Stem definition | Drug id | CAS RN |
---|---|---|
diuretics, piretanide derivatives | 427 | 28395-03-1 |
Dose | Unit | Route |
---|---|---|
1 | mg | O |
1 | mg | P |
1 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.10 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 45 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.46 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 90 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.16 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 2.50 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.03 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.20 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Feb. 28, 1983 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Acute kidney injury | 227.09 | 13.22 | 406 | 24744 | 227652 | 50352322 |
Cardiac failure congestive | 219.65 | 13.22 | 239 | 24911 | 84143 | 50495831 |
Fluid retention | 195.82 | 13.22 | 178 | 24972 | 50471 | 50529503 |
Hypervolaemia | 190.28 | 13.22 | 132 | 25018 | 25367 | 50554607 |
Dyspnoea | 171.83 | 13.22 | 628 | 24522 | 546980 | 50032994 |
Pulmonary arterial hypertension | 128.19 | 13.22 | 95 | 25055 | 20224 | 50559750 |
Right ventricular failure | 122.60 | 13.22 | 84 | 25066 | 15809 | 50564165 |
Pulmonary hypertension | 110.98 | 13.22 | 108 | 25042 | 33309 | 50546665 |
Drug ineffective | 109.74 | 13.22 | 149 | 25001 | 819184 | 49760790 |
Renal failure | 102.14 | 13.22 | 187 | 24963 | 106446 | 50473528 |
Oedema peripheral | 98.37 | 13.22 | 232 | 24918 | 157729 | 50422245 |
Body tinea | 92.90 | 13.22 | 32 | 25118 | 1295 | 50578679 |
Oedema | 84.15 | 13.22 | 136 | 25014 | 70045 | 50509929 |
Cardiac failure | 83.98 | 13.22 | 142 | 25008 | 75898 | 50504076 |
International normalised ratio increased | 80.21 | 13.22 | 103 | 25047 | 43049 | 50536925 |
Renal impairment | 74.07 | 13.22 | 134 | 25016 | 75527 | 50504447 |
Inhibitory drug interaction | 73.35 | 13.22 | 31 | 25119 | 2202 | 50577772 |
Rheumatoid arthritis | 72.58 | 13.22 | 8 | 25142 | 202542 | 50377432 |
Infection susceptibility increased | 72.20 | 13.22 | 32 | 25118 | 2552 | 50577422 |
Atrial fibrillation | 71.67 | 13.22 | 157 | 24993 | 101588 | 50478386 |
Off label use | 69.80 | 13.22 | 80 | 25070 | 474346 | 50105628 |
Impaired quality of life | 61.39 | 13.22 | 38 | 25112 | 6018 | 50573956 |
Hyperkalaemia | 60.10 | 13.22 | 95 | 25055 | 47994 | 50531980 |
Purpura | 57.31 | 13.22 | 44 | 25106 | 9867 | 50570107 |
Glucose tolerance impaired | 56.72 | 13.22 | 34 | 25116 | 5084 | 50574890 |
Treatment failure | 56.11 | 13.22 | 3 | 25147 | 137634 | 50442340 |
Infusion related reaction | 55.25 | 13.22 | 9 | 25141 | 169548 | 50410426 |
Pulmonary oedema | 54.81 | 13.22 | 92 | 25058 | 48846 | 50531128 |
Hypotension | 53.38 | 13.22 | 245 | 24905 | 235224 | 50344750 |
Death | 53.24 | 13.22 | 309 | 24841 | 325070 | 50254904 |
Joint swelling | 52.89 | 13.22 | 28 | 25122 | 245258 | 50334716 |
Alopecia | 49.92 | 13.22 | 30 | 25120 | 245017 | 50334957 |
Drug intolerance | 45.79 | 13.22 | 26 | 25124 | 219078 | 50360896 |
Chronic obstructive pulmonary disease | 45.27 | 13.22 | 89 | 25061 | 53346 | 50526628 |
Contraindicated product administered | 44.09 | 13.22 | 10 | 25140 | 148948 | 50431026 |
Cellulitis | 43.99 | 13.22 | 104 | 25046 | 70694 | 50509280 |
Gastrointestinal haemorrhage | 43.72 | 13.22 | 106 | 25044 | 73215 | 50506759 |
Dyspnoea exertional | 43.00 | 13.22 | 85 | 25065 | 51148 | 50528826 |
Exposure during pregnancy | 42.77 | 13.22 | 5 | 25145 | 121010 | 50458964 |
Therapeutic product effect decreased | 42.61 | 13.22 | 8 | 25142 | 136042 | 50443932 |
Arthropathy | 40.43 | 13.22 | 14 | 25136 | 157892 | 50422082 |
Bradycardia | 39.33 | 13.22 | 94 | 25056 | 64332 | 50515642 |
Cardiac failure acute | 37.87 | 13.22 | 32 | 25118 | 8218 | 50571756 |
Hypoxia | 37.23 | 13.22 | 80 | 25070 | 51043 | 50528931 |
Left ventricular failure | 35.94 | 13.22 | 25 | 25125 | 4816 | 50575158 |
BRASH syndrome | 35.59 | 13.22 | 10 | 25140 | 203 | 50579771 |
Hepatic enzyme increased | 35.48 | 13.22 | 12 | 25138 | 137368 | 50442606 |
Transfusion | 32.54 | 13.22 | 36 | 25114 | 12869 | 50567105 |
Dialysis | 32.25 | 13.22 | 31 | 25119 | 9407 | 50570567 |
Respiratory failure | 32.07 | 13.22 | 109 | 25041 | 91072 | 50488902 |
