 55741994
Hypertrophic cardiomyopathy 20.65 10.26 40 476916 1352 55813759
Myelosuppression 20.64 10.26 77 476879 17378 55797733
Malaise 20.63 10.26 3481 473475 364379 55450732
Hepatorenal failure 20.60 10.26 26 476930 601 55814510
Skin turgor decreased 20.57 10.26 23 476933 466 55814645
Eye irritation 20.56 10.26 87 476869 18941 55796170
Hypercalciuria 20.52 10.26 18 476938 268 55814843
Hypochromic anaemia 20.49 10.26 47 476909 1791 55813320
Peripheral embolism 20.41 10.26 36 476920 1131 55813980
Atrial tachycardia 20.39 10.26 53 476903 2188 55812923
Tuberculosis 20.37 10.26 39 476917 10990 55804121
Continuous haemodiafiltration 20.37 10.26 33 476923 966 55814145
Gastric haemorrhage 20.30 10.26 102 476854 5848 55809263
Staphylococcus test positive 20.19 10.26 72 476884 3541 55811570
Pickwickian syndrome 20.16 10.26 19 476937 312 55814799
Right ventricular dysfunction 20.09 10.26 44 476912 1625 55813486
Palpitations 20.07 10.26 1035 475921 98637 55716474
Erythromelalgia 20.01 10.26 13 476943 119 55814992
Bronchial secretion retention 19.98 10.26 47 476909 1821 55813290
Blood pressure fluctuation 19.97 10.26 232 476724 40128 55774983
BRASH syndrome 19.93 10.26 18 476938 279 55814832
Low cardiac output syndrome 19.93 10.26 18 476938 279 55814832
Vascular device infection 19.90 10.26 97 476859 5493 55809618
Traumatic haematoma 19.85 10.26 39 476917 1332 55813779
Poisoning 19.80 10.26 50 476906 12763 55802348
Blood creatine phosphokinase increased 19.78 10.26 340 476616 27612 55787499
Cardiac amyloidosis 19.74 10.26 29 476927 778 55814333
Nephropathy 19.73 10.26 97 476859 5512 55809599
Gouty tophus 19.73 10.26 14 476942 150 55814961
Frequent bowel movements 19.72 10.26 72 476884 16352 55798759
Caesarean section 19.68 10.26 70 476886 16021 55799090
Asterixis 19.66 10.26 36 476920 1165 55813946
Glomerulonephritis acute 19.65 10.26 9 476947 37 55815074
Therapy non-responder 19.56 10.26 384 476572 60971 55754140
Haematoma muscle 19.55 10.26 32 476924 945 55814166
Hyperamylasaemia 19.53 10.26 20 476936 365 55814746
Right ventricular enlargement 19.52 10.26 18 476938 287 55814824
Ulcer haemorrhage 19.49 10.26 70 476886 3455 55811656
Left ventricular dysfunction 19.47 10.26 161 476795 10962 55804149
Hallucination 19.46 10.26 550 476406 48599 55766512
Internal haemorrhage 19.42 10.26 86 476870 4678 55810433
Product complaint 19.41 10.26 168 476788 11592 55803519
Nightmare 19.40 10.26 75 476881 16751 55798360
Ocular hyperaemia 19.39 10.26 108 476848 21871 55793240
Serotonin syndrome 19.33 10.26 138 476818 26352 55788759
Neuropathy peripheral 19.31 10.26 695 476261 102198 55712913
Body temperature increased 19.29 10.26 191 476765 34051 55781060
Therapeutic embolisation 19.28 10.26 14 476942 156 55814955
Hepatocellular carcinoma 19.23 10.26 54 476902 2335 55812776
Scleritis 19.20 10.26 4 476952 3707 55811404
Demyelination 19.11 10.26 15 476941 6247 55808864
Pharyngitis streptococcal 18.97 10.26 32 476924 9466 55805645
Paraesthesia oral 18.94 10.26 61 476895 14388 55800723
Sexual dysfunction 18.93 10.26 3 476953 3385 55811726
Crohn's disease 18.86 10.26 16 476940 6411 55808700
Malignant melanoma 18.86 10.26 39 476917 10680 55804431
Optic ischaemic neuropathy 18.84 10.26 33 476923 1031 55814080
Stillbirth 18.82 10.26 15 476941 6199 55808912
Mucosal dryness 18.69 10.26 55 476901 2443 55812668
Blood urea abnormal 18.63 10.26 25 476931 615 55814496
Duodenal ulcer 18.62 10.26 114 476842 7041 55808070
Fungal infection 18.60 10.26 184 476772 32809 55782302
Endocarditis 18.58 10.26 93 476863 5323 55809788
Intestinal pseudo-obstruction 18.58 10.26 28 476928 769 55814342
Device deployment issue 18.55 10.26 4 476952 3620 55811491
Onychomycosis 18.52 10.26 17 476939 6555 55808556
Catheter site haemorrhage 18.48 10.26 62 476894 2956 55812155
Gastrointestinal toxicity 18.47 10.26 15 476941 6141 55808970
Sight disability 18.46 10.26 12 476944 110 55815001
Cholecystitis chronic 18.42 10.26 34 476922 9714 55805397
Diabetic hyperosmolar coma 18.41 10.26 19 476937 350 55814761
Wrong patient received product 18.39 10.26 50 476906 2121 55812990
Acute motor-sensory axonal neuropathy 18.39 10.26 17 476939 272 55814839
Pulmonary hypoplasia 18.34 10.26 17 476939 273 55814838
Ear congestion 18.34 10.26 50 476906 2125 55812986
Tubulointerstitial nephritis 18.32 10.26 219 476737 16446 55798665
End stage renal disease 18.26 10.26 101 476855 6010 55809101
Sciatica 18.26 10.26 137 476819 25873 55789238
Gastric ulcer haemorrhage 18.22 10.26 83 476873 4570 55810541
Product preparation error 18.20 10.26 9 476947 4807 55810304
Gastric varices 18.16 10.26 14 476942 172 55814939
Superinfection 18.15 10.26 50 476906 2138 55812973
Cardiopulmonary failure 18.08 10.26 67 476889 3358 55811753
Paradoxical drug reaction 18.03 10.26 5 476951 3815 55811296
Crying 18.03 10.26 107 476849 21333 55793778
Cardioversion 18.01 10.26 34 476922 1127 55813984
Hypocoagulable state 17.97 10.26 32 476924 1013 55814098
Localised oedema 17.89 10.26 87 476869 4922 55810189
Acute respiratory distress syndrome 17.87 10.26 273 476683 21653 55793458
Spontaneous haematoma 17.82 10.26 28 476928 798 55814313
Substance abuse 17.80 10.26 8 476948 4517 55810594
Rectosigmoid cancer 17.74 10.26 13 476943 147 55814964
Hiatus hernia 17.72 10.26 249 476707 19403 55795708
Mouth ulceration 17.69 10.26 163 476793 29477 55785634
Subdural haemorrhage 17.69 10.26 59 476897 2805 55812306
Peripheral arterial occlusive disease 17.63 10.26 72 476884 3778 55811333
Diabetes mellitus 17.63 10.26 578 476378 52157 55762954
Pulmonary veno-occlusive disease 17.58 10.26 32 476924 1031 55814080
Ammonia increased 17.53 10.26 78 476878 4251 55810860
Electrocardiogram repolarisation abnormality 17.49 10.26 35 476921 1212 55813899
Joint effusion 17.44 10.26 66 476890 14832 55800279
Antibiotic level above therapeutic 17.41 10.26 16 476940 254 55814857
Purging 17.37 10.26 9 476947 51 55815060
Cerebral mass effect 17.35 10.26 28 476928 817 55814294
Multiple-drug resistance 17.32 10.26 6 476950 3968 55811143
Mitral valve disease 17.32 10.26 51 476905 2266 55812845
Right ventricular dilatation 17.29 10.26 33 476923 1103 55814008
Hypokalaemic syndrome 17.23 10.26 9 476947 52 55815059
Cerebral venous thrombosis 17.16 10.26 45 476911 1868 55813243
Purpura 17.09 10.26 148 476808 10214 55804897
Mood altered 17.07 10.26 57 476899 13298 55801813
Drug monitoring procedure not performed 17.06 10.26 22 476934 520 55814591
Foetal growth restriction 17.05 10.26 21 476935 7078 55808033
Metastases to liver 16.97 10.26 110 476846 21476 55793635
Coronary artery occlusion 16.97 10.26 118 476838 7611 55807500
Wound haemorrhage 16.95 10.26 51 476905 2294 55812817
Prothrombin level decreased 16.84 10.26 22 476934 527 55814584
Cystostomy 16.83 10.26 9 476947 55 55815056
Retroperitoneal haemorrhage 16.73 10.26 55 476901 2595 55812516
Left ventricular hypertrophy 16.69 10.26 85 476871 4899 55810212
Neonatal hypocalcaemia 16.69 10.26 7 476949 22 55815089
Cardiothoracic ratio increased 16.69 10.26 7 476949 22 55815089
Hyperaldosteronism 16.69 10.26 15 476941 231 55814880
Heart valve incompetence 16.64 10.26 52 476904 2388 55812723
Cardiac rehabilitation therapy 16.57 10.26 5 476951 3 55815108
Supraventricular tachycardia 16.57 10.26 179 476777 13112 55801999
Cushingoid 16.55 10.26 23 476933 7361 55807750
Gastrointestinal angiodysplasia 16.53 10.26 19 476937 397 55814714
Tracheostomy 16.53 10.26 24 476932 637 55814474
Full blood count decreased 16.52 10.26 284 476672 23065 55792046
Lymphocyte count decreased 16.52 10.26 154 476802 27785 55787326
Mydriasis 16.50 10.26 44 476912 11027 55804084
Neutrophil count decreased 16.44 10.26 310 476646 49512 55765599
Heart transplant 16.43 10.26 20 476936 445 55814666
Tongue disorder 16.43 10.26 38 476918 9998 55805113
Bradykinesia 16.41 10.26 83 476873 4771 55810340
Catheter site pain 16.38 10.26 76 476880 4217 55810894
Infective exacerbation of chronic obstructive airways disease 16.37 10.26 32 476924 1089 55814022
Disturbance in social behaviour 16.32 10.26 3 476953 3038 55812073
Coagulation time prolonged 16.31 10.26 33 476923 1152 55813959
Finger deformity 16.28 10.26 19 476937 6558 55808553
Pulmonary arterial pressure abnormal 16.26 10.26 20 476936 450 55814661
Animal scratch 16.22 10.26 31 476925 1037 55814074
Fryns syndrome 16.19 10.26 9 476947 60 55815051
Postpericardiotomy syndrome 16.19 10.26 6 476950 12 55815099
Thyroid disorder 16.14 10.26 185 476771 13753 55801358
Bleeding varicose vein 16.13 10.26 15 476941 242 55814869
Dementia 16.12 10.26 219 476737 16939 55798172
Bundle branch block 16.07 10.26 27 476929 815 55814296
Emotional disorder 16.05 10.26 52 476904 12243 55802868
C-reactive protein increased 16.03 10.26 526 476430 78158 55736953
Vitamin B1 deficiency 15.98 10.26 16 476940 284 55814827
Transplant evaluation 15.98 10.26 31 476925 1049 55814062
Small for dates baby 15.97 10.26 5 476951 3525 55811586
Thermohypoaesthesia 15.97 10.26 11 476945 112 55814999
Haemorrhagic stroke 15.95 10.26 89 476867 5314 55809797
Limb reduction defect 15.93 10.26 18 476938 369 55814742
Uraemic encephalopathy 15.93 10.26 15 476941 246 55814865
Embolic stroke 15.89 10.26 67 476889 3566 55811545
Hypermagnesaemia 15.89 10.26 29 476927 936 55814175
Thalamic infarction 15.86 10.26 20 476936 462 55814649
Angiopathy 15.86 10.26 75 476881 4195 55810916
Optic neuritis 15.86 10.26 26 476930 7778 55807333
Coma 15.82 10.26 637 476319 59018 55756093
Extradural haematoma 15.77 10.26 39 476917 1561 55813550
Depressed mood 15.75 10.26 215 476741 36144 55778967
Brain natriuretic peptide abnormal 15.73 10.26 17 476939 331 55814780
Electrocardiogram U wave present 15.72 10.26 10 476946 88 55815023
Vascular graft 15.71 10.26 26 476930 775 55814336
Skin weeping 15.70 10.26 21 476935 515 55814596
Hot flush 15.64 10.26 290 476666 46436 55768675
Clostridial sepsis 15.63 10.26 18 476938 377 55814734
Anal abscess 15.63 10.26 8 476948 4189 55810922
Nasal mucosal erosion 15.60 10.26 9 476947 65 55815046
Joint destruction 15.56 10.26 12 476944 5043 55810068
Clostridium difficile colitis 15.54 10.26 234 476722 18504 55796607
Wound complication 15.53 10.26 60 476896 3068 55812043
Electrocardiogram QT shortened 15.49 10.26 11 476945 118 55814993
Tongue oedema 15.47 10.26 71 476885 3921 55811190
Neutropenic sepsis 15.46 10.26 71 476885 15114 55799997
Injection site induration 15.45 10.26 31 476925 8584 55806527
Stevens-Johnson syndrome 15.44 10.26 274 476682 22389 55792722
Generalised bullous fixed drug eruption 15.38 10.26 9 476947 67 55815044
Streptococcal sepsis 15.38 10.26 41 476915 1719 55813392
Diabetic nephropathy 15.34 10.26 35 476921 1329 55813782
Product prescribing error 15.33 10.26 279 476677 22907 55792204
Lung infiltration 15.31 10.26 181 476775 13557 55801554
Respiratory alkalosis 15.27 10.26 52 476904 2499 55812612
Pulmonary artery dilatation 15.26 10.26 15 476941 260 55814851
Prescribed underdose 15.24 10.26 107 476849 20510 55794601
Hallucination, visual 15.22 10.26 220 476736 17248 55797863
Blood lactate dehydrogenase increased 15.18 10.26 253 476703 20422 55794689
Normochromic normocytic anaemia 15.15 10.26 75 476881 4274 55810837
Chronic sinusitis 15.15 10.26 30 476926 8348 55806763
Galactorrhoea 15.15 10.26 7 476949 3888 55811223
Pseudoporphyria 15.13 10.26 13 476943 188 55814923
Puncture site haemorrhage 15.13 10.26 15 476941 263 55814848
Electrocardiogram ST-T segment depression 15.12 10.26 4 476952 0 55815111
X-ray abnormal 15.11 10.26 9 476947 4332 55810779
Blood potassium abnormal 15.10 10.26 49 476907 2296 55812815
Lymphorrhoea 15.07 10.26 8 476948 48 55815063
Hepatomegaly 15.07 10.26 154 476802 11121 55803990
Arteriospasm coronary 15.07 10.26 6 476950 3641 55811470
Device pacing issue 15.06 10.26 9 476947 70 55815041
Blepharospasm 15.04 10.26 5 476951 3393 55811718
Supraventricular extrasystoles 15.03 10.26 72 476884 4048 55811063
Carpal tunnel syndrome 15.02 10.26 91 476865 18053 55797058
Prothrombin time abnormal 15.02 10.26 18 476938 394 55814717
Spinal pain 15.00 10.26 51 476905 11833 55803278
Apnoea 14.99 10.26 109 476847 7133 55807978
Transcription medication error 14.96 10.26 13 476943 191 55814920
Hypoproteinaemia 14.95 10.26 43 476913 1885 55813226
Skin graft failure 14.91 10.26 10 476946 97 55815014
Lip erosion 14.89 10.26 27 476929 867 55814244
Blood aldosterone increased 14.88 10.26 12 476944 158 55814953
Stasis dermatitis 14.86 10.26 23 476933 647 55814464
Platelet dysfunction 14.83 10.26 10 476946 98 55815013
Haemodynamic instability 14.81 10.26 121 476835 8208 55806903
Mechanical ventilation 14.79 10.26 32 476924 1172 55813939
Cataract 14.78 10.26 326 476630 50921 55764190
Platelet transfusion 14.78 10.26 25 476931 759 55814352
Muscle twitching 14.77 10.26 79 476877 16163 55798948
Breast cancer metastatic 14.77 10.26 74 476882 15395 55799716
Genital haemorrhage 14.76 10.26 22 476934 6840 55808271
Hyperbilirubinaemia 14.75 10.26 142 476814 10093 55805018
Aortic valve calcification 14.70 10.26 19 476937 450 55814661
Deafness neurosensory 14.66 10.26 11 476945 4687 55810424
Craniocerebral injury 14.65 10.26 52 476904 2552 55812559
Tumour lysis syndrome 14.58 10.26 116 476840 7807 55807304
Pulmonary haemorrhage 14.57 10.26 103 476853 6680 55808431
Menstrual disorder 14.52 10.26 11 476945 4664 55810447
Poisoning deliberate 14.50 10.26 40 476916 9913 55805198
Ischaemia 14.34 10.26 75 476881 4368 55810743
Somnolence 14.30 10.26 1588 475368 161825 55653286
Haemophagocytic lymphohistiocytosis 14.30 10.26 38 476918 9534 55805577
Peripheral sensory neuropathy 14.30 10.26 23 476933 6933 55808178
Multimorbidity 14.28 10.26 20 476936 513 55814598
Pulmonary vein stenosis 14.16 10.26 9 476947 79 55815032
Catheter removal 14.12 10.26 17 476939 374 55814737
Surgery 14.10 10.26 192 476764 32294 55782817
Pericardial excision 14.05 10.26 6 476950 20 55815091
Vaginal discharge 14.01 10.26 19 476937 6144 55808967
Dysmenorrhoea 13.97 10.26 6 476950 3480 55811631
Systemic scleroderma 13.85 10.26 27 476929 917 55814194
Drug withdrawal syndrome 13.84 10.26 146 476810 25711 55789400
White blood cell count increased 13.80 10.26 486 476470 44273 55770838
Infected skin ulcer 13.68 10.26 45 476911 2124 55812987
Schizoaffective disorder 13.66 10.26 4 476952 2945 55812166
Sleep disorder due to a general medical condition 13.64 10.26 36 476920 9054 55806057
Myocardial necrosis 13.63 10.26 11 476945 145 55814966
Weight increased 13.62 10.26 1721 475235 227982 55587129
Gastric varices haemorrhage 13.58 10.26 10 476946 114 55814997
Cardiac valve replacement complication 13.57 10.26 11 476945 146 55814965
Rheumatic heart disease 13.49 10.26 5 476951 10 55815101
Anger 13.47 10.26 52 476904 11620 55803491
Crystalluria 13.44 10.26 17 476939 394 55814717
Dry mouth 13.37 10.26 428 476528 63777 55751334
Nephrolithiasis 13.36 10.26 229 476727 37106 55778005
Limb hypoplasia congenital 13.34 10.26 12 476944 185 55814926
Breast pain 13.30 10.26 30 476926 7964 55807147
Tooth abscess 13.30 10.26 65 476891 13610 55801501
International normalised ratio 13.28 10.26 9 476947 89 55815022
Dermatitis allergic 13.27 10.26 67 476889 13911 55801200
Nephritis allergic 13.27 10.26 11 476945 151 55814960
Post transplant lymphoproliferative disorder 13.26 10.26 12 476944 4660 55810451
Peripheral circulatory failure 13.25 10.26 26 476930 887 55814224
Dizziness 13.25 10.26 3481 473475 372659 55442452
Toxic encephalopathy 13.24 10.26 91 476865 5847 55809264
Stress 13.17 10.26 389 476567 58521 55756590
Abortion induced 13.15 10.26 40 476916 9605 55805506
Bone pain 13.15 10.26 324 476632 49861 55765250
Chronic left ventricular failure 13.15 10.26 16 476940 356 55814755
Hypertensive heart disease 13.13 10.26 47 476909 2316 55812795
Urinary retention 13.09 10.26 321 476635 27753 55787358
General physical health deterioration 13.09 10.26 1251 475705 168759 55646352
Cleft palate 13.05 10.26 27 476929 958 55814153
Throat tightness 13.04 10.26 124 476832 22283 55792828
Sickle cell anaemia with crisis 13.02 10.26 14 476942 5014 55810097
Neuralgia 13.00 10.26 133 476823 23562 55791549
Mucosal erosion 12.97 10.26 32 476924 1279 55813832
Second primary malignancy 12.96 10.26 27 476929 7375 55807736
Blood antidiuretic hormone increased 12.90 10.26 4 476952 3 55815108
Hypoprothrombinaemia 12.90 10.26 14 476942 274 55814837
Long QT syndrome 12.90 10.26 56 476900 3020 55812091
Congenital nail disorder 12.87 10.26 9 476947 94 55815017
Urine sodium decreased 12.86 10.26 11 476945 158 55814953
Inflammatory bowel disease 12.86 10.26 8 476948 3760 55811351
Hypersensitivity vasculitis 12.84 10.26 68 476888 3980 55811131
Pulse absent 12.84 10.26 79 476877 4888 55810223
Disturbance in attention 12.83 10.26 196 476760 32344 55782767
Amyloidosis 12.80 10.26 29 476927 1096 55814015
Drug therapeutic incompatibility 12.80 10.26 7 476949 45 55815066
Blood pH increased 12.79 10.26 19 476937 515 55814596
Haemothorax 12.75 10.26 42 476914 1984 55813127
Systolic dysfunction 12.73 10.26 35 476921 1495 55813616
Atrioventricular block second degree 12.71 10.26 64 476892 3672 55811439
Vitamin B1 decreased 12.68 10.26 7 476949 46 55815065
Catheter site rash 12.66 10.26 23 476933 740 55814371
Premature rupture of membranes 12.64 10.26 13 476943 4752 55810359
Chronic hepatic failure 12.63 10.26 19 476937 521 55814590
Dyspepsia 12.62 10.26 578 476378 82893 55732218
Physical deconditioning 12.55 10.26 20 476936 577 55814534
Face oedema 12.54 10.26 223 476733 18229 55796882
Gastrointestinal vascular malformation haemorrhagic 12.54 10.26 12 476944 201 55814910
Oesophageal spasm 12.51 10.26 52 476904 2750 55812361
Blood culture negative 12.51 10.26 10 476946 130 55814981
Asphyxia 12.49 10.26 88 476868 5701 55809410
Cyanosis central 12.42 10.26 8 476948 72 55815039
Biopsy liver 12.41 10.26 16 476940 378 55814733
Dysaesthesia 12.38 10.26 10 476946 4106 55811005
Pulmonary hypertensive crisis 12.35 10.26 12 476944 205 55814906
Intestinal ischaemia 12.35 10.26 101 476855 6854 55808257
Adrenal insufficiency 12.34 10.26 80 476876 15617 55799494
Maternal drugs affecting foetus 12.30 10.26 15 476941 5078 55810033
Portal hypertension 12.29 10.26 61 476895 3480 55811631
Endometriosis 12.28 10.26 13 476943 4689 55810422
Drug specific antibody present 12.25 10.26 8 476948 3664 55811447
Mania 12.25 10.26 53 476903 11467 55803644
Illness 12.24 10.26 212 476744 34299 55780812
Electrocardiogram abnormal 12.24 10.26 114 476842 8030 55807081
Haemorrhagic transformation stroke 12.17 10.26 29 476927 1133 55813978
Myoglobin blood increased 12.15 10.26 32 476924 1332 55813779
Brain compression 12.14 10.26 15 476941 339 55814772
Treatment noncompliance 12.07 10.26 362 476594 32261 55782850
Blood creatine phosphokinase MB increased 12.06 10.26 29 476927 1140 55813971
