furosemide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diuretics, furosemide derivatives 1258 54-31-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • frusemide
  • furosemide
  • furosemid
A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
  • Molecular weight: 330.74
  • Formula: C12H11ClN2O5S
  • CLOGP: 1.90
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 122.63
  • ALOGS: -3.45
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
40 mg O
40 mg P
40 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 66 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 25.92 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 71 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.12 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 1, 1966 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 2314.34 10.08 5994 420108 229861 46030099
Cardiac failure congestive 2122.64 10.08 3338 422764 88412 46171548
Drug ineffective 1347.13 10.08 2601 423501 675237 45584723
Cardiac failure 1319.38 10.08 2506 423596 77442 46182518
Hyperkalaemia 1132.92 10.08 1817 424285 48892 46211068
Rheumatoid arthritis 1030.26 10.08 452 425650 239763 46020197
Oedema peripheral 738.37 10.08 3150 422952 156556 46103404
Hyponatraemia 695.22 10.08 2270 423832 99062 46160898
Renal failure 667.81 10.08 2417 423685 111177 46148783
International normalised ratio increased 632.31 10.08 1352 424750 45531 46214429
Drug hypersensitivity 585.04 10.08 824 425278 243001 46016959
Dyspnoea 581.52 10.08 7214 418888 508334 45751626
Off label use 558.34 10.08 1701 424401 378140 45881820
Completed suicide 543.97 10.08 329 425773 145591 46114369
Hypokalaemia 506.16 10.08 1860 424242 86164 46173796
Atrial fibrillation 492.01 10.08 2061 424041 101529 46158431
Hypotension 467.53 10.08 3675 422427 228914 46031046
Pulmonary hypertension 465.86 10.08 1021 425081 34972 46224988
Bradycardia 462.34 10.08 1494 424608 64804 46195156
Drug interaction 450.79 10.08 3285 422817 199809 46060151
Oedema 439.60 10.08 1480 424622 65591 46194369
Anaemia 435.71 10.08 3894 422208 251885 46008075
Fluid retention 420.99 10.08 1220 424882 49826 46210134
Treatment failure 387.71 10.08 182 425920 92905 46167055
Right ventricular failure 378.90 10.08 591 425511 15502 46244458
Pemphigus 377.86 10.08 7 426095 45267 46214693
Maternal exposure during pregnancy 372.64 10.08 238 425864 102311 46157649
Drug intolerance 360.26 10.08 489 425613 146560 46113400
Pulmonary arterial hypertension 360.21 10.08 757 425345 25171 46234789
Renal impairment 354.75 10.08 1482 424620 72890 46187070
Pain 350.09 10.08 2735 423367 474213 45785747
Contraindicated product administered 349.16 10.08 146 425956 79801 46180159
Gastrointestinal haemorrhage 342.25 10.08 1507 424595 75866 46184094
Melaena 341.58 10.08 772 425330 27000 46232960
Injection site pain 333.58 10.08 292 425810 106860 46153100
Alopecia 329.83 10.08 612 425490 161802 46098158
Blood creatinine increased 313.90 10.08 1456 424646 74947 46185013
Arthralgia 305.92 10.08 2011 424091 362592 45897368
Injection site erythema 297.07 10.08 154 425948 74273 46185687
Exposure during pregnancy 288.79 10.08 337 425765 107875 46152085
Abortion spontaneous 288.36 10.08 31 426071 43615 46216345
Infusion related reaction 277.89 10.08 308 425794 100900 46159060
Lactic acidosis 277.17 10.08 808 425294 33101 46226859
Therapeutic product effect decreased 269.50 10.08 215 425887 82386 46177574
Dehydration 268.09 10.08 2423 423679 157117 46102843
Myocardial infarction 264.10 10.08 1658 424444 95870 46164090
Blood urea increased 250.90 10.08 648 425454 24704 46235256
Torsade de pointes 246.23 10.08 417 425685 11737 46248223
Hand deformity 243.27 10.08 19 426083 34555 46225405
Pulmonary oedema 239.42 10.08 1013 425089 50092 46209868
Glossodynia 238.34 10.08 56 426046 44317 46215643
Injection site reaction 231.50 10.08 74 426028 47775 46212185
Rash 224.54 10.08 2126 423976 354386 45905574
Fall 221.60 10.08 4224 421878 324873 45935087
Arthropathy 219.33 10.08 270 425832 84430 46175530
Systemic lupus erythematosus 217.23 10.08 166 425936 65014 46194946
Musculoskeletal stiffness 214.49 10.08 352 425750 97641 46162319
Syncope 210.55 10.08 1657 424445 103146 46156814
Intentional overdose 205.68 10.08 174 425928 64770 46195190
Hypoglycaemia 204.51 10.08 1010 425092 53339 46206621
Metabolic alkalosis 200.92 10.08 178 425924 2482 46257478
Device expulsion 197.01 10.08 14 426088 27528 46232432
Joint swelling 196.88 10.08 813 425289 165260 46094700
Fluid overload 195.17 10.08 619 425483 26566 46233394
Pleural effusion 190.63 10.08 1354 424748 81598 46178362
Ascites 185.39 10.08 743 425359 35841 46224119
Therapeutic product effect incomplete 183.18 10.08 268 425834 77885 46182075
Hypersensitivity 181.23 10.08 731 425371 149590 46110370
Cardioactive drug level increased 180.39 10.08 150 425952 1909 46258051
Injection site swelling 180.33 10.08 71 426031 40256 46219704
Suicide attempt 179.80 10.08 143 425959 54893 46205067
Orthostatic hypotension 176.60 10.08 561 425541 24097 46235863
Abdominal discomfort 175.45 10.08 746 425356 150419 46109541
Chronic kidney disease 169.32 10.08 781 425321 40090 46219870
Psoriasis 168.61 10.08 286 425816 78318 46181642
Injection site pruritus 168.05 10.08 76 426026 39667 46220293
Fatigue 163.99 10.08 4269 421833 604428 45655532
Rheumatoid factor positive 163.68 10.08 5 426097 20456 46239504
Sinusitis 157.06 10.08 630 425472 129138 46130822
Injection site bruising 155.67 10.08 65 426037 35571 46224389
Headache 155.41 10.08 3259 422843 475093 45784867
Haematoma 147.10 10.08 629 425473 31243 46228717
Product use issue 146.30 10.08 413 425689 94231 46165729
Rhabdomyolysis 140.37 10.08 754 425348 41155 46218805
Nausea 139.75 10.08 5006 421096 682448 45577512
Rectal haemorrhage 135.50 10.08 699 425403 37556 46222404
Cardiac failure chronic 135.35 10.08 164 425938 3360 46256600
Urticaria 134.18 10.08 586 425516 117306 46142654
Urine output decreased 132.56 10.08 305 425797 10792 46249168
Cardiac failure acute 130.26 10.08 251 425851 7827 46252133
Respiratory failure 130.16 10.08 1381 424721 93435 46166525
Electrocardiogram QT prolonged 128.67 10.08 856 425246 50469 46209491
Hepatic encephalopathy 122.25 10.08 280 425822 9877 46250083
Drug abuse 119.85 10.08 249 425853 63159 46196801
Pregnancy 119.33 10.08 49 426053 27088 46232872
Generalised oedema 118.49 10.08 344 425758 14055 46245905
Synovitis 117.85 10.08 237 425865 60838 46199122
Hypoxia 116.63 10.08 842 425260 50996 46208964
Confusional state 116.21 10.08 2078 424024 157814 46102146
Chronic obstructive pulmonary disease 111.70 10.08 904 425198 56729 46203231
Paraesthesia 110.51 10.08 624 425478 116813 46143147
Nasopharyngitis 110.08 10.08 888 425214 153110 46106850
Acute myocardial infarction 110.07 10.08 579 425523 31345 46228615
Psoriatic arthropathy 109.71 10.08 102 426000 36277 46223683
Pseudo-Bartter syndrome 108.84 10.08 35 426067 29 46259931
Anuria 108.81 10.08 288 425814 11143 46248817
Product use in unapproved indication 107.45 10.08 441 425661 89832 46170128
Ventricular tachycardia 107.18 10.08 370 425732 16597 46243363
Migraine 104.96 10.08 310 425792 69716 46190244
Pneumonia 103.11 10.08 4306 421796 372014 45887946
Transfusion 103.06 10.08 310 425792 12921 46247039
Sopor 102.28 10.08 405 425697 19423 46240537
Dyspnoea exertional 101.93 10.08 797 425305 49492 46210468
Coronary artery disease 99.61 10.08 587 425515 33165 46226795
Hepatic enzyme increased 98.31 10.08 398 425704 81389 46178571
Toxicity to various agents 98.01 10.08 1352 424750 210414 46049546
Red blood cell sedimentation rate abnormal 97.44 10.08 7 426095 13642 46246318
Multiple sclerosis relapse 97.17 10.08 146 425956 41979 46217981
Haemoglobin decreased 96.55 10.08 1684 424418 127265 46132695
Shock haemorrhagic 96.44 10.08 231 425871 8393 46251567
Multiple organ dysfunction syndrome 96.39 10.08 804 425298 50906 46209054
Febrile neutropenia 96.10 10.08 490 425612 94137 46165823
Foetal exposure during pregnancy 92.96 10.08 86 426016 30661 46229299
Orthopnoea 92.73 10.08 181 425921 5699 46254261
Depression 92.18 10.08 1050 425052 169054 46090906
Suicidal ideation 91.63 10.08 240 425862 56142 46203818
Presyncope 91.63 10.08 454 425648 24000 46235960
Toxic epidermal necrolysis 89.52 10.08 422 425680 21856 46238104
Creatinine renal clearance decreased 89.14 10.08 196 425906 6724 46253236
Nephrocalcinosis 86.67 10.08 72 426030 915 46259045
Hypernatraemia 85.53 10.08 184 425918 6217 46253743
Infective pulmonary exacerbation of cystic fibrosis 85.17 10.08 3 426099 10804 46249156
Oliguria 83.69 10.08 221 425881 8538 46251422
Cardiogenic shock 83.18 10.08 333 425769 16051 46243909
Mitral valve incompetence 83.11 10.08 367 425735 18485 46241475
Blood potassium increased 83.08 10.08 341 425761 16626 46243334
Pericarditis 82.20 10.08 59 426043 23868 46236092
Renal injury 81.47 10.08 231 425871 9310 46250650
Bradyarrhythmia 81.39 10.08 96 426006 1910 46258050
Epistaxis 80.58 10.08 920 425182 63385 46196575
Cardiac disorder 80.19 10.08 679 425423 43179 46216781
Loss of personal independence in daily activities 80.12 10.08 261 425841 56922 46203038
Subdural haematoma 79.99 10.08 281 425821 12716 46247244
Blood potassium decreased 79.78 10.08 608 425494 37455 46222505
No adverse event 78.61 10.08 119 425983 34112 46225848
Anxiety 77.40 10.08 1181 424921 180776 46079184
Acne 76.83 10.08 43 426059 19876 46240084
Cardiomegaly 76.82 10.08 340 425762 17142 46242818
Acute respiratory failure 76.68 10.08 492 425610 28646 46231314
Pericardial effusion 75.87 10.08 445 425657 25098 46234862
Brain natriuretic peptide increased 75.61 10.08 145 425957 4505 46255455
Asthenia 75.48 10.08 3516 422586 307559 45952401
Intentional product use issue 75.28 10.08 239 425863 52541 46207419
Accidental exposure to product 75.05 10.08 50 426052 21031 46238929
Acute pulmonary oedema 74.28 10.08 198 425904 7693 46252267
Atrial flutter 73.78 10.08 217 425885 8931 46251029
Hypovolaemia 73.58 10.08 228 425874 9660 46250300
Drug resistance 70.67 10.08 35 426067 17333 46242627
Insomnia 70.28 10.08 1070 425032 163854 46096106
Inappropriate schedule of product administration 69.83 10.08 330 425772 64683 46195277
Anaphylactic reaction 68.61 10.08 251 425851 52861 46207099
Wrong technique in product usage process 68.47 10.08 260 425842 54162 46205798
Hypochloraemia 68.43 10.08 85 426017 1788 46258172
Lower gastrointestinal haemorrhage 68.22 10.08 183 425919 7137 46252823
Blood sodium decreased 68.12 10.08 384 425718 21342 46238618
Blood loss anaemia 68.08 10.08 202 425900 8355 46251605
Discomfort 67.49 10.08 210 425892 46460 46213500
Hypocalcaemia 67.27 10.08 447 425655 26338 46233622
Product quality issue 65.67 10.08 142 425960 35506 46224454
Injection site warmth 65.37 10.08 22 426080 13750 46246210
Hypomagnesaemia 65.36 10.08 386 425716 21824 46238136
Intentional self-injury 64.69 10.08 75 426027 24091 46235869
Gout 64.35 10.08 239 425863 11117 46248843
Hypoaesthesia 64.25 10.08 734 425368 118135 46141825
Impaired work ability 63.91 10.08 18 426084 12618 46247342
N-terminal prohormone brain natriuretic peptide increased 63.08 10.08 78 426024 1633 46258327
Breast cancer 62.91 10.08 209 425893 45309 46214651
C-reactive protein abnormal 62.53 10.08 61 426041 21209 46238751
Pulmonary arterial pressure increased 61.84 10.08 110 425992 3222 46256738
Neutropenia 61.72 10.08 927 425175 142277 46117683
Oxygen saturation decreased 61.71 10.08 930 425172 68234 46191726
Toxic skin eruption 60.68 10.08 249 425853 12138 46247822
Injection site urticaria 60.61 10.08 17 426085 11950 46248010
Gastrointestinal disorder 60.18 10.08 309 425793 59267 46200693
Oral herpes 60.09 10.08 53 426049 19337 46240623
Hyperuricaemia 60.08 10.08 133 425969 4584 46255376
Hepatic failure 59.85 10.08 515 425587 32901 46227059
Injection site rash 59.75 10.08 35 426067 15778 46244182
Sleep disorder 59.23 10.08 223 425879 46572 46213388
Atrioventricular block 59.22 10.08 166 425936 6645 46253315
