furosemide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diuretics, furosemide derivatives 1258 54-31-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • frusemide
  • furosemide
  • furosemid
A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
  • Molecular weight: 330.74
  • Formula: C12H11ClN2O5S
  • CLOGP: 1.90
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 122.63
  • ALOGS: -3.45
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
40 mg O
40 mg P
40 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 66 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 25.92 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 71 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.12 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 1, 1966 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 5327.75 33.86 1482 8460 26640 2321503
Hyponatraemia 3298.27 33.86 873 9069 12452 2335691
Hypokalaemia 2896.82 33.86 753 9189 9901 2338242
Dehydration 1837.50 33.86 627 9315 21668 2326475
Hypotension 1781.12 33.86 675 9267 31761 2316382
Hyperkalaemia 1685.09 33.86 435 9507 5458 2342685
Fall 1481.92 33.86 658 9284 46441 2301702
Syncope 1164.90 33.86 417 9525 16458 2331685
Drug interaction 1115.56 33.86 469 9473 28694 2319449
Cardiac failure 852.61 33.86 304 9638 11790 2336353
Renal failure 783.88 33.86 315 9627 17034 2331109
Dyspnoea 781.26 33.86 512 9430 78221 2269922
Toxic epidermal necrolysis 742.87 33.86 200 9742 2944 2345199
Confusional state 662.38 33.86 309 9633 24035 2324108
Electrocardiogram QT prolonged 660.10 33.86 225 9717 7589 2340554
Renal impairment 659.37 33.86 240 9702 9852 2338291
Bradycardia 613.63 33.86 227 9715 9754 2338389
Blood creatinine increased 605.36 33.86 228 9714 10305 2337838
Toxicity to various agents 598.07 33.86 317 9625 32437 2315706
Orthostatic hypotension 577.15 33.86 161 9781 2718 2345425
Completed suicide 547.08 33.86 259 9683 20775 2327368
Oedema peripheral 537.82 33.86 266 9676 23497 2324646
Torsade de pointes 535.58 33.86 144 9798 2102 2346041
Malaise 514.09 33.86 347 9595 55238 2292905
Metabolic alkalosis 499.42 33.86 97 9845 262 2347881
Asthenia 487.13 33.86 315 9627 46611 2301532
Vomiting 461.28 33.86 359 9583 71243 2276900
Diarrhoea 443.36 33.86 374 9568 83190 2264953
Condition aggravated 439.47 33.86 257 9685 31722 2316421
Dizziness 421.17 33.86 314 9628 58351 2289792
Atrial fibrillation 418.25 33.86 189 9753 13579 2334564
Oedema 407.74 33.86 170 9772 10033 2338110
Anaemia 401.54 33.86 250 9692 34542 2313601
Somnolence 396.18 33.86 216 9726 23269 2324874
Hypomagnesaemia 378.21 33.86 113 9829 2451 2345692
Electrolyte imbalance 345.29 33.86 100 9842 1937 2346206
Blood sodium decreased 336.43 33.86 108 9834 2992 2345151
Blood urea increased 336.31 33.86 112 9830 3493 2344650
Presyncope 326.50 33.86 111 9831 3692 2344451
Overdose 321.48 33.86 178 9764 19729 2328414
Nausea 310.86 33.86 352 9590 111837 2236306
Decreased appetite 306.48 33.86 197 9745 28694 2319449
Loss of consciousness 306.28 33.86 169 9773 18598 2329545
Drug ineffective 305.77 33.86 333 9609 101291 2246852
General physical health deterioration 300.71 33.86 152 9790 13987 2334156
Lactic acidosis 297.11 33.86 113 9829 5217 2342926
Pneumonia aspiration 297.02 33.86 103 9839 3639 2344504
Stevens-Johnson syndrome 283.98 33.86 103 9839 4156 2343987
Hypocalcaemia 278.04 33.86 99 9843 3784 2344359
Blood potassium decreased 276.12 33.86 107 9835 5198 2342945
Cardiac arrest 275.74 33.86 146 9796 14784 2333359
Multiple organ dysfunction syndrome 270.80 33.86 117 9825 7524 2340619
Metabolic acidosis 270.27 33.86 109 9833 5889 2342254
Hypertension 266.70 33.86 177 9765 27184 2320959
Pulmonary oedema 265.06 33.86 114 9828 7249 2340894
Medication error 257.70 33.86 106 9836 6025 2342118
Rhabdomyolysis 248.56 33.86 106 9836 6598 2341545
Oliguria 245.03 33.86 70 9872 1287 2346856
Hypochloraemia 236.09 33.86 51 9891 266 2347877
International normalised ratio increased 232.95 33.86 104 9838 7232 2340911
Nephrocalcinosis 230.49 33.86 46 9896 149 2347994
Premature delivery 223.07 33.86 80 9862 3120 2345023
Coma 221.05 33.86 107 9835 8949 2339194
Pseudo-Bartter syndrome 220.30 33.86 35 9907 6 2348137
Drug abuse 217.43 33.86 116 9826 11910 2336233
Maternal exposure during pregnancy 212.96 33.86 123 9819 14740 2333403
Cardiac failure congestive 206.42 33.86 124 9818 15977 2332166
Blood potassium increased 203.82 33.86 68 9874 2128 2346015
Hypernatraemia 202.07 33.86 55 9887 839 2347304
Chronic kidney disease 199.92 33.86 79 9863 4039 2344104
Blister 199.12 33.86 91 9851 6680 2341463
Pruritus 194.43 33.86 177 9765 43163 2304980
Gastrooesophageal reflux disease 193.85 33.86 98 9844 8997 2339146
Sopor 191.69 33.86 76 9866 3919 2344224
Anuria 191.50 33.86 62 9880 1762 2346381
Cardioactive drug level increased 189.63 33.86 43 9899 290 2347853
Blood pressure decreased 186.62 33.86 96 9846 9140 2339003
Pemphigoid 183.32 33.86 52 9890 930 2347213
Drug hypersensitivity 183.32 33.86 177 9765 46466 2301677
Exposure during pregnancy 180.11 33.86 135 9807 25084 2323059
Hypovolaemia 177.22 33.86 53 9889 1150 2346993
Fatigue 167.32 33.86 225 9717 84648 2263495
Circulatory collapse 165.41 33.86 67 9875 3653 2344490
Chest pain 164.89 33.86 134 9808 28003 2320140
Pneumonia 164.14 33.86 171 9771 49125 2299018
Hepatitis 157.98 33.86 76 9866 6261 2341882
