bumetanide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diuretics, piretanide derivatives	427	28395-03-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: bumetanide bumethanide bufenox	A sulfamyl diuretic. Molecular weight: 364.42 Formula: C17H20N2O5S CLOGP: 3.07 LIPINSKI: 0 HAC: 7 HDO: 3 TPSA: 118.72 ALOGS: -4.15 ROTB: 8 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

bumetanide
bumethanide
bufenox

A sulfamyl diuretic.

Molecular weight: 364.42
Formula: C17H20N2O5S
CLOGP: 3.07
LIPINSKI: 0
HAC: 7
HDO: 3
TPSA: 118.72
ALOGS: -4.15
ROTB: 8

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
1	mg	O
1	mg	P
1	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.10 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	45 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.46 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	90 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.16 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	2.50 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.03 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	1.20 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Feb. 28, 1983	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	247.13	13.45	429	27771	262986	63197836
Cardiac failure congestive	238.04	13.45	247	27953	92186	63368636
Hypervolaemia	200.21	13.45	136	28064	28277	63432545
Fluid retention	199.43	13.45	184	28016	59502	63401320
Dyspnoea	180.44	13.45	672	27528	660641	62800181
Pulmonary arterial hypertension	137.85	13.45	99	28101	22478	63438344
Right ventricular failure	134.88	13.45	88	28112	17100	63443722
Body tinea	131.19	13.45	44	28156	1841	63458981
Pulmonary hypertension	125.02	13.45	115	28085	37008	63423814
Inhibitory drug interaction	109.91	13.45	43	28157	2806	63458016
Renal failure	109.15	13.45	191	28009	117461	63343361
Infection susceptibility increased	104.42	13.45	44	28156	3477	63457345
Drug ineffective	103.94	13.45	192	28008	1044573	62416249
Cardiac failure	99.12	13.45	157	28043	88985	63371837
Oedema peripheral	91.89	13.45	236	27964	189275	63271547
Maternal exposure during pregnancy	84.45	13.45	3	28197	220059	63240763
Rheumatoid arthritis	83.77	13.45	8	28192	253811	63207011
Purpura	83.76	13.45	56	28144	11329	63449493
Glucose tolerance impaired	83.76	13.45	46	28154	6531	63454291
International normalised ratio increased	83.41	13.45	103	28097	46322	63414500
Renal impairment	78.76	13.45	141	28059	88214	63372608
Atrial fibrillation	78.18	13.45	165	28035	116471	63344351
Treatment failure	75.39	13.45	3	28197	199040	63261782
Infusion related reaction	72.99	13.45	11	28189	245510	63215312
Cellulitis	70.76	13.45	129	28071	81829	63378993
Off label use	70.37	13.45	120	28080	674342	62786480
Drug intolerance	68.09	13.45	26	28174	308635	63152187
Impaired quality of life	67.56	13.45	53	28147	13730	63447092
Death	66.43	13.45	335	27865	374046	63086776
Oedema	65.28	13.45	138	28062	97484	63363338
Contraindicated product administered	64.12	13.45	10	28190	217638	63243184
Joint swelling	63.80	13.45	33	28167	327633	63133189
Hyperkalaemia	60.95	13.45	96	28104	54107	63406715
Arthropathy	60.34	13.45	15	28185	234777	63226045
Therapeutic product effect decreased	58.93	13.45	8	28192	193179	63267643
Pulmonary oedema	58.70	13.45	95	28105	54778	63406044
Poor quality sleep	54.34	13.45	55	28145	19880	63440942
Hypotension	54.09	13.45	252	27948	272352	63188470
Hepatic enzyme increased	53.82	13.45	12	28188	202316	63258506
Exposure during pregnancy	51.03	13.45	5	28195	155542	63305280
Bone density decreased	48.65	13.45	45	28155	14567	63446255
Hyperlipidaemia	47.96	13.45	51	28149	19520	63441302
Gastrointestinal haemorrhage	46.63	13.45	108	28092	81068	63379754
Alopecia	46.31	13.45	49	28151	337487	63123335
Chronic obstructive pulmonary disease	43.50	13.45	90	28110	62596	63398226
Dehydration	42.59	13.45	171	28029	173183	63287639
Cardiac failure acute	41.11	13.45	34	28166	9489	63451333
Dyspnoea exertional	40.01	13.45	85	28115	60217	63400605