Haematemesis 58.62 10.08 457 425645 28349 46231611
Iron deficiency anaemia 58.57 10.08 311 425791 16895 46243065
Hypovolaemic shock 58.14 10.08 139 425963 5044 46254916
Colitis ulcerative 57.99 10.08 46 426056 17686 46242274
Ventricular fibrillation 57.83 10.08 233 425869 11263 46248697
Blood pressure decreased 57.53 10.08 785 425317 56374 46203586
Prerenal failure 57.03 10.08 68 426034 1369 46258591
Multiple sclerosis 56.13 10.08 87 426015 24704 46235256
Asthma 56.05 10.08 549 425553 90993 46168967
Haemodialysis 55.62 10.08 198 425904 9019 46250941
Upper gastrointestinal haemorrhage 55.25 10.08 300 425802 16438 46243522
Intra-abdominal haematoma 54.81 10.08 71 426031 1560 46258400
Peripheral swelling 54.19 10.08 1855 424247 156216 46103744
Oropharyngeal pain 54.18 10.08 425 425677 73743 46186217
Cor pulmonale 53.80 10.08 77 426025 1866 46258094
Musculoskeletal pain 53.51 10.08 397 425705 69731 46190229
Ovarian cyst 53.49 10.08 31 426071 14056 46245904
Hepatic cirrhosis 53.31 10.08 284 425818 15448 46244512
Atrioventricular block complete 53.21 10.08 172 425930 7455 46252505
Cerebrovascular accident 53.12 10.08 1252 424850 99787 46160173
Psychotic disorder 52.56 10.08 78 426024 22543 46237417
Seizure 52.18 10.08 799 425303 122255 46137705
Respiratory distress 52.08 10.08 482 425620 31434 46228526
Device difficult to use 52.06 10.08 6 426096 7998 46251962
Hip arthroplasty 52.03 10.08 53 426049 18059 46241901
Left ventricular failure 51.90 10.08 130 425972 4860 46255100
Mucosal inflammation 51.80 10.08 182 425920 38794 46221166
Red blood cell sedimentation rate increased 51.18 10.08 81 426021 22808 46237152
Uterine perforation 51.10 10.08 4 426098 7263 46252697
Pharyngitis 51.03 10.08 51 426051 17532 46242428
Influenza like illness 50.87 10.08 312 425790 57258 46202702
Pemphigoid 50.76 10.08 140 425962 5551 46254409
Gestational diabetes 50.69 10.08 4 426098 7215 46252745
Device issue 50.32 10.08 65 426037 19915 46240045
Joint stiffness 49.91 10.08 108 425994 27000 46232960
Electrolyte imbalance 49.80 10.08 298 425804 16928 46243032
Cardiac output decreased 49.77 10.08 51 426051 861 46259099
Therapeutic response decreased 49.32 10.08 214 425888 42931 46217029
Blood bilirubin increased 49.27 10.08 503 425599 33681 46226279
Shock 49.21 10.08 355 425747 21490 46238470
Muscle haemorrhage 48.85 10.08 99 426003 3205 46256755
Cellulitis 48.70 10.08 907 425195 69381 46190579
Prothrombin time prolonged 47.88 10.08 194 425908 9402 46250558
Adverse drug reaction 47.74 10.08 225 425877 44137 46215823
Cardiomyopathy 47.72 10.08 280 425822 15793 46244167
Dialysis 47.71 10.08 201 425901 9915 46250045
Renal disorder 47.64 10.08 411 425691 26275 46233685
Aortic stenosis 47.52 10.08 116 425986 4266 46255694
Pyrexia 46.85 10.08 2655 423447 346147 45913813
Congestive hepatopathy 46.72 10.08 82 426020 2376 46257584
Arrhythmia 46.61 10.08 505 425597 34336 46225624
Sepsis 46.06 10.08 1594 424508 134420 46125540
Progressive multifocal leukoencephalopathy 45.96 10.08 23 426079 11323 46248637
Night sweats 45.80 10.08 114 425988 27136 46232824
Wound 45.52 10.08 218 425884 42584 46217376
Osteoporosis 44.26 10.08 205 425897 40403 46219557
Pulmonary congestion 44.06 10.08 258 425844 14541 46245419
Mood swings 43.97 10.08 50 426052 16202 46243758
Ischaemic stroke 43.77 10.08 282 425820 16440 46243520
Basal cell carcinoma 43.48 10.08 75 426027 20412 46239548
Product dose omission issue 43.41 10.08 1188 424914 167332 46092628
Sudden death 43.40 10.08 187 425915 9317 46250643
Abdominal wall haematoma 43.40 10.08 87 426015 2794 46257166
Pain in extremity 43.21 10.08 1925 424177 256755 46003205
Concomitant disease aggravated 43.09 10.08 164 425938 7718 46252242
Haemoptysis 42.97 10.08 396 425706 25793 46234167
Gastrointestinal tract mucosal pigmentation 42.20 10.08 38 426064 542 46259418
Ischaemic cardiomyopathy 41.96 10.08 81 426021 2529 46257431
Azotaemia 41.79 10.08 110 425992 4241 46255719
Nodal rhythm 41.50 10.08 64 426038 1661 46258299
Duodenal ulcer perforation 41.38 10.08 13 426089 8489 46251471
Blood alkaline phosphatase increased 41.10 10.08 547 425555 39062 46220898
Congestive cardiomyopathy 40.91 10.08 130 425972 5583 46254377
Chest pain 40.54 10.08 1983 424119 174341 46085619
Dilatation ventricular 40.46 10.08 79 426023 2488 46257472
Catheter management 40.44 10.08 83 426019 2712 46257248
Throat irritation 40.41 10.08 132 425970 28769 46231191
Infection 40.28 10.08 920 425182 132672 46127288
Cardiac pacemaker insertion 40.20 10.08 98 426004 3601 46256359
Rheumatoid nodule 40.12 10.08 16 426086 9004 46250956
Tricuspid valve incompetence 40.10 10.08 238 425864 13479 46246481
Device dislocation 40.02 10.08 87 426015 21715 46238245
Bone erosion 40.00 10.08 18 426084 9425 46250535
International normalised ratio abnormal 39.81 10.08 87 426015 2972 46256988
Drug ineffective for unapproved indication 39.70 10.08 55 426047 16358 46243602
Glomerular filtration rate decreased 38.87 10.08 210 425892 11484 46248476
Injection site mass 38.84 10.08 48 426054 14992 46244968
Eye pain 38.80 10.08 128 425974 27812 46232148
Haematotoxicity 38.74 10.08 8 426094 6925 46253035
Coeliac disease 38.52 10.08 9 426093 7152 46252808
Dystonia 38.35 10.08 28 426074 11229 46248731
Intentional product misuse 38.28 10.08 262 425840 46866 46213094
Neck pain 38.06 10.08 322 425780 54984 46204976
Helicobacter infection 37.68 10.08 31 426071 11705 46248255
Haematuria 37.66 10.08 393 425709 26465 46233495
Oxygen consumption increased 37.65 10.08 95 426007 3568 46256392
Stillbirth 37.30 10.08 7 426095 6484 46253476
Gravitational oedema 37.15 10.08 48 426054 1052 46258908
Pelvic pain 36.82 10.08 31 426071 11571 46248389
Tachyarrhythmia 36.52 10.08 109 425993 4523 46255437
Medication error 36.38 10.08 437 425665 30474 46229486
Arthritis 35.91 10.08 493 425609 76823 46183137
Coronary arterial stent insertion 35.84 10.08 80 426022 2773 46257187
Tenosynovitis 35.67 10.08 12 426090 7503 46252457
Jugular vein distension 35.67 10.08 42 426060 834 46259126
Menstruation irregular 35.61 10.08 8 426094 6531 46253429
Immune reconstitution inflammatory syndrome 35.52 10.08 5 426097 5720 46254240
Arteriosclerosis coronary artery 35.36 10.08 158 425944 7998 46251962
International normalised ratio decreased 35.29 10.08 106 425996 4414 46255546
Coagulopathy 35.19 10.08 289 425813 18210 46241750
Death 35.11 10.08 3536 422566 332012 45927948
Burning sensation 35.04 10.08 249 425853 44162 46215798
Upper respiratory tract infection 34.89 10.08 391 425711 63165 46196795
Stomatitis 34.85 10.08 427 425675 67870 46192090
Cardiac arrest 34.60 10.08 1075 425027 89324 46170636
Cerebral haemorrhage 34.23 10.08 403 425699 27968 46231992
Irritability 34.05 10.08 142 425960 28804 46231156
Polyuria 33.96 10.08 143 425959 7052 46252908
Colitis microscopic 33.88 10.08 134 425968 6422 46253538
Depressed level of consciousness 33.70 10.08 616 425486 46953 46213007
Ankylosing spondylitis 33.33 10.08 10 426092 6727 46253233
Dry eye 33.09 10.08 153 425949 30169 46229791
Sinus node dysfunction 32.94 10.08 100 426002 4189 46255771
Poisoning 32.75 10.08 48 426054 13946 46246014
Ill-defined disorder 32.56 10.08 130 425972 26697 46233263
Visual impairment 32.51 10.08 421 425681 66268 46193692
Foot deformity 32.25 10.08 57 426045 15368 46244592
Concomitant disease progression 32.22 10.08 65 426037 2097 46257863
Hepatic function abnormal 31.92 10.08 466 425636 33955 46226005
Metastases to bone 31.86 10.08 70 426032 17406 46242554
Enthesopathy 31.83 10.08 3 426099 4687 46255273
Amenorrhoea 31.79 10.08 21 426081 8874 46251086
Knee arthroplasty 31.78 10.08 110 425992 23555 46236405
Depressed mood 31.33 10.08 177 425925 33142 46226818
Live birth 31.10 10.08 29 426073 10301 46249659
Back pain 30.89 10.08 1584 424518 208455 46051505
Injection site haemorrhage 30.78 10.08 92 426010 20617 46239343
Immunodeficiency 30.63 10.08 45 426057 13061 46246899
Injection site induration 30.36 10.08 18 426084 8061 46251899
Inferior vena cava dilatation 30.27 10.08 13 426089 40 46259920
Pregnancy with contraceptive device 30.25 10.08 3 426099 4500 46255460
Device use error 30.24 10.08 5 426097 5076 46254884
Central nervous system lesion 30.13 10.08 26 426076 9589 46250371
Inflammation 30.08 10.08 292 425810 48489 46211471
Maternal exposure before pregnancy 30.06 10.08 3 426099 4478 46255482
Drug withdrawal syndrome 29.98 10.08 138 425964 27246 46232714
Hypoglycaemic coma 29.92 10.08 70 426032 2504 46257456
Subcutaneous haematoma 29.90 10.08 53 426049 1548 46258412
Bone density decreased 29.80 10.08 27 426075 9725 46250235
Faeces discoloured 29.68 10.08 258 425844 16529 46243431
Serotonin syndrome 29.63 10.08 117 425985 24103 46235857
Blood uric acid increased 29.54 10.08 95 426007 4106 46255854
Acute generalised exanthematous pustulosis 29.33 10.08 166 425936 9239 46250721
Chills 29.31 10.08 660 425442 95372 46164588
Premature labour 29.24 10.08 36 426066 11263 46248697
Pneumonia viral 29.23 10.08 129 425973 6495 46253465
Metabolic acidosis 29.17 10.08 507 425595 38273 46221687
Coronary artery bypass 28.98 10.08 67 426035 2378 46257582
Pruritus 28.90 10.08 1865 424237 240487 46019473
Uveitis 28.78 10.08 22 426080 8619 46251341
Tendonitis 28.74 10.08 54 426048 14223 46245737
Nephrolithiasis 28.73 10.08 180 425922 32871 46227089
Ecchymosis 28.70 10.08 180 425922 10396 46249564
Packed red blood cell transfusion 28.70 10.08 62 426040 2101 46257859
Nodal arrhythmia 28.65 10.08 46 426056 1237 46258723
Alkalosis hypochloraemic 28.57 10.08 18 426084 143 46259817
Hyponatraemic syndrome 28.56 10.08 31 426071 561 46259399
Malignant neoplasm progression 28.38 10.08 419 425683 64507 46195453
Aspartate aminotransferase increased 28.31 10.08 929 425173 77771 46182189
Osteoarthritis 28.26 10.08 397 425705 61628 46198332
Intestinal haemorrhage 28.26 10.08 77 426025 3031 46256929
Caesarean section 28.26 10.08 69 426033 16534 46243426
Rales 28.09 10.08 167 425935 9464 46250496
Nodule 28.05 10.08 63 426039 15542 46244418
Chronic respiratory failure 27.88 10.08 54 426048 1690 46258270
Poor venous access 27.87 10.08 21 426081 8287 46251673
Sinus bradycardia 27.68 10.08 218 425884 13564 46246396
Aortic valve incompetence 27.67 10.08 118 425984 5852 46254108
Prothrombin time shortened 27.56 10.08 54 426048 1705 46258255
Lymphocyte count decreased 27.40 10.08 130 425972 25459 46234501
Neuropathy peripheral 27.37 10.08 626 425476 90267 46169693
Hypervolaemia 27.14 10.08 53 426049 1669 46258291
Bone pain 27.12 10.08 285 425817 46605 46213355
Product storage error 27.06 10.08 41 426061 11751 46248209
Therapeutic response shortened 27.06 10.08 7 426095 5192 46254768
Muscle spasticity 27.01 10.08 39 426063 11401 46248559
Suspected suicide 26.84 10.08 5 426097 4656 46255304
Disease recurrence 26.78 10.08 83 426019 18388 46241572
Angina unstable 26.77 10.08 138 425964 7410 46252550
Hypercapnia 26.75 10.08 98 426004 4528 46255432
Nightmare 26.69 10.08 71 426031 16527 46243433
Retroperitoneal haematoma 26.65 10.08 68 426034 2572 46257388
Dilatation atrial 26.55 10.08 60 426042 2097 46257863
Ejection fraction decreased 26.36 10.08 265 425837 17672 46242288
Neutrophil count decreased 26.33 10.08 261 425841 43165 46216795
Influenza 26.27 10.08 617 425485 88653 46171307
Blood pressure increased 26.23 10.08 919 425183 125747 46134213
Ear pain 26.22 10.08 108 425994 21984 46237976
Oesophageal varices haemorrhage 26.16 10.08 43 426059 1180 46258780
Sedation complication 26.15 10.08 83 426019 3562 46256398
Hypochromic anaemia 26.15 10.08 47 426055 1388 46258572
Malignant melanoma 26.08 10.08 33 426069 10201 46249759
Electrocardiogram ST segment abnormal 25.86 10.08 38 426064 944 46259016
Schizophrenia 25.85 10.08 24 426078 8544 46251416
Nasal congestion 25.82 10.08 598 425504 47515 46212445
Myocardial ischaemia 25.79 10.08 202 425900 12547 46247413
Ear infection 25.78 10.08 115 425987 22898 46237062
Dermatitis exfoliative 25.74 10.08 112 425990 5604 46254356