Ventricular tachycardia 157.54 33.86 61 9881 2950 2345193
Erythema 156.28 33.86 124 9818 25035 2323108
Thrombocytopenia 156.00 33.86 111 9831 19020 2329123
Gait disturbance 154.98 33.86 118 9824 22427 2325716
Pyrexia 153.72 33.86 172 9770 53536 2294607
Delirium 149.78 33.86 69 9873 5154 2342989
Agranulocytosis 148.95 33.86 61 9881 3421 2344722
Toxic skin eruption 148.12 33.86 54 9888 2206 2345937
Drug reaction with eosinophilia and systemic symptoms 146.16 33.86 69 9873 5449 2342694
Haematoma 144.81 33.86 67 9875 5054 2343089
Urine output decreased 144.78 33.86 48 9894 1471 2346672
Hypoglycaemia 143.22 33.86 78 9864 8329 2339814
Balance disorder 143.08 33.86 82 9860 9665 2338478
Fluid retention 141.61 33.86 73 9869 6973 2341170
Urinary tract infection 141.42 33.86 126 9816 29816 2318327
Shock haemorrhagic 140.34 33.86 45 9897 1238 2346905
Abdominal pain 135.93 33.86 131 9811 34243 2313900
Interstitial lung disease 134.52 33.86 73 9869 7739 2340404
Constipation 132.99 33.86 106 9836 21523 2326620
Cholestasis 131.79 33.86 57 9885 3664 2344479
Lethargy 129.62 33.86 74 9868 8656 2339487
Cardio-respiratory arrest 129.06 33.86 75 9867 9071 2339072
Ventricular fibrillation 127.38 33.86 48 9894 2153 2345990
Weight decreased 127.27 33.86 116 9826 28255 2319888
Pleural effusion 126.94 33.86 81 9861 11587 2336556
Hepatocellular injury 123.90 33.86 56 9886 3999 2344144
Eosinophilia 123.52 33.86 51 9891 2919 2345224
Drug level increased 123.21 33.86 50 9892 2737 2345406
Premature baby 123.11 33.86 52 9890 3152 2344991
Respiratory failure 123.11 33.86 84 9858 13444 2334699
Headache 120.41 33.86 187 9755 79992 2268151
Cough 119.35 33.86 120 9822 32997 2315146
Pulmonary hypertension 117.40 33.86 58 9884 5060 2343083
Melaena 116.95 33.86 54 9888 4052 2344091
Vertigo 116.87 33.86 71 9871 9313 2338830
Disorientation 116.57 33.86 62 9880 6310 2341833
Tubulointerstitial nephritis 115.59 33.86 46 9896 2392 2345751
Gastrointestinal haemorrhage 112.64 33.86 77 9865 12358 2335785
Depressed level of consciousness 108.98 33.86 63 9879 7541 2340602
Sepsis 108.08 33.86 88 9854 18400 2329743
Asphyxia 104.84 33.86 34 9908 970 2347173
Foetal exposure during pregnancy 104.32 33.86 54 9888 5198 2342945
Mitral valve incompetence 103.37 33.86 43 9899 2507 2345636
Arrhythmia 102.84 33.86 56 9886 5972 2342171
Low birth weight baby 102.79 33.86 32 9910 797 2347346
Rash 102.27 33.86 148 9794 59410 2288733
Cardiac failure acute 102.13 33.86 34 9908 1055 2347088
Bradyphrenia 101.82 33.86 34 9908 1065 2347078
Weight increased 101.44 33.86 92 9850 22245 2325898
Hyperthyroidism 100.93 33.86 40 9902 2057 2346086
Rash maculo-papular 99.94 33.86 49 9893 4203 2343940
Cleft palate 99.91 33.86 24 9918 214 2347929
Arteriosclerosis coronary artery 99.65 33.86 34 9908 1139 2347004
Hyperuricaemia 99.30 33.86 29 9913 577 2347566
Cardiac murmur 99.15 33.86 37 9905 1614 2346529
Muscular weakness 97.96 33.86 76 9866 14821 2333322
Septic shock 97.26 33.86 57 9885 6997 2341146
Tachycardia 95.68 33.86 78 9864 16331 2331812
Hyponatraemic syndrome 95.36 33.86 20 9922 88 2348055
Alanine aminotransferase increased 95.35 33.86 73 9869 13959 2334184
Dermatitis bullous 95.07 33.86 35 9907 1469 2346674
Lower respiratory tract infection 94.22 33.86 51 9891 5373 2342770
Product prescribing error 93.99 33.86 42 9900 2918 2345225
Dermatitis exfoliative 93.93 33.86 33 9909 1208 2346935
Respiratory disorder 93.68 33.86 46 9896 3958 2344185
Blood pressure increased 93.32 33.86 78 9864 16908 2331235
Dysmorphism 91.65 33.86 25 9917 384 2347759
Cardiogenic shock 90.96 33.86 39 9903 2452 2345691
Hypovolaemic shock 90.86 33.86 29 9913 785 2347358
Treatment noncompliance 90.51 33.86 50 9892 5484 2342659
Head injury 90.38 33.86 45 9897 3989 2344154
Cognitive disorder 89.05 33.86 49 9893 5332 2342811
Creatinine renal clearance decreased 87.50 33.86 29 9913 887 2347256
Hypercalcaemia 86.22 33.86 38 9904 2554 2345589
Renal tubular necrosis 85.96 33.86 33 9909 1557 2346586
Acidosis 85.56 33.86 33 9909 1577 2346566
Product complaint 85.38 33.86 45 9897 4493 2343650
Peripheral swelling 84.86 33.86 75 9867 17522 2330621
Hallucination 84.72 33.86 55 9887 8093 2340050
Acute generalised exanthematous pustulosis 84.62 33.86 33 9909 1625 2346518
Acute motor-sensory axonal neuropathy 84.39 33.86 16 9926 36 2348107
Ascites 84.36 33.86 48 9894 5572 2342571
Long QT syndrome 83.32 33.86 25 9917 548 2347595
Hypoxia 82.39 33.86 49 9893 6178 2341965
Ischaemic stroke 82.38 33.86 40 9902 3357 2344786
Blood chloride decreased 82.31 33.86 26 9916 680 2347463
Aspartate aminotransferase increased 82.16 33.86 64 9878 12548 2335595
Intentional overdose 81.56 33.86 61 9881 11260 2336883
Rales 81.46 33.86 29 9913 1104 2347039
Prerenal failure 80.57 33.86 20 9922 207 2347936
Death 80.34 33.86 158 9784 81310 2266833
Orthopnoea 80.21 33.86 25 9917 625 2347518
Sinus bradycardia 80.14 33.86 34 9908 2082 2346061
Muscle spasms 79.18 33.86 79 9863 21487 2326656
Cyanosis 78.74 33.86 38 9904 3147 2344996
Haemodialysis 77.55 33.86 33 9909 2036 2346107
Inappropriate antidiuretic hormone secretion 77.28 33.86 34 9908 2275 2345868
Haemoglobin decreased 77.01 33.86 72 9870 18079 2330064
Renal tubular disorder 76.83 33.86 23 9919 500 2347643
Hyperglycaemia 76.77 33.86 43 9899 4842 2343301
Urinary retention 76.56 33.86 39 9903 3628 2344515
Shock 76.16 33.86 40 9902 3964 2344179