Bone density decreased | 31.62 | 13.22 | 33 | 25117 | 11042 | 50568932 |
Blood creatinine increased | 31.27 | 13.22 | 96 | 25054 | 76064 | 50503910 |
Pleural effusion | 30.99 | 13.22 | 100 | 25050 | 81354 | 50498620 |
Congestive cardiomyopathy | 30.81 | 13.22 | 24 | 25126 | 5494 | 50574480 |
Pneumonia | 29.85 | 13.22 | 303 | 24847 | 378098 | 50201876 |
Arthralgia | 29.68 | 13.22 | 115 | 25035 | 438587 | 50141387 |
Epistaxis | 29.47 | 13.22 | 84 | 25066 | 63870 | 50516104 |
Acute respiratory failure | 29.45 | 13.22 | 52 | 25098 | 28730 | 50551244 |
Haemoglobin decreased | 29.23 | 13.22 | 133 | 25017 | 127083 | 50452891 |
Hyperlipidaemia | 28.26 | 13.22 | 39 | 25111 | 17451 | 50562523 |
Drug hypersensitivity | 27.35 | 13.22 | 52 | 25098 | 250958 | 50329016 |
Gout | 27.21 | 13.22 | 31 | 25119 | 11439 | 50568535 |
Blood potassium decreased | 25.96 | 13.22 | 57 | 25093 | 36888 | 50543086 |
Anaemia | 25.89 | 13.22 | 214 | 24936 | 252242 | 50327732 |
Pain in jaw | 25.56 | 13.22 | 58 | 25092 | 38370 | 50541604 |
Poor quality sleep | 25.23 | 13.22 | 36 | 25114 | 16610 | 50563364 |
Dehydration | 24.98 | 13.22 | 145 | 25005 | 152304 | 50427670 |
Weight increased | 24.50 | 13.22 | 178 | 24972 | 201713 | 50378261 |
Musculoskeletal stiffness | 24.40 | 13.22 | 17 | 25133 | 128464 | 50451510 |
Therapeutic product effect incomplete | 23.61 | 13.22 | 8 | 25142 | 91507 | 50488467 |
Rectal haemorrhage | 23.24 | 13.22 | 56 | 25094 | 38502 | 50541472 |
Wound | 22.88 | 13.22 | 12 | 25138 | 105782 | 50474192 |
Skin disorder | 22.78 | 13.22 | 42 | 25108 | 23988 | 50555986 |
Genital infection female | 22.75 | 13.22 | 6 | 25144 | 95 | 50579879 |
Cardiorenal syndrome | 22.28 | 13.22 | 9 | 25141 | 570 | 50579404 |
Blood urea increased | 22.08 | 13.22 | 41 | 25109 | 23544 | 50556430 |
Oxygen saturation decreased | 21.85 | 13.22 | 83 | 25067 | 73165 | 50506809 |
Impaired work ability | 21.41 | 13.22 | 30 | 25120 | 13610 | 50566364 |
Discomfort | 21.03 | 13.22 | 14 | 25136 | 108366 | 50471608 |
Arteriosclerosis coronary artery | 20.46 | 13.22 | 22 | 25128 | 7614 | 50572360 |
Hospitalisation | 20.28 | 13.22 | 77 | 25073 | 67860 | 50512114 |
Chronic kidney disease | 20.06 | 13.22 | 54 | 25096 | 39717 | 50540257 |
Torsade de pointes | 20.04 | 13.22 | 27 | 25123 | 11808 | 50568166 |
Orthopnoea | 20.03 | 13.22 | 19 | 25131 | 5670 | 50574304 |
Blood potassium increased | 19.93 | 13.22 | 32 | 25118 | 16366 | 50563608 |
Drug abuse | 19.88 | 13.22 | 3 | 25147 | 59843 | 50520131 |
Unevaluable event | 19.77 | 13.22 | 59 | 25091 | 46007 | 50533967 |
Atrial flutter | 19.64 | 13.22 | 23 | 25127 | 8740 | 50571234 |
Abdominal discomfort | 19.57 | 13.22 | 55 | 25095 | 231586 | 50348388 |
Chronic left ventricular failure | 19.48 | 13.22 | 7 | 25143 | 321 | 50579653 |
Cardiomegaly | 19.22 | 13.22 | 31 | 25119 | 15914 | 50564060 |
Intentional overdose | 18.88 | 13.22 | 4 | 25146 | 62500 | 50517474 |
Abdominal distension | 18.85 | 13.22 | 79 | 25071 | 72824 | 50507150 |
Paracentesis | 18.31 | 13.22 | 9 | 25141 | 907 | 50579067 |
Urine output decreased | 17.99 | 13.22 | 24 | 25126 | 10397 | 50569577 |
Lactic acidosis | 17.54 | 13.22 | 46 | 25104 | 33309 | 50546665 |
Hypersensitivity | 17.50 | 13.22 | 52 | 25098 | 215109 | 50364865 |
Sinusitis | 17.14 | 13.22 | 37 | 25113 | 170521 | 50409453 |
Product use issue | 17.12 | 13.22 | 30 | 25120 | 149445 | 50430529 |
Pain | 17.04 | 13.22 | 195 | 24955 | 578708 | 50001266 |
Generalised oedema | 16.97 | 13.22 | 27 | 25123 | 13704 | 50566270 |
Oral herpes | 16.91 | 13.22 | 34 | 25116 | 20691 | 50559283 |
Diaphragmatic disorder | 16.91 | 13.22 | 7 | 25143 | 472 | 50579502 |
Blood aldosterone abnormal | 16.68 | 13.22 | 4 | 25146 | 42 | 50579932 |
Asthenia | 16.54 | 13.22 | 236 | 24914 | 318806 | 50261168 |
Product use in unapproved indication | 16.45 | 13.22 | 20 | 25130 | 115799 | 50464175 |
Suicide attempt | 16.28 | 13.22 | 3 | 25147 | 51729 | 50528245 |
Injection site pain | 15.95 | 13.22 | 19 | 25131 | 111005 | 50468969 |
Urosepsis | 15.89 | 13.22 | 28 | 25122 | 15437 | 50564537 |
Pemphigoid | 15.80 | 13.22 | 17 | 25133 | 5890 | 50574084 |
Brain natriuretic peptide increased | 15.71 | 13.22 | 15 | 25135 | 4512 | 50575462 |
