torsemide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diuretics, furosemide derivatives 2708 56211-40-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • torasemide
  • torsemide
  • toradiur
A pyridine and sulfonamide derivative that acts as a sodium-potassium chloride symporter inhibitor (loop diuretic). It is used for the treatment of EDEMA associated with CONGESTIVE HEART FAILURE; CHRONIC RENAL INSUFFICIENCY; and LIVER DISEASES. It is also used for the management of HYPERTENSION.
  • Molecular weight: 348.42
  • Formula: C16H20N4O3S
  • CLOGP: 3.21
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 100.19
  • ALOGS: -3.77
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
15 mg O
15 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.16 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 20 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 9.56 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 91 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.21 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.53 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 23, 1993 FDA MEDA PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 1306.22 11.45 1066 51872 114703 46518421
Product prescribing error 526.11 11.45 311 52627 19736 46613388
Cardiac failure 400.46 11.45 473 52465 79475 46553649
Drug ineffective 326.26 11.45 183 52755 677655 45955469
Product monitoring error 312.62 11.45 108 52830 1873 46631251
Haematochezia 304.15 11.45 287 52651 37206 46595918
Dyspnoea 221.98 11.45 1159 51779 514389 46118735
Oedema peripheral 190.88 11.45 501 52437 159205 46473919
Bradycardia 175.77 11.45 289 52649 66009 46567115
Acute kidney injury 174.19 11.45 625 52313 235230 46397894
Drug interaction 161.84 11.45 552 52386 202542 46430582
Dehydration 157.57 11.45 467 52471 159073 46474051
Anaemia 155.36 11.45 637 52301 255142 46377982
Rheumatoid arthritis 152.37 11.45 42 52896 240173 46392951
Syncope 145.24 11.45 348 52590 104455 46528669
Drug hypersensitivity 144.93 11.45 48 52890 243777 46389347
Arrhythmia 137.24 11.45 183 52755 34658 46598466
Atrial fibrillation 137.17 11.45 338 52600 103252 46529872
Pulmonary arterial hypertension 132.23 11.45 155 52783 25773 46607351
Fluid retention 131.88 11.45 220 52718 50826 46582298
Electrolyte imbalance 128.53 11.45 126 52812 17100 46616024
Rash 117.53 11.45 139 52799 356373 46276751
Haematemesis 116.06 11.45 153 52785 28653 46604471
Renal impairment 106.27 11.45 250 52688 74122 46559002
Orthostatic intolerance 105.01 11.45 42 52896 1112 46632012
Labelled drug-drug interaction medication error 104.93 11.45 85 52853 8976 46624148
Hypotension 101.52 11.45 526 52412 232063 46401061
Blood creatinine increased 100.77 11.45 249 52689 76154 46556970
Pallor 99.49 11.45 127 52811 23039 46610085
Fall 99.10 11.45 675 52263 328422 46304702
Completed suicide 93.40 11.45 25 52913 145895 46487229
Right ventricular failure 91.85 11.45 102 52836 15991 46617133
Fluid overload 90.91 11.45 132 52806 27053 46606071
Dyspnoea exertional 87.56 11.45 183 52755 50106 46583018
Joint swelling 86.55 11.45 40 52898 166033 46467091
Off label use 85.76 11.45 190 52748 379651 46253473
Treatment failure 85.40 11.45 5 52933 93082 46540042
Drug intolerance 78.85 11.45 34 52904 147015 46486109
Infusion related reaction 78.07 11.45 11 52927 101197 46531927
Hyperkalaemia 77.41 11.45 175 52763 50534 46582590
Pulmonary hypertension 77.21 11.45 143 52795 35850 46597274
Angina pectoris 75.36 11.45 120 52818 26655 46606469
Pain 75.17 11.45 283 52655 476665 46156459
Therapeutic drug monitoring analysis not performed 74.55 11.45 26 52912 464 46632660
Renal failure 73.60 11.45 289 52649 113305 46519819
Dizziness 73.31 11.45 646 52292 339768 46293356
Injection site pain 71.17 11.45 17 52921 107135 46525989
Gastrointestinal haemorrhage 71.07 11.45 221 52717 77152 46555972
Hypokalaemia 70.56 11.45 240 52698 87784 46545340
Glomerular filtration rate decreased 69.99 11.45 76 52862 11618 46621506
Oedema 67.65 11.45 198 52740 66873 46566251
Blood loss anaemia 64.58 11.45 63 52875 8494 46624630
Therapeutic product effect decreased 63.65 11.45 9 52929 82592 46550532
Arthropathy 63.49 11.45 10 52928 84690 46548434
Cardiac failure chronic 63.18 11.45 43 52895 3481 46629643
Anuria 61.05 11.45 70 52868 11361 46621763
Limb reduction defect 57.98 11.45 20 52918 345 46632779
Tachyarrhythmia 56.93 11.45 45 52893 4587 46628537
Melaena 56.65 11.45 108 52830 27664 46605460
Arthralgia 56.27 11.45 218 52720 364385 46268739
Aortic valve stenosis 55.72 11.45 38 52900 3086 46630038
Atrial flutter 55.70 11.45 60 52878 9088 46624036