Nikolsky's sign 75.03 33.86 17 9925 114 2348029
Coma scale abnormal 74.56 33.86 25 9917 793 2347350
C-reactive protein increased 74.46 33.86 46 9896 6209 2341934
Seizure 74.36 33.86 81 9861 24385 2323758
Encephalopathy 74.00 33.86 41 9901 4520 2343623
Hypophagia 73.36 33.86 39 9903 3961 2344182
Palpitations 73.14 33.86 67 9875 16389 2331754
Rash macular 72.11 33.86 37 9905 3494 2344649
Lip erosion 71.97 33.86 17 9925 140 2348003
Wound 71.86 33.86 34 9908 2694 2345449
Multiple fractures 71.73 33.86 23 9919 632 2347511
Atrioventricular block complete 71.65 33.86 28 9914 1386 2346757
Dysarthria 71.62 33.86 45 9897 6257 2341886
Tricuspid valve incompetence 70.76 33.86 29 9913 1627 2346516
Myalgia 70.47 33.86 77 9865 23256 2324887
Haematemesis 69.83 33.86 38 9904 4044 2344099
Agitation 69.64 33.86 55 9887 10996 2337147
Polyuria 69.19 33.86 26 9916 1156 2346987
Arthralgia 68.24 33.86 117 9825 54168 2293975
Right ventricular failure 68.18 33.86 31 9911 2242 2345901
Hepatic failure 68.13 33.86 42 9900 5647 2342496
Fluid overload 67.92 33.86 33 9909 2773 2345370
Limb reduction defect 66.13 33.86 14 9928 65 2348078
Abdominal distension 66.00 33.86 52 9890 10359 2337784
Electrocardiogram abnormal 65.87 33.86 26 9916 1322 2346821
Pancytopenia 65.81 33.86 54 9888 11398 2336745
Azotaemia 65.25 33.86 21 9921 584 2347559
Abdominal pain upper 63.40 33.86 71 9871 22029 2326114
Urinary incontinence 63.11 33.86 36 9906 4197 2343946
Deafness 63.08 33.86 31 9911 2670 2345473
Alkalosis hypochloraemic 62.86 33.86 11 9931 12 2348131
Product administration error 62.75 33.86 35 9907 3908 2344235
Cholelithiasis 62.36 33.86 40 9902 5763 2342380
Proteinuria 61.50 33.86 31 9911 2819 2345324
Hepatic encephalopathy 61.45 33.86 26 9916 1581 2346562
Hypercholesterolaemia 61.28 33.86 26 9916 1592 2346551
Bradykinesia 60.99 33.86 20 9922 591 2347552
Pain 60.93 33.86 120 9822 61737 2286406
Pancreatitis acute 60.77 33.86 34 9908 3819 2344324
Visual impairment 60.47 33.86 52 9890 11703 2336440
Blood calcium decreased 60.24 33.86 28 9914 2130 2346013
Hallucination, visual 60.21 33.86 31 9911 2948 2345195
Acute respiratory distress syndrome 60.09 33.86 32 9910 3260 2344883
Diabetic metabolic decompensation 60.01 33.86 15 9927 160 2347983
Mucosal erosion 59.89 33.86 16 9926 226 2347917
Myocardial infarction 59.59 33.86 64 9878 18949 2329194
Pancreatitis 59.22 33.86 44 9898 8035 2340108
Blood creatine phosphokinase increased 59.18 33.86 37 9905 5099 2343044
Atrial septal defect 59.00 33.86 24 9918 1320 2346823
Wheezing 58.88 33.86 40 9902 6344 2341799
Intestinal pseudo-obstruction 58.56 33.86 14 9928 122 2348021
Liver injury 58.38 33.86 28 9914 2286 2345857
Fryns syndrome 58.06 33.86 9 9933 0 2348143
Epistaxis 58.05 33.86 47 9895 9732 2338411
Altered state of consciousness 58.01 33.86 33 9909 3827 2344316
Gouty tophus 57.64 33.86 11 9931 26 2348117
Gout 57.16 33.86 24 9918 1431 2346712
Intentional product misuse 57.16 33.86 46 9896 9443 2338700
Nodal rhythm 56.98 33.86 17 9925 365 2347778
Acute pulmonary oedema 56.98 33.86 23 9919 1240 2346903
Tetany 56.79 33.86 18 9924 476 2347667
Hyperparathyroidism 56.64 33.86 18 9924 480 2347663
Hypertonic bladder 56.46 33.86 17 9925 377 2347766
Ventricular extrasystoles 56.41 33.86 26 9916 1940 2346203
Pulmonary arterial hypertension 56.08 33.86 33 9909 4077 2344066
Intra-abdominal haematoma 55.72 33.86 16 9926 299 2347844
Congestive cardiomyopathy 55.70 33.86 21 9921 942 2347201
Blood lactate dehydrogenase increased 55.64 33.86 31 9911 3453 2344690
Dyspnoea exertional 55.53 33.86 37 9905 5683 2342460
Blood uric acid increased 55.52 33.86 19 9923 642 2347501
Restlessness 55.43 33.86 34 9908 4529 2343614
Respiratory acidosis 55.20 33.86 20 9922 801 2347342
White blood cell count increased 55.15 33.86 40 9902 7038 2341105
Haemorrhagic diathesis 55.15 33.86 18 9924 524 2347619
Haemodynamic instability 55.02 33.86 22 9920 1157 2346986
Back pain 54.68 33.86 79 9863 31580 2316563
Jaundice 54.37 33.86 36 9906 5472 2342671
Atrioventricular block 54.35 33.86 22 9920 1195 2346948
Cardiac failure chronic 54.27 33.86 17 9925 432 2347711
Leukopenia 54.27 33.86 46 9896 10150 2337993
Metabolic encephalopathy 54.22 33.86 18 9924 553 2347590
Respiratory tract infection 54.06 33.86 32 9910 3997 2344146
Acute respiratory failure 53.96 33.86 29 9913 3009 2345134
Hypophosphataemia 53.55 33.86 21 9921 1049 2347094
Limb hypoplasia congenital 53.54 33.86 10 9932 20 2348123
Subdural haematoma 53.11 33.86 26 9916 2220 2345923
Anal incontinence 52.62 33.86 24 9918 1748 2346395
Rectal haemorrhage 52.36 33.86 36 9906 5820 2342323
Dyspnoea at rest 51.91 33.86 16 9926 385 2347758
Gastrointestinal tract mucosal pigmentation 51.72 33.86 10 9932 26 2348117
Chills 51.65 33.86 54 9888 15498 2332645
Abnormal behaviour 51.61 33.86 33 9909 4727 2343416
Crepitations 51.51 33.86 18 9924 648 2347495
Intestinal obstruction 51.50 33.86 32 9910 4361 2343782
Hepatic function abnormal 51.08 33.86 36 9906 6056 2342087
Blood alkaline phosphatase increased 51.02 33.86 37 9905 6508 2341635
Renal disorder 50.87 33.86 32 9910 4456 2343687
Contusion 50.85 33.86 49 9893 12761 2335382
Chronic obstructive pulmonary disease 50.65 33.86 38 9904 7039 2341104
Left ventricular dysfunction 50.55 33.86 21 9921 1219 2346924
Product use in unapproved indication 50.53 33.86 46 9896 11154 2336989