Liver function test abnormal | 15.57 | 13.22 | 53 | 25097 | 44286 | 50535688 |
Blood sodium decreased | 15.28 | 13.22 | 33 | 25117 | 21114 | 50558860 |
Lung transplant | 15.15 | 13.22 | 12 | 25138 | 2813 | 50577161 |
Claudication of jaw muscles | 14.79 | 13.22 | 4 | 25146 | 70 | 50579904 |
Oxygen consumption increased | 14.78 | 13.22 | 13 | 25137 | 3523 | 50576451 |
Cardiac arrest | 14.63 | 13.22 | 81 | 25069 | 83570 | 50496404 |
Malignant neoplasm progression | 14.33 | 13.22 | 8 | 25142 | 68116 | 50511858 |
Rash | 14.20 | 13.22 | 144 | 25006 | 437327 | 50142647 |
Compartment syndrome | 14.16 | 13.22 | 10 | 25140 | 1972 | 50578002 |
Injection site erythema | 14.11 | 13.22 | 10 | 25140 | 74926 | 50505048 |
Incarcerated umbilical hernia | 13.99 | 13.22 | 3 | 25147 | 18 | 50579956 |
Infection | 13.92 | 13.22 | 42 | 25108 | 172912 | 50407062 |
Unresponsive to stimuli | 13.90 | 13.22 | 40 | 25110 | 30569 | 50549405 |
Stomatitis | 13.87 | 13.22 | 18 | 25132 | 101326 | 50478648 |
Right ventricular dysfunction | 13.80 | 13.22 | 9 | 25141 | 1559 | 50578415 |
Ill-defined disorder | 13.71 | 13.22 | 5 | 25145 | 54649 | 50525325 |
Brain stem stroke | 13.68 | 13.22 | 5 | 25145 | 241 | 50579733 |
Drug monitoring procedure not performed | 13.60 | 13.22 | 6 | 25144 | 473 | 50579501 |
Renal disorder | 13.52 | 13.22 | 37 | 25113 | 27468 | 50552506 |
Nasopharyngitis | 13.37 | 13.22 | 50 | 25100 | 192877 | 50387097 |
Hypoaesthesia | 13.29 | 13.22 | 27 | 25123 | 127230 | 50452744 |
Diuretic therapy | 13.23 | 13.22 | 4 | 25146 | 106 | 50579868 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Acute kidney injury | 229.78 | 13.14 | 536 | 19660 | 264731 | 29289600 |
Cardiac failure congestive | 157.82 | 13.14 | 226 | 19970 | 76355 | 29477976 |
Dyspnoea | 111.72 | 13.14 | 479 | 19717 | 326253 | 29228078 |
Cardiac failure | 106.94 | 13.14 | 193 | 20003 | 79094 | 29475237 |
Fluid retention | 106.37 | 13.14 | 104 | 20092 | 23456 | 29530875 |
Hypervolaemia | 85.90 | 13.14 | 81 | 20115 | 17464 | 29536867 |
Pulmonary hypertension | 83.72 | 13.14 | 82 | 20114 | 18526 | 29535805 |
Oedema peripheral | 65.90 | 13.14 | 187 | 20009 | 103370 | 29450961 |
Pulmonary arterial hypertension | 51.78 | 13.14 | 42 | 20154 | 7407 | 29546924 |
Drug ineffective | 51.56 | 13.14 | 107 | 20089 | 363063 | 29191268 |
Oedema | 45.16 | 13.14 | 91 | 20105 | 40392 | 29513939 |
Venous pressure jugular increased | 43.53 | 13.14 | 17 | 20179 | 712 | 29553619 |
Right ventricular failure | 41.64 | 13.14 | 38 | 20158 | 7852 | 29546479 |
Renal failure | 41.04 | 13.14 | 175 | 20021 | 118424 | 29435907 |
Glomerular filtration rate decreased | 38.72 | 13.14 | 43 | 20153 | 11223 | 29543108 |
Hyperkalaemia | 38.15 | 13.14 | 110 | 20086 | 61282 | 29493049 |
Blood ketone body increased | 38.08 | 13.14 | 13 | 20183 | 369 | 29553962 |
Toxicity to various agents | 37.51 | 13.14 | 38 | 20158 | 173623 | 29380708 |
Blood potassium increased | 37.31 | 13.14 | 48 | 20148 | 14603 | 29539728 |
Off label use | 35.18 | 13.14 | 98 | 20098 | 300702 | 29253629 |
International normalised ratio increased | 33.05 | 13.14 | 85 | 20111 | 44287 | 29510044 |
Renal impairment | 32.06 | 13.14 | 125 | 20071 | 81208 | 29473123 |
Hypotension | 31.67 | 13.14 | 234 | 19962 | 194120 | 29360211 |
Pulmonary oedema | 30.94 | 13.14 | 81 | 20115 | 42654 | 29511677 |
Venous pressure jugular decreased | 30.73 | 13.14 | 7 | 20189 | 40 | 29554291 |
Febrile neutropenia | 29.86 | 13.14 | 20 | 20176 | 112220 | 29442111 |
Gastrointestinal haemorrhage | 27.97 | 13.14 | 118 | 20078 | 79415 | 29474916 |
Ventricular tachycardia | 27.90 | 13.14 | 53 | 20143 | 22521 | 29531810 |
Pyrexia | 26.50 | 13.14 | 104 | 20092 | 287518 | 29266813 |
Cardiac failure chronic | 26.31 | 13.14 | 27 | 20169 | 6440 | 29547891 |
Peripheral swelling | 25.96 | 13.14 | 99 | 20097 | 63640 | 29490691 |
Hepatic cytolysis | 25.54 | 13.14 | 30 | 20166 | 8317 | 29546014 |
Blood pressure systolic decreased | 25.30 | 13.14 | 21 | 20175 | 3823 | 29550508 |
Blood creatinine increased | 25.22 | 13.14 | 120 | 20076 | 84982 | 29469349 |
Dyspnoea paroxysmal nocturnal | 24.59 | 13.14 | 14 | 20182 | 1380 | 29552951 |
Orthopnoea | 24.14 | 13.14 | 22 | 20174 | 4538 | 29549793 |
Neutropenia | 23.94 | 13.14 | 33 | 20163 | 131678 | 29422653 |
