bumetanide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
diuretics, piretanide derivatives 427 28395-03-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bumetanide
  • bumethanide
  • bufenox
A sulfamyl diuretic.
  • Molecular weight: 364.42
  • Formula: C17H20N2O5S
  • CLOGP: 3.07
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 118.72
  • ALOGS: -4.15
  • ROTB: 8
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 mg O
1 mg P
1 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 45 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.46 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.16 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.03 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.20 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,IKBKB,ITK,JAK2,MAP2K6,MAP3K7,MAPK12,MAPK14,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 38
kinase-selectivity-class AXL,CDK9,DYRK1B,GRK2,MAP2K6,MAPK7,STK33,TEK,TTK 9
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Feb. 28, 1983 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 312.58 13.97 488 34012 319899 90274048
Cardiac failure congestive 302.83 13.97 271 34229 98423 90495524
Hypervolaemia 284.34 13.97 169 34331 32588 90561359
Dyspnoea 255.62 13.97 824 33676 880131 89713816
Fluid retention 205.57 13.97 208 34292 87883 90506064
Pulmonary arterial hypertension 166.64 13.97 111 34389 26076 90567871
Pulmonary hypertension 165.61 13.97 134 34366 42389 90551558
Right ventricular failure 148.40 13.97 92 34408 19113 90574834
Body tinea 136.20 13.97 45 34455 2103 90591844
Cardiac failure 134.18 13.97 186 34314 109310 90484637
Renal failure 126.58 13.97 199 34301 130808 90463139
Inhibitory drug interaction 115.56 13.97 44 34456 3119 90590828
Infection susceptibility increased 109.74 13.97 45 34455 3881 90590066
Maternal exposure during pregnancy 109.49 13.97 7 34493 360056 90233891
Infusion related reaction 108.58 13.97 15 34485 416765 90177182
Death 106.30 13.97 398 34102 456153 90137794
Atrial fibrillation 105.00 13.97 185 34315 133426 90460521
Systemic lupus erythematosus 104.45 13.97 9 34491 361887 90232060
Cardiospasm 101.46 13.97 41 34459 3405 90590542
Drug ineffective 101.02 13.97 238 34262 1384060 89209887
Palmoplantar keratoderma 100.77 13.97 41 34459 3466 90590481
Treatment failure 98.42 13.97 4 34496 303924 90290023
International normalised ratio increased 94.72 13.97 103 34397 47213 90546734
Cellulitis 94.16 13.97 143 34357 91194 90502753
Pruritus genital 93.60 13.97 42 34458 4516 90589431
Rheumatoid arthritis 92.22 13.97 14 34486 362600 90231347
Hepatic enzyme increased 91.58 13.97 14 34486 360722 90233225
Sleep terror 91.24 13.97 41 34459 4423 90589524
Arthropathy 91.20 13.97 15 34485 366227 90227720
Renal impairment 90.74 13.97 152 34348 105269 90488678
Oedema peripheral 89.82 13.97 258 34242 257657 90336290
Immunisation 88.90 13.97 33 34467 2180 90591767
Joint swelling 86.18 13.97 42 34458 503258 90090689
Atrial tachycardia 85.59 13.97 43 34457 5947 90588000
Dehydration 85.37 13.97 212 34288 194235 90399712
Glucose tolerance impaired 84.77 13.97 47 34453 7938 90586009
Hypotension 84.41 13.97 294 34206 325103 90268844
Carotid artery occlusion 83.27 13.97 43 34457 6299 90587648
Purpura 82.99 13.97 58 34442 14720 90579227
Drug intolerance 81.86 13.97 34 34466 447557 90146390
Off label use 79.84 13.97 190 34310 1102062 89491885
Tension headache 76.45 13.97 43 34457 7466 90586481
Therapeutic product effect decreased 74.63 13.97 9 34491 277562 90316385
Contraindicated product administered 73.55 13.97 16 34484 320123 90273824
Pulmonary oedema 72.35 13.97 103 34397 61977 90531970
Impaired quality of life 69.79 13.97 63 34437 23081 90570866
Chronic obstructive pulmonary disease 66.94 13.97 109 34391 73720 90520227
Poor quality sleep 66.29 13.97 63 34437 24630 90569317
Exposure during pregnancy 65.92 13.97 7 34493 238403 90355544
Gastrointestinal haemorrhage 65.81 13.97 121 34379 90127 90503820
Anosmia 65.68 13.97 43 34457 9805 90584142
Folliculitis 65.11 13.97 3 34497 204350 90389597
Ventricular tachycardia 64.37 13.97 62 34438 24646 90569301
Wound 64.04 13.97 18 34482 302962 90290985
Hyperkalaemia 61.75 13.97 98 34402 64866 90529081
Dyspnoea exertional 60.55 13.97 103 34397 72185 90521762
Acute respiratory failure 58.77 13.97 77 34423 42841 90551106
Musculoskeletal stiffness 58.40 13.97 20 34480 296512 90297435
Irritable bowel syndrome 57.58 13.97 6 34494 207442 90386505
Discomfort 56.68 13.97 17 34483 274318 90319629
Facial pain 56.57 13.97 44 34456 13138 90580809
Muscle twitching 56.12 13.97 57 34443 24145 90569802
Psoriatic arthropathy 55.38 13.97 10 34490 228325 90365622
Impaired healing 55.23 13.97 11 34489 234188 90359759
Myocardial infarction 54.56 13.97 123 34377 105849 90488098
Left ventricular failure 54.05 13.97 33 34467 6667 90587280
Respiratory failure 53.94 13.97 131 34369 118287 90475660
Pain in jaw 52.10 13.97 77 34423 47908 90546039
Impaired work ability 51.30 13.97 49 34451 19277 90574670
Fibromyalgia 50.10 13.97 9 34491 206260 90387687
Blindness 49.99 13.97 56 34444 26512 90567435
Stomatitis 49.96 13.97 21 34479 274677 90319270