Ejection fraction decreased 50.48 33.86 27 9915 2774 2345369
Oxygen saturation decreased 50.48 33.86 39 9903 7547 2340596
Pulmonary congestion 50.25 33.86 24 9918 1941 2346202
Cholecystitis 50.20 33.86 25 9917 2215 2345928
Glomerular filtration rate decreased 50.01 33.86 22 9920 1471 2346672
Left ventricular failure 49.99 33.86 18 9924 708 2347435
Blood phosphorus decreased 49.91 33.86 17 9925 566 2347577
Leukocytosis 49.54 33.86 29 9913 3547 2344596
Rash erythematous 49.38 33.86 35 9907 5941 2342202
Accidental overdose 49.28 33.86 30 9912 3942 2344201
Gamma-glutamyltransferase increased 49.28 33.86 34 9908 5528 2342615
Thrombocytosis 49.25 33.86 19 9923 908 2347235
Angioedema 49.09 33.86 40 9902 8356 2339787
Congenital diaphragmatic hernia 48.64 33.86 10 9932 39 2348104
Generalised oedema 48.54 33.86 25 9917 2378 2345765
Talipes 48.19 33.86 14 9928 273 2347870
Congenital oral malformation 48.18 33.86 9 9933 18 2348125
Lung disorder 48.16 33.86 35 9907 6177 2341966
Acute myocardial infarction 47.39 33.86 32 9910 5023 2343120
Haematocrit decreased 46.97 33.86 30 9912 4288 2343855
Haematuria 46.97 33.86 30 9912 4288 2343855
Supraventricular tachycardia 46.74 33.86 23 9919 1986 2346157
Pericardial effusion 46.48 33.86 29 9913 3980 2344163
Aortic valve incompetence 46.32 33.86 18 9924 877 2347266
Normochromic normocytic anaemia 46.13 33.86 17 9925 715 2347428
Congenital nail disorder 45.85 33.86 9 9933 26 2348117
Iron deficiency anaemia 45.78 33.86 23 9919 2076 2346067
Microtia 45.67 33.86 10 9932 56 2348087
Colitis microscopic 45.54 33.86 18 9924 918 2347225
Dry mouth 45.49 33.86 38 9904 8215 2339928
Gravitational oedema 45.42 33.86 12 9930 162 2347981
Sudden death 45.39 33.86 22 9920 1838 2346305
Hypothermia 45.28 33.86 23 9919 2125 2346018
Tracheo-oesophageal fistula 45.21 33.86 11 9931 104 2348039
Ventricular arrhythmia 45.14 33.86 16 9926 601 2347542
Neutropenia 45.07 33.86 59 9883 21489 2326654
Hyperhidrosis 44.98 33.86 50 9892 15372 2332771
Myoclonus 44.93 33.86 24 9918 2459 2345684
Joint swelling 44.77 33.86 52 9890 16767 2331376
Jugular vein distension 43.46 33.86 11 9931 124 2348019
Blood pressure systolic increased 43.43 33.86 23 9919 2316 2345827
Cor pulmonale 43.10 33.86 13 9929 290 2347853
Myopathy 43.00 33.86 20 9922 1523 2346620
Cardiomegaly 42.91 33.86 23 9919 2373 2345770
Gastroenteritis 42.88 33.86 25 9917 3035 2345108
Purpura senile 42.50 33.86 8 9934 17 2348126
Respiratory distress 42.28 33.86 30 9912 5099 2343044
Alveolitis 42.05 33.86 14 9928 434 2347709
Hypoaesthesia 41.73 33.86 55 9887 20160 2327983
Tachypnoea 41.62 33.86 22 9920 2207 2345936
Erythromelalgia 41.48 33.86 9 9933 48 2348095
Urosepsis 41.14 33.86 21 9921 1960 2346183
Basilar artery occlusion 41.05 33.86 8 9934 22 2348121
Off label use 40.76 33.86 114 9828 73484 2274659
Suicide attempt 40.76 33.86 41 9901 11241 2336902
Hepatitis fulminant 40.45 33.86 15 9927 642 2347501
Vascular purpura 40.38 33.86 12 9930 254 2347889
Mental status changes 40.00 33.86 30 9912 5552 2342591
Cardiac output decreased 39.79 33.86 11 9931 178 2347965
Intestinal ischaemia 39.55 33.86 17 9925 1074 2347069
Cardiomyopathy 39.51 33.86 23 9919 2784 2345359
Poisoning 39.41 33.86 23 9919 2797 2345346
Mobility decreased 39.37 33.86 36 9906 8774 2339369
Hypertriglyceridaemia 39.33 33.86 16 9926 880 2347263
Swelling 39.31 33.86 48 9894 16302 2331841
Oesophageal atresia 39.09 33.86 10 9932 118 2348025
Tenderness 38.87 33.86 20 9922 1898 2346245
Supraventricular extrasystoles 38.79 33.86 15 9927 721 2347422
Chest discomfort 38.63 33.86 45 9897 14550 2333593
Pulmonary hypoplasia 38.33 33.86 9 9933 72 2348071
Oligohydramnios 38.26 33.86 16 9926 944 2347199
Neck deformity 38.22 33.86 9 9933 73 2348070
Nephropathy toxic 38.16 33.86 17 9925 1171 2346972
Subcutaneous haematoma 37.94 33.86 12 9930 315 2347828
Bundle branch block left 37.88 33.86 16 9926 968 2347175
Tremor 37.77 33.86 53 9889 20608 2327535
Heart rate increased 37.65 33.86 39 9903 11066 2337077
Retroperitoneal haematoma 37.60 33.86 13 9929 453 2347690
Extrasystoles 37.34 33.86 16 9926 1003 2347140
Inflammation 37.16 33.86 30 9912 6183 2341960
Premature labour 37.11 33.86 20 9922 2086 2346057
Exercise tolerance decreased 36.98 33.86 14 9928 635 2347508
Skin turgor decreased 36.71 33.86 9 9933 88 2348055
Cerebral infarction 36.68 33.86 26 9916 4411 2343732
Pain in extremity 36.47 33.86 78 9864 42462 2305681
Patent ductus arteriosus 36.47 33.86 14 9928 660 2347483
Hypertrophic cardiomyopathy 36.40 33.86 11 9931 247 2347896
Diabetes mellitus inadequate control 36.30 33.86 19 9923 1868 2346275
Haemorrhage 36.05 33.86 38 9904 11001 2337142
Hypokalaemic syndrome 35.98 33.86 7 9935 19 2348124
Disseminated intravascular coagulation 35.76 33.86 23 9919 3327 2344816
Gouty arthritis 35.75 33.86 9 9933 99 2348044
Hypoalbuminaemia 35.56 33.86 17 9925 1377 2346766
Developmental hip dysplasia 35.23 33.86 10 9932 179 2347964
Feeling abnormal 35.21 33.86 55 9887 23526 2324617
Respiratory arrest 35.20 33.86 29 9913 6149 2341994
Milk-alkali syndrome 35.12 33.86 9 9933 107 2348036
Dizziness postural 35.03 33.86 15 9927 939 2347204
Atrioventricular block first degree 34.83 33.86 15 9927 952 2347191
Retrognathia 34.76 33.86 8 9934 58 2348085
Resting tremor 34.59 33.86 9 9933 114 2348029
Electrocardiogram ST segment abnormal 34.37 33.86 10 9932 196 2347947
Cellulitis 34.27 33.86 34 9908 9167 2338976
