calcium pantothenate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2055 79-83-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • calcium pantothenate
  • pantothenic acid
  • (+)-Pantothenic acid
  • D-Pantothenic acid
  • Vitamin B5
A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.
  • Molecular weight: 219.24
  • Formula: C9H17NO5
  • CLOGP: -1.49
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 4
  • TPSA: 106.86
  • ALOGS: -0.56
  • ROTB: 6
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1993 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood pressure diastolic increased 52.60 32.78 15 1093 8546 56282413
Blood pressure systolic abnormal 50.63 32.78 15 1093 9762 56281197
Blood pressure diastolic abnormal 48.11 32.78 15 1093 11583 56279376
Mucous stools 45.30 32.78 11 1097 3373 56287586
Ovarian cyst 44.45 32.78 15 1093 14851 56276108

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Fractional exhaled nitric oxide increased 69.57 39.17 12 667 620 31696045
Sensation of foreign body 54.79 39.17 12 667 2159 31694506
Myoglobin blood increased 53.21 39.17 12 667 2465 31694200
Plantar fasciitis 46.77 39.17 10 669 1605 31695060
Brain natriuretic peptide increased 45.14 39.17 12 667 4864 31691801
Secretion discharge 44.99 39.17 12 667 4925 31691740

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ovarian cyst 48.74 29.04 15 1301 11757 70915371
Blood pressure diastolic increased 47.99 29.04 15 1301 12376 70914752
Blood pressure systolic abnormal 47.38 29.04 15 1301 12894 70914234
Blood pressure diastolic abnormal 44.68 29.04 15 1301 15489 70911639
Needle fatigue 30.32 29.04 6 1310 757 70926371
Heart rate decreased 30.03 29.04 17 1299 61998 70865130

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA31 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
ATC D03AX04 DERMATOLOGICALS
PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
CICATRIZANTS
Other cicatrizants
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:74530 curare poisoning antidote
CHEBI has role CHEBI:85234 human blood serum metabolites
CHEBI has role CHEBI:176497 geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ascorbic acid deficiency indication 76169001
Pantothenic acid deficiency indication 238128006
Methemoglobinemia off-label use 38959009 DOID:10783
Primary hyperoxaluria contraindication 17901006 DOID:2977
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Hemochromatosis contraindication 399187006 DOID:2352




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.62 acidic
pKa2 12.98 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
568ET80C3D UNII
4020312 VUID
N0000178898 NUI
D01082 KEGG_DRUG
137-08-6 SECONDARY_CAS_RN
4017627 VANDF
4017672 VANDF
4020312 VANDF
4021034 VANDF
4021902 VANDF
C0006710 UMLSCUI
CHEBI:31345 CHEBI
PAU PDB_CHEM_ID
CHEMBL1901349 ChEMBL_ID
443753 PUBCHEM_CID
CHEMBL1594 ChEMBL_ID
D010205 MESH_DESCRIPTOR_UI
1260 INN_ID
4668 IUPHAR_LIGAND_ID
DB01783 DRUGBANK_ID
1918 RXNORM
5685 MMSL
7440 MMSL
NOCODE MMSL
001056 NDDF
001057 NDDF
126225001 SNOMEDCT_US
66441000 SNOMEDCT_US
86431009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 25 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 7.50 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 7.50 mg ORAL UNAPPROVED DRUG OTHER 14 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 25 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 10 mg ORAL Unapproved drug other 7 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 10 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 10 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 10 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 10 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 10 mg ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 10 mg ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 10 mg ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 10 mg ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 10 mg ORAL Unapproved drug other 7 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 7 mg ORAL unapproved drug other 15 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 7 mg ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 7 mg ORAL unapproved drug other 16 sections
Se-Tan PLUS HUMAN PRESCRIPTION DRUG LABEL 13 13925-118 CAPSULE, GELATIN COATED 10 mg ORAL unapproved drug other 19 sections
Se-Tan PLUS HUMAN PRESCRIPTION DRUG LABEL 13 13925-118 CAPSULE, GELATIN COATED 10 mg ORAL unapproved drug other 19 sections
Quflora FE Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 14 15370-102 LIQUID 1 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 17856-0010 TABLET, COATED 10 mg ORAL Unapproved drug other 8 sections
Centratex HUMAN PRESCRIPTION DRUG LABEL 13 23359-100 CAPSULE 10 mg ORAL unapproved drug other 13 sections
PNV-Select HUMAN PRESCRIPTION DRUG LABEL 18 42192-320 TABLET, FILM COATED 6 mg ORAL unapproved drug other 10 sections
Multi Vitamin and Mineralvitamin HUMAN OTC DRUG LABEL 11 51220-2001 TABLET, CHEWABLE 1.50 mg ORAL unapproved drug other 8 sections
Concept OB HUMAN PRESCRIPTION DRUG LABEL 15 52747-620 CAPSULE 7 mg ORAL unapproved drug other 13 sections
Concept OB HUMAN PRESCRIPTION DRUG LABEL 15 52747-620 CAPSULE 7 mg ORAL unapproved drug other 13 sections
Concept DHA HUMAN PRESCRIPTION DRUG LABEL 15 52747-621 CAPSULE, LIQUID FILLED 5 mg ORAL unapproved drug other 7 sections
Concept DHA HUMAN PRESCRIPTION DRUG LABEL 15 52747-621 CAPSULE, LIQUID FILLED 5 mg ORAL unapproved drug other 7 sections
Integra Plus HUMAN PRESCRIPTION DRUG LABEL 10 52747-712 CAPSULE 5 mg ORAL unapproved drug other 12 sections
Integra Plus HUMAN PRESCRIPTION DRUG LABEL 10 52747-712 CAPSULE 7 mg ORAL unapproved drug other 12 sections