nicotinamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
nicotinic acid or nicotinoyl alcohol derivatives 1906 98-92-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • niacinamide
  • nicotinamide
  • 3-pyridinecarboxamide
An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
  • Molecular weight: 122.13
  • Formula: C6H6N2O
  • CLOGP: -0.21
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 55.98
  • ALOGS: -0.39
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1000 mg/mL Benet LZ, Broccatelli F, Oprea TI

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1778.79 10.42 4410 527521 179316 62777775
Systemic lupus erythematosus 1672.21 10.42 4671 527260 204247 62752844
Glossodynia 1479.07 10.42 4048 527883 174828 62782263
Hand deformity 1206.41 10.42 3495 528436 155962 62801129
Arthropathy 1126.17 10.42 4414 527517 230378 62726713
Abdominal discomfort 1052.41 10.42 5387 526544 315498 62641593
Alopecia 1027.68 10.42 5551 526380 331985 62625106
Wound 999.80 10.42 3325 528606 159938 62797153
Completed suicide 957.39 10.42 68 531863 145605 62811486
Rheumatoid arthritis 896.54 10.42 4353 527578 249466 62707625
Maternal exposure during pregnancy 881.61 10.42 3916 528015 216146 62740945
Synovitis 796.41 10.42 3389 528542 183529 62773562
Toxicity to various agents 762.97 10.42 574 531357 246676 62710415
Anti-cyclic citrullinated peptide antibody positive 756.21 10.42 2417 529514 113795 62843296
Pericarditis 750.05 10.42 2617 529314 128962 62828129
Swelling 745.36 10.42 4390 527541 270988 62686103
Discomfort 743.60 10.42 3074 528857 164300 62792791
Contraindicated product administered 715.20 10.42 3658 528273 213990 62743101
Infusion related reaction 712.03 10.42 3987 527944 241534 62715557
Joint swelling 672.81 10.42 4873 527058 322793 62634298
Pain 606.02 10.42 9122 522809 731506 62225585
Death 537.12 10.42 1494 530437 372887 62584204
Duodenal ulcer perforation 476.42 10.42 1711 530220 85498 62871593
Rheumatoid factor positive 467.06 10.42 1663 530268 82743 62874348
Helicobacter infection 463.02 10.42 1768 530163 91017 62866074
Product use issue 444.65 10.42 3267 528664 217253 62739838
Drug interaction 426.82 10.42 793 531138 228338 62728753
Intentional overdose 418.99 10.42 61 531870 74091 62883000
Hepatic enzyme increased 411.56 10.42 3004 528927 199324 62757767
Drug abuse 384.43 10.42 71 531860 72447 62884644
Arthralgia 382.58 10.42 6797 525134 562913 62394178
Psoriatic arthropathy 349.50 10.42 1607 530324 89913 62867178
Musculoskeletal stiffness 340.47 10.42 2679 529252 181939 62775152
Therapeutic product effect decreased 326.90 10.42 2749 529182 190438 62766653
Febrile neutropenia 311.79 10.42 319 531612 118130 62838961
Drug intolerance 310.54 10.42 3949 527982 304712 62652379
Suicide attempt 278.63 10.42 82 531849 60836 62896255
Exposure during pregnancy 277.86 10.42 2241 529690 153306 62803785
Treatment failure 270.10 10.42 2701 529230 196342 62760749
Depressed level of consciousness 252.11 10.42 102 531829 61976 62895115
Acute kidney injury 250.68 10.42 1244 530687 262171 62694920
Hip arthroplasty 247.58 10.42 920 531011 46726 62910365
Cardiac arrest 243.80 10.42 249 531682 92296 62864795
Knee arthroplasty 241.39 10.42 997 530934 53209 62903882
Overdose 241.08 10.42 369 531562 114709 62842382
Hypersensitivity 233.73 10.42 3595 528336 289090 62668001
Malignant neoplasm progression 219.69 10.42 218 531713 81903 62875188
Rheumatic fever 209.61 10.42 815 531116 42296 62914795
Impaired healing 205.06 10.42 1517 530414 101025 62856066
Disease progression 204.37 10.42 453 531478 122305 62834786
Nasopharyngitis 196.03 10.42 3105 528826 251152 62705939
Neutropenia 187.50 10.42 791 531140 174214 62782877
Swollen joint count increased 183.00 10.42 691 531240 35363 62921728
Sedation 174.28 10.42 54 531877 38755 62918336
Blister 170.37 10.42 1750 530181 128064 62829027
Folliculitis 170.02 10.42 1090 530841 69227 62887864
Electrocardiogram QT prolonged 169.86 10.42 149 531782 59381 62897710
Hyponatraemia 166.44 10.42 438 531493 111462 62845629
Red blood cell sedimentation rate abnormal 165.29 10.42 450 531481 19332 62937759
Muscle injury 164.87 10.42 1024 530907 64321 62892770
Bradycardia 163.97 10.42 224 531707 73003 62884088
Constipation 163.63 10.42 1157 530774 223786 62733305
Lactic acidosis 161.95 10.42 59 531872 38228 62918863
Fatigue 152.20 10.42 8983 522948 879045 62078046
Hypotension 149.27 10.42 1511 530420 271093 62685998
Sleep disorder due to general medical condition, insomnia type 145.61 10.42 840 531091 51377 62905714
Cardiac failure 145.05 10.42 333 531598 88809 62868282
Nausea 143.01 10.42 5785 526146 848686 62108405
Sickle cell anaemia with crisis 140.45 10.42 210 531721 5793 62951298
Rash 140.44 10.42 5888 526043 554983 62402108
Drug reaction with eosinophilia and systemic symptoms 136.72 10.42 56 531875 33780 62923311
Irritable bowel syndrome 135.62 10.42 1166 530765 81246 62875845
Agitation 135.60 10.42 181 531750 59576 62897515
Somnolence 132.89 10.42 913 531018 177772 62779319
Renal failure 132.73 10.42 521 531410 117131 62839960
Hyperhidrosis 132.48 10.42 461 531470 107375 62849716
Rhabdomyolysis 131.55 10.42 105 531826 43846 62913245
Diarrhoea 131.23 10.42 4790 527141 710576 62246515
Respiratory arrest 130.34 10.42 55 531876 32590 62924501
C-reactive protein abnormal 128.83 10.42 742 531189 45354 62911737
Drug hypersensitivity 128.07 10.42 1832 530099 308855 62648236
Lower respiratory tract infection 122.36 10.42 1668 530263 130639 62826452
Neoplasm progression 122.21 10.42 77 531854 36351 62920740
Asthenia 122.09 10.42 2372 529559 381232 62575859
Sopor 121.16 10.42 20 531911 22144 62934947
Tremor 120.81 10.42 633 531298 131606 62825485
Blood cholesterol increased 120.66 10.42 1262 530669 92770 62864321
Osteoarthritis 116.92 10.42 1268 530663 94075 62863016
Intentional self-injury 116.67 10.42 35 531896 25652 62931439
Anxiety 114.44 10.42 1217 530714 216324 62740767
Vomiting 113.13 10.42 3701 528230 555916 62401175
Dyspnoea 112.37 10.42 4468 527463 656845 62300246
Tachycardia 112.23 10.42 558 531373 117598 62839493
Cardio-respiratory arrest 109.27 10.42 210 531721 59749 62897342
Thrombocytopenia 107.65 10.42 782 531149 150375 62806716
Serotonin syndrome 107.22 10.42 53 531878 28629 62928462
Syncope 103.83 10.42 568 531363 116817 62840274
Liver injury 103.65 10.42 864 531067 59656 62897435
Arthritis 102.95 10.42 1451 530480 114470 62842621
Type 2 diabetes mellitus 102.13 10.42 898 531033 62970 62894121
Pregnancy 100.37 10.42 589 531342 36247 62920844
Condition aggravated 100.11 10.42 4221 527710 397996 62559095
Hypoglycaemia 99.63 10.42 222 531709 59843 62897248
Cognitive disorder 98.68 10.42 199 531732 55616 62901475
Psoriasis 96.44 10.42 1134 530797 85823 62871268
Fibromyalgia 94.68 10.42 1061 530870 79359 62877732
Metabolic acidosis 92.92 10.42 146 531785 44923 62912168
No adverse event 92.33 10.42 127 531804 41278 62915813
Hepatic failure 90.44 10.42 99 531832 35557 62921534
Renal impairment 89.31 10.42 408 531523 87947 62869144
Intentional product misuse 87.12 10.42 243 531688 60674 62896417
Coma 86.77 10.42 264 531667 64100 62892991
Anaemia 86.52 10.42 1837 530094 291593 62665498
Intentional product use issue 85.27 10.42 1526 530405 126366 62830725
Peripheral swelling 85.05 10.42 2870 529061 263072 62694019
Drug resistance 84.79 10.42 43 531888 22890 62934201
Drug ineffective 84.70 10.42 9988 521943 1034777 61922314
Live birth 84.06 10.42 431 531500 25199 62931892
Sedation complication 83.82 10.42 9 531922 13813 62943278
Drug dependence 81.78 10.42 52 531879 24431 62932660
Respiratory failure 81.47 10.42 509 531422 101349 62855742
Ill-defined disorder 81.08 10.42 1044 530887 80711 62876380
Abortion spontaneous 80.93 10.42 674 531257 46521 62910570
Hepatic function abnormal 80.75 10.42 116 531815 37026 62920065
Multiple organ dysfunction syndrome 80.70 10.42 227 531704 56525 62900566
Orthostatic hypotension 80.54 10.42 111 531820 36049 62921042
Hyperglycaemia 80.40 10.42 142 531789 41725 62915366
Multiple sclerosis relapse 79.73 10.42 180 531751 48298 62908793
Contusion 79.72 10.42 1730 530201 148314 62808777
Joint effusion 79.26 10.42 318 531613 16742 62940349
Asthma 78.74 10.42 686 531245 126875 62830216
Seizure 78.49 10.42 721 531210 131913 62825178
Altered state of consciousness 78.40 10.42 58 531873 25172 62931919
Neuropathy peripheral 77.60 10.42 595 531336 113072 62844019
Myalgia 76.90 10.42 820 531111 145709 62811382
Angioedema 76.54 10.42 181 531750 47784 62909307
Dizziness 75.80 10.42 2891 529040 427034 62530057
Drug withdrawal syndrome 74.08 10.42 71 531860 27123 62929968
Blood pressure diastolic abnormal 74.02 10.42 279 531652 14263 62942828
Blood pressure fluctuation 73.92 10.42 651 531280 45666 62911425
Hallucination 73.78 10.42 225 531706 54592 62902499
Blood pressure systolic abnormal 73.33 10.42 263 531668 13123 62943968
Creatinine renal clearance decreased 70.90 10.42 24 531907 16284 62940807
Drug ineffective for unapproved indication 70.55 10.42 110 531821 33953 62923138
Hypoxia 70.49 10.42 260 531671 59532 62897559
Sinusitis 69.92 10.42 2436 529495 224217 62732874
Hyperkalaemia 69.77 10.42 227 531704 53976 62903115
Encephalopathy 69.72 10.42 136 531795 38484 62918607
Product quality issue 69.46 10.42 121 531810 35744 62921347
Cytomegalovirus infection 69.30 10.42 45 531886 20907 62936184
Device expulsion 69.30 10.42 116 531815 34806 62922285
Blood glucose increased 68.82 10.42 415 531516 83341 62873750
Dehydration 68.60 10.42 1030 530901 172324 62784767
Hepatocellular injury 68.37 10.42 77 531854 27304 62929787
Foot deformity 68.06 10.42 433 531498 27420 62929671
Red blood cell sedimentation rate increased 68.04 10.42 614 531317 43368 62913723
Neutrophil count decreased 67.34 10.42 244 531687 56162 62900929
Disability assessment scale score increased 67.09 10.42 107 531824 3126 62953965
Metastases to bone 67.04 10.42 47 531884 20972 62936119
Anaphylactic reaction 66.93 10.42 305 531626 65795 62891296
Cholestasis 66.93 10.42 89 531842 29345 62927746
Palmar-plantar erythrodysaesthesia syndrome 66.38 10.42 57 531874 22958 62934133
Cardiac failure congestive 66.36 10.42 477 531454 91956 62865135
Balance disorder 65.90 10.42 425 531506 83997 62873094
Chest discomfort 65.83 10.42 596 531335 109373 62847718
Leukopenia 64.01 10.42 382 531549 76908 62880183
Vision blurred 63.77 10.42 479 531452 91445 62865646
Ejection fraction decreased 63.57 10.42 56 531875 22276 62934815
Basal cell carcinoma 62.84 10.42 426 531505 27565 62929526
COVID-19 60.12 10.42 631 531300 112472 62844619
Poisoning 59.85 10.42 20 531911 13680 62943411
Osteonecrosis of jaw 59.74 10.42 128 531803 34995 62922096
Product use in unapproved indication 59.71 10.42 1098 530833 177982 62779109
Shock 59.66 10.42 65 531866 23398 62933693
Myocardial infarction 59.53 10.42 542 531389 99351 62857740
Hypokalaemia 59.38 10.42 569 531362 103235 62853856
Grip strength decreased 59.19 10.42 354 531577 21933 62935158
Diabetic ketoacidosis 58.87 10.42 51 531880 20454 62936637
Injection site erythema 58.84 10.42 1002 530929 82172 62874919
Feeling abnormal 58.60 10.42 882 531049 147510 62809581
Anaphylactic shock 58.42 10.42 67 531864 23566 62933525
Pulmonary fibrosis 58.18 10.42 549 531382 39260 62917831
Stomatitis 57.47 10.42 1546 530385 137179 62819912
Suicidal ideation 57.42 10.42 298 531633 62123 62894968
Cytokine release syndrome 57.32 10.42 24 531907 14290 62942801
Infection 57.32 10.42 2407 529524 226766 62730325
Insomnia 57.30 10.42 1369 530562 213883 62743208
Gamma-glutamyltransferase increased 57.07 10.42 125 531806 33906 62923185
Blood pressure systolic increased 56.99 10.42 628 531303 46769 62910322
Loss of consciousness 56.85 10.42 674 531257 117447 62839644
Blood creatine phosphokinase increased 56.83 10.42 105 531826 30325 62926766
Respiratory depression 56.55 10.42 22 531909 13693 62943398
Osteoporosis 56.33 10.42 731 531200 56607 62900484
Juvenile idiopathic arthritis 55.65 10.42 100 531831 3226 62953865
Disturbance in attention 55.60 10.42 151 531780 38038 62919053
Restlessness 55.56 10.42 101 531830 29352 62927739
Weight increased 55.40 10.42 2694 529237 258098 62698993
Blood calcium decreased 55.18 10.42 85 531846 26366 62930725
White blood cell count decreased 54.85 10.42 827 531104 138277 62818814
Mydriasis 54.83 10.42 16 531915 11940 62945151
Bone erosion 54.02 10.42 292 531639 17425 62939666
Disorientation 53.04 10.42 162 531769 39290 62917801
Drug level increased 52.46 10.42 68 531863 22668 62934423
Ventricular tachycardia 52.31 10.42 54 531877 19925 62937166
Wrong technique in product usage process 52.21 10.42 307 531624 62033 62895058
Joint laxity 51.75 10.42 82 531849 2382 62954709
Joint range of motion decreased 51.34 10.42 455 531476 31973 62925118
Platelet count decreased 50.50 10.42 677 531254 115445 62841646
Extrapyramidal disorder 50.49 10.42 24 531907 13260 62943831
Disseminated intravascular coagulation 50.44 10.42 51 531880 19000 62938091
Blood pressure decreased 50.41 10.42 328 531603 64694 62892397
Metastases to liver 50.24 10.42 75 531856 23564 62933527
Dysphagia 50.06 10.42 487 531444 88098 62868993
Torsade de pointes 49.41 10.42 25 531906 13326 62943765
Inflammation 49.38 10.42 966 530965 81307 62875784
Joint destruction 49.04 10.42 139 531792 6113 62950978
Mental status changes 48.80 10.42 169 531762 39430 62917661
Caesarean section 48.78 10.42 276 531655 16756 62940335
Acute hepatic failure 48.59 10.42 49 531882 18278 62938813
Drug tolerance decreased 47.99 10.42 280 531651 17193 62939898
Loss of personal independence in daily activities 47.95 10.42 1110 530821 96180 62860911
Cerebral haemorrhage 47.42 10.42 118 531813 30611 62926480
Respiratory disorder 47.35 10.42 168 531763 38914 62918177
Speech disorder 46.38 10.42 179 531752 40450 62916641
Palpitations 46.34 10.42 665 531266 112105 62844986
C-reactive protein increased 46.20 10.42 1079 530852 93628 62863463
Ascites 46.13 10.42 180 531751 40548 62916543
Neurotoxicity 45.53 10.42 45 531886 16945 62940146
Abnormal behaviour 45.52 10.42 68 531863 21358 62935733
Blood alkaline phosphatase increased 45.47 10.42 195 531736 42772 62914319
Injection site reaction 45.46 10.42 716 531215 57808 62899283
Sepsis 45.24 10.42 958 530973 152165 62804926
Hypothermia 45.15 10.42 29 531902 13552 62943539
Emotional distress 44.95 10.42 132 531799 32417 62924674
Urticaria 44.80 10.42 1052 530879 164750 62792341
Accidental exposure to product 44.05 10.42 103 531828 27302 62929789
Polyarthritis 43.88 10.42 185 531746 9961 62947130
Injection site pruritus 43.82 10.42 574 531357 44542 62912549
Inappropriate antidiuretic hormone secretion 43.74 10.42 39 531892 15423 62941668
Muscle spasticity 43.60 10.42 72 531859 21722 62935369
Pulmonary embolism 43.53 10.42 701 531230 115983 62841108
Dysarthria 43.28 10.42 197 531734 42514 62914577