Bone density decreased 49.92 13.97 46 34454 17299 90576648
Hyperlipidaemia 49.58 13.97 52 34448 22864 90571083
Pain of skin 48.92 13.97 44 34456 16038 90577909
Drug hypersensitivity 48.78 13.97 63 34437 463546 90130401
Congestive cardiomyopathy 48.77 13.97 32 34468 7322 90586625
Subarachnoid haemorrhage 48.67 13.97 46 34454 17858 90576089
Anaemia 48.30 13.97 263 34237 352539 90241408
Epistaxis 47.44 13.97 102 34398 85023 90508924
Bradycardia 47.33 13.97 101 34399 83746 90510201
Liver injury 47.16 13.97 5 34495 170562 90423385
Hypersensitivity 46.59 13.97 63 34437 454614 90139333
Transient ischaemic attack 46.47 13.97 69 34431 43107 90550840
Vasculitis 46.45 13.97 50 34450 22643 90571304
Therapeutic product effect incomplete 45.93 13.97 9 34491 193887 90400060
Palpitations 45.82 13.97 135 34365 136593 90457354
Hypoxia 45.32 13.97 91 34409 72308 90521639
Dialysis 44.72 13.97 36 34464 11293 90582654
Blood cholesterol increased 44.61 13.97 12 34488 208000 90385947
Cardiac failure acute 43.09 13.97 36 34464 11893 90582054
Ill-defined disorder 42.93 13.97 9 34491 184882 90409065
Arteriosclerosis coronary artery 41.09 13.97 32 34468 9571 90584376
Blood potassium decreased 39.95 13.97 68 34432 47659 90546288
Pleural effusion 39.85 13.97 113 34387 111878 90482069
Type 2 diabetes mellitus 39.50 13.97 14 34486 203230 90390717
Hypoaesthesia 38.14 13.97 38 34462 314172 90279775
Chronic kidney disease 37.47 13.97 68 34432 50123 90543824
Joint range of motion decreased 37.44 13.97 4 34496 135639 90458308
Skin disorder 37.14 13.97 57 34443 36649 90557298
Haemoglobin decreased 36.56 13.97 140 34360 161816 90432131
Lip swelling 36.34 13.97 58 34442 38552 90555395
Alopecia 35.94 13.97 85 34415 494986 90098961
Oxygen saturation decreased 35.88 13.97 106 34394 107377 90486570
Blood creatinine increased 35.78 13.97 102 34398 101284 90492663
Blood glucose increased 35.76 13.97 98 34402 95148 90498799
Hallucination 35.56 13.97 78 34422 65881 90528066
Sinusitis 34.66 13.97 48 34452 343040 90250907
Gout 34.25 13.97 37 34463 16822 90577125
Diplopia 33.97 13.97 48 34452 28666 90565281
Osteoarthritis 33.95 13.97 16 34484 195714 90398233
Eye pruritus 33.57 13.97 48 34452 28979 90564968
Nasopharyngitis 32.75 13.97 66 34434 407038 90186909
General physical health deterioration 32.66 13.97 53 34447 355062 90238885
Hospitalisation 32.49 13.97 115 34385 127985 90465962
Oedema 32.02 13.97 156 34344 200139 90393808
Orthopnoea 31.93 13.97 24 34476 6811 90587136
Sleep disorder 31.65 13.97 18 34482 198012 90395935
Transfusion 31.43 13.97 36 34464 17452 90576495
Bursitis 31.41 13.97 6 34494 131648 90462299
BRASH syndrome 31.37 13.97 15 34485 1864 90592083
Calciphylaxis 30.80 13.97 18 34482 3358 90590589
Mobility decreased 30.79 13.97 30 34470 250704 90343243
Hypokalaemia 29.30 13.97 113 34387 131003 90462944
Blood urea increased 29.06 13.97 46 34454 30367 90563580
Infection 28.87 13.97 59 34441 362035 90231912
Feeling abnormal 28.72 13.97 133 34367 167102 90426845
Oral herpes 28.37 13.97 48 34452 33476 90560471
C-reactive protein increased 28.26 13.97 17 34483 181372 90412575
Cardiac arrest 28.17 13.97 96 34404 104839 90489108
Dry skin 26.72 13.97 84 34416 87989 90505958
Blood sodium decreased 26.70 13.97 42 34458 27571 90566376
Urticaria 26.62 13.97 49 34451 312685 90281262
Night sweats 26.54 13.97 8 34492 128758 90465189
Pneumonia 25.95 13.97 363 34137 637696 89956251
Oxygen consumption increased 25.74 13.97 18 34482 4571 90589376
Hypercholesterolaemia 25.38 13.97 4 34496 100888 90493059
Grip strength decreased 24.87 13.97 3 34497 92573 90501374
Gastrointestinal disorder 24.84 13.97 37 34463 256650 90337297
Inflammation 24.80 13.97 19 34481 178573 90415374
Product use issue 24.43 13.97 56 34444 329863 90264084
Lower respiratory tract infection 24.38 13.97 36 34464 250623 90343324
Unevaluable event 24.24 13.97 60 34440 54788 90539159
Cardiac disorder 23.86 13.97 61 34439 56811 90537136
Brain stem stroke 23.50 13.97 8 34492 410 90593537
Genital infection female 23.46 13.97 6 34494 111 90593836
Hypernatraemia 23.40 13.97 23 34477 9364 90584583
Alkalosis hypochloraemic 23.35 13.97 7 34493 237 90593710
Tinnitus 23.26 13.97 51 34449 43051 90550896
Paracentesis 23.11 13.97 10 34490 985 90592962
Intentional overdose 22.98 13.97 4 34496 93830 90500117
Liver function test abnormal 22.87 13.97 56 34444 50789 90543158
Urine output decreased 22.74 13.97 26 34474 12577 90581370
Pericarditis 22.40 13.97 43 34457 270108 90323839
Chest pain 22.16 13.97 202 34298 319443 90274504
Prescribed overdose 22.15 13.97 5 34495 97620 90496327
Blood potassium increased 22.09 13.97 33 34467 20716 90573231
Cardiorenal syndrome 22.05 13.97 10 34490 1102 90592845
Lung transplant 21.92 13.97 15 34485 3677 90590270
Heart rate increased 21.80 13.97 93 34407 112809 90481138
Blister 21.66 13.97 40 34460 254958 90338989
Road traffic accident 21.62 13.97 7 34493 107619 90486328
Cardiomegaly 21.45 13.97 31 34469 18894 90575053
Hypermagnesaemia 20.94 13.97 10 34490 1239 90592708
Atrial flutter 20.79 13.97 23 34477 10735 90583212
Injury 20.53 13.97 27 34473 197322 90396625
Torsade de pointes 20.41 13.97 27 34473 15155 90578792