Left ventricular failure	39.51	13.45	27	28173	5660	63455162
Bradycardia	39.42	13.45	95	28105	73132	63387690
Wound	39.00	13.45	12	28188	163251	63297571
Acute respiratory failure	38.65	13.45	61	28139	34424	63426398
Skin disorder	38.47	13.45	56	28144	29451	63431371
Impaired work ability	38.40	13.45	43	28157	17432	63443390
Cardiospasm	37.87	13.45	18	28182	1889	63458933
Congestive cardiomyopathy	37.47	13.45	27	28173	6155	63454667
Hypoxia	37.06	13.45	82	28118	59710	63401112
Palmoplantar keratoderma	36.99	13.45	18	28182	1989	63458833
BRASH syndrome	36.85	13.45	12	28188	457	63460365
Musculoskeletal stiffness	36.78	13.45	18	28182	184600	63276222
Discomfort	35.40	13.45	15	28185	167359	63293463
Pruritus genital	35.00	13.45	19	28181	2635	63458187
Anaemia	34.65	13.45	236	27964	293194	63167628
Dialysis	34.50	13.45	32	28168	10395	63450427
Respiratory failure	33.94	13.45	111	28089	101747	63359075
Drug hypersensitivity	33.46	13.45	54	28146	310633	63150189
Sleep terror	32.09	13.45	18	28182	2662	63458160
Therapeutic product effect incomplete	32.08	13.45	8	28192	125048	63335774
Epistaxis	31.55	13.45	87	28113	72638	63388184
Pleural effusion	31.44	13.45	102	28098	93108	63367714
Blood creatinine increased	31.33	13.45	98	28102	87746	63373076
Blood potassium decreased	31.12	13.45	62	28138	41964	63418858
Transfusion	30.99	13.45	36	28164	15181	63445641
Haemoglobin decreased	29.91	13.45	136	28064	145349	63315473
Atrial tachycardia	29.14	13.45	20	28180	4220	63456602
Ventricular tachycardia	29.12	13.45	40	28160	19939	63440883
Oral herpes	29.05	13.45	46	28154	26028	63434794
Arthralgia	28.65	13.45	143	28057	569567	62891255
Product use issue	28.05	13.45	34	28166	220486	63240336
Gout	28.04	13.45	32	28168	13239	63447583
Carotid artery occlusion	27.31	13.45	20	28180	4674	63456148
Arteriosclerosis coronary artery	26.36	13.45	25	28175	8348	63452474
Pneumonia	26.25	13.45	314	27886	456453	63004369
Pain in jaw	26.22	13.45	59	28141	43437	63417385
Blood urea increased	25.96	13.45	44	28156	26335	63434487
Tension headache	25.54	13.45	20	28180	5166	63455656
Hypersensitivity	25.28	13.45	58	28142	292627	63168195
Orthopnoea	24.24	13.45	21	28179	6240	63454582
Palpitations	23.61	13.45	106	28094	112664	63348158
Genital infection female	23.25	13.45	6	28194	98	63460724
Brain stem stroke	23.10	13.45	8	28192	369	63460453
Oxygen saturation decreased	23.03	13.45	89	28111	88496	63372326
Immunisation	22.90	13.45	11	28189	1182	63459640
Cardiorenal syndrome	22.87	13.45	10	28190	865	63459957
Chronic kidney disease	22.42	13.45	57	28143	45341	63415481
Product use in unapproved indication	22.36	13.45	28	28172	179052	63281770
Calciphylaxis	22.33	13.45	15	28185	3057	63457765
Sinusitis	22.02	13.45	42	28158	226611	63234211
Weight increased	21.99	13.45	194	28006	260598	63200224
Myocardial infarction	21.74	13.45	95	28105	99798	63361024
Blood potassium increased	21.37	13.45	33	28167	18276	63442546
Anosmia	20.68	13.45	20	28180	6840	63453982
Rectal haemorrhage	20.62	13.45	58	28142	48972	63411850
Intentional overdose	20.52	13.45	4	28196	74148	63386674
Stomatitis	20.30	13.45	19	28181	138706	63322116
Infection	20.12	13.45	45	28155	229128	63231694
Unevaluable event	19.88	13.45	59	28141	51327	63409495
Torsade de pointes	19.86	13.45	27	28173	13324	63447498
Irritable bowel syndrome	19.77	13.45	6	28194	82406	63378416
Glomerular filtration rate decreased	19.72	13.45	27	28173	13414	63447408
Atrial flutter	19.70	13.45	23	28177	9749	63451073
Psoriatic arthropathy	19.67	13.45	8	28192	91512	63369310
Ill-defined disorder	19.53	13.45	6	28194	81749	63379073
Cardiomegaly	19.52	13.45	31	28169	17583	63443239
Pain	19.47	13.45	223	27977	740405	62720417
Abdominal discomfort	19.46	13.45	75	28125	320810	63140012
Hospitalisation	19.35	13.45	82	28118	84999	63375823
Abdominal distension	19.33	13.45	83	28117	86532	63374290
Impaired healing	18.94	13.45	11	28189	102531	63358291
Paracentesis	18.79	13.45	9	28191	961	63459861
Urine output decreased	18.46	13.45	24	28176	11346	63449476