Unresponsive to stimuli 43.25 10.42 142 531789 33674 62923417
Posterior reversible encephalopathy syndrome 43.06 10.42 49 531882 17296 62939795
Schizophrenia 42.66 10.42 15 531916 9937 62947154
Akathisia 42.38 10.42 12 531919 9134 62947957
Myelosuppression 42.33 10.42 84 531847 23619 62933472
Flushing 41.92 10.42 414 531517 74673 62882418
Chronic kidney disease 41.60 10.42 217 531714 45181 62911910
Blood bilirubin increased 41.52 10.42 165 531766 36975 62920116
Depression 41.31 10.42 1292 530639 195200 62761891
Neuroleptic malignant syndrome 41.11 10.42 25 531906 12031 62945060
Disability 41.04 10.42 279 531652 18068 62939023
Withdrawal syndrome 41.01 10.42 65 531866 19932 62937159
Vertigo 40.61 10.42 314 531617 59573 62897518
Fluid retention 40.45 10.42 313 531618 59373 62897718
Blood pressure diastolic decreased 40.39 10.42 327 531604 22379 62934712
Device difficult to use 40.30 10.42 29 531902 12767 62944324
Psychotic disorder 40.25 10.42 98 531833 25614 62931477
Hepatotoxicity 39.87 10.42 167 531764 36874 62920217
Polyneuropathy 39.84 10.42 38 531893 14551 62942540
Rheumatoid nodule 39.65 10.42 263 531668 16892 62940199
Parkinsonism 39.46 10.42 19 531912 10420 62946671
Gestational diabetes 39.40 10.42 157 531774 8239 62948852
Respiratory distress 39.12 10.42 149 531782 33802 62923289
Eosinophilia 38.64 10.42 83 531848 22673 62934418
Neck deformity 38.37 10.42 66 531865 2055 62955036
Toxic skin eruption 38.28 10.42 31 531900 12854 62944237
Bone pain 38.23 10.42 284 531647 54357 62902734
Premature labour 38.07 10.42 206 531725 12298 62944793
Accidental overdose 37.96 10.42 87 531844 23222 62933869
Disease recurrence 37.75 10.42 115 531816 27915 62929176
Foetal exposure during pregnancy 37.74 10.42 422 531509 31540 62925551
Dystonia 37.73 10.42 36 531895 13783 62943308
Stress cardiomyopathy 37.59 10.42 16 531915 9434 62947657
Blood creatinine increased 37.51 10.42 514 531417 87330 62869761
Arrhythmia 37.42 10.42 178 531753 37962 62919129
Thrombotic microangiopathy 37.28 10.42 21 531910 10540 62946551
Tuberculosis 37.09 10.42 189 531742 11022 62946069
Depressed mood 36.89 10.42 192 531739 39999 62917092
Agranulocytosis 36.87 10.42 99 531832 25035 62932056
Adverse event 36.82 10.42 782 531149 66777 62890314
Acute generalised exanthematous pustulosis 36.49 10.42 24 531907 11075 62946016
Multiple fractures 36.39 10.42 156 531775 8462 62948629
Hospitalisation 36.27 10.42 498 531433 84583 62872508
Hypomania 36.23 10.42 5 531926 6325 62950766
Diabetes mellitus inadequate control 36.19 10.42 44 531887 15082 62942009
Product administration error 36.14 10.42 84 531847 22313 62934778
Pain in jaw 35.99 10.42 215 531716 43281 62913810
Haemorrhage 35.95 10.42 332 531599 60690 62896401
Ventricular fibrillation 35.95 10.42 28 531903 11839 62945252
Joint stiffness 35.90 10.42 521 531410 41348 62915743
Dyskinesia 35.88 10.42 142 531789 31860 62925231
Exposure to toxic agent 35.57 10.42 3 531928 5584 62951507
Haematotoxicity 35.54 10.42 17 531914 9359 62947732
Decreased appetite 35.23 10.42 1731 530200 249321 62707770
Cerebrovascular accident 34.84 10.42 666 531265 107358 62849733
Pancreatitis acute 34.80 10.42 114 531817 27052 62930039
Aspartate aminotransferase increased 34.79 10.42 539 531392 89738 62867353
Metastases to central nervous system 34.79 10.42 35 531896 13070 62944021
Alanine aminotransferase increased 34.64 10.42 636 531295 103134 62853957
Nodule 34.31 10.42 297 531634 20729 62936362
Gastrointestinal haemorrhage 34.30 10.42 476 531455 80700 62876391
Gastrointestinal disorder 34.28 10.42 1385 530546 129854 62827237
Face oedema 34.09 10.42 74 531857 20138 62936953
Second primary malignancy 34.06 10.42 12 531919 7941 62949150
Pulmonary oedema 33.88 10.42 295 531636 54578 62902513
Miosis 33.43 10.42 10 531921 7343 62949748
Brain oedema 33.22 10.42 42 531889 14153 62942938
Transplant rejection 33.21 10.42 25 531906 10755 62946336
Hemiparesis 33.19 10.42 93 531838 23189 62933902
Maternal drugs affecting foetus 33.10 10.42 108 531823 5134 62951957
Dysgeusia 33.05 10.42 242 531689 46468 62910623
Mobility decreased 32.90 10.42 1284 530647 119875 62837216
Bronchospasm 32.82 10.42 59 531872 17221 62939870
Laryngitis 32.74 10.42 249 531682 16718 62940373
Hypomagnesaemia 32.55 10.42 127 531804 28610 62928481
Coagulopathy 32.40 10.42 78 531853 20466 62936625
Mania 31.73 10.42 34 531897 12333 62944758
Status epilepticus 31.73 10.42 49 531882 15184 62941907
Lymphocyte count decreased 31.60 10.42 138 531793 30119 62926972
Jaundice 31.41 10.42 132 531799 29119 62927972
Tenderness 31.32 10.42 308 531623 22270 62934821
Atrioventricular block complete 31.21 10.42 15 531916 8236 62948855
Ventricular septal defect 31.14 10.42 94 531837 4284 62952807
Irritability 31.04 10.42 148 531783 31546 62925545
Nightmare 30.96 10.42 72 531859 19122 62937969
Pulmonary arterial hypertension 30.85 10.42 92 531839 22485 62934606
Melaena 30.80 10.42 140 531791 30225 62926866
Musculoskeletal pain 30.75 10.42 1001 530930 91276 62865815
Forced expiratory volume decreased 30.74 10.42 3 531928 4965 62952126
Panic attack 30.52 10.42 91 531840 22240 62934851
Atrial fibrillation 30.40 10.42 744 531187 115892 62841199
Injection site swelling 30.40 10.42 564 531367 47008 62910083
Joint dislocation 30.38 10.42 265 531666 18535 62938556
Pleural effusion 30.26 10.42 574 531357 92636 62864455
Dyspnoea exertional 30.20 10.42 341 531590 59961 62897130
Maternal exposure before pregnancy 30.10 10.42 135 531796 7468 62949623
Proteinuria 29.94 10.42 73 531858 19072 62938019
Device use error 29.76 10.42 6 531925 5755 62951336
Enthesopathy 29.75 10.42 147 531784 8467 62948624
Substance abuse 29.49 10.42 3 531928 4804 62952287
Heart rate decreased 29.41 10.42 541 531390 45019 62912072
International normalised ratio increased 29.37 10.42 248 531683 46177 62910914
Obstructive airways disorder 29.27 10.42 83 531848 20616 62936475
Asphyxia 28.85 10.42 8 531923 6173 62950918
Tumour lysis syndrome 28.80 10.42 20 531911 8970 62948121
Cytopenia 28.55 10.42 33 531898 11568 62945523
Myoclonus 28.54 10.42 56 531875 15812 62941279
Latent tuberculosis 28.49 10.42 66 531865 2561 62954530
Ankylosing spondylitis 28.22 10.42 167 531764 10307 62946784
Pyrexia 28.13 10.42 3482 528449 466996 62490095
Prescribed underdose 28.11 10.42 376 531555 29313 62927778
General physical health deterioration 28.09 10.42 2004 529927 199398 62757693
Hyperlipidaemia 28.03 10.42 78 531853 19493 62937598
Wheelchair user 27.94 10.42 116 531815 6203 62950888
Pain in extremity 27.90 10.42 3179 528752 328307 62628784
Aggression 27.81 10.42 102 531829 23396 62933695
Ischaemic stroke 27.67 10.42 69 531862 17888 62939203
Sinus tachycardia 27.64 10.42 107 531824 24161 62932930
Cardiogenic shock 27.56 10.42 69 531862 17863 62939228
Metastases to lung 27.54 10.42 40 531891 12710 62944381
Haemophagocytic lymphohistiocytosis 27.51 10.42 29 531902 10598 62946493
Blood pressure diastolic increased 27.22 10.42 160 531771 9850 62947241
Erythema multiforme 27.18 10.42 27 531904 10142 62946949
Stevens-Johnson syndrome 27.16 10.42 112 531819 24838 62932253
Localised infection 27.13 10.42 379 531552 29831 62927260
Chest pain 27.07 10.42 1506 530425 214453 62742638
Lupus-like syndrome 27.05 10.42 220 531711 15075 62942016
Cerebral infarction 26.80 10.42 106 531825 23787 62933304
Device related infection 26.73 10.42 103 531828 23289 62933802
Limb deformity 26.68 10.42 84 531847 3918 62953173
Back pain 26.53 10.42 1880 530051 262265 62694826
Product dose omission issue 26.51 10.42 1650 530281 232663 62724428
Aphasia 26.32 10.42 165 531766 32835 62924256
Haemorrhage intracranial 26.23 10.42 45 531886 13374 62943717
Obesity 26.19 10.42 374 531557 29578 62927513
Small for dates baby 26.18 10.42 80 531851 3671 62953420
Graft versus host disease 26.04 10.42 12 531919 6751 62950340
Peripheral venous disease 25.98 10.42 220 531711 15257 62941834
Bradyphrenia 25.93 10.42 13 531918 6967 62950124
Angina pectoris 25.78 10.42 147 531784 29931 62927160
Acute respiratory failure 25.70 10.42 176 531755 34309 62922782
Rash maculo-papular 25.69 10.42 159 531772 31737 62925354
Paralysis 25.65 10.42 27 531904 9873 62947218
Facet joint syndrome 25.63 10.42 182 531749 11956 62945135
Off label use 25.63 10.42 5124 526807 669338 62287753
Acute myeloid leukaemia 25.56 10.42 67 531864 17080 62940011
Tachypnoea 25.49 10.42 68 531863 17234 62939857
Urinary retention 25.48 10.42 149 531782 30152 62926939
Rhinitis allergic 25.12 10.42 37 531894 11690 62945401
Temperature regulation disorder 25.01 10.42 10 531921 6122 62950969
Dry skin 24.96 10.42 331 531600 56556 62900535
Muscle twitching 24.87 10.42 83 531848 19585 62937506
Malignant mediastinal neoplasm 24.87 10.42 44 531887 1402 62955689
Pre-eclampsia 24.85 10.42 146 531785 8987 62948104
Injection site bruising 24.77 10.42 491 531440 41419 62915672
Premature rupture of membranes 24.75 10.42 95 531836 4898 62952193
Tenosynovitis 24.71 10.42 199 531732 13596 62943495
Smear cervix abnormal 24.59 10.42 67 531864 2879 62954212
Lethargy 24.53 10.42 326 531605 55681 62901410
Deep vein thrombosis 24.52 10.42 525 531406 83275 62873816
Injection site pain 24.48 10.42 1326 530605 128474 62828617
Paradoxical drug reaction 24.44 10.42 3 531928 4149 62952942
Haemoptysis 24.29 10.42 141 531790 28585 62928506
Femur fracture 24.28 10.42 488 531443 41268 62915823
Acute graft versus host disease 24.19 10.42 4 531927 4424 62952667
Hallucination, auditory 24.17 10.42 44 531887 12780 62944311
Bronchopulmonary aspergillosis 24.16 10.42 22 531909 8613 62948478
Clostridium difficile colitis 23.87 10.42 90 531841 20479 62936612
Tenosynovitis stenosans 23.71 10.42 72 531859 3292 62953799
Diabetes mellitus 23.66 10.42 327 531604 55483 62901608
Acidosis 23.52 10.42 36 531895 11197 62945894
Neck mass 23.45 10.42 75 531856 3528 62953563
Haematoma 23.40 10.42 183 531748 34637 62922454
Complication of device removal 23.36 10.42 7 531924 5135 62951956
Muscle spasms 23.20 10.42 1070 530861 155080 62802011
Fear 23.20 10.42 62 531869 15704 62941387
Sleep apnoea syndrome 23.06 10.42 146 531785 28987 62928104
Retinitis 23.03 10.42 108 531823 6088 62951003
Exostosis 23.02 10.42 240 531691 17622 62939469
Muscle rigidity 23.00 10.42 38 531893 11462 62945629
Red blood cell sedimentation rate 22.96 10.42 91 531840 4763 62952328
Synovial cyst 22.95 10.42 158 531773 10275 62946816
Delirium 22.94 10.42 292 531639 50249 62906842
Personality disorder 22.86 10.42 10 531921 5801 62951290
Dislocation of vertebra 22.83 10.42 137 531794 8498 62948593
Anuria 22.82 10.42 44 531887 12507 62944584
Myocarditis 22.69 10.42 32 531899 10293 62946798
Rash erythematous 22.64 10.42 237 531694 42273 62914818
Mental disorder 22.58 10.42 126 531805 25793 62931298
Bone marrow failure 22.57 10.42 148 531783 29142 62927949
Febrile bone marrow aplasia 22.55 10.42 17 531914 7308 62949783
Breast cancer stage I 22.51 10.42 15 531916 6874 62950217
Rotator cuff repair 22.47 10.42 53 531878 2081 62955010
Lip dry 22.43 10.42 213 531718 15257 62941834
Purpura 22.42 10.42 38 531893 11347 62945744
Wound infection 22.32 10.42 276 531655 21134 62935957
Crying 22.28 10.42 110 531821 23233 62933858
Skin exfoliation 22.27 10.42 242 531689 42860 62914231
Tardive dyskinesia 22.23 10.42 23 531908 8479 62948612
Colitis 22.16 10.42 280 531651 48248 62908843
Infusion site pain 22.16 10.42 70 531861 16799 62940292
Hallucination, visual 22.04 10.42 85 531846 19213 62937878
Affective disorder 22.02 10.42 12 531919 6134 62950957
Dysmorphism 22.02 10.42 55 531876 2241 62954850
Lip swelling 21.94 10.42 161 531770 30902 62926189
Labelled drug-drug interaction medication error 21.82 10.42 50 531881 13349 62943742
Multiple-drug resistance 21.80 10.42 8 531923 5162 62951929
Skin papilloma 21.80 10.42 91 531840 4878 62952213
Infective pulmonary exacerbation of cystic fibrosis 21.79 10.42 25 531906 8792 62948299
Maternal exposure timing unspecified 21.74 10.42 117 531814 6970 62950121
Anti-cyclic citrullinated peptide antibody 21.71 10.42 113 531818 6645 62950446
Sexual dysfunction 21.58 10.42 5 531926 4354 62952737
Complication of device insertion 21.49 10.42 19 531912 7545 62949546
Hypothyroidism 21.37 10.42 241 531690 42391 62914700
Nasal polyps 21.33 10.42 12 531919 6027 62951064
Placental disorder 21.17 10.42 42 531889 1462 62955629
Skin ulcer 21.16 10.42 491 531440 42554 62914537
Circulatory collapse 21.16 10.42 103 531828 21835 62935256
Injection site rash 21.15 10.42 246 531685 18563 62938528
Gastroenteritis viral 21.15 10.42 297 531634 23403 62933688
Memory impairment 21.06 10.42 689 531242 103569 62853522
Pulmonary hypertension 21.00 10.42 204 531727 36919 62920172
Malignant melanoma 20.99 10.42 165 531766 11191 62945900
Synovial fluid analysis 20.98 10.42 56 531875 2377 62954714
Pathogen resistance 20.81 10.42 14 531917 6384 62950707
Cough 20.79 10.42 2141 529790 290602 62666489
Swollen tongue 20.64 10.42 189 531742 34611 62922480
Body height below normal 20.63 10.42 52 531879 2131 62954960
Psychomotor hyperactivity 20.62 10.42 36 531895 10627 62946464
Dermatitis atopic 20.52 10.42 31 531900 9693 62947398
Leukocytosis 20.52 10.42 130 531801 25805 62931286
Prescribed overdose 20.48 10.42 401 531530 33752 62923339
Glycosylated haemoglobin increased 20.41 10.42 46 531885 12352 62944739
Therapeutic response decreased 20.38 10.42 667 531264 60858 62896233
Hyperprolactinaemia 20.28 10.42 4 531927 3896 62953195
Nervousness 20.27 10.42 164 531767 30815 62926276
Immune reconstitution inflammatory syndrome 20.21 10.42 13 531918 6071 62951020
Abdominal pain 20.20 10.42 2151 529780 291305 62665786
Acute respiratory distress syndrome 20.18 10.42 115 531816 23419 62933672
Developmental hip dysplasia 20.14 10.42 39 531892 1333 62955758
Genital haemorrhage 20.14 10.42 19 531912 7313 62949778
Aspergillus infection 19.94 10.42 23 531908 8070 62949021
Body temperature decreased 19.93 10.42 259 531672 20060 62937031
Pancreatitis 19.89 10.42 290 531641 48765 62908326
Adjustment disorder with depressed mood 19.83 10.42 150 531781 10054 62947037
Ketoacidosis 19.82 10.42 6 531925 4372 62952719
Cardiomyopathy 19.73 10.42 78 531853 17506 62939585
Malaise 19.72 10.42 3122 528809 412832 62544259
Cyanosis 19.72 10.42 74 531857 16861 62940230
Cardiotoxicity 19.71 10.42 25 531906 8413 62948678
Anhedonia 19.50 10.42 39 531892 10935 62946156
Loose body in joint 19.42 10.42 37 531894 1249 62955842
Hemiplegia 19.41 10.42 30 531901 9293 62947798
Sinus bradycardia 19.38 10.42 60 531871 14491 62942600
Hepatitis acute 19.32 10.42 29 531902 9091 62948000
Deep vein thrombosis postoperative 19.29 10.42 162 531769 11207 62945884
Pericardial effusion 19.27 10.42 160 531771 29898 62927193
Arthritis infective 19.23 10.42 106 531825 6372 62950719
Product prescribing error 19.18 10.42 135 531796 26154 62930937