Aphasia 34.24 33.86 26 9916 4902 2343241
Diabetes mellitus 34.22 33.86 31 9911 7464 2340679
Bronchitis 34.17 33.86 41 9901 13673 2334470

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 5375.95 34.82 1695 7017 33249 1704820
Hypotension 2159.41 34.82 835 7877 28819 1709250
Dehydration 1664.77 34.82 603 8109 17055 1721014
Hyperkalaemia 1633.17 34.82 498 8214 8049 1730020
Hypokalaemia 1422.07 34.82 419 8293 5955 1732114
Hyponatraemia 1365.44 34.82 440 8272 8560 1729509
Syncope 1021.99 34.82 399 8313 13770 1724299
Cardiac failure 869.67 34.82 344 8368 12258 1725811
Fall 801.22 34.82 409 8303 26805 1711264
Dyspnoea 792.98 34.82 508 8204 51551 1686518
Renal failure 787.53 34.82 367 8345 19650 1718419
Blood creatinine increased 721.56 34.82 310 8402 13636 1724433
Orthostatic hypotension 673.93 34.82 205 8507 3226 1734843
Oedema peripheral 638.37 34.82 294 8418 15256 1722813
Renal impairment 611.18 34.82 266 8446 12048 1726021
Drug interaction 608.00 34.82 344 8368 27614 1710455
Dizziness 600.83 34.82 367 8345 33994 1704075
Bradycardia 520.56 34.82 227 8485 10307 1727762
Blood urea increased 455.54 34.82 165 8547 4546 1733523
Asthenia 439.44 34.82 303 8409 34367 1703702
Hypovolaemia 432.18 34.82 116 8596 1124 1736945
Atrial fibrillation 379.61 34.82 205 8507 14906 1723163
Presyncope 339.27 34.82 115 8597 2583 1735486
Diarrhoea 339.17 34.82 312 8400 53540 1684529
Completed suicide 335.26 34.82 194 8518 16118 1721951
Oedema 333.88 34.82 147 8565 6801 1731268
Confusional state 329.38 34.82 211 8501 21067 1717002
Lactic acidosis 321.21 34.82 131 8581 4998 1733071
Condition aggravated 313.20 34.82 204 8508 20946 1717123
Toxic epidermal necrolysis 297.83 34.82 101 8611 2270 1735799
Chronic kidney disease 297.01 34.82 118 8594 4199 1733870
Polyuria 255.59 34.82 78 8634 1232 1736837
Cardiac failure congestive 252.40 34.82 158 8554 15112 1722957
General physical health deterioration 245.57 34.82 147 8565 12971 1725098
Metabolic alkalosis 232.70 34.82 51 8661 183 1737886
Anuria 231.48 34.82 79 8633 1809 1736260
Hypertension 229.14 34.82 163 8549 19285 1718784
Ventricular tachycardia 224.05 34.82 93 8619 3705 1734364
Rhabdomyolysis 217.21 34.82 128 8584 10962 1727107
Hypomagnesaemia 211.95 34.82 76 8636 2022 1736047
Pemphigoid 209.78 34.82 65 8647 1082 1736987
Agranulocytosis 198.96 34.82 84 8628 3492 1734577
Toxicity to various agents 198.58 34.82 177 8535 28964 1709105
Loss of consciousness 194.56 34.82 133 8579 14742 1723327
Malaise 186.56 34.82 172 8540 29393 1708676
Left ventricular dysfunction 185.69 34.82 60 8652 1151 1736918
Hypocalcaemia 185.17 34.82 77 8635 3079 1734990
Blood pressure decreased 183.97 34.82 101 8611 7545 1730524
Cardiac failure chronic 181.10 34.82 51 8661 597 1737472
Respiratory failure 180.98 34.82 126 8586 14379 1723690
Metabolic acidosis 174.66 34.82 87 8625 5315 1732754
Drug ineffective 171.90 34.82 238 8474 63563 1674506
Anaemia 171.66 34.82 164 8548 29293 1708776
Electrocardiogram QT prolonged 160.87 34.82 83 8629 5462 1732607
Vomiting 159.46 34.82 178 8534 38137 1699932
Mitral valve incompetence 157.97 34.82 60 8652 1882 1736187
Thrombocytopenia 156.47 34.82 135 8577 21114 1716955
Pneumonia 156.42 34.82 193 8519 45989 1692080
Venous pressure jugular increased 151.38 34.82 31 8681 72 1737997
Long QT syndrome 150.52 34.82 38 8674 281 1737788
Sepsis 150.25 34.82 127 8585 19311 1718758
Cardiogenic shock 147.74 34.82 61 8651 2393 1735676
Eosinophilia 144.97 34.82 67 8645 3460 1734609
Hepatic encephalopathy 144.88 34.82 59 8653 2233 1735836
Chronic obstructive pulmonary disease 141.39 34.82 78 8634 5875 1732194
Nausea 140.67 34.82 193 8519 51003 1687066
Blood potassium increased 139.25 34.82 59 8653 2471 1735598
Weight increased 137.71 34.82 97 8615 11260 1726809
Medication error 137.57 34.82 71 8641 4672 1733397
Decreased appetite 137.23 34.82 132 8580 23739 1714330
International normalised ratio increased 137.20 34.82 86 8626 8213 1729856
Tubulointerstitial nephritis 136.77 34.82 61 8651 2897 1735172
Fatigue 135.84 34.82 189 8523 50592 1687477
Stevens-Johnson syndrome 135.57 34.82 63 8649 3294 1734775
Pyrexia 135.15 34.82 180 8532 46220 1691849
Multiple organ dysfunction syndrome 133.58 34.82 88 8624 9154 1728915
Drug reaction with eosinophilia and systemic symptoms 133.11 34.82 71 8641 4999 1733070
Haemoglobin decreased 132.59 34.82 112 8600 17002 1721067
Cardiac arrest 131.18 34.82 108 8604 15822 1722247
Ascites 129.39 34.82 72 8640 5514 1732555
Hypoglycaemia 128.43 34.82 83 8629 8355 1729714
Hypernatraemia 127.31 34.82 43 8669 951 1737118
Rash maculo-papular 126.68 34.82 62 8650 3641 1734428
Acute pulmonary oedema 126.32 34.82 45 8667 1172 1736897
Cardiac murmur 126.14 34.82 45 8667 1177 1736892
Pulmonary oedema 126.14 34.82 75 8637 6511 1731558
Urine output decreased 125.59 34.82 47 8665 1413 1736656
Cardiac failure acute 122.83 34.82 44 8668 1165 1736904
Overdose 122.64 34.82 106 8606 16595 1721474
Premature baby 118.13 34.82 55 8657 2887 1735182
Somnolence 114.39 34.82 102 8610 16637 1721432
Torsade de pointes 111.62 34.82 42 8670 1282 1736787
Hypophagia 109.09 34.82 55 8657 3442 1734627
Abdominal pain 107.09 34.82 110 8602 21380 1716689
Tricuspid valve incompetence 106.76 34.82 40 8672 1206 1736863
Dissociation 105.83 34.82 28 8684 254 1737815
Rales 105.65 34.82 37 8675 915 1737154
Sopor 104.60 34.82 45 8667 1956 1736113
