torsemide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
diuretics, furosemide derivatives 2708 56211-40-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • torasemide
  • torsemide
  • toradiur
A pyridine and sulfonamide derivative that acts as a sodium-potassium chloride symporter inhibitor (loop diuretic). It is used for the treatment of EDEMA associated with CONGESTIVE HEART FAILURE; CHRONIC RENAL INSUFFICIENCY; and LIVER DISEASES. It is also used for the management of HYPERTENSION.
  • Molecular weight: 348.42
  • Formula: C16H20N4O3S
  • CLOGP: 3.21
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 100.19
  • ALOGS: -3.77
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
15 mg O
15 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.16 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 20 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 9.56 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 85 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.21 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.53 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.10 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.646 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 8.147 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 7.834 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 2.228 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 10.170 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 15.160 % High 1
herg hERG pIC50 4.462 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 3.404 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 5.224 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 3.440 % High 1
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,ITK,JAK1,MAP3K21,MAPK7,MARK4,NTRK2,PDK2,PDK4,PIK3CB,PIK3CD,PIK3CG,PRKDC,SIK2,SIK3,STK33,TEK,TTK 32
kinase-selectivity-class AXL,CDK9,DYRK1B,GRK2,MAP2K6,MAPK7,PIK3CD,SIK2 8
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 6.339 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 6.194 High 1
mh-clint Mouse hepatocyte intrinsic clearance 13.092 High 1
mppb Mouse plasma protein binding (% unbound) 9.860 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 9.204 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 10.580 % High 1
rat-kpuu-brain Rat brain Kpuu 0.015 % High 1
rh-clint Rat hepatocyte intrinsic clearance 11.066 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 82.420 % High 1
rppb Rat plasma protein binding (% unbound) 5.990 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 701.455 uM High 1

Approvals:

DateAgencyCompanyOrphan
Aug. 23, 1993 FDA MEDA PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 1409.80 12.37 1682 81835 353433 90191497
Product prescribing error 1059.09 12.37 529 82988 29616 90515314
Product monitoring error 884.60 12.37 276 83241 4268 90540662
Cardiac failure 776.45 12.37 709 82808 108787 90436143
Haematochezia 637.63 12.37 526 82991 70387 90474543
Acute kidney injury 606.60 12.37 1070 82447 319317 90225613
Renal impairment 580.15 12.37 594 82923 104827 90440103
Anaemia 534.27 12.37 1071 82446 351731 90193199
Drug ineffective 534.21 12.37 309 83208 1383989 89160941
Dyspnoea 522.59 12.37 1886 81631 879069 89665861
Oedema peripheral 455.28 12.37 836 82681 257079 90287851
Labelled drug-drug interaction medication error 454.05 12.37 236 83281 14346 90530584
Systemic infection 452.11 12.37 169 83348 4606 90540324
Atrial fibrillation 427.81 12.37 570 82947 133041 90411889
Dehydration 407.58 12.37 680 82837 193767 90351163
Syncope 338.74 12.37 508 83009 132155 90412775
Drug interaction 334.70 12.37 767 82750 275686 90269244
Fall 327.34 12.37 1081 82436 480729 90064201
Hyponatraemia 326.29 12.37 501 83016 133037 90411893
Joint swelling 290.42 12.37 56 83461 503244 90041686
Infusion related reaction 286.16 12.37 27 83490 416753 90128177
Systemic lupus erythematosus 278.93 12.37 13 83504 361883 90183047
Synovitis 271.01 12.37 7 83510 329745 90215185
Arthropathy 270.32 12.37 17 83500 366225 90178705
Bradycardia 267.11 12.37 357 83160 83490 90461440
Hypotension 266.91 12.37 780 82737 324617 90220313
Hyperkalaemia 250.20 12.37 304 83213 64660 90480270
Treatment failure 247.70 12.37 7 83510 303921 90241009
Off label use 247.17 12.37 398 83119 1101854 89443076
Arrhythmia 246.28 12.37 246 83271 42086 90502844
Hypokalaemia 243.65 12.37 435 83082 130681 90414249
Drug intolerance 243.42 12.37 57 83460 447534 90097396
Drug hypersensitivity 233.20 12.37 69 83448 463540 90081390
Electrolyte imbalance 229.83 12.37 184 83333 23561 90521369
Rash 223.58 12.37 243 83274 795857 89749073
Therapeutic drug monitoring analysis not performed 222.58 12.37 72 83445 1257 90543673
Hypersensitivity 220.92 12.37 72 83445 454605 90090325
Blood creatinine increased 211.39 12.37 354 83163 101032 90443898
Lower respiratory tract infection 211.08 12.37 4 83513 250655 90294275
Pulmonary arterial hypertension 210.01 12.37 182 83335 26005 90518925
Haematemesis 205.47 12.37 201 83316 33525 90511405
Dyspnoea exertional 204.96 12.37 291 83226 71997 90472933
Therapeutic product effect decreased 201.47 12.37 14 83503 277557 90267373
Alopecia 200.68 12.37 103 83414 494968 90049962
Discomfort 195.78 12.37 15 83502 274320 90270610
Helicobacter infection 181.99 12.37 6 83511 226844 90318086
Pericarditis 181.39 12.37 19 83498 270132 90274798
Renal failure 178.00 12.37 381 83136 130626 90414304
Gastrointestinal haemorrhage 176.10 12.37 306 83211 89942 90454988
Maternal exposure during pregnancy 174.86 12.37 57 83460 360006 90184924
Orthostatic intolerance 169.78 12.37 59 83458 1295 90543635
Swelling 168.56 12.37 88 83429 418970 90125960
Pulmonary hypertension 166.97 12.37 201 83316 42322 90502608
Melaena 166.19 12.37 182 83335 34615 90510315
Irritable bowel syndrome 164.61 12.37 6 83511 207442 90337488
Hypervolaemia 162.86 12.37 175 83342 32582 90512348
Rheumatoid arthritis 159.93 12.37 67 83450 362547 90182383
Psoriatic arthropathy 158.71 12.37 14 83503 228321 90316609
Hepatic enzyme increased 152.23 12.37 71 83446 360665 90184265
Glomerular filtration rate decreased 150.78 12.37 125 83392 16807 90528123
Abdominal discomfort 145.97 12.37 135 83382 477193 90067737
Anuria 145.90 12.37 116 83401 14702 90530228
Musculoskeletal stiffness 145.61 12.37 46 83471 296486 90248444
Dizziness 145.14 12.37 984 82533 588300 89956630
Pallor 144.91 12.37 168 83349 33997 90510933
Lactic acidosis 138.40 12.37 200 83317 50263 90494667
Fibromyalgia 137.18 12.37 15 83502 206254 90338676
Fluid retention 134.67 12.37 269 83248 87822 90457108
Product administration error 134.59 12.37 143 83374 26280 90518650
Cardiac failure chronic 133.03 12.37 76 83441 5570 90539360
Blood cholesterol increased 131.29 12.37 18 83499 207994 90336936
Hyperglycaemia 129.68 12.37 195 83322 50775 90494155
Mitral valve incompetence 129.34 12.37 130 83387 22394 90522536
Stomatitis 128.96 12.37 46 83471 274652 90270278
Haematoma 128.50 12.37 169 83348 38879 90506051
Right ventricular failure 127.45 12.37 120 83397 19085 90525845
Sinusitis 126.56 12.37 80 83437 343008 90201922
Tricuspid valve incompetence 125.57 12.37 112 83405 16619 90528311
Pain 125.40 12.37 484 83033 995857 89549073
Chronic kidney disease 123.42 12.37 189 83328 50002 90494928
Urticaria 122.29 12.37 68 83449 312666 90232264
Pleural effusion 120.37 12.37 297 83220 111694 90433236
Pancreatic steatosis 116.02 12.37 47 83470 1595 90543335
Arterial haemorrhage 115.05 12.37 53 83464 2470 90542460
Injury 111.46 12.37 23 83494 197326 90347604
Diverticulum intestinal 110.78 12.37 81 83436 9061 90535869
Cardiac failure congestive 109.53 12.37 265 83252 98429 90446501
Aortic valve stenosis 107.82 12.37 60 83457 4180 90540750
Intentional product use issue 107.60 12.37 33 83484 216859 90328071
Arthralgia 107.20 12.37 364 83153 778158 89766772
Liver injury 107.06 12.37 15 83502 170552 90374378
Blood urea increased 106.91 12.37 136 83381 30277 90514653
Nasopharyngitis 103.55 12.37 134 83383 406970 90137960
Angina pectoris 102.74 12.37 152 83365 39008 90505922
Atrial flutter 101.19 12.37 82 83435 10676 90534254
Product use issue 101.14 12.37 93 83424 329826 90215104
Tachypnoea 100.95 12.37 111 83406 21198 90523732
Electrocardiogram abnormal 100.06 12.37 80 83437 10218 90534712
Tachyarrhythmia 99.33 12.37 62 83455 5344 90539586
Therapeutic product effect incomplete 97.09 12.37 29 83488 193867 90351063
Hypoaesthesia 96.99 12.37 88 83429 314122 90230808
Peripheral circulatory failure 96.72 12.37 41 83476 1563 90543367
Haemoglobin decreased 96.10 12.37 348 83169 161608 90383322
Femoral hernia incarcerated 95.79 12.37 40 83477 1468 90543462
Tachycardia 95.43 12.37 341 83176 157332 90387598
Exposure during pregnancy 94.39 12.37 51 83466 238359 90306571
Contraindicated product administered 93.75 12.37 94 83423 320045 90224885
Wound 93.34 12.37 85 83432 302895 90242035
Coronary artery disease 93.27 12.37 134 83383 33489 90511441
C-reactive protein abnormal 90.76 12.37 7 83510 127422 90417508
Lymphatic fistula 90.28 12.37 38 83479 1423 90543507
Blister 89.23 12.37 63 83454 254935 90289995
Hypoglycaemia 88.96 12.37 198 83319 69650 90475280
Bursitis 86.44 12.37 10 83507 131644 90413286
Type 2 diabetes mellitus 85.67 12.37 40 83477 203204 90341726
Cardiogenic shock 85.34 12.37 109 83408 24359 90520571
Ill-defined disorder 84.98 12.37 32 83485 184859 90360071
Disorientation 83.96 12.37 148 83369 43966 90500964
Eructation 83.95 12.37 74 83443 10808 90534122
Cardiac failure acute 83.90 12.37 77 83440 11852 90533078
Gastrointestinal disorder 82.70 12.37 69 83448 256618 90288312
Joint range of motion decreased 82.65 12.37 13 83504 135630 90409300
Upper gastrointestinal haemorrhage 81.16 12.37 103 83414 22873 90522057
Sleep disorder 80.39 12.37 41 83476 197989 90346941
Dementia 79.63 12.37 104 83413 23757 90521173
Migraine 77.92 12.37 39 83478 190353 90354577
Blood loss anaemia 76.33 12.37 68 83449 10072 90534858
Wound infection pseudomonas 75.43 12.37 37 83480 1986 90542944
Urinary retention 74.92 12.37 129 83388 37615 90507315
Dysuria 74.74 12.37 132 83385 39269 90505661
Haematuria 71.44 12.37 121 83396 34816 90510114
Polyneuropathy 70.37 12.37 88 83429 19253 90525677
Grip strength decreased 69.11 12.37 4 83513 92572 90452358
Haemarthrosis 68.86 12.37 44 83473 3950 90540980
Blood potassium increased 68.56 12.37 90 83427 20659 90524271
Blood cholesterol decreased 68.09 12.37 34 83483 1897 90543033
Ascites 67.27 12.37 141 83376 47599 90497331
Urosepsis 66.94 12.37 90 83427 21142 90523788
Hepatic cyst 65.90 12.37 52 83465 6516 90538414
Faecaloma 65.07 12.37 63 83454 10368 90534562
Hypertensive crisis 64.84 12.37 81 83436 17703 90527227
Restlessness 64.34 12.37 117 83400 35603 90509327
Respiratory failure 64.01 12.37 247 83270 118171 90426759
Hypotonia 63.86 12.37 65 83452 11361 90533569
Seroma 63.66 12.37 38 83479 3022 90541908
Cardiovascular disorder 63.42 12.37 70 83447 13422 90531508
Arthritis 63.05 12.37 38 83479 167277 90377653
Circulatory collapse 62.94 12.37 95 83422 24809 90520121
Malaise 61.68 12.37 304 83213 585682 89959248
Night sweats 61.35 12.37 21 83496 128745 90416185
Erysipelas 60.90 12.37 57 83460 8995 90535935
Psoriasis 60.85 12.37 30 83487 147724 90397206
Gastroenteritis clostridial 60.66 12.37 23 83494 652 90544278
Mobility decreased 60.19 12.37 86 83431 250648 90294282
N-terminal prohormone brain natriuretic peptide increased 59.59 12.37 36 83481 2926 90542004
Injection site pain 58.05 12.37 45 83472 173654 90371276
Product use in unapproved indication 58.01 12.37 141 83376 336095 90208835
Paraesthesia 58.00 12.37 88 83429 250238 90294692
Road traffic accident 57.81 12.37 14 83503 107612 90437318
Epistaxis 57.49 12.37 191 83326 84934 90459996
Completed suicide 57.43 12.37 31 83486 145027 90399903
Gamma-glutamyltransferase increased 56.90 12.37 115 83402 37837 90507093
Truncus arteriosus persistent 56.23 12.37 19 83498 382 90544548
Waist circumference increased 56.17 12.37 24 83493 933 90543997
Hiatus hernia 56.10 12.37 91 83426 25270 90519660
Neuroglycopenia 55.82 12.37 25 83492 1090 90543840
Urinary tract infection 55.66 12.37 476 83041 305156 90239774
Hyperthyroidism 55.27 12.37 76 83441 18234 90526696
Acute respiratory failure 55.02 12.37 122 83395 42796 90502134
Osteoarthritis 54.42 12.37 60 83457 195670 90349260
Peripheral arterial occlusive disease 53.87 12.37 40 83477 4581 90540349
Injection site reaction 53.51 12.37 10 83507 92070 90452860
Parkinsonism 52.79 12.37 65 83452 14000 90530930
Blood uric acid increased 52.77 12.37 49 83468 7655 90537275
Inflammation 52.74 12.37 52 83465 178540 90366390
Asthma 52.45 12.37 89 83428 242071 90302859
Red blood cell sedimentation rate increased 52.44 12.37 7 83510 82588 90462342
Pericardial effusion 50.98 12.37 108 83409 36725 90508205
Gait inability 50.14 12.37 37 83480 146419 90398511
Loss of personal independence in daily activities 49.77 12.37 32 83485 136073 90408857
Constipation 49.64 12.37 434 83083 279961 90264969
Escherichia infection 49.53 12.37 67 83450 15828 90529102
Sciatica 49.23 12.37 16 83501 101366 90443564
Flatulence 49.04 12.37 114 83403 41253 90503677
Inflammatory marker increased 48.94 12.37 51 83466 9163 90535767
Fracture 48.54 12.37 79 83438 21997 90522933
Congenital cardiovascular anomaly 48.51 12.37 18 83499 480 90544450
Pruritus 47.63 12.37 298 83219 541227 90003703
Sepsis 47.52 12.37 306 83211 179508 90365422
Bradyarrhythmia 47.18 12.37 29 83488 2432 90542498
Aortic arteriosclerosis 47.17 12.37 46 83471 7638 90537292
Pulmonary fibrosis 47.10 12.37 20 83497 107483 90437447
Atrioventricular block first degree 46.81 12.37 48 83469 8463 90536467
Wheezing 46.67 12.37 93 83424 237987 90306943