Chronic left ventricular failure 20.20 13.97 8 34492 630 90593317
Urosepsis 20.12 13.97 32 34468 21200 90572747
Hyperglycaemic hyperosmolar nonketotic syndrome 20.07 13.97 10 34490 1359 90592588
Generalised oedema 19.85 13.97 30 34470 19023 90574924
Product use in unapproved indication 19.70 13.97 64 34436 336172 90257775
Peripheral venous disease 19.65 13.97 4 34496 83917 90510030
Glomerular filtration rate decreased 19.58 13.97 28 34472 16904 90577043
Renal disorder 19.53 13.97 44 34456 37815 90556132
Brain natriuretic peptide increased 19.40 13.97 17 34483 5988 90587959
Urinary tract infection 19.12 13.97 189 34311 305443 90288504
Suicide attempt 18.94 13.97 3 34497 75396 90518551
Paraesthesia 18.92 13.97 42 34458 250284 90343663
Syncope 18.85 13.97 100 34400 132563 90461384
Sepsis 18.77 13.97 125 34375 179689 90414258
Pemphigoid 18.67 13.97 20 34480 9006 90584941
Disturbance in attention 18.20 13.97 49 34451 47060 90546887
Abdominal discomfort 18.13 13.97 107 34393 477221 90116726
Malignant neoplasm progression 18.12 13.97 9 34491 106861 90487086
Pericardial effusion 18.11 13.97 42 34458 36791 90557156
Wound infection 17.98 13.97 9 34491 106393 90487554
Ascites 17.79 13.97 49 34451 47691 90546256
Blood aldosterone abnormal 17.66 13.97 4 34496 43 90593904
Haemoptysis 17.50 13.97 39 34461 33281 90560666
Unresponsive to stimuli 17.16 13.97 42 34458 38079 90555868
Rash 16.90 13.97 208 34292 795892 89798055
Mental status changes 16.79 13.97 46 34454 44633 90549314
Diaphragmatic disorder 16.73 13.97 7 34493 635 90593312
Osteoporosis 16.56 13.97 8 34492 96523 90497424
Cardiac failure chronic 16.30 13.97 15 34485 5631 90588316
Musculoskeletal pain 16.25 13.97 25 34475 171226 90422721
Haemoglobin increased 16.22 13.97 17 34483 7464 90586483
End stage renal disease 16.01 13.97 18 34482 8553 90585394
Hyponatraemia 15.90 13.97 96 34404 133442 90460505
Swelling 15.87 13.97 94 34406 418964 90174983
Claudication of jaw muscles 15.80 13.97 4 34496 71 90593876
Rash papular 15.73 13.97 28 34472 20327 90573620
Autoimmune disorder 15.40 13.97 5 34495 76739 90517208
Angioedema 15.39 13.97 57 34443 64819 90529128
Pain 15.39 13.97 277 34223 996064 89597883
Inability to afford medication 15.35 13.97 12 34488 3610 90590337
Arthralgia 15.20 13.97 207 34293 778315 89815632
Hypovolaemic shock 15.17 13.97 16 34484 7078 90586869
Rectal haemorrhage 15.09 13.97 67 34433 82677 90511270
Hypovolaemia 15.03 13.97 21 34479 12410 90581537
Renal injury 14.99 13.97 19 34481 10224 90583723
Incarcerated umbilical hernia 14.79 13.97 3 34497 18 90593929
Herpes zoster 14.60 13.97 73 34427 94571 90499376
Therapeutic response decreased 14.56 13.97 8 34492 89721 90504226
Abdominal distension 14.36 13.97 92 34408 130509 90463438
Shock 14.35 13.97 33 34467 28745 90565202
Lactic acidosis 14.27 13.97 47 34453 50416 90543531
Melaena 14.26 13.97 37 34463 34760 90559187
Tricuspid valve incompetence 14.21 13.97 24 34476 16707 90577240
Ejection fraction decreased 14.09 13.97 31 34469 26222 90567725
Coronary artery disease 14.04 13.97 36 34464 33587 90560360
Drug ineffective for unapproved indication 13.99 13.97 4 34496 66640 90527307
Orthostatic hypertension 13.99 13.97 6 34494 579 90593368
Catheterisation cardiac 13.98 13.97 13 34487 4943 90589004

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 313.78 13.39 678 24603 366659 42229395
Cardiac failure congestive 216.30 13.39 260 25021 85342 42510712
Dyspnoea 150.78 13.39 588 24693 442033 42154021
Fluid retention 146.55 13.39 133 25148 31486 42564568
Cardiac failure 132.98 13.39 232 25049 106624 42489430
Hypervolaemia 106.60 13.39 97 25184 23028 42573026
Pulmonary hypertension 93.56 13.39 91 25190 23478 42572576
Oedema peripheral 84.74 13.39 223 25058 135853 42460201
Drug ineffective 81.55 13.39 157 25124 630040 41966014
Cardiac failure acute 68.39 13.39 60 25221 13573 42582481
Hypotension 64.74 13.39 313 24968 257318 42338736
Pulmonary arterial hypertension 61.74 13.39 50 25231 10137 42585917
Renal failure 61.29 13.39 206 25075 143520 42452534
Oedema 54.58 13.39 105 25176 51896 42544158
Febrile neutropenia 51.28 13.39 23 25258 185680 42410374
Right ventricular failure 49.83 13.39 43 25238 9512 42586542
Off label use 48.46 13.39 205 25076 638130 41957924
Pulmonary oedema 46.90 13.39 100 25181 53172 42542882
Atrial fibrillation 45.93 13.39 184 25097 139409 42456645
Venous pressure jugular increased 44.91 13.39 17 25264 755 42595299
Death 43.92 13.39 449 24832 470736 42125318
Hyperkalaemia 43.20 13.39 125 25156 80333 42515721
Peripheral swelling 41.68 13.39 133 25148 90137 42505917
Blood potassium increased 41.39 13.39 53 25228 18483 42577571
Renal impairment 40.08 13.39 150 25131 110078 42485976
International normalised ratio increased 39.64 13.39 88 25193 48080 42547974
Toxicity to various agents 39.16 13.39 47 25234 229089 42366965
Pyrexia 38.89 13.39 113 25168 393929 42202125
Atrioventricular block 37.91 13.39 37 25244 9578 42586476
Drug abuse 37.80 13.39 8 25273 104763 42491291
Blood creatinine increased 37.78 13.39 147 25134 109856 42486198
Dehydration 36.78 13.39 174 25107 141593 42454461
Gastrointestinal haemorrhage 36.37 13.39 134 25147 97592 42498462