Disability 25.68 10.08 33 426069 10134 46249826
Tachypnoea 25.60 10.08 221 425881 14130 46245830
Sleep disorder due to general medical condition, insomnia type 25.59 10.08 8 426094 5241 46254719
Cholecystitis chronic 25.58 10.08 35 426067 10464 46249496
Pneumonia aspiration 25.53 10.08 418 425684 31187 46228773
Oxygen therapy 25.53 10.08 54 426048 1803 46258157
Acute coronary syndrome 25.44 10.08 170 425932 10034 46249926
Acidosis 25.40 10.08 182 425920 10992 46248968
Blood pressure fluctuation 25.36 10.08 168 425934 30280 46229680
Crying 25.31 10.08 103 425999 21038 46238922
Haemarthrosis 25.10 10.08 72 426030 2921 46257039
Head injury 25.05 10.08 339 425763 24297 46235663
Scleroderma 25.05 10.08 96 426006 4533 46255427
Nephrotic syndrome 24.96 10.08 100 426002 4821 46255139
Incorrect route of product administration 24.92 10.08 72 426030 16311 46243649
Fear of injection 24.86 10.08 4 426098 4143 46255817
Hypercreatininaemia 24.64 10.08 24 426078 380 46259580
Pre-eclampsia 24.59 10.08 22 426080 7972 46251988
Renal artery stenosis 24.58 10.08 52 426050 1736 46258224
Microcytic anaemia 24.52 10.08 73 426029 3025 46256935
Soft tissue disorder 24.47 10.08 89 426013 4097 46255863
Catheter site infection 24.44 10.08 97 426005 4656 46255304
Renal tubular necrosis 24.32 10.08 175 425927 10584 46249376
Photophobia 24.32 10.08 61 426041 14483 46245477
Galactorrhoea 24.32 10.08 3 426099 3794 46256166
Crohn's disease 24.18 10.08 16 426086 6755 46253205
Paracentesis 24.07 10.08 36 426066 909 46259051
Atrioventricular block first degree 23.99 10.08 116 425986 6070 46253890
Feeling abnormal 23.95 10.08 916 425186 124144 46135816
Cerebral haematoma 23.93 10.08 76 426026 3263 46256697
Dermatitis bullous 23.90 10.08 135 425967 7508 46252452
Unevaluable event 23.89 10.08 571 425531 45604 46214356
Hot flush 23.77 10.08 268 425834 43249 46216711
Blood calcium decreased 23.73 10.08 233 425869 15440 46244520
Abdominal cavity drainage 23.68 10.08 23 426079 363 46259597
Ventricular dysfunction 23.63 10.08 68 426034 2764 46257196
Ocular hyperaemia 23.61 10.08 96 426006 19614 46240346
Lower respiratory tract infection 23.57 10.08 357 425745 54732 46205228
Tooth infection 23.41 10.08 48 426054 12238 46247722
Right atrial dilatation 23.34 10.08 26 426076 485 46259475
Basilar artery occlusion 23.32 10.08 15 426087 124 46259836
Vascular purpura 23.16 10.08 43 426059 1303 46258657
Activated partial thromboplastin time prolonged 23.09 10.08 124 425978 6765 46253195
Fungal infection 23.05 10.08 166 425936 29354 46230606
Mood altered 22.98 10.08 53 426049 12954 46247006
Ischaemic hepatitis 22.96 10.08 55 426047 1998 46257962
Bursitis 22.93 10.08 98 426004 19744 46240216
Hepatotoxicity 22.89 10.08 134 425968 24875 46235085
Adverse reaction 22.87 10.08 24 426078 8066 46251894
Foetal growth restriction 22.81 10.08 16 426086 6551 46253409
White blood cell count decreased 22.61 10.08 817 425285 111414 46148546
Hyperaesthesia 22.55 10.08 23 426079 7833 46252127
Extrasystoles 22.38 10.08 96 426006 4773 46255187
Haematoma muscle 22.15 10.08 28 426074 600 46259360
Brain natriuretic peptide 22.13 10.08 10 426092 36 46259924
Stress 22.08 10.08 334 425768 51217 46208743
Disorientation 22.07 10.08 466 425636 36452 46223508
Decreased appetite 22.04 10.08 2055 424047 191781 46068179
Peripartum cardiomyopathy 22.04 10.08 14 426088 113 46259847
Petechiae 22.02 10.08 194 425908 12476 46247484
Erythema 21.96 10.08 1072 425030 141748 46118212
Aspiration pleural cavity 21.95 10.08 32 426070 789 46259171
Pharyngitis streptococcal 21.89 10.08 27 426075 8441 46251519
Device deployment issue 21.87 10.08 3 426099 3500 46256460
Drug level increased 21.82 10.08 261 425841 18180 46241780
Gouty arthritis 21.80 10.08 25 426077 482 46259478
Complication of device removal 21.77 10.08 3 426099 3487 46256473
Catheter placement 21.71 10.08 52 426050 1889 46258071
Complication of device insertion 21.62 10.08 9 426093 4935 46255025
Cyanosis 21.59 10.08 232 425870 15739 46244221
Cardiac amyloidosis 21.52 10.08 25 426077 489 46259471
Bradyphrenia 21.47 10.08 113 425989 6117 46253843
Hypercalciuria 21.44 10.08 16 426086 172 46259788
Abdominal pain upper 21.31 10.08 1096 425006 144209 46115751
Troponin increased 21.19 10.08 133 425969 7683 46252277
Anger 21.18 10.08 48 426054 11804 46248156
Mydriasis 21.17 10.08 40 426062 10513 46249447
Ureteric rupture 21.15 10.08 7 426095 7 46259953
Emotional disorder 21.15 10.08 51 426051 12273 46247687
Nephrogenic anaemia 21.13 10.08 51 426051 1862 46258098
Hyperhidrosis 21.09 10.08 637 425465 88671 46171289
Hyperglycaemia 21.07 10.08 443 425659 34628 46225332
Occult blood positive 20.95 10.08 76 426026 3494 46256466
Mitral valve stenosis 20.84 10.08 37 426065 1082 46258878
Blood chloride decreased 20.78 10.08 101 426001 5296 46254664
Haemorrhage subcutaneous 20.69 10.08 66 426036 2840 46257120
Hepatojugular reflux 20.68 10.08 7 426095 8 46259952
Grip strength decreased 20.65 10.08 29 426073 8577 46251383
Bundle branch block left 20.65 10.08 114 425988 6285 46253675
Heparin-induced thrombocytopenia 20.62 10.08 86 426016 4223 46255737
Loss of consciousness 20.58 10.08 1196 424906 107042 46152918
Tuberculosis 20.51 10.08 39 426063 10226 46249734
Haemorrhagic disorder 20.51 10.08 30 426072 742 46259218
Eye irritation 20.49 10.08 80 426022 16534 46243426
Abortion induced 20.49 10.08 39 426063 10221 46249739
Anticoagulation drug level above therapeutic 20.41 10.08 39 426063 1208 46258752
Musculoskeletal disorder 20.38 10.08 73 426029 15472 46244488
Disturbance in attention 20.27 10.08 187 425915 31373 46228587
Epilepsy 20.26 10.08 130 425972 23608 46236352
Ventricular arrhythmia 20.22 10.08 73 426029 3348 46256612
Atrial septal defect repair 20.21 10.08 17 426085 220 46259740
Exercise tolerance decreased 20.09 10.08 89 426013 4488 46255472
Pericardial haemorrhage 20.06 10.08 44 426058 1507 46258453
Abdominal pain 20.01 10.08 1817 424285 228214 46031746
Cardiac cirrhosis 20.00 10.08 14 426088 135 46259825
Lung transplant 19.98 10.08 65 426037 2827 46257133
Intervertebral disc protrusion 19.95 10.08 107 425995 20298 46239662
Diabetes mellitus inadequate control 19.79 10.08 196 425906 13018 46246942
Throat tightness 19.75 10.08 109 425993 20530 46239430
Impaired quality of life 19.72 10.08 3 426099 3239 46256721
Walking distance test abnormal 19.72 10.08 24 426078 494 46259466
Transplant dysfunction 19.71 10.08 9 426093 4673 46255287
Haemorrhage intracranial 19.68 10.08 190 425912 12534 46247426
Cholestasis 19.66 10.08 350 425752 26543 46233417
Dry mouth 19.57 10.08 368 425734 54558 46205402
Dyspnoea paroxysmal nocturnal 19.43 10.08 31 426071 829 46259131
Cardiac operation 19.40 10.08 61 426041 2605 46257355
Duodenal ulcer haemorrhage 19.30 10.08 57 426045 2351 46257609
Gastritis erosive 19.29 10.08 98 426004 5232 46254728
Septic shock 19.20 10.08 677 425425 57216 46202744
Limb reduction defect 19.18 10.08 20 426082 345 46259615
Blood parathyroid hormone decreased 19.11 10.08 8 426094 4373 46255587
Generalised tonic-clonic seizure 19.06 10.08 157 425945 26965 46232995
Liver function test increased 18.98 10.08 126 425976 22700 46237260
Catheter site pruritus 18.97 10.08 50 426052 1929 46258031
Sinus arrest 18.96 10.08 46 426056 1685 46258275
Anhedonia 18.88 10.08 160 425942 10175 46249785
Wrong patient received product 18.86 10.08 46 426056 1691 46258269
Surgery 18.73 10.08 170 425932 28615 46231345
Small for dates baby 18.73 10.08 5 426097 3632 46256328
Catheter site erythema 18.67 10.08 79 426023 3904 46256056
Procedural pain 18.56 10.08 60 426042 13119 46246841
Cataract 18.51 10.08 297 425805 45118 46214842
Decubitus ulcer 18.49 10.08 154 425948 9744 46250216
Cardiac hypertrophy 18.48 10.08 34 426068 1023 46258937
Right ventricular dysfunction 18.44 10.08 42 426060 1476 46258484
Metastases to liver 18.43 10.08 104 425998 19481 46240479
Synovial cyst 18.39 10.08 24 426078 7322 46252638
Left ventricular dysfunction 18.33 10.08 158 425944 10097 46249863
Demyelination 18.24 10.08 15 426087 5665 46254295
Product preparation error 18.24 10.08 7 426095 4032 46255928
Haemophagocytic lymphohistiocytosis 18.20 10.08 30 426072 8312 46251648
Pallor 18.20 10.08 305 425797 22861 46237099
Ventricular hypertrophy 18.16 10.08 76 426026 3738 46256222
Skin turgor decreased 18.12 10.08 23 426079 495 46259465
Mental disorder 18.04 10.08 125 425977 22300 46237660
Genital haemorrhage 17.98 10.08 20 426082 6546 46253414
Dysmenorrhoea 17.97 10.08 5 426097 3533 46256427
Glomerulonephritis acute 17.96 10.08 9 426093 43 46259917
Osteonecrosis of jaw 17.96 10.08 214 425888 34188 46225772
Metabolic encephalopathy 17.94 10.08 97 426005 5306 46254654
Catheter site haemorrhage 17.92 10.08 60 426042 2649 46257311
Carpal tunnel syndrome 17.91 10.08 79 426023 15780 46244180
Erythromelalgia 17.87 10.08 13 426089 134 46259826
Skin weeping 17.84 10.08 16 426086 227 46259733
Breast pain 17.82 10.08 26 426076 7568 46252392
Continuous haemodiafiltration 17.82 10.08 33 426069 998 46258962
Blood albumin decreased 17.82 10.08 198 425904 13547 46246413
Blood urea abnormal 17.77 10.08 24 426078 550 46259410
Eosinophilia 17.75 10.08 260 425842 18957 46241003
Pickwickian syndrome 17.75 10.08 18 426084 300 46259660
Paraesthesia oral 17.71 10.08 52 426050 11721 46248239
Swelling 17.71 10.08 942 425160 123569 46136391
Sight disability 17.64 10.08 12 426090 110 46259850
Blood creatinine abnormal 17.60 10.08 55 426047 2341 46257619
Protein total decreased 17.56 10.08 98 426004 5425 46254535
Substance abuse 17.56 10.08 8 426094 4159 46255801
Tracheostomy 17.54 10.08 24 426078 557 46259403
Product substitution issue 17.51 10.08 74 426028 14957 46245003
Femur fracture 17.50 10.08 235 425867 36762 46223198
Cardiac murmur 17.49 10.08 170 425932 11234 46248726
Nephrosclerosis 17.41 10.08 32 426070 962 46258998
Nephropathy 17.40 10.08 91 426011 4914 46255046
Finger deformity 17.38 10.08 13 426089 5149 46254811
Right ventricular enlargement 17.31 10.08 17 426085 272 46259688
Lupus-like syndrome 17.31 10.08 28 426074 7816 46252144
Bone marrow failure 17.29 10.08 180 425922 29489 46230471
Cushingoid 17.26 10.08 19 426083 6247 46253713
Catheterisation cardiac 17.24 10.08 78 426024 3969 46255991
Tetany 17.24 10.08 45 426057 1726 46258234
Hyperprolactinaemia 17.20 10.08 3 426099 2929 46257031
Asterixis 17.16 10.08 36 426066 1195 46258765
Cardiac valve disease 17.14 10.08 77 426025 3907 46256053
Rectosigmoid cancer 17.10 10.08 13 426089 144 46259816
Aortic valve stenosis 17.08 10.08 65 426037 3059 46256901
Blood creatine increased 17.04 10.08 85 426017 4505 46255455
Second primary malignancy 17.02 10.08 21 426081 6563 46253397
Neurotoxicity 16.95 10.08 66 426036 13651 46246309
Myoclonus 16.93 10.08 203 425899 14149 46245811
Deafness neurosensory 16.90 10.08 10 426092 4484 46255476
Neuroleptic malignant syndrome 16.83 10.08 49 426053 11073 46248887
Arteriospasm coronary 16.81 10.08 6 426096 3615 46256345
Volume blood decreased 16.81 10.08 13 426089 148 46259812
Tooth abscess 16.77 10.08 59 426043 12574 46247386
Amnesia 16.72 10.08 273 425829 41358 46218602
Vascular device infection 16.68 10.08 70 426032 3447 46256513
Cleft palate 16.67 10.08 30 426072 887 46259073
Middle insomnia 16.63 10.08 39 426063 9476 46250484
Temperature regulation disorder 16.60 10.08 5 426097 3355 46256605
Platelet count decreased 16.56 10.08 1092 425010 98932 46161028
Mental status changes 16.49 10.08 460 425642 37628 46222332
Rheumatic fever 16.48 10.08 3 426099 2840 46257120
Cardioversion 16.42 10.08 34 426068 1118 46258842
Premature rupture of membranes 16.42 10.08 10 426092 4413 46255547
Cyst 16.41 10.08 56 426046 12044 46247916
Mouth ulceration 16.38 10.08 161 425941 26671 46233289
Urosepsis 16.33 10.08 213 425889 15140 46244820
Vaginal haemorrhage 16.32 10.08 152 425950 25452 46234508
Gastrointestinal angiodysplasia 16.31 10.08 20 426082 415 46259545