Diabetic foot infection 12.05 10.26 11 476945 173 55814938
Ataxia 12.05 10.26 72 476884 14331 55800780
Mouth breathing 12.02 10.26 6 476950 31 55815080
Affective disorder 12.02 10.26 18 476938 5585 55809526
Contusion 11.97 10.26 931 476025 127499 55687612
Fibrin degradation products increased 11.96 10.26 10 476946 139 55814972
Anaemia of chronic disease 11.93 10.26 39 476917 1835 55813276
Rash scarlatiniform 11.91 10.26 9 476947 107 55815004
Arteriovenous malformation 11.91 10.26 31 476925 1281 55813830
Joint laxity 11.88 10.26 3 476953 2436 55812675
Escherichia sepsis 11.83 10.26 72 476884 4437 55810674
Exostosis 11.82 10.26 76 476880 14867 55800244
Intervertebral disc protrusion 11.81 10.26 122 476834 21572 55793539
Chromaturia 11.80 10.26 189 476767 15136 55799975
Right atrial pressure increased 11.78 10.26 10 476946 142 55814969
Human herpesvirus 6 infection 11.78 10.26 4 476952 2678 55812433
Blood iron abnormal 11.76 10.26 7 476949 3370 55811741
Food allergy 11.74 10.26 37 476919 8787 55806324
Cardiac function test abnormal 11.73 10.26 8 476948 80 55815031
Hepatic steatosis 11.72 10.26 154 476802 26060 55789051
Leukocytosis 11.69 10.26 274 476682 23517 55791594
Cystitis escherichia 11.67 10.26 16 476940 402 55814709
Abdominal hernia 11.65 10.26 73 476883 4546 55810565
Glomerulonephritis 11.60 10.26 36 476920 1647 55813464
Tuberculin test positive 11.57 10.26 7 476949 3340 55811771
Mental disorder 11.55 10.26 136 476820 23468 55791643
Right ventricular systolic pressure increased 11.53 10.26 18 476938 510 55814601
Congenital oral malformation 11.51 10.26 11 476945 184 55814927
QRS axis abnormal 11.50 10.26 26 476930 981 55814130
Small intestine gangrene 11.50 10.26 4 476952 6 55815105
Base excess negative 11.50 10.26 4 476952 6 55815105
Troponin 11.50 10.26 4 476952 6 55815105
Neuroleptic malignant syndrome 11.48 10.26 54 476902 11424 55803687
Injury associated with device 11.48 10.26 7 476949 3326 55811785
Deafness bilateral 11.48 10.26 31 476925 1310 55813801
Accidental overdose 11.43 10.26 240 476716 20221 55794890
Atrial thrombosis 11.41 10.26 34 476922 1521 55813590
Pneumonia bacterial 11.38 10.26 111 476845 7917 55807194
Mitral valve disease mixed 11.34 10.26 3 476953 0 55815111
Tracheal operation 11.34 10.26 3 476953 0 55815111
Thyroid gland scan abnormal 11.34 10.26 3 476953 0 55815111
Urine chloride increased 11.34 10.26 3 476953 0 55815111
Venous pressure increased 11.34 10.26 3 476953 0 55815111
Benign small intestinal neoplasm 11.34 10.26 3 476953 0 55815111
Oedema due to renal disease 11.34 10.26 3 476953 0 55815111
Rash morbilliform 11.30 10.26 53 476903 2954 55812157
Alanine aminotransferase increased 11.28 10.26 931 476025 92731 55722380
Fracture delayed union 11.26 10.26 3 476953 2350 55812761
Urine chloride decreased 11.25 10.26 8 476948 86 55815025
Skin plaque 11.24 10.26 27 476929 7011 55808100
Generalised tonic-clonic seizure 11.23 10.26 165 476791 27401 55787710
Cardiac resynchronisation therapy 11.22 10.26 5 476951 19 55815092
Patent ductus arteriosus repair 11.22 10.26 5 476951 19 55815092
Blood pressure systolic decreased 11.20 10.26 92 476864 6251 55808860
Alanine aminotransferase abnormal 11.19 10.26 12 476944 4303 55810808
Carotid artery occlusion 11.19 10.26 48 476908 2575 55812536
Craniotomy 11.18 10.26 11 476945 191 55814920
Linear IgA disease 11.18 10.26 30 476926 1263 55813848
Angiotensin converting enzyme inhibitor foetopathy 11.17 10.26 6 476950 37 55815074
Hyperthyroidism 11.17 10.26 167 476789 13185 55801926
Respiration abnormal 11.16 10.26 84 476872 5557 55809554
Anaemia macrocytic 11.16 10.26 54 476902 3049 55812062
Cerebellar haemorrhage 11.15 10.26 30 476926 1265 55813846
Arterial fibrosis 11.13 10.26 4 476952 7 55815104
Alcohol interaction 11.11 10.26 3 476953 2330 55812781
Rash pruritic 11.09 10.26 350 476606 52244 55762867
Paranoia 11.08 10.26 50 476906 10694 55804417
Carbon dioxide abnormal 11.07 10.26 10 476946 155 55814956
Autoimmune haemolytic anaemia 11.05 10.26 68 476888 4208 55810903
Paroxysmal arrhythmia 11.04 10.26 6 476950 38 55815073
Rectal prolapse 11.04 10.26 38 476918 1836 55813275
Sensitivity to weather change 11.03 10.26 25 476931 6624 55808487
Leukaemic infiltration renal 11.02 10.26 5 476951 20 55815091
Humerus fracture 11.02 10.26 111 476845 7986 55807125
Large intestinal polypectomy 11.00 10.26 11 476945 195 55814916
Haemarthrosis 10.97 10.26 53 476903 2991 55812120
Drug dose omission by device 10.96 10.26 7 476949 3244 55811867
Cystitis klebsiella 10.95 10.26 11 476945 196 55814915
Fine motor skill dysfunction 10.95 10.26 13 476943 4452 55810659
Haemoglobinaemia 10.92 10.26 6 476950 39 55815072
Cerebral artery embolism 10.91 10.26 22 476934 766 55814345
Splenomegaly 10.91 10.26 133 476823 10035 55805076
Haemoconcentration 10.88 10.26 8 476948 91 55815020
Malnutrition 10.88 10.26 173 476783 13835 55801276
Oxygen saturation abnormal 10.87 10.26 51 476905 2843 55812268
Erythropenia 10.87 10.26 10 476946 159 55814952
Mouth haemorrhage 10.86 10.26 92 476864 6309 55808802
Infection susceptibility increased 10.83 10.26 5 476951 2778 55812333
Hypoglycaemic unconsciousness 10.82 10.26 21 476935 711 55814400
Renal tubular disorder 10.80 10.26 46 476910 2460 55812651
Mucormycosis 10.77 10.26 5 476951 2769 55812342
Acid base balance abnormal 10.70 10.26 12 476944 244 55814867
Neonatal cholestasis 10.67 10.26 6 476950 41 55815070
Varices oesophageal 10.67 10.26 51 476905 2865 55812246
Congenital diaphragmatic hernia 10.64 10.26 11 476945 203 55814908
Haemorrhoids 10.64 10.26 235 476721 19971 55795140
Aphthous ulcer 10.63 10.26 59 476897 11960 55803151
Chemical burn of oral cavity 10.60 10.26 7 476949 66 55815045
Fear of eating 10.60 10.26 14 476942 339 55814772
Anal fistula 10.59 10.26 6 476950 2968 55812143
Delirium 10.59 10.26 451 476505 42066 55773045
Diabetic metabolic decompensation 10.57 10.26 33 476923 1515 55813596
Electrocardiogram T wave peaked 10.56 10.26 11 476945 205 55814906
Long QT syndrome congenital 10.56 10.26 6 476950 42 55815069
Myxoedema coma 10.53 10.26 15 476941 391 55814720
Ventricular enlargement 10.52 10.26 7 476949 67 55815044
Incorrect dose administered by device 10.51 10.26 10 476946 3790 55811321
Pharyngeal swelling 10.48 10.26 18 476938 5288 55809823
PO2 abnormal 10.48 10.26 4 476952 9 55815102
PO2 decreased 10.47 10.26 31 476925 1382 55813729
Somatic delusion 10.47 10.26 18 476938 554 55814557
Pancreatitis acute 10.46 10.26 283 476673 24841 55790270
Hip fracture 10.44 10.26 301 476655 26672 55788439
Peripheral artery thrombosis 10.44 10.26 36 476920 1741 55813370
Transplant dysfunction 10.42 10.26 15 476941 4731 55810380
Device alarm issue 10.36 10.26 31 476925 1390 55813721
Transferrin saturation decreased 10.35 10.26 19 476937 616 55814495
Rectal ulcer haemorrhage 10.33 10.26 10 476946 170 55814941
Biliary catheter insertion 10.31 10.26 5 476951 24 55815087
Cardiorenal syndrome 10.31 10.26 22 476934 798 55814313
Ear pruritus 10.29 10.26 6 476950 2922 55812189
Fluid intake reduced 10.28 10.26 55 476901 3232 55811879

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure congestive 1990.39 11.74 3425 366149 75962 31251808
Acute kidney injury 1811.99 11.74 7234 362340 272480 31055290
Cardiac failure 1628.99 11.74 3289 366285 82664 31245106
Hyperkalaemia 966.63 11.74 2243 367331 62108 31265662
Drug ineffective 911.34 11.74 2047 367527 393526 30934244
Oedema peripheral 607.79 11.74 2714 366860 107125 31220645
Drug abuse 526.19 11.74 183 369391 87575 31240195
Off label use 514.74 11.74 2195 367379 345079 30982691
Renal failure 505.05 11.74 2798 366776 120532 31207238
Hypotension 476.42 11.74 4038 365536 200580 31127190
International normalised ratio increased 435.19 11.74 1337 368237 43886 31283884
Completed suicide 406.60 11.74 285 369289 91229 31236541
Dyspnoea 404.02 11.74 5921 363653 337558 30990212
Toxicity to various agents 372.72 11.74 994 368580 180493 31147277
Cardiac failure chronic 361.41 11.74 436 369138 6867 31320903
Blood creatinine increased 339.94 11.74 1984 367590 87094 31240676
Oedema 338.14 11.74 1179 368395 41382 31286388
Atrial fibrillation 335.03 11.74 2373 367201 111410 31216360
Fluid retention 321.09 11.74 817 368757 23985 31303785
Blood urea increased 304.83 11.74 885 368689 28127 31299643
Renal impairment 288.24 11.74 1858 367716 84491 31243279
Rheumatoid arthritis 272.45 11.74 108 369466 47701 31280069
Hypokalaemia 267.87 11.74 1286 368288 52288 31275482
Hepatic encephalopathy 233.45 11.74 502 369072 13169 31314601
Pulmonary hypertension 222.80 11.74 624 368950 19417 31308353
Chronic kidney disease 214.55 11.74 945 368629 37030 31290740
Ascites 204.61 11.74 984 368590 40029 31287741
Product use in unapproved indication 202.61 11.74 544 369030 98627 31229143
Arthralgia 192.78 11.74 1009 368565 150415 31177355
Foetal exposure during pregnancy 192.65 11.74 119 369455 40757 31287013
Treatment failure 191.91 11.74 119 369455 40673 31287097
Melaena 190.88 11.74 821 368753 31833 31295937
Suicide attempt 187.59 11.74 100 369474 37148 31290622
Hyponatraemia 187.46 11.74 1487 368087 72312 31255458
Intentional overdose 186.21 11.74 127 369447 41262 31286508
Hypervolaemia 186.17 11.74 551 369023 17700 31310070
Suicidal ideation 181.50 11.74 99 369475 36307 31291463
Headache 181.20 11.74 1325 368249 182327 31145443
Dehydration 179.65 11.74 2151 367423 116960 31210810
Anaemia 177.12 11.74 3482 366092 210040 31117730
Bradycardia 175.58 11.74 1396 368178 67931 31259839
Pleural effusion 173.84 11.74 1479 368095 73441 31254329
Ventricular tachycardia 170.66 11.74 636 368938 23065 31304705
Pulmonary oedema 164.26 11.74 983 368591 43519 31284251
Therapeutic product effect incomplete 160.88 11.74 163 369411 43533 31284237
Fall 152.99 11.74 3031 366543 183058 31144712
Myocardial infarction 152.29 11.74 2005 367569 111449 31216321
Gastrointestinal haemorrhage 151.04 11.74 1549 368025 81000 31246770
Febrile neutropenia 150.52 11.74 820 368754 121029 31206741
Syncope 150.47 11.74 1587 367987 83595 31244175
Orthostatic hypotension 148.39 11.74 616 368958 23503 31304267
Hypoglycaemia 146.45 11.74 1057 368517 49889 31277881
Injection site pain 143.23 11.74 116 369458 34518 31293252
Cardiac failure acute 141 11.74 335 369239 9406 31318364
Intentional product misuse 140.36 11.74 141 369433 37810 31289960
Neutropenia 136.74 11.74 1016 368558 139348 31188422
Intentional product use issue 133.72 11.74 231 369343 49116 31278654
Ejection fraction decreased 133.24 11.74 477 369097 16957 31310813
Right ventricular failure 132.18 11.74 296 369278 7986 31319784
Drug dependence 128.61 11.74 51 369523 22528 31305242
Lactic acidosis 127.28 11.74 720 368854 31217 31296553
N-terminal prohormone brain natriuretic peptide increased 125.80 11.74 141 369433 2043 31325727
Mitral valve incompetence 125.77 11.74 405 369169 13628 31314142
Generalised oedema 125.75 11.74 356 369218 11145 31316625
Orthopnoea 124.31 11.74 210 369364 4571 31323199
Blood potassium increased 123.44 11.74 427 369147 14918 31312852
Pyrexia 121.20 11.74 2661 366913 301179 31026591
Dyspnoea exertional 115.21 11.74 812 368762 38025 31289745
Coronary artery disease 111.72 11.74 919 368655 45168 31282602
Product dose omission issue 111.71 11.74 746 368828 104840 31222930
Hypovolaemia 111.66 11.74 279 369295 8093 31319677
Seizure 111.09 11.74 694 368880 99074 31228696
Chronic obstructive pulmonary disease 106.47 11.74 895 368679 44271 31283499
Infusion related reaction 106.27 11.74 253 369321 47802 31279968
Drug hypersensitivity 106.14 11.74 460 369114 72139 31255631
Nausea 103.28 11.74 2768 366806 305179 31022591
Rectal haemorrhage 102.45 11.74 750 368824 35554 31292216
Pulmonary arterial hypertension 99.67 11.74 296 369278 9525 31318245
Pain 99.46 11.74 1555 368019 185204 31142566
Drug interaction 98.77 11.74 3154 366420 205389 31122381
Psychotic disorder 98.14 11.74 70 369504 22223 31305547
Therapeutic product effect decreased 98.14 11.74 135 369439 31487 31296283
Musculoskeletal stiffness 97.53 11.74 210 369364 41115 31286655
Product use issue 97.50 11.74 337 369237 56422 31271348
Prostate cancer 97.38 11.74 181 369393 37420 31290350
Psoriatic arthropathy 96.31 11.74 56 369518 19827 31307943
Shock haemorrhagic 94.19 11.74 297 369277 9880 31317890
Aggression 93.51 11.74 183 369391 37108 31290662
Drug intolerance 93.44 11.74 303 369271 51730 31276040
Urticaria 91.87 11.74 352 369222 57165 31270605
Acute pulmonary oedema 90.40 11.74 232 369342 6844 31320926
Brain natriuretic peptide increased 90.16 11.74 185 369389 4691 31323079
Colitis ulcerative 90.02 11.74 52 369522 18477 31309293
Ischaemic cardiomyopathy 89.93 11.74 207 369367 5690 31322080
Tricuspid valve incompetence 89.50 11.74 266 369308 8563 31319207
Depression 89.47 11.74 655 368919 90160 31237610
Respiratory failure 87.77 11.74 1666 367908 99783 31227987
Rash 87.08 11.74 1741 367833 199745 31128025
Sinusitis 86.99 11.74 186 369388 36510 31291260
Nasopharyngitis 86.89 11.74 410 369164 62835 31264935
Hepatic failure 86.29 11.74 665 368909 32037 31295733
Congestive cardiomyopathy 86.20 11.74 226 369348 6756 31321014
COVID-19 82.80 11.74 343 369231 54478 31273292
Psoriasis 82.54 11.74 274 369300 46445 31281325
Metabolic alkalosis 82.19 11.74 89 369485 1238 31326532
Synovitis 81.92 11.74 21 369553 12262 31315508
Rales 81.69 11.74 254 369320 8385 31319385
Gravitational oedema 81.63 11.74 64 369510 569 31327201
Drug withdrawal syndrome 79.79 11.74 61 369513 18689 31309081
Gout 78.62 11.74 419 369155 17755 31310015
Schizophrenia 77.24 11.74 16 369558 10814 31316956
Cardiomegaly 76.94 11.74 353 369221 14072 31313698
Renal injury 75.76 11.74 285 369289 10380 31317390
Blood pressure decreased 75.68 11.74 876 368698 47215 31280555
Sedation 75.36 11.74 66 369508 18899 31308871
Acute myocardial infarction 75.24 11.74 915 368659 49908 31277862
Mucosal inflammation 72.39 11.74 186 369388 34241 31293529
Multiple sclerosis relapse 72.33 11.74 25 369549 12022 31315748
Hypernatraemia 72.18 11.74 225 369349 7438 31320332
Urine output decreased 72.01 11.74 259 369315 9227 31318543
Anuria 72.00 11.74 265 369309 9549 31318221
Insomnia 70.75 11.74 735 368839 94101 31233669
Appendicitis 70.21 11.74 23 369551 11442 31316328
Immune reconstitution inflammatory syndrome 70.08 11.74 7 369567 8171 31319599
Colitis 68.28 11.74 187 369387 33700 31294070
Drug ineffective for unapproved indication 68.19 11.74 64 369510 17726 31310044
Hypersensitivity 66.63 11.74 379 369195 55364 31272406
Exposure during pregnancy 64.95 11.74 11 369563 8587 31319183
Joint swelling 64.55 11.74 362 369212 53069 31274701
Fear 63.91 11.74 258 369316 9716 31318054
Accidental exposure to product 63.78 11.74 27 369547 11468 31316302
Myocardial ischaemia 63.28 11.74 371 369203 16296 31311474
Hepatic cirrhosis 62.85 11.74 354 369220 15320 31312450
Left ventricular failure 62.45 11.74 158 369416 4619 31323151
Asthenia 62.09 11.74 3209 366365 221546 31106224
Injury 61.93 11.74 418 369156 19291 31308479
Anaphylactic reaction 61.88 11.74 160 369414 29393 31298377
Venous pressure jugular increased 60.74 11.74 59 369515 716 31327054
Rhabdomyolysis 59.79 11.74 1058 368516 62523 31265247
Intentional self-injury 59.67 11.74 41 369533 13274 31314496
Arthropathy 59.45 11.74 119 369455 23932 31303838
Cardiomyopathy 59.31 11.74 343 369231 14990 31312780
Coronary artery bypass 58.90 11.74 155 369419 4644 31323126
Haematoma 58.82 11.74 482 369092 23657 31304113
Irritability 58.53 11.74 111 369463 22778 31304992
Cardiac disorder 58.47 11.74 707 368867 38507 31289263
Left ventricular dysfunction 58.34 11.74 240 369334 9117 31318653
Glomerular filtration rate decreased 57.92 11.74 283 369291 11582 31316188
Akathisia 57.71 11.74 8 369566 7245 31320525
Azotaemia 57.03 11.74 151 369423 4541 31323229
Asthma 56.90 11.74 279 369295 42332 31285438
Fatigue 56.68 11.74 3265 366309 331941 30995829
Presyncope 56.55 11.74 371 369203 16957 31310813
Vomiting 56.28 11.74 2090 367484 221883 31105887
Overdose 56.09 11.74 674 368900 83990 31243780
Infection 55.52 11.74 649 368925 81282 31246488
Injection site erythema 55.47 11.74 52 369522 14410 31313360
Injection site reaction 54.76 11.74 34 369540 11617 31316153
Inappropriate schedule of product administration 54.74 11.74 357 369217 50466 31277304
Malignant neoplasm progression 54.21 11.74 624 368950 78374 31249396
Haematotoxicity 54.20 11.74 9 369565 7128 31320642
Neuropathy peripheral 54.10 11.74 592 368982 75057 31252713
Jugular vein distension 54.01 11.74 51 369523 596 31327174
Drug resistance 53.02 11.74 122 369452 23331 31304439
Cardiogenic shock 52.76 11.74 444 369130 21964 31305806
Pathogen resistance 52.33 11.74 18 369556 8683 31319087
Vitamin B1 deficiency 52.04 11.74 37 369537 279 31327491
Atrioventricular block 51.56 11.74 195 369379 7120 31320650
Cardiac arrest 51.31 11.74 1381 368193 87681 31240089
Haemoglobin decreased 50.83 11.74 1695 367879 110980 31216790
Loss of personal independence in daily activities 50.58 11.74 165 369409 28123 31299647
Cytomegalovirus infection 50.03 11.74 136 369438 24571 31303199
Pemphigoid 49.88 11.74 210 369364 8061 31319709
Cardioactive drug level increased 49.72 11.74 78 369496 1592 31326178
Peripheral swelling 49.55 11.74 1087 368487 66778 31260992
Aortic stenosis 49.39 11.74 129 369445 3847 31323923
Poisoning 49.29 11.74 30 369544 10361 31317409
Uveitis 48.75 11.74 10 369564 6806 31320964
Diastolic dysfunction 48.73 11.74 155 369419 5180 31322590
Arrhythmia 48.71 11.74 595 368979 32482 31295288
Substance abuse 48.19 11.74 12 369562 7146 31320624
Serotonin syndrome 48.04 11.74 91 369483 18682 31309088
Migraine 47.65 11.74 57 369517 14123 31313647
Infective pulmonary exacerbation of cystic fibrosis 47.45 11.74 9 369565 6475 31321295
Anhedonia 47.28 11.74 192 369382 7250 31320520
Sopor 47.04 11.74 262 369312 11290 31316480
Torsade de pointes 46.96 11.74 181 369393 6669 31321101
Dyspnoea paroxysmal nocturnal 46.62 11.74 70 369504 1373 31326397
Oliguria 46.59 11.74 196 369378 7521 31320249
Back pain 46.09 11.74 949 368625 108464 31219306
Ankylosing spondylitis 45.60 11.74 7 369567 5874 31321896
Stomatitis 45.59 11.74 271 369303 39167 31288603
Diabetic ketoacidosis 44.99 11.74 80 369494 16825 31310945
Concomitant disease progression 44.59 11.74 91 369483 2298 31325472
Hypoglycaemic coma 44.33 11.74 87 369487 2134 31325636
Abnormal behaviour 43.99 11.74 137 369437 23691 31304079
Device interaction 43.94 11.74 43 369531 527 31327243
Hypoaesthesia 43.90 11.74 429 369145 55593 31272177
Bundle branch block left 43.89 11.74 153 369421 5365 31322405
Haematuria 43.64 11.74 771 368803 45543 31282227
Agitation 43.64 11.74 412 369162 53757 31274013
Erectile dysfunction 43.52 11.74 100 369474 19135 31308635
Nephrolithiasis 43.19 11.74 168 369406 27171 31300599