Impaired healing 46.33 12.37 91 83426 234108 90310822
Gastritis 46.18 12.37 112 83405 41641 90503289
Adverse drug reaction 46.11 12.37 25 83492 116676 90428254
Medication error 44.46 12.37 175 83342 84477 90460453
Limb reduction defect 44.45 12.37 18 83499 610 90544320
Contusion 44.38 12.37 104 83413 251112 90293818
Joint stiffness 44.24 12.37 9 83508 78033 90466897
Abdominal pain lower 43.53 12.37 90 83427 30087 90514843
Diastolic dysfunction 43.34 12.37 43 83474 7290 90537640
Therapeutic drug monitoring analysis incorrectly performed 43.30 12.37 15 83502 326 90544604
Prothrombin time prolonged 43.02 12.37 49 83468 9723 90535207
Hip arthroplasty 42.76 12.37 9 83508 76199 90468731
Lung disorder 42.71 12.37 45 83472 149838 90395092
Pregnancy 42.56 12.37 4 83513 62043 90482887
Pulmonary oedema 42.54 12.37 140 83377 61940 90482990
Spinal pain 42.50 12.37 62 83455 15705 90529225
Hypercholesterolaemia 42.28 12.37 20 83497 100872 90444058
Lower limb fracture 42.02 12.37 13 83504 85000 90459930
Wound dehiscence 41.76 12.37 38 83479 5784 90539146
Concomitant disease aggravated 41.26 12.37 52 83465 11466 90533464
Multiple drug therapy 41.24 12.37 41 83476 6968 90537962
Atrioventricular block complete 41.18 12.37 48 83469 9763 90535167
Leukopenia 41.18 12.37 193 83324 100517 90444413
Left ventricular failure 40.92 12.37 40 83477 6660 90538270
Knee arthroplasty 40.61 12.37 13 83504 83169 90461761
Wound infection 40.31 12.37 24 83493 106378 90438552
Therapy non-responder 40.13 12.37 40 83477 136664 90408266
Coagulation test abnormal 39.95 12.37 19 83498 952 90543978
Rhonchi 39.78 12.37 28 83489 2950 90541980
Glomerular filtration rate abnormal 39.67 12.37 21 83496 1324 90543606
Retrograde amnesia 39.63 12.37 16 83501 538 90544392
Blood creatine increased 39.60 12.37 40 83477 6927 90538003
Autoimmune disorder 39.27 12.37 11 83506 76733 90468197
Vascular resistance pulmonary decreased 39.18 12.37 10 83507 70 90544860
Infection 39.11 12.37 186 83331 361908 90183022
Left ventricular dysfunction 38.55 12.37 57 83460 14612 90530318
Adverse event 38.49 12.37 31 83486 117387 90427543
Accidental overdose 38.09 12.37 82 83435 28191 90516739
Insomnia 37.97 12.37 168 83349 333306 90211624
Product used for unknown indication 37.77 12.37 17 83500 750 90544180
Amnesia 37.67 12.37 27 83490 108478 90436452
Live birth 37.51 12.37 13 83504 79094 90465836
Cardiac septal defect 37.39 12.37 17 83500 768 90544162
Limb hypoplasia congenital 37.01 12.37 12 83505 211 90544719
Diverticulum intestinal haemorrhagic 36.98 12.37 22 83495 1739 90543191
Stasis dermatitis 36.94 12.37 18 83499 952 90543978
Gastric polyps 36.50 12.37 32 83485 4640 90540290
Ear pain 36.37 12.37 5 83512 57697 90487233
Disease risk factor 36.10 12.37 12 83505 229 90544701
Product quality issue 35.98 12.37 14 83503 79311 90465619
Internal haemorrhage 35.89 12.37 36 83481 6184 90538746
Thrombocytopenia 35.84 12.37 321 83196 208404 90336526
Anaphylactic reaction 35.68 12.37 18 83499 87506 90457424
Aplastic anaemia 35.51 12.37 52 83465 13217 90531713
Depressed level of consciousness 35.46 12.37 147 83370 72637 90472293
Pulmonary congestion 35.43 12.37 64 83453 19369 90525561
Cerebral haemorrhage 35.43 12.37 90 83427 34432 90510498
International normalised ratio increased 35.42 12.37 110 83407 47206 90497724
Thirst 35.40 12.37 58 83459 16237 90528693
Coronavirus test positive 35.27 12.37 17 83500 878 90544052
Exostosis 34.96 12.37 4 83513 53130 90491800
Cardiorenal syndrome 34.61 12.37 18 83499 1094 90543836
Labelled drug-drug interaction issue 34.35 12.37 23 83494 2235 90542695
Therapeutic response decreased 34.33 12.37 20 83497 89709 90455221
Sprue-like enteropathy 34.25 12.37 17 83500 936 90543994
Bundle branch block right 34.14 12.37 33 83484 5420 90539510
Gout 33.95 12.37 58 83459 16801 90528129
Dry mouth 33.47 12.37 75 83442 183984 90360946
Hypertensive heart disease 33.37 12.37 24 83493 2616 90542314
Blindness transient 33.27 12.37 30 83487 4513 90540417
Bradykinesia 33.26 12.37 36 83481 6752 90538178
Orthopnoea 33.06 12.37 36 83481 6799 90538131
Congenital oral malformation 33.04 12.37 11 83506 211 90544719
Drug clearance decreased 32.95 12.37 21 83496 1877 90543053
Congenital coronary artery malformation 32.38 12.37 10 83507 149 90544781
Stupor 32.13 12.37 32 83485 5450 90539480
Depression 32.10 12.37 155 83362 300446 90244484
Peripheral venous disease 31.69 12.37 19 83498 83902 90461028
Lower gastrointestinal haemorrhage 31.62 12.37 40 83477 8852 90536078
Cerebral ischaemia 31.54 12.37 36 83481 7160 90537770
Drug ineffective for unapproved indication 31.51 12.37 11 83506 66633 90478297
Craniofacial fracture 31.47 12.37 13 83504 464 90544466
Transfusion 31.13 12.37 57 83460 17431 90527499
Injection site erythema 31.06 12.37 27 83490 98475 90446455
Febrile neutropenia 30.90 12.37 62 83455 158287 90386643
Device stimulation issue 30.86 12.37 8 83509 60 90544870
Thrombin time prolonged 30.85 12.37 9 83508 109 90544821
Polyuria 30.80 12.37 42 83475 9998 90534932
Tooth erosion 30.71 12.37 13 83504 494 90544436
Glycosylated haemoglobin increased 30.63 12.37 53 83464 15509 90529421
Hypothermia 30.60 12.37 53 83464 15522 90529408
Left-to-right cardiac shunt 30.46 12.37 11 83506 271 90544659
Coeliac disease 30.27 12.37 3 83514 44607 90500323
Headache 30.23 12.37 587 82930 862159 89682771
Colitis ulcerative 30.17 12.37 9 83508 60257 90484673
Memory impairment 29.99 12.37 88 83429 197156 90347774
Renal function test abnormal 29.88 12.37 35 83482 7156 90537774
Sudden cardiac death 29.85 12.37 21 83496 2211 90542719
Nausea 29.77 12.37 1278 82239 1109038 89435892
Cholestatic liver injury 29.65 12.37 26 83491 3771 90541159
Anxiety 29.56 12.37 166 83351 309606 90235324
Pelvic haematoma 29.13 12.37 14 83503 718 90544212
Spontaneous haemorrhage 29.12 12.37 14 83503 719 90544211
Hyperparathyroidism secondary 28.98 12.37 19 83498 1782 90543148
Onychomadesis 28.96 12.37 4 83513 45994 90498936
Obesity 28.60 12.37 33 83484 105474 90439456
Exercise tolerance decreased 28.50 12.37 35 83482 7516 90537414
Drug-disease interaction 28.49 12.37 15 83502 935 90543995
Cardioversion 28.47 12.37 17 83500 1353 90543577
Duodenitis 28.44 12.37 27 83490 4336 90540594
Painful respiration 28.37 12.37 23 83494 2995 90541935
Prescribed overdose 28.16 12.37 29 83488 97596 90447334
Psychomotor retardation 28.15 12.37 28 83489 4761 90540169
Heart disease congenital 28.02 12.37 18 83499 1631 90543299
Brain natriuretic peptide increased 27.95 12.37 31 83486 5974 90538956
Drug abuse 27.93 12.37 21 83496 82326 90462604
Iron deficiency anaemia 27.81 12.37 65 83452 23597 90521333
Presyncope 27.67 12.37 78 83439 31727 90513203
Frequent bowel movements 27.61 12.37 9 83508 56926 90488004
Ear infection 27.48 12.37 15 83502 69760 90475170
Blood pressure decreased 27.36 12.37 139 83378 74756 90470174
Necrotising fasciitis 27.20 12.37 25 83492 3855 90541075
Polyserositis 27.18 12.37 13 83504 660 90544270
Initial insomnia 27.14 12.37 38 83479 9272 90535658
Palpitations 27.02 12.37 217 83300 136511 90408419
Disability 26.97 12.37 3 83514 40742 90504188
Cerebral infarction 26.94 12.37 69 83448 26527 90518403
Disturbance in attention 26.87 12.37 100 83417 47009 90497921
Haemoptysis 26.38 12.37 79 83438 33241 90511689
Taste disorder 26.09 12.37 12 83505 61534 90483396
Leukocytosis 25.99 12.37 75 83442 30915 90514015
N-terminal prohormone brain natriuretic peptide abnormal 25.97 12.37 7 83510 62 90544868
Groin pain 25.90 12.37 43 83474 12170 90532760
Crush syndrome 25.87 12.37 10 83507 299 90544631
Nail disorder 25.85 12.37 11 83506 59056 90485874
Inappropriate antidiuretic hormone secretion 25.62 12.37 56 83461 19449 90525481
Catheterisation cardiac 25.55 12.37 27 83490 4929 90540001
Hypertensive emergency 25.42 12.37 19 83498 2198 90542732
Biopsy skin abnormal 25.38 12.37 8 83509 128 90544802
Generalised oedema 25.37 12.37 55 83462 18998 90525932
Genital erosion 25.17 12.37 11 83506 452 90544478
Administration site discomfort 25.09 12.37 8 83509 133 90544797
Lupus-like syndrome 24.99 12.37 7 83510 48839 90496091
Fracture blisters 24.95 12.37 7 83510 73 90544857
Sinoatrial block 24.95 12.37 14 83503 991 90543939
Foot deformity 24.72 12.37 12 83505 59639 90485291
Laryngitis 24.65 12.37 8 83509 50745 90494185
Back pain 24.62 12.37 181 83336 316994 90227936
Muscle spasms 24.56 12.37 134 83383 251749 90293181
Dyspnoea at rest 24.52 12.37 26 83491 4765 90540165
Immunodeficiency 24.47 12.37 5 83512 43229 90501701
Subdural haematoma 24.43 12.37 50 83467 16595 90528335
Haemorrhagic erosive gastritis 24.38 12.37 11 83506 488 90544442
Supraventricular extrasystoles 24.23 12.37 27 83490 5230 90539700
Chronic obstructive pulmonary disease 24.21 12.37 133 83384 73696 90471234
Postoperative wound infection 24.20 12.37 44 83473 13382 90531548
Femoral artery dissection 24.16 12.37 6 83511 37 90544893
Onychomycosis 24.13 12.37 3 83514 37373 90507557
Ventricular fibrillation 24.03 12.37 45 83472 13999 90530931
Cleft palate 23.94 12.37 15 83502 1301 90543629
Mucosal erosion 23.84 12.37 17 83500 1828 90543102
Diabetes mellitus inadequate control 23.82 12.37 53 83464 18631 90526299
Pneumothorax traumatic 23.76 12.37 8 83509 159 90544771
Pulmonary vein occlusion 23.69 12.37 7 83510 89 90544841
Upper respiratory tract infection 23.56 12.37 52 83465 128266 90416664
Hyperuricaemia 23.53 12.37 30 83487 6689 90538241
Cardiac arrest 23.21 12.37 171 83346 104764 90440166
Myelodysplastic syndrome 23.03 12.37 56 83461 20847 90524083
Abdominal pain 22.91 12.37 501 83016 395220 90149710
Antineutrophil cytoplasmic antibody positive 22.90 12.37 12 83505 741 90544189
Pelvic venous thrombosis 22.61 12.37 17 83500 1984 90542946
Injection site bruising 22.48 12.37 10 83507 52297 90492633
Helplessness 22.42 12.37 9 83508 298 90544632
Neuropathy peripheral 22.38 12.37 59 83458 136911 90408019
End stage renal disease 22.09 12.37 33 83484 8538 90536392
Bicytopenia 22.08 12.37 22 83495 3749 90541181
Pain in extremity 21.94 12.37 288 83229 450241 90094689
Ventricular septal defect 21.94 12.37 26 83491 5381 90539549
Sinus node dysfunction 21.92 12.37 26 83491 5386 90539544
Pulpitis dental 21.90 12.37 13 83504 1023 90543907
Upper respiratory tract irritation 21.79 12.37 8 83509 207 90544723
Procalcitonin increased 21.58 12.37 15 83502 1549 90543381
Normochromic normocytic anaemia 21.48 12.37 25 83492 5077 90539853
Arteriosclerosis 21.41 12.37 37 83480 10816 90534114
Hypochromic anaemia 21.38 12.37 17 83500 2154 90542776
BRASH syndrome 21.31 12.37 16 83501 1863 90543067
Thirst decreased 21.31 12.37 9 83508 340 90544590
Puncture site haematoma 21.18 12.37 6 83511 65 90544865
Anal haemorrhage 21.16 12.37 18 83499 2506 90542424
Chest wall haematoma 20.96 12.37 8 83509 231 90544699
Dysmorphism 20.89 12.37 18 83499 2550 90542380
Hepatic failure 20.75 12.37 82 83435 39646 90505284
Injection site swelling 20.63 12.37 15 83502 59824 90485106
Talipes 20.61 12.37 15 83502 1665 90543265
Chronic gastritis 20.39 12.37 21 83496 3720 90541210
Antidiuretic hormone abnormality 20.39 12.37 5 83512 29 90544901
Serotonin syndrome 20.20 12.37 5 83512 37882 90507048
Suicidal ideation 20.12 12.37 23 83494 73832 90471098
Retrognathia 20.09 12.37 10 83507 554 90544376
International normalised ratio abnormal 19.91 12.37 21 83496 3824 90541106
Chronic respiratory failure 19.88 12.37 18 83499 2723 90542207
Myocardial infarction 19.75 12.37 166 83351 105806 90439124
Ischaemic cerebral infarction 19.75 12.37 14 83503 1492 90543438
Pain in jaw 19.63 12.37 92 83425 47893 90497037
Transaminases increased 19.61 12.37 77 83440 37115 90507815
Neovascular age-related macular degeneration 19.44 12.37 9 83508 424 90544506
Hypocalcaemia 19.41 12.37 84 83433 42284 90502646
Dry eye 19.35 12.37 15 83502 57916 90487014
Localised oedema 19.13 12.37 26 83491 6168 90538762
Cerebral artery occlusion 19.09 12.37 12 83505 1047 90543883
Cardiomegaly 19.07 12.37 49 83468 18876 90526054
Abdominal distension 19.01 12.37 194 83323 130407 90414523
Dyspepsia 18.99 12.37 106 83411 198054 90346876
Catheter site haemorrhage 18.94 12.37 20 83497 3648 90541282
Dry gangrene 18.82 12.37 10 83507 635 90544295
Atrial thrombosis 18.80 12.37 16 83501 2229 90542701
Post procedural haematuria 18.68 12.37 5 83512 43 90544887
Ischaemic cardiomyopathy 18.64 12.37 17 83500 2596 90542334
Diabetic neuropathy 18.57 12.37 22 83495 4552 90540378
Escherichia urinary tract infection 18.53 12.37 40 83477 13775 90531155
Fear of falling 18.51 12.37 10 83507 657 90544273
Ventricular extrasystoles 18.51 12.37 39 83478 13211 90531719
Language disorder 18.42 12.37 17 83500 2635 90542295
Shock haemorrhagic 18.23 12.37 37 83480 12208 90532722
Red cell distribution width abnormal 18.22 12.37 7 83510 206 90544724
Gastrooesophageal reflux disease 18.19 12.37 85 83432 166252 90378678
Death 18.19 12.37 550 82967 456001 90088929
Vascular graft infection 18.19 12.37 5 83512 48 90544882
Rheumatoid arthritis-associated interstitial lung disease 18.14 12.37 8 83509 336 90544594
Agranulocytosis 18.08 12.37 72 83445 34930 90510000
Sinus arrhythmia 17.92 12.37 13 83504 1436 90543494
Injection site pruritus 17.91 12.37 14 83503 53820 90491110
Oropharyngeal pain 17.78 12.37 51 83466 115136 90429794
Femoral neck fracture 17.77 12.37 33 83484 10200 90534730
Electrocardiogram QT prolonged 17.73 12.37 121 83396 72335 90472595
Hepatocellular carcinoma 17.71 12.37 16 83501 2412 90542518
Toxic epidermal necrolysis 17.69 12.37 68 83449 32460 90512470
Toxoplasmosis 17.63 12.37 14 83503 1771 90543159
Liver function test increased 17.62 12.37 32 83485 84823 90460107
Decreased appetite 17.61 12.37 463 83054 376077 90168853
