furosemide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diuretics, furosemide derivatives 1258 54-31-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • frusemide
  • furosemide
  • furosemid
A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
  • Molecular weight: 330.74
  • Formula: C12H11ClN2O5S
  • CLOGP: 1.90
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 122.63
  • ALOGS: -3.45
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
40 mg O
40 mg P
40 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 66 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 25.92 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 71 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.12 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.50 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 0.07 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
July 1, 1966 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 3456.16 10.57 6881 494281 256534 62731326
Cardiac failure congestive 2567.78 10.57 3399 497763 89034 62898826
Drug ineffective 1856.33 10.57 3402 497760 1041363 61946497
Cardiac failure 1635.68 10.57 2698 498464 86444 62901416
Hyperkalaemia 1543.99 10.57 2019 499143 52184 62935676
Pemphigus 1373.37 10.57 14 501148 183712 62804148
Hyponatraemia 1197.82 10.57 2695 498467 109205 62878655
Glossodynia 1161.16 10.57 61 501101 178815 62809045
Hand deformity 1153.27 10.57 21 501141 159436 62828424
Contraindicated product administered 1023.74 10.57 232 500930 217416 62770444
Hypotension 1016.92 10.57 4553 496609 268051 62719809
Systemic lupus erythematosus 1010.48 10.57 209 500953 208709 62779151
Alopecia 998.23 10.57 726 500436 336810 62651050
Arthropathy 989.63 10.57 311 500851 234481 62753379
Drug intolerance 972.62 10.57 619 500543 308042 62679818
Renal failure 962.05 10.57 2555 498607 115097 62872763
Drug interaction 902.79 10.57 3891 497271 225240 62762620
International normalised ratio increased 875.05 10.57 1423 499739 45002 62942858
Oedema peripheral 865.62 10.57 3369 497793 186142 62801718
Treatment failure 838.01 10.57 264 500898 198779 62789081
Infusion related reaction 827.36 10.57 454 500708 245067 62742793
Maternal exposure during pregnancy 820.32 10.57 355 500807 219707 62768153
Therapeutic product effect decreased 804.84 10.57 261 500901 192926 62794934
Hypokalaemia 796.10 10.57 2202 498960 101602 62886258
Off label use 771.96 10.57 2738 498424 671724 62316136
Atrial fibrillation 764.49 10.57 2339 498823 114297 62873563
Synovitis 758.65 10.57 264 500898 186654 62801206
Pericarditis 754.47 10.57 80 501082 131499 62856361
Rheumatoid arthritis 743.36 10.57 551 500611 253268 62734592
Dyspnoea 741.00 10.57 8219 492943 653094 62334766
Abdominal discomfort 733.86 10.57 872 500290 320013 62667847
Bradycardia 700.25 10.57 1688 499474 71539 62916321
Anaemia 681.09 10.57 4301 496861 289129 62698731
Discomfort 657.81 10.57 249 500913 167125 62820735
Rheumatoid factor positive 637.25 10.57 5 501157 84401 62903459
Joint swelling 622.65 10.57 1017 500145 326649 62661211
Duodenal ulcer perforation 620.32 10.57 14 501148 87195 62900665
Wound 620.05 10.57 256 500906 163007 62824853
Hypersensitivity 612.56 10.57 850 500312 291835 62696025
Fall 592.59 10.57 5193 495969 387141 62600719
Arthralgia 590.63 10.57 2406 498756 567304 62420556
Pulmonary hypertension 584.95 10.57 1051 500111 36072 62951788
Drug hypersensitivity 569.27 10.57 987 500175 309700 62678160
Pain 556.18 10.57 3500 497662 737128 62250732
Pulmonary arterial hypertension 556.01 10.57 784 500378 21793 62966067
Helicobacter infection 551.36 10.57 49 501113 92736 62895124
Hepatic enzyme increased 527.02 10.57 492 500670 201836 62786024
Musculoskeletal stiffness 517.12 10.57 419 500743 184199 62803661
Renal impairment 513.97 10.57 1701 499461 86654 62901206
Dehydration 504.44 10.57 2699 498463 170655 62817205
Melaena 502 10.57 878 500284 29487 62958373
Product use issue 500.81 10.57 602 500560 219918 62767942
Fluid retention 494.33 10.57 1303 499859 58383 62929477
Rash 481.29 10.57 2537 498625 558334 62429526
Gastrointestinal haemorrhage 475.01 10.57 1566 499596 79610 62908250
Folliculitis 462.33 10.57 22 501140 70295 62917565
Right ventricular failure 453.41 10.57 617 500545 16571 62971289
Blood creatinine increased 450.63 10.57 1622 499540 86222 62901638
Muscle injury 427.83 10.57 21 501141 65324 62922536
Myocardial infarction 417.91 10.57 1729 499433 98164 62889696
Orthostatic hypotension 413.62 10.57 895 500267 35265 62952595
Syncope 403.50 10.57 1916 499246 115469 62872391
Pulmonary oedema 386.22 10.57 1129 500033 53744 62934116
Swelling 384.82 10.57 1018 500144 274360 62713500
Lactic acidosis 374.90 10.57 891 500271 37396 62950464
Sleep disorder due to general medical condition, insomnia type 372.81 10.57 8 501154 52209 62935651
Hypoglycaemia 364.16 10.57 1173 499989 58892 62928968
Psoriatic arthropathy 363.02 10.57 134 501028 91386 62896474
Irritable bowel syndrome 358.00 10.57 103 501059 82309 62905551
Completed suicide 354.19 10.57 376 500786 145297 62842563
Blood urea increased 352.34 10.57 696 500466 25683 62962177
Oedema 325.00 10.57 1579 499583 96043 62891817
Torsade de pointes 324.83 10.57 461 500701 12890 62974970
Hypervolaemia 323.51 10.57 702 500460 27711 62960149
Rheumatic fever 318.64 10.57 4 501158 43107 62944753
Sinusitis 311.90 10.57 844 500318 225809 62762051
Fatigue 304.37 10.57 5060 496102 882968 62104892
Pleural effusion 299.83 10.57 1493 499669 91717 62896143
Intentional product use issue 295.63 10.57 344 500818 127548 62860312
Exposure during pregnancy 294.76 10.57 483 500679 155064 62832796
Therapeutic product effect incomplete 293.80 10.57 332 500830 124724 62863136
Ill-defined disorder 281.13 10.57 147 501015 81608 62906252
Ascites 277.07 10.57 828 500334 39900 62947960
Nasopharyngitis 270.60 10.57 1061 500101 253196 62734664
Gastrointestinal disorder 266.35 10.57 389 500773 130850 62857010
Impaired healing 257.89 10.57 257 500905 102285 62885575
Creatinine renal clearance decreased 257.21 10.57 462 500700 15846 62972014
Abortion spontaneous 252.53 10.57 36 501126 47159 62940701
Metabolic alkalosis 249.01 10.57 201 500961 2860 62985000
Respiratory failure 246.17 10.57 1510 499652 100348 62887512
Pneumonia 240.34 10.57 4994 496168 451773 62536087
Chronic kidney disease 235.01 10.57 841 500321 44557 62943303
Injection site reaction 231.53 10.57 86 501076 58438 62929422
Injection site erythema 231.17 10.57 190 500972 82984 62904876
Haematoma 227.55 10.57 698 500464 34122 62953738
Death 227.48 10.57 4184 496978 370197 62617663
Rhabdomyolysis 227.35 10.57 814 500348 43137 62944723
Cardioactive drug level increased 221.62 10.57 164 500998 2036 62985824
Injection site pain 217.28 10.57 435 500727 129365 62858495
Device expulsion 214.19 10.57 16 501146 34906 62952954
Cardiac failure chronic 212.79 10.57 216 500946 4202 62983658
Haemoglobin decreased 212.19 10.57 1913 499249 143572 62844288
Multiple organ dysfunction syndrome 205.63 10.57 941 500221 55811 62932049
Hip arthroplasty 204.24 10.57 61 501101 47585 62940275
Chronic obstructive pulmonary disease 200.04 10.57 1002 500160 61684 62926176
Electrocardiogram QT prolonged 199.56 10.57 965 500197 58565 62929295
Stomatitis 197.98 10.57 507 500655 138218 62849642
Cardiac failure acute 189.04 10.57 299 500863 9224 62978636
Product use in unapproved indication 188.67 10.57 750 500412 178330 62809530
Urine output decreased 180.44 10.57 323 500839 11047 62976813
Depressed level of consciousness 179.88 10.57 966 500196 61112 62926748
Hypoxia 179.81 10.57 940 500222 58852 62929008
Infection 179.26 10.57 1067 500095 228106 62759754
C-reactive protein abnormal 178.57 10.57 70 501092 46026 62941834
Dyspnoea exertional 176.53 10.57 941 500221 59361 62928499
Lower respiratory tract infection 175.66 10.57 501 500661 131806 62856054
Acute myocardial infarction 175.66 10.57 606 500556 31518 62956342
Hepatic encephalopathy 174.58 10.57 317 500845 10965 62976895
Intentional overdose 172.87 10.57 198 500964 73954 62913906
Coronary artery disease 164.34 10.57 596 500566 31781 62956079
Rectal haemorrhage 163.75 10.57 794 500368 48236 62939624
Sopor 160.69 10.57 461 500701 21703 62966157
Urticaria 160.66 10.57 717 500445 165085 62822775
Sedation complication 159.04 10.57 343 500819 13479 62974381
Liver injury 152.92 10.57 151 501011 60369 62927491
Knee arthroplasty 152.89 10.57 122 501040 54084 62933776
Blister 152.23 10.57 520 500642 129294 62858566
Headache 151.42 10.57 3825 497337 629416 62358444
Pregnancy 151.05 10.57 51 501111 36785 62951075
Sleep disorder 148.24 10.57 260 500902 81306 62906554
Suicide attempt 148.24 10.57 157 501005 60761 62927099
Injection site swelling 147.30 10.57 97 501065 47475 62940385
Blood calcium decreased 147.26 10.57 502 500660 25949 62961911
Orthopnoea 146.16 10.57 212 500950 6049 62981811
Generalised oedema 146.12 10.57 360 500802 15458 62972402
Epistaxis 144.63 10.57 1027 500135 71698 62916162
Red blood cell sedimentation rate increased 142.64 10.57 85 501077 43897 62943963
Blood potassium decreased 142.09 10.57 683 500479 41343 62946517
Transfusion 141.28 10.57 347 500815 14870 62972990
Toxic epidermal necrolysis 141.21 10.57 481 500681 24853 62963007
Acute respiratory failure 139.48 10.57 591 500571 33894 62953966
Sepsis 138.95 10.57 1832 499330 151291 62836569
Ventricular tachycardia 137.58 10.57 408 500754 19571 62968289
Anuria 135.95 10.57 304 500858 12247 62975613
Asthenia 135.85 10.57 3976 497186 379628 62608232
Shock haemorrhagic 135.66 10.57 264 500898 9631 62978229
Cardiomegaly 135.17 10.57 374 500788 17240 62970620
Cerebrovascular accident 134.47 10.57 1374 499788 106650 62881210
Injection site pruritus 134.35 10.57 96 501066 45020 62942840
Presyncope 133.91 10.57 503 500659 27282 62960578
Blood pressure decreased 133.26 10.57 925 500237 64097 62923763
Subdural haematoma 131.20 10.57 325 500837 14003 62973857
Cardiogenic shock 129.05 10.57 372 500790 17560 62970300
Cardiac disorder 128.85 10.57 763 500399 50053 62937807
Red blood cell sedimentation rate abnormal 127.44 10.57 7 501155 19775 62968085
Mitral valve incompetence 127.28 10.57 392 500770 19202 62968658
Type 2 diabetes mellitus 126.90 10.57 192 500970 63676 62924184
Hepatic failure 126.02 10.57 587 500575 35069 62952791
Hypomagnesaemia 125.28 10.57 504 500658 28233 62959627
Blood potassium increased 125.23 10.57 373 500789 17936 62969924
Oliguria 123.78 10.57 242 500920 8859 62979001
Pseudo-Bartter syndrome 122.92 10.57 39 501123 40 62987820
Hypovolaemia 121.81 10.57 264 500898 10409 62977451
Pericardial effusion 121.46 10.57 515 500647 29543 62958317
Cellulitis 121.09 10.57 1081 500081 80877 62906983
Cardiac arrest 120.91 10.57 1189 499973 91356 62896504
Hypocalcaemia 120.22 10.57 533 500629 31180 62956680
Loss of personal independence in daily activities 120.06 10.57 381 500781 96909 62890951
Adverse drug reaction 118.63 10.57 285 500877 79429 62908431
Haematemesis 115.94 10.57 512 500650 29900 62957960
Blood cholesterol increased 115.50 10.57 369 500793 93663 62894197
Balance disorder 114.39 10.57 1093 500069 83329 62904531
Paraesthesia 112.77 10.57 750 500412 156216 62831644
Injection site bruising 110.04 10.57 101 501061 41809 62946051
Hypernatraemia 109.21 10.57 207 500955 7402 62980458
Renal injury 108.33 10.57 234 500928 9205 62978655
Hyperuricaemia 107.13 10.57 169 500993 5201 62982659
Brain natriuretic peptide increased 106.70 10.57 166 500996 5047 62982813
Toxic skin eruption 105.29 10.57 280 500882 12605 62975255
Atrial flutter 105.07 10.57 236 500926 9536 62978324
N-terminal prohormone brain natriuretic peptide increased 102.89 10.57 105 501057 2056 62985804
Blood loss anaemia 101.99 10.57 222 500940 8779 62979081
Night sweats 101.63 10.57 142 501020 48672 62939188
Hypoaesthesia 99.86 10.57 849 500313 167544 62820316
Bradyarrhythmia 99.31 10.57 102 501060 2013 62985847
Nephrocalcinosis 98.92 10.57 76 501086 1002 62986858
Fibromyalgia 98.48 10.57 316 500846 80104 62907756
Migraine 97.62 10.57 451 500711 102895 62884965
Drug abuse 97.39 10.57 273 500889 72245 62915615
Acute pulmonary oedema 96.80 10.57 205 500957 7953 62979907
Hypochloraemia 96.35 10.57 98 501064 1911 62985949
Oxygen saturation decreased 95.51 10.57 1095 500067 87490 62900370
Respiratory distress 94.07 10.57 522 500640 33429 62954431
Cardiomyopathy 92.05 10.57 327 500835 17257 62970603
Blood sodium decreased 91.46 10.57 407 500755 23845 62964015
Ventricular fibrillation 91.08 10.57 252 500910 11615 62976245
Adverse event 90.97 10.57 254 500908 67305 62920555
Atrioventricular block complete 90.66 10.57 201 500961 8050 62979810
Drug tolerance decreased 89.66 10.57 15 501147 17458 62970402
Inflammation 89.50 10.57 340 500822 81933 62905927
Gout 89.47 10.57 269 500893 13002 62974858
Pruritus 89.43 10.57 2171 498991 359282 62628578
Electrolyte imbalance 89.03 10.57 354 500808 19722 62968138
Arrhythmia 88.67 10.57 560 500602 37580 62950280
Atrioventricular block 88.24 10.57 190 500972 7457 62980403
Glomerular filtration rate decreased 87.39 10.57 269 500893 13172 62974688
Ischaemic stroke 86.46 10.57 325 500837 17632 62970228
Grip strength decreased 86.06 10.57 34 501128 22253 62965607
Psoriasis 86.02 10.57 373 500789 86584 62901276
Blood bilirubin increased 85.53 10.57 544 500618 36596 62951264
Rheumatoid nodule 85.26 10.57 16 501146 17139 62970721
Joint stiffness 84.98 10.57 124 501038 41745 62946115
Rales 83.38 10.57 255 500907 12442 62975418
Lower gastrointestinal haemorrhage 79.80 10.57 186 500976 7704 62980156
Multiple sclerosis relapse 79.76 10.57 164 500998 48314 62939546
Accidental exposure to product 79.40 10.57 60 501102 27345 62960515
Prerenal failure 78.20 10.57 81 501081 1615 62986245
Foot deformity 78.15 10.57 63 501099 27790 62960070
Hypovolaemic shock 77.75 10.57 160 501002 6081 62981779
Pemphigoid 77.44 10.57 176 500986 7168 62980692
Haemoptysis 77.16 10.57 438 500724 28288 62959572
Pulmonary arterial pressure increased 77.12 10.57 117 501045 3478 62984382
Blood alkaline phosphatase increased 76.98 10.57 592 500570 42375 62945485
Haemodialysis 76.76 10.57 198 500964 8749 62979111
Iron deficiency anaemia 76.73 10.57 337 500825 19632 62968228
Live birth 75.70 10.57 55 501107 25575 62962285
Shock 75.49 10.57 376 500786 23087 62964773
Sudden death 75.41 10.57 217 500945 10232 62977628
Inappropriate schedule of product administration 75.02 10.57 496 500666 103469 62884391
Upper gastrointestinal haemorrhage 74.61 10.57 321 500841 18531 62969329
Loss of consciousness 74.58 10.57 1329 499833 116792 62871068
Haematuria 74.04 10.57 438 500724 28719 62959141
Nausea 73.98 10.57 5777 495385 848694 62139166
Cerebral haemorrhage 73.82 10.57 455 500707 30274 62957586
Lip dry 73.61 10.57 16 501146 15454 62972406
Therapeutic response decreased 73.08 10.57 245 500917 61280 62926580
Joint range of motion decreased 72.98 10.57 89 501073 32339 62955521
Tenosynovitis 72.69 10.57 11 501151 13784 62974076
Metabolic acidosis 72.06 10.57 605 500557 44464 62943396
Drug resistance 72.02 10.57 46 501116 22887 62964973
Drug ineffective for unapproved indication 72 10.57 98 501064 33965 62953895
Dialysis 71.85 10.57 213 500949 10214 62977646
Prothrombin time prolonged 71.34 10.57 201 500961 9363 62978497
Pneumonia aspiration 69.95 10.57 490 500672 34050 62953810
Suicidal ideation 69.16 10.57 256 500906 62165 62925695
Bone erosion 68.46 10.57 27 501135 17690 62970170
Renal disorder 68.08 10.57 470 500692 32504 62955356
Musculoskeletal pain 67.71 10.57 438 500724 91839 62896021
Intra-abdominal haematoma 67.17 10.57 77 501085 1728 62986132
Cognitive disorder 67.07 10.57 705 500457 55110 62932750
Left ventricular failure 66.43 10.57 142 501020 5545 62982315
COVID-19 66.24 10.57 572 500590 112531 62875329
Facet joint syndrome 65.53 10.57 9 501153 12129 62975731
Cardiac output decreased 64.98 10.57 57 501105 915 62986945
Muscle haemorrhage 64.74 10.57 101 501061 3078 62984782
Pulmonary congestion 64.70 10.57 291 500871 17127 62970733
Hepatic function abnormal 64.47 10.57 508 500654 36634 62951226
Sedation 63.13 10.57 523 500639 38286 62949574
Chest pain 62.55 10.57 2186 498976 213773 62774087
Plasma cell myeloma 62.27 10.57 491 500671 35414 62952446
Azotaemia 62.16 10.57 120 501042 4351 62983509
Congestive hepatopathy 62.06 10.57 95 501067 2847 62985013
Concomitant disease aggravated 61.71 10.57 185 500977 8927 62978933
Foetal exposure during pregnancy 61.65 10.57 98 501064 31864 62955996
Ischaemic cardiomyopathy 60.94 10.57 86 501076 2391 62985469
Congestive cardiomyopathy 60.63 10.57 144 501018 6038 62981822
Aortic stenosis 60.55 10.57 127 501035 4893 62982967
Osteoarthritis 60.47 10.57 472 500690 94871 62892989
Acne 60.13 10.57 57 501105 23236 62964624
Intentional self-injury 59.41 10.57 69 501093 25618 62962242
Abdominal wall haematoma 59.37 10.57 95 501067 2960 62984900
Oral herpes 59.27 10.57 71 501091 26003 62961857
No adverse event 59.27 10.57 151 501011 41254 62946606
Cor pulmonale 59.18 10.57 77 501085 1977 62985883
Ejection fraction decreased 58.33 10.57 338 500824 21994 62965866
Septic shock 57.82 10.57 791 500371 65838 62922022
Myopathy 57.62 10.57 207 500955 10984 62976876
Jaundice 57.50 10.57 412 500750 28839 62959021
Device difficult to use 57.41 10.57 15 501147 12781 62975079
Disability 57.35 10.57 37 501125 18310 62969550
Confusional state 56.83 10.57 2344 498818 234036 62753824
Muscle spasticity 56.65 10.57 53 501109 21741 62966119
Anaphylactic reaction 56.34 10.57 299 500863 65801 62922059
Insomnia 55.89 10.57 1283 499879 213969 62773891
Cardio-respiratory arrest 55.00 10.57 719 500443 59240 62928620
Arteriosclerosis coronary artery 54.83 10.57 168 500994 8205 62979655
Injection site rash 54.72 10.57 41 501121 18768 62969092
Condition aggravated 54.66 10.57 2606 498556 399611 62588249
Infective pulmonary exacerbation of cystic fibrosis 54.18 10.57 4 501158 8813 62979047
Tricuspid valve incompetence 54.10 10.57 244 500918 14377 62973483
Basal cell carcinoma 53.82 10.57 86 501076 27905 62959955
Coagulopathy 53.70 10.57 311 500851 20233 62967627
Injection site urticaria 53.47 10.57 22 501140 14051 62973809
Dilatation ventricular 53.06 10.57 80 501082 2365 62985495
Urinary tract discomfort 52.97 10.57 43 501119 617 62987243
Aspartate aminotransferase increased 52.88 10.57 1004 500158 89273 62898587
Injection site warmth 52.69 10.57 27 501135 15168 62972692
Renal tubular necrosis 52.31 10.57 209 500953 11669 62976191
International normalised ratio decreased 52.13 10.57 112 501050 4389 62983471
Faeces discoloured 51.55 10.57 285 500877 18224 62969636
Sinus node dysfunction 51.33 10.57 114 501048 4571 62983289
Oxygen consumption increased 51.27 10.57 102 501060 3782 62984078
Platelet count decreased 50.81 10.57 1238 499924 114884 62872976
Diabetes mellitus inadequate control 50.52 10.57 245 500917 14881 62972979
Sinus bradycardia 50.27 10.57 238 500924 14313 62973547
Catheter management 50.17 10.57 87 501075 2900 62984960
Myocardial ischaemia 50.16 10.57 218 500944 12641 62975219
Hyperglycaemia 49.91 10.57 528 500634 41339 62946521
Aortic valve incompetence 49.81 10.57 131 501031 5857 62982003
Nodal rhythm 49.69 10.57 65 501097 1678 62986182
Disorientation 49.62 10.57 503 500659 38949 62948911
Encephalopathy 49.35 10.57 494 500668 38126 62949734
Blood parathyroid hormone decreased 48.94 10.57 9 501153 9782 62978078
Tunnel vision 48.88 10.57 54 501108 1162 62986698
Subcutaneous haematoma 48.87 10.57 64 501098 1654 62986206
Ovarian cyst 48.70 10.57 33 501129 15912 62971948
Arthritis 48.49 10.57 634 500528 115287 62872573
Intestinal haemorrhage 48.37 10.57 99 501063 3748 62984112
Gestational diabetes 48.36 10.57 5 501157 8391 62979469
Drug reaction with eosinophilia and systemic symptoms 48.27 10.57 443 500719 33393 62954467
Head injury 48.26 10.57 376 500786 27020 62960840
Cardiac pacemaker insertion 48.16 10.57 103 501059 4023 62983837
Myoclonus 48.05 10.57 250 500912 15618 62972242
Maternal exposure before pregnancy 48.03 10.57 3 501159 7600 62980260
Haemorrhage 47.98 10.57 712 500450 60310 62927550
Ecchymosis 47.89 10.57 194 500968 10900 62976960
Lupus-like syndrome 47.59 10.57 31 501131 15264 62972596
Psychotic disorder 47.57 10.57 81 501081 25631 62962229
Enthesopathy 47.43 10.57 6 501156 8608 62979252
Alveolar osteitis 46.99 10.57 46 501116 855 62987005
Mental status changes 46.55 10.57 498 500664 39101 62948759
Bursitis 46.42 10.57 144 501018 36897 62950963
Microcytic anaemia 46.41 10.57 91 501071 3338 62984522
Hyponatraemic syndrome 46.33 10.57 37 501125 518 62987342
Impaired work ability 46.01 10.57 42 501120 17433 62970427
Breast cancer stage II 45.95 10.57 7 501155 8729 62979131
Gastrointestinal tract mucosal pigmentation 45.76 10.57 38 501124 564 62987296
Peripartum cardiomyopathy 45.70 10.57 23 501139 132 62987728
Polyuria 45.70 10.57 160 501002 8382 62979478
Vital capacity decreased 45.52 10.57 62 501100 1666 62986194
Cholestasis 45.40 10.57 392 500770 29042 62958818
Angina unstable 45.20 10.57 141 501021 6954 62980906
International normalised ratio abnormal 45.11 10.57 88 501074 3216 62984644
Unevaluable event 44.97 10.57 611 500551 50775 62937085
Bone density decreased 44.95 10.57 30 501132 14582 62973278
Anxiety 44.49 10.57 1342 499820 216199 62771661
Exercise tolerance decreased 44.45 10.57 119 501043 5378 62982482
Coronary arterial stent insertion 44.42 10.57 80 501082 2749 62985111
Lethargy 44.23 10.57 654 500508 55353 62932507
Bundle branch block left 43.79 10.57 139 501023 6920 62980940
Wound secretion 43.66 10.57 106 501056 4508 62983352
Progressive multifocal leukoencephalopathy 43.58 10.57 24 501138 12947 62974913
Agranulocytosis 43.20 10.57 343 500819 24791 62963069
Cerebral haematoma 43.06 10.57 92 501070 3591 62984269
Activated partial thromboplastin time prolonged 43.01 10.57 136 501026 6757 62981103
Febrile neutropenia 42.79 10.57 667 500495 117782 62870078
Acidosis 42.72 10.57 189 500973 11044 62976816
Incorrect route of product administration 42.55 10.57 96 501066 27356 62960504
Uveitis 42.50 10.57 23 501139 12530 62975330
Concomitant disease progression 42.35 10.57 67 501095 2067 62985793
Colitis ulcerative 42.30 10.57 89 501073 26002 62961858
Pyrexia 42.21 10.57 3170 497992 467308 62520552
Device issue 42.11 10.57 77 501085 23704 62964156
Petechiae 42.11 10.57 219 500943 13678 62974182
Dermatitis exfoliative 41.97 10.57 116 501046 5343 62982517
Hypoglycaemic coma 41.95 10.57 74 501088 2501 62985359
Thrombocytopenia 41.75 10.57 1522 499640 149635 62838225
Prothrombin time shortened 41.49 10.57 64 501098 1931 62985929
Tachypnoea 41.43 10.57 256 500906 17046 62970814
Hypercapnia 41.35 10.57 115 501047 5316 62982544
Acute coronary syndrome 41.29 10.57 174 500988 9952 62977908
Decreased appetite 40.93 10.57 2397 498765 248655 62739205
Blood albumin decreased 40.88 10.57 227 500935 14539 62973321
Gravitational oedema 40.55 10.57 49 501113 1165 62986695
Uterine perforation 40.49 10.57 4 501158 6959 62980901
Nephrotic syndrome 40.43 10.57 116 501046 5460 62982400
Ear infection 40.21 10.57 160 501002 38053 62949807
Dilatation atrial 40.19 10.57 63 501099 1928 62985932
Autoimmune disorder 39.87 10.57 46 501116 17131 62970729
Throat irritation 39.38 10.57 158 501004 37489 62950371
Catheter site infection 39.36 10.57 106 501056 4808 62983052
Prescribed overdose 39.20 10.57 138 501024 34015 62953845
Sputum culture positive 38.88 10.57 65 501097 2102 62985758
Maternal exposure timing unspecified 38.87 10.57 5 501157 7082 62980778
Ankylosing spondylitis 38.79 10.57 17 501145 10457 62977403
Atrioventricular block first degree 38.71 10.57 136 501026 7137 62980723
Therapeutic response shortened 38.51 10.57 23 501139 11865 62975995
Coronary artery bypass 38.49 10.57 68 501094 2301 62985559
Ventricular arrhythmia 38.45 10.57 90 501072 3738 62984122
Jugular vein distension 38.28 10.57 43 501119 943 62986917
Reversible airways obstruction 38.18 10.57 59 501103 1783 62986077
Angina pectoris 38.07 10.57 384 500778 29694 62958166
Multiple drug therapy 38.02 10.57 87 501075 3559 62984301
Heparin-induced thrombocytopenia 37.87 10.57 100 501062 4482 62983378
Dystonia 37.85 10.57 32 501130 13787 62974073
Pharyngitis 37.69 10.57 63 501099 20080 62967780
Myelosuppression 37.47 10.57 82 501080 23621 62964239
Cardiac valve disease 37.41 10.57 95 501067 4157 62983703
X-ray abnormal 37.36 10.57 9 501153 8101 62979759
Ischaemic hepatitis 37.34 10.57 63 501099 2053 62985807
Poor venous access 37.21 10.57 37 501125 14748 62973112
Fear of injection 37.09 10.57 6 501156 7158 62980702
