pazufloxacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibacterials, nalidixic acid derivatives 2070 127045-41-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pazufloxacin mesilate
  • pazufloxacin mesylate
  • pazufloxacin
  • Molecular weight: 318.30
  • Formula: C16H15FN2O4
  • CLOGP: -1.19
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 92.86
  • ALOGS: -2.12
  • ROTB: 2

Drug dosage:

DoseUnitRoute
1 g P

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.68 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.87 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.79 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01MA18 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
QUINOLONE ANTIBACTERIALS
Fluoroquinolones
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000995 Antitubercular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Sepsis due to Streptococcus pneumoniae indication 448421008




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.12 acidic
pKa2 7.56 Basic
pKa3 0.78 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01153 KEGG_DRUG
163680-77-1 SECONDARY_CAS_RN
C0175022 UMLSCUI
CHEBI:31964 CHEBI
CHEMBL240163 ChEMBL_ID
DB11774 DRUGBANK_ID
C078052 MESH_SUPPLEMENTAL_RECORD_UI
65957 PUBCHEM_CID
7247 INN_ID
4CZ1R38NDI UNII

Pharmaceutical products:

None