torsemide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diuretics, furosemide derivatives	2708	56211-40-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: torasemide torsemide toradiur	A pyridine and sulfonamide derivative that acts as a sodium-potassium chloride symporter inhibitor (loop diuretic). It is used for the treatment of EDEMA associated with CONGESTIVE HEART FAILURE; CHRONIC RENAL INSUFFICIENCY; and LIVER DISEASES. It is also used for the management of HYPERTENSION. Molecular weight: 348.42 Formula: C16H20N4O3S CLOGP: 3.21 LIPINSKI: 0 HAC: 7 HDO: 3 TPSA: 100.19 ALOGS: -3.77 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

torasemide
torsemide
toradiur

A pyridine and sulfonamide derivative that acts as a sodium-potassium chloride symporter inhibitor (loop diuretic). It is used for the treatment of EDEMA associated with CONGESTIVE HEART FAILURE; CHRONIC RENAL INSUFFICIENCY; and LIVER DISEASES. It is also used for the management of HYPERTENSION.

Molecular weight: 348.42
Formula: C16H20N4O3S
CLOGP: 3.21
LIPINSKI: 0
HAC: 7
HDO: 3
TPSA: 100.19
ALOGS: -3.77
ROTB: 4

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
15	mg	O
15	mg	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.16 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	20 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	9.56 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	91 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.21 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.53 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.01 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	5.10 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Aug. 23, 1993	FDA	MEDA PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	1792.17	12.46	1599	68467	199803	63219153
Product prescribing error	1008.62	12.46	519	69547	25770	63393186
Product monitoring error	825.39	12.46	273	69793	4243	63414713
Haematochezia	656.26	12.46	513	69553	53031	63365925
Cardiac failure	608.80	12.46	613	69453	88529	63330427
Drug ineffective	548.71	12.46	236	69830	1044529	62374427
Renal impairment	474.63	12.46	535	69531	87820	63331136
Dyspnoea	451.15	12.46	1673	68393	659640	62759316
Oedema peripheral	434.55	12.46	762	69304	188749	63230207
Labelled drug-drug interaction medication error	430.11	12.46	235	69831	13164	63405792
Systemic infection	426.54	12.46	169	69897	4491	63414465
Acute kidney injury	421.90	12.46	910	69156	262505	63156451
Anaemia	411.09	12.46	961	69105	292469	63126487
Dehydration	296.92	12.46	616	69450	172738	63246218
Atrial fibrillation	291.99	12.46	488	69578	116148	63302808
Syncope	238.13	12.46	448	69618	116937	63302019
Fall	222.73	12.46	939	69127	391395	63027561
Joint swelling	221.48	12.46	46	70020	327620	63091336
Bradycardia	216.97	12.46	331	69735	72896	63346060
Electrolyte imbalance	215.23	12.46	178	69888	19898	63399058
Rash	214.34	12.46	183	69883	560688	62858268
Hyponatraemia	213.34	12.46	416	69650	111484	63307472
Therapeutic drug monitoring analysis not performed	212.52	12.46	73	69993	1279	63417677
Arthropathy	210.68	12.46	12	70054	234780	63184176
Drug intolerance	205.18	12.46	45	70021	308616	63110340
Drug interaction	200.83	12.46	632	69434	228499	63190457
Arrhythmia	194.49	12.46	225	69841	37915	63381041
Off label use	193.11	12.46	279	69787	674183	62744773
Treatment failure	192.39	12.46	6	70060	199037	63219919
Drug hypersensitivity	189.66	12.46	54	70012	310633	63108323
Synovitis	186.80	12.46	4	70062	186914	63232042
Systemic lupus erythematosus	186.44	12.46	11	70055	208907	63210049
Hypotension	183.87	12.46	689	69377	271915	63147041
Infusion related reaction	182.12	12.46	27	70039	245494	63173462
Haematemesis	180.11	12.46	194	69872	30218	63388738
Pulmonary arterial hypertension	170.09	12.46	164	69902	22413	63396543
Therapeutic product effect decreased	169.88	12.46	11	70055	193176	63225780
Hyperkalaemia	166.18	12.46	249	69817	53954	63365002
Alopecia	165.49	12.46	83	69983	337453	63081503
Hypersensitivity	162.50	12.46	60	70006	292625	63126331
Hypokalaemia	159.23	12.46	353	69713	103451	63315505
Orthostatic intolerance	151.43	12.46	55	70011	1142	63417814
Blood creatinine increased	149.96	12.46	312	69754	87532	63331424
Dyspnoea exertional	146.35	12.46	249	69817	60053	63358903
Discomfort	145.77	12.46	10	70056	167364	63251592
Fluid retention	140.30	12.46	243	69823	59443	63359513
Rheumatoid arthritis	137.58	12.46	54	70012	253765	63165191
Pallor	132.38	12.46	166	69900	30402	63388554
Abdominal discomfort	129.41	12.46	99	69967	320786	63098170
Lower respiratory tract infection	127.77	12.46	4	70062	132303	63286653
Renal failure	125.27	12.46	348	69718	117304	63301652
Product administration error	124.14	12.46	138	69928	22259	63396697
Swelling	118.83	12.46	79	69987	275299	63143657
Dizziness	117.56	12.46	844	69222	429081	62989875
Anuria	117.56	12.46	103	69963	12448	63406508
Pain	114.86	12.46	426	69640	740202	62678754
Maternal exposure during pregnancy	112.53	12.46	51	70015	220011	63198945
Arthralgia	112.06	12.46	294	69772	569416	62849540
Melaena	109.93	12.46	151	69915	30214	63388742
Glomerular filtration rate decreased	109.55	12.46	102	69964	13339	63405617
Angina pectoris	108.03	12.46	149	69917	29929	63389027
Musculoskeletal stiffness	107.29	12.46	35	70031	184583	63234373
Gastrointestinal haemorrhage	106.82	12.46	260	69806	80916	63338040
Cardiac failure chronic	105.68	12.46	64	70002	4354	63414602
Haematoma	105.33	12.46	159	69907	34661	63384295
Hypervolaemia	103.92	12.46	142	69924	28271	63390685
Pericarditis	103.42	12.46	12	70054	131567	63287389
Right ventricular failure	102.38	12.46	110	69956	17078	63401878
Product use issue	101.00	12.46	59	70007	220461	63198495
Lactic acidosis	99.42	12.46	163	69903	38124	63380832
Tachypnoea	98.29	12.46	108	69958	17194	63401762
Pulmonary hypertension	97.69	12.46	159	69907	36964	63381992
Electrocardiogram abnormal	95.49	12.46	80	69986	9099	63409857
Completed suicide	95.15	12.46	22	70044	145651	63273305
Tachycardia	94.36	12.46	316	69750	117840	63301116
Sinusitis	91.22	12.46	70	69996	226583	63192373
Hyperglycaemia	87.53	12.46	162	69904	41705	63377251
Hepatic enzyme increased	85.96	12.46	59	70007	202269	63216687
Pancreatic steatosis	79.74	12.46	33	70033	983	63417973
Helicobacter infection	79.44	12.46	6	70060	92779	63326177
Atrial flutter	75.51	12.46	72	69994	9700	63409256
Injection site pain	74.70	12.46	25	70041	129775	63289181
Aortic valve stenosis	74.33	12.46	46	70020	3253	63415703
Therapeutic product effect incomplete	72.12	12.46	24	70042	125032	63293924
Irritable bowel syndrome	71.50	12.46	5	70061	82407	63336549
Mitral valve incompetence	70.25	12.46	97	69969	19497	63399459
Upper gastrointestinal haemorrhage	70.12	12.46	95	69971	18757	63400199
Haemoglobin decreased	69.96	12.46	332	69734	145153	63273803
Nasopharyngitis	69.69	12.46	108	69958	254149	63164807
Exposure during pregnancy	69.25	12.46	43	70023	155504	63263452
Contraindicated product administered	68.12	12.46	84	69982	217564	63201392
Intentional product use issue	67.94	12.46	28	70038	127864	63291092
Tricuspid valve incompetence	67.47	12.46	82	69984	14539	63404417
Blood loss anaemia	67.06	12.46	65	70001	8936	63410020
Tachyarrhythmia	66.35	12.46	48	70018	4402	63414554
Disorientation	65.96	12.46	139	69927	39313	63379643
Urticaria	65.68	12.46	52	70014	165750	63253206
Pleural effusion	65.48	12.46	239	69827	92971	63325985
Chronic kidney disease	64.66	12.46	150	69916	45248	63373708
Blood urea increased	62.74	12.46	108	69958	26271	63392685
Psoriatic arthropathy	61.40	12.46	13	70053	91507	63327449
N-terminal prohormone brain natriuretic peptide increased	58.74	12.46	34	70032	2127	63416829
Femoral hernia incarcerated	58.27	12.46	25	70041	816	63418140
Peripheral circulatory failure	58.07	12.46	26	70040	942	63418014
Medication error	57.93	12.46	157	69909	52127	63366829
Polyneuropathy	56.52	12.46	75	69991	14514	63404442
Hypoglycaemia	56.47	12.46	170	69896	59895	63359061
Blood uric acid increased	56.29	12.46	47	70019	5320	63413636
Cardiac failure congestive	55.10	12.46	225	69841	92208	63326748
Diverticulum intestinal	54.81	12.46	51	70015	6662	63412294
Arterial haemorrhage	54.76	12.46	30	70036	1687	63417269
Blood cholesterol increased	54.29	12.46	18	70048	94014	63324942
Restlessness	54.23	12.46	108	69958	29345	63389611
Stomatitis	53.08	12.46	45	70021	138680	63280276
Arthritis	53.05	12.46	31	70035	115890	63303066
Cardiogenic shock	52.97	12.46	81	69985	17851	63401105
Gastroenteritis clostridial	52.53	12.46	21	70045	571	63418385
Gastrointestinal disorder	50.92	12.46	42	70024	131197	63287759
Malaise	50.39	12.46	262	69804	415692	63003264
Lymphatic fistula	50.00	12.46	22	70044	764	63418192
Cardiac failure acute	49.90	12.46	57	70009	9466	63409490
Eructation	49.04	12.46	53	70013	8280	63410676
Fibromyalgia	48.94	12.46	14	70052	80406	63338550
Peripheral arterial occlusive disease	48.70	12.46	39	70027	4162	63414794
Blister	48.58	12.46	43	70023	129771	63289185
Limb reduction defect	48.08	12.46	18	70048	408	63418548
Loss of personal independence in daily activities	47.46	12.46	24	70042	97266	63321690
Circulatory collapse	47.25	12.46	86	69980	21852	63397104
Ascites	46.83	12.46	124	69942	40604	63378352
Migraine	46.78	12.46	28	70038	103318	63315638
Waist circumference increased	46.51	12.46	22	70044	906	63418050
Dementia	46.08	12.46	78	69988	18716	63400240
Hypertensive crisis	45.08	12.46	69	69997	15217	63403739
Back pain	44.71	12.46	146	69920	263999	63154957
Injection site reaction	44.35	12.46	6	70060	58518	63360438
Dysuria	43.22	12.46	107	69959	33631	63385325
Hyperthyroidism	42.95	12.46	66	70000	14607	63404349
Renal function test abnormal	42.53	12.46	34	70032	3619	63415337
Fracture	42.47	12.46	77	69989	19507	63399449
Haematuria	42.24	12.46	97	69969	29060	63389896
Product use in unapproved indication	41.85	12.46	84	69982	178996	63239960
Flatulence	41.27	12.46	107	69959	34595	63384361
Abdominal pain lower	41.22	12.46	89	69977	25589	63393367
Pruritus	40.82	12.46	233	69833	361220	63057736
Gamma-glutamyltransferase increased	40.54	12.46	105	69961	33926	63385030
Therapeutic drug monitoring analysis incorrectly performed	40.53	12.46	15	70051	329	63418627
Coagulation test abnormal	40.24	12.46	19	70047	779	63418177
Hypoaesthesia	40.20	12.46	78	69988	168315	63250641
Drug abuse	39.95	12.46	15	70051	72503	63346453
Adverse drug reaction	39.89	12.46	19	70047	79695	63339261
Erysipelas	39.21	12.46	46	70020	7859	63411097
Wound infection pseudomonas	39.06	12.46	22	70044	1306	63417650
Rhonchi	38.89	12.46	28	70038	2548	63416408
Mobility decreased	38.68	12.46	46	70020	121113	63297843
Oedema	38.64	12.46	211	69855	97411	63321545
Acute respiratory failure	38.64	12.46	104	69962	34381	63384575
Blood potassium increased	38.45	12.46	71	69995	18238	63400718
Retrograde amnesia	38.43	12.46	16	70050	484	63418472
Haemarthrosis	38.05	12.46	30	70036	3131	63415825
Toxicity to various agents	37.59	12.46	143	69923	247107	63171849
Faecaloma	37.40	12.46	45	70021	7896	63411060
Respiratory failure	36.91	12.46	215	69851	101643	63317313
Vascular resistance pulmonary decreased	36.90	12.46	10	70056	74	63418882
Coronary artery disease	36.64	12.46	98	69968	32279	63386677
Accidental overdose	36.51	12.46	80	69986	23229	63395727
Left-to-right cardiac shunt	36.39	12.46	11	70055	125	63418831
Paraesthesia	36.36	12.46	74	69992	156892	63262064
Anaphylactic reaction	35.86	12.46	14	70052	66086	63352870
Stasis dermatitis	35.71	12.46	17	70049	710	63418246
Insomnia	35.70	12.46	120	69946	215132	63203824
Limb hypoplasia congenital	35.65	12.46	12	70054	197	63418759
Injection site erythema	35.63	12.46	24	70042	83150	63335806