Cardiac failure acute | 23.22 | 13.14 | 30 | 20166 | 9162 | 29545169 |
Orthostatic hypotension | 21.88 | 13.14 | 48 | 20148 | 22581 | 29531750 |
Vasculitic rash | 21.81 | 13.14 | 11 | 20185 | 850 | 29553481 |
Pulmonary renal syndrome | 21.65 | 13.14 | 7 | 20189 | 167 | 29554164 |
Dyspnoea exertional | 21.33 | 13.14 | 64 | 20132 | 36426 | 29517905 |
Atrial fibrillation | 21.21 | 13.14 | 134 | 20062 | 105512 | 29448819 |
Weight increased | 21.20 | 13.14 | 106 | 20090 | 76561 | 29477770 |
Dizziness | 21.16 | 13.14 | 210 | 19986 | 189474 | 29364857 |
Hepatic cirrhosis | 20.49 | 13.14 | 36 | 20160 | 14408 | 29539923 |
Completed suicide | 19.16 | 13.14 | 20 | 20176 | 90226 | 29464105 |
Chronic kidney disease | 18.64 | 13.14 | 61 | 20135 | 36355 | 29517976 |
Death | 17.84 | 13.14 | 330 | 19866 | 341754 | 29212577 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 17.71 | 13.14 | 9 | 20187 | 707 | 29553624 |
Amyloidosis | 17.64 | 13.14 | 13 | 20183 | 1991 | 29552340 |
Weight bearing difficulty | 16.05 | 13.14 | 9 | 20187 | 862 | 29553469 |
Treatment failure | 15.85 | 13.14 | 3 | 20193 | 36936 | 29517395 |
Transitional cell carcinoma | 15.80 | 13.14 | 12 | 20184 | 1923 | 29552408 |
Bradycardia | 15.57 | 13.14 | 87 | 20109 | 65542 | 29488789 |
Hypovolaemia | 15.43 | 13.14 | 23 | 20173 | 8022 | 29546309 |
Reaction to excipient | 15.28 | 13.14 | 7 | 20189 | 437 | 29553894 |
Blood urea increased | 15.21 | 13.14 | 48 | 20148 | 28064 | 29526267 |
Incarcerated hernia | 14.26 | 13.14 | 5 | 20191 | 154 | 29554177 |
Suicide attempt | 14.16 | 13.14 | 3 | 20193 | 34107 | 29520224 |
Brain natriuretic peptide abnormal | 14.06 | 13.14 | 6 | 20190 | 316 | 29554015 |
Sinus bradycardia | 14.04 | 13.14 | 27 | 20169 | 11576 | 29542755 |
Condition aggravated | 13.96 | 13.14 | 157 | 20039 | 146138 | 29408193 |
Hospitalisation | 13.72 | 13.14 | 65 | 20131 | 45923 | 29508408 |
Abdominal cavity drainage | 13.66 | 13.14 | 6 | 20190 | 339 | 29553992 |
Ischaemic cardiomyopathy | 13.62 | 13.14 | 18 | 20178 | 5620 | 29548711 |
Haemoglobin decreased | 13.55 | 13.14 | 123 | 20073 | 108252 | 29446079 |
Hungry bone syndrome | 13.43 | 13.14 | 4 | 20192 | 72 | 29554259 |
Hepatic function abnormal | 13.43 | 13.14 | 5 | 20191 | 39254 | 29515077 |
Ascites | 13.38 | 13.14 | 55 | 20141 | 36564 | 29517767 |
Dehydration | 13.23 | 13.14 | 128 | 20068 | 114620 | 29439711 |
Cardiac death | 13.18 | 13.14 | 8 | 20188 | 888 | 29553443 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Acute kidney injury | 436.48 | 12.07 | 896 | 38952 | 448344 | 64010540 |
Cardiac failure congestive | 327.22 | 12.07 | 403 | 39445 | 130177 | 64328707 |
Fluid retention | 245.34 | 12.07 | 239 | 39609 | 59367 | 64399517 |
Hypervolaemia | 227.79 | 12.07 | 189 | 39659 | 38096 | 64420788 |
Dyspnoea | 227.65 | 12.07 | 960 | 38888 | 717714 | 63741170 |
Cardiac failure | 161.97 | 12.07 | 292 | 39556 | 132081 | 64326803 |
Pulmonary hypertension | 159.06 | 12.07 | 163 | 39685 | 42976 | 64415908 |
Pulmonary arterial hypertension | 154.55 | 12.07 | 127 | 39721 | 25240 | 64433644 |
Right ventricular failure | 144.61 | 12.07 | 114 | 39734 | 21357 | 64437527 |
Oedema peripheral | 143.67 | 12.07 | 366 | 39482 | 209951 | 64248933 |
Drug ineffective | 125.84 | 12.07 | 204 | 39644 | 840043 | 63618841 |
Renal failure | 101.75 | 12.07 | 294 | 39554 | 181394 | 64277490 |
Oedema | 98.88 | 12.07 | 192 | 39656 | 91743 | 64367141 |
Off label use | 95.13 | 12.07 | 153 | 39695 | 632653 | 63826231 |
International normalised ratio increased | 93.39 | 12.07 | 172 | 39676 | 78995 | 64379889 |
Hyperkalaemia | 91.94 | 12.07 | 197 | 39651 | 100932 | 64357952 |
Body tinea | 83.23 | 12.07 | 31 | 39817 | 1262 | 64457622 |
Atrial fibrillation | 81.84 | 12.07 | 262 | 39586 | 170827 | 64288057 |
Rheumatoid arthritis | 81.57 | 12.07 | 5 | 39843 | 164289 | 64294595 |
Renal impairment | 77.98 | 12.07 | 221 | 39627 | 134796 | 64324088 |
Pulmonary oedema | 70.04 | 12.07 | 152 | 39696 | 78522 | 64380362 |
Hypotension | 69.91 | 12.07 | 438 | 39410 | 380536 | 64078348 |
Infection susceptibility increased | 63.92 | 12.07 | 32 | 39816 | 2694 | 64456190 |
Drug abuse | 62.88 | 12.07 | 5 | 39843 | 132369 | 64326515 |
Death | 60.83 | 12.07 | 507 | 39341 | 482198 | 63976686 |