Wrong technique in product usage process 37.05 10.57 314 500848 62026 62925834
Change of bowel habit 37.00 10.57 64 501098 2129 62985731
Altered state of consciousness 36.84 10.57 332 500830 24898 62962962
Product quality issue 36.59 10.57 152 501010 35713 62952147
Sciatica 36.57 10.57 143 501019 34181 62953679
Abdominal distension 36.56 10.57 919 500243 85696 62902164
Cyanosis 36.51 10.57 244 500918 16691 62971169
Acute generalised exanthematous pustulosis 36.51 10.57 179 500983 10920 62976940
Urinary tract infection 36.34 10.57 2490 498672 262194 62725666
Pneumonia viral 36.18 10.57 141 501021 7781 62980079
Colitis microscopic 36.18 10.57 158 501004 9181 62978679
Tendonitis 36.10 10.57 62 501100 19553 62968307
Mood swings 36.10 10.57 55 501107 18193 62969667
Animal scratch 36.03 10.57 50 501112 1368 62986492
Blood iron decreased 36.00 10.57 219 500943 14502 62973358
Ventricular dysfunction 35.82 10.57 73 501089 2755 62985105
Breast cancer 35.81 10.57 229 500933 48154 62939706
Chronic respiratory failure 35.74 10.57 59 501103 1888 62985972
Dry eye 35.51 10.57 183 500979 40578 62947282
Retroperitoneal haematoma 35.49 10.57 74 501088 2839 62985021
Prescribed underdose 35.40 10.57 118 501044 29571 62958289
Bundle branch block right 35.30 10.57 103 501059 4895 62982965
Breast cancer stage I 35.16 10.57 6 501156 6883 62980977
Oesophageal varices haemorrhage 35.15 10.57 46 501116 1188 62986672
Disease recurrence 35.10 10.57 109 501053 27921 62959939
Haematotoxicity 35.07 10.57 15 501147 9361 62978499
Abdominal pain upper 35.05 10.57 1304 499858 205140 62782720
Circulatory collapse 34.80 10.57 294 500868 21644 62966216
Ear congestion 34.69 10.57 71 501091 2688 62985172
Electrocardiogram ST segment abnormal 34.68 10.57 41 501121 952 62986908
Product dose omission issue 34.63 10.57 1504 499658 232809 62755051
Panniculitis 34.19 10.57 24 501138 11361 62976499
Hepatotoxicity 34.16 10.57 163 500999 36878 62950982
Constipation 33.90 10.57 2133 499029 222810 62765050
Disseminated intravascular coagulation 33.85 10.57 262 500900 18789 62969071
Dermatitis bullous 33.77 10.57 145 501017 8363 62979497
Device dislocation 33.60 10.57 98 501064 25607 62962253
Eosinophilia 33.51 10.57 300 500862 22456 62965404
Liver function test increased 33.51 10.57 139 501023 32672 62955188
Oropharyngeal pain 33.47 10.57 534 500628 93953 62893907
Mucosal inflammation 33.28 10.57 225 500937 46703 62941157
Haemorrhage subcutaneous 33.15 10.57 73 501089 2910 62984950
Blood glucose decreased 32.82 10.57 280 500882 20672 62967188
Scleroderma 32.47 10.57 106 501056 5356 62982504
Joint dislocation 32.30 10.57 62 501100 18738 62969122
Nodule 32.21 10.57 74 501088 20952 62966908
Liver function test abnormal 32.15 10.57 547 500615 47634 62940226
Fear 32.11 10.57 224 500938 15542 62972318
Soft tissue disorder 32.07 10.57 92 501070 4330 62983530
Inferior vena cava dilatation 31.94 10.57 15 501147 72 62987788
Staphylococcal sepsis 31.86 10.57 138 501024 7990 62979870
Complication of device insertion 31.84 10.57 10 501152 7554 62980306
Breast cancer female 31.81 10.57 36 501126 13523 62974337
Blood creatine increased 31.79 10.57 107 501055 5494 62982366
Blood uric acid increased 31.77 10.57 104 501058 5263 62982597
Troponin increased 31.72 10.57 161 501001 9960 62977900
Immune reconstitution inflammatory syndrome 31.72 10.57 5 501157 6079 62981781
Interstitial lung disease 31.42 10.57 674 500488 61234 62926626
Hepatic cirrhosis 31.41 10.57 316 500846 24418 62963442
Therapy partial responder 31.31 10.57 23 501139 10635 62977225
Venous pressure jugular increased 31.11 10.57 30 501132 547 62987313
Blepharospasm 31.09 10.57 5 501157 5991 62981869
Haemorrhoidal haemorrhage 31.01 10.57 89 501073 4190 62983670
Bradyphrenia 30.88 10.57 123 501039 6857 62981003
Blood creatinine abnormal 30.86 10.57 72 501090 2984 62984876
Depression 30.76 10.57 1253 499909 195239 62792621
Dyspepsia 30.63 10.57 595 500567 101601 62886259
Eye pain 30.62 10.57 150 501012 33704 62954156
Extrasystoles 30.55 10.57 100 501062 5060 62982800
Ventricular hypertrophy 30.47 10.57 77 501085 3359 62984501
Hypophagia 30.42 10.57 379 500783 30880 62956980
Macular degeneration 30.38 10.57 95 501067 24281 62963579
Alkalosis hypochloraemic 30.37 10.57 18 501144 149 62987711
BRASH syndrome 30.35 10.57 27 501135 442 62987418
Protein total decreased 30.30 10.57 110 501052 5867 62981993
Occult blood positive 30.23 10.57 80 501082 3590 62984270
Vascular purpura 30.16 10.57 47 501115 1431 62986429
Right-to-left cardiac shunt 30.11 10.57 21 501141 236 62987624
Catheter site erythema 30.08 10.57 88 501074 4188 62983672
Renal artery stenosis 29.99 10.57 54 501108 1855 62986005
Haemorrhage intracranial 29.94 10.57 195 500967 13224 62974636
Lymphoedema 29.91 10.57 176 500986 11516 62976344
Anticoagulation drug level above therapeutic 29.79 10.57 46 501116 1389 62986471
Amenorrhoea 29.64 10.57 21 501141 9893 62977967
Ulcer 29.62 10.57 106 501056 26001 62961859
Bronchitis 29.55 10.57 1237 499925 123698 62864162
Hypercreatininaemia 29.49 10.57 29 501133 542 62987318
Pelvic pain 29.48 10.57 38 501124 13481 62974379
Device use error 29.44 10.57 5 501157 5756 62982104
Alkalosis 29.41 10.57 24 501138 347 62987513
Haematocrit decreased 29.37 10.57 455 500707 38885 62948975
Decubitus ulcer 29.31 10.57 162 501000 10358 62977502
General physical health deterioration 29.29 10.57 1295 499867 200107 62787753
Osteoporosis 29.26 10.57 300 500862 57038 62930822
Wound complication 29.18 10.57 80 501082 3667 62984193
Hypoalbuminaemia 29.11 10.57 176 500986 11629 62976231
Abdominal cavity drainage 28.98 10.57 25 501137 392 62987468
Blood chloride decreased 28.95 10.57 103 501059 5439 62982421
Paracentesis 28.94 10.57 37 501125 933 62986927
Nephrogenic anaemia 28.81 10.57 57 501105 2105 62985755
Arteriosclerosis 28.71 10.57 156 501006 9910 62977950
Cerebral infarction 28.32 10.57 301 500861 23592 62964268
Tooth infection 28.32 10.57 62 501100 17858 62970002
Hepatocellular carcinoma 28.22 10.57 57 501105 2137 62985723
Atrial enlargement 28.22 10.57 23 501139 332 62987528
Menstruation irregular 28.19 10.57 10 501152 6994 62980866
Duodenal ulcer haemorrhage 28.13 10.57 61 501101 2406 62985454
Nephrosclerosis 28.04 10.57 38 501124 1016 62986844
Ventricular extrasystoles 28.03 10.57 173 500989 11514 62976346
C-reactive protein increased 27.90 10.57 553 500609 94154 62893706
Urine odour abnormal 27.80 10.57 112 501050 6277 62981583
Pre-eclampsia 27.76 10.57 19 501143 9114 62978746
Basilar artery occlusion 27.74 10.57 15 501147 102 62987758
Paraesthesia oral 27.73 10.57 70 501092 19186 62968674
Pancytopenia 27.73 10.57 980 500182 95953 62891907
Mitral valve stenosis 27.69 10.57 40 501122 1137 62986723
Dry mouth 27.59 10.57 440 500722 77423 62910437
Therapy non-responder 27.54 10.57 427 500735 75474 62912386
Peritonitis bacterial 27.51 10.57 93 501069 4786 62983074
Laryngitis 27.40 10.57 58 501104 16909 62970951
Visual impairment 27.38 10.57 485 500677 83961 62903899
Anhedonia 27.31 10.57 164 500998 10810 62977050
Cardiac operation 27.28 10.57 72 501090 3226 62984634
Pulmonary alveolar haemorrhage 27.22 10.57 90 501072 4578 62983282
Neck pain 27.22 10.57 384 500778 68934 62918926
Gastritis erosive 27.19 10.57 107 501055 5932 62981928
Right atrial dilatation 27.10 10.57 30 501132 647 62987213
Nephropathy toxic 27.10 10.57 147 501015 9332 62978528
Tachyarrhythmia 27.03 10.57 87 501075 4363 62983497
Metabolic encephalopathy 27.03 10.57 104 501058 5705 62982155
Pain in jaw 26.94 10.57 488 500674 43008 62944852
Low cardiac output syndrome 26.77 10.57 24 501138 397 62987463
Sinus arrest 26.72 10.57 52 501110 1897 62985963
Tubulointerstitial nephritis 26.60 10.57 257 500905 19646 62968214
Nodal arrhythmia 26.60 10.57 39 501123 1124 62986736
Bronchial secretion retention 26.56 10.57 64 501098 2709 62985151
Pregnancy with contraceptive device 26.51 10.57 3 501159 4691 62983169
Device related infection 26.48 10.57 292 500870 23100 62964760
Mixed liver injury 26.47 10.57 90 501072 4645 62983215
Blood pressure inadequately controlled 26.42 10.57 93 501069 4885 62982975
Respiratory acidosis 26.31 10.57 114 501048 6601 62981259
Diabetes mellitus 26.23 10.57 601 500561 55209 62932651
Hypoxic-ischaemic encephalopathy 26.21 10.57 84 501078 4203 62983657
Oxygen therapy 26.15 10.57 55 501107 2123 62985737
Wheezing 26.15 10.57 565 500597 95030 62892830
Schizophrenia 26.10 10.57 24 501138 9928 62977932
Gamma-glutamyltransferase increased 25.94 10.57 395 500767 33636 62954224
Cardiac murmur 25.78 10.57 200 500962 14352 62973508
Aspiration pleural cavity 25.76 10.57 33 501129 834 62987026
Walking distance test abnormal 25.72 10.57 27 501135 547 62987313
Multiple sclerosis 25.67 10.57 102 501060 24270 62963590
Haemorrhagic diathesis 25.64 10.57 85 501077 4330 62983530
Lung transplant 25.58 10.57 68 501094 3060 62984800
Asthma 25.54 10.57 789 500373 126772 62861088
Left ventricular dysfunction 25.41 10.57 172 500990 11816 62976044
Gastric haemorrhage 25.36 10.57 109 501053 6289 62981571
Central nervous system lesion 25.21 10.57 28 501134 10607 62977253
Ear pain 25.20 10.57 174 500988 35944 62951916
Dyspnoea paroxysmal nocturnal 25.15 10.57 34 501128 907 62986953
Product storage error 25.11 10.57 50 501112 14906 62972954
Hepatitis fulminant 25.06 10.57 72 501090 3392 62984468
Nail disorder 25.01 10.57 40 501122 12975 62974885
Catheter site pruritus 24.84 10.57 53 501109 2067 62985793
Influenza like illness 24.56 10.57 375 500787 66449 62921411
Heavy menstrual bleeding 24.53 10.57 66 501096 17707 62970153
Stevens-Johnson syndrome 24.49 10.57 303 500859 24647 62963213
Pericardial haemorrhage 24.43 10.57 45 501117 1574 62986286
Eye irritation 24.40 10.57 90 501072 21881 62965979
Haematoma muscle 24.39 10.57 37 501125 1100 62986760
Nephropathy 24.35 10.57 107 501055 6234 62981626
Deformity 24.30 10.57 34 501128 11650 62976210
Exposure to toxic agent 24.22 10.57 7 501155 5580 62982280
Brain natriuretic peptide 24.17 10.57 10 501152 33 62987827
Coagulation time prolonged 24.09 10.57 42 501120 1406 62986454
Sexual dysfunction 24.09 10.57 3 501159 4356 62983504
Gouty tophus 24.09 10.57 18 501144 227 62987633
Electrocardiogram U wave present 24.09 10.57 13 501149 88 62987772
Hyperaesthesia 24.04 10.57 23 501139 9335 62978525
Musculoskeletal disorder 23.97 10.57 83 501079 20561 62967299
Somnolence 23.80 10.57 1677 499485 177008 62810852
Gastrointestinal toxicity 23.67 10.57 16 501146 7725 62980135
Medication error 23.64 10.57 560 500602 51724 62936136
Catheterisation cardiac 23.58 10.57 85 501077 4518 62983342
Nasal congestion 23.52 10.57 682 500480 64978 62922882
Road traffic accident 23.38 10.57 181 500981 36451 62951409
Multiple-drug resistance 23.31 10.57 6 501156 5164 62982696
Catheter placement 23.27 10.57 54 501108 2230 62985630
Chronic sinusitis 23.27 10.57 41 501121 12802 62975058
Continuous haemodiafiltration 23.26 10.57 34 501128 977 62986883
Maternal exposure during breast feeding 23.24 10.57 3 501159 4238 62983622
Catheter site discharge 23.21 10.57 50 501112 1963 62985897
Hepatorenal failure 23.16 10.57 28 501134 666 62987194
Hypothermia 23.15 10.57 185 500977 13396 62974464
Drug level increased 23.14 10.57 278 500884 22458 62965402
Complication of device removal 23.12 10.57 6 501156 5136 62982724
Synovial cyst 23.09 10.57 29 501133 10404 62977456
Haemorrhagic disorder 22.98 10.57 31 501131 825 62987035
Blood sodium increased 22.96 10.57 60 501102 2672 62985188
Wound haemorrhage 22.96 10.57 57 501105 2459 62985401
Gastric disorder 22.76 10.57 187 500975 37182 62950678
Polyarthritis 22.67 10.57 28 501134 10118 62977742
Neutropenia 22.51 10.57 1140 500022 173865 62813995
Transient ischaemic attack 22.48 10.57 421 500741 37332 62950528
Cardiac cirrhosis 22.47 10.57 14 501148 128 62987732
Diastolic dysfunction 22.47 10.57 106 501056 6365 62981495
Hepatojugular reflux 22.47 10.57 8 501154 15 62987845
Cardiac amyloidosis 22.42 10.57 30 501132 792 62987068
Cardiac hypertrophy 22.40 10.57 34 501128 1011 62986849
Product preparation error 22.39 10.57 10 501152 6082 62981778
Dyspnoea at rest 22.34 10.57 77 501085 4002 62983858
Acute respiratory distress syndrome 22.33 10.57 284 500878 23250 62964610
Blood glucose increased 22.30 10.57 840 500322 82916 62904944
Marasmus 22.30 10.57 24 501138 501 62987359
Scleritis 22.28 10.57 4 501158 4424 62983436
Carbon dioxide increased 22.26 10.57 39 501123 1311 62986549
Muscle twitching 22.22 10.57 80 501082 19588 62968272
Volume blood decreased 22.20 10.57 14 501148 131 62987729
Onychomycosis 22.18 10.57 18 501144 7914 62979946
Ureteric rupture 22.15 10.57 7 501155 7 62987853
Renal atrophy 22.12 10.57 41 501121 1441 62986419
Hospitalisation 22.11 10.57 851 500311 84230 62903630
Therapeutic embolisation 22.08 10.57 15 501147 161 62987699
Gouty arthritis 21.98 10.57 25 501137 556 62987304
Irritability 21.95 10.57 153 501009 31541 62956319
Adverse reaction 21.92 10.57 29 501133 10174 62977686
Immunodeficiency 21.82 10.57 84 501078 20170 62967690
Bladder pain 21.82 10.57 53 501109 2255 62985605
Photophobia 21.78 10.57 69 501093 17566 62970294
Palpitations 21.78 10.57 1094 500068 111676 62876184
Malignant neoplasm progression 21.70 10.57 488 500674 81633 62906227
Premature labour 21.69 10.57 41 501121 12463 62975397
Affect lability 21.68 10.57 34 501128 11117 62976743
Ovarian hyperstimulation syndrome 21.61 10.57 3 501159 4011 62983849
Localised oedema 21.61 10.57 92 501070 5286 62982574
Accidental overdose 21.57 10.57 280 500882 23029 62964831
Atrial septal defect repair 21.52 10.57 17 501145 234 62987626
Disturbance in social behaviour 21.46 10.57 3 501159 3990 62983870
Right ventricular enlargement 21.41 10.57 19 501143 310 62987550
Thyroid disorder 21.37 10.57 198 500964 14964 62972896
End stage renal disease 21.35 10.57 107 501055 6586 62981274
Gastric ulcer haemorrhage 21.32 10.57 86 501076 4822 62983038
Antibiotic level above therapeutic 21.22 10.57 20 501142 354 62987506
Hepatorenal syndrome 21.15 10.57 47 501115 1885 62985975
Injection site mass 21.00 10.57 76 501086 18580 62969280
Hypochromic anaemia 20.99 10.57 47 501115 1895 62985965
Urosepsis 20.86 10.57 231 500931 18293 62969567
Staphylococcus test positive 20.86 10.57 73 501089 3823 62984037
Pulmonary fibrosis 20.84 10.57 207 500955 39602 62948258
Hyperprolactinaemia 20.80 10.57 3 501159 3897 62983963
Right ventricular dysfunction 20.76 10.57 45 501117 1774 62986086
Contusion 20.74 10.57 970 500192 149074 62838786
Ocular hyperaemia 20.72 10.57 115 501047 25029 62962831
Duodenal ulcer 20.65 10.57 118 501044 7638 62980222
Hallucination 20.64 10.57 573 500589 54244 62933616
Pain in extremity 20.61 10.57 2296 498866 329190 62658670
Bilirubin conjugated increased 20.59 10.57 59 501103 2775 62985085
Ammonia increased 20.56 10.57 82 501080 4574 62983286
Gastric varices 20.55 10.57 15 501147 182 62987678
Spontaneous haematoma 20.50 10.57 30 501132 863 62986997
Blood creatine phosphokinase increased 20.49 10.57 346 500816 30084 62957776
Joint destruction 20.38 10.57 12 501150 6240 62981620
Intentional product misuse 20.34 10.57 348 500814 60569 62927291
Cystostomy 20.32 10.57 11 501151 75 62987785
Metastases to bone 20.27 10.57 91 501071 20928 62966932
Demyelination 20.24 10.57 15 501147 6905 62980955
Joint effusion 20.21 10.57 68 501094 16992 62970868
Hypertrophic cardiomyopathy 20.14 10.57 41 501121 1546 62986314
Coronary artery occlusion 20.12 10.57 122 501040 8069 62979791
Obesity 20.06 10.57 146 501016 29806 62958054
Tetany 20.05 10.57 47 501115 1954 62985906
Coma 19.98 10.57 657 500505 63707 62924153
Vaginal discharge 19.91 10.57 26 501136 9172 62978688
Neonatal hypocalcaemia 19.90 10.57 8 501154 24 62987836
Disturbance in attention 19.82 10.57 199 500963 37990 62949870
Mucosal dryness 19.81 10.57 57 501105 2687 62985173
Hypercalciuria 19.78 10.57 18 501144 304 62987556
Supraventricular extrasystoles 19.61 10.57 80 501082 4509 62983351
Traumatic haematoma 19.60 10.57 39 501123 1446 62986414
Peripheral embolism 19.55 10.57 36 501126 1259 62986601
Diabetic hyperosmolar coma 19.50 10.57 19 501143 351 62987509
Blood pressure fluctuation 19.47 10.57 253 500909 46064 62941796
Acute motor-sensory axonal neuropathy 19.43 10.57 17 501145 272 62987588
Erythromelalgia 19.41 10.57 13 501149 136 62987724
Sleep disorder due to a general medical condition 19.40 10.57 42 501120 12146 62975714
Pharyngitis streptococcal 19.40 10.57 34 501128 10638 62977222
Pickwickian syndrome 19.37 10.57 19 501143 354 62987506
Pulmonary veno-occlusive disease 19.29 10.57 33 501129 1088 62986772
Eosinophil count increased 19.25 10.57 150 501012 10778 62977082
Pulmonary hypoplasia 19.22 10.57 17 501145 276 62987584
Catheter site haemorrhage 19.22 10.57 62 501100 3113 62984747
Mouth ulceration 19.21 10.57 167 500995 32817 62955043
Skin turgor decreased 19.19 10.57 23 501139 542 62987318
Impaired quality of life 19.16 10.57 51 501111 13732 62974128
Troponin T increased 19.10 10.57 35 501127 1219 62986641
Drug dose omission by device 19.08 10.57 7 501155 4794 62983066
Injection site haemorrhage 19.07 10.57 113 501049 24201 62963659
Clostridium difficile colitis 19.00 10.57 247 500915 20322 62967538
Vascular graft 18.99 10.57 28 501134 811 62987049
Cardioversion 18.98 10.57 35 501127 1225 62986635
Subdural haemorrhage 18.98 10.57 61 501101 3057 62984803
Internal haemorrhage 18.96 10.57 86 501076 5079 62982781
Pallor 18.94 10.57 343 500819 30225 62957635
Supraventricular tachycardia 18.93 10.57 184 500978 14087 62973773
Obstructive airways disorder 18.88 10.57 248 500914 20451 62967409
Injury 18.86 10.57 437 500725 72810 62915050
Poisoning 18.81 10.57 51 501111 13649 62974211
Finger deformity 18.79 10.57 20 501142 7725 62980135
Asterixis 18.78 10.57 37 501125 1362 62986498
Dementia 18.77 10.57 229 500933 18565 62969295
Cardiopulmonary failure 18.76 10.57 67 501095 3545 62984315
Blood urea abnormal 18.72 10.57 25 501137 659 62987201
Dysuria 18.65 10.57 372 500790 33366 62954494
Device deployment issue 18.64 10.57 4 501158 3898 62983962
Rectosigmoid cancer 18.57 10.57 13 501149 147 62987713
Peripheral arterial occlusive disease 18.56 10.57 74 501088 4127 62983733
Weight increased 18.55 10.57 1789 499373 259003 62728857
Gait inability 18.52 10.57 300 500862 52659 62935201
Tumour lysis syndrome 18.47 10.57 128 501034 8862 62978998
Product complaint 18.42 10.57 168 500994 12641 62975219
Aortic valve calcification 18.40 10.57 22 501140 517 62987343
Endocarditis 18.39 10.57 92 501070 5658 62982202
Haemodynamic instability 18.38 10.57 130 501032 9060 62978800
Mitral valve disease 18.38 10.57 52 501110 2428 62985432
Paradoxical drug reaction 18.37 10.57 5 501157 4147 62983713
Fungal infection 18.37 10.57 194 500968 36680 62951180
Pancreatitis acute 18.33 10.57 309 500853 26857 62961003
Pulmonary haemorrhage 18.31 10.57 108 501054 7073 62980787
Retroperitoneal haemorrhage 18.20 10.57 56 501106 2741 62985119
Hyperglycaemic hyperosmolar nonketotic syndrome 18.19 10.57 30 501132 959 62986901
Hiatus hernia 18.17 10.57 255 500907 21339 62966521
Amnesia 18.09 10.57 319 500843 55266 62932594
Frequent bowel movements 18.06 10.57 107 501055 22915 62964945
Uraemic encephalopathy 18.03 10.57 16 501146 261 62987599
Right ventricular dilatation 18 10.57 36 501126 1340 62986520
Mood altered 17.99 10.57 58 501104 14685 62973175
Ischaemia 17.93 10.57 80 501082 4692 62983168
Embolic stroke 17.89 10.57 68 501094 3708 62984152
Electrocardiogram repolarisation abnormality 17.88 10.57 35 501127 1282 62986578
Diabetic nephropathy 17.79 10.57 37 501125 1417 62986443
Neuropathy peripheral 17.74 10.57 725 500437 112942 62874918
Generalised bullous fixed drug eruption 17.71 10.57 11 501151 100 62987760
Malaise 17.70 10.57 3629 497533 412325 62575535
Feeling hot 17.69 10.57 285 500877 50069 62937791
Hepatomegaly 17.64 10.57 157 501005 11732 62976128
Normochromic normocytic anaemia 17.63 10.57 78 501084 4558 62983302
Hyperaldosteronism 17.61 10.57 15 501147 231 62987629
Hypertension 17.55 10.57 1933 499229 277370 62710490
Drug monitoring procedure not performed 17.55 10.57 23 501139 595 62987265
Lung infiltration 17.52 10.57 183 500979 14280 62973580
Sight disability 17.49 10.57 12 501150 131 62987729
Substance abuse 17.49 10.57 8 501154 4799 62983061
Pulmonary artery dilatation 17.45 10.57 16 501146 273 62987587
Metastases to liver 17.43 10.57 112 501050 23527 62964333
Vascular device infection 17.39 10.57 108 501054 7204 62980656
Malignant melanoma 17.37 10.57 40 501122 11316 62976544
Bundle branch block 17.35 10.57 28 501134 879 62986981
Cushingoid 17.34 10.57 25 501137 8460 62979400
Coeliac disease 17.30 10.57 48 501114 12749 62975111
Bradykinesia 17.30 10.57 84 501078 5104 62982756
Lymphorrhoea 17.29 10.57 9 501153 56 62987804
Optic ischaemic neuropathy 17.24 10.57 33 501129 1189 62986671
Intestinal pseudo-obstruction 17.23 10.57 28 501134 884 62986976
Purpura 17.23 10.57 151 501011 11234 62976626
Hypoproteinaemia 17.22 10.57 45 501117 2004 62985856
Cerebral mass effect 17.21 10.57 28 501134 885 62986975
Cardiothoracic ratio increased 17.17 10.57 7 501155 22 62987838
Left ventricle outflow tract obstruction 17.12 10.57 16 501146 280 62987580
Cholecystitis chronic 17.08 10.57 35 501127 10326 62977534
Wrong patient received product 17.07 10.57 47 501115 2160 62985700
Hyperamylasaemia 17.06 10.57 20 501142 460 62987400
Tracheostomy 17.04 10.57 24 501138 666 62987194
Left ventricular hypertrophy 16.97 10.57 85 501077 5230 62982630
Brain natriuretic peptide abnormal 16.94 10.57 18 501144 370 62987490
Cardiac rehabilitation therapy 16.92 10.57 5 501157 3 62987857
Cerebral venous thrombosis 16.87 10.57 45 501117 2029 62985831
Caesarean section 16.87 10.57 73 501089 16959 62970901
Hypertensive heart disease 16.81 10.57 50 501112 2402 62985458
Serotonin syndrome 16.80 10.57 145 501017 28537 62959323
Fryns syndrome 16.79 10.57 9 501153 60 62987800
Superinfection 16.78 10.57 52 501110 2555 62985305
Emotional disorder 16.77 10.57 52 501110 13327 62974533
Hallucination, visual 16.69 10.57 229 500933 19069 62968791
Haemorrhagic stroke 16.68 10.57 90 501072 5702 62982158
Mechanical ventilation 16.67 10.57 34 501128 1284 62986576
Thalamic infarction 16.66 10.57 20 501142 472 62987388
Postpericardiotomy syndrome 16.60 10.57 6 501156 12 62987848
Infective exacerbation of chronic obstructive airways disease 16.58 10.57 33 501129 1224 62986636
Crying 16.51 10.57 112 501050 23231 62964629
Systolic dysfunction 16.50 10.57 38 501124 1561 62986299
Transplant evaluation 16.49 10.57 32 501130 1165 62986695
Infected skin ulcer 16.41 10.57 48 501114 2284 62985576
Apnoea 16.35 10.57 114 501048 7908 62979952
Angiopathy 16.34 10.57 76 501086 4537 62983323
Anosmia 16.33 10.57 18 501144 6842 62981018
Schizoaffective disorder 16.32 10.57 4 501158 3558 62984302
Hypocoagulable state 16.30 10.57 32 501130 1175 62986685
Product prescribing error 16.29 10.57 295 500867 25994 62961866
Burning sensation 16.23 10.57 317 500845 54090 62933770
Menstrual disorder 16.22 10.57 11 501151 5302 62982558
White blood cell count increased 16.20 10.57 500 500662 48061 62939799
Nasal mucosal erosion 16.20 10.57 9 501153 65 62987795
Carpal tunnel syndrome 16.20 10.57 97 501065 20720 62967140
Prothrombin level decreased 16.10 10.57 22 501140 593 62987267
Stasis dermatitis 16.08 10.57 24 501138 703 62987157
Electrocardiogram QT shortened 15.89 10.57 11 501151 122 62987738
Thermohypoaesthesia 15.89 10.57 11 501151 122 62987738
Tongue oedema 15.83 10.57 75 501087 4511 62983349
Haemophagocytic lymphohistiocytosis 15.80 10.57 38 501124 10589 62977271
Full blood count decreased 15.77 10.57 291 500871 25733 62962127
Small for dates baby 15.72 10.57 5 501157 3746 62984114
Extradural haematoma 15.70 10.57 39 501123 1683 62986177
Foetal growth restriction 15.69 10.57 22 501140 7531 62980329
Pulmonary arterial pressure abnormal 15.69 10.57 20 501142 503 62987357
Respiratory alkalosis 15.68 10.57 52 501110 2649 62985211
Exostosis 15.66 10.57 80 501082 17782 62970078
Proctitis 15.65 10.57 12 501150 5429 62982431
Chronic left ventricular failure 15.65 10.57 19 501143 454 62987406
Hypermagnesaemia 15.63 10.57 28 501134 958 62986902
Streptococcal sepsis 15.61 10.57 42 501120 1904 62985956
Tongue disorder 15.59 10.57 38 501124 10542 62977318
Platelet transfusion 15.58 10.57 25 501137 781 62987079
Hyperbilirubinaemia 15.57 10.57 147 501015 11167 62976693
Lymphocyte count decreased 15.56 10.57 158 501004 30099 62957761
Limb reduction defect 15.56 10.57 18 501144 408 62987452
Lip erosion 15.49 10.57 28 501134 965 62986895
Skin graft failure 15.47 10.57 10 501152 98 62987762