Coronavirus test positive	35.32	12.46	17	70049	728	63418228
Prothrombin time prolonged	35.27	12.46	48	70018	9516	63409440
Psoriasis	34.76	12.46	27	70039	86930	63332026
Wound	34.49	12.46	81	69985	163182	63255774
C-reactive protein abnormal	34.29	12.46	5	70061	46091	63372865
Internal haemorrhage	34.23	12.46	35	70031	5130	63413826
Liver injury	34.21	12.46	12	70054	60508	63358448
Seroma	34.11	12.46	24	70042	2107	63416849
Glomerular filtration rate abnormal	33.40	12.46	17	70049	822	63418134
Left ventricular failure	33.17	12.46	36	70030	5651	63413305
Urosepsis	32.99	12.46	67	69999	18457	63400499
Injury	32.93	12.46	20	70046	73227	63345729
Atrioventricular block complete	32.86	12.46	43	70023	8208	63410748
Thirst	32.75	12.46	57	70009	13984	63404972
Crush syndrome	32.66	12.46	10	70056	119	63418837
Hepatic cyst	32.49	12.46	34	70032	5120	63413836
Exercise tolerance decreased	32.41	12.46	35	70031	5462	63413494
Knee arthroplasty	31.95	12.46	10	70056	54196	63364760
Congenital oral malformation	31.85	12.46	11	70055	196	63418760
Depressed level of consciousness	31.52	12.46	144	69922	61934	63357022
Headache	31.38	12.46	501	69565	632740	62786216
Congenital coronary artery malformation	31.31	12.46	10	70056	138	63418818
Concomitant disease aggravated	31.01	12.46	44	70022	9068	63409888
Product used for unknown indication	30.99	12.46	14	70052	518	63418438
Diverticulum intestinal haemorrhagic	30.76	12.46	20	70046	1541	63417415
Ill-defined disorder	30.68	12.46	27	70039	81728	63337228
Spinal pain	30.21	12.46	53	70013	13086	63405870
Joint stiffness	30.10	12.46	5	70061	41864	63377092
Febrile neutropenia	29.92	12.46	53	70013	118396	63300560
Cardiorenal syndrome	29.89	12.46	16	70050	859	63418097
Cholestatic liver injury	29.77	12.46	24	70042	2586	63416370
Bradyarrhythmia	29.69	12.46	22	70044	2093	63416863
Depression	29.62	12.46	114	69952	196378	63222578
Transfusion	29.46	12.46	57	70009	15160	63403796
Device stimulation issue	29.43	12.46	8	70058	60	63418896
Spontaneous haemorrhage	29.40	12.46	14	70052	585	63418371
Epistaxis	29.32	12.46	158	69908	72567	63346389
Tooth erosion	29.32	12.46	13	70053	460	63418496
Psychomotor retardation	28.93	12.46	28	70038	3842	63415114
Polyuria	28.70	12.46	41	70025	8501	63410455
Anxiety	28.61	12.46	133	69933	217408	63201548
Lower gastrointestinal haemorrhage	28.19	12.46	39	70027	7851	63411105
Bundle branch block right	28.04	12.46	31	70035	4967	63413989
Red blood cell sedimentation rate increased	28.00	12.46	7	70059	43975	63374981
Urinary retention	27.76	12.46	85	69981	30216	63388740
Hip arthroplasty	27.71	12.46	9	70057	47637	63371319
Neuropathy peripheral	27.69	12.46	52	70014	113615	63305341
Osteoarthritis	27.54	12.46	39	70027	95304	63323652
Hypotonia	27.50	12.46	42	70024	9243	63409713
Pregnancy	27.39	12.46	4	70062	36832	63382124
Therapeutic response decreased	27.38	12.46	17	70049	61508	63357448
Sudden cardiac death	27.25	12.46	21	70045	2119	63416837
Pericardial effusion	27.24	12.46	84	69982	29974	63388982
Constipation	27.23	12.46	373	69693	224570	63194386
Cerebral haemorrhage	27.04	12.46	85	69981	30644	63388312
Administration site discomfort	26.87	12.46	8	70058	86	63418870
N-terminal prohormone brain natriuretic peptide abnormal	26.69	12.46	7	70059	45	63418911
Ear pain	26.67	12.46	4	70062	36114	63382842
Abdominal pain	26.48	12.46	463	69603	292993	63125963
Labelled drug-drug interaction issue	26.46	12.46	16	70050	1085	63417871
Pulmonary congestion	26.40	12.46	59	70007	17359	63401597
Cardiovascular disorder	26.32	12.46	47	70019	11765	63407191
Injection site bruising	26.05	12.46	7	70059	41903	63377053
Sleep disorder	26.00	12.46	31	70035	81535	63337421
Biopsy skin abnormal	25.99	12.46	8	70058	97	63418859
Oropharyngeal pain	25.98	12.46	40	70026	94447	63324509
Orthopnoea	25.51	12.46	33	70033	6228	63412728
Pulmonary oedema	25.46	12.46	124	69942	54749	63364207
Injection site pruritus	25.41	12.46	9	70057	45107	63373849
Thrombin time prolonged	25.28	12.46	8	70058	107	63418849
Hypothermia	25.24	12.46	50	70016	13531	63405425
Parkinsonism	25.16	12.46	43	70023	10396	63408560
Hypertensive emergency	25.14	12.46	19	70047	1863	63417093
Cleft palate	25.08	12.46	15	70051	997	63417959
Escherichia infection	24.97	12.46	48	70018	12706	63406250
Skin haemorrhage	24.89	12.46	42	70024	10052	63408904
Condition aggravated	24.88	12.46	600	69466	401617	63017339
Multiple drug therapy	24.69	12.46	25	70041	3621	63415335
Cardioversion	24.48	12.46	16	70050	1244	63417712
Painful respiration	24.45	12.46	22	70044	2752	63416204
Musculoskeletal pain	24.41	12.46	180	69886	92097	63326859
Therapy non-responder	24.03	12.46	29	70037	75872	63343084
Sprue-like enteropathy	23.75	12.46	13	70053	730	63418226
Feeling abnormal	23.73	12.46	84	69982	148308	63270648
Glycosylated haemoglobin increased	23.47	12.46	46	70020	12352	63406604
Adverse event	23.37	12.46	24	70042	67535	63351421
Contusion	23.29	12.46	86	69980	149958	63268998
Femoral artery dissection	23.23	12.46	6	70060	36	63418920
Fracture blisters	23.20	12.46	7	70059	79	63418877
Infection	23.09	12.46	153	69913	229020	63189936
Haemorrhagic erosive gastritis	23.05	12.46	11	70055	462	63418494
Decreased appetite	22.97	12.46	397	69669	250655	63168301
Suicidal ideation	22.96	12.46	21	70045	62400	63356556
Neuroglycopenia	22.94	12.46	11	70055	467	63418489
Antineutrophil cytoplasmic antibody positive	22.88	12.46	12	70054	618	63418338
Injection site swelling	22.80	12.46	12	70054	47560	63371396
Aortic arteriosclerosis	22.65	12.46	31	70035	6178	63412778
Asthma	22.61	12.46	69	69997	127492	63291464
Aplastic anaemia	22.52	12.46	39	70027	9530	63409426
Pneumothorax traumatic	22.40	12.46	8	70058	158	63418798
Abdominal distension	22.36	12.46	168	69898	86447	63332509
Cerebral ischaemia	22.18	12.46	32	70034	6696	63412260
Pelvic venous thrombosis	21.87	12.46	17	70049	1738	63417218
Type 2 diabetes mellitus	21.74	12.46	23	70043	63845	63355111
International normalised ratio increased	21.60	12.46	105	69961	46320	63372636
Catheterisation cardiac	21.54	12.46	26	70040	4577	63414379
Thirst decreased	21.53	12.46	9	70057	275	63418681
Polyserositis	21.48	12.46	10	70056	397	63418559
Pulmonary vein occlusion	21.44	12.46	7	70059	104	63418852
Gout	21.30	12.46	46	70020	13225	63405731
Generalised oedema	21.14	12.46	51	70015	15767	63403189
Pulpitis dental	21.06	12.46	13	70053	915	63418041
Coma	21.01	12.46	24	70042	64340	63354616
Helplessness	20.94	12.46	9	70057	295	63418661
Product dose omission issue	20.90	12.46	162	69904	234151	63184805
Gastritis	20.80	12.46	89	69977	37214	63381742
Pain in extremity	20.75	12.46	250	69816	331236	63087720
Multiple sclerosis relapse	20.74	12.46	14	70052	48464	63370492
Dyspnoea at rest	20.67	12.46	24	70042	4055	63414901
Chest wall haematoma	20.56	12.46	8	70058	202	63418754
Retrognathia	20.44	12.46	10	70056	444	63418512
Bicytopenia	20.39	12.46	19	70047	2486	63416470
Inflammatory marker increased	20.35	12.46	31	70035	6808	63412148
Upper respiratory tract irritation	20.24	12.46	8	70058	211	63418745
Thrombocytopenia	20.09	12.46	255	69811	150902	63268054
Antidiuretic hormone abnormality	19.96	12.46	5	70061	26	63418930
Dysmorphism	19.83	12.46	18	70048	2278	63416678
Sensorimotor disorder	19.79	12.46	10	70056	476	63418480
Inflammation	19.72	12.46	38	70028	82235	63336721
Night sweats	19.70	12.46	15	70051	48799	63370157
Haemoptysis	19.60	12.46	73	69993	28653	63390303
Serotonin syndrome	19.39	12.46	4	70062	28678	63390278
Talipes	19.37	12.46	15	70051	1525	63417431
Lethargy	19.26	12.46	20	70046	55987	63362969
Necrotising fasciitis	19.06	12.46	20	70046	3021	63415935
Sinoatrial block	19.04	12.46	12	70054	876	63418080
Brain natriuretic peptide increased	18.97	12.46	26	70040	5187	63413769
Subdural haematoma	18.94	12.46	46	70020	14282	63404674
Glomerular filtration rate increased	18.92	12.46	12	70054	886	63418070
Stress	18.88	12.46	28	70038	67139	63351817
Diastolic dysfunction	18.79	12.46	29	70037	6442	63412514
Language disorder	18.78	12.46	17	70049	2143	63416813
Upper respiratory tract infection	18.72	12.46	39	70027	82008	63336948
Procalcitonin increased	18.43	12.46	13	70053	1146	63417810
Irritability	18.41	12.46	6	70060	31688	63387268
Blood cholesterol decreased	18.37	12.46	12	70054	932	63418024
Amnesia	17.84	12.46	21	70045	55564	63363392
Throat tightness	17.83	12.46	3	70063	24884	63394072
Hyperparathyroidism secondary	17.82	12.46	14	70052	1453	63417503
Vomiting	17.82	12.46	771	69295	558846	62860110
Ventricular fibrillation	17.76	12.46	40	70026	11827	63407129
White blood cell count decreased	17.71	12.46	86	69980	139018	63279938
Post procedural haematuria	17.69	12.46	5	70061	44	63418912
Drug clearance decreased	17.68	12.46	14	70052	1470	63417486
No adverse event	17.66	12.46	12	70054	41393	63377563
Presyncope	17.64	12.46	69	69997	27716	63391240
Left ventricular dysfunction	17.49	12.46	40	70026	11948	63407008
COVID-19	17.43	12.46	65	70001	113038	63305918
Vascular graft infection	17.39	12.46	5	70061	47	63418909
Cerebral infarction	17.39	12.46	62	70004	23831	63395125
Toxoplasmosis	17.36	12.46	14	70052	1509	63417447
Drug ineffective for unapproved indication	17.22	12.46	8	70058	34055	63384901
Atrial thrombosis	17.18	12.46	15	70051	1803	63417153
Wound dehiscence	17.17	12.46	24	70042	4879	63414077
Gangrene	17.16	12.46	27	70039	6096	63412860
Dry eye	17.14	12.46	12	70054	40749	63378207
Anal haemorrhage	17	12.46	16	70050	2120	63416836
Dry gangrene	16.92	12.46	10	70056	650	63418306
Herbal interaction	16.92	12.46	6	70060	116	63418840
Bursitis	16.81	12.46	10	70056	37031	63381925
End stage renal disease	16.70	12.46	28	70038	6665	63412291
Palpitations	16.61	12.46	194	69872	112576	63306380
Cerebral artery occlusion	16.50	12.46	11	70055	884	63418072
Developmental hip dysplasia	16.47	12.46	13	70053	1359	63417597
Aggression	16.47	12.46	3	70063	23495	63395461
Influenza	16.42	12.46	63	70003	108659	63310297
Hypochromic anaemia	16.33	12.46	15	70051	1927	63417029
Low density lipoprotein abnormal	16.30	12.46	7	70059	229	63418727
Chronic respiratory failure	16.30	12.46	15	70051	1932	63417024
Blindness cortical	16.24	12.46	9	70057	518	63418438
Cyanosis	15.97	12.46	48	70018	16887	63402069
Sciatica	15.95	12.46	9	70057	34315	63384641
Drug resistance	15.92	12.46	3	70063	22930	63396026
Brain natriuretic peptide abnormal	15.85	12.46	8	70058	380	63418576
Sinus arrhythmia	15.66	12.46	13	70053	1460	63417496
HCoV-HKU1 infection	15.63	12.46	4	70062	23	63418933
Nephrolithiasis	15.59	12.46	14	70052	41970	63376986
Red cell distribution width abnormal	15.52	12.46	6	70060	149	63418807
Blood pressure fluctuation	15.41	12.46	17	70049	46300	63372656
Supraventricular extrasystoles	15.38	12.46	22	70044	4567	63414389
Ventricular assist device insertion	15.35	12.46	4	70062	25	63418931
Grip strength decreased	15.29	12.46	3	70063	22284	63396672
Hypertensive heart disease	15.14	12.46	16	70050	2436	63416520
Road traffic accident	15.12	12.46	11	70055	36621	63382335
Influenza like illness	15.04	12.46	32	70034	66792	63352164
Sinus node dysfunction	15.03	12.46	22	70044	4663	63414293
Atrioventricular block first degree	15.01	12.46	28	70038	7245	63411711
Ventricular extrasystoles	14.90	12.46	37	70029	11650	63407306
Vascular encephalopathy	14.88	12.46	8	70058	433	63418523
Blood creatine increased	14.74	12.46	24	70042	5577	63413379
Ecthyma	14.74	12.46	7	70059	291	63418665
Hepatic failure	14.73	12.46	78	69988	35578	63383378
Gastritis erosive	14.72	12.46	25	70041	6014	63412942
Leukopenia	14.69	12.46	140	69926	77150	63341806
Atrial septal defect	14.69	12.46	27	70039	6911	63412045
Accidental exposure to product	14.54	12.46	6	70060	27399	63391557
Sinus rhythm	14.54	12.46	10	70056	846	63418110