Prerenal failure 17.56 12.37 15 83502 2100 90542830
Intentional product misuse 17.55 12.37 35 83482 89569 90455361
Vomiting 17.54 12.37 891 82626 787402 89757528
Sensorimotor disorder 17.35 12.37 10 83507 745 90544185
Atrioventricular block 17.32 12.37 30 83487 8785 90536145
Pelvi-ureteric obstruction 17.22 12.37 8 83509 380 90544550
Cyanosis 17.21 12.37 48 83469 19407 90525523
Rash pruritic 17.07 12.37 31 83486 82183 90462747
Ischaemic stroke 17.02 12.37 52 83465 22114 90522816
Hyperphosphataemia 17.00 12.37 19 83498 3692 90541238
Developmental hip dysplasia 16.88 12.37 13 83504 1572 90543358
Muscle haemorrhage 16.84 12.37 18 83499 3328 90541602
Oral papilloma 16.82 12.37 5 83512 65 90544865
Respiratory disorder 16.79 12.37 21 83496 64795 90480135
Blindness cortical 16.73 12.37 9 83508 586 90544344
No adverse event 16.61 12.37 23 83494 67959 90476971
Muscle rigidity 16.48 12.37 39 83478 14270 90530660
Brain natriuretic peptide abnormal 16.47 12.37 8 83509 420 90544510
Muscle spasticity 16.41 12.37 6 83511 35316 90509614
Mitral valve stenosis 16.37 12.37 12 83505 1347 90543583
Coma 16.36 12.37 26 83491 72606 90472324
Ventricular tachycardia 16.28 12.37 55 83462 24653 90520277
Herbal interaction 16.20 12.37 6 83511 159 90544771
Ventricular assist device insertion 16.06 12.37 4 83513 25 90544905
HCoV-HKU1 infection 16.06 12.37 4 83513 25 90544905
Gastritis erosive 15.99 12.37 25 83492 6730 90538200
Reactive gastropathy 15.94 12.37 9 83508 645 90544285
Folate deficiency 15.89 12.37 17 83500 3148 90541782
Aplasia 15.88 12.37 19 83498 3972 90540958
Acute myocardial infarction 15.85 12.37 69 83448 34821 90510109
Multiple sclerosis relapse 15.70 12.37 15 83502 52290 90492640
Cardiac hypertrophy 15.56 12.37 11 83506 1167 90543763
Throat tightness 15.51 12.37 4 83513 29480 90515450
Iron deficiency 15.46 12.37 30 83487 9582 90535348
Haemoglobin increased 15.41 12.37 26 83491 7455 90537475
Low density lipoprotein abnormal 15.30 12.37 7 83510 321 90544609
Aggression 15.27 12.37 3 83514 26665 90518265
Ketoacidosis 15.08 12.37 22 83495 5573 90539357
Blood potassium decreased 15.00 12.37 85 83432 47642 90497288
Optic nerve disorder 14.91 12.37 11 83506 1247 90543683
Concomitant disease progression 14.91 12.37 14 83503 2218 90542712
Left ventricular hypertrophy 14.90 12.37 23 83494 6121 90538809
Atrial septal defect 14.86 12.37 27 83490 8207 90536723
Haematocrit decreased 14.83 12.37 77 83440 41755 90503175
Periodontitis 14.77 12.37 18 83499 3835 90541095
Obstructive airways disorder 14.62 12.37 3 83514 25866 90519064
Acute left ventricular failure 14.62 12.37 11 83506 1285 90543645
Activated partial thromboplastin time prolonged 14.56 12.37 26 83491 7799 90537131
Aspartate aminotransferase increased 14.54 12.37 152 83365 102785 90442145
Rhinorrhoea 14.46 12.37 38 83479 88278 90456652
Haemorrhoidal haemorrhage 14.45 12.37 21 83496 5302 90539628
Drug resistance 14.44 12.37 5 83512 30444 90514486
Sleep disorder due to a general medical condition 14.42 12.37 12 83505 44726 90500204
Cardiac murmur functional 14.41 12.37 4 83513 40 90544890
Cardiac pacemaker insertion 14.38 12.37 19 83498 4388 90540542
Asthenia 14.36 12.37 615 82902 533136 90011794
Right atrial enlargement 14.35 12.37 6 83511 221 90544709
Cachexia 14.30 12.37 24 83493 6854 90538076
Dialysis 14.29 12.37 32 83485 11297 90533633
Periorbital haematoma 14.14 12.37 9 83508 802 90544128
Prescribed underdose 14.10 12.37 30 83487 74989 90469941
Puncture site haemorrhage 14.01 12.37 7 83510 391 90544539
Right aortic arch 13.98 12.37 6 83511 236 90544694
Inappropriate schedule of product administration 13.93 12.37 81 83436 149852 90395078
Alcoholic liver disease 13.93 12.37 5 83512 121 90544809
Glomerular filtration rate increased 13.91 12.37 13 83504 2047 90542883
Cor pulmonale 13.91 12.37 13 83504 2047 90542883
Microangiopathy 13.91 12.37 12 83505 1703 90543227
Humerus fracture 13.90 12.37 29 83488 9756 90535174
Pulmonary arterial wedge pressure increased 13.81 12.37 7 83510 403 90544527
Hypoxia 13.80 12.37 114 83403 72285 90472645
Pulse absent 13.76 12.37 22 83495 6033 90538897
Ecthyma 13.75 12.37 7 83510 407 90544523
Dysphagia 13.67 12.37 161 83356 112117 90432813
Left ventricular end-diastolic pressure increased 13.64 12.37 7 83510 414 90544516
Craniocerebral injury 13.62 12.37 16 83501 3282 90541648
Mucosal haemorrhage 13.51 12.37 11 83506 1442 90543488
Localised infection 13.48 12.37 64 83453 33498 90511432
Polydipsia 13.43 12.37 18 83499 4213 90540717
Gastritis haemorrhagic 13.41 12.37 12 83505 1788 90543142
Procedural pain 13.39 12.37 7 83510 33353 90511577
Diet noncompliance 13.35 12.37 7 83510 433 90544497
Stress 13.34 12.37 35 83482 81360 90463570
Alanine aminotransferase decreased 13.32 12.37 9 83508 888 90544042
Varicose vein ruptured 13.32 12.37 4 83513 54 90544876
Renal artery stenosis 13.30 12.37 13 83504 2164 90542766
Microcytic anaemia 13.30 12.37 17 83500 3801 90541129
Dizziness postural 13.06 12.37 27 83490 9026 90535904
Peripheral artery occlusion 13.03 12.37 11 83506 1515 90543415
Lip erosion 12.85 12.37 10 83507 1228 90543702
Retroperitoneal haemorrhage 12.81 12.37 15 83502 3065 90541865
Deep vein thrombosis 12.81 12.37 135 83382 91485 90453445
Eastern Cooperative Oncology Group performance status worsened 12.64 12.37 12 83505 1927 90543003
Activated partial thromboplastin time shortened 12.59 12.37 7 83510 487 90544443
Septic encephalopathy 12.56 12.37 5 83512 162 90544768
Drug tolerance decreased 12.52 12.37 7 83510 32123 90512807
Blood albumin decreased 12.51 12.37 39 83478 16764 90528166
Device related infection 12.49 12.37 52 83465 25734 90519196
Gallbladder empyema 12.46 12.37 4 83513 68 90544862
Osteopenia 12.43 12.37 48 83469 22954 90521976
Right ventricular dysfunction 12.40 12.37 13 83504 2351 90542579
Abdominal wall haemorrhage 12.39 12.37 5 83512 168 90544762
Cardiovascular insufficiency 12.38 12.37 11 83506 1624 90543306

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 1644.74 12.01 1700 77992 149546 42392097
Cardiac failure 762.96 12.01 968 78724 105888 42435755
Oedema peripheral 737.17 12.01 1078 78614 134998 42406645
Product monitoring error 494.01 12.01 215 79477 4208 42537435
Dyspnoea 446.54 12.01 1818 77874 440803 42100840
Product prescribing error 443.10 12.01 377 79315 25735 42515908
Drug ineffective 434.17 12.01 329 79363 629868 41911775
Haematochezia 370.65 12.01 500 79192 57936 42483707
Systemic infection 331.89 12.01 172 79520 5033 42536610
Cardiac failure chronic 312.41 12.01 205 79487 9396 42532247
Off label use 296.45 12.01 462 79230 637873 41903770
Anaemia 270.88 12.01 1138 78554 279140 42262503
Atrial fibrillation 239.05 12.01 686 79006 138907 42402736
Syncope 220.45 12.01 538 79154 98868 42442775
Electrocardiogram abnormal 219.73 12.01 169 79523 9976 42531667
Electrolyte imbalance 213.67 12.01 208 79484 16893 42524750
Dizziness 197.70 12.01 955 78737 248299 42293344
Dyspnoea exertional 186.98 12.01 336 79356 49812 42491831
Renal impairment 182.12 12.01 535 79157 109693 42431950
Bradycardia 169.97 12.01 444 79248 85040 42456603
Labelled drug-drug interaction medication error 160.89 12.01 171 79521 15411 42526232
N-terminal prohormone brain natriuretic peptide increased 156.27 12.01 91 79601 3362 42538281
Acute kidney injury 153.04 12.01 1191 78501 366146 42175497
Angina pectoris 144.39 12.01 237 79455 32659 42508984
Exercise tolerance decreased 140.07 12.01 105 79587 5961 42535682
Glomerular filtration rate decreased 138.82 12.01 162 79530 16189 42525454
Toxicity to various agents 126.85 12.01 145 79547 228991 42312652
Haematoma 124.48 12.01 203 79489 27820 42513823
Dehydration 123.71 12.01 559 79133 141208 42400435
Therapeutic drug monitoring analysis not performed 123.60 12.01 45 79647 537 42541106
Arrhythmia 121.71 12.01 247 79445 40070 42501573
Febrile neutropenia 115.82 12.01 106 79586 185597 42356046
Ventricular arrhythmia 115.42 12.01 95 79597 6184 42535459
Drug abuse 113.60 12.01 28 79664 104743 42436900
Hypokalaemia 113.50 12.01 343 79349 71378 42470265
Inferior vena cava dilatation 112.00 12.01 46 79646 774 42540869
Neutropenia 111.66 12.01 125 79567 199306 42342337
Fall 109.63 12.01 782 78910 233738 42307905
Hypotension 109.61 12.01 840 78852 256791 42284852
Dyspnoea at rest 108.14 12.01 78 79614 4171 42537472
Ventricular enlargement 106.00 12.01 42 79650 641 42541002
Pallor 105.65 12.01 192 79500 28694 42512949
Ejection fraction decreased 104.94 12.01 165 79527 21922 42519721
Rash 102.52 12.01 229 79463 276725 42264918
Hyperkalaemia 101.36 12.01 356 79336 80102 42461541
Melaena 99.19 12.01 222 79470 38524 42503119
Pulmonary hypertension 91.76 12.01 161 79531 23408 42518235
Right ventricular failure 88.42 12.01 99 79593 9456 42532187
Ventricular tachycardia 87.74 12.01 182 79510 29978 42511665
Blood creatinine increased 84.39 12.01 418 79274 109585 42432058
Mitral valve incompetence 83.68 12.01 127 79565 16362 42525281
Respiratory tract haemorrhage 82.53 12.01 44 79648 1365 42540278
Anxiety 82.13 12.01 61 79631 118499 42423144
Wound 81.49 12.01 128 79564 16989 42524654
Chronic kidney disease 81.46 12.01 233 79459 47008 42494635
Treatment failure 80.15 12.01 11 79681 62613 42479030
Glomerular filtration rate abnormal 79.74 12.01 41 79651 1179 42540464
Completed suicide 77.28 12.01 42 79650 96423 42445220
Product use in unapproved indication 76.25 12.01 143 79549 184313 42357330
Product dose omission issue 74.67 12.01 108 79584 154257 42387386
Musculoskeletal pain 72.24 12.01 179 79513 33161 42508482
Pulmonary arterial hypertension 71.97 12.01 92 79600 10095 42531548
Weight increased 71.55 12.01 394 79298 107589 42434054
Neuropathy peripheral 69.77 12.01 53 79639 101800 42439843
Infusion related reaction 68.37 12.01 15 79677 60791 42480852
Urosepsis 68.31 12.01 110 79582 14910 42526733
Degenerative mitral valve disease 67.27 12.01 24 79668 269 42541374
Urinary hesitation 66.67 12.01 51 79641 2984 42538659
Ventricular hypokinesia 66.58 12.01 73 79619 6811 42534832
Cardiac aneurysm 66.17 12.01 35 79657 1068 42540575
Pleural effusion 66.03 12.01 357 79335 96809 42444834
Drug hypersensitivity 65.21 12.01 54 79638 99335 42442308
Aortic valve incompetence 64.31 12.01 70 79622 6478 42535165
Low cardiac output syndrome 64.05 12.01 29 79663 625 42541018
Paresis 63.93 12.01 46 79646 2450 42539193
Malaise 63.46 12.01 195 79497 211961 42329682
Cardiac failure acute 62.21 12.01 100 79592 13533 42528110
Tachypnoea 62.15 12.01 130 79562 21532 42520111
Arthralgia 61.84 12.01 188 79504 205050 42336593
Fracture 61.74 12.01 76 79616 8027 42533616
Rales 58.12 12.01 88 79604 11312 42530331
Therapeutic drug monitoring analysis incorrectly performed 57.57 12.01 22 79670 303 42541340
Intentional product misuse 57.27 12.01 22 79670 61878 42479765
Hyperuricaemia 57.17 12.01 79 79613 9345 42532298
Computerised tomogram coronary artery abnormal 56.84 12.01 18 79674 135 42541508
Disease progression 55.35 12.01 116 79576 143540 42398103
Foetal exposure during pregnancy 54.57 12.01 11 79681 47300 42494343
Fluid retention 54.54 12.01 156 79536 31463 42510180
Injection site pain 54.38 12.01 20 79672 57778 42483865
Therapeutic product effect incomplete 53.80 12.01 33 79659 70906 42470737
Hypervolaemia 53.12 12.01 127 79565 22998 42518645
Pulmonary congestion 53.05 12.01 101 79591 15629 42526014
Erysipelas 52.80 12.01 62 79630 6234 42535409
Brain natriuretic peptide increased 52.39 12.01 64 79628 6706 42534937
Gamma-glutamyltransferase increased 51.91 12.01 156 79536 32341 42509302
Left ventricular failure 51.59 12.01 60 79632 5971 42535672
Osteochondrosis 50.36 12.01 32 79660 1386 42540257
Gastrointestinal haemorrhage 50.32 12.01 334 79358 97392 42444251
Hypochromic anaemia 50.30 12.01 29 79663 1051 42540592
Asthma 50.09 12.01 27 79665 62287 42479356
Waist circumference increased 50.08 12.01 28 79664 956 42540687
Leriche syndrome 49.15 12.01 15 79677 98 42541545
Atrial enlargement 49.10 12.01 25 79667 704 42540939
Renal cyst 49.07 12.01 76 79616 9963 42531680
Left atrial enlargement 48.76 12.01 28 79664 1007 42540636
Stress 47.54 12.01 12 79680 44200 42497443
Diverticulum intestinal 47.35 12.01 53 79639 5060 42536583
Loss of personal independence in daily activities 47.27 12.01 17 79675 49799 42491844
Peripheral arterial occlusive disease 47.12 12.01 61 79631 6777 42534866
Febrile infection 46.94 12.01 40 79652 2731 42538912
Contraindicated product administered 46.85 12.01 128 79564 25144 42516499
Hepatic vein dilatation 45.87 12.01 17 79675 214 42541429
Rectal prolapse 45.74 12.01 22 79670 546 42541097
Deep vein thrombosis 45.49 12.01 46 79646 76911 42464732
Ejection fraction abnormal 45.43 12.01 29 79663 1266 42540377
Condition aggravated 45.11 12.01 711 78981 260043 42281600
Gastritis erosive 44.79 12.01 58 79634 6445 42535198
Micturition disorder 44.49 12.01 37 79655 2443 42539200
Concomitant disease aggravated 44.21 12.01 58 79634 6528 42535115
Circulatory collapse 44.10 12.01 120 79572 23516 42518127
Urticaria 44.05 12.01 44 79648 73992 42467651
Therapeutic response decreased 43.97 12.01 8 79684 37004 42504639
Dysuria 43.88 12.01 143 79549 30953 42510690
Musculoskeletal stiffness 43.62 12.01 27 79665 57738 42483905
Glycosylated haemoglobin increased 42.38 12.01 82 79610 12842 42528801
Joint swelling 42.13 12.01 39 79653 67983 42473660
Depression 41.98 12.01 91 79601 111272 42430371
Intentional overdose 41.78 12.01 22 79670 51434 42490209
Pulmonary vascular disorder 41.75 12.01 22 79670 666 42540977
Nicotine dependence 41.60 12.01 22 79670 671 42540972
Agitation 40.88 12.01 36 79656 64278 42477365
Helicobacter test positive 40.72 12.01 23 79669 801 42540842