Nasopharyngitis	18.42	13.45	55	28145	254202	63206620
Urosepsis	18.36	13.45	31	28169	18493	63442329
Muscle twitching	18.29	13.45	32	28168	19636	63441186
Blood sodium decreased	18.22	13.45	36	28164	24216	63436606
Cardiac arrest	17.89	13.45	85	28115	92460	63368362
Chest pain	17.86	13.45	160	28040	215799	63245023
Chronic left ventricular failure	17.75	13.45	7	28193	466	63460356
Suicide attempt	17.47	13.45	3	28197	60915	63399907
Diaphragmatic disorder	17.34	13.45	7	28193	496	63460326
Asthenia	17.13	13.45	252	27948	383352	63077470
Pericarditis	17.02	13.45	20	28180	131559	63329263
Blood aldosterone abnormal	16.80	13.45	4	28196	46	63460776
Lactic acidosis	16.79	13.45	46	28154	38241	63422581
Osteoarthritis	16.54	13.45	11	28189	95332	63365490
Hypoaesthesia	16.53	13.45	31	28169	168362	63292460
Injection site pain	16.50	13.45	20	28180	129780	63331042
Liver function test abnormal	16.48	13.45	53	28147	48128	63412694
Generalised oedema	16.38	13.45	27	28173	15791	63445031
Fibromyalgia	15.76	13.45	8	28192	80412	63380410
Brain natriuretic peptide increased	15.35	13.45	15	28185	5198	63455624
Lung transplant	15.26	13.45	12	28188	3116	63457706
Claudication of jaw muscles	15.24	13.45	4	28196	70	63460752
Transient ischaemic attack	15.23	13.45	44	28156	37709	63423113
Unresponsive to stimuli	15.20	13.45	41	28159	33775	63427047
Facial pain	15.17	13.45	21	28179	10540	63450282
Hypokalaemia	15.02	13.45	88	28112	103716	63357106
Oxygen consumption increased	14.98	13.45	13	28187	3871	63456951
Blindness	14.86	13.45	31	28169	21668	63439154
Renal disorder	14.85	13.45	40	28160	32934	63427888
Blood cholesterol increased	14.82	13.45	12	28188	94020	63366802
Incarcerated umbilical hernia	14.33	13.45	3	28197	18	63460804
Pemphigoid	14.33	13.45	17	28183	7327	63453495
End stage renal disease	13.91	13.45	16	28184	6677	63454145
Compartment syndrome	13.90	13.45	10	28190	2274	63458548
Injection site erythema	13.89	13.45	10	28190	83164	63377658
Therapeutic response decreased	13.84	13.45	5	28195	61520	63399302
Cataract	13.76	13.45	56	28144	56997	63403825
Vasculitis	13.64	13.45	27	28173	18182	63442640
Malignant neoplasm progression	13.55	13.45	10	28190	82111	63378711
Right ventricular dysfunction	13.50	13.45	9	28191	1810	63459012
Liver injury	13.48	13.45	5	28195	60515	63400307

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	257.90	13.15	575	21052	304413	34630891
Cardiac failure congestive	172.43	13.15	234	21393	83036	34852268
Cardiac failure	121.56	13.15	209	21418	91039	34844265
Dyspnoea	121.03	13.15	506	21121	376276	34559028
Fluid retention	116.53	13.15	111	21516	26776	34908528
Hypervolaemia	88.50	13.15	83	21544	19626	34915678
Pulmonary hypertension	88.03	13.15	85	21542	20839	34914465
Oedema peripheral	73.01	13.15	200	21427	119612	34815692
Drug ineffective	60.42	13.15	120	21507	456631	34478673
Pulmonary arterial hypertension	55.80	13.15	45	21582	8694	34926610
Renal failure	54.44	13.15	191	21436	130366	34804938
Drug abuse	46.47	13.15	4	21623	99092	34836212
Oedema	46.05	13.15	93	21534	45648	34889656
Right ventricular failure	45.31	13.15	40	21587	8744	34926560
Venous pressure jugular increased	43.60	13.15	17	21610	784	34934520
Glomerular filtration rate decreased	42.41	13.15	46	21581	12915	34922389
Pulmonary oedema	40.17	13.15	90	21537	47439	34887865
Blood potassium increased	39.70	13.15	50	21577	16445	34918859
Hyperkalaemia	39.41	13.15	113	21514	69276	34866028
Toxicity to various agents	38.88	13.15	40	21587	200322	34734982
Hypotension	37.56	13.15	250	21377	221399	34713905
Blood ketone body increased	37.45	13.15	13	21614	430	34934874
International normalised ratio increased	37.10	13.15	87	21540	47240	34888064
Febrile neutropenia	34.48	13.15	21	21606	136828	34798476
Blood creatinine increased	33.72	13.15	132	21495	94844	34840460
Cardiac failure acute	31.96	13.15	36	21591	10534	34924770
Gastrointestinal haemorrhage	31.43	13.15	123	21504	88354	34846950
Venous pressure jugular decreased	31.42	13.15	7	21620	40	34935264