Neutrophil count decreased	14.45	12.46	25	70041	56381	63362575
Periodontitis	14.39	12.46	18	70048	3285	63415671
International normalised ratio abnormal	14.39	12.46	18	70048	3286	63415670
Septic encephalopathy	14.38	12.46	5	70061	91	63418865
Ischaemic stroke	14.29	12.46	48	70018	17909	63401047
Hyperuricaemia	14.12	12.46	23	70043	5347	63413609
Blood pressure systolic increased	14.07	12.46	19	70047	47378	63371578
Lymphadenopathy	14.07	12.46	13	70053	38445	63380511
Fungal infection	14.05	12.46	12	70054	36862	63382094
Burning sensation	14.04	12.46	24	70042	54383	63364573
Arteriosclerosis	14.04	12.46	33	70033	10033	63408923
Dyskinesia	14.02	12.46	9	70057	31993	63386963
Rash pruritic	14.00	12.46	28	70038	59771	63359185
Blood pressure decreased	14.00	12.46	121	69945	64901	63354055
Sepsis	13.93	12.46	242	69824	152881	63266075
Nausea	13.86	12.46	1108	68958	853363	62565593
Oral pain	13.85	12.46	7	70059	28387	63390569
Iron deficiency anaemia	13.84	12.46	51	70015	19918	63399038
Leukocytosis	13.79	12.46	61	70005	25874	63393082
Alanine aminotransferase decreased	13.71	12.46	9	70057	705	63418251
Cardiac murmur functional	13.69	12.46	4	70062	40	63418916
Chronic obstructive pulmonary disease	13.68	12.46	117	69949	62569	63356387
Aplasia	13.66	12.46	20	70046	4239	63414717
Rhinorrhoea	13.47	12.46	33	70033	65544	63353412
Muscle spasms	13.43	12.46	109	69957	156041	63262915
Hemiparesis	13.33	12.46	56	70010	23226	63395730
Concomitant disease progression	13.31	12.46	14	70052	2120	63416836
Product quality issue	13.27	12.46	12	70054	35853	63383103
Lip erosion	13.21	12.46	10	70056	983	63417973
Gastritis haemorrhagic	13.12	12.46	12	70054	1533	63417423
Femoral neck fracture	13.06	12.46	29	70037	8494	63410462
Hepatocellular carcinoma	12.99	12.46	14	70052	2180	63416776
Urinary tract infection	12.93	12.46	383	69683	264301	63154655
Neutropenia	12.93	12.46	127	69939	174878	63244078
Alcoholic liver disease	12.90	12.46	5	70061	125	63418831
Right aortic arch	12.89	12.46	6	70060	238	63418718
Atrioventricular block	12.84	12.46	27	70039	7620	63411336
Periorbital haematoma	12.84	12.46	9	70057	785	63418171
Inappropriate schedule of product administration	12.82	12.46	65	70001	103900	63315056
Pulse absent	12.77	12.46	22	70044	5352	63413604
Ear infection	12.74	12.46	14	70052	38199	63380757
Hyperphosphataemia	12.71	12.46	14	70052	2234	63416722
Cardiac pacemaker insertion	12.70	12.46	19	70047	4107	63414849
Acne	12.52	12.46	5	70061	23288	63395668
Ischaemic cerebral infarction	12.51	12.46	11	70055	1335	63417621

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	1672.12	12.06	1636	67941	126633	34760721
Oedema peripheral	670.41	12.06	996	68581	118816	34768538
Cardiac failure	659.15	12.06	858	68719	90390	34796964
Product monitoring error	479.91	12.06	214	69363	4167	34883187
Product prescribing error	450.75	12.06	370	69207	22557	34864797
Haematochezia	428.44	12.06	495	69082	46039	34841315
Dyspnoea	423.10	12.06	1670	67907	375112	34512242
Drug ineffective	326.70	12.06	260	69317	456491	34430863
Systemic infection	321.57	12.06	172	69405	5040	34882314
Anaemia	279.24	12.06	1057	68520	232278	34655076
Cardiac failure chronic	260.60	12.06	174	69403	7705	34879649
Electrocardiogram abnormal	217.66	12.06	166	69411	9081	34878273
Electrolyte imbalance	211.47	12.06	197	69380	14215	34873139
Off label use	210.01	12.06	320	69257	419204	34468150
Atrial fibrillation	193.58	12.06	609	68968	121784	34765570
Syncope	183.95	12.06	496	69081	90955	34796399
Dizziness	182.25	12.06	888	68689	217633	34669721
Renal impairment	181.54	12.06	504	69073	94009	34793345
Toxicity to various agents	178.51	12.06	88	69489	200274	34687080
Dyspnoea exertional	170.92	12.06	308	69269	42971	34844383
Bradycardia	158.66	12.06	416	69161	75002	34812352
Labelled drug-drug interaction medication error	152.79	12.06	168	69409	14771	34872583
N-terminal prohormone brain natriuretic peptide increased	146.45	12.06	82	69495	2633	34884721
Acute kidney injury	136.60	12.06	1055	68522	303933	34583421
Drug abuse	127.20	12.06	22	69555	99074	34788280
Glomerular filtration rate decreased	121.00	12.06	139	69438	12822	34874532
Angina pectoris	118.47	12.06	219	69358	31144	34856210
Haematoma	117.78	12.06	195	69382	25410	34861944
Inferior vena cava dilatation	112.61	12.06	46	69531	714	34886640
Dehydration	112.27	12.06	534	69043	129435	34757919
Therapeutic drug monitoring analysis not performed	111.19	12.06	42	69535	523	34886831
Ventricular arrhythmia	110.20	12.06	90	69487	5438	34881916
Neutropenia	108.03	12.06	92	69485	156686	34730668
Pallor	106.56	12.06	186	69391	25294	34862060
Dyspnoea at rest	106.46	12.06	76	69501	3752	34883602
Exercise tolerance decreased	102.30	12.06	84	69493	5114	34882240
Arrhythmia	98.27	12.06	219	69358	35589	34851765
Ventricular enlargement	97.73	12.06	40	69537	624	34886730
Completed suicide	95.35	12.06	38	69539	98130	34789224
Ejection fraction decreased	93.68	12.06	150	69427	19004	34868350
Febrile neutropenia	93.41	12.06	81	69496	136768	34750586
Melaena	92.21	12.06	212	69365	35168	34852186
Fall	91.77	12.06	704	68873	202181	34685173
Hypotension	88.25	12.06	747	68830	220902	34666452
Hyperkalaemia	88.08	12.06	321	69256	69068	34818286
Rash	85.38	12.06	199	69378	222553	34664801
Wound	84.78	12.06	125	69452	14739	34872615
Respiratory tract haemorrhage	84.24	12.06	44	69533	1226	34886128
Right ventricular failure	79.96	12.06	93	69484	8691	34878663
Condition aggravated	77.12	12.06	649	68928	191547	34695807
Hypokalaemia	77.01	12.06	273	69304	57941	34829413
Anxiety	75.22	12.06	53	69524	99375	34787979
Pulmonary hypertension	73.90	12.06	142	69435	20782	34866572
Computerised tomogram coronary artery abnormal	72.86	12.06	24	69553	193	34887161
Infusion related reaction	72.10	12.06	10	69567	53047	34834307
Malaise	70.37	12.06	167	69410	185658	34701696
Mitral valve incompetence	70.32	12.06	115	69462	14828	34872526
Fracture	69.98	12.06	77	69500	6772	34880582
Cardiac aneurysm	68.69	12.06	35	69542	925	34886429
Ventricular hypokinesia	68.46	12.06	69	69508	5483	34881871
Arthralgia	68.29	12.06	148	69429	169893	34717461
Musculoskeletal pain	67.83	12.06	177	69400	31786	34855568
Blood creatinine increased	67.75	12.06	370	69207	94606	34792748
Neuropathy peripheral	67.57	12.06	41	69536	83222	34804132
Urinary hesitation	67.46	12.06	51	69526	2751	34884603
Ventricular tachycardia	66.77	12.06	157	69420	26422	34860932
Chronic kidney disease	66.76	12.06	207	69370	41003	34846351
Weight increased	66.07	12.06	362	69215	92671	34794683
Urosepsis	63.64	12.06	101	69476	12698	34874656
Treatment failure	62.98	12.06	9	69568	46688	34840666
Tachypnoea	62.92	12.06	123	69454	18229	34869125
Pulmonary arterial hypertension	62.57	12.06	82	69495	8657	34878697
Low cardiac output syndrome	61.18	12.06	28	69549	580	34886774
Product dose omission issue	60.80	12.06	90	69487	119621	34767733
Degenerative mitral valve disease	59.27	12.06	22	69555	260	34887094
Hyperuricaemia	56.86	12.06	75	69502	7968	34879386
Aortic valve incompetence	56.25	12.06	64	69513	5840	34881514
Rales	56.20	12.06	83	69494	9800	34877554
Disease progression	56.11	12.06	80	69497	107997	34779357
Therapeutic drug monitoring analysis incorrectly performed	56.04	12.06	22	69555	306	34887048
Glomerular filtration rate abnormal	54.69	12.06	29	69548	834	34886520
Drug hypersensitivity	53.30	12.06	49	69528	80480	34806874
Febrile infection	52.69	12.06	40	69537	2171	34885183
Brain natriuretic peptide increased	51.65	12.06	60	69517	5599	34881755
Product use in unapproved indication	50.76	12.06	98	69479	117401	34769953
Waist circumference increased	50.60	12.06	28	69549	878	34886476
Rectal prolapse	50.58	12.06	23	69554	469	34886885
Hypochromic anaemia	49.67	12.06	28	69549	911	34886443
Atrial enlargement	49.54	12.06	25	69552	647	34886707
Agitation	48.35	12.06	27	69550	57372	34829982
Foetal exposure during pregnancy	47.69	12.06	9	69568	38092	34849262
Depression	47.37	12.06	75	69502	97023	34790331
Contraindicated product administered	46.64	12.06	120	69457	21361	34865993
Gamma-glutamyltransferase increased	46.57	12.06	146	69431	29085	34858269
Suicidal ideation	45.60	12.06	12	69565	40376	34846978
Dysuria	45.47	12.06	138	69439	27014	34860340
Deep vein thrombosis	45.23	12.06	38	69539	65210	34822144
Cardio-respiratory arrest	45.13	12.06	27	69550	55246	34832108
Death	44.96	12.06	542	69035	397507	34489847
Urticaria	44.89	12.06	35	69542	62342	34825012
Hepatic vein dilatation	44.76	12.06	17	69560	215	34887139
Paresis	44.43	12.06	36	69541	2150	34885204
Left ventricular failure	44.39	12.06	53	69524	5091	34882263
Diverticulum intestinal	44.22	12.06	47	69530	3974	34883380
Micturition disorder	43.55	12.06	36	69541	2212	34885142
Concomitant disease aggravated	43.17	12.06	55	69522	5646	34881708
Pleural effusion	43.10	12.06	294	69283	81252	34806102
Circulatory collapse	43.09	12.06	115	69462	20923	34866431
Nicotine dependence	42.68	12.06	22	69555	596	34886758
Left atrial enlargement	42.57	12.06	25	69552	880	34886474
Renal cyst haemorrhage	41.99	12.06	22	69555	617	34886737
Gastritis erosive	41.45	12.06	55	69522	5877	34881477
Injection site pain	41.43	12.06	13	69564	38992	34848362
Infective exacerbation of chronic obstructive airways disease	40.86	12.06	32	69545	1819	34885535
Helicobacter test positive	40.70	12.06	24	69553	851	34886503
Lower respiratory tract infection	40.62	12.06	7	69570	31630	34855724
Asthma	40.59	12.06	17	69560	42639	34844715
Osteochondrosis	40.31	12.06	26	69551	1084	34886270
Pulmonary vascular disorder	40.28	12.06	22	69555	672	34886682
Joint swelling	40.15	12.06	36	69541	59854	34827500
Renal cyst	40.13	12.06	68	69509	9025	34878329
Glycosylated haemoglobin increased	39.99	12.06	77	69500	11283	34876071
Intraductal papillary mucinous neoplasm	39.73	12.06	20	69557	515	34886839
Hypervolaemia	39.63	12.06	107	69470	19602	34867752
Aortic dilatation	39.38	12.06	28	69549	1373	34885981
Loss of personal independence in daily activities	39.13	12.06	9	69568	33170	34854184
Intentional overdose	39.07	12.06	19	69558	43655	34843699
Coronary artery stenosis	38.64	12.06	69	69508	9547	34877807
Abdominal wall haemorrhage	38.40	12.06	19	69558	471	34886883
Normocytic anaemia	38.20	12.06	34	69543	2310	34885044
Bradyarrhythmia	38.15	12.06	33	69544	2158	34885196
Therapeutic product effect incomplete	38.12	12.06	27	69550	50514	34836840
Musculoskeletal stiffness	37.83	12.06	23	69554	46657	34840697
Hepatojugular reflux	37.53	12.06	20	69557	581	34886773
Liver palpable	37.42	12.06	16	69561	280	34887074
Skin ulcer	37.28	12.06	113	69464	22103	34865251
Acute abdomen	37.23	12.06	31	69546	1924	34885430
Lethargy	36.62	12.06	18	69559	41104	34846250
Therapeutic response decreased	36.52	12.06	7	69570	29306	34858048
Eye injury	35.92	12.06	22	69555	837	34886517
Haematuria	35.63	12.06	195	69382	49871	34837483
Fluid retention	35.45	12.06	126	69451	26761	34860593
Vena cava injury	35.29	12.06	16	69561	324	34887030
Cardiac failure acute	35.21	12.06	70	69507	10500	34876854
Product administration error	35.17	12.06	91	69486	16253	34871101
White blood cell count decreased	35.10	12.06	87	69490	95358	34791996
Hypersensitivity	34.92	12.06	42	69535	60993	34826361
SARS-CoV-2 antibody test positive	34.90	12.06	17	69560	407	34886947
Intentional product misuse	34.89	12.06	24	69553	45587	34841767
Therapeutic product effect decreased	34.45	12.06	13	69564	34730	34852624
Gastrointestinal haemorrhage	34.44	12.06	297	69280	88180	34799174
Tachyarrhythmia	34.18	12.06	39	69538	3569	34883785
Drug intolerance	34.07	12.06	41	69536	59529	34827825
Delayed graft function	33.81	12.06	31	69546	2190	34885164
Back pain	33.41	12.06	127	69450	121662	34765692
Cardiovascular insufficiency	32.65	12.06	27	69550	1660	34885694