Hyperparathyroidism secondary 40.57 12.01 31 79661 1811 42539832
Suicidal ideation 39.99 12.01 20 79672 48141 42493502
Infective exacerbation of chronic obstructive airways disease 39.98 12.01 32 79660 2001 42539642
Acute abdomen 39.92 12.01 32 79660 2005 42539638
Tricuspid valve incompetence 39.52 12.01 73 79619 11040 42530603
Headache 39.31 12.01 274 79418 239095 42302548
Coronary artery stenosis 39.23 12.01 70 79622 10309 42531334
Renal cyst haemorrhage 38.88 12.01 21 79671 669 42540974
Eye injury 38.82 12.01 24 79668 990 42540653
Tachyarrhythmia 38.55 12.01 42 79650 3890 42537753
Abdominal wall haemorrhage 38.52 12.01 19 79673 499 42541144
Hyperventilation 38.42 12.01 38 79654 3144 42538499
Liver palpable 38.28 12.01 16 79676 282 42541361
Bradyarrhythmia 38.10 12.01 35 79657 2640 42539003
Hypersensitivity 37.62 12.01 48 79644 72322 42469321
Blood potassium increased 37.51 12.01 97 79595 18439 42523204
C-reactive protein increased 36.89 12.01 224 79468 63336 42478307
Orthopnoea 36.82 12.01 48 79644 5369 42536274
Nasopharyngitis 36.56 12.01 63 79629 83933 42457710
Aortic dilatation 36.56 12.01 28 79664 1641 42540002
Hepatojugular reflux 36.41 12.01 20 79672 659 42540984
Skin ulcer 36.36 12.01 118 79574 25483 42516160
Drug intolerance 36.23 12.01 59 79633 80365 42461278
Intentional product use issue 35.95 12.01 49 79643 71784 42469859
Drug ineffective for unapproved indication 35.66 12.01 21 79671 46142 42495501
Nephrolithiasis 34.21 12.01 13 79679 36817 42504826
Product administration error 34.09 12.01 93 79599 18250 42523393
Lethargy 33.92 12.01 23 79669 46867 42494776
Haematuria 33.74 12.01 204 79488 57595 42484048
Hepatic cytolysis 33.67 12.01 5 79687 26839 42514804
Bone marrow failure 33.67 12.01 10 79682 33083 42508560
Migraine 33.63 12.01 4 79688 25410 42516233
SARS-CoV-2 antibody test positive 33.61 12.01 16 79676 388 42541255
Spleen ischaemia 33.49 12.01 10 79682 60 42541583
Ventricular extrasystoles 33.44 12.01 76 79616 13314 42528329
Pruritus 33.01 12.01 212 79480 188559 42353084
Normocytic anaemia 32.99 12.01 37 79655 3540 42538103
Congestive cardiomyopathy 32.98 12.01 59 79633 8705 42532938
Vena cava injury 32.89 12.01 15 79677 329 42541314
No adverse event 32.70 12.01 16 79676 39005 42502638
Platelet distribution width increased 32.53 12.01 12 79680 149 42541494
Renal failure 32.48 12.01 411 79281 143315 42398328
Cardiovascular insufficiency 32.25 12.01 27 79665 1799 42539844
Blood urea increased 32.11 12.01 134 79558 32659 42508984
Cardiac amyloidosis 32.05 12.01 28 79664 1977 42539666
Oedema 31.93 12.01 186 79506 51815 42489828
Lower respiratory tract infection 31.47 12.01 19 79673 41187 42500456
Therapeutic product effect decreased 31.40 12.01 17 79675 39133 42502510
Vascular anastomotic haemorrhage 31.03 12.01 14 79678 299 42541344
Polyuria 30.98 12.01 62 79630 9949 42531694
Jugular vein distension 30.88 12.01 18 79674 666 42540977
Hypotonia 30.81 12.01 60 79632 9439 42532204
Death 30.40 12.01 661 79031 470524 42071119
Periarthritis calcarea 30.38 12.01 10 79682 86 42541557
Cardio-respiratory arrest 30.36 12.01 39 79653 58597 42483046
Carotid arteriosclerosis 30.31 12.01 29 79663 2303 42539340
Ischaemic nephropathy 30.18 12.01 10 79682 88 42541555
Obstructive airways disorder 30.18 12.01 5 79687 24754 42516889
Haematemesis 30.04 12.01 124 79568 30075 42511568
Type V hyperlipidaemia 30.01 12.01 20 79672 940 42540703
Articular calcification 29.98 12.01 10 79682 90 42541553
Disorientation 29.82 12.01 141 79551 36248 42505395
Cough 29.75 12.01 483 79209 177620 42364023
Abdominal pain lower 29.50 12.01 68 79624 12024 42529619
Back pain 29.19 12.01 151 79541 141625 42400018
Delayed graft function 29.13 12.01 30 79662 2605 42539038
Urinary incontinence 29.10 12.01 98 79594 21570 42520073
Depressed level of consciousness 29.08 12.01 171 79521 47799 42493844
Abdominal discomfort 28.76 12.01 61 79631 75194 42466449
Prescribed underdose 28.67 12.01 61 79631 10221 42531422
Blood potassium abnormal 28.67 12.01 25 79667 1761 42539882
Blood loss anaemia 28.59 12.01 59 79633 9677 42531966
Disturbance in attention 28.43 12.01 121 79571 29745 42511898
Rhinorrhoea 28.26 12.01 12 79680 31782 42509861
Peripheral artery bypass 28.25 12.01 9 79683 69 42541574
Ulnar nerve injury 28.11 12.01 10 79682 111 42541532
Vascular compression 27.96 12.01 14 79678 380 42541263
Sedation 27.90 12.01 11 79681 30464 42511179
Red cell distribution width increased 27.65 12.01 48 79644 6916 42534727
Peripheral venous disease 27.31 12.01 31 79661 3005 42538638
Insomnia 27.22 12.01 121 79571 118132 42423511
Pulmonary embolism 27.17 12.01 123 79569 119489 42422154
Immobile 27.11 12.01 30 79662 2828 42538815
Therapy non-responder 27.10 12.01 36 79656 53323 42488320
Neuroleptic malignant syndrome 26.93 12.01 4 79688 21468 42520175
Abnormal behaviour 26.90 12.01 8 79684 26443 42515200
Intestinal haemorrhage 26.84 12.01 35 79657 3916 42537727
Blood pressure decreased 26.84 12.01 194 79498 58138 42483505
Left ventricular hypertrophy 26.81 12.01 56 79636 9263 42532380
Adrenal cyst 26.79 12.01 11 79681 185 42541458
Atrial flutter 26.78 12.01 82 79610 17169 42524474
Atrioventricular block complete 26.73 12.01 63 79629 11301 42530342
Hypertensive crisis 26.69 12.01 59 79633 10147 42531496
COVID-19 26.48 12.01 119 79573 115829 42425814
Palisaded neutrophilic granulomatous dermatitis 26.42 12.01 5 79687 0 42541643
Cardiac failure congestive 26.26 12.01 260 79432 85342 42456301
Colitis 26.21 12.01 29 79663 46543 42495100
Blood pressure systolic decreased 26.14 12.01 39 79653 4948 42536695
Acute respiratory distress syndrome 25.76 12.01 12 79680 30096 42511547
Atrial thrombosis 25.54 12.01 27 79665 2417 42539226
Product use issue 25.51 12.01 67 79625 76684 42464959
Procalcitonin increased 25.32 12.01 26 79666 2250 42539393
Type 2 diabetes mellitus 25.21 12.01 84 79608 18387 42523256
Sinusitis 24.95 12.01 31 79661 47261 42494382
Aortic valve sclerosis 24.92 12.01 19 79673 1106 42540537
Cytokine release syndrome 24.76 12.01 28 79664 44499 42497144
Low density lipoprotein abnormal 24.54 12.01 13 79679 398 42541245
Therapy partial responder 24.50 12.01 4 79688 20017 42521626
Psoriasis 24.47 12.01 33 79659 48571 42493072
Perineal cyst 24.34 12.01 11 79681 236 42541407
Arteriosclerotic gangrene 24.08 12.01 8 79684 71 42541572
Aortic arteriosclerosis 23.97 12.01 38 79654 5082 42536561
Drug reaction with eosinophilia and systemic symptoms 23.90 12.01 26 79666 42049 42499594
White blood cell count decreased 23.62 12.01 116 79576 110280 42431363
Haemoglobin decreased 23.52 12.01 363 79329 132108 42409535
Hepatitis E antibody positive 23.52 12.01 11 79681 256 42541387
Blood glucose abnormal 23.43 12.01 45 79647 7008 42534635
Appendicitis 23.34 12.01 5 79687 20608 42521035
Upper gastrointestinal haemorrhage 23.09 12.01 115 79577 30184 42511459
Heat stroke 22.99 12.01 18 79674 1090 42540553
Duodenitis 22.99 12.01 39 79653 5517 42536126
Psychotic disorder 22.96 12.01 13 79679 29195 42512448
Psoriatic arthropathy 22.88 12.01 9 79683 24958 42516685
Left ventricular enlargement 22.85 12.01 16 79676 816 42540827
Intraventricular haemorrhage 22.72 12.01 32 79660 3852 42537791
Spinal stenosis 22.68 12.01 42 79650 6364 42535279
Neurotoxicity 22.55 12.01 8 79684 23643 42518000
Influenza like illness 22.52 12.01 16 79676 31824 42509819
Intraductal papillary mucinous neoplasm 22.38 12.01 13 79679 478 42541165
Testicular swelling 22.34 12.01 23 79669 1996 42539647
Urogenital haemorrhage 22.25 12.01 15 79677 719 42540924
Renal function test abnormal 22.21 12.01 28 79664 3029 42538614
Hepatitis E virus test positive 22.02 12.01 11 79681 297 42541346
Thirst 21.98 12.01 51 79641 9057 42532586
Hyperglycaemia 21.95 12.01 154 79538 45705 42495938
Acute respiratory failure 21.94 12.01 136 79556 38722 42502921
Post-traumatic amnestic disorder 21.93 12.01 7 79685 54 42541589
Incorrect route of product administration 21.88 12.01 9 79683 24296 42517347
Cytomegalovirus infection 21.86 12.01 17 79675 32289 42509354
Akinesia 21.83 12.01 25 79667 2447 42539196
Small intestinal obstruction 21.81 12.01 3 79689 17058 42524585
Premature baby 21.79 12.01 8 79684 23145 42518498
Pleurothotonus 21.58 12.01 18 79674 1193 42540450
Anaphylactic reaction 21.54 12.01 29 79663 42714 42498929
Skin exfoliation 21.13 12.01 28 79664 41525 42500118
Bacterial infection 21.08 12.01 13 79679 27866 42513777
Drug withdrawal syndrome 21.05 12.01 7 79685 21542 42520101
Skin pressure mark 20.99 12.01 7 79685 63 42541580
Blood 25-hydroxycholecalciferol decreased 20.91 12.01 11 79681 332 42541311
Hepatic calcification 20.82 12.01 11 79681 335 42541308
Osteonecrosis of jaw 20.81 12.01 5 79687 19044 42522599
Gastrointestinal adenocarcinoma 20.79 12.01 7 79685 65 42541578
Arthritis 20.73 12.01 29 79663 42036 42499607
Prothrombin time prolonged 20.67 12.01 51 79641 9418 42532225
Fluid intake reduced 20.37 12.01 31 79661 4001 42537642
Immature granulocyte count increased 20.26 12.01 10 79682 263 42541380
Sleep disorder due to a general medical condition 20.24 12.01 4 79688 17449 42524194
Cardiovascular somatic symptom disorder 20.24 12.01 6 79686 35 42541608
Pneumocystis jirovecii pneumonia 20.10 12.01 11 79681 25170 42516473
Mitral valve thickening 20.02 12.01 12 79680 468 42541175
Chylothorax 20.00 12.01 17 79675 1157 42540486
Rectal haemorrhage 19.98 12.01 39 79653 49567 42492076
Coma 19.97 12.01 44 79648 53510 42488133
Nightmare 19.86 12.01 11 79681 25001 42516642
Internal haemorrhage 19.77 12.01 36 79656 5385 42536258
Activated partial thromboplastin time shortened 19.74 12.01 12 79680 480 42541163
Suicide attempt 19.67 12.01 35 79657 46065 42495578
Blood pressure increased 19.62 12.01 111 79581 101817 42439826
Cardiorenal syndrome 19.60 12.01 15 79677 878 42540765
Respiratory distress 19.47 12.01 30 79662 41790 42499853
Renal oncocytoma 19.46 12.01 9 79683 204 42541439
Inguinal hernia 19.45 12.01 48 79644 8864 42532779
Lymphopenia 19.39 12.01 8 79684 21555 42520088
Vision blurred 19.31 12.01 45 79647 53654 42487989
Anaphylactic shock 19.17 12.01 10 79682 23507 42518136
Rash erythematous 19.16 12.01 19 79673 32072 42509571
Neutrophil count decreased 19.12 12.01 58 79634 63357 42478286
Traumatic haemothorax 18.97 12.01 11 79681 403 42541240
Mental status changes 18.86 12.01 31 79661 42084 42499559
Hyperhidrosis 18.84 12.01 96 79596 90416 42451227
Interstitial lung disease 18.84 12.01 79 79613 78383 42463260
Peripheral artery occlusion 18.77 12.01 20 79672 1806 42539837
Blood glucose fluctuation 18.71 12.01 32 79660 4555 42537088
Hiatus hernia 18.57 12.01 46 79646 8514 42533129
Urine protein/creatinine ratio increased 18.54 12.01 14 79678 803 42540840
Extrapyramidal disorder 18.54 12.01 4 79688 16408 42525235
Gastrointestinal disorder 18.51 12.01 37 79655 46616 42495027
Hallucination 18.50 12.01 51 79641 57456 42484187
N-terminal prohormone brain natriuretic peptide abnormal 18.40 12.01 9 79683 232 42541411
Costal cartilage fracture 18.23 12.01 9 79683 237 42541406
Haemothorax 18.12 12.01 34 79658 5202 42536441
Drug interaction 18.08 12.01 639 79053 266360 42275283
Renal artery stenosis 18.08 12.01 22 79670 2295 42539348
Polyneuropathy 18.07 12.01 76 79616 18585 42523058
Prostate cancer 18.07 12.01 35 79657 44608 42497035
Left ventricular false tendon 17.99 12.01 6 79686 54 42541589
Respiratory arrest 17.95 12.01 16 79676 28408 42513235
Influenza 17.95 12.01 58 79634 62117 42479526
Seizure 17.84 12.01 142 79550 120419 42421224
Systolic dysfunction 17.79 12.01 25 79667 3003 42538640
Papillary renal cell carcinoma 17.76 12.01 10 79682 346 42541297
Bladder cancer 17.62 12.01 5 79687 17042 42524601
Paraesthesia 17.61 12.01 74 79618 73385 42468258
Stress urinary incontinence 17.60 12.01 7 79685 108 42541535
Anxiety disorder 17.58 12.01 20 79672 1943 42539700
Irritability 17.56 12.01 16 79676 28112 42513531
Diabetic foot 17.51 12.01 25 79667 3048 42538595
Mastication disorder 17.46 12.01 19 79673 1757 42539886
Colitis ulcerative 17.43 12.01 14 79678 26161 42515482
Lower gastrointestinal haemorrhage 17.36 12.01 52 79640 10756 42530887
Hepatic cirrhosis 17.36 12.01 78 79614 19624 42522019
Mucosal haemorrhage 17.34 12.01 19 79673 1771 42539872
Inferior vena cava syndrome 17.34 12.01 6 79686 61 42541582
Genitourinary tract infection 17.31 12.01 7 79685 113 42541530
Lung diffusion test abnormal 17.25 12.01 6 79686 62 42541581
Peripheral artery stenosis 17.25 12.01 14 79678 893 42540750
Heart rate decreased 17.20 12.01 26 79666 36506 42505137
Cardiac ventricular disorder 16.91 12.01 9 79683 278 42541365
Paranoia 16.72 12.01 3 79689 14023 42527620
Suspected transmission of an infectious agent via product 16.63 12.01 14 79678 940 42540703
Inappropriate schedule of product administration 16.59 12.01 108 79584 95794 42445849
Intentional self-injury 16.58 12.01 4 79688 15198 42526445
Adenocarcinoma of appendix 16.56 12.01 7 79685 127 42541516
Testicular seminoma (pure) 16.54 12.01 8 79684 201 42541442
Scrotal oedema 16.42 12.01 19 79673 1880 42539763
Intervertebral disc space narrowing 16.34 12.01 15 79677 1130 42540513
Adrenal adenoma 16.34 12.01 11 79681 526 42541117
Diabetic nephropathy 16.31 12.01 21 79671 2320 42539323
Eczema 16.30 12.01 24 79668 34062 42507581
Large intestine polyp 16.25 12.01 46 79646 9219 42532424
Spinal osteoarthritis 16.10 12.01 44 79648 8642 42533001
Diplopia 16.03 12.01 9 79683 20307 42521336
Hepatorenal syndrome 15.94 12.01 23 79669 2831 42538812
Bacteraemia 15.93 12.01 14 79678 25026 42516617
Cardiopulmonary exercise test abnormal 15.85 12.01 3 79689 0 42541643
Aspergillus infection 15.72 12.01 5 79687 15832 42525811
Rash macular 15.62 12.01 6 79686 16885 42524758