Hypoxic-ischaemic encephalopathy 16.25 10.08 77 426025 3996 46255964
Fear 16.22 10.08 222 425880 15950 46244010
Catheter site discharge 16.11 10.08 47 426055 1925 46258035
Pulmonary alveolar haemorrhage 16.11 10.08 78 426024 4084 46255876
Gastric haemorrhage 16.10 10.08 101 426001 5833 46254127
Peripheral sensory neuropathy 16.10 10.08 22 426080 6581 46253379
Lymphadenopathy 16.10 10.08 212 425890 33276 46226684
Haemorrhoidal haemorrhage 16.08 10.08 72 426030 3648 46256312
Menstrual disorder 16.07 10.08 9 426093 4159 46255801
Ulcer 16.02 10.08 93 426009 17299 46242661
Maternal drugs affecting foetus 16.02 10.08 16 426086 5502 46254458
Carbon dioxide increased 15.98 10.08 34 426068 1140 46258820
Drug monitoring procedure not performed 15.95 10.08 19 426083 382 46259578
Irritable bowel syndrome 15.92 10.08 87 426015 16428 46243532
Blood prolactin increased 15.90 10.08 4 426098 3023 46256937
Injection site discolouration 15.88 10.08 24 426078 6886 46253074
Atrial tachycardia 15.88 10.08 49 426053 2071 46257889
Neuralgia 15.85 10.08 122 425980 21261 46238699
Folliculitis 15.81 10.08 20 426082 6183 46253777
Gouty tophus 15.79 10.08 13 426089 163 46259797
Encephalopathy 15.78 10.08 410 425692 33179 46226781
Muscle spasms 15.76 10.08 941 425161 122172 46137788
Weight decreased 15.75 10.08 1684 424418 209165 46050795
Pseudoporphyria 15.73 10.08 13 426089 164 46259796
Venous pressure jugular increased 15.70 10.08 20 426082 432 46259528
Body temperature increased 15.67 10.08 148 425954 24713 46235247
Optic neuritis 15.66 10.08 24 426078 6847 46253113
Hepatorenal syndrome 15.66 10.08 44 426058 1764 46258196
Bundle branch block right 15.65 10.08 86 426016 4733 46255227
Therapeutic embolisation 15.63 10.08 12 426090 135 46259825
Optic ischaemic neuropathy 15.62 10.08 30 426072 933 46259027
Coagulation time prolonged 15.57 10.08 36 426066 1278 46258682
Hypoalbuminaemia 15.55 10.08 151 425951 9976 46249984
Hyperamylasaemia 15.50 10.08 18 426084 352 46259608
Myopathy 15.44 10.08 136 425966 8745 46251215
Subdural haemorrhage 15.44 10.08 60 426042 2852 46257108
Dermatitis allergic 15.34 10.08 61 426041 12542 46247418
Fryns syndrome 15.33 10.08 9 426093 62 46259898
Pulmonary hypoplasia 15.30 10.08 16 426086 277 46259683
Atrial enlargement 15.28 10.08 15 426087 240 46259720
Bleeding varicose vein 15.23 10.08 15 426087 241 46259719
Thermohypoaesthesia 15.23 10.08 11 426091 112 46259848
Catheter site pain 15.22 10.08 72 426030 3734 46256226
Nasal mucosal erosion 15.21 10.08 9 426093 63 46259897
Low cardiac output syndrome 15.21 10.08 16 426086 279 46259681
Dyspnoea at rest 15.17 10.08 69 426033 3519 46256441
Foetal death 15.14 10.08 36 426066 8707 46251253
Renal atrophy 15.14 10.08 35 426067 1242 46258718
Tremor 15.14 10.08 882 425220 114757 46145203
Haematocrit decreased 15.06 10.08 423 425679 34634 46225326
Lacrimation increased 15.05 10.08 84 426018 15777 46244183
Hypocoagulable state 15.04 10.08 31 426071 1016 46258944
Peripheral embolism 15.01 10.08 34 426068 1190 46258770
Scleritis 15.00 10.08 4 426098 2908 46257052
Lethargy 14.95 10.08 590 425512 50581 46209379
Panniculitis 14.95 10.08 18 426084 5686 46254274
Diastolic dysfunction 14.94 10.08 91 426011 5201 46254759
Purging 14.93 10.08 8 426094 45 46259915
Agranulocytosis 14.91 10.08 285 425817 21900 46238060
Anal abscess 14.83 10.08 7 426095 3565 46256395
PO2 abnormal 14.82 10.08 4 426098 0 46259960
Dysgeusia 14.82 10.08 270 425832 40221 46219739
Adverse event 14.80 10.08 221 425881 33963 46225997
Hypokalaemic syndrome 14.79 10.08 8 426094 46 46259914
Gastric disorder 14.76 10.08 164 425938 26541 46233419
Platelet transfusion 14.75 10.08 25 426077 704 46259256
Hepatorenal failure 14.75 10.08 23 426079 603 46259357
Jaundice 14.70 10.08 356 425746 28489 46231471
Electrocardiogram QT shortened 14.68 10.08 11 426091 119 46259841
Cardiac rehabilitation therapy 14.64 10.08 5 426097 6 46259954
Joint effusion 14.64 10.08 58 426044 11937 46248023
Blood glucose decreased 14.57 10.08 248 425854 18644 46241316
Premature baby 14.55 10.08 101 426001 18011 46241949
Haemorrhage 14.51 10.08 626 425476 54243 46205717
Lymphopenia 14.50 10.08 81 426021 15212 46244748
Gastrointestinal toxicity 14.46 10.08 11 426091 4320 46255640
Urine odour abnormal 14.44 10.08 86 426016 4876 46255084
Traumatic haematoma 14.44 10.08 37 426065 1403 46258557
Foot fracture 14.39 10.08 112 425990 19470 46240490
Breast cancer metastatic 14.35 10.08 70 426032 13608 46246352
Gastric varices 14.31 10.08 11 426091 124 46259836
Muscle twitching 14.31 10.08 77 426025 14595 46245365
Liver function test abnormal 14.29 10.08 539 425563 45948 46214012
Circulatory collapse 14.27 10.08 277 425825 21347 46238613
Therapy partial responder 14.26 10.08 13 426089 4669 46255291
Right ventricular dilatation 14.25 10.08 28 426074 886 46259074
Multiple-drug resistance 14.25 10.08 3 426099 2562 46257398
Feeling jittery 14.23 10.08 52 426050 10956 46249004
Diabetic hyperosmolar coma 14.21 10.08 19 426083 431 46259529
Mania 14.17 10.08 51 426051 10795 46249165
Pulmonary vein stenosis 14.13 10.08 9 426093 73 46259887
Mucosal erosion 14.10 10.08 36 426066 1362 46258598
Pulmonary veno-occlusive disease 14.10 10.08 28 426074 893 46259067
Puncture site haemorrhage 14.01 10.08 15 426087 267 46259693
Blood aldosterone increased 13.98 10.08 12 426090 160 46259800
Clostridial sepsis 13.95 10.08 18 426084 394 46259566
Affect lability 13.91 10.08 33 426069 7987 46251973
Joint range of motion decreased 13.86 10.08 81 426021 15043 46244917
Bilirubin conjugated increased 13.82 10.08 55 426047 2643 46257317
Abdominal pain lower 13.82 10.08 125 425977 21056 46238904
Pain in jaw 13.80 10.08 453 425649 37919 46222041
Prothrombin level decreased 13.80 10.08 22 426080 588 46259372
Mitral valve disease 13.76 10.08 48 426054 2164 46257796
Staphylococcus test positive 13.75 10.08 67 426035 3517 46256443
Acute motor-sensory axonal neuropathy 13.71 10.08 17 426085 357 46259603
Extradural haematoma 13.69 10.08 36 426066 1387 46258573
Product adhesion issue 13.67 10.08 15 426087 4940 46255020
Skin graft failure 13.67 10.08 10 426092 104 46259856
Normal newborn 13.64 10.08 21 426081 5980 46253980
Ataxia 13.64 10.08 73 426029 13857 46246103
Frequent bowel movements 13.63 10.08 64 426038 12568 46247392
Drug dependence 13.63 10.08 116 425986 19785 46240175
Pericardial excision 13.62 10.08 6 426096 20 46259940
Spontaneous haematoma 13.61 10.08 24 426078 698 46259262
Gait disturbance 13.57 10.08 1141 424961 144122 46115838
Bundle branch block 13.55 10.08 27 426075 863 46259097
Hypophagia 13.55 10.08 357 425745 28949 46231011
Diabetic metabolic decompensation 13.53 10.08 32 426070 1153 46258807
Ejection fraction abnormal 13.48 10.08 22 426080 600 46259360
Cardiothoracic ratio increased 13.46 10.08 5 426097 9 46259951
Endocarditis 13.41 10.08 85 426017 4927 46255033
Pulmonary arterial pressure abnormal 13.38 10.08 19 426083 457 46259503
Hypothermia 13.37 10.08 170 425932 12013 46247947
Product complaint 13.34 10.08 169 425933 11932 46248028
Limb hypoplasia congenital 13.33 10.08 12 426090 171 46259789
Transplant evaluation 13.32 10.08 30 426072 1046 46258914
Nail disorder 13.29 10.08 33 426069 7863 46252097
Marasmus 13.29 10.08 19 426083 460 46259500
Ventricular extrasystoles 13.28 10.08 157 425945 10906 46249054
Human herpesvirus 6 infection 13.25 10.08 3 426099 2436 46257524
Electrocardiogram repolarisation abnormality 13.20 10.08 33 426069 1232 46258728
Hyperglycaemic hyperosmolar nonketotic syndrome 13.20 10.08 20 426082 511 46259449
Polyneuropathy 13.15 10.08 58 426044 11586 46248374
Hepatic steatosis 13.15 10.08 148 425954 23894 46236066
Rheumatic heart disease 13.13 10.08 5 426097 10 46259950
Blood sodium increased 13.09 10.08 52 426050 2497 46257463
Paranoia 13.08 10.08 51 426051 10546 46249414
Anaphylactic shock 13.08 10.08 120 425982 20154 46239806
Acute cutaneous lupus erythematosus 13.06 10.08 12 426090 176 46259784
International normalised ratio 13.01 10.08 9 426093 85 46259875
Sexual dysfunction 12.96 10.08 3 426099 2400 46257560
Cardiopulmonary failure 12.96 10.08 67 426035 3602 46256358
Heart transplant 12.96 10.08 18 426084 424 46259536
Transcription medication error 12.95 10.08 12 426090 178 46259782
Hypertrophic cardiomyopathy 12.88 10.08 33 426069 1251 46258709
Bipolar disorder 12.88 10.08 29 426073 7148 46252812
Sensitivity to weather change 12.83 10.08 19 426083 5497 46254463
Internal haemorrhage 12.83 10.08 77 426025 4378 46255582
Mucosal dryness 12.81 10.08 48 426054 2242 46257718
Thalamic infarction 12.80 10.08 20 426082 525 46259435
Cystic fibrosis 12.79 10.08 9 426093 3679 46256281
Withdrawal syndrome 12.73 10.08 105 425997 18029 46241931
Myocardial necrosis 12.71 10.08 10 426092 117 46259843
Electrocardiogram ST-T segment depression 12.61 10.08 4 426098 3 46259957
Small intestine gangrene 12.61 10.08 4 426098 3 46259957
Rash pruritic 12.61 10.08 307 425795 43908 46216052
Spinal pain 12.60 10.08 47 426055 9845 46250115
Haemorrhagic diathesis 12.60 10.08 67 426035 3641 46256319
Diabetic nephropathy 12.55 10.08 34 426068 1334 46258626
Embolic stroke 12.54 10.08 66 426036 3573 46256387
Respiratory arrest 12.53 10.08 225 425877 33591 46226369
Ventricular septal defect 12.53 10.08 11 426091 4023 46255937
Rhinorrhoea 12.51 10.08 335 425767 47330 46212630
Congenital nail disorder 12.51 10.08 9 426093 91 46259869
Platelet dysfunction 12.51 10.08 9 426093 91 46259869
Stasis dermatitis 12.50 10.08 22 426080 639 46259321
Hyperaldosteronism 12.49 10.08 14 426088 263 46259697
Food allergy 12.45 10.08 28 426074 6905 46253055
Pulmonary vein occlusion 12.43 10.08 6 426096 26 46259934
Long QT syndrome congenital 12.43 10.08 6 426096 26 46259934
Herpes zoster 12.36 10.08 500 425602 67372 46192588
Antibiotic level above therapeutic 12.34 10.08 13 426089 227 46259733
Brain natriuretic peptide abnormal 12.34 10.08 16 426086 352 46259608
Vaginal infection 12.31 10.08 23 426079 6070 46253890
Shunt occlusion 12.28 10.08 18 426084 446 46259514
Peripheral venous disease 12.27 10.08 72 426030 4060 46255900
Muscle rigidity 12.26 10.08 48 426054 9913 46250047
Prothrombin time abnormal 12.25 10.08 17 426085 400 46259560
Cerebral venous thrombosis 12.25 10.08 45 426057 2082 46257878
Inflammatory bowel disease 12.24 10.08 7 426095 3198 46256762
Respiratory acidosis 12.21 10.08 97 426005 6051 46253909
Ammonia increased 12.19 10.08 75 426027 4302 46255658
Neoplasm progression 12.08 10.08 171 425931 26512 46233448
Arteriosclerosis 12.07 10.08 139 425963 9594 46250366
Blood potassium abnormal 12.07 10.08 44 426058 2028 46257932
Device related infection 12.06 10.08 264 425838 20777 46239183
Cervical dysplasia 12.05 10.08 6 426096 2963 46256997
Vascular graft 12.03 10.08 24 426078 768 46259192
Premature delivery 12.01 10.08 136 425966 21933 46238027
Blood iron abnormal 12 10.08 7 426095 3163 46256797
Urine sodium decreased 11.99 10.08 11 426091 161 46259799
Pharyngeal oedema 11.97 10.08 80 426022 14391 46245569
Transplant rejection 11.96 10.08 46 426056 9550 46250410
Blood pressure inadequately controlled 11.96 10.08 75 426027 4331 46255629
Mechanical ventilation 11.96 10.08 32 426070 1246 46258714
Aortic valve calcification 11.94 10.08 17 426085 410 46259550
Poisoning deliberate 11.93 10.08 35 426067 7891 46252069
Cystitis klebsiella 11.88 10.08 11 426091 163 46259797
Neutropenic sepsis 11.84 10.08 65 426037 12259 46247701
Lymphorrhoea 11.83 10.08 7 426095 49 46259911
Cyanosis central 11.79 10.08 8 426094 73 46259887
Affective disorder 11.78 10.08 16 426086 4799 46255161
Angina pectoris 11.76 10.08 324 425778 26451 46233509
Hypermagnesaemia 11.75 10.08 26 426076 896 46259064
Systemic scleroderma 11.69 10.08 25 426077 841 46259119
Catheter site rash 11.63 10.08 23 426079 731 46259229
Prothrombin consumption time prolonged 11.60 10.08 7 426095 51 46259909
Change of bowel habit 11.55 10.08 39 426063 1729 46258231
Pulmonary artery dilatation 11.55 10.08 12 426090 206 46259754