Neutrophil count decreased 43.11 11.74 340 369234 46054 31281716
Therapeutic response shortened 42.93 11.74 8 369566 5829 31321941
Left ventricular dilatation 42.46 11.74 47 369527 671 31327099
Eosinophilia 42.29 11.74 436 369138 22817 31304953
Generalised tonic-clonic seizure 41.65 11.74 108 369466 19823 31307947
Hallucination, auditory 41.22 11.74 36 369538 10324 31317446
Blood pressure fluctuation 41.07 11.74 132 369442 22604 31305166
Respiratory depression 41.07 11.74 66 369508 14444 31313326
Lymphadenopathy 40.96 11.74 161 369413 25960 31301810
Concomitant disease aggravated 40.82 11.74 144 369430 5080 31322690
Iron deficiency anaemia 40.63 11.74 216 369358 9143 31318627
Chills 40.52 11.74 614 368960 73536 31254234
Polyuria 40.43 11.74 189 369385 7594 31320176
Blood creatine increased 40.39 11.74 132 369442 4476 31323294
Product storage error 40.17 11.74 16 369558 7050 31320720
Atrial flutter 39.76 11.74 300 369274 14355 31313415
Syringe issue 39.49 11.74 5 369569 4851 31322919
Oesophageal varices haemorrhage 38.86 11.74 96 369478 2764 31325006
Paraesthesia 38.42 11.74 443 369131 55628 31272142
Multiple sclerosis 38.41 11.74 23 369551 8014 31319756
Device issue 38.19 11.74 26 369548 8458 31319312
Gastrointestinal disorder 37.96 11.74 206 369368 30454 31297316
Blood potassium decreased 37.89 11.74 324 369250 16102 31311668
Hepatorenal syndrome 37.45 11.74 86 369488 2360 31325410
Acute respiratory failure 37.21 11.74 495 369079 27560 31300210
Neoplasm progression 37.11 11.74 117 369457 20155 31307615
Therapy partial responder 37.07 11.74 15 369559 6547 31321223
Low cardiac output syndrome 36.83 11.74 39 369535 528 31327242
Abdominal pain 36.80 11.74 1361 368213 144591 31183179
Vascular purpura 36.66 11.74 63 369511 1391 31326379
Memory impairment 36.56 11.74 277 369297 37853 31289917
Dialysis 36.43 11.74 230 369344 10373 31317397
Neuroleptic malignant syndrome 36.34 11.74 90 369484 16779 31310991
Upper gastrointestinal haemorrhage 35.88 11.74 421 369153 22762 31305008
Hypocalcaemia 35.75 11.74 403 369171 21575 31306195
Epistaxis 35.70 11.74 849 368725 52858 31274912
Euphoric mood 35.64 11.74 7 369567 4913 31322857
Arthritis 35.58 11.74 181 369393 27204 31300566
Injection site swelling 35.57 11.74 39 369535 10048 31317722
Hypoxia 35.49 11.74 802 368772 49511 31278259
Erythema 35.46 11.74 692 368882 79713 31248057
Anxiety 35.31 11.74 800 368774 90233 31237537
Anger 35.22 11.74 47 369527 11106 31316664
International normalised ratio decreased 35.05 11.74 121 369453 4222 31323548
Cardiorenal syndrome 34.97 11.74 42 369532 658 31327112
Blood pressure increased 34.93 11.74 686 368888 78947 31248823
Acute graft versus host disease 34.87 11.74 14 369560 6139 31321631
Tremor 34.84 11.74 654 368920 75766 31252004
C-reactive protein abnormal 34.71 11.74 24 369550 7745 31320025
Acrodermatitis enteropathica 34.63 11.74 10 369564 0 31327770
Diverticulitis 34.56 11.74 107 369467 18538 31309232
Vision blurred 34.53 11.74 317 369257 41598 31286172
Transfusion 34.31 11.74 178 369396 7462 31320308
No adverse event 34.03 11.74 116 369458 19509 31308261
Haemodialysis 33.96 11.74 217 369357 9828 31317942
Hyperuricaemia 33.90 11.74 174 369400 7264 31320506
Hepatotoxicity 33.89 11.74 112 369462 19014 31308756
Mental disorder 33.72 11.74 69 369505 13765 31314005
White blood cell count decreased 33.63 11.74 769 368805 86629 31241141
Withdrawal syndrome 33.44 11.74 53 369521 11664 31316106
Prothrombin time prolonged 33.41 11.74 201 369373 8911 31318859
Multiple-drug resistance 33.25 11.74 6 369568 4474 31323296
Subdural haematoma 33.22 11.74 353 369221 18618 31309152
Therapeutic response decreased 32.88 11.74 178 369396 26331 31301439
Cardiac output decreased 32.84 11.74 45 369529 809 31326961
Nightmare 32.69 11.74 57 369517 12080 31315690
Post transplant lymphoproliferative disorder 32.56 11.74 15 369559 6061 31321709
Injection site haemorrhage 32.17 11.74 35 369539 9050 31318720
Paranoia 31.81 11.74 46 369528 10509 31317261
Depressed mood 31.77 11.74 102 369472 17473 31310297
Sexual dysfunction 31.57 11.74 15 369559 5953 31321817
Night sweats 31.55 11.74 87 369487 15645 31312125
Cardiac murmur 31.38 11.74 159 369415 6603 31321167
Aortic valve incompetence 31.35 11.74 138 369436 5403 31322367
Cor pulmonale 31.16 11.74 40 369534 673 31327097
Extrapyramidal disorder 31.10 11.74 56 369518 11722 31316048
Cardiac amyloidosis 31.05 11.74 48 369526 967 31326803
Diplopia 30.94 11.74 75 369499 14087 31313683
Polyomavirus-associated nephropathy 30.71 11.74 3 369571 3565 31324205
Premature baby 30.51 11.74 108 369466 17958 31309812
Tenosynovitis 30.48 11.74 6 369568 4204 31323566
Sleep disorder 30.47 11.74 181 369393 26167 31301603
Hypocoagulable state 30.44 11.74 45 369529 870 31326900
Sudden cardiac death 30.41 11.74 99 369475 3350 31324420
Left ventricular hypertrophy 30.32 11.74 167 369407 7165 31320605
Blood lactic acid 30.28 11.74 28 369546 318 31327452
Ventricular extrasystoles 30.17 11.74 228 369346 10914 31316856
Somnolence 30.07 11.74 906 368668 98539 31229231
Anal abscess 30.04 11.74 15 369559 5785 31321985
Progressive multifocal leukoencephalopathy 29.94 11.74 38 369536 9175 31318595
Dyspnoea at rest 29.92 11.74 100 369474 3431 31324339
Congestive hepatopathy 29.84 11.74 64 369510 1675 31326095
Diffuse large B-cell lymphoma 29.82 11.74 34 369540 8607 31319163
Muscle spasms 29.81 11.74 589 368985 67729 31260041
Hypercreatinaemia 29.78 11.74 21 369553 156 31327614
Peritonitis bacterial 29.58 11.74 141 369433 5711 31322059
Herpes zoster 29.47 11.74 235 369339 31758 31296012
Mucormycosis 29.46 11.74 14 369560 5556 31322214
Suspected suicide 29.43 11.74 6 369568 4101 31323669
Dystonia 29.42 11.74 46 369528 10179 31317591
Disturbance in attention 29.38 11.74 148 369426 22302 31305468
Pancreatitis 29.26 11.74 271 369303 35500 31292270
Acute graft versus host disease in skin 29.05 11.74 10 369564 4822 31322948
Troponin increased 28.99 11.74 208 369366 9794 31317976
Pneumonia 28.81 11.74 4391 365183 330921 30996849
Multiple organ dysfunction syndrome 28.71 11.74 1018 368556 67185 31260585
Haematemesis 28.58 11.74 439 369135 25214 31302556
Dilatation atrial 28.58 11.74 66 369508 1818 31325952
Normochromic normocytic anaemia 28.55 11.74 104 369470 3728 31324042
Scrotal oedema 28.47 11.74 60 369514 1551 31326219
Atrioventricular block complete 28.32 11.74 184 369390 8381 31319389
Bradyarrhythmia 28.21 11.74 70 369504 2021 31325749
Panic attack 28.17 11.74 36 369538 8667 31319103
Blood loss anaemia 28.13 11.74 170 369404 7549 31320221
Frequent bowel movements 28.01 11.74 47 369527 10112 31317658
Emotional distress 27.95 11.74 273 369301 14083 31313687
Alopecia 27.91 11.74 135 369439 20560 31307210
Toxic epidermal necrolysis 27.79 11.74 349 369225 19175 31308595
Influenza like illness 27.73 11.74 178 369396 25259 31302511
Mania 27.65 11.74 40 369534 9137 31318633
Lipodystrophy acquired 27.44 11.74 3 369571 3261 31324509
Neurotoxicity 27.40 11.74 97 369477 16129 31311641
Hyperhidrosis 27.34 11.74 588 368986 66805 31260965
Basal cell carcinoma 27.27 11.74 114 369460 18065 31309705
Tinnitus 27.01 11.74 98 369476 16177 31311593
Aspergillus infection 26.84 11.74 59 369515 11469 31316301
Nephrotic syndrome 26.65 11.74 156 369418 6847 31320923
Hyperparathyroidism secondary 26.64 11.74 56 369518 1445 31326325
Tardive dyskinesia 26.44 11.74 16 369558 5543 31322227
Graft versus host disease 26.41 11.74 51 369523 10396 31317374
Left ventricular enlargement 26.40 11.74 36 369538 644 31327126
Pulmonary congestion 26.31 11.74 249 369325 12734 31315036
Chronic hepatic failure 26.28 11.74 30 369544 444 31327326
Abdominal discomfort 26.14 11.74 433 369141 51134 31276636
Metabolic acidosis 26.10 11.74 625 368949 38952 31288818
Prerenal failure 26.03 11.74 63 369511 1790 31325980
Hepatic cancer 25.69 11.74 167 369407 7608 31320162
Dyskinesia 25.60 11.74 141 369433 20769 31307001
Hepatitis B reactivation 25.50 11.74 5 369569 3513 31324257
Priapism 25.39 11.74 11 369563 4609 31323161
Dysmorphism 25.38 11.74 3 369571 3069 31324701
Dizziness 25.32 11.74 2672 366902 196475 31131295
Atrioventricular block first degree 25.31 11.74 133 369441 5604 31322166
Poisoning deliberate 25.23 11.74 29 369545 7315 31320455
Cardiac valve disease 25.22 11.74 84 369490 2877 31324893
Pericardial haemorrhage 25.17 11.74 85 369489 2932 31324838
Neutropenic sepsis 25.16 11.74 68 369506 12311 31315459
Pericardial effusion 25.08 11.74 384 369190 22039 31305731
Activated partial thromboplastin time prolonged 24.98 11.74 173 369401 8052 31319718
Amnesia 24.88 11.74 165 369409 23237 31304533
Injection site bruising 24.78 11.74 34 369540 7941 31319829
Ventricular failure 24.76 11.74 16 369558 101 31327669
Flushing 24.75 11.74 228 369346 29900 31297870
Haemophagocytic lymphohistiocytosis 24.61 11.74 63 369511 11615 31316155
Tachycardia 24.61 11.74 688 368886 75519 31252251
Mood altered 24.54 11.74 37 369537 8309 31319461
Tuberculosis 24.50 11.74 37 369537 8304 31319466
Salivary hypersecretion 24.44 11.74 33 369541 7759 31320011
Blood pressure systolic decreased 24.39 11.74 104 369470 4015 31323755
Hydrothorax 24.26 11.74 29 369545 452 31327318
Alanine aminotransferase abnormal 24.22 11.74 8 369566 3959 31323811
Mitral valve thickening 24.21 11.74 26 369548 358 31327412
Epilepsy 24.09 11.74 145 369429 20896 31306874
Nephrogenic anaemia 23.87 11.74 66 369508 2037 31325733
Pseudoporphyria 23.84 11.74 24 369550 305 31327465
Haemoconcentration 23.72 11.74 11 369563 31 31327739
Unevaluable event 23.67 11.74 494 369080 30081 31297689
Ear infection 23.65 11.74 42 369532 8839 31318931
Haemoptysis 23.61 11.74 516 369058 31673 31296097
Bladder cancer 23.57 11.74 90 369484 14635 31313135
Musculoskeletal pain 23.53 11.74 228 369346 29600 31298170
Oropharyngeal pain 23.45 11.74 244 369330 31239 31296531
Bone pain 23.41 11.74 131 369443 19220 31308550
Myelosuppression 23.36 11.74 92 369482 14828 31312942
Epstein-Barr virus infection 23.31 11.74 28 369546 6925 31320845
Pruritus 23.29 11.74 1207 368367 123960 31203810
Hypomagnesaemia 23.13 11.74 331 369243 18727 31309043
Cognitive disorder 22.98 11.74 183 369391 24740 31303030
Angina pectoris 22.98 11.74 479 369095 29162 31298608
Atrial tachycardia 22.80 11.74 63 369511 1944 31325826
Ejection fraction abnormal 22.79 11.74 39 369535 858 31326912
Incorrect dose administered 22.75 11.74 287 369287 35465 31292305
Maternal exposure during pregnancy 22.71 11.74 13 369561 4643 31323127
Bronchopulmonary aspergillosis 22.69 11.74 82 369492 13552 31314218
Candida infection 22.54 11.74 105 369469 16153 31311617
Influenza 22.53 11.74 372 369202 43953 31283817
Apparent death 22.49 11.74 7 369567 3598 31324172
Emotional disorder 22.43 11.74 17 369557 5232 31322538
Anal fistula 22.42 11.74 14 369560 4769 31323001
Crohn's disease 22.35 11.74 10 369564 4111 31323659
Adverse drug reaction 22.34 11.74 187 369387 25014 31302756
Enteritis 22.33 11.74 30 369544 7069 31320701
Osteonecrosis of jaw 22.08 11.74 113 369461 16958 31310812
Status epilepticus 22.06 11.74 70 369504 12036 31315734
Hypersensitivity vasculitis 22.01 11.74 86 369488 3189 31324581
Intraocular pressure increased 21.91 11.74 17 369557 5170 31322600
Pneumocystis jirovecii pneumonia 21.84 11.74 124 369450 18127 31309643
Chronic graft versus host disease 21.80 11.74 12 369562 4380 31323390
Dermatitis atopic 21.75 11.74 15 369559 4847 31322923
Eyelid ptosis 21.65 11.74 19 369555 5436 31322334
Incorrect route of product administration 21.62 11.74 67 369507 11606 31316164
Renal ischaemia 21.55 11.74 29 369545 512 31327258
Impaired work ability 21.53 11.74 22 369552 5855 31321915
Neuromyopathy 21.52 11.74 40 369534 941 31326829
Hyponatraemic syndrome 21.52 11.74 18 369556 177 31327593
Varices oesophageal 21.51 11.74 87 369487 3279 31324491
Tendonitis 21.44 11.74 42 369532 8516 31319254
Injection site mass 21.43 11.74 22 369552 5842 31321928
Myalgia 21.38 11.74 712 368862 76546 31251224
Catatonia 21.34 11.74 15 369559 4799 31322971
Small for dates baby 21.24 11.74 8 369566 3647 31324123
Feeling abnormal 21.23 11.74 504 369070 56498 31271272
Dilatation ventricular 21.21 11.74 71 369503 2438 31325332
Mental impairment 21.21 11.74 50 369524 9482 31318288
Arteriospasm coronary 21.18 11.74 4 369570 2887 31324883
Blood pressure diastolic abnormal 21.05 11.74 10 369564 3969 31323801
Hypercapnia 21.04 11.74 97 369477 3874 31323896
Angina unstable 20.87 11.74 211 369363 10984 31316786
Mood swings 20.79 11.74 34 369540 7390 31320380
Cellulitis 20.77 11.74 719 368855 47299 31280471
Muscle haemorrhage 20.71 11.74 88 369486 3392 31324378
Graft versus host disease in skin 20.69 11.74 8 369566 3589 31324181
Coma hepatic 20.68 11.74 26 369548 428 31327342
Ventricular dysfunction 20.63 11.74 90 369484 3510 31324260
Exercise tolerance decreased 20.56 11.74 108 369466 4550 31323220
Cytokine release syndrome 20.50 11.74 112 369462 16530 31311240
International normalised ratio abnormal 20.48 11.74 81 369493 3021 31324749
Eye pain 20.48 11.74 74 369500 12230 31315540
Maternal drugs affecting foetus 20.36 11.74 10 369564 3893 31323877
Purpura 20.32 11.74 186 369388 9424 31318346
Posthaemorrhagic hydrocephalus 20.18 11.74 14 369560 101 31327669
Microcytic anaemia 20.18 11.74 62 369512 2033 31325737
Posterior reversible encephalopathy syndrome 20.16 11.74 50 369524 9317 31318453
Muscle twitching 20.10 11.74 41 369533 8189 31319581
Occult blood positive 20.05 11.74 93 369481 3724 31324046
Viral mutation identified 19.93 11.74 4 369570 2765 31325005
Dermatitis exfoliative generalised 19.90 11.74 82 369492 3117 31324653
Drug screen positive 19.89 11.74 10 369564 3842 31323928
Second primary malignancy 19.89 11.74 32 369542 7000 31320770
Ammonia increased 19.83 11.74 98 369476 4029 31323741
Drug level decreased 19.82 11.74 31 369543 6859 31320911
Inflammatory bowel disease 19.78 11.74 3 369571 2540 31325230
Left atrial enlargement 19.77 11.74 34 369540 751 31327019
Crepitations 19.77 11.74 77 369497 2851 31324919
Hepatitis B 19.68 11.74 23 369551 5758 31322012
Arteriosclerosis 19.63 11.74 202 369372 10565 31317205
Electrocardiogram QT prolonged 19.61 11.74 581 368993 37406 31290364
Graft versus host disease in gastrointestinal tract 19.58 11.74 8 369566 3471 31324299
Hypercreatininaemia 19.57 11.74 26 369548 453 31327317
Anticoagulation drug level increased 19.55 11.74 27 369547 489 31327281
Unintentional medical device removal 19.54 11.74 3 369571 2517 31325253
Vascular graft 19.46 11.74 49 369525 1428 31326342
Gastrointestinal vascular malformation haemorrhagic 19.42 11.74 29 369545 566 31327204
Blood creatinine abnormal 19.36 11.74 63 369511 2131 31325639
Renal artery stenosis 19.35 11.74 62 369512 2080 31325690
Knee arthroplasty 19.35 11.74 29 369545 6529 31321241
Dermatitis bullous 19.35 11.74 132 369442 6113 31321657
Long QT syndrome 19.33 11.74 66 369508 2290 31325480
Systemic infection 19.30 11.74 8 369566 3441 31324329
Creatinine renal clearance decreased 19.25 11.74 81 369493 3108 31324662
Alcohol abuse 19.22 11.74 15 369559 4549 31323221
Visual impairment 19.20 11.74 253 369321 31026 31296744
Pulmonary tuberculosis 19.20 11.74 16 369558 4695 31323075
Drug reaction with eosinophilia and systemic symptoms 19.17 11.74 472 369102 29546 31298224
Ischaemic stroke 19.12 11.74 291 369283 16680 31311090
Cytomegalovirus infection reactivation 19.12 11.74 11 369563 3918 31323852
Left ventricle outflow tract obstruction 19.07 11.74 15 369559 134 31327636
Neck pain 18.98 11.74 173 369401 22737 31305033
Superinfection 18.96 11.74 63 369511 2155 31325615
Abscess 18.86 11.74 61 369513 10426 31317344
Central nervous system lesion 18.85 11.74 25 369549 5923 31321847
Weight decreased 18.82 11.74 1607 367967 158345 31169425
Leukopenia 18.68 11.74 522 369052 57306 31270464
Ventricular internal diameter abnormal 18.45 11.74 14 369560 118 31327652
Photophobia 18.42 11.74 29 369545 6400 31321370
Alcohol poisoning 18.32 11.74 7 369567 3164 31324606
Meningitis aseptic 18.29 11.74 6 369568 2982 31324788
Dysphagia 18.28 11.74 522 369052 57154 31270616
Acute lymphocytic leukaemia 18.26 11.74 9 369565 3497 31324273
Ventricular hypokinesia 18.25 11.74 107 369467 4699 31323071
Atrial septal defect 18.23 11.74 33 369541 6894 31320876
Nephrocalcinosis 18.18 11.74 28 369546 562 31327208
Exposure to toxic agent 18.16 11.74 4 369570 2591 31325179
Alcohol interaction 18.16 11.74 5 369569 2784 31324986
Renal cancer 18.13 11.74 39 369535 7640 31320130
Peripheral venous disease 18.05 11.74 66 369508 2370 31325400
Hepatic enzyme increased 18.04 11.74 302 369272 35606 31292164
Hypogammaglobulinaemia 17.96 11.74 31 369543 6596 31321174
Cataract 17.94 11.74 184 369390 23623 31304147
Device leakage 17.93 11.74 22 369552 5391 31322379
Peripheral vascular disorder 17.91 11.74 105 369469 4611 31323159
Wrong technique in product usage process 17.89 11.74 277 369297 33066 31294704
Strongyloidiasis 17.87 11.74 4 369570 2562 31325208
Apathy 17.86 11.74 30 369544 6452 31321318
Respiratory distress 17.82 11.74 515 369059 33038 31294732
Faeces discoloured 17.76 11.74 242 369332 13544 31314226
Asterixis 17.71 11.74 41 369533 1131 31326639
Diabetic foot 17.69 11.74 65 369509 2340 31325430
Pulmonary arterial pressure increased 17.65 11.74 42 369532 1180 31326590
BK virus infection 17.63 11.74 20 369554 5075 31322695
Cardio-respiratory distress 17.63 11.74 14 369560 127 31327643
Delusion 17.52 11.74 76 369498 11921 31315849
Urinary tract discomfort 17.48 11.74 13 369561 106 31327664
Ventricular dyssynchrony 17.39 11.74 7 369567 12 31327758
Ventricular arrhythmia 17.37 11.74 107 369467 4784 31322986
Spontaneous haematoma 17.34 11.74 25 369549 472 31327298
Cardiospasm 17.32 11.74 5 369569 0 31327770
Thirst decreased 17.32 11.74 5 369569 0 31327770
Lower gastrointestinal haemorrhage 17.29 11.74 166 369408 8523 31319247
Drug level below therapeutic 17.27 11.74 20 369554 5028 31322742
Crying 17.25 11.74 24 369550 5573 31322197
Road traffic accident 17.16 11.74 116 369458 16265 31311505
Hand deformity 17.16 11.74 7 369567 3040 31324730
Drug specific antibody present 17.10 11.74 6 369568 2859 31324911
Upper motor neurone lesion 17.09 11.74 13 369561 110 31327660
Aortic valve stenosis 17.07 11.74 65 369509 2381 31325389
Medication error 17.00 11.74 366 369208 22406 31305364
Hypoalbuminaemia 16.94 11.74 200 369374 10828 31316942
Throat irritation 16.87 11.74 54 369520 9260 31318510
Drug-induced liver injury 16.87 11.74 192 369382 24171 31303599
Narrow anterior chamber angle 16.81 11.74 13 369561 113 31327657
Squamous cell carcinoma 16.80 11.74 66 369508 10645 31317125
Post procedural haematoma 16.77 11.74 46 369528 1413 31326357
Gastritis erosive 16.77 11.74 118 369456 5521 31322249
Gastric varices 16.76 11.74 23 369551 414 31327356