Congenital muscle absence 15.62 12.01 5 79687 39 42541604
Congenital vas deferens absence 15.62 12.01 5 79687 39 42541604
Sudden cardiac death 15.52 12.01 27 79665 3897 42537746
Hypovolaemia 15.47 12.01 52 79640 11433 42530210
Thoracic haemorrhage 15.46 12.01 8 79684 233 42541410
Pulmonary oedema 15.46 12.01 160 79532 53112 42488531
Arterial haemorrhage 15.44 12.01 15 79677 1214 42540429
Malignant neoplasm progression 15.43 12.01 129 79563 108271 42433372
Hepatic steatosis 15.36 12.01 80 79612 21368 42520275
Oliguria 15.14 12.01 45 79647 9268 42532375
Blood pressure systolic increased 15.10 12.01 18 79674 27950 42513693
Vertigo 15.09 12.01 113 79579 34234 42507409
Faecaloma 15.01 12.01 35 79657 6235 42535408
Oropharyngeal pain 14.98 12.01 36 79656 42474 42499169
Stenosis 14.88 12.01 19 79673 2082 42539561
Frequent bowel movements 14.82 12.01 11 79681 21396 42520247
Paraplegia 14.79 12.01 24 79668 3273 42538370
Bronchopulmonary aspergillosis 14.77 12.01 9 79683 19420 42522223
Micturition frequency decreased 14.74 12.01 9 79683 363 42541280
Pain 14.72 12.01 347 79345 244501 42297142
Serotonin syndrome 14.65 12.01 16 79676 25829 42515814
Bladder tamponade 14.63 12.01 11 79681 627 42541016
Protein deficiency 14.55 12.01 8 79684 264 42541379
Mitral valve calcification 14.55 12.01 11 79681 632 42541011
Left ventricular dysfunction 14.55 12.01 51 79641 11450 42530193
Medication error 14.52 12.01 109 79583 33045 42508598
Myasthenia gravis 14.49 12.01 6 79686 16131 42525512
Subarachnoid haematoma 14.42 12.01 8 79684 269 42541374
Blast cells present 14.40 12.01 10 79682 503 42541140
Hypertrophy 14.40 12.01 10 79682 503 42541140
Oral pain 14.37 12.01 3 79689 12593 42529050
Glomerular filtration rate increased 14.30 12.01 12 79680 802 42540841
Neoplasm progression 14.28 12.01 20 79672 28980 42512663
Mean cell volume increased 14.24 12.01 26 79666 3897 42537746
Occult blood 14.24 12.01 13 79679 973 42540670
Ocular hyperaemia 14.23 12.01 6 79686 15957 42525686
Pollakiuria 14.14 12.01 81 79611 22424 42519219
Iron deficiency anaemia 14.13 12.01 55 79637 12984 42528659
Cold sweat 14.13 12.01 50 79642 11280 42530363
Adverse event 14.11 12.01 14 79678 23626 42518017
Non-compaction cardiomyopathy 14.10 12.01 5 79687 55 42541588
Withdrawal syndrome 14.08 12.01 5 79687 14770 42526873
Albumin urine present 14.06 12.01 9 79683 395 42541248
Arthropathy 14.00 12.01 21 79671 29576 42512067
Cachexia 13.99 12.01 40 79652 8064 42533579
Right ventricular enlargement 13.96 12.01 10 79682 529 42541114
Injection site reaction 13.86 12.01 6 79686 15715 42525928
Sepsis 13.86 12.01 276 79416 199058 42342585
Encephalopathy 13.79 12.01 36 79656 41297 42500346
Subclavian artery occlusion 13.66 12.01 6 79686 120 42541523
Urogenital infection bacterial 13.63 12.01 5 79687 61 42541582
Actinic keratosis 13.62 12.01 30 79662 5146 42536497
Protein urine present 13.47 12.01 32 79660 5769 42535874
Adrenomegaly 13.47 12.01 9 79683 425 42541218
Accidental exposure to product 13.46 12.01 11 79681 20382 42521261
Sacroiliac joint dysfunction 13.44 12.01 6 79686 125 42541518
Lymphoma 13.39 12.01 5 79687 14316 42527327
Multiple sclerosis relapse 13.30 12.01 5 79687 14259 42527384
Benign gastrointestinal neoplasm 13.22 12.01 6 79686 130 42541513
Pulmonary mass 13.13 12.01 7 79685 16258 42525385
Tremor 13.06 12.01 117 79575 96812 42444831
Heart rate irregular 13.00 12.01 62 79630 15988 42525655
Blood creatinine abnormal 12.99 12.01 22 79670 3107 42538536
Sinus arrest 12.97 12.01 18 79674 2138 42539505
Blood sodium abnormal 12.93 12.01 10 79682 595 42541048
Unevaluable event 12.92 12.01 28 79664 34260 42507383
Drug resistance 12.88 12.01 28 79664 34220 42507423
Metamyelocyte count increased 12.85 12.01 9 79683 459 42541184
Mouth ulceration 12.74 12.01 6 79686 14957 42526686
Lumbar vertebral fracture 12.74 12.01 22 79670 3157 42538486
Injection site swelling 12.72 12.01 8 79684 16965 42524678
Prerenal failure 12.71 12.01 19 79673 2414 42539229
Hyperchromic anaemia 12.66 12.01 6 79686 144 42541499
Autoimmune colitis 12.63 12.01 13 79679 1128 42540515
Gallbladder hypofunction 12.57 12.01 3 79689 6 42541637
Overdose 12.52 12.01 131 79561 105133 42436510
Diabetic ketoacidosis 12.51 12.01 14 79678 22353 42519290
Spinal cord injury cauda equina 12.44 12.01 6 79686 150 42541493
Escherichia infection 12.43 12.01 3 79689 11393 42530250
Lipoprotein (a) increased 12.40 12.01 8 79684 356 42541287
Endotracheal intubation 12.39 12.01 24 79668 3761 42537882
Nodule 12.37 12.01 4 79688 12530 42529113
Polypectomy 12.35 12.01 10 79682 636 42541007
Hepatic enzyme increased 12.33 12.01 44 79648 45740 42495903
Neuralgia 12.32 12.01 18 79674 25629 42516014
Eye irritation 12.30 12.01 3 79689 11315 42530328
Product substitution issue 12.26 12.01 3 79689 11287 42530356
Hepatosplenomegaly 12.25 12.01 27 79665 4633 42537010
Pancytopenia 12.25 12.01 151 79541 117592 42424051
Rash pruritic 12.21 12.01 28 79664 33575 42508068
Myelosuppression 12.20 12.01 37 79655 40424 42501219
Cardioversion 12.17 12.01 12 79680 989 42540654
Intestinal obstruction 12.15 12.01 20 79672 27138 42514505
Fear of falling 12.08 12.01 8 79684 372 42541271
Mental impairment 12.03 12.01 4 79688 12313 42529330
Somatosensory evoked potentials abnormal 12.01 12.01 6 79686 162 42541481

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 3003.71 11.56 3233 143261 422062 110020743
Product prescribing error 1495.01 11.56 900 145594 50431 110392374
Cardiac failure 1414.34 11.56 1480 145014 186146 110256659
Product monitoring error 1340.00 11.56 488 146006 8439 110434366
Oedema peripheral 1151.17 11.56 1768 144726 326892 110115913
Haematochezia 1049.59 11.56 1009 145485 114515 110328290
Dyspnoea 950.84 11.56 3414 143080 1103458 109339347
Anaemia 838.78 11.56 2075 144419 545011 109897794
Drug ineffective 785.55 11.56 529 145965 1520011 108922794
Systemic infection 782.95 11.56 340 146154 9479 110433326
Renal impairment 762.76 11.56 1086 145408 187359 110255446
Acute kidney injury 679.10 11.56 2113 144381 633317 109809488
Atrial fibrillation 671.32 11.56 1139 145355 228503 110214302
Labelled drug-drug interaction medication error 577.00 11.56 402 146092 28900 110413905
Syncope 566.11 11.56 985 145509 201551 110241254
Dehydration 548.60 11.56 1170 145324 278341 110164464
Off label use 485.65 11.56 777 145717 1499408 108943397
Bradycardia 462.94 11.56 778 145716 154739 110288066
Electrolyte imbalance 455.63 11.56 384 146110 36644 110406161
Cardiac failure chronic 419.57 11.56 249 146245 13562 110429243
Fall 404.07 11.56 1725 144769 601757 109841048
Infusion related reaction 371.96 11.56 37 146457 381125 110061680
Joint swelling 358.25 11.56 75 146419 442770 110000035
Hyperkalaemia 352.87 11.56 640 145854 135156 110307649
Electrocardiogram abnormal 348.16 11.56 248 146246 18461 110424344
Hypotension 347.02 11.56 1493 145001 522356 109920449
Synovitis 346.14 11.56 3 146491 274089 110168716
Dyspnoea exertional 342.60 11.56 545 145949 103515 110339290
Therapeutic drug monitoring analysis not performed 329.07 11.56 116 146378 1815 110440990
Arrhythmia 326.39 11.56 431 146063 69144 110373661
Drug hypersensitivity 317.60 11.56 103 146391 453987 109988818
Treatment failure 301.53 11.56 16 146478 277218 110165587
Drug intolerance 299.13 11.56 84 146410 406428 110036377
Hypokalaemia 298.64 11.56 711 145783 181737 110261068
Arthropathy 296.58 11.56 22 146472 287500 110155305
Rash 294.11 11.56 395 146099 820569 109622236
Dizziness 290.01 11.56 1745 144749 696448 109746357
Systemic lupus erythematosus 288.64 11.56 11 146483 254327 110188478
Hypersensitivity 278.34 11.56 94 146400 403904 110038901
Melaena 274.45 11.56 394 146100 68363 110374442
Drug interaction 274.31 11.56 1349 145145 498834 109943971
Pallor 269.80 11.56 353 146141 56114 110386691
Glossodynia 269.00 11.56 5 146489 221999 110220806
Glomerular filtration rate decreased 268.47 11.56 256 146238 28700 110414105
Pulmonary arterial hypertension 248.52 11.56 259 146235 32309 110410496
Therapeutic product effect decreased 245.51 11.56 21 146473 244295 110198510
Lower respiratory tract infection 241.30 11.56 22 146472 243084 110199721
Blood creatinine increased 239.31 11.56 655 145839 182234 110260571
Haematoma 237.66 11.56 338 146156 58138 110384667
Hyponatraemia 224.23 11.56 716 145778 216937 110225868
Angina pectoris 224.15 11.56 340 146154 61955 110380850
Musculoskeletal stiffness 222.87 11.56 49 146445 279773 110163032
Alopecia 221.47 11.56 103 146391 364650 110078155
Pulmonary hypertension 218.28 11.56 315 146179 54905 110387900
Rheumatoid arthritis 212.86 11.56 66 146428 299547 110143258
Chronic kidney disease 208.90 11.56 368 146126 75923 110366882
Psoriatic arthropathy 203.02 11.56 15 146479 196746 110246059
Helicobacter infection 202.53 11.56 9 146485 181868 110260937
Folliculitis 198.28 11.56 5 146489 167648 110275157
N-terminal prohormone brain natriuretic peptide increased 198.13 11.56 115 146379 6006 110436799
Right ventricular failure 197.30 11.56 206 146288 25748 110417057
Arthralgia 196.22 11.56 467 146027 779165 109663640
Gastrointestinal haemorrhage 196.17 11.56 572 145922 164946 110277859
Urticaria 195.16 11.56 89 146405 318768 110124037
Haematemesis 195.06 11.56 310 146184 58798 110384007
Nasopharyngitis 194.62 11.56 143 146351 394218 110048587
Hypervolaemia 190.91 11.56 279 146215 49181 110393624
Mitral valve incompetence 188.95 11.56 227 146267 33102 110409703
Maternal exposure during pregnancy 186.77 11.56 53 146441 254830 110187975
Hepatic enzyme increased 183.65 11.56 98 146396 320794 110122011
Pericarditis 177.26 11.56 37 146457 219077 110223728
Irritable bowel syndrome 176.88 11.56 10 146484 164205 110278600
Fibromyalgia 176.41 11.56 13 146481 170896 110271909
Product administration error 175.19 11.56 231 146263 36986 110405819
Renal failure 174.32 11.56 677 145817 225897 110216908
Tachypnoea 170.92 11.56 235 146259 39160 110403645
Abdominal discomfort 169.54 11.56 163 146331 393695 110049110
Discomfort 168.13 11.56 39 146455 214668 110228137
Sinusitis 166.29 11.56 93 146401 296595 110146210
Pleural effusion 164.57 11.56 564 145930 177145 110265660
Swelling 163.42 11.56 135 146359 350906 110091899
Fluid retention 154.70 11.56 368 146126 93939 110348866
Exercise tolerance decreased 150.17 11.56 126 146368 11941 110430864
Malaise 147.90 11.56 430 146064 671389 109771416
Completed suicide 147.75 11.56 68 146426 242313 110200492
Cardiac failure acute 146.43 11.56 170 146324 23908 110418897
Intentional product use issue 145.84 11.56 73 146421 247833 110194972
Therapeutic product effect incomplete 145.68 11.56 57 146437 223748 110219057
Orthostatic intolerance 144.57 11.56 66 146428 2075 110440730
Stomatitis 143.97 11.56 90 146404 270152 110172653
Blood cholesterol increased 143.82 11.56 34 146460 184751 110258054
Diverticulum intestinal 140.98 11.56 120 146374 11599 110431206
Hyperglycaemia 140.61 11.56 333 146161 84757 110358048
C-reactive protein abnormal 139.36 11.56 8 146486 129687 110313118
Ventricular arrhythmia 135.28 11.56 110 146384 9977 110432828
Product use in unapproved indication 135.21 11.56 241 146253 447136 109995669
Tricuspid valve incompetence 132.71 11.56 161 146333 23712 110419093
Asthma 132.43 11.56 84 146410 250207 110192598
Pain 131.35 11.56 736 145758 954219 109488586
Product use issue 129.49 11.56 133 146361 311562 110131243
Anuria 128.60 11.56 160 146334 24181 110418624
Dysuria 128.23 11.56 261 146233 59970 110382835
Febrile neutropenia 127.31 11.56 139 146355 316628 110126177
Hypoaesthesia 127.26 11.56 137 146357 314086 110128719
Glomerular filtration rate abnormal 125.78 11.56 62 146432 2321 110440484
Disorientation 124.92 11.56 284 146210 70387 110372418
Gastrointestinal disorder 124.21 11.56 84 146410 241868 110200937
Urosepsis 124.16 11.56 177 146317 30498 110412307
Blood urea increased 124.01 11.56 244 146250 54713 110388092
Injury 122.39 11.56 41 146453 177224 110265581
Sleep disorder due to general medical condition, insomnia type 121.79 11.56 4 146490 105639 110337166
Ventricular tachycardia 121.38 11.56 229 146265 49780 110393025
Bursitis 120.58 11.56 15 146479 129903 110312902
Dyspnoea at rest 120.42 11.56 95 146399 8251 110434554
Inferior vena cava dilatation 120.02 11.56 46 146448 921 110441884
Migraine 119.74 11.56 39 146455 171613 110271192
Cardiac failure congestive 119.19 11.56 455 146039 150545 110292260
Joint range of motion decreased 118.28 11.56 12 146482 121820 110320985
Drug abuse 117.42 11.56 44 146450 177367 110265438
Tachyarrhythmia 116.98 11.56 93 146401 8168 110434637
Haemoglobin decreased 116.75 11.56 643 145851 248084 110194721
Injection site pain 116.30 11.56 45 146449 177877 110264928
Haematuria 116.26 11.56 305 146189 82700 110360105
Fracture 112.27 11.56 151 146343 24637 110418168
Circulatory collapse 110.77 11.56 202 146292 42791 110400014
Ventricular enlargement 110.19 11.56 40 146454 684 110442121
Hypotonia 109.12 11.56 119 146375 15626 110427179
Arterial haemorrhage 108.59 11.56 66 146428 3753 110439052
Arthritis 106.89 11.56 44 146450 167542 110275263
Exposure during pregnancy 106.72 11.56 44 146450 167380 110275425
Blister 105.08 11.56 88 146406 227288 110215517
Pruritus 102.86 11.56 409 146085 581151 109861654
Ill-defined disorder 101.97 11.56 40 146454 156813 110285992
Atrial flutter 101.16 11.56 142 146352 24120 110418685
Pancreatic steatosis 100.95 11.56 49 146445 1773 110441032
Blood loss anaemia 100.90 11.56 122 146372 17903 110424902
Gamma-glutamyltransferase increased 100.27 11.56 239 146255 61070 110381735
Therapeutic drug monitoring analysis incorrectly performed 99.72 11.56 37 146457 675 110442130
Sleep disorder 99.25 11.56 71 146423 198573 110244232