Hypersensitivity 54.51 11.45 54 52884 150267 46482857
Product administration error 53.73 11.45 87 52851 19594 46613530
Sinusitis 52.59 11.45 42 52896 129726 46503398
Cardiogenic shock 51.09 11.45 77 52861 16307 46616817
Tricuspid valve incompetence 49.38 11.45 69 52869 13648 46619476
Depression 49.09 11.45 73 52865 170031 46463093
N-terminal prohormone brain natriuretic peptide increased 48.69 11.45 28 52910 1683 46631441
Lower respiratory tract infection 47.51 11.45 4 52934 55085 46578039
Hyponatraemia 47.47 11.45 234 52704 101098 46532026
Systemic lupus erythematosus 46.00 11.45 9 52929 65171 46567953
Arterial haemorrhage 45.94 11.45 27 52911 1691 46631433
Injection site erythema 45.29 11.45 14 52924 74413 46558711
Pancreatic steatosis 44.27 11.45 22 52916 983 46632141
Lymphatic fistula 43.58 11.45 21 52917 877 46632247
Femoral hernia incarcerated 43.33 11.45 21 52917 888 46632236
Mitral valve incompetence 43.08 11.45 77 52861 18775 46614349
Injection site reaction 42.60 11.45 3 52935 47846 46585278
Pleural effusion 42.06 11.45 196 52742 82756 46550368
Rhonchi 42.03 11.45 28 52910 2187 46630937
Alopecia 41.90 11.45 75 52863 162339 46470785
Musculoskeletal stiffness 41.90 11.45 30 52908 97963 46535161
Back pain 41.82 11.45 112 52826 209927 46423197
Anxiety 41.79 11.45 90 52848 181867 46451257
Cardiac failure congestive 40.94 11.45 209 52729 91541 46541583
Cardiac failure acute 40.68 11.45 48 52890 8030 46625094
Hyperthyroidism 39.34 11.45 57 52881 11654 46621470
Psoriasis 39.29 11.45 20 52918 78584 46554540
Exposure during pregnancy 39.07 11.45 39 52899 108173 46524951
Peripheral arterial occlusive disease 38.86 11.45 33 52905 3719 46629405
Chronic kidney disease 38.67 11.45 118 52820 40753 46592371
Malaise 37.61 11.45 221 52717 331011 46302113
Insomnia 37.51 11.45 82 52856 164842 46468282
Therapeutic product effect incomplete 37.43 11.45 21 52917 78132 46554992
Vascular resistance pulmonary decreased 37.12 11.45 10 52928 70 46633054
Limb hypoplasia congenital 36.90 11.45 12 52926 171 46632953
Left-to-right cardiac shunt 36.84 11.45 11 52927 116 46633008
Haemoglobin decreased 36.57 11.45 261 52677 128688 46504436
Cholestatic liver injury 36.28 11.45 25 52913 2065 46631059
Blood urea increased 35.93 11.45 85 52853 25267 46607857
Internal haemorrhage 35.89 11.45 34 52904 4421 46628703
Medication error 35.81 11.45 96 52842 30815 46602309
Diverticulum intestinal 35.69 11.45 39 52899 6002 46627122
Urticaria 35.57 11.45 49 52889 117843 46515281
Disorientation 35.32 11.45 107 52831 36811 46596313
Haematoma 34.94 11.45 97 52841 31775 46601349
Atrioventricular block complete 34.62 11.45 43 52895 7584 46625540
Left ventricular failure 34.45 11.45 35 52903 4955 46628169
Wound infection pseudomonas 34.07 11.45 21 52917 1434 46631690
Lactic acidosis 34.07 11.45 100 52838 33809 46599315
Product used for unknown indication 33.62 11.45 15 52923 524 46632600
Drug abuse 33.42 11.45 15 52923 63393 46569731
Haemarthrosis 32.39 11.45 27 52911 2966 46630158
Injection site swelling 32.00 11.45 4 52934 40323 46592801
Congenital oral malformation 31.98 11.45 11 52927 188 46632936
Cleft palate 31.54 11.45 17 52921 900 46632224
Seroma 31.48 11.45 23 52915 2084 46631040
Accidental overdose 31.44 11.45 70 52868 19996 46613128
Gamma-glutamyltransferase increased 31.31 11.45 93 52845 31647 46601477
Gastroenteritis clostridial 31.17 11.45 14 52924 497 46632627
Condition aggravated 30.74 11.45 418 52520 244634 46388490
Stasis dermatitis 30.70 11.45 15 52923 646 46632478
Toxicity to various agents 30.47 11.45 130 52808 211636 46421488
Coagulation test abnormal 30.36 11.45 15 52923 662 46632462
Hepatic cyst 30.33 11.45 32 52906 4734 46628390
Product use issue 29.91 11.45 38 52900 94606 46538518
Hypertensive emergency 29.62 11.45 20 52918 1598 46631526
Exercise tolerance decreased 29.60 11.45 31 52907 4546 46628578
Paraesthesia 29.59 11.45 55 52883 117382 46515742
Thirst 29.25 11.45 48 52890 10928 46622196
Bicytopenia 29.11 11.45 20 52918 1644 46631480
Transfusion 28.91 11.45 53 52885 13178 46619946
Anaphylactic reaction 28.89 11.45 12 52926 53100 46580024
Tooth erosion 28.82 11.45 13 52925 466 46632658
Aplastic anaemia 28.81 11.45 38 52900 7115 46626009
Neuropathy peripheral 28.20 11.45 37 52901 90856 46542268
Haemorrhagic erosive gastritis 28.02 11.45 11 52927 277 46632847
Discomfort 27.99 11.45 9 52929 46661 46586463
Ascites 27.76 11.45 98 52840 36486 46596638
Arthritis 27.75 11.45 28 52910 77288 46555836
Maternal exposure during pregnancy 27.67 11.45 46 52892 102503 46530621
Device stimulation issue 27.36 11.45 8 52930 78 46633046
Injection site pruritus 26.98 11.45 6 52932 39737 46593387