Disease recurrence 16.75 11.74 138 369436 18523 31309247
Virologic failure 16.67 11.74 8 369566 3157 31324613
Blood sodium decreased 16.64 11.74 261 369313 15054 31312716
Aspiration pleural cavity 16.50 11.74 32 369542 778 31326992
Blood uric acid increased 16.50 11.74 129 369445 6241 31321529
Blood bilirubin increased 16.44 11.74 531 369043 34605 31293165
Product quality issue 16.42 11.74 115 369459 15996 31311774
Dependence on oxygen therapy 16.35 11.74 16 369558 196 31327574
Atrial thrombosis 16.33 11.74 57 369517 2000 31325770
Device use error 16.32 11.74 3 369571 2207 31325563
Paracentesis 16.28 11.74 22 369552 390 31327380
Gastrointestinal angiodysplasia 16.26 11.74 27 369547 579 31327191
Speech disorder 16.26 11.74 192 369382 24009 31303761
Respiratory arrest 16.25 11.74 212 369362 26045 31301725
Diverticulum intestinal 16.22 11.74 84 369490 3519 31324251
Hypochromasia 16.20 11.74 19 369555 290 31327480
Right ventricular dysfunction 16.13 11.74 36 369538 969 31326801
Cytomegalovirus chorioretinitis 16.12 11.74 10 369564 3418 31324352
Subarachnoid haemorrhage 16.10 11.74 187 369387 10084 31317686
Abdominal cavity drainage 16.10 11.74 20 369554 325 31327445
Renal artery thrombosis 16.05 11.74 19 369555 293 31327477
Diabetic nephropathy 16.04 11.74 56 369518 1965 31325805
Drug abuser 16.03 11.74 13 369561 3867 31323903
Increased appetite 16.01 11.74 31 369543 6313 31321457
Dermatitis exfoliative 16.01 11.74 130 369444 6362 31321408
Bipolar disorder 15.99 11.74 12 369562 3712 31324058
Tongue disorder 15.98 11.74 21 369553 4996 31322774
Base excess decreased 15.98 11.74 16 369558 202 31327568
Sudden death 15.95 11.74 247 369327 14210 31313560
Gouty tophus 15.94 11.74 13 369561 123 31327647
Hypoperfusion 15.92 11.74 38 369536 1070 31326700
Malignant melanoma 15.92 11.74 42 369532 7665 31320105
Ecchymosis 15.82 11.74 129 369445 6321 31321449
Acquired macroglossia 15.82 11.74 7 369567 17 31327753
Base excess increased 15.79 11.74 8 369566 29 31327741
International normalised ratio fluctuation 15.77 11.74 37 369537 1030 31326740
Mitral valve calcification 15.70 11.74 25 369549 517 31327253
Delayed graft function 15.65 11.74 58 369516 2097 31325673
Bone marrow failure 15.60 11.74 231 369343 27777 31299993
Viral infection 15.56 11.74 112 369462 15481 31312289
Feeling hot 15.52 11.74 118 369456 16115 31311655
Product substitution issue 15.52 11.74 57 369517 9375 31318395
Brain natriuretic peptide abnormal 15.52 11.74 19 369555 304 31327466
Encephalopathy 15.51 11.74 492 369082 31982 31295788
Disinhibition 15.47 11.74 6 369568 2687 31325083
Obsessive-compulsive disorder 15.39 11.74 21 369553 4916 31322854
Urine calcium decreased 15.39 11.74 6 369568 9 31327761
Sinus node dysfunction 15.35 11.74 87 369487 3773 31323997
Illness 15.30 11.74 56 369518 9221 31318549
Social avoidant behaviour 15.29 11.74 8 369566 3005 31324765
Fistula 15.29 11.74 27 369547 5694 31322076
Transaminases increased 15.26 11.74 196 369378 24145 31303625
Head injury 15.22 11.74 276 369298 16382 31311388
Grip strength decreased 15.03 11.74 6 369568 2640 31325130
Cardioactive drug level decreased 15.00 11.74 10 369564 67 31327703
Adult failure to thrive 15.00 11.74 5 369569 3 31327767
Lymphoma 14.98 11.74 71 369503 10872 31316898
Neonatal respiratory distress syndrome 14.86 11.74 14 369560 3871 31323899
Heart sounds abnormal 14.85 11.74 31 369543 796 31326974
Pulmonary arterial wedge pressure increased 14.76 11.74 11 369563 90 31327680
Skin toxicity 14.75 11.74 16 369558 4143 31323627
Right atrial enlargement 14.75 11.74 16 369558 223 31327547
Intraductal papillary mucinous neoplasm 14.74 11.74 24 369550 506 31327264
Ventricular fibrillation 14.74 11.74 305 369269 18543 31309227
Mitral valve replacement 14.73 11.74 14 369560 165 31327605
Coronary arterial stent insertion 14.65 11.74 89 369485 3959 31323811
Mycobacterial infection 14.64 11.74 4 369570 2239 31325531
Gouty arthritis 14.63 11.74 35 369539 987 31326783
Gastrointestinal tract mucosal pigmentation 14.55 11.74 21 369553 397 31327373
Uraemic encephalopathy 14.51 11.74 17 369557 259 31327511
C-reactive protein increased 14.50 11.74 444 369130 48206 31279564
Abnormal dreams 14.48 11.74 39 369535 7069 31320701
Tongue oedema 14.43 11.74 66 369508 2627 31325143
Accidental death 14.39 11.74 4 369570 2213 31325557
Middle insomnia 14.38 11.74 31 369543 6068 31321702
Attention deficit hyperactivity disorder 14.35 11.74 5 369569 2393 31325377
Loss of libido 14.33 11.74 5 369569 2390 31325380
Ventricular flutter 14.32 11.74 10 369564 73 31327697
Pulmonary vein stenosis 14.32 11.74 8 369566 37 31327733
Ventricular dyskinesia 14.32 11.74 16 369558 231 31327539
Upper respiratory tract infection 14.28 11.74 249 369325 29173 31298597
Impaired quality of life 14.25 11.74 12 369562 3504 31324266
Oropharyngeal discomfort 14.24 11.74 7 369567 2724 31325046
Dry mouth 14.23 11.74 200 369374 24258 31303512
Osteonecrosis 14.20 11.74 99 369475 13785 31313985
Partial seizures 14.19 11.74 18 369556 4348 31323422
Injection site pruritus 14.17 11.74 32 369542 6162 31321608
Toxic skin eruption 14.07 11.74 181 369393 9999 31317771
Ischaemic hepatitis 14.05 11.74 46 369528 1561 31326209
Adenovirus infection 14.05 11.74 21 369553 4733 31323037
Coagulation time prolonged 14.00 11.74 39 369535 1209 31326561
Coagulopathy 13.96 11.74 298 369276 18217 31309553
Psychiatric decompensation 13.92 11.74 3 369571 1973 31325797
Gastric ulcer 13.91 11.74 244 369330 14390 31313380
Mumps 13.90 11.74 10 369564 77 31327693
Cerebral haemorrhage 13.86 11.74 490 369084 32322 31295448
Liver function test increased 13.84 11.74 89 369485 12625 31315145
Antipsychotic drug level increased 13.78 11.74 12 369562 3446 31324324
Melanoderma 13.76 11.74 13 369561 152 31327618
Polyneuropathy 13.75 11.74 92 369482 12930 31314840
Haematocrit decreased 13.72 11.74 453 369121 29608 31298162
Phlebitis deep 13.72 11.74 6 369568 14 31327756
Amyloidosis 13.66 11.74 57 369517 2179 31325591
Restlessness 13.60 11.74 191 369383 23170 31304600
Hypertriglyceridaemia 13.58 11.74 46 369528 7752 31320018
Prostate cancer stage II 13.56 11.74 4 369570 2129 31325641
Abdominal wall haemorrhage 13.55 11.74 21 369553 424 31327346
Ejection fraction 13.50 11.74 10 369564 81 31327689
Heparin-induced thrombocytopenia 13.49 11.74 107 369467 5199 31322571
Blood cholesterol increased 13.38 11.74 129 369445 16764 31311006
Depressive symptom 13.38 11.74 4 369570 2110 31325660
Gastritis haemorrhagic 13.35 11.74 41 369533 1344 31326426
Tooth infection 13.27 11.74 32 369542 6022 31321748
Sinus arrhythmia 13.25 11.74 29 369545 770 31327000
Visual field defect 13.16 11.74 18 369556 4210 31323560
Lymphoproliferative disorder 13.10 11.74 7 369567 2598 31325172
Nephrogenic systemic fibrosis 13.10 11.74 85 369489 3870 31323900
Blindness 13.08 11.74 89 369485 12462 31315308
Intervertebral disc protrusion 13.08 11.74 58 369516 9042 31318728
Hypertensive cardiomyopathy 13.07 11.74 12 369562 135 31327635
Cerebrovascular accident 13.00 11.74 1086 368488 78398 31249372
Muscle spasticity 12.99 11.74 29 369545 5606 31322164
Alveolar lung disease 12.98 11.74 19 369555 364 31327406
Lividity 12.93 11.74 12 369562 137 31327633
Pericardial drainage 12.93 11.74 10 369564 87 31327683
Oxygen consumption decreased 12.91 11.74 14 369560 195 31327575
Rash maculo-papular 12.90 11.74 392 369182 25327 31302443
Acquired haemophilia 12.79 11.74 32 369542 929 31326841
Electrocardiogram T wave peaked 12.76 11.74 23 369551 528 31327242
Peripheral arterial occlusive disease 12.72 11.74 106 369468 5227 31322543
Alkalosis 12.69 11.74 11 369563 114 31327656
Right ventricular systolic pressure decreased 12.67 11.74 6 369568 18 31327752
Hepatocellular carcinoma 12.67 11.74 157 369417 8599 31319171
Visual acuity reduced 12.65 11.74 116 369458 15227 31312543
Nephrosclerosis 12.60 11.74 31 369543 890 31326880
Anticoagulation drug level above therapeutic 12.58 11.74 50 369524 1869 31325901
Movement disorder 12.58 11.74 76 369498 10943 31316827
Mydriasis 12.57 11.74 37 369537 6515 31321255
Blood potassium abnormal 12.54 11.74 36 369538 1136 31326634
Muscle rigidity 12.52 11.74 66 369508 9831 31317939
Gastrointestinal arteriovenous malformation 12.52 11.74 18 369556 339 31327431
Anaphylactic shock 12.52 11.74 105 369469 14040 31313730
Hepatic function abnormal 12.45 11.74 594 368980 40628 31287142
Pseudo-Bartter syndrome 12.44 11.74 6 369568 19 31327751
Metastases to liver 12.41 11.74 92 369482 12635 31315135
Antipsychotic drug level below therapeutic 12.41 11.74 4 369570 2011 31325759
Glomerular filtration rate 12.40 11.74 10 369564 93 31327677
Papilloedema 12.40 11.74 7 369567 2519 31325251
Acute graft versus host disease in intestine 12.40 11.74 7 369567 2519 31325251
Impulsive behaviour 12.39 11.74 4 369570 2009 31325761
Rheumatoid nodule 12.36 11.74 8 369566 2673 31325097
Pruritus genital 12.35 11.74 23 369551 542 31327228
Confusional state 12.33 11.74 1754 367820 131580 31196190
Pulmonary function test abnormal 12.33 11.74 55 369519 2166 31325604
Kidney small 12.32 11.74 8 369566 51 31327719
Blood bicarbonate increased 12.30 11.74 21 369553 461 31327309
Hypochloraemia 12.29 11.74 23 369551 544 31327226
Anaemia folate deficiency 12.27 11.74 7 369567 34 31327736
Chronic left ventricular failure 12.21 11.74 20 369554 424 31327346
Scrotal swelling 12.20 11.74 39 369535 1307 31326463
Tendon pain 12.18 11.74 9 369565 2806 31324964
Cryptorchism 12.14 11.74 4 369570 1983 31325787
Aortic dilatation 12.14 11.74 37 369537 1208 31326562
Haematochezia 12.13 11.74 369 369205 40095 31287675
Red blood cell sedimentation rate increased 12.11 11.74 53 369521 8293 31319477
Lung disorder 12.07 11.74 476 369098 31836 31295934
Oesophageal variceal ligation 12.04 11.74 9 369565 74 31327696
Joint stiffness 12.04 11.74 68 369506 9953 31317817
Hepatic steatosis 12.03 11.74 126 369448 16113 31311657
Ectopic gastric mucosa 11.94 11.74 5 369569 10 31327760
Cystic fibrosis 11.94 11.74 4 369570 1962 31325808
Dizziness postural 11.89 11.74 108 369466 5460 31322310
Peritoneal cloudy effluent 11.89 11.74 12 369562 153 31327617
Rectal prolapse 11.88 11.74 20 369554 434 31327336
Disorganised speech 11.85 11.74 27 369547 737 31327033
Right atrial hypertrophy 11.84 11.74 24 369550 603 31327167
Degenerative aortic valve disease 11.79 11.74 6 369568 22 31327748
Cutaneous vasculitis 11.78 11.74 78 369496 3576 31324194

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 4687.39 10.55 12905 705894 461719 69747926
Cardiac failure congestive 4037.49 10.55 5864 712935 129593 70080052
Cardiac failure 3031.82 10.55 5311 713488 138230 70071415
Hyperkalaemia 2252.17 10.55 3946 714853 102645 70107000
Drug ineffective 2054.19 10.55 4024 714775 935728 69273917
Rheumatoid arthritis 1617.87 10.55 475 718324 291330 69918315
Oedema peripheral 1250.39 10.55 5097 713702 222994 69986651
Renal failure 1233.83 10.55 4466 714333 184604 70025041
Hypotension 1191.36 10.55 7585 711214 396796 69812849
International normalised ratio increased 1106.04 10.55 2494 716305 78232 70131413
Off label use 1070.85 10.55 3904 714895 739156 69470489
Hyponatraemia 1051.42 10.55 3790 715009 156297 70053348
Dyspnoea 954.12 10.55 11941 706858 758119 69451526
Completed suicide 874.47 10.55 617 718182 226518 69983127
Hypokalaemia 870.65 10.55 3117 715682 128071 70081574
Atrial fibrillation 866.75 10.55 3934 714865 180414 70029231
Drug intolerance 828.85 10.55 644 718155 225043 69984602
Hand deformity 777.57 10.55 21 718778 86461 70123184
Synovitis 755.64 10.55 189 718610 129039 70080606
Pemphigus 754.76 10.55 18 718781 83018 70126627
Infusion related reaction 751.86 10.55 543 718256 196991 70012654
Arthralgia 734.56 10.55 2628 716171 500762 69708883
Drug interaction 727.62 10.55 6460 712339 374981 69834664
Arthropathy 723.50 10.55 307 718492 149750 70059895
Therapeutic product effect decreased 711.62 10.55 279 718520 142739 70066906
Treatment failure 704.45 10.55 289 718510 143853 70065792
Bradycardia 672.55 10.55 2773 716026 121842 70087803
Blood creatinine increased 651.30 10.55 3024 715775 139977 70069668
Renal impairment 648.36 10.55 3034 715765 140903 70068742
Fluid retention 648.12 10.55 1751 717048 61634 70148011
Alopecia 647.99 10.55 633 718166 197857 70011788
Anaemia 646.48 10.55 6585 712214 396838 69812807
Glossodynia 615.09 10.55 76 718723 86411 70123234
Pulmonary hypertension 614.15 10.55 1417 717382 45119 70164526
Joint swelling 614.15 10.55 1012 717787 252199 69957446
Dehydration 607.20 10.55 4148 714651 221994 69987651
Oedema 595.57 10.55 2351 716448 101230 70108415
Drug hypersensitivity 593.81 10.55 1096 717703 261363 69948282
Melaena 574.35 10.55 1555 717244 54800 70154845
Contraindicated product administered 570.86 10.55 327 718472 134285 70075360
Systemic lupus erythematosus 561.95 10.55 167 718632 101735 70107910
Maternal exposure during pregnancy 560.75 10.55 233 718566 115112 70094533
Blood urea increased 560.35 10.55 1356 717443 44553 70165092
Hypersensitivity 554.91 10.55 921 717878 228891 69980754
Fall 554.84 10.55 6904 711895 437192 69772453
Drug abuse 540.63 10.55 420 718379 146836 70062809
Myocardial infarction 535.79 10.55 3271 715528 168374 70041271
Pain 526.89 10.55 3972 714827 624844 69584801
Cardiac failure chronic 520.66 10.55 580 718219 9689 70199956
Gastrointestinal haemorrhage 502.25 10.55 2731 716068 134677 70074968
Orthostatic hypotension 476.35 10.55 1376 717423 50367 70159278
Syncope 472.49 10.55 3086 715713 162623 70047022
Pericarditis 472.21 10.55 136 718663 84569 70125076
Musculoskeletal stiffness 472.04 10.55 480 718319 147280 70062365
Rheumatoid factor positive 458.23 10.55 6 718793 48394 70161251
Right ventricular failure 454.75 10.55 813 717986 21461 70188184
Duodenal ulcer perforation 436.35 10.55 19 718780 51093 70158552
Abdominal discomfort 433.57 10.55 957 717842 213701 69995944
Ascites 433.40 10.55 1588 717211 65959 70143686
Pulmonary arterial hypertension 425.33 10.55 993 717806 31862 70177783
Pulmonary oedema 421.93 10.55 1803 716996 80475 70129170
Hypervolaemia 421.09 10.55 1112 717687 38594 70171051
Hypoglycaemia 419.50 10.55 1982 716817 92382 70117263
Lactic acidosis 413.25 10.55 1524 717275 63500 70146145
Rash 399.69 10.55 3284 715515 507278 69702367
Chronic kidney disease 393.88 10.55 1438 717361 59619 70150026
Product use issue 393.04 10.55 767 718032 179170 70030475
Hepatic encephalopathy 392.32 10.55 760 718039 21358 70188287
Pleural effusion 391.94 10.55 2496 716303 130368 70079277
Sinusitis 390.95 10.55 697 718102 168498 70041147
Helicobacter infection 385.87 10.55 53 718746 55603 70154042
Discomfort 385.31 10.55 302 718497 105134 70104511
Hepatic enzyme increased 384.52 10.55 623 718176 156367 70053278
Nasopharyngitis 363.26 10.55 1102 717697 221104 69988541
Injection site pain 361.14 10.55 395 718404 117224 70092421
Psoriatic arthropathy 339.55 10.55 116 718683 64655 70144990
Therapeutic product effect incomplete 337.68 10.55 431 718368 119451 70090194
Intentional overdose 335.04 10.55 302 718497 98133 70111512
Product use in unapproved indication 331.28 10.55 1040 717759 206438 70003207
Intentional product use issue 320.05 10.55 450 718349 119692 70089953
Wound 316.09 10.55 320 718479 98412 70111233
Sleep disorder due to general medical condition, insomnia type 312.76 10.55 11 718788 35721 70173924
Suicide attempt 309.61 10.55 213 718586 79297 70130348
Injection site erythema 307.85 10.55 178 718621 72746 70136899
Folliculitis 301.20 10.55 38 718761 42532 70167113
Metabolic alkalosis 296.78 10.55 281 718518 3835 70205810
Muscle injury 293.78 10.55 26 718773 38468 70171177
Ventricular tachycardia 289.53 10.55 920 717879 35503 70174142
Cardiac failure acute 283.83 10.55 579 718220 16908 70192737
Torsade de pointes 280.15 10.55 588 718211 17528 70192117
Injection site reaction 268.83 10.55 85 718714 49767 70159878
Coronary artery disease 265.94 10.55 1300 717499 61436 70148209
Toxicity to various agents 264.82 10.55 2535 716264 379637 69830008
Headache 263.28 10.55 4218 714581 576187 69633458
Irritable bowel syndrome 263.21 10.55 93 718706 50757 70158888
Fatigue 251.13 10.55 6401 712398 817918 69391727
Rectal haemorrhage 241.39 10.55 1310 717489 64521 70145124
Dyspnoea exertional 240.24 10.55 1488 717311 76942 70132703
Orthopnoea 236.69 10.55 377 718422 9031 70200614
Generalised oedema 236.31 10.55 614 718185 21094 70188551
Rhabdomyolysis 228.40 10.55 1708 717091 94052 70115593
Respiratory failure 227.69 10.55 2664 716135 166071 70043574
Gastrointestinal disorder 226.99 10.55 453 718346 104974 70104671
Chronic obstructive pulmonary disease 224.15 10.55 1451 717348 76190 70133455
Hypovolaemia 218.70 10.55 494 718305 15499 70194146
Exposure during pregnancy 218.56 10.55 344 718455 87373 70122272
Urticaria 218.34 10.55 880 717919 162169 70047476
Haematoma 216.55 10.55 1019 717780 47399 70162246
Psoriasis 210.15 10.55 425 718374 98008 70111637
Infection 208.37 10.55 1266 717533 209519 70000126
Mitral valve incompetence 206.86 10.55 669 718130 26059 70183586
Acute myocardial infarction 206.04 10.55 1355 717444 71532 70138113
Stomatitis 205.84 10.55 643 718156 127868 70081777
Shock haemorrhagic 204.20 10.55 519 718280 17587 70192058
Cardioactive drug level increased 202.99 10.55 214 718585 3348 70206297
Injection site swelling 198.92 10.55 94 718705 43063 70166582
Urine output decreased 196.15 10.55 491 718308 16479 70193166
N-terminal prohormone brain natriuretic peptide increased 194.41 10.55 219 718580 3705 70205940
Creatinine renal clearance decreased 191.87 10.55 491 718308 16709 70192936
Blood potassium increased 191.10 10.55 661 718138 26665 70182980
Nausea 185.86 10.55 6916 711883 845172 69364473
Haemoglobin decreased 184.16 10.55 3012 715787 202147 70007498
Impaired healing 181.20 10.55 296 718503 74078 70135567
Cardiomegaly 178.90 10.55 602 718197 23943 70185702
Febrile neutropenia 178.77 10.55 1273 717526 203045 70006600
Brain natriuretic peptide increased 178.12 10.55 307 718492 7864 70201781
Hypernatraemia 177.66 10.55 397 718402 12364 70197281
Abortion spontaneous 174.86 10.55 29 718770 26450 70183195
Suicidal ideation 174.26 10.55 272 718527 69324 70140321
C-reactive protein abnormal 173.29 10.55 87 718712 38492 70171153
Renal injury 172.91 10.55 453 718346 15641 70194004
Electrocardiogram QT prolonged 172.42 10.55 1441 717358 82076 70127569
Presyncope 170.41 10.55 792 718007 36646 70172999
Pneumonia 169.95 10.55 7524 711275 588708 69620937
Red blood cell sedimentation rate abnormal 168.74 10.55 6 718793 19297 70190348
Injection site pruritus 167.92 10.55 94 718705 39116 70170529
Device expulsion 167.15 10.55 16 718783 22230 70187415
Gout 163.93 10.55 560 718239 22446 70187199
Hepatic failure 163.90 10.55 1073 717726 56552 70153093