Paraesthesia 98.74 11.56 133 146361 276388 110166417
Anxiety 97.94 11.56 193 146301 344885 110097920
Ejection fraction decreased 97.73 11.56 186 146308 40694 110402111
Upper gastrointestinal haemorrhage 97.20 11.56 209 146285 49887 110392918
Respiratory tract haemorrhage 96.29 11.56 49 146445 1965 110440840
Lactic acidosis 95.18 11.56 305 146189 92506 110350299
Tachycardia 92.71 11.56 565 145929 226080 110216725
Waist circumference increased 92.51 11.56 46 146448 1755 110441050
Liver injury 91.94 11.56 42 146452 150371 110292434
Loss of personal independence in daily activities 91.53 11.56 42 146452 149978 110292827
Peripheral arterial occlusive disease 89.74 11.56 84 146410 9196 110433609
Toxicity to various agents 88.12 11.56 333 146161 480222 109962583
Grip strength decreased 85.96 11.56 5 146489 80169 110362636
Blood potassium increased 85.38 11.56 156 146338 33093 110409712
Urinary hesitation 82.66 11.56 60 146434 4598 110438207
Lymphatic fistula 82.21 11.56 40 146454 1455 110441350
Femoral hernia incarcerated 81.86 11.56 40 146454 1469 110441336
Dementia 80.56 11.56 148 146346 31525 110411280
Headache 79.70 11.56 766 145728 881611 109561194
Bradyarrhythmia 79.57 11.56 60 146434 4874 110437931
Pulmonary congestion 79.15 11.56 145 146349 30821 110411984
Faecaloma 78.76 11.56 98 146396 14810 110427995
Erysipelas 78.50 11.56 92 146402 13066 110429739
Brain natriuretic peptide increased 78.17 11.56 85 146409 11124 110431681
Mobility decreased 78.05 11.56 121 146373 237301 110205504
Peripheral circulatory failure 77.61 11.56 41 146453 1778 110441027
Ventricular hypokinesia 76.40 11.56 84 146410 11130 110431675
Injection site reaction 76.35 11.56 13 146481 89057 110353748
Acute respiratory failure 75.96 11.56 246 146248 75014 110367791
Hyperuricaemia 75.93 11.56 95 146399 14436 110428369
Lung disorder 75.68 11.56 76 146418 179971 110262834
Gait inability 74.57 11.56 44 146450 136332 110306473
Hiatus hernia 74.04 11.56 132 146362 27474 110415331
Road traffic accident 73.84 11.56 25 146469 107373 110335432
Osteoarthritis 73.48 11.56 80 146414 182543 110260262
Depression 73.47 11.56 198 146296 317137 110125668
Degenerative mitral valve disease 72.93 11.56 24 146470 301 110442504
Therapy non-responder 72.52 11.56 61 146433 157246 110285559
Orthopnoea 72.41 11.56 81 146413 10940 110431865
Hypoglycaemia 72.06 11.56 325 146169 115779 110327026
Left ventricular failure 71.92 11.56 82 146412 11307 110431498
Neutropenia 71.00 11.56 256 146238 374364 110068441
Cardiac aneurysm 70.70 11.56 38 146456 1707 110441098
Insomnia 70.62 11.56 243 146251 360347 110082458
Neuropathy peripheral 70.52 11.56 80 146414 179197 110263608
Glycosylated haemoglobin increased 69.96 11.56 118 146376 23501 110419304
Polyuria 69.80 11.56 101 146393 17637 110425168
Abdominal pain lower 69.43 11.56 153 146341 37130 110405675
Hyperparathyroidism secondary 68.95 11.56 47 146447 3257 110439548
Psoriasis 68.67 11.56 51 146443 139942 110302863
Wound infection 67.12 11.56 22 146472 96443 110346362
Concomitant disease aggravated 67.07 11.56 95 146399 16269 110426536
Aortic valve stenosis 66.30 11.56 60 146434 6290 110436515
Aortic arteriosclerosis 66.12 11.56 77 146417 10861 110431944
Therapeutic response decreased 65.42 11.56 23 146471 96476 110346329
Atrioventricular block complete 64.42 11.56 104 146390 19978 110422827
Aortic valve incompetence 64.22 11.56 76 146418 10905 110431900
Depressed level of consciousness 63.58 11.56 306 146188 111972 110330833
Disturbance in attention 62.89 11.56 203 146291 61792 110381013
Computerised tomogram coronary artery abnormal 62.85 11.56 18 146476 136 110442669
Inflammation 62.07 11.56 100 146394 193138 110249667
Helicobacter test positive 62.03 11.56 32 146462 1321 110441484
Joint stiffness 61.82 11.56 8 146486 67235 110375570
Cardiovascular disorder 61.26 11.56 109 146385 22651 110420154
Paresis 61.14 11.56 51 146443 4793 110438012
Cardiogenic shock 61.13 11.56 191 146303 57147 110385658
Epistaxis 61.09 11.56 337 146157 130035 110312770
Dry mouth 60.97 11.56 107 146387 199841 110242964
Drug ineffective for unapproved indication 60.87 11.56 30 146464 102808 110339997
Back pain 59.90 11.56 270 146224 370726 110072079
Coronary artery disease 59.84 11.56 220 146274 71470 110371335
Wound infection pseudomonas 59.30 11.56 38 146456 2373 110440432
Polyneuropathy 59.19 11.56 131 146363 31881 110410924
Low cardiac output syndrome 59.04 11.56 29 146465 1077 110441728
Prothrombin time prolonged 58.96 11.56 92 146402 17169 110425636
Thirst 58.48 11.56 104 146390 21603 110421202
Intentional product misuse 58.29 11.56 54 146440 132850 110309955
Wheezing 57.75 11.56 161 146333 255069 110187736
Internal haemorrhage 57.74 11.56 69 146425 10002 110432803
Anaphylactic reaction 56.89 11.56 41 146453 114259 110328546
Coronary artery stenosis 56.58 11.56 80 146414 13678 110429127
Hypochromic anaemia 56.27 11.56 41 146453 3160 110439645
Ascites 56.25 11.56 258 146236 92550 110350255
Gastritis erosive 55.72 11.56 74 146420 11926 110430879
Adverse event 55.51 11.56 38 146456 108771 110334034
Blood cholesterol decreased 55.18 11.56 38 146456 2678 110440127
Autoimmune disorder 55.16 11.56 10 146484 65473 110377332
Sciatica 54.62 11.56 27 146467 92372 110350433
Hepatic cytolysis 54.54 11.56 5 146489 55048 110387757
Duodenitis 54.36 11.56 64 146430 9132 110433673
Pulmonary fibrosis 54.28 11.56 34 146460 102008 110340797
Live birth 53.62 11.56 13 146481 69471 110373334
Leriche syndrome 53.60 11.56 16 146478 142 110442663
Incorrect route of product administration 53.50 11.56 10 146484 64051 110378754
Abdominal wall haemorrhage 53.33 11.56 24 146470 729 110442076
Restlessness 53.29 11.56 180 146314 56079 110386726
Medication error 53.19 11.56 278 146216 105088 110337717
Lower limb fracture 52.74 11.56 17 146477 75331 110367474
Pregnancy 52.35 11.56 4 146490 51063 110391742
Flatulence 52.21 11.56 170 146324 51979 110390826
Pulmonary oedema 51.79 11.56 267 146227 100392 110342413
Lower gastrointestinal haemorrhage 51.65 11.56 90 146404 18396 110424409
Eructation 50.94 11.56 77 146417 13980 110428825
Hepatic vein dilatation 50.69 11.56 17 146477 227 110442578
Nail disorder 50.67 11.56 8 146486 57927 110384878
Micturition disorder 50.26 11.56 45 146449 4653 110438152
Colitis ulcerative 49.83 11.56 20 146474 77343 110365462
Condition aggravated 49.59 11.56 1299 145195 733537 109709268
Red blood cell sedimentation rate increased 49.21 11.56 21 146473 78281 110364524
Knee arthroplasty 48.49 11.56 13 146481 64935 110377870
Stress 48.37 11.56 41 146453 105307 110337498
Pulmonary vascular disorder 48.15 11.56 25 146469 1046 110441759
Injection site erythema 47.90 11.56 33 146461 94143 110348662
Blood pressure decreased 47.71 11.56 288 146206 114803 110328002
Renal cyst 47.59 11.56 86 146408 18086 110424719
Atrioventricular block first degree 47.45 11.56 75 146419 14150 110428655
Night sweats 47.23 11.56 65 146429 133918 110308887
Neuroglycopenia 46.97 11.56 25 146469 1101 110441704
Left atrial enlargement 46.88 11.56 29 146465 1702 110441103
Product dose omission issue 46.81 11.56 243 146251 321539 110121266
Frequent bowel movements 46.73 11.56 18 146476 71372 110371433
Hypertensive crisis 46.49 11.56 101 146393 24271 110418534
Low density lipoprotein abnormal 46.46 11.56 20 146474 545 110442260
Atrial enlargement 46.45 11.56 25 146469 1126 110441679
Seroma 46.39 11.56 37 146457 3264 110439541
Febrile infection 46.39 11.56 42 146452 4406 110438399
Suicidal ideation 46.35 11.56 34 146460 93903 110348902
Adverse drug reaction 46.16 11.56 43 146451 105516 110337289
Hepatic cyst 45.73 11.56 54 146440 7729 110435076
Procalcitonin increased 45.68 11.56 40 146454 4016 110438789
Onychomadesis 45.64 11.56 4 146490 45659 110397146
Pericardial effusion 45.60 11.56 173 146321 57044 110385761
Urinary retention 45.45 11.56 198 146296 69485 110373320
Gastritis 44.99 11.56 165 146329 53534 110389271
Rhinorrhoea 44.68 11.56 42 146452 102624 110340181
Impaired healing 44.56 11.56 124 146370 196593 110246212
Renal cyst haemorrhage 43.78 11.56 21 146473 740 110442065
Diastolic dysfunction 43.61 11.56 67 146427 12337 110430468
Product quality issue 43.60 11.56 24 146470 77275 110365530
Ventricular extrasystoles 43.39 11.56 94 146400 22547 110420258
Atrial thrombosis 43.30 11.56 40 146454 4306 110438499
Left ventricular dysfunction 43.28 11.56 96 146398 23397 110419408
Coeliac disease 42.58 11.56 4 146490 43183 110399622
Infection 42.41 11.56 293 146201 361907 110080898
N-terminal prohormone brain natriuretic peptide abnormal 42.37 11.56 16 146478 307 110442498
Type 2 diabetes mellitus 42.20 11.56 109 146385 177123 110265682
Cardiorenal syndrome 41.74 11.56 28 146466 1890 110440915
Haemarthrosis 41.67 11.56 50 146444 7279 110435526
Hepatojugular reflux 41.42 11.56 20 146474 715 110442090
Osteochondrosis 41.42 11.56 31 146463 2490 110440315
Renal function test abnormal 41.28 11.56 55 146439 8891 110433914
Obstructive airways disorder 41.22 11.56 6 146488 46143 110396662
Product used for unknown indication 41.15 11.56 28 146466 1935 110440870
Infective exacerbation of chronic obstructive airways disease 41.13 11.56 34 146460 3156 110439649
Liver palpable 41.08 11.56 16 146478 335 110442470
Vena cava injury 41.04 11.56 16 146478 336 110442469
Hip arthroplasty 40.13 11.56 12 146482 55801 110387004
Inflammatory marker increased 39.85 11.56 70 146424 14399 110428406
Injection site swelling 39.75 11.56 16 146478 61774 110381031
Ear infection 39.14 11.56 17 146477 62715 110380090
Ear pain 39.08 11.56 11 146483 53215 110389590
Left ventricular hypertrophy 39.00 11.56 66 146428 13178 110429627
Muscle spasms 38.81 11.56 213 146281 277944 110164861
SARS-CoV-2 antibody test positive 38.49 11.56 16 146478 399 110442406
Amnesia 38.31 11.56 50 146444 105358 110337447
Intentional self-injury 38.17 11.56 3 146491 37426 110405379
Acute abdomen 37.56 11.56 33 146461 3328 110439477
Subdural haematoma 37.54 11.56 120 146374 36334 110406471
Contusion 37.54 11.56 170 146324 233191 110209614
Blood pressure systolic increased 37.24 11.56 33 146461 82958 110359847
Retrograde amnesia 37.20 11.56 19 146475 768 110442037
Cardioversion 36.91 11.56 28 146466 2295 110440510
Spleen ischaemia 36.90 11.56 10 146484 60 110442745
Spinal pain 36.78 11.56 78 146416 18437 110424368
Exostosis 36.65 11.56 8 146486 45948 110396857
Platelet distribution width increased 36.50 11.56 12 146482 150 110442655
Oropharyngeal pain 36.35 11.56 78 146416 135198 110307607
Dyspepsia 35.81 11.56 131 146363 190834 110251971
Vascular anastomotic haemorrhage 35.69 11.56 14 146480 299 110442506
Congestive cardiomyopathy 35.60 11.56 66 146428 14153 110428652
Intraventricular haemorrhage 35.37 11.56 40 146454 5467 110437338
Vascular resistance pulmonary decreased 35.33 11.56 10 146484 72 110442733
Nicotine dependence 35.29 11.56 22 146472 1309 110441496
Cardio-respiratory arrest 35.29 11.56 62 146432 115774 110327031
Haemoptysis 35.14 11.56 187 146307 71167 110371638
Dry eye 35.00 11.56 15 146479 55778 110387027
Ejection fraction abnormal 34.77 11.56 32 146462 3428 110439377
Sudden cardiac death 34.61 11.56 40 146454 5597 110437208
Hyperthyroidism 34.50 11.56 101 146393 29160 110413645
Taste disorder 34.48 11.56 22 146472 65365 110377440
Sleep disorder due to a general medical condition 34.34 11.56 13 146481 52099 110390706
Carotid arteriosclerosis 34.13 11.56 30 146464 3027 110439778
Hypertensive heart disease 34.07 11.56 36 146458 4560 110438245
Foot deformity 33.82 11.56 11 146483 48469 110394336
Jugular vein distension 33.75 11.56 23 146471 1593 110441212
Pain in extremity 33.57 11.56 449 146045 486669 109956136
Injection site bruising 33.43 11.56 13 146481 51250 110391555
Lethargy 33.38 11.56 45 146449 93531 110349274
Bundle branch block right 33.25 11.56 59 146435 12232 110430573
Periarthritis calcarea 33.18 11.56 10 146484 92 110442713
Rales 32.70 11.56 89 146405 24650 110418155
Mucosal haemorrhage 32.45 11.56 29 146465 2991 110439814
Ischaemic nephropathy 32.43 11.56 10 146484 100 110442705
Cardiovascular insufficiency 32.25 11.56 30 146464 3258 110439547
Leukopenia 32.23 11.56 320 146174 148471 110294334
Rash pruritic 32.19 11.56 50 146444 98019 110344786
Cachexia 32.11 11.56 60 146434 12945 110429860
Coagulation test abnormal 31.77 11.56 22 146472 1564 110441241
Coma 31.64 11.56 68 146426 117801 110325004
Gastroenteritis clostridial 31.60 11.56 19 146475 1059 110441746
Rectal haemorrhage 31.45 11.56 70 146424 119763 110323042
Stasis dermatitis 31.27 11.56 23 146471 1799 110441006
Aortic dilatation 31.19 11.56 25 146469 2221 110440584
Hypercholesterolaemia 31.09 11.56 45 146449 90792 110352013
Transfusion 31.07 11.56 89 146405 25383 110417422
Blood uric acid increased 31.05 11.56 80 146414 21449 110421356
Congenital coronary artery malformation 31.02 11.56 10 146484 117 110442688
Hyperventilation 31.00 11.56 48 146446 8899 110433906
Urogenital haemorrhage 30.90 11.56 18 146476 946 110441859
Renal artery stenosis 30.90 11.56 31 146463 3695 110439110
Type V hyperlipidaemia 30.73 11.56 21 146473 1461 110441344
Laryngitis 30.71 11.56 9 146485 42402 110400403
Testicular swelling 30.68 11.56 22 146472 1654 110441151
Immobile 30.52 11.56 44 146450 7658 110435147
Therapy partial responder 30.49 11.56 6 146488 37055 110405750
Peripheral venous disease 30.47 11.56 40 146454 84077 110358728
Aortic valve sclerosis 30.37 11.56 23 146471 1880 110440925
Disease risk factor 30.34 11.56 12 146482 262 110442543
Left-to-right cardiac shunt 30.20 11.56 11 146483 190 110442615
Influenza like illness 30.06 11.56 44 146450 88368 110354437
Contraindicated product administered 29.96 11.56 199 146295 248068 110194737