Headache	32.41	12.06	250	69327	200385	34686969
C-reactive protein increased	32.20	12.06	201	69376	53897	34833457
Type V hyperlipidaemia	32.11	12.06	20	69557	784	34886570
Abdominal pain lower	31.66	12.06	67	69510	10504	34876850
Congestive cardiomyopathy	31.61	12.06	55	69522	7455	34879899
Nasopharyngitis	31.39	12.06	57	69520	69911	34817443
Vascular anastomotic haemorrhage	31.36	12.06	14	69563	273	34887081
Drug ineffective for unapproved indication	30.99	12.06	5	69572	23710	34863644
Haematemesis	30.84	12.06	123	69454	27588	34859766
Erysipelas	30.81	12.06	43	69534	4820	34882534
Stress	30.69	12.06	11	69566	30336	34857018
Bone marrow failure	30.62	12.06	10	69567	29243	34858111
Tricuspid valve incompetence	30.56	12.06	63	69514	9697	34877657
Jugular vein distension	30.28	12.06	18	69559	648	34886706
Hyperparathyroidism secondary	30.14	12.06	25	69552	1543	34885811
Disorientation	29.77	12.06	138	69439	33050	34854304
Cough	29.60	12.06	441	69136	149699	34737655
Platelet distribution width increased	29.41	12.06	11	69566	133	34887221
Insomnia	29.37	12.06	107	69470	103800	34783554
Orthopnoea	29.22	12.06	43	69534	5060	34882294
Abnormal behaviour	28.99	12.06	7	69570	24962	34862392
Perineal cyst	28.86	12.06	13	69564	259	34887095
Depressed level of consciousness	28.58	12.06	164	69413	42677	34844677
Intestinal haemorrhage	28.50	12.06	35	69542	3461	34883893
Intentional product use issue	28.41	12.06	47	69530	59769	34827585
Suicide attempt	28.07	12.06	22	69555	39094	34848260
Vascular compression	27.75	12.06	14	69563	362	34886992
Procalcitonin increased	27.75	12.06	25	69552	1726	34885628
Nephrolithiasis	27.43	12.06	13	69564	30320	34857034
Peripheral venous disease	27.08	12.06	30	69547	2658	34884696
Carotid arteriosclerosis	26.48	12.06	25	69552	1833	34885521
Rhinorrhoea	26.47	12.06	9	69568	25659	34861695
Periarthritis calcarea	26.33	12.06	9	69568	82	34887272
Palisaded neutrophilic granulomatous dermatitis	26.11	12.06	5	69572	0	34887354
Articular calcification	26.05	12.06	9	69568	85	34887269
Peripheral arterial occlusive disease	26.01	12.06	44	69533	5830	34881524
Red cell distribution width increased	25.98	12.06	45	69532	6078	34881276
Pulmonary congestion	25.95	12.06	73	69504	13692	34873662
Low density lipoprotein abnormal	25.64	12.06	13	69564	340	34887014
Aortic valve sclerosis	25.62	12.06	19	69558	995	34886359
Type 2 diabetes mellitus	25.46	12.06	80	69497	15952	34871402
Urinary incontinence	25.35	12.06	89	69488	18785	34868569
Sinusitis	25.30	12.06	27	69550	41375	34845979
Pruritus	25.28	12.06	172	69405	141809	34745545
Renal function test abnormal	25.08	12.06	28	69549	2502	34884852
Upper gastrointestinal haemorrhage	25.05	12.06	109	69468	25409	34861945
Hypotonia	24.95	12.06	51	69526	7802	34879552
Thirst	24.76	12.06	51	69526	7844	34879510
Atrial thrombosis	24.56	12.06	26	69551	2188	34885166
Hypertensive crisis	24.53	12.06	54	69523	8697	34878657
Migraine	24.44	12.06	3	69574	17475	34869879
Drug reaction with eosinophilia and systemic symptoms	24.42	12.06	18	69559	32994	34854360
Heat stroke	24.20	12.06	18	69559	947	34886407
Medication error	24.19	12.06	108	69469	25457	34861897
Duodenitis	23.86	12.06	38	69539	4790	34882564
Activated partial thromboplastin time prolonged	23.63	12.06	53	69524	8642	34878712
Aortic arteriosclerosis	23.62	12.06	37	69540	4599	34882755
Arteriosclerotic gangrene	23.59	12.06	8	69569	71	34887283
Intraventricular haemorrhage	23.54	12.06	32	69545	3499	34883855
Coma	23.50	12.06	34	69543	45644	34841710
Disturbance in attention	23.35	12.06	108	69469	25837	34861517
Abdominal discomfort	23.22	12.06	53	69524	59782	34827572
COVID-19	23.16	12.06	78	69499	77472	34809882
Neurotoxicity	23.08	12.06	4	69573	18006	34869348
Blood glucose abnormal	23.01	12.06	42	69535	5910	34881444
Psoriasis	22.96	12.06	26	69551	38786	34848568
Neuroleptic malignant syndrome	22.95	12.06	4	69573	17930	34869424
Osteonecrosis of jaw	22.87	12.06	4	69573	17885	34869469
Hepatitis E antibody positive	22.86	12.06	11	69566	256	34887098
Prescribed underdose	22.68	12.06	53	69524	8880	34878474
Colitis	22.64	12.06	25	69552	37725	34849629
Left ventricular hypertrophy	22.60	12.06	50	69527	8080	34879274
Immature granulocyte count increased	22.55	12.06	9	69568	131	34887223
Oedema	22.44	12.06	162	69415	45579	34841775
Acute respiratory failure	22.36	12.06	121	69456	30807	34856547
Blood loss anaemia	22.33	12.06	50	69527	8144	34879210
Atrial flutter	22.28	12.06	75	69502	15499	34871855
Blood pressure decreased	22.21	12.06	177	69400	51338	34836016
Drug withdrawal syndrome	22.18	12.06	6	69571	19828	34867526
Acute respiratory distress syndrome	22.18	12.06	12	69565	25957	34861397
Product use issue	22.17	12.06	59	69518	63157	34824197
Drug resistance	22.11	12.06	12	69565	25915	34861439
Immobile	22.02	12.06	26	69551	2468	34884886
Left ventricular enlargement	22.00	12.06	15	69562	687	34886667
Ventricular extrasystoles	21.97	12.06	63	69514	11945	34875409
Prostate cancer	21.92	12.06	28	69549	39621	34847733
Influenza like illness	21.86	12.06	14	69563	27620	34859734
Premature baby	21.84	12.06	6	69571	19627	34867727
Neutrophil count decreased	21.72	12.06	43	69534	51061	34836293
Hepatitis E virus test positive	21.68	12.06	11	69566	288	34887066
Blood pressure systolic decreased	21.65	12.06	35	69542	4468	34882886
Encephalopathy	21.62	12.06	23	69554	35296	34852058
Traumatic haemothorax	21.58	12.06	11	69566	291	34887063
Mitral valve thickening	21.52	12.06	12	69565	382	34886972
Haemothorax	21.39	12.06	32	69545	3820	34883534
Stenosis	21.34	12.06	20	69557	1453	34885901
Internal haemorrhage	21.32	12.06	37	69540	5004	34882350
Adrenal cyst	21.23	12.06	9	69568	154	34887200
Post-traumatic amnestic disorder	21.17	12.06	7	69570	57	34887297
Hyperventilation	21.00	12.06	27	69550	2797	34884557
Blood pressure increased	20.97	12.06	97	69480	88005	34799349
Mental status changes	20.95	12.06	27	69550	38056	34849298
Influenza	20.93	12.06	42	69535	49624	34837730
Pleurothotonus	20.68	12.06	18	69559	1187	34886167
Interstitial lung disease	20.65	12.06	64	69513	65218	34822136
Skin pressure mark	20.56	12.06	7	69570	63	34887291
Hallucination	20.48	12.06	45	69532	51453	34835901
Gastrointestinal adenocarcinoma	20.46	12.06	7	69570	64	34887290
Therapy non-responder	20.27	12.06	29	69548	39117	34848237
Unevaluable event	20.20	12.06	21	69556	32569	34854785
Hepatic calcification	20.14	12.06	11	69566	336	34887018
Pulmonary embolism	20.08	12.06	101	69476	89645	34797709
Bladder cancer	20.04	12.06	4	69573	16274	34871080
Psychotic disorder	19.88	12.06	12	69565	24440	34862914
Cardiovascular somatic symptom disorder	19.87	12.06	6	69571	35	34887319
Respiratory arrest	19.84	12.06	16	69561	28027	34859327
Blood 25-hydroxycholecalciferol decreased	19.81	12.06	10	69567	259	34887095
Blood potassium increased	19.80	12.06	75	69502	16420	34870934
Small intestinal obstruction	19.73	12.06	3	69574	14863	34872491
Fluid intake reduced	19.50	12.06	30	69547	3671	34883683
Cardiorenal syndrome	19.29	12.06	14	69563	709	34886645
Renal artery stenosis	19.02	12.06	23	69554	2238	34885116
Sedation	18.99	12.06	9	69568	20997	34866357
Renal failure	18.95	12.06	365	69212	130192	34757162
Urogenital haemorrhage	18.92	12.06	14	69563	731	34886623
Spinal osteoarthritis	18.87	12.06	45	69532	7638	34879716
Blood glucose fluctuation	18.85	12.06	31	69546	4013	34883341
Systolic dysfunction	18.75	12.06	25	69552	2683	34884671
Psoriatic arthropathy	18.66	12.06	8	69569	19790	34867564
Arthritis	18.54	12.06	21	69556	31325	34856029
Hyperglycaemia	18.32	12.06	138	69439	39342	34848012
Cardiac amyloidosis	18.15	12.06	17	69560	1234	34886120
Atrioventricular block complete	18.14	12.06	50	69527	9269	34878085
Lung diffusion test abnormal	17.92	12.06	6	69571	51	34887303
Mucosal haemorrhage	17.88	12.06	19	69558	1606	34885748
Polyuria	17.69	12.06	47	69530	8527	34878827
Left ventricular false tendon	17.62	12.06	6	69571	54	34887300
Vision blurred	17.60	12.06	41	69536	45922	34841432
Blood urea increased	17.55	12.06	112	69465	30252	34857102
Appendicitis	17.49	12.06	4	69573	14803	34872551
Genitourinary tract infection	17.47	12.06	7	69570	103	34887251
Costal cartilage fracture	17.42	12.06	9	69568	245	34887109
Suspected transmission of an infectious agent via product	17.31	12.06	14	69563	834	34886520
Diplopia	17.21	12.06	6	69571	16837	34870517
Faecaloma	17.18	12.06	35	69542	5342	34882012
Cytomegalovirus infection	17.16	12.06	16	69561	26119	34861235
Sepsis	17.14	12.06	231	69346	166330	34721024
Mean cell volume increased	17.14	12.06	26	69551	3143	34884211
Arthropathy	17.06	12.06	17	69560	26890	34860464
Hyperhidrosis	17.04	12.06	85	69492	75607	34811747
Peripheral artery stenosis	16.97	12.06	14	69563	858	34886496
Respiratory distress	16.95	12.06	28	69549	35637	34851717
Hiatus hernia	16.89	12.06	43	69534	7602	34879752
Inferior vena cava syndrome	16.89	12.06	6	69571	62	34887292
Obstructive airways disorder	16.75	12.06	5	69572	15489	34871865
Thoracic haemorrhage	16.64	12.06	8	69569	186	34887168
Intervertebral disc space narrowing	16.59	12.06	15	69562	1040	34886314
Activated partial thromboplastin time shortened	16.57	12.06	11	69566	482	34886872
Akinesia	16.43	12.06	21	69556	2163	34885191
Blood pressure systolic increased	16.35	12.06	13	69564	22939	34864415
Irritability	16.35	12.06	15	69562	24675	34862679
Overdose	16.35	12.06	110	69467	90949	34796405
No adverse event	16.32	12.06	13	69564	22914	34864440
Myelosuppression	16.31	12.06	9	69568	19256	34868098
Adenocarcinoma of appendix	16.19	12.06	7	69570	126	34887228
Rash macular	16.14	12.06	3	69574	12839	34874515
Insulin autoimmune syndrome	16.13	12.06	9	69568	287	34887067
N-terminal prohormone brain natriuretic peptide abnormal	16.07	12.06	8	69569	201	34887153
Scrotal oedema	16.06	12.06	19	69558	1807	34885547
Cold sweat	16.01	12.06	50	69527	9937	34877417
Rash pruritic	15.98	12.06	18	69559	26923	34860431
Mucosal inflammation	15.98	12.06	33	69544	38589	34848765
Paraplegia	15.91	12.06	24	69553	2887	34884467
Lower gastrointestinal haemorrhage	15.78	12.06	48	69529	9404	34877950
Anaphylactic shock	15.74	12.06	6	69571	15935	34871419
Intentional self-injury	15.72	12.06	4	69573	13767	34873587
Plasma cell myeloma	15.69	12.06	38	69539	41999	34845355
Paraesthesia	15.65	12.06	70	69507	64102	34823252
Testicular swelling	15.60	12.06	18	69559	1667	34885687
Rash erythematous	15.58	12.06	16	69561	24961	34862393
Bacteraemia	15.58	12.06	10	69567	19707	34867647
Rheumatoid arthritis	15.55	12.06	33	69544	38205	34849149
Oliguria	15.37	12.06	44	69533	8336	34879018
Congenital vas deferens absence	15.31	12.06	5	69572	39	34887315
Congenital muscle absence	15.31	12.06	5	69572	39	34887315
Non-compaction cardiomyopathy	15.31	12.06	5	69572	39	34887315
Diabetic foot	15.25	12.06	23	69554	2765	34884589
Hepatic cytolysis	15.09	12.06	5	69572	14491	34872863
Heart rate decreased	15.02	12.06	25	69552	31720	34855634
Mitral valve calcification	15.00	12.06	11	69566	566	34886788
Actinic keratosis	14.91	12.06	30	69547	4537	34882817
Inguinal hernia	14.87	12.06	41	69536	7600	34879754
Hepatic cirrhosis	14.79	12.06	71	69506	17243	34870111
Paranoia	14.78	12.06	3	69574	12065	34875289
Anaphylactic reaction	14.76	12.06	26	69551	32275	34855079
Hepatorenal syndrome	14.60	12.06	22	69555	2644	34884710
Rectal haemorrhage	14.54	12.06	37	69540	40212	34847142
Seizure	14.50	12.06	136	69441	104721	34782633
Micturition frequency decreased	14.47	12.06	9	69568	352	34887002
Stress urinary incontinence	14.41	12.06	6	69571	98	34887256
Bacterial infection	14.40	12.06	8	69569	17055	34870299
Sacroiliac joint dysfunction	14.40	12.06	5	69572	48	34887306
Adrenal adenoma	14.29	12.06	10	69567	478	34886876
Adrenomegaly	14.29	12.06	9	69568	360	34886994