Coronary artery disease 19.13 10.42 176 531755 32201 62924890
Rebound effect 19.09 10.42 7 531924 4519 62952572
Toxic epidermal necrolysis 19.02 10.42 129 531802 25205 62931886
Spinal stenosis 18.98 10.42 200 531731 14725 62942366
Pseudomonas infection 18.95 10.42 41 531890 11172 62945919
Vascular device infection 18.88 10.42 20 531911 7292 62949799
Paranoia 18.69 10.42 44 531887 11635 62945456
Bursitis 18.67 10.42 424 531507 36617 62920474
Blood potassium decreased 18.63 10.42 244 531687 41782 62915309
Synovial disorder 18.58 10.42 48 531883 1997 62955094
Atrioventricular block 18.55 10.42 22 531909 7625 62949466
Cardiac failure acute 18.55 10.42 32 531899 9491 62947600
Hyperthyroidism 18.50 10.42 62 531869 14611 62942480
Pulmonary congestion 18.46 10.42 79 531852 17339 62939752
Foetal anticonvulsant syndrome 18.39 10.42 24 531907 581 62956510
Hypophosphataemia 18.32 10.42 43 531888 11383 62945708
Tubulointerstitial nephritis 18.31 10.42 95 531836 19808 62937283
Abdominal distension 18.31 10.42 569 531362 86046 62871045
Lymphopenia 18.29 10.42 85 531846 18242 62938849
Acute chest syndrome 18.19 10.42 28 531903 793 62956298
Fall 18.13 10.42 2949 528982 389385 62567706
Rheumatoid lung 18.09 10.42 72 531859 3776 62953315
Clear cell renal cell carcinoma 18 10.42 39 531892 1446 62955645
Therapy partial responder 17.99 10.42 39 531892 10619 62946472
Acute myocardial infarction 17.97 10.42 177 531754 31947 62925144
Lymphoedema 17.96 10.42 45 531886 11647 62945444
Hallucinations, mixed 17.93 10.42 9 531922 4820 62952271
Eating disorder 17.93 10.42 90 531841 18926 62938165
Delusion 17.88 10.42 47 531884 11970 62945121
Schizoaffective disorder 17.81 10.42 4 531927 3558 62953533
Subdural haematoma 17.75 10.42 61 531870 14267 62942824
Shock haemorrhagic 17.72 10.42 35 531896 9860 62947231
Bradypnoea 17.72 10.42 4 531927 3546 62953545
Atrial septal defect 17.66 10.42 109 531822 6829 62950262
Epstein-Barr virus infection 17.64 10.42 25 531906 8025 62949066
Blood glucose decreased 17.63 10.42 103 531828 20849 62936242
Graft versus host disease in gastrointestinal tract 17.55 10.42 3 531928 3238 62953853
Antinuclear antibody positive 17.51 10.42 121 531810 7878 62949213
Hepatic cytolysis 17.50 10.42 68 531863 15339 62941752
Hypervolaemia 17.43 10.42 153 531778 28260 62928831
Systemic inflammatory response syndrome 17.36 10.42 13 531918 5608 62951483
Generalised oedema 17.22 10.42 71 531860 15747 62941344
Renal disorder 17.09 10.42 185 531746 32789 62924302
Skin cancer 17.03 10.42 159 531772 11336 62945755
Chills 17.02 10.42 776 531155 112602 62844489
Eosinophil count increased 16.83 10.42 42 531889 10886 62946205
Body temperature increased 16.83 10.42 215 531716 36977 62920114
Jaundice cholestatic 16.80 10.42 22 531909 7302 62949789
Complication associated with device 16.79 10.42 79 531852 16899 62940192
Hepatitis B reactivation 16.77 10.42 3 531928 3134 62953957
Hypophagia 16.76 10.42 174 531757 31085 62926006
Colitis microscopic 16.76 10.42 33 531898 9306 62947785
Transplant dysfunction 16.75 10.42 10 531921 4862 62952229
Ileus 16.72 10.42 65 531866 14660 62942431
Salivary hypersecretion 16.60 10.42 24 531907 7642 62949449
Incorrect product administration duration 16.55 10.42 46 531885 11500 62945591
Sensitisation 16.53 10.42 4 531927 3382 62953709
Multiple drug therapy 16.50 10.42 5 531926 3641 62953450
Klebsiella infection 16.49 10.42 29 531902 8537 62948554
Muscular weakness 16.49 10.42 847 531084 121506 62835585
Aspiration 16.48 10.42 42 531889 10809 62946282
Oliguria 16.47 10.42 32 531899 9069 62948022
Hepatitis cholestatic 16.46 10.42 20 531911 6858 62950233
Neutropenic colitis 16.46 10.42 3 531928 3092 62953999
Macular degeneration 16.43 10.42 128 531803 24248 62932843
Antibody test positive 16.40 10.42 55 531876 2652 62954439
Renal injury 16.38 10.42 34 531897 9405 62947686
Polyhydramnios 16.38 10.42 49 531882 2222 62954869
Human antichimeric antibody positive 16.37 10.42 41 531890 1673 62955418
Polyuria 16.37 10.42 29 531902 8513 62948578
Congenital arterial malformation 16.34 10.42 17 531914 320 62956771
Acute pulmonary oedema 16.27 10.42 27 531904 8131 62948960
Mucosal inflammation 16.16 10.42 286 531645 46642 62910449
Cushingoid 16.08 10.42 124 531807 8361 62948730
Feeling hot 16.06 10.42 311 531620 50043 62907048
Hypertransaminasaemia 16.05 10.42 19 531912 6590 62950501
Urinary incontinence 16.04 10.42 181 531750 31833 62925258
Bradykinesia 16.02 10.42 12 531919 5176 62951915
Laryngospasm 15.97 10.42 3 531928 3025 62954066
Paraesthesia 15.93 10.42 1116 530815 155850 62801241
Toxic encephalopathy 15.89 10.42 19 531912 6560 62950531
Right ventricular failure 15.83 10.42 82 531849 17106 62939985
Renal tubular necrosis 15.80 10.42 49 531882 11829 62945262
Product adhesion issue 15.79 10.42 10 531921 4709 62952382
Tinnitus 15.74 10.42 207 531724 35421 62921670
Treatment noncompliance 15.71 10.42 219 531712 37106 62919985
Product administered to patient of inappropriate age 15.69 10.42 4 531927 3264 62953827
Subarachnoid haemorrhage 15.62 10.42 64 531867 14219 62942872
Scleritis 15.60 10.42 76 531855 4352 62952739
Injury 15.58 10.42 757 531174 72490 62884601
Respiratory acidosis 15.58 10.42 20 531911 6695 62950396
Affect lability 15.56 10.42 45 531886 11106 62945985
Peripheral sensory neuropathy 15.49 10.42 24 531907 7427 62949664
Headache 15.43 10.42 4908 527023 628333 62328758
Fracture delayed union 15.38 10.42 50 531881 2372 62954719
Product preparation error 15.35 10.42 17 531914 6075 62951016
Breast cancer female 15.30 10.42 60 531871 13499 62943592
Dysuria 15.28 10.42 195 531736 33543 62923548
Bone lesion 15.28 10.42 16 531915 5865 62951226
Pallor 15.25 10.42 173 531758 30395 62926696
Epilepsy 15.19 10.42 149 531782 26916 62930175
Presyncope 15.17 10.42 154 531777 27631 62929460
Dermatitis exfoliative 15.16 10.42 14 531917 5445 62951646
Lupus vulgaris 15.15 10.42 94 531837 5900 62951191
Postoperative wound infection 15.14 10.42 149 531782 10776 62946315
Cytomegalovirus viraemia 15.09 10.42 15 531916 5634 62951457
Cholecystitis chronic 15.06 10.42 41 531890 10320 62946771
Sleep disorder due to a general medical condition 15.03 10.42 52 531879 12136 62944955
Multiple allergies 14.99 10.42 62 531869 13740 62943351
Pulseless electrical activity 14.90 10.42 25 531906 7496 62949595
Fear of injection 14.88 10.42 107 531824 7057 62950034
Middle insomnia 14.88 10.42 55 531876 12588 62944503
Tendonitis 14.86 10.42 239 531692 19376 62937715
Pulmonary tuberculosis 14.84 10.42 76 531855 4441 62952650
Blood parathyroid hormone decreased 14.79 10.42 136 531795 9655 62947436
Acute coronary syndrome 14.77 10.42 40 531891 10086 62947005
Stillbirth 14.71 10.42 102 531829 6648 62950443
Hyperuricaemia 14.65 10.42 14 531917 5356 62951735
Breast feeding 14.46 10.42 26 531905 839 62956252
Dementia 14.46 10.42 95 531836 18699 62938392
Haematemesis 14.44 10.42 174 531757 30238 62926853
Hypernatraemia 14.43 10.42 26 531905 7583 62949508
Bundle branch block left 14.42 10.42 23 531908 7036 62950055
Tumour marker increased 14.38 10.42 12 531919 4903 62952188
Myopathy 14.31 10.42 47 531884 11144 62945947
Carotid artery thrombosis 14.25 10.42 3 531928 2791 62954300
Injection site warmth 14.20 10.42 192 531739 15003 62942088
Granuloma skin 14.20 10.42 120 531811 8317 62948774
Ear infection 14.17 10.42 420 531511 37793 62919298
Atrial tachycardia 14.17 10.42 9 531922 4231 62952860
Oedema peripheral 14.13 10.42 1381 530550 188130 62768961
Personality change 13.98 10.42 23 531908 6950 62950141
Illness 13.88 10.42 309 531622 48750 62908341
Exomphalos 13.77 10.42 20 531911 537 62956554
Multiple sclerosis 13.76 10.42 134 531797 24238 62932853
Hypocalcaemia 13.73 10.42 185 531746 31528 62925563
Device breakage 13.72 10.42 50 531881 11492 62945599
Visual impairment 13.70 10.42 573 531358 83873 62873218
Head injury 13.68 10.42 155 531776 27241 62929850
Crohn's disease 13.67 10.42 79 531852 4834 62952257
Hypercholesterolaemia 13.65 10.42 253 531678 21081 62936010
Amylase increased 13.61 10.42 20 531911 6325 62950766
Transaminases increased 13.58 10.42 183 531748 31184 62925907
Wrong product administered 13.53 10.42 19 531912 6122 62950969
Electrocardiogram QRS complex prolonged 13.45 10.42 18 531913 5920 62951171
Nephropathy toxic 13.41 10.42 38 531893 9441 62947650
Inadequate analgesia 13.38 10.42 4 531927 2939 62954152
Colorectal cancer 13.23 10.42 7 531924 3638 62953453
Pulmonary haemorrhage 13.21 10.42 25 531906 7156 62949935
Mood altered 13.21 10.42 71 531860 14672 62942419
Skin toxicity 13.20 10.42 12 531919 4702 62952389
Gastroschisis 13.20 10.42 17 531914 406 62956685
Short stature 13.18 10.42 22 531909 668 62956423
Food allergy 13.16 10.42 50 531881 11351 62945740
Cyst 13.12 10.42 178 531753 13921 62943170
Autism spectrum disorder 13.10 10.42 25 531906 845 62956246
Squamous cell carcinoma 13.09 10.42 120 531811 8512 62948579
Respiration abnormal 13.02 10.42 21 531910 6396 62950695
Glomerular filtration rate decreased 13.02 10.42 63 531868 13378 62943713
Device dislocation 13.01 10.42 145 531786 25560 62931531
Abortion incomplete 12.95 10.42 5 531926 3126 62953965
Pulmonary alveolar haemorrhage 12.93 10.42 12 531919 4656 62952435
Sciatica 12.93 10.42 378 531553 33946 62923145
Erythema 12.93 10.42 1282 530649 174469 62782622
Onychomycosis 12.92 10.42 112 531819 7820 62949271
Metastases to lymph nodes 12.84 10.42 31 531900 8127 62948964
Epistaxis 12.76 10.42 489 531442 72236 62884855
Adenovirus infection 12.75 10.42 7 531924 3564 62953527
Blood lactic acid increased 12.75 10.42 25 531906 7061 62950030
Product substitution issue 12.75 10.42 80 531851 15916 62941175
Visual acuity reduced 12.74 10.42 119 531812 21707 62935384
Hyperthermia 12.74 10.42 37 531894 9119 62947972
Intracranial pressure increased 12.72 10.42 15 531916 5212 62951879
Polydipsia 12.71 10.42 7 531924 3557 62953534
Hypoglycaemic coma 12.66 10.42 3 531928 2572 62954519
Neutrophilia 12.60 10.42 11 531920 4395 62952696
Ulcer 12.59 10.42 297 531634 25810 62931281
Bundle branch block right 12.54 10.42 14 531917 4984 62952107
Coordination abnormal 12.52 10.42 66 531865 13707 62943384
Joint noise 12.46 10.42 71 531860 4321 62952770
Haemorrhage in pregnancy 12.46 10.42 40 531891 1885 62955206
Fracture 12.45 10.42 232 531699 19352 62937739
Product physical issue 12.44 10.42 14 531917 4966 62952125
Lymph gland infection 12.43 10.42 18 531913 482 62956609
Anger 12.29 10.42 58 531873 12398 62944693
Nasal obstruction 12.16 10.42 37 531894 1694 62955397
Blood urea increased 12.12 10.42 152 531779 26227 62930864
Speech disorder developmental 12.09 10.42 21 531910 659 62956432
Ankle arthroplasty 12.04 10.42 38 531893 1775 62955316
Intervertebral disc degeneration 12.03 10.42 192 531739 15540 62941551
Abdominal pain upper 12.03 10.42 1530 530401 204914 62752177
Gestational hypertension 11.99 10.42 46 531885 2371 62954720
Plasma cell myeloma 11.99 10.42 220 531711 35685 62921406
Oligoarthritis 11.99 10.42 19 531912 552 62956539
Learning disorder 11.98 10.42 21 531910 664 62956427
Congenital cerebral cyst 11.96 10.42 13 531918 258 62956833
Cardiac disorder 11.95 10.42 329 531602 50487 62906604
Pregnancy with contraceptive device 11.94 10.42 13 531918 4681 62952410
Progressive multifocal leukoencephalopathy 11.88 10.42 62 531869 12909 62944182
Hypertelorism 11.86 10.42 17 531914 451 62956640
Talipes 11.85 10.42 34 531897 1506 62955585
Infusion site swelling 11.83 10.42 42 531889 9728 62947363
Blood iron increased 11.82 10.42 34 531897 1508 62955583
Post-traumatic stress disorder 11.81 10.42 16 531915 5235 62951856
Pneumonia viral 11.77 10.42 31 531900 7891 62949200
Tongue disorder 11.73 10.42 138 531793 10442 62946649
Blood phosphorus decreased 11.70 10.42 12 531919 4441 62952650
Dactylitis 11.59 10.42 48 531883 2564 62954527
Hyperbilirubinaemia 11.57 10.42 52 531879 11262 62945829
Induced labour 11.56 10.42 25 531906 926 62956165
Sleep terror 11.55 10.42 4 531927 2676 62954415
Premature delivery 11.55 10.42 334 531597 29947 62927144
Panniculitis 11.54 10.42 146 531785 11239 62945852
Joint lock 11.48 10.42 44 531887 2267 62954824
Haemodynamic instability 11.47 10.42 39 531892 9151 62947940
Dermatitis acneiform 11.47 10.42 15 531916 4981 62952110
Blood lactate dehydrogenase increased 11.46 10.42 131 531800 22985 62934106
Ejection fraction 11.44 10.42 3 531928 2403 62954688
Contrast media allergy 11.41 10.42 3 531928 2398 62954693
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.39 10.42 5 531926 2894 62954197
Disturbance in social behaviour 11.38 10.42 10 531921 3983 62953108
Device issue 11.31 10.42 136 531795 23645 62933446
Skin plaque 11.30 10.42 34 531897 8286 62948805
Troponin increased 11.29 10.42 45 531886 10076 62947015
Bacteraemia 11.28 10.42 92 531839 17256 62939835
Ingrown hair 11.27 10.42 19 531912 582 62956509
Nail injury 11.26 10.42 20 531911 639 62956452
Breast cancer metastatic 11.26 10.42 57 531874 11961 62945130
Cyst rupture 11.22 10.42 20 531911 641 62956450
Chronic graft versus host disease 11.19 10.42 6 531925 3096 62953995
Hypoventilation 11.19 10.42 14 531917 4740 62952351
Hepatic necrosis 11.18 10.42 19 531912 5668 62951423
Diabetes insipidus 11.18 10.42 4 531927 2621 62954470
Human anti-human antibody test 11.17 10.42 16 531915 424 62956667
Potentiating drug interaction 11.15 10.42 12 531919 4344 62952747
Nystagmus 11.14 10.42 22 531909 6198 62950893
Ileus paralytic 11.14 10.42 13 531918 4538 62952553
Oropharyngeal pain 11.14 10.42 928 531003 93559 62863532
Lymphatic fistula 11.12 10.42 22 531909 764 62956327
Catheter site pain 11.09 10.42 14 531917 4721 62952370
Mouth ulceration 11.03 10.42 358 531573 32626 62924465
Maternal exposure during breast feeding 11.03 10.42 67 531864 4174 62952917
Incoherent 11.03 10.42 13 531918 4517 62952574
Hereditary angioedema 10.93 10.42 30 531901 7532 62949559
Cervical incompetence 10.90 10.42 19 531912 598 62956493
Injection site haematoma 10.88 10.42 96 531835 6736 62950355
Hot flush 10.83 10.42 336 531595 50823 62906268
Foetal distress syndrome 10.74 10.42 30 531901 1308 62955783
Catatonia 10.74 10.42 13 531918 4464 62952627
Hepatitis fulminant 10.71 10.42 8 531923 3456 62953635
Catheter site erythema 10.70 10.42 12 531919 4264 62952827
Foot operation 10.70 10.42 100 531831 7131 62949960
Electrolyte imbalance 10.66 10.42 112 531819 19964 62937127
Septic shock 10.62 10.42 453 531478 66176 62890915
Infusion site erythema 10.60 10.42 56 531875 11623 62945468
Terminal state 10.56 10.42 3 531928 2279 62954812
Endodontic procedure 10.56 10.42 54 531877 3153 62953938
Bronchial secretion retention 10.55 10.42 5 531926 2768 62954323
Atrial flutter 10.55 10.42 44 531887 9728 62947363
Uterine perforation 10.54 10.42 27 531904 6936 62950155
Cleft lip and palate 10.51 10.42 19 531912 616 62956475
Forceps delivery 10.49 10.42 11 531920 209 62956882