Peripheral arterial occlusive disease 11.55 10.08 66 426036 3686 46256274
Heart valve incompetence 11.49 10.08 47 426055 2288 46257672
Catheter removal 11.46 10.08 15 426087 333 46259627
Alcohol interaction 11.44 10.08 4 426098 2441 46257519
Staphylococcal sepsis 11.41 10.08 112 425990 7420 46252540
Bone density abnormal 11.41 10.08 7 426095 3077 46256883
Hospitalisation 11.40 10.08 697 425405 62688 46197272
Purpura 11.37 10.08 140 425962 9818 46250142
Urine chloride decreased 11.36 10.08 8 426094 78 46259882
Arteriovenous malformation 11.35 10.08 31 426071 1222 46258738
Febrile bone marrow aplasia 11.30 10.08 29 426073 6833 46253127
Aggression 11.29 10.08 143 425959 22601 46237359
Polyarthritis 11.28 10.08 27 426075 6515 46253445
Pathogen resistance 11.27 10.08 24 426078 6036 46253924
Hepatitis fulminant 11.24 10.08 61 426041 3341 46256619
Anal fistula 11.24 10.08 5 426097 2636 46257324
Fracture delayed union 11.24 10.08 3 426099 2179 46257781
Angiopathy 11.22 10.08 72 426030 4191 46255769
End stage renal disease 11.22 10.08 92 426010 5794 46254166
Infection susceptibility increased 11.21 10.08 3 426099 2176 46257784
Base excess negative 11.21 10.08 4 426098 6 46259954
Retroperitoneal haemorrhage 11.17 10.08 52 426050 2678 46257282
Mouth breathing 11.16 10.08 6 426096 34 46259926
Lymphoedema 11.13 10.08 124 425978 8488 46251472
Rectosigmoid cancer metastatic 11.12 10.08 3 426099 0 46259960
Mitral valve disease mixed 11.12 10.08 3 426099 0 46259960
Ammonia decreased 11.12 10.08 3 426099 0 46259960
Thyroid gland scan abnormal 11.12 10.08 3 426099 0 46259960
Oedema due to renal disease 11.12 10.08 3 426099 0 46259960
Tracheal operation 11.12 10.08 3 426099 0 46259960
Urine chloride increased 11.12 10.08 3 426099 0 46259960
Benign small intestinal neoplasm 11.12 10.08 3 426099 0 46259960
Intestinal pseudo-obstruction 11.09 10.08 21 426081 646 46259314
Disseminated intravascular coagulation 11.07 10.08 239 425863 18766 46241194
Carbon dioxide abnormal 11.03 10.08 10 426092 144 46259816
Cytomegalovirus infection 11.02 10.08 109 425993 18035 46241925
Pulmonary hypertensive crisis 10.96 10.08 11 426091 181 46259779
Peritoneal dialysis 10.93 10.08 15 426087 349 46259611
Cardiac valve replacement complication 10.91 10.08 11 426091 182 46259778
Feeling hot 10.91 10.08 263 425839 37665 46222295
Cardiorenal syndrome 10.91 10.08 20 426082 600 46259360
Pleural thickening 10.91 10.08 5 426097 2590 46257370
Alkalosis 10.90 10.08 14 426088 305 46259655
Hypoprothrombinaemia 10.86 10.08 14 426088 306 46259654
Blood culture negative 10.86 10.08 10 426092 147 46259813
Tuberculin test positive 10.86 10.08 7 426095 2997 46256963
Cardiac resynchronisation therapy 10.86 10.08 5 426097 19 46259941
Brain compression 10.84 10.08 15 426087 352 46259608
Cystitis 10.80 10.08 298 425804 41943 46218017
Ulcer haemorrhage 10.76 10.08 61 426041 3397 46256563
Small intestinal obstruction 10.74 10.08 95 426007 16077 46243883
Intraocular pressure increased 10.74 10.08 24 426078 5933 46254027
Lip erosion 10.71 10.08 23 426079 776 46259184
Injection site nodule 10.71 10.08 9 426093 3362 46256598
Mobility decreased 10.69 10.08 448 425654 60146 46199814
Varicella zoster virus infection 10.68 10.08 4 426098 2339 46257621
Leukaemic infiltration renal 10.66 10.08 5 426097 20 46259940
Postpericardiotomy syndrome 10.66 10.08 5 426097 20 46259940
Haemorrhagic transformation stroke 10.65 10.08 29 426073 1141 46258819
Adrenal insufficiency 10.63 10.08 73 426029 13051 46246909
Viral infection 10.63 10.08 203 425899 30032 46229928
Congenital oral malformation 10.63 10.08 11 426091 188 46259772
Blood pressure systolic decreased 10.61 10.08 84 426018 5234 46254726
Endometriosis 10.61 10.08 12 426090 3898 46256062
Craniocerebral injury 10.60 10.08 44 426058 2156 46257804
Rectal ulcer haemorrhage 10.58 10.08 11 426091 189 46259771
Amyloidosis 10.58 10.08 28 426074 1083 46258877
Joint laxity 10.57 10.08 3 426099 2093 46257867
Incorrect dose administered by device 10.56 10.08 7 426095 2953 46257007
Hepatic cancer 10.55 10.08 56 426046 3041 46256919
Biopsy liver 10.52 10.08 16 426086 410 46259550
Infective exacerbation of chronic obstructive airways disease 10.50 10.08 29 426073 1151 46258809
Product physical issue 10.49 10.08 18 426084 4909 46255051
Pulmonary haemorrhage 10.49 10.08 98 426004 6407 46253553
Patent ductus arteriosus repair 10.48 10.08 5 426097 21 46259939
Large intestinal polypectomy 10.45 10.08 11 426091 192 46259768
Fine motor skill dysfunction 10.43 10.08 11 426091 3689 46256271
Vitamin B1 decreased 10.38 10.08 6 426096 40 46259920
Ammonia abnormal 10.35 10.08 8 426094 91 46259869
Electrocardiogram U wave present 10.35 10.08 8 426094 91 46259869
Infected skin ulcer 10.33 10.08 44 426058 2181 46257779
Wound infection pseudomonas 10.32 10.08 33 426069 1422 46258538
Mucormycosis 10.30 10.08 4 426098 2288 46257672
Aortic valve replacement 10.30 10.08 21 426081 683 46259277
Post transplant lymphoproliferative disorder 10.28 10.08 12 426090 3844 46256116
Congenital diaphragmatic hernia 10.27 10.08 11 426091 196 46259764
Pancreatic steatosis 10.26 10.08 26 426076 979 46258981
Acute graft versus host disease 10.26 10.08 13 426089 4017 46255943
Injury associated with device 10.26 10.08 7 426095 2908 46257052
Hyperthyroidism 10.25 10.08 157 425945 11554 46248406
Deformity 10.25 10.08 33 426069 7224 46252736
Balance disorder 10.24 10.08 702 425400 63819 46196141
Bone cyst 10.23 10.08 3 426099 2048 46257912
Psychomotor hyperactivity 10.20 10.08 49 426053 9564 46250396
Heparin-induced thrombocytopenia test 10.19 10.08 4 426098 9 46259951
Troponin 10.19 10.08 4 426098 9 46259951
Aplastic anaemia 10.18 10.08 105 425997 7048 46252912
Epstein-Barr virus infection 10.18 10.08 30 426072 6754 46253206
Central venous catheterisation 10.10 10.08 41 426061 1989 46257971

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure congestive 1728.72 11.26 3241 328865 81166 29539206
Acute kidney injury 1549.52 11.26 6561 325545 267281 29353091
Cardiac failure 1255.17 11.26 2821 329285 80597 29539775
Hyperkalaemia 837.67 11.26 2090 330016 63920 29556452
Drug ineffective 724.85 11.26 1700 330406 338687 29281685
Oedema peripheral 506 11.26 2418 329688 103414 29516958
Drug abuse 477.97 11.26 157 331949 81915 29538457
Completed suicide 452.76 11.26 271 331835 99221 29521151
Renal failure 430.79 11.26 2672 329434 126294 29494078
International normalised ratio increased 403.72 11.26 1306 330800 46433 29573939
Hypotension 365.23 11.26 3609 328497 196956 29423416
Toxicity to various agents 355.16 11.26 911 331195 176272 29444100
Dyspnoea 333.59 11.26 5362 326744 327933 29292439
Off label use 327.92 11.26 1536 330570 247754 29372618
Oedema 288.75 11.26 1090 331016 41903 29578469
Fluid retention 280.09 11.26 756 331350 24242 29596130
Blood creatinine increased 266.75 11.26 1831 330275 89544 29530828
Blood urea increased 248.65 11.26 840 331266 30541 29589831
Atrial fibrillation 246.50 11.26 2044 330062 106080 29514292
Renal impairment 245.74 11.26 1687 330419 82497 29537875
Cardiac failure chronic 230.02 11.26 304 331802 5559 29614813
Hypokalaemia 225.24 11.26 1127 330979 49065 29571307
Ascites 216.26 11.26 880 331226 35041 29585331
Pulmonary hypertension 208.53 11.26 571 331535 18465 29601907
Rheumatoid arthritis 208.13 11.26 98 332008 41099 29579273
Headache 205.14 11.26 1184 330922 181122 29439250
Hepatic encephalopathy 203.98 11.26 472 331634 13720 29606652
Chronic kidney disease 175.68 11.26 858 331248 36980 29583392
Intentional overdose 173.56 11.26 124 331982 41357 29579015
Suicide attempt 170.95 11.26 97 332009 36600 29583772
Hyponatraemia 169.13 11.26 1300 330806 65902 29554470
Suicidal ideation 168.89 11.26 95 332011 36019 29584353
Anaemia 168.70 11.26 3239 328867 204753 29415619
Melaena 164.04 11.26 754 331352 31683 29588689
Bradycardia 162.36 11.26 1263 330843 64263 29556109
Foetal exposure during pregnancy 161.23 11.26 105 332001 36766 29583606
Dehydration 152.75 11.26 2064 330042 121475 29498897
Arthralgia 146.18 11.26 894 331212 134897 29485475
Treatment failure 145.96 11.26 103 332003 34576 29585796
Ventricular tachycardia 144.71 11.26 586 331520 23276 29597096
Product use in unapproved indication 141.91 11.26 386 331720 73307 29547065
Gastrointestinal haemorrhage 139.52 11.26 1477 330629 81969 29538403
Pleural effusion 138.22 11.26 1341 330765 72725 29547647
Injection site pain 135.70 11.26 84 332022 30226 29590146
Febrile neutropenia 134.19 11.26 667 331439 106026 29514346
Pulmonary oedema 134.00 11.26 891 331215 43084 29577288
Fall 130.31 11.26 2781 329325 179091 29441281
Hypoglycaemia 125.88 11.26 982 331124 49999 29570373
Intentional product misuse 124.79 11.26 120 331986 34547 29585825
Pyrexia 124.72 11.26 2409 329697 292080 29328292
Lactic acidosis 122.17 11.26 675 331431 30538 29589834
Syncope 120.30 11.26 1455 330651 83448 29536924
Drug dependence 119.94 11.26 43 332063 21252 29599120
Neutropenia 115.18 11.26 893 331213 127647 29492725
Therapeutic product effect incomplete 115.08 11.26 123 331983 33711 29586661
Right ventricular failure 114.08 11.26 266 331840 7770 29612602
Orthostatic hypotension 104.38 11.26 534 331572 23445 29596927
Cardiac failure acute 103.60 11.26 279 331827 8930 29611442
Drug hypersensitivity 101.41 11.26 403 331703 68116 29552256
Generalised oedema 101.12 11.26 326 331780 11559 29608813
Myocardial infarction 100.45 11.26 1953 330153 123672 29496700
Seizure 100.41 11.26 659 331447 97816 29522556
Orthopnoea 98.45 11.26 179 331927 4361 29616011
Fluid overload 98.13 11.26 446 331660 18646 29601726
Depression 96.92 11.26 596 331510 89841 29530531
Hypovolaemia 96.10 11.26 260 331846 8345 29612027
Pulmonary arterial hypertension 95.94 11.26 273 331833 9028 29611344
Chronic obstructive pulmonary disease 94.95 11.26 853 331253 45273 29575099
Blood potassium increased 94.22 11.26 393 331713 15820 29604552
Dyspnoea exertional 91.64 11.26 690 331416 34740 29585632
Aggression 90.85 11.26 169 331937 36738 29583634
Rectal haemorrhage 90.69 11.26 681 331425 34258 29586114
Cardiogenic shock 89.75 11.26 398 331708 16463 29603909
Intentional product use issue 88.69 11.26 168 331938 36272 29584100
Psychotic disorder 87.79 11.26 66 332040 21449 29598923
Insomnia 87.07 11.26 641 331465 92695 29527677
Shock haemorrhagic 87.03 11.26 274 331832 9591 29610781
Nausea 86.62 11.26 2570 329536 294387 29325985
Drug interaction 81.36 11.26 2837 329269 196731 29423641
Urticaria 80.89 11.26 321 331785 54285 29566087
Rash 80.62 11.26 1571 330535 190318 29430054
Drug withdrawal syndrome 80.53 11.26 61 332045 19748 29600624
Ejection fraction decreased 79.86 11.26 357 331749 14818 29605554
Coronary artery disease 79.80 11.26 873 331233 48839 29571533
Product dose omission issue 79.04 11.26 643 331463 90988 29529384
Overdose 78.75 11.26 579 331527 83758 29536614
Brain natriuretic peptide increased 78.66 11.26 152 331954 3883 29616489
Therapeutic product effect decreased 77.14 11.26 127 331979 28949 29591423
Immune reconstitution inflammatory syndrome 75.25 11.26 7 332099 9094 29611278
Metabolic alkalosis 72.03 11.26 81 332025 1243 29619129
Mitral valve incompetence 71.66 11.26 314 331792 12920 29607452
Sinusitis 70.86 11.26 166 331940 33179 29587193
Mucosal inflammation 70.40 11.26 145 331961 30349 29590023
Respiratory failure 70.31 11.26 1534 330572 99108 29521264
Acute pulmonary oedema 70.26 11.26 213 331893 7302 29613070
Infusion related reaction 69.70 11.26 224 331882 40340 29580032
Nasopharyngitis 69.36 11.26 376 331730 58473 29561899
Gravitational oedema 69.14 11.26 56 332050 554 29619818
Psoriasis 68.74 11.26 241 331865 42265 29578107
Tricuspid valve incompetence 67.53 11.26 230 331876 8393 29611979
Psoriatic arthropathy 67.38 11.26 46 332060 15715 29604657
Infective pulmonary exacerbation of cystic fibrosis 67.26 11.26 8 332098 8564 29611808
Hepatic failure 67.23 11.26 624 331482 33419 29586953
Exposure during pregnancy 67.13 11.26 11 332095 9250 29611122