Renal impairment	30.09	13.15	127	21500	94386	34840918
Pyrexia	29.82	13.15	106	21521	332907	34602397
Death	28.50	13.15	373	21254	397676	34537628
Peripheral swelling	28.48	13.15	108	21519	76433	34858871
Off label use	28.14	13.15	149	21478	419375	34515929
Ventricular tachycardia	26.68	13.15	54	21573	26525	34908779
Hepatic cytolysis	25.86	13.15	38	21589	14458	34920846
Orthopnoea	25.84	13.15	23	21604	5080	34930224
Atrial fibrillation	25.04	13.15	145	21482	122248	34813056
Dyspnoea paroxysmal nocturnal	24.93	13.15	14	21613	1485	34933819
Blood pressure systolic decreased	24.21	13.15	21	21606	4482	34930822
Cardiac failure chronic	24.11	13.15	27	21600	7852	34927452
Neutropenia	23.47	13.15	38	21589	156740	34778564
Hepatic cirrhosis	22.13	13.15	39	21588	17275	34918029
Pulmonary renal syndrome	21.99	13.15	7	21620	176	34935128
Orthostatic hypotension	21.80	13.15	49	21578	25870	34909434
Vasculitic rash	21.72	13.15	11	21616	948	34934356
Dizziness	21.51	13.15	218	21409	218303	34717001
Dyspnoea exertional	21.27	13.15	67	21560	43212	34892092
Amyloidosis	20.45	13.15	14	21613	2109	34933195
Chronic kidney disease	19.52	13.15	63	21564	41147	34894157
Weight increased	18.22	13.15	109	21518	92924	34842380
Hypovolaemia	17.63	13.15	25	21602	9209	34926095
Brain natriuretic peptide abnormal	17.17	13.15	7	21620	363	34934941
Dehydration	17.02	13.15	138	21489	129831	34805473
Completed suicide	16.43	13.15	22	21605	98146	34837158
Anti-neutrophil cytoplasmic antibody positive vasculitis	16.34	13.15	9	21618	920	34934384
Blood urea increased	15.84	13.15	48	21579	30316	34904988
Transitional cell carcinoma	15.54	13.15	12	21615	2177	34933127
Acute respiratory failure	15.30	13.15	48	21579	30880	34904424
Lethargy	15.26	13.15	58	21569	41064	34894240
Bradycardia	15.17	13.15	89	21538	75329	34859975
Haemoglobin decreased	15.15	13.15	127	21500	120645	34814659
Sinus bradycardia	15.04	13.15	28	21599	12935	34922369
Weight bearing difficulty	14.96	13.15	9	21618	1086	34934218
Suicide attempt	14.95	13.15	3	21624	39113	34896191
Reaction to excipient	14.95	13.15	7	21620	508	34934796
Ischaemic cardiomyopathy	14.79	13.15	19	21608	6370	34928934
Mucosal inflammation	14.68	13.15	3	21624	38619	34896685
Incarcerated hernia	14.65	13.15	5	21622	157	34935147
Methaemoglobinaemia	14.03	13.15	14	21613	3567	34931737
Hepatic function abnormal	13.94	13.15	5	21622	44358	34890946
Hypoxia	13.77	13.15	69	21558	55026	34880278
Musculoskeletal stiffness	13.46	13.15	6	21621	46674	34888630
Hungry bone syndrome	13.38	13.15	4	21623	81	34935223
Hospitalisation	13.35	13.15	70	21557	56832	34878472
Abdominal cavity drainage	13.17	13.15	6	21621	409	34934895

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	492.27	12.51	955	42655	518449	79182329
Cardiac failure congestive	356.87	12.51	414	43196	141988	79558790
Fluid retention	258.50	12.51	250	43360	69559	79631219
Hypervolaemia	242.59	12.51	195	43415	42495	79658283
Dyspnoea	241.47	12.51	1015	42595	856010	78844768
Cardiac failure	184.11	12.51	315	43295	154527	79546251
Pulmonary hypertension	175.70	12.51	171	43439	47909	79652869
Pulmonary arterial hypertension	166.30	12.51	132	43478	28234	79672544
Right ventricular failure	161.08	12.51	120	43490	23377	79677401
Oedema peripheral	142.62	12.51	379	43231	251909	79448869
Drug ineffective	126.46	12.51	251	43359	1080662	78620116
Renal failure	119.75	12.51	308	43302	200660	79500118
Body tinea	119.17	12.51	43	43567	1811	79698967
International normalised ratio increased	102.76	12.51	174	43436	84547	79616231
Hyperkalaemia	96.38	12.51	201	43409	114197	79586581
Atrial fibrillation	94.74	12.51	280	43330	197606	79503172
Rheumatoid arthritis	93.51	12.51	5	43605	208465	79492313
Infection susceptibility increased	93.30	12.51	44	43566	3677	79697101
Inhibitory drug interaction	88.70	12.51	45	43565	4408	79696370
Off label use	87.83	12.51	233	43377	906982	78793796
Death	84.45	12.51	564	43046	565950	79134828
Oedema	83.64	12.51	195	43415	119385	79581393
Renal impairment	82.02	12.51	230	43380	157553	79543225