Bone density increased 10.47 10.42 21 531910 737 62956354
Drug screen positive 10.45 10.42 9 531922 3620 62953471
Syndactyly 10.45 10.42 16 531915 451 62956640

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 551.64 10.18 831 182603 37407 34736090
Drug abuse 378.03 10.18 40 183394 99056 34674441
Toxicity to various agents 303.65 10.18 363 183071 199999 34573498
Completed suicide 277.49 10.18 85 183349 98083 34675414
Foetal exposure during pregnancy 266.38 10.18 606 182828 37495 34736002
Arthralgia 241.11 10.18 1622 181812 168419 34605078
Psoriatic arthropathy 195.22 10.18 363 183071 19435 34754062
Drug interaction 178.60 10.18 599 182835 225347 34548150
Sickle cell anaemia with crisis 141.37 10.18 138 183296 3915 34769582
Joint swelling 139.14 10.18 653 182781 59237 34714260
Dysmorphism 128.34 10.18 117 183317 3039 34770458
Intentional overdose 116.01 10.18 42 183392 43632 34729865
Psoriasis 112.97 10.18 453 182981 38359 34735138
Musculoskeletal stiffness 100.48 10.18 498 182936 46182 34727315
Acute kidney injury 92.47 10.18 1090 182344 303898 34469599
Premature baby 90.36 10.18 267 183167 19366 34754131
Product use in unapproved indication 85.63 10.18 322 183112 117177 34656320
Blood pressure fluctuation 84.40 10.18 308 183126 24941 34748556
Enthesopathy 82.27 10.18 111 183323 4502 34768995
Synovitis 80.32 10.18 207 183227 13859 34759638
Tenosynovitis 77.03 10.18 107 183327 4463 34769034
Exposure during pregnancy 76.07 10.18 154 183280 8780 34764717
Arthropathy 71.95 10.18 306 183128 26601 34746896
Speech disorder developmental 71.35 10.18 72 183362 2128 34771369
Pain 71.29 10.18 1487 181947 203188 34570309
Overdose 69.99 10.18 244 183190 90815 34682682
Coma 69.80 10.18 82 183352 45596 34727901
C-reactive protein abnormal 69.30 10.18 146 183288 8564 34764933
Drug reaction with eosinophilia and systemic symptoms 67.62 10.18 45 183389 32967 34740530
Hepatic function abnormal 67.41 10.18 80 183354 44283 34729214
Suicide attempt 66.73 10.18 64 183370 39052 34734445
Rhabdomyolysis 64.35 10.18 166 183268 67997 34705500
Death 63.44 10.18 1598 181836 396451 34377046
Foetal anticonvulsant syndrome 60.38 10.18 50 183384 1137 34772360
Neonatal respiratory distress syndrome 60.00 10.18 89 183345 3945 34769552
Febrile neutropenia 59.40 10.18 447 182987 136402 34637095
Nasopharyngitis 57.63 10.18 591 182843 69377 34704120
Maternal exposure during pregnancy 57.26 10.18 97 183337 4821 34768676
Blood pressure systolic increased 56.77 10.18 255 183179 22697 34750800
Serotonin syndrome 56.73 10.18 17 183417 19916 34753581
Hypospadias 55.53 10.18 76 183358 3125 34770372
Atrial septal defect 55.46 10.18 121 183313 7271 34766226
Alanine aminotransferase abnormal 55.29 10.18 93 183341 4595 34768902
Arthritis 54.87 10.18 316 183118 31030 34742467
Multiple organ dysfunction syndrome 54.34 10.18 212 183222 76354 34697143
Drug dependence 53.80 10.18 30 183404 24187 34749310
Low birth weight baby 51.11 10.18 122 183312 7783 34765714
Autism spectrum disorder 50.00 10.18 61 183373 2235 34771262
Maternal drugs affecting foetus 49.91 10.18 81 183353 3884 34769613
Drug resistance 49.61 10.18 38 183396 25889 34747608
Intentional product misuse 49.55 10.18 103 183331 45508 34727989
Learning disorder 49.43 10.18 43 183391 1048 34772449
Cryptorchism 49.01 10.18 57 183377 1984 34771513
Peripheral swelling 47.94 10.18 613 182821 75928 34697569
Hypoglycaemia neonatal 47.18 10.18 54 183380 1847 34771650
Small for dates baby 45.12 10.18 77 183357 3850 34769647
Disease progression 45.01 10.18 357 183077 107720 34665777
Bradycardia 44.34 10.18 224 183210 75194 34698303
Ventricular septal defect 44.07 10.18 77 183357 3924 34769573
Rheumatoid nodule 43.80 10.18 65 183369 2882 34770615
Blood pressure systolic abnormal 43.51 10.18 76 183358 3872 34769625
Tongue disorder 43.06 10.18 90 183344 5249 34768248
Maternal exposure during breast feeding 42.06 10.18 46 183388 1495 34772002
Angioedema 41.78 10.18 83 183351 37291 34736206
Pain in extremity 41.65 10.18 912 182522 125601 34647896
Off label use 41.14 10.18 1792 181642 417732 34355765
Cytomegalovirus infection 40.92 10.18 46 183388 26089 34747408
Delirium 40.85 10.18 108 183326 43883 34729614
Syndactyly 40.58 10.18 35 183399 843 34772654
Cardiac failure 40.06 10.18 297 183137 90951 34682546
Osteoarthritis 39.38 10.18 213 183221 20429 34753068
Joint effusion 38.96 10.18 85 183349 5108 34768389
Blood pressure diastolic abnormal 38.60 10.18 81 183353 4737 34768760
Haemoglobin decreased 37.98 10.18 865 182569 119907 34653590
Hand deformity 37.58 10.18 69 183365 3656 34769841
Altered state of consciousness 37.27 10.18 39 183395 22854 34750643
Psychotic disorder 37.24 10.18 44 183390 24408 34749089
Respiratory arrest 37.07 10.18 56 183378 27987 34745510
Palmar-plantar erythrodysaesthesia syndrome 37.02 10.18 21 183413 16774 34756723
Renal failure 36.99 10.18 473 182961 130084 34643413
Basal cell carcinoma 36.93 10.18 202 183232 19456 34754041
Developmental delay 36.73 10.18 58 183376 2717 34770780
Blood pressure increased 36.67 10.18 658 182776 87444 34686053
Depressed level of consciousness 36.22 10.18 110 183324 42731 34730766
Foot deformity 36.03 10.18 76 183358 4461 34769036
Blood pressure diastolic decreased 35.66 10.18 117 183317 8977 34764520
Poisoning 35.58 10.18 10 183424 12216 34761281
Somnolence 35.53 10.18 392 183042 110724 34662773
Tendonitis 35.31 10.18 117 183317 9023 34764474
Heart rate decreased 35.21 10.18 286 183148 31459 34742038
Pancytopenia 34.90 10.18 697 182737 94460 34679037
Weight decreased 34.43 10.18 1188 182246 175113 34598384
Sedation 33.96 10.18 36 183398 20970 34752527
Talipes 33.88 10.18 46 183388 1877 34771620
Exposure via breast milk 33.78 10.18 47 183387 1963 34771534
Infusion related reaction 33.67 10.18 426 183008 52631 34720866
Joint laxity 33.55 10.18 23 183411 389 34773108
Pulmonary fibrosis 33.21 10.18 187 183247 18209 34755288
Drug intolerance 33.13 10.18 467 182967 59103 34714394
C-reactive protein increased 32.91 10.18 431 183003 53667 34719830
Grip strength decreased 32.35 10.18 59 183375 3110 34770387
Immune reconstitution inflammatory syndrome 32.20 10.18 4 183430 8755 34764742
Knee arthroplasty 32.14 10.18 99 183335 7345 34766152
Lower respiratory tract infection 31.37 10.18 278 183156 31359 34742138
Musculoskeletal pain 31.25 10.18 280 183154 31683 34741814
Suicidal ideation 31.16 10.18 108 183326 40280 34733217
Pathogen resistance 31.07 10.18 6 183428 9476 34764021
Lactic acidosis 31.05 10.18 87 183347 34685 34738812
Red blood cell sedimentation rate increased 30.81 10.18 112 183322 9050 34764447
Congenital hand malformation 30.13 10.18 25 183409 570 34772927
Cardiac arrest 30.04 10.18 341 183093 95818 34677679
Plagiocephaly 29.80 10.18 24 183410 524 34772973
Renal impairment 29.19 10.18 336 183098 94177 34679320
Hypermobility syndrome 28.83 10.18 20 183414 345 34773152
Shock 28.51 10.18 52 183382 24127 34749370
Caesarean section 28.32 10.18 45 183389 2119 34771378
Jaundice neonatal 28.08 10.18 35 183399 1311 34772186
Fatigue 27.96 10.18 2282 181152 368371 34405126
Finger deformity 27.89 10.18 37 183397 1476 34772021
Dysgraphia 27.81 10.18 46 183388 2241 34771256
Drug withdrawal syndrome 27.80 10.18 38 183396 19796 34753701
Acute hepatic failure 27.73 10.18 20 183414 14054 34759443
Neuroleptic malignant syndrome 27.60 10.18 32 183402 17902 34755595
Cardiogenic shock 27.34 10.18 62 183372 26556 34746941
Polyarthritis 27.15 10.18 68 183366 4472 34769025
Foetal growth restriction 27.11 10.18 64 183370 4053 34769444
Agitation 27.05 10.18 183 183251 57216 34716281
Appendicolith 27.03 10.18 6 183428 8595 34764902
Astigmatism 26.95 10.18 31 183403 1066 34772431
Language disorder 26.93 10.18 45 183389 2211 34771286
Wound 26.76 10.18 151 183283 14713 34758784
Acute chest syndrome 26.70 10.18 27 183407 800 34772697
Intellectual disability 26.66 10.18 34 183400 1304 34772193
Intentional self-injury 26.58 10.18 20 183414 13751 34759746
Diaphragmatic disorder 26.36 10.18 33 183401 1242 34772255
Hypoglycaemia 26.35 10.18 173 183261 54467 34719030
Large for dates baby 26.10 10.18 28 183406 890 34772607
Ankylosing spondylitis 25.58 10.18 76 183358 5528 34767969
Rash maculo-papular 25.54 10.18 71 183363 28380 34745117
Anal fistula 25.39 10.18 74 183360 5325 34768172
Colitis ulcerative 25.38 10.18 161 183273 16359 34757138
Hyperglycaemia 25.10 10.18 114 183320 39366 34734131
Tuberculosis 24.85 10.18 100 183334 8477 34765020
Substance abuse 24.69 10.18 5 183429 7636 34765861
Hydrops foetalis 23.87 10.18 26 183408 841 34772656
Body temperature decreased 23.86 10.18 133 183301 12901 34760596
Neurotoxicity 23.77 10.18 36 183398 17974 34755523
Skin cancer 23.68 10.18 112 183322 10185 34763312
Respiratory failure 23.61 10.18 414 183020 108158 34665339
Hypotonia neonatal 23.43 10.18 32 183402 1313 34772184
Oropharyngeal pain 23.40 10.18 287 183147 35198 34738299
Ultrasound antenatal screen 23.37 10.18 21 183413 535 34772962
Hepatic failure 22.98 10.18 98 183336 34433 34739064
Respiratory depression 22.90 10.18 31 183403 16214 34757283
Anaphylactic shock 22.89 10.18 30 183404 15911 34757586
Inflammation 22.80 10.18 238 183196 28057 34745440
Blood pressure diastolic increased 22.79 10.18 68 183366 4957 34768540
Otitis media 22.68 10.18 48 183386 2824 34770673
Hyperbilirubinaemia neonatal 22.49 10.18 24 183410 758 34772739
Vitamin D deficiency 22.40 10.18 81 183353 6527 34766970
Haematocrit decreased 22.31 10.18 263 183171 31953 34741544
Venoocclusive liver disease 22.30 10.18 7 183427 7959 34765538
Blood creatine phosphokinase increased 22.15 10.18 141 183293 44716 34728781
Selective eating disorder 21.94 10.18 36 183398 1742 34771755
Knee deformity 21.92 10.18 22 183412 646 34772851
Motor developmental delay 21.92 10.18 22 183412 646 34772851
Therapeutic product effect decreased 21.63 10.18 278 183156 34465 34739032
Drug withdrawal syndrome neonatal 21.43 10.18 54 183380 3565 34769932
Dyspraxia 21.38 10.18 18 183416 419 34773078
Radiation inflammation 21.27 10.18 25 183409 880 34772617
Nasal disorder 21.10 10.18 37 183397 1891 34771606
Trisomy 18 21.02 10.18 23 183411 748 34772749
Joint stiffness 20.61 10.18 112 183322 10761 34762736
Ear disorder 20.56 10.18 34 183400 1656 34771841
Ear infection 20.49 10.18 107 183327 10124 34763373
Back disorder 20.44 10.18 79 183355 6572 34766925
Post procedural infection 20.43 10.18 64 183370 4792 34768705
Hydrocele 20.23 10.18 38 183396 2049 34771448
Toxic epidermal necrolysis 20.20 10.18 53 183381 21593 34751904
Malignant neoplasm progression 20.02 10.18 333 183101 87713 34685784
Foetal disorder 19.72 10.18 23 183411 803 34772694
Cholestasis 19.50 10.18 74 183360 26874 34746623
Cleft lip and palate 19.49 10.18 24 183410 888 34772609
Joint range of motion decreased 19.42 10.18 83 183351 7229 34766268
Wrong technique in product usage process 19.41 10.18 110 183324 35876 34737621
Malignant melanoma 19.34 10.18 89 183345 8001 34765496
Infection 19.34 10.18 619 182815 90296 34683201
Sinusitis 19.30 10.18 315 183119 41087 34732410
Arthritis infective 19.19 10.18 50 183384 3369 34770128
Congenital foot malformation 19.18 10.18 17 183417 425 34773072
Umbilical hernia 19.09 10.18 61 183373 4616 34768881
Crohn's disease 18.97 10.18 47 183387 3070 34770427
Dyslexia 18.96 10.18 15 183419 319 34773178
Agranulocytosis 18.84 10.18 63 183371 23758 34749739
Red blood cell sedimentation rate 18.81 10.18 27 183407 1161 34772336
Cellulitis 18.78 10.18 386 183048 52565 34720932
Respiratory disorder neonatal 18.78 10.18 32 183402 1598 34771899
Gastrointestinal infection 18.76 10.18 70 183364 5728 34767769
Localised infection 18.72 10.18 157 183277 17430 34756067
Strabismus 18.66 10.18 33 183401 1698 34771799
Limb reduction defect 18.55 10.18 14 183420 277 34773220
Anal fissure 18.47 10.18 57 183377 4233 34769264
Incorrect route of product administration 18.34 10.18 31 183403 14814 34758683
Blood parathyroid hormone decreased 18.31 10.18 30 183404 1450 34772047
Tachycardia 18.18 10.18 324 183110 84448 34689049
Electrocardiogram QT prolonged 18.10 10.18 133 183301 40819 34732678
Serum ferritin increased 18.08 10.18 72 183362 6074 34767423
Akathisia 18.07 10.18 10 183424 8099 34765398
Loss of personal independence in daily activities 17.99 10.18 259 183175 32920 34740577
Abdominal discomfort 17.99 10.18 426 183008 59409 34714088
Poor venous access 17.97 10.18 64 183370 5119 34768378
Ventricular fibrillation 17.96 10.18 61 183373 22893 34750604
Influenza 17.93 10.18 363 183071 49303 34724194
No adverse event 17.89 10.18 61 183373 22866 34750631
Spinal disorder 17.85 10.18 56 183378 4196 34769301
Sleep disorder due to a general medical condition 17.76 10.18 3 183431 5218 34768279
Juvenile idiopathic arthritis 17.72 10.18 34 183400 1863 34771634
Cerebral haemorrhage 17.67 10.18 109 183325 34828 34738669
Arthritis bacterial 17.66 10.18 63 183371 5043 34768454
Medical device implantation 17.63 10.18 19 183415 607 34772890
Agitation neonatal 17.49 10.18 25 183409 1071 34772426
Multiple congenital abnormalities 17.46 10.18 18 183416 546 34772951
Lung neoplasm malignant 17.32 10.18 153 183281 17242 34756255
Granuloma skin 17.30 10.18 27 183407 1252 34772245
Proteinuria 17.12 10.18 46 183388 18596 34754901
Stevens-Johnson syndrome 17.11 10.18 46 183388 18593 34754904
Attention deficit hyperactivity disorder 17.09 10.18 40 183394 2519 34770978
Hypertelorism 16.99 10.18 18 183416 564 34772933
Metabolic acidosis 16.93 10.18 147 183287 43533 34729964
Congenital anomaly 16.92 10.18 28 183406 1365 34772132
Fall 16.86 10.18 1259 182175 201626 34571871
Lacrimal disorder 16.77 10.18 14 183420 322 34773175
Vomiting 16.76 10.18 1097 182337 246524 34526973
Cleft lip 16.74 10.18 14 183420 323 34773174
Congenital bladder anomaly 16.69 10.18 13 183421 270 34773227
Weight decrease neonatal 16.66 10.18 14 183420 325 34773172
Immunodeficiency 16.65 10.18 65 183369 5433 34768064
Pyrexia 16.64 10.18 1513 181921 331500 34441997
Drug level increased 16.43 10.18 60 183374 22036 34751461
Pectus excavatum 16.22 10.18 12 183422 230 34773267
Ankyloglossia congenital 16.14 10.18 13 183421 284 34773213
Renal aplasia 16.11 10.18 20 183414 746 34772751
Aggression 16.06 10.18 129 183305 38835 34734662
Synovial cyst 16.05 10.18 37 183397 2307 34771190
Second primary malignancy 15.81 10.18 11 183423 7875 34765622
Haematochezia 15.78 10.18 337 183097 46197 34727300
Joint ankylosis 15.71 10.18 29 183405 1543 34771954
Ventricular tachycardia 15.58 10.18 79 183355 26500 34746997
Suspected suicide 15.57 10.18 3 183431 4745 34768752
Hyperammonaemia 15.47 10.18 7 183427 6360 34767137
Withdrawal syndrome 15.40 10.18 26 183408 12429 34761068
C-reactive protein decreased 15.28 10.18 33 183401 1969 34771528
Sexual dysfunction 15.21 10.18 7 183427 6296 34767201
Microcephaly 15.21 10.18 20 183414 791 34772706
