Scroll

furosemide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diuretics, furosemide derivatives	1258	54-31-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: frusemide furosemide furosemid	A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY. Molecular weight: 330.74 Formula: C12H11ClN2O5S CLOGP: 1.90 LIPINSKI: 0 HAC: 7 HDO: 3 TPSA: 122.63 ALOGS: -3.45 ROTB: 5 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

frusemide
furosemide
furosemid

A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.

Molecular weight: 330.74
Formula: C12H11ClN2O5S
CLOGP: 1.90
LIPINSKI: 0
HAC: 7
HDO: 3
TPSA: 122.63
ALOGS: -3.45
ROTB: 5

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
40	mg	O
40	mg	P
40	mg	O

ADMET properties:

Show entries

Search:

Property	Value	Reference
BA (Bioavailability)	71 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
EoM (Fraction excreted unchanged in urine)	66 %	Benet LZ, Broccatelli F, Oprea TI
BDDCS (Biopharmaceutical Drug Disposition Classification System)	4	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	25.92 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
t_half (Half-life)	2.50 hours	Lombardo F, Berellini G, Obach RS
CL (Clearance)	1.60 mL/min/kg	Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)	0.12 L/kg	Lombardo F, Berellini G, Obach RS
S (Water solubility)	0.07 mg/mL	Bocci G, Oprea TI, Benet LZ
fu (Fraction unbound in plasma)	0.01 %	Lombardo F, Berellini G, Obach RS

Showing 1 to 9 of 9 entries

Previous1Next

Approvals:

Date	Agency	Company	Orphan
July 1, 1966	FDA	SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	3456.16	10.57	6881	494281	256534	62731326
Cardiac failure congestive	2567.78	10.57	3399	497763	89034	62898826
Drug ineffective	1856.33	10.57	3402	497760	1041363	61946497
Cardiac failure	1635.68	10.57	2698	498464	86444	62901416
Hyperkalaemia	1543.99	10.57	2019	499143	52184	62935676
Pemphigus	1373.37	10.57	14	501148	183712	62804148
Hyponatraemia	1197.82	10.57	2695	498467	109205	62878655
Glossodynia	1161.16	10.57	61	501101	178815	62809045
Hand deformity	1153.27	10.57	21	501141	159436	62828424
Contraindicated product administered	1023.74	10.57	232	500930	217416	62770444

Showing 1 to 10 of 1,090 entries

Previous1 2 3 4 5…109Next

FDA Adverse Event Reporting System (Male)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure congestive	1934.05	11.62	3370	382693	79900	34490968
Acute kidney injury	1920.46	11.62	7532	378531	297456	34273412
Cardiac failure	1344.17	11.62	3053	383010	88195	34482673
Hyperkalaemia	1022.69	11.62	2323	383740	67066	34503802
Drug ineffective	997.04	11.62	2239	383824	454512	34116356
Drug abuse	614.57	11.62	167	385896	98929	34471939
Oedema peripheral	589.81	11.62	2753	383310	117059	34453809
Off label use	583.78	11.62	2521	383542	417003	34153865
Renal failure	534.33	11.62	2847	383216	127710	34443158
Hypotension	532.99	11.62	4225	381838	217424	34353444

Showing 1 to 10 of 767 entries

Previous1 2 3 4 5…77Next

FDA Adverse Event Reporting System (Geriatric)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	5051.68	10.43	13448	741155	505956	78483829
Cardiac failure congestive	3981.00	10.43	5769	748834	136633	78853152
Cardiac failure	2594.66	10.43	4987	749616	149855	78839930
Hyperkalaemia	2419.19	10.43	4078	750525	110320	78879465
Drug ineffective	2046.39	10.43	4511	750092	1076402	77913383
Hypotension	1372.19	10.43	7965	746638	432352	78557433
Renal failure	1335.32	10.43	4561	750042	196407	78793378
Off label use	1190.63	10.43	4498	750105	902717	78087068
International normalised ratio increased	1177.82	10.43	2527	752076	82194	78907591
Oedema peripheral	1165.73	10.43	5103	749500	247185	78742600

Showing 1 to 10 of 1,380 entries

Previous1 2 3 4 5…138Next

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Show entries

Search:

Source	Code	Description
ATC	C03CA01	CARDIOVASCULAR SYSTEM DIURETICS HIGH-CEILING DIURETICS Sulfonamides, plain
ATC	C03CB01	CARDIOVASCULAR SYSTEM DIURETICS HIGH-CEILING DIURETICS Sulfonamides and potassium in combination
ATC	C03EB01	CARDIOVASCULAR SYSTEM DIURETICS DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION High-ceiling diuretics and potassium-sparing agents
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:77608	loop diuretics
CHEBI has role	CHEBI:78298	environmental contaminants
FDA EPC	N0000175590	Loop Diuretic
FDA PE	N0000175366	Increased Diuresis at Loop of Henle
MeSH PA	D004232	Diuretics
MeSH PA	D049990	Membrane Transport Modulators

Showing 1 to 10 of 12 entries

Previous1 2Next

Drug Use | Suggest Off label Use Form| |View source of the data|

Show entries

Search:

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763
Acute pulmonary edema	indication	40541001
Decompensated cardiac failure	indication	195111005
Edema	indication	267038008
Pulmonary Edema due to Chronic Heart Failure	indication
Edema due to Hepatic Cirrhosis	indication
Peripheral Edema due to Chronic Heart Failure	indication
Hypercalcemia	off-label use	66931009	DOID:12678
Prevention of Oliguria	off-label use
Metabolic alkalosis	contraindication	1388004

Showing 1 to 10 of 30 entries

Previous1 2 3Next

🐶 Veterinary Drug Use

Show entries

Search:

Species	Use	Relation
Cats	Edema (pulmonary congestion, ascites) associated with cardiac insufficiency	Indication
Cats	Acute noninflammatory tissue edema	Indication
Cattle	Physiological parturient edema of the mammary gland and associated structures	Indication
Dogs	Edema (pulmonary congestion, ascites) associated with cardiac insufficiency	Indication
Dogs	Acute noninflammatory tissue edema	Indication
Horses	Edema (pulmonary congestion, ascites) associated with cardiac insufficiency	Indication
Horses	Acute noninflammatory tissue edema	Indication

Showing 1 to 7 of 7 entries

Previous1Next

🐶 Veterinary products

Show entries

Search:

Product	Applicant	Ingredients
Disal	Boehringer lngelheim Animal Health USA Inc.	1
Disal	Boehringer lngelheim Animal Health USA Inc.	1
Disal Injection	Boehringer lngelheim Animal Health USA Inc.	1
Furos-A-Vet	Bimeda Animal Health Limited	1
Furosemide Injection 5%	Elanco US Inc.	1
Furosemide Syrup 1%	First Priority Inc.	1
Furosemide Syrup 1%	Cronus Pharma Specialities India Private Limited	1
Lasix Packets	Intervet Inc.	1
Lasix Syrup 1%	Intervet Inc.	1
Salix Injection 5%	Intervet Inc.	1

Showing 1 to 10 of 11 entries

Previous1 2Next

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.69	acidic
pKa2	10.59	acidic

Orange Book patent data (new drug applications)

Show entries

Search:

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
80MG/10ML (8MG/ML)	FUROSCIX	SCPHARMACEUTICALS	N209988	Oct. 7, 2022	RX	SOLUTION	SUBCUTANEOUS	11433044	April 3, 2034	USE OF A LIQUID FORMULATION COMPRISING FUROSEMIDE TO TREAT CONGESTION DUE TO FLUID OVERLOAD (EDEMA) IN ADULTS WITH NYHA CLASS II/III CHRONIC HEART FAILURE
80MG/10ML (8MG/ML)	FUROSCIX	SCPHARMACEUTICALS	N209988	Oct. 7, 2022	RX	SOLUTION	SUBCUTANEOUS	9884039	April 3, 2034	USE OF A LIQUID FORMULATION COMPRISING FUROSEMIDE TO TREAT CONGESTION DUE TO FLUID OVERLOAD (EDEMA) IN ADULTS WITH NYHA CLASS II/III CHRONIC HEART FAILURE

Showing 1 to 2 of 2 entries

Previous1Next

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Show entries

Search:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Solute carrier family 12 member 1	Transporter	Q13621	S12A1_HUMAN	INHIBITOR	IC50	6.20	WOMBAT-PK	CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-1	Transporter	P05023	AT1A1_HUMAN				WOMBAT-PK
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN		Ki	7.19	CHEMBL
ATP-binding cassette sub-family G member 2	Transporter	Q9UNQ0	ABCG2_HUMAN		IC50	5.50	CHEMBL
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN		Ki	7.21	CHEMBL
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN		Ki	6.25	CHEMBL
Carbonic anhydrase 9	Enzyme	Q16790	CAH9_HUMAN		Ki	6.38	CHEMBL
Carbonic anhydrase 12	Enzyme	O43570	CAH12_HUMAN		Ki	6.58	CHEMBL
Carbonic anhydrase 5A, mitochondrial	Enzyme	P35218	CAH5A_HUMAN		Ki	6.30	CHEMBL
Carbonic anhydrase 5B, mitochondrial	Enzyme	Q9Y2D0	CAH5B_HUMAN		Ki	6.49	CHEMBL

Showing 1 to 10 of 20 entries

Previous1 2Next

External reference:

Show entries

Search:

ID	Source
FUN	PDB_CHEM_ID
002307	NDDF
1584	INN_ID
3440	PUBCHEM_CID
387475002	SNOMEDCT_US
3962	MMSL
4017830	VUID
4017830	VANDF
4603	RXNORM
4769	MMSL

Showing 1 to 10 of 22 entries

Previous1 2 3Next

Pharmaceutical products:

Show entries

Search:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-3294	SOLUTION	10 mg	ORAL	ANDA	21 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-3294	SOLUTION	10 mg	ORAL	ANDA	21 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-3294	SOLUTION	10 mg	ORAL	ANDA	21 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-3298	SOLUTION	40 mg	ORAL	ANDA	21 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-3298	SOLUTION	40 mg	ORAL	ANDA	21 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-3298	SOLUTION	40 mg	ORAL	ANDA	21 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-4297	TABLET	20 mg	ORAL	NDA	21 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-4297	TABLET	20 mg	ORAL	NDA	21 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-4297	TABLET	20 mg	ORAL	NDA	21 sections
Furosemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-4299	TABLET	40 mg	ORAL	NDA	21 sections

Showing 1 to 10 of 30 entries

Previous1 2 3Next