Renal injury 66.35 11.26 282 331824 11447 29608925
Gout 66.10 11.26 372 331734 16943 29603429
Drug intolerance 65.96 11.26 268 331838 45023 29575349
Venous pressure jugular increased 65.64 11.26 58 332048 653 29619719
Hypersensitivity 64.33 11.26 344 331762 53684 29566688
Colitis ulcerative 63.23 11.26 41 332065 14393 29605979
Ischaemic cardiomyopathy 63.17 11.26 183 331923 6114 29614258
Left ventricular failure 62.07 11.26 157 331949 4834 29615538
Pain 61.81 11.26 1450 330656 171191 29449181
Hypernatraemia 61.61 11.26 203 331903 7281 29613091
Asthma 61.28 11.26 201 331905 35973 29584399
Musculoskeletal stiffness 61.04 11.26 199 331907 35682 29584690
Anuria 60.67 11.26 251 331855 10065 29610307
Urine output decreased 60.63 11.26 241 331865 9488 29610884
Fatigue 60.54 11.26 2923 329183 317750 29302622
Colitis 60.36 11.26 160 331946 30660 29589712
N-terminal prohormone brain natriuretic peptide increased 59.41 11.26 74 332032 1272 29619100
Multiple sclerosis relapse 59.37 11.26 23 332083 10839 29609533
Poisoning 59.14 11.26 26 332080 11356 29609016
Coronary artery bypass 58.68 11.26 157 331949 5005 29615367
Irritability 57.21 11.26 105 332001 22945 29597427
Acute myocardial infarction 57.11 11.26 864 331242 52075 29568297
Product use issue 55.89 11.26 291 331815 45725 29574647
Rhabdomyolysis 55.76 11.26 1003 331103 62577 29557795
Synovitis 54.67 11.26 20 332086 9763 29610609
Intentional self-injury 54.58 11.26 42 332064 13490 29606882
Accidental exposure to product 54.33 11.26 22 332084 10093 29610279
Cardiomegaly 54.25 11.26 310 331796 14199 29606173
Abnormal behaviour 54.08 11.26 128 331978 25495 29594877
Hepatic cirrhosis 53.52 11.26 332 331774 15667 29604705
Schizophrenia 53.16 11.26 17 332089 9031 29611341
Pemphigoid 53.10 11.26 194 331912 7334 29613038
Left ventricular dysfunction 52.33 11.26 213 331893 8478 29611894
Anaphylactic reaction 52.01 11.26 149 331957 27833 29592539
Injection site erythema 52.01 11.26 46 332060 13788 29606584
Sedation 51.89 11.26 63 332043 16310 29604062
Injury 50.54 11.26 413 331693 21318 29599054
Serotonin syndrome 50.45 11.26 75 332031 17816 29602556
Concomitant disease progression 50.44 11.26 96 332010 2424 29617948
Haematoma 49.80 11.26 444 331662 23509 29596863
Jugular vein distension 49.75 11.26 44 332062 496 29619876
Cytomegalovirus infection 49.38 11.26 119 331987 23555 29596817
Asthenia 49.19 11.26 2959 329147 218331 29402041
Stomatitis 47.98 11.26 231 331875 37048 29583324
Injection site reaction 47.90 11.26 30 332076 10730 29609642
Peripheral swelling 47.88 11.26 947 331159 60127 29560245
Substance abuse 47.52 11.26 10 332096 7030 29613342
Vomiting 47.24 11.26 1975 330131 217843 29402529
Erectile dysfunction 47.15 11.26 80 332026 18022 29602350
Infection 46.57 11.26 598 331508 77476 29542896
Fear 46.35 11.26 240 331866 10585 29609787
Rales 46.27 11.26 168 331938 6332 29614040
Cardiomyopathy 46.20 11.26 307 331799 14836 29605536
Aortic stenosis 45.89 11.26 123 331983 3925 29616447
Pathogen resistance 45.65 11.26 18 332088 8392 29611980
Joint swelling 45.39 11.26 319 331787 46627 29573745
Torsade de pointes 44.71 11.26 178 331928 7012 29613360
Neuropathy peripheral 43.83 11.26 535 331571 69940 29550432
Presyncope 43.38 11.26 316 331790 15740 29604632
Haematotoxicity 43.25 11.26 8 332098 6162 29614210
Blood pressure decreased 43.18 11.26 748 331358 46327 29574045
Oliguria 42.96 11.26 180 331926 7259 29613113
Akathisia 42.82 11.26 7 332099 5897 29614475
Multiple organ dysfunction syndrome 42.81 11.26 963 331143 62524 29557848
Loss of personal independence in daily activities 42.78 11.26 111 331995 21424 29598948
Agitation 42.77 11.26 388 331718 53685 29566687
Cardioactive drug level increased 42.58 11.26 70 332036 1569 29618803
Back pain 42.37 11.26 842 331264 101754 29518618
Atrioventricular block 41.90 11.26 176 331930 7106 29613266
Migraine 41.37 11.26 49 332057 12825 29607547
Myocardial ischaemia 41.29 11.26 331 331775 16986 29603386
Poisoning deliberate 40.65 11.26 8 332098 5896 29614476
Drug resistance 40.58 11.26 103 332003 20030 29600342
Anhedonia 40.42 11.26 192 331914 8177 29612195
Tremor 40.36 11.26 590 331516 74773 29545599
Panic attack 40.34 11.26 23 332083 8658 29611714
Paraesthesia 40.33 11.26 396 331710 53931 29566441
Hypoaesthesia 39.96 11.26 396 331710 53834 29566538
Diastolic dysfunction 39.87 11.26 121 331985 4150 29616222
Hypoglycaemic coma 39.69 11.26 83 332023 2248 29618124
Dyskinesia 39.32 11.26 118 331988 21716 29598656
Acute respiratory failure 39.20 11.26 449 331657 25401 29594971
Anxiety 38.80 11.26 732 331374 89139 29531233
Congestive cardiomyopathy 38.78 11.26 161 331945 6466 29613906
Upper gastrointestinal haemorrhage 38.68 11.26 394 331712 21634 29598738
Generalised tonic-clonic seizure 38.66 11.26 101 332005 19450 29600922
Polyuria 38.53 11.26 172 331934 7134 29613238
Haematuria 38.49 11.26 705 331401 44129 29576243
Malignant neoplasm progression 38.33 11.26 567 331539 71720 29548652
Azotaemia 37.83 11.26 131 331975 4821 29615551
Arthropathy 37.33 11.26 112 331994 20615 29599757
Haemoglobin decreased 37.12 11.26 1583 330523 112515 29507857
Inappropriate schedule of product administration 36.93 11.26 273 331833 39455 29580917
Lymphadenopathy 36.27 11.26 143 331963 24233 29596139
Nephrolithiasis 35.99 11.26 147 331959 24663 29595709
Depressed mood 35.99 11.26 85 332021 16944 29603428
Withdrawal syndrome 35.95 11.26 43 332063 11207 29609165
Iron deficiency anaemia 35.86 11.26 196 331910 8828 29611544
Neutrophil count decreased 35.62 11.26 300 331806 42154 29578218
Drug ineffective for unapproved indication 35.40 11.26 41 332065 10839 29609533
Hepatic cancer 35.17 11.26 155 331951 6393 29613979
Acrodermatitis enteropathica 35.13 11.26 10 332096 0 29620372
Bundle branch block left 34.94 11.26 132 331974 5072 29615300
Blood pressure fluctuation 34.93 11.26 90 332016 17413 29602959
Gastrointestinal disorder 34.68 11.26 177 331929 27960 29592412
Vascular purpura 34.67 11.26 63 332043 1534 29618838
Uveitis 34.55 11.26 9 332097 5468 29614904
Cardiac disorder 34.49 11.26 628 331478 39265 29581107
Arrhythmia 34.09 11.26 537 331569 32632 29587740
Hallucination, auditory 33.94 11.26 35 332071 9754 29610618
Influenza like illness 33.92 11.26 157 331949 25448 29594924
Ventricular fibrillation 33.76 11.26 285 331821 14853 29605519
Alcohol abuse 33.38 11.26 9 332097 5344 29615028
Left ventricular dilatation 33.25 11.26 38 332068 594 29619778
Device issue 33.16 11.26 23 332083 7793 29612579
Vision blurred 33.09 11.26 300 331806 41516 29578856
Sopor 33.03 11.26 222 331884 10769 29609603
Chills 32.84 11.26 584 331522 71754 29548618
Diabetic ketoacidosis 32.83 11.26 81 332025 15905 29604467
Dialysis 32.38 11.26 221 331885 10775 29609597
Dystonia 32.36 11.26 36 332070 9691 29610681
Sexual dysfunction 32.32 11.26 13 332093 5988 29614384
Dyspnoea paroxysmal nocturnal 31.96 11.26 51 332055 1114 29619258
Hypocoagulable state 31.95 11.26 45 332061 876 29619496
Anger 31.95 11.26 46 332060 11074 29609298
Oesophageal varices haemorrhage 31.90 11.26 90 332016 2961 29617411
Subdural haematoma 31.73 11.26 336 331770 18636 29601736
Hyperuricaemia 31.70 11.26 164 331942 7230 29613142
Ankylosing spondylitis 31.52 11.26 6 332100 4528 29615844
Memory impairment 31.50 11.26 262 331844 36912 29583460
Pancreatitis 31.45 11.26 256 331850 36234 29584138
Erythema 31.25 11.26 638 331468 76813 29543559
Blood loss anaemia 31.21 11.26 167 331939 7460 29612912
White blood cell count decreased 31.12 11.26 701 331405 83246 29537126
Acute graft versus host disease 31.10 11.26 13 332093 5851 29614521
Product storage error 31.06 11.26 16 332090 6375 29613997
Injection site swelling 30.88 11.26 31 332075 8749 29611623
Vitamin B1 deficiency 30.86 11.26 23 332083 199 29620173
Cardiac output decreased 30.84 11.26 43 332063 829 29619543
Blood potassium decreased 30.69 11.26 301 331805 16361 29604011
Cardiorenal syndrome 30.40 11.26 40 332066 728 29619644
Mania 30.32 11.26 34 332072 9120 29611252
Nightmare 29.97 11.26 55 332051 12021 29608351
Wrong technique in product usage process 29.96 11.26 212 331894 30943 29589429
Osteonecrosis of jaw 29.80 11.26 106 332000 18512 29601860
Cor pulmonale 29.79 11.26 39 332067 706 29619666
Epistaxis 29.79 11.26 784 331322 52197 29568175
Injection site haemorrhage 29.67 11.26 26 332080 7829 29612543
International normalised ratio decreased 29.65 11.26 115 331991 4475 29615897
Cardiac murmur 29.59 11.26 152 331954 6682 29613690
Normochromic normocytic anaemia 29.44 11.26 104 332002 3866 29616506
Haemodialysis 29.38 11.26 217 331889 10856 29609516
Sleep disorder 29.04 11.26 156 331950 24323 29596049
Tuberculosis 29.01 11.26 28 332078 8049 29612323
Diplopia 28.90 11.26 69 332037 13703 29606669
Multiple sclerosis 28.75 11.26 23 332083 7244 29613128
Lipodystrophy acquired 28.74 11.26 3 332103 3557 29616815
Prothrombin time prolonged 28.61 11.26 189 331917 9114 29611258
Blood creatine increased 28.41 11.26 111 331995 4334 29616038
Atrioventricular block complete 28.40 11.26 176 331930 8301 29612071
Alcohol poisoning 28.36 11.26 4 332102 3760 29616612
Transfusion 28.28 11.26 160 331946 7301 29613071
Diverticulitis 27.47 11.26 100 332006 17345 29603027
Muscle spasms 27.39 11.26 530 331576 64308 29556064
Blood lactic acid 27.37 11.26 27 332079 353 29620019
Neuroleptic malignant syndrome 27.28 11.26 91 332015 16204 29604168
Concomitant disease aggravated 27.24 11.26 121 331985 5008 29615364
Progressive multifocal leukoencephalopathy 27.18 11.26 36 332070 8977 29611395
Euphoric mood 27.16 11.26 7 332099 4283 29616089
Hypoxia 27.15 11.26 709 331397 47145 29573227
Blood pressure increased 27.12 11.26 599 331507 71329 29549043
Nephrotic syndrome 26.99 11.26 149 331957 6736 29613636
Mental disorder 26.96 11.26 69 332037 13380 29606992
Herpes zoster 26.76 11.26 208 331898 29735 29590637
Product quality issue 26.76 11.26 112 331994 18662 29601710
Amnesia 26.69 11.26 159 331947 24162 29596210
Dysphagia 26.61 11.26 455 331651 56243 29564129
Leukopenia 26.57 11.26 450 331656 55709 29564663
Neutropenic sepsis 26.54 11.26 54 332052 11355 29609017
Atrial flutter 26.31 11.26 258 331848 14023 29606349
Nephrogenic anaemia 26.30 11.26 67 332039 2072 29618300
Myalgia 26.25 11.26 648 331458 76019 29544353
Hepatorenal syndrome 26.18 11.26 74 332032 2437 29617935
Neurotoxicity 26.14 11.26 68 332038 13114 29607258
Haematemesis 26.09 11.26 422 331684 25781 29594591
Premature baby 26.07 11.26 96 332010 16595 29603777
Basal cell carcinoma 26.04 11.26 91 332015 15977 29604395
No adverse event 26.03 11.26 102 332004 17317 29603055
Arthritis 26.00 11.26 161 331945 24240 29596132
Abdominal pain 25.96 11.26 1234 330872 134420 29485952
Mucormycosis 25.88 11.26 13 332093 5255 29615117
Paranoia 25.64 11.26 46 332060 10142 29610230
Prostate cancer 25.57 11.26 158 331948 23799 29596573
Disturbance in attention 25.17 11.26 143 331963 21986 29598386
Sudden cardiac death 25.05 11.26 95 332011 3657 29616715
Pseudoporphyria 25.02 11.26 22 332084 246 29620126
Polyomavirus-associated nephropathy 24.92 11.26 3 332103 3182 29617190
Respiratory arrest 24.88 11.26 206 331900 29052 29591320
Appendicitis 24.87 11.26 19 332087 6125 29614247
Tinnitus 24.82 11.26 93 332013 15995 29604377
Cardiac arrest 24.76 11.26 1263 330843 91587 29528785
Post transplant lymphoproliferative disorder 24.74 11.26 14 332092 5292 29615080
Hyperhidrosis 24.64 11.26 561 331545 66529 29553843
Injection site bruising 24.58 11.26 27 332079 7311 29613061
Influenza 24.55 11.26 336 331770 43062 29577310
Night sweats 24.41 11.26 81 332025 14447 29605925
Priapism 24.38 11.26 11 332095 4732 29615640
Cognitive disorder 24.37 11.26 158 331948 23532 29596840
Glomerular filtration rate decreased 24.33 11.26 212 331894 11150 29609222
Somnolence 24.33 11.26 853 331253 95910 29524462
Cardiac amyloidosis 24.27 11.26 36 332070 736 29619636
Neoplasm progression 24.18 11.26 110 331996 17913 29602459
Salivary hypersecretion 24.09 11.26 29 332077 7537 29612835