Neck mass 15.18 10.18 29 183405 1584 34771913
Disseminated intravascular coagulation 15.09 10.18 61 183373 21755 34751742
Haemangioma congenital 15.08 10.18 16 183418 502 34772995
Skin injury 14.95 10.18 36 183398 2309 34771188
Upper respiratory tract infection 14.85 10.18 250 183184 32809 34740688
Patent ductus arteriosus 14.85 10.18 45 183389 3309 34770188
Behaviour disorder 14.83 10.18 58 183376 4852 34768645
Scoliosis 14.82 10.18 40 183394 2753 34770744
Anti-cyclic citrullinated peptide antibody positive 14.78 10.18 31 183403 1812 34771685
Arthrodesis 14.76 10.18 15 183419 447 34773050
Latent tuberculosis 14.71 10.18 26 183408 1337 34772160
Abortion spontaneous 14.67 10.18 14 183420 386 34773111
Hypokalaemia 14.63 10.18 216 183218 57998 34715499
Nephrolithiasis 14.59 10.18 232 183202 30101 34743396
Weight increased 14.56 10.18 612 182822 92421 34681076
Myoclonus 14.56 10.18 35 183399 14690 34758807
Acute graft versus host disease 14.52 10.18 8 183426 6495 34767002
Osteonecrosis of jaw 14.36 10.18 47 183387 17842 34755655
Respiratory rate increased 14.32 10.18 95 183339 9799 34763698
Oesophageal fibrosis 14.25 10.18 10 183424 176 34773321
Electrocardiogram QRS complex prolonged 14.24 10.18 4 183430 4890 34768607
Diverticular perforation 14.21 10.18 45 183389 3389 34770108
Heart rate irregular 14.20 10.18 136 183298 15671 34757826
Hernia pain 14.20 10.18 12 183422 281 34773216
Cystitis haemorrhagic 14.19 10.18 6 183428 5673 34767824
Drug ineffective for unapproved indication 14.18 10.18 70 183364 23645 34749852
Arnold-Chiari malformation 14.15 10.18 13 183421 341 34773156
Kidney infection 14.15 10.18 61 183373 5333 34768164
Bone cyst 14.12 10.18 28 183406 1572 34771925
Fistula discharge 14.09 10.18 20 183414 851 34772646
Tooth malformation 14.01 10.18 10 183424 181 34773316
Hepatic enzyme increased 13.89 10.18 285 183149 38795 34734702
Aspergillus infection 13.88 10.18 27 183407 12227 34761270
Bradycardia neonatal 13.76 10.18 21 183413 955 34772542
Melaena 13.74 10.18 119 183315 35261 34738236
Injection site pain 13.72 10.18 284 183150 38721 34734776
Developmental coordination disorder 13.55 10.18 10 183424 191 34773306
Oxygen saturation decreased 13.49 10.18 374 183060 53444 34720053
Bronchiolitis 13.49 10.18 42 183392 3134 34770363
Nodule 13.44 10.18 71 183363 6748 34766749
Autoscopy 13.44 10.18 11 183423 246 34773251
Septic arthritis staphylococcal 13.39 10.18 15 183419 501 34772996
Vitamin B12 deficiency 13.32 10.18 49 183385 3982 34769515
Maternal exposure timing unspecified 13.28 10.18 13 183421 370 34773127
Foetal heart rate deceleration abnormality 13.27 10.18 15 183419 506 34772991
Foetal distress syndrome 13.21 10.18 22 183412 1078 34772419
Panniculitis 13.13 10.18 31 183403 1963 34771534
Hepatitis E antibody positive 13.07 10.18 11 183423 256 34773241
Haemangioma 13.05 10.18 30 183404 1867 34771630
Polydactyly 12.91 10.18 23 183411 1190 34772307
BK virus infection 12.90 10.18 7 183427 5731 34767766
Low set ears 12.80 10.18 14 183420 455 34773042
Abdominal adhesions 12.78 10.18 26 183408 1487 34772010
Nerve compression 12.69 10.18 42 183392 3237 34770260
Blood test abnormal 12.67 10.18 71 183363 6900 34766597
Fistula 12.65 10.18 70 183364 6770 34766727
Maternal exposure before pregnancy 12.56 10.18 18 183416 773 34772724
Cardiotoxicity 12.54 10.18 7 183427 5641 34767856
Pleuritic pain 12.51 10.18 44 183390 3497 34770000
Adenovirus infection 12.43 10.18 6 183428 5251 34768246
Educational problem 12.35 10.18 15 183419 547 34772950
Respiratory tract infection viral 12.32 10.18 35 183399 2482 34771015
Cardio-respiratory arrest 12.25 10.18 210 183224 55063 34718434
Vascular insufficiency 12.25 10.18 12 183422 342 34773155
Product quality issue 12.18 10.18 47 183387 16988 34756509
Red blood cell sedimentation rate abnormal 12.17 10.18 44 183390 3545 34769952
Headache 12.11 10.18 1216 182218 199419 34574078
Posterior reversible encephalopathy syndrome 12.10 10.18 21 183413 9933 34763564
Blood insulin increased 12.08 10.18 12 183422 348 34773149
Inguinal hernia 12.07 10.18 75 183359 7566 34765931
Hypertriglyceridaemia 12.03 10.18 16 183418 8432 34765065
Anal atresia 12.02 10.18 11 183423 287 34773210
Pleural fibrosis 12 10.18 24 183410 1356 34772141
Hepatitis E virus test positive 11.99 10.18 11 183423 288 34773209
Chronic graft versus host disease 11.96 10.18 4 183430 4369 34769128
Urticaria 11.96 10.18 243 183191 62134 34711363
Hallucination 11.95 10.18 194 183240 51304 34722193
Hepatocellular injury 11.92 10.18 68 183366 22143 34751354
Spina bifida 11.83 10.18 12 183422 357 34773140
Appendicitis 11.82 10.18 39 183395 14768 34758729
Hypermetropia 11.75 10.18 14 183420 500 34772997
Psychomotor retardation 11.75 10.18 44 183390 3606 34769891
Pneumonia 11.75 10.18 2117 181317 360510 34412987
Acute generalised exanthematous pustulosis 11.65 10.18 11 183423 6765 34766732
Acute respiratory distress syndrome 11.64 10.18 84 183350 25885 34747612
Mania 11.62 10.18 20 183414 9491 34764006
Ear malformation 11.56 10.18 11 183423 302 34773195
Thrombotic microangiopathy 11.54 10.18 24 183410 10606 34762891
Rheumatoid lung 11.53 10.18 19 183415 923 34772574
Progressive multifocal leukoencephalopathy 11.51 10.18 21 183413 9743 34763754
Nail pitting 11.50 10.18 11 183423 304 34773193
Diabetic ketoacidosis 11.50 10.18 52 183382 17980 34755517
Gamma-glutamyltransferase increased 11.49 10.18 98 183336 29133 34744364
Pharyngeal disorder 11.48 10.18 17 183417 752 34772745
Nail bed bleeding 11.45 10.18 12 183422 371 34773126
Bronchopulmonary aspergillosis 11.44 10.18 39 183395 14620 34758877
Hyperthermia 11.38 10.18 24 183410 10553 34762944
Gangrene neonatal 11.35 10.18 9 183425 192 34773305
Back pain 11.35 10.18 763 182671 121026 34652471
Pharyngitis 11.33 10.18 76 183358 7868 34765629
Palindromic rheumatism 11.31 10.18 9 183425 193 34773304
Contusion 11.27 10.18 260 183174 36104 34737393
Glycosylated haemoglobin increased 11.23 10.18 27 183407 11333 34762164
Loss of consciousness 11.23 10.18 339 183095 82328 34691169
Joint instability 11.17 10.18 13 183421 453 34773044
Mobility decreased 11.13 10.18 221 183213 29907 34743590
Neck pain 11.13 10.18 191 183243 25158 34748339
Abnormal behaviour 11.08 10.18 81 183353 24888 34748609
Necrotising fasciitis streptococcal 11.06 10.18 8 183426 148 34773349
Hypotension 11.04 10.18 1007 182427 220642 34552855
Cholelithiasis 11.04 10.18 164 183270 20984 34752513
Neutropenia neonatal 11.01 10.18 16 183418 696 34772801
Hypertransaminasaemia 11.00 10.18 8 183426 5598 34767899
Irritability 11.00 10.18 80 183354 24610 34748887
Vitamin B complex deficiency 10.97 10.18 12 183422 390 34773107
Red blood cell count decreased 10.96 10.18 214 183220 28876 34744621
Pulmonary alveolar haemorrhage 10.93 10.18 14 183420 7498 34765999
Gross motor delay 10.90 10.18 11 183423 325 34773172
Hepatitis 10.87 10.18 77 183357 23827 34749670
Excessive cerumen production 10.85 10.18 11 183423 327 34773170
Obsessive-compulsive disorder 10.84 10.18 8 183426 5556 34767941
Fine motor skill dysfunction 10.79 10.18 27 183407 1775 34771722
Acute graft versus host disease in skin 10.77 10.18 7 183427 5194 34768303
Peripheral artery thrombosis 10.76 10.18 32 183402 2328 34771169
Asphyxia 10.73 10.18 12 183422 6823 34766674
Eosinophilia 10.72 10.18 87 183347 26135 34747362
Exposure to toxic agent 10.70 10.18 3 183431 3672 34769825
Congenital genital malformation 10.70 10.18 8 183426 156 34773341
Injection site bruising 10.68 10.18 80 183354 8583 34764914
Hypocalcaemia 10.67 10.18 79 183355 24210 34749287
Congenital hydronephrosis 10.65 10.18 16 183418 717 34772780
Cytomegalovirus viraemia 10.65 10.18 14 183420 7416 34766081
Peritoneal dialysis complication 10.64 10.18 26 183408 1683 34771814
Neonatal infection 10.61 10.18 12 183422 405 34773092
Cardiac murmur 10.60 10.18 74 183360 7763 34765734
Transplant rejection 10.60 10.18 24 183410 10287 34763210
Dystonia 10.54 10.18 26 183408 10819 34762678
Visuospatial deficit 10.54 10.18 7 183427 112 34773385
Personality change 10.53 10.18 7 183427 5132 34768365
Diverticulum 10.52 10.18 69 183365 7090 34766407
Hallucination, auditory 10.50 10.18 30 183404 11887 34761610
End stage renal disease 10.50 10.18 19 183415 8842 34764655
Intracardiac mass 10.44 10.18 8 183426 162 34773335
Pulmonary artery stenosis congenital 10.41 10.18 13 183421 488 34773009
Blood folate increased 10.38 10.18 10 183424 279 34773218
Neonatal seizure 10.35 10.18 13 183421 491 34773006
Cytomegalovirus chorioretinitis 10.32 10.18 3 183431 3586 34769911
Gastroschisis 10.32 10.18 8 183426 165 34773332
Pulmonary pain 10.30 10.18 21 183413 1203 34772294
Meningeal disorder 10.30 10.18 11 183423 348 34773149
Bone erosion 10.22 10.18 45 183389 3970 34769527
Therapy partial responder 10.20 10.18 22 183412 9594 34763903

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1226.83 10.05 3660 540275 204810 78995643
Completed suicide 1168.88 10.05 149 543786 245618 78954835
Toxicity to various agents 1020.40 10.05 828 543107 420712 78779741
Arthropathy 977.50 10.05 3041 540894 174070 79026383
Pemphigus 953.66 10.05 2102 541833 97480 79102973
Systemic lupus erythematosus 939.83 10.05 2355 541580 118794 79081659
Joint swelling 934.28 10.05 4172 539763 284474 78915979
Hand deformity 916.54 10.05 2123 541812 101796 79098657
Synovitis 888.64 10.05 2649 541286 148085 79052368
Glossodynia 822.74 10.05 2029 541906 101308 79099145
Drug abuse 772.40 10.05 99 543836 162592 79037861
Arthralgia 744.60 10.05 6535 537400 565268 78635185
Anti-cyclic citrullinated peptide antibody positive 704.03 10.05 1672 542263 81471 79118982
Wound 690.45 10.05 2048 541887 114131 79086322
Infusion related reaction 652.06 10.05 3202 540733 227035 78973418
Maternal exposure during pregnancy 649.13 10.05 2229 541706 134309 79066144
Pericarditis 634.18 10.05 1853 542082 102383 79098070
Abdominal discomfort 597.59 10.05 3324 540611 247403 78953050
Pain 559.30 10.05 7284 536651 696518 78503935
Drug interaction 548.96 10.05 1266 542669 413917 78786536
Swelling 526.93 10.05 2889 541046 213822 78986631
Discomfort 523.09 10.05 1964 541971 123653 79076800
Therapeutic product effect decreased 510.27 10.05 2343 541592 161520 79038933
Alopecia 509.75 10.05 3004 540931 228351 78972102
Duodenal ulcer perforation 445.55 10.05 1221 542714 64990 79135463
Contraindicated product administered 444.25 10.05 2189 541746 155349 79045104
Musculoskeletal stiffness 444.20 10.05 2361 541574 172647 79027806
Helicobacter infection 442.07 10.05 1258 542677 68446 79132007
Intentional overdose 427.30 10.05 99 543836 105861 79094592
Rheumatoid factor positive 423.23 10.05 1124 542811 58715 79141738
Death 411.27 10.05 2229 541706 564285 78636168
Nasopharyngitis 398.40 10.05 3030 540905 250851 78949602
Drug intolerance 394.41 10.05 3116 540819 261003 78939450
Psoriatic arthropathy 386.89 10.05 1292 542643 76707 79123746
Hepatic enzyme increased 378.38 10.05 2334 541601 180276 79020177
Acute kidney injury 355.49 10.05 2083 541852 517321 78683132
Febrile neutropenia 332.60 10.05 671 543264 230328 78970125
Exposure during pregnancy 310.87 10.05 1441 542494 99691 79100762
Impaired healing 297.25 10.05 1286 542649 86369 79114084
Overdose 261.76 10.05 539 543396 183667 79016786
Cardiac arrest 257.96 10.05 488 543447 171608 79028845
Peripheral swelling 257.73 10.05 2893 541042 266724 78933729
Hypersensitivity 257.13 10.05 2828 541107 259411 78941042
Depressed level of consciousness 255.04 10.05 173 543762 96479 79103974
Sinusitis 247.80 10.05 2224 541711 193277 79007176
Suicide attempt 247.65 10.05 128 543807 82804 79117649
Muscle injury 247.55 10.05 812 543123 47749 79152704
C-reactive protein abnormal 246.78 10.05 809 543126 47558 79152895
Folliculitis 243.89 10.05 882 543053 54498 79145955
Treatment failure 243.69 10.05 1992 541943 168494 79031959
Irritable bowel syndrome 235.15 10.05 944 542991 61297 79139156
Lower respiratory tract infection 228.74 10.05 1588 542347 127632 79072821
Blister 227.48 10.05 1495 542440 117981 79082472
Sleep disorder due to general medical condition, insomnia type 215.49 10.05 721 543214 42835 79157618
Red blood cell sedimentation rate abnormal 213.60 10.05 454 543481 20509 79179944
Sickle cell anaemia with crisis 210.45 10.05 265 543670 7657 79192796
Arthritis 209.38 10.05 1422 542513 113458 79086995
Knee arthroplasty 207.87 10.05 709 543226 42539 79157914
Rhabdomyolysis 205.57 10.05 240 543695 102891 79097562
Bradycardia 201.71 10.05 386 543549 135171 79065282
Drug reaction with eosinophilia and systemic symptoms 201.16 10.05 93 543842 64151 79136302
Product use issue 201.13 10.05 2253 541682 207569 78992884
Osteoarthritis 197.34 10.05 1142 542793 86167 79114286
Weight increased 188.73 10.05 2796 541139 274590 78925863
Blood pressure fluctuation 188.36 10.05 932 543003 66213 79134240
Hip arthroplasty 187.75 10.05 604 543331 35152 79165301
Sedation 180.59 10.05 64 543871 51831 79148622
Respiratory arrest 174.55 10.05 87 543848 57463 79142990
Malignant neoplasm progression 171.11 10.05 425 543510 135565 79064888
Renal failure 169.45 10.05 749 543186 200219 79000234
Lactic acidosis 168.78 10.05 139 543796 70220 79130233
Disease progression 165.37 10.05 671 543264 183691 79016762
Hepatic function abnormal 165.00 10.05 153 543782 72954 79127499
Cardiac failure 164.45 10.05 525 543410 154317 79046136
Rheumatic fever 161.87 10.05 495 543440 28030 79172423
Sopor 161.72 10.05 18 543917 32992 79167461
Multiple organ dysfunction syndrome 160.68 10.05 364 543571 119882 79080571
Neutropenia 152.76 10.05 1242 542693 286468 78913985
Infection 147.37 10.05 2392 541543 239320 78961133
Contusion 146.83 10.05 1607 542328 147169 79053284
Serotonin syndrome 145.98 10.05 62 543873 44965 79155488
Fibromyalgia 145.00 10.05 841 543094 63499 79136954
Hyponatraemia 143.25 10.05 674 543261 177174 79023279
Psoriasis 142.93 10.05 1074 542861 88513 79111940
Coma 142.49 10.05 295 543640 100354 79100099
Pregnancy 139.54 10.05 452 543483 26399 79174054
Fatigue 139.17 10.05 7707 536228 922020 78278433
Abortion spontaneous 138.53 10.05 480 543455 29027 79171426
Blood pressure systolic increased 135.31 10.05 851 543084 66135 79134318
Ill-defined disorder 135.01 10.05 840 543095 65035 79135418
Swollen joint count increased 134.93 10.05 403 543532 22524 79177929
Drug resistance 133.88 10.05 60 543875 42153 79158300
Blood pressure systolic abnormal 133.26 10.05 335 543600 16912 79183541
Red blood cell sedimentation rate increased 131.92 10.05 642 543293 45300 79155153
Blood pressure diastolic abnormal 129.99 10.05 355 543580 18847 79181606
Intentional product misuse 128.83 10.05 286 543649 94879 79105574
Respiratory failure 128.50 10.05 716 543219 180195 79020258
Agitation 126.70 10.05 310 543625 99405 79101048
Hypotension 126.48 10.05 2177 541758 438140 78762313
Cytomegalovirus infection 124.09 10.05 68 543867 42576 79157877