Left ventricular enlargement 29.89 11.56 17 146477 854 110441951
Respiratory failure 29.78 11.56 425 146069 214907 110227898
Serotonin syndrome 29.72 11.56 21 146473 59132 110383673
Gastrooesophageal reflux disease 29.61 11.56 130 146364 179846 110262959
Rash erythematous 29.55 11.56 39 146455 81793 110361012
Abdominal distension 29.38 11.56 358 146136 174745 110268060
Activated partial thromboplastin time shortened 29.37 11.56 18 146476 1039 110441766
Fear of falling 29.14 11.56 17 146477 896 110441909
No adverse event 28.97 11.56 33 146461 73806 110368999
Skin ulcer 28.79 11.56 163 146331 63482 110379323
COVID-19 28.79 11.56 198 146296 244862 110197943
Blood glucose increased 28.72 11.56 285 146209 132211 110310594
Paraesthesia oral 28.67 11.56 5 146489 33666 110409139
Influenza 28.52 11.56 121 146373 168980 110273825
Haemophagocytic lymphohistiocytosis 28.42 11.56 4 146490 31555 110411250
Neck pain 28.34 11.56 77 146417 123053 110319752
Onychomycosis 28.22 11.56 8 146486 38523 110404282
Burning sensation 28.18 11.56 30 146464 69182 110373623
Perineal cyst 28.12 11.56 11 146483 233 110442572
Upper respiratory tract infection 28.12 11.56 85 146409 131243 110311562
Tooth erosion 28.06 11.56 13 146481 423 110442382
Cardiac amyloidosis 28.05 11.56 26 146468 2811 110439994
Sinus node dysfunction 27.86 11.56 46 146448 9001 110433804
Multiple drug therapy 27.77 11.56 43 146451 7971 110434834
Jaundice 27.65 11.56 153 146341 59083 110383722
Cholestatic liver injury 27.58 11.56 41 146453 7335 110435470
Delayed graft function 27.47 11.56 31 146463 4226 110438579
Peripheral artery bypass 27.41 11.56 9 146485 112 110442693
Adrenal cyst 27.32 11.56 11 146483 252 110442553
Inappropriate schedule of product administration 27.28 11.56 158 146336 203479 110239326
Hepatitis E antibody positive 27.08 11.56 11 146483 258 110442547
Illness 26.87 11.56 42 146452 82129 110360676
Cough 26.84 11.56 801 145693 460840 109981965
Immunodeficiency 26.76 11.56 9 146485 38829 110403976
Ketoacidosis 26.75 11.56 48 146446 10039 110432766
Craniofacial fracture 26.73 11.56 16 146478 885 110441920
Arteriosclerotic gangrene 26.60 11.56 8 146486 73 110442732
Wound dehiscence 26.59 11.56 42 146452 7920 110434885
Pulmonary vein occlusion 26.38 11.56 9 146485 127 110442678
Multiple sclerosis relapse 26.36 11.56 17 146477 50223 110392582
Prerenal failure 26.30 11.56 31 146463 4428 110438377
International normalised ratio abnormal 26.19 11.56 37 146457 6320 110436485
Injection site pruritus 26.01 11.56 18 146476 51240 110391565
Arteriosclerosis 25.93 11.56 82 146412 24685 110418120
Coronavirus test positive 25.88 11.56 18 146476 1289 110441516
Hypovolaemia 25.73 11.56 75 146419 21599 110421206
Hepatitis E virus test positive 25.65 11.56 11 146483 297 110442508
Presyncope 25.37 11.56 130 146364 48757 110394048
Anal haemorrhage 25.28 11.56 32 146462 4920 110437885
Activated partial thromboplastin time prolonged 25.23 11.56 76 146418 22292 110420513
Blood glucose abnormal 25.18 11.56 54 146440 12862 110429943
Blood pressure increased 25.08 11.56 220 146274 258153 110184652
Intraductal papillary mucinous neoplasm 24.82 11.56 15 146479 844 110441961
Appendicitis 24.74 11.56 4 146490 28460 110414345
Polyserositis 24.70 11.56 16 146478 1018 110441787
Cerebral haemorrhage 24.68 11.56 159 146335 64809 110377996
Urinary tract infection 24.67 11.56 586 145908 325696 110117109
International normalised ratio increased 24.64 11.56 198 146296 86574 110356231
Post-traumatic amnestic disorder 24.43 11.56 7 146487 53 110442752
Rhonchi 24.35 11.56 30 146464 4488 110438317
Thrombin time prolonged 24.30 11.56 11 146483 339 110442466
Articular calcification 24.29 11.56 10 146484 243 110442562
Akinesia 24.17 11.56 27 146467 3640 110439165
Gastric polyps 24.03 11.56 33 146461 5490 110437315
Iron deficiency anaemia 23.98 11.56 94 146400 31465 110411340
Hepatorenal syndrome 23.93 11.56 30 146464 4567 110438238
Hepatic calcification 23.85 11.56 11 146483 354 110442451
Sprue-like enteropathy 23.81 11.56 19 146475 1677 110441128
Oral herpes 23.77 11.56 9 146485 36071 110406734
Parkinsonism 23.73 11.56 74 146420 22113 110420692
Craniocerebral injury 23.66 11.56 34 146460 5900 110436905
Drug tolerance decreased 23.64 11.56 4 146490 27536 110415269
Oral pain 23.59 11.56 10 146484 37434 110405371
Vascular compression 23.51 11.56 14 146480 767 110442038
Supraventricular extrasystoles 23.47 11.56 40 146454 8033 110434772
Blood creatine increased 23.42 11.56 49 146445 11472 110431333
Diabetic foot 23.38 11.56 28 146466 4067 110438738
Haemothorax 23.36 11.56 37 146457 6994 110435811
Labelled drug-drug interaction issue 23.35 11.56 28 146466 4073 110438732
Memory impairment 23.19 11.56 159 146335 196785 110246020
Wound 23.03 11.56 199 146295 234238 110208567
Urinary incontinence 23.02 11.56 126 146368 48461 110394344
Pneumothorax traumatic 23.01 11.56 10 146484 279 110442526
Ulnar nerve injury 22.78 11.56 10 146484 286 110442519
Throat tightness 22.66 11.56 8 146486 33481 110409324
Eczema 22.65 11.56 38 146456 72255 110370550
Rectal prolapse 22.51 11.56 22 146472 2541 110440264
Nephrogenic anaemia 22.45 11.56 29 146465 4548 110438257
Hypocalcaemia 22.44 11.56 156 146338 65210 110377595
Impaired quality of life 22.42 11.56 6 146488 30011 110412794
Gallbladder empyema 22.41 11.56 8 146486 130 110442675
Fracture blisters 22.35 11.56 7 146487 74 110442731
Poor venous access 22.34 11.56 3 146491 24519 110418286
Cardiomegaly 22.33 11.56 87 146407 29043 110413762
Prescribed overdose 22.30 11.56 52 146442 87529 110355276
Cardiovascular somatic symptom disorder 22.14 11.56 6 146488 36 110442769
Blindness transient 22.11 11.56 33 146461 5923 110436882
Peripheral artery occlusion 21.97 11.56 23 146471 2882 110439923
Psychotic disorder 21.97 11.56 21 146473 50916 110391889
Blood pressure fluctuation 21.94 11.56 41 146453 74783 110368022
Scrotal oedema 21.84 11.56 18 146476 1663 110441142
Cytomegalovirus infection 21.72 11.56 24 146470 54420 110388385
Gout 21.67 11.56 101 146393 36465 110406340
Bladder tamponade 21.65 11.56 13 146481 723 110442082
Heat stroke 21.62 11.56 19 146475 1916 110440889
Diverticulum intestinal haemorrhagic 21.54 11.56 29 146465 4734 110438071
Palpitations 21.51 11.56 313 146181 158899 110283906
Anaphylactic shock 21.37 11.56 22 146472 51524 110391281
Nocturia 21.34 11.56 60 146434 16930 110425875
Skin pressure mark 21.18 11.56 7 146487 89 110442716
Catheterisation cardiac 21.15 11.56 33 146461 6158 110436647
Lupus-like syndrome 21.13 11.56 14 146480 40778 110402027
Renal oncocytoma 21.12 11.56 9 146485 239 110442566
Blood 25-hydroxycholecalciferol decreased 21.08 11.56 11 146483 465 110442340
Disease progression 21.03 11.56 214 146280 243820 110198985
Musculoskeletal pain 20.99 11.56 350 146144 182673 110260132
Stenosis 20.94 11.56 24 146470 3327 110439478
Ischaemic stroke 20.90 11.56 109 146385 41154 110401651
Femoral artery dissection 20.87 11.56 6 146488 46 110442759
Asthenia 20.87 11.56 1114 145380 687885 109754920
Disability 20.83 11.56 7 146487 30216 110412589
Respiratory arrest 20.83 11.56 28 146466 58271 110384534
Fluid intake reduced 20.82 11.56 35 146459 6951 110435854
Actinic keratosis 20.72 11.56 35 146459 6978 110435827
Testicular seminoma (pure) 20.70 11.56 8 146486 164 110442641
Costal cartilage fracture 20.68 11.56 9 146485 252 110442553
Acute left ventricular failure 20.67 11.56 20 146474 2281 110440524
Left ventricular false tendon 20.65 11.56 6 146488 48 110442757
Nephrolithiasis 20.57 11.56 35 146459 66177 110376628
Cerebral infarction 20.39 11.56 128 146366 51710 110391095
Helplessness 20.34 11.56 10 146484 372 110442433
Impaired work ability 20.27 11.56 5 146489 26414 110416391
Neoplasm progression 20.20 11.56 34 146460 64561 110378244
Cardiopulmonary failure 20.18 11.56 37 146457 7866 110434939
Systolic dysfunction 20.15 11.56 27 146467 4388 110438417
Chronic gastritis 20.12 11.56 30 146464 5381 110437424
Right ventricular enlargement 20.07 11.56 14 146480 1007 110441798
Neuroleptic malignant syndrome 20.05 11.56 10 146484 34049 110408756
Diabetic nephropathy 20.05 11.56 24 146470 3484 110439321
Crush syndrome 20.03 11.56 10 146484 385 110442420
Colitis 19.97 11.56 69 146425 102254 110340551
Neurotoxicity 19.90 11.56 16 146478 42191 110400614
Throat irritation 19.87 11.56 25 146469 53527 110389278
Portal hypertensive gastropathy 19.87 11.56 18 146476 1890 110440915
Intentional overdose 19.85 11.56 99 146395 132402 110310403
Immature granulocyte count increased 19.83 11.56 13 146481 844 110441961
Drug withdrawal syndrome 19.80 11.56 13 146481 38041 110404764
Pelvic haematoma 19.73 11.56 14 146480 1035 110441770
Administration site discomfort 19.61 11.56 8 146486 190 110442615
Cerebral ischaemia 19.58 11.56 47 146447 12057 110430748
Blood creatinine abnormal 19.56 11.56 31 146463 5861 110436944
Chronic obstructive pulmonary disease 19.55 11.56 226 146268 108932 110333873
Hepatitis 19.48 11.56 58 146436 89996 110352809
Subgaleal haematoma 19.38 11.56 7 146487 118 110442687
Metabolic alkalosis 19.36 11.56 30 146464 5565 110437240
Pleurothotonus 19.29 11.56 20 146474 2478 110440327
Palisaded neutrophilic granulomatous dermatitis 19.21 11.56 5 146489 25 110442780
Pulmonary mass 19.06 11.56 13 146481 37288 110405517
Swelling face 18.88 11.56 61 146433 92260 110350545
Oliguria 18.83 11.56 61 146433 18596 110424209
Chronic sinusitis 18.76 11.56 5 146489 25079 110417726
Procedural pain 18.71 11.56 12 146482 35553 110407252
Hot flush 18.65 11.56 37 146457 65999 110376806
Traumatic haemothorax 18.57 11.56 12 146482 760 110442045
Folate deficiency 18.54 11.56 26 146468 4412 110438393
Cardiac disorder 18.47 11.56 168 146326 76112 110366693
Haemorrhagic erosive gastritis 18.43 11.56 12 146482 770 110442035
Intestinal haemorrhage 18.29 11.56 34 146460 7307 110435498
Osteonecrosis of jaw 18.26 11.56 22 146472 47995 110394810
White blood cell count decreased 18.22 11.56 205 146289 229185 110213620
Red blood cell sedimentation rate abnormal 18.12 11.56 5 146489 24504 110418301
Personality change 18.10 11.56 43 146451 10959 110431846
Basal ganglia haemorrhage 18.08 11.56 17 146477 1871 110440934
Irritability 18.08 11.56 22 146472 47787 110395018
Skin fissures 18.06 11.56 5 146489 24453 110418352
Nightmare 17.99 11.56 15 146479 38848 110403957
Spontaneous haemorrhage 17.97 11.56 14 146480 1194 110441611
Eye pain 17.96 11.56 24 146470 50075 110392730
Electrocardiogram QT prolonged 17.94 11.56 222 146272 108738 110334067
Accidental exposure to product 17.88 11.56 24 146470 49984 110392821
Hypertransaminasaemia 17.83 11.56 5 146489 24250 110418555
Stupor 17.80 11.56 36 146458 8229 110434576
Drug reaction with eosinophilia and systemic symptoms 17.67 11.56 53 146441 82042 110360763
Thirst decreased 17.66 11.56 9 146485 362 110442443
Glomerular filtration rate increased 17.65 11.56 17 146477 1928 110440877
Upper respiratory tract irritation 17.63 11.56 8 146486 248 110442557
Neuralgia 17.61 11.56 23 146471 48455 110394350
Blood potassium abnormal 17.53 11.56 24 146470 3981 110438824
Sinus rhythm 17.52 11.56 13 146481 1030 110441775
Chills 17.49 11.56 352 146142 190228 110252577
Tooth infection 17.45 11.56 4 146490 22212 110420593
Normocytic anaemia 17.44 11.56 31 146463 6436 110436369
Body temperature decreased 17.41 11.56 14 146480 36921 110405884
Mucosal erosion 17.27 11.56 20 146474 2804 110440001
Painful respiration 17.23 11.56 23 146471 3724 110439081
Chest wall haematoma 17.18 11.56 10 146484 525 110442280
Skin exfoliation 17.18 11.56 59 146435 87592 110355213
Biopsy skin abnormal 17.16 11.56 8 146486 264 110442541
Haemorrhoidal haemorrhage 17.13 11.56 35 146459 8058 110434747
Normal newborn 17.08 11.56 4 146490 21892 110420913
Myocardial infarction 17.04 11.56 353 146141 191730 110251075
Drug clearance decreased 17.00 11.56 24 146470 4098 110438707
Lymphadenopathy 16.99 11.56 37 146457 63798 110379007
Adverse reaction 16.96 11.56 9 146485 29585 110413220
Poor quality sleep 16.90 11.56 8 146486 28069 110414736
Food allergy 16.90 11.56 3 146491 19945 110422860
Injection site rash 16.90 11.56 5 146489 23414 110419391
Pulpitis dental 16.89 11.56 15 146479 1534 110441271
Dizziness postural 16.82 11.56 50 146444 14559 110428246
Macular degeneration 16.81 11.56 4 146490 21655 110421150
Cyanosis 16.79 11.56 81 146413 29660 110413145
Thoracic haemorrhage 16.78 11.56 8 146486 278 110442527
Small intestinal obstruction 16.76 11.56 11 146483 32202 110410603
Renal atrophy 16.73 11.56 18 146476 2328 110440477
Epilepsy 16.71 11.56 72 146422 100137 110342668
Shock haemorrhagic 16.69 11.56 76 146418 27171 110415634
Blood sodium decreased 16.59 11.56 97 146397 38222 110404583
Sneezing 16.54 11.56 11 146483 31973 110410832
Mental status changes 16.48 11.56 49 146445 76073 110366732
Muscle spasticity 16.45 11.56 14 146480 35901 110406904
Blood pressure systolic decreased 16.43 11.56 47 146447 13394 110429411
Femoral neck fracture 16.40 11.56 45 146449 12522 110430283
Neovascular age-related macular degeneration 16.32 11.56 10 146484 577 110442228
Nocturnal dyspnoea 16.29 11.56 16 146478 1859 110440946
Bone disorder 16.28 11.56 4 146490 21188 110421617
Eye disorder 16.26 11.56 9 146485 28897 110413908
Obesity 16.24 11.56 86 146408 113265 110329540
Injection site haemorrhage 16.23 11.56 12 146482 33016 110409789
Haematocrit decreased 16.20 11.56 146 146348 65971 110376834
Mitral valve thickening 16.19 11.56 11 146483 758 110442047
Feeling abnormal 16.18 11.56 157 146337 180554 110262251
Suspected transmission of an infectious agent via product 16.16 11.56 14 146480 1386 110441419
Genitourinary tract infection 16.12 11.56 8 146486 304 110442501
