torsemide ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diuretics, furosemide derivatives 2708 56211-40-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • torasemide
  • torsemide
  • toradiur
A pyridine and sulfonamide derivative that acts as a sodium-potassium chloride symporter inhibitor (loop diuretic). It is used for the treatment of EDEMA associated with CONGESTIVE HEART FAILURE; CHRONIC RENAL INSUFFICIENCY; and LIVER DISEASES. It is also used for the management of HYPERTENSION.
  • Molecular weight: 348.42
  • Formula: C16H20N4O3S
  • CLOGP: 3.21
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 100.19
  • ALOGS: -3.77
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
15 mg O
15 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.16 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 20 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 9.56 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 91 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.21 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.53 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 23, 1993 FDA MEDA PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 1574.70 11.46 1314 58022 141120 50404668
Product prescribing error 694.46 11.46 383 58953 20578 50525210
Product monitoring error 518.58 11.46 173 59163 2591 50543197
Haematochezia 478.60 11.46 387 58949 39495 50506293
Drug ineffective 467.84 11.46 190 59146 819143 49726645
Cardiac failure 406.69 11.46 473 58863 75567 50470221
Dyspnoea 329.63 11.46 1389 57947 546219 49999569
Oedema peripheral 297.86 11.46 605 58731 157356 50388432
Anaemia 257.32 11.46 763 58573 251693 50294095
Renal impairment 243.49 11.46 367 58969 75294 50470494
Acute kidney injury 226.34 11.46 683 58653 227375 50318413
Dehydration 221.49 11.46 526 58810 151923 50393865
Systemic infection 218.61 11.46 87 59249 2196 50543592
Atrial fibrillation 217.41 11.46 411 58925 101334 50444454
Syncope 208.93 11.46 407 58929 102595 50443193
Labelled drug-drug interaction medication error 201.00 11.46 135 59201 10342 50535446
Bradycardia 199.46 11.46 307 59029 64119 50481669
Electrolyte imbalance 177.59 11.46 153 59183 17016 50528772
Rash 175.96 11.46 153 59183 437318 50108470
Hypotension 169.39 11.46 633 58703 234836 50310952
Joint swelling 167.25 11.46 41 59295 245245 50300543
Pulmonary arterial hypertension 164.89 11.46 158 59178 20161 50525627
Fall 164.06 11.46 801 58535 334131 50211657
Drug interaction 160.85 11.46 557 58779 199064 50346724
Haematemesis 160.76 11.46 180 59156 27545 50518243
Drug hypersensitivity 157.98 11.46 49 59287 250961 50294827
Arrhythmia 150.64 11.46 190 59146 32942 50512846
Drug intolerance 150.57 11.46 36 59300 219068 50326720
Arthropathy 140.57 11.46 12 59324 157894 50387894
Treatment failure 139.22 11.46 5 59331 137632 50408156
Fluid retention 137.00 11.46 227 59109 50422 50495366
Off label use 135.98 11.46 217 59119 474209 50071579
Infusion related reaction 128.65 11.46 22 59314 169535 50376253
Synovitis 127.04 11.46 4 59332 123861 50421927
Pallor 124.97 11.46 145 59191 23054 50522734
Systemic lupus erythematosus 124.30 11.46 11 59325 140611 50405177
Therapeutic product effect decreased 119.29 11.46 11 59325 136039 50409749
Rheumatoid arthritis 117.95 11.46 45 59291 202505 50343283
Product administration error 112.66 11.46 127 59209 19572 50526216
Hypersensitivity 112.32 11.46 56 59280 215105 50330683
Therapeutic drug monitoring analysis not performed 112.14 11.46 39 59297 666 50545122
Orthostatic intolerance 110.39 11.46 42 59294 936 50544852
Alopecia 107.99 11.46 78 59258 244969 50300819
Pain 107.51 11.46 336 59000 578567 49967221
Dizziness 107.45 11.46 734 58602 345635 50200153
Hyperkalaemia 107.25 11.46 198 59138 47891 50497897
Dyspnoea exertional 106.88 11.46 205 59131 51028 50494760
Hypervolaemia 103.06 11.46 138 59198 25361 50520427
Blood creatinine increased 101.04 11.46 254 59082 75906 50469882
Right ventricular failure 100.47 11.46 108 59228 15785 50530003
Angina pectoris 100.19 11.46 138 59198 26050 50519738
Hypokalaemia 98.02 11.46 275 59061 87717 50458071
Hyponatraemia 96.07 11.46 289 59047 95850 50449938
Lower respiratory tract infection 94.41 11.46 4 59332 95197 50450591
Discomfort 91.77 11.46 10 59326 108370 50437418
Completed suicide 89.89 11.46 22 59314 131867 50413921
Glomerular filtration rate decreased 87.77 11.46 87 59249 11565 50534223
Renal failure 86.98 11.46 299 59037 106334 50439454
Cardiac failure chronic 85.85 11.46 53 59283 3510 50542278
Pulmonary hypertension 84.01 11.46 145 59191 33272 50512516
Anuria 79.27 11.46 81 59255 11163 50534625
Abdominal discomfort 78.13 11.46 94 59242 231547 50314241
Gastrointestinal haemorrhage 77.61 11.46 225 59111 73096 50472692
Arthralgia 77.54 11.46 260 59076 438442 50107346
Melaena 73.41 11.46 121 59215 26743 50519045
Maternal exposure during pregnancy 72.79 11.46 49 59287 159729 50386059
Hyperglycaemia 71.45 11.46 142 59194 36263 50509525
Aortic valve stenosis 71.03 11.46 44 59292 2931 50542857
Swelling 70.44 11.46 79 59257 200793 50344995
Sinusitis 69.13 11.46 59 59277 170499 50375289
Musculoskeletal stiffness 67.66 11.46 33 59303 128448 50417340
Injection site pain 67.41 11.46 23 59313 111001 50434787
Blood loss anaemia 67.36 11.46 64 59272 8075 50537713
Pancreatic steatosis 64.00 11.46 28 59308 901 50544887
Product use issue 63.95 11.46 49 59287 149426 50396362
Lactic acidosis 62.94 11.46 128 59208 33227 50512561
Oedema 62.71 11.46 203 59133 69978 50475810
Pericarditis 60.10 11.46 10 59326 78679 50467109
Atrial flutter 57.95 11.46 61 59275 8702 50537086
Mitral valve incompetence 57.90 11.46 86 59250 17385 50528403
Cardiogenic shock 56.38 11.46 80 59256 15519 50530269
Tachyarrhythmia 55.99 11.46 43 59293 4062 50541726
Haematoma 55.11 11.46 115 59221 30395 50515393
Tricuspid valve incompetence 54.51 11.46 71 59265 12699 50533089
Gastroenteritis clostridial 52.36 11.46 21 59315 541 50545247
Cardiac failure congestive 51.70 11.46 216 59120 84166 50461622
Nasopharyngitis 51.59 11.46 92 59244 192835 50352953
Pleural effusion 51.08 11.46 210 59126 81244 50464544
Medication error 50.58 11.46 123 59213 35981 50509807
Exposure during pregnancy 50.08 11.46 41 59295 120974 50424814
Therapeutic product effect incomplete 48.94 11.46 23 59313 91492 50454296
Limb reduction defect 48.71 11.46 18 59318 369 50545419
Renal function test abnormal 48.24 11.46 34 59302 2815 50542973
Tachycardia 48.15 11.46 238 59098 99525 50446263
N-terminal prohormone brain natriuretic peptide increased 47.83 11.46 28 59308 1682 50544106
Disorientation 47.71 11.46 119 59217 35365 50510423
Arterial haemorrhage 47.57 11.46 27 59309 1530 50544258
Urticaria 47.56 11.46 49 59287 129512 50416276
Injection site reaction 46.77 11.46 3 59333 50029 50495759
Lymphatic fistula 46.52 11.46 21 59315 729 50545059
Femoral hernia incarcerated 46.22 11.46 21 59315 740 50545048
Chronic kidney disease 45.93 11.46 126 59210 39645 50506143
Irritable bowel syndrome 45.49 11.46 4 59332 51437 50494351
Hepatic enzyme increased 43.93 11.46 58 59278 137322 50408466
Blood urea increased 43.89 11.46 90 59246 23495 50522293
Coagulation test abnormal 42.16 11.46 19 59317 657 50545131
Back pain 41.84 11.46 126 59210 219904 50325884
Peripheral arterial occlusive disease 41.69 11.46 34 59302 3503 50542285
Tachypnoea 41.64 11.46 67 59269 14510 50531278
Hypoglycaemia 40.85 11.46 147 59189 53434 50492354
Contraindicated product administered 40.75 11.46 70 59266 148888 50396900
Retrograde amnesia 40.53 11.46 16 59320 395 50545393
Hyperthyroidism 40.44 11.46 60 59276 12115 50533673
Cardiac failure acute 40.19 11.46 49 59287 8201 50537587
Rhonchi 40.15 11.46 28 59308 2279 50543509
Injection site erythema 39.81 11.46 19 59317 74917 50470871
Haemoglobin decreased 39.50 11.46 270 59066 126946 50418842
Malaise 39.11 11.46 232 59104 335300 50210488
Gastrointestinal disorder 39.08 11.46 32 59304 94424 50451364
Peripheral circulatory failure 38.92 11.46 17 59319 545 50545243
Helicobacter infection 38.66 11.46 6 59330 49696 50496092
Arthritis 37.62 11.46 28 59308 86693 50459095
Stomatitis 37.56 11.46 38 59298 101306 50444482
Eructation 37.49 11.46 44 59292 7077 50538711
Diverticulum intestinal 36.93 11.46 40 59296 5893 50539895
Vascular resistance pulmonary decreased 36.42 11.46 10 59326 73 50545715
Wound infection pseudomonas 36.02 11.46 21 59315 1252 50544536
Left-to-right cardiac shunt 35.81 11.46 11 59325 124 50545664
Limb hypoplasia congenital 35.70 11.46 12 59324 184 50545604
Circulatory collapse 35.67 11.46 75 59261 19925 50525863
Internal haemorrhage 35.17 11.46 34 59302 4383 50541405
Polyneuropathy 34.98 11.46 56 59280 12075 50533713
Waist circumference increased 34.76 11.46 17 59319 709 50545079
Insomnia 34.05 11.46 99 59237 174766 50371022
Cholestatic liver injury 33.94 11.46 24 59312 1997 50543791
Coronavirus test positive 33.80 11.46 16 59320 620 50545168
Flatulence 33.68 11.46 93 59243 29365 50516423
Atrioventricular block complete 33.58 11.46 42 59294 7213 50538575
Seroma 33.58 11.46 23 59313 1818 50543970
Electrocardiogram abnormal 33.58 11.46 43 59293 7562 50538226
Haematuria 33.49 11.46 85 59251 25528 50520260
Blood potassium increased 33.42 11.46 65 59271 16333 50529455
Intentional product use issue 33.15 11.46 25 59311 76893 50468895
Product use in unapproved indication 32.99 11.46 53 59283 115766 50430022
Anxiety 32.83 11.46 103 59233 177503 50368285
Faecaloma 32.66 11.46 41 59295 7067 50538721
Left ventricular failure 32.55 11.46 34 59302 4807 50540981
Transfusion 32.43 11.46 56 59280 12849 50532939