Eructation 26.71 11.45 37 52901 7258 46625866
Dysmorphism 26.66 11.45 20 52918 1887 46631237
Hypertensive crisis 26.60 11.45 52 52886 13563 46619561
Thrombin time prolonged 26.41 11.45 8 52930 89 46633035
N-terminal prohormone brain natriuretic peptide abnormal 26.36 11.45 7 52931 46 46633078
Sudden cardiac death 26.28 11.45 21 52917 2174 46630950
Headache 26.02 11.45 384 52554 477968 46155156
Painful respiration 25.64 11.45 22 52916 2515 46630609
Antineutrophil cytoplasmic antibody positive 25.62 11.45 12 52926 470 46632654
Administration site discomfort 25.49 11.45 8 52930 101 46633023
Pulpitis dental 25.27 11.45 14 52924 783 46632341
Respiratory failure 25.20 11.45 189 52749 94627 46538497
Erysipelas 25.12 11.45 35 52903 6903 46626221
Injection site bruising 24.97 11.45 5 52933 35631 46597493
Talipes 24.82 11.45 17 52921 1390 46631734
Psychomotor retardation 24.77 11.45 24 52914 3209 46629915
Escherichia infection 24.48 11.45 44 52894 10773 46622351
Nasopharyngitis 24.38 11.45 91 52847 153907 46479217
Febrile neutropenia 24.11 11.45 44 52894 94583 46538541
International normalised ratio increased 23.91 11.45 111 52827 46772 46586352
Biopsy skin abnormal 23.80 11.45 8 52930 127 46632997
Retrognathia 23.77 11.45 10 52928 302 46632822
Helplessness 23.48 11.45 9 52929 212 46632912
Migraine 23.30 11.45 27 52911 69999 46563125
Gout 22.95 11.45 44 52894 11312 46621812
Cardioversion 22.92 11.45 15 52923 1137 46631987
Circulatory collapse 22.90 11.45 65 52873 21559 46611565
Abdominal discomfort 22.85 11.45 91 52847 151074 46482050
Pulmonary congestion 22.48 11.45 51 52887 14748 46618376
Pneumothorax traumatic 22.47 11.45 8 52930 152 46632972
Feeling abnormal 22.44 11.45 70 52868 124990 46508134
Aortic arteriosclerosis 22.43 11.45 30 52908 5691 46627433
Hypoaesthesia 22.43 11.45 65 52873 118804 46514320
Hypoglycaemia 22.30 11.45 121 52817 54228 46578896
Faecaloma 22.16 11.45 35 52903 7717 46625407
Therapeutic drug monitoring analysis incorrectly performed 22.14 11.45 8 52930 159 46632965
Fracture 22.02 11.45 54 52884 16417 46616707
Inflammatory marker increased 21.91 11.45 29 52909 5446 46627678
Suicidal ideation 21.90 11.45 19 52919 56363 46576761
Systemic infection 21.53 11.45 12 52926 679 46632445
Pruritus 21.38 11.45 174 52764 242178 46390946
Loss of personal independence in daily activities 21.34 11.45 20 52918 57163 46575961
Asthma 21.22 11.45 45 52893 91497 46541627
Blood uric acid increased 21.21 11.45 25 52913 4176 46628948
Oropharyngeal pain 21.21 11.45 32 52906 74136 46558988
Polyneuropathy 20.98 11.45 43 52895 11601 46621523
Joint stiffness 20.77 11.45 3 52935 27105 46606019
Pelvic venous thrombosis 20.67 11.45 16 52922 1581 46631543
Chest wall haematoma 20.50 11.45 7 52931 117 46633007
Product use in unapproved indication 20.41 11.45 45 52893 90228 46542896
Bundle branch block right 20.03 11.45 26 52912 4793 46628331
Coma 19.96 11.45 22 52916 58327 46574797
No adverse event 19.83 11.45 7 52931 34224 46598900
Peripheral circulatory failure 19.74 11.45 9 52929 331 46632793
Spinal pain 19.59 11.45 38 52900 9854 46623270
Osteoarthritis 19.49 11.45 25 52913 62000 46571124
Lower gastrointestinal haemorrhage 19.49 11.45 32 52906 7288 46625836
Bradyarrhythmia 19.47 11.45 17 52921 1989 46631135
Glycosylated haemoglobin increased 19.41 11.45 40 52898 10836 46622288
Upper gastrointestinal haemorrhage 19.40 11.45 52 52886 16686 46616438
Tachycardia 19.27 11.45 185 52753 99437 46533687
Developmental hip dysplasia 19.16 11.45 14 52924 1269 46631855
Antidiuretic hormone abnormality 19.08 11.45 5 52933 31 46633093
Femoral artery dissection 19.08 11.45 5 52933 31 46633093
Pericardial effusion 19.01 11.45 68 52870 25475 46607649
Blood potassium increased 18.95 11.45 52 52886 16915 46616209
Acute respiratory failure 18.73 11.45 74 52864 29064 46604060
Catheterisation cardiac 18.67 11.45 23 52915 4024 46629100
Pregnancy 18.62 11.45 4 52934 27133 46605991
Psoriatic arthropathy 18.56 11.45 9 52929 36370 46596754
Post procedural haematuria 18.32 11.45 5 52933 37 46633087
Restlessness 18.20 11.45 67 52871 25457 46607667
Cerebral haemorrhage 18.19 11.45 72 52866 28299 46604825
Haemoptysis 18.05 11.45 68 52870 26121 46607003
Prothrombin time prolonged 17.96 11.45 36 52902 9560 46623564
Dry eye 17.92 11.45 6 52932 30316 46602808
Swelling 17.54 11.45 77 52861 124434 46508690
Dyspnoea at rest 17.54 11.45 21 52917 3567 46629557
Mobility decreased 17.46 11.45 26 52912 60568 46572556
Atrial septal defect 17.29 11.45 28 52910 6304 46626820
Pain in extremity 17.20 11.45 199 52739 258481 46374643
Sinoatrial block 17.13 11.45 11 52927 807 46632317