Mobility decreased 15.42 10.57 790 500372 120369 62867491
Arteriospasm coronary 15.41 10.57 6 501156 3962 62983898
Electrocardiogram ST-T segment depression 15.40 10.57 4 501158 0 62987860
Gastrointestinal angiodysplasia 15.39 10.57 19 501143 462 62987398
Ear pruritus 15.39 10.57 6 501156 3959 62983901
Pseudoporphyria 15.38 10.57 13 501149 198 62987662
Atrial thrombosis 15.36 10.57 40 501122 1778 62986082
Rash pruritic 15.33 10.57 357 500805 59442 62928418
Catheter site pain 15.31 10.57 76 501086 4659 62983201
Cardiac death 15.31 10.57 21 501141 568 62987292
Heart valve incompetence 15.30 10.57 53 501109 2761 62985099
Hot flush 15.28 10.57 298 500864 50861 62936999
Hypercholesterolaemia 15.27 10.57 102 501060 21232 62966628
Vitamin B1 deficiency 15.25 10.57 16 501146 324 62987536
Optic neuritis 15.21 10.57 27 501135 8408 62979452
Illness 15.20 10.57 284 500878 48775 62939085
Heart transplant 15.18 10.57 20 501142 520 62987340
Seizure 15.18 10.57 874 500288 131760 62856100
Spinal pain 15.14 10.57 53 501109 13086 62974774
Sickle cell anaemia with crisis 15.13 10.57 15 501147 5988 62981872
Dermatitis atopic 15.07 10.57 34 501128 9690 62978170
Platelet dysfunction 15.06 10.57 10 501152 103 62987757
Galactorrhoea 14.99 10.57 7 501155 4148 62983712
Cerebellar haematoma 14.95 10.57 17 501145 378 62987482
Puncture site haemorrhage 14.93 10.57 15 501147 288 62987572
Toxic encephalopathy 14.92 10.57 96 501066 6483 62981377
Suspected suicide 14.81 10.57 18 501144 6550 62981310
Transcription medication error 14.80 10.57 13 501149 209 62987651
Pulmonary vein stenosis 14.75 10.57 9 501153 79 62987781
Hypersensitivity vasculitis 14.75 10.57 68 501094 4044 62983816
Female genital tract fistula 14.74 10.57 23 501139 7536 62980324
Bleeding varicose vein 14.73 10.57 15 501147 293 62987567
Peripheral circulatory failure 14.72 10.57 27 501135 941 62986919
Drug therapeutic incompatibility 14.72 10.57 8 501154 55 62987805
Oesophageal spasm 14.60 10.57 56 501106 3067 62984793
Genital haemorrhage 14.60 10.57 22 501140 7310 62980550
Injection site induration 14.51 10.57 32 501130 9194 62978666
Abdominal hernia 14.51 10.57 78 501084 4934 62982926
Glomerulonephritis 14.51 10.57 39 501123 1767 62986093
Pulse absent 14.47 10.57 82 501080 5292 62982568
Systemic scleroderma 14.47 10.57 27 501135 954 62986906
Pericardial excision 14.46 10.57 6 501156 20 62987840
Urinary retention 14.45 10.57 327 500835 29974 62957886
Catheter removal 14.44 10.57 17 501145 393 62987467
Leukocytosis 14.35 10.57 286 500876 25649 62962211
Portal hypertension 14.33 10.57 64 501098 3755 62984105
Gastric varices haemorrhage 14.32 10.57 11 501151 145 62987715
Dysarthria 14.31 10.57 440 500722 42271 62945589
Blood potassium abnormal 14.28 10.57 49 501113 2541 62985319
Depressed mood 14.27 10.57 227 500935 39964 62947896
Ventricular dyssynchrony 14.26 10.57 8 501154 59 62987801
Cardiac valve replacement complication 14.26 10.57 11 501151 146 62987714
Craniocerebral injury 14.25 10.57 52 501110 2780 62985080
Atrioventricular block second degree 14.24 10.57 65 501097 3849 62984011
Alveolitis 14.23 10.57 53 501109 2862 62984998
Drug specific antibody present 14.14 10.57 8 501154 4251 62983609
Cardiorenal syndrome 14.07 10.57 25 501137 850 62987010
Amyloidosis 14.02 10.57 29 501133 1106 62986754
Crystalluria 14.01 10.57 17 501145 406 62987454
Cataract 13.97 10.57 343 500819 56710 62931150
Device pacing issue 13.94 10.57 9 501153 88 62987772
Mydriasis 13.93 10.57 48 501114 11908 62975952
Rash maculo-papular 13.92 10.57 340 500822 31556 62956304
Long QT syndrome 13.88 10.57 57 501105 3222 62984638
Cleft palate 13.87 10.57 27 501135 985 62986875
Blood lactate dehydrogenase increased 13.84 10.57 258 500904 22858 62965002
Rheumatic heart disease 13.83 10.57 5 501157 10 62987850
Diabetic metabolic decompensation 13.81 10.57 37 501125 1673 62986187
Skin plaque 13.81 10.57 28 501134 8292 62979568
Chronic hepatic failure 13.78 10.57 20 501142 571 62987289
Blood aldosterone increased 13.76 10.57 12 501150 191 62987669
Endometriosis 13.75 10.57 13 501149 5307 62982553
Tuberculosis 13.75 10.57 44 501118 11167 62976693
Ventricular hyperkinesia 13.72 10.57 8 501154 64 62987796
Surgery 13.72 10.57 200 500962 35712 62952148
Multimorbidity 13.70 10.57 20 501142 574 62987286
Catheter site rash 13.62 10.57 23 501139 750 62987110
Glomerulonephritis acute 13.61 10.57 9 501153 92 62987768
Hypoprothrombinaemia 13.60 10.57 14 501148 277 62987583
Hypomania 13.59 10.57 18 501144 6312 62981548
Hypokalaemic syndrome 13.53 10.57 9 501153 93 62987767
Angiotensin converting enzyme inhibitor foetopathy 13.52 10.57 7 501155 43 62987817
Chromaturia 13.51 10.57 196 500966 16521 62971339
Limb hypoplasia congenital 13.46 10.57 12 501150 197 62987663
Intestinal ischaemia 13.43 10.57 103 501059 7365 62980495
Urine sodium decreased 13.43 10.57 11 501151 160 62987700
Rectal polyp 13.41 10.57 30 501132 1209 62986651
Blood pressure diastolic abnormal 13.40 10.57 64 501098 14478 62973382
Congenital nail disorder 13.37 10.57 9 501153 95 62987765
Post transplant lymphoproliferative disorder 13.35 10.57 12 501150 5019 62982841
Peripheral sensory neuropathy 13.30 10.57 24 501138 7427 62980433
Asphyxia 13.29 10.57 89 501073 6092 62981768
Ventricular hypokinesia 13.26 10.57 72 501090 4572 62983288
Fibrin degradation products increased 13.26 10.57 11 501151 163 62987697
Escherichia sepsis 13.22 10.57 76 501086 4931 62982929
Thrombocytopenic purpura 13.21 10.57 32 501130 1359 62986501
Anger 13.20 10.57 52 501110 12404 62975456
Throat tightness 13.20 10.57 129 501033 24758 62963102
Blood antidiuretic hormone increased 13.18 10.57 4 501158 3 62987857
Blood pH increased 13.18 10.57 19 501143 539 62987321
Prothrombin time abnormal 13.18 10.57 18 501144 485 62987375
Hyperparathyroidism primary 13.12 10.57 16 501146 384 62987476
Rheumatoid lung 13.10 10.57 7 501155 3841 62984019
Pseudomembranous colitis 13.10 10.57 54 501108 3058 62984802
Biopsy liver 13.09 10.57 16 501146 385 62987475
Polymyalgia rheumatica 13.09 10.57 62 501100 3729 62984131
Upper respiratory tract infection 13.08 10.57 522 500640 81525 62906335
Feeling cold 13.07 10.57 263 500899 23625 62964235
International normalised ratio 13.06 10.57 9 501153 99 62987761
Myoglobin blood increased 13.00 10.57 32 501130 1373 62986487
Second primary malignancy 13.00 10.57 27 501135 7926 62979934
Face oedema 12.95 10.57 228 500934 19984 62967876
Gastric ulcer 12.94 10.57 264 500898 23773 62964087
Cough 12.94 10.57 2559 498603 290184 62697676
Neonatal cholestasis 12.90 10.57 7 501155 48 62987812
Right atrial enlargement 12.88 10.57 10 501152 134 62987726
Brain compression 12.81 10.57 16 501146 394 62987466
Anal fistula 12.78 10.57 6 501156 3545 62984315
Neutrophil count decreased 12.77 10.57 343 500819 56063 62931797
Cerebral hypoperfusion 12.76 10.57 15 501147 346 62987514
Anti-neutrophil cytoplasmic antibody positive vasculitis 12.76 10.57 51 501111 2848 62985012
Stillbirth 12.73 10.57 21 501141 6729 62981131
Dysaesthesia 12.72 10.57 10 501152 4468 62983392
Abortion induced 12.70 10.57 40 501122 10202 62977658
Gastrointestinal vascular malformation haemorrhagic 12.70 10.57 12 501150 213 62987647
Bronchopulmonary aspergillosis allergic 12.69 10.57 43 501119 2215 62985645
Clostridial sepsis 12.69 10.57 18 501144 503 62987357
Upper-airway cough syndrome 12.68 10.57 142 501020 11276 62976584
Blood creatine phosphokinase MB increased 12.66 10.57 29 501133 1187 62986673
Hypertensive crisis 12.66 10.57 180 500982 15106 62972754
Breast pain 12.66 10.57 32 501130 8766 62979094
Haemarthrosis 12.64 10.57 54 501108 3107 62984753
Haemothorax 12.63 10.57 42 501120 2143 62985717
Malnutrition 12.61 10.57 180 500982 15118 62972742
Arteriovenous malformation 12.61 10.57 31 501131 1329 62986531
Biliary catheter insertion 12.58 10.57 6 501156 30 62987830
Neutropenic sepsis 12.58 10.57 77 501085 16361 62971499
Nocturnal dyspnoea 12.54 10.57 29 501133 1195 62986665
Hepatic steatosis 12.52 10.57 156 501006 28613 62959247
Hip fracture 12.51 10.57 313 500849 29161 62958699
Right atrial pressure increased 12.46 10.57 10 501152 141 62987719
Deafness bilateral 12.46 10.57 32 501130 1410 62986450
Diffuse large B-cell lymphoma refractory 12.44 10.57 29 501133 1201 62986659
Inflammatory bowel disease 12.43 10.57 8 501154 3965 62983895
Dysmenorrhoea 12.43 10.57 8 501154 3965 62983895
Oxygen saturation abnormal 12.39 10.57 58 501104 3471 62984389
Deafness neurosensory 12.39 10.57 12 501150 4843 62983017
Respiration abnormal 12.39 10.57 90 501072 6327 62981533
Haemorrhagic transformation stroke 12.36 10.57 29 501133 1206 62986654
Anal abscess 12.35 10.57 11 501151 4621 62983239
Somatic delusion 12.32 10.57 19 501143 573 62987287
Anaemia macrocytic 12.30 10.57 57 501105 3397 62984463
Human herpesvirus 6 infection 12.29 10.57 4 501158 2953 62984907
Myocardial necrosis 12.27 10.57 11 501151 182 62987678
Autoimmune haemolytic anaemia 12.25 10.57 70 501092 4531 62983329
Urinary tract candidiasis 12.25 10.57 19 501143 576 62987284
Hyperthyroidism 12.24 10.57 173 500989 14500 62973360
Peripheral ischaemia 12.20 10.57 73 501089 4805 62983055
Dermatitis allergic 12.10 10.57 70 501092 15078 62972782
Sputum retention 12.08 10.57 19 501143 583 62987277
Cyanosis central 12.08 10.57 8 501154 82 62987778
Peripheral coldness 12.05 10.57 148 501014 12017 62975843
Cystitis escherichia 12.04 10.57 18 501144 528 62987332
Right ventricular systolic pressure increased 12.02 10.57 18 501144 529 62987331
Injury associated with device 12.00 10.57 7 501155 3659 62984201
Premature rupture of membranes 12.00 10.57 13 501149 4980 62982880
Incorrect dose administered by device 11.99 10.57 10 501152 4338 62983522
Rash scarlatiniform 11.95 10.57 9 501153 115 62987745
Catheter site irritation 11.94 10.57 18 501144 532 62987328
Rash morbilliform 11.94 10.57 55 501107 3270 62984590
Paranasal sinus discomfort 11.93 10.57 67 501095 4309 62983551
Blood iron abnormal 11.87 10.57 8 501154 3868 62983992
Cardiac ablation 11.86 10.57 32 501130 1453 62986407
Diabetic foot infection 11.79 10.57 11 501151 192 62987668
Heart sounds 11.78 10.57 25 501137 971 62986889
Small intestine gangrene 11.78 10.57 4 501158 6 62987854
Troponin 11.78 10.57 4 501158 6 62987854
Base excess negative 11.78 10.57 4 501158 6 62987854
Blood culture negative 11.74 10.57 10 501152 154 62987706
Affective disorder 11.70 10.57 19 501143 6127 62981733
Urine chloride decreased 11.69 10.57 8 501154 87 62987773
Mania 11.65 10.57 54 501108 12313 62975547
Congenital oral malformation 11.61 10.57 11 501151 196 62987664
Paranoia 11.60 10.57 50 501112 11629 62976231
PO2 decreased 11.58 10.57 32 501130 1474 62986386
Cardiac resynchronisation therapy 11.56 10.57 5 501157 19 62987841
Urine chloride increased 11.55 10.57 3 501159 0 62987860
Medical observation 11.55 10.57 3 501159 0 62987860
Benign small intestinal neoplasm 11.55 10.57 3 501159 0 62987860
Thyroid gland scan abnormal 11.55 10.57 3 501159 0 62987860
Oedema due to renal disease 11.55 10.57 3 501159 0 62987860
Venous pressure increased 11.55 10.57 3 501159 0 62987860
Tracheal operation 11.55 10.57 3 501159 0 62987860
Erysipelas 11.53 10.57 104 501058 7801 62980059
Electrocardiogram abnormal 11.52 10.57 117 501045 9062 62978798
Mental disorder 11.49 10.57 140 501022 25779 62962081
Carbon dioxide abnormal 11.48 10.57 10 501152 159 62987701
Fluid intake reduced 11.47 10.57 58 501104 3583 62984277
Cardiac function test abnormal 11.46 10.57 8 501154 90 62987770
Skin weeping 11.45 10.57 21 501141 732 62987128
Paroxysmal arrhythmia 11.44 10.57 6 501156 38 62987822
Mucosal erosion 11.44 10.57 32 501130 1484 62986376
Lower limb fracture 11.44 10.57 129 501033 24092 62963768
Hypochromasia 11.42 10.57 14 501148 338 62987522
Erythrodermic psoriasis 11.41 10.57 25 501137 993 62986867
Arterial fibrosis 11.41 10.57 4 501158 7 62987853
Patent ductus arteriosus repair 11.36 10.57 5 501157 20 62987840
Leukaemic infiltration renal 11.36 10.57 5 501157 20 62987840
Rectal prolapse 11.36 10.57 38 501124 1945 62985915
Rheumatic disorder 11.36 10.57 5 501157 3067 62984793
Dry skin 11.35 10.57 352 500810 56535 62931325
Mouth haemorrhage 11.35 10.57 92 501070 6691 62981169
Treatment noncompliance 11.33 10.57 380 500782 36945 62950915
Intervertebral disc protrusion 11.31 10.57 126 501036 23583 62964277
Prolonged expiration 11.26 10.57 26 501136 1070 62986790
Nightmare 11.26 10.57 97 501065 19097 62968763
Varices oesophageal 11.25 10.57 52 501110 3096 62984764
Ataxia 11.20 10.57 72 501090 15123 62972737
Haemorrhoids 11.19 10.57 241 500921 21909 62965951
Peritonitis 11.17 10.57 194 500968 16960 62970900
Maternal drugs affecting foetus 11.16 10.57 15 501147 5227 62982633
Rhinorrhoea 11.16 10.57 414 500748 65163 62922697
Infection susceptibility increased 11.14 10.57 7 501155 3514 62984346
Congenital diaphragmatic hernia 11.13 10.57 11 501151 207 62987653
Skin laceration 11.13 10.57 246 500916 22462 62965398
Angioplasty 11.12 10.57 30 501132 1362 62986498
QRS axis abnormal 11.12 10.57 26 501136 1079 62986781
Cerebellar haemorrhage 11.09 10.57 30 501132 1364 62986496
Tuberculin test positive 11.08 10.57 7 501155 3504 62984356
Diverticulum 11.08 10.57 144 501018 11847 62976013
Chemical burn of oral cavity 11.06 10.57 7 501155 66 62987794
Cystitis klebsiella 11.04 10.57 11 501151 209 62987651
Drug tolerance 11.02 10.57 24 501138 6925 62980935
Catarrh 11.01 10.57 32 501130 1517 62986343
Hypoglycaemic unconsciousness 10.98 10.57 21 501141 756 62987104
Ventricular enlargement 10.97 10.57 7 501155 67 62987793
Left atrial dilatation 10.96 10.57 36 501126 1825 62986035
Electrocardiogram T wave peaked 10.92 10.57 11 501151 212 62987648
Nephritis allergic 10.92 10.57 11 501151 212 62987648
Acid base balance abnormal 10.91 10.57 12 501150 257 62987603
Tongue dry 10.91 10.57 25 501137 1024 62986836
Drug withdrawal syndrome 10.90 10.57 150 501012 27044 62960816
Humerus fracture 10.89 10.57 113 501049 8803 62979057
Sodium retention 10.87 10.57 9 501153 133 62987727
Renal tubular disorder 10.87 10.57 46 501116 2636 62985224
Joint laxity 10.84 10.57 3 501159 2461 62985399
Aphthous ulcer 10.82 10.57 65 501097 13873 62973987
Proteus infection 10.77 10.57 26 501136 1102 62986758
PO2 abnormal 10.76 10.57 4 501158 9 62987851
Cervical dysplasia 10.72 10.57 6 501156 3208 62984652
Blood parathyroid hormone increased 10.72 10.57 50 501112 2988 62984872
Anaemia of chronic disease 10.70 10.57 39 501123 2084 62985776
Portal hypertensive gastropathy 10.70 10.57 21 501141 771 62987089
Shunt occlusion 10.69 10.57 19 501143 646 62987214
Sensitivity to weather change 10.66 10.57 26 501136 7211 62980649
Ammonia abnormal 10.65 10.57 9 501153 137 62987723
Therapy interrupted 10.64 10.57 186 500976 32269 62955591
Foot operation 10.64 10.57 26 501136 7205 62980655
Mitral valve calcification 10.61 10.57 24 501138 974 62986886
Calcification metastatic 10.61 10.57 10 501152 177 62987683
Walking aid user 10.57 10.57 46 501116 10671 62977189
Neuroleptic malignant syndrome 10.57 10.57 54 501108 12002 62975858

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure congestive 1934.05 11.62 3370 382693 79900 34490968
Acute kidney injury 1920.46 11.62 7532 378531 297456 34273412
Cardiac failure 1344.17 11.62 3053 383010 88195 34482673
Hyperkalaemia 1022.69 11.62 2323 383740 67066 34503802
Drug ineffective 997.04 11.62 2239 383824 454512 34116356
Drug abuse 614.57 11.62 167 385896 98929 34471939
Oedema peripheral 589.81 11.62 2753 383310 117059 34453809
Off label use 583.78 11.62 2521 383542 417003 34153865
Renal failure 534.33 11.62 2847 383216 127710 34443158
Hypotension 532.99 11.62 4225 381838 217424 34353444
International normalised ratio increased 458.38 11.62 1354 384709 45973 34524895
Dyspnoea 418.89 11.62 6150 379913 370632 34200236
Completed suicide 389.34 11.62 308 385755 97860 34473008
Atrial fibrillation 388.26 11.62 2496 383567 119897 34450971
Toxicity to various agents 382.56 11.62 1049 385014 199313 34371555
Blood creatinine increased 363.86 11.62 2035 384028 92941 34477927
Cardiac failure chronic 358.66 11.62 439 385624 7440 34563428
Blood urea increased 328.24 11.62 904 385159 29460 34541408
Oedema 302.56 11.62 1151 384912 44590 34526278
Renal impairment 297.41 11.62 1924 384139 92589 34478279
Hypokalaemia 297.29 11.62 1353 384710 56861 34514007
Fluid retention 292.12 11.62 802 385261 26085 34544783
Hepatic encephalopathy 251.72 11.62 523 385540 14162 34556706
Pulmonary hypertension 240.21 11.62 637 385426 20287 34550581
Chronic kidney disease 229.44 11.62 983 385080 40227 34530641
Melaena 213.44 11.62 865 385198 34515 34536353
Arthralgia 205.76 11.62 1072 384991 168969 34401899
Treatment failure 204.03 11.62 132 385931 46565 34524303
Product use in unapproved indication 203.72 11.62 643 385420 116856 34454012
Hypervolaemia 196.55 11.62 570 385493 19139 34551729
Anaemia 191.79 11.62 3629 382434 229706 34341162
Suicide attempt 188.76 11.62 98 385965 39018 34531850
Intentional product misuse 185.93 11.62 139 385924 45472 34525396
Hyponatraemia 183.74 11.62 1550 384513 81141 34489727
Bradycardia 183.40 11.62 1443 384620 73975 34496893
Ventricular tachycardia 182.47 11.62 677 385386 25902 34544966
Suicidal ideation 182.20 11.62 110 385953 40278 34530590
Pleural effusion 181.43 11.62 1529 384534 80017 34490851
Headache 181.34 11.62 1384 384679 199251 34371617
Orthostatic hypotension 176.95 11.62 659 385404 25260 34545608
Intentional overdose 176.86 11.62 134 385929 43540 34527328
Dehydration 176.46 11.62 2202 383861 127767 34443101
Ejection fraction decreased 168.46 11.62 530 385533 18624 34552244
Pulmonary oedema 167.16 11.62 996 385067 46533 34524335
Therapeutic product effect incomplete 166.86 11.62 187 385876 50354 34520514
Hypoglycaemia 166.03 11.62 1103 384960 53537 34517331
Syncope 165.51 11.62 1640 384423 89811 34481057
Gastrointestinal haemorrhage 164.68 11.62 1596 384467 86881 34483987
Foetal exposure during pregnancy 164.68 11.62 109 385954 37992 34532876
N-terminal prohormone brain natriuretic peptide increased 161.97 11.62 174 385889 2541 34568327
Rheumatoid arthritis 159.14 11.62 114 385949 38124 34532744
Myocardial infarction 158.18 11.62 2037 384026 119048 34451820
Fall 155.59 11.62 3123 382940 199762 34371106
Intentional product use issue 155.59 11.62 263 385800 59553 34511315
Neutropenia 149.45 11.62 1065 384998 155713 34415155
Cardiac failure acute 148.92 11.62 348 385715 10222 34560646
Injection site pain 148.77 11.62 127 385936 38878 34531990
Pulmonary arterial hypertension 143.67 11.62 306 385757 8433 34562435
Febrile neutropenia 143.24 11.62 904 385159 135945 34434923
Ascites 138.39 11.62 935 385128 45636 34525232
Lactic acidosis 136.90 11.62 751 385312 34021 34536847
Mitral valve incompetence 134.65 11.62 417 385646 14526 34556342
Generalised oedema 131.65 11.62 367 385696 12041 34558827
Product dose omission issue 130.88 11.62 780 385283 118931 34451937
Drug dependence 130.35 11.62 52 386011 24165 34546703
Blood potassium increased 130.26 11.62 440 385623 16055 34554813
Orthopnoea 129.26 11.62 215 385848 4888 34565980
Dyspnoea exertional 122.13 11.62 858 385205 42421 34528447
Right ventricular failure 119.19 11.62 285 385778 8499 34562369
Coronary artery disease 118.88 11.62 927 385136 47378 34523490
Drug interaction 118.53 11.62 3300 382763 222646 34348222
Hypovolaemia 117.20 11.62 292 385771 8942 34561926
Pyrexia 116.36 11.62 2796 383267 330217 34240651
Nausea 114.38 11.62 2870 383193 337038 34233830
COVID-19 111.36 11.62 459 385604 77091 34493777
Drug hypersensitivity 110.49 11.62 485 385578 80044 34490824
Chronic obstructive pulmonary disease 109.66 11.62 919 385144 47999 34522869
Rectal haemorrhage 109.54 11.62 791 385272 39458 34531410
Infusion related reaction 108.44 11.62 268 385795 52789 34518079
Psychotic disorder 105.59 11.62 70 385993 24382 34546486
Musculoskeletal stiffness 104.93 11.62 224 385839 46456 34524412
Tricuspid valve incompetence 104.85 11.62 290 385773 9470 34561398
Therapeutic product effect decreased 104.66 11.62 138 385925 34605 34536263
Pain 104.33 11.62 1611 384452 203064 34367804
Drug intolerance 102.43 11.62 327 385736 59243 34511625
Congestive cardiomyopathy 101.18 11.62 243 385820 7267 34563601
Respiratory failure 101.05 11.62 1723 384340 106849 34464019
Product use issue 100.53 11.62 359 385704 62857 34508011
Hepatic failure 97.08 11.62 684 385379 33847 34537021
Sinusitis 97.01 11.62 194 385869 41208 34529660
Seizure 95.17 11.62 722 385341 104135 34466733
Ischaemic cardiomyopathy 95.14 11.62 215 385848 6174 34564694
Shock haemorrhagic 95.12 11.62 309 385754 11045 34559823
Urticaria 94.75 11.62 361 385702 62016 34508852
Acute pulmonary oedema 92.98 11.62 232 385831 7111 34563757
Cardiomegaly 92.71 11.62 377 385686 15061 34555807
Gout 92.68 11.62 440 385623 18813 34552055
Synovitis 92.34 11.62 21 386042 14045 34556823
Rales 91.09 11.62 278 385785 9605 34561263
Nasopharyngitis 90.25 11.62 431 385632 69537 34501331
Brain natriuretic peptide increased 89.41 11.62 195 385868 5464 34565404
Gravitational oedema 89.34 11.62 68 385995 612 34570256
Blood pressure decreased 88.86 11.62 915 385148 50600 34520268
Rash 87.95 11.62 1834 384229 220918 34349950
Appendicitis 87.92 11.62 27 386036 14780 34556088
Aggression 87.55 11.62 187 385876 38777 34532091
Prostate cancer 86.03 11.62 194 385869 39455 34531413
Acute myocardial infarction 84.66 11.62 937 385126 52782 34518086
Metabolic alkalosis 83.97 11.62 93 385970 1408 34569460
Hypernatraemia 82.20 11.62 243 385820 8247 34562621
Drug ineffective for unapproved indication 81.29 11.62 85 385978 23630 34547238
Renal injury 80.91 11.62 290 385773 10905 34559963
Sedation 79.36 11.62 69 385994 20937 34549931
Psoriatic arthropathy 78.54 11.62 62 386001 19736 34551132
Drug withdrawal syndrome 75.11 11.62 65 385998 19769 34551099
Anuria 75.04 11.62 269 385794 10116 34560752
Multiple sclerosis relapse 74.37 11.62 26 386037 13107 34557761
Mucosal inflammation 73.62 11.62 202 385861 38420 34532448
Depression 72.26 11.62 704 385359 96394 34474474
Urine output decreased 71.50 11.62 259 385804 9790 34561078
Immune reconstitution inflammatory syndrome 71.36 11.62 7 386056 8752 34562116
Rhabdomyolysis 70.92 11.62 1102 384961 67061 34503807
Glomerular filtration rate decreased 70.42 11.62 307 385756 12654 34558214
Insomnia 70.11 11.62 771 385292 103136 34467732
Myocardial ischaemia 69.86 11.62 378 385685 17030 34553838
Inappropriate schedule of product administration 69.02 11.62 404 385659 61892 34508976
Joint swelling 68.72 11.62 384 385679 59506 34511362
Cardiomyopathy 68.14 11.62 366 385697 16442 34554426
Hypersensitivity 68.06 11.62 395 385668 60640 34510228
Left ventricular dysfunction 67.91 11.62 254 385809 9753 34561115
Venous pressure jugular increased 67.57 11.62 62 386001 739 34570129
Intentional self-injury 67.17 11.62 34 386029 13737 34557131
Arthropathy 66.59 11.62 122 385941 26785 34544083
Accidental exposure to product 66.46 11.62 29 386034 12773 34558095
Colitis 66.45 11.62 205 385858 37545 34533323
Injury 65.46 11.62 422 385641 20265 34550603
Fear 65.44 11.62 259 385804 10217 34560651
Asthenia 64.83 11.62 3320 382743 241931 34328937
Vomiting 64.15 11.62 2166 383897 245455 34325413
Cardiac arrest 63.75 11.62 1450 384613 94709 34476159
Exposure during pregnancy 63.54 11.62 11 386052 8923 34561945
Left ventricular failure 63.54 11.62 161 385902 4983 34565885
Haematoma 62.21 11.62 490 385573 25115 34545753
Coronary artery bypass 62.20 11.62 155 385908 4747 34566121
Presyncope 61.67 11.62 391 385672 18668 34552200
Akathisia 59.89 11.62 9 386054 8100 34562768
Azotaemia 59.84 11.62 154 385909 4813 34566055
Fatigue 59.68 11.62 3418 382645 367235 34203633
Irritability 59.29 11.62 114 385949 24576 34546292
Anaphylactic reaction 58.58 11.62 173 385890 32128 34538740
Vitamin B1 deficiency 58.50 11.62 40 386023 299 34570569
Poisoning 58.42 11.62 31 386032 12195 34558673
Infection 58.41 11.62 682 385381 90233 34480635
Haemoglobin decreased 58.21 11.62 1746 384317 119026 34451842
Cardiac disorder 58.10 11.62 730 385333 42396 34528472
Neuropathy peripheral 58.09 11.62 613 385450 82650 34488218
Injection site reaction 58.06 11.62 36 386027 12997 34557871
Injection site erythema 57.93 11.62 54 386009 15845 34555023
Hepatic cirrhosis 57.77 11.62 358 385705 16956 34553912
Jugular vein distension 57.06 11.62 52 386011 614 34570254
Diastolic dysfunction 56.31 11.62 174 385889 6053 34564815
Overdose 54.73 11.62 693 385370 90366 34480502
Arrhythmia 54.32 11.62 620 385443 35188 34535680
Haematotoxicity 54.26 11.62 12 386051 8182 34562686