Asthenia 162.71 10.55 5915 712884 451751 69757894
Sopor 160.06 10.55 685 718114 30582 70179063
Ill-defined disorder 158.07 10.55 193 718606 54548 70155097
Rheumatic fever 156.10 10.55 5 718794 17655 70191990
Hypoxia 155.24 10.55 1537 717262 91807 70117838
Anuria 153.97 10.55 494 718305 19159 70190486
Multiple sclerosis relapse 152.38 10.55 127 718672 42890 70166755
Transfusion 151.72 10.55 478 718321 18358 70191287
Pyrexia 148.92 10.55 4853 713946 602099 69607546
Acute pulmonary oedema 148.71 10.55 382 718417 13030 70196615
Blood pressure decreased 147.90 10.55 1498 717301 90017 70119628
Swelling 147.79 10.55 1211 717588 187328 70022317
Cardiac disorder 146.90 10.55 1069 717730 58346 70151299
Injection site bruising 146.56 10.55 103 718696 37929 70171716
Red blood cell sedimentation rate increased 145.84 10.55 107 718692 38535 70171110
Cardiogenic shock 145.10 10.55 740 718059 35567 70174078
Ischaemic cardiomyopathy 144.61 10.55 259 718540 6845 70202800
Neutropenia 144.16 10.55 1790 717009 255366 69954279
Ejection fraction decreased 143.87 10.55 656 718143 30106 70179539
Epistaxis 137.32 10.55 1618 717181 101009 70108636
Colitis ulcerative 135.91 10.55 88 718711 33835 70175810
COVID-19 134.56 10.55 582 718217 105175 70104470
Pregnancy 132.84 10.55 38 718761 23743 70185902
Rales 132.69 10.55 429 718370 16706 70192939
Intentional product misuse 132.60 10.55 391 718408 79204 70130441
Tricuspid valve incompetence 132.52 10.55 440 718359 17377 70192268
Loss of personal independence in daily activities 131.63 10.55 431 718368 84479 70125166
Atrioventricular block 130.10 10.55 351 718448 12337 70197308
Hypocalcaemia 129.83 10.55 839 717960 44020 70165625
Blood potassium decreased 129.34 10.55 804 717995 41617 70168028
Multiple organ dysfunction syndrome 127.21 10.55 1669 717130 106846 70102799
Subdural haematoma 126.92 10.55 611 718188 28687 70180958
Hypoaesthesia 126.71 10.55 974 717825 152765 70056880
Congestive cardiomyopathy 125.09 10.55 315 718484 10611 70199034
Drug ineffective for unapproved indication 124.34 10.55 124 718675 38414 70171231
Accidental exposure to product 123.40 10.55 65 718734 27986 70181659
Acute respiratory failure 123.31 10.55 949 717850 52716 70156929
Sleep disorder 123.21 10.55 334 718465 69538 70140107
Lower respiratory tract infection 123.04 10.55 649 718150 111264 70098381
Inappropriate schedule of product administration 122.03 10.55 617 718182 106938 70102707
Drug resistance 121.93 10.55 124 718675 38066 70171579
Glomerular filtration rate decreased 121.50 10.55 474 718325 20282 70189363
Hip arthroplasty 118.95 10.55 68 718731 27972 70181673
Hypomagnesaemia 118.95 10.55 764 718035 40000 70169645
Psychotic disorder 118.58 10.55 124 718675 37577 70172068
Oliguria 117.61 10.55 378 718421 14673 70194972
Nephrocalcinosis 117.30 10.55 104 718695 1297 70208348
Cardiomyopathy 117.14 10.55 554 718245 25819 70183826
Toxic epidermal necrolysis 117.04 10.55 744 718055 38813 70170832
Atrial flutter 116.40 10.55 461 718338 19866 70189779
Haematuria 116.20 10.55 1068 717731 62505 70147140
Pemphigoid 114.92 10.55 358 718441 13664 70195981
Haematemesis 113.84 10.55 866 717933 47931 70161714
Migraine 113.83 10.55 364 718435 71874 70137771
Anaphylactic reaction 113.17 10.55 385 718414 74589 70135056
Left ventricular failure 113.16 10.55 264 718535 8464 70201181
Night sweats 112.95 10.55 167 718632 43517 70166128
Pericardial effusion 112.84 10.55 768 718031 41008 70168637
Knee arthroplasty 112.24 10.55 109 718690 34192 70175453
Rheumatoid nodule 110.18 10.55 12 718787 15055 70194590
Death 108.05 10.55 6257 712542 503804 69705841
Paraesthesia 107.20 10.55 950 717849 144587 70065058
Arrhythmia 107.11 10.55 952 717847 55191 70154454
Gravitational oedema 106.56 10.55 109 718690 1643 70208002
Pseudo-Bartter syndrome 105.90 10.55 38 718761 49 70209596
Adverse drug reaction 104.96 10.55 241 718558 53103 70156542
Azotaemia 104.36 10.55 238 718561 7515 70202130
Asthma 103.93 10.55 756 718043 120037 70089608
Mucosal inflammation 103.37 10.55 347 718452 67503 70142142
Cardiac arrest 103.32 10.55 2231 716568 157603 70052042
Insomnia 102.35 10.55 1571 717228 216235 69993410
Arthritis 102.31 10.55 578 718221 97402 70112243
Tenosynovitis 100.03 10.55 12 718787 13964 70195681
Hyperuricaemia 99.31 10.55 290 718509 10676 70198969
Blood calcium decreased 97.72 10.55 562 718237 28284 70181361
Aortic stenosis 96.82 10.55 210 718589 6406 70203239
Cerebrovascular accident 96.74 10.55 2015 716784 141455 70068190
Pruritus 96.60 10.55 2714 716085 342846 69866799
Immune reconstitution inflammatory syndrome 95.88 10.55 10 718789 12980 70196665
Myocardial ischaemia 95.83 10.55 492 718307 23708 70185937
Haemodialysis 95.56 10.55 389 718410 16977 70192668
Atrioventricular block complete 94.28 10.55 353 718446 14810 70194835
Musculoskeletal pain 94.23 10.55 533 718266 89794 70119851
Intentional self-injury 94.13 10.55 109 718690 31541 70178104
Blood loss anaemia 92.98 10.55 340 718459 14101 70195544
Product dose omission issue 92.75 10.55 1597 717202 215871 69993774
Coronary artery bypass 92.52 10.55 193 718606 5727 70203918
Bradyarrhythmia 92.10 10.55 153 718646 3800 70205845
Grip strength decreased 91.51 10.55 23 718776 15662 70193983
Sedation complication 89.97 10.55 320 718479 13090 70196555
Haemoptysis 89.83 10.55 856 717943 50596 70159049
Fear 89.41 10.55 433 718366 20378 70189267
Iron deficiency anaemia 89.23 10.55 466 718333 22606 70187039
Therapeutic response decreased 89.01 10.55 299 718500 58154 70151491
Infective pulmonary exacerbation of cystic fibrosis 88.11 10.55 10 718789 12148 70197497
Seizure 87.59 10.55 1272 717527 176690 70032955
Schizophrenia 86.20 10.55 31 718768 16737 70192908
Upper gastrointestinal haemorrhage 85.68 10.55 662 718137 36815 70172830
Bone erosion 85.20 10.55 24 718775 15149 70194496
Respiratory distress 85.14 10.55 888 717911 53762 70155883
Dialysis 85.05 10.55 376 718423 17026 70192619
Uveitis 84.26 10.55 23 718776 14822 70194823
Haematotoxicity 83.85 10.55 18 718781 13656 70195989
Inflammation 83.24 10.55 462 718337 78203 70131442
Blood cholesterol increased 82.48 10.55 355 718444 64249 70145396
Foot deformity 82.17 10.55 54 718745 20601 70189044
Concomitant disease aggravated 82.07 10.55 290 718509 11824 70197821
Blood sodium decreased 82.01 10.55 567 718232 30431 70179214
Hypochloraemia 81.88 10.55 105 718694 2046 70207599
Blood bilirubin increased 81.70 10.55 948 717851 58953 70150692
Unevaluable event 81.13 10.55 846 717953 51217 70158428
Joint stiffness 81.08 10.55 145 718654 35031 70174614
Cardiac output decreased 80.95 10.55 94 718705 1646 70207999
Therapeutic response shortened 80.58 10.55 16 718783 12822 70196823
Venous pressure jugular increased 80.48 10.55 82 718717 1230 70208415
Depression 80.13 10.55 1476 717323 197498 70012147
Impaired work ability 79.38 10.55 33 718766 16307 70193338
Bundle branch block left 79.30 10.55 259 718540 10140 70199505
Aortic valve incompetence 79.23 10.55 234 718565 8670 70200975
Polyuria 77.53 10.55 305 718494 13101 70196544
Multiple sclerosis 77.47 10.55 85 718714 25200 70184445
Toxic skin eruption 77.13 10.55 406 718393 19756 70189889
Oropharyngeal pain 77.07 10.55 615 718184 95695 70113950
Prothrombin time prolonged 77.01 10.55 347 718452 15843 70193802
Jugular vein distension 76.74 10.55 81 718718 1269 70208376
Device issue 76.71 10.55 78 718721 23947 70185698
Fibromyalgia 76.28 10.55 240 718559 47634 70162011
Prerenal failure 76.15 10.55 129 718670 3257 70206388
Blood pressure fluctuation 76.12 10.55 323 718476 58689 70150956
Blister 74.09 10.55 656 718143 99870 70109775
Depressed level of consciousness 73.36 10.55 1270 717529 86161 70123484
Cellulitis 73.20 10.55 1409 717390 97519 70112126
International normalised ratio decreased 73.06 10.55 206 718593 7432 70202213
Confusional state 72.75 10.55 3552 715247 280846 69928799
Pulmonary arterial pressure increased 72.69 10.55 145 718654 4164 70205481
Hepatic cirrhosis 72.58 10.55 547 718252 30184 70179461
Ischaemic stroke 72.46 10.55 548 718251 30272 70179373
Left ventricular dysfunction 71.05 10.55 365 718434 17592 70192053
Lower gastrointestinal haemorrhage 70.39 10.55 316 718483 14404 70195241
Osteoarthritis 70.25 10.55 451 718348 73696 70135949
Concomitant disease progression 70.23 10.55 123 718676 3192 70206453
Progressive multifocal leukoencephalopathy 70.20 10.55 55 718744 19159 70190486
Ankylosing spondylitis 70.06 10.55 16 718783 11630 70198015
Eosinophilia 69.99 10.55 670 718129 39649 70169996
Muscle spasticity 69.88 10.55 58 718741 19631 70190014
Congestive hepatopathy 69.82 10.55 138 718661 3936 70205709
Prostate cancer 69.56 10.55 131 718668 31032 70178613
Cardiac murmur 69.47 10.55 276 718523 11910 70197735
Anhedonia 69.39 10.55 307 718492 13906 70195739
Hypoglycaemic coma 69.12 10.55 143 718656 4218 70205427
Pulmonary congestion 68.86 10.55 464 718335 24690 70184955
Injection site warmth 68.66 10.55 27 718772 13798 70195847
Metabolic acidosis 68.65 10.55 1097 717702 73249 70136396
Serotonin syndrome 68.61 10.55 209 718590 41905 70167740
Poisoning 68.26 10.55 77 718722 22545 70187100
Neuropathy peripheral 66.69 10.55 895 717904 126001 70083644
Oesophageal varices haemorrhage 66.60 10.55 130 718669 3673 70205972
Anxiety 66.57 10.55 1711 717088 218619 69991026
Cerebral haemorrhage 66.27 10.55 836 717963 53028 70156617
Dilatation ventricular 65.98 10.55 132 718667 3799 70205846
Injection site rash 65.15 10.55 43 718756 16367 70193278
Vitamin B1 deficiency 65.12 10.55 53 718746 583 70209062
Oral herpes 64.95 10.55 90 718709 24096 70185549
Exercise tolerance decreased 64.31 10.55 207 718592 8041 70201604
Ventricular fibrillation 64.27 10.55 483 718316 26628 70183017
Electrolyte imbalance 63.37 10.55 478 718321 26383 70183262
Sudden death 62.19 10.55 396 718403 20668 70188977
Live birth 61.99 10.55 31 718768 13748 70195897
Tendonitis 61.77 10.55 80 718719 22042 70187603
Dilatation atrial 61.44 10.55 120 718679 3392 70206253
Dyspnoea paroxysmal nocturnal 61.29 10.55 90 718709 2003 70207642
Cor pulmonale 60.96 10.55 90 718709 2013 70207632
Hyponatraemic syndrome 60.64 10.55 55 718744 708 70208937
Throat irritation 60.56 10.55 171 718628 35133 70174512
Dry eye 59.43 10.55 151 718648 32131 70177514
Acne 59.42 10.55 101 718698 24888 70184757
Blood parathyroid hormone decreased 59.32 10.55 10 718789 9014 70200631
Head injury 59.09 10.55 567 718232 33574 70176071
Ventricular extrasystoles 59.08 10.55 351 718448 17875 70191770
Blood alkaline phosphatase increased 58.82 10.55 876 717923 57645 70152000
International normalised ratio abnormal 58.74 10.55 150 718649 5097 70204548
Blood creatine increased 58.68 10.55 209 718590 8555 70201090
Neoplasm progression 58.67 10.55 247 718552 44981 70164664
Myelosuppression 58.65 10.55 137 718662 30008 70179637
Vascular purpura 58.32 10.55 102 718697 2644 70207001
Hypovolaemic shock 58.24 10.55 241 718558 10596 70199049
Faeces discoloured 58.22 10.55 468 718331 26341 70183304
Drug tolerance decreased 58.18 10.55 14 718785 9819 70199826
Diastolic dysfunction 58.15 10.55 219 718580 9214 70200431
Device difficult to use 57.60 10.55 19 718780 10830 70198815
Injection site urticaria 57.35 10.55 23 718776 11615 70198030
Poor venous access 57.08 10.55 41 718758 14930 70194715
Unintentional medical device removal 56.63 10.55 4 718795 7120 70202525
Irritability 56.52 10.55 198 718601 38027 70171618
Back pain 56.45 10.55 2211 716588 268941 69940704
Bone density decreased 56.01 10.55 23 718776 11451 70198194
Microcytic anaemia 55.80 10.55 139 718660 4650 70204995
Wrong technique in product usage process 55.73 10.55 437 718362 68261 70141384
Dystonia 55.29 10.55 71 718728 19635 70190010
Fear of injection 55.27 10.55 3 718796 6669 70202976
Basal cell carcinoma 55.06 10.55 167 718632 33531 70176114
Drug withdrawal syndrome 54.99 10.55 160 718639 32555 70177090
Joint range of motion decreased 54.99 10.55 113 718686 25913 70183732
Chest pain 54.90 10.55 3092 715707 248168 69961477
Bursitis 54.52 10.55 118 718681 26555 70183090
Osteoporosis 54.07 10.55 283 718516 48624 70161021
Troponin increased 53.88 10.55 320 718479 16294 70193351
Hepatorenal syndrome 53.85 10.55 122 718677 3835 70205810
Malignant neoplasm progression 53.81 10.55 888 717911 120851 70088794
Ovarian cyst 53.69 10.55 26 718773 11746 70197899
Neutrophil count decreased 53.63 10.55 564 718235 82992 70126653
Nephrotic syndrome 53.60 10.55 232 718567 10408 70199237
Suspected suicide 53.41 10.55 12 718787 8822 70200823
Therapy partial responder 53.27 10.55 30 718769 12444 70197201
Muscle haemorrhage 52.70 10.55 155 718644 5729 70203916
Substance abuse 52.62 10.55 17 718782 9820 70199825
Activated partial thromboplastin time prolonged 52.38 10.55 273 718526 13232 70196413
Lip dry 52.19 10.55 17 718782 9768 70199877
Breast cancer 52.18 10.55 170 718629 33379 70176266
Angina pectoris 52.09 10.55 733 718066 47650 70161995
Aggression 52.08 10.55 283 718516 48163 70161482
Low cardiac output syndrome 52.07 10.55 54 718745 828 70208817
Paradoxical drug reaction 51.96 10.55 4 718795 6632 70203013
Encephalopathy 51.47 10.55 895 717904 60766 70148879
Sepsis 51.43 10.55 2999 715800 241546 69968099
Generalised tonic-clonic seizure 51.32 10.55 232 718567 41429 70168216
Gastrointestinal tract mucosal pigmentation 51.31 10.55 56 718743 913 70208732
Coeliac disease 51.26 10.55 14 718785 9019 70200626
Cytomegalovirus infection 51.04 10.55 218 718581 39540 70170105
Disability 50.92 10.55 46 718753 14937 70194708
Ventricular dysfunction 50.56 10.55 148 718651 5456 70204189
Appendicitis 50.44 10.55 57 718742 16676 70192969
Drug dependence 50.17 10.55 201 718598 37120 70172525
Pathogen resistance 49.80 10.55 37 718762 13242 70196403
Sinus node dysfunction 49.76 10.55 173 718626 6996 70202649
Injection site haemorrhage 49.67 10.55 116 718683 25411 70184234
Immunodeficiency 49.51 10.55 63 718736 17492 70192153
Adverse event 49.36 10.55 296 718503 49165 70160480
Blood pressure increased 48.98 10.55 1495 717304 187022 70022623
Visual impairment 48.97 10.55 548 718251 79702 70129943
Herpes zoster 48.93 10.55 590 718209 84645 70125000
Angina unstable 48.92 10.55 302 718497 15591 70194054
Acute graft versus host disease 48.61 10.55 18 718781 9544 70200101
Cataract 48.45 10.55 347 718452 55298 70154347
Hepatotoxicity 48.36 10.55 255 718544 43731 70165914
Musculoskeletal disorder 48.15 10.55 80 718719 19891 70189754
Atrioventricular block first degree 48.09 10.55 240 718559 11433 70198212
Ear infection 48.05 10.55 138 718661 28198 70181447
Drug reaction with eosinophilia and systemic symptoms 47.69 10.55 840 717959 57173 70152472
Eye pain 47.55 10.55 181 718618 33921 70175724
Liver injury 47.32 10.55 234 718565 40801 70168844
Mood swings 47.17 10.55 70 718729 18216 70191429
Coronary arterial stent insertion 47.04 10.55 149 718650 5738 70203907
Facet joint syndrome 46.99 10.55 4 718795 6109 70203536
Breast cancer stage I 46.89 10.55 4 718795 6098 70203547
Juvenile idiopathic arthritis 46.86 10.55 3 718796 5797 70203848
Panniculitis 46.57 10.55 25 718774 10651 70198994
Colitis 46.32 10.55 418 718381 63396 70146249
Erythema 46.28 10.55 1606 717193 197957 70011688
Influenza like illness 46.10 10.55 431 718368 64900 70144745
Gestational diabetes 45.93 10.55 4 718795 5997 70203648
Neutropenic sepsis 45.82 10.55 116 718683 24714 70184931
Abdominal pain 45.51 10.55 2922 715877 339205 69870440
Depressed mood 45.46 10.55 259 718540 43561 70166084
Cardiac valve disease 45.33 10.55 139 718660 5259 70204386
Hypercreatininaemia 45.33 10.55 49 718750 790 70208855
Loss of consciousness 45.19 10.55 1970 716829 153746 70055899
Uterine perforation 44.89 10.55 4 718795 5887 70203758
Neck pain 44.81 10.55 445 718354 66212 70143433
Photophobia 44.69 10.55 75 718724 18575 70191070
Renal disorder 44.68 10.55 585 718214 37424 70172221
Jaundice 44.63 10.55 735 718064 49373 70160272
Nodule 44.52 10.55 84 718715 19885 70189760
Pain in extremity 44.50 10.55 2797 716002 325285 69884360
Blood uric acid increased 44.42 10.55 197 718602 8932 70200713
Dyspnoea at rest 44.28 10.55 161 718638 6658 70202987
Sinus bradycardia 44.24 10.55 399 718400 23224 70186421
Post transplant lymphoproliferative disorder 44.12 10.55 26 718773 10519 70199126
Abdominal wall haematoma 43.87 10.55 121 718678 4309 70205336
Pericardial haemorrhage 43.69 10.55 118 718681 4150 70205495
Breast cancer female 43.67 10.55 26 718773 10460 70199185
Impaired quality of life 43.32 10.55 18 718781 8898 70200747
Occult blood positive 42.99 10.55 153 718646 6260 70203385
Hepatic function abnormal 42.90 10.55 946 717853 67050 70142595
Dermatitis exfoliative 42.81 10.55 216 718583 10335 70199310
Device use error 42.76 10.55 8 718791 6688 70202957
Exposure to toxic agent 42.69 10.55 6 718793 6188 70203457
Ecchymosis 42.66 10.55 270 718529 14062 70195583
Subcutaneous haematoma 42.57 10.55 86 718713 2493 70207152
Multiple-drug resistance 42.49 10.55 11 718788 7344 70202301
Ischaemic hepatitis 42.40 10.55 100 718699 3229 70206416
Poisoning deliberate 42.38 10.55 67 718732 16993 70192652
C-reactive protein increased 42.25 10.55 827 717972 109690 70099955
Injection site mass 41.92 10.55 76 718723 18267 70191378
Disease recurrence 41.90 10.55 217 718582 37386 70172259
Lymphadenopathy 41.64 10.55 306 718493 48485 70161160
Hypocoagulable state 41.53 10.55 73 718726 1900 70207745
Abdominal pain upper 41.50 10.55 1573 717226 192029 70017616
Nightmare 41.28 10.55 103 718696 22053 70187592
Frequent bowel movements 41.26 10.55 96 718703 21057 70188588
Balance disorder 41.22 10.55 1201 717598 88927 70120718
Product storage error 41.20 10.55 52 718747 14489 70195156
Catheter management 40.94 10.55 101 718698 3358 70206287
White blood cell count decreased 40.89 10.55 1363 717436 168778 70040867
No adverse event 40.84 10.55 177 718622 31976 70177669
Acute graft versus host disease in skin 40.61 10.55 11 718788 7126 70202519
Laryngitis 40.47 10.55 47 718752 13584 70196061
Drug use disorder 40.34 10.55 16 718783 8135 70201510
Arteriosclerosis 40.33 10.55 298 718501 16340 70193305
Neuroleptic malignant syndrome 40.30 10.55 132 718667 25875 70183770
Urinary tract discomfort 40.16 10.55 35 718764 426 70209219
Oxygen consumption increased 39.76 10.55 121 718678 4559 70205086
Cholestasis 39.65 10.55 694 718105 47178 70162467
Cardiac pacemaker insertion 39.36 10.55 132 718667 5240 70204405
Hypercalciuria 39.23 10.55 36 718763 471 70209174
Upper respiratory tract infection 39.19 10.55 566 718233 78708 70130937
Device interaction 39.15 10.55 42 718757 671 70208974
Arteriospasm coronary 38.89 10.55 7 718792 6017 70203628
Intra-abdominal haematoma 38.88 10.55 85 718714 2607 70207038
Left ventricular dilatation 38.84 10.55 50 718749 978 70208667
Peritonitis bacterial 38.67 10.55 190 718609 8994 70200651