Gamma-glutamyltransferase increased 32.38 11.46 92 59244 29531 50516257
Exercise tolerance decreased 32.35 11.46 34 59302 4840 50540948
Haemarthrosis 32.28 11.46 27 59309 2881 50542907
Crush syndrome 32.07 11.46 10 59326 119 50545669
Drug abuse 32.05 11.46 15 59321 59831 50485957
Congenital oral malformation 31.84 11.46 11 59325 184 50545604
Paraesthesia 31.53 11.46 58 59278 120185 50425603
Loss of personal independence in daily activities 31.19 11.46 22 59314 70028 50475760
Accidental overdose 31.13 11.46 70 59266 19463 50526325
Hepatic cyst 31.00 11.46 32 59304 4461 50541327
Pruritus 30.98 11.46 200 59136 283368 50262420
Stasis dermatitis 30.93 11.46 15 59321 614 50545174
Thirst 30.49 11.46 49 59287 10601 50535187
Toxicity to various agents 30.33 11.46 137 59199 212362 50333426
Erysipelas 30.18 11.46 38 59298 6570 50539218
Fracture 29.87 11.46 63 59273 16770 50529018
Psoriatic arthropathy 29.85 11.46 9 59327 47023 50498765
Blood uric acid increased 29.56 11.46 29 59307 3805 50541983
Blister 29.46 11.46 34 59302 85384 50460404
Tooth erosion 29.16 11.46 13 59323 438 50545350
Depression 29.14 11.46 98 59238 165325 50380463
Device stimulation issue 28.95 11.46 8 59328 60 50545728
Ascites 28.71 11.46 100 59236 35761 50510027
Anaphylactic reaction 28.26 11.46 14 59322 54041 50491747
Migraine 28.15 11.46 28 59308 75252 50470536
Respiratory failure 27.98 11.46 193 59143 90988 50454800
Haemorrhagic erosive gastritis 27.88 11.46 11 59325 271 50545517
Urosepsis 27.58 11.46 58 59278 15407 50530381
Injection site bruising 27.35 11.46 5 59331 36763 50509025
Hypertensive emergency 27.27 11.46 19 59317 1544 50544244
N-terminal prohormone brain natriuretic peptide abnormal 27.12 11.46 7 59329 39 50545749
Injection site pruritus 27.01 11.46 7 59329 40404 50505384
Pulmonary congestion 26.98 11.46 57 59279 15190 50530598
Oropharyngeal pain 26.80 11.46 31 59305 77770 50468018
Administration site discomfort 26.65 11.46 8 59328 83 50545705
Painful respiration 26.26 11.46 22 59314 2353 50543435
Biopsy skin abnormal 25.98 11.46 8 59328 91 50545697
Aplastic anaemia 25.64 11.46 38 59298 7665 50538123
Escherichia infection 25.58 11.46 46 59290 10895 50534893
Psoriasis 25.42 11.46 26 59310 68974 50476814
Thrombin time prolonged 25.15 11.46 8 59328 102 50545686
Product used for unknown indication 25.11 11.46 11 59325 355 50545433
Neuropathy peripheral 25.07 11.46 47 59289 96710 50449078
Cardioversion 24.99 11.46 16 59320 1129 50544659
Cleft palate 24.93 11.46 15 59321 948 50544840
Febrile neutropenia 24.82 11.46 48 59288 97619 50448169
Hypoaesthesia 24.80 11.46 72 59264 127185 50418603
Psychomotor retardation 24.78 11.46 25 59311 3393 50542395
Antineutrophil cytoplasmic antibody positive 24.57 11.46 12 59324 499 50545289
Prothrombin time prolonged 24.40 11.46 40 59296 8798 50536990
Headache 24.31 11.46 433 58903 506102 50039686
Hypertensive crisis 24.24 11.46 50 59286 13104 50532684
Glycosylated haemoglobin increased 24.04 11.46 44 59292 10562 50535226
Dementia 24.02 11.46 56 59280 15941 50529847
Upper gastrointestinal haemorrhage 23.93 11.46 56 59280 15979 50529809
Blood cholesterol increased 23.72 11.46 18 59318 55197 50490591
Bicytopenia 23.64 11.46 19 59317 1917 50543871
Restlessness 23.55 11.46 74 59262 25099 50520689
Abdominal pain 23.38 11.46 398 58938 235830 50309958
Sudden cardiac death 23.33 11.46 19 59317 1953 50543835
Mobility decreased 23.32 11.46 36 59300 79912 50465876
Bundle branch block right 23.29 11.46 28 59308 4617 50541171
Injection site swelling 23.11 11.46 10 59326 41763 50504025
Cerebral haemorrhage 23.03 11.46 77 59259 26975 50518813
Lower gastrointestinal haemorrhage 22.99 11.46 34 59302 6845 50538943
Joint stiffness 22.81 11.46 4 59332 30304 50515484
Gout 22.81 11.46 45 59291 11425 50534363
Fracture blisters 22.78 11.46 7 59329 79 50545709
Pelvic venous thrombosis 22.77 11.46 16 59320 1318 50544470
Hypothermia 22.53 11.46 46 59290 11970 50533818
Adverse drug reaction 22.47 11.46 19 59317 55203 50490585
Condition aggravated 22.39 11.46 480 58856 296578 50249210
Therapeutic drug monitoring analysis incorrectly performed 22.36 11.46 8 59328 149 50545639
Pneumothorax traumatic 22.07 11.46 8 59328 155 50545633
Pregnancy 22.05 11.46 4 59332 29573 50516215
Inflammatory marker increased 22.01 11.46 30 59306 5604 50540184
Thirst decreased 21.98 11.46 9 59327 245 50545543
Acute respiratory failure 21.96 11.46 79 59257 28703 50517085
Pericardial effusion 21.93 11.46 73 59263 25516 50520272
Helplessness 21.71 11.46 9 59327 253 50545535
Feeling abnormal 21.64 11.46 75 59261 125417 50420371
Pulpitis dental 21.63 11.46 13 59323 820 50544968
Dysuria 21.54 11.46 78 59258 28426 50517362
Aortic arteriosclerosis 21.54 11.46 29 59307 5353 50540435
Coma 21.44 11.46 21 59315 56858 50488930
Pulmonary vein occlusion 21.03 11.46 7 59329 104 50545684
Therapeutic response decreased 20.80 11.46 15 59321 47216 50498572
Cardiovascular disorder 20.77 11.46 41 59295 10413 50535375
Ear pain 20.71 11.46 4 59332 28279 50517509
Language disorder 20.68 11.46 17 59319 1771 50544017
Coronary artery disease 20.51 11.46 79 59257 29647 50516141
Retrognathia 20.51 11.46 10 59326 414 50545374
Abdominal distension 20.43 11.46 151 59185 72752 50473036
Abdominal pain lower 20.39 11.46 64 59272 21692 50524096
Pain in extremity 20.38 11.46 213 59123 272652 50273136
No adverse event 20.29 11.46 7 59329 33571 50512217
Suicidal ideation 20.25 11.46 21 59315 55364 50490424
Fibromyalgia 20.18 11.46 14 59322 44964 50500824
Urinary retention 20.08 11.46 72 59264 26118 50519670
Sensorimotor disorder 20.08 11.46 10 59326 434 50545354
Dyspnoea at rest 19.98 11.46 23 59313 3624 50542164
Osteoarthritis 19.90 11.46 31 59305 68575 50477213
Spinal pain 19.83 11.46 41 59295 10762 50535026
Dysmorphism 19.78 11.46 18 59318 2149 50543639
Talipes 19.70 11.46 15 59321 1399 50544389
Catheterisation cardiac 19.68 11.46 24 59312 4016 50541772
Antidiuretic hormone abnormality 19.66 11.46 5 59331 26 50545762
Epistaxis 19.39 11.46 135 59201 63819 50481969
Femoral artery dissection 19.06 11.46 5 59331 30 50545758
Pulmonary oedema 18.99 11.46 110 59226 48828 50496960
Orthopnoea 18.84 11.46 28 59308 5661 50540127
Necrotising fasciitis 18.79 11.46 19 59317 2585 50543203
Multiple sclerosis relapse 18.46 11.46 14 59322 42950 50502838
Infection 18.35 11.46 123 59213 172831 50372957
Herbal interaction 18.22 11.46 6 59330 86 50545702
Hyperparathyroidism secondary 18.10 11.46 14 59322 1336 50544452
International normalised ratio increased 18.07 11.46 99 59237 43053 50502735
Contusion 18.05 11.46 69 59267 112114 50433674
Post procedural haematuria 18.04 11.46 5 59331 38 50545750
Bradyarrhythmia 17.85 11.46 16 59320 1874 50543914
Lethargy 17.78 11.46 19 59317 49413 50496375
Depressed level of consciousness 17.76 11.46 113 59223 51840 50493948
Knee arthroplasty 17.68 11.46 10 59326 35836 50509952
Haemoptysis 17.68 11.46 68 59268 25505 50520283
Ill-defined disorder 17.53 11.46 23 59313 54631 50491157
Toxoplasmosis 17.50 11.46 14 59322 1403 50544385
Congenital coronary artery malformation 17.50 11.46 6 59330 98 50545690
Injury 17.38 11.46 19 59317 48906 50496882
Generalised oedema 17.36 11.46 45 59291 13686 50532102
Sinoatrial block 17.34 11.46 11 59325 764 50545024
Chest wall haematoma 17.32 11.46 7 59329 184 50545604
Serotonin syndrome 17.06 11.46 4 59332 24709 50521079
Irritability 17.05 11.46 6 59330 28420 50517368
Herpes zoster 16.95 11.46 36 59300 70750 50475038
Stress 16.89 11.46 23 59313 53770 50492018
Wound dehiscence 16.83 11.46 23 59313 4307 50541481
Developmental hip dysplasia 16.47 11.46 13 59323 1278 50544510
Presyncope 16.44 11.46 64 59272 24134 50521654
Concomitant disease aggravated 16.40 11.46 32 59304 8059 50537729
Red blood cell sedimentation rate increased 16.33 11.46 7 59329 29409 50516379
Cerebral artery occlusion 16.29 11.46 11 59325 849 50544939
Brain natriuretic peptide abnormal 16.28 11.46 8 59328 337 50545451
Musculoskeletal pain 16.15 11.46 142 59194 72035 50473753
Brain natriuretic peptide increased 16.04 11.46 23 59313 4504 50541284
Left ventricular dysfunction 16.02 11.46 37 59299 10469 50535319
Palpitations 15.81 11.46 175 59161 94331 50451457
Influenza 15.78 11.46 53 59283 89485 50456303
Dry eye 15.76 11.46 9 59327 32086 50513702
Red cell distribution width abnormal 15.76 11.46 6 59330 134 50545654
Hip arthroplasty 15.72 11.46 8 59328 30421 50515367
White blood cell count decreased 15.60 11.46 77 59259 116645 50429143
Multiple drug therapy 15.59 11.46 15 59321 1922 50543866
Parkinsonism 15.57 11.46 33 59303 8814 50536974
Chronic respiratory failure 15.56 11.46 14 59322 1648 50544140
Glomerular filtration rate abnormal 15.51 11.46 9 59327 532 50545256
Ecthyma 15.45 11.46 7 59329 245 50545543
Aggression 15.43 11.46 3 59333 21113 50524675
HCoV-HKU1 infection 15.39 11.46 4 59332 23 50545765
Upper respiratory tract infection 15.37 11.46 34 59302 65864 50479924
Vascular encephalopathy 15.35 11.46 8 59328 382 50545406
Cerebral ischaemia 15.32 11.46 26 59310 5882 50539906
Atrial septal defect 15.26 11.46 27 59309 6314 50539474
Throat tightness 15.15 11.46 3 59333 20844 50524944
Neutrophil count decreased 15.14 11.46 19 59317 46007 50499781
Ventricular assist device insertion 15.10 11.46 4 59332 25 50545763
Cardiorenal syndrome 14.94 11.46 9 59327 570 50545218
Blood cholesterol decreased 14.88 11.46 10 59326 766 50545022
Influenza like illness 14.80 11.46 28 59308 57431 50488357
Blood pressure systolic increased 14.66 11.46 12 59324 35437 50510351
Low density lipoprotein abnormal 14.59 11.46 6 59330 165 50545623
Decreased appetite 14.58 11.46 323 59013 200600 50345188