Cardiac failure congestive	14.26	12.06	239	69338	83031	34804323
Pneumocystis jirovecii pneumonia	14.25	12.06	11	69566	19699	34867655
Subarachnoid haematoma	14.23	12.06	8	69569	259	34887095
Extrapyramidal disorder	14.21	12.06	4	69573	12876	34874478
Papillary renal cell carcinoma	14.20	12.06	8	69569	260	34887094
Anhidrosis	14.14	12.06	6	69571	103	34887251
Chronic coronary syndrome	14.13	12.06	7	69570	174	34887180
Pulmonary mass	14.09	12.06	4	69573	12808	34874546
Injection site erythema	14.09	12.06	7	69570	15892	34871462
Abdominal distension	14.02	12.06	178	69399	58314	34829040
Blast cells present	14.02	12.06	10	69567	493	34886861
Albumin urine present	13.96	12.06	9	69568	375	34886979
Aggression	13.94	12.06	36	69541	38928	34848426
Metamyelocyte count increased	13.92	12.06	9	69568	377	34886977
Urogenital infection bacterial	13.71	12.06	5	69572	56	34887298
Cardiac arrest	13.60	12.06	124	69453	96035	34791319
Pain	13.60	12.06	307	69270	204368	34682986
Lymphoma	13.58	12.06	4	69573	12503	34874851
Disseminated intravascular coagulation	13.58	12.06	14	69563	21802	34865552
Pollakiuria	13.57	12.06	76	69501	19598	34867756
Blood potassium abnormal	13.46	12.06	15	69562	1337	34886017
Haemoglobin decreased	13.45	12.06	325	69252	120447	34766907
Bladder tamponade	13.35	12.06	10	69567	532	34886822
Haemoptysis	13.34	12.06	117	69460	34889	34852465
Vitamin B6 deficiency	13.31	12.06	7	69570	198	34887156
Iron deficiency anaemia	13.26	12.06	48	69529	10281	34877073
Prothrombin time prolonged	13.19	12.06	45	69532	9361	34877993
Respiratory depression	13.16	12.06	8	69569	16237	34871117
Hepatosplenomegaly	13.16	12.06	27	69550	4142	34883212
Disease recurrence	13.14	12.06	14	69563	21476	34865878
Pneumonitis	13.14	12.06	30	69547	33848	34853506
Anxiety disorder	13.10	12.06	17	69560	1777	34885577
Subclavian artery occlusion	13.08	12.06	6	69571	125	34887229
Large intestine polyp	13.03	12.06	40	69537	7874	34879480
Dysdiadochokinesis	13.02	12.06	7	69570	207	34887147
Occult blood	12.99	12.06	12	69565	856	34886498
Polypectomy	12.90	12.06	10	69567	560	34886794
Multiple sclerosis relapse	12.87	12.06	5	69572	13128	34874226
Unresponsive to stimuli	12.77	12.06	22	69555	27547	34859807
Injection site reaction	12.71	12.06	5	69572	13028	34874326
Fungal infection	12.70	12.06	8	69569	15927	34871427
Oral pain	12.64	12.06	3	69574	10824	34876530
Drug interaction	12.62	12.06	560	69017	225386	34661968
Skin exfoliation	12.61	12.06	22	69555	27410	34859944
Ascites	12.59	12.06	145	69432	46426	34840928
Mouth ulceration	12.59	12.06	4	69573	11906	34875448
Benign gastrointestinal neoplasm	12.50	12.06	6	69571	139	34887215
Cachexia	12.47	12.06	37	69540	7149	34880205
Hypertrophy	12.47	12.06	9	69568	452	34886902
Gastrointestinal disorder	12.43	12.06	31	69546	33917	34853437
Complications of transplanted kidney	12.42	12.06	28	69549	4581	34882773
Gallbladder hypofunction	12.38	12.06	3	69574	6	34887348
Foot amputation	12.33	12.06	11	69566	750	34886604
Fear of falling	12.29	12.06	8	69569	339	34887015
Diabetic nephropathy	12.28	12.06	18	69559	2110	34885244
Vertigo	12.26	12.06	90	69487	25446	34861908
Swelling of eyelid	12.24	12.06	13	69564	1098	34886256
Eosinophilia	12.08	12.06	21	69556	26201	34861153
Hyperchromic anaemia	12.08	12.06	6	69571	150	34887204

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	3457.45	11.34	3102	122828	272136	79346322
Product prescribing error	1426.62	11.34	886	125044	43927	79574531
Product monitoring error	1247.10	11.34	485	125445	8421	79610037
Cardiac failure	1114.31	11.34	1296	124634	153546	79464912
Haematochezia	1101.11	11.34	991	124939	86654	79531804
Oedema peripheral	1069.50	11.34	1629	124301	250659	79367799
Dyspnoea	848.47	11.34	3116	122814	853909	78764549
Systemic infection	727.97	11.34	340	125590	9412	79609046
Drug ineffective	723.23	11.34	407	125523	1080506	78537952
Anaemia	701.25	11.34	1903	124027	443112	79175346
Renal impairment	642.44	11.34	1001	124929	156782	79461676
Labelled drug-drug interaction medication error	525.71	11.34	398	125532	27252	79591206
Atrial fibrillation	467.07	11.34	991	124939	196895	79421563
Acute kidney injury	459.63	11.34	1826	124104	517578	79100880
Dehydration	422.90	11.34	1094	124836	247093	79371365
Electrolyte imbalance	422.89	11.34	367	125563	30514	79587944
Syncope	407.66	11.34	885	125045	178564	79439894
Off label use	380.89	11.34	528	125402	906687	78711771
Bradycardia	375.75	11.34	726	125204	134831	79483627
Cardiac failure chronic	331.04	11.34	211	125719	10924	79607534
Electrocardiogram abnormal	327.17	11.34	245	125685	16492	79601966
Therapeutic drug monitoring analysis not performed	301.64	11.34	114	125816	1822	79616636
Fall	284.55	11.34	1518	124412	486111	79132347
Rash	265.50	11.34	314	125616	578044	79040414
Dyspnoea exertional	264.33	11.34	485	125445	86588	79531870
Dizziness	264.29	11.34	1574	124356	524867	79093591
Joint swelling	262.89	11.34	66	125864	288580	79329878
Infusion related reaction	256.70	11.34	31	125899	230206	79388252
Arrhythmia	250.73	11.34	390	125540	60882	79557576
Pallor	242.66	11.34	345	125585	49717	79568741
Drug hypersensitivity	238.50	11.34	87	125843	298829	79319629
Drug intolerance	231.75	11.34	65	125865	264054	79354404
Hyperkalaemia	229.18	11.34	537	125393	113861	79504597
Completed suicide	226.08	11.34	55	125875	245712	79372746
Hypotension	224.95	11.34	1323	124607	438994	79179464
Synovitis	222.13	11.34	3	125927	150731	79467727
Arthropathy	221.08	11.34	15	125915	177096	79441362
Toxicity to various agents	214.23	11.34	210	125720	421330	79197128
Treatment failure	214.10	11.34	14	125916	170472	79447986
Hypersensitivity	204.69	11.34	79	125851	262160	79356298
Pulmonary arterial hypertension	201.11	11.34	236	125694	28130	79590328
Glomerular filtration rate decreased	200.75	11.34	212	125718	22490	79595968
Melaena	199.90	11.34	351	125579	60539	79557919
Angina pectoris	198.83	11.34	320	125610	51412	79567046
Arthralgia	195.17	11.34	380	125550	571423	79047035
Haematoma	194.00	11.34	318	125612	51877	79566581
Therapeutic product effect decreased	193.02	11.34	18	125912	163845	79454613
Hypokalaemia	183.41	11.34	572	125358	143468	79474990
N-terminal prohormone brain natriuretic peptide increased	182.17	11.34	106	125824	4649	79613809
Haematemesis	172.49	11.34	302	125628	51962	79566496
Rheumatoid arthritis	169.07	11.34	59	125871	208411	79410047
Musculoskeletal stiffness	167.22	11.34	36	125894	174972	79443486
Alopecia	165.69	11.34	79	125851	231276	79387182
Blood creatinine increased	164.60	11.34	579	125351	154478	79463980
Lower respiratory tract infection	164.05	11.34	10	125920	129210	79489248
Tachypnoea	161.34	11.34	225	125705	31838	79586620
Product administration error	161.03	11.34	224	125706	31622	79586836
Drug abuse	156.39	11.34	33	125897	162658	79455800
Right ventricular failure	155.89	11.34	189	125741	23308	79595150
Systemic lupus erythematosus	154.94	11.34	9	125921	121140	79497318
Glossodynia	144.45	11.34	4	125926	103333	79515125
Drug interaction	141.66	11.34	1130	124800	414053	79204405
Fluid retention	141.16	11.34	329	125601	69480	79548978
Nasopharyngitis	140.15	11.34	117	125813	253764	79364694
Pulmonary hypertension	139.81	11.34	263	125667	47817	79570641
Hyponatraemia	138.25	11.34	602	125328	177246	79441212
Malaise	132.84	11.34	368	125562	489501	79128957
Chronic kidney disease	131.82	11.34	310	125620	65844	79552614
Abdominal discomfort	128.27	11.34	124	125806	250603	79367855
Orthostatic intolerance	128.03	11.34	62	125868	1862	79616596
Urticaria	126.93	11.34	67	125863	185134	79433324
Sinusitis	126.41	11.34	76	125854	195425	79423033
Febrile neutropenia	124.38	11.34	109	125821	230890	79387568
Mitral valve incompetence	121.27	11.34	185	125745	28380	79590078
Hypervolaemia	121.01	11.34	231	125699	42459	79575999
Injection site pain	119.44	11.34	29	125901	129809	79488649
Gastrointestinal haemorrhage	118.60	11.34	505	125425	147214	79471244
Exercise tolerance decreased	118.52	11.34	105	125825	8966	79609492
Inferior vena cava dilatation	116.84	11.34	46	125884	825	79617633
Pain	113.06	11.34	651	125279	703151	78915307
Dyspnoea at rest	112.70	11.34	93	125837	7209	79611249
Ventricular arrhythmia	110.89	11.34	100	125830	8740	79609718
Discomfort	108.10	11.34	32	125898	125585	79492873
Fracture	106.72	11.34	151	125779	21650	79596808
Renal failure	105.63	11.34	609	125321	200359	79418099
Therapeutic product effect incomplete	105.05	11.34	46	125884	141599	79476859
Hepatic enzyme increased	103.42	11.34	82	125848	182528	79435930
Ventricular enlargement	102.92	11.34	40	125890	692	79617766
Product use issue	102.47	11.34	108	125822	209714	79408744
Disorientation	101.79	11.34	272	125658	62504	79555954
Anuria	100.86	11.34	144	125786	20819	79597639
Anxiety	96.50	11.34	152	125778	248360	79370098
Arthritis	95.73	11.34	31	125899	114849	79503609
Hyperglycaemia	95.70	11.34	286	125644	70049	79548409
Maternal exposure during pregnancy	95.62	11.34	48	125882	136490	79481968
Neutropenia	95.52	11.34	194	125736	287516	79330942
Dysuria	94.23	11.34	232	125698	50719	79567739
Condition aggravated	93.30	11.34	1204	124726	499920	79118538
Therapeutic drug monitoring analysis incorrectly performed	93.20	11.34	37	125893	679	79617779
Respiratory tract haemorrhage	92.78	11.34	49	125881	1774	79616684
Diverticulum intestinal	91.88	11.34	89	125841	8516	79609942
Swelling	91.52	11.34	125	125805	216586	79401872
Product use in unapproved indication	90.84	11.34	160	125770	250199	79368259
Pericarditis	90.70	11.34	26	125904	104210	79514248
Intentional product use issue	89.07	11.34	66	125864	152046	79466412
Pleural effusion	88.97	11.34	459	125471	144803	79473655
Circulatory collapse	87.89	11.34	188	125742	37480	79580978
Haematuria	87.20	11.34	273	125657	68563	79549895
Pruritus	86.97	11.34	325	125605	394323	79224135
Loss of personal independence in daily activities	86.69	11.34	27	125903	102553	79515905
Glomerular filtration rate abnormal	85.87	11.34	45	125885	1603	79616855
Tachycardia	85.25	11.34	526	125404	177242	79441216
Back pain	84.21	11.34	226	125704	303954	79314504
Upper gastrointestinal haemorrhage	83.61	11.34	195	125735	41185	79577273
Cardiac failure acute	82.34	11.34	124	125806	18805	79599653
Waist circumference increased	82.01	11.34	44	125886	1645	79616813
Tachyarrhythmia	81.95	11.34	76	125854	6886	79611572
Neuropathy peripheral	81.85	11.34	62	125868	141243	79477215
Blood loss anaemia	81.33	11.34	111	125819	15387	79603071
Psoriatic arthropathy	80.99	11.34	13	125917	77986	79540472
Tricuspid valve incompetence	79.94	11.34	125	125805	19587	79598871
Musculoskeletal pain	79.88	11.34	347	125583	102007	79516451
Urosepsis	79.60	11.34	147	125783	26348	79592110
Helicobacter infection	78.58	11.34	9	125921	69695	79548763
Computerised tomogram coronary artery abnormal	78.21	11.34	24	125906	194	79618264
Atrial flutter	76.63	11.34	129	125801	21496	79596962
Ventricular tachycardia	76.54	11.34	190	125740	41745	79576713
Urinary hesitation	75.78	11.34	59	125871	4207	79614251
Medication error	75.08	11.34	259	125671	68383	79550075
Gamma-glutamyltransferase increased	73.11	11.34	221	125709	54459	79563999
Asthma	72.37	11.34	64	125866	135031	79483427
Headache	71.52	11.34	674	125256	653098	78965360
Folliculitis	71.14	11.34	4	125926	55376	79563082
Ejection fraction decreased	71.01	11.34	164	125766	34413	79584045
Haemoglobin decreased	70.96	11.34	596	125334	221523	79396935
Blood urea increased	70.77	11.34	203	125727	48587	79569871
Pancreatic steatosis	70.52	11.34	35	125895	1110	79617348
Stomatitis	68.91	11.34	78	125852	146679	79471779
Ventricular hypokinesia	68.77	11.34	79	125851	9200	79609258
Depression	67.89	11.34	151	125779	216639	79401819