Urosepsis 17.10 11.45 47 52891 15306 46617818
Epistaxis 16.97 11.45 128 52810 64177 46568947
Intentional product use issue 16.87 11.45 21 52917 52759 46580365
White blood cell count decreased 16.68 11.45 68 52870 112163 46520961
Irritability 16.63 11.45 6 52932 28940 46604184
Wound dehiscence 16.53 11.45 23 52915 4531 46628593
Left ventricular dysfunction 16.32 11.45 36 52902 10219 46622905
Glomerular filtration rate abnormal 16.09 11.45 9 52929 513 46632611
Brain natriuretic peptide abnormal 16.05 11.45 8 52930 360 46632764
Cardio-respiratory arrest 16.01 11.45 27 52911 59842 46573282
Influenza 15.98 11.45 50 52888 89220 46543904
Toxoplasmosis 15.97 11.45 13 52925 1381 46631743
Herbal interaction 15.87 11.45 5 52933 64 46633060
Upper respiratory tract infection 15.79 11.45 30 52908 63526 46569598
Serotonin syndrome 15.76 11.45 4 52934 24216 46608908
Nephrolithiasis 15.65 11.45 9 52929 33042 46600082
Presyncope 15.63 11.45 62 52876 24392 46608732
Cerebral artery occlusion 15.60 11.45 11 52927 943 46632181
Multiple sclerosis relapse 15.40 11.45 15 52923 42110 46591014
Chronic respiratory failure 15.38 11.45 14 52924 1730 46631394
Waist circumference increased 15.27 11.45 10 52928 759 46632365
Ventricular assist device insertion 15.24 11.45 4 52934 25 46633099
Herpes zoster 15.20 11.45 34 52904 67838 46565286
Product quality issue 15.11 11.45 11 52927 35637 46597487
Depressed level of consciousness 15.08 11.45 99 52839 47470 46585654
Red cell distribution width abnormal 15.07 11.45 6 52932 157 46632967
Therapeutic response decreased 15.05 11.45 16 52922 43129 46589995
Renal function test abnormal 15.01 11.45 17 52921 2722 46630402
Gastrointestinal disorder 14.91 11.45 28 52910 59548 46573576
Adverse drug reaction 14.87 11.45 17 52921 44345 46588779
Periodontitis 14.83 11.45 19 52919 3457 46629667
Anal haemorrhage 14.77 11.45 13 52925 1538 46631586
Patent ductus arteriosus 14.76 11.45 20 52918 3842 46629282
Lethargy 14.70 11.45 22 52916 51149 46581975
Cerebral ischaemia 14.66 11.45 26 52912 6299 46626825
Influenza like illness 14.46 11.45 27 52911 57543 46575581
Coronary artery disease 14.42 11.45 76 52862 33676 46599448
Aggression 14.34 11.45 4 52934 22740 46610384
Hyperglycaemia 14.33 11.45 78 52860 34993 46598131
Stress 14.01 11.45 23 52915 51528 46581596
Neutropenia 13.94 11.45 100 52838 143104 46490020
Cardiac pacemaker insertion 13.90 11.45 19 52919 3680 46629444
Stomatitis 13.88 11.45 36 52902 68261 46564863
Blood cholesterol increased 13.78 11.45 15 52923 39998 46593126
Ear pain 13.72 11.45 4 52934 22088 46611036
Hypochromic anaemia 13.61 11.45 12 52926 1423 46631701
Cardiac murmur functional 13.59 11.45 4 52934 40 46633084
Injury 13.57 11.45 18 52920 44009 46589115
Catheter site haemorrhage 13.48 11.45 16 52922 2693 46630431
Contraindicated product administered 13.47 11.45 46 52892 79901 46553223
Musculoskeletal pain 13.44 11.45 130 52808 69998 46563126
Orthopnoea 13.41 11.45 24 52914 5856 46627268
Fibromyalgia 13.31 11.45 13 52925 36450 46596674
Cardiovascular disorder 13.26 11.45 37 52901 12150 46620974
Haematuria 13.26 11.45 63 52875 26795 46606329
Ecthyma 13.18 11.45 6 52932 220 46632904
Reactive gastropathy 13.16 11.45 7 52931 361 46632763
Abdominal distension 13.10 11.45 134 52804 73217 46559907
Pulmonary oedema 13.08 11.45 101 52837 51004 46582120
Concomitant disease aggravated 12.92 11.45 28 52910 7854 46625270
Alanine aminotransferase decreased 12.90 11.45 8 52930 552 46632572
Plasma cell myeloma 12.90 11.45 19 52919 44459 46588665
Febrile infection 12.86 11.45 11 52927 1252 46631872
Fungal infection 12.66 11.45 9 52929 29511 46603613
Periorbital haematoma 12.63 11.45 9 52929 784 46632340
Gastric perforation 12.57 11.45 11 52927 1291 46631833
Hypertensive heart disease 12.46 11.45 15 52923 2563 46630561
C-reactive protein increased 12.43 11.45 111 52827 58479 46574645
Swelling face 12.36 11.45 26 52912 53033 46580091
Throat tightness 12.34 11.45 4 52934 20635 46612489
Abdominal wall haemorrhage 12.34 11.45 5 52933 137 46632987
Polyuria 12.30 11.45 26 52912 7169 46625955
Milk-alkali syndrome 12.29 11.45 8 52930 601 46632523
Cardiovascular insufficiency 12.29 11.45 11 52927 1330 46631794
Necrotising fasciitis 12.25 11.45 15 52923 2608 46630516
Drug withdrawal syndrome 12.21 11.45 8 52930 27376 46605748
Vascular encephalopathy 12.20 11.45 7 52931 419 46632705
Generalised oedema 12.17 11.45 40 52898 14359 46618765
Neutrophil count decreased 12.16 11.45 19 52919 43407 46589717
Lymphadenopathy 12.16 11.45 12 52926 33476 46599648
Disturbance in attention 12.10 11.45 69 52869 31491 46601633