Blood ketone body increased 35.52 13.39 13 25268 525 42595529
Dizziness 35.44 13.39 261 25020 248993 42347061
Glomerular filtration rate decreased 35.33 13.39 46 25235 16305 42579749
Venous pressure jugular decreased 31.86 13.39 7 25274 39 42596015
Neutropenia 29.91 13.39 45 25236 199386 42396668
Orthostatic hypotension 26.45 13.39 57 25224 30513 42565541
Ventricular tachycardia 25.82 13.39 56 25225 30104 42565950
Orthopnoea 25.49 13.39 23 25258 5394 42590660
Hepatic cirrhosis 24.73 13.39 43 25238 19659 42576395
Dyspnoea paroxysmal nocturnal 24.47 13.39 14 25267 1606 42594448
Amyloidosis 24.02 13.39 16 25265 2403 42593651
Renal phospholipidosis 23.38 13.39 7 25274 149 42595905
Blood pressure systolic decreased 23.12 13.39 21 25260 4966 42591088
Chronic kidney disease 23.07 13.39 71 25210 47170 42548884
BRASH syndrome 22.92 13.39 14 25267 1811 42594243
Cardiac failure chronic 22.30 13.39 28 25253 9573 42586481
Eosinophilia 21.53 13.39 55 25226 32844 42563210
Vasculitic rash 21.45 13.39 11 25270 1015 42595039
Dyspnoea exertional 21.43 13.39 72 25209 50076 42545978
Weight increased 20.09 13.39 121 25160 107862 42488192
Fall 20.08 13.39 220 25061 234300 42361754
Pulmonary renal syndrome 20.08 13.39 7 25274 245 42595809
Presyncope 19.66 13.39 42 25239 22345 42573709
Mucosal inflammation 19.47 13.39 3 25278 49371 42546683
Abdominal cavity drainage 19.35 13.39 8 25273 449 42595605
Lethargy 18.88 13.39 66 25215 46824 42549230
Bradycardia 18.67 13.39 100 25181 85384 42510670
Suicide attempt 17.73 13.39 3 25278 46097 42549957
Chest pain 17.49 13.39 142 25139 139388 42456666
Brain natriuretic peptide abnormal 17.10 13.39 7 25274 383 42595671
Inappropriate schedule of product administration 17.08 13.39 19 25262 95883 42500171
Hypovolaemia 17.00 13.39 27 25254 11458 42584596
Acute respiratory failure 15.90 13.39 55 25226 38803 42557251
Blood urea increased 15.74 13.39 49 25232 32744 42563310
Sclerotherapy 15.73 13.39 4 25277 45 42596009
Malignant neoplasm progression 15.71 13.39 25 25256 108375 42487679
Hepatic cytolysis 15.66 13.39 43 25238 26801 42569253
Cardiomegaly 15.35 13.39 32 25249 16734 42579320
Unevaluable event 15.33 13.39 50 25231 34238 42561816
Ischaemic cardiomyopathy 15.11 13.39 19 25262 6503 42589551
Intentional product misuse 15.08 13.39 9 25272 61891 42534163
Hepatic function abnormal 14.83 13.39 6 25275 51561 42544493
Myelosuppression 14.77 13.39 3 25278 40458 42555596
Incarcerated hernia 14.74 13.39 5 25276 161 42595893
Haemoglobin decreased 14.59 13.39 131 25150 132340 42463714
Renal tubular necrosis 14.49 13.39 33 25248 18321 42577733
Epistaxis 14.47 13.39 78 25203 66748 42529306
Sinus bradycardia 14.37 13.39 29 25252 14824 42581230
Bacterial diarrhoea 14.31 13.39 5 25276 176 42595878
Liver function test abnormal 14.27 13.39 47 25234 32344 42563710
Weight bearing difficulty 14.22 13.39 9 25272 1239 42594815
Completed suicide 14.22 13.39 22 25259 96443 42499611
Diastolic dysfunction 14.09 13.39 19 25262 6964 42589090
Treatment failure 14.04 13.39 10 25271 62614 42533440
Transitional cell carcinoma 13.93 13.39 12 25269 2646 42593408
Faeces discoloured 13.89 13.39 31 25250 16983 42579071
Rheumatoid arthritis 13.82 13.39 4 25277 42436 42553618
Loss of consciousness 13.82 13.39 98 25183 92256 42503798
Overdose 13.69 13.39 26 25255 105238 42490816
Hospitalisation 13.63 13.39 83 25198 74247 42521807
Reaction to excipient 13.56 13.39 7 25274 655 42595399
Catheter culture positive 13.47 13.39 3 25278 18 42596036
Blood pressure increased 13.41 13.39 25 25256 101903 42494151

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 694.67 12.84 1143 50954 634287 109902915
Cardiac failure congestive 469.38 12.84 459 51638 150541 110386661
Dyspnoea 325.27 12.84 1199 50898 1105673 109431529
Hypervolaemia 320.33 12.84 230 51867 49230 110487972
Fluid retention 295.30 12.84 288 51809 94019 110443183
Cardiac failure 226.26 12.84 354 51743 187272 110349930
Pulmonary hypertension 210.10 12.84 188 51909 55032 110482170
Pulmonary arterial hypertension 198.44 12.84 146 51951 32422 110504780
Right ventricular failure 180.27 12.84 126 51971 25828 110511374
Atrial fibrillation 156.90 12.84 339 51758 229303 110307899
Hypotension 151.60 12.84 566 51531 523283 110013919
Renal failure 149.70 12.84 330 51767 226244 110310958
Death 148.81 12.84 687 51410 698182 109839020
Oedema peripheral 144.73 12.84 410 51687 328250 110208952
Drug ineffective 136.75 12.84 324 51773 1520216 109016986
Dehydration 133.25 12.84 359 51738 279152 110258050
Body tinea 123.68 12.84 44 52053 2071 110535131
Cardiac failure acute 122.59 12.84 97 52000 23981 110513221
International normalised ratio increased 120.54 12.84 175 51922 86597 110450605
Off label use 112.72 12.84 349 51748 1499836 109037366
Rheumatoid arthritis 110.35 12.84 8 52089 299605 110237597
Renal impairment 109.53 12.84 261 51836 188184 110349018
Hyperkalaemia 108.60 12.84 214 51883 135582 110401620
Pulmonary oedema 102.40 12.84 176 51921 100483 110436719
Infusion related reaction 99.75 12.84 28 52069 381134 110156068
Maternal exposure during pregnancy 96.22 12.84 6 52091 254877 110282325
Infection susceptibility increased 95.61 12.84 45 52052 4353 110532849