Bradycardia | 59.20 | 12.07 | 184 | 39664 | 118035 | 64340849 |
Gastrointestinal haemorrhage | 59.08 | 12.07 | 198 | 39650 | 132114 | 64326770 |
Inhibitory drug interaction | 58.01 | 12.07 | 33 | 39815 | 3594 | 64455290 |
Dyspnoea exertional | 56.24 | 12.07 | 134 | 39714 | 73596 | 64385288 |
Cardiac failure acute | 55.28 | 12.07 | 59 | 39789 | 16285 | 64442599 |
Orthopnoea | 54.09 | 12.07 | 45 | 39803 | 9089 | 64449795 |
Treatment failure | 53.88 | 12.07 | 5 | 39843 | 116811 | 64342073 |
Infusion related reaction | 50.84 | 12.07 | 19 | 39829 | 164448 | 64294436 |
Impaired quality of life | 47.13 | 12.07 | 36 | 39812 | 6435 | 64452449 |
Blood creatinine increased | 46.13 | 12.07 | 186 | 39662 | 135596 | 64323288 |
BRASH syndrome | 43.58 | 12.07 | 14 | 39834 | 363 | 64458521 |
Glucose tolerance impaired | 42.92 | 12.07 | 34 | 39814 | 6409 | 64452475 |
Blood potassium increased | 41.99 | 12.07 | 65 | 39783 | 25915 | 64432969 |
Dehydration | 41.41 | 12.07 | 252 | 39596 | 216511 | 64242373 |
Purpura | 41.11 | 12.07 | 52 | 39796 | 17194 | 64441690 |
Intentional overdose | 41.08 | 12.07 | 4 | 39844 | 89940 | 64368944 |
Cardiac failure chronic | 40.46 | 12.07 | 38 | 39810 | 9003 | 64449881 |
Hypoxia | 40.29 | 12.07 | 133 | 39715 | 88016 | 64370868 |
Therapeutic product effect decreased | 39.76 | 12.07 | 11 | 39837 | 115340 | 64343544 |
Joint swelling | 39.38 | 12.07 | 45 | 39803 | 215337 | 64243547 |
Transfusion | 39.36 | 12.07 | 52 | 39796 | 17942 | 64440942 |
Venous pressure jugular increased | 39.28 | 12.07 | 18 | 39830 | 1245 | 64457639 |
Drug intolerance | 39.25 | 12.07 | 35 | 39813 | 187957 | 64270927 |
Chronic obstructive pulmonary disease | 37.81 | 12.07 | 113 | 39735 | 70935 | 64387949 |
Glomerular filtration rate decreased | 37.43 | 12.07 | 53 | 39795 | 19519 | 64439365 |
Arthropathy | 37.33 | 12.07 | 14 | 39834 | 120953 | 64337931 |
Musculoskeletal stiffness | 36.80 | 12.07 | 15 | 39833 | 123191 | 64335693 |
Congestive cardiomyopathy | 36.15 | 12.07 | 38 | 39810 | 10306 | 64448578 |
Arthralgia | 35.94 | 12.07 | 146 | 39702 | 442114 | 64016770 |
Weight increased | 35.79 | 12.07 | 240 | 39608 | 213108 | 64245776 |
Hepatic enzyme increased | 35.42 | 12.07 | 18 | 39830 | 129925 | 64328959 |
Left ventricular failure | 35.05 | 12.07 | 34 | 39814 | 8383 | 64450501 |
Hospitalisation | 34.84 | 12.07 | 114 | 39734 | 75093 | 64383791 |
Febrile neutropenia | 34.52 | 12.07 | 39 | 39809 | 187618 | 64271266 |
Blood urea increased | 34.47 | 12.07 | 81 | 39767 | 44072 | 64414812 |
Exposure during pregnancy | 34.07 | 12.07 | 4 | 39844 | 77671 | 64381213 |
Blood pressure systolic decreased | 33.71 | 12.07 | 34 | 39814 | 8786 | 64450098 |
Unevaluable event | 33.47 | 12.07 | 87 | 39761 | 50402 | 64408482 |
Acute respiratory failure | 33.06 | 12.07 | 86 | 39762 | 49848 | 64409036 |
Alopecia | 30.95 | 12.07 | 34 | 39814 | 165656 | 64293228 |
Chronic kidney disease | 30.70 | 12.07 | 92 | 39756 | 57827 | 64401057 |
Pyrexia | 30.54 | 12.07 | 211 | 39637 | 558433 | 63900451 |
Haemoglobin decreased | 30.09 | 12.07 | 215 | 39633 | 194848 | 64264036 |
Product use in unapproved indication | 30.05 | 12.07 | 39 | 39809 | 176579 | 64282305 |
Cellulitis | 29.98 | 12.07 | 126 | 39722 | 93531 | 64365353 |
Pain in jaw | 29.91 | 12.07 | 73 | 39775 | 40682 | 64418202 |
Blood ketone body increased | 29.50 | 12.07 | 12 | 39836 | 620 | 64458264 |
Orthostatic hypotension | 29.42 | 12.07 | 79 | 39769 | 46659 | 64412225 |
Completed suicide | 29.32 | 12.07 | 59 | 39789 | 224355 | 64234529 |
Neutropenia | 28.81 | 12.07 | 66 | 39782 | 239558 | 64219326 |
Epistaxis | 28.34 | 12.07 | 128 | 39720 | 98003 | 64360881 |
Dialysis | 28.28 | 12.07 | 43 | 39805 | 16877 | 64442007 |
Drug hypersensitivity | 28.19 | 12.07 | 66 | 39782 | 237749 | 64221135 |
Injection site pain | 28.09 | 12.07 | 17 | 39831 | 111391 | 64347493 |
Pleural effusion | 27.97 | 12.07 | 153 | 39695 | 126406 | 64332478 |
Bone density decreased | 26.94 | 12.07 | 32 | 39816 | 9920 | 64448964 |
Ventricular tachycardia | 26.90 | 12.07 | 63 | 39785 | 34202 | 64424682 |
Venous pressure jugular decreased | 26.83 | 12.07 | 7 | 39841 | 84 | 64458800 |
Dyspnoea paroxysmal nocturnal | 26.19 | 12.07 | 16 | 39832 | 1988 | 64456896 |