Periodontitis 14.58 11.46 18 59318 3051 50542737
Cerebral infarction 14.57 11.46 57 59279 21547 50524241
Aplasia 14.44 11.46 20 59316 3793 50541995
Constipation 14.26 11.46 301 59035 185407 50360381
Iron deficiency 14.16 11.46 25 59311 5837 50539951
Hyperphosphataemia 14.14 11.46 14 59322 1857 50543931
Cardio-respiratory arrest 14.11 11.46 26 59310 53866 50491922
Nephrolithiasis 14.04 11.46 12 59324 34681 50511107
Sleep disorder 13.82 11.46 29 59307 57254 50488534
Drug ineffective for unapproved indication 13.63 11.46 4 59332 21277 50524511
Hypertensive heart disease 13.60 11.46 15 59321 2255 50543533
Cardiac pacemaker insertion 13.59 11.46 19 59317 3634 50542154
Hepatic failure 13.47 11.46 74 59262 32209 50513579
Phrenic nerve paralysis 13.46 11.46 5 59331 104 50545684
Cardiac murmur functional 13.46 11.46 4 59332 40 50545748
Dyskinesia 13.42 11.46 8 59328 27853 50517935
Disturbance in attention 13.36 11.46 72 59264 31114 50514674
Diastolic dysfunction 13.31 11.46 23 59313 5279 50540509
Gamma-glutamyltransferase abnormal 13.30 11.46 6 59330 208 50545580
Drug resistance 13.26 11.46 3 59333 18986 50526802
Cardiomegaly 13.23 11.46 45 59291 15900 50529888
Febrile infection 13.16 11.46 11 59325 1173 50544615
Concomitant disease progression 13.10 11.46 14 59322 2031 50543757
Periorbital haematoma 13.07 11.46 9 59327 718 50545070
Lymphadenopathy 13.06 11.46 12 59324 33487 50512301
Polyuria 13.04 11.46 27 59309 7094 50538694
Lividity 12.93 11.46 6 59330 222 50545566
Alcoholic liver disease 12.83 11.46 5 59331 119 50545669
Alanine aminotransferase decreased 12.65 11.46 8 59328 553 50545235
Catheter site haemorrhage 12.58 11.46 16 59320 2794 50542994
Fungal infection 12.57 11.46 10 59326 29955 50515833
Right aortic arch 12.55 11.46 6 59330 238 50545550
Neutropenia 12.51 11.46 112 59224 147853 50397935
Asthma 12.48 11.46 58 59278 89279 50456509
Reactive gastropathy 12.44 11.46 7 59329 390 50545398
Atrioventricular block 12.38 11.46 25 59311 6453 50539335
Amnesia 12.35 11.46 19 59317 42241 50503547
Oral pain 12.32 11.46 7 59329 25026 50520762
Cardiac ablation 12.31 11.46 11 59325 1283 50544505
Varicose vein ruptured 12.23 11.46 4 59332 56 50545732
Breast discomfort 12.18 11.46 7 59329 406 50545382
Femoral neck fracture 12.11 11.46 27 59309 7463 50538325
Product quality issue 12.09 11.46 11 59325 30847 50514941
Abdominal wall haemorrhage 12.08 11.46 5 59331 140 50545648
Accidental exposure to product 12.01 11.46 6 59330 23051 50522737
Diet noncompliance 11.89 11.46 6 59330 268 50545520
Wound 11.84 11.46 74 59262 105720 50440068
Metastases to bone marrow 11.68 11.46 6 59330 278 50545510
Pickwickian syndrome 11.64 11.46 6 59330 280 50545508
Hepatocellular carcinoma 11.62 11.46 13 59323 1986 50543802
Anal haemorrhage 11.58 11.46 12 59324 1680 50544108
Patent ductus arteriosus 11.52 11.46 18 59318 3802 50541986
Abdominal pain upper 11.52 11.46 256 59080 159053 50386735

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 1373.47 11.68 1328 57388 101529 29414282
Cardiac failure 562.56 11.68 738 57978 78549 29437262
Oedema peripheral 496.95 11.68 801 57915 102756 29413055
Haematochezia 360.95 11.68 405 58311 36578 29479233
Dyspnoea 355.97 11.68 1432 57284 325300 29190511
Product monitoring error 338.25 11.68 144 58572 2501 29513310
Product prescribing error 337.12 11.68 282 58434 17694 29498117
Drug ineffective 243.23 11.68 219 58497 362951 29152860
Cardiac failure chronic 217.08 11.68 144 58572 6323 29509488
Anaemia 192.87 11.68 849 57867 200102 29315709
Electrocardiogram abnormal 178.29 11.68 134 58582 7188 29508623
N-terminal prohormone brain natriuretic peptide increased 151.86 11.68 75 58641 1857 29513954
Systemic infection 151.72 11.68 77 58639 2024 29513787
Toxicity to various agents 145.60 11.68 82 58634 173579 29342232
Syncope 145.33 11.68 422 58294 80949 29434862
Dizziness 142.39 11.68 747 57969 188937 29326874
Electrolyte imbalance 128.29 11.68 134 58582 11140 29504671
Off label use 124.50 11.68 257 58459 300543 29215268
Atrial fibrillation 123.62 11.68 475 58241 105171 29410640
Dyspnoea exertional 118.96 11.68 239 58477 36251 29479560
Bradycardia 117.74 11.68 341 58375 65288 29450523
Therapeutic drug monitoring analysis not performed 117.13 11.68 42 58674 448 29515363
Labelled drug-drug interaction medication error 111.43 11.68 129 58587 12030 29503781
Inferior vena cava dilatation 107.38 11.68 43 58673 634 29515177
Pallor 106.43 11.68 167 58549 20857 29494954
Glomerular filtration rate decreased 105.72 11.68 121 58595 11145 29504666
Drug abuse 103.80 11.68 17 58699 79866 29435945
Haematoma 102.07 11.68 173 58543 23039 29492772
Ventricular arrhythmia 98.41 11.68 78 58638 4526 29511285
Neutropenia 93.12 11.68 75 58641 131636 29384175
Angina pectoris 90.26 11.68 182 58534 27668 29488143
Renal impairment 89.64 11.68 359 58357 80974 29434837
Dyspnoea at rest 87.67 11.68 63 58653 3151 29512660
Condition aggravated 84.00 11.68 537 58179 145758 29370053
Right ventricular failure 83.07 11.68 90 58626 7800 29508011
Completed suicide 82.41 11.68 38 58678 90208 29425603
Wound 81.71 11.68 110 58606 11953 29503858
Acute kidney injury 81.56 11.68 844 57872 264423 29251388
Ventricular enlargement 75.43 11.68 30 58686 434 29515377
Exercise tolerance decreased 72.36 11.68 63 58653 4168 29511643
Melaena 72.04 11.68 178 58538 30998 29484813
Febrile neutropenia 71.98 11.68 70 58646 112170 29403641
Fall 71.07 11.68 597 58119 176581 29339230
Weight increased 70.23 11.68 320 58396 76347 29439464
Computerised tomogram coronary artery abnormal 69.88 11.68 23 58693 185 29515626
Hypotension 69.74 11.68 639 58077 193715 29322096
Infusion related reaction 67.90 11.68 5 58711 43881 29471930
Dehydration 65.67 11.68 421 58295 114327 29401484
Rash 62.71 11.68 182 58534 189637 29326174
Pulmonary hypertension 61.95 11.68 123 58593 18485 29497326
Cardiac aneurysm 61.91 11.68 31 58685 791 29515020
Fracture 61.90 11.68 68 58648 5985 29509826
Hyperuricaemia 59.64 11.68 71 58645 6818 29508993
Arrhythmia 59.30 11.68 166 58550 31147 29484664
Blood creatinine increased 58.76 11.68 328 58388 84774 29431037
Anxiety 57.35 11.68 51 58665 85314 29430497
Hypokalaemia 57.19 11.68 224 58492 49979 29465832
Hyperkalaemia 56.76 11.68 257 58459 61135 29454676
Low cardiac output syndrome 56.61 11.68 25 58691 476 29515335
Glomerular filtration rate abnormal 55.86 11.68 28 58688 716 29515095
Treatment failure 54.95 11.68 5 58711 36934 29478877
Ejection fraction decreased 54.86 11.68 107 58609 15871 29499940
Malaise 54.18 11.68 151 58565 159451 29356360
Febrile infection 54.01 11.68 39 58677 1965 29513846
Ventricular tachycardia 53.32 11.68 130 58586 22444 29493367
Neuropathy peripheral 53.28 11.68 38 58678 70989 29444822
Degenerative mitral valve disease 52.79 11.68 19 58697 205 29515606
Pulmonary arterial hypertension 52.09 11.68 69 58647 7380 29508431
Contraindicated product administered 50.61 11.68 112 58604 18154 29497657
Arthralgia 48.94 11.68 130 58586 139487 29376324
Pleural effusion 48.20 11.68 275 58441 71633 29444178
Mitral valve incompetence 48.07 11.68 91 58625 13202 29502609
Gamma-glutamyltransferase increased 47.95 11.68 139 58577 26598 29489213
Waist circumference increased 46.95 11.68 25 58691 727 29515084
Hepatic vein dilatation 44.81 11.68 17 58699 215 29515596
Drug hypersensitivity 44.60 11.68 42 58674 68364 29447447
Concomitant disease aggravated 44.24 11.68 52 58664 4926 29510885
Respiratory tract haemorrhage 43.75 11.68 26 58690 938 29514873
Left ventricular failure 43.69 11.68 50 58666 4603 29511208
Ventricular hypokinesia 42.77 11.68 49 58667 4516 29511295
Aortic valve incompetence 42.30 11.68 51 58665 4962 29510849
Foetal exposure during pregnancy 42.24 11.68 8 58708 33859 29481952
Musculoskeletal pain 42.16 11.68 140 58576 28813 29486998
Depression 42.01 11.68 65 58651 85082 29430729
Hepatojugular reflux 41.91 11.68 20 58696 458 29515353
Atrial enlargement 41.88 11.68 18 58698 320 29515491
Agitation 41.79 11.68 25 58691 51279 29464532
Product dose omission issue 41.69 11.68 80 58636 96303 29419508
Cardio-respiratory arrest 40.74 11.68 25 58691 50576 29465235
Chronic kidney disease 40.26 11.68 161 58555 36255 29479556
Urinary hesitation 39.97 11.68 34 58682 2179 29513632
Skin ulcer 39.79 11.68 104 58612 18736 29497075
Gastrointestinal haemorrhage 39.00 11.68 281 58435 79252 29436559
Bradyarrhythmia 38.97 11.68 32 58684 1953 29513858
Nicotine dependence 38.55 11.68 19 58697 468 29515343
Liver palpable 37.77 11.68 16 58700 274 29515537
Lethargy 37.22 11.68 14 58702 37566 29478245
Hypervolaemia 37.21 11.68 97 58619 17448 29498363
Cardiac failure acute 37.11 11.68 66 58650 9126 29506685
Tachyarrhythmia 36.87 11.68 37 58679 2932 29512879
Normocytic anaemia 36.79 11.68 31 58685 1961 29513850
Headache 36.33 11.68 200 58516 173807 29342004
Gastritis erosive 36.25 11.68 49 58667 5344 29510467
Fluid retention 36.17 11.68 116 58600 23444 29492367
Suicidal ideation 35.97 11.68 12 58704 34704 29481107
Pulmonary vascular disorder 35.51 11.68 19 58697 558 29515253
Infective exacerbation of chronic obstructive airways disease 35.36 11.68 28 58688 1622 29514189
Urticaria 35.11 11.68 34 58682 54626 29461185
Death 34.69 11.68 475 58241 341609 29174202
Deep vein thrombosis 34.27 11.68 38 58678 57361 29458450
Eye injury 34.09 11.68 19 58697 606 29515205
Intentional overdose 33.96 11.68 17 58699 38511 29477300
Acute abdomen 33.95 11.68 28 58688 1719 29514092
Brain natriuretic peptide increased 32.42 11.68 41 58675 4189 29511622
Injection site pain 32.28 11.68 12 58704 32434 29483377
Type V hyperlipidaemia 32.16 11.68 19 58697 678 29515133