Peripartum cardiomyopathy 38.59 10.55 22 718777 126 70209519
Hypercapnia 38.48 10.55 177 718622 8152 70201493
Vascular graft 38.45 10.55 70 718729 1874 70207771
Gastric disorder 38.44 10.55 190 718609 33132 70176513
Circulatory collapse 38.42 10.55 538 718261 34936 70174709
Myopathy 38.31 10.55 321 718478 18291 70191354
Tuberculosis 38.15 10.55 57 718742 14791 70194854
Tachyarrhythmia 37.56 10.55 146 718653 6236 70203409
Haemophagocytic lymphohistiocytosis 37.46 10.55 90 718709 19522 70190123
Pseudoporphyria 37.22 10.55 37 718762 538 70209107
Nodal rhythm 37.08 10.55 88 718711 2853 70206792
Muscle twitching 37.07 10.55 92 718707 19735 70189910
Tooth infection 36.92 10.55 69 718730 16394 70193251
Superinfection 36.91 10.55 110 718689 4096 70205549
Chills 36.91 10.55 1151 717648 143635 70066010
Type 2 diabetes mellitus 36.88 10.55 278 718521 43802 70165843
Crying 36.86 10.55 102 718697 21097 70188548
Tongue disorder 36.76 10.55 48 718751 13179 70196466
Oxygen saturation decreased 36.72 10.55 1486 717313 114943 70094702
Incorrect route of product administration 36.68 10.55 141 718658 26351 70183294
Heparin-induced thrombocytopenia 36.67 10.55 185 718614 8852 70200793
Medication error 36.60 10.55 794 718005 56118 70153527
Disorientation 36.58 10.55 806 717993 57117 70152528
Paranoia 36.57 10.55 75 718724 17213 70192432
Device dislocation 36.44 10.55 112 718687 22395 70187250
Coagulopathy 36.31 10.55 505 718294 32744 70176901
Diabetic ketoacidosis 36.16 10.55 180 718619 31332 70178313
Mucormycosis 36.10 10.55 18 718781 7996 70201649
Normochromic normocytic anaemia 36.04 10.55 154 718645 6869 70202776
Hepatocellular carcinoma 35.97 10.55 201 718598 10007 70199638
Dermatitis bullous 35.93 10.55 237 718562 12520 70197125
Central nervous system lesion 35.84 10.55 44 718755 12409 70197236
Alkalosis 35.73 10.55 34 718765 467 70209178
Gastritis erosive 35.72 10.55 199 718600 9896 70199749
Anticoagulation drug level above therapeutic 35.66 10.55 92 718707 3146 70206499
Bundle branch block right 35.47 10.55 206 718593 10404 70199241
Blood creatinine abnormal 35.45 10.55 112 718687 4307 70205338
Feeling abnormal 35.41 10.55 1135 717664 141184 70068461
Pharyngitis 35.33 10.55 98 718701 20253 70189392
Hypersensitivity vasculitis 35.33 10.55 150 718649 6672 70202973
Shock 35.27 10.55 591 718208 39834 70169811
Mania 35.08 10.55 76 718723 17098 70192547
Breast cancer stage II 34.98 10.55 6 718793 5340 70204305
Alanine aminotransferase abnormal 34.97 10.55 19 718780 8040 70201605
Blood pressure diastolic abnormal 34.76 10.55 65 718734 15439 70194206
Cardiorenal syndrome 34.75 10.55 58 718741 1446 70208199
Bone pain 34.70 10.55 338 718461 50484 70159161
Blood albumin decreased 34.67 10.55 360 718439 21767 70187878
Renal tubular necrosis 34.44 10.55 373 718426 22798 70186847
Ventricular arrhythmia 34.42 10.55 164 718635 7666 70201979
Anal abscess 34.42 10.55 21 718778 8337 70201308
Hypoalbuminaemia 34.30 10.55 320 718479 18802 70190843
Myoclonus 34.12 10.55 413 718386 25942 70183703
Chronic graft versus host disease 33.99 10.55 13 718786 6757 70202888
Lupus-like syndrome 33.87 10.55 40 718759 11475 70198170
Muscle spasms 33.59 10.55 1249 717550 152797 70056848
Polyomavirus-associated nephropathy 33.51 10.55 6 718793 5177 70204468
Sciatica 33.51 10.55 132 718667 24495 70185150
Left ventricular hypertrophy 33.40 10.55 197 718602 10005 70199640
Mydriasis 33.39 10.55 71 718728 16082 70193563
Tardive dyskinesia 33.13 10.55 31 718768 9898 70199747
Dry mouth 33.11 10.55 508 718291 69949 70139696
Pelvic pain 33.11 10.55 41 718758 11519 70198126
Memory impairment 33.09 10.55 701 718098 91940 70117705
Nephrogenic anaemia 33.07 10.55 96 718703 3522 70206123
Nephrolithiasis 33.04 10.55 313 718486 47010 70162635
Cardio-respiratory arrest 32.92 10.55 1290 717509 99387 70110258
Renal artery stenosis 32.82 10.55 90 718709 3194 70206451
Emotional disorder 32.80 10.55 52 718747 13174 70196471
Graft versus host disease 32.79 10.55 64 718735 14959 70194686
Amnesia 32.67 10.55 354 718445 51801 70157844
Epstein-Barr virus infection 32.63 10.55 52 718747 13146 70196499
Ear pain 32.63 10.55 156 718643 27443 70182202
Hypophagia 32.43 10.55 597 718202 40973 70168672
Acrodermatitis enteropathica 32.42 10.55 9 718790 0 70209645
Ocular hyperaemia 32.30 10.55 134 718665 24505 70185140
Feeling hot 32.26 10.55 326 718473 48344 70161301
Right-to-left cardiac shunt 32.24 10.55 24 718775 229 70209416
Spontaneous haematoma 32.16 10.55 52 718747 1262 70208383
Diabetes mellitus inadequate control 32.04 10.55 361 718438 22284 70187361
Arteriosclerosis coronary artery 31.98 10.55 277 718522 15938 70193707
Paracentesis 31.85 10.55 51 718748 1227 70208418
Asterixis 31.66 10.55 74 718725 2375 70207270
Agranulocytosis 31.53 10.55 579 718220 39719 70169926
Atrial tachycardia 31.43 10.55 96 718703 3624 70206021
Diffuse large B-cell lymphoma 31.41 10.55 54 718745 13248 70196397
Cerebral haematoma 31.33 10.55 153 718646 7225 70202420
Abdominal cavity drainage 31.29 10.55 38 718761 699 70208946
Blood iron decreased 31.29 10.55 236 718563 13025 70196620
Gouty arthritis 31.26 10.55 53 718746 1339 70208306
Cardiac amyloidosis 31.26 10.55 57 718742 1528 70208117
Aspiration pleural cavity 30.98 10.55 55 718744 1443 70208202
Maternal exposure timing unspecified 30.86 10.55 4 718795 4387 70205258
Purpura 30.85 10.55 298 718501 17677 70191968
Joint dislocation 30.77 10.55 63 718736 14468 70195177
Syringe issue 30.72 10.55 8 718791 5320 70204325
Rhinorrhoea 30.70 10.55 480 718319 65891 70143754
Ventricular hypertrophy 30.48 10.55 140 718659 6444 70203201
Throat tightness 30.42 10.55 140 718659 24882 70184763
Nephrosclerosis 30.35 10.55 59 718740 1662 70207983
Mental disorder 30.33 10.55 165 718634 28075 70181570
Varices oesophageal 30.33 10.55 122 718677 5295 70204350
Septic shock 30.11 10.55 1409 717390 110849 70098796
Sexual dysfunction 30.10 10.55 15 718784 6666 70202979
Right ventricular dysfunction 30.09 10.55 71 718728 2293 70207352
Hot flush 30.09 10.55 339 718460 49245 70160400
Tachypnoea 30.08 10.55 432 718367 28206 70181439
Eye irritation 29.89 10.55 87 718712 17701 70191944
Scrotal oedema 29.84 10.55 51 718748 1297 70208348
Long QT syndrome 29.84 10.55 120 718679 5207 70204438
Haemorrhage subcutaneous 29.74 10.55 107 718692 4402 70205243
Extrapyramidal disorder 29.67 10.55 109 718690 20641 70189004
Malignant melanoma 29.66 10.55 60 718739 13840 70195805
Fungal infection 29.61 10.55 240 718559 37227 70172418
Vomiting 29.54 10.55 5427 713372 587684 69621961
Neuromyopathy 29.29 10.55 53 718746 1412 70208233
Haematocrit decreased 29.27 10.55 774 718025 56484 70153161
Hypercreatinaemia 29.20 10.55 24 718775 268 70209377
Respiratory arrest 29.19 10.55 378 718421 53555 70156090
Amenorrhoea 29.12 10.55 17 718782 6913 70202732
Hepatitis B reactivation 29.10 10.55 9 718790 5346 70204299
Mouth ulceration 29.03 10.55 216 718583 34133 70175512
Metastases to liver 29.02 10.55 149 718650 25729 70183916
Abnormal behaviour 28.99 10.55 219 718580 34490 70175155
Left ventricular enlargement 28.96 10.55 36 718763 679 70208966
Sudden cardiac death 28.95 10.55 112 718687 4773 70204872
Influenza 28.95 10.55 904 717895 112796 70096849
Ammonia increased 28.87 10.55 146 718653 6992 70202653
Mood altered 28.85 10.55 79 718720 16396 70193249
Pharyngitis streptococcal 28.68 10.55 32 718767 9416 70200229
Disturbance in attention 28.56 10.55 287 718512 42607 70167038
Ulcer 28.48 10.55 149 718650 25605 70184040
Heavy menstrual bleeding 28.48 10.55 53 718746 12612 70197033
Acute coronary syndrome 28.37 10.55 320 718479 19759 70189886
Brain natriuretic peptide abnormal 28.24 10.55 35 718764 658 70208987
Second primary malignancy 28.14 10.55 56 718743 12995 70196650
Abdominal distension 28.13 10.55 1314 717485 103355 70106290
Liver function test increased 28.06 10.55 214 718585 33633 70176012
Disturbance in social behaviour 27.89 10.55 4 718795 4063 70205582
Anger 27.77 10.55 78 718721 16054 70193591
Hyperparathyroidism secondary 27.48 10.55 72 718727 2486 70207159
Bone marrow failure 27.46 10.55 341 718458 48669 70160976
Neurotoxicity 27.44 10.55 183 718616 29643 70180002
Drug specific antibody present 27.38 10.55 12 718787 5746 70203899
Illness 27.31 10.55 199 718600 31592 70178053
Joint effusion 27.26 10.55 74 718725 15403 70194242
Synovial cyst 27.21 10.55 29 718770 8713 70200932
Gastrointestinal vascular malformation haemorrhagic 27.07 10.55 36 718763 728 70208917
Atrial thrombosis 27.04 10.55 83 718716 3142 70206503
Temperature regulation disorder 26.94 10.55 6 718793 4438 70205207
Protein total decreased 26.94 10.55 159 718640 8077 70201568
Product quality issue 26.88 10.55 190 718609 30371 70179274
Endocarditis 26.88 10.55 183 718616 9771 70199874
Prothrombin time shortened 26.83 10.55 78 718721 2864 70206781
Dermatitis atopic 26.80 10.55 31 718768 8976 70200669
Alcohol interaction 26.80 10.55 7 718792 4646 70204999
Hepatic cancer 26.73 10.55 179 718620 9504 70200141
Haemorrhage 26.71 10.55 1071 717728 82744 70126901
Blood lactic acid 26.71 10.55 28 718771 435 70209210
Right atrial dilatation 26.68 10.55 35 718764 698 70208947
Osteonecrosis of jaw 26.61 10.55 276 718523 40726 70168919
Haemorrhage intracranial 26.52 10.55 375 718424 24402 70185243
Chronic respiratory failure 26.44 10.55 74 718725 2658 70206987
Metabolic encephalopathy 26.43 10.55 160 718639 8203 70201442
Right atrial enlargement 26.27 10.55 24 718775 312 70209333
Menstruation irregular 26.24 10.55 7 718792 4581 70205064
Right ventricular hypertrophy 26.17 10.55 50 718749 1390 70208255
Cushingoid 25.91 10.55 28 718771 8360 70201285
Haematoma muscle 25.88 10.55 66 718733 2241 70207404
Blepharospasm 25.86 10.55 4 718795 3841 70205804
Gouty tophus 25.85 10.55 24 718775 319 70209326
Mitral valve thickening 25.73 10.55 26 718773 386 70209259
Middle insomnia 25.66 10.55 66 718733 13987 70195658
Chronic hepatic failure 25.62 10.55 39 718760 897 70208748
Ventricular dyssynchrony 25.60 10.55 12 718787 42 70209603
Metastases to bone 25.57 10.55 128 718671 22248 70187397
Cyanosis 25.55 10.55 353 718446 22853 70186792
Complication of device insertion 25.53 10.55 11 718788 5321 70204324
Overdose 25.49 10.55 1433 717366 168312 70041333
Paraesthesia oral 25.47 10.55 76 718723 15341 70194304
Aspergillus infection 25.45 10.55 94 718705 17774 70191871
Abscess 25.45 10.55 115 718684 20539 70189106
Withdrawal syndrome 25.40 10.55 148 718651 24756 70184889
Hypomania 25.36 10.55 15 718784 6057 70203588
Acute generalised exanthematous pustulosis 25.32 10.55 253 718546 15144 70194501
Atrial enlargement 25.31 10.55 33 718766 654 70208991
Hyperaesthesia 25.31 10.55 45 718754 10897 70198748
Catheter site infection 25.25 10.55 125 718674 5935 70203710
Joint destruction 25.17 10.55 8 718791 4670 70204975
Myoglobin blood increased 25.16 10.55 78 718721 2969 70206676
Blood pressure systolic decreased 25.05 10.55 176 718623 9495 70200150
Intraocular pressure increased 25.04 10.55 32 718767 8869 70200776
Adjustment disorder with depressed mood 25.01 10.55 6 718793 4217 70205428
Mycobacterial infection 24.95 10.55 3 718796 3485 70206160
Hypocalvaria 24.92 10.55 10 718789 21 70209624
Burning sensation 24.91 10.55 381 718418 52489 70157156
Prescribed overdose 24.89 10.55 167 718632 27014 70182631
Demyelination 24.85 10.55 22 718777 7214 70202431
Duodenal ulcer haemorrhage 24.82 10.55 134 718665 6584 70203061
Inflammatory bowel disease 24.82 10.55 10 718789 5036 70204609
Eyelid ptosis 24.79 10.55 40 718759 10062 70199583
Injection site induration 24.73 10.55 34 718765 9134 70200511
Alveolar osteitis 24.65 10.55 30 718769 553 70209092
Alkalosis hypochloraemic 24.65 10.55 27 718772 442 70209203
Akathisia 24.61 10.55 55 718744 12238 70197407
Hyperhidrosis 24.58 10.55 1086 717713 130500 70079145
Retroperitoneal haematoma 24.58 10.55 108 718691 4877 70204768
Respiratory depression 24.56 10.55 149 718650 24682 70184963
Granuloma 24.54 10.55 25 718774 7670 70201975
Left atrial enlargement 24.49 10.55 41 718758 1025 70208620
Transplant rejection 24.34 10.55 98 718701 18073 70191572
Lymphoedema 24.26 10.55 195 718604 10974 70198671
Accidental death 24.26 10.55 5 718794 3903 70205742
Hepatitis B 24.07 10.55 28 718771 8086 70201559
Atrial septal defect repair 23.97 10.55 25 718774 386 70209259
Multimorbidity 23.96 10.55 43 718756 1138 70208507
Road traffic accident 23.95 10.55 230 718569 34452 70175193
Body temperature increased 23.91 10.55 273 718526 39561 70170084
Body temperature decreased 23.90 10.55 181 718618 28491 70181154
Antibiotic level above therapeutic 23.87 10.55 31 718768 612 70209033
Gastric varices 23.85 10.55 30 718769 573 70209072
Diabetic nephropathy 23.84 10.55 72 718727 2701 70206944
Anal fistula 23.82 10.55 16 718783 6034 70203611
Tachycardia 23.71 10.55 1339 717460 157207 70052438
Aphthous ulcer 23.68 10.55 73 718726 14583 70195062
Decreased appetite 23.67 10.55 3478 715321 301302 69908343
Lung transplant 23.52 10.55 96 718703 4194 70205451
Electrocardiogram ST segment abnormal 23.49 10.55 46 718753 1303 70208342
Angiotensin converting enzyme inhibitor foetopathy 23.47 10.55 10 718789 26 70209619
Dyspepsia 23.46 10.55 705 718094 88372 70121273
Gastric ulcer haemorrhage 23.24 10.55 157 718642 8361 70201284
BK virus infection 23.23 10.55 28 718771 7961 70201684
Gastric ulcer 23.23 10.55 452 718347 31338 70178307
Neuralgia 23.17 10.55 182 718617 28421 70181224
Pre-eclampsia 23.14 10.55 19 718780 6466 70203179
Blood sodium increased 23.14 10.55 98 718701 4354 70205291
Cholecystitis chronic 23.12 10.55 37 718762 9339 70200306
Mitral valve disease 23.12 10.55 74 718725 2866 70206779
Drug effective for unapproved indication 23.10 10.55 9 718790 4626 70205019
Mitral valve stenosis 23.06 10.55 42 718757 1125 70208520
Catheter placement 22.91 10.55 70 718729 2643 70207002
Subdural haemorrhage 22.80 10.55 113 718686 5368 70204277
Pregnancy with contraceptive device 22.80 10.55 3 718796 3252 70206393
Ovarian hyperstimulation syndrome 22.66 10.55 3 718796 3237 70206408
Coagulation time prolonged 22.62 10.55 61 718738 2143 70207502
Uraemic encephalopathy 22.62 10.55 29 718770 565 70209080
Catheter site haemorrhage 22.57 10.55 103 718696 4728 70204917
Diffuse large B-cell lymphoma recurrent 22.53 10.55 4 718795 3472 70206173
Sputum culture positive 22.47 10.55 80 718719 3274 70206371
Anticoagulation drug level increased 22.47 10.55 32 718767 692 70208953
Pulmonary arterial pressure abnormal 22.44 10.55 31 718768 651 70208994
Chronic left ventricular failure 22.37 10.55 34 718765 781 70208864
Catheter site discharge 22.36 10.55 62 718737 2215 70207430
Gastrointestinal angiodysplasia 22.33 10.55 38 718761 963 70208682
Walking distance test abnormal 22.30 10.55 32 718767 697 70208948
Decubitus ulcer 22.29 10.55 231 718568 13960 70195685
Heart sounds abnormal 22.22 10.55 45 718754 1307 70208338
Hepatic steatosis 22.20 10.55 227 718572 33586 70176059
Oxygen therapy 22.19 10.55 65 718734 2397 70207248
Vision blurred 22.09 10.55 764 718035 94220 70115425
Optic neuritis 22.07 10.55 35 718764 8865 70200780
Peripheral arterial occlusive disease 22.06 10.55 141 718658 7368 70202277
Graft versus host disease in skin 22.02 10.55 15 718784 5615 70204030
Adverse reaction 21.99 10.55 33 718766 8549 70201096
Systemic infection 21.96 10.55 21 718778 6636 70203009
Weight decreased 21.95 10.55 2783 716016 307705 69901940
Nodal arrhythmia 21.93 10.55 55 718744 1848 70207797
Mental status changes 21.93 10.55 814 717985 62287 70147358
Foot fracture 21.90 10.55 113 718686 19487 70190158
Right ventricular enlargement 21.85 10.55 27 718772 506 70209139
Anaphylactic shock 21.79 10.55 217 718582 32273 70177372
Viral mutation identified 21.74 10.55 5 718794 3617 70206028
Scleritis 21.74 10.55 5 718794 3617 70206028
Transplant evaluation 21.74 10.55 49 718750 1535 70208110
Graft versus host disease in gastrointestinal tract 21.73 10.55 17 718782 5927 70203718
Hypertrophic cardiomyopathy 21.72 10.55 56 718743 1914 70207731
Pulmonary hypertensive crisis 21.70 10.55 22 718777 328 70209317
Dizziness 21.69 10.55 5161 713638 458980 69750665
Colitis microscopic 21.66 10.55 161 718638 8844 70200801
Cytomegalovirus infection reactivation 21.66 10.55 22 718777 6759 70202886
Caesarean section 21.59 10.55 54 718745 11553 70198092
Cardiac cirrhosis 21.54 10.55 18 718781 206 70209439
Catheterisation cardiac 21.53 10.55 108 718691 5155 70204490
Intestinal haemorrhage 21.52 10.55 119 718680 5901 70203744
Pneumocystis jirovecii pneumonia 21.41 10.55 198 718601 29884 70179761
Status epilepticus 21.32 10.55 153 718646 24373 70185272
Hyperprolactinaemia 21.29 10.55 9 718790 4404 70205241
Drug dose omission by device 21.29 10.55 8 718791 4204 70205441
Tongue oedema 21.23 10.55 122 718677 6137 70203508
Hypochromasia 21.23 10.55 30 718769 644 70209001
Bronchial secretion retention 21.21 10.55 73 718726 2937 70206708
Right ventricular dilatation 21.19 10.55 50 718749 1615 70208030
Aortic valve stenosis 21.17 10.55 103 718696 4856 70204789
Salivary hypersecretion 21.15 10.55 64 718735 12861 70196784
JC virus infection 21.12 10.55 5 718794 3546 70206099
Drug-induced liver injury 21.10 10.55 421 718378 55692 70153953
Product substitution issue 21.10 10.55 106 718693 18407 70191238
Drug level decreased 21.03 10.55 62 718737 12562 70197083
Blood chloride decreased 21.00 10.55 144 718655 7706 70201939
Cardioversion 20.99 10.55 55 718744 1899 70207746
Hypothermia 20.97 10.55 309 718490 20285 70189360
Haemorrhagic diathesis 20.91 10.55 113 718686 5554 70204091
Erysipelas 20.88 10.55 172 718627 9752 70199893
Extrasystoles 20.77 10.55 130 718669 6744 70202901
Platelet count decreased 20.70 10.55 2086 716713 176136 70033509
Affect lability 20.64 10.55 45 718754 10101 70199544
Ventricular internal diameter abnormal 20.57 10.55 16 718783 164 70209481
Electrocardiogram T wave peaked 20.56 10.55 34 718765 841 70208804
Purging 20.52 10.55 10 718789 39 70209606
Hyperaldosteronism 20.51 10.55 23 718776 387 70209258
Tuberculin test positive 20.47 10.55 4 718795 3242 70206403
Ureteric rupture 20.43 10.55 7 718792 7 70209638
Haemoconcentration 20.42 10.55 15 718784 140 70209505
Marasmus 20.40 10.55 35 718764 893 70208752
Subarachnoid haemorrhage 20.40 10.55 294 718505 19210 70190435
Cognitive disorder 20.38 10.55 783 718016 60173 70149472
Therapeutic embolisation 20.37 10.55 25 718774 465 70209180
Renal cancer 20.33 10.55 57 718742 11739 70197906
Blood glucose increased 20.31 10.55 1256 717543 101726 70107919
Rash maculo-papular 20.30 10.55 663 718136 49882 70159763
Blood glucose decreased 20.28 10.55 351 718448 23808 70185837
Premature labour 20.27 10.55 31 718768 7969 70201676
Surgery 20.24 10.55 200 718599 29789 70179856
Hepatitis fulminant 20.22 10.55 125 718674 6456 70203189