Suicide attempt | 25.95 | 12.07 | 6 | 39842 | 71001 | 64387883 |
Abdominal distension | 24.64 | 12.07 | 121 | 39727 | 95873 | 64363011 |
Gout | 24.57 | 12.07 | 46 | 39802 | 21367 | 64437517 |
Cardiorenal syndrome | 24.48 | 12.07 | 13 | 39835 | 1237 | 64457647 |
Therapeutic product effect incomplete | 24.44 | 12.07 | 17 | 39831 | 103465 | 64355419 |
Pericarditis | 23.42 | 12.07 | 5 | 39843 | 62511 | 64396373 |
Genital infection female | 23.39 | 12.07 | 6 | 39842 | 67 | 64458817 |
Coma | 22.61 | 12.07 | 13 | 39835 | 87602 | 64371282 |
Contraindicated product administered | 22.58 | 12.07 | 20 | 39828 | 107809 | 64351075 |
Overdose | 22.55 | 12.07 | 40 | 39808 | 159526 | 64299358 |
Malignant neoplasm progression | 22.38 | 12.07 | 22 | 39826 | 112849 | 64346035 |
Discomfort | 22.34 | 12.07 | 11 | 39837 | 80867 | 64378017 |
Respiratory failure | 22.20 | 12.07 | 173 | 39675 | 161010 | 64297874 |
Infection | 22.15 | 12.07 | 51 | 39797 | 184829 | 64274055 |
Oxygen consumption increased | 21.94 | 12.07 | 20 | 39828 | 4561 | 64454323 |
Right atrial dilatation | 21.76 | 12.07 | 10 | 39838 | 696 | 64458188 |
Paracentesis | 21.61 | 12.07 | 12 | 39836 | 1247 | 64457637 |
Pneumonia | 21.52 | 12.07 | 474 | 39374 | 559102 | 63899782 |
Mucosal inflammation | 21.50 | 12.07 | 6 | 39842 | 62578 | 64396306 |
Hypovolaemia | 21.28 | 12.07 | 36 | 39812 | 15450 | 64443434 |
Vasculitic rash | 21.28 | 12.07 | 14 | 39834 | 1977 | 64456907 |
Toxicity to various agents | 20.97 | 12.07 | 135 | 39713 | 363378 | 64095506 |
Injection site erythema | 20.53 | 12.07 | 9 | 39839 | 70791 | 64388093 |
Drug monitoring procedure not performed | 20.31 | 12.07 | 10 | 39838 | 812 | 64458072 |
Ascites | 20.29 | 12.07 | 84 | 39764 | 61917 | 64396967 |
Right ventricular dilatation | 20.08 | 12.07 | 12 | 39836 | 1433 | 64457451 |
Seizure | 20.02 | 12.07 | 46 | 39802 | 166846 | 64292038 |
Brain natriuretic peptide increased | 19.77 | 12.07 | 24 | 39824 | 7609 | 64451275 |
Polyuria | 19.55 | 12.07 | 31 | 39817 | 12612 | 64446272 |
Sinusitis | 19.36 | 12.07 | 38 | 39810 | 145890 | 64312994 |
Confusional state | 19.20 | 12.07 | 246 | 39602 | 260898 | 64197986 |
Rectal haemorrhage | 18.87 | 12.07 | 82 | 39766 | 61735 | 64397149 |
Urosepsis | 18.87 | 12.07 | 42 | 39806 | 22052 | 64436832 |
Hyperlipidaemia | 18.86 | 12.07 | 43 | 39805 | 22933 | 64435951 |
Tricuspid valve incompetence | 18.85 | 12.07 | 36 | 39812 | 16967 | 64441917 |
Cardiac murmur | 18.78 | 12.07 | 29 | 39819 | 11534 | 64447350 |
Hypoaesthesia | 18.65 | 12.07 | 36 | 39812 | 139072 | 64319812 |
Poor quality sleep | 18.45 | 12.07 | 38 | 39810 | 18913 | 64439971 |
Abdominal cavity drainage | 18.38 | 12.07 | 9 | 39839 | 722 | 64458162 |
Liver function test abnormal | 18.29 | 12.07 | 79 | 39769 | 59322 | 64399562 |
Lethargy | 18.26 | 12.07 | 91 | 39757 | 72503 | 64386381 |
Generalised oedema | 18.21 | 12.07 | 40 | 39808 | 20813 | 64438071 |
Cardiomegaly | 18.00 | 12.07 | 43 | 39805 | 23641 | 64435243 |
Blood sodium decreased | 17.72 | 12.07 | 49 | 39799 | 29433 | 64429451 |
Cardiogenic shock | 17.65 | 12.07 | 52 | 39796 | 32375 | 64426509 |
Aspiration pleural cavity | 17.59 | 12.07 | 11 | 39837 | 1424 | 64457460 |
Renal injury | 17.52 | 12.07 | 33 | 39815 | 15396 | 64443488 |
Nasopharyngitis | 16.99 | 12.07 | 63 | 39785 | 196010 | 64262874 |
Stomatitis | 16.85 | 12.07 | 26 | 39822 | 109579 | 64349305 |
Condition aggravated | 16.76 | 12.07 | 323 | 39525 | 372103 | 64086781 |
End stage renal disease | 16.63 | 12.07 | 26 | 39822 | 10449 | 64448435 |
Blood pressure increased | 16.60 | 12.07 | 53 | 39795 | 172499 | 64286385 |
Amyloidosis | 16.27 | 12.07 | 13 | 39835 | 2481 | 64456403 |
Arteriosclerosis coronary artery | 16.15 | 12.07 | 32 | 39816 | 15497 | 64443387 |
Injection site swelling | 16.13 | 12.07 | 3 | 39845 | 41350 | 64417534 |
Multiple sclerosis relapse | 16.01 | 12.07 | 3 | 39845 | 41132 | 64417752 |
Urine output decreased | 15.98 | 12.07 | 33 | 39815 | 16459 | 64442425 |
Hepatic cytolysis | 15.89 | 12.07 | 30 | 39818 | 14019 | 64444865 |
Blood aldosterone abnormal | 15.82 | 12.07 | 4 | 39844 | 42 | 64458842 |
Unresponsive to stimuli | 15.50 | 12.07 | 67 | 39781 | 50326 | 64408558 |
Neutrophil count decreased | 15.36 | 12.07 | 15 | 39833 | 77181 | 64381703 |