Diet noncompliance 12.06 11.45 6 52932 269 46632855
Right aortic arch 11.95 11.45 6 52932 274 46632850
Varicose vein ruptured 11.93 11.45 4 52934 63 46633061
Gamma-glutamyltransferase abnormal 11.91 11.45 6 52932 276 46632848
Drug dependence 11.65 11.45 4 52934 19897 46613227
Therapeutic response increased 11.52 11.45 6 52932 296 46632828

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 911.05 11.22 954 47293 98990 29805241
Cardiac failure 526.14 11.22 659 47588 82759 29821472
Oedema peripheral 291.38 11.22 571 47676 105261 29798970
Product prescribing error 290.50 11.22 230 48017 16503 29887728
Product monitoring error 228.54 11.22 91 48156 1650 29902581
Dyspnoea 224.17 11.22 1093 47154 332202 29572029
Haematochezia 213.00 11.22 269 47978 33953 29870278
Syncope 173.29 11.22 406 47841 84497 29819734
Drug ineffective 156.15 11.22 192 48055 340195 29564036
Cardiac failure chronic 140.81 11.22 98 48149 5765 29898466
Dizziness 116.14 11.22 619 47628 194290 29709941
Electrolyte imbalance 111.77 11.22 114 48133 11386 29892845
Toxicity to various agents 107.98 11.22 77 48170 177106 29727125
Acute kidney injury 106.92 11.22 780 47467 273062 29631169
Haematoma 100.67 11.22 156 48091 23797 29880434
Anaemia 99.99 11.22 624 47623 207368 29696863
Drug abuse 99.17 11.22 9 48238 82063 29822168
Pallor 98.29 11.22 144 48103 20905 29883326
Right ventricular failure 93.67 11.22 88 48159 7948 29896283
Bradycardia 92.27 11.22 273 47974 65253 29838978
Condition aggravated 86.20 11.22 444 47803 137422 29766809
Therapeutic drug monitoring analysis not performed 85.51 11.22 30 48217 375 29903856
Labelled drug-drug interaction medication error 78.83 11.22 91 48156 10447 29893784
Wound 74.74 11.22 96 48151 12306 29891925
Glomerular filtration rate decreased 73.31 11.22 91 48156 11271 29892960
Neutropenia 71.73 11.22 61 48186 128479 29775752
Melaena 71.43 11.22 160 48087 32277 29871954
Fall 69.01 11.22 515 47732 181357 29722874
Dyspnoea exertional 68.43 11.22 166 48081 35264 29868967
Completed suicide 67.73 11.22 38 48209 99454 29804777
Bradyarrhythmia 67.45 11.22 41 48206 1911 29902320
Hypokalaemia 63.97 11.22 202 48045 49990 29854241
Blood creatinine increased 63.22 11.22 303 47944 91072 29813159
Atrial fibrillation 61.22 11.22 339 47908 107785 29796446
Off label use 59.13 11.22 205 48042 249085 29655146
Drug interaction 57.42 11.22 531 47716 199037 29705194
Gastrointestinal haemorrhage 56.48 11.22 275 47972 83171 29821060
Arrhythmia 56.31 11.22 148 48099 33021 29871210
Angina pectoris 55.61 11.22 137 48110 29381 29874850
N-terminal prohormone brain natriuretic peptide increased 53.64 11.22 31 48216 1315 29902916
Hypotension 52.91 11.22 524 47723 200041 29704190
Fracture 52.03 11.22 56 48191 5950 29898281
Hepatojugular reflux 51.67 11.22 20 48227 335 29903896
Infusion related reaction 50.21 11.22 4 48243 40560 29863671
Hyperkalaemia 49.38 11.22 224 48023 65786 29838445
Pulmonary arterial hypertension 48.37 11.22 67 48180 9234 29894997
Left ventricular failure 47.62 11.22 49 48198 4942 29899289
Urinary hesitation 47.53 11.22 35 48212 2249 29901982
Pulmonary hypertension 46.58 11.22 98 48149 18938 29885293
Gamma-glutamyltransferase increased 45.84 11.22 127 48120 29223 29875008
Musculoskeletal pain 45.51 11.22 131 48116 30809 29873422
Dehydration 45.17 11.22 347 47900 123192 29781039
Anxiety 43.87 11.22 48 48199 89823 29814408
Contraindicated product administered 42.50 11.22 89 48158 17142 29887089
Febrile neutropenia 40.92 11.22 68 48179 106625 29797606
Tachyarrhythmia 40.51 11.22 36 48211 3025 29901206
Febrile infection 40.07 11.22 28 48219 1657 29902574
Fluid retention 38.87 11.22 108 48139 24890 29879341
Treatment failure 38.82 11.22 5 48242 34674 29869557
Renal impairment 37.45 11.22 248 47999 83936 29820295
Circulatory collapse 37.20 11.22 93 48154 20121 29884110
Rash 37.06 11.22 171 48076 191718 29712513
Malaise 36.42 11.22 142 48105 166820 29737411
Drug hypersensitivity 36.40 11.22 34 48213 68485 29835746
Hypochromic anaemia 36.04 11.22 20 48227 784 29903447
Neuropathy peripheral 35.10 11.22 37 48210 70438 29833793
Cardio-respiratory arrest 34.70 11.22 25 48222 57281 29846950
Fluid overload 34.26 11.22 87 48160 19005 29885226
Pleural effusion 34.04 11.22 220 48027 73846 29830385
Brain natriuretic peptide increased 33.86 11.22 37 48210 3998 29900233
Erysipelas 33.72 11.22 39 48208 4485 29899746
Agitation 33.52 11.22 23 48224 54050 29850181
Paresis 33.46 11.22 26 48221 1812 29902419
Prescribed underdose 33.23 11.22 51 48196 7708 29896523
Ventricular tachycardia 33.14 11.22 99 48148 23763 29880468
Thirst 33.09 11.22 48 48199 6901 29897330
Hyperuricaemia 32.23 11.22 49 48198 7345 29896886