Malignant neoplasm progression 54.07 11.62 667 385396 87379 34483489
Pathogen resistance 53.30 11.62 19 386044 9463 34561405
Eosinophilia 53.20 11.62 482 385581 25740 34545128
Pemphigoid 53.13 11.62 213 385850 8453 34562415
Atrioventricular block 52.52 11.62 202 385861 7861 34563007
Drug resistance 52.15 11.62 132 385931 25795 34545073
Uveitis 52.04 11.62 10 386053 7525 34563343
Aortic stenosis 51.35 11.62 134 385929 4224 34566644
Cardioactive drug level increased 51.28 11.62 78 385985 1639 34569229
Schizophrenia 51.10 11.62 16 386047 8650 34562218
Sopor 51.07 11.62 267 385796 11869 34558999
Anhedonia 51.04 11.62 192 385871 7393 34563475
Migraine 51.04 11.62 71 385992 17407 34553461
Therapeutic response shortened 50.76 11.62 10 386053 7394 34563474
Torsade de pointes 49.77 11.62 184 385879 7025 34563843
Back pain 49.67 11.62 997 385066 120792 34450076
Colitis ulcerative 49.36 11.62 66 385997 16454 34554414
Oliguria 49.02 11.62 203 385860 8177 34562691
Substance abuse 48.99 11.62 12 386051 7629 34563239
Hallucination, auditory 48.96 11.62 36 386027 11881 34558987
Dyspnoea paroxysmal nocturnal 48.94 11.62 71 385992 1428 34569440
Bundle branch block left 48.54 11.62 161 385902 5818 34565050
Nephrolithiasis 48.37 11.62 172 385891 30161 34540707
Hypoglycaemic coma 48.16 11.62 92 385971 2339 34568529
Respiratory depression 47.43 11.62 66 385997 16179 34554689
Blood creatine increased 47.26 11.62 141 385922 4810 34566058
Device interaction 47.07 11.62 44 386019 538 34570330
Cytomegalovirus infection 46.65 11.62 141 385922 25994 34544874
Therapy partial responder 46.51 11.62 24 386039 9592 34561276
Atrial flutter 46.42 11.62 313 385750 15261 34555607
Paraesthesia 46.16 11.62 469 385594 63703 34507165
Haematuria 45.96 11.62 793 385270 49273 34521595
Concomitant disease progression 45.89 11.62 92 385971 2426 34568442
Neoplasm progression 45.81 11.62 120 385943 23180 34547688
Memory impairment 45.32 11.62 286 385777 43032 34527836
Diabetic ketoacidosis 45.30 11.62 81 385982 17951 34552917
Infective pulmonary exacerbation of cystic fibrosis 44.95 11.62 10 386053 6791 34564077
Concomitant disease aggravated 44.94 11.62 152 385911 5549 34565319
Syringe issue 44.92 11.62 5 386058 5659 34565209
Neutrophil count decreased 44.86 11.62 355 385708 50749 34520119
Stomatitis 44.83 11.62 280 385783 42234 34528634
Product storage error 44.43 11.62 17 386046 8105 34562763
Lymphadenopathy 44.33 11.62 163 385900 28300 34542568
Hypoaesthesia 43.81 11.62 450 385613 60994 34509874
Serotonin syndrome 43.66 11.62 97 385966 19836 34551032
Sleep disorder 43.33 11.62 191 385872 31497 34539371
Gastrointestinal disorder 42.66 11.62 211 385852 33737 34537131
Epistaxis 42.60 11.62 891 385172 57360 34513508
Abnormal behaviour 42.25 11.62 138 385925 24831 34546037
Erythema 42.05 11.62 708 385355 88072 34482796
Left ventricular dilatation 42.01 11.62 47 386016 720 34570148
Cardiac amyloidosis 41.93 11.62 60 386003 1191 34569677
Erectile dysfunction 41.56 11.62 105 385958 20532 34550336
Agitation 41.49 11.62 419 385644 56980 34513888
Chills 41.48 11.62 637 385426 80406 34490462
Acute respiratory failure 41.43 11.62 523 385540 30405 34540463
Hypocalcaemia 41.19 11.62 430 385633 23859 34547009
Abdominal pain 41.18 11.62 1436 384627 162182 34408686
Injection site swelling 41.01 11.62 40 386023 11487 34559381
Device issue 40.86 11.62 29 386034 9748 34561120
Loss of personal independence in daily activities 40.68 11.62 208 385855 32971 34537897
Iron deficiency anaemia 40.57 11.62 223 385840 10106 34560762
Blood potassium decreased 40.35 11.62 337 385726 17578 34553290
Diplopia 40.24 11.62 78 385985 16765 34554103
Generalised tonic-clonic seizure 40.16 11.62 111 385952 21063 34549805
Euphoric mood 40.00 11.62 7 386056 5634 34565234
No adverse event 39.99 11.62 125 385938 22802 34548066
Polyuria 39.85 11.62 194 385869 8380 34562488
Oesophageal varices haemorrhage 39.41 11.62 99 385964 3047 34567821
Upper gastrointestinal haemorrhage 39.22 11.62 443 385620 25075 34545793
Blood pressure fluctuation 39.05 11.62 145 385918 25104 34545764
Hepatorenal syndrome 38.90 11.62 89 385974 2577 34568291
C-reactive protein abnormal 38.88 11.62 24 386039 8686 34562182
Peripheral swelling 38.88 11.62 1114 384949 75427 34495441
Hyperuricaemia 38.84 11.62 184 385879 7859 34563009
Dialysis 38.81 11.62 234 385829 10974 34559894
Vascular purpura 38.62 11.62 70 385993 1708 34569160
Paranoia 38.35 11.62 46 386017 12022 34558846
Somnolence 38.31 11.62 934 385129 110182 34460686
Multiple-drug resistance 38.27 11.62 6 386057 5233 34565635
Therapeutic response decreased 38.11 11.62 180 385883 29133 34541735
Low cardiac output syndrome 38.10 11.62 40 386023 568 34570300
Vision blurred 37.74 11.62 325 385738 45638 34525230
Hepatotoxicity 37.57 11.62 117 385946 21368 34549500
Ventricular extrasystoles 37.40 11.62 244 385819 11764 34559104
Cardiorenal syndrome 37.38 11.62 43 386020 680 34570188
Cardiogenic shock 37.32 11.62 454 385609 26164 34544704
White blood cell count decreased 36.93 11.62 788 385275 94657 34476211
Prothrombin time prolonged 36.90 11.62 203 385860 9203 34561665
Haemodialysis 36.60 11.62 220 385843 10306 34560562
Blood pressure increased 36.57 11.62 719 385344 87383 34483485
Neuroleptic malignant syndrome 36.30 11.62 91 385972 17843 34553025
Hypoxia 36.23 11.62 830 385233 54265 34516603
Cardiac murmur 36.19 11.62 177 385886 7660 34563208
Anxiety 36.14 11.62 829 385234 98599 34472269
Aortic valve incompetence 36.10 11.62 145 385918 5759 34565109
Anger 35.99 11.62 47 386016 11837 34559031
Mental disorder 35.84 11.62 71 385992 15138 34555730
Hyperhidrosis 35.72 11.62 604 385459 75088 34495780
Ankylosing spondylitis 35.54 11.62 9 386054 5595 34565273
Pneumonia 35.40 11.62 4546 381517 358081 34212787
Subdural haematoma 35.33 11.62 363 385700 20058 34550810
International normalised ratio decreased 35.33 11.62 121 385942 4446 34566422
Incorrect route of product administration 35.24 11.62 69 385994 14776 34556092
Troponin increased 35.22 11.62 231 385832 11158 34559710
Acrodermatitis enteropathica 35.17 11.62 10 386053 0 34570868
Arthritis 34.86 11.62 203 385860 31143 34539725
Depressed mood 34.63 11.62 104 385959 19213 34551655
Abdominal discomfort 34.60 11.62 459 385604 59376 34511492
Disturbance in attention 34.51 11.62 158 385905 25787 34545081
Alopecia 34.40 11.62 145 385918 24210 34546658
Night sweats 34.39 11.62 89 385974 17263 34553605
Myelosuppression 34.34 11.62 104 385959 19161 34551707
Tinnitus 34.17 11.62 111 385952 20007 34550861
Systemic infection 33.78 11.62 8 386055 5204 34565664
Post transplant lymphoproliferative disorder 33.55 11.62 15 386048 6513 34564355
Drug reaction with eosinophilia and systemic symptoms 33.28 11.62 531 385532 32481 34538387
Extrapyramidal disorder 33.13 11.62 57 386006 12823 34558045
Toxic epidermal necrolysis 32.92 11.62 375 385688 21271 34549597
Cardiac output decreased 32.90 11.62 45 386018 855 34570013
Diverticulitis 32.86 11.62 112 385951 19892 34550976
Hypocoagulable state 32.63 11.62 46 386017 900 34569968
Amnesia 32.29 11.62 167 385896 26396 34544472
Hypercreatinaemia 32.22 11.62 22 386041 164 34570704
Transfusion 32.16 11.62 183 385880 8402 34562466
Sudden cardiac death 32.16 11.62 102 385961 3599 34567269
Withdrawal syndrome 32.14 11.62 55 386008 12400 34558468
Pulmonary congestion 32.11 11.62 261 385802 13504 34557364
Gastrointestinal tract mucosal pigmentation 32.08 11.62 33 386030 457 34570411
Dilatation atrial 32.01 11.62 70 385993 1965 34568903
Acute graft versus host disease 31.80 11.62 16 386047 6487 34564381
Muscle spasms 31.76 11.62 610 385453 74391 34496477
Tenosynovitis 31.70 11.62 6 386057 4564 34566304
Tremor 31.60 11.62 683 385380 81904 34488964
Sexual dysfunction 31.59 11.62 15 386048 6288 34564580
Blood lactic acid 31.59 11.62 28 386035 318 34570550
Left ventricular hypertrophy 31.58 11.62 175 385888 7955 34562913
Nightmare 31.54 11.62 70 385993 14321 34556547
Haematemesis 31.51 11.62 455 385608 27256 34543612
Polyomavirus-associated nephropathy 31.51 11.62 3 386060 3841 34567027
Injection site haemorrhage 31.29 11.62 37 386026 9731 34561137
Atrioventricular block complete 30.65 11.62 192 385871 9127 34561741
Peritonitis bacterial 30.40 11.62 141 385922 5969 34564899
Emotional distress 30.37 11.62 276 385787 14750 34556118
Nephrotic syndrome 30.26 11.62 160 385903 7143 34563725
Progressive multifocal leukoencephalopathy 30.21 11.62 38 386025 9726 34561142
Cor pulmonale 30.13 11.62 41 386022 775 34570093
Dyspnoea at rest 30.12 11.62 102 385961 3726 34567142
Anal abscess 30.07 11.62 17 386046 6456 34564412
Acute graft versus host disease in skin 29.96 11.62 10 386053 5191 34565677
Congestive hepatopathy 29.92 11.62 65 385998 1816 34569052
Muscle twitching 29.90 11.62 42 386021 10256 34560612
Bradyarrhythmia 29.63 11.62 71 385992 2120 34568748
Blood loss anaemia 29.61 11.62 173 385890 8021 34562847
Hyperparathyroidism secondary 29.43 11.62 58 386005 1510 34569358
Influenza like illness 29.13 11.62 182 385881 27452 34543416
Pruritus 28.96 11.62 1277 384786 140704 34430164
Exercise tolerance decreased 28.91 11.62 124 385939 5074 34565794
Panic attack 28.88 11.62 37 386026 9395 34561473
Alanine aminotransferase abnormal 28.84 11.62 8 386055 4680 34566188
Dystonia 28.81 11.62 47 386016 10798 34560070
Hepatocellular carcinoma 28.75 11.62 161 385902 7348 34563520
Metabolic acidosis 28.70 11.62 658 385405 43022 34527846
Left ventricular enlargement 28.58 11.62 37 386026 665 34570203
Mucormycosis 28.49 11.62 15 386048 5927 34564941
Left atrial enlargement 28.29 11.62 42 386021 863 34570005
Cognitive disorder 28.21 11.62 193 385870 28500 34542368
Frequent bowel movements 28.19 11.62 62 386001 12725 34558143
Asthma 28.15 11.62 318 385745 42338 34528530
Scrotal oedema 27.80 11.62 62 386001 1764 34569104
Multiple organ dysfunction syndrome 27.75 11.62 1071 384992 75495 34495373
Atrioventricular block first degree 27.71 11.62 137 385926 5955 34564913
Pancreatitis 27.64 11.62 285 385778 38606 34532262
Dermatitis exfoliative generalised 27.62 11.62 97 385966 3610 34567258
Ear infection 27.50 11.62 44 386019 10187 34560681
Activated partial thromboplastin time prolonged 27.27 11.62 177 385886 8518 34562350
Hepatitis B reactivation 27.22 11.62 5 386058 3886 34566982
Cardiac valve disease 27.15 11.62 86 385977 3032 34567836
Nephrogenic anaemia 27.10 11.62 69 385994 2142 34568726
Psoriasis 26.94 11.62 286 385777 38526 34532342
Visual impairment 26.85 11.62 259 385804 35543 34535325
Bladder cancer 26.83 11.62 91 385972 16187 34554681
Electrocardiogram QT prolonged 26.63 11.62 616 385447 40336 34530532
Aspergillus infection 26.54 11.62 60 386003 12194 34558674
Ejection fraction abnormal 26.52 11.62 42 386021 915 34569953
Injection site bruising 26.50 11.62 34 386029 8629 34562239
Pericardial haemorrhage 26.50 11.62 86 385977 3072 34567796
Tachycardia 26.43 11.62 723 385340 84049 34486819
Mania 26.43 11.62 40 386023 9471 34561397
Priapism 26.42 11.62 11 386052 4983 34565885
Haemoptysis 26.42 11.62 538 385525 34468 34536400
Lipodystrophy acquired 26.40 11.62 3 386060 3341 34567527
Salivary hypersecretion 26.37 11.62 34 386029 8610 34562258
Blood pressure systolic decreased 26.27 11.62 109 385954 4394 34566474
Feeling abnormal 26.25 11.62 516 385547 62719 34508149
Neutropenic sepsis 26.23 11.62 72 385991 13695 34557173
Neurotoxicity 26.20 11.62 106 385957 17904 34552964
Hypomagnesaemia 26.14 11.62 362 385701 21489 34549379
Haemophagocytic lymphohistiocytosis 26.12 11.62 66 385997 12907 34557961
Renal artery stenosis 26.11 11.62 69 385994 2192 34568676
Dyskinesia 26.08 11.62 143 385920 22270 34548598
Hydrothorax 26.05 11.62 30 386033 475 34570393
Ventricular internal diameter abnormal 26.01 11.62 20 386043 183 34570685
Troponin T increased 26.01 11.62 71 385992 2300 34568568
Normochromic normocytic anaemia 25.98 11.62 105 385958 4182 34566686
Basal cell carcinoma 25.97 11.62 120 385943 19538 34551330
Cytomegalovirus infection reactivation 25.93 11.62 12 386051 5106 34565762
Enteritis 25.91 11.62 31 386032 8111 34562757
Dry mouth 25.80 11.62 211 385852 29954 34540914
Tardive dyskinesia 25.78 11.62 16 386047 5774 34565094
Hepatic cancer 25.68 11.62 168 385895 8107 34562761
Chronic hepatic failure 25.62 11.62 30 386033 484 34570384
Illness 25.60 11.62 71 385992 13458 34557410
Mood altered 25.51 11.62 37 386026 8915 34561953
Prerenal failure 25.50 11.62 65 385998 2019 34568849
Herpes zoster 25.31 11.62 250 385813 34149 34536719
Incorrect dose administered 25.20 11.62 306 385757 40209 34530659
Ventricular failure 25.18 11.62 16 386047 104 34570764
Pericardial effusion 24.97 11.62 397 385666 24265 34546603
Flushing 24.96 11.62 233 385830 32187 34538681
Mitral valve thickening 24.83 11.62 26 386037 368 34570500
Poisoning deliberate 24.82 11.62 30 386033 7814 34563054
Angina pectoris 24.67 11.62 485 385578 30878 34539990
Ventricular hypokinesia 24.65 11.62 124 385939 5428 34565440
Angina unstable 24.56 11.62 216 385847 11437 34559431
Cellulitis 24.53 11.62 762 385301 52189 34518679
Dysmorphism 24.50 11.62 3 386060 3153 34567715
Arteriospasm coronary 24.42 11.62 4 386059 3378 34567490
Epstein-Barr virus infection 24.32 11.62 29 386034 7599 34563269
Unevaluable event 24.31 11.62 500 385563 32090 34538778
Haemoconcentration 24.29 11.62 11 386052 31 34570837
Candida infection 24.08 11.62 107 385956 17608 34553260
Bone pain 24.06 11.62 132 385931 20554 34550314
Cytokine release syndrome 23.94 11.62 151 385912 22726 34548142
Anal fistula 23.93 11.62 15 386048 5384 34565484
Right ventricular dysfunction 23.91 11.62 45 386018 1131 34569737
Adverse drug reaction 23.85 11.62 208 385855 29134 34541734
Emotional disorder 23.83 11.62 17 386046 5699 34565169
Drug level decreased 23.79 11.62 31 386032 7815 34563053
Purpura 23.77 11.62 195 385868 10116 34560752
Hypersensitivity vasculitis 23.76 11.62 86 385977 3249 34567619
Occult blood positive 23.63 11.62 98 385965 3950 34566918
Superinfection 23.34 11.62 71 385992 2448 34568420
Hypercapnia 23.28 11.62 101 385962 4154 34566714
Dizziness 23.27 11.62 2755 383308 215766 34355102
Dilatation ventricular 23.22 11.62 73 385990 2563 34568305
Renal ischaemia 23.18 11.62 30 386033 539 34570329
Ventricular dysfunction 23.16 11.62 95 385968 3810 34567058
Exposure to toxic agent 23.12 11.62 6 386057 3669 34567199
Creatinine renal clearance decreased 23.09 11.62 86 385977 3295 34567573
Knee arthroplasty 23.00 11.62 29 386034 7415 34563453
Disease recurrence 22.93 11.62 141 385922 21349 34549519
Ventricular arrhythmia 22.83 11.62 121 385942 5407 34565461
Myalgia 22.81 11.62 731 385332 83379 34487489
Blood creatinine abnormal 22.75 11.62 68 385995 2322 34568546
Maternal exposure during pregnancy 22.73 11.62 13 386050 4905 34565963
Graft versus host disease 22.68 11.62 52 386011 10517 34560351
Microcytic anaemia 22.57 11.62 68 385995 2332 34568536
Influenza 22.56 11.62 399 385664 49267 34521601
Ischaemic stroke 22.50 11.62 304 385759 17946 34552922
Psychiatric decompensation 22.30 11.62 3 386060 2934 34567934
Bronchopulmonary aspergillosis 22.14 11.62 85 385978 14574 34556294
Aortic valve stenosis 22.13 11.62 73 385990 2630 34568238
Inflammatory bowel disease 22.13 11.62 3 386060 2917 34567951
Tendonitis 22.12 11.62 42 386021 9098 34561770
Device leakage 22.05 11.62 24 386039 6551 34564317
Varices oesophageal 21.99 11.62 91 385972 3664 34567204
Pseudoporphyria 21.94 11.62 24 386039 358 34570510
Hyponatraemic syndrome 21.89 11.62 18 386045 183 34570685
Blood pressure diastolic abnormal 21.89 11.62 13 386050 4805 34566063
Small for dates baby 21.85 11.62 8 386055 3919 34566949
Graft versus host disease in skin 21.83 11.62 8 386055 3917 34566951
Feeling hot 21.78 11.62 125 385938 19247 34551621
Dermatitis bullous 21.77 11.62 141 385922 6781 34564087
Hand deformity 21.74 11.62 7 386056 3718 34567150
Oropharyngeal pain 21.70 11.62 269 385794 35216 34535652
Musculoskeletal pain 21.59 11.62 237 385826 31726 34539142
Neuromyopathy 21.56 11.62 40 386023 994 34569874
Multiple sclerosis 21.47 11.62 25 386038 6620 34564248
Injection site mass 21.33 11.62 25 386038 6601 34564267
Suspected suicide 21.31 11.62 13 386050 4735 34566133
Gouty tophus 21.29 11.62 16 386047 141 34570727
Blood cholesterol increased 21.29 11.62 136 385927 20407 34550461
Anticoagulation drug level increased 21.27 11.62 28 386035 512 34570356
Mood swings 21.22 11.62 34 386029 7867 34563001
Ammonia increased 21.13 11.62 100 385963 4269 34566599
Eye pain 21.02 11.62 77 385986 13385 34557483
Apparent death 21.00 11.62 7 386056 3637 34567231
Coma hepatic 20.86 11.62 26 386037 449 34570419
Hypoalbuminaemia 20.86 11.62 216 385847 11958 34558910
Cataract 20.68 11.62 187 385876 25999 34544869
Lymphoma 20.56 11.62 70 385993 12437 34558431
Alcohol poisoning 20.54 11.62 7 386056 3586 34567282
Eyelid ptosis 20.52 11.62 20 386043 5746 34565122
Status epilepticus 20.46 11.62 71 385992 12543 34558325
Myasthenia gravis 20.45 11.62 28 386035 6912 34563956
Eye pruritus 20.33 11.62 32 386031 7457 34563411
BK virus infection 20.31 11.62 20 386043 5718 34565150
Unintentional medical device removal 20.29 11.62 3 386060 2733 34568135
Vascular graft 20.24 11.62 49 386014 1473 34569395
Viral mutation identified 20.23 11.62 4 386059 2950 34567918
Drug-induced liver injury 20.20 11.62 212 385851 28620 34542248
Pneumocystis jirovecii pneumonia 20.16 11.62 131 385932 19579 34551289
Central nervous system lesion 20.15 11.62 25 386038 6438 34564430
Cerebral haemorrhage 20.15 11.62 517 385546 34420 34536448
Muscle haemorrhage 20.14 11.62 88 385975 3630 34567238
Hypogammaglobulinaemia 20.14 11.62 34 386029 7706 34563162
Respiratory distress 20.05 11.62 526 385537 35139 34535729
Neck pain 20.03 11.62 181 385882 25168 34545700
Intraocular pressure increased 19.95 11.62 18 386045 5365 34565503
Increased appetite 19.92 11.62 32 386031 7397 34563471
Facial pain 19.85 11.62 8 386055 3696 34567172
Lower gastrointestinal haemorrhage 19.81 11.62 175 385888 9277 34561591
Hypercreatininaemia 19.77 11.62 26 386037 475 34570393
Rash maculo-papular 19.76 11.62 432 385631 28019 34542849
Fistula 19.76 11.62 28 386035 6812 34564056
Long QT syndrome 19.73 11.62 72 385991 2731 34568137
Posthaemorrhagic hydrocephalus 19.71 11.62 14 386049 112 34570756
International normalised ratio abnormal 19.67 11.62 81 385982 3254 34567614
Graft versus host disease in gastrointestinal tract 19.67 11.62 8 386055 3675 34567193
Mental impairment 19.65 11.62 54 386009 10268 34560600
Chronic graft versus host disease 19.59 11.62 12 386051 4361 34566507
Drug specific antibody present 19.48 11.62 6 386057 3279 34567589
Blood bilirubin increased 19.33 11.62 557 385506 37739 34533129
Depressive symptom 19.31 11.62 4 386059 2855 34568013
Second primary malignancy 19.29 11.62 36 386027 7850 34563018
Pulmonary function test abnormal 19.19 11.62 68 385995 2542 34568326
Right atrial hypertrophy 19.17 11.62 33 386030 772 34570096
Gastrointestinal vascular malformation haemorrhagic 19.11 11.62 29 386034 608 34570260
Hepatic enzyme increased 19.03 11.62 310 385753 38770 34532098
Maternal drugs affecting foetus 19.02 11.62 10 386053 3955 34566913
Head injury 19.02 11.62 294 385769 17866 34553002
Throat irritation 18.96 11.62 57 386006 10528 34560340
Disinhibition 18.94 11.62 6 386057 3220 34567648
Asterixis 18.92 11.62 42 386021 1191 34569677
Meningitis aseptic 18.92 11.62 6 386057 3218 34567650
Blindness 18.91 11.62 93 385970 14893 34555975
Abscess 18.84 11.62 67 385996 11750 34559118
Drug screen positive 18.84 11.62 10 386053 3933 34566935
Premature baby 18.83 11.62 133 385930 19500 34551368
Atrial septal defect 18.75 11.62 33 386030 7359 34563509
Nephrocalcinosis 18.74 11.62 29 386034 619 34570249
Photophobia 18.67 11.62 30 386033 6934 34563934
Spontaneous haematoma 18.55 11.62 26 386037 506 34570362
Dependence on oxygen therapy 18.44 11.62 17 386046 204 34570664
Grip strength decreased 18.42 11.62 6 386057 3163 34567705
Crepitations 18.36 11.62 77 385986 3119 34567749
Alcohol abuse 18.21 11.62 15 386048 4675 34566193
Pulmonary arterial pressure increased 18.20 11.62 42 386021 1223 34569645
Delayed graft function 18.20 11.62 60 386003 2161 34568707
Cardio-respiratory distress 18.04 11.62 14 386049 130 34570738
Arteriosclerosis 18.04 11.62 207 385856 11761 34559107
International normalised ratio fluctuation 18.00 11.62 42 386021 1232 34569636
Peripheral vascular disorder 17.99 11.62 106 385957 4930 34565938
Amyloidosis 17.98 11.62 58 386005 2065 34568803
Disease progression 17.94 11.62 993 385070 107084 34463784
Encephalopathy 17.90 11.62 514 385549 34805 34536063
Obsessive-compulsive disorder 17.90 11.62 21 386042 5543 34565325
Strongyloidiasis 17.89 11.62 4 386059 2707 34568161
Alcohol interaction 17.86 11.62 5 386058 2908 34567960
Sudden death 17.84 11.62 251 385812 14950 34555918
Road traffic accident 17.84 11.62 116 385947 17334 34553534
Leukopenia 17.84 11.62 543 385520 62313 34508555
Left ventricle outflow tract obstruction 17.82 11.62 15 386048 158 34570710
Dermatitis exfoliative 17.78 11.62 130 385933 6509 34564359
Hepatitis B 17.77 11.62 24 386039 5959 34564909
Ventricular dyssynchrony 17.76 11.62 7 386056 12 34570856
Blood sodium decreased 17.75 11.62 265 385798 15986 34554882
Base excess increased 17.65 11.62 10 386053 51 34570817
Epilepsy 17.63 11.62 152 385911 21343 34549525
Viral infection 17.59 11.62 118 385945 17505 34553363
Posterior reversible encephalopathy syndrome 17.55 11.62 54 386009 9900 34560968
Gastritis erosive 17.55 11.62 119 385944 5813 34565055
Dermatitis atopic 17.40 11.62 20 386043 5327 34565541
Weight decreased 17.29 11.62 1694 384369 174607 34396261
Cerebrovascular accident 17.28 11.62 1122 384941 83689 34487179
Tension headache 17.26 11.62 6 386057 3036 34567832
Urinary tract discomfort 17.26 11.62 13 386050 115 34570753
Prohormone brain natriuretic peptide increased 17.25 11.62 11 386052 72 34570796
Catatonia 17.23 11.62 18 386045 5007 34565861
Peripheral venous disease 17.23 11.62 67 385996 2621 34568247
Faeces discoloured 17.20 11.62 245 385818 14633 34556235
Upper respiratory tract infection 17.19 11.62 259 385804 32800 34538068
Narrow anterior chamber angle 17.17 11.62 13 386050 116 34570752
Gastrointestinal angiodysplasia 17.12 11.62 27 386036 586 34570282
Upper motor neurone lesion 17.08 11.62 13 386050 117 34570751
Medication error 17.07 11.62 386 385677 25179 34545689
Post procedural haematoma 17.04 11.62 46 386017 1480 34569388
Diabetic nephropathy 17.00 11.62 57 386006 2071 34568797
Ejection fraction 17.00 11.62 12 386051 95 34570773
Tuberculosis 16.99 11.62 44 386019 8533 34562335
Oropharyngeal discomfort 16.97 11.62 7 386056 3189 34567679
Ecchymosis 16.97 11.62 131 385932 6672 34564196
Mitral valve calcification 16.93 11.62 26 386037 551 34570317
Crying 16.93 11.62 24 386039 5838 34565030
Plasma cell myeloma 16.91 11.62 595 385468 41442 34529426
Polyneuropathy 16.81 11.62 96 385967 14800 34556068
Coronary arterial stent insertion 16.79 11.62 90 385973 4039 34566829
Aspiration pleural cavity 16.79 11.62 32 386031 812 34570056
Renal artery thrombosis 16.74 11.62 19 386044 296 34570572
Anosmia 16.73 11.62 12 386051 4012 34566856
Device use error 16.73 11.62 3 386060 2372 34568496
Hypoperfusion 16.72 11.62 39 386024 1144 34569724
Diabetic foot 16.67 11.62 68 385995 2720 34568148
Multimorbidity 16.67 11.62 34 386029 908 34569960
Impaired quality of life 16.62 11.62 24 386039 5794 34565074
Skin toxicity 16.56 11.62 17 386046 4767 34566101
Atrial thrombosis 16.55 11.62 58 386005 2156 34568712
Lung disorder 16.52 11.62 501 385562 34195 34536673
Osmotic demyelination syndrome 16.50 11.62 32 386031 823 34570045
Base excess decreased 16.47 11.62 16 386047 206 34570662
Ischaemic hepatitis 16.45 11.62 51 386012 1777 34569091
Hypochromasia 16.44 11.62 19 386044 302 34570566
Squamous cell carcinoma 16.40 11.62 68 385995 11407 34559461
Antipsychotic drug level below therapeutic 16.33 11.62 4 386059 2543 34568325
Tachyarrhythmia 16.31 11.62 81 385982 3527 34567341
Faecal calprotectin increased 16.30 11.62 4 386059 2540 34568328
Product substitution issue 16.25 11.62 57 386006 10038 34560830
Acquired macroglossia 16.18 11.62 7 386056 17 34570851
Mitral valve replacement 16.14 11.62 15 386048 182 34570686
Injection site pruritus 16.11 11.62 33 386030 6950 34563918
Paracentesis 16.08 11.62 22 386041 418 34570450
Hyperthyroidism 16.04 11.62 183 385880 10383 34560485
Diffuse large B-cell lymphoma 16.03 11.62 36 386027 7334 34563534
Right atrial enlargement 15.94 11.62 17 386046 246 34570622