Osteochondrosis 32.09 11.68 20 58696 787 29515024
Lower respiratory tract infection 31.51 11.68 7 58709 26495 29489316
Asthma 31.27 11.68 14 58702 33835 29481976
Renal cyst 30.93 11.68 56 58660 7851 29507960
Erysipelas 30.88 11.68 40 58676 4185 29511626
C-reactive protein increased 30.77 11.68 171 58545 44092 29471719
Circulatory collapse 30.56 11.68 94 58622 18579 29497232
Paresis 30.49 11.68 27 58689 1827 29513984
Therapeutic response decreased 30.47 11.68 6 58710 24705 29491106
Helicobacter test positive 30.42 11.68 18 58698 644 29515167
Coronary artery stenosis 30.14 11.68 58 58658 8515 29507296
Loss of personal independence in daily activities 29.69 11.68 7 58709 25433 29490378
Disease progression 29.65 11.68 75 58641 81841 29433970
Joint swelling 29.47 11.68 33 58683 49597 29466214
Low density lipoprotein abnormal 29.36 11.68 13 58703 249 29515562
Thirst 29.34 11.68 49 58667 6442 29509369
Bone marrow failure 29.31 11.68 9 58707 27440 29488371
Procalcitonin increased 29.19 11.68 25 58691 1617 29514194
Haematemesis 28.94 11.68 111 58605 24515 29491296
Jugular vein distension 28.74 11.68 17 58699 608 29515203
Cardiovascular insufficiency 28.49 11.68 23 58693 1370 29514441
Left atrial enlargement 28.29 11.68 18 58698 735 29515076
Musculoskeletal stiffness 28.13 11.68 20 58696 37438 29478373
Hypochromic anaemia 28.05 11.68 18 58698 746 29515065
Therapeutic product effect decreased 27.49 11.68 12 58704 29439 29486372
Hypersensitivity 27.43 11.68 39 58677 52864 29462947
Blood pressure decreased 27.29 11.68 169 58547 45308 29470503
Hypotonia 27.15 11.68 49 58667 6853 29508958
Prescribed underdose 26.55 11.68 52 58664 7734 29508077
Abdominal distension 26.54 11.68 169 58547 45742 29470069
Tachypnoea 26.54 11.68 78 58638 15037 29500774
Insomnia 26.49 11.68 89 58627 88672 29427139
Palisaded neutrophilic granulomatous dermatitis 26.12 11.68 5 58711 0 29515811
White blood cell count decreased 25.98 11.68 82 58634 83280 29432531
Rectal prolapse 25.80 11.68 12 58704 259 29515552
Abnormal behaviour 25.76 11.68 7 58709 23120 29492691
Therapeutic product effect incomplete 25.76 11.68 24 58692 39281 29476530
Diverticulum intestinal 25.39 11.68 32 58684 3258 29512553
Intentional product misuse 25.38 11.68 19 58697 34642 29481169
Heat stroke 25.21 11.68 18 58698 891 29514920
Sinusitis 24.94 11.68 19 58697 34331 29481480
Atrial flutter 24.68 11.68 72 58644 13822 29501989
Back pain 24.50 11.68 112 58604 102172 29413639
Micturition disorder 24.18 11.68 24 58692 1877 29513934
Orthopnoea 24.15 11.68 37 58679 4523 29511288
Product use in unapproved indication 24.00 11.68 90 58626 86785 29429026
Intestinal haemorrhage 23.84 11.68 30 58686 3049 29512762
Drug intolerance 23.78 11.68 37 58679 48342 29467469
Arteriosclerotic gangrene 23.61 11.68 8 58708 71 29515740
Cough 23.27 11.68 367 58349 126360 29389451
Pleurothotonus 23.07 11.68 18 58698 1020 29514791
Traumatic haemothorax 23.05 11.68 11 58705 252 29515559
Left ventricular enlargement 23.05 11.68 15 58701 637 29515174
Oedema 22.77 11.68 148 58568 40335 29475476
Renal function test abnormal 22.76 11.68 25 58691 2199 29513612
Osteonecrosis of jaw 22.61 11.68 3 58713 16507 29499304
Duodenitis 22.53 11.68 34 58682 4101 29511710
Blood glucose abnormal 22.48 11.68 38 58678 5045 29510766
Mitral valve thickening 22.17 11.68 12 58704 361 29515450
Suicide attempt 22.15 11.68 21 58695 34089 29481722
Post-traumatic amnestic disorder 22.11 11.68 7 58709 49 29515762
Arthritis 22.10 11.68 11 58705 25008 29490803
Pruritus 21.86 11.68 139 58577 116710 29399101
Vena cava injury 21.83 11.68 10 58706 208 29515603
Peripheral venous disease 21.83 11.68 25 58691 2303 29513508
Pulmonary congestion 21.66 11.68 64 58652 12372 29503439
SARS-CoV-2 antibody test positive 21.20 11.68 10 58706 223 29515588
Nephrolithiasis 21.11 11.68 12 58704 25322 29490489
Congestive cardiomyopathy 21.07 11.68 43 58673 6587 29509224
Skin pressure mark 20.98 11.68 7 58709 59 29515752
Immobile 20.87 11.68 24 58692 2221 29513590
Ascites 20.67 11.68 134 58582 36485 29479326
Nasopharyngitis 20.54 11.68 56 58660 59609 29456202
Intraductal papillary mucinous neoplasm 20.38 11.68 11 58705 329 29515482
Urosepsis 20.36 11.68 57 58659 10689 29505122
Hepatic calcification 20.26 11.68 11 58705 333 29515478
Cardiovascular somatic symptom disorder 19.88 11.68 6 58710 35 29515776
Neuroleptic malignant syndrome 19.74 11.68 4 58712 16144 29499667
Product used for unknown indication 19.73 11.68 11 58705 351 29515460
Rhinorrhoea 19.72 11.68 9 58707 21510 29494301
Atrial thrombosis 19.70 11.68 22 58694 1971 29513840
Premature baby 19.69 11.68 5 58711 17275 29498536
Stress 19.67 11.68 9 58707 21481 29494330
Drug reaction with eosinophilia and systemic symptoms 19.67 11.68 16 58700 27976 29487835
Colitis 19.41 11.68 20 58696 31228 29484583
Drug withdrawal syndrome 19.01 11.68 6 58710 17978 29497833
Paraesthesia 18.94 11.68 50 58666 53795 29462016
Blood pressure systolic decreased 18.70 11.68 30 58686 3814 29511997
Product use issue 18.68 11.68 47 58669 51397 29464414
Cardiac amyloidosis 18.66 11.68 15 58701 888 29514923
Renal cyst haemorrhage 18.58 11.68 11 58705 394 29515417
Drug interaction 18.55 11.68 518 58198 196867 29318944
Psoriasis 18.51 11.68 22 58694 32205 29483606
Drug ineffective for unapproved indication 18.50 11.68 3 58713 14211 29501600
Influenza like illness 18.46 11.68 13 58703 24457 29491354
Rheumatoid arthritis 18.41 11.68 22 58694 32130 29483681
Blood loss anaemia 18.40 11.68 43 58673 7223 29508588
Renal failure 18.31 11.68 334 58382 118265 29397546
Type 2 diabetes mellitus 18.30 11.68 64 58652 13517 29502294
Internal haemorrhage 18.15 11.68 32 58684 4395 29511416
Systolic dysfunction 18.12 11.68 22 58694 2156 29513655
Encephalopathy 18.04 11.68 21 58695 31022 29484789
Akinesia 18.04 11.68 21 58695 1969 29513842
Genitourinary tract infection 17.87 11.68 7 58709 97 29515714
Respiratory arrest 17.86 11.68 15 58701 25818 29489993
Mental status changes 17.85 11.68 26 58690 34901 29480910
Scrotal oedema 17.73 11.68 18 58698 1446 29514365
Cardiorenal syndrome 17.69 11.68 13 58703 673 29515138
Acute respiratory failure 17.68 11.68 101 58615 26301 29489510
Acute respiratory distress syndrome 17.54 11.68 12 58704 22923 29492888
Periarthritis calcarea 17.54 11.68 6 58710 55 29515756
Costal cartilage fracture 17.48 11.68 9 58707 244 29515567
Obesity 17.41 11.68 51 58665 9812 29505999
Tricuspid valve incompetence 17.38 11.68 46 58670 8348 29507463
Abdominal wall haemorrhage 17.38 11.68 9 58707 247 29515564
Peripheral artery stenosis 17.35 11.68 14 58702 833 29514978
Disorientation 17.27 11.68 109 58607 29406 29486405
Neutrophil count decreased 17.26 11.68 38 58678 43529 29472282
Articular calcification 17.26 11.68 6 58710 58 29515753
Insulin autoimmune syndrome 17.15 11.68 9 58707 254 29515557
Haemothorax 16.97 11.68 27 58689 3409 29512402
Haemoptysis 16.76 11.68 111 58605 30439 29485372
Thoracic haemorrhage 16.69 11.68 8 58708 185 29515626
Unevaluable event 16.49 11.68 21 58695 29830 29485981
Small intestinal obstruction 16.47 11.68 3 58713 13058 29502753
N-terminal prohormone brain natriuretic peptide abnormal 16.46 11.68 8 58708 191 29515620
Sedation 16.39 11.68 7 58709 17398 29498413
Hypertensive crisis 16.24 11.68 43 58673 7805 29508006
Peripheral arterial occlusive disease 16.23 11.68 33 58683 5043 29510768
Hiatus hernia 16.06 11.68 39 58677 6713 29509098
Blood glucose fluctuation 16.05 11.68 27 58689 3570 29512241
Intraventricular haemorrhage 15.98 11.68 24 58692 2882 29512929
Coma 15.97 11.68 34 58682 39416 29476395
Vision blurred 15.95 11.68 35 58681 40141 29475670
Glycosylated haemoglobin increased 15.93 11.68 48 58668 9378 29506433
Interstitial lung disease 15.80 11.68 60 58656 57658 29458153
Dysuria 15.79 11.68 87 58629 22353 29493458
Mitral valve calcification 15.76 11.68 11 58705 525 29515286
Immature granulocyte count increased 15.73 11.68 6 58710 77 29515734
Cardiac failure congestive 15.67 11.68 226 58490 76355 29439456
COVID-19 pneumonia 15.64 11.68 48 58668 9474 29506337
Iron deficiency anaemia 15.56 11.68 46 58670 8896 29506915
Drug resistance 15.52 11.68 12 58704 21528 29494283
Cytomegalovirus infection 15.42 11.68 14 58702 23201 29492610
Mucosal haemorrhage 15.40 11.68 17 58699 1504 29514307
Adrenal cyst 15.39 11.68 6 58710 82 29515729
Migraine 15.36 11.68 3 58713 12427 29503384
Psoriatic arthropathy 15.35 11.68 5 58711 14686 29501125
Aortic dilatation 15.34 11.68 14 58702 985 29514826
Product prescribing issue 15.34 11.68 15 58701 1152 29514659
Congenital vas deferens absence 15.32 11.68 5 58711 39 29515772
Non-compaction cardiomyopathy 15.32 11.68 5 58711 39 29515772
Congenital muscle absence 15.32 11.68 5 58711 39 29515772
Delayed graft function 15.28 11.68 19 58697 1908 29513903
Disturbance in attention 15.04 11.68 83 58633 21341 29494470
Prothrombin time prolonged 14.95 11.68 45 58671 8787 29507024
Blood potassium abnormal 14.82 11.68 14 58702 1030 29514781
Bladder tamponade 14.81 11.68 10 58706 452 29515359
Stress urinary incontinence 14.59 11.68 6 58710 95 29515716
Adrenomegaly 14.58 11.68 9 58707 348 29515463
Anhidrosis 14.31 11.68 6 58710 100 29515711
Abdominal discomfort 14.30 11.68 48 58668 47855 29467956
Blast cells present 14.26 11.68 10 58706 481 29515330
Albumin urine present 14.22 11.68 9 58707 364 29515447
Blood pressure increased 14.20 11.68 87 58629 73716 29442095
Vitamin B6 deficiency 14.15 11.68 7 58709 174 29515637
Sudden cardiac death 14.13 11.68 24 58692 3198 29512613
Oxygen saturation decreased 14.13 11.68 44 58672 44893 29470918
Blood potassium increased 14.02 11.68 62 58654 14589 29501222