Chronic left ventricular failure | 15.31 | 12.07 | 8 | 39840 | 736 | 64458148 |
Transitional cell carcinoma | 15.26 | 12.07 | 12 | 39836 | 2237 | 64456647 |
Injection site reaction | 15.08 | 12.07 | 5 | 39843 | 46659 | 64412225 |
Faeces discoloured | 14.71 | 12.07 | 42 | 39806 | 25687 | 64433197 |
Leukopenia | 14.64 | 12.07 | 25 | 39823 | 101217 | 64357667 |
Therapeutic response decreased | 14.56 | 12.07 | 7 | 39841 | 52181 | 64406703 |
Transplant evaluation | 14.38 | 12.07 | 10 | 39838 | 1547 | 64457337 |
Chest pain | 14.37 | 12.07 | 215 | 39633 | 235765 | 64223119 |
Suicidal ideation | 14.35 | 12.07 | 12 | 39836 | 66530 | 64392354 |
Blood potassium decreased | 14.23 | 12.07 | 56 | 39792 | 40343 | 64418541 |
Oxygen saturation decreased | 14.18 | 12.07 | 114 | 39734 | 107062 | 64351822 |
Pulmonary renal syndrome | 14.18 | 12.07 | 7 | 39841 | 572 | 64458312 |
Peripheral swelling | 14.11 | 12.07 | 194 | 39654 | 208959 | 64249925 |
Pain | 14.08 | 12.07 | 249 | 39599 | 553262 | 63905622 |
Wound | 13.94 | 12.07 | 16 | 39832 | 76461 | 64382423 |
Ischaemic cardiomyopathy | 13.79 | 12.07 | 19 | 39829 | 6819 | 64452065 |
Ill-defined disorder | 13.75 | 12.07 | 5 | 39843 | 44047 | 64414837 |
Catheterisation cardiac | 13.74 | 12.07 | 16 | 39832 | 4857 | 64454027 |
Claudication of jaw muscles | 13.67 | 12.07 | 4 | 39844 | 75 | 64458809 |
Hypersensitivity | 13.44 | 12.07 | 69 | 39779 | 196383 | 64262501 |
Rash | 13.40 | 12.07 | 201 | 39647 | 458348 | 64000536 |
Hepatic function abnormal | 13.38 | 12.07 | 12 | 39836 | 64301 | 64394583 |
Generalised tonic-clonic seizure | 13.36 | 12.07 | 4 | 39844 | 39853 | 64419031 |
Cardiac disorder | 13.36 | 12.07 | 69 | 39779 | 55747 | 64403137 |
Right ventricular dysfunction | 13.35 | 12.07 | 11 | 39837 | 2192 | 64456692 |
Palpitations | 13.21 | 12.07 | 110 | 39738 | 104378 | 64354506 |
Impaired work ability | 13.07 | 12.07 | 29 | 39819 | 15190 | 64443694 |
Cognitive disorder | 13.07 | 12.07 | 9 | 39839 | 55078 | 64403806 |
Psoriasis | 13.07 | 12.07 | 15 | 39833 | 71688 | 64387196 |
Anaemia | 13.04 | 12.07 | 316 | 39532 | 378364 | 64080520 |
Diaphragmatic disorder | 12.79 | 12.07 | 9 | 39839 | 1419 | 64457465 |
Atrioventricular block | 12.78 | 12.07 | 25 | 39823 | 11990 | 64446894 |
Anhedonia | 12.78 | 12.07 | 27 | 39821 | 13679 | 64445205 |
Osteoporosis | 12.76 | 12.07 | 5 | 39843 | 42075 | 64416809 |
Oral herpes | 12.51 | 12.07 | 36 | 39812 | 22116 | 64436768 |
Myocardial infarction | 12.51 | 12.07 | 157 | 39691 | 165664 | 64293220 |
Drug-induced liver injury | 12.39 | 12.07 | 7 | 39841 | 47636 | 64411248 |
Hepatic cirrhosis | 12.29 | 12.07 | 40 | 39808 | 26258 | 64432626 |
Cardiac arrest | 12.11 | 12.07 | 147 | 39701 | 153917 | 64304967 |
None
Source | Code | Description |
---|---|---|
ATC | C03CA02 | CARDIOVASCULAR SYSTEM DIURETICS HIGH-CEILING DIURETICS Sulfonamides, plain |
ATC | C03CB02 | CARDIOVASCULAR SYSTEM DIURETICS HIGH-CEILING DIURETICS Sulfonamides and potassium in combination |
ATC | C03EB02 | CARDIOVASCULAR SYSTEM DIURETICS DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION High-ceiling diuretics and potassium-sparing agents |
FDA PE | N0000175366 | Increased Diuresis at Loop of Henle |
FDA EPC | N0000175590 | Loop Diuretic |
CHEBI has role | CHEBI:35498 | diuretics |
CHEBI has role | CHEBI:131770 | CFTR inhibitors |
MeSH PA | D004232 | Diuretics |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D045283 | Natriuretic Agents |
MeSH PA | D049994 | Sodium Potassium Chloride Symporter Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Edema | indication | 267038008 | |
Edema due to Hepatic Cirrhosis | indication | ||
Peripheral Edema due to Chronic Heart Failure | indication | ||
Renal Disease with Edema | indication | ||
Pulmonary Edema due to Chronic Heart Failure | indication | ||
Hypertensive disorder | off-label use | 38341003 | DOID:10763 |
Hypercalcemia | off-label use | 66931009 | DOID:12678 |
Decompensated cardiac failure | off-label use | 195111005 | |
Anuria | contraindication | 2472002 | DOID:2983 |
Hypocalcemia | contraindication | 5291005 | |
Hypovolemia | contraindication | 28560003 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Hypokalemia | contraindication | 43339004 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Oliguria | contraindication | 83128009 | |