Epilepsy 20.20 10.55 274 718525 38510 70171135
Hyperglycaemic hyperosmolar nonketotic syndrome 20.17 10.55 53 718746 1833 70207812
Faecal calprotectin increased 20.15 10.55 10 718789 4455 70205190
Ataxia 20.10 10.55 145 718654 23072 70186573
Bladder cancer 20.06 10.55 98 718701 17144 70192501
Scleroderma 20.02 10.55 102 718697 4899 70204746
Virologic failure 19.99 10.55 7 718792 3843 70205802
Rash pruritic 19.85 10.55 486 718313 62505 70147140
Mitral valve calcification 19.84 10.55 44 718755 1363 70208282
Blood pressure diastolic increased 19.82 10.55 62 718737 12329 70197316
Acidosis 19.78 10.55 277 718522 17986 70191659
Food allergy 19.77 10.55 35 718764 8489 70201156
Hallucination, auditory 19.73 10.55 107 718692 18221 70191424
Bundle branch block 19.73 10.55 45 718754 1421 70208224
Diplopia 19.72 10.55 186 718613 27961 70181684
Enuresis 19.70 10.55 3 718796 2914 70206731
Emotional distress 19.67 10.55 505 718294 36683 70172962
Seronegative arthritis 19.62 10.55 5 718794 3374 70206271
Stillbirth 19.62 10.55 7 718792 3798 70205847
Cardiovascular insufficiency 19.60 10.55 67 718732 2686 70206959
Altered state of consciousness 19.60 10.55 538 718261 39484 70170161
Pulmonary vein stenosis 19.58 10.55 15 718784 150 70209495
Penis injury 19.56 10.55 14 718785 125 70209520
Diabetic foot 19.56 10.55 74 718725 3120 70206525
Sensitivity to weather change 19.44 10.55 28 718771 7377 70202268
Heart disease congenital 19.44 10.55 27 718772 570 70209075
Anosognosia 19.41 10.55 3 718796 2882 70206763
Alcohol poisoning 19.37 10.55 10 718789 4355 70205290
Tooth abscess 19.34 10.55 79 718720 14510 70195135
Ejection fraction abnormal 19.32 10.55 50 718749 1713 70207932
Blood urea abnormal 19.31 10.55 41 718758 1232 70208413
Catheter site pruritus 19.26 10.55 57 718742 2114 70207531
Carpal tunnel syndrome 19.25 10.55 98 718701 16959 70192686
Dermatitis exfoliative generalised 19.19 10.55 121 718678 6293 70203352
Glomerular filtration rate 19.12 10.55 14 718785 130 70209515
Pickwickian syndrome 19.11 10.55 23 718776 419 70209226
Metastases to lung 19.00 10.55 94 718705 16390 70193255
Staphylococcal sepsis 18.97 10.55 214 718585 13213 70196432
Human herpesvirus 6 infection 18.93 10.55 13 718786 4846 70204799
Priapism 18.86 10.55 9 718790 4101 70205544
Delayed graft function 18.86 10.55 75 718724 3238 70206407
End stage renal disease 18.82 10.55 184 718615 10949 70198696
Cardiac operation 18.81 10.55 92 718707 4347 70205298
Bipolar disorder 18.79 10.55 30 718769 7578 70202067
Bronchopulmonary aspergillosis 18.75 10.55 130 718669 20872 70188773
Rectal prolapse 18.70 10.55 54 718745 1975 70207670
Vital capacity decreased 18.68 10.55 43 718756 1366 70208279
Ulcer haemorrhage 18.66 10.55 96 718703 4629 70205016
Continuous haemodiafiltration 18.65 10.55 53 718746 1921 70207724
Cardiopulmonary failure 18.61 10.55 120 718679 6290 70203355
Change of bowel habit 18.59 10.55 64 718735 2575 70207070
Neoplasm malignant 18.55 10.55 194 718605 28580 70181065
Cerebral infarction 18.55 10.55 569 718230 42440 70167205
Degenerative aortic valve disease 18.54 10.55 13 718786 112 70209533
Blood potassium abnormal 18.52 10.55 66 718733 2702 70206943
Interstitial lung disease 18.51 10.55 1265 717534 103420 70106225
Candida infection 18.51 10.55 242 718557 34231 70175414
Therapy non-responder 18.50 10.55 616 718183 76299 70133346
Acute motor-sensory axonal neuropathy 18.48 10.55 22 718777 396 70209249
Wheezing 18.46 10.55 773 718026 93397 70116248
Blood bicarbonate increased 18.45 10.55 38 718761 1117 70208528
Chronic sinusitis 18.45 10.55 36 718763 8415 70201230
Carbon dioxide increased 18.44 10.55 54 718745 1991 70207654
Complication of device removal 18.42 10.55 6 718793 3448 70206197
Incorrect dose administered by device 18.42 10.55 11 718788 4418 70205227
Finger deformity 18.39 10.55 21 718778 6115 70203530
Pulmonary tuberculosis 18.38 10.55 32 718767 7813 70201832
Amyloidosis 18.37 10.55 66 718733 2713 70206932
Drug level increased 18.36 10.55 492 718307 35977 70173668
Oesophageal variceal ligation 18.35 10.55 13 718786 114 70209531
Pulmonary veno-occlusive disease 18.34 10.55 45 718754 1491 70208154
Cytomegalovirus chorioretinitis 18.32 10.55 16 718783 5282 70204363
Thirst 18.29 10.55 228 718571 14421 70195224
Cytomegalovirus colitis 18.28 10.55 10 718789 4216 70205429
Intervertebral disc protrusion 18.28 10.55 135 718664 21368 70188277
Heart transplant 18.27 10.55 42 718757 1333 70208312
Nail disorder 18.24 10.55 50 718749 10374 70199271
Urine calcium decreased 18.21 10.55 8 718791 23 70209622
Dermatitis allergic 18.20 10.55 95 718704 16336 70193309
Alcohol abuse 18.18 10.55 15 718784 5092 70204553
Melanoderma 18.16 10.55 21 718778 366 70209279
Thrombocytopenic purpura 18.12 10.55 58 718741 2246 70207399
Hypokalaemic syndrome 18.12 10.55 11 718788 72 70209573
Endophthalmitis 18.11 10.55 22 718777 6233 70203412
Scrotal swelling 18.02 10.55 35 718764 985 70208660
Oedema due to renal disease 18.01 10.55 5 718794 0 70209645
Lymphorrhoea 17.99 10.55 13 718786 118 70209527
Hypertensive heart disease 17.93 10.55 83 718716 3833 70205812
Alveolar lung disease 17.88 10.55 25 718774 531 70209114
Pulmonary alveolar haemorrhage 17.84 10.55 172 718627 10197 70199448
Haemorrhagic disorder 17.83 10.55 44 718755 1463 70208182
Troponin T increased 17.82 10.55 62 718737 2508 70207137
Implantable defibrillator insertion 17.70 10.55 32 718767 852 70208793
Intestinal stenosis 17.69 10.55 6 718793 3361 70206284
Drug tolerance 17.68 10.55 30 718769 7398 70202247
Device deployment issue 17.62 10.55 4 718795 2920 70206725
Hyperglycaemia 17.61 10.55 813 717986 63859 70145786
Hypophysitis 17.60 10.55 8 718791 3750 70205895
Body temperature fluctuation 17.59 10.55 7 718792 3552 70206093
Hydrothorax 17.56 10.55 41 718758 1315 70208330
Hypochromic anaemia 17.55 10.55 61 718738 2466 70207179
Euglycaemic diabetic ketoacidosis 17.53 10.55 21 718778 5986 70203659
Injection site discolouration 17.48 10.55 28 718771 7064 70202581
Post procedural haematoma 17.47 10.55 58 718741 2290 70207355
Hypoproteinaemia 17.46 10.55 78 718721 3548 70206097
Erythromelalgia 17.45 10.55 15 718784 179 70209466
Eye infection 17.36 10.55 49 718750 10069 70199576
Lymphoproliferative disorder 17.36 10.55 17 718782 5312 70204333
Disseminated tuberculosis 17.31 10.55 10 718789 4090 70205555
Hyperthyroidism 17.26 10.55 293 718506 19798 70189847
Dysmenorrhoea 17.19 10.55 3 718796 2637 70207008
Haemorrhagic stroke 17.18 10.55 169 718630 10073 70199572
Blood pressure systolic increased 17.17 10.55 445 718354 56814 70152831
Multiple drug therapy 17.16 10.55 71 718728 3121 70206524
Meningitis aseptic 17.12 10.55 24 718775 6395 70203250
Affective disorder 17.08 10.55 31 718768 7448 70202197
Acute myeloid leukaemia 17.06 10.55 216 718583 30724 70178921
Partial seizures 17.02 10.55 36 718763 8169 70201476
Condition aggravated 16.97 10.55 3957 714842 423678 69785967
Animal scratch 16.96 10.55 37 718762 1133 70208512
Localised oedema 16.91 10.55 131 718668 7290 70202355
Brain natriuretic peptide 16.91 10.55 9 718790 44 70209601
Lacrimation increased 16.88 10.55 125 718674 19774 70189871
Pallor 16.86 10.55 539 718260 40435 70169210
Acute myeloid leukaemia recurrent 16.84 10.55 5 718794 3049 70206596
Lipodystrophy acquired 16.80 10.55 11 718788 4205 70205440
Basilar artery occlusion 16.79 10.55 15 718784 189 70209456
Rheumatoid lung 16.78 10.55 7 718792 3452 70206193
Phlebitis deep 16.76 10.55 7 718792 17 70209628
Paroxysmal arrhythmia 16.75 10.55 9 718790 45 70209600
Peritoneal dialysis 16.74 10.55 30 718769 793 70208852
Herpes simplex 16.72 10.55 58 718741 11174 70198471
Sinus arrhythmia 16.67 10.55 51 718748 1927 70207718
Duodenal ulcer 16.65 10.55 232 718567 15048 70194597
Aspartate aminotransferase increased 16.64 10.55 1499 717300 125479 70084166
Eye pruritus 16.61 10.55 84 718715 14563 70195082
Personality disorder 16.61 10.55 19 718780 5529 70204116
Haemothorax 16.60 10.55 98 718701 4979 70204666
Acute lymphocytic leukaemia 16.59 10.55 19 718780 5526 70204119
Premature delivery 16.59 10.55 137 718662 21167 70188478
Fracture 16.58 10.55 126 718673 19818 70189827
Dizziness postural 16.54 10.55 168 718631 10100 70199545
Hyperbilirubinaemia 16.53 10.55 321 718478 22247 70187398
Abdominal wall haemorrhage 16.50 10.55 26 718773 617 70209028
Nephropathy 16.49 10.55 149 718650 8676 70200969
Linear IgA disease 16.49 10.55 66 718733 2858 70206787
Tremor 16.47 10.55 1355 717444 154269 70055376
Renal cyst haemorrhage 16.47 10.55 26 718773 618 70209027
Renal artery thrombosis 16.43 10.55 22 718777 448 70209197
Erectile dysfunction 16.42 10.55 76 718723 13486 70196159
Blood creatine abnormal 16.34 10.55 13 718786 138 70209507
Skin toxicity 16.29 10.55 30 718769 7168 70202477
Petechiae 16.25 10.55 279 718520 18893 70190752
Cardiac rehabilitation therapy 16.21 10.55 6 718793 9 70209636
Foetal exposure during pregnancy 16.19 10.55 20 718779 5625 70204020
Adenovirus infection 16.18 10.55 34 718765 7734 70201911
Cardiac hypertrophy 16.15 10.55 43 718756 1499 70208146
Sinus arrest 16.12 10.55 70 718729 3145 70206500
Infected skin ulcer 16.09 10.55 68 718731 3018 70206627
Gastrointestinal toxicity 16.06 10.55 25 718774 6380 70203265
Ventricular hypokinesia 16.04 10.55 140 718659 8072 70201573
Eye disorder 16.03 10.55 134 718665 20651 70188994
Disseminated intravascular coagulation 15.99 10.55 450 718349 33148 70176497
Cystic fibrosis 15.96 10.55 12 718787 4269 70205376
Wound secretion 15.96 10.55 104 718695 5471 70204174
Hepatic hydrothorax 15.94 10.55 10 718789 70 70209575
Haemarthrosis 15.90 10.55 102 718697 5337 70204308
Portal hypertensive gastropathy 15.89 10.55 38 718761 1238 70208407
Cardioactive drug level above therapeutic 15.86 10.55 16 718783 237 70209408
Haemorrhoidal haemorrhage 15.86 10.55 110 718689 5909 70203736
Exostosis 15.86 10.55 83 718716 14262 70195383
Catheter site erythema 15.85 10.55 95 718704 4853 70204792
Ketoacidosis 15.84 10.55 31 718768 7238 70202407
Nocturnal dyspnoea 15.82 10.55 40 718759 1351 70208294
Catatonia 15.79 10.55 37 718762 8096 70201549
SARS-CoV-2 test positive 15.78 10.55 41 718758 8660 70200985
Thrombocytopenia 15.73 10.55 2704 716095 236406 69973239
Skin weeping 15.71 10.55 28 718771 737 70208908
Immune system disorder 15.70 10.55 49 718750 9752 70199893
Tunnel vision 15.70 10.55 37 718762 1194 70208451
Latent tuberculosis 15.66 10.55 6 718793 3115 70206530
Lethargy 15.63 10.55 922 717877 74328 70135317
Aortic valve disease 15.60 10.55 45 718754 1645 70208000
Bleeding varicose vein 15.59 10.55 23 718776 514 70209131
Electrocardiogram repolarisation abnormality 15.58 10.55 49 718750 1880 70207765
Bone density abnormal 15.56 10.55 5 718794 2898 70206747
Hypoperfusion 15.47 10.55 58 718741 2435 70207210
Anosmia 15.42 10.55 16 718783 4867 70204778
Onychomycosis 15.41 10.55 29 718770 6872 70202773
Oxygen consumption decreased 15.39 10.55 20 718779 395 70209250
Cystitis 15.39 10.55 360 718439 46581 70163064
Viral infection 15.36 10.55 285 718514 38106 70171539
Tenderness 15.36 10.55 139 718660 21071 70188574
Bone cyst 15.32 10.55 5 718794 2869 70206776
Tetany 15.30 10.55 54 718745 2200 70207445
Fine motor skill dysfunction 15.27 10.55 17 718782 5007 70204638
Blood pressure systolic abnormal 15.24 10.55 73 718726 12836 70196809
Aortic dilatation 15.23 10.55 44 718755 1610 70208035
Cystitis haemorrhagic 15.20 10.55 41 718758 8552 70201093
Volume blood decreased 15.16 10.55 17 718782 286 70209359
Posterior reversible encephalopathy syndrome 15.13 10.55 166 718633 24236 70185409
Gastrointestinal arteriovenous malformation 15.13 10.55 31 718768 908 70208737
Presbyacusis 15.13 10.55 4 718795 2633 70207012
Left ventricle outflow tract obstruction 15.12 10.55 18 718781 324 70209321
Product preparation error 15.09 10.55 14 718785 4488 70205157
Injection site inflammation 15.07 10.55 8 718791 3430 70206215
Coordination abnormal 15.07 10.55 98 718701 15968 70193677
Toxic anterior segment syndrome 15.07 10.55 4 718795 2626 70207019
Intraductal papillary mucinous neoplasm 15.01 10.55 28 718771 764 70208881
Mobility decreased 15.01 10.55 872 717927 102127 70107518
Cyst 14.97 10.55 72 718727 12647 70196998
Lupus pneumonitis 14.96 10.55 10 718789 79 70209566
Right ventricular systolic pressure decreased 14.96 10.55 10 718789 79 70209566
Muscle rigidity 14.95 10.55 119 718680 18531 70191114
Gastritis haemorrhagic 14.89 10.55 57 718742 2417 70207228
Neurologic neglect syndrome 14.88 10.55 3 718796 2378 70207267
Cardiac ablation 14.86 10.55 50 718749 1988 70207657
Conjunctivitis 14.84 10.55 152 718647 22484 70187161
Skin turgor decreased 14.84 10.55 26 718773 675 70208970
Venous pressure increased 14.83 10.55 7 718792 25 70209620
Inability to afford medication 14.82 10.55 50 718749 1991 70207654
Infection reactivation 14.80 10.55 3 718796 2370 70207275
Diverticulum intestinal haemorrhagic 14.79 10.55 72 718727 3395 70206250
Menstrual disorder 14.78 10.55 9 718790 3577 70206068
Blood creatine phosphokinase increased 14.76 10.55 761 718038 60502 70149143
Gastric varices haemorrhage 14.74 10.55 18 718781 333 70209312
Supraventricular tachycardia 14.66 10.55 281 718518 19429 70190216
Device pacing issue 14.66 10.55 10 718789 82 70209563
Myxoedema coma 14.65 10.55 26 718773 682 70208963
Internal haemorrhage 14.65 10.55 136 718663 7980 70201665
Embolic stroke 14.62 10.55 125 718674 7164 70202481
Peripheral sensory neuropathy 14.58 10.55 68 718731 12042 70197603
Attention deficit hyperactivity disorder 14.56 10.55 6 718793 2981 70206664
Narrow anterior chamber angle 14.54 10.55 13 718786 164 70209481
Cardiac tamponade 14.51 10.55 142 718657 8453 70201192
Drug specific antibody 14.50 10.55 3 718796 2336 70207309
Glomerulonephritis acute 14.50 10.55 14 718785 196 70209449
General physical health deterioration 14.49 10.55 2134 716665 233897 69975748
Euphoric mood 14.48 10.55 30 718769 6859 70202786
Pulmonary artery dilatation 14.48 10.55 20 718779 420 70209225
Polyarthritis 14.41 10.55 58 718741 10698 70198947
Stroke volume decreased 14.41 10.55 4 718795 0 70209645
Visual field defect 14.38 10.55 41 718758 8397 70201248
Deformity 14.37 10.55 40 718759 8257 70201388
Sickle cell anaemia with crisis 14.36 10.55 24 718775 5954 70203691
Sleep disorder due to a general medical condition 14.35 10.55 56 718743 10420 70199225
Peripheral vascular disorder 14.34 10.55 129 718670 7503 70202142
Hypermagnesaemia 14.33 10.55 35 718764 1156 70208489
Impulsive behaviour 14.31 10.55 5 718794 2749 70206896
Encephalitis 14.25 10.55 80 718719 13505 70196140
Coma hepatic 14.25 10.55 32 718767 1000 70208645
Agitation 14.25 10.55 787 718012 92588 70117057
Transferrin saturation decreased 14.23 10.55 30 718769 897 70208748
Diabetic metabolic decompensation 14.20 10.55 65 718734 2987 70206658
Right atrial hypertrophy 14.17 10.55 24 718775 606 70209039
Tic 14.14 10.55 5 718794 2728 70206917
Contusion 14.13 10.55 1111 717688 126925 70082720
Nasal mucosal erosion 14.12 10.55 9 718790 65 70209580
Stasis dermatitis 14.07 10.55 37 718762 1280 70208365
Red blood cell count decreased 14.04 10.55 655 718144 51506 70158139
Hepatorenal failure 14.03 10.55 35 718764 1172 70208473
Hypoprothrombinaemia 14.00 10.55 26 718773 707 70208938
Dependence on oxygen therapy 13.99 10.55 20 718779 434 70209211
Cirrhosis alcoholic 13.96 10.55 31 718768 961 70208684
Cardiac failure high output 13.96 10.55 16 718783 276 70209369
Maternal exposure during breast feeding 13.93 10.55 3 718796 2271 70207374
Social avoidant behaviour 13.88 10.55 16 718783 4640 70205005
Rectal ulcer haemorrhage 13.87 10.55 15 718784 242 70209403
Nocardiosis 13.86 10.55 19 718780 5110 70204535
Acute graft versus host disease in intestine 13.84 10.55 11 718788 3805 70205840
Abnormal loss of weight 13.83 10.55 130 718669 7654 70201991
Lymphocyte stimulation test positive 13.82 10.55 33 718766 1074 70208571
Normocytic anaemia 13.82 10.55 73 718726 3557 70206088
Loss of employment 13.80 10.55 3 718796 2256 70207389
Heart valve incompetence 13.79 10.55 63 718736 2893 70206752
Fistula 13.76 10.55 60 718739 10821 70198824
Papilloedema 13.75 10.55 24 718775 5854 70203791
Aortic aneurysm 13.74 10.55 131 718668 7742 70201903
Respiratory acidosis 13.70 10.55 162 718637 10119 70199526
Sensory disturbance 13.68 10.55 83 718716 13749 70195896
Ear pruritus 13.67 10.55 7 718792 3063 70206582
Drug abuser 13.67 10.55 24 718775 5840 70203805
Osteopenia 13.64 10.55 106 718693 16591 70193054
Vaginal haemorrhage 13.62 10.55 136 718663 20216 70189429
Tooth disorder 13.62 10.55 166 718633 23772 70185873
Metastases to lymph nodes 13.56 10.55 48 718751 9190 70200455
Psychomotor hyperactivity 13.55 10.55 96 718703 15337 70194308
Cardiac death 13.55 10.55 39 718760 1424 70208221
Hyperammonaemic encephalopathy 13.54 10.55 15 718784 4428 70205217
Gastrointestinal inflammation 13.53 10.55 30 718769 6693 70202952
Oesophageal carcinoma 13.52 10.55 49 718750 9317 70200328
Atrioventricular block second degree 13.48 10.55 116 718683 6662 70202983
Postpericardiotomy syndrome 13.48 10.55 8 718791 50 70209595
Strangury 13.47 10.55 13 718786 182 70209463
Kounis syndrome 13.46 10.55 9 718790 3402 70206243
Skin lesion 13.44 10.55 292 718507 38168 70171477
Blood lactate dehydrogenase increased 13.40 10.55 458 718341 34669 70174976
Pulmonary arterial wedge pressure increased 13.36 10.55 20 718779 453 70209192
Diabetic hyperosmolar coma 13.36 10.55 26 718773 733 70208912
Pain in jaw 13.31 10.55 544 718255 42125 70167520
Brain abscess 13.28 10.55 16 718783 4550 70205095
Cytomegalovirus viraemia 13.26 10.55 67 718732 11618 70198027
Bilirubin conjugated increased 13.25 10.55 94 718705 5087 70204558
Type I hypersensitivity 13.24 10.55 11 718788 3721 70205924
Cardiac ventricular disorder 13.23 10.55 17 718782 332 70209313
Anal fissure 13.22 10.55 27 718772 6206 70203439
Premature rupture of membranes 13.21 10.55 12 718787 3886 70205759
Urinary retention 13.19 10.55 655 718144 51865 70157780
Large intestinal polypectomy 13.17 10.55 15 718784 257 70209388
Periorbital haematoma 13.15 10.55 29 718770 895 70208750
Tinnitus 13.13 10.55 273 718526 35903 70173742
Foot operation 13.12 10.55 18 718781 4839 70204806
Accidental exposure to product by child 13.10 10.55 6 718793 2800 70206845
Arteriovenous malformation 13.10 10.55 42 718757 1628 70208017
Femoral artery aneurysm 13.08 10.55 13 718786 189 70209456
Drug level below therapeutic 13.02 10.55 45 718754 8678 70200967
Pancreatitis 13.01 10.55 511 718288 62157 70147488
Coronary artery occlusion 12.99 10.55 211 718588 14134 70195511
Humerus fracture 12.98 10.55 136 718663 8242 70201403
Thyroid cancer 12.98 10.55 20 718779 5125 70204520
Metastases to central nervous system 12.96 10.55 94 718705 14940 70194705