Renal impairment 123.54 10.05 604 543331 157179 79043274
Hypoglycaemia 122.78 10.05 324 543611 101270 79099183
Joint effusion 121.91 10.05 333 543602 17681 79182772
Somnolence 121.67 10.05 1043 542892 237938 78962515
Cardio-respiratory arrest 121.53 10.05 359 543576 108151 79092302
Condition aggravated 118.36 10.05 4353 539582 496771 78703682
Electrocardiogram QT prolonged 118.01 10.05 277 543658 90109 79110344
Hepatic failure 117.14 10.05 147 543788 61065 79139388
Rash 115.66 10.05 4934 539001 573424 78627029
Product use in unapproved indication 114.74 10.05 1122 542813 249237 78951216
Drug dependence 112.95 10.05 69 543866 40700 79159753
Grip strength decreased 110.82 10.05 365 543570 21504 79178949
Constipation 109.87 10.05 1318 542617 281732 78918721
Neoplasm progression 108.75 10.05 115 543820 51567 79148886
Pain in extremity 108.67 10.05 3255 540680 361283 78839170
Intentional self-injury 107.74 10.05 43 543892 32376 79168077
Altered state of consciousness 105.81 10.05 86 543849 43736 79156717
Inflammation 104.42 10.05 1038 542897 92715 79107738
Tachycardia 103.89 10.05 747 543188 177021 79023432
Hyperglycaemia 103.09 10.05 202 543733 70133 79130320
Poisoning 103.07 10.05 23 543912 25249 79175204
C-reactive protein increased 101.11 10.05 1334 542601 127693 79072760
Injection site erythema 100.19 10.05 892 543043 77305 79123148
Angioedema 98.47 10.05 234 543701 75801 79124652
Metabolic acidosis 98.35 10.05 265 543670 82264 79118189
Thrombocytopenia 97.72 10.05 1249 542686 264010 78936443
Osteoporosis 97.46 10.05 668 543267 53444 79147009
Stomatitis 96.83 10.05 1472 542463 145285 79055168
Musculoskeletal pain 96.58 10.05 1096 542839 101258 79099195
Blood pressure diastolic decreased 95.34 10.05 434 543501 29782 79170671
Foot deformity 94.82 10.05 370 543565 23704 79176749
Respiratory depression 94.56 10.05 35 543900 27595 79172858
Enthesopathy 94.47 10.05 230 543705 11378 79189075
Rheumatoid nodule 91.93 10.05 295 543640 17143 79183310
Blood cholesterol increased 89.91 10.05 920 543015 82800 79117653
Shock 89.30 10.05 99 543836 43449 79157004
Disability assessment scale score increased 89.20 10.05 114 543821 3344 79197109
Gastrointestinal disorder 88.60 10.05 1246 542689 120959 79079494
Disseminated intravascular coagulation 88.22 10.05 69 543866 35773 79164680
Hyperhidrosis 86.38 10.05 641 543294 150851 79049602
Live birth 84.61 10.05 301 543634 18443 79182010
Bone erosion 84.36 10.05 291 543644 17556 79182897
Cholestasis 83.19 10.05 142 543793 51967 79148486
Heart rate decreased 81.47 10.05 785 543150 69531 79130922
Tenosynovitis 80.97 10.05 262 543673 15292 79185161
Drug ineffective 80.82 10.05 8483 535452 1072430 78128023
Juvenile idiopathic arthritis 80.00 10.05 128 543807 4635 79195818
Intentional product use issue 79.17 10.05 1468 542467 150644 79049809
Injection site reaction 78.64 10.05 641 543294 54144 79146309
Hyperkalaemia 78.37 10.05 458 543477 113940 79086513
Blood creatine phosphokinase increased 78.16 10.05 213 543722 65877 79134576
Joint range of motion decreased 77.57 10.05 439 543496 32843 79167610
Joint stiffness 76.49 10.05 509 543426 40321 79160132
Ventricular tachycardia 75.84 10.05 105 543830 41830 79158623
Injection site pruritus 73.79 10.05 518 543417 41765 79158688
Anaphylactic shock 73.62 10.05 82 543853 35914 79164539
Cognitive disorder 73.57 10.05 238 543697 69688 79130765
Sedation complication 73.20 10.05 10 543925 15659 79184794
Syncope 72.91 10.05 827 543108 178622 79021831
Palmar-plantar erythrodysaesthesia syndrome 72.82 10.05 71 543864 33063 79167390
Cerebral haemorrhage 72.70 10.05 180 543755 57493 79142960
Polyarthritis 72.29 10.05 215 543720 11987 79188466
Hepatocellular injury 71.21 10.05 135 543800 47458 79152995
Joint destruction 70.67 10.05 137 543798 5788 79194665
Encephalopathy 70.48 10.05 230 543705 67167 79133286
Neuroleptic malignant syndrome 70.47 10.05 51 543884 27508 79172945
Ventricular fibrillation 69.48 10.05 69 543866 31857 79168596
Cardiogenic shock 68.96 10.05 112 543823 41802 79158651
Loss of personal independence in daily activities 68.84 10.05 1032 542903 101548 79098905
Hypoxia 68.79 10.05 417 543518 102826 79097627
Basal cell carcinoma 68.26 10.05 463 543472 36912 79163541
Caesarean section 67.85 10.05 214 543721 12321 79188132
Neurotoxicity 67.70 10.05 73 543862 32445 79168008
Pulmonary fibrosis 67.07 10.05 523 543412 43589 79156864
Acute hepatic failure 65.63 10.05 65 543870 30048 79170405
Leukopenia 65.46 10.05 495 543440 116018 79084435
Localised infection 65.38 10.05 460 543475 37115 79163338
Injection site pain 65.13 10.05 1246 542689 128592 79071861
Seizure 64.47 10.05 903 543032 187931 79012522
Mobility decreased 63.88 10.05 1180 542755 120995 79079458
Drug withdrawal syndrome 63.72 10.05 86 543849 34632 79165821
Cardiac failure congestive 63.18 10.05 643 543292 141759 79058694
Hallucination 62.69 10.05 336 543599 85409 79115044
Vomiting 62.16 10.05 3814 540121 662014 78538439
Joint laxity 61.61 10.05 78 543857 2266 79198187
Anaemia 61.45 10.05 2447 541488 442568 78757885
Drug ineffective for unapproved indication 60.69 10.05 165 543770 51073 79149380
Myocardial infarction 59.88 10.05 889 543046 183240 79017213
Disturbance in attention 59.86 10.05 164 543771 50637 79149816
Agranulocytosis 59.57 10.05 137 543798 44893 79155560
Mydriasis 59.29 10.05 23 543912 17620 79182833
Hypothermia 58.28 10.05 42 543893 22704 79177749
Sepsis 58.13 10.05 1396 542539 268032 78932421
Tendonitis 57.98 10.05 318 543617 23512 79176941
Cytokine release syndrome 57.55 10.05 98 543837 35900 79164553
Nodule 57.40 10.05 309 543626 22685 79177768
Blood pressure increased 57.25 10.05 1866 542069 209494 78990959
Orthostatic hypotension 57.13 10.05 194 543741 55970 79144483
Gestational diabetes 56.98 10.05 130 543805 6163 79194290
Blood pressure diastolic increased 56.86 10.05 223 543712 14319 79186134
Neuropathy peripheral 56.68 10.05 653 543282 140652 79059801
Adverse event 56.43 10.05 644 543291 59570 79140883
Psychotic disorder 56.37 10.05 124 543811 41278 79159175
Disability 56.34 10.05 249 543686 16871 79183582
Venoocclusive liver disease 56.22 10.05 7 543928 11764 79188689
Immune reconstitution inflammatory syndrome 55.64 10.05 13 543922 13828 79186625
Myoclonus 55.49 10.05 64 543871 27596 79172857
Injection site swelling 55.49 10.05 528 543407 46604 79153849
Ascites 55.29 10.05 296 543639 75266 79125187
Neutrophil count decreased 55.26 10.05 394 543541 93565 79106888
Hypokalaemia 54.58 10.05 674 543261 143366 79057087
Type 2 diabetes mellitus 54.47 10.05 613 543322 56509 79143944
Cerebral infarction 54.16 10.05 147 543788 45529 79154924
Red blood cell sedimentation rate 53.80 10.05 118 543817 5447 79195006
Drug level increased 53.78 10.05 119 543816 39532 79160921
Tremor 53.65 10.05 826 543109 169257 79031196
Tongue disorder 53.59 10.05 213 543722 13762 79186691
Delirium 52.17 10.05 350 543585 84277 79116176
Abnormal behaviour 52.16 10.05 106 543829 36315 79164138
Ejection fraction decreased 51.80 10.05 98 543837 34479 79165974
Inappropriate antidiuretic hormone secretion 51.59 10.05 62 543873 26251 79174202
Pathogen resistance 51.08 10.05 17 543918 14325 79186128
Disorientation 51.04 10.05 237 543698 62539 79137914
Substance abuse 50.91 10.05 6 543929 10520 79189933
Restlessness 50.47 10.05 156 543779 46336 79154117
Alanine aminotransferase abnormal 50.42 10.05 154 543781 8713 79191740
Gamma-glutamyltransferase increased 50.26 10.05 197 543738 54483 79145970
Diabetic ketoacidosis 49.99 10.05 98 543837 34024 79166429
Body temperature decreased 49.91 10.05 383 543552 31762 79168691
Suicidal ideation 49.46 10.05 311 543624 76029 79124424
Respiratory distress 49.38 10.05 217 543718 58122 79142331
Extrapyramidal disorder 49.37 10.05 49 543886 22630 79177823
No adverse event 49.32 10.05 113 543822 37079 79163374
Miosis 49.20 10.05 23 543912 15766 79184687
Torsade de pointes 49.04 10.05 36 543899 19276 79181177
Creatinine renal clearance decreased 48.80 10.05 35 543900 18967 79181486
Oropharyngeal pain 48.70 10.05 1031 542904 108322 79092131
Femur fracture 48.52 10.05 439 543496 38213 79162240
Posterior reversible encephalopathy syndrome 48.33 10.05 65 543870 26216 79174237
Melaena 48.26 10.05 232 543703 60658 79139795
Dehydration 48.16 10.05 1306 542629 246881 78953572
Laryngitis 48.11 10.05 227 543708 15812 79184641
Injection site bruising 48.10 10.05 459 543476 40543 79159910
Second primary malignancy 47.74 10.05 19 543916 14331 79186122
Thrombotic microangiopathy 46.95 10.05 41 543894 20128 79180325
Blood creatinine increased 46.89 10.05 759 543176 154298 79046155
Akathisia 46.73 10.05 16 543919 13243 79187210
Ear infection 46.29 10.05 397 543538 34035 79166418
Proteinuria 46.21 10.05 95 543840 32407 79168046
Withdrawal syndrome 45.85 10.05 70 543865 26784 79173669
Aspergillus infection 45.76 10.05 38 543897 19123 79181330
Myalgia 45.40 10.05 943 542992 184698 79015755
Aggression 45.31 10.05 186 543749 50772 79149681
Eosinophilia 45.19 10.05 158 543777 45187 79155266
Asphyxia 45.19 10.05 12 543923 11708 79188745
Speech disorder 45.18 10.05 204 543731 54241 79146212
Synovial cyst 44.89 10.05 161 543774 9904 79190549
Rash maculo-papular 44.83 10.05 213 543722 55865 79144588
Haematotoxicity 44.78 10.05 25 543910 15494 79184959
Dyspnoea 44.50 10.05 5143 538792 851882 78348571
Exostosis 44.45 10.05 230 543705 16628 79183825
Tenderness 44.44 10.05 295 543640 23347 79177106
Latent tuberculosis 44.31 10.05 81 543854 3272 79197181
Bronchopulmonary aspergillosis 44.28 10.05 52 543883 22242 79178211
Drug use disorder 44.25 10.05 4 543931 8647 79191806
Bursitis 43.92 10.05 405 543530 35439 79165014
Acute respiratory distress syndrome 43.61 10.05 154 543781 43913 79156540
Blood glucose increased 43.55 10.05 538 543397 114437 79086016
Dystonia 43.49 10.05 49 543886 21350 79179103
Irritability 43.30 10.05 140 543795 41004 79159449
Wrong technique in product usage process 42.85 10.05 311 543624 73564 79126889
Loss of consciousness 42.58 10.05 848 543087 167095 79033358
Myelosuppression 42.49 10.05 137 543798 40159 79160294
Exposure to toxic agent 42.41 10.05 6 543929 9152 79191301
Transplant rejection 42.31 10.05 42 543893 19395 79181058
Brain oedema 42.04 10.05 67 543868 25196 79175257
Acute graft versus host disease 41.98 10.05 9 543926 10158 79190295
Blood parathyroid hormone decreased 41.55 10.05 162 543773 10374 79190079
Unintentional medical device removal 41.01 10.05 3 543932 7709 79192744
Osteonecrosis of jaw 40.84 10.05 154 543781 43072 79157381
Tuberculosis 40.52 10.05 208 543727 14990 79185463
Neck deformity 40.38 10.05 56 543879 1781 79198672
Fracture 40.36 10.05 271 543664 21530 79178923
Tumour lysis syndrome 40.30 10.05 63 543872 23876 79176577
Coagulopathy 39.67 10.05 120 543815 35886 79164567
Acute chest syndrome 39.54 10.05 51 543884 1510 79198943
Unresponsive to stimuli 39.46 10.05 221 543714 55567 79144886
Anaphylactic reaction 38.86 10.05 374 543561 83369 79117084
Vision blurred 38.81 10.05 499 543436 105399 79095054
Skin ulcer 38.77 10.05 551 543384 53599 79146854
Appendicolith 38.68 10.05 6 543929 8545 79191908
Granuloma skin 38.60 10.05 144 543791 9030 79191423
Atrial fibrillation 38.46 10.05 1041 542894 196845 79003608
Status epilepticus 38.37 10.05 70 543865 24971 79175482
Ankylosing spondylitis 38.27 10.05 175 543760 12030 79188423
Arrhythmia 37.97 10.05 253 543682 61019 79139434
Acute generalised exanthematous pustulosis 37.88 10.05 37 543898 17217 79183236
Neck mass 37.71 10.05 89 543846 4315 79196138
Facet joint syndrome 37.66 10.05 165 543770 11137 79189316
Therapeutic response decreased 37.52 10.05 653 543282 66200 79134253
Coronary artery disease 37.32 10.05 277 543658 65197 79135256
Psychomotor hyperactivity 37.15 10.05 36 543899 16813 79183640
Maternal exposure before pregnancy 37.04 10.05 88 543847 4285 79196168
Pre-eclampsia 37.01 10.05 119 543816 6922 79193531
Lip dry 37.01 10.05 205 543730 15213 79185240
Injection site rash 36.81 10.05 229 543706 17725 79182728
Accidental overdose 36.76 10.05 142 543793 39439 79161014
Peripheral venous disease 36.51 10.05 209 543726 15700 79184753
Joint injury 36.37 10.05 350 543585 30985 79169468
Wheelchair user 36.28 10.05 108 543827 6024 79194429
Haemophagocytic lymphohistiocytosis 36.25 10.05 58 543877 21779 79178674
Ischaemic stroke 36.08 10.05 111 543824 33020 79167433
Joint dislocation 35.95 10.05 218 543717 16721 79183732
BK virus infection 35.93 10.05 8 543927 8796 79191657
Multiple fractures 35.47 10.05 128 543807 7898 79192555
Clostridium difficile colitis 35.27 10.05 108 543827 32175 79168278
Erythema multiforme 35.24 10.05 41 543894 17610 79182843
Colorectal cancer 35.00 10.05 8 543927 8639 79191814
Hyperthermia 34.83 10.05 43 543892 17994 79182459
Mania 34.77 10.05 44 543891 18216 79182237
Spinal stenosis 34.65 10.05 205 543730 15586 79184867
Off label use 34.58 10.05 5549 538386 901666 78298787
Fear of injection 34.57 10.05 121 543814 7353 79193100
Tachypnoea 34.51 10.05 108 543827 31955 79168498
Smear cervix abnormal 34.45 10.05 62 543873 2474 79197979
Anxiety 34.34 10.05 1366 542569 247146 78953307
Pancreatitis acute 34.28 10.05 198 543737 49406 79151047
Gastroenteritis viral 34.27 10.05 288 543647 24543 79175910
Maternal exposure timing unspecified 34.26 10.05 102 543833 5690 79194763
Forced expiratory volume decreased 34.20 10.05 6 543929 7808 79192645
Panniculitis 34.17 10.05 171 543764 12200 79188253
Arthritis infective 34.11 10.05 129 543806 8142 79192311
Dysarthria 33.98 10.05 296 543639 67326 79133127
Bradyphrenia 33.93 10.05 15 543920 10625 79189828
Premature labour 33.90 10.05 130 543805 8260 79192193
Asthenia 33.55 10.05 3019 540916 508670 78691783
Limb deformity 33.44 10.05 75 543860 3515 79196938
Nausea 33.35 10.05 5884 538051 951312 78249141
Weight decreased 33.07 10.05 2833 541102 352365 78848088
Pulmonary oedema 33.03 10.05 414 543521 87840 79112613
Mental status changes 32.80 10.05 295 543640 66664 79133789
Toxic skin eruption 32.68 10.05 64 543871 22229 79178224
Bronchospasm 32.58 10.05 76 543859 24783 79175670
Ulcer 32.47 10.05 330 543605 29642 79170811
Premature rupture of membranes 32.45 10.05 80 543855 3989 79196464
Rotator cuff repair 32.44 10.05 51 543884 1819 79198634
Lupus-like syndrome 32.43 10.05 183 543752 13674 79186779
Stevens-Johnson syndrome 32.35 10.05 147 543788 39019 79161434
Asthma 32.21 10.05 689 543246 134406 79066047
Stress cardiomyopathy 32.20 10.05 18 543917 11148 79189305
Deep vein thrombosis postoperative 32.12 10.05 152 543783 10600 79189853
Graft versus host disease 32.10 10.05 33 543902 14993 79185460
Haemorrhage intracranial 32.04 10.05 83 543852 26110 79174343
Balance disorder 31.87 10.05 478 543457 98379 79102074
Dyskinesia 31.87 10.05 177 543758 44596 79155857
Toxic epidermal necrolysis 31.86 10.05 176 543759 44405 79156048