Cholestasis 103.77 34.82 54 8658 3611 1734458
Arrhythmia 103.58 34.82 64 8648 5952 1732117
Dyspnoea exertional 100.09 34.82 55 8657 4106 1733963
Generalised oedema 100.05 34.82 42 8670 1717 1736352
Pruritus 100.01 34.82 110 8602 23112 1714957
Encephalopathy 99.31 34.82 56 8656 4396 1733673
Fluid retention 98.99 34.82 53 8659 3756 1734313
Blood potassium decreased 98.68 34.82 45 8667 2250 1735819
Hepatic function abnormal 96.48 34.82 65 8647 7009 1731060
Ejection fraction decreased 96.47 34.82 44 8668 2201 1735868
Left ventricular failure 96.46 34.82 32 8680 668 1737401
Blood lactic acid 94.31 34.82 17 8695 12 1738057
Toxic skin eruption 94.02 34.82 41 8671 1842 1736227
Oliguria 93.76 34.82 36 8676 1162 1736907
Glomerular filtration rate decreased 93.75 34.82 38 8674 1419 1736650
Melaena 93.70 34.82 57 8655 5153 1732916
Weight decreased 93.19 34.82 105 8607 22648 1715421
Dermatitis bullous 93.01 34.82 36 8676 1188 1736881
Foetal exposure during pregnancy 92.93 34.82 61 8651 6298 1731771
Pleural effusion 92.80 34.82 76 8636 11034 1727035
Pulmonary hypertension 91.05 34.82 45 8667 2697 1735372
Rash 90.07 34.82 135 8577 38558 1699511
Cardio-respiratory arrest 89.22 34.82 69 8643 9224 1728845
Hypovolaemic shock 88.31 34.82 32 8680 876 1737193
Depressed level of consciousness 86.15 34.82 59 8653 6533 1731536
Hyperuricaemia 85.89 34.82 32 8680 949 1737120
Low birth weight baby 85.29 34.82 31 8681 856 1737213
Hyperthermia 85.02 34.82 37 8675 1654 1736415
Pallor 84.55 34.82 46 8666 3365 1734704
Gout 84.10 34.82 42 8670 2574 1735495
C-reactive protein increased 82.46 34.82 55 8657 5830 1732239
Septic shock 81.77 34.82 62 8650 8047 1730022
Erythema 80.53 34.82 78 8634 14110 1723959
Tachypnoea 79.18 34.82 39 8673 2319 1735750
Tachycardia 78.47 34.82 73 8639 12555 1725514
Circulatory collapse 78.37 34.82 44 8668 3423 1734646
Foetal disorder 77.32 34.82 17 8695 62 1738007
Blood sodium decreased 77.05 34.82 38 8674 2266 1735803
Nephrocalcinosis 76.65 34.82 19 8693 129 1737940
Interstitial lung disease 76.11 34.82 64 8648 9632 1728437
Pseudoporphyria 75.68 34.82 17 8695 70 1737999
Blood creatine phosphokinase increased 74.81 34.82 61 8651 8795 1729274
Disorientation 73.95 34.82 50 8662 5419 1732650
Diastolic dysfunction 72.69 34.82 24 8688 493 1737576
Haemodialysis 72.49 34.82 38 8674 2578 1735491
Jaundice 71.60 34.82 51 8661 6011 1732058
Renal tubular necrosis 71.01 34.82 35 8677 2084 1735985
Neutropenia neonatal 68.21 34.82 14 8698 33 1738036
Orthopnoea 68.19 34.82 24 8688 602 1737467
Left ventricular hypertrophy 68.09 34.82 26 8686 826 1737243
Haematuria 67.94 34.82 54 8658 7506 1730563
Ventricular fibrillation 67.84 34.82 37 8675 2719 1735350
Hypoxia 67.75 34.82 49 8663 5914 1732155
Electrolyte imbalance 66.70 34.82 30 8682 1451 1736618
Fluid overload 66.07 34.82 33 8679 2022 1736047
Hyperhidrosis 65.91 34.82 66 8646 12422 1725647
Blood pressure systolic decreased 65.78 34.82 24 8688 670 1737399
Pancytopenia 65.48 34.82 63 8649 11294 1726775
Dermatitis exfoliative 65.19 34.82 30 8682 1531 1736538
Haematocrit decreased 64.88 34.82 42 8670 4231 1733838
Cough 64.32 34.82 80 8632 19117 1718952
Blood glucose increased 63.46 34.82 60 8652 10524 1727545
Left ventricular dilatation 63.26 34.82 14 8698 53 1738016
Hepatic enzyme increased 63.17 34.82 49 8663 6572 1731497
Hyperglycaemia 62.25 34.82 44 8668 5121 1732948
Vitamin B1 deficiency 62.10 34.82 13 8699 35 1738034
Lichenoid keratosis 61.93 34.82 20 8692 382 1737687
Pancreatitis acute 61.63 34.82 40 8672 4047 1734022
Blister 61.58 34.82 40 8672 4052 1734017
Incontinence 60.02 34.82 25 8687 1001 1737068
Eczema 59.42 34.82 32 8680 2292 1735777
Hepatic failure 59.19 34.82 45 8667 5858 1732211
Acrodermatitis enteropathica 58.99 34.82 10 8702 2 1738067
White blood cell count increased 58.89 34.82 49 8663 7263 1730806
Seizure 58.80 34.82 79 8633 20362 1717707
Eosinophil count increased 58.74 34.82 27 8685 1374 1736695
Purpura 58.54 34.82 29 8683 1745 1736324
Abnormal loss of weight 56.59 34.82 20 8692 508 1737561
Skin abrasion 56.45 34.82 23 8689 870 1737199
Prerenal failure 56.04 34.82 17 8695 262 1737807
Inappropriate antidiuretic hormone secretion 55.98 34.82 28 8684 1720 1736349
Thirst 55.72 34.82 25 8687 1202 1736867
Abdominal distension 55.70 34.82 45 8667 6399 1731670
Palpitations 55.57 34.82 46 8666 6768 1731301
Feeling abnormal 55.24 34.82 57 8655 11109 1726960
Jugular vein distension 54.92 34.82 14 8698 108 1737961
Alanine aminotransferase increased 54.22 34.82 59 8653 12219 1725850
Agitation 54.03 34.82 56 8656 10970 1727099
Drug abuse 53.97 34.82 62 8650 13627 1724442
Aspartate aminotransferase increased 53.38 34.82 55 8657 10701 1727368
Normochromic normocytic anaemia 51.77 34.82 20 8692 656 1737413
Brain natriuretic peptide increased 51.35 34.82 19 8693 552 1737517
Respiratory rate increased 51.33 34.82 24 8688 1270 1736799
Bundle branch block left 51.25 34.82 21 8691 806 1737263
Heart rate decreased 51.17 34.82 31 8681 2778 1735291
Cardiomegaly 51.06 34.82 29 8683 2305 1735764
Staring 51.04 34.82 17 8695 359 1737710
Coma 51.01 34.82 45 8667 7217 1730852
Blood lactate dehydrogenase increased 50.63 34.82 34 8678 3641 1734428
Drug hypersensitivity 50.55 34.82 63 8649 15072 1722997
Sinus bradycardia 50.49 34.82 27 8685 1906 1736163
Hypothermia 50.16 34.82 26 8686 1722 1736347