Blood zinc decreased 12.95 10.55 5 718794 9 70209636
Major depression 12.95 10.55 44 718755 8530 70201115
Blood pressure inadequately controlled 12.90 10.55 99 718700 5493 70204152
Thermohypoaesthesia 12.89 10.55 10 718789 102 70209543
Cardiac resynchronisation therapy 12.87 10.55 7 718792 36 70209609
Cardiothoracic ratio increased 12.86 10.55 8 718791 55 70209590
Haemorrhagic arteriovenous malformation 12.86 10.55 22 718777 560 70209085
PO2 abnormal 12.80 10.55 6 718793 21 70209624
Normal newborn 12.77 10.55 28 718771 6272 70203373
Craniocerebral injury 12.75 10.55 85 718714 4506 70205139
Pulmonary haemorrhage 12.71 10.55 202 718597 13471 70196174
Right ventricular systolic pressure increased 12.71 10.55 29 718770 916 70208729
Weight increased 12.67 10.55 2211 716588 240120 69969525
CD4 lymphocytes decreased 12.64 10.55 5 718794 2546 70207099
Hypogammaglobulinaemia 12.62 10.55 67 718732 11471 70198174
Diabetes with hyperosmolarity 12.62 10.55 5 718794 10 70209635
Tachycardia induced cardiomyopathy 12.61 10.55 11 718788 134 70209511
Ventricular dyskinesia 12.61 10.55 18 718781 390 70209255
Drug monitoring procedure not performed 12.61 10.55 28 718771 868 70208777
Mucous stools 12.61 10.55 13 718786 3966 70205679
Tooth fracture 12.60 10.55 60 718739 10567 70199078
Bronchitis 12.57 10.55 1365 717434 115878 70093767
Bifascicular block 12.55 10.55 17 718782 350 70209295
Tubulointerstitial nephritis 12.55 10.55 431 718368 32645 70177000
Chest tube insertion 12.48 10.55 11 718788 136 70209509
Base excess decreased 12.48 10.55 17 718782 352 70209293
Vertebrobasilar insufficiency 12.45 10.55 13 718786 201 70209444
Hereditary angioedema 12.44 10.55 20 718779 5039 70204606
Sacroiliitis 12.43 10.55 9 718790 3264 70206381
Base excess increased 12.43 10.55 9 718790 82 70209563
Renal atrophy 12.41 10.55 42 718757 1675 70207970
Facial paresis 12.41 10.55 20 718779 5033 70204612
Gastrointestinal pain 12.40 10.55 43 718756 8284 70201361
Peritonitis 12.34 10.55 350 718449 25809 70183836
Prothrombin level decreased 12.34 10.55 39 718760 1500 70208145
Hepatic cancer stage IV 12.34 10.55 3 718796 2089 70207556
Ectopic gastric mucosa 12.31 10.55 5 718794 11 70209634
Lyme disease 12.26 10.55 7 718792 2882 70206763
Incision site pain 12.26 10.55 58 718741 2703 70206942
Haemorrhoids 12.25 10.55 343 718456 25245 70184400
Resting tremor 12.24 10.55 37 718762 1389 70208256
Peripheral embolism 12.23 10.55 44 718755 1810 70207835
Reversible airways obstruction 12.23 10.55 40 718759 1567 70208078
Pericardial fibrosis 12.23 10.55 11 718788 140 70209505
Cardiac asthma 12.22 10.55 15 718784 279 70209366
Cerebral artery embolism 12.20 10.55 41 718758 1629 70208016
Cholangiostomy 12.20 10.55 4 718795 3 70209642
Hepatitis E 12.16 10.55 6 718793 2682 70206963
Waist circumference increased 12.16 10.55 38 718761 1453 70208192
Coma uraemic 12.15 10.55 7 718792 41 70209604
Suicidal behaviour 12.14 10.55 8 718791 3048 70206597
Sight disability 12.14 10.55 10 718789 112 70209533
Catheter removal 12.14 10.55 22 718777 587 70209058
Inguinal hernia 12.13 10.55 101 718698 5744 70203901
Vitamin B1 decreased 12.13 10.55 17 718782 362 70209283
Splenic injury 12.11 10.55 14 718785 244 70209401
Liver function test abnormal 12.09 10.55 746 718053 60400 70149245
Zinc deficiency 12.09 10.55 8 718791 62 70209583
Cystostomy 12.09 10.55 8 718791 62 70209583
Acid base balance abnormal 12.09 10.55 16 718783 322 70209323
Infective exacerbation of chronic obstructive airways disease 12.08 10.55 54 718745 2457 70207188
Blood aldosterone increased 12.05 10.55 13 718786 209 70209436
Pituitary tumour benign 12.05 10.55 5 718794 2474 70207171
Pulmonary interstitial emphysema syndrome 12.05 10.55 19 718780 451 70209194
Arthrodesis 12.03 10.55 4 718795 2269 70207376
Deafness bilateral 12.02 10.55 46 718753 1950 70207695
Urine potassium increased 12.01 10.55 5 718794 12 70209633
Cystatin C increased 12.01 10.55 5 718794 12 70209633
Intraventricular haemorrhage 11.94 10.55 81 718718 4320 70205325
Prothrombin time abnormal 11.93 10.55 28 718771 901 70208744
Urethral haemorrhage 11.92 10.55 17 718782 368 70209277
Abnormal dreams 11.92 10.55 61 718738 10542 70199103
Hidradenitis 11.89 10.55 8 718791 3014 70206631
Hostility 11.88 10.55 4 718795 2251 70207394
Diverticulum 11.87 10.55 200 718599 13493 70196152
Injection site nodule 11.87 10.55 10 718789 3360 70206285
Tracheostomy 11.86 10.55 33 718766 1181 70208464
Injection site extravasation 11.82 10.55 47 718752 8699 70200946
Cerebral venous sinus thrombosis 11.81 10.55 3 718796 2028 70207617
Somatic symptom disorder 11.80 10.55 3 718796 2027 70207618
Colorectal cancer 11.78 10.55 45 718754 8425 70201220
Hyperphosphataemia 11.78 10.55 79 718720 4197 70205448
Tongue dry 11.76 10.55 31 718768 1074 70208571
Urine osmolarity decreased 11.75 10.55 9 718790 90 70209555
Glomerulonephritis membranous 11.75 10.55 39 718760 1540 70208105
Diverticulum intestinal 11.75 10.55 129 718670 7912 70201733
Aortic valve calcification 11.73 10.55 24 718775 702 70208943
Peritoneal cloudy effluent 11.72 10.55 14 718785 253 70209392
Cytokine release syndrome 11.70 10.55 193 718606 26274 70183371
Prescription drug used without a prescription 11.70 10.55 8 718791 2989 70206656
Dysphagia 11.70 10.55 984 717815 111850 70097795
Hypertensive cardiomyopathy 11.67 10.55 15 718784 293 70209352
Enteritis 11.67 10.55 79 718720 12752 70196893
Spinal fusion surgery 11.63 10.55 14 718785 3983 70205662
Renal hypertrophy 11.63 10.55 7 718792 45 70209600
Bleeding time prolonged 11.63 10.55 33 718766 1195 70208450
Portopulmonary hypertension 11.62 10.55 12 718787 183 70209462
Iridocyclitis 11.62 10.55 10 718789 3325 70206320
Penile haemorrhage 11.61 10.55 20 718779 512 70209133
Lymphocyte count decreased 11.61 10.55 344 718455 43195 70166450
Visual acuity reduced 11.60 10.55 206 718593 27724 70181921
Brain compression 11.58 10.55 20 718779 513 70209132
Autoimmune disorder 11.58 10.55 47 718752 8649 70200996
Anticholinergic syndrome 11.57 10.55 8 718791 2972 70206673
Ventricular failure 11.56 10.55 20 718779 514 70209131
Dysgeusia 11.54 10.55 398 718401 49104 70160541
Nephropathy toxic 11.49 10.55 257 718542 18257 70191388
Adjustment disorder 11.48 10.55 9 718790 3135 70206510
Transplant dysfunction 11.46 10.55 34 718765 6875 70202770
Cutaneous vasculitis 11.45 10.55 118 718681 7120 70202525
Vena cava injury 11.44 10.55 15 718784 299 70209346
BRASH syndrome 11.43 10.55 22 718777 615 70209030
Metastases to meninges 11.43 10.55 9 718790 3127 70206518
Brain scan abnormal 11.42 10.55 32 718767 1150 70208495
Extradural haematoma 11.42 10.55 56 718743 2649 70206996
Traumatic haematoma 11.39 10.55 45 718754 1937 70207708
Lymphadenitis 11.38 10.55 15 718784 4102 70205543
Facial bones fracture 11.37 10.55 82 718717 4462 70205183
QRS axis abnormal 11.35 10.55 43 718756 1814 70207831
Acquired haemophilia 11.35 10.55 43 718756 1814 70207831
Epicondylitis 11.33 10.55 3 718796 1973 70207672
Platelet transfusion 11.30 10.55 47 718752 2071 70207574
Angioplasty 11.27 10.55 42 718757 1758 70207887
Skin necrosis 11.26 10.55 108 718691 16183 70193462
Diaphragmatic paralysis 11.25 10.55 30 718769 1047 70208598
Tendon pain 11.24 10.55 23 718776 5283 70204362
ECG signs of myocardial ischaemia 11.23 10.55 16 718783 346 70209299
Endometriosis male 11.23 10.55 5 718794 15 70209630
Blood lactic acid decreased 11.23 10.55 11 718788 157 70209488
Urine output increased 11.22 10.55 44 718755 1887 70207758
Anaemia of chronic disease 11.22 10.55 51 718748 2337 70207308
Nephrogenic systemic fibrosis 11.22 10.55 102 718697 5950 70203695
Lip erosion 11.22 10.55 35 718764 1337 70208308
Agonal rhythm 11.22 10.55 8 718791 71 70209574
Cell death 11.21 10.55 77 718722 4123 70205522
Ear congestion 11.16 10.55 50 718749 2277 70207368
Vaginal discharge 11.14 10.55 18 718781 4525 70205120
Intestinal pseudo-obstruction 11.13 10.55 50 718749 2280 70207365
Mucosal dryness 11.11 10.55 63 718736 3153 70206492
Vaginal infection 11.08 10.55 23 718776 5255 70204390
Calcification metastatic 11.07 10.55 10 718789 128 70209517
Cardio-respiratory distress 11.06 10.55 14 718785 269 70209376
Urine chloride decreased 11.06 10.55 9 718790 99 70209546
Breast cancer metastatic 11.05 10.55 59 718740 10087 70199558
Sneezing 11.04 10.55 114 718685 16837 70192808
Stevens-Johnson syndrome 11.02 10.55 457 718342 35450 70174195
Focal dyscognitive seizures 11.01 10.55 11 718788 3406 70206239
Skin papilloma 10.98 10.55 24 718775 5382 70204263
Spinal pain 10.98 10.55 88 718711 13682 70195963
Renal embolism 10.95 10.55 11 718788 162 70209483
Shoshin beriberi 10.95 10.55 8 718791 74 70209571
Creatinine urine decreased 10.92 10.55 13 718786 234 70209411
Urine odour abnormal 10.92 10.55 96 718703 5547 70204098
Fanconi syndrome 10.92 10.55 7 718792 2706 70206939
Endometriosis 10.92 10.55 10 718789 3226 70206419
Embedded device 10.90 10.55 8 718791 2881 70206764
Cheyne-Stokes respiration 10.88 10.55 19 718780 492 70209153
Genital haemorrhage 10.86 10.55 27 718772 5788 70203857
Puncture site haematoma 10.85 10.55 11 718788 164 70209481
International normalised ratio 10.84 10.55 9 718790 102 70209543
Crystalluria 10.84 10.55 26 718773 849 70208796
Right atrial pressure increased 10.83 10.55 14 718785 275 70209370
Portal hypertension 10.83 10.55 107 718692 6385 70203260
Dyskinesia 10.83 10.55 325 718474 40749 70168896
Bradyphrenia 10.83 10.55 151 718648 9795 70199850
Heart valve replacement 10.81 10.55 24 718775 744 70208901
White blood cell count increased 10.81 10.55 832 717967 68741 70140904
NYHA classification 10.81 10.55 3 718796 0 70209645
Blood creatine 10.81 10.55 3 718796 0 70209645
Keratitis viral 10.81 10.55 3 718796 0 70209645
Yellow nail syndrome 10.81 10.55 3 718796 0 70209645
Urine chloride increased 10.81 10.55 3 718796 0 70209645
Urine protein/creatinine ratio decreased 10.81 10.55 3 718796 0 70209645
Tongue amyloidosis 10.81 10.55 3 718796 0 70209645
Melanocytic naevus 10.80 10.55 17 718782 4319 70205326
Renal ischaemia 10.80 10.55 30 718769 1073 70208572
Tension 10.78 10.55 15 718784 4009 70205636
Obsessive-compulsive disorder 10.77 10.55 24 718775 5346 70204299
Pericarditis constrictive 10.77 10.55 21 718778 593 70209052
Osteosclerosis 10.76 10.55 13 718786 3692 70205953
Catheter site rash 10.75 10.55 28 718771 963 70208682
Galactorrhoea 10.75 10.55 11 718788 3367 70206278
Hyperlactacidaemia 10.72 10.55 88 718711 4984 70204661
Wheelchair user 10.71 10.55 23 718776 5191 70204454
Stress 10.71 10.55 571 718228 67395 70142250
Cytopenia 10.68 10.55 118 718681 17205 70192440
Gastroenteritis norovirus 10.68 10.55 8 718791 2851 70206794
Product prescribing error 10.67 10.55 490 718309 38462 70171183
Rash morbilliform 10.66 10.55 93 718706 5362 70204283
Movement disorder 10.65 10.55 176 718623 23953 70185692
Psychogenic seizure 10.64 10.55 3 718796 1893 70207752
SARS-CoV-2 antibody test positive 10.64 10.55 16 718783 364 70209281
Diagnostic procedure 10.59 10.55 11 718788 169 70209476
Pulse pressure decreased 10.59 10.55 17 718782 410 70209235
Fear of eating 10.56 10.55 17 718782 411 70209234
Thyroxine free decreased 10.56 10.55 28 718771 974 70208671

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03CA01 CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Sulfonamides, plain
ATC C03CB01 CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Sulfonamides and potassium in combination
ATC C03EB01 CARDIOVASCULAR SYSTEM
DIURETICS
DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
High-ceiling diuretics and potassium-sparing agents
FDA PE N0000175366 Increased Diuresis at Loop of Henle
FDA EPC N0000175590 Loop Diuretic
MeSH PA D004232 Diuretics
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D045283 Natriuretic Agents
MeSH PA D049994 Sodium Potassium Chloride Symporter Inhibitors
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:77608 loop diuretics
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Acute pulmonary edema indication 40541001
Decompensated cardiac failure indication 195111005
Edema indication 267038008
Pulmonary Edema due to Chronic Heart Failure indication
Edema due to Hepatic Cirrhosis indication
Peripheral Edema due to Chronic Heart Failure indication
Hypercalcemia off-label use 66931009 DOID:12678
Prevention of Oliguria off-label use
Metabolic alkalosis contraindication 1388004
Anuria contraindication 2472002 DOID:2983
Hypocalcemia contraindication 5291005
Hypochloremia contraindication 10399008
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Diabetes mellitus contraindication 73211009 DOID:9351
Pancreatitis contraindication 75694006 DOID:4989
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Hearing disorder contraindication 128540005
Hypomagnesemia contraindication 190855004
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Azotemia contraindication 445009001




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Edema (pulmonary congestion, ascites) associated with cardiac insufficiency Indication
Cats Acute noninflammatory tissue edema Indication
Cattle Physiological parturient edema of the mammary gland and associated structures Indication
Dogs Edema (pulmonary congestion, ascites) associated with cardiac insufficiency Indication
Dogs Acute noninflammatory tissue edema Indication
Horses Edema (pulmonary congestion, ascites) associated with cardiac insufficiency Indication
Horses Acute noninflammatory tissue edema Indication

🐶 Veterinary products

ProductApplicantIngredients
Salix Injection 5% Intervet Inc. 1
Salix Tablets Intervet Inc. 1
Lasix Packets Intervet Inc. 1
Lasix Syrup 1% Intervet Inc. 1
Furos-A-Vet Bimeda Animal Health Limited 1
Disal Injection Boehringer lngelheim Animal Health USA Inc. 1
Disal Boehringer lngelheim Animal Health USA Inc. 1
Disal Boehringer lngelheim Animal Health USA Inc. 1
Furosemide Injection 5% Elanco US Inc. 1
Furosemide Syrup 1% First Priority Inc. 1
Furosemide Syrup 1% Cronus Pharma Specialities India Private Limited 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.69 acidic
pKa2 10.59 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
80MG/10ML (8MG/ML) FUROSCIX SCPHARMACEUTICALS N209988 Oct. 7, 2022 RX SOLUTION SUBCUTANEOUS 11433044 April 3, 2034 USE OF A LIQUID FORMULATION COMPRISING FUROSEMIDE TO TREAT CONGESTION DUE TO FLUID OVERLOAD (EDEMA) IN ADULTS WITH NYHA CLASS II/III CHRONIC HEART FAILURE
80MG/10ML (8MG/ML) FUROSCIX SCPHARMACEUTICALS N209988 Oct. 7, 2022 RX SOLUTION SUBCUTANEOUS 9884039 April 3, 2034 USE OF A LIQUID FORMULATION COMPRISING FUROSEMIDE TO TREAT CONGESTION DUE TO FLUID OVERLOAD (EDEMA) IN ADULTS WITH NYHA CLASS II/III CHRONIC HEART FAILURE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Solute carrier family 12 member 1 Transporter INHIBITOR IC50 6.20 WOMBAT-PK CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-1 Transporter WOMBAT-PK
Carbonic anhydrase 2 Enzyme Ki 7.19 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 7.21 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 6.25 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 6.38 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 6.58 CHEMBL
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 6.30 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 6.49 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 6.61 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 7.28 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme IC50 5.42 CHEMBL
Solute carrier family 12 member 2 Transporter INHIBITOR IC50 5.13 IUPHAR
G-protein coupled receptor 35 GPCR Ki 5.49 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 6.29 CHEMBL
CDGSH iron-sulfur domain-containing protein 1 Unclassified Ki 5.64 CHEMBL
Carbonic anhydrase 13 Enzyme Ki 6.26 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme IC50 5.42 CHEMBL
Holo-[acyl-carrieir-protein] synthase Enzyme IC50 4.90 CHEMBL

External reference:

IDSource
4017830 VUID
N0000146188 NUI
D00331 KEGG_DRUG
4017830 VANDF
C0016860 UMLSCUI
CHEBI:47426 CHEBI
FUN PDB_CHEM_ID
CHEMBL35 ChEMBL_ID
CHEMBL1788133 ChEMBL_ID
DB00695 DRUGBANK_ID
D005665 MESH_DESCRIPTOR_UI
3440 PUBCHEM_CID
4839 IUPHAR_LIGAND_ID
1584 INN_ID
7LXU5N7ZO5 UNII
4603 RXNORM
3962 MMSL
4769 MMSL
d00070 MMSL
002307 NDDF
387475002 SNOMEDCT_US
81609008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-3294 SOLUTION 10 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-3294 SOLUTION 10 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-3298 SOLUTION 40 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-3298 SOLUTION 40 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4297 TABLET 20 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4297 TABLET 20 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4299 TABLET 40 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4299 TABLET 40 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4301 TABLET 80 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4301 TABLET 80 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8297 TABLET 20 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8297 TABLET 20 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8299 TABLET 40 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8299 TABLET 40 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8301 TABLET 80 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8301 TABLET 80 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0208 TABLET 20 mg ORAL NDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0208 TABLET 20 mg ORAL NDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0216 TABLET 40 mg ORAL NDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0216 TABLET 40 mg ORAL NDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0232 TABLET 80 mg ORAL ANDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0232 TABLET 80 mg ORAL ANDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0404-9861 INJECTION, SOLUTION 10 mg INTRAMUSCULAR ANDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0404-9861 INJECTION, SOLUTION 10 mg INTRAMUSCULAR ANDA 12 sections
FUROSEMIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9862 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 12 sections
FUROSEMIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9862 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0404-9863 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 13 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0404-9863 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 13 sections
FUROSEMIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9864 INJECTION, SOLUTION 20 mg INTRAMUSCULAR ANDA 12 sections
FUROSEMIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9864 INJECTION, SOLUTION 20 mg INTRAMUSCULAR ANDA 12 sections