Inhibitory drug interaction 93.55 12.84 46 52051 4901 110532301
Gastrointestinal haemorrhage 92.69 12.84 226 51871 165292 110371910
Treatment failure 92.52 12.84 11 52086 277223 110259979
Hepatic enzyme increased 88.88 12.84 21 52076 320871 110216331
Systemic lupus erythematosus 87.63 12.84 9 52088 254329 110282873
Arthropathy 87.58 12.84 15 52082 287507 110249695
Drug intolerance 85.99 12.84 42 52055 406470 110130732
Cellulitis 80.29 12.84 181 51916 125835 110411367
Bradycardia 79.37 12.84 205 51892 155312 110381890
Ventricular tachycardia 77.04 12.84 106 51991 49903 110487299
Musculoskeletal stiffness 76.14 12.84 19 52078 279803 110257399
Therapeutic product effect decreased 76.07 12.84 12 52085 244304 110292898
Joint swelling 70.39 12.84 63 52034 442782 110094420
Blood creatinine increased 67.93 12.84 215 51882 182674 110354528
Glucose tolerance impaired 66.54 12.84 47 52050 9790 110527412
Orthopnoea 66.20 12.84 49 52048 10972 110526230
Dyspnoea exertional 65.76 12.84 149 51948 103911 110433291
Purpura 64.43 12.84 68 52029 24320 110512882
Folliculitis 63.10 12.84 4 52093 167649 110369553
Acute respiratory failure 63.06 12.84 121 51976 75139 110462063
Cardiospasm 62.03 12.84 35 52062 4932 110532270
Palmoplantar keratoderma 59.39 12.84 35 52062 5352 110531850
Irritable bowel syndrome 58.71 12.84 5 52092 164210 110372992
Psoriatic arthropathy 58.31 12.84 11 52086 196750 110340452
Discomfort 57.59 12.84 15 52082 214692 110322510
Exposure during pregnancy 57.47 12.84 6 52091 167418 110369784
Drug hypersensitivity 57.40 12.84 78 52019 454012 110083190
Oedema 56.53 12.84 222 51875 209754 110327448
Pruritus genital 55.68 12.84 36 52061 6486 110530716
Immunisation 55.47 12.84 28 52069 3155 110534047
Sleep terror 55.24 12.84 36 52061 6574 110530628
BRASH syndrome 54.12 12.84 29 52068 3694 110533508
Fibromyalgia 54.09 12.84 8 52089 170901 110366301
Stomatitis 54.04 12.84 30 52067 270212 110266990
Hypoxia 53.44 12.84 158 51939 129357 110407845
Poor quality sleep 53.34 12.84 66 52031 28011 110509191
Atrial tachycardia 53.33 12.84 40 52057 9138 110528064
Myocardial infarction 53.26 12.84 205 51892 191878 110345324
Tension headache 51.66 12.84 40 52057 9578 110527624
Chronic kidney disease 51.30 12.84 112 51985 76179 110461023
Congestive cardiomyopathy 51.28 12.84 47 52050 14172 110523030
Blood potassium increased 50.50 12.84 70 52027 33179 110504023
Febrile neutropenia 50.38 12.84 45 52052 316722 110220480
Left ventricular failure 49.80 12.84 42 52055 11347 110525855
Impaired healing 48.62 12.84 16 52081 196701 110340501
Atrioventricular block 48.08 12.84 49 52048 16828 110520374
Carotid artery occlusion 47.54 12.84 38 52059 9527 110527675
Therapeutic product effect incomplete 47.48 12.84 23 52074 223782 110313420
Intentional overdose 47.46 12.84 4 52093 132497 110404705
Nasopharyngitis 46.61 12.84 71 52026 394290 110142912
Epistaxis 46.33 12.84 151 51946 130221 110406981
Blood cholesterol increased 45.72 12.84 15 52082 184770 110352432
Dialysis 45.37 12.84 51 52046 19568 110517634
Cardiomegaly 45.25 12.84 62 52035 29068 110508134
Pleural effusion 44.71 12.84 184 51913 177525 110359677
Blood urea increased 44.38 12.84 87 52010 54870 110482332
Wound 44.08 12.84 28 52069 234409 110302793
Glomerular filtration rate decreased 44.03 12.84 61 52036 28895 110508307
Ill-defined disorder 43.93 12.84 10 52087 156843 110380359
Chronic obstructive pulmonary disease 43.92 12.84 132 51965 109026 110428176
Unevaluable event 43.34 12.84 90 52007 59137 110478065
Haemoglobin decreased 43.09 12.84 231 51866 248496 110288706
Respiratory failure 42.91 12.84 208 51889 215124 110322078
Bone density decreased 42.86 12.84 45 52052 15997 110521205
Venous pressure jugular increased 42.79 12.84 18 52079 1334 110535868
Joint range of motion decreased 42.77 12.84 4 52093 121828 110415374
Pain in jaw 42.52 12.84 82 52015 51095 110486107
Liver function test abnormal 41.64 12.84 97 52000 68853 110468349
Cardiac failure chronic 40.99 12.84 41 52056 13770 110523432
Orthostatic hypotension 40.89 12.84 94 52003 66155 110471047
Hypoaesthesia 40.68 12.84 53 52044 314170 110223032
Sinusitis 40.55 12.84 48 52049 296640 110240562
Impaired quality of life 39.44 12.84 59 52038 29958 110507244
Liver injury 39.40 12.84 11 52086 150402 110386800
Transfusion 39.24 12.84 54 52043 25418 110511784
Bursitis 39.05 12.84 7 52090 129911 110407291
Hospitalisation 37.80 12.84 150 51947 142343 110394859
Product use in unapproved indication 37.07 12.84 99 51998 447278 110089924
Anosmia 36.97 12.84 37 52060 12435 110524767
Hypersensitivity 36.91 12.84 85 52012 403913 110133289
Osteoarthritis 35.46 12.84 21 52076 182602 110354600
Urticaria 34.32 12.84 61 52036 318796 110218406
Chest pain 34.17 12.84 298 51799 376077 110161125
Infection 34.07 12.84 75 52022 362125 110175077
Inflammation 33.77 12.84 25 52072 193213 110343989
Pneumonia 33.74 12.84 590 51507 876124 109661078
Drug abuse 33.61 12.84 21 52076 177390 110359812
Hypokalaemia 33.34 12.84 172 51925 182276 110354926
Palpitations 33.31 12.84 156 51941 159056 110378146
Alopecia 33.11 12.84 77 52020 364676 110172526
Pyrexia 32.98 12.84 268 51829 897997 109639205
Anaemia 32.43 12.84 397 51700 546689 109990513