Hypotension	78.45	12.51	459	43151	439858	79260920
Pulmonary oedema	77.78	12.51	158	43452	88096	79612682
Cardiac failure acute	68.51	12.51	67	43543	18862	79681916
Gastrointestinal haemorrhage	66.87	12.51	205	43405	147514	79553264
Glucose tolerance impaired	66.19	12.51	46	43564	8038	79692740
Infusion related reaction	63.93	12.51	23	43587	230214	79470564
Treatment failure	63.28	12.51	9	43601	170477	79530301
Maternal exposure during pregnancy	62.08	12.51	3	43607	136535	79564243
Purpura	61.31	12.51	64	43546	19463	79681315
Bradycardia	60.30	12.51	187	43423	135370	79565408
Dehydration	59.46	12.51	281	43329	247906	79452872
Drug intolerance	58.56	12.51	36	43574	264083	79436695
Orthopnoea	57.15	12.51	46	43564	10027	79690751
Therapeutic product effect decreased	55.61	12.51	11	43599	163852	79536926
Dyspnoea exertional	54.43	12.51	136	43474	86937	79613841
Blood creatinine increased	54.00	12.51	197	43413	154860	79545918
Arthropathy	53.96	12.51	15	43595	177096	79523682
Musculoskeletal stiffness	52.98	12.51	15	43595	174993	79525785
Cellulitis	51.83	12.51	154	43456	108906	79591872
Hepatic enzyme increased	51.10	12.51	18	43592	182592	79518186
Drug abuse	51.03	12.51	13	43597	162678	79538100
Impaired quality of life	50.35	12.51	50	43560	14336	79686442
Ventricular tachycardia	48.03	12.51	84	43526	41851	79658927
Hypoxia	47.37	12.51	144	43466	103099	79597679
Joint swelling	47.14	12.51	53	43557	288593	79412185
Acute respiratory failure	47.09	12.51	102	43508	59439	79641339
Glomerular filtration rate decreased	46.97	12.51	60	43550	22642	79678136
Blood potassium increased	46.39	12.51	68	43542	29207	79671571
Intentional overdose	43.29	12.51	4	43606	105956	79594822
Bone density decreased	42.36	12.51	44	43566	13303	79687475
Congestive cardiomyopathy	41.34	12.51	41	43569	11739	79689039
Exposure during pregnancy	40.83	12.51	4	43606	101128	79599650
Poor quality sleep	40.76	12.51	56	43554	22666	79678112
Febrile neutropenia	40.41	12.51	40	43570	230959	79469819
Venous pressure jugular increased	40.36	12.51	18	43592	1322	79699456
Arthralgia	39.95	12.51	169	43441	571634	79129144
Blood urea increased	39.05	12.51	84	43526	48706	79652072
Left ventricular failure	38.63	12.51	36	43574	9545	79691233
BRASH syndrome	38.31	12.51	16	43594	1001	79699777
Cardiac failure chronic	37.68	12.51	38	43572	11097	79689681
Transfusion	37.41	12.51	52	43558	21278	79679500
Contraindicated product administered	37.00	12.51	20	43590	157518	79543260
Discomfort	35.80	12.51	12	43598	125605	79575173
Drug hypersensitivity	35.06	12.51	69	43541	298847	79401931
Epistaxis	34.93	12.51	137	43473	111378	79589400
Unevaluable event	34.92	12.51	87	43523	55498	79645280
Hyperlipidaemia	34.85	12.51	56	43554	26037	79674741
Therapeutic product effect incomplete	34.72	12.51	17	43593	141628	79559150
Product use in unapproved indication	34.66	12.51	52	43558	250307	79450471
Chronic obstructive pulmonary disease	34.47	12.51	114	43496	85305	79615473
Chronic kidney disease	33.91	12.51	96	43514	66058	79634720
Hospitalisation	33.02	12.51	120	43490	94116	79606662
Pleural effusion	32.96	12.51	162	43448	145100	79555678
Haemoglobin decreased	32.85	12.51	221	43389	221898	79478880
Pain in jaw	31.95	12.51	75	43535	46076	79654702
Dialysis	30.88	12.51	44	43566	18418	79682360
Weight increased	30.85	12.51	258	43352	277128	79423650
Blood pressure systolic decreased	30.72	12.51	34	43576	11042	79689736
Pyrexia	30.37	12.51	232	43378	678477	79022301
Injection site pain	29.74	12.51	17	43593	129821	79570957
Blood ketone body increased	29.37	12.51	12	43598	710	79700068
Alopecia	29.25	12.51	51	43559	231304	79469474
Neutropenia	29.14	12.51	72	43538	287638	79413140
Orthostatic hypotension	28.29	12.51	81	43529	56083	79644695
Venous pressure jugular decreased	27.68	12.51	7	43603	84	79700694
Sinusitis	27.64	12.51	40	43570	195461	79505317
Gout	27.59	12.51	49	43561	24700	79676078
Infection	27.31	12.51	57	43553	241655	79459123
Suicide attempt	27.24	12.51	6	43604	82926	79617852