Irritable bowel syndrome	67.81	11.34	9	125921	62232	79556226
Exposure during pregnancy	67.21	11.34	38	125892	101094	79517364
Cardiac aneurysm	66.66	11.34	37	125893	1481	79616977
Fibromyalgia	66.18	11.34	11	125919	64329	79554129
Abdominal pain lower	65.55	11.34	151	125779	31631	79586827
Migraine	65.52	11.34	28	125902	87465	79530993
Brain natriuretic peptide increased	64.66	11.34	75	125855	8825	79609633
Bradyarrhythmia	64.39	11.34	53	125877	4093	79614365
Gastrointestinal disorder	62.96	11.34	60	125870	122145	79496313
Hyperuricaemia	62.66	11.34	85	125845	11714	79606744
Degenerative mitral valve disease	61.86	11.34	22	125908	293	79618165
Hypotonia	61.31	11.34	88	125842	12782	79605676
Cardio-respiratory arrest	61.07	11.34	49	125881	108461	79509997
Left ventricular failure	60.21	11.34	75	125855	9506	79608952
Suicidal ideation	57.85	11.34	24	125906	76316	79542142
C-reactive protein abnormal	57.77	11.34	5	125925	48362	79570096
Renal function test abnormal	57.75	11.34	54	125876	4944	79613514
Aortic valve incompetence	57.34	11.34	73	125857	9457	79609001
Acute respiratory failure	56.90	11.34	215	125715	59326	79559132
Glycosylated haemoglobin increased	56.78	11.34	106	125824	19154	79599304
Paraesthesia	56.70	11.34	121	125809	176202	79442256
Insomnia	56.53	11.34	198	125732	244972	79373486
Faecaloma	56.46	11.34	80	125850	11484	79606974
Cardiac failure congestive	55.94	11.34	401	125529	142001	79476457
Thirst	55.55	11.34	103	125827	18516	79599942
Blister	55.54	11.34	64	125866	119412	79499046
Injection site erythema	55.48	11.34	27	125903	78170	79540288
Internal haemorrhage	55.27	11.34	69	125861	8764	79609694
Lactic acidosis	55.24	11.34	239	125691	70120	79548338
Blood cholesterol increased	54.85	11.34	32	125898	83688	79534770
Lethargy	54.80	11.34	30	125900	81262	79537196
Helicobacter test positive	54.38	11.34	31	125899	1307	79617151
Product dose omission issue	54.37	11.34	204	125726	247333	79371125
Orthopnoea	54.15	11.34	73	125857	10000	79608458
Concomitant disease aggravated	54.09	11.34	84	125846	13083	79605375
Peripheral arterial occlusive disease	54.08	11.34	66	125864	8192	79610266
Dementia	54.02	11.34	120	125810	24539	79593919
Therapeutic response decreased	54.02	11.34	19	125911	66834	79551624
Arterial haemorrhage	53.43	11.34	39	125891	2522	79615936
Sleep disorder due to general medical condition, insomnia type	53.42	11.34	4	125926	43552	79574906
Hypoaesthesia	52.87	11.34	129	125801	179223	79439235
Injection site reaction	52.85	11.34	11	125919	54774	79563684
Depressed level of consciousness	52.10	11.34	295	125635	96357	79522101
Gastritis erosive	51.43	11.34	74	125856	10773	79607685
Abdominal wall haemorrhage	51.17	11.34	24	125906	670	79617788
Anaphylactic reaction	50.76	11.34	35	125895	83708	79534750
Low cardiac output syndrome	50.12	11.34	27	125903	1018	79617440
Femoral hernia incarcerated	49.68	11.34	25	125905	817	79617641
Joint stiffness	49.37	11.34	4	125926	40826	79577632
Coronary artery stenosis	49.01	11.34	78	125852	12406	79606052
Hypochromic anaemia	48.76	11.34	38	125892	2713	79615745
Stress	48.62	11.34	33	125897	79579	79538879
Psoriasis	48.51	11.34	42	125888	89545	79528913
Febrile infection	48.29	11.34	41	125889	3305	79615153
Drug ineffective for unapproved indication	47.98	11.34	11	125919	51227	79567231
Hepatic vein dilatation	47.49	11.34	17	125913	231	79618227
Polyuria	47.25	11.34	85	125845	14929	79603529
Mobility decreased	47.13	11.34	75	125855	122100	79496358
Erysipelas	47.08	11.34	71	125859	10779	79607679
Low density lipoprotein abnormal	47.08	11.34	20	125910	439	79618019
Flatulence	46.53	11.34	161	125769	42563	79575895
Coma	45.62	11.34	55	125875	100594	79517864
Blood potassium increased	45.59	11.34	125	125805	29150	79589308
Hyperparathyroidism secondary	45.54	11.34	36	125894	2624	79615834
Vena cava injury	45.15	11.34	18	125912	334	79618124
Renal cyst haemorrhage	45.15	11.34	22	125908	670	79617788
Peripheral circulatory failure	45.10	11.34	26	125904	1120	79617338
Lymphatic fistula	44.92	11.34	23	125907	780	79617678
Atrial enlargement	44.65	11.34	25	125905	1018	79617440
Pulmonary congestion	44.50	11.34	118	125812	26982	79591476
Oropharyngeal pain	44.22	11.34	65	125865	109288	79509170
Intentional product misuse	44.21	11.34	51	125879	95114	79523344
Pulmonary vascular disorder	44.20	11.34	25	125905	1038	79617420
Left atrial enlargement	43.93	11.34	26	125904	1177	79617281
Procalcitonin increased	43.73	11.34	37	125893	2969	79615489
Micturition disorder	43.64	11.34	42	125888	3986	79614472
Injury	43.60	11.34	35	125895	77461	79540997
Atrioventricular block complete	43.56	11.34	87	125843	16523	79601935
Paresis	43.49	11.34	43	125887	4218	79614240
Blood pressure systolic increased	43.32	11.34	26	125904	66960	79551498
Lower gastrointestinal haemorrhage	42.94	11.34	85	125845	16040	79602418
Aortic valve stenosis	42.52	11.34	47	125883	5247	79613211
Aortic arteriosclerosis	42.51	11.34	61	125869	8857	79609601
Hypoglycaemia	42.18	11.34	290	125640	101304	79517154
Ascites	41.63	11.34	232	125698	75330	79543128
White blood cell count decreased	41.45	11.34	155	125775	188133	79430325
Prothrombin time prolonged	41.34	11.34	86	125844	16813	79601645
Therapy non-responder	41.24	11.34	51	125879	92254	79526204
Rhinorrhoea	40.78	11.34	36	125894	76038	79542420
Hepatojugular reflux	40.48	11.34	20	125910	628	79617830
Abdominal distension	39.75	11.34	324	125606	119326	79499132
Intentional self-injury	39.69	11.34	3	125927	32416	79586042
Restlessness	39.66	11.34	162	125768	46330	79572128
Cardiorenal syndrome	39.66	11.34	27	125903	1562	79616896
Renal cyst	39.64	11.34	78	125852	14654	79603804
Atrial thrombosis	39.38	11.34	38	125892	3618	79614840
COVID-19	39.31	11.34	123	125807	157551	79460907
Injection site swelling	38.76	11.34	13	125917	47119	79571339
Blood uric acid increased	38.72	11.34	73	125857	13287	79605171
N-terminal prohormone brain natriuretic peptide abnormal	38.57	11.34	15	125915	260	79618198
Nicotine dependence	38.47	11.34	22	125908	933	79617525
Influenza	38.36	11.34	93	125837	129513	79488945
SARS-CoV-2 antibody test positive	38.09	11.34	17	125913	422	79618036
Liver palpable	37.92	11.34	16	125914	345	79618113
Infective exacerbation of chronic obstructive airways disease	37.92	11.34	33	125897	2751	79615707
Intentional overdose	37.24	11.34	69	125861	105891	79512567
Knee arthroplasty	37.22	11.34	11	125919	43237	79575221
Blood pressure increased	36.80	11.34	190	125740	211170	79407288
Intraductal papillary mucinous neoplasm	36.55	11.34	20	125910	778	79617680
Cardiogenic shock	36.51	11.34	147	125783	41767	79576691
Disturbance in attention	36.43	11.34	168	125762	50633	79567825
Hypertensive crisis	35.70	11.34	92	125838	20678	79597780
Product used for unknown indication	35.63	11.34	25	125905	1519	79616939
Polyneuropathy	35.52	11.34	101	125829	24050	79594408
Osteoarthritis	35.20	11.34	52	125878	87257	79531201
Left-to-right cardiac shunt	34.51	11.34	11	125919	102	79618356
Vascular anastomotic haemorrhage	34.48	11.34	14	125916	273	79618185
Duodenitis	34.38	11.34	52	125878	7915	79610543
Osteochondrosis	34.15	11.34	27	125903	1969	79616489
Coagulation test abnormal	33.92	11.34	23	125907	1322	79617136
Osteonecrosis of jaw	33.71	11.34	13	125917	43213	79575245
Disease progression	33.66	11.34	163	125767	184199	79434259
Intraventricular haemorrhage	33.54	11.34	40	125890	4847	79613611
Obstructive airways disorder	33.21	11.34	5	125925	31454	79587004
Multiple sclerosis relapse	33.11	11.34	16	125914	46517	79571941
Oedema	33.06	11.34	311	125619	119269	79499189
Vascular resistance pulmonary decreased	33.01	11.34	10	125920	77	79618381
Haemoptysis	32.91	11.34	175	125755	55824	79562634
Retrograde amnesia	32.90	11.34	17	125913	588	79617870
Acute abdomen	32.66	11.34	32	125898	3105	79615353
Nephrolithiasis	32.66	11.34	22	125908	53269	79565189
Injection site bruising	32.53	11.34	12	125918	40990	79577468
Injection site pruritus	32.51	11.34	13	125917	42270	79576188
Burning sensation	32.33	11.34	27	125903	58605	79559853
Epistaxis	32.33	11.34	293	125637	111222	79507236
Jugular vein distension	32.07	11.34	23	125907	1447	79617011
Aortic dilatation	32.05	11.34	25	125905	1787	79616671
Perineal cyst	31.90	11.34	13	125917	256	79618202
Feeling abnormal	31.90	11.34	136	125794	159063	79459395
Platelet distribution width increased	31.82	11.34	11	125919	134	79618324
Influenza like illness	31.64	11.34	40	125890	71667	79546791
Type V hyperlipidaemia	31.58	11.34	20	125910	1023	79617435
Rash pruritic	31.56	11.34	40	125890	71589	79546869
Congestive cardiomyopathy	31.25	11.34	62	125868	11718	79606740
Transfusion	31.17	11.34	89	125841	21241	79597217
Ill-defined disorder	30.92	11.34	35	125895	65840	79552618
Activated partial thromboplastin time prolonged	30.90	11.34	69	125861	14159	79604299
Cardioversion	30.88	11.34	26	125904	2072	79616386
Neutrophil count decreased	30.59	11.34	64	125866	93895	79524563
Cardiovascular insufficiency	30.27	11.34	30	125900	2951	79615507
Congenital coronary artery malformation	30.18	11.34	10	125920	106	79618352
Blood pressure fluctuation	30.10	11.34	37	125893	67108	79551350
Hiatus hernia	30.01	11.34	93	125837	23219	79595239
Respiratory arrest	29.93	11.34	28	125902	57522	79560936
Sleep disorder	29.92	11.34	56	125874	85621	79532837
Pulmonary oedema	29.85	11.34	240	125690	88014	79530444
Incorrect route of product administration	29.85	11.34	9	125921	34920	79583538
Rales	29.76	11.34	84	125846	19917	79598541
Delayed graft function	29.67	11.34	32	125898	3475	79614983
Neoplasm progression	29.50	11.34	23	125907	51659	79566799
Hepatic cytolysis	29.39	11.34	4	125926	27147	79591311
Drug resistance	29.30	11.34	15	125915	42198	79576260
Dry eye	28.98	11.34	11	125919	36920	79581538
Pregnancy	28.97	11.34	4	125926	26847	79591611
Mental status changes	28.87	11.34	38	125892	66921	79551537
Ventricular extrasystoles	28.58	11.34	82	125848	19622	79598836
Stasis dermatitis	28.58	11.34	21	125909	1372	79617086
Eructation	28.44	11.34	57	125873	10852	79607606
Bundle branch block right	28.39	11.34	58	125872	11193	79607265
Adverse drug reaction	28.30	11.34	38	125892	66354	79552104
Adverse event	28.25	11.34	32	125898	60182	79558276
Aortic valve sclerosis	28.16	11.34	23	125907	1757	79616701
Red blood cell sedimentation rate increased	28.11	11.34	19	125911	45923	79572535
Pain in extremity	28.02	11.34	406	125524	364132	79254326
Periarthritis calcarea	28.00	11.34	9	125921	86	79618372
Wound infection pseudomonas	27.89	11.34	22	125908	1599	79616859
Gastritis	27.53	11.34	149	125781	47844	79570614
Hip arthroplasty	27.48	11.34	11	125919	35745	79582713
Upper respiratory tract infection	27.31	11.34	65	125865	91103	79527355
Fungal infection	27.28	11.34	16	125914	41732	79576726
Blood pressure decreased	27.15	11.34	258	125672	99208	79519250
Cardiovascular disorder	27.11	11.34	76	125854	17949	79600509
Serotonin syndrome	27.04	11.34	19	125911	45008	79573450
Left ventricular enlargement	26.92	11.34	16	125914	730	79617728
Cholestatic liver injury	26.85	11.34	36	125894	4905	79613553
Sudden cardiac death	26.78	11.34	37	125893	5188	79613270
Tooth erosion	26.70	11.34	13	125917	395	79618063
Neurotoxicity	26.69	11.34	9	125921	32509	79585949
Infection	26.40	11.34	249	125681	241463	79376995
Left ventricular hypertrophy	26.27	11.34	56	125874	11135	79607323
Mucosal haemorrhage	26.21	11.34	26	125904	2560	79615898
Drug withdrawal syndrome	26.16	11.34	11	125919	34707	79583751
Pericardial effusion	26.16	11.34	143	125787	46094	79572364
Gastroenteritis clostridial	26.13	11.34	17	125913	911	79617547
Joint range of motion decreased	25.97	11.34	10	125920	33272	79585186
Skin haemorrhage	25.90	11.34	58	125872	11923	79606535
Oral pain	25.75	11.34	9	125921	31789	79586669