Diverticulum intestinal 15.92 11.62 87 385976 3934 34566934
Right ventricular hypertrophy 15.90 11.62 45 386018 1489 34569379
Respiratory arrest 15.88 11.62 216 385847 27827 34543041
Gastric ulcer 15.87 11.62 252 385811 15398 34555470
Cytomegalovirus chorioretinitis 15.87 11.62 10 386053 3579 34567289
Brain natriuretic peptide abnormal 15.85 11.62 20 386043 350 34570518
Middle insomnia 15.82 11.62 32 386031 6770 34564098
Apathy 15.79 11.62 33 386030 6899 34563969
Anaphylactic shock 15.78 11.62 107 385956 15834 34555034
Adenovirus infection 15.71 11.62 21 386042 5236 34565632
Fabry's disease 15.70 11.62 6 386057 9 34570859
Abdominal wall haemorrhage 15.69 11.62 23 386040 467 34570401
Malignant melanoma 15.65 11.62 42 386021 8048 34562820
Gouty arthritis 15.56 11.62 36 386027 1050 34569818
Intraductal papillary mucinous neoplasm 15.55 11.62 24 386039 511 34570357
Sinus node dysfunction 15.54 11.62 90 385973 4159 34566709
Accidental death 15.47 11.62 4 386059 2452 34568416
Thymus hypoplasia 15.43 11.62 21 386042 397 34570471
Lymphoid tissue hypoplasia 15.43 11.62 21 386042 397 34570471
Nephrogenic systemic fibrosis 15.42 11.62 86 385977 3919 34566949
Confusional state 15.39 11.62 1818 384245 142342 34428526
Atrial enlargement 15.29 11.62 27 386036 645 34570223
Tongue disorder 15.28 11.62 22 386041 5317 34565551
Pulmonary tuberculosis 15.24 11.62 18 386045 4736 34566132
C-reactive protein increased 15.19 11.62 468 385595 53630 34517238
Skin lesion 15.17 11.62 162 385901 21799 34549069
Cardioactive drug level decreased 15.15 11.62 10 386053 70 34570798
Product quality issue 15.10 11.62 118 385945 16917 34553951
Renal cancer 15.08 11.62 40 386023 7695 34563173
Ventricular dyskinesia 15.03 11.62 16 386047 231 34570637
Virologic failure 14.97 11.62 10 386053 3470 34567398
Impaired work ability 14.95 11.62 34 386029 6896 34563972
Drug abuser 14.92 11.62 13 386050 3941 34566927
Abnormal dreams 14.91 11.62 39 386024 7539 34563329
Osteonecrosis of jaw 14.90 11.62 126 385937 17763 34553105
Tooth infection 14.79 11.62 33 386030 6738 34564130
Hypertriglyceridaemia 14.77 11.62 46 386017 8402 34562466
Pulmonary vein stenosis 14.73 11.62 8 386055 37 34570831
Social avoidant behaviour 14.73 11.62 8 386055 3106 34567762
Mycobacterial infection 14.70 11.62 4 386059 2370 34568498
Neuralgia 14.68 11.62 102 385961 15011 34555857
Urine calcium decreased 14.64 11.62 6 386057 12 34570856
Attention deficit hyperactivity disorder 14.60 11.62 5 386058 2554 34568314
Hepatic steatosis 14.55 11.62 131 385932 18231 34552637
Loss of libido 14.54 11.62 5 386058 2547 34568321
Gastritis haemorrhagic 14.49 11.62 42 386021 1409 34569459
Blood bicarbonate increased 14.49 11.62 23 386040 502 34570366
Delusion 14.49 11.62 81 385982 12554 34558314
Cholestasis 14.45 11.62 395 385668 26553 34544315
Nocturnal dyspnoea 14.45 11.62 24 386039 545 34570323
Heart sounds abnormal 14.44 11.62 31 386032 859 34570009
Sinus arrhythmia 14.39 11.62 30 386033 814 34570054
Mumps 14.39 11.62 10 386053 77 34570791
Melanoderma 14.37 11.62 13 386050 152 34570716
Gastric varices 14.35 11.62 24 386039 548 34570320
Neonatal respiratory distress syndrome 14.35 11.62 14 386049 4020 34566848
Drug level below therapeutic 14.30 11.62 25 386038 5590 34565278
Coagulation time prolonged 14.29 11.62 39 386024 1263 34569605
Dyspepsia 14.27 11.62 303 385760 36429 34534439
Antipsychotic drug level increased 14.23 11.62 13 386050 3852 34567016
Haematocrit decreased 14.23 11.62 461 385602 31755 34539113
Wrong technique in product usage process 14.22 11.62 296 385767 35690 34535178
Right atrial dilatation 14.22 11.62 18 386045 316 34570552
Rectal prolapse 14.20 11.62 22 386041 470 34570398
Toxic skin eruption 14.18 11.62 190 385873 11195 34559673
Sleep terror 14.18 11.62 4 386059 2314 34568554
Dry eye 14.15 11.62 56 386007 9519 34561349
Mitral valve disease 14.10 11.62 41 386022 1378 34569490
Hypertensive cardiomyopathy 14.10 11.62 13 386050 156 34570712
Heparin-induced thrombocytopenia 14.10 11.62 108 385955 5487 34565381
Tongue oedema 14.06 11.62 68 385995 2929 34567939
Abdominal cavity drainage 14.05 11.62 20 386043 395 34570473
Portopulmonary hypertension 14.03 11.62 6 386057 14 34570854
Phlebitis deep 14.03 11.62 6 386057 14 34570854
Glomerular filtration rate 14.02 11.62 11 386052 104 34570764
Bronchial secretion retention 13.96 11.62 43 386020 1493 34569375
Pulmonary arterial wedge pressure increased 13.93 11.62 11 386052 105 34570763
Red blood cell sedimentation rate increased 13.92 11.62 53 386010 9109 34561759
Dizziness postural 13.90 11.62 116 385947 6048 34564820
Ventricular flutter 13.88 11.62 10 386053 82 34570786
Prostate cancer stage II 13.83 11.62 4 386059 2277 34568591
Movement disorder 13.78 11.62 79 385984 12169 34558699
Speech disorder 13.78 11.62 200 385863 25486 34545382
Anticoagulation drug level above therapeutic 13.77 11.62 53 386010 2063 34568805
Dysphagia 13.76 11.62 556 385507 61825 34509043
Renal cyst haemorrhage 13.68 11.62 25 386038 614 34570254
Anaemia folate deficiency 13.66 11.62 7 386056 28 34570840
Alveolar lung disease 13.66 11.62 19 386044 367 34570501
Coagulopathy 13.59 11.62 300 385763 19489 34551379
Surgery 13.53 11.62 96 385967 14061 34556807
Circulatory collapse 13.53 11.62 316 385747 20722 34550146
Hypochloraemia 13.51 11.62 25 386038 620 34570248
Jaundice 13.51 11.62 454 385609 31428 34539440
Device pacing issue 13.51 11.62 8 386055 45 34570823
Implantable defibrillator insertion 13.50 11.62 28 386035 757 34570111
Peripheral arterial occlusive disease 13.49 11.62 111 385952 5763 34565105
Nodule 13.49 11.62 35 386028 6784 34564084
Restlessness 13.47 11.62 199 385864 25283 34545585
Aortic dilatation 13.47 11.62 40 386023 1361 34569507
Cardiac ablation 13.38 11.62 34 386029 1054 34569814
Ocular hyperaemia 13.36 11.62 73 385990 11379 34559489
Drug effective for unapproved indication 13.34 11.62 6 386057 2596 34568272
Rheumatoid nodule 13.32 11.62 8 386055 2939 34567929
Hypertensive emergency 13.32 11.62 33 386030 1007 34569861
Transaminases increased 13.32 11.62 212 385851 26611 34544257
Visual field defect 13.30 11.62 18 386045 4465 34566403
Osteonecrosis 13.26 11.62 103 385960 14787 34556081
Partial seizures 13.24 11.62 20 386043 4740 34566128
Therapy non-responder 13.21 11.62 330 385733 38816 34532052
Agonal rhythm 13.19 11.62 9 386054 67 34570801
Lymphoproliferative disorder 13.18 11.62 7 386056 2752 34568116
Mobility decreased 13.06 11.62 244 385819 29884 34540984
Injection site rash 13.02 11.62 16 386047 4137 34566731
Intervertebral disc protrusion 13.02 11.62 61 386002 9895 34560973
Agranulocytosis 13.01 11.62 350 385713 23471 34547397
Bone marrow failure 12.97 11.62 236 385827 29017 34541851
Gastrointestinal arteriovenous malformation 12.93 11.62 18 386045 348 34570520
Cardiac tamponade 12.91 11.62 101 385962 5165 34565703
Acquired haemophilia 12.88 11.62 32 386031 978 34569890
Pericardial drainage 12.88 11.62 10 386053 93 34570775
Liver function test increased 12.86 11.62 101 385962 14464 34556404
Nephrosclerosis 12.84 11.62 31 386032 930 34569938
Papilloedema 12.79 11.62 7 386056 2706 34568162
Right ventricular systolic pressure decreased 12.75 11.62 6 386057 19 34570849
Pseudo-Bartter syndrome 12.75 11.62 6 386057 19 34570849
Bipolar disorder 12.74 11.62 13 386050 3656 34567212
Nocardiosis 12.62 11.62 15 386048 3936 34566932
Chronic left ventricular failure 12.61 11.62 23 386040 564 34570304
Scrotal swelling 12.60 11.62 40 386023 1412 34569456
Brain oedema 12.59 11.62 95 385968 13726 34557142
Uraemic encephalopathy 12.59 11.62 17 386046 319 34570549
Adult failure to thrive 12.54 11.62 5 386058 9 34570859
Depression suicidal 12.50 11.62 6 386057 2499 34568369
Cardiac resynchronisation therapy 12.46 11.62 7 386056 35 34570833
Lividity 12.44 11.62 12 386051 153 34570715
Behaviour disorder 12.38 11.62 22 386041 4888 34565980
Tendon pain 12.36 11.62 9 386054 2986 34567882
Bradypnoea 12.35 11.62 8 386055 2821 34568047
Normocytic anaemia 12.34 11.62 55 386008 2289 34568579
Erysipelas 12.33 11.62 94 385969 4769 34566099
Cardioversion 12.32 11.62 30 386033 905 34569963
Osteolysis 12.31 11.62 10 386053 3138 34567730
Cytopenia 12.30 11.62 86 385977 12637 34558231
Chest X-ray abnormal 12.28 11.62 87 385976 4311 34566557
Hypovolaemic shock 12.28 11.62 126 385937 6959 34563909
Oesophageal perforation 12.26 11.62 35 386028 1164 34569704
Hepatic function abnormal 12.16 11.62 603 385460 43760 34527108
Hypophysitis 12.15 11.62 5 386058 2281 34568587
Degenerative aortic valve disease 12.10 11.62 6 386057 22 34570846
Oesophageal variceal ligation 12.10 11.62 9 386054 78 34570790
Crohn's disease 12.06 11.62 10 386053 3107 34567761
Strangury 12.06 11.62 11 386052 130 34570738
Haemorrhagic arteriovenous malformation 12.05 11.62 18 386045 372 34570496
Aplastic anaemia 12.04 11.62 162 385901 9554 34561314
Kidney small 12.01 11.62 8 386055 57 34570811
Femoral artery aneurysm 11.96 11.62 12 386051 161 34570707
Pulmonary hypertensive crisis 11.96 11.62 12 386051 161 34570707
Peritoneal cloudy effluent 11.96 11.62 12 386051 161 34570707
Cardio-respiratory arrest 11.94 11.62 735 385328 54538 34516330
Metastases to liver 11.94 11.62 95 385968 13568 34557300
Injection site urticaria 11.91 11.62 4 386059 2068 34568800
Subarachnoid haemorrhage 11.90 11.62 201 385862 12434 34558434
Enteropathy-associated T-cell lymphoma 11.86 11.62 4 386059 3 34570865
Muscle spasticity 11.82 11.62 30 386033 5858 34565010
Blood urea abnormal 11.82 11.62 27 386036 781 34570087
Intestinal obstruction 11.79 11.62 179 385884 22643 34548225
Discomfort 11.79 11.62 143 385920 18795 34552073
Bundle branch block right 11.78 11.62 131 385932 7385 34563483
Thinking abnormal 11.76 11.62 32 386031 6105 34564763
Muscle rigidity 11.75 11.62 68 385995 10450 34560418
Electrocardiogram T wave peaked 11.74 11.62 23 386040 596 34570272
Left ventricular end-diastolic pressure increased 11.73 11.62 13 386050 197 34570671
Cutaneous vasculitis 11.72 11.62 84 385979 4179 34566689
Glomerular filtration rate abnormal 11.71 11.62 28 386035 835 34570033
Pulmonary mass 11.71 11.62 88 385975 12724 34558144
Euglycaemic diabetic ketoacidosis 11.67 11.62 11 386052 3211 34567657
Soft tissue mass 11.67 11.62 31 386032 988 34569880
Cryptorchism 11.63 11.62 4 386059 2037 34568831

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 5051.68 10.43 13448 741155 505956 78483829
Cardiac failure congestive 3981.00 10.43 5769 748834 136633 78853152
Cardiac failure 2594.66 10.43 4987 749616 149855 78839930
Hyperkalaemia 2419.19 10.43 4078 750525 110320 78879465
Drug ineffective 2046.39 10.43 4511 750092 1076402 77913383
Hypotension 1372.19 10.43 7965 746638 432352 78557433
Renal failure 1335.32 10.43 4561 750042 196407 78793378
Off label use 1190.63 10.43 4498 750105 902717 78087068
International normalised ratio increased 1177.82 10.43 2527 752076 82194 78907591
Oedema peripheral 1165.73 10.43 5103 749500 247185 78742600
Hyponatraemia 1132.20 10.43 3980 750623 173868 78815917
Atrial fibrillation 1003.16 10.43 4118 750485 193768 78796017
Dyspnoea 981.02 10.43 12385 742218 844640 78145145
Hypokalaemia 973.70 10.43 3289 751314 140751 78849034
Drug intolerance 896.63 10.43 711 753892 263408 78726377
Hand deformity 882.20 10.43 21 754582 103898 78885887
Drug interaction 859.75 10.43 6791 747812 408392 78581393
Pemphigus 845.83 10.43 20 754583 99562 78890223
Synovitis 838.39 10.43 198 754405 150536 78839249
Arthropathy 827.32 10.43 320 754283 176791 78812994
Completed suicide 811.27 10.43 680 753923 245087 78744698
Arthralgia 781.43 10.43 2784 751819 569019 78420766
Infusion related reaction 778.59 10.43 622 753981 229615 78760170
Therapeutic product effect decreased 762.15 10.43 298 754305 163565 78826220
Rheumatoid arthritis 750.15 10.43 528 754075 207942 78781843
Bradycardia 747.59 10.43 2897 751706 132660 78857125
Alopecia 741.83 10.43 658 753945 230697 78759088
Treatment failure 737.18 10.43 345 754258 170141 78819644
Blood creatinine increased 715.82 10.43 3137 751466 151920 78837865
Glossodynia 698.12 10.43 80 754523 103257 78886528
Anaemia 696.01 10.43 6845 747758 438170 78551615
Renal impairment 695.84 10.43 3149 751454 154634 78835151
Pulmonary hypertension 668.98 10.43 1435 753168 46645 78943140
Joint swelling 644.64 10.43 1087 753516 287559 78702226
Melaena 637.80 10.43 1626 752977 59264 78930521
Dehydration 631.29 10.43 4266 750337 243921 78745864
Fall 620.84 10.43 7197 747406 480432 78509353
Drug hypersensitivity 612.64 10.43 1187 753416 297729 78692056
Systemic lupus erythematosus 599.54 10.43 199 754404 120950 78868835
Blood urea increased 594.37 10.43 1381 753222 47409 78942376
Maternal exposure during pregnancy 593.79 10.43 274 754329 136264 78853521
Fluid retention 587.29 10.43 1720 752883 68089 78921696
Hypersensitivity 586.03 10.43 987 753616 261252 78728533
Contraindicated product administered 585.35 10.43 385 754218 157153 78832632
Drug abuse 582.62 10.43 414 754189 162277 78827508
Pulmonary arterial hypertension 569.56 10.43 989 753614 27377 78962408
Pericarditis 563.82 10.43 145 754458 104091 78885694
Myocardial infarction 562.55 10.43 3317 751286 180812 78808973
Musculoskeletal stiffness 559.35 10.43 499 754104 174509 78815276
Gastrointestinal haemorrhage 551.97 10.43 2811 751792 144908 78844877
Orthostatic hypotension 546.43 10.43 1459 753144 54705 78935080
Syncope 539.40 10.43 3219 751384 176230 78813555
Duodenal ulcer perforation 537.89 10.43 20 754583 66191 78923594
Rheumatoid factor positive 533.17 10.43 6 754597 59833 78929952
Pain 522.11 10.43 4212 750391 699590 78290195
Cardiac failure chronic 513.04 10.43 579 754024 10556 78979229
Abdominal discomfort 486.00 10.43 1028 753575 249699 78740086
Hypoglycaemia 485.16 10.43 2077 752526 99517 78890268
Oedema 465.31 10.43 2302 752301 117278 78872507
Lactic acidosis 454.39 10.43 1583 753020 68776 78921009
Helicobacter infection 453.61 10.43 61 754542 69643 78920142
Discomfort 453.21 10.43 317 754286 125300 78864485
Right ventricular failure 450.72 10.43 803 753800 22694 78967091
Hypervolaemia 447.02 10.43 1140 753463 41550 78948235
Pulmonary oedema 444.54 10.43 1834 752769 86420 78903365
Hepatic enzyme increased 422.06 10.43 672 753931 181938 78807847
Hepatic encephalopathy 419.51 10.43 791 753812 23375 78966410
Sinusitis 413.77 10.43 761 753842 194740 78795045
Product use issue 410.99 10.43 855 753748 208967 78780818
Chronic kidney disease 410.51 10.43 1469 753134 64685 78925100
Pleural effusion 408.10 10.43 2561 752042 142701 78847084
Intentional product use issue 401.85 10.43 509 754094 151603 78838182
Rash 398.79 10.43 3527 751076 574831 78414954
Nasopharyngitis 391.65 10.43 1170 753433 252711 78737074
Psoriatic arthropathy 389.60 10.43 126 754477 77873 78911912
Folliculitis 383.88 10.43 39 754564 55341 78934444
Therapeutic product effect incomplete 379.37 10.43 469 754134 141176 78848609
Wound 372.64 10.43 330 754273 115849 78873936
Sleep disorder due to general medical condition, insomnia type 361.41 10.43 11 754592 43545 78946240
Muscle injury 358.97 10.43 26 754577 48535 78941250
Ascites 348.58 10.43 1529 753074 74033 78915752
Product use in unapproved indication 338.32 10.43 1223 753380 249136 78740649
Injection site pain 336.19 10.43 441 754162 129397 78860388
Intentional overdose 329.10 10.43 310 754293 105650 78884135
Irritable bowel syndrome 313.59 10.43 99 754504 62142 78927643
Metabolic alkalosis 303.83 10.43 287 754316 4202 78985583
Injection site erythema 298.71 10.43 185 754418 78012 78911773
Ventricular tachycardia 295.83 10.43 972 753631 40963 78948822
Torsade de pointes 294.97 10.43 599 754004 18713 78971072
Cardiac failure acute 294.94 10.43 592 754011 18337 78971448
Suicide attempt 292.91 10.43 214 754389 82718 78907067
Coronary artery disease 290.76 10.43 1310 753293 64164 78925621
Headache 282.11 10.43 4421 750182 649351 78340434
Injection site reaction 269.21 10.43 91 754512 54694 78935091
Respiratory failure 268.48 10.43 2755 751848 178156 78811629
Fatigue 258.40 10.43 6764 747839 922963 78066822
Dyspnoea exertional 258.19 10.43 1557 753046 85516 78904269
Gastrointestinal disorder 255.53 10.43 479 754124 121726 78868059
Orthopnoea 254.86 10.43 390 754213 9683 78980102
Rhabdomyolysis 254.19 10.43 1760 752843 101371 78888414
Rectal haemorrhage 250.04 10.43 1401 753202 74899 78914886
Haematoma 245.91 10.43 1063 753540 51132 78938653
Rheumatic fever 245.03 10.43 5 754598 28520 78961265
N-terminal prohormone brain natriuretic peptide increased 244.61 10.43 262 754341 4493 78985292
Toxicity to various agents 243.42 10.43 2682 751921 418858 78570927
Infection 238.41 10.43 1327 753276 240385 78749400
Hypovolaemia 238.00 10.43 521 754082 17170 78972615
Urticaria 236.88 10.43 925 753678 184276 78805509
Stomatitis 235.14 10.43 664 753939 146093 78843692
Mitral valve incompetence 234.60 10.43 698 753905 27867 78961918
Generalised oedema 232.66 10.43 618 753985 23091 78966694
Acute myocardial infarction 232.53 10.43 1384 753219 75652 78914133
Chronic obstructive pulmonary disease 232.34 10.43 1494 753109 83925 78905860
C-reactive protein abnormal 226.33 10.43 87 754516 48280 78941505
Impaired healing 225.57 10.43 299 754304 87356 78902429
Cardioactive drug level increased 218.93 10.43 220 754383 3489 78986296
Haemoglobin decreased 218.56 10.43 3129 751474 218990 78770795
Creatinine renal clearance decreased 216.35 10.43 524 754079 18478 78971307
Exposure during pregnancy 210.89 10.43 397 754206 100735 78889050
Nausea 210.87 10.43 7185 747418 950011 78039774
Shock haemorrhagic 210.29 10.43 536 754067 19524 78970261
Blood potassium increased 207.77 10.43 680 753923 28595 78961190
Cardiomegaly 207.07 10.43 634 753969 25718 78964067
Urine output decreased 203.08 10.43 495 754108 17527 78972258
Injection site swelling 196.56 10.43 100 754503 47032 78942753
Pneumonia 194.33 10.43 7862 746741 652384 78337401
Electrocardiogram QT prolonged 193.19 10.43 1491 753112 88895 78900890
Swelling 188.34 10.43 1238 753365 215473 78774312
Ill-defined disorder 187.18 10.43 208 754395 65667 78924118
Hepatic failure 184.91 10.43 1100 753503 60112 78929673
Brain natriuretic peptide increased 184.79 10.43 315 754288 8585 78981200
Hypernatraemia 184.74 10.43 417 754186 14034 78975751
Sopor 184.62 10.43 709 753894 32301 78957484
Renal injury 183.41 10.43 458 754145 16469 78973316
Gout 182.99 10.43 583 754020 24166 78965619
Presyncope 182.69 10.43 822 753781 40232 78949553
Device expulsion 179.78 10.43 18 754585 25843 78963942
COVID-19 179.70 10.43 823 753780 156851 78832934
Abortion spontaneous 177.94 10.43 32 754571 29475 78960310
Red blood cell sedimentation rate increased 177.81 10.43 107 754496 45835 78943950
Suicidal ideation 176.20 10.43 281 754322 76059 78913726
Blood pressure decreased 172.73 10.43 1566 753037 97900 78891885
Red blood cell sedimentation rate abnormal 171.40 10.43 6 754597 20957 78968828
Anuria 170.02 10.43 510 754093 20453 78969332
Ejection fraction decreased 165.02 10.43 707 753896 33870 78955915
Hypoxia 164.05 10.43 1595 753008 101648 78888137
Injection site pruritus 161.52 10.43 100 754503 42183 78947602
Sleep disorder 161.06 10.43 357 754246 85320 78904465
Asthenia 160.88 10.43 6138 748465 505551 78484234
Hypoaesthesia 159.15 10.43 1018 753585 178334 78811451
Epistaxis 158.61 10.43 1684 752919 109831 78879954
Death 157.86 10.43 6708 747895 559806 78429979
Hip arthroplasty 156.54 10.43 71 754532 35685 78954100
Cardiac disorder 156.01 10.43 1112 753491 64645 78925140
Intentional product misuse 155.05 10.43 427 754176 94738 78895047
Ischaemic cardiomyopathy 154.06 10.43 268 754335 7427 78982358
Paraesthesia 153.82 10.43 1006 753597 175317 78814468
Hypocalcaemia 153.26 10.43 901 753702 49023 78940762
Transfusion 152.75 10.43 497 754106 20833 78968952
Febrile neutropenia 152.45 10.43 1423 753180 229576 78760209
Knee arthroplasty 152.17 10.43 112 754491 43136 78946649
Rales 150.48 10.43 474 754129 19527 78970258
Multiple organ dysfunction syndrome 150.16 10.43 1770 752833 118476 78871309
Acute pulmonary oedema 149.97 10.43 381 754222 13849 78975936
Drug ineffective for unapproved indication 149.77 10.43 158 754445 51080 78938705
Tricuspid valve incompetence 147.25 10.43 466 754137 19246 78970539
Multiple sclerosis relapse 146.98 10.43 134 754469 46399 78943386
Glomerular filtration rate decreased 144.10 10.43 508 754095 22194 78967591
Pregnancy 143.91 10.43 38 754565 26813 78962972
Neutropenia 140.98 10.43 1896 752707 285814 78703971
Night sweats 140.98 10.43 171 754432 51924 78937861
Atrioventricular block 140.82 10.43 369 754234 13672 78976113
Blood potassium decreased 140.58 10.43 836 753767 45676 78944109
Inappropriate schedule of product administration 139.77 10.43 719 753884 132909 78856876
Toxic epidermal necrolysis 139.72 10.43 809 753794 43772 78946013
Injection site bruising 139.39 10.43 110 754493 40892 78948893
Congestive cardiomyopathy 138.58 10.43 329 754274 11451 78978334
Hypomagnesaemia 137.21 10.43 836 753767 46075 78943710
Subdural haematoma 136.58 10.43 625 753978 30809 78958976
Fibromyalgia 136.40 10.43 250 754353 64090 78925695
Acute respiratory failure 136.13 10.43 998 753605 58543 78931242
Pyrexia 135.96 10.43 5152 749451 673557 78316228
Blood cholesterol increased 134.64 10.43 378 754225 83342 78906443
Loss of personal independence in daily activities 133.24 10.43 509 754094 102071 78887714
Cardiogenic shock 132.92 10.43 763 753840 41151 78948634
Haematuria 131.58 10.43 1107 753496 67729 78922056
Atrial flutter 131.37 10.43 477 754126 21148 78968637
Grip strength decreased 131.26 10.43 24 754579 21845 78967940
Cardiac arrest 130.59 10.43 2322 752281 169774 78820011
Haematemesis 129.35 10.43 893 753710 51371 78938414
Accidental exposure to product 128.32 10.43 68 754535 31254 78958531
Cardiomyopathy 127.92 10.43 576 754027 28198 78961587
Lower respiratory tract infection 126.44 10.43 711 753892 128509 78861276
Oliguria 125.92 10.43 390 754213 15919 78973866
Psychotic disorder 124.03 10.43 125 754478 41277 78948508
Pemphigoid 123.64 10.43 372 754231 14943 78974842
Arrhythmia 123.36 10.43 997 753606 60275 78929510
Migraine 122.32 10.43 421 754182 87072 78902713
Pseudo-Bartter syndrome 121.68 10.43 42 754561 50 78989735
Rheumatoid nodule 121.57 10.43 12 754591 17426 78972359
Adverse drug reaction 121.24 10.43 281 754322 66111 78923674
Nephrocalcinosis 121.20 10.43 106 754497 1396 78988389
Cerebrovascular accident 119.86 10.43 2101 752502 153191 78836594
Pericardial effusion 117.39 10.43 795 753808 45442 78944343
Gravitational oedema 115.81 10.43 113 754490 1726 78988059
Left ventricular failure 115.33 10.43 270 754333 9311 78980474
Hyperuricaemia 115.20 10.43 307 754296 11492 78978293
Sedation complication 114.83 10.43 368 754235 15301 78974484
Drug resistance 114.83 10.43 138 754465 42075 78947710
Blood calcium decreased 113.48 10.43 598 754005 31221 78958564
Azotaemia 112.76 10.43 245 754358 8031 78981754
Inflammation 112.44 10.43 480 754123 93273 78896512
Insomnia 111.09 10.43 1641 752962 243529 78746256
Anaphylactic reaction 111.05 10.43 412 754191 83331 78906454
Arthritis 109.75 10.43 637 753966 114243 78875542
Pruritus 109.58 10.43 2869 751734 391779 78598006
Musculoskeletal pain 108 10.43 549 754054 101805 78887980
Myocardial ischaemia 105.43 10.43 500 754103 25019 78964766
Tenosynovitis 105.12 10.43 12 754591 15542 78974243
Haemodialysis 104.71 10.43 394 754209 17774 78972011
Blood loss anaemia 104.64 10.43 354 754249 15144 78974641
Therapeutic response decreased 103.72 10.43 307 754296 66546 78923239
Atrioventricular block complete 102.27 10.43 368 754235 16242 78973543
Haemoptysis 102.00 10.43 891 753712 55108 78934677
Product dose omission issue 101.31 10.43 1689 752914 245848 78743937
Aortic stenosis 101.12 10.43 221 754382 7274 78982511
Bradyarrhythmia 99.96 10.43 157 754446 3989 78985796
Coronary artery bypass 98.54 10.43 193 754410 5869 78983916
Blister 98.51 10.43 693 753910 118783 78871002
Psoriasis 98.27 10.43 474 754129 89113 78900672
Respiratory distress 97.96 10.43 912 753691 57427 78932358
Dialysis 97.13 10.43 389 754214 18073 78971712
Intentional self-injury 96.97 10.43 98 754505 32321 78957464
Bone erosion 96.14 10.43 25 754578 17822 78971963
Mucosal inflammation 95.60 10.43 379 754224 75201 78914584
Immune reconstitution inflammatory syndrome 95.26 10.43 10 754593 13831 78975954
Cellulitis 94.22 10.43 1503 753100 107557 78882228
Fear 93.93 10.43 435 754168 21551 78968234
Concomitant disease aggravated 93.56 10.43 306 754297 12861 78976924
Osteoarthritis 93.42 10.43 466 754137 86843 78902942
Foot deformity 93.25 10.43 56 754547 24018 78965767