Acute graft versus host disease in skin 23.97 11.26 10 332096 4506 29615866
Pericardial haemorrhage 23.88 11.26 79 332027 2839 29617533
Congestive hepatopathy 23.79 11.26 60 332046 1844 29618528
Left ventricular enlargement 23.77 11.26 31 332075 559 29619813
Eyelid ptosis 23.74 11.26 14 332092 5174 29615198
Alopecia 23.33 11.26 122 331984 19153 29601219
Blood pressure systolic decreased 23.23 11.26 92 332014 3615 29616757
Musculoskeletal pain 23.17 11.26 225 331881 30715 29589657
Apathy 23.09 11.26 21 332085 6211 29614161
Emotional distress 23.08 11.26 272 331834 15493 29604879
Hepatotoxicity 23.02 11.26 113 331993 18032 29602340
Drug screen positive 23.00 11.26 10 332096 4397 29615975
Ventricular extrasystoles 22.98 11.26 211 331895 11263 29609109
Device interaction 22.97 11.26 26 332080 402 29619970
Mood altered 22.85 11.26 35 332071 8215 29612157
Anal abscess 22.75 11.26 14 332092 5055 29615317
Ventricular failure 22.67 11.26 15 332091 105 29620267
Renal ischaemia 22.53 11.26 29 332077 516 29619856
Crohn's disease 22.52 11.26 10 332096 4342 29616030
Suspected suicide 22.37 11.26 4 332102 3157 29617215
Nephrocalcinosis 22.13 11.26 27 332079 454 29619918
Abdominal discomfort 22.10 11.26 394 331712 48397 29571975
Peripheral venous disease 21.99 11.26 61 332045 1987 29618385
On and off phenomenon 21.95 11.26 3 332103 2888 29617484
Neuromyopathy 21.94 11.26 39 332067 933 29619439
Oropharyngeal pain 21.86 11.26 206 331900 28290 29592082
Maternal drugs affecting foetus 21.82 11.26 10 332096 4263 29616109
Bradyarrhythmia 21.81 11.26 59 332047 1893 29618479
Tenosynovitis 21.75 11.26 6 332100 3509 29616863
Hypercapnia 21.67 11.26 92 332014 3732 29616640
Dilatation atrial 21.66 11.26 62 332044 2057 29618315
Cardiac valve disease 21.65 11.26 77 332029 2872 29617500
Vascular graft 21.57 11.26 49 332057 1406 29618966
Coma hepatic 21.54 11.26 26 332080 432 29619940
Incorrect dose administered 21.45 11.26 236 331870 31450 29588922
Chronic hepatic failure 21.38 11.26 27 332079 471 29619901
Eosinophilia 21.36 11.26 355 331751 21805 29598567
Osteonecrosis 21.33 11.26 99 332007 16036 29604336
Tardive dyskinesia 21.30 11.26 15 332091 5042 29615330
Pericardial effusion 21.22 11.26 341 331765 20803 29599569
Graft versus host disease 21.18 11.26 51 332055 10099 29610273
Tachycardia 21.16 11.26 639 331467 73100 29547272
Lower gastrointestinal haemorrhage 21.03 11.26 155 331951 7749 29612623
Epilepsy 21.01 11.26 134 331972 20035 29600337
Pneumocystis jirovecii pneumonia 20.93 11.26 108 331998 17012 29603360
Aspergillus infection 20.78 11.26 52 332054 10162 29610210
Unevaluable event 20.75 11.26 480 331626 31305 29589067
Therapeutic response shortened 20.73 11.26 7 332099 3593 29616779
Hyponatraemic syndrome 20.67 11.26 19 332087 226 29620146
Mental impairment 20.66 11.26 45 332061 9232 29611140
Extrapyramidal disorder 20.56 11.26 56 332050 10637 29609735
Therapeutic response decreased 20.45 11.26 172 331934 24177 29596195
Muscle twitching 20.36 11.26 37 332069 8118 29612254
Apparent death 20.20 11.26 7 332099 3535 29616837
Respiratory depression 20.11 11.26 63 332043 11440 29608932
Diffuse large B-cell lymphoma 20.10 11.26 35 332071 7806 29612566
Hydrothorax 20.06 11.26 26 332080 466 29619906
Epstein-Barr virus infection 20.01 11.26 27 332079 6679 29613693
Atrial tachycardia 20.00 11.26 61 332045 2098 29618274
Flushing 19.82 11.26 220 331886 29272 29591100
Hypercreatininaemia 19.81 11.26 26 332080 472 29619900
Haemophagocytic lymphohistiocytosis 19.80 11.26 50 332056 9741 29610631
Incorrect route of product administration 19.76 11.26 62 332044 11253 29609119
Pulmonary tuberculosis 19.68 11.26 15 332091 4842 29615530
Hepatitis B 19.63 11.26 23 332083 6049 29614323
Eye pain 19.62 11.26 66 332040 11723 29608649
Hepatitis B reactivation 19.60 11.26 4 332102 2873 29617499
Road traffic accident 19.59 11.26 110 331996 16961 29603411
Mood swings 19.58 11.26 34 332072 7592 29612780
Gastrointestinal vascular malformation haemorrhagic 19.54 11.26 27 332079 516 29619856
Blood uric acid increased 19.52 11.26 124 331982 5899 29614473
Bone pain 19.52 11.26 127 331979 18899 29601473
Gastrointestinal angiodysplasia 19.48 11.26 26 332080 480 29619892
Syringe issue 19.48 11.26 4 332102 2861 29617511
Diabetic nephropathy 19.41 11.26 55 332051 1814 29618558
Dermatitis exfoliative generalised 19.40 11.26 72 332034 2743 29617629
Prerenal failure 19.37 11.26 55 332051 1816 29618556
Feeling abnormal 19.34 11.26 480 331626 56276 29564096
Cardio-respiratory distress 19.30 11.26 15 332091 139 29620233
Intraocular pressure increased 19.27 11.26 17 332089 5103 29615269
Metabolic acidosis 19.25 11.26 548 331558 36913 29583459
Abnormal dreams 19.23 11.26 38 332068 8077 29612295
Injection site mass 19.19 11.26 16 332090 4937 29615435
Hypersensitivity vasculitis 19.15 11.26 87 332019 3636 29616736
Emotional disorder 19.07 11.26 17 332089 5077 29615295
Virologic failure 18.99 11.26 6 332100 3213 29617159
Visual impairment 18.93 11.26 231 331875 30207 29590165
Crepitations 18.91 11.26 75 332031 2949 29617423
Dilatation ventricular 18.85 11.26 69 332037 2611 29617761
Varices oesophageal 18.80 11.26 83 332023 3426 29616946
Scrotal oedema 18.68 11.26 47 332059 1442 29618930
Muscle haemorrhage 18.65 11.26 86 332020 3617 29616755
Drug abuser 18.60 11.26 13 332093 4388 29615984
Second primary malignancy 18.55 11.26 26 332080 6330 29614042
Speech disorder 18.46 11.26 178 331928 24334 29596038
Pulmonary arterial pressure increased 18.43 11.26 39 332067 1065 29619307
Catatonia 18.43 11.26 13 332093 4367 29616005
Atrioventricular block first degree 18.37 11.26 117 331989 5571 29614801
Hypocalcaemia 18.29 11.26 336 331770 21040 29599332
Packed red blood cell transfusion 18.29 11.26 48 332058 1512 29618860
Toxic epidermal necrolysis 18.26 11.26 290 331816 17650 29602722
Occult blood positive 17.96 11.26 86 332020 3674 29616698
Hypogammaglobulinaemia 17.96 11.26 19 332087 5233 29615139
Posthaemorrhagic hydrocephalus 17.91 11.26 12 332094 86 29620286
Upper motor neurone lesion 17.87 11.26 13 332093 108 29620264
Microcytic anaemia 17.86 11.26 59 332047 2119 29618253
Left ventricular hypertrophy 17.79 11.26 125 331981 6153 29614219
Feeling hot 17.74 11.26 100 332006 15404 29604968
Cardiac ablation 17.72 11.26 27 332079 566 29619806
Bronchopulmonary aspergillosis 17.68 11.26 73 332033 12211 29608161
Ventricular hypokinesia 17.65 11.26 93 332013 4130 29616242
Enteritis 17.64 11.26 29 332077 6616 29613756
Chronic graft versus host disease 17.63 11.26 12 332094 4107 29616265
Impaired work ability 17.58 11.26 22 332084 5621 29614751
Drug-induced liver injury 17.54 11.26 151 331955 21123 29599249
Bone marrow failure 17.42 11.26 229 331877 29556 29590816
Low cardiac output syndrome 17.34 11.26 20 332086 316 29620056
Ischaemic stroke 17.29 11.26 265 331841 16010 29604362
C-reactive protein abnormal 17.22 11.26 22 332084 5571 29614801
Injection site pruritus 17.21 11.26 22 332084 5570 29614802
Viral mutation identified 17.18 11.26 4 332102 2622 29617750
Arteriospasm coronary 17.10 11.26 4 332102 2614 29617758
Atrial septal defect 17.10 11.26 30 332076 6671 29613701
Spontaneous haematoma 17.08 11.26 25 332081 505 29619867
Tendonitis 17.07 11.26 40 332066 7996 29612376
Adverse drug reaction 17.04 11.26 169 331937 22976 29597396
Aortic valve incompetence 16.99 11.26 103 332003 4820 29615552
Dermatitis bullous 16.99 11.26 121 331985 5983 29614389
Hepatic enzyme increased 16.96 11.26 265 331841 33229 29587143
Maternal exposure during pregnancy 16.95 11.26 11 332095 3860 29616512
Frequent bowel movements 16.94 11.26 43 332063 8362 29612010
Product substitution issue 16.82 11.26 56 332050 9979 29610393
Cellulitis 16.77 11.26 656 331450 46128 29574244
Pruritus 16.77 11.26 1107 330999 117097 29503275
Gastritis erosive 16.64 11.26 113 331993 5500 29614872
Coagulation time prolonged 16.59 11.26 40 332066 1194 29619178
Respiratory distress 16.58 11.26 481 331625 32491 29587881
Gastritis haemorrhagic 16.55 11.26 39 332067 1147 29619225
Post procedural haematoma 16.53 11.26 46 332060 1501 29618871
Graft versus host disease in skin 16.49 11.26 8 332098 3299 29617073
Hypervolaemia 16.49 11.26 53 332053 1876 29618496
Knee arthroplasty 16.46 11.26 23 332083 5607 29614765
Multiple-drug resistance 16.45 11.26 6 332100 2935 29617437
Paracentesis 16.43 11.26 21 332085 371 29620001
Alcohol interaction 16.38 11.26 5 332101 2737 29617635
Gastric varices 16.34 11.26 21 332085 373 29619999
Crying 16.32 11.26 23 332083 5586 29614786
Left ventricle outflow tract obstruction 16.26 11.26 13 332093 126 29620246
Cardiac asthma 16.21 11.26 10 332096 61 29620311
Renal artery thrombosis 16.19 11.26 19 332087 306 29620066
Delusion 16.18 11.26 73 332033 11916 29608456
Ventricular dyssynchrony 16.16 11.26 7 332099 17 29620355
Acquired macroglossia 16.16 11.26 7 332099 17 29620355
Lymphopenia 16.11 11.26 83 332023 13080 29607292
Inflammatory bowel disease 16.01 11.26 3 332103 2290 29618082
Base excess decreased 15.99 11.26 16 332090 213 29620159
Graft versus host disease in gastrointestinal tract 15.96 11.26 7 332099 3062 29617310
Faeces discoloured 15.96 11.26 230 331876 13716 29606656
Anticoagulation drug level increased 15.96 11.26 24 332082 497 29619875
Polyneuropathy 15.95 11.26 72 332034 11751 29608621
Weight decreased 15.84 11.26 1449 330657 149472 29470900
Hypoperfusion 15.83 11.26 36 332070 1034 29619338
Cardioactive drug level decreased 15.83 11.26 10 332096 64 29620308
Restlessness 15.82 11.26 167 331939 22432 29597940
Ecchymosis 15.73 11.26 125 331981 6397 29613975
Posterior reversible encephalopathy syndrome 15.71 11.26 47 332059 8660 29611712
Small for dates baby 15.63 11.26 8 332098 3200 29617172
Hepatic steatosis 15.56 11.26 98 332008 14695 29605677
Haemoptysis 15.52 11.26 453 331653 30625 29589747
Therapy partial responder 15.47 11.26 11 332095 3680 29616692
Ammonia increased 15.45 11.26 90 332016 4151 29616221
Hypochromasia 15.37 11.26 19 332087 324 29620048
Myocarditis 15.36 11.26 58 332048 9953 29610419
Oxygen consumption decreased 15.34 11.26 14 332092 165 29620207
Anal fistula 15.29 11.26 13 332093 3973 29616399
Exercise tolerance decreased 15.28 11.26 83 332023 3729 29616643
Gastrointestinal tract mucosal pigmentation 15.25 11.26 16 332090 226 29620146
Cardiospasm 15.25 11.26 5 332101 3 29620369
Thirst decreased 15.25 11.26 5 332101 3 29620369
Alanine aminotransferase abnormal 15.24 11.26 5 332101 2614 29617758
Status epilepticus 15.20 11.26 67 332039 11005 29609367
Purpura 15.05 11.26 173 331933 9794 29610578
Candida infection 15.03 11.26 104 332002 15258 29605114
Asterixis 15.03 11.26 39 332067 1220 29619152
Haematoma muscle 15.00 11.26 25 332081 567 29619805
Bipolar disorder 14.87 11.26 12 332094 3764 29616608
Peripheral vascular disorder 14.84 11.26 104 332002 5115 29615257
Abdominal cavity drainage 14.81 11.26 19 332087 337 29620035
Lividity 14.71 11.26 12 332094 120 29620252
Cytomegalovirus chorioretinitis 14.70 11.26 9 332097 3259 29617113
Atrial enlargement 14.68 11.26 11 332095 96 29620276
Left atrial enlargement 14.65 11.26 22 332084 455 29619917
Right atrial enlargement 14.61 11.26 16 332090 238 29620134
Pulmonary congestion 14.60 11.26 204 331902 12083 29608289
Strongyloidiasis 14.52 11.26 4 332102 2342 29618030
Liver palpable 14.44 11.26 9 332097 56 29620316
Unintentional medical device removal 14.44 11.26 3 332103 2128 29618244
International normalised ratio abnormal 14.34 11.26 71 332035 3075 29617297
Pseudo-Bartter syndrome 14.31 11.26 6 332100 13 29620359
Neonatal respiratory distress syndrome 14.30 11.26 14 332092 3998 29616374
COVID-19 14.25 11.26 128 331978 17750 29602622
Dyspnoea at rest 14.23 11.26 62 332044 2544 29617828
Photophobia 14.11 11.26 27 332079 5809 29614563
Medication error 14.08 11.26 318 331788 20654 29599718
Ejection fraction 14.07 11.26 9 332097 59 29620313
Alkalosis 14.06 11.26 11 332095 103 29620269