Groin pain 16.08 11.56 51 146443 15377 110427428
Spinal osteoarthritis 16.06 11.56 61 146433 20122 110422683
Photophobia 16.05 11.56 7 146487 25764 110417041
Ventricular assist device insertion 16.04 11.56 5 146489 52 110442753
Heart rate decreased 16.02 11.56 56 146438 82700 110360105
Subarachnoid haematoma 15.97 11.56 8 146486 310 110442495
Blood test abnormal 15.91 11.56 9 146485 28545 110414260
Crying 15.90 11.56 7 146487 25621 110417184
Inferior vena cava syndrome 15.85 11.56 6 146488 116 110442689
Liver function test increased 15.78 11.56 62 146432 88486 110354319
Escherichia infection 15.78 11.56 68 146426 23748 110419057
Vision blurred 15.77 11.56 103 146391 128919 110313886
Somatosensory evoked potentials abnormal 15.76 11.56 7 146487 206 110442599
Diabetic neuropathy 15.69 11.56 31 146463 6968 110435837
Genital erosion 15.66 11.56 11 146483 800 110442005
Micturition frequency decreased 15.63 11.56 12 146482 1001 110441804
Pelvi-ureteric obstruction 15.49 11.56 8 146486 331 110442474
Non-compaction cardiomyopathy 15.47 11.56 5 146489 59 110442746
Bradykinesia 15.46 11.56 40 146454 10748 110432057
Acne 15.44 11.56 13 146481 33507 110409298
Cytokine release syndrome 15.41 11.56 45 146449 70261 110372544
Initial insomnia 15.39 11.56 39 146455 10350 110432455
Adrenomegaly 15.30 11.56 9 146485 482 110442323
Swollen tongue 15.24 11.56 36 146458 60326 110382479
Pain in jaw 15.20 11.56 118 146376 51059 110391746
Paraparesis 15.13 11.56 24 146470 4542 110438263
Accidental overdose 15.11 11.56 119 146375 51715 110391090
Dry gangrene 15.11 11.56 12 146482 1052 110441753
Skin turgor decreased 15.08 11.56 11 146483 849 110441956
Apnoea 15.06 11.56 46 146448 13593 110429212
Sinus congestion 15.06 11.56 11 146483 30448 110412357
Benign gastrointestinal neoplasm 15.05 11.56 6 146488 134 110442671
Sinus arrest 15.03 11.56 23 146471 4219 110438586
Acute respiratory distress syndrome 14.86 11.56 30 146464 53168 110389637
Papillary renal cell carcinoma 14.85 11.56 8 146486 361 110442444
Constipation 14.80 11.56 597 145897 357189 110085616
Blood glucose fluctuation 14.80 11.56 32 146462 7666 110435139
Inguinal hernia 14.72 11.56 32 146462 7693 110435112
Right ventricular dysfunction 14.68 11.56 20 146474 3303 110439502
Nodule 14.61 11.56 13 146481 32618 110410187
Occult blood 14.59 11.56 15 146479 1841 110440964
Peripheral artery stenosis 14.54 11.56 13 146481 1341 110441464
Psychomotor retardation 14.53 11.56 32 146462 7760 110435045
Nephropathy 14.48 11.56 45 146449 13422 110429383
Spinal cord injury cauda equina 14.42 11.56 6 146488 150 110442655
Alanine aminotransferase decreased 14.37 11.56 15 146479 1873 110440932
Tuberculosis 14.37 11.56 3 146491 17771 110425034
Catheter site haemorrhage 14.36 11.56 27 146467 5853 110436952
Mental impairment 14.34 11.56 6 146488 22633 110420172
Intervertebral disc space narrowing 14.32 11.56 15 146479 1881 110440924
Catheter management 14.31 11.56 21 146473 3714 110439091
Hypertrophy 14.26 11.56 11 146483 924 110441881
Infusion site reaction 14.26 11.56 3 146491 17679 110425126
Glaucoma 14.21 11.56 6 146488 22511 110420294
Skin infection 14.20 11.56 6 146488 22503 110420302
Antidiuretic hormone abnormality 14.20 11.56 5 146489 78 110442727
Drug-disease interaction 14.06 11.56 15 146479 1921 110440884
Paranoia 14.06 11.56 6 146488 22368 110420437
Albumin urine present 14.05 11.56 10 146484 743 110442062
Macroangiopathy 13.99 11.56 6 146488 162 110442643
Hyperparathyroidism 13.99 11.56 21 146473 3789 110439016
Drug resistance 13.93 11.56 34 146460 56340 110386465
Ocular hyperaemia 13.90 11.56 19 146475 39267 110403538
Fungal infection 13.89 11.56 29 146465 50777 110392028
Varices oesophageal 13.88 11.56 30 146464 7185 110435620
Gastritis haemorrhagic 13.87 11.56 19 146475 3154 110439651
Subclavian artery occlusion 13.82 11.56 6 146488 167 110442638
Red cell distribution width abnormal 13.80 11.56 7 146487 279 110442526
Anticoagulation drug level increased 13.76 11.56 11 146483 974 110441831
Autoimmune colitis 13.75 11.56 15 146479 1970 110440835
Oral papilloma 13.75 11.56 5 146489 86 110442719
Injection site urticaria 13.72 11.56 3 146491 17212 110425593
Mastication disorder 13.71 11.56 20 146474 3518 110439287
Myoglobin blood increased 13.69 11.56 22 146472 4210 110438595
Sinoatrial block 13.67 11.56 13 146481 1452 110441353
Emotional distress 13.66 11.56 24 146470 44823 110397982
Neutrophil count decreased 13.57 11.56 99 146395 120842 110321963
Diet noncompliance 13.56 11.56 9 146485 597 110442208
Chronic coronary syndrome 13.55 11.56 7 146487 290 110442515
Sinus disorder 13.53 11.56 14 146480 32714 110410091
Humerus fracture 13.48 11.56 38 146456 10738 110432067
Bone marrow failure 13.44 11.56 36 146458 57812 110384993
Atrioventricular block 13.42 11.56 51 146443 16826 110425979
Affect lability 13.41 11.56 4 146490 18633 110424172
Uveitis 13.36 11.56 6 146488 21704 110421101
Transplant rejection 13.32 11.56 8 146486 24559 110418246
Drug level decreased 13.31 11.56 4 146490 18544 110424261
Bilirubin conjugated increased 13.28 11.56 27 146467 6197 110436608
Dysdiadochokinesis 13.24 11.56 8 146486 450 110442355
Hypogammaglobulinaemia 13.24 11.56 5 146489 20071 110422734
Iron deficiency 13.21 11.56 54 146440 18422 110424383
Dystonia 13.18 11.56 9 146485 25796 110417009
Cold sweat 13.16 11.56 61 146433 21970 110420835
Myasthenia gravis 13.15 11.56 6 146488 21505 110421300
Feeling hot 13.12 11.56 69 146425 91037 110351768
Eye irritation 13.07 11.56 15 146479 33437 110409368
Hypertensive emergency 13.07 11.56 19 146475 3332 110439473
Cardiac murmur functional 13.06 11.56 4 146490 39 110442766
Respiratory tract congestion 12.99 11.56 13 146481 30844 110411961
Mood swings 12.98 11.56 7 146487 22805 110420000
Cerebral ventricular rupture 12.97 11.56 8 146486 467 110442338
Cerebral arteriosclerosis 12.95 11.56 10 146484 842 110441963
Ischaemic cardiomyopathy 12.85 11.56 31 146463 7980 110434825
Petechiae 12.80 11.56 63 146431 23254 110419551
Congestive hepatopathy 12.78 11.56 24 146470 5196 110437609
Respiratory disorder 12.71 11.56 50 146444 71332 110371473
Cardiomyopathy 12.70 11.56 82 146412 33443 110409362
Diabetes mellitus inadequate control 12.65 11.56 75 146419 29700 110413105
Hepatic failure 12.61 11.56 143 146351 68596 110374209
Immune reconstitution inflammatory syndrome 12.59 11.56 3 146491 16223 110426582
Normochromic normocytic anaemia 12.56 11.56 42 146452 13015 110429790
Joint effusion 12.52 11.56 6 146488 20899 110421906
Blood sodium abnormal 12.48 11.56 12 146482 1358 110441447
Language disorder 12.48 11.56 20 146474 3818 110438987
Immunosuppression 12.44 11.56 4 146490 17755 110425050
Balanoposthitis 12.44 11.56 12 146482 1364 110441441
Hip fracture 12.44 11.56 17 146477 35134 110407671
Bone density decreased 12.38 11.56 3 146491 16039 110426766
Torsade de pointes 12.36 11.56 61 146433 22539 110420266
Endotracheal intubation 12.34 11.56 26 146468 6118 110436687
Withdrawal syndrome 12.34 11.56 14 146480 31366 110411439
Urogenital infection bacterial 12.32 11.56 5 146489 117 110442688
Hypothermia 12.32 11.56 68 146426 26234 110416571
Metamyelocyte count increased 12.31 11.56 9 146485 697 110442108
Chronic respiratory failure 12.23 11.56 20 146474 3883 110438922
Type 3 diabetes mellitus 12.20 11.56 5 146489 120 110442685
Gamma-glutamyltransferase abnormal 12.20 11.56 10 146484 917 110441888
Complications of transplanted kidney 12.15 11.56 29 146465 7413 110435392
Wrong product administered 12.13 11.56 37 146457 10923 110431882
Gastric mucosa erythema 12.11 11.56 8 146486 526 110442279
Middle insomnia 12.10 11.56 6 146488 20496 110422309
Sensorimotor disorder 12.09 11.56 11 146483 1161 110441644
Injection site warmth 12.05 11.56 4 146490 17401 110425404
Benign prostatic hyperplasia 12.03 11.56 52 146442 18182 110424623
Pneumocystis jirovecii pneumonia 12.02 11.56 24 146470 42711 110400094
Urine uric acid decreased 12.02 11.56 5 146489 125 110442680
Concomitant disease progression 12.00 11.56 19 146475 3591 110439214
Quadriparesis 11.97 11.56 22 146472 4685 110438120
Reactive gastropathy 11.92 11.56 9 146485 732 110442073
Haemophilus bacteraemia 11.92 11.56 6 146488 235 110442570
Insulin autoimmune syndrome 11.91 11.56 9 146485 733 110442072
Atheroembolism 11.91 11.56 7 146487 374 110442431
Cardiac pacemaker insertion 11.89 11.56 26 146468 6275 110436530
Oral candidiasis 11.86 11.56 26 146468 44734 110398071
Epstein-Barr virus infection 11.81 11.56 5 146489 18733 110424072
Dysphonia 11.79 11.56 56 146438 75873 110366932
Ventricular internal diameter abnormal 11.78 11.56 6 146488 241 110442564
Necrotising fasciitis 11.77 11.56 29 146465 7562 110435243
Pancreatitis 11.77 11.56 74 146420 93459 110349346
Blast cells present 11.73 11.56 10 146484 968 110441837
Potentiating drug interaction 11.69 11.56 38 146456 11605 110431200
Flank pain 11.65 11.56 61 146433 23069 110419736
Renal transplant failure 11.64 11.56 16 146478 2664 110440141
Generalised oedema 11.57 11.56 75 146419 30629 110412176

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03CA04 CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Sulfonamides, plain
ATC C03EB03 CARDIOVASCULAR SYSTEM
DIURETICS
DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
High-ceiling diuretics and potassium-sparing agents
FDA PE N0000175366 Increased Diuresis at Loop of Henle
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004232 Diuretics
MeSH PA D045283 Natriuretic Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D049994 Sodium Potassium Chloride Symporter Inhibitors
FDA EPC N0000175590 Loop Diuretic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:77608 loop diuretic

Related Drugs by ATC class:

C03CA Sulfonamides, plain 3 drugs
bumetanidefurosemidepiretanide
C03EB High-ceiling diuretics and potassium-sparing agents 2 drugs
bumetanidefurosemide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Decompensated cardiac failure indication 195111005
Edema indication 267038008
Pulmonary Edema due to Chronic Heart Failure indication
Peripheral Edema due to Chronic Heart Failure indication
Renal Disease with Edema indication
Edema due to Hepatic Cirrhosis indication
Metabolic alkalosis contraindication 1388004
Anuria contraindication 2472002 DOID:2983
Cirrhosis of liver contraindication 19943007 DOID:5082
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Gout contraindication 90560007 DOID:13189
Hearing disorder contraindication 128540005
Hypertriglyceridemia contraindication 302870006
Ascites contraindication 389026000
Azotemia contraindication 445009001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.25 acidic
pKa2 6.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Solute carrier family 12 member 1 Transporter INHIBITOR IC50 6.40 WOMBAT-PK CHEMBL

External reference:

IDSource
4020851 VUID
N0000148359 NUI
D00382 KEGG_DRUG
4020851 VANDF
C0076840 UMLSCUI
CHEBI:9637 CHEBI
CHEMBL1148 ChEMBL_ID
DB00214 DRUGBANK_ID
D000077786 MESH_DESCRIPTOR_UI
41781 PUBCHEM_CID
7312 IUPHAR_LIGAND_ID
3938 INN_ID
W31X2H97FB UNII
38413 RXNORM
43738 MMSL
5604 MMSL
d03189 MMSL
004414 NDDF
108476002 SNOMEDCT_US
318034005 SNOMEDCT_US
A1ATU PDB_CHEM_ID
W31X2H97FB INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-0077 TABLET 20 mg ORAL ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7997 TABLET 20 mg ORAL ANDA 23 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-8521 TABLET 10 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0904-7283 TABLET 20 mg ORAL ANDA 24 sections
Torsemide Human Prescription Drug Label 1 23155-871 TABLET 5 mg ORAL ANDA 25 sections
Torsemide Human Prescription Drug Label 1 23155-872 TABLET 10 mg ORAL ANDA 25 sections
Torsemide Human Prescription Drug Label 1 23155-873 TABLET 20 mg ORAL ANDA 25 sections
Torsemide Human Prescription Drug Label 1 23155-874 TABLET 100 mg ORAL ANDA 25 sections
Torsemide Human Prescription Drug Label 1 31722-529 TABLET 5 mg ORAL ANDA 24 sections
Torsemide Human Prescription Drug Label 1 31722-530 TABLET 10 mg ORAL ANDA 24 sections
Torsemide Human Prescription Drug Label 1 31722-531 TABLET 20 mg ORAL ANDA 24 sections
Torsemide Human Prescription Drug Label 1 31722-532 TABLET 100 mg ORAL ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-816 TABLET 5 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-817 TABLET 10 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-818 TABLET 20 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-819 TABLET 100 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 43353-315 TABLET 20 mg ORAL ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50090-6495 TABLET 100 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50090-6499 TABLET 20 mg ORAL ANDA 22 sections
Torsemide Human Prescription Drug Label 1 50090-7261 TABLET 20 mg ORAL ANDA 24 sections
Torsemide Human Prescription Drug Label 1 50090-7425 TABLET 100 mg ORAL ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50111-915 TABLET 5 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50111-916 TABLET 10 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50111-917 TABLET 20 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50111-918 TABLET 100 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50268-754 TABLET 5 mg ORAL ANDA 15 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50268-755 TABLET 10 mg ORAL ANDA 15 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50268-756 TABLET 20 mg ORAL ANDA 15 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50268-757 TABLET 100 mg ORAL ANDA 15 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 51407-362 TABLET 20 mg ORAL ANDA 24 sections