Hypochloraemia 93.13 10.43 117 754486 2398 78987387
Upper gastrointestinal haemorrhage 92.53 10.43 690 753913 40690 78949095
Iron deficiency anaemia 91.91 10.43 483 754120 25189 78964596
Uveitis 91.77 10.43 23 754580 16807 78972978
Joint stiffness 91.67 10.43 153 754450 40677 78949108
Liver injury 91.48 10.43 255 754348 56359 78933426
Lip dry 90.24 10.43 18 754585 15400 78974385
Venous pressure jugular increased 89.41 10.43 85 754518 1255 78988530
Myelosuppression 88.63 10.43 153 754450 40143 78949642
Unevaluable event 87.90 10.43 858 753745 54727 78935058
Eosinophilia 87.59 10.43 731 753872 44614 78945171
Left ventricular dysfunction 87.14 10.43 389 754214 18972 78970813
Aortic valve incompetence 87.08 10.43 242 754361 9288 78980497
Bundle branch block left 86.75 10.43 273 754330 11240 78978545
Ischaemic stroke 86.71 10.43 574 754029 32557 78957228
Infective pulmonary exacerbation of cystic fibrosis 86.63 10.43 10 754593 12841 78976944
Metabolic acidosis 86.46 10.43 1176 753427 81353 78908432
Prerenal failure 86.35 10.43 138 754465 3560 78986225
Toxic skin eruption 85.79 10.43 428 754175 21865 78967920
Cardiac output decreased 85.39 10.43 96 754507 1742 78988043
Blood sodium decreased 84.54 10.43 572 754031 32683 78957102
Joint range of motion decreased 84.11 10.43 115 754488 33167 78956618
Depressed level of consciousness 83.86 10.43 1333 753270 95319 78894466
Facet joint syndrome 83.67 10.43 6 754597 11296 78978489
Cerebral haemorrhage 83.41 10.43 874 753729 56799 78932986
Prothrombin time prolonged 83.31 10.43 349 754254 16550 78973235
Colitis ulcerative 81.95 10.43 126 754477 34616 78955169
Blood bilirubin increased 81.80 10.43 973 753630 65259 78924526
Haematotoxicity 81.22 10.43 23 754580 15496 78974289
International normalised ratio decreased 79.82 10.43 211 754392 7859 78981926
Anxiety 79.23 10.43 1769 752834 246743 78743042
Device issue 78.76 10.43 84 754519 27024 78962761
Hypoglycaemic coma 77.92 10.43 152 754451 4608 78985177
Drug reaction with eosinophilia and systemic symptoms 77.68 10.43 940 753663 63304 78926481
Exercise tolerance decreased 77.67 10.43 225 754378 8846 78980939
Jugular vein distension 77.39 10.43 82 754521 1388 78988397
Polyuria 77.11 10.43 314 754289 14700 78975085
Therapeutic response shortened 76.80 10.43 27 754576 15836 78973949
Confusional state 76.47 10.43 3711 750892 314286 78675499
Pulmonary arterial pressure increased 76.46 10.43 147 754456 4408 78985377
Pulmonary congestion 76.13 10.43 478 754125 26622 78963163
Blood pressure fluctuation 74.95 10.43 353 754250 66792 78922993
Lower gastrointestinal haemorrhage 74.86 10.43 327 754276 15798 78973987
Asthma 74.83 10.43 867 753736 134228 78855557
Drug tolerance decreased 74.21 10.43 16 754587 12962 78976823
Throat irritation 74.20 10.43 174 754429 40772 78949013
Concomitant disease progression 73.53 10.43 124 754479 3349 78986436
Ventricular extrasystoles 73.51 10.43 375 754228 19329 78970456
Live birth 73.45 10.43 43 754560 18701 78971084
Congestive hepatopathy 72.98 10.43 144 754459 4403 78985382
Anhedonia 72.92 10.43 307 754296 14591 78975194
Gastrointestinal tract mucosal pigmentation 72.73 10.43 68 754535 982 78988803
Poisoning 72.66 10.43 79 754524 25193 78964592
Therapy partial responder 72.40 10.43 37 754566 17360 78972425
Blood creatine increased 71.98 10.43 225 754378 9230 78980555
Progressive multifocal leukoencephalopathy 70.35 10.43 55 754548 20545 78969240
Vitamin B1 deficiency 70.31 10.43 56 754547 642 78989143
Dry eye 70.12 10.43 153 754450 36778 78953007
Oropharyngeal pain 69.79 10.43 679 753924 108674 78881111
Device difficult to use 69.75 10.43 20 754583 13365 78976420
Neuropathy peripheral 69.56 10.43 930 753673 140375 78849410
Oral herpes 69.24 10.43 95 754508 27359 78962426
Type 2 diabetes mellitus 68.76 10.43 292 754311 56830 78932955
Dilatation ventricular 68.66 10.43 133 754470 4011 78985774
Oesophageal varices haemorrhage 67.81 10.43 134 754469 4102 78985683
Bursitis 67.64 10.43 149 754454 35695 78954090
Adverse event 67.54 10.43 316 754287 59898 78929887
Seizure 67.28 10.43 1320 753283 187514 78802271
Head injury 67.23 10.43 593 754010 36776 78953009
Schizophrenia 67.05 10.43 31 754572 15409 78974376
Neoplasm progression 66.74 10.43 257 754346 51425 78938360
Blood parathyroid hormone decreased 66.71 10.43 10 754593 10526 78979259
Dilatation atrial 66.47 10.43 123 754480 3581 78986204
Sudden death 66.34 10.43 402 754201 22109 78967676
Dyspnoea paroxysmal nocturnal 66.11 10.43 93 754510 2135 78987650
Cardiac murmur 66.07 10.43 311 754292 15513 78974272
Troponin increased 66.02 10.43 358 754245 18897 78970888
Sepsis 65.76 10.43 3149 751454 266279 78723506
Dry mouth 65.67 10.43 525 754078 87494 78902291
Injection site warmth 65.44 10.43 29 754574 14778 78975007
Diastolic dysfunction 65.27 10.43 238 754365 10573 78979212
Injection site rash 65.12 10.43 45 754558 17909 78971876
Vascular purpura 64.78 10.43 110 754493 2988 78986797
Appendicitis 64.34 10.43 61 754542 20733 78969052
Muscle spasticity 64.13 10.43 65 754538 21410 78968375
Ankylosing spondylitis 64.04 10.43 18 754585 12187 78977598
Adjustment disorder with depressed mood 64.01 10.43 6 754597 9080 78980705
Hepatic cirrhosis 63.88 10.43 556 754047 34350 78955435
Nephrotic syndrome 63.30 10.43 241 754362 10933 78978852
Loss of consciousness 63.09 10.43 2057 752546 165886 78823899
Depression 63.02 10.43 1565 753038 215225 78774560
Hyponatraemic syndrome 62.85 10.43 55 754548 725 78989060
Incorrect route of product administration 62.83 10.43 149 754454 34780 78955005
Hepatotoxicity 62.74 10.43 261 754342 51091 78938694
Hypovolaemic shock 62.46 10.43 256 754347 12020 78977765
Cor pulmonale 61.92 10.43 91 754512 2177 78987608
Visual impairment 61.81 10.43 565 754038 91566 78898219
Blood alkaline phosphatase increased 61.77 10.43 895 753708 62769 78927016
Hepatocellular carcinoma 61.73 10.43 207 754396 8814 78980971
Microcytic anaemia 61.71 10.43 147 754456 5127 78984658
Tendonitis 61.58 10.43 81 754522 23749 78966036
Prostate cancer 61.38 10.43 140 754463 33128 78956657
Angina pectoris 60.83 10.43 753 753850 50979 78938806
Faeces discoloured 60.28 10.43 477 754126 28650 78961135
Injection site urticaria 60.12 10.43 23 754580 12803 78976982
Low cardiac output syndrome 59.88 10.43 61 754542 984 78988801
Activated partial thromboplastin time prolonged 59.67 10.43 280 754323 13948 78975837
Impaired work ability 59.43 10.43 59 754544 19622 78970163
Serotonin syndrome 59.38 10.43 222 754381 44805 78944980
Abdominal pain upper 58.67 10.43 1640 752963 222179 78767606
Electrolyte imbalance 58.67 10.43 496 754107 30385 78959400
Disability 58.10 10.43 46 754557 17074 78972711
Sciatica 57.96 10.43 144 754459 33078 78956707
Angina unstable 57.83 10.43 309 754294 16218 78973567
Bone density decreased 57.65 10.43 27 754576 13320 78976465
Poor venous access 57.62 10.43 52 754551 18097 78971688
Jaundice 57.44 10.43 764 753839 52585 78937200
Unintentional medical device removal 57.37 10.43 4 754599 7708 78982077
Acne 57.31 10.43 106 754497 27084 78962701
Ear infection 57.19 10.43 153 754450 34279 78955506
Hepatorenal syndrome 57.00 10.43 125 754478 4124 78985661
Basal cell carcinoma 56.27 10.43 174 754429 37201 78952584
International normalised ratio abnormal 56.23 10.43 150 754453 5618 78984167
Ventricular dysfunction 56.08 10.43 154 754449 5869 78983916
Breast cancer stage II 55.54 10.43 6 754597 8114 78981671
Ventricular fibrillation 55.06 10.43 502 754101 31424 78958361
Encephalopathy 54.91 10.43 920 753683 66477 78923308
Irritability 54.81 10.43 202 754401 40942 78948843
Sinus node dysfunction 54.74 10.43 179 754424 7522 78982263
Muscle haemorrhage 54.65 10.43 157 754446 6143 78983642
C-reactive protein increased 54.52 10.43 875 753728 128152 78861633
Muscle twitching 54.48 10.43 94 754509 24670 78965115
Memory impairment 54.40 10.43 737 753866 110997 78878788
Dystonia 54.01 10.43 74 754529 21325 78968460
Balance disorder 53.51 10.43 1269 753334 97588 78892197
Urinary tract discomfort 53.28 10.43 49 754554 692 78989093
Atrioventricular block first degree 53.25 10.43 247 754356 12244 78977541
Amnesia 52.82 10.43 364 754239 62693 78927092
Substance abuse 52.55 10.43 17 754586 10509 78979276
Ovarian cyst 52.54 10.43 27 754576 12628 78977157
Fear of injection 52.48 10.43 5 754598 7469 78982316
Autoimmune disorder 52.26 10.43 48 754555 16564 78973221
Feeling hot 51.95 10.43 341 754262 59393 78930392
Coronary arterial stent insertion 51.83 10.43 150 754453 5894 78983891
Malignant neoplasm progression 51.39 10.43 941 753662 135049 78854736
Myopathy 51.26 10.43 352 754251 20211 78969574
Back pain 51.15 10.43 2354 752249 301826 78687959
Exposure to toxic agent 50.94 10.43 12 754591 9146 78980639
Neutrophil count decreased 50.48 10.43 607 753996 93352 78896433
Disease recurrence 50.35 10.43 230 754373 43879 78945906
Abdominal pain 50.08 10.43 3097 751506 386472 78603313
Multiple-drug resistance 50.08 10.43 11 754592 8797 78980988
Paradoxical drug reaction 49.94 10.43 5 754598 7180 78982605
Colitis 49.85 10.43 448 754155 72859 78916926
Agranulocytosis 49.78 10.43 648 753955 44382 78945403
Cardiac valve disease 49.73 10.43 143 754460 5598 78984187
Sinus bradycardia 49.29 10.43 408 754195 24839 78964946
Drug withdrawal syndrome 49.23 10.43 166 754437 34552 78955233
Neck pain 49.08 10.43 466 754137 74951 78914834
Eye pain 49.08 10.43 186 754417 37392 78952393
Osteoporosis 49.06 10.43 305 754298 53807 78935978
Nodule 49.04 10.43 89 754514 22905 78966880
Circulatory collapse 48.56 10.43 558 754045 37110 78952675
Cataract 48.45 10.43 366 754237 61754 78928031
Hepatic function abnormal 48.37 10.43 966 753637 72141 78917644
Breast cancer stage I 48.35 10.43 4 754599 6696 78983089
Subcutaneous haematoma 48.31 10.43 91 754512 2686 78987099
Ischaemic hepatitis 48.25 10.43 107 754496 3557 78986228
Mood swings 47.95 10.43 71 754532 19809 78969976
Abdominal wall haematoma 47.78 10.43 127 754476 4746 78985039
Dyspepsia 47.62 10.43 732 753871 107955 78881830
Dermatitis exfoliative 47.55 10.43 216 754387 10613 78979172
No adverse event 47.34 10.43 186 754417 37006 78952779
Occult blood positive 47.15 10.43 158 754445 6725 78983060
Ecchymosis 47.02 10.43 275 754328 14931 78974854
Injection site haemorrhage 46.93 10.43 123 754480 27747 78962038
Pathogen resistance 46.85 10.43 40 754563 14302 78975483
Chest pain 46.84 10.43 3186 751417 279118 78710667
Cholestasis 46.45 10.43 722 753881 51387 78938398
Aggression 46.31 10.43 287 754316 50671 78939114
Myoclonus 46.22 10.43 432 754171 27228 78962557
Panniculitis 46.22 10.43 30 754573 12341 78977444
Tachyarrhythmia 46.10 10.43 158 754445 6804 78982981
Pericardial haemorrhage 45.97 10.43 119 754484 4376 78985409
Multiple sclerosis 45.96 10.43 88 754515 22194 78967591
Blood pressure increased 45.82 10.43 1588 753015 209772 78780013
Wrong technique in product usage process 45.75 10.43 462 754141 73413 78916372
Road traffic accident 45.59 10.43 235 754368 43429 78946356
Post transplant lymphoproliferative disorder 45.35 10.43 26 754577 11438 78978347
Renal disorder 45.33 10.43 603 754000 41502 78948283
Breast cancer female 45.32 10.43 26 754577 11435 78978350
Laryngitis 45.16 10.43 51 754552 15988 78973797
Depressed mood 45.13 10.43 271 754332 48209 78941576
Photophobia 45.09 10.43 78 754525 20450 78969335
Uterine perforation 44.84 10.43 4 754599 6299 78983486
Gestational diabetes 44.75 10.43 4 754599 6289 78983496
Erythema 44.48 10.43 1695 752908 221595 78768190
Troponin T increased 44.31 10.43 101 754502 3421 78986364
Dyspnoea at rest 44.29 10.43 161 754442 7141 78982644
Oxygen saturation decreased 44.25 10.43 1564 753039 127483 78862302
Herpes zoster 44.23 10.43 617 753986 92466 78897319
Shock 44.16 10.43 617 753986 42931 78946854
Frequent bowel movements 44.13 10.43 138 754465 29401 78960384
Oxygen consumption increased 44.08 10.43 125 754478 4854 78984931
Illness 43.82 10.43 259 754344 46252 78943533
Generalised tonic-clonic seizure 43.80 10.43 240 754363 43670 78946115
Cardiac amyloidosis 43.43 10.43 69 754534 1771 78988014
Acute graft versus host disease 43.25 10.43 21 754582 10146 78979639
Plasma cell myeloma 43.01 10.43 726 753877 52533 78937252
Blood creatinine abnormal 42.72 10.43 121 754482 4696 78985089
Prescribed overdose 42.37 10.43 199 754404 37684 78952101
Ventricular arrhythmia 42.36 10.43 181 754422 8659 78981126
Vascular graft 42.32 10.43 72 754531 1959 78987826
Musculoskeletal disorder 42.27 10.43 87 754516 21361 78968424
Neutropenic sepsis 42.18 10.43 124 754479 26940 78962845
Device use error 42.17 10.43 8 754595 7093 78982692
Peritonitis bacterial 42.14 10.43 191 754412 9376 78980409
Hypercapnia 42.09 10.43 182 754421 8753 78981032
Product storage error 42.08 10.43 55 754548 16171 78973614
Device dislocation 41.93 10.43 117 754486 25853 78963932
Lymphadenopathy 41.87 10.43 313 754290 52934 78936851
Renal artery stenosis 41.77 10.43 98 754505 3384 78986401
Retinitis 41.76 10.43 3 754600 5640 78984145
Catheter management 41.68 10.43 101 754502 3562 78986223
Heparin-induced thrombocytopenia 41.68 10.43 192 754411 9490 78980295
Hypocoagulable state 41.67 10.43 74 754529 2085 78987700
Paranoia 41.63 10.43 75 754528 19357 78970428
Device interaction 41.56 10.43 43 754560 707 78989078
Septic shock 41.53 10.43 1486 753117 121315 78868470
Cytomegalovirus infection 41.49 10.43 235 754368 42409 78947376
Hypoalbuminaemia 41.48 10.43 344 754259 20953 78968832
White blood cell count decreased 41.42 10.43 1412 753191 186876 78802909
Influenza like illness 41.34 10.43 456 754147 71251 78918534
Blood pressure diastolic abnormal 41.24 10.43 74 754529 19128 78970657
Drug dependence 41.13 10.43 222 754381 40547 78949238
Arteriospasm coronary 41.11 10.43 7 754596 6709 78983076
Disorientation 41.03 10.43 828 753775 61948 78927837
Tooth infection 40.96 10.43 72 754531 18760 78971025
Cardiorenal syndrome 40.87 10.43 62 754541 1527 78988258
Blepharospasm 40.86 10.43 4 754599 5847 78983938
Blood iron decreased 40.75 10.43 268 754335 15166 78974619
Acute graft versus host disease in skin 40.73 10.43 11 754592 7647 78982138
Cardio-respiratory arrest 40.71 10.43 1329 753274 107181 78882604
Nodal rhythm 40.67 10.43 91 754512 3044 78986741
Breast cancer 40.46 10.43 173 754430 33608 78956177
Maternal exposure timing unspecified 40.34 10.43 4 754599 5788 78983997
Anticoagulation drug level above therapeutic 40.33 10.43 99 754504 3521 78986264
Cardiac pacemaker insertion 40.20 10.43 134 754469 5688 78984097
Lupus-like syndrome 40.19 10.43 43 754560 13814 78975971
Coagulopathy 40.16 10.43 519 754084 35487 78954298
Intra-abdominal haematoma 39.86 10.43 86 754517 2805 78986980
Peripartum cardiomyopathy 39.86 10.43 22 754581 127 78989658
Feeling abnormal 39.80 10.43 1174 753429 158025 78831760
Disturbance in attention 39.76 10.43 299 754304 50502 78939283
Drug use disorder 39.75 10.43 16 754587 8635 78981150
Blood albumin decreased 39.70 10.43 377 754226 23866 78965919
Arteriosclerosis 39.66 10.43 302 754301 17925 78971860
Anosmia 39.60 10.43 17 754586 8827 78980958
Hypersensitivity vasculitis 39.54 10.43 150 754453 6793 78982992
Superinfection 39.50 10.43 119 754484 4783 78985002
Gastritis erosive 39.46 10.43 205 754398 10642 78979143
Haemophagocytic lymphohistiocytosis 39.40 10.43 93 754510 21744 78968041
Hypercalciuria 39.40 10.43 36 754567 504 78989281
Dermatitis bullous 39.23 10.43 250 754353 13995 78975790
Diabetes mellitus inadequate control 39.07 10.43 376 754227 23888 78965897
Alveolar osteitis 39.03 10.43 44 754559 801 78988984
Hypercreatininaemia 39.01 10.43 49 754554 1004 78988781
Left ventricular dilatation 38.84 10.43 50 754553 1051 78988734
Systemic infection 38.74 10.43 22 754581 9730 78980055
Paraesthesia oral 38.70 10.43 85 754518 20386 78969399
Pain in extremity 38.69 10.43 2947 751656 361591 78628194
Tachypnoea 38.69 10.43 469 754134 31594 78958191
Bundle branch block right 38.45 10.43 209 754394 11042 78978743
Cerebral haematoma 38.36 10.43 163 754440 7779 78982006
Neuroleptic malignant syndrome 38.24 10.43 133 754470 27426 78962359
Gastric disorder 38.22 10.43 203 754400 37230 78952555
Right ventricular dysfunction 38.20 10.43 80 754523 2555 78987230
Joint dislocation 37.54 10.43 64 754539 16875 78972910
Immunodeficiency 37.47 10.43 95 754508 21673 78968112
Injection site mass 37.19 10.43 85 754518 20099 78969686
Normochromic normocytic anaemia 36.86 10.43 158 754445 7569 78982216
Alanine aminotransferase abnormal 36.69 10.43 19 754584 8848 78980937
Muscle spasms 36.67 10.43 1318 753285 173412 78816373
Pseudoporphyria 36.61 10.43 37 754566 591 78989194
Wheezing 36.42 10.43 833 753770 115831 78873954
Atrial enlargement 36.22 10.43 47 754556 996 78988789
Pelvic pain 36.12 10.43 44 754559 13337 78976448
Vomiting 36.09 10.43 5641 748962 660187 78329598
Central nervous system lesion 36.04 10.43 44 754559 13324 78976461
Spontaneous haematoma 35.89 10.43 55 754548 1367 78988418
Eye irritation 35.80 10.43 90 754513 20591 78969194
Left ventricular hypertrophy 35.66 10.43 204 754399 10987 78978798
Alkalosis 35.64 10.43 35 754568 539 78989246
Crying 35.60 10.43 106 754497 22937 78966848
Right ventricular hypertrophy 35.39 10.43 59 754544 1578 78988207
Ocular hyperaemia 35.31 10.43 142 754461 28064 78961721
Pharyngitis 35.24 10.43 102 754501 22273 78967512
Drug dose omission by device 35.14 10.43 8 754595 6242 78983543
Impaired quality of life 35.07 10.43 51 754552 14335 78975450
Hypophagia 35.04 10.43 614 753989 44753 78945032
Ear pain 34.83 10.43 176 754427 32693 78957092
Gouty arthritis 34.77 10.43 55 754548 1406 78988379
Upper respiratory tract infection 34.70 10.43 630 753973 90538 78899247
Sexual dysfunction 34.63 10.43 15 754588 7748 78982037
Tongue disorder 34.60 10.43 49 754554 13926 78975859
Nephrogenic anaemia 34.59 10.43 98 754505 3804 78985981
Sputum culture positive 34.53 10.43 96 754507 3685 78986100
Purpura 34.16 10.43 308 754295 19219 78970566
Polyomavirus-associated nephropathy 34.15 10.43 6 754597 5621 78984164
Renal tubular necrosis 34.12 10.43 375 754228 24664 78965121
Emotional disorder 34.10 10.43 52 754551 14335 78975450
Juvenile idiopathic arthritis 33.94 10.43 3 754600 4760 78985025
Suspected suicide 33.94 10.43 30 754573 10546 78979239
Condition aggravated 33.91 10.43 4188 750415 496936 78492849
Left atrial enlargement 33.91 10.43 49 754554 1154 78988631
Gouty tophus 33.82 10.43 30 754573 403 78989382
Right-to-left cardiac shunt 33.80 10.43 24 754579 228 78989557
Mucormycosis 33.80 10.43 19 754584 8450 78981335
Haematocrit decreased 33.77 10.43 789 753814 60523 78929262
Diabetic ketoacidosis 33.76 10.43 187 754416 33935 78955850
Syringe issue 33.59 10.43 9 754594 6289 78983496
Mania 33.56 10.43 77 754526 18183 78971602
Rhinorrhoea 33.44 10.43 512 754091 75562 78914223
Poisoning deliberate 33.32 10.43 81 754522 18747 78971038
Epstein-Barr virus infection 33.31 10.43 53 754550 14363 78975422
Ammonia increased 33.31 10.43 152 754451 7483 78982302
Acute coronary syndrome 33.30 10.43 326 754277 20807 78968978
Ulcer 33.19 10.43 158 754445 29814 78959971
Disturbance in social behaviour 33.17 10.43 4 754599 4966 78984819
Nephrosclerosis 33.13 10.43 61 754542 1769 78988016
Joint effusion 33.08 10.43 76 754527 17938 78971847
Acrodermatitis enteropathica 33.03 10.43 9 754594 0 78989785
Acute generalised exanthematous pustulosis 32.70 10.43 277 754326 16977 78972808
Haemorrhage 32.65 10.43 1110 753493 90008 78899777
Long QT syndrome 32.55 10.43 127 754476 5828 78983957
Paracentesis 32.52 10.43 51 754552 1294 78988491
Joint destruction 32.49 10.43 8 754595 5917 78983868
Asterixis 32.27 10.43 76 754527 2631 78987154
Arteriosclerosis coronary artery 32.19 10.43 283 754320 17533 78972252
Varices oesophageal 32.13 10.43 127 754476 5864 78983921
Aspiration pleural cavity 31.96 10.43 56 754547 1561 78988224
Extrapyramidal disorder 31.77 10.43 109 754494 22570 78967215
Haemorrhage subcutaneous 31.72 10.43 109 754494 4700 78985085
Hyperhidrosis 31.72 10.43 1143 753460 150349 78839436
Ventricular hypertrophy 31.67 10.43 140 754463 6798 78982987
Sudden cardiac death 31.52 10.43 115 754488 5110 78984675
Nephrolithiasis 31.47 10.43 337 754266 52954 78936831
Hypomania 31.46 10.43 16 754587 7528 78982257
Left ventricular enlargement 31.35 10.43 37 754566 709 78989076
Abdominal cavity drainage 31.35 10.43 39 754564 791 78988994
Mental disorder 31.27 10.43 171 754432 31131 78958654
Nightmare 31.24 10.43 132 754471 25729 78964056
Amenorrhoea 31.07 10.43 17 754586 7675 78982110
Drug specific antibody present 31.06 10.43 12 754591 6640 78983145
Left ventricle outflow tract obstruction 31.05 10.43 28 754575 385 78989400
Heavy menstrual bleeding 30.99 10.43 53 754550 13958 78975827
Vital capacity decreased 30.96 10.43 59 754544 1757 78988028
Chronic sinusitis 30.95 10.43 47 754556 12979 78976806
Hypercreatinaemia 30.94 10.43 25 754578 293 78989492
Chills 30.88 10.43 1221 753382 159013 78830772
Neuromyopathy 30.85 10.43 54 754549 1504 78988281
Hot flush 30.83 10.43 351 754252 54526 78935259
Bone pain 30.74 10.43 358 754245 55384 78934401
Liver function test increased 30.70 10.43 235 754368 39538 78950247
Rash maculo-papular 30.69 10.43 721 753882 55357 78934428
Anal abscess 30.67 10.43 26 754577 9329 78980456
Atrial thrombosis 30.65 10.43 90 754513 3566 78986219
Tardive dyskinesia 30.44 10.43 33 754570 10538 78979247
Complication of device insertion 30.41 10.43 11 754592 6339 78983446
Haemorrhage intracranial 30.25 10.43 380 754223 25813 78963972
General physical health deterioration 30.15 10.43 2219 752384 273019 78716766
Hypocalvaria 30.15 10.43 12 754591 27 78989758
Multimorbidity 29.96 10.43 51 754552 1388 78988397
Antibiotic level above therapeutic 29.94 10.43 36 754567 704 78989081
Alkalosis hypochloraemic 29.94 10.43 30 754573 474 78989311
Hyperparathyroidism secondary 29.90 10.43 73 754530 2587 78987198
Mood altered 29.87 10.43 79 754524 17768 78972017
Throat tightness 29.81 10.43 149 754454 27758 78962027
Cyanosis 29.80 10.43 367 754236 24815 78964970
Bronchial secretion retention 29.72 10.43 96 754507 4008 78985777
Ventricular dyssynchrony 29.69 10.43 15 754588 70 78989715
Coagulation time prolonged 29.69 10.43 70 754533 2425 78987360
Diplopia 29.63 10.43 190 754413 33276 78956509
BRASH syndrome 29.51 10.43 42 754561 975 78988810
Ventricular internal diameter abnormal 29.27 10.43 22 754581 230 78989555
Metastases to liver 29.21 10.43 153 754450 28161 78961624
Tunnel vision 29.07 10.43 53 754550 1525 78988260
Animal scratch 29.07 10.43 51 754552 1423 78988362
Mitral valve disease 29.03 10.43 81 754522 3116 78986669
Retroperitoneal haematoma 28.98 10.43 113 754490 5184 78984601
Scrotal oedema 28.90 10.43 53 754550 1532 78988253
Product quality issue 28.88 10.43 195 754408 33745 78956040
Chronic respiratory failure 28.87 10.43 78 754525 2944 78986841
Chronic graft versus host disease 28.86 10.43 14 754589 6767 78983018
Mental status changes 28.82 10.43 834 753769 66125 78923660
Gastric ulcer 28.79 10.43 466 754137 33439 78956346
Catheter site infection 28.70 10.43 134 754469 6661 78983124
Haematoma muscle 28.58 10.43 71 754532 2544 78987241
Prothrombin time shortened 28.54 10.43 81 754522 3147 78986638
Angiotensin converting enzyme inhibitor foetopathy 28.49 10.43 12 754591 33 78989752
Blood lactic acid 28.32 10.43 28 754575 435 78989350
Tachycardia 28.20 10.43 1384 753219 176384 78813401
Medication error 28.19 10.43 850 753753 67792 78921993
Pharyngitis streptococcal 28.11 10.43 36 754567 10678 78979107
Mydriasis 28.10 10.43 80 754523 17563 78972222
Interstitial lung disease 28.05 10.43 1319 753284 111281 78878504
Malignant melanoma 28.04 10.43 61 754542 14680 78975105
Gastrointestinal vascular malformation haemorrhagic 27.99 10.43 36 754567 756 78989029
Altered state of consciousness 27.97 10.43 576 754027 43246 78946539
Duodenal ulcer haemorrhage 27.90 10.43 138 754465 7025 78982760
Dermatitis exfoliative generalised 27.85 10.43 139 754464 7102 78982683
Brain natriuretic peptide abnormal 27.81 10.43 36 754567 761 78989024
Myoglobin blood increased 27.79 10.43 79 754524 3072 78986713
Thrombocytopenia 27.78 10.43 2892 751711 262367 78727418
Mouth ulceration 27.72 10.43 231 754372 38163 78951622
Cytomegalovirus infection reactivation 27.64 10.43 25 754578 8691 78981094
Blood sodium increased 27.60 10.43 104 754499 4694 78985091
Eye pruritus 27.39 10.43 101 754502 20469 78969316
Electrocardiogram ST segment abnormal 27.34 10.43 51 754552 1494 78988291
Synovial cyst 27.27 10.43 33 754570 10032 78979753
Anger 27.20 10.43 78 754525 17084 78972701