Pulmonary oedema 14.00 11.68 138 58578 42597 29473214
Irritability 13.96 11.68 14 58702 22138 29493673
Diabetic nephropathy 13.94 11.68 18 58698 1877 29513934
Metamyelocyte count increased 13.94 11.68 9 58707 377 29515434
Seizure 13.93 11.68 118 58598 93005 29422806
Influenza 13.90 11.68 40 58676 41841 29473970
Right ventricular enlargement 13.86 11.68 7 58709 182 29515629
Psychotic disorder 13.85 11.68 12 58704 20342 29495469
Urogenital infection bacterial 13.72 11.68 5 58711 56 29515755
Abdominal pain lower 13.68 11.68 43 58673 8595 29507216
Polypectomy 13.67 11.68 10 58706 514 29515297
Respiratory distress 13.56 11.68 27 58689 32079 29483732
Dysdiadochokinesis 13.55 11.68 7 58709 191 29515620
Tremor 13.48 11.68 88 58628 73450 29442361
Intentional self-injury 13.46 11.68 4 58712 12457 29503354
Overdose 13.40 11.68 98 58618 79721 29436090
Hanging 13.32 11.68 6 58710 120 29515691
Nephrogenic anaemia 13.28 11.68 18 58698 1967 29513844
Hallucination 13.21 11.68 45 58671 44667 29471144
Subclavian artery occlusion 13.18 11.68 6 58710 123 29515688
Rash erythematous 13.17 11.68 14 58702 21548 29494263
Left ventricular hypertrophy 13.14 11.68 36 58680 6667 29509144
Groin abscess 13.06 11.68 10 58706 551 29515260
Hyperglycaemia 12.87 11.68 114 58602 34173 29481638
Oedematous pancreatitis 12.70 11.68 9 58707 440 29515371
Activated partial thromboplastin time prolonged 12.69 11.68 39 58677 7703 29508108
Eye contusion 12.68 11.68 9 58707 441 29515370
Hypertrophy 12.67 11.68 9 58707 442 29515369
Sinus arrest 12.67 11.68 15 58701 1432 29514379
Hepatorenal syndrome 12.62 11.68 19 58697 2287 29513524
Arterial haemorrhage 12.56 11.68 11 58705 733 29515078
Oesophagitis 12.56 11.68 4 58712 11919 29503892
Fear of falling 12.54 11.68 8 58708 328 29515483
Benign gastrointestinal neoplasm 12.51 11.68 6 58710 139 29515672
Hyperparathyroidism secondary 12.48 11.68 14 58702 1261 29514550
Hyperhidrosis 12.46 11.68 76 58640 64464 29451347
Pulmonary mass 12.46 11.68 3 58713 10745 29505066
Hepatitis E antibody positive 12.43 11.68 6 58710 141 29515670
Gallbladder hypofunction 12.39 11.68 3 58713 6 29515805
Pain 12.38 11.68 253 58463 171179 29344632
Haematuria 12.32 11.68 138 58578 44001 29471810
Spinal cord injury cauda equina 12.24 11.68 6 58710 146 29515665
Therapy non-responder 12.21 11.68 27 58689 30884 29484927
Pancreatitis 12.17 11.68 32 58684 34482 29481329
Dyspepsia 12.16 11.68 26 58690 30099 29485712
Aortic arteriosclerosis 12.16 11.68 25 58691 3851 29511960
Haemoglobin decreased 12.07 11.68 291 58425 108084 29407727
Vomiting 12.06 11.68 325 58391 211935 29303876
Cardiac ventricular disorder 12.05 11.68 7 58709 242 29515569
Somatosensory evoked potentials abnormal 12.02 11.68 6 58710 152 29515659
Myelocyte count increased 11.98 11.68 8 58708 355 29515456
Plasma cell myeloma 11.91 11.68 36 58680 37079 29478732
Pulmonary embolism 11.89 11.68 96 58620 76438 29439373
Atrioventricular block complete 11.89 11.68 39 58677 7972 29507839
Bacteraemia 11.88 11.68 9 58707 16314 29499497
Diplopia 11.85 11.68 6 58710 13512 29502299
Eosinophilia 11.82 11.68 16 58700 22145 29493666
Aggression 11.75 11.68 34 58682 35507 29480304
Intentional product use issue 11.74 11.68 44 58672 42454 29473357

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 2914.66 11.25 2516 103184 201909 64191123
Product prescribing error 1011.69 11.25 662 105038 34607 64358425
Haematochezia 857.68 11.25 775 104925 65598 64327434
Cardiac failure 826.04 11.25 1050 104650 131323 64261709
Product monitoring error 823.63 11.25 317 105383 5137 64387895
Oedema peripheral 762.82 11.25 1291 104409 209026 64184006
Dyspnoea 660.98 11.25 2618 103082 716056 63676976
Drug ineffective 585.13 11.25 327 105373 839920 63553112
Anaemia 449.01 11.25 1501 104199 377179 64015853
Systemic infection 358.56 11.25 164 105536 4157 64388875
Syncope 333.83 11.25 773 104927 156862 64236170
Renal impairment 322.79 11.25 695 105005 134322 64258710
Atrial fibrillation 311.01 11.25 791 104909 170298 64222734
Bradycardia 305.19 11.25 628 105072 117591 64275441
Electrolyte imbalance 297.08 11.25 280 105420 24963 64368069
Labelled drug-drug interaction medication error 293.30 11.25 262 105438 21800 64371232
Dehydration 289.58 11.25 896 104804 215867 64177165
Cardiac failure chronic 259.74 11.25 170 105530 8871 64384161
Off label use 250.32 11.25 408 105292 632398 63760634
Acute kidney injury 241.36 11.25 1405 104295 447835 63945197
Pallor 240.35 11.25 307 105393 38474 64354558
Dizziness 224.97 11.25 1336 104364 428827 63964205
Therapeutic drug monitoring analysis not performed 221.38 11.25 81 105619 1131 64391901
Fall 213.71 11.25 1288 104412 415538 63977494
Electrocardiogram abnormal 213.53 11.25 177 105523 13304 64379728
Completed suicide 208.73 11.25 55 105645 224359 64168673
Rash 200.09 11.25 276 105424 458273 63934759
Infusion related reaction 195.23 11.25 21 105679 164446 64228586
Joint swelling 190.64 11.25 58 105642 215324 64177708
Hypotension 189.96 11.25 1169 104531 379805 64013227
Pulmonary arterial hypertension 189.96 11.25 221 105479 25146 64367886
Drug hypersensitivity 186.71 11.25 78 105622 237737 64155295
Dyspnoea exertional 176.55 11.25 380 105320 73350 64319682
Toxicity to various agents 175.99 11.25 202 105498 363311 64029721
N-terminal prohormone brain natriuretic peptide increased 170.40 11.25 93 105607 3466 64389566
Arrhythmia 166.67 11.25 306 105394 52638 64340394
Glomerular filtration rate decreased 160.94 11.25 179 105521 19393 64373639
Angina pectoris 160.52 11.25 275 105425 44806 64348226
Drug intolerance 160.35 11.25 54 105646 187938 64205094
Right ventricular failure 155.68 11.25 184 105516 21287 64371745
Treatment failure 155.08 11.25 9 105691 116807 64276225
Haematemesis 153.47 11.25 276 105424 46723 64346309
Synovitis 147.53 11.25 3 105697 99087 64293945
Arthropathy 144.68 11.25 15 105685 120952 64272080
Fluid retention 141.30 11.25 306 105394 59300 64333732
Melaena 141.02 11.25 287 105413 53261 64339771
Hypersensitivity 140.91 11.25 73 105627 196379 64196653
Rheumatoid arthritis 138.70 11.25 48 105652 164246 64228786
Hyperkalaemia 138.46 11.25 422 105278 100707 64292325
Haematoma 136.45 11.25 260 105440 45990 64347042
Arthralgia 131.97 11.25 335 105365 441925 63951107
Drug abuse 131.78 11.25 28 105672 132346 64260686
Therapeutic product effect decreased 128.85 11.25 18 105682 115333 64277699
Drug interaction 121.93 11.25 1011 104689 361072 64031960
Lower respiratory tract infection 117.74 11.25 10 105690 94604 64298428
Hypervolaemia 117.62 11.25 219 105481 38066 64354966
Pulmonary hypertension 114.52 11.25 232 105468 42907 64350125
Hypokalaemia 113.87 11.25 448 105252 121455 64271577
Blood creatinine increased 112.62 11.25 481 105219 135301 64257731
Inferior vena cava dilatation 110.88 11.25 43 105657 711 64392321
Musculoskeletal stiffness 107.47 11.25 34 105666 123172 64269860
Product administration error 106.89 11.25 175 105525 27468 64365564
Injection site pain 106.02 11.25 26 105674 111382 64281650
Febrile neutropenia 103.52 11.25 93 105607 187564 64205468
Exercise tolerance decreased 103.31 11.25 92 105608 7618 64385414
Alopecia 100.22 11.25 75 105625 165615 64227417
Pain 100.16 11.25 517 105183 552994 63840038
Orthostatic intolerance 100.04 11.25 50 105650 1550 64391482
Malaise 99.91 11.25 325 105375 395922 63997110
Gastrointestinal haemorrhage 99.34 11.25 455 105245 131857 64261175
Ventricular arrhythmia 98.41 11.25 88 105612 7327 64385705
Nasopharyngitis 96.88 11.25 107 105593 195966 64197066
Sinusitis 96.33 11.25 60 105640 145868 64247164
Condition aggravated 94.59 11.25 979 104721 371447 64021585
Systemic lupus erythematosus 94.42 11.25 9 105691 77603 64315429
Mitral valve incompetence 92.49 11.25 157 105543 25381 64367651
Glossodynia 92.38 11.25 3 105697 64693 64328339
Dyspnoea at rest 91.79 11.25 79 105621 6250 64386782
Urticaria 91.28 11.25 65 105635 147252 64245780
Anxiety 88.14 11.25 122 105578 202527 64190505
Neutropenia 87.51 11.25 162 105538 239462 64153570
Fracture 86.82 11.25 129 105571 18626 64374406
Chronic kidney disease 85.21 11.25 248 105452 57671 64335361
Pleural effusion 82.55 11.25 418 105282 126141 64266891
Ventricular enlargement 77.52 11.25 30 105670 493 64392539
Renal failure 77.12 11.25 536 105164 181152 64211880
Blood loss anaemia 75.27 11.25 103 105597 13789 64379243
Tachyarrhythmia 75.03 11.25 69 105631 5957 64387075
Pruritus 74.74 11.25 262 105438 312138 64080894
Computerised tomogram coronary artery abnormal 74.21 11.25 23 105677 185 64392847
Cardiac failure acute 73.63 11.25 111 105589 16233 64376799
Arthritis 73.31 11.25 23 105677 83791 64309241
Hyperglycaemia 72.09 11.25 242 105458 60726 64332306
Anuria 70.55 11.25 118 105582 18846 64374186
Product use issue 70.40 11.25 87 105613 151628 64241404
Abdominal discomfort 69.47 11.25 120 105580 182202 64210830
Therapeutic product effect incomplete 69.04 11.25 42 105658 103440 64289592
Glomerular filtration rate abnormal 69.00 11.25 36 105664 1223 64391809
Back pain 68.81 11.25 197 105503 249974 64143058
Neuropathy peripheral 68.76 11.25 55 105645 117470 64275562
Tachypnoea 68.26 11.25 141 105559 26430 64366602
Disorientation 67.25 11.25 223 105477 55605 64337427
Waist circumference increased 66.12 11.25 36 105664 1335 64391697
Gamma-glutamyltransferase increased 65.94 11.25 202 105498 48308 64344724
Atrial flutter 64.77 11.25 115 105585 19265 64373767
Renal function test abnormal 62.55 11.25 52 105648 3922 64389110
Circulatory collapse 62.21 11.25 157 105543 33575 64359457
Cardio-respiratory arrest 61.48 11.25 43 105657 98350 64294682