Subdural haematoma	25.61	11.34	108	125822	31326	79587132
Ear pain	25.44	11.34	10	125920	32859	79585599
Coronavirus test positive	25.40	11.34	18	125912	1111	79617347
Urogenital haemorrhage	25.34	11.34	17	125913	960	79617498
Hepatitis E antibody positive	25.26	11.34	11	125919	257	79618201
Spinal pain	25.25	11.34	67	125863	15325	79603133
Vascular compression	25.23	11.34	14	125916	560	79617898
Arteriosclerotic gangrene	25.22	11.34	8	125922	73	79618385
Emotional distress	25.17	11.34	16	125914	39953	79578505
Illness	24.94	11.34	22	125908	46489	79571969
Palisaded neutrophilic granulomatous dermatitis	24.92	11.34	5	125925	3	79618455
Liver injury	24.54	11.34	32	125898	56582	79561876
Crush syndrome	24.49	11.34	10	125920	198	79618260
C-reactive protein increased	24.31	11.34	311	125619	128716	79489742
Ear infection	24.25	11.34	12	125918	34420	79584038
Throat tightness	24.20	11.34	7	125923	27900	79590558
Hepatitis E virus test positive	24.18	11.34	11	125919	286	79618172
Psychotic disorder	24.17	11.34	18	125912	41384	79577074
Rectal prolapse	24.15	11.34	23	125907	2155	79616303
Pulmonary vein occlusion	24.03	11.34	9	125921	140	79618318
Eye injury	23.93	11.34	25	125905	2618	79615840
Carotid arteriosclerosis	23.83	11.34	25	125905	2631	79615827
Oral herpes	23.60	11.34	7	125923	27447	79591011
Disease recurrence	23.49	11.34	21	125909	44088	79574370
Suicide attempt	23.38	11.34	61	125869	82871	79535587
Gout	23.34	11.34	89	125841	24660	79593798
Anal haemorrhage	23.24	11.34	31	125899	4203	79614255
Post-traumatic amnestic disorder	23.21	11.34	7	125923	53	79618405
Poor quality sleep	23.11	11.34	4	125926	22718	79595740
Seroma	23.08	11.34	23	125907	2277	79616181
Road traffic accident	23.00	11.34	21	125909	43643	79574815
Left ventricular dysfunction	22.88	11.34	75	125855	19286	79599172
Rhonchi	22.85	11.34	30	125900	4006	79614452
Adrenal cyst	22.83	11.34	9	125921	162	79618296
Arteriosclerosis	22.81	11.34	72	125858	18155	79600303
Skin ulcer	22.72	11.34	155	125775	53995	79564463
Rash erythematous	22.71	11.34	35	125895	57734	79560724
Irritability	22.62	11.34	19	125911	41125	79577333
Haemothorax	22.57	11.34	35	125895	5443	79613015
Throat irritation	22.40	11.34	19	125911	40927	79577531
Atrioventricular block first degree	22.16	11.34	56	125874	12435	79606023
Vision blurred	22.12	11.34	89	125841	105809	79512649
Stenosis	22.09	11.34	23	125907	2399	79616059
Pneumothorax traumatic	22.05	11.34	10	125920	258	79618200
Grip strength decreased	21.92	11.34	4	125926	21865	79596593
Hyperthyroidism	21.88	11.34	81	125849	22128	79596330
Normocytic anaemia	21.87	11.34	30	125900	4177	79614281
Haemophagocytic lymphohistiocytosis	21.87	11.34	4	125926	21833	79596625
Hepatic calcification	21.82	11.34	11	125919	361	79618097
Labelled drug-drug interaction issue	21.81	11.34	18	125912	1395	79617063
Activated partial thromboplastin time shortened	21.79	11.34	15	125915	884	79617574
Bursitis	21.69	11.34	15	125915	35829	79582629
Renal artery stenosis	21.47	11.34	27	125903	3455	79615003
Amnesia	21.33	11.34	42	125888	63015	79555443
International normalised ratio abnormal	21.23	11.34	35	125895	5733	79612725
Lymphadenopathy	21.18	11.34	32	125898	53215	79565243
Hepatic cyst	21.14	11.34	36	125894	6053	79612405
Cardiovascular somatic symptom disorder	21.10	11.34	6	125924	36	79618422
Cachexia	21.05	11.34	51	125879	11032	79607426
Haemarthrosis	21.03	11.34	35	125895	5777	79612681
Administration site discomfort	20.93	11.34	8	125922	132	79618326
Testicular swelling	20.88	11.34	17	125913	1293	79617165
Hot flush	20.86	11.34	34	125896	54843	79563615
Heat stroke	20.84	11.34	19	125911	1684	79616774
Cytomegalovirus infection	20.74	11.34	22	125908	42622	79575836
Fracture blisters	20.73	11.34	7	125923	79	79618379
Drug reaction with eosinophilia and systemic symptoms	20.71	11.34	44	125886	64200	79554258
Spontaneous haemorrhage	20.67	11.34	14	125916	803	79617655
Articular calcification	20.64	11.34	9	125921	211	79618247
Pulmonary mass	20.63	11.34	10	125920	29024	79589434
Anaphylactic shock	20.57	11.34	16	125914	35980	79582478
Contusion	20.48	11.34	144	125786	148632	79469826
Accidental exposure to product	20.47	11.34	12	125918	31310	79587148
Appendicitis	20.42	11.34	4	125926	20790	79597668
Polyserositis	20.41	11.34	13	125917	672	79617786
Mitral valve thickening	20.39	11.34	11	125919	416	79618042
Neuroleptic malignant syndrome	20.34	11.34	9	125921	27550	79590908
Traumatic haemothorax	20.30	11.34	12	125918	542	79617916
Body temperature decreased	20.06	11.34	13	125917	32132	79586326
Gangrene	20.06	11.34	44	125886	8920	79609538
Bone marrow failure	20.06	11.34	31	125899	51076	79567382
Sinus rhythm	20.05	11.34	14	125916	844	79617614
Actinic keratosis	20.03	11.34	35	125895	6007	79612451
Scrotal oedema	20.02	11.34	18	125912	1567	79616891
Small intestinal obstruction	19.98	11.34	9	125921	27263	79591195
Coronary artery disease	19.98	11.34	174	125756	65300	79553158
Skin pressure mark	19.98	11.34	7	125923	89	79618369
Femoral artery dissection	19.95	11.34	6	125924	45	79618413
Glomerular filtration rate increased	19.90	11.34	16	125914	1195	79617263
Tooth infection	19.86	11.34	3	125927	18829	79599629
Immunodeficiency	19.74	11.34	5	125925	21763	79596695
Thrombin time prolonged	19.73	11.34	10	125920	332	79618126
Left ventricular false tendon	19.61	11.34	6	125924	48	79618410
Heart rate decreased	19.61	11.34	52	125878	70264	79548194
Withdrawal syndrome	19.46	11.34	9	125921	26845	79591613
Presyncope	19.35	11.34	121	125809	40933	79577525
Dystonia	19.24	11.34	5	125925	21394	79597064
Immature granulocyte count increased	19.12	11.34	12	125918	604	79617854
Colitis	19.11	11.34	56	125874	73251	79545207
Neuroglycopenia	19.10	11.34	11	125919	473	79617985
Diabetic foot	19.03	11.34	26	125904	3606	79614852
Fluid intake reduced	19.03	11.34	35	125895	6253	79612205
Herpes zoster	18.96	11.34	79	125851	93004	79525454
Helplessness	18.93	11.34	10	125920	362	79618096
Hypertensive heart disease	18.93	11.34	28	125902	4178	79614280
Costal cartilage fracture	18.91	11.34	9	125921	260	79618198
Respiratory depression	18.91	11.34	10	125920	27620	79590838
Poor venous access	18.89	11.34	3	125927	18146	79600312
Tendonitis	18.86	11.34	7	125923	23823	79594635
Chronic coronary syndrome	18.75	11.34	7	125923	108	79618350
Hepatorenal syndrome	18.71	11.34	28	125902	4221	79614237
Eye pain	18.71	11.34	19	125911	37559	79580899
Red blood cell sedimentation rate abnormal	18.66	11.34	5	125925	20958	79597500
Injection site rash	18.62	11.34	3	125927	17951	79600507
Blood 25-hydroxycholecalciferol decreased	18.51	11.34	10	125920	379	79618079
Diverticulum intestinal haemorrhagic	18.48	11.34	27	125903	3984	79614474
Mouth ulceration	18.46	11.34	20	125910	38374	79580084
Gait inability	18.45	11.34	41	125889	58876	79559582
Acne	18.37	11.34	10	125920	27180	79591278
Blood glucose abnormal	18.36	11.34	47	125883	10519	79607939
Muscle spasms	18.23	11.34	182	125748	174548	79443910
Biopsy skin abnormal	18.21	11.34	8	125922	191	79618267
Systolic dysfunction	18.15	11.34	26	125904	3769	79614689
Swelling face	18.13	11.34	55	125875	71157	79547301
Iron deficiency	18.11	11.34	47	125883	10607	79607851
Ketoacidosis	18.09	11.34	39	125891	7815	79610643
Aggression	18.06	11.34	33	125897	50925	79567533
Paraesthesia oral	18.00	11.34	5	125925	20466	79597992
Encephalopathy	17.92	11.34	51	125879	67346	79551112
Pneumocystis jirovecii pneumonia	17.89	11.34	15	125915	32493	79585965
Crying	17.85	11.34	7	125923	23036	79595422
Asthenia	17.83	11.34	983	124947	510706	79107752
Akinesia	17.80	11.34	24	125906	3288	79615170
Portal hypertensive gastropathy	17.74	11.34	16	125914	1398	79617060
Drug dependence	17.71	11.34	23	125907	40746	79577712
Weight increased	17.68	11.34	568	125362	276818	79341640
Diastolic dysfunction	17.67	11.34	47	125883	10764	79607694
Inflammation	17.62	11.34	82	125848	93671	79524787
Thirst decreased	17.61	11.34	9	125921	304	79618154
Benign prostatic hyperplasia	17.50	11.34	49	125881	11563	79606895
Musculoskeletal disorder	17.49	11.34	6	125924	21442	79597016
Catheterisation cardiac	17.48	11.34	32	125898	5696	79612762
Subgaleal haematoma	17.46	11.34	7	125923	132	79618326
Jaundice	17.45	11.34	144	125786	53205	79565253
Basal ganglia haemorrhage	17.31	11.34	17	125913	1654	79616804
Lung disorder	17.27	11.34	67	125863	80490	79537968
Thoracic haemorrhage	17.24	11.34	8	125922	218	79618240
Myelosuppression	17.24	11.34	23	125907	40273	79578185
Chest wall haematoma	17.17	11.34	10	125920	439	79618019
Hip fracture	17.16	11.34	14	125916	30747	79587711
Agitation	17.14	11.34	90	125840	99625	79518833
Haemorrhagic erosive gastritis	17.13	11.34	12	125918	727	79617731
Craniocerebral injury	17.10	11.34	30	125900	5166	79613292
Uveitis	17.04	11.34	3	125927	16827	79601631
Impaired work ability	16.95	11.34	5	125925	19676	79598782
Skin infection	16.92	11.34	4	125926	18241	79600217
Overdose	16.76	11.34	198	125732	184008	79434450
Pulpitis dental	16.76	11.34	15	125915	1298	79617160
Eye disorder	16.73	11.34	8	125922	23404	79595054
Palpitations	16.71	11.34	287	125643	126323	79492135
Non-compaction cardiomyopathy	16.45	11.34	5	125925	39	79618419
Injection site haemorrhage	16.42	11.34	12	125918	27858	79590600
Photophobia	16.30	11.34	6	125924	20522	79597936
Pleurothotonus	16.30	11.34	20	125910	2496	79615962
Inappropriate schedule of product administration	16.19	11.34	134	125796	133494	79484964
Mental impairment	16.10	11.34	5	125925	19031	79599427
Upper respiratory tract irritation	16.08	11.34	8	125922	255	79618203
Intestinal haemorrhage	16.07	11.34	33	125897	6393	79612065
Foot deformity	16.05	11.34	9	125921	24065	79594393
Suspected transmission of an infectious agent via product	16.04	11.34	14	125916	1172	79617286
Urinary incontinence	15.93	11.34	115	125815	40794	79577664
Nocturnal dyspnoea	15.84	11.34	16	125914	1610	79616848
Hyperventilation	15.71	11.34	37	125893	7862	79610596
Cyanosis	15.69	11.34	80	125850	25102	79593356
Myoglobin blood increased	15.68	11.34	22	125908	3129	79615329
Oliguria	15.67	11.34	59	125871	16250	79602208
Inferior vena cava syndrome	15.59	11.34	6	125924	101	79618357
Mood swings	15.47	11.34	6	125924	19874	79598584
Disability	15.39	11.34	4	125926	17116	79601342
Gastric disorder	15.37	11.34	22	125908	37411	79581047
Multiple drug therapy	15.35	11.34	25	125905	4053	79614405
Adrenomegaly	15.32	11.34	9	125921	402	79618056
Diabetic nephropathy	15.30	11.34	21	125909	2926	79615532
Hepatic cirrhosis	15.29	11.34	101	125829	34805	79583653
Nervous system disorder	15.26	11.34	12	125918	26844	79591614
Accidental overdose	15.26	11.34	111	125819	39470	79578988
Paraparesis	15.26	11.34	24	125906	3779	79614679
Tenosynovitis	15.26	11.34	3	125927	15551	79602907
Subarachnoid haematoma	15.21	11.34	8	125922	287	79618171
Ventricular assist device insertion	15.18	11.34	5	125925	52	79618406
Dysphonia	15.15	11.34	43	125887	56829	79561629
No adverse event	15.14	11.34	22	125908	37170	79581288
Blood cholesterol decreased	15.05	11.34	16	125914	1709	79616749
Insulin autoimmune syndrome	14.90	11.34	9	125921	423	79618035
Paranoia	14.90	11.34	6	125924	19426	79599032
Alanine aminotransferase decreased	14.90	11.34	15	125915	1504	79616954
Nephrogenic anaemia	14.80	11.34	24	125906	3878	79614580
Tuberculosis	14.76	11.34	3	125927	15195	79603263
Eye pruritus	14.74	11.34	7	125923	20563	79597895
Cerebral ischaemia	14.73	11.34	45	125885	11150	79607308
Colitis ulcerative	14.69	11.34	20	125910	34722	79583736
Frequent bowel movements	14.63	11.34	15	125915	29524	79588934
Cardiomegaly	14.57	11.34	81	125849	26271	79592187
Micturition frequency decreased	14.53	11.34	12	125918	931	79617527
Cerebral haemorrhage	14.46	11.34	147	125783	57526	79560932