Left ventricular end-diastolic pressure increased 14.06 11.26 11 332095 103 29620269
Phlebitis deep 14.01 11.26 6 332100 14 29620358
Gouty arthritis 13.98 11.26 34 332072 1021 29619351
Angina pectoris 13.86 11.26 427 331679 29091 29591281
Cystic fibrosis 13.85 11.26 4 332102 2270 29618102
Abscess 13.82 11.26 61 332045 10017 29610355
Hypercreatinaemia 13.81 11.26 11 332095 106 29620266
Hypertriglyceridaemia 13.71 11.26 45 332061 8053 29612319
Middle insomnia 13.71 11.26 27 332079 5746 29614626
Abdominal distension 13.69 11.26 629 331477 45080 29575292
Head injury 13.69 11.26 265 331841 16755 29603617
Hepatic vein dilatation 13.69 11.26 5 332101 6 29620366
Diabetes with hyperosmolarity 13.69 11.26 5 332101 6 29620366
Adult failure to thrive 13.69 11.26 5 332101 6 29620366
Sinus node dysfunction 13.64 11.26 81 332025 3762 29616610
Pulmonary vein stenosis 13.62 11.26 8 332098 44 29620328
Hallucination 13.61 11.26 427 331679 48632 29571740
Pruritus genital 13.55 11.26 21 332085 447 29619925
Muscle rigidity 13.54 11.26 63 332043 10198 29610174
Ventricular dysfunction 13.48 11.26 78 332028 3589 29616783
Portopulmonary hypertension 13.46 11.26 6 332100 16 29620356
Throat irritation 13.46 11.26 49 332057 8499 29611873
Heparin-induced thrombocytopenia 13.44 11.26 104 332002 5279 29615093
Central nervous system lesion 13.41 11.26 21 332085 4885 29615487
Coronary arterial stent insertion 13.38 11.26 86 332020 4108 29616264
Affective disorder 13.38 11.26 9 332097 3099 29617273
Pulmonary embolism 13.34 11.26 719 331387 77416 29542956
Dysmorphism 13.34 11.26 3 332103 2014 29618358
Amyloidosis 13.34 11.26 53 332053 2086 29618286
Hyperparathyroidism secondary 13.33 11.26 36 332070 1154 29619218
Uraemic encephalopathy 13.29 11.26 16 332090 265 29620107
International normalised ratio fluctuation 13.23 11.26 33 332073 1007 29619365
Blindness 13.22 11.26 81 332025 12228 29608144
Hypercalciuria 13.22 11.26 14 332092 200 29620172
Electrocardiogram QRS complex abnormal 13.20 11.26 16 332090 267 29620105
Scrotal swelling 13.12 11.26 39 332067 1322 29619050
Visual field defect 13.09 11.26 18 332088 4418 29615954
Acute lymphocytic leukaemia 13.08 11.26 9 332097 3063 29617309
Base excess increased 13.07 11.26 8 332098 48 29620324
Ventricular internal diameter abnormal 13.07 11.26 8 332098 48 29620324
Melanoderma 13.06 11.26 13 332093 172 29620200
Upper respiratory tract infection 13.04 11.26 220 331886 27256 29593116
Blood creatinine abnormal 13.03 11.26 51 332055 1993 29618379
Creatinine renal clearance decreased 13.02 11.26 73 332033 3320 29617052
Device use error 12.99 11.26 3 332103 1978 29618394
Subarachnoid haemorrhage 12.93 11.26 167 331939 9719 29610653
Cardiac failure high output 12.92 11.26 7 332099 32 29620340
Squamous cell carcinoma 12.90 11.26 64 332042 10186 29610186
Blood chloride increased 12.86 11.26 59 332047 2476 29617896
Oxygen saturation increased 12.80 11.26 14 332092 208 29620164
Degenerative aortic valve disease 12.73 11.26 6 332100 19 29620353
Social avoidant behaviour 12.72 11.26 8 332098 2855 29617517
Diabetic foot 12.55 11.26 62 332044 2683 29617689
Endocarditis 12.55 11.26 112 331994 5931 29614441
Haemorrhagic arteriovenous malformation 12.54 11.26 18 332088 357 29620015
Blood urea abnormal 12.53 11.26 25 332081 654 29619718
Gastrointestinal arteriovenous malformation 12.50 11.26 18 332088 358 29620014
Ear infection 12.46 11.26 41 332065 7333 29613039
Viral infection 12.42 11.26 108 331998 15077 29605295
Alanine aminotransferase increased 12.40 11.26 685 331421 73591 29546781
Long QT syndrome 12.36 11.26 55 332051 2278 29618094
Dissociation 12.34 11.26 34 332072 1103 29619269
Haematocrit decreased 12.34 11.26 436 331670 30263 29590109
Activated partial thromboplastin time prolonged 12.33 11.26 137 331969 7691 29612681
Tachycardia induced cardiomyopathy 12.25 11.26 9 332097 76 29620296
Gouty tophus 12.23 11.26 11 332095 127 29620245
Ectopic gastric mucosa 12.18 11.26 5 332101 10 29620362
Mumps 12.10 11.26 10 332096 102 29620270
Dizziness 12.10 11.26 2393 329713 192516 29427856
Shoshin beriberi 12.09 11.26 8 332098 56 29620316
Right-to-left cardiac shunt 12.08 11.26 6 332100 22 29620350
Pericardial drainage 12.06 11.26 9 332097 78 29620294
Cheyne-Stokes respiration 12.05 11.26 14 332092 223 29620149
Cerebral haemorrhage 11.99 11.26 462 331644 32425 29587947
Cytokine release syndrome 11.95 11.26 63 332043 9870 29610502
Mydriasis 11.94 11.26 32 332074 6111 29614261
Hypoalbuminaemia 11.94 11.26 181 331925 10911 29609461
Adenovirus infection 11.93 11.26 18 332088 4250 29616122
Pulmonary hypertensive crisis 11.86 11.26 12 332094 162 29620210
Hypertensive cardiomyopathy 11.75 11.26 12 332094 164 29620208
Troponin increased 11.75 11.26 150 331956 8707 29611665
Transaminases increased 11.74 11.26 186 331920 23271 29597101
Blood luteinising hormone increased 11.70 11.26 9 332097 82 29620290
Neuralgia 11.70 11.26 68 332038 10398 29609974
Fabry's disease 11.69 11.26 6 332100 24 29620348
Tic 11.62 11.26 4 332102 2028 29618344
Hyperaldosteronism 11.57 11.26 10 332096 109 29620263
Diverticulum intestinal haemorrhagic 11.56 11.26 50 332056 2045 29618327
Dermatitis exfoliative 11.52 11.26 130 331976 7326 29613046
Death 11.52 11.26 3665 328441 353618 29266754
Pulseless electrical activity 11.51 11.26 112 331994 6075 29614297
Osteoarthritis 11.51 11.26 139 331967 18210 29602162
Attention deficit hyperactivity disorder 11.50 11.26 3 332103 1821 29618551
Tongue oedema 11.46 11.26 61 332045 2719 29617653
Conjunctival scar 11.44 11.26 8 332098 62 29620310
Peripheral arterial occlusive disease 11.36 11.26 97 332009 5071 29615301
Gastric ulcer 11.35 11.26 233 331873 14888 29605484
Antipsychotic drug level increased 11.34 11.26 11 332095 3155 29617217
Viral load increased 11.33 11.26 9 332097 2845 29617527
Squamous cell carcinoma of skin 11.33 11.26 57 332049 9038 29611334
Malignant melanoma 11.33 11.26 43 332063 7368 29613004
Cataract 11.31 11.26 172 331934 21663 29598709
Papilloedema 11.30 11.26 6 332100 2350 29618022
Ketoacidosis 11.26 11.26 15 332091 3731 29616641

Pharmacologic Action:

SourceCodeDescription
ATC C03CA01 CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Sulfonamides, plain
ATC C03CB01 CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Sulfonamides and potassium in combination
ATC C03EB01 CARDIOVASCULAR SYSTEM
DIURETICS
DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
High-ceiling diuretics and potassium-sparing agents
FDA PE N0000175366 Increased Diuresis at Loop of Henle
FDA EPC N0000175590 Loop Diuretic
MeSH PA D004232 Diuretics
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D045283 Natriuretic Agents
MeSH PA D049994 Sodium Potassium Chloride Symporter Inhibitors
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:77608 loop diuretics
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Acute pulmonary edema indication 40541001
Decompensated cardiac failure indication 195111005
Edema indication 267038008
Pulmonary Edema due to Chronic Heart Failure indication
Edema due to Hepatic Cirrhosis indication
Peripheral Edema due to Chronic Heart Failure indication
Hypercalcemia off-label use 66931009 DOID:12678
Prevention of Oliguria off-label use
Metabolic alkalosis contraindication 1388004
Anuria contraindication 2472002 DOID:2983
Hypocalcemia contraindication 5291005
Hypochloremia contraindication 10399008
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Diabetes mellitus contraindication 73211009 DOID:9351
Pancreatitis contraindication 75694006 DOID:4989
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Hearing disorder contraindication 128540005
Hypomagnesemia contraindication 190855004
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Azotemia contraindication 445009001

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.69 acidic
pKa2 10.59 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Solute carrier family 12 member 1 Transporter INHIBITOR IC50 6.20 WOMBAT-PK CHEMBL
Carbonic anhydrase 2 Enzyme Ki 7.19 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 6.58 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 6.25 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme IC50 5.42 CHEMBL
G-protein coupled receptor 35 GPCR Ki 5.49 CHEMBL
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 6.30 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 7.28 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 6.29 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 6.38 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 7.21 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 6.49 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 6.61 CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-1 Transporter WOMBAT-PK
Solute carrier family 12 member 2 Transporter INHIBITOR IC50 5.13 IUPHAR
Carbonic anhydrase 13 Enzyme Ki 6.26 CHEMBL
Holo-[acyl-carrieir-protein] synthase Unclassified IC50 4.90 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme IC50 5.42 CHEMBL

External reference:

IDSource
4017830 VUID
N0000146188 NUI
D00331 KEGG_DRUG
4017830 VANDF
C0016860 UMLSCUI
CHEBI:47426 CHEBI
FUN PDB_CHEM_ID
CHEMBL35 ChEMBL_ID
CHEMBL1788133 ChEMBL_ID
DB00695 DRUGBANK_ID
D005665 MESH_DESCRIPTOR_UI
4839 IUPHAR_LIGAND_ID
1584 INN_ID
7LXU5N7ZO5 UNII
3440 PUBCHEM_CID
4603 RXNORM
3962 MMSL
4769 MMSL
d00070 MMSL
002307 NDDF
387475002 SNOMEDCT_US
81609008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-3294 SOLUTION 10 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-3298 SOLUTION 40 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4297 TABLET 20 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4299 TABLET 40 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4301 TABLET 80 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8297 TABLET 20 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8299 TABLET 40 mg ORAL NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8301 TABLET 80 mg ORAL ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0208 TABLET 20 mg ORAL NDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0216 TABLET 40 mg ORAL NDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0232 TABLET 80 mg ORAL ANDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0409-1639 INJECTION, SOLUTION 10 mg INTRAMUSCULAR ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0409-6102 INJECTION, SOLUTION 10 mg INTRAMUSCULAR NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0409-6102 INJECTION, SOLUTION 10 mg INTRAMUSCULAR NDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0409-9631 INJECTION, SOLUTION 10 mg INTRAMUSCULAR ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7937 TABLET 20 mg ORAL NDA 11 sections
Fuosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7938 TABLET 40 mg ORAL NDA 11 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7957 TABLET 80 mg ORAL ANDA 11 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-8368 TABLET 20 mg ORAL ANDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-8369 TABLET 40 mg ORAL ANDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-8370 TABLET 80 mg ORAL ANDA 22 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 10544-131 TABLET 20 mg ORAL ANDA 13 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 10544-584 TABLET 40 mg ORAL ANDA 13 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 12634-416 TABLET 20 mg ORAL ANDA 18 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 12634-533 TABLET 40 mg ORAL ANDA 18 sections
FUROSEMIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-284 TABLET 40 mg ORAL ANDA 18 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 16729-500 INJECTION 10 mg INTRAMUSCULAR ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 16729-501 INJECTION 10 mg INTRAMUSCULAR ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 16729-502 INJECTION 10 mg INTRAMUSCULAR ANDA 21 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 17856-3298 SOLUTION 40 mg ORAL ANDA 12 sections