Headache 61.17 11.25 564 105136 528903 63864129
Depression 59.98 11.25 132 105568 183159 64209873
Cardiac aneurysm 59.59 11.25 33 105667 1266 64391766
Discomfort 59.52 11.25 29 105671 80849 64312183
Pancreatic steatosis 58.63 11.25 30 105670 978 64392054
Thirst 58.06 11.25 92 105608 14045 64378987
Swelling 57.85 11.25 109 105591 160109 64232923
Hepatic enzyme increased 57.71 11.25 77 105623 129866 64263166
Injection site erythema 57.49 11.25 22 105678 70778 64322254
Product use in unapproved indication 57.13 11.25 128 105572 176490 64216542
Medication error 57.02 11.25 196 105504 49770 64343262
Tricuspid valve incompetence 56.96 11.25 101 105599 16902 64376130
Ventricular tachycardia 56.56 11.25 153 105547 34112 64358920
Loss of personal independence in daily activities 56.41 11.25 24 105676 72430 64320602
Left ventricular failure 55.89 11.25 69 105631 8348 64384684
Hyperuricaemia 55.88 11.25 76 105624 10115 64382917
Musculoskeletal pain 55.46 11.25 272 105428 81022 64312010
Bradyarrhythmia 54.69 11.25 47 105653 3711 64389321
Maternal exposure during pregnancy 54.68 11.25 46 105654 95838 64297194
Diverticulum intestinal 54.46 11.25 64 105636 7356 64385676
Degenerative mitral valve disease 53.80 11.25 19 105681 238 64392794
Hyponatraemia 53.45 11.25 421 105279 147918 64245114
Cardiac failure congestive 52.91 11.25 381 105319 130199 64262833
Oedema 51.98 11.25 292 105408 91643 64301389
Lethargy 51.97 11.25 27 105673 72567 64320465
Paraesthesia 51.72 11.25 88 105612 134434 64258598
Abdominal distension 51.72 11.25 301 105399 95693 64297339
Internal haemorrhage 51.15 11.25 63 105637 7604 64385428
Insomnia 50.64 11.25 161 105539 197675 64195357
Injection site reaction 50.44 11.25 8 105692 46656 64346376
Respiratory tract haemorrhage 50.34 11.25 31 105669 1453 64391579
Low density lipoprotein abnormal 50.08 11.25 19 105681 295 64392737
Arterial haemorrhage 50.00 11.25 36 105664 2195 64390837
Febrile infection 49.96 11.25 40 105660 2861 64390171
Helicobacter test positive 48.96 11.25 27 105673 1027 64392005
Suicidal ideation 48.75 11.25 24 105676 66518 64326514
Urinary hesitation 47.26 11.25 42 105658 3468 64389564
Erysipelas 47.20 11.25 66 105634 9015 64384017
Asthma 46.96 11.25 52 105648 95173 64297859
Hepatic vein dilatation 46.88 11.25 17 105683 231 64392801
Haemoglobin decreased 46.68 11.25 507 105193 194556 64198476
Exposure during pregnancy 45.87 11.25 36 105664 77639 64315393
Aortic valve incompetence 45.66 11.25 62 105638 8239 64384793
Flatulence 45.23 11.25 145 105555 35521 64357511
Ejection fraction decreased 45.21 11.25 126 105574 28581 64364451
Pericarditis 45.12 11.25 23 105677 62493 64330539
Stomatitis 44.66 11.25 69 105631 109536 64283496
Low cardiac output syndrome 44.34 11.25 23 105677 772 64392260
Hepatojugular reflux 43.71 11.25 20 105680 507 64392525
Oropharyngeal pain 43.30 11.25 49 105651 88818 64304214
Gastrointestinal disorder 43.13 11.25 50 105650 89659 64303373
Aortic valve stenosis 43.11 11.25 45 105655 4535 64388497
Therapeutic response decreased 42.73 11.25 16 105684 52172 64340860
Ventricular hypokinesia 42.69 11.25 58 105642 7711 64385321
Lymphatic fistula 42.48 11.25 22 105678 736 64392296
Haematuria 42.44 11.25 204 105496 60267 64332765
Cardiogenic shock 41.27 11.25 132 105568 32295 64360737
Orthopnoea 41.09 11.25 62 105638 9072 64383960
Blood urea increased 40.96 11.25 162 105538 43991 64349041
Product used for unknown indication 40.60 11.25 22 105678 808 64392224
Intentional product use issue 39.85 11.25 59 105641 95305 64297727
Pulmonary congestion 39.78 11.25 107 105593 23773 64369259
Femoral hernia incarcerated 39.55 11.25 21 105679 740 64392292
Psoriatic arthropathy 39.44 11.25 11 105689 43270 64349762
Concomitant disease aggravated 39.22 11.25 69 105631 11473 64381559
N-terminal prohormone brain natriuretic peptide abnormal 39.19 11.25 15 105685 239 64392793
Coma 38.81 11.25 52 105648 87563 64305469
Gastritis erosive 38.79 11.25 62 105638 9533 64383499
Dysuria 38.77 11.25 154 105546 41903 64351129
Tachycardia 38.69 11.25 395 105305 149184 64243848
Joint stiffness 38.41 11.25 3 105697 30401 64362631
Helicobacter infection 38.39 11.25 8 105692 38354 64354678
Migraine 38.35 11.25 28 105672 62649 64330383
Pulmonary vascular disorder 38.28 11.25 22 105678 907 64392125
Liver palpable 37.96 11.25 16 105684 331 64392701
Anaphylactic reaction 37.86 11.25 34 105666 68630 64324402
Lactic acidosis 37.36 11.25 199 105501 61211 64331821
Ascites 37.09 11.25 200 105500 61801 64331231
Stress 37.09 11.25 27 105673 60507 64332525
Injection site swelling 36.78 11.25 11 105689 41342 64351690
Psoriasis 36.64 11.25 38 105662 71665 64321367
Transfusion 36.63 11.25 87 105613 17907 64375125
Coronary artery stenosis 36.63 11.25 66 105634 11182 64381850
Intentional self-injury 36.31 11.25 3 105697 29041 64363991
Brain natriuretic peptide increased 36.04 11.25 53 105647 7580 64385452
Urosepsis 35.80 11.25 98 105602 21996 64371036
Acute respiratory failure 35.43 11.25 169 105531 49765 64343267
Retrograde amnesia 35.40 11.25 17 105683 482 64392550
Atrioventricular block complete 35.27 11.25 75 105625 14343 64378689
Folliculitis 35.25 11.25 4 105696 30073 64362959
Prothrombin time prolonged 35.23 11.25 79 105621 15662 64377370
Peripheral arterial occlusive disease 35.16 11.25 50 105650 6937 64386095
Hypoglycaemia 35.08 11.25 260 105440 89632 64303400
Irritable bowel syndrome 35.00 11.25 9 105691 37360 64355672
Osteonecrosis of jaw 34.69 11.25 11 105689 39814 64353218
Blood pressure systolic increased 34.50 11.25 19 105681 49434 64343598
Coagulation test abnormal 34.50 11.25 22 105678 1097 64391935
Drug ineffective for unapproved indication 34.42 11.25 5 105695 31128 64361904
Left-to-right cardiac shunt 34.21 11.25 11 105689 101 64392931
Blood potassium increased 34.20 11.25 107 105593 25873 64367159
Haemoptysis 34.08 11.25 165 105535 48883 64344149
Atrial enlargement 33.70 11.25 18 105682 642 64392390
Injection site bruising 33.61 11.25 9 105691 36364 64356668
Osteochondrosis 33.34 11.25 24 105676 1463 64391569
Nicotine dependence 32.81 11.25 19 105681 795 64392237
Vascular resistance pulmonary decreased 32.76 11.25 10 105690 76 64392956
Intentional overdose 32.62 11.25 61 105639 89883 64303149
Infective exacerbation of chronic obstructive airways disease 32.48 11.25 29 105671 2409 64390623
Cardioversion 32.48 11.25 26 105674 1859 64391173
Injection site pruritus 31.98 11.25 11 105689 37815 64355217
Blood pressure fluctuation 31.96 11.25 23 105677 51848 64341184
Hypotonia 31.79 11.25 62 105638 11150 64381882
White blood cell count decreased 31.57 11.25 142 105558 157695 64235337
Disturbance in attention 31.34 11.25 142 105558 40932 64352100
Product dose omission issue 31.21 11.25 189 105511 194558 64198474
Weight increased 31.17 11.25 507 105193 212841 64180191
Influenza 30.66 11.25 82 105618 106449 64286583
Cardiovascular insufficiency 30.65 11.25 29 105671 2595 64390437
Blood uric acid increased 30.64 11.25 51 105649 8112 64384920
Type V hyperlipidaemia 30.62 11.25 19 105681 903 64392129
Faecaloma 30.31 11.25 56 105644 9672 64383360
Peripheral circulatory failure 30.18 11.25 17 105683 674 64392358
Glycosylated haemoglobin increased 30.00 11.25 75 105625 15944 64377088
Intentional product misuse 29.94 11.25 45 105655 72250 64320782
Vena cava injury 29.91 11.25 12 105688 218 64392814
Aortic arteriosclerosis 29.80 11.25 48 105652 7428 64385604
Sleep disorder due to general medical condition, insomnia type 29.55 11.25 4 105696 26266 64366766
Rhinorrhoea 29.29 11.25 33 105667 59936 64333096
Blister 29.28 11.25 55 105645 80912 64312120
Fibromyalgia 29.17 11.25 11 105689 35720 64357312
Cholestatic liver injury 29.13 11.25 33 105667 3646 64389386
Hypoaesthesia 29.13 11.25 123 105577 138985 64254047
Jugular vein distension 28.87 11.25 21 105679 1301 64391731
Abdominal wall haemorrhage 28.71 11.25 14 105686 411 64392621
Left atrial enlargement 28.65 11.25 19 105681 1013 64392019
Abdominal pain lower 28.61 11.25 102 105598 26367 64366665
Agitation 28.59 11.25 64 105636 88303 64304729
Multiple sclerosis relapse 28.41 11.25 16 105684 41119 64351913
Respiratory arrest 28.31 11.25 27 105673 52958 64340074
Gastroenteritis clostridial 28.23 11.25 17 105683 765 64392267
Procalcitonin increased 28.09 11.25 27 105673 2464 64390568
Influenza like illness 27.96 11.25 36 105664 61666 64331366
Skin ulcer 27.77 11.25 144 105556 43830 64349202
Left ventricular enlargement 27.66 11.25 16 105684 668 64392364
Neutrophil count decreased 27.42 11.25 53 105647 77143 64315889
Stasis dermatitis 27.38 11.25 19 105681 1092 64391940
Epistaxis 27.23 11.25 263 105437 97868 64295164
Eye injury 27.13 11.25 22 105678 1602 64391430
Pulmonary oedema 27.07 11.25 221 105479 78453 64314579
Renal cyst 26.92 11.25 62 105638 12508 64380524
Tooth erosion 26.65 11.25 13 105687 382 64392650
Mental status changes 26.38 11.25 37 105663 61125 64331907
Sudden cardiac death 26.36 11.25 35 105665 4552 64388480
Mobility decreased 26.30 11.25 64 105636 85776 64307256
Wound infection pseudomonas 26.10 11.25 21 105679 1512 64391520
Nephrolithiasis 26.10 11.25 20 105680 43663 64349369
Blood pressure decreased 25.91 11.25 235 105465 85964 64307068
Hyperparathyroidism secondary 25.80 11.25 25 105675 2305 64390727
Rhonchi 25.63 11.25 30 105670 3433 64389599
Hypochromic anaemia 25.46 11.25 25 105675 2343 64390689
Cardiorenal syndrome 25.37 11.25 19 105681 1231 64391801
Blood pressure increased 25.32 11.25 172 105528 172380 64220652
Atrial thrombosis 25.31 11.25 28 105672 3014 64390018
Dry eye 25.30 11.25 8 105692 29011 64364021