Facial pain 32.31 12.84 38 52059 15301 110521901
Gastrointestinal disorder 32.15 12.84 40 52057 241912 110295290
Gout 32.12 12.84 60 52037 36506 110500696
Arthralgia 31.73 12.84 226 51871 779406 109757796
Oxygen consumption increased 31.31 12.84 24 52073 5661 110531541
Muscle twitching 31.29 12.84 53 52044 29882 110507320
Blood pressure systolic decreased 31.18 12.84 35 52062 13406 110523796
Myelosuppression 30.83 12.84 4 52093 94336 110442866
Sleep disorder 30.65 12.84 29 52068 198615 110338587
Hyperlipidaemia 30.47 12.84 58 52039 35790 110501412
Lip swelling 30.29 12.84 71 52026 50596 110486606
Lethargy 30.25 12.84 105 51992 93471 110443731
Suicide attempt 30.16 12.84 6 52091 103388 110433814
Contraindicated product administered 29.99 12.84 44 52053 248223 110288979
Presyncope 29.77 12.84 69 52028 48818 110488384
Neutropenia 29.46 12.84 85 52012 374535 110162667
Drug-induced liver injury 29.26 12.84 10 52087 120057 110417145
Subarachnoid haemorrhage 28.97 12.84 51 52046 29651 110507551
Blood ketone body increased 28.70 12.84 12 52085 876 110536326
Venous pressure jugular decreased 28.41 12.84 7 52090 88 110537114
Arteriosclerosis coronary artery 28.30 12.84 46 52051 25072 110512130
Prescribed overdose 27.94 12.84 4 52093 87577 110449625
Polyuria 27.92 12.84 38 52059 17700 110519502
Impaired work ability 27.91 12.84 47 52050 26372 110510830
Blood sodium decreased 27.77 12.84 58 52039 38261 110498941
Cardiac arrest 27.71 12.84 173 51924 196580 110340622
Hypovolaemia 27.62 12.84 42 52055 21632 110515570
Chronic left ventricular failure 27.37 12.84 13 52084 1283 110535919
Grip strength decreased 27.18 12.84 3 52094 80171 110457031
Mucosal inflammation 27.18 12.84 6 52091 96135 110441067
Dyspnoea paroxysmal nocturnal 26.91 12.84 16 52081 2486 110534716
Vasculitis 26.82 12.84 55 52042 35818 110501384
Urosepsis 26.53 12.84 50 52047 30625 110506577
Ascites 26.49 12.84 100 51997 92708 110444494
Malignant neoplasm progression 26.33 12.84 26 52071 174541 110362661
Calciphylaxis 26.01 12.84 19 52078 4168 110533034
Syncope 25.42 12.84 173 51924 202363 110334839
Cardiorenal syndrome 25.27 12.84 14 52083 1904 110535298
Generalised oedema 25.26 12.84 49 52048 30655 110506547
Blood potassium decreased 25.22 12.84 69 52028 54045 110483157
Abdominal cavity drainage 25.11 12.84 11 52086 900 110536302
Urine output decreased 24.60 12.84 38 52059 19838 110517364
Pericarditis 24.40 12.84 41 52056 219073 110318129
Product use issue 24.30 12.84 71 52026 311624 110225578
Ejection fraction decreased 24.12 12.84 57 52040 40823 110496379
Type 2 diabetes mellitus 23.85 12.84 29 52068 177203 110359999
Genital infection female 23.76 12.84 6 52091 84 110537118
Paracentesis 23.48 12.84 12 52085 1388 110535814
Amyloidosis 23.39 12.84 16 52081 3165 110534037
Cardiac disorder 23.28 12.84 84 52013 76196 110461006
Vasculitic rash 23.15 12.84 14 52083 2243 110534959
Haemoptysis 23.00 12.84 80 52017 71274 110465928
Pericardial effusion 22.83 12.84 69 52028 57148 110480054
Unresponsive to stimuli 22.76 12.84 74 52023 63716 110473486
Night sweats 22.55 12.84 18 52079 133965 110403237
Mobility decreased 22.44 12.84 49 52048 237373 110299829
Brain natriuretic peptide increased 22.34 12.84 27 52070 11182 110526020
Skin disorder 22.31 12.84 57 52040 42856 110494346
Coma 22.25 12.84 14 52083 117855 110419347
Peripheral swelling 22.13 12.84 289 51808 403745 110133457
Fall 22.05 12.84 403 51694 603079 109934123
Injection site pain 22.01 12.84 31 52066 177891 110359311
Loss of consciousness 21.91 12.84 163 51934 196143 110341059
Eye pruritus 21.89 12.84 48 52049 32727 110504475
Osteoporosis 21.68 12.84 7 52090 87145 110450057
Pain of skin 21.65 12.84 36 52061 19993 110517209
Musculoskeletal pain 21.55 12.84 33 52064 182990 110354212
Oxygen saturation decreased 21.46 12.84 137 51960 156845 110380357
Hypercholesterolaemia 21.39 12.84 8 52089 90829 110446373
Drug monitoring procedure not performed 21.15 12.84 11 52086 1319 110535883
Coronary artery disease 21.08 12.84 78 52019 71612 110465590
Dizziness 21.07 12.84 453 51644 697740 109839462
General physical health deterioration 21.03 12.84 116 51981 425179 110112023
Oral herpes 20.96 12.84 50 52047 36030 110501172
Right atrial dilatation 20.84 12.84 10 52087 1010 110536192
Tricuspid valve incompetence 20.75 12.84 39 52058 23834 110513368
Renal injury 20.72 12.84 34 52063 18679 110518523
Blindness 20.70 12.84 50 52047 36309 110500893
Overdose 20.69 12.84 50 52047 233744 110303458
Cardiac amyloidosis 20.22 12.84 14 52083 2823 110534379
Transient ischaemic attack 19.99 12.84 71 52026 63911 110473291
Right ventricular dilatation 19.95 12.84 13 52084 2374 110534828
Inability to afford medication 19.85 12.84 16 52081 4060 110533142
End stage renal disease 19.82 12.84 36 52061 21437 110515765
Psoriasis 19.82 12.84 22 52075 139971 110397231
Drug ineffective for unapproved indication 19.71 12.84 12 52085 102826 110434376
Catheterisation cardiac 19.53 12.84 19 52078 6172 110531030
Hallucination 19.49 12.84 97 52000 101335 110435867
Paraesthesia 19.43 12.84 66 52031 276455 110260747
Wheezing 19.27 12.84 59 52038 255171 110282031