Personality change	14.44	11.34	42	125888	10128	79608330
Apnoea	14.43	11.34	46	125884	11658	79606800
Nocturia	14.41	11.34	51	125879	13630	79604828
Acute respiratory distress syndrome	14.35	11.34	30	125900	44037	79574421
Neuralgia	14.33	11.34	19	125911	33365	79585093
Mucosal inflammation	14.26	11.34	66	125864	75514	79542944
Viral infection	14.25	11.34	29	125901	42987	79575471
Rectal haemorrhage	14.18	11.34	67	125863	76233	79542225
Neck pain	14.15	11.34	66	125864	75351	79543107
Painful respiration	14.14	11.34	22	125908	3431	79615027
Pneumonitis	14.11	11.34	49	125881	60811	79557647
Skin turgor decreased	14.09	11.34	11	125919	787	79617671
Normochromic normocytic anaemia	14.09	11.34	35	125895	7692	79610766
Cough	14.04	11.34	711	125219	366078	79252380
Dry gangrene	14.03	11.34	12	125918	977	79617481
Vitamin B6 deficiency	14.02	11.34	8	125922	338	79618120
Dysdiadochokinesis	14.00	11.34	8	125922	339	79618119
Ischaemic stroke	14.00	11.34	95	125835	33036	79585422
Middle insomnia	13.99	11.34	4	125926	16065	79602393
Respiratory tract congestion	13.98	11.34	7	125923	19947	79598511
Neoplasm malignant	13.76	11.34	18	125912	31792	79586666
Tinnitus	13.76	11.34	31	125899	44302	79574156
Skin exfoliation	13.71	11.34	43	125887	55057	79563401
Benign gastrointestinal neoplasm	13.67	11.34	6	125924	143	79618315
Antidiuretic hormone abnormality	13.52	11.34	5	125925	75	79618383
Bladder cancer	13.46	11.34	7	125923	19519	79598939
Psychomotor retardation	13.44	11.34	30	125900	6154	79612304
Sinus arrest	13.36	11.34	22	125908	3600	79614858
Dyskinesia	13.34	11.34	32	125898	44741	79573717
Diabetic neuropathy	13.33	11.34	30	125900	6186	79612272
Spinal cord injury cauda equina	13.33	11.34	6	125924	152	79618306
Macroangiopathy	13.26	11.34	6	125924	154	79618304
Prostate cancer	13.23	11.34	20	125910	33248	79585210
Hypertensive emergency	13.20	11.34	19	125911	2766	79615692
Sciatica	13.18	11.34	20	125910	33202	79585256
Blood pressure diastolic decreased	13.18	11.34	17	125913	30199	79588259
Blood pressure systolic decreased	13.17	11.34	43	125887	11033	79607425
Sinus node dysfunction	13.12	11.34	34	125896	7667	79610791
Eczema	13.12	11.34	28	125902	40790	79577668
Joint effusion	13.11	11.34	6	125924	18008	79600450
Supraventricular extrasystoles	13.11	11.34	32	125898	6955	79611503
Tongue disorder	13.08	11.34	3	125927	13972	79604486
Prerenal failure	13.02	11.34	22	125908	3676	79614782
Deep vein thrombosis	13.01	11.34	125	125805	120794	79497664
Peripheral artery stenosis	12.96	11.34	13	125917	1298	79617160
Plasma cell myeloma	12.95	11.34	42	125888	53217	79565241
Product quality issue	12.93	11.34	21	125909	33919	79584539
Product substitution issue	12.90	11.34	8	125922	20248	79598210
Immune reconstitution inflammatory syndrome	12.90	11.34	3	125927	13838	79604620
Spinal osteoarthritis	12.90	11.34	57	125873	16870	79601588
Sprue-like enteropathy	12.90	11.34	13	125917	1305	79617153
Papillary renal cell carcinoma	12.89	11.34	7	125923	268	79618190
Disseminated intravascular coagulation	12.89	11.34	23	125907	35819	79582639
Flushing	12.86	11.34	84	125846	88184	79530274
Subclavian artery occlusion	12.78	11.34	6	125924	168	79618290
Breast cancer	12.77	11.34	21	125909	33760	79584698
Blood test abnormal	12.73	11.34	6	125924	17704	79600754
Genitourinary tract infection	12.66	11.34	7	125923	278	79618180
Urinary retention	12.64	11.34	141	125789	56489	79561969
Acute left ventricular failure	12.63	11.34	15	125915	1809	79616649
Graft versus host disease	12.61	11.34	4	125926	15022	79603436
Wrong product administered	12.59	11.34	37	125893	8975	79609483
Toothache	12.57	11.34	8	125922	19962	79598496
Erythema	12.53	11.34	263	125667	223027	79395431
Right ventricular dysfunction	12.52	11.34	18	125912	2617	79615841
Language disorder	12.50	11.34	20	125910	3194	79615264
Sinus congestion	12.48	11.34	8	125922	19888	79598570
Hyperparathyroidism	12.46	11.34	20	125910	3204	79615254
Mass	12.44	11.34	6	125924	17466	79600992
Tooth abscess	12.44	11.34	5	125925	16205	79602253
Cardiac murmur functional	12.37	11.34	4	125926	39	79618419
Autoimmune colitis	12.33	11.34	14	125916	1609	79616849
Injection site warmth	12.32	11.34	4	125926	14803	79603655
Bladder tamponade	12.32	11.34	9	125921	583	79617875
Pseudomonas infection	12.32	11.34	9	125921	20894	79597564
Iron deficiency anaemia	12.31	11.34	76	125854	25596	79592862
Anticoagulation drug level increased	12.28	11.34	10	125920	761	79617697
Dyspepsia	12.27	11.34	111	125819	108576	79509882
Foot amputation	12.24	11.34	11	125919	957	79617501
Bone density decreased	12.23	11.34	3	125927	13344	79605114
Sneezing	12.23	11.34	8	125922	19675	79598783
Cerebral infarction	12.22	11.34	118	125812	45558	79572900
Respiratory distress	12.20	11.34	49	125881	58290	79560168
Nodule	12.18	11.34	11	125919	22983	79595475
Ocular hyperaemia	12.16	11.34	16	125914	28190	79590268
Potentiating drug interaction	12.12	11.34	36	125894	8783	79609675
Immobile	12.10	11.34	31	125899	6942	79611516
Hemiparesis	12.10	11.34	93	125837	33640	79584818
Femoral neck fracture	12.09	11.34	39	125891	9945	79608513
Cold sweat	12.07	11.34	60	125870	18639	79599819
Urogenital infection bacterial	12.02	11.34	5	125925	104	79618354
Pulmonary fibrosis	12.01	11.34	33	125897	44079	79574379
Somatosensory evoked potentials abnormal	11.98	11.34	6	125924	194	79618264
Cerebral arteriosclerosis	11.96	11.34	10	125920	789	79617669
Transplant rejection	11.94	11.34	8	125922	19429	79599029
Cerebral ventricular rupture	11.92	11.34	8	125922	452	79618006
Vascular encephalopathy	11.91	11.34	9	125921	614	79617844
Blood glucose fluctuation	11.90	11.34	30	125900	6652	79611806
Intervertebral disc degeneration	11.90	11.34	5	125925	15780	79602678
Catheter management	11.86	11.34	21	125909	3642	79614816
Skin fissures	11.86	11.34	3	125927	13070	79605388
Rash macular	11.85	11.34	17	125913	28882	79589576
Varices oesophageal	11.84	11.34	28	125902	5963	79612495
Epstein-Barr virus infection	11.81	11.34	4	125926	14412	79604046
Parotitis	11.80	11.34	17	125913	2477	79615981
Drug level decreased	11.79	11.34	4	125926	14398	79604060
Emotional disorder	11.77	11.34	4	125926	14383	79604075
Impaired quality of life	11.77	11.34	4	125926	14382	79604076
Corynebacterium test positive	11.76	11.34	5	125925	110	79618348
Drug tolerance decreased	11.73	11.34	3	125927	12975	79605483
Abnormal behaviour	11.69	11.34	25	125905	36396	79582062
Metamyelocyte count increased	11.69	11.34	9	125921	631	79617827
Intervertebral disc space narrowing	11.58	11.34	14	125916	1721	79616737
Cardiopulmonary failure	11.56	11.34	30	125900	6771	79611687
Bone pain	11.54	11.34	47	125883	55695	79562763
Paraplegia	11.53	11.34	25	125905	5028	79613430
Swollen tongue	11.48	11.34	32	125898	42538	79575920
Mycobacterium fortuitum infection	11.44	11.34	6	125924	214	79618244
Atheroembolism	11.44	11.34	7	125923	337	79618121
Ventricular remodelling	11.36	11.34	5	125925	120	79618338

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C03CA04	CARDIOVASCULAR SYSTEM DIURETICS HIGH-CEILING DIURETICS Sulfonamides, plain
FDA PE	N0000175366	Increased Diuresis at Loop of Henle
FDA EPC	N0000175590	Loop Diuretic
MeSH PA	D000959	Antihypertensive Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D004232	Diuretics
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D045283	Natriuretic Agents
MeSH PA	D049994	Sodium Potassium Chloride Symporter Inhibitors
CHEBI has role	CHEBI:35674	antihypertensive drugs
CHEBI has role	CHEBI:77608	loop diuretics

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763
Decompensated cardiac failure	indication	195111005
Edema	indication	267038008
Pulmonary Edema due to Chronic Heart Failure	indication
Peripheral Edema due to Chronic Heart Failure	indication
Renal Disease with Edema	indication
Edema due to Hepatic Cirrhosis	indication
Metabolic alkalosis	contraindication	1388004
Anuria	contraindication	2472002	DOID:2983
Cirrhosis of liver	contraindication	19943007	DOID:5082
Hypovolemia	contraindication	28560003
Dehydration	contraindication	34095006
Hyperuricemia	contraindication	35885006	DOID:1920
Hypokalemia	contraindication	43339004
Gout	contraindication	90560007	DOID:13189
Hearing disorder	contraindication	128540005
Hypertriglyceridemia	contraindication	302870006
Ascites	contraindication	389026000
Azotemia	contraindication	445009001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	6.25	acidic
pKa2	6.98	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Solute carrier family 12 member 1	Transporter	Q13621	S12A1_HUMAN	INHIBITOR	IC50	6.40		WOMBAT-PK	CHEMBL

External reference:

ID	Source
4020851	VUID
N0000148359	NUI
D00382	KEGG_DRUG
4020851	VANDF
C0076840	UMLSCUI
CHEBI:9637	CHEBI
CHEMBL1148	ChEMBL_ID
DB00214	DRUGBANK_ID
D000077786	MESH_DESCRIPTOR_UI
41781	PUBCHEM_CID
7312	IUPHAR_LIGAND_ID
3938	INN_ID
W31X2H97FB	UNII
38413	RXNORM
43738	MMSL
5604	MMSL
d03189	MMSL
004414	NDDF
108476002	SNOMEDCT_US
318034005	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0077	TABLET	20 mg	ORAL	ANDA	24 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	0517-0770	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	24 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	0517-0771	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	24 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-5575	TABLET	20 mg	ORAL	ANDA	23 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7997	TABLET	20 mg	ORAL	ANDA	23 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7997	TABLET	20 mg	ORAL	ANDA	23 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7283	TABLET	20 mg	ORAL	ANDA	24 sections
Torsemide	Human Prescription Drug Label	1	23155-871	TABLET	5 mg	ORAL	ANDA	25 sections
Torsemide	Human Prescription Drug Label	1	23155-872	TABLET	10 mg	ORAL	ANDA	25 sections
Torsemide	Human Prescription Drug Label	1	23155-873	TABLET	20 mg	ORAL	ANDA	25 sections
Torsemide	Human Prescription Drug Label	1	23155-874	TABLET	100 mg	ORAL	ANDA	25 sections
Torsemide	Human Prescription Drug Label	1	31722-529	TABLET	5 mg	ORAL	ANDA	24 sections
Torsemide	Human Prescription Drug Label	1	31722-530	TABLET	10 mg	ORAL	ANDA	24 sections
Torsemide	Human Prescription Drug Label	1	31722-531	TABLET	20 mg	ORAL	ANDA	24 sections
Torsemide	Human Prescription Drug Label	1	31722-532	TABLET	100 mg	ORAL	ANDA	24 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	42291-816	TABLET	5 mg	ORAL	ANDA	22 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	42291-816	TABLET	5 mg	ORAL	ANDA	22 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	42291-817	TABLET	10 mg	ORAL	ANDA	22 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	42291-817	TABLET	10 mg	ORAL	ANDA	22 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	42291-818	TABLET	20 mg	ORAL	ANDA	22 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	42291-818	TABLET	20 mg	ORAL	ANDA	22 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	42291-819	TABLET	100 mg	ORAL	ANDA	22 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	42291-819	TABLET	100 mg	ORAL	ANDA	22 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	43353-315	TABLET	20 mg	ORAL	ANDA	24 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	50090-6495	TABLET	100 mg	ORAL	ANDA	22 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	50090-6499	TABLET	20 mg	ORAL	ANDA	22 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	50111-915	TABLET	5 mg	ORAL	ANDA	22 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	50111-916	TABLET	10 mg	ORAL	ANDA	22 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	50111-917	TABLET	20 mg	ORAL	ANDA	22 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	50111-918	TABLET	100 mg	ORAL	ANDA	22 sections