Oedema 32.21 11.22 146 48101 42847 29861384
Weight increased 31.70 11.22 218 48029 74695 29829536
Concomitant disease aggravated 31.36 11.22 40 48207 5089 29899142
Low density lipoprotein abnormal 31.33 11.22 13 48234 263 29903968
Ascites 29.97 11.22 126 48121 35795 29868436
Heat stroke 29.36 11.22 18 48229 852 29903379
Dyspnoea at rest 29.34 11.22 28 48219 2578 29901653
Cardiac failure acute 29.34 11.22 53 48194 9156 29895075
Suicidal ideation 28.87 11.22 11 48236 36103 29868128
Headache 28.74 11.22 174 48073 182132 29722099
Ventricular arrhythmia 28.71 11.22 35 48212 4253 29899978
Intentional product misuse 28.66 11.22 10 48237 34657 29869574
Lethargy 28.48 11.22 14 48233 39505 29864726
Foetal exposure during pregnancy 28.22 11.22 12 48235 36859 29867372
Aortic valve incompetence 27.93 11.22 37 48210 4886 29899345
Respiratory tract haemorrhage 27.25 11.22 17 48230 830 29903401
Palisaded neutrophilic granulomatous dermatitis 27.16 11.22 5 48242 0 29904231
Blood loss anaemia 27.03 11.22 46 48201 7581 29896650
Osteochondrosis 26.99 11.22 16 48231 712 29903519
Disease progression 26.98 11.22 55 48192 79819 29824412
Depression 26.70 11.22 67 48180 90370 29813861
Pleurothotonus 26.69 11.22 18 48229 1005 29903226
Injection site pain 26.37 11.22 8 48239 30302 29873929
Product dose omission issue 26.20 11.22 69 48178 91562 29812669
Arthralgia 26.19 11.22 121 48126 135670 29768561
Haematemesis 25.95 11.22 97 48150 26106 29878125
Cardiac failure congestive 25.92 11.22 228 48019 84179 29820052
Asthma 25.79 11.22 13 48234 36161 29868070
Deep vein thrombosis 25.64 11.22 36 48211 60465 29843766
Insomnia 25.40 11.22 72 48175 93264 29810967
Arteriosclerotic gangrene 25.26 11.22 8 48239 71 29904160
Urticaria 24.66 11.22 31 48216 54575 29849656
Blood glucose abnormal 24.57 11.22 36 48211 5223 29899008
Atrial flutter 24.51 11.22 64 48183 14217 29890014
Bone marrow failure 23.93 11.22 9 48238 29776 29874455
Renal function test abnormal 23.87 11.22 24 48223 2355 29901876
Chronic kidney disease 23.65 11.22 122 48125 37716 29866515
Post-traumatic amnestic disorder 23.55 11.22 7 48240 49 29904182
Lower respiratory tract infection 23.33 11.22 7 48240 26707 29877524
Death 23.14 11.22 421 47826 356862 29547369
Musculoskeletal stiffness 22.58 11.22 15 48232 35866 29868365
Product prescribing issue 22.55 11.22 15 48232 818 29903413
Plasma cell myeloma 22.47 11.22 32 48215 53430 29850801
C-reactive protein increased 22.39 11.22 133 48114 43340 29860891
Paraesthesia 22.36 11.22 33 48214 54294 29849937
Abnormal behaviour 21.87 11.22 7 48240 25616 29878615
Psoriasis 21.51 11.22 22 48225 42484 29861747
Inferior vena cava dilatation 21.38 11.22 9 48238 189 29904042
Intestinal haemorrhage 21.23 11.22 26 48221 3175 29901056
Rheumatoid arthritis 21.22 11.22 21 48226 41176 29863055
Sudden cardiac death 20.98 11.22 28 48219 3724 29900507
Procalcitonin increased 20.75 11.22 16 48231 1102 29903129
Cardiovascular insufficiency 20.61 11.22 18 48229 1478 29902753
Thoracic haemorrhage 20.59 11.22 9 48238 208 29904023
Intentional overdose 20.40 11.22 22 48225 41459 29862772
Internal haemorrhage 20.27 11.22 30 48217 4392 29899839
Therapeutic response decreased 20.17 11.22 7 48240 24342 29879889
Osteonecrosis of jaw 20.09 11.22 3 48244 18615 29885616
Insulin autoimmune syndrome 19.79 11.22 9 48238 229 29904002
Peripheral artery stenosis 19.77 11.22 14 48233 846 29903385
Renal failure 19.58 11.22 304 47943 128662 29775569
Cardiovascular somatic symptom disorder 19.49 11.22 6 48241 48 29904183
Hepatorenal syndrome 19.31 11.22 22 48225 2489 29901742
Hypertensive crisis 19.26 11.22 42 48205 8315 29895916
Ejection fraction decreased 19.24 11.22 61 48186 15114 29889117
Intraventricular haemorrhage 19.11 11.22 24 48223 3006 29901225
Cardiorenal syndrome 18.82 11.22 13 48234 755 29903476
Gastritis erosive 18.77 11.22 33 48214 5580 29898651
Mitral valve incompetence 18.46 11.22 55 48192 13179 29891052
Cardiac aneurysm 18.38 11.22 12 48235 634 29903597
Loss of personal independence in daily activities 18.17 11.22 6 48241 21529 29882702
Akinesia 17.71 11.22 21 48226 2479 29901752
Hypersensitivity 17.56 11.22 38 48209 53990 29850241
Acute respiratory failure 17.32 11.22 85 48162 25765 29878466
White blood cell count decreased 17.26 11.22 73 48174 83874 29820357
Drug intolerance 17.22 11.22 29 48218 45262 29858969
Therapeutic product effect decreased 17.19 11.22 13 48234 29063 29875168
Sinusitis 17.17 11.22 17 48230 33328 29870903
Polyuria 17.16 11.22 37 48210 7269 29896962
Arthritis 17.05 11.22 9 48238 24392 29879839
Overdose 16.94 11.22 74 48173 84263 29819968