Hearing disorder | contraindication | 128540005 | |
Hypomagnesemia | contraindication | 190855004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.36 | acidic |
pKa2 | 9.88 | acidic |
pKa3 | 0.86 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Solute carrier family 12 member 1 | Transporter | INHIBITOR | Ki | 7.60 | WOMBAT-PK | CHEMBL | |||
Sodium/potassium-transporting ATPase subunit alpha-1 | Transporter | Kd | 7.52 | WOMBAT-PK | |||||
Solute carrier family 12 member 2 | Transporter | INHIBITOR | IC50 | 5.60 | IUPHAR | ||||
G-protein coupled receptor 35 | GPCR | AGONIST | EC50 | 5.54 | IUPHAR |
ID | Source |
---|---|
4017794 | VUID |
N0000146155 | NUI |
D00247 | KEGG_DRUG |
1808 | RXNORM |
C0006376 | UMLSCUI |
CHEBI:3213 | CHEBI |
82U | PDB_CHEM_ID |
CHEMBL1072 | ChEMBL_ID |
DB00887 | DRUGBANK_ID |
D002034 | MESH_DESCRIPTOR_UI |
2471 | PUBCHEM_CID |
4837 | IUPHAR_LIGAND_ID |
2943 | INN_ID |
0Y2S3XUQ5H | UNII |
3606 | MMSL |
4304 | MMSL |
d00179 | MMSL |
002312 | NDDF |
387498005 | SNOMEDCT_US |
86647004 | SNOMEDCT_US |
4017794 | VANDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0128 | TABLET | 0.50 mg | ORAL | ANDA | 21 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0128 | TABLET | 0.50 mg | ORAL | ANDA | 21 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0129 | TABLET | 1 mg | ORAL | ANDA | 21 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0129 | TABLET | 1 mg | ORAL | ANDA | 21 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0130 | TABLET | 2 mg | ORAL | ANDA | 21 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0185-0130 | TABLET | 2 mg | ORAL | ANDA | 21 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1412 | INJECTION, SOLUTION | 0.25 mg | INTRAMUSCULAR | ANDA | 20 sections |
bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8361 | TABLET | 1 mg | ORAL | ANDA | 20 sections |
bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8362 | TABLET | 2 mg | ORAL | ANDA | 20 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8393 | TABLET | 1 mg | ORAL | ANDA | 21 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8394 | TABLET | 2 mg | ORAL | ANDA | 21 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6007 | INJECTION | 0.25 mg | INTRAMUSCULAR | ANDA | 22 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6007 | INJECTION | 0.25 mg | INTRAMUSCULAR | ANDA | 22 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6008 | INJECTION | 0.25 mg | INTRAMUSCULAR | ANDA | 22 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6008 | INJECTION | 0.25 mg | INTRAMUSCULAR | ANDA | 22 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6161 | INJECTION | 0.25 mg | INTRAMUSCULAR | ANDA | 22 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6161 | INJECTION | 0.25 mg | INTRAMUSCULAR | ANDA | 22 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6162 | INJECTION | 0.25 mg | INTRAMUSCULAR | ANDA | 22 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6162 | INJECTION | 0.25 mg | INTRAMUSCULAR | ANDA | 22 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0540 | TABLET | 0.50 mg | ORAL | ANDA | 22 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0541 | TABLET | 1 mg | ORAL | ANDA | 22 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0542 | TABLET | 2 mg | ORAL | ANDA | 22 sections |
Bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7016 | TABLET | 1 mg | ORAL | ANDA | 21 sections |
bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 14539-700 | TABLET | 0.50 mg | ORAL | ANDA | 19 sections |
bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 14539-701 | TABLET | 1 mg | ORAL | ANDA | 19 sections |
bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 14539-702 | TABLET | 2 mg | ORAL | ANDA | 19 sections |
bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-831 | TABLET | 0.50 mg | ORAL | ANDA | 18 sections |
bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-832 | TABLET | 1 mg | ORAL | ANDA | 18 sections |
bumetanide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-833 | TABLET | 2 mg | ORAL | ANDA | 18 sections |
Bumex | HUMAN PRESCRIPTION DRUG LABEL | 1 | 30698-630 | TABLET | 0.50 mg | ORAL | NDA | 21 sections |