Inflammation 50.14 34.82 33 8679 3417 1734652
Liver disorder 50.07 34.82 40 8672 5596 1732473
Sudden death 49.87 34.82 31 8681 2909 1735160
Left ventricular enlargement 49.84 34.82 11 8701 41 1738028
Blood pressure increased 49.81 34.82 53 8659 10700 1727369
Peripheral swelling 49.33 34.82 46 8666 7925 1730144
Skin ulcer 48.82 34.82 30 8682 2758 1735311
Bundle branch block right 48.75 34.82 23 8689 1242 1736827
Blood bilirubin increased 48.73 34.82 41 8671 6169 1731900
Dizziness postural 47.34 34.82 20 8692 830 1737239
Altered state of consciousness 47.33 34.82 32 8680 3465 1734604
Hypersensitivity vasculitis 47.09 34.82 22 8690 1162 1736907
Atrioventricular block 46.99 34.82 23 8689 1348 1736721
Renal injury 46.91 34.82 22 8690 1172 1736897
Lower respiratory tract infection 46.85 34.82 33 8679 3818 1734251
Blood pressure diastolic decreased 46.32 34.82 19 8693 731 1737338
Platelet count decreased 46.19 34.82 63 8649 16460 1721609
Haematoma 46.13 34.82 33 8679 3912 1734157
Paraesthesia 45.75 34.82 50 8662 10401 1727668
Blood chloride increased 45.66 34.82 15 8697 303 1737766
Melanoderma 45.58 34.82 10 8702 36 1738033
Hypercalcaemia 45.52 34.82 25 8687 1861 1736208
Chest pain 45.52 34.82 69 8643 19845 1718224
Wernicke's encephalopathy 44.95 34.82 12 8700 113 1737956
Lung disorder 44.77 34.82 36 8676 5083 1732986
Accidental overdose 44.53 34.82 33 8679 4131 1733938
Therapy non-responder 44.35 34.82 39 8673 6227 1731842
Gait disturbance 44.34 34.82 54 8658 12616 1725453
Urinary incontinence 44.27 34.82 28 8684 2708 1735361
Right atrial enlargement 44.21 34.82 9 8703 20 1738049
Petit mal epilepsy 44.19 34.82 17 8695 551 1737518
Hypercalciuria 44.08 34.82 11 8701 77 1737992
Blood uric acid increased 44.04 34.82 20 8692 989 1737080
Rash vesicular 43.66 34.82 16 8696 452 1737617
Hepatitis 43.66 34.82 35 8677 4920 1733149
Red blood cell count decreased 43.48 34.82 31 8681 3655 1734414
Dermatitis exfoliative generalised 43.28 34.82 15 8697 359 1737710
Muscle spasms 43.07 34.82 51 8661 11570 1726499
Blood lactic acid increased 43.01 34.82 19 8693 880 1737189
Cardiac ablation 42.78 34.82 12 8700 138 1737931
Atrial enlargement 42.62 34.82 8 8704 9 1738060
Drug eruption 42.55 34.82 28 8684 2898 1735171
Respiratory distress 42.43 34.82 35 8677 5122 1732947
Acute respiratory failure 42.43 34.82 28 8684 2912 1735157
Azotaemia 42.37 34.82 18 8694 757 1737312
Leukocytosis 42.34 34.82 30 8682 3503 1734566
Rectal haemorrhage 42.27 34.82 36 8676 5506 1732563
Atrial flutter 42.13 34.82 24 8688 1918 1736151
Head injury 41.71 34.82 28 8684 2996 1735073
Mitral valve thickening 41.33 34.82 8 8704 12 1738057
Alkalosis hypochloraemic 41.33 34.82 8 8704 12 1738057
Heart rate increased 41.11 34.82 38 8674 6472 1731597
Pulmonary congestion 41.03 34.82 23 8689 1782 1736287
Necrotising oesophagitis 40.85 34.82 10 8702 64 1738005
Renal tubular disorder 40.27 34.82 18 8694 857 1737212
Shock 40.12 34.82 31 8681 4130 1733939
Hyponatraemic syndrome 39.88 34.82 9 8703 38 1738031
Hepatitis acute 39.85 34.82 20 8692 1237 1736832
Lethargy 39.78 34.82 39 8673 7145 1730924
Ventricular hyperkinesia 39.54 34.82 8 8704 17 1738052
Ventricular extrasystoles 39.53 34.82 23 8689 1913 1736156
Intentional overdose 39.45 34.82 40 8672 7630 1730439
Mental status changes 39.41 34.82 36 8676 6039 1732030
Bradyarrhythmia 39.16 34.82 14 8698 368 1737701
Product monitoring error 38.26 34.82 10 8702 86 1737983
Renal ischaemia 38.26 34.82 10 8702 86 1737983
Blood calcium decreased 38.13 34.82 20 8692 1357 1736712
Blood alkaline phosphatase increased 38.10 34.82 33 8679 5162 1732907
Left atrial enlargement 38.00 34.82 9 8703 49 1738020
Leukopenia 37.86 34.82 41 8671 8439 1729630
Hepatic cirrhosis 37.64 34.82 25 8687 2628 1735441
Nephrotic syndrome 37.60 34.82 20 8692 1396 1736673
Choking 37.37 34.82 18 8694 1018 1737051
Sphincter of Oddi dysfunction 36.86 34.82 8 8704 27 1738042
Gamma-glutamyltransferase increased 36.61 34.82 32 8680 5066 1733003
Cerebral haemorrhage 36.49 34.82 35 8677 6242 1731827
Urinary tract discomfort 36.36 34.82 7 8705 10 1738059
Blood sodium increased 36.36 34.82 14 8698 455 1737614
Cardioactive drug level increased 36.32 34.82 12 8700 247 1737822
Diabetic metabolic decompensation 36.29 34.82 11 8701 169 1737900
Blood creatine increased 36.07 34.82 16 8696 748 1737321
Proteinuria 36.06 34.82 25 8687 2819 1735250
Ischaemic hepatitis 35.87 34.82 12 8700 257 1737812
Renal artery thrombosis 35.82 34.82 9 8703 65 1738004
Constipation 35.72 34.82 53 8659 14947 1723122
Skin exfoliation 35.69 34.82 30 8682 4505 1733564
Gastroenteritis 35.40 34.82 22 8690 2062 1736007
Hypochromasia 35.22 34.82 8 8704 35 1738034
Urinary retention 35.05 34.82 32 8680 5363 1732706
Angina pectoris 35.04 34.82 31 8681 4987 1733082
Rash erythematous 34.91 34.82 28 8684 3937 1734132
Product prescribing error 34.89 34.82 23 8689 2387 1735682

Pharmacologic Action:

SourceCodeDescription
ATC C03CA01 CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Sulfonamides, plain
ATC C03CB01 CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Sulfonamides and potassium in combination
ATC C03EB01 CARDIOVASCULAR SYSTEM
DIURETICS
DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
High-ceiling diuretics and potassium-sparing agents
FDA PE N0000175366 Increased Diuresis at Loop of Henle
CHEBI has role CHEBI:77608 loop diuretic