Graft versus host disease 27.10 10.43 64 754539 14962 78974823
Influenza 27.10 10.43 978 753625 128628 78861157
Hepatitis B reactivation 26.94 10.43 12 754591 6096 78983689
Second primary malignancy 26.79 10.43 60 754543 14290 78975495
Endocarditis 26.77 10.43 182 754421 10415 78979370
Inflammatory bowel disease 26.71 10.43 10 754593 5641 78984144
Hepatic cancer 26.70 10.43 181 754422 10348 78979437
Mitral valve stenosis 26.68 10.43 44 754559 1166 78988619
Mobility decreased 26.67 10.43 917 753686 121258 78868527
Staphylococcal sepsis 26.65 10.43 234 754369 14492 78975293
Diffuse large B-cell lymphoma recurrent 26.62 10.43 4 754599 4203 78985582
Therapy non-responder 26.62 10.43 667 753936 91638 78898147
Intestinal haemorrhage 26.61 10.43 126 754477 6300 78983485
Abdominal distension 26.57 10.43 1386 753217 118264 78871521
Protein total decreased 26.56 10.43 162 754441 8930 78980855
Chronic hepatic failure 26.55 10.43 40 754563 979 78988806
Sleep terror 26.52 10.43 5 754598 4453 78985332
Right atrial dilatation 26.47 10.43 35 754568 756 78989029
Gastric ulcer haemorrhage 26.47 10.43 161 754442 8866 78980919
Mitral valve thickening 26.45 10.43 26 754577 401 78989384
Pre-eclampsia 26.41 10.43 17 754586 7024 78982761
Seronegative arthritis 26.39 10.43 6 754597 4686 78985099
Subdural haemorrhage 26.38 10.43 119 754484 5829 78983956
Right atrial enlargement 26.25 10.43 25 754578 370 78989415
Extrasystoles 26.15 10.43 139 754464 7280 78982505
Drug effective for unapproved indication 26.14 10.43 12 754591 5989 78983796
Diabetic nephropathy 26.11 10.43 74 754529 2873 78986912
Metabolic encephalopathy 26.10 10.43 162 754441 8985 78980800
Alcohol interaction 25.93 10.43 7 754596 4867 78984918
Neuralgia 25.88 10.43 197 754406 33187 78956598
Aortic valve stenosis 25.84 10.43 109 754494 5185 78984600
Anal fistula 25.73 10.43 17 754586 6927 78982858
Decreased appetite 25.72 10.43 3656 750947 338762 78651023
Scleritis 25.67 10.43 5 754598 4351 78985434
Anticoagulation drug level increased 25.62 10.43 34 754569 737 78989048
Withdrawal syndrome 25.58 10.43 149 754454 26705 78963080
Platelet count decreased 25.57 10.43 2157 752446 192507 78797278
Lung transplant 25.53 10.43 98 754505 4463 78985322
Demyelination 25.46 10.43 23 754580 8000 78981785
Erysipelas 25.44 10.43 183 754420 10667 78979118
Menstruation irregular 25.38 10.43 8 754595 5028 78984757
Cerebral infarction 25.22 10.43 588 754015 45088 78944697
Anosognosia 25.20 10.43 3 754600 3761 78986024
Aphthous ulcer 25.16 10.43 79 754524 16810 78972975
Accidental death 25.13 10.43 5 754598 4286 78985499
Lymphoedema 24.98 10.43 202 754401 12211 78977574
Blood pressure systolic decreased 24.93 10.43 185 754418 10891 78978894
Granuloma 24.91 10.43 25 754578 8272 78981513
BK virus infection 24.78 10.43 28 754575 8776 78981009
Injection site induration 24.74 10.43 34 754569 9785 78980000
Catheter placement 24.73 10.43 73 754530 2901 78986884
Respiratory arrest 24.72 10.43 389 754214 57161 78932624
Wound secretion 24.66 10.43 120 754483 6068 78983717
Hepatic steatosis 24.63 10.43 233 754370 37505 78952280
Hyperglycaemia 24.49 10.43 854 753749 69481 78920304
Mycobacterial infection 24.37 10.43 3 754600 3665 78986120
Akathisia 24.30 10.43 56 754547 13203 78976582
Faecal calprotectin increased 24.26 10.43 11 754592 5530 78984255
Fungal infection 24.25 10.43 265 754338 41483 78948302
Pregnancy with contraceptive device 24.24 10.43 3 754600 3651 78986134
Hypothermia 24.17 10.43 325 754278 22421 78967364
Tuberculosis 24.14 10.43 69 754534 15129 78974656
Cushingoid 24.14 10.43 33 754570 9519 78980266
Abnormal behaviour 24.14 10.43 224 754379 36197 78953588
Blood chloride decreased 24.08 10.43 146 754457 8031 78981754
Peripheral arterial occlusive disease 24.03 10.43 147 754456 8111 78981674
Ventricular hyperkinesia 23.92 10.43 21 754582 278 78989507
Rash pruritic 23.91 10.43 506 754097 71123 78918662
Ventricular hypokinesia 23.82 10.43 160 754443 9119 78980666
Acidosis 23.81 10.43 289 754314 19473 78970312
Neurotoxicity 23.77 10.43 195 754408 32323 78957462
Walking distance test abnormal 23.69 10.43 32 754571 706 78989079
Hypochromasia 23.61 10.43 31 754572 665 78989120
Gastric varices 23.59 10.43 32 754571 709 78989076
Delayed graft function 23.58 10.43 80 754523 3427 78986358
Chronic left ventricular failure 23.56 10.43 38 754565 988 78988797
Ovarian hyperstimulation syndrome 23.53 10.43 3 754600 3568 78986217
Eyelid ptosis 23.32 10.43 43 754560 11001 78978784
Vision blurred 23.31 10.43 794 753809 105104 78884681
Decubitus ulcer 23.28 10.43 239 754364 15448 78974337
Coeliac disease 23.26 10.43 45 754558 11306 78978479
Change of bowel habit 23.23 10.43 68 754535 2689 78987096
Catheter site haemorrhage 23.17 10.43 103 754500 5014 78984771
Multiple drug therapy 23.14 10.43 88 754515 3990 78985795
Device pacing issue 23.12 10.43 15 754588 121 78989664
Weight decreased 23.06 10.43 2976 751627 352222 78637563
Hyperthyroidism 23.06 10.43 316 754287 21893 78967892
Atrial septal defect repair 23.05 10.43 25 754578 435 78989350
Amyloidosis 23.05 10.43 67 754536 2639 78987146
Finger deformity 23.04 10.43 22 754581 7452 78982333
Nodal arrhythmia 23.00 10.43 55 754548 1923 78987862
Hallucination, auditory 22.97 10.43 109 754494 20584 78969201
Therapeutic embolisation 22.91 10.43 26 754577 477 78989308
Hyperaesthesia 22.90 10.43 51 754552 12171 78977614
Respiratory depression 22.89 10.43 160 754443 27470 78962315
Transplant evaluation 22.85 10.43 50 754553 1647 78988138
Haemorrhagic diathesis 22.84 10.43 116 754487 5968 78983817
Catheter site discharge 22.78 10.43 62 754541 2350 78987435
Bladder cancer 22.77 10.43 101 754502 19425 78970360
Blood pressure systolic abnormal 22.76 10.43 85 754518 17162 78972623
Adverse reaction 22.72 10.43 33 754570 9281 78980504
Heart sounds abnormal 22.54 10.43 45 754558 1388 78988397
Disseminated intravascular coagulation 22.51 10.43 470 754133 35372 78954413
Sickle cell anaemia with crisis 22.51 10.43 25 754578 7897 78981888
Metastases to bone 22.49 10.43 137 754466 24290 78965495
Tension headache 22.49 10.43 21 754582 7190 78982595
Pulmonary hypertensive crisis 22.44 10.43 22 754581 338 78989447
Obesity 22.44 10.43 218 754385 34907 78954878
Drug level decreased 22.43 10.43 66 754537 14336 78975449
Cardiac cirrhosis 22.41 10.43 18 754585 209 78989576
Gastrointestinal angiodysplasia 22.41 10.43 38 754565 1031 78988754
Uraemic encephalopathy 22.38 10.43 30 754573 657 78989128
Haemorrhagic stroke 22.36 10.43 180 754423 10866 78978919
Graft versus host disease in skin 22.32 10.43 15 754588 6058 78983727
Product substitution issue 22.30 10.43 107 754496 20149 78969636
Salivary hypersecretion 22.29 10.43 65 754538 14159 78975626
Hypertension 22.12 10.43 2768 751835 328224 78661561
Drug-induced liver injury 22.09 10.43 467 754136 65650 78924135
Intraocular pressure increased 22.08 10.43 33 754570 9172 78980613
Drug level increased 22.06 10.43 511 754092 39140 78950645
Pulmonary arterial pressure abnormal 22.06 10.43 31 754572 711 78989074
Catheterisation cardiac 22.06 10.43 110 754493 5618 78984167
Abscess 22.05 10.43 127 754476 22824 78966961
Burning sensation 22.05 10.43 406 754197 58226 78931559
Foot fracture 22 10.43 120 754483 21861 78967924
Cardioversion 21.93 10.43 56 754547 2042 78987743
Anaphylactic shock 21.92 10.43 226 754377 35770 78954015
Affect lability 21.91 10.43 46 754557 11213 78978572
Drug tolerance 21.89 10.43 30 754573 8645 78981140
Hypoproteinaemia 21.88 10.43 86 754517 3960 78985825
Right ventricular dilatation 21.80 10.43 53 754550 1873 78987912
Transplant rejection 21.80 10.43 102 754501 19335 78970450
JC virus infection 21.76 10.43 5 754598 3876 78985909
Blood glucose decreased 21.69 10.43 359 754244 25875 78963910
Mitral valve calcification 21.68 10.43 45 754558 1428 78988357
Graft versus host disease in gastrointestinal tract 21.67 10.43 17 754586 6339 78983446
Body temperature decreased 21.61 10.43 197 754406 31948 78957837
Viral mutation identified 21.57 10.43 5 754598 3853 78985932
Contusion 21.55 10.43 1169 753434 147607 78842178
Tongue oedema 21.55 10.43 128 754475 6989 78982796
Gastrointestinal toxicity 21.53 10.43 27 754576 8082 78981703
Cholecystitis chronic 21.43 10.43 38 754565 9868 78979917
Cognitive disorder 21.43 10.43 837 753766 69089 78920696
Middle insomnia 21.33 10.43 79 754524 15990 78973795
Hyperaldosteronism 21.33 10.43 24 754579 436 78989349
Continuous haemodiafiltration 21.27 10.43 54 754549 1962 78987823
Aspergillus infection 21.22 10.43 101 754502 19060 78970725
Right atrial hypertrophy 21.14 10.43 31 754572 740 78989045
Optic neuritis 21.07 10.43 36 754567 9484 78980301
Carpal tunnel syndrome 21.01 10.43 104 754499 19424 78970361
Right ventricular enlargement 21.00 10.43 29 754574 654 78989131
Nail disorder 20.97 10.43 51 754552 11801 78977984
Rheumatoid lung 20.94 10.43 7 754596 4238 78985547
Hyperprolactinaemia 20.92 10.43 9 754594 4667 78985118
Glomerular filtration rate 20.91 10.43 15 754588 145 78989640
Thrombocytopenic purpura 20.91 10.43 61 754542 2408 78987377
Ureteric rupture 20.90 10.43 7 754596 7 78989778
Oxygen therapy 20.88 10.43 66 754537 2724 78987061
Nocturnal dyspnoea 20.87 10.43 47 754556 1579 78988206
Catheter site pruritus 20.76 10.43 58 754545 2233 78987552
Petechiae 20.70 10.43 291 754312 20274 78969511
Surgery 20.66 10.43 204 754399 32562 78957223
Reversible airways obstruction 20.62 10.43 56 754547 2120 78987665
Lethargy 20.62 10.43 954 753649 80338 78909447
Rectal prolapse 20.59 10.43 56 754547 2122 78987663
Pulmonary vein stenosis 20.50 10.43 15 754588 150 78989635
End stage renal disease 20.49 10.43 191 754412 12029 78977756
Pulmonary veno-occlusive disease 20.45 10.43 47 754556 1601 78988184
Emotional distress 20.39 10.43 509 754094 39460 78950325
Foetal exposure during pregnancy 20.36 10.43 15 754588 5775 78984010
Cardiac tamponade 20.35 10.43 154 754449 9122 78980663
Blood pressure diastolic increased 20.30 10.43 70 754533 14472 78975313
Bundle branch block 20.26 10.43 46 754557 1554 78988231
Penis injury 20.24 10.43 14 754589 127 78989658
Enuresis 20.14 10.43 3 754600 3173 78986612
Bone marrow failure 20.13 10.43 351 754252 50756 78939029
Human herpesvirus 6 infection 20.09 10.43 13 754590 5357 78984428
Blood urea abnormal 20.07 10.43 41 754562 1286 78988499
Hypertensive heart disease 20.06 10.43 86 754517 4120 78985665
Cardiovascular insufficiency 20.04 10.43 68 754535 2913 78986872
Blood uric acid increased 20.04 10.43 204 754399 13156 78976629
Alveolar lung disease 20.04 10.43 26 754577 551 78989234
Duodenal ulcer 19.99 10.43 240 754363 16129 78973656
Hypertrophic cardiomyopathy 19.99 10.43 58 754545 2282 78987503
Scleroderma 19.95 10.43 104 754499 5406 78984379
Lower limb fracture 19.94 10.43 133 754470 23082 78966703
Ear pruritus 19.93 10.43 7 754596 4108 78985677
Complication of device removal 19.92 10.43 6 754597 3883 78985902
Tuberculin test positive 19.90 10.43 4 754599 3404 78986381
Hepatitis B 19.86 10.43 30 754573 8302 78981483
Caesarean section 19.85 10.43 57 754546 12478 78977307
Cardiac operation 19.83 10.43 97 754506 4915 78984870
Exostosis 19.78 10.43 87 754516 16771 78973014
Ataxia 19.77 10.43 147 754456 24892 78964893
Eye infection 19.77 10.43 53 754550 11867 78977918
Weight increased 19.75 10.43 2310 752293 275076 78714709
Localised oedema 19.74 10.43 136 754467 7816 78981969
Hepatitis fulminant 19.72 10.43 127 754476 7135 78982650
Vaginal discharge 19.66 10.43 25 754578 7438 78982347
Blood bicarbonate increased 19.64 10.43 40 754563 1252 78988533
Priapism 19.63 10.43 9 754594 4496 78985289
Electrocardiogram T wave peaked 19.57 10.43 34 754569 941 78988844
Marasmus 19.54 10.43 35 754568 993 78988792
Stevens-Johnson syndrome 19.46 10.43 497 754106 38669 78951116
Onychomycosis 19.44 10.43 30 754573 8231 78981554
Pickwickian syndrome 19.32 10.43 23 754580 445 78989340
Osteonecrosis of jaw 19.31 10.43 290 754313 42936 78946849
Acute motor-sensory axonal neuropathy 19.24 10.43 22 754581 407 78989378
Renal cyst haemorrhage 19.23 10.43 28 754575 664 78989121
Pulmonary alveolar haemorrhage 19.17 10.43 179 754424 11278 78978507
Abdominal wall haemorrhage 19.17 10.43 28 754575 666 78989119
Body temperature increased 19.16 10.43 300 754303 44120 78945665
Sensitivity to weather change 19.15 10.43 29 754574 8018 78981767
Cardiopulmonary failure 19.13 10.43 120 754483 6681 78983104
Aspartate aminotransferase increased 19.12 10.43 1542 753061 137099 78852686
Ear congestion 19.11 10.43 66 754537 2853 78986932
Carotid artery thrombosis 19.10 10.43 3 754600 3050 78986735
Cardiospasm 19.02 10.43 4 754599 3297 78986488
Infected skin ulcer 18.97 10.43 73 754530 3328 78986457
Scrotal swelling 18.87 10.43 36 754567 1073 78988712
Intestinal stenosis 18.85 10.43 6 754597 3748 78986037
Heart disease congenital 18.84 10.43 26 754577 586 78989199
Metastases to lung 18.82 10.43 98 754505 18065 78971720
Urine potassium increased 18.81 10.43 7 754596 12 78989773
Lymphorrhoea 18.81 10.43 14 754589 144 78989641
Skin toxicity 18.80 10.43 31 754572 8283 78981502
Sinus arrest 18.80 10.43 76 754527 3546 78986239
Implantable defibrillator insertion 18.71 10.43 34 754569 976 78988809
Diabetic foot 18.68 10.43 76 754527 3556 78986229
Hypophysitis 18.66 10.43 8 754595 4158 78985627
Carbon dioxide increased 18.64 10.43 55 754548 2185 78987600
Post procedural haematoma 18.48 10.43 58 754545 2384 78987401
Haemorrhagic disorder 18.48 10.43 44 754559 1534 78988251
Hypoperfusion 18.45 10.43 61 754542 2578 78987207
Cardiac ablation 18.44 10.43 55 754548 2198 78987587
Inability to afford medication 18.42 10.43 63 754540 2710 78987075
Haemoconcentration 18.41 10.43 15 754588 178 78989607
Hydrothorax 18.36 10.43 42 754561 1426 78988359
Oedema due to renal disease 18.35 10.43 5 754598 0 78989785
Melanoderma 18.34 10.43 21 754582 389 78989396
Premature labour 18.32 10.43 32 754571 8358 78981427
Portal hypertensive gastropathy 18.29 10.43 41 754562 1373 78988412
Device deployment issue 18.28 10.43 4 754599 3208 78986577
Fistula 18.26 10.43 62 754541 12878 78976907
Eye disorder 18.22 10.43 138 754465 23274 78966511
Renal artery thrombosis 18.14 10.43 23 754580 476 78989309
Dermatitis allergic 18.13 10.43 99 754504 18031 78971754
Bone cyst 18.13 10.43 5 754598 3428 78986357
Heart transplant 18.11 10.43 42 754561 1439 78988346
Anal fissure 18.10 10.43 28 754575 7675 78982110
X-ray abnormal 18.05 10.43 17 754586 5796 78983989
Transferrin saturation decreased 18.04 10.43 36 754567 1110 78988675
Urine calcium decreased 18.03 10.43 8 754595 26 78989759
Oesophageal variceal ligation 18.01 10.43 13 754590 127 78989658
Dermatitis atopic 18.00 10.43 43 754560 10013 78979772
Female genital tract fistula 17.94 10.43 18 754585 5957 78983828
Hyperbilirubinaemia 17.93 10.43 329 754274 24189 78965596
Aplastic anaemia 17.87 10.43 253 754350 17652 78972133
Sinus arrhythmia 17.74 10.43 52 754551 2058 78987727
Catheter site erythema 17.68 10.43 97 754506 5143 78984642
Dizziness postural 17.64 10.43 177 754426 11372 78978413
Alcohol poisoning 17.60 10.43 12 754591 4809 78984976
Injection site discolouration 17.59 10.43 28 754575 7586 78982199
Intervertebral disc protrusion 17.56 10.43 141 754462 23480 78966305
Body temperature fluctuation 17.56 10.43 7 754596 3800 78985985
Aortic dilatation 17.54 10.43 47 754556 1765 78988020
Basilar artery occlusion 17.50 10.43 15 754588 192 78989593
Cardiac death 17.48 10.43 43 754560 1531 78988254
Alcohol abuse 17.47 10.43 15 754588 5348 78984437
Incorrect dose administered by device 17.45 10.43 13 754590 4976 78984809
Meningitis aseptic 17.44 10.43 24 754579 6904 78982881
Urinary retention 17.39 10.43 678 753925 55952 78933833
Peritoneal dialysis 17.38 10.43 30 754573 826 78988959
Diabetic metabolic decompensation 17.36 10.43 70 754533 3262 78986523
Mucous stools 17.35 10.43 14 754589 5148 78984637
Paroxysmal arrhythmia 17.33 10.43 9 754594 45 78989740
Virologic failure 17.31 10.43 9 754594 4182 78985603
Erythromelalgia 17.31 10.43 15 754588 195 78989590
Haemarthrosis 17.26 10.43 104 754499 5708 78984077
Deformity 17.25 10.43 41 754562 9564 78980221
Injection site inflammation 17.24 10.43 8 754595 3968 78985817
Phlebitis deep 17.23 10.43 7 754596 17 78989768
Tubulointerstitial nephritis 17.22 10.43 479 754124 37756 78952029
Eosinophil count increased 17.20 10.43 242 754361 16863 78972922
Tenderness 17.18 10.43 142 754461 23500 78966285
Stillbirth 17.08 10.43 8 754595 3947 78985838
Hypochromic anaemia 16.98 10.43 61 754542 2690 78987095
Euglycaemic diabetic ketoacidosis 16.94 10.43 24 754579 6820 78982965
Colitis microscopic 16.91 10.43 166 754437 10602 78979183
Haemothorax 16.89 10.43 99 754504 5379 78984406
Blood glucose increased 16.88 10.43 1285 753318 113690 78876095
Adenovirus infection 16.87 10.43 34 754569 8413 78981372
Blood creatine phosphokinase increased 16.85 10.43 776 753827 65314 78924471
Maternal exposure during breast feeding 16.84 10.43 3 754600 2782 78987003
Personality disorder 16.81 10.43 20 754583 6126 78983659
Hyperglycaemic hyperosmolar nonketotic syndrome 16.79 10.43 54 754549 2249 78987536
Lymphoproliferative disorder 16.76 10.43 17 754586 5598 78984187
Blood potassium abnormal 16.74 10.43 66 754537 3044 78986741
Myasthenia gravis 16.68 10.43 47 754556 10352 78979433
Cardioactive drug level above therapeutic 16.63 10.43 16 754587 240 78989545
Diffuse large B-cell lymphoma 16.61 10.43 59 754544 12090 78977695
Cardiac rehabilitation therapy 16.61 10.43 6 754597 9 78989776
Brain natriuretic peptide 16.58 10.43 9 754594 50 78989735
Hypokinesia 16.57 10.43 263 754340 18797 78970988
Cardiac hypertrophy 16.51 10.43 43 754560 1587 78988198
Neoplasm malignant 16.51 10.43 207 754396 31603 78958182
Linear IgA disease 16.48 10.43 66 754537 3066 78986719
Viral infection 16.44 10.43 297 754306 42719 78947066
Liver function test abnormal 16.43 10.43 757 753846 63718 78926067
Menstrual disorder 16.41 10.43 9 754594 4058 78985727
Partial seizures 16.39 10.43 38 754565 8940 78980845
Gait inability 16.38 10.43 428 754175 58489 78931296
Cirrhosis alcoholic 16.35 10.43 33 754570 1026 78988759
Hepatorenal failure 16.33 10.43 37 754566 1248 78988537
Lacrimation increased 16.33 10.43 135 754468 22342 78967443
Respiratory acidosis 16.31 10.43 170 754433 11030 78978755
Renal cancer 16.30 10.43 60 754543 12166 78977619
Intraductal papillary mucinous neoplasm 16.25 10.43 28 754575 770 78989015
Polyarthritis 16.19 10.43 60 754543 12142 78977643
Affective disorder 16.18 10.43 34 754569 8285 78981500
Status epilepticus 16.17 10.43 155 754448 24886 78964899
Bronchopulmonary aspergillosis 16.15 10.43 134 754469 22160 78967625
Wound infection 16.14 10.43 147 754456 23844 78965941
Lip swelling 16.10 10.43 281 754322 40630 78949155
Anti-neutrophil cytoplasmic antibody positive vasculitis 16.09 10.43 74 754529 3655 78986130
Pulmonary artery dilatation 16.08 10.43 21 754582 448 78989337
Tinnitus 16.04 10.43 309 754294 44024 78945761
Type I hypersensitivity 15.98 10.43 11 754592 4387 78985398
Acute myeloid leukaemia recurrent 15.97 10.43 6 754597 3377 78986408
Pneumocystis jirovecii pneumonia 15.97 10.43 214 754389 32294 78957491
Cytomegalovirus chorioretinitis 15.96 10.43 17 754586 5473 78984312
Gastrointestinal arteriovenous malformation 15.95 10.43 31 754572 937 78988848
Supraventricular extrasystoles 15.90 10.43 117 754486 6870 78982915
Neurologic neglect syndrome 15.80 10.43 4 754599 2903 78986882
Peripheral vascular disorder 15.80 10.43 130 754473 7900 78981885
Infection reactivation 15.77 10.43 3 754600 2654 78987131
Latent tuberculosis 15.74 10.43 6 754597 3347 78986438
Bleeding varicose vein 15.71 10.43 24 754579 595 78989190
Product preparation error 15.69 10.43 19 754584 5774 78984011
Normocytic anaemia 15.64 10.43 80 754523 4127 78985658
Urine output increased 15.64 10.43 52 754551 2204 78987581
Abnormal loss of weight 15.63 10.43 134 754469 8242 78981543
Gastritis haemorrhagic 15.62 10.43 58 754545 2599 78987186
Lupus pneumonitis 15.59 10.43 10 754593 79 78989706
Haemorrhoidal haemorrhage 15.58 10.43 114 754489 6681 78983104
Embolic stroke 15.56 10.43 127 754476 7699 78982086
Coronary artery occlusion 15.53 10.43 217 754386 15098 78974687
Drug specific antibody 15.52 10.43 3 754600 2625 78987160
Pulmonary haemorrhage 15.52 10.43 210 754393 14507 78975278
Overdose 15.52 10.43 1516 753087 182690 78807095
Bronchitis 15.51 10.43 1437 753166 129207 78860578
Blood creatine abnormal 15.51 10.43 13 754590 161 78989624
Spinal fusion surgery 15.48 10.43 16 754587 5222 78984563
Lipodystrophy acquired 15.47 10.43 11 754592 4314 78985471
Base excess increased 15.45 10.43 11 754592 105 78989680
Stasis dermatitis 15.42 10.43 38 754565 1355 78988430
Bipolar disorder 15.41 10.43 31 754572 7676 78982109
Supraventricular tachycardia 15.41 10.43 285 754318 20985 78968800
Tooth abscess 15.41 10.43 90 754513 16120 78973665
Attention deficit hyperactivity disorder 15.40 10.43 6 754597 3303 78986482
Hypoacusis 15.39 10.43 384 754219 29766 78960019
Wound haemorrhage 15.39 10.43 79 754524 4082 78985703
Foot operation 15.32 10.43 19 754584 5714 78984071
SARS-CoV-2 test positive 15.29 10.43 58 754545 11658 78978127
Venous pressure increased 15.29 10.43 7 754596 25 78989760
Cystostomy 15.28 10.43 10 754593 82 78989703
Cardiac resynchronisation therapy 15.27 10.43 9 754594 60 78989725
Wound complication 15.25 10.43 90 754513 4903 78984882
Nephropathy 15.24 10.43 150 754453 9588 78980197
Prohormone brain natriuretic peptide increased 15.23 10.43 16 754587 268 78989517
Coma hepatic 15.22 10.43 33 754570 1080 78988705
Myxoedema coma 15.19 10.43 26 754577 711 78989074
Loss of employment 15.18 10.43 3 754600 2584 78987201
Bone density abnormal 15.18 10.43 5 754598 3055 78986730
Prescription drug used without a prescription 15.14 10.43 10 754593 4075 78985710
Cardiac ventricular disorder 15.13 10.43 18 754585 348 78989437
Hypoprothrombinaemia 15.06 10.43 26 754577 716 78989069
Dysmenorrhoea 15.06 10.43 5 754598 3040 78986745
Cystitis haemorrhagic 15.05 10.43 41 754562 9131 78980654
Conjunctivitis 15.03 10.43 163 754440 25552 78964233
Product dose omission in error 15.00 10.43 32 754571 7756 78982029
Narrow anterior chamber angle 15 10.43 13 754590 169 78989616
Nocardiosis 14.99 10.43 19 754584 5660 78984125
Coordination abnormal 14.96 10.43 99 754504 17213 78972572
Right ventricular systolic pressure decreased 14.90 10.43 10 754593 86 78989699
White blood cell count increased 14.88 10.43 856 753747 73777 78916008
Hypokalaemic syndrome 14.87 10.43 11 754592 112 78989673
Oxygen consumption decreased 14.85 10.43 20 754583 440 78989345
Lymphocyte stimulation test positive 14.82 10.43 33 754570 1100 78988685
Angioplasty 14.80 10.43 45 754558 1818 78987967
Immune system disorder 14.79 10.43 54 754549 10975 78978810
Internal haemorrhage 14.78 10.43 138 754465 8695 78981090
Diverticulum intestinal haemorrhagic 14.73 10.43 76 754527 3935 78985850
Cyst 14.72 10.43 74 754529 13766 78976019
Atrioventricular block second degree 14.72 10.43 119 754484 7193 78982592
Nasal mucosal erosion 14.68 10.43 9 754594 65 78989720
Stroke volume decreased 14.68 10.43 4 754599 0 78989785
Hyperlactacidaemia 14.68 10.43 97 754506 5498 78984287
Euphoric mood 14.67 10.43 32 754571 7694 78982091
Aortic aneurysm 14.66 10.43 133 754470 8313 78981472
Toxic anterior segment syndrome 14.64 10.43 4 754599 2760 78987025
Electrocardiogram repolarisation abnormality 14.62 10.43 51 754552 2216 78987569
Aortic valve disease 14.60 10.43 46 754557 1895 78987890
Volume blood decreased 14.60 10.43 17 754586 321 78989464
Hepatic cancer stage IV 14.58 10.43 3 754600 2511 78987274
Blood pressure systolic increased 14.56 10.43 503 754100 66483 78923302
Encephalitis 14.54 10.43 81 754522 14679 78975106
Pneumonia aspiration 14.51 10.43 774 753829 66193 78923592
Hypercholesterolaemia 14.47 10.43 144 754459 22951 78966834
Visual field defect 14.42 10.43 41 754562 9004 78980781
Tumour lysis syndrome 14.41 10.43 312 754291 23627 78966158
Degenerative aortic valve disease 14.40 10.43 13 754590 179 78989606
Red blood cell count decreased 14.38 10.43 674 753929 56839 78932946
Blood pressure inadequately controlled 14.38 10.43 104 754499 6073 78983712
Diverticulum 14.28 10.43 209 754394 14687 78975098
Renal ischaemia 14.26 10.43 33 754570 1129 78988656
Peripheral sensory neuropathy 14.26 10.43 69 754534 12964 78976821
Sleep disorder due to a general medical condition 14.26 10.43 78 754525 14199 78975586
Hepatic hydrothorax 14.25 10.43 9 754594 69 78989716
Strangury 14.23 10.43 13 754590 182 78989603