Hypernatraemia 19.20 12.84 32 52065 17801 110519401
Ischaemic cardiomyopathy 18.82 12.84 21 52076 7990 110529212
Melaena 18.73 12.84 73 52024 68684 110468518
Acidosis 18.59 12.84 36 52061 22495 110514707
Renal phospholipidosis 18.53 12.84 7 52090 391 110536811
Aspiration pleural cavity 18.40 12.84 11 52086 1726 110535476
Abdominal distension 18.20 12.84 143 51954 174960 110362242
C-reactive protein increased 18.20 12.84 48 52049 217871 110319331
Eosinophilia 17.85 12.84 64 52033 57872 110479330
Pain 17.75 12.84 330 51767 954625 109582577
Blood glucose increased 17.72 12.84 115 51982 132381 110404821
Inappropriate schedule of product administration 17.66 12.84 44 52053 203593 110333609
Injection site reaction 17.63 12.84 10 52087 89060 110448142
Faeces discoloured 17.56 12.84 45 52052 33903 110503299
Road traffic accident 17.37 12.84 15 52082 107383 110429819
Peripheral venous disease 17.30 12.84 9 52088 84108 110453094
Brain stem stroke 17.00 12.84 8 52089 773 110536429
Blood aldosterone abnormal 16.81 12.84 4 52093 43 110537159
Autoimmune disorder 16.76 12.84 5 52092 65478 110471724
Dry mouth 16.73 12.84 44 52053 199904 110337298
Red blood cell sedimentation rate increased 16.67 12.84 8 52089 78294 110458908
Blood pressure increased 16.61 12.84 64 52033 258309 110278893
Suicidal ideation 16.60 12.84 12 52085 93925 110443277
Sclerotherapy 16.56 12.84 4 52093 46 110537156
Cardiogenic shock 16.54 12.84 62 52035 57276 110479926
Hypermagnesaemia 16.48 12.84 10 52087 1613 110535589
Leukopenia 16.42 12.84 28 52069 148763 110388439
Haemorrhage 16.40 12.84 96 52001 106596 110430606
Blood loss anaemia 16.36 12.84 30 52067 17995 110519207
Chronic respiratory failure 16.26 12.84 14 52083 3889 110533313
Mental status changes 16.22 12.84 75 52022 76047 110461155
Intentional product use issue 16.20 12.84 61 52036 247845 110289357
Therapeutic response decreased 16.20 12.84 13 52084 96486 110440716
Hypophagia 16.10 12.84 58 52039 52568 110484634
Weight increased 15.93 12.84 282 51815 419362 110117840
Alkalosis hypochloraemic 15.74 12.84 7 52090 594 110536608
Anhedonia 15.71 12.84 27 52070 15401 110521801
Nail disorder 15.62 12.84 4 52093 57931 110479271
Haemodialysis 15.47 12.84 29 52068 17690 110519512
Injection site erythema 15.42 12.84 13 52084 94163 110443039
Transplant evaluation 15.35 12.84 10 52087 1825 110535377
Feeling abnormal 15.31 12.84 141 51956 180570 110356632
Torsade de pointes 14.98 12.84 33 52064 22567 110514635
Product quality issue 14.84 12.84 9 52088 77290 110459912
Rash 14.84 12.84 285 51812 820679 109716523
Blister 14.82 12.84 56 52041 227320 110309882
Transitional cell carcinoma 14.49 12.84 12 52085 3163 110534039
Lung transplant 14.43 12.84 15 52082 5271 110531931
Fear 14.41 12.84 33 52064 23160 110514042
Generalised tonic-clonic seizure 14.31 12.84 4 52093 54676 110482526
Abdominal discomfort 14.18 12.84 118 51979 393740 110143462
Lower limb fracture 14.15 12.84 9 52088 75339 110461863
Dizziness postural 14.13 12.84 25 52072 14584 110522618
Mitral valve incompetence 14.06 12.84 41 52056 33288 110503914
Hypomagnesaemia 14.00 12.84 61 52036 60309 110476893
Pulmonary congestion 13.95 12.84 39 52058 30927 110506275
Hypoglycaemia 13.87 12.84 98 51999 116006 110421196
Gait inability 13.85 12.84 27 52070 136349 110400853
Obesity 13.77 12.84 20 52077 113331 110423871
Foot deformity 13.75 12.84 3 52094 48477 110488725
Claudication of jaw muscles 13.74 12.84 4 52093 98 110537104
Pulmonary renal syndrome 13.50 12.84 7 52090 834 110536368
Iron deficiency anaemia 13.49 12.84 39 52058 31520 110505682
Acute left ventricular failure 13.30 12.84 10 52087 2291 110534911
Oliguria 13.24 12.84 28 52069 18629 110518573
Pickwickian syndrome 13.13 12.84 6 52091 542 110536660
Toxicity to various agents 13.10 12.84 154 51943 480401 110056801
Asthma 13.06 12.84 67 52030 250224 110286978
Pulmonary arterial pressure increased 13.02 12.84 14 52083 5113 110532089
Hip arthroplasty 13.00 12.84 5 52092 55808 110481394
Brain natriuretic peptide abnormal 12.99 12.84 7 52090 901 110536301
Haematuria 12.96 12.84 75 52022 82930 110454272
Atrioventricular block complete 12.95 12.84 29 52068 20053 110517149
Hyponatraemia 12.88 12.84 158 51939 217495 110319707
Depression 12.86 12.84 92 52005 317243 110219959

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03CA02 CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Sulfonamides, plain
ATC C03CB02 CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Sulfonamides and potassium in combination
ATC C03EB02 CARDIOVASCULAR SYSTEM
DIURETICS
DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
High-ceiling diuretics and potassium-sparing agents
FDA PE N0000175366 Increased Diuresis at Loop of Henle
CHEBI has role CHEBI:35498 diuretic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:131770 EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor
CHEBI has role CHEBI:231911 renoprotective agent
MeSH PA D004232 Diuretics
MeSH PA D045283 Natriuretic Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D049994 Sodium Potassium Chloride Symporter Inhibitors
FDA EPC N0000175590 Loop Diuretic

Related Drugs by ATC class:

C03CA Sulfonamides, plain 3 drugs