Acute abdomen 25.25 11.25 27 105673 2797 64390235
Coronavirus test positive 25.18 11.25 17 105683 934 64392098
Duodenitis 25.14 11.25 42 105658 6699 64386333
Herpes zoster 25.09 11.25 58 105642 79129 64313903
Injury 25.03 11.25 33 105667 55959 64337073
Crush syndrome 25.01 11.25 10 105690 180 64392852
Arteriosclerotic gangrene 24.92 11.25 8 105692 73 64392959
Neurotoxicity 24.91 11.25 7 105693 27397 64365635
Palisaded neutrophilic granulomatous dermatitis 24.73 11.25 5 105695 3 64393029
C-reactive protein increased 24.70 11.25 251 105449 94658 64298374
Burning sensation 24.61 11.25 27 105673 49637 64343395
Polyuria 24.52 11.25 60 105640 12583 64380449
Pulmonary vein occlusion 24.44 11.25 9 105691 128 64392904
Gout 24.42 11.25 84 105616 21329 64371703
Pericardial effusion 24.42 11.25 128 105572 39126 64353906
Intraventricular haemorrhage 24.34 11.25 32 105668 4121 64388911
Upper gastrointestinal haemorrhage 24.12 11.25 118 105582 35102 64357930
Eructation 23.87 11.25 49 105651 9142 64383890
Scrotal oedema 23.73 11.25 18 105682 1189 64391843
Traumatic haemothorax 23.54 11.25 12 105688 388 64392644
Prescribed underdose 23.53 11.25 74 105626 17941 64375091
Emotional distress 23.51 11.25 15 105685 36023 64357009
Bundle branch block right 23.50 11.25 52 105648 10217 64382815
Drug withdrawal syndrome 23.35 11.25 11 105689 31280 64361752
Post-traumatic amnestic disorder 23.19 11.25 7 105693 51 64392981
Hyperthyroidism 23.13 11.25 74 105626 18105 64374927
Osteoarthritis 22.92 11.25 43 105657 63293 64329739
Pain in extremity 22.90 11.25 354 105346 302731 64090301
Obstructive airways disorder 22.86 11.25 5 105695 23180 64369852
Heat stroke 22.82 11.25 19 105681 1436 64391596
Feeling abnormal 22.82 11.25 127 105573 133475 64259557
Fungal infection 22.70 11.25 14 105686 34237 64358795
Seroma 22.67 11.25 22 105678 2032 64391000
SARS-CoV-2 antibody test positive 22.40 11.25 10 105690 239 64392793
Drug resistance 22.37 11.25 15 105685 35087 64357945
Serotonin syndrome 22.20 11.25 19 105681 39263 64353769
Paresis 21.93 11.25 28 105672 3504 64389528
Normocytic anaemia 21.83 11.25 27 105673 3272 64389760
Ill-defined disorder 21.77 11.25 24 105676 44028 64349004
Lower gastrointestinal haemorrhage 21.77 11.25 61 105639 13878 64379154
Hepatic calcification 21.66 11.25 11 105689 353 64392679
Rash pruritic 21.64 11.25 38 105662 57366 64335666
Pregnancy 21.62 11.25 4 105696 20861 64372171
Anal haemorrhage 21.57 11.25 27 105673 3313 64389719
Oral pain 21.57 11.25 9 105691 27484 64365548
Haemorrhagic erosive gastritis 21.53 11.25 12 105688 466 64392566
Administration site discomfort 21.28 11.25 8 105692 121 64392911
Therapy non-responder 21.09 11.25 48 105652 65851 64327181
Poor quality sleep 21.05 11.25 3 105697 18948 64374084
Congestive cardiomyopathy 21.04 11.25 50 105650 10294 64382738
Depressed level of consciousness 21.01 11.25 215 105485 81221 64311811
Suicide attempt 20.93 11.25 54 105646 70953 64322079
Cardiovascular somatic symptom disorder 20.88 11.25 6 105694 36 64392996
Throat irritation 20.82 11.25 14 105686 32697 64360335
Hiatus hernia 20.80 11.25 76 105624 19881 64373151
Mitral valve thickening 20.65 11.25 11 105689 390 64392642
Cardiovascular disorder 20.53 11.25 65 105635 15816 64377216
Irritability 20.49 11.25 18 105682 36728 64356304
Fracture blisters 20.48 11.25 7 105693 79 64392953
Skin pressure mark 20.48 11.25 7 105693 79 64392953
Asthenia 20.48 11.25 877 104823 427167 63965865
Rash erythematous 20.40 11.25 30 105670 48603 64344429
Thrombin time prolonged 20.10 11.25 10 105690 307 64392725
Haemarthrosis 20.07 11.25 33 105667 5196 64387836
Blood cholesterol increased 19.93 11.25 32 105668 50034 64342998
Helplessness 19.83 11.25 10 105690 316 64392716
Cytomegalovirus infection 19.82 11.25 19 105681 37180 64355852
Bone marrow failure 19.71 11.25 30 105670 47922 64345110
Micturition disorder 19.62 11.25 25 105675 3123 64389909
Infection 19.55 11.25 201 105499 184679 64208353
Oral herpes 19.51 11.25 6 105694 22146 64370886
Neoplasm progression 19.50 11.25 23 105677 40941 64352091
Upper respiratory tract infection 19.48 11.25 58 105642 72727 64320305
Vision blurred 19.43 11.25 79 105621 90237 64302795
Polyneuropathy 19.27 11.25 74 105626 19820 64373212
Psychotic disorder 19.21 11.25 17 105683 34561 64358471
Renal cyst haemorrhage 19.20 11.25 11 105689 451 64392581
Mouth ulceration 19.19 11.25 15 105685 32429 64360603
Throat tightness 19.13 11.25 7 105693 23153 64369879
Costal cartilage fracture 19.05 11.25 9 105691 246 64392786
Acne 19.02 11.25 7 105693 23074 64369958
Disease progression 18.96 11.25 145 105555 141535 64251497
Hypertensive heart disease 18.81 11.25 27 105673 3777 64389255
Hepatic cyst 18.68 11.25 32 105668 5208 64387824
Periarthritis calcarea 18.67 11.25 6 105694 55 64392977
Pulmonary mass 18.62 11.25 8 105692 24008 64369024
Akinesia 18.48 11.25 24 105676 3055 64389977
Thirst decreased 18.43 11.25 9 105691 265 64392767
Neuroleptic malignant syndrome 18.33 11.25 9 105691 24987 64368045
Palpitations 18.22 11.25 256 105444 104232 64288800
Therapeutic drug monitoring analysis incorrectly performed 18.20 11.25 8 105692 184 64392848
Biopsy skin abnormal 18.16 11.25 8 105692 185 64392847
Small intestinal obstruction 18.04 11.25 8 105692 23565 64369467
Anaphylactic shock 17.97 11.25 14 105686 30314 64362718
Activated partial thromboplastin time prolonged 17.96 11.25 54 105646 12777 64380255
Knee arthroplasty 17.94 11.25 11 105689 26988 64366044
Encephalopathy 17.90 11.25 44 105656 58775 64334257
Congenital coronary artery malformation 17.69 11.25 6 105694 66 64392966
Lymphadenopathy 17.51 11.25 31 105669 46655 64346377
Pulpitis dental 17.44 11.25 14 105686 1005 64392027
Swelling face 17.43 11.25 45 105655 59121 64333911
Thoracic haemorrhage 17.19 11.25 8 105692 211 64392821
Erythema 17.16 11.25 210 105490 186860 64206172
Pleurothotonus 17.13 11.25 20 105680 2282 64390750
Hot flush 17.07 11.25 31 105669 46204 64346828
Jaundice 17.07 11.25 137 105563 48375 64344657
Aggression 17.07 11.25 31 105669 46201 64346831
Ear pain 17.04 11.25 10 105690 25126 64367906
Eye pain 17.03 11.25 16 105684 31609 64361423
Colitis 17.00 11.25 45 105655 58629 64334403
Blood glucose abnormal 16.97 11.25 42 105658 8871 64384161
Disease recurrence 16.90 11.25 16 105684 31494 64361538
Dystonia 16.81 11.25 5 105695 18860 64374172
Drug dependence 16.63 11.25 18 105682 33294 64359738
Pneumothorax traumatic 16.62 11.25 8 105692 228 64392804
Intraductal papillary mucinous neoplasm 16.60 11.25 11 105689 586 64392446
Haemothorax 16.52 11.25 29 105671 4813 64388219
Withdrawal syndrome 16.42 11.25 9 105691 23483 64369549
Diabetic nephropathy 16.42 11.25 21 105679 2633 64390399
Ear infection 16.31 11.25 9 105691 23395 64369637
Femoral artery dissection 16.27 11.25 5 105695 39 64392993
Non-compaction cardiomyopathy 16.27 11.25 5 105695 39 64392993
Hepatorenal syndrome 16.25 11.25 25 105675 3721 64389311
Left ventricular hypertrophy 16.24 11.25 43 105657 9463 64383569
Systolic dysfunction 16.24 11.25 23 105677 3179 64389853
Adrenal cyst 16.19 11.25 6 105694 87 64392945
Incorrect route of product administration 16.18 11.25 9 105691 23289 64369743
Insulin autoimmune syndrome 16.14 11.25 9 105691 350 64392682
Activated partial thromboplastin time shortened 16.08 11.25 12 105688 773 64392259
Paraparesis 16.08 11.25 24 105676 3478 64389554
Ventricular extrasystoles 16.00 11.25 64 105636 17465 64375567
COVID-19 15.96 11.25 54 105646 65086 64327946
Gastritis 15.91 11.25 122 105578 42496 64350536
Dyskinesia 15.84 11.25 25 105675 39363 64353669
Accidental exposure to product 15.84 11.25 12 105688 26352 64366680
Articular calcification 15.77 11.25 6 105694 94 64392938
Skin turgor decreased 15.76 11.25 11 105689 638 64392394
Aortic valve sclerosis 15.74 11.25 16 105684 1563 64391469
Spinal pain 15.72 11.25 51 105649 12570 64380462
Adrenomegaly 15.68 11.25 9 105691 370 64392662
Hypertensive emergency 15.66 11.25 19 105681 2257 64390775
Mucosal haemorrhage 15.63 11.25 19 105681 2262 64390770
Chest wall haematoma 15.60 11.25 9 105691 374 64392658
Peripheral venous disease 15.54 11.25 33 105667 6305 64386727
Dry gangrene 15.51 11.25 12 105688 816 64392216
Musculoskeletal disorder 15.50 11.25 5 105695 17901 64375131
Hip fracture 15.44 11.25 13 105687 27086 64365946
Painful respiration 15.43 11.25 22 105678 3059 64389973
Drug reaction with eosinophilia and systemic symptoms 15.39 11.25 42 105658 54175 64338857
Wrong product administered 15.36 11.25 37 105663 7683 64385349
Tendonitis 15.34 11.25 7 105693 20275 64372757
Skin infection 15.33 11.25 3 105697 15034 64377998
Crying 15.09 11.25 7 105693 20083 64372949
Vitamin B6 deficiency 15.04 11.25 8 105692 283 64392749
Diastolic dysfunction 15.02 11.25 40 105660 8835 64384197
Ventricular assist device insertion 14.99 11.25 5 105695 52 64392980
Respiratory depression 14.96 11.25 10 105690 23433 64369599
Pancreatitis 14.89 11.25 49 105651 59558 64333474
Immunodeficiency 14.87 11.25 4 105696 16120 64376912
Antidiuretic hormone abnormality 14.83 11.25 5 105695 54 64392978
Injection site haemorrhage 14.65 11.25 11 105689 24267 64368765
Presyncope 14.55 11.25 103 105597 34986 64358046
Language disorder 14.50 11.25 20 105680 2697 64390335
Dysdiadochokinesis 14.39 11.25 8 105692 309 64392723
Tinnitus 14.37 11.25 21 105679 34112 64358920
Normochromic normocytic anaemia 14.33 11.25 33 105667 6657 64386375
Alanine aminotransferase decreased 14.20 11.25 14 105686 1318 64391714
Body temperature decreased 14.10 11.25 13 105687 25915 64367117
Left ventricular dysfunction 13.98 11.25 60 105640 16894 64376138