Dyspnoea paroxysmal nocturnal	26.42	12.51	16	43594	2212	79698566
Respiratory failure	26.14	12.51	179	43431	180732	79520046
Cardiorenal syndrome	25.78	12.51	14	43596	1575	79699203
Impaired work ability	24.61	12.51	41	43569	19640	79681138
Nasopharyngitis	24.57	12.51	65	43545	253816	79446962
Wound	24.15	12.51	17	43593	116162	79584616
Genital infection female	23.96	12.51	6	43604	69	79700709
Mucosal inflammation	23.77	12.51	6	43604	75574	79625204
Hypovolaemia	23.67	12.51	38	43572	17653	79683125
Skin disorder	23.32	12.51	55	43555	33888	79666890
Coma	23.30	12.51	13	43597	100636	79600142
End stage renal disease	23.26	12.51	31	43579	12189	79688589
Oral herpes	22.81	12.51	48	43562	27406	79673372
Stomatitis	22.80	12.51	28	43582	146729	79554049
Generalised oedema	22.74	12.51	44	43566	23665	79677113
Oxygen consumption increased	22.61	12.51	20	43590	4959	79695819
Myocardial infarction	22.48	12.51	175	43435	183954	79516824
Paracentesis	22.24	12.51	12	43598	1333	79699445
Abdominal distension	22.04	12.51	126	43484	119524	79581254
Overdose	22.03	12.51	42	43568	184164	79516614
Right atrial dilatation	21.84	12.51	10	43600	781	79699997
Vasculitic rash	21.66	12.51	14	43596	2170	79698608
Urosepsis	21.64	12.51	46	43564	26449	79674329
Anaemia	21.04	12.51	351	43259	444664	79256114
Lethargy	20.87	12.51	94	43516	81198	79619580
Right ventricular dilatation	20.72	12.51	13	43597	1913	79698865
Tricuspid valve incompetence	20.67	12.51	38	43572	19674	79681104
Ascites	20.63	12.51	89	43521	75473	79625305
Confusional state	20.63	12.51	265	43345	317732	79383046
Palpitations	20.55	12.51	129	43481	126481	79574297
Hypoaesthesia	20.50	12.51	42	43568	179310	79521468
Chest pain	20.36	12.51	240	43370	282064	79418714
Toxicity to various agents	20.30	12.51	141	43469	421399	79279379
Malignant neoplasm progression	20.04	12.51	27	43583	135963	79564815
Liver function test abnormal	20.01	12.51	79	43531	64396	79636382
Blood sodium decreased	19.79	12.51	51	43559	33204	79667574
Injection site erythema	19.75	12.51	9	43601	78188	79622590
Polyuria	19.75	12.51	32	43578	14982	79685796
Psoriatic arthropathy	19.67	12.51	9	43601	77990	79622788
Pneumonia	19.66	12.51	486	43124	659760	79041018
Arteriosclerosis coronary artery	19.51	12.51	35	43575	17781	79682997
Drug monitoring procedure not performed	19.51	12.51	10	43600	1001	79699777
Renal injury	19.50	12.51	34	43576	16893	79683885
Irritable bowel syndrome	19.46	12.51	5	43605	62236	79638542
Brain natriuretic peptide increased	19.16	12.51	24	43586	8876	79691902
Amyloidosis	18.94	12.51	14	43596	2692	79698086
Calciphylaxis	18.85	12.51	16	43594	3754	79697024
Product use issue	18.61	12.51	56	43554	209766	79491012
Hypersensitivity	18.58	12.51	77	43533	262162	79438616
Cardiospasm	18.57	12.51	15	43595	3286	79697492
Seizure	18.53	12.51	48	43562	188786	79511992
Cardiomegaly	18.43	12.51	43	43567	26309	79674469
Abdominal cavity drainage	18.34	12.51	9	43601	821	79699957
Peripheral swelling	18.04	12.51	226	43384	269391	79431387
Therapeutic response decreased	18.00	12.51	7	43603	66846	79633932
Urine output decreased	17.97	12.51	34	43576	17988	79682790
Rectal haemorrhage	17.95	12.51	86	43524	76214	79624564
Unresponsive to stimuli	17.84	12.51	69	43541	55719	79645059
Blood potassium decreased	17.81	12.51	61	43549	46451	79654327
Hypokalaemia	17.63	12.51	137	43473	143903	79556875
Aspiration pleural cavity	17.62	12.51	11	43599	1606	79699172
Pain	17.58	12.51	275	43335	703527	78997251
Ill-defined disorder	17.57	12.51	7	43603	65868	79634910
Cardiac arrest	17.50	12.51	157	43453	171939	79528839
Palmoplantar keratoderma	17.02	12.51	15	43595	3701	79697077
Fibromyalgia	16.89	12.51	7	43603	64333	79636445
Completed suicide	16.89	12.51	73	43537	245694	79455084
Impaired healing	16.72	12.51	14	43596	87641	79613137
Catheterisation cardiac	16.61	12.51	18	43592	5710	79695068
Atrial tachycardia	16.60	12.51	20	43590	7113	79693665
Brain stem stroke	16.50	12.51	8	43602	711	79700067
Pruritus genital	16.46	12.51	16	43594	4470	79696308