Sacroiliitis 14.17 10.43 9 754594 3745 78986040
Erectile dysfunction 14.16 10.43 81 754522 14583 78975202
Lyme disease 14.13 10.43 7 754596 3343 78986442
Gastrointestinal pain 14.05 10.43 47 754556 9808 78979977
Vena cava injury 14.04 10.43 17 754586 335 78989450
Dry skin 14 10.43 514 754089 67481 78922304
Peritonitis 14.00 10.43 356 754247 27680 78962105
Postpericardiotomy syndrome 13.98 10.43 8 754595 50 78989735
Heart valve incompetence 13.97 10.43 65 754538 3226 78986559
Electrocardiogram U wave present 13.96 10.43 11 754592 124 78989661
Candida infection 13.94 10.43 266 754337 37948 78951837
Cytokine release syndrome 13.93 10.43 248 754355 35750 78954035
Nephrogenic systemic fibrosis 13.93 10.43 103 754500 6057 78983728
Nephropathy toxic 13.90 10.43 271 754332 20148 78969637
Palmoplantar keratoderma 13.90 10.43 9 754594 3707 78986078
Tachycardia induced cardiomyopathy 13.89 10.43 13 754590 188 78989597
Gastric varices haemorrhage 13.87 10.43 19 754584 425 78989360
Alveolitis 13.85 10.43 77 754526 4103 78985682
Enteritis 13.84 10.43 81 754522 14502 78975283
Presbyacusis 13.81 10.43 4 754599 2656 78987129
Pulmonary tuberculosis 13.79 10.43 34 754569 7831 78981954
Tremor 13.74 10.43 1404 753199 168679 78821106
Catatonia 13.73 10.43 40 754563 8716 78981069
Diabetic hyperosmolar coma 13.72 10.43 26 754577 771 78989014
Right ventricular systolic pressure increased 13.71 10.43 29 754574 933 78988852
Skin turgor decreased 13.70 10.43 26 754577 772 78989013
Diverticulum intestinal 13.68 10.43 133 754470 8472 78981313
Normal newborn 13.67 10.43 29 754574 7043 78982742
Sensory disturbance 13.65 10.43 85 754518 14992 78974793
Haemorrhagic arteriovenous malformation 13.61 10.43 22 754581 573 78989212
Incision site pain 13.60 10.43 58 754545 2772 78987013
Endophthalmitis 13.60 10.43 25 754578 6403 78983382
Pain in jaw 13.57 10.43 550 754053 45601 78944184
Ventricular dyskinesia 13.57 10.43 18 754585 390 78989395
Skin lesion 13.56 10.43 297 754306 41547 78948238
Portopulmonary hypertension 13.54 10.43 12 754591 161 78989624
Agonal rhythm 13.54 10.43 9 754594 76 78989709
Epilepsy 13.53 10.43 289 754314 40571 78949214
Blindness 13.52 10.43 188 754415 28195 78961590
Femoral artery aneurysm 13.51 10.43 13 754590 195 78989590
Pulmonary function test abnormal 13.50 10.43 76 754527 4068 78985717
Sneezing 13.50 10.43 120 754483 19563 78970222
Renal atrophy 13.50 10.43 43 754560 1782 78988003
Reversible cerebral vasoconstriction syndrome 13.49 10.43 6 754597 3051 78986734
Arteriovenous malformation 13.49 10.43 42 754561 1719 78988066
Osteopenia 13.48 10.43 110 754493 18254 78971531
Periorbital haematoma 13.46 10.43 29 754574 945 78988840
Macular degeneration 13.43 10.43 58 754545 11238 78978547
Skin necrosis 13.43 10.43 108 754495 17979 78971806
Therapy interrupted 13.41 10.43 212 754391 31129 78958656
Papilloedema 13.40 10.43 24 754579 6209 78983576
Bifascicular block 13.40 10.43 17 754586 352 78989433
Bilirubin conjugated increased 13.32 10.43 94 754509 5445 78984340
Rectal ulcer haemorrhage 13.27 10.43 15 754588 274 78989511
Cardiac failure high output 13.27 10.43 16 754587 314 78989471
Disseminated tuberculosis 13.26 10.43 12 754591 4171 78985614
Adjustment disorder 13.26 10.43 11 754592 3989 78985796
Hyperparathyroidism primary 13.26 10.43 19 754584 444 78989341
Metastases to lymph nodes 13.23 10.43 52 754551 10345 78979440
Catheter removal 13.20 10.43 23 754580 638 78989147
PO2 abnormal 13.19 10.43 6 754597 21 78989764
Bleeding time prolonged 13.19 10.43 34 754569 1247 78988538
Left atrial dilatation 13.19 10.43 62 754541 3091 78986694
Tongue dry 13.18 10.43 32 754571 1130 78988655
Dependence on oxygen therapy 13.16 10.43 21 754582 541 78989244
Cystitis 13.14 10.43 389 754214 52343 78937442
Oesophageal carcinoma 13.13 10.43 57 754546 11027 78978758
Device related infection 13.11 10.43 421 754182 33873 78955912
Seasonal allergy 13.11 10.43 96 754507 16310 78973475
Metastases to meninges 13.09 10.43 9 754594 3592 78986193
Soft tissue mass 13.07 10.43 34 754569 1254 78988531
Herpes simplex 13.06 10.43 65 754538 12122 78977663
Fine motor skill dysfunction 13.05 10.43 19 754584 5338 78984447
Injection site nodule 13.03 10.43 10 754593 3770 78986015
Diaphragmatic paralysis 13.02 10.43 31 754572 1081 78988704
Psychiatric decompensation 13.01 10.43 11 754592 3952 78985833
Haemodynamic instability 12.98 10.43 234 754369 17148 78972637
Tic 12.96 10.43 6 754597 2980 78986805
Troponin I increased 12.95 10.43 83 754520 4655 78985130
Diabetes with hyperosmolarity 12.95 10.43 5 754598 10 78989775
Cardiac asthma 12.93 10.43 15 754588 282 78989503
Glomerulonephritis acute 12.93 10.43 15 754588 282 78989503
Gastrointestinal inflammation 12.93 10.43 33 754570 7511 78982274
Pain of skin 12.92 10.43 83 754520 14530 78975255
Bladder pain 12.90 10.43 50 754553 2287 78987498
Lymphadenitis 12.89 10.43 15 754588 4640 78985145
Dizziness 12.89 10.43 5343 749260 521098 78468687
Hypertensive cardiomyopathy 12.88 10.43 16 754587 324 78989461
Analgesic drug level increased 12.87 10.43 7 754596 3171 78986614
Muscle rigidity 12.87 10.43 123 754480 19759 78970026
Ulcer haemorrhage 12.85 10.43 97 754506 5741 78984044
Puncture site haematoma 12.85 10.43 12 754591 173 78989612
Platelet transfusion 12.85 10.43 50 754553 2292 78987493
Somatic symptom disorder 12.84 10.43 4 754599 2533 78987252
Pulmonary arterial wedge pressure increased 12.82 10.43 20 754583 505 78989280
Chest tube insertion 12.82 10.43 11 754592 141 78989644
Spinal pain 12.81 10.43 89 754514 15303 78974482
Social avoidant behaviour 12.81 10.43 16 754587 4798 78984987
Cytopenia 12.81 10.43 127 754476 20256 78969529
Base excess decreased 12.80 10.43 17 754586 369 78989416
Hypermagnesaemia 12.79 10.43 33 754570 1211 78988574
Fabry's disease 12.78 10.43 6 754597 23 78989762
Crystalluria 12.78 10.43 28 754575 923 78988862
Proctitis 12.75 10.43 26 754577 6406 78983379
Cerebral venous sinus thrombosis 12.75 10.43 3 754600 2288 78987497
Thermohypoaesthesia 12.74 10.43 10 754593 112 78989673
Drug monitoring procedure not performed 12.73 10.43 29 754574 982 78988803
Waist circumference increased 12.68 10.43 40 754563 1649 78988136
Systolic dysfunction 12.63 10.43 70 754533 3725 78986060
Creatinine urine decreased 12.63 10.43 14 754589 250 78989535
Subarachnoid haemorrhage 12.61 10.43 312 754291 24153 78965632
Coma uraemic 12.60 10.43 7 754596 41 78989744
Urine odour abnormal 12.58 10.43 102 754501 6171 78983614
Infective exacerbation of chronic obstructive airways disease 12.57 10.43 56 754547 2728 78987057
SARS-CoV-2 antibody test positive 12.55 10.43 18 754585 421 78989364
Brain abscess 12.53 10.43 17 754586 4919 78984866
Monocyte count increased 12.52 10.43 55 754548 10606 78979179
Premature rupture of membranes 12.51 10.43 12 754591 4057 78985728
Blood aldosterone increased 12.51 10.43 13 754590 215 78989570
Ejection fraction abnormal 12.51 10.43 51 754552 2389 78987396
Thyroid cancer 12.49 10.43 21 754582 5567 78984218
Penile haemorrhage 12.48 10.43 20 754583 517 78989268
Peripheral embolism 12.48 10.43 44 754559 1922 78987863
Cholangiostomy 12.47 10.43 4 754599 3 78989782
Vaginal haemorrhage 12.47 10.43 139 754464 21678 78968107
Embedded device 12.47 10.43 8 754595 3311 78986474
Brain compression 12.46 10.43 21 754582 567 78989218
Prothrombin level decreased 12.40 10.43 39 754564 1605 78988180
Portal hypertension 12.37 10.43 112 754491 6996 78982789
Onychomadesis 12.37 10.43 19 754584 5223 78984562
Hepatomegaly 12.35 10.43 249 754354 18625 78971160
Drug level below therapeutic 12.34 10.43 49 754554 9721 78980064
Electrocardiogram T wave amplitude decreased 12.34 10.43 24 754579 726 78989059
Acute graft versus host disease in intestine 12.33 10.43 12 754591 4029 78985756
Acquired haemophilia 12.33 10.43 43 754560 1868 78987917
Resting tremor 12.33 10.43 37 754566 1484 78988301
Lens dislocation 12.33 10.43 11 754592 149 78989636
Impulsive behaviour 12.32 10.43 6 754597 2894 78986891
Tracheostomy 12.32 10.43 33 754570 1239 78988546
Aortic valve sclerosis 12.32 10.43 41 754562 1739 78988046
Splenic injury 12.29 10.43 14 754589 258 78989527
Deafness bilateral 12.27 10.43 47 754556 2138 78987647
Endometriosis 12.27 10.43 10 754593 3658 78986127
Ventricular failure 12.26 10.43 20 754583 525 78989260
Ketoacidosis 12.23 10.43 36 754567 7818 78981967
Sodium retention 12.21 10.43 12 754591 185 78989600
Cardiothoracic ratio increased 12.19 10.43 8 754595 66 78989719
Drug abuser 12.18 10.43 24 754579 5989 78983796
Renal vessel disorder 12.18 10.43 15 754588 301 78989484
Lymphoma 12.18 10.43 106 754497 17354 78972431
Abnormal dreams 12.15 10.43 61 754542 11351 78978434
Blood test abnormal 12.14 10.43 108 754495 17602 78972183
Brain scan abnormal 12.12 10.43 32 754571 1191 78988594
Urethral haemorrhage 12.09 10.43 17 754586 390 78989395
Facial bones fracture 12.08 10.43 86 754517 4996 78984789
Lymphoid tissue hypoplasia 12.07 10.43 27 754576 903 78988882
Facial pain 12.04 10.43 68 754535 12282 78977503
Cytomegalovirus colitis 12.03 10.43 16 754587 4669 78985116
Urine osmolarity decreased 11.98 10.43 9 754594 94 78989691
QRS axis abnormal 11.97 10.43 45 754558 2029 78987756
Suicidal behaviour 11.96 10.43 8 754595 3239 78986546
ECG signs of myocardial ischaemia 11.95 10.43 16 754587 350 78989435
Traumatic haematoma 11.94 10.43 45 754558 2031 78987754
Pericardial fibrosis 11.92 10.43 11 754592 156 78989629
Aortic valve calcification 11.90 10.43 24 754579 746 78989039
Psychomotor hyperactivity 11.88 10.43 102 754501 16747 78973038
Erythema nodosum 11.86 10.43 20 754583 5297 78984488
Upper respiratory tract inflammation 11.85 10.43 72 754531 3963 78985822
Posterior reversible encephalopathy syndrome 11.85 10.43 176 754427 26105 78963680
Epicondylitis 11.83 10.43 3 754600 2175 78987610
Arthrodesis 11.82 10.43 4 754599 2403 78987382
Stress 11.81 10.43 624 753979 78988 78910797
Femoral pulse decreased 11.81 10.43 5 754598 14 78989771
Cardio-respiratory distress 11.75 10.43 14 754589 271 78989514
Acid base balance abnormal 11.75 10.43 16 754587 356 78989429
Catheter site rash 11.75 10.43 28 754575 977 78988808
Hypogammaglobulinaemia 11.73 10.43 73 754530 12878 78976907
Cerebral artery embolism 11.73 10.43 42 754561 1849 78987936
Obsessive-compulsive disorder 11.72 10.43 24 754579 5903 78983882
Tooth disorder 11.71 10.43 176 754427 26057 78963728
Peripheral ischaemia 11.70 10.43 139 754464 9318 78980467
Thyroxine free decreased 11.69 10.43 29 754574 1038 78988747
Inguinal hernia 11.69 10.43 103 754500 6385 78983400
Immunosuppression 11.69 10.43 72 754531 12731 78977054
Inferior vena cava syndrome 11.68 10.43 9 754594 98 78989687
Vascular anastomotic haemorrhage 11.68 10.43 14 754589 273 78989512
Tetany 11.67 10.43 54 754549 2674 78987111
Abdominal pain lower 11.66 10.43 221 754382 31561 78958224
Allergy to chemicals 11.65 10.43 5 754598 2597 78987188
Extradural haematoma 11.62 10.43 56 754547 2820 78986965
Hyperammonaemic encephalopathy 11.61 10.43 17 754586 4765 78985020
Oesophageal perforation 11.60 10.43 37 754566 1534 78988251
Humerus fracture 11.57 10.43 137 754466 9176 78980609
Blood lactate dehydrogenase increased 11.57 10.43 467 754136 38703 78951082
Endometriosis male 11.56 10.43 5 754598 15 78989770
Systemic scleroderma 11.54 10.43 31 754572 1166 78988619
Gastric antral vascular ectasia 11.53 10.43 27 754576 931 78988854
Urine chloride decreased 11.53 10.43 9 754594 100 78989685
Pulmonary interstitial emphysema syndrome 11.51 10.43 19 754584 504 78989281
Renal hypertrophy 11.48 10.43 7 754596 50 78989735
Right atrial pressure increased 11.48 10.43 14 754589 278 78989507
Calcification metastatic 11.48 10.43 10 754593 131 78989654
Vaginal infection 11.46 10.43 24 754579 5856 78983929
Chest injury 11.45 10.43 55 754548 2766 78987019
Biopsy liver 11.45 10.43 21 754582 607 78989178
Shoshin beriberi 11.44 10.43 8 754595 74 78989711
Left ventricular end-diastolic pressure increased 11.44 10.43 22 754581 660 78989125
Cutaneous vasculitis 11.43 10.43 124 754479 8128 78981657
Mucosal dryness 11.42 10.43 65 754538 3494 78986291
Histoplasmosis disseminated 11.40 10.43 4 754599 2349 78987436
Procedural haemorrhage 11.40 10.43 80 754523 4626 78985159
Gastric haemorrhage 11.37 10.43 203 754400 14847 78974938
Major depression 11.37 10.43 45 754558 8935 78980850
Pulmonary valve incompetence 11.36 10.43 42 754561 1878 78987907
Sight disability 11.36 10.43 10 754593 133 78989652
Cheyne-Stokes respiration 11.35 10.43 19 754584 510 78989275
Peritoneal cloudy effluent 11.35 10.43 15 754588 324 78989461
Ocular icterus 11.34 10.43 90 754513 5410 78984375
Ectopic gastric mucosa 11.33 10.43 5 754598 16 78989769
Electrocardiogram QRS complex abnormal 11.31 10.43 21 754582 613 78989172
Large intestinal polypectomy 11.31 10.43 15 754588 325 78989460
Hepatitis C 11.31 10.43 167 754436 11758 78978027
Cystic fibrosis 11.30 10.43 12 754591 3868 78985917
Bradyphrenia 11.29 10.43 152 754451 10488 78979297
Pulse pressure decreased 11.29 10.43 17 754586 416 78989369
Injection site extravasation 11.28 10.43 50 754553 9619 78980166
Mouth haemorrhage 11.28 10.43 155 754448 10744 78979041
Dactylitis 11.27 10.43 6 754597 2751 78987034
Rash morbilliform 11.27 10.43 98 754505 6052 78983733
Thymus hypoplasia 11.26 10.43 27 754576 946 78988839
Craniocerebral injury 11.25 10.43 86 754517 5110 78984675
Clostridium difficile colitis 11.24 10.43 392 754211 31891 78957894
Renal tubular disorder 11.19 10.43 102 754501 6384 78983401
Renal embolism 11.17 10.43 11 754592 170 78989615
Metastases to central nervous system 11.16 10.43 100 754503 16275 78973510
Wheelchair user 11.15 10.43 26 754577 6106 78983679
Therapeutic reaction time decreased 11.15 10.43 10 754593 3491 78986294
Fibrin degradation products increased 11.13 10.43 16 754587 375 78989410
Metastatic renal cell carcinoma 11.12 10.43 48 754555 2307 78987478
Tendon pain 11.11 10.43 23 754580 5635 78984150
Blood zinc decreased 11.10 10.43 5 754598 17 78989768
Hostility 11.07 10.43 4 754599 2306 78987479
Accidental exposure to product by child 11.06 10.43 7 754596 2919 78986866
Hypertensive crisis 11.04 10.43 266 754337 20504 78969281
Personality change 11.04 10.43 54 754549 10116 78979669
Catheter site irritation 11.03 10.43 20 754583 573 78989212
Malnutrition 11.02 10.43 285 754318 22217 78967568
Keratitis viral 11.01 10.43 3 754600 0 78989785
Blood creatine 11.01 10.43 3 754600 0 78989785
Tongue amyloidosis 11.01 10.43 3 754600 0 78989785
Skin weeping 11.00 10.43 28 754575 1019 78988766
Blood chloride increased 10.98 10.43 85 754518 5071 78984714
Dyskinesia 10.97 10.43 331 754272 44442 78945343
Diagnostic procedure 10.97 10.43 11 754592 174 78989611
Device inappropriate shock delivery 10.94 10.43 7 754596 55 78989730
Dysgeusia 10.94 10.43 436 754167 56741 78933044
Galactorrhoea 10.93 10.43 11 754592 3635 78986150
Agitation 10.89 10.43 804 753799 98911 78890874
Vascular resistance systemic decreased 10.88 10.43 12 754591 213 78989572
Disability assessment scale score increased 10.87 10.43 10 754593 3448 78986337
Upper motor neurone lesion 10.86 10.43 13 754590 253 78989532
Lip erosion 10.86 10.43 36 754567 1524 78988261
Small intestinal haemorrhage 10.82 10.43 72 754531 4091 78985694
Electrocardiogram QT shortened 10.79 10.43 12 754591 215 78989570
Procedural failure 10.77 10.43 8 754595 82 78989703
Benign prostatic hyperplasia 10.77 10.43 162 754441 11450 78978335
Bezoar 10.77 10.43 6 754597 2682 78987103
Wrong strength 10.77 10.43 11 754592 178 78989607
International normalised ratio 10.77 10.43 9 754594 111 78989674
Perineal cyst 10.74 10.43 13 754590 256 78989529
Haemorrhoids 10.72 10.43 356 754247 28772 78961013
Plasmacytosis 10.72 10.43 10 754593 144 78989641
Cystatin C increased 10.69 10.43 5 754598 19 78989766
Skin papilloma 10.67 10.43 25 754578 5861 78983924
Intraventricular haemorrhage 10.65 10.43 81 754522 4806 78984979
Haemorrhagic infarction 10.64 10.43 23 754580 751 78989034
Kidney small 10.63 10.43 13 754590 259 78989526
Cardiac valve replacement complication 10.62 10.43 12 754591 219 78989566
Mouth breathing 10.61 10.43 10 754593 146 78989639
Post procedural haemorrhage 10.61 10.43 186 754417 13558 78976227
Osmotic demyelination syndrome 10.60 10.43 35 754568 1478 78988307
Nasal disorder 10.59 10.43 12 754591 3757 78986028
Urinary tract candidiasis 10.58 10.43 23 754580 754 78989031
Haemorrhagic transformation stroke 10.58 10.43 52 754551 2640 78987145
Fanconi syndrome 10.57 10.43 7 754596 2849 78986936
Thalamus haemorrhage 10.56 10.43 39 754564 1743 78988042
Peripheral coldness 10.55 10.43 211 754392 15759 78974026
Arrhythmia supraventricular 10.54 10.43 44 754559 2083 78987702
Lymphocyte count decreased 10.53 10.43 354 754249 46935 78942850
Fracture 10.53 10.43 144 754459 21657 78968128
Intestinal resection 10.52 10.43 12 754591 3745 78986040
Conjunctival haemorrhage 10.51 10.43 93 754510 5772 78984013
Generalised bullous fixed drug eruption 10.48 10.43 11 754592 184 78989601
Mineral supplementation 10.47 10.43 24 754579 816 78988969
Polyneuropathy 10.45 10.43 163 754440 23988 78965797
Bundle branch block bilateral 10.45 10.43 7 754596 60 78989725
Bacterial prostatitis 10.45 10.43 7 754596 60 78989725
Mitral valve replacement 10.43 10.43 16 754587 398 78989387

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03CA01 CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Sulfonamides, plain
ATC C03CB01 CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Sulfonamides and potassium in combination
ATC C03EB01 CARDIOVASCULAR SYSTEM
DIURETICS
DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
High-ceiling diuretics and potassium-sparing agents
FDA PE N0000175366 Increased Diuresis at Loop of Henle
FDA EPC N0000175590 Loop Diuretic
MeSH PA D004232 Diuretics
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D045283 Natriuretic Agents
MeSH PA D049994 Sodium Potassium Chloride Symporter Inhibitors
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:77608 loop diuretics
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Acute pulmonary edema indication 40541001
Decompensated cardiac failure indication 195111005
Edema indication 267038008
Pulmonary Edema due to Chronic Heart Failure indication
Edema due to Hepatic Cirrhosis indication
Peripheral Edema due to Chronic Heart Failure indication
Hypercalcemia off-label use 66931009 DOID:12678
Prevention of Oliguria off-label use
Metabolic alkalosis contraindication 1388004
Anuria contraindication 2472002 DOID:2983
Hypocalcemia contraindication 5291005
Hypochloremia contraindication 10399008
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Diabetes mellitus contraindication 73211009 DOID:9351
Pancreatitis contraindication 75694006 DOID:4989
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Hearing disorder contraindication 128540005
Hypomagnesemia contraindication 190855004
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Azotemia contraindication 445009001




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Edema (pulmonary congestion, ascites) associated with cardiac insufficiency Indication
Cats Acute noninflammatory tissue edema Indication
Cattle Physiological parturient edema of the mammary gland and associated structures Indication
Dogs Edema (pulmonary congestion, ascites) associated with cardiac insufficiency Indication
Dogs Acute noninflammatory tissue edema Indication
Horses Edema (pulmonary congestion, ascites) associated with cardiac insufficiency Indication
Horses Acute noninflammatory tissue edema Indication

🐶 Veterinary products

ProductApplicantIngredients
Salix Injection 5% Intervet Inc. 1
Salix Tablets Intervet Inc. 1
Lasix Packets Intervet Inc. 1
Lasix Syrup 1% Intervet Inc. 1
Furos-A-Vet Bimeda Animal Health Limited 1
Disal Injection Boehringer lngelheim Animal Health USA Inc. 1
Disal Boehringer lngelheim Animal Health USA Inc. 1
Disal Boehringer lngelheim Animal Health USA Inc. 1
Furosemide Injection 5% Elanco US Inc. 1
Furosemide Syrup 1% First Priority Inc. 1
Furosemide Syrup 1% Cronus Pharma Specialities India Private Limited 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.69 acidic
pKa2 10.59 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
80MG/10ML (8MG/ML) FUROSCIX SCPHARMACEUTICALS N209988 Oct. 7, 2022 RX SOLUTION SUBCUTANEOUS 11433044 April 3, 2034 USE OF A LIQUID FORMULATION COMPRISING FUROSEMIDE TO TREAT CONGESTION DUE TO FLUID OVERLOAD (EDEMA) IN ADULTS WITH NYHA CLASS II/III CHRONIC HEART FAILURE
80MG/10ML (8MG/ML) FUROSCIX SCPHARMACEUTICALS N209988 Oct. 7, 2022 RX SOLUTION SUBCUTANEOUS 9884039 April 3, 2034 USE OF A LIQUID FORMULATION COMPRISING FUROSEMIDE TO TREAT CONGESTION DUE TO FLUID OVERLOAD (EDEMA) IN ADULTS WITH NYHA CLASS II/III CHRONIC HEART FAILURE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Solute carrier family 12 member 1 Transporter INHIBITOR IC50 6.20 WOMBAT-PK CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-1 Transporter WOMBAT-PK
Carbonic anhydrase 2 Enzyme Ki 7.19 CHEMBL
ATP-binding cassette sub-family G member 2 Transporter IC50 5.50 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 7.21 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 6.25 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 6.38 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 6.58 CHEMBL
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 6.30 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 6.49 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 6.29 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 6.61 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 7.28 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme IC50 5.42 CHEMBL
Solute carrier family 12 member 2 Transporter INHIBITOR IC50 5.13 IUPHAR
G-protein coupled receptor 35 GPCR Ki 5.49 CHEMBL
CDGSH iron-sulfur domain-containing protein 1 Unclassified Ki 5.64 CHEMBL
Carbonic anhydrase 13 Enzyme Ki 6.26 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme IC50 5.42 CHEMBL
Holo-[acyl-carrieir-protein] synthase Enzyme IC50 4.90 CHEMBL

External reference:

IDSource
4017830 VUID
N0000146188 NUI
D00331 KEGG_DRUG
4017830 VANDF
C0016860 UMLSCUI
CHEBI:47426 CHEBI
FUN PDB_CHEM_ID
CHEMBL35 ChEMBL_ID
CHEMBL1788133 ChEMBL_ID
DB00695 DRUGBANK_ID
D005665 MESH_DESCRIPTOR_UI
3440 PUBCHEM_CID
4839 IUPHAR_LIGAND_ID
1584 INN_ID
7LXU5N7ZO5 UNII
4603 RXNORM
3962 MMSL
4769 MMSL
d00070 MMSL
002307 NDDF
387475002 SNOMEDCT_US
81609008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-3294 SOLUTION 10 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-3294 SOLUTION 10 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-3294 SOLUTION 10 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-3298 SOLUTION 40 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-3298 SOLUTION 40 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-3298 SOLUTION 40 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4297 TABLET 20 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4297 TABLET 20 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4297 TABLET 20 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4299 TABLET 40 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4299 TABLET 40 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4299 TABLET 40 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4301 TABLET 80 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4301 TABLET 80 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4301 TABLET 80 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8297 TABLET 20 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8297 TABLET 20 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8297 TABLET 20 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8299 TABLET 40 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8299 TABLET 40 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8299 TABLET 40 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8301 TABLET 80 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8301 TABLET 80 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8301 TABLET 80 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0208 TABLET 20 mg ORAL NDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0208 TABLET 20 mg ORAL NDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0216 TABLET 40 mg ORAL NDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0216 TABLET 40 mg ORAL NDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0232 TABLET 80 mg ORAL ANDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0232 TABLET 80 mg ORAL ANDA 22 sections