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2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
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Smart API
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L1000
FAQ
Scroll
Substructure SMILES Example:
n1cnccc1
pipemidic acid 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
antibacterials, nalidixic acid derivatives
2184
51940-44-4
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
pipemidic acid
pipeacid
uropimid
Antimicrobial against Gram negative and some Gram positive bacteria. It is protein bound and concentrated in bile and urine and used for gastrointestinal, biliary, and urinary infections.
Molecular weight: 303.32
Formula: C14H17N5O3
CLOGP: -2.23
LIPINSKI: 0
HAC: 8
HDO: 2
TPSA: 98.66
ALOGS: -2.61
ROTB: 3
Drug dosage:
Dose
Unit
Route
0.80
g
O
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
93 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
t_half (Half-life)
3.69 hours
Lombardo F, Berellini G, Obach RS
CL (Clearance)
2.84 mL/min/kg
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
0.88 L/kg
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.70 %
Lombardo F, Berellini G, Obach RS
Showing 1 to 5 of 5 entries
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Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
J01MB04
ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
QUINOLONE ANTIBACTERIALS
Other quinolones
CHEBI has role
CHEBI:36047
antibacterial drugs
CHEBI has role
CHEBI:59517
DNA synthesis inhibitors
MeSH PA
D000900
Anti-Bacterial Agents
MeSH PA
D000890
Anti-Infective Agents
MeSH PA
D000892
Anti-Infective Agents, Urinary
Showing 1 to 6 of 6 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
5.55
acidic
pKa2
8.04
Basic
pKa3
6.43
Basic
Showing 1 to 3 of 3 entries
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
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ID
Source
004201
NDDF
12774
IUPHAR_LIGAND_ID
3694
INN_ID
4831
PUBCHEM_CID
702807004
SNOMEDCT_US
8337
RXNORM
96079005
SNOMEDCT_US
C0031953
UMLSCUI
CHEBI:75250
CHEBI
CHEMBL30116
ChEMBL_ID
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Pharmaceutical products:
None
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pipemidic acid