Orthopnoea 16.91 11.22 28 48219 4512 29899719
Low cardiac output syndrome 16.84 11.22 9 48238 327 29903904
Atrioventricular block complete 16.65 11.22 40 48207 8437 29895794
Back pain 16.63 11.22 97 48150 102499 29801732
Psychotic disorder 16.47 11.22 7 48240 21508 29882723
Congenital vas deferens absence 16.35 11.22 5 48242 39 29904192
Congenital muscle absence 16.35 11.22 5 48242 39 29904192
Neutrophil count decreased 16.31 11.22 27 48220 42427 29861804
Hypoglycaemia 16.31 11.22 139 48108 50842 29853389
Cranial sutures widening 16.29 11.22 6 48241 87 29904144
Dry gangrene 16.17 11.22 8 48239 247 29903984
Haemothorax 16.15 11.22 24 48223 3525 29900706
Respiratory arrest 16.15 11.22 14 48233 29244 29874987
Joint swelling 16.12 11.22 32 48215 46914 29857317
Drug withdrawal syndrome 15.89 11.22 6 48241 19803 29884428
Pyrexia 15.75 11.22 358 47889 294131 29610100
Polypectomy 15.71 11.22 10 48237 506 29903725
Anhidrosis 15.64 11.22 6 48241 98 29904133
Albumin urine present 15.59 11.22 9 48238 381 29903850
Blood glucose fluctuation 15.59 11.22 24 48223 3637 29900594
Rhinorrhoea 15.49 11.22 7 48240 20747 29883484
Vitamin B6 deficiency 15.43 11.22 7 48240 177 29904054
Dysdiadochokinesis 15.32 11.22 7 48240 180 29904051
Gallbladder hypofunction 15.32 11.22 4 48243 16 29904215
Genitourinary tract infection 15.31 11.22 6 48241 104 29904127
Scrotal oedema 14.90 11.22 15 48232 1474 29902757
Skin ulcer 14.85 11.22 65 48182 18784 29885447
Disorientation 14.83 11.22 94 48153 31324 29872907
Endotracheal intubation 14.81 11.22 19 48228 2431 29901800
Hanging 14.76 11.22 6 48241 115 29904116
Bladder tamponade 14.75 11.22 9 48238 422 29903809
Blood potassium abnormal 14.73 11.22 13 48234 1082 29903149
Neuroleptic malignant syndrome 14.73 11.22 4 48243 16291 29887940
Diverticulum intestinal 14.66 11.22 22 48225 3260 29900971
Product use in unapproved indication 14.59 11.22 65 48182 73628 29830603
Acute respiratory distress syndrome 14.52 11.22 10 48237 23462 29880769
Acute abdomen 14.44 11.22 16 48231 1755 29902476
Transfusion 14.44 11.22 35 48212 7426 29896805
Arterial haemorrhage 14.35 11.22 11 48236 751 29903480
Peripheral arterial occlusive disease 14.29 11.22 28 48219 5140 29899091
Eye contusion 14.00 11.22 9 48238 463 29903768
Potentiating drug interaction 13.93 11.22 26 48221 4605 29899626
Pericardial effusion 13.79 11.22 69 48178 21075 29883156
Benign gastrointestinal neoplasm 13.75 11.22 6 48241 138 29904093
Fear of falling 13.72 11.22 8 48239 345 29903886
Cerebral ventricular rupture 13.71 11.22 6 48241 139 29904092
Disturbance in attention 13.58 11.22 71 48176 22058 29882173
Nephrolithiasis 13.54 11.22 12 48235 24798 29879433
Seizure 13.47 11.22 98 48149 98377 29805854
Spinal cord injury cauda equina 13.44 11.22 6 48241 146 29904085
Blood pressure decreased 13.33 11.22 125 48122 46950 29857281
Somatosensory evoked potentials abnormal 13.29 11.22 6 48241 150 29904081
Influenza like illness 13.24 11.22 13 48234 25592 29878639
Interstitial lung disease 13.22 11.22 51 48196 60146 29844085
Iron deficiency anaemia 13.06 11.22 38 48209 8986 29895245
Small intestinal obstruction 13.03 11.22 3 48244 13656 29890575
Mental status changes 12.97 11.22 25 48222 37054 29867177
Pseudoporphyria 12.93 11.22 7 48240 261 29903970
Pain 12.90 11.22 198 48049 172443 29731788
Aortic valve sclerosis 12.61 11.22 11 48236 902 29903329
Skin haemorrhage 12.52 11.22 21 48226 3419 29900812
Costal cartilage fracture 12.49 11.22 5 48242 92 29904139
Unevaluable event 12.41 11.22 20 48227 31765 29872466
Colitis 12.41 11.22 19 48228 30801 29873430
Intentional product use issue 12.37 11.22 25 48222 36415 29867816
Lymphopenia 12.34 11.22 3 48244 13160 29891071
Tremor 12.34 11.22 71 48176 75292 29828939
Psoriatic arthropathy 12.27 11.22 5 48242 15756 29888475
Nasopharyngitis 12.20 11.22 51 48196 58798 29845433
Hyposmia 12.19 11.22 6 48241 183 29904048
Red blood cells urine positive 12.15 11.22 14 48233 1603 29902628
Renal cyst 12.10 11.22 34 48213 7883 29896348
Cardiac amyloidosis 12.09 11.22 10 48237 762 29903469
Stress urinary incontinence 12.06 11.22 5 48242 101 29904130
Stress 12.02 11.22 9 48238 20226 29884005
Migraine 11.94 11.22 3 48244 12871 29891360
Blood urea increased 11.91 11.22 89 48158 31292 29872939
Cardiopulmonary failure 11.81 11.22 22 48225 3889 29900342
Haemoglobin decreased 11.70 11.22 253 47994 113845 29790386
Therapeutic product effect incomplete 11.67 11.22 23 48224 33811 29870420
Product administration error 11.65 11.22 50 48197 14327 29889904
Product quality issue 11.61 11.22 8 48239 18766 29885465
Normochromic normocytic anaemia 11.58 11.22 22 48225 3948 29900283