Sinus arrest 13.94 11.25 21 105679 3069 64389963
Potentiating drug interaction 13.91 11.25 36 105664 7816 64385216
Catheterisation cardiac 13.88 11.25 27 105673 4846 64388186
Road traffic accident 13.86 11.25 18 105682 30727 64362305
Hypertensive crisis 13.85 11.25 63 105637 18185 64374847
Hepatic cirrhosis 13.85 11.25 82 105618 26216 64366816
Subdural haematoma 13.84 11.25 86 105614 27968 64365064
Pneumocystis jirovecii pneumonia 13.72 11.25 15 105685 27619 64365413
Immature granulocyte count increased 13.62 11.25 9 105691 477 64392555
Aortic dilatation 13.59 11.25 14 105686 1389 64391643
Basal ganglia haemorrhage 13.57 11.25 14 105686 1392 64391640
Hepatitis E antibody positive 13.49 11.25 6 105694 142 64392890
Benign gastrointestinal neoplasm 13.45 11.25 6 105694 143 64392889
Antineutrophil cytoplasmic antibody positive 13.41 11.25 12 105688 1000 64392032
Mental impairment 13.39 11.25 5 105695 16338 64376694
Red blood cell sedimentation rate increased 13.36 11.25 19 105681 31216 64361816
Spinal cord injury cauda equina 13.34 11.25 6 105694 146 64392886
Cardiac pacemaker insertion 13.31 11.25 27 105673 4996 64388036
Mood swings 13.25 11.25 6 105694 17462 64375570
Inflammatory marker increased 13.21 11.25 37 105663 8414 64384618
Blood pressure systolic decreased 13.19 11.25 38 105662 8782 64384250
Transplant rejection 13.17 11.25 6 105694 17395 64375637
Dementia 13.11 11.25 68 105632 20698 64372334
Injection site warmth 13.08 11.25 3 105697 13459 64379573
Anticoagulation drug level increased 13.07 11.25 10 105690 669 64392363
Adverse drug reaction 13.07 11.25 35 105665 45429 64347603
Urogenital haemorrhage 13.06 11.25 10 105690 670 64392362
Atrial tachycardia 13.04 11.25 22 105678 3537 64389495
Photophobia 13.03 11.25 6 105694 17287 64375745
Bladder tamponade 12.96 11.25 9 105691 518 64392514
Genitourinary tract infection 12.92 11.25 7 105693 257 64392775
Apnoea 12.87 11.25 42 105658 10380 64382652
Subclavian artery occlusion 12.87 11.25 6 105694 159 64392873
Psychomotor retardation 12.86 11.25 27 105673 5116 64387916
Overdose 12.85 11.25 184 105516 159382 64233650
Contusion 12.83 11.25 122 105578 113843 64279189
Parotitis 12.82 11.25 17 105683 2208 64390824
Delayed graft function 12.80 11.25 20 105680 3016 64390016
Nephrogenic anaemia 12.78 11.25 21 105679 3304 64389728
Bicytopenia 12.76 11.25 22 105678 3600 64389432
Intestinal haemorrhage 12.71 11.25 28 105672 5486 64387546
Hepatitis E virus test positive 12.66 11.25 6 105694 165 64392867
Tremor 12.63 11.25 169 105531 148061 64244971
Amnesia 12.53 11.25 39 105661 48230 64344802
Tuberculosis 12.48 11.25 3 105697 13035 64379997
Hip arthroplasty 12.47 11.25 10 105690 21341 64371691
Cerebral ventricular rupture 12.31 11.25 8 105692 412 64392620
Urogenital infection bacterial 12.30 11.25 5 105695 94 64392938
Nocturnal dyspnoea 12.30 11.25 13 105687 1329 64391703
Cerebral haemorrhage 12.29 11.25 133 105567 50957 64342075
International normalised ratio abnormal 12.26 11.25 26 105674 4962 64388070
Product substitution issue 12.26 11.25 7 105693 17854 64375178
Middle insomnia 12.25 11.25 3 105697 12874 64380158
Cardiac murmur functional 12.23 11.25 4 105696 39 64392993
Diet noncompliance 12.23 11.25 8 105692 417 64392615
Somatosensory evoked potentials abnormal 12.15 11.25 6 105694 181 64392851
Immobile 12.15 11.25 29 105671 5986 64387046
Eye disorder 12.11 11.25 8 105692 18861 64374171
Nervous system disorder 12.05 11.25 12 105688 23066 64369966
Uveitis 12.02 11.25 3 105697 12705 64380327
Cerebral arteriosclerosis 12.00 11.25 10 105690 757 64392275
Heart rate decreased 11.95 11.25 48 105652 55019 64338013
Acute left ventricular failure 11.94 11.25 13 105687 1374 64391658
Acute respiratory distress syndrome 11.94 11.25 29 105671 38906 64354126
Cardiomegaly 11.93 11.25 73 105627 23611 64369421
Prerenal failure 11.92 11.25 20 105680 3202 64389830
Impaired work ability 11.91 11.25 5 105695 15214 64377818
Product quality issue 11.90 11.25 19 105681 29780 64363252
Hanging 11.84 11.25 5 105695 104 64392928
Paranoia 11.82 11.25 6 105694 16346 64376686
Toothache 11.76 11.25 7 105693 17452 64375580
Sleep disorder 11.76 11.25 54 105646 59655 64333377
Myelosuppression 11.76 11.25 13 105687 23817 64369215
Respiratory distress 11.75 11.25 45 105655 52286 64340746
Sensorimotor disorder 11.71 11.25 10 105690 783 64392249
Immune reconstitution inflammatory syndrome 11.68 11.25 3 105697 12467 64380565
Cardiopulmonary failure 11.67 11.25 29 105671 6141 64386891
Renal atrophy 11.63 11.25 14 105686 1650 64391382
No adverse event 11.61 11.25 18 105682 28543 64364489
Peripheral artery stenosis 11.60 11.25 12 105688 1197 64391835
Metamyelocyte count increased 11.53 11.25 9 105691 620 64392412
Mycobacterium fortuitum infection 11.44 11.25 6 105694 206 64392826
Right hemisphere deficit syndrome 11.44 11.25 3 105697 12 64393020
Breast discomfort 11.41 11.25 7 105693 326 64392706
Accidental overdose 11.39 11.25 94 105606 33463 64359569
Appendicitis 11.38 11.25 4 105696 13565 64379467
Gamma-glutamyltransferase abnormal 11.36 11.25 8 105692 471 64392561
Catheter management 11.33 11.25 20 105680 3335 64389697
Cerebral ischaemia 11.29 11.25 39 105661 9923 64383109
Blood folate increased 11.27 11.25 8 105692 477 64392555
Red cell distribution width abnormal 11.26 11.25 6 105694 213 64392819
Breast cancer 11.26 11.25 19 105681 29129 64363903

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03CA04 CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Sulfonamides, plain
FDA PE N0000175366 Increased Diuresis at Loop of Henle
FDA EPC N0000175590 Loop Diuretic
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004232 Diuretics
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D045283 Natriuretic Agents
MeSH PA D049994 Sodium Potassium Chloride Symporter Inhibitors
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:77608 loop diuretics

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Decompensated cardiac failure indication 195111005
Edema indication 267038008
Pulmonary Edema due to Chronic Heart Failure indication
Peripheral Edema due to Chronic Heart Failure indication
Renal Disease with Edema indication
Edema due to Hepatic Cirrhosis indication
Metabolic alkalosis contraindication 1388004
Anuria contraindication 2472002 DOID:2983
Cirrhosis of liver contraindication 19943007 DOID:5082
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Gout contraindication 90560007 DOID:13189
Hearing disorder contraindication 128540005
Hypertriglyceridemia contraindication 302870006
Ascites contraindication 389026000
Azotemia contraindication 445009001




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.25 acidic
pKa2 6.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Solute carrier family 12 member 1 Transporter INHIBITOR IC50 6.40 WOMBAT-PK CHEMBL

External reference:

IDSource
4020851 VUID
N0000148359 NUI
D00382 KEGG_DRUG
4020851 VANDF
C0076840 UMLSCUI
CHEBI:9637 CHEBI
CHEMBL1148 ChEMBL_ID
DB00214 DRUGBANK_ID
D000077786 MESH_DESCRIPTOR_UI
41781 PUBCHEM_CID
7312 IUPHAR_LIGAND_ID
3938 INN_ID
W31X2H97FB UNII
38413 RXNORM
43738 MMSL
5604 MMSL
d03189 MMSL
004414 NDDF
108476002 SNOMEDCT_US
318034005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-0077 TABLET 20 mg ORAL ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0517-0770 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0517-0771 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-5575 TABLET 20 mg ORAL ANDA 23 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7997 TABLET 20 mg ORAL ANDA 23 sections
Torsemide Human Prescription Drug Label 1 31722-529 TABLET 5 mg ORAL ANDA 24 sections
Torsemide Human Prescription Drug Label 1 31722-530 TABLET 10 mg ORAL ANDA 24 sections
Torsemide Human Prescription Drug Label 1 31722-531 TABLET 20 mg ORAL ANDA 24 sections
Torsemide Human Prescription Drug Label 1 31722-532 TABLET 100 mg ORAL ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-816 TABLET 5 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-817 TABLET 10 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-818 TABLET 20 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-819 TABLET 100 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 43353-315 TABLET 20 mg ORAL ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50111-915 TABLET 5 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50111-916 TABLET 10 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50111-917 TABLET 20 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50111-918 TABLET 100 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50268-754 TABLET 5 mg ORAL ANDA 18 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50268-754 TABLET 5 mg ORAL ANDA 18 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50268-755 TABLET 10 mg ORAL ANDA 18 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50268-755 TABLET 10 mg ORAL ANDA 18 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50268-756 TABLET 20 mg ORAL ANDA 18 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50268-756 TABLET 20 mg ORAL ANDA 18 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50268-757 TABLET 100 mg ORAL ANDA 18 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50268-757 TABLET 100 mg ORAL ANDA 18 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 51407-362 TABLET 20 mg ORAL ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 54868-1234 TABLET 100 mg ORAL ANDA 11 sections
Demadex HUMAN PRESCRIPTION DRUG LABEL 1 54868-3835 TABLET 10 mg ORAL NDA 12 sections
Demadex HUMAN PRESCRIPTION DRUG LABEL 1 54868-4687 TABLET 20 mg ORAL NDA 12 sections