Premature delivery 31.77 10.05 271 543664 23196 79177257
Bone disorder 31.52 10.05 231 543704 18882 79181571
Platelet count decreased 31.40 10.05 1050 542885 193614 79006839
Chronic kidney disease 31.31 10.05 294 543641 65860 79134593
Retinitis 31.15 10.05 97 543838 5546 79194907
Blood bilirubin increased 31.06 10.05 295 543640 65937 79134516
Disease recurrence 31.05 10.05 175 543760 43934 79156519
Malignant mediastinal neoplasm 30.90 10.05 43 543892 1372 79199081
Wound infection 30.89 10.05 274 543661 23717 79176736
Anti-cyclic citrullinated peptide antibody 30.85 10.05 99 543836 5753 79194700
Face oedema 30.83 10.05 94 543841 28042 79172411
Adjustment disorder with depressed mood 30.54 10.05 133 543802 8953 79191500
Sciatica 30.53 10.05 354 543581 32868 79167585
Skin papilloma 30.50 10.05 99 543836 5787 79194666
Haemoptysis 30.46 10.05 240 543695 55759 79144694
Lymphocyte count decreased 30.45 10.05 193 543742 47096 79153357
Foot fracture 30.37 10.05 255 543680 21726 79178727
Cytopenia 30.33 10.05 58 543877 20325 79180128
Gastrointestinal haemorrhage 30.30 10.05 771 543164 146948 79053505
Blood calcium decreased 30.29 10.05 113 543822 31706 79168747
Interstitial lung disease 30.23 10.05 563 543372 112037 79088416
Scleritis 29.95 10.05 81 543854 4275 79196178
Shock haemorrhagic 29.92 10.05 57 543878 20003 79180450
Poor venous access 29.73 10.05 219 543716 17930 79182523
Influenza 29.54 10.05 1122 542813 128484 79071969
Herpes zoster 29.52 10.05 838 543097 92245 79108208
Drug tolerance decreased 29.46 10.05 170 543765 12808 79187645
Angina pectoris 29.42 10.05 219 543716 51513 79148940
Hallucination, visual 29.39 10.05 119 543816 32610 79167843
Skin cancer 29.08 10.05 189 543746 14851 79185602
Pyrexia 29.01 10.05 4123 539812 674586 78525867
Fear 28.99 10.05 67 543868 21919 79178534
Hallucination, auditory 28.98 10.05 61 543874 20632 79179821
Jaundice 28.85 10.05 229 543706 53120 79147333
Blood alkaline phosphatase increased 28.83 10.05 286 543649 63378 79137075
Cytomegalovirus viraemia 28.72 10.05 27 543908 12794 79187659
Acute myeloid leukaemia 28.55 10.05 111 543824 30774 79169679
Adenovirus infection 28.40 10.05 11 543924 8436 79192017
Urinary retention 28.40 10.05 248 543687 56382 79144071
Anuria 28.36 10.05 63 543872 20900 79179553
Tenosynovitis stenosans 28.33 10.05 64 543871 3014 79197439
Hepatitis B reactivation 28.29 10.05 4 543931 6104 79194349
Pulmonary alveolar haemorrhage 28.27 10.05 22 543913 11435 79189018
Leukocytosis 28.16 10.05 177 543758 43278 79157175
Emotional distress 27.91 10.05 159 543776 39810 79160643
Acidosis 27.89 10.05 58 543877 19704 79180749
Pneumatosis intestinalis 27.80 10.05 5 543930 6392 79194061
Dislocation of vertebra 27.76 10.05 117 543818 7763 79192690
Colitis ulcerative 27.52 10.05 360 543575 34382 79166071
Synovial fluid analysis 27.47 10.05 54 543881 2305 79198148
Obesity 27.42 10.05 363 543572 34762 79165691
Hemiplegia 27.42 10.05 37 543898 14902 79185551
Acute graft versus host disease in skin 27.41 10.05 9 543926 7649 79192804
Cerebrovascular accident 27.36 10.05 828 543107 154464 79045989
Diarrhoea 27.33 10.05 5445 538490 875044 78325409
Product quality issue 27.08 10.05 129 543806 33811 79166642
Pulmonary embolism 26.96 10.05 929 543006 170725 79029728
Hypertransaminasaemia 26.84 10.05 25 543910 11899 79188554
Chest discomfort 26.60 10.05 727 543208 137317 79063136
Septic shock 26.53 10.05 636 543299 122165 79078288
Aphasia 26.49 10.05 198 543737 46534 79153919
Metastases to bone 26.49 10.05 82 543853 24345 79176108
Hypomagnesaemia 26.48 10.05 199 543736 46712 79153741
Mouth ulceration 26.42 10.05 388 543547 38006 79162447
Rheumatoid lung 26.30 10.05 76 543859 4169 79196284
Sexual dysfunction 26.29 10.05 10 543925 7753 79192700
Sinus tachycardia 26.22 10.05 146 543789 36762 79163691
Metastases to liver 26.02 10.05 102 543833 28212 79172241
Subdural haematoma 25.95 10.05 118 543817 31316 79169137
Muscle rigidity 25.88 10.05 61 543874 19821 79180632
Bronchitis 25.85 10.05 1114 542821 129530 79070923
Nocardiosis 25.66 10.05 4 543931 5675 79194778
Polyneuropathy 25.54 10.05 82 543853 24069 79176384
Antinuclear antibody positive 25.39 10.05 114 543821 7776 79192677
Blood pressure decreased 25.27 10.05 502 543433 98964 79101489
Liver injury 25.27 10.05 534 543401 56080 79144373
Electrocardiogram QRS complex prolonged 25.24 10.05 22 543913 10811 79189642
Dysphagia 25.17 10.05 637 543298 121499 79078954
Labelled drug-drug interaction medication error 25.16 10.05 100 543835 27550 79172903
Multiple sclerosis relapse 25.04 10.05 200 543735 46333 79154120
Accidental exposure to product 25.02 10.05 119 543816 31203 79169250
Acute myocardial infarction 25.00 10.05 372 543563 76664 79123789
Haemorrhage 24.96 10.05 454 543481 90664 79109789
Klebsiella infection 24.94 10.05 43 543892 15677 79184776
Muscle twitching 24.87 10.05 86 543849 24678 79175775
Loose body in joint 24.83 10.05 37 543898 1258 79199195
Malignant melanoma 24.79 10.05 179 543756 14562 79185891
Cystitis haemorrhagic 24.75 10.05 16 543919 9156 79191297
Device difficult to use 24.72 10.05 33 543902 13352 79187101
Hyperbilirubinaemia 24.72 10.05 85 543850 24433 79176020
Immunodeficiency 24.70 10.05 242 543693 21526 79178927
Temperature regulation disorder 24.54 10.05 5 543930 5848 79194605
White blood cell count decreased 24.50 10.05 1042 542893 187246 79013207
Rhinorrhoea 24.43 10.05 686 543249 75388 79125065
Glycosylated haemoglobin increased 24.36 10.05 60 543875 19200 79181253
Fracture delayed union 24.21 10.05 48 543887 2062 79198391
Hemiparesis 24.20 10.05 133 543802 33600 79166853
Hyperuricaemia 23.99 10.05 27 543908 11772 79188681
Hepatotoxicity 23.96 10.05 229 543706 51123 79149330
Injection site warmth 23.87 10.05 178 543757 14629 79185824
Synovial disorder 23.83 10.05 46 543889 1937 79198516
Cyst 23.82 10.05 169 543766 13671 79186782
Breast cancer stage I 23.76 10.05 8 543927 6692 79193761
Ileus 23.72 10.05 95 543840 26116 79174337
Product administration error 23.71 10.05 124 543811 31722 79168731
Pancytopenia 23.60 10.05 1369 542566 164376 79036077
Joint noise 23.52 10.05 70 543865 3904 79196549
Myocardial ischaemia 23.41 10.05 92 543843 25427 79175026
Rebound effect 23.34 10.05 10 543925 7216 79193237
Finger deformity 23.31 10.05 107 543828 7367 79193086
Pulmonary arterial hypertension 23.11 10.05 107 543828 28259 79172194
Hyperlactacidaemia 23.00 10.05 5 543930 5590 79194863
Diabetes insipidus 22.97 10.05 4 543931 5233 79195220
Cyanosis 22.96 10.05 91 543844 25091 79175362
Cardiotoxicity 22.78 10.05 30 543905 12209 79188244
Device use error 22.66 10.05 10 543925 7091 79193362
Pancreatitis 22.65 10.05 330 543605 68245 79132208
Nephropathy toxic 22.53 10.05 68 543867 20351 79180102
Chronic graft versus host disease 22.52 10.05 9 543926 6772 79193681
Hepatitis acute 22.46 10.05 45 543890 15497 79184956
Infective pulmonary exacerbation of cystic fibrosis 22.42 10.05 33 543902 12818 79187635
Pleuritic pain 22.41 10.05 132 543803 10020 79190433
Oral herpes 22.39 10.05 286 543649 27168 79173285
Cardiac failure acute 22.38 10.05 61 543874 18868 79181585
Hydrops foetalis 22.23 10.05 27 543908 751 79199702
Peripheral sensory neuropathy 22.22 10.05 34 543901 12999 79187454
Febrile bone marrow aplasia 22.17 10.05 34 543901 12986 79187467
Tubulointerstitial nephritis 22.15 10.05 161 543774 38074 79162379
Product prescribing error 22.14 10.05 197 543738 44616 79155837
Frequent bowel movements 22.12 10.05 303 543632 29236 79171217
Oliguria 22.07 10.05 49 543886 16260 79184193
Compartment syndrome 22.03 10.05 4 543931 5078 79195375
Blood lactic acid increased 21.97 10.05 33 543902 12711 79187742
Hyperprolactinaemia 21.80 10.05 3 543932 4673 79195780
Affective disorder 21.79 10.05 15 543920 8304 79192149
Haematocrit decreased 21.72 10.05 560 543375 60752 79139701
Potentiating drug interaction 21.67 10.05 17 543918 8802 79191651
Purpura 21.57 10.05 65 543870 19462 79180991
Ultrasound antenatal screen 21.37 10.05 25 543910 668 79199785
Dermatitis acneiform 21.29 10.05 22 543913 9971 79190482
Acute respiratory failure 21.28 10.05 282 543653 59259 79141194
Vertigo 21.26 10.05 337 543598 68745 79131708
Polyuria 21.24 10.05 44 543891 14970 79185483
Cleft lip and palate 21.22 10.05 25 543910 673 79199780
Lower limb fracture 21.17 10.05 247 543688 22968 79177485
Venoocclusive disease 21.17 10.05 3 543932 4570 79195883
Hyperthyroidism 21.06 10.05 79 543856 22130 79178323
Cardiac failure chronic 21.03 10.05 27 543908 11108 79189345
Decreased appetite 21.02 10.05 2030 541905 340388 78860065
Haematoma 21.00 10.05 241 543694 51954 79148499
Hepatic encephalopathy 20.99 10.05 89 543846 24077 79176376
Hepatitis cholestatic 20.98 10.05 39 543896 13813 79186640
Oxygen saturation decreased 20.96 10.05 1079 542856 127968 79072485
Human antichimeric antibody positive 20.88 10.05 39 543896 1602 79198851
Haemoglobin decreased 20.87 10.05 1773 542162 220346 78980107
Acute coronary syndrome 20.81 10.05 74 543861 21059 79179394
Hypophosphataemia 20.78 10.05 68 543867 19845 79180608
Hypernatraemia 20.74 10.05 42 543893 14409 79186044
Metastases to central nervous system 20.72 10.05 51 543884 16324 79184129
Pseudomonas infection 20.72 10.05 73 543862 20830 79179623
Epstein-Barr virus infection 20.61 10.05 42 543893 14374 79186079
Haemodynamic instability 20.56 10.05 56 543879 17326 79183127
Respiratory disorder 20.52 10.05 201 543734 44655 79155798
Multiple-drug resistance 20.39 10.05 18 543917 8790 79191663
Respiratory acidosis 20.29 10.05 28 543907 11172 79189281
Graft versus host disease in skin 20.27 10.05 8 543927 6065 79194388
Post procedural infection 20.17 10.05 140 543795 11244 79189209
Sinus bradycardia 20.12 10.05 96 543839 25151 79175302
Pulmonary haemorrhage 20.10 10.05 44 543891 14673 79185780
Glomerular filtration rate decreased 20.10 10.05 83 543852 22619 79177834
Urticaria 20.09 10.05 1045 542890 184156 79016297
Mental disorder 20.03 10.05 128 543807 31174 79169279
Ingrown hair 20.02 10.05 25 543910 716 79199737
Autoimmune disorder 20.00 10.05 187 543748 16425 79184028
Anhedonia 19.97 10.05 45 543890 14853 79185600
Injury 19.89 10.05 680 543255 76816 79123637
Postoperative wound infection 19.88 10.05 154 543781 12807 79187646
Hyperammonaemia 19.83 10.05 28 543907 11065 79189388
Jaundice cholestatic 19.66 10.05 29 543906 11255 79189198
Pulseless electrical activity 19.61 10.05 42 543893 14118 79186335
Bacteraemia 19.61 10.05 137 543798 32687 79167766
Tardive dyskinesia 19.59 10.05 26 543909 10545 79189908
Lymphopenia 19.53 10.05 125 543810 30432 79170021
Pleural effusion 19.51 10.05 801 543134 144461 79055992
Bladder cancer 19.48 10.05 68 543867 19458 79180995
Heart rate irregular 19.35 10.05 322 543613 32357 79168096
Injection site haemorrhage 19.32 10.05 282 543653 27588 79172865
Enterocolitis 19.31 10.05 44 543891 14468 79185985
Drug tolerance 19.28 10.05 113 543822 8562 79191891
Lip swelling 19.28 10.05 182 543753 40729 79159724
Cardiomyopathy 19.27 10.05 116 543819 28658 79171795
Body height below normal 19.25 10.05 43 543892 2010 79198443
Parkinsonism 19.19 10.05 54 543881 16530 79183923
Therapy partial responder 19.15 10.05 58 543877 17339 79183114
Hepatitis fulminant 19.15 10.05 13 543922 7249 79193204
Ankle arthroplasty 19.10 10.05 36 543899 1489 79198964
Endophthalmitis 19.07 10.05 10 543925 6418 79194035
Catatonia 18.97 10.05 19 543916 8737 79191716
Transplant dysfunction 18.94 10.05 13 543922 7208 79193245
Eosinophil count increased 18.85 10.05 57 543878 17048 79183405
Trisomy 18 18.83 10.05 22 543913 587 79199866
Virologic failure 18.82 10.05 3 543932 4188 79196265
Cytomegalovirus infection reactivation 18.78 10.05 19 543916 8697 79191756
Cytomegalovirus chorioretinitis 18.71 10.05 7 543928 5483 79194970
Foot operation 18.57 10.05 83 543852 5650 79194803
Atrial tachycardia 18.50 10.05 13 543922 7120 79193333
Pruritus genital 18.46 10.05 4 543931 4482 79195971
Cushingoid 18.45 10.05 120 543815 9432 79191021
Polyhydramnios 18.39 10.05 38 543897 1682 79198771
Surgery 18.36 10.05 320 543615 32446 79168007
Atrioventricular block 18.34 10.05 43 543892 13998 79186455
Sleep terror 18.30 10.05 4 543931 4454 79195999
Myocarditis 18.29 10.05 81 543854 21652 79178801
Flushing 18.28 10.05 460 543475 87808 79112645
Ventricular arrhythmia 18.23 10.05 20 543915 8820 79191633
Multiple drug therapy 18.14 10.05 3 543932 4075 79196378
Skin necrosis 18.11 10.05 196 543739 17891 79182562
Hypocalcaemia 18.01 10.05 236 543699 49688 79150765
Onychomycosis 17.97 10.05 107 543828 8154 79192299
Hepatocellular carcinoma 17.96 10.05 21 543914 9000 79191453
Osteopenia 17.92 10.05 198 543737 18166 79182287
Delusion 17.87 10.05 75 543860 20348 79180105
Personality change 17.86 10.05 26 543909 10144 79190309
Progressive multifocal leukoencephalopathy 17.81 10.05 76 543859 20524 79179929
Pulmonary congestion 17.76 10.05 110 543825 26990 79173463
Heparin-induced thrombocytopenia 17.75 10.05 24 543911 9658 79190795
Musculoskeletal disorder 17.73 10.05 224 543711 21224 79179229
Breast feeding 17.63 10.05 23 543912 689 79199764
Cholangitis 17.61 10.05 38 543897 12738 79187715
Hypoalbuminaemia 17.55 10.05 80 543855 21217 79179236
Rash pruritic 17.50 10.05 625 543310 71004 79129449
Short stature 17.50 10.05 23 543912 694 79199759
Obstructive airways disorder 17.49 10.05 134 543801 31325 79169128
Immune effector cell-associated neurotoxicity syndrome 17.49 10.05 9 543926 5839 79194614
Bone pain 17.46 10.05 271 543664 55471 79144982
Haematemesis 17.44 10.05 251 543684 52013 79148440
Maternal exposure during breast feeding 17.39 10.05 50 543885 2735 79197718
Hypothyroidism 17.34 10.05 252 543683 52140 79148313
Accidental death 17.31 10.05 4 543931 4287 79196166
Foetal distress syndrome 17.30 10.05 19 543916 473 79199980
Subarachnoid haemorrhage 17.25 10.05 97 543838 24368 79176085
Palpitations 17.24 10.05 697 543238 125913 79074540
Paranoia 17.23 10.05 71 543864 19361 79181092
Prescribed overdose 17.13 10.05 358 543577 37525 79162928
Dizziness 17.12 10.05 3247 540688 523194 78677259
Upper respiratory tract infection 17.06 10.05 773 543162 90395 79110058
COVID-19 17.04 10.05 890 543045 156784 79043669
Left ventricular dysfunction 17.00 10.05 71 543864 19290 79181163
Oesophageal carcinoma 16.97 10.05 31 543904 11053 79189400
Placental disorder 16.96 10.05 26 543909 907 79199546
Normal newborn 16.95 10.05 94 543841 6978 79193475
Device leakage 16.95 10.05 30 543905 10826 79189627
COVID-19 pneumonia 16.94 10.05 121 543814 28728 79171725
Nightmare 16.93 10.05 105 543830 25756 79174697
Nasal polyps 16.93 10.05 15 543920 7312 79193141
Hypoxic-ischaemic encephalopathy 16.90 10.05 17 543918 7803 79192650
Endodontic procedure 16.89 10.05 49 543886 2694 79197759
Renal injury 16.85 10.05 59 543876 16868 79183585
Pharyngitis streptococcal 16.82 10.05 128 543807 10586 79189867