Urogenital infection bacterial 11.55 11.22 4 48243 48 29904183
Chylothorax 11.53 11.22 9 48238 631 29903600
Prothrombin time prolonged 11.43 11.22 37 48210 9266 29894965
Dyskinesia 11.39 11.22 11 48236 21823 29882408
Quadriparesis 11.37 11.22 11 48236 1030 29903201
Abnormal palmar/plantar creases 11.28 11.22 6 48241 216 29904015
Urine uric acid decreased 11.26 11.22 5 48242 120 29904111

Pharmacologic Action:

SourceCodeDescription
ATC C03CA04 CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Sulfonamides, plain
FDA PE N0000175366 Increased Diuresis at Loop of Henle
FDA EPC N0000175590 Loop Diuretic
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004232 Diuretics
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D045283 Natriuretic Agents
MeSH PA D049994 Sodium Potassium Chloride Symporter Inhibitors
CHEBI has role CHEBI:35674 antihypertensive
CHEBI has role CHEBI:77608 loop diuretics

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Decompensated cardiac failure indication 195111005
Edema indication 267038008
Pulmonary Edema due to Chronic Heart Failure indication
Peripheral Edema due to Chronic Heart Failure indication
Renal Disease with Edema indication
Edema due to Hepatic Cirrhosis indication
Metabolic alkalosis contraindication 1388004
Anuria contraindication 2472002 DOID:2983
Cirrhosis of liver contraindication 19943007 DOID:5082
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Gout contraindication 90560007 DOID:13189
Hearing disorder contraindication 128540005
Hypertriglyceridemia contraindication 302870006
Ascites contraindication 389026000
Azotemia contraindication 445009001

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.25 acidic
pKa2 6.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Solute carrier family 12 member 1 Transporter INHIBITOR IC50 6.40 WOMBAT-PK CHEMBL

External reference:

IDSource
4020851 VUID
N0000148359 NUI
D00382 KEGG_DRUG
4020851 VANDF
C0076840 UMLSCUI
CHEBI:9637 CHEBI
CHEMBL1148 ChEMBL_ID
D000077786 MESH_DESCRIPTOR_UI
3938 INN_ID
DB00214 DRUGBANK_ID
W31X2H97FB UNII
41781 PUBCHEM_CID
7312 IUPHAR_LIGAND_ID
38413 RXNORM
43738 MMSL
5604 MMSL
d03189 MMSL
004414 NDDF
108476002 SNOMEDCT_US
318034005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-0077 TABLET 20 mg ORAL ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0517-0770 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0517-0771 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-5575 TABLET 20 mg ORAL ANDA 23 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7997 TABLET 20 mg ORAL ANDA 23 sections
Torsemide Human Prescription Drug Label 1 31722-529 TABLET 5 mg ORAL ANDA 24 sections
Torsemide Human Prescription Drug Label 1 31722-530 TABLET 10 mg ORAL ANDA 24 sections
Torsemide Human Prescription Drug Label 1 31722-531 TABLET 20 mg ORAL ANDA 24 sections
Torsemide Human Prescription Drug Label 1 31722-532 TABLET 100 mg ORAL ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-816 TABLET 5 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-817 TABLET 10 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-818 TABLET 20 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-819 TABLET 100 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 43353-315 TABLET 20 mg ORAL ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50111-915 TABLET 5 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50111-916 TABLET 10 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50111-917 TABLET 20 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50111-918 TABLET 100 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50268-754 TABLET 5 mg ORAL ANDA 18 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50268-755 TABLET 10 mg ORAL ANDA 18 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50268-756 TABLET 20 mg ORAL ANDA 18 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50268-757 TABLET 100 mg ORAL ANDA 18 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 51407-362 TABLET 20 mg ORAL ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 54868-1234 TABLET 100 mg ORAL ANDA 11 sections
Demadex HUMAN PRESCRIPTION DRUG LABEL 1 54868-3835 TABLET 10 mg ORAL NDA 12 sections
Demadex HUMAN PRESCRIPTION DRUG LABEL 1 54868-4687 TABLET 20 mg ORAL NDA 12 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 54868-5180 TABLET 20 mg ORAL ANDA 11 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 54868-6048 TABLET 10 mg ORAL ANDA 11 sections
Torsemide Human Prescription Drug Label 1 57237-138 TABLET 5 mg ORAL ANDA 25 sections
Torsemide Human Prescription Drug Label 1 57237-139 TABLET 10 mg ORAL ANDA 25 sections