MeSH PA D004232 Diuretics
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D045283 Natriuretic Agents
MeSH PA D049994 Sodium Potassium Chloride Symporter Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Acute pulmonary edema indication 40541001
Decompensated cardiac failure indication 195111005
Edema indication 267038008
Pulmonary Edema due to Chronic Heart Failure indication
Edema due to Hepatic Cirrhosis indication
Peripheral Edema due to Chronic Heart Failure indication
Hypercalcemia off-label use 66931009 DOID:12678
Prevention of Oliguria off-label use
Metabolic alkalosis contraindication 1388004
Anuria contraindication 2472002 DOID:2983
Hypocalcemia contraindication 5291005
Hypochloremia contraindication 10399008
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Diabetes mellitus contraindication 73211009 DOID:9351
Pancreatitis contraindication 75694006 DOID:4989
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Hearing disorder contraindication 128540005
Hypomagnesemia contraindication 190855004
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Azotemia contraindication 445009001

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.69 acidic
pKa2 10.59 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Solute carrier family 12 member 1 Transporter INHIBITOR IC50 6.20 WOMBAT-PK CHEMBL
Carbonic anhydrase 2 Enzyme Ki 7.19 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 6.58 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 6.25 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme IC50 5.42 CHEMBL
G-protein coupled receptor 35 GPCR Ki 5.49 CHEMBL
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 6.30 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 7.28 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 6.29 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 6.38 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 7.21 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 6.49 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 6.61 CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-1 Transporter WOMBAT-PK
Solute carrier family 12 member 2 Transporter INHIBITOR IC50 5.13 IUPHAR
Carbonic anhydrase 13 Enzyme Ki 6.26 CHEMBL
Holo-[acyl-carrieir-protein] synthase Unclassified IC50 4.90 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme IC50 5.42 CHEMBL

External reference:

IDSource
D005665 MESH_DESCRIPTOR_UI
4017830 VUID
N0000146188 NUI
C0016860 UMLSCUI
D00331 KEGG_DRUG
7LXU5N7ZO5 UNII
1584 INN_ID
81609008 SNOMEDCT_US
3962 MMSL
4603 RXNORM
387475002 SNOMEDCT_US
4769 MMSL
d00070 MMSL
4017830 VANDF
002307 NDDF
CHEMBL35 ChEMBL_ID
DB00695 DRUGBANK_ID
FUN PDB_CHEM_ID
CHEBI:47426 CHEBI
3440 PUBCHEM_CID
CHEMBL1788133 ChEMBL_ID
4839 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-3294 SOLUTION 10 mg ORAL ANDA 11 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-3298 SOLUTION 40 mg ORAL ANDA 11 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4297 TABLET 20 mg ORAL NDA 11 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4299 TABLET 40 mg ORAL NDA 11 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-4301 TABLET 80 mg ORAL ANDA 11 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8297 TABLET 20 mg ORAL NDA 11 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8299 TABLET 40 mg ORAL NDA 11 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-8301 TABLET 80 mg ORAL ANDA 11 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0208 TABLET 20 mg ORAL NDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0216 TABLET 40 mg ORAL NDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0232 TABLET 80 mg ORAL ANDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0409-1639 INJECTION, SOLUTION 10 mg INTRAMUSCULAR ANDA 12 sections
FUROSEMIDE HUMAN PRESCRIPTION DRUG LABEL 1 0409-6102 INJECTION, SOLUTION 10 mg INTRAMUSCULAR NDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0409-9631 INJECTION, SOLUTION 10 mg INTRAMUSCULAR ANDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-0446 TABLET 40 mg ORAL NDA 11 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-1569 TABLET 20 mg ORAL NDA 11 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-1571 TABLET 80 mg ORAL NDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7937 TABLET 20 mg ORAL NDA 12 sections
Fuosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7938 TABLET 40 mg ORAL NDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7957 TABLET 80 mg ORAL ANDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0781-1446 TABLET 80 mg ORAL NDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0781-1818 TABLET 20 mg ORAL NDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 0781-1966 TABLET 40 mg ORAL NDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 10544-131 TABLET 20 mg ORAL ANDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 10544-584 TABLET 40 mg ORAL ANDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 12634-416 TABLET 20 mg ORAL ANDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 12634-533 TABLET 40 mg ORAL ANDA 12 sections
FUROSEMIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-284 TABLET 40 mg ORAL ANDA 12 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 17856-3298 SOLUTION 40 mg ORAL ANDA 11 sections
Furosemide HUMAN PRESCRIPTION DRUG LABEL 1 17856-3755 SOLUTION 40 mg ORAL ANDA 11 sections