Inappropriate schedule of product administration	16.39	12.51	30	43580	133598	79567180
Injection site swelling	16.33	12.51	3	43607	47129	79653649
Psoriasis	16.25	12.51	15	43595	89572	79611206
Drug-induced liver injury	16.10	12.51	8	43602	66109	79634669
Pericarditis	16.07	12.51	20	43590	104216	79596562
Blood aldosterone abnormal	15.97	12.51	4	43606	46	79700732
Cardiac murmur	15.96	12.51	30	43580	15794	79684984
Atrioventricular block	15.91	12.51	28	43582	14013	79686765
Syncope	15.42	12.51	158	43452	179291	79521487
Ischaemic cardiomyopathy	15.39	12.51	20	43590	7675	79693103
Transitional cell carcinoma	15.26	12.51	12	43598	2529	79698249
Blood pressure increased	15.00	12.51	62	43548	211298	79489480
Oxygen saturation decreased	14.84	12.51	121	43489	128926	79571852
Suicidal ideation	14.80	12.51	12	43598	76328	79624450
Transplant evaluation	14.70	12.51	10	43600	1687	79699091
Sleep terror	14.69	12.51	15	43595	4443	79696335
Faeces discoloured	14.66	12.51	42	43568	29085	79671693
Melaena	14.59	12.51	69	43541	60821	79639957
Cardiogenic shock	14.36	12.51	53	43557	41861	79658917
Inability to afford medication	14.34	12.51	12	43598	2761	79698017
Pulmonary renal syndrome	14.32	12.51	7	43603	633	79700145
Osteoarthritis	14.27	12.51	16	43594	87293	79613485
Blood cholesterol increased	14.06	12.51	15	43595	83705	79617073
Multiple sclerosis relapse	14.05	12.51	4	43606	46529	79654249
Osteoporosis	14.02	12.51	6	43604	54106	79646672
Claudication of jaw muscles	13.91	12.51	4	43606	80	79700698
Chronic left ventricular failure	13.82	12.51	8	43602	1018	79699760
Methaemoglobinaemia	13.62	12.51	16	43594	5541	79695237
Leukopenia	13.55	12.51	27	43583	116486	79584292
Anhedonia	13.50	12.51	27	43583	14871	79685907
Tension headache	13.28	12.51	18	43592	7193	79693585
Cardiac disorder	13.27	12.51	71	43539	65686	79635092
Mitral valve incompetence	13.24	12.51	40	43570	28525	79672253
Intentional product use issue	13.20	12.51	41	43569	152071	79548707
Cataract	13.18	12.51	68	43542	62052	79638726
Brain natriuretic peptide abnormal	12.87	12.51	7	43603	790	79699988
Generalised tonic-clonic seizure	12.85	12.51	4	43606	43906	79656872
Gastrointestinal disorder	12.82	12.51	30	43580	122175	79578603
Right ventricular dysfunction	12.80	12.51	11	43599	2624	79698154
Injection site reaction	12.79	12.51	7	43603	54778	79646000
Urticaria	12.73	12.51	55	43555	185146	79515632
Pulmonary arterial pressure increased	12.66	12.51	14	43596	4541	79696237
Hypoglycaemia	12.63	12.51	97	43513	101497	79599281
Lip swelling	12.59	12.51	50	43560	40861	79659917
Hepatic cytolysis	12.56	12.51	38	43572	27113	79673665

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C03CA02	CARDIOVASCULAR SYSTEM DIURETICS HIGH-CEILING DIURETICS Sulfonamides, plain
ATC	C03CB02	CARDIOVASCULAR SYSTEM DIURETICS HIGH-CEILING DIURETICS Sulfonamides and potassium in combination
ATC	C03EB02	CARDIOVASCULAR SYSTEM DIURETICS DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION High-ceiling diuretics and potassium-sparing agents
FDA PE	N0000175366	Increased Diuresis at Loop of Henle
FDA EPC	N0000175590	Loop Diuretic
CHEBI has role	CHEBI:35498	diuretics
CHEBI has role	CHEBI:131770	CFTR inhibitors
MeSH PA	D004232	Diuretics
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D045283	Natriuretic Agents
MeSH PA	D049994	Sodium Potassium Chloride Symporter Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Edema	indication	267038008
Edema due to Hepatic Cirrhosis	indication
Peripheral Edema due to Chronic Heart Failure	indication
Renal Disease with Edema	indication
Pulmonary Edema due to Chronic Heart Failure	indication
Hypertensive disorder	off-label use	38341003	DOID:10763
Hypercalcemia	off-label use	66931009	DOID:12678
Decompensated cardiac failure	off-label use	195111005
Anuria	contraindication	2472002	DOID:2983
Hypocalcemia	contraindication	5291005
Hypovolemia	contraindication	28560003
Hyperuricemia	contraindication	35885006	DOID:1920
Hypokalemia	contraindication	43339004
Hepatic coma	contraindication	72836002	DOID:12550