furosemidepiretanidetorsemide
C03CB Sulfonamides and potassium in combination 1 drug
furosemide
C03EB High-ceiling diuretics and potassium-sparing agents 2 drugs
furosemidetorsemide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Edema indication 267038008
Edema due to Hepatic Cirrhosis indication
Peripheral Edema due to Chronic Heart Failure indication
Renal Disease with Edema indication
Pulmonary Edema due to Chronic Heart Failure indication
Hypertensive disorder off-label use 38341003 DOID:10763
Hypercalcemia off-label use 66931009 DOID:12678
Decompensated cardiac failure off-label use 195111005
Anuria contraindication 2472002 DOID:2983
Hypocalcemia contraindication 5291005
Hypovolemia contraindication 28560003
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Oliguria contraindication 83128009
Hearing disorder contraindication 128540005
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Thrombocytopenic disorder contraindication 302215000 DOID:1588




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.36 acidic
pKa2 9.88 acidic
pKa3 0.86 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.5MG/SPRAY ENBUMYST CORSTASIS THERAP N219500 Sept. 12, 2025 RX SPRAY NASAL 11260038 Dec. 4, 2040 INTRANASAL BUMETANIDE FOR THE TREATMENT OF EDEMA
0.5MG/SPRAY ENBUMYST CORSTASIS THERAP N219500 Sept. 12, 2025 RX SPRAY NASAL 12329731 Dec. 4, 2040 INTRANASAL BUMETANIDE FOR THE TREATMENT OF EDEMA
0.5MG/SPRAY ENBUMYST CORSTASIS THERAP N219500 Sept. 12, 2025 RX SPRAY NASAL 12558330 May 14, 2045 INTRANASAL BUMETANIDE FOR THE TREATMENT OF EDEMA

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Solute carrier family 12 member 1 Transporter INHIBITOR Ki 7.60 WOMBAT-PK CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-1 Transporter Kd 7.52 WOMBAT-PK
Carbonic anhydrase 2 Enzyme Ki 5.16 CHEMBL
Solute carrier family 12 member 2 Transporter INHIBITOR IC50 5.60 IUPHAR
G-protein coupled receptor 35 GPCR AGONIST EC50 5.54 IUPHAR

External reference:

IDSource
4017794 VUID
N0000146155 NUI
D00247 KEGG_DRUG
1808 RXNORM
C0006376 UMLSCUI
CHEBI:3213 CHEBI
CHEMBL1072 ChEMBL_ID
DB00887 DRUGBANK_ID
D002034 MESH_DESCRIPTOR_UI
2471 PUBCHEM_CID
4837 IUPHAR_LIGAND_ID
2943 INN_ID
0Y2S3XUQ5H UNII
3606 MMSL
4304 MMSL
d00179 MMSL
387498005 SNOMEDCT_US
86647004 SNOMEDCT_US
82U PDB_CHEM_ID
4017794 VANDF
002312 NDDF
0Y2S3XUQ5H INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 0185-0128 TABLET 0.50 mg ORAL ANDA 21 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 0185-0129 TABLET 1 mg ORAL ANDA 21 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 0185-0130 TABLET 2 mg ORAL ANDA 21 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 0615-8614 TABLET 0.50 mg ORAL ANDA 21 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 0615-8615 TABLET 1 mg ORAL ANDA 21 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 0615-8616 TABLET 2 mg ORAL ANDA 21 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 0641-6007 INJECTION 0.25 mg INTRAMUSCULAR ANDA 22 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 0641-6008 INJECTION 0.25 mg INTRAMUSCULAR ANDA 22 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 0641-6161 INJECTION 0.25 mg INTRAMUSCULAR ANDA 22 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 0641-6162 INJECTION 0.25 mg INTRAMUSCULAR ANDA 22 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 0641-6284 INJECTION 0.25 mg INTRAMUSCULAR ANDA 22 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 0641-6285 INJECTION 0.25 mg INTRAMUSCULAR ANDA 22 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 0781-8099 TABLET 0.50 mg ORAL ANDA 21 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 0781-8113 TABLET 1 mg ORAL ANDA 21 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 0781-8160 TABLET 2 mg ORAL ANDA 21 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 0832-0540 TABLET 0.50 mg ORAL ANDA 22 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 0832-0541 TABLET 1 mg ORAL ANDA 22 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 0832-0542 TABLET 2 mg ORAL ANDA 22 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 0904-7016 TABLET 1 mg ORAL ANDA 21 sections
Bumetanide Human Prescription Drug Label 1 16571-677 TABLET 2 mg ORAL ANDA 21 sections
Bumetanide Human Prescription Drug Label 1 16571-678 TABLET 1 mg ORAL ANDA 21 sections
Bumetanide Human Prescription Drug Label 1 16571-679 TABLET 0.50 mg ORAL ANDA 21 sections
bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 23155-900 TABLET 0.50 mg ORAL ANDA 19 sections
bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 23155-901 TABLET 1 mg ORAL ANDA 19 sections
bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 23155-902 TABLET 2 mg ORAL ANDA 19 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 25021-321 INJECTION, SOLUTION 0.25 mg INTRAVENOUS ANDA 23 sections
Bumex HUMAN PRESCRIPTION DRUG LABEL 1 30698-630 TABLET 0.50 mg ORAL NDA 21 sections
Bumex HUMAN PRESCRIPTION DRUG LABEL 1 30698-631 TABLET 1 mg ORAL NDA 21 sections
Bumex HUMAN PRESCRIPTION DRUG LABEL 1 30698-632 TABLET 2 mg ORAL NDA 21 sections
Bumetanide HUMAN PRESCRIPTION DRUG LABEL 1 31722-368 INJECTION 0.25 mg INTRAMUSCULAR ANDA 21 sections