Diabetes mellitus	contraindication	73211009	DOID:9351
Oliguria	contraindication	83128009
Hearing disorder	contraindication	128540005
Hypomagnesemia	contraindication	190855004
Disease of liver	contraindication	235856003	DOID:409
Thrombocytopenic disorder	contraindication	302215000	DOID:1588

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.36	acidic
pKa2	9.88	acidic
pKa3	0.86	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Solute carrier family 12 member 1	Transporter	Q13621	S12A1_HUMAN	INHIBITOR	Ki	7.60	WOMBAT-PK	CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-1	Transporter	P05023	AT1A1_HUMAN		Kd	7.52	WOMBAT-PK
Solute carrier family 12 member 2	Transporter	P55011	S12A2_HUMAN	INHIBITOR	IC50	5.60	IUPHAR
G-protein coupled receptor 35	GPCR	Q9HC97	GPR35_HUMAN	AGONIST	EC50	5.54	IUPHAR

External reference:

ID	Source
4017794	VUID
N0000146155	NUI
D00247	KEGG_DRUG
1808	RXNORM
C0006376	UMLSCUI
CHEBI:3213	CHEBI
82U	PDB_CHEM_ID
CHEMBL1072	ChEMBL_ID
DB00887	DRUGBANK_ID
D002034	MESH_DESCRIPTOR_UI
2471	PUBCHEM_CID
4837	IUPHAR_LIGAND_ID
2943	INN_ID
0Y2S3XUQ5H	UNII
3606	MMSL
4304	MMSL
d00179	MMSL
387498005	SNOMEDCT_US
86647004	SNOMEDCT_US
4017794	VANDF
002312	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0128	TABLET	0.50 mg	ORAL	ANDA	21 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0128	TABLET	0.50 mg	ORAL	ANDA	21 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0129	TABLET	1 mg	ORAL	ANDA	21 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0129	TABLET	1 mg	ORAL	ANDA	21 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0130	TABLET	2 mg	ORAL	ANDA	21 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0130	TABLET	2 mg	ORAL	ANDA	21 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0409-1412	INJECTION, SOLUTION	0.25 mg	INTRAMUSCULAR	ANDA	20 sections
bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8361	TABLET	1 mg	ORAL	ANDA	20 sections
bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8362	TABLET	2 mg	ORAL	ANDA	20 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8393	TABLET	1 mg	ORAL	ANDA	21 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8393	TABLET	1 mg	ORAL	ANDA	21 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8394	TABLET	2 mg	ORAL	ANDA	21 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8394	TABLET	2 mg	ORAL	ANDA	21 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6007	INJECTION	0.25 mg	INTRAMUSCULAR	ANDA	22 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6007	INJECTION	0.25 mg	INTRAMUSCULAR	ANDA	22 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6007	INJECTION	0.25 mg	INTRAMUSCULAR	ANDA	22 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6008	INJECTION	0.25 mg	INTRAMUSCULAR	ANDA	22 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6008	INJECTION	0.25 mg	INTRAMUSCULAR	ANDA	22 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6008	INJECTION	0.25 mg	INTRAMUSCULAR	ANDA	22 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6161	INJECTION	0.25 mg	INTRAMUSCULAR	ANDA	22 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6161	INJECTION	0.25 mg	INTRAMUSCULAR	ANDA	22 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6162	INJECTION	0.25 mg	INTRAMUSCULAR	ANDA	22 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0641-6162	INJECTION	0.25 mg	INTRAMUSCULAR	ANDA	22 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0832-0540	TABLET	0.50 mg	ORAL	ANDA	22 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0832-0540	TABLET	0.50 mg	ORAL	ANDA	22 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0832-0541	TABLET	1 mg	ORAL	ANDA	22 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0832-0541	TABLET	1 mg	ORAL	ANDA	22 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0832-0542	TABLET	2 mg	ORAL	ANDA	22 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0832-0542	TABLET	2 mg	ORAL	ANDA	22 sections
Bumetanide	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7016	TABLET	1 mg	ORAL	ANDA	21 sections