Gastric haemorrhage 16.69 10.05 50 543885 15000 79185453
Toxic encephalopathy 16.63 10.05 33 543902 11407 79189046
Hepatic cancer 16.52 10.05 29 543906 10500 79189953
Ileus paralytic 16.50 10.05 25 543910 9595 79190858
Aspartate aminotransferase increased 16.45 10.05 775 543160 137866 79062587
Generalised tonic-clonic seizure 16.42 10.05 206 543729 43704 79156749
Device related infection 16.40 10.05 152 543783 34142 79166311
Red blood cell count decreased 16.39 10.05 511 543424 57002 79143451
Deformity 16.37 10.05 117 543818 9488 79190965
Antibody test positive 16.35 10.05 49 543886 2743 79197710
Metastases to lung 16.33 10.05 66 543869 18097 79182356
End stage renal disease 16.30 10.05 37 543898 12183 79188270
Therapy non-responder 16.28 10.05 778 543157 91527 79108926
Injection site urticaria 16.26 10.05 146 543789 12680 79187773
Hepatic cirrhosis 16.15 10.05 331 543604 34575 79165878
Knee operation 16.14 10.05 81 543854 5785 79194668
Radiation inflammation 16.14 10.05 25 543910 880 79199573
General physical health deterioration 15.96 10.05 2127 541808 273111 78927342
Paralysis 15.93 10.05 42 543893 13135 79187318
Cross sensitivity reaction 15.92 10.05 3 543932 3709 79196744
Polydipsia 15.90 10.05 13 543922 6592 79193861
Disturbance in social behaviour 15.86 10.05 7 543928 4963 79195490
International normalised ratio increased 15.85 10.05 448 543487 84273 79116180
Toothache 15.85 10.05 207 543728 19763 79180690
Pneumonia aspiration 15.82 10.05 342 543593 66625 79133828
Atrioventricular block complete 15.80 10.05 59 543876 16551 79183902
Intervertebral disc degeneration 15.78 10.05 171 543764 15614 79184839
Sickle cell anaemia 15.74 10.05 21 543914 643 79199810
Bradypnoea 15.73 10.05 11 543924 6041 79194412
Tooth disorder 15.72 10.05 259 543676 25974 79174479
Diaphragmatic disorder 15.68 10.05 36 543899 1714 79198739
Respiration abnormal 15.64 10.05 18 543917 7770 79192683
Induced labour 15.43 10.05 24 543911 848 79199605
Transaminases increased 15.39 10.05 254 543681 51489 79148964
Hydrocephalus 15.39 10.05 23 543912 8877 79191576
Bone cyst 15.38 10.05 55 543880 3378 79197075
Erectile dysfunction 15.36 10.05 50 543885 14614 79185839
Alcohol interaction 15.34 10.05 7 543928 4867 79195586
Acute pulmonary oedema 15.27 10.05 48 543887 14182 79186271
Schizophrenia 15.25 10.05 54 543881 15386 79185067
Fluid retention 15.22 10.05 361 543574 69448 79131005
Incoherent 15.21 10.05 18 543917 7674 79192779
Lacrimal disorder 15.09 10.05 18 543917 491 79199962
Right ventricular failure 15.07 10.05 96 543839 23401 79177052
Strongyloidiasis 15.01 10.05 4 543931 3894 79196559
Type 1 diabetes mellitus 15.00 10.05 15 543920 6904 79193549
Cellulitis 14.98 10.05 898 543037 108162 79092291
Lymph gland infection 14.95 10.05 19 543916 554 79199899
Spinal osteoarthritis 14.95 10.05 179 543756 16748 79183705
Stillbirth 14.94 10.05 60 543875 3895 79196558
Blood lactate dehydrogenase increased 14.93 10.05 183 543752 38987 79161466
Device expulsion 14.93 10.05 109 543826 25752 79174701
Rhinitis allergic 14.91 10.05 39 543896 12230 79188223
Amylase increased 14.91 10.05 34 543901 11175 79189278
Coordination abnormal 14.89 10.05 64 543871 17248 79183205
Dactylitis 14.86 10.05 47 543888 2710 79197743
Skin toxicity 14.85 10.05 21 543914 8293 79192160
Tuberculin test positive 14.76 10.05 54 543881 3354 79197099
Depressed mood 14.75 10.05 237 543698 48243 79152210
Joint lock 14.73 10.05 52 543883 3173 79197280
Aplasia 14.73 10.05 19 543916 7801 79192652
Hyperpyrexia 14.65 10.05 12 543923 6080 79194373
Hypoaesthesia 14.61 10.05 1417 542518 177935 79022518
Hyperlipidaemia 14.58 10.05 111 543824 25982 79174471
Product administered to patient of inappropriate age 14.56 10.05 10 543925 5543 79194910
Salivary hypersecretion 14.55 10.05 49 543886 14175 79186278
Pneumonia bacterial 14.54 10.05 75 543860 19256 79181197
Acute lymphocytic leukaemia recurrent 14.54 10.05 7 543928 4717 79195736
Drug screen positive 14.51 10.05 12 543923 6051 79194402
Coronary artery bypass 14.50 10.05 12 543923 6050 79194403
Dry eye 14.48 10.05 342 543593 36589 79163864
Renal disorder 14.47 10.05 201 543734 41904 79158549
Tooth infection 14.44 10.05 194 543741 18638 79181815
Anal fissure 14.41 10.05 96 543839 7607 79192846
Dysgeusia 14.39 10.05 289 543646 56888 79143565
Bronchial secretion retention 14.38 10.05 5 543930 4099 79196354
Blood urea increased 14.35 10.05 240 543695 48550 79151903
Injection site extravasation 14.34 10.05 114 543821 9555 79190898
Pulmonary hypertension 14.31 10.05 236 543699 47844 79152609
Osteoporotic fracture 14.20 10.05 62 543873 4178 79196275
Bone marrow failure 14.19 10.05 254 543681 50853 79149600
Depression 14.18 10.05 1279 542656 215511 78984942
Walking aid user 14.16 10.05 118 543817 10030 79190423
Wound infection pseudomonas 14.14 10.05 33 543902 1588 79198865
Renal tubular disorder 14.13 10.05 14 543921 6472 79193981
Lipase increased 14.08 10.05 61 543874 16405 79184048
Lymphatic fistula 14.07 10.05 22 543913 781 79199672
Ligament rupture 14.05 10.05 53 543882 3341 79197112
Anti-neutrophil cytoplasmic antibody positive vasculitis 14.04 10.05 4 543931 3725 79196728
Persecutory delusion 14.03 10.05 8 543927 4901 79195552
Acute graft versus host disease in intestine 14.03 10.05 5 543930 4036 79196417
Clear cell renal cell carcinoma 13.96 10.05 44 543891 2532 79197921
Acute myeloid leukaemia recurrent 13.96 10.05 3 543932 3380 79197073
C-reactive protein decreased 13.94 10.05 45 543890 2623 79197830
Haematuria 13.92 10.05 360 543575 68476 79131977
Intracranial pressure increased 13.91 10.05 22 543913 8300 79192153
Foetal exposure during pregnancy 13.91 10.05 77 543858 5713 79194740
Immunosuppression 13.88 10.05 141 543794 12662 79187791
C-reactive protein 13.88 10.05 69 543866 4910 79195543
Lower respiratory tract congestion 13.81 10.05 59 543876 3938 79196515
Laryngospasm 13.78 10.05 5 543930 3992 79196461
Personality disorder 13.70 10.05 13 543922 6133 79194320
Bone density abnormal 13.69 10.05 49 543886 3011 79197442
Kidney transplant rejection 13.69 10.05 31 543904 10215 79190238
Haemorrhage in pregnancy 13.69 10.05 30 543905 1384 79199069
Generalised oedema 13.65 10.05 100 543835 23609 79176844
Alcohol abuse 13.61 10.05 10 543925 5353 79195100
Kidney infection 13.57 10.05 217 543718 21634 79178819
Pemphigoid 13.55 10.05 56 543879 15259 79185194
Hypomania 13.53 10.05 19 543916 7525 79192928
Skin exfoliation 13.42 10.05 280 543655 54820 79145633
Prostatic specific antigen increased 13.41 10.05 32 543903 10354 79190099
Sleep disorder due to a general medical condition 13.40 10.05 51 543884 14226 79186227
Capillary leak syndrome 13.38 10.05 5 543930 3920 79196533
Anticholinergic syndrome 13.36 10.05 4 543931 3607 79196846
Femoral hernia incarcerated 13.29 10.05 22 543913 820 79199633
Blood phosphorus increased 13.27 10.05 32 543903 10315 79190138
Circulatory collapse 13.24 10.05 179 543756 37489 79162964
Diabetes mellitus inadequate control 13.19 10.05 104 543831 24160 79176293
Hypertonia 13.18 10.05 18 543917 7214 79193239
Immunosuppressant drug level increased 13.16 10.05 26 543909 9001 79191452
Dry skin 13.12 10.05 358 543577 67637 79132816
Visual acuity reduced 13.08 10.05 133 543802 29336 79171117
Drug abuser 13.08 10.05 13 543922 6000 79194453
Diabetes mellitus 13.06 10.05 421 543514 77969 79122484
Drug dose omission by device 13.04 10.05 14 543921 6236 79194217
Joint warmth 13.03 10.05 32 543903 1592 79198861
Incorrect route of product administration 13.01 10.05 164 543771 34765 79165688
Cervical incompetence 13.01 10.05 17 543918 510 79199943
Lip blister 12.98 10.05 45 543890 2722 79197731
Brain injury 12.96 10.05 38 543897 11479 79188974
Breast abscess 12.96 10.05 30 543905 1436 79199017
Aphthous ulcer 12.96 10.05 174 543761 16715 79183738
Hypertriglyceridaemia 12.96 10.05 44 543891 12696 79187757
Oligoarthritis 12.91 10.05 20 543915 704 79199749
Adverse drug reaction 12.87 10.05 565 543370 65827 79134626
Type I hypersensitivity 12.81 10.05 7 543928 4391 79196062
Appendicitis 12.81 10.05 86 543849 20708 79179745
Blood folate increased 12.78 10.05 17 543918 519 79199934
Systemic inflammatory response syndrome 12.78 10.05 38 543897 11427 79189026
Small for dates baby 12.77 10.05 16 543919 460 79199993
Bradykinesia 12.76 10.05 22 543913 8021 79192432
Intestinal ischaemia 12.71 10.05 47 543888 13223 79187230
Pharyngitis 12.71 10.05 219 543716 22156 79178297
Anger 12.68 10.05 67 543868 17095 79183358
Metastasis 12.67 10.05 17 543918 6863 79193590
Dyslipidaemia 12.65 10.05 39 543896 11594 79188859
Arthropod bite 12.63 10.05 100 543835 8371 79192082
Pain in jaw 12.62 10.05 230 543705 45921 79154532
Human anti-human antibody test 12.61 10.05 15 543920 408 79200045
Spinal disorder 12.60 10.05 116 543819 10144 79190309
Peritoneal dialysis complication 12.57 10.05 40 543895 2314 79198139
Cyst rupture 12.56 10.05 19 543916 655 79199798
Abortion threatened 12.56 10.05 15 543920 410 79200043
Drug specific antibody 12.55 10.05 43 543892 2585 79197868
Joint ankylosis 12.52 10.05 38 543897 2142 79198311
Complications of transplanted kidney 12.48 10.05 15 543920 6351 79194102
Congestive cardiomyopathy 12.45 10.05 40 543895 11740 79188713
Feeling abnormal 12.42 10.05 926 543009 158273 79042180
Hepatitis E antibody positive 12.41 10.05 12 543923 256 79200197
Renal tubular necrosis 12.40 10.05 110 543825 24929 79175524
Human herpesvirus 6 infection 12.40 10.05 11 543924 5359 79195094
Pulmonary tuberculosis 12.37 10.05 94 543841 7771 79192682
Mitochondrial toxicity 12.37 10.05 3 543932 3111 79197342
Acute lung injury 12.29 10.05 3 543932 3097 79197356
Vascular purpura 12.28 10.05 3 543932 3095 79197358
Placental insufficiency 12.23 10.05 25 543910 1098 79199355
Palmoplantar keratoderma 12.23 10.05 5 543930 3711 79196742
Threatened labour 12.21 10.05 18 543917 606 79199847
Road traffic accident 12.19 10.05 387 543548 43277 79157176
Hypoventilation 12.17 10.05 19 543916 7205 79193248
Myofascial pain syndrome 12.17 10.05 36 543899 2001 79198452
Muscle spasticity 12.16 10.05 91 543844 21384 79179069
Alanine aminotransferase increased 12.15 10.05 949 542986 161621 79038832
Nail injury 12.12 10.05 18 543917 610 79199843
Coronary arterial stent insertion 12.11 10.05 14 543921 6030 79194423
Spondylitis 12.10 10.05 64 543871 4667 79195786
Abortion incomplete 12.08 10.05 3 543932 3061 79197392
Anal fistula 12.07 10.05 85 543850 6859 79193594
Hypercholesterolaemia 12.04 10.05 223 543712 22872 79177581
Tooth fracture 12.04 10.05 126 543809 11404 79189049
Tooth abscess 12.03 10.05 166 543769 16044 79184409
Carotid artery thrombosis 12.01 10.05 3 543932 3050 79197403
Psychiatric decompensation 12 10.05 6 543929 3957 79196496
Sudden death 12.00 10.05 97 543838 22414 79178039
Defaecation disorder 12.00 10.05 19 543916 682 79199771
Ketoacidosis 11.99 10.05 22 543913 7832 79192621
Gestational hypertension 11.99 10.05 34 543901 1845 79198608
Hypercapnia 11.97 10.05 27 543908 8908 79191545
Neck pain 11.92 10.05 629 543306 74788 79125665
Oesophageal fibrosis 11.92 10.05 10 543925 176 79200277
Candida infection 11.90 10.05 186 543749 38028 79162425
Gastric cancer 11.89 10.05 33 543902 10146 79190307
Respiratory tract infection viral 11.85 10.05 59 543876 4200 79196253
Pulmonary pain 11.77 10.05 61 543874 4412 79196041
Sinus congestion 11.76 10.05 196 543739 19700 79180753
Myopathy 11.71 10.05 87 543848 20476 79179977
Rash erythematous 11.71 10.05 302 543633 57467 79142986
Pneumothorax 11.70 10.05 130 543805 28193 79172260
Troponin increased 11.68 10.05 80 543855 19175 79181278
Sensitisation 11.66 10.05 4 543931 3307 79197146
Bacterial sepsis 11.62 10.05 24 543911 8174 79192279
Complication of device removal 11.61 10.05 6 543929 3883 79196570
Metastases to meninges 11.60 10.05 5 543930 3596 79196857
Hepatitis C 11.58 10.05 42 543893 11883 79188570
Neutrophilia 11.51 10.05 23 543912 7928 79192525
Iodine allergy 11.50 10.05 17 543918 574 79199879
Pulmonary function test abnormal 11.50 10.05 7 543928 4137 79196316
Diplopia 11.42 10.05 160 543775 33306 79167147
Presyncope 11.41 10.05 204 543731 40850 79159603
Angina unstable 11.40 10.05 66 543869 16461 79183992
Ischaemic cardiomyopathy 11.36 10.05 22 543913 7673 79192780
Nephrolithiasis 11.35 10.05 458 543477 52833 79147620
Hepatitis B 11.30 10.05 25 543910 8307 79192146
Skin laceration 11.29 10.05 268 543667 28694 79171759
Inadequate analgesia 11.28 10.05 9 543926 4620 79195833
Accidental exposure to product by child 11.27 10.05 3 543932 2923 79197530
Benign ovarian tumour 11.27 10.05 13 543922 342 79200111
Pseudomembranous colitis 11.26 10.05 12 543923 5362 79195091
Epstein-Barr virus associated lymphoproliferative disorder 11.23 10.05 5 543930 3527 79196926
Lethargy 11.18 10.05 447 543488 80845 79119608
Neurologic neglect syndrome 11.16 10.05 3 543932 2904 79197549
Steroid diabetes 11.09 10.05 5 543930 3501 79196952
Colitis microscopic 11.08 10.05 37 543898 10731 79189722
Drug hypersensitivity 11.02 10.05 1831 542104 297085 78903368
Skin neoplasm excision 11.00 10.05 23 543912 1027 79199426
Extradural haematoma 10.98 10.05 3 543932 2873 79197580
Deep vein thrombosis 10.98 10.05 694 543241 120225 79080228
Arthritis bacterial 10.94 10.05 103 543832 9063 79191390
Bone density increased 10.92 10.05 20 543915 809 79199644
Cartilage injury 10.92 10.05 29 543906 1514 79198939
Ventricular hypokinesia 10.90 10.05 30 543905 9249 79191204
Vascular device infection 10.79 10.05 35 543900 10241 79190212
Pancreatic steatosis 10.75 10.05 24 543911 1121 79199332
Skin ulcer haemorrhage 10.74 10.05 16 543919 544 79199909
Hand fracture 10.71 10.05 76 543859 6149 79194304
Cholestasis of pregnancy 10.69 10.05 22 543913 971 79199482
Mass 10.65 10.05 173 543762 17299 79183154
Psychomotor skills impaired 10.63 10.05 12 543923 5225 79195228
Nerve compression 10.62 10.05 103 543832 9136 79191317
Neutropenic colitis 10.61 10.05 14 543921 5693 79194760
Euglycaemic diabetic ketoacidosis 10.60 10.05 19 543916 6825 79193628
Gait inability 10.47 10.05 497 543438 58420 79142033
Panic attack 10.46 10.05 110 543825 24106 79176347
Ventricular extrasystoles 10.46 10.05 85 543850 19619 79180834
Intestinal stenosis 10.44 10.05 52 543883 3702 79196751
Hernia 10.44 10.05 169 543766 16890 79183563
Chest pain 10.43 10.05 1729 542206 280575 78919878
Vacuum extractor delivery 10.43 10.05 8 543927 123 79200330
Nephrotic syndrome 10.43 10.05 40 543895 11134 79189319
Foetal death 10.42 10.05 92 543843 7952 79192501
Cogwheel rigidity 10.42 10.05 4 543931 3084 79197369
Electrolyte imbalance 10.41 10.05 148 543787 30733 79169720
Cell death 10.41 10.05 10 543925 4689 79195764
Lung opacity 10.35 10.05 12 543923 5162 79195291
Amyloid arthropathy 10.31 10.05 16 543919 564 79199889
Product monitoring error 10.31 10.05 29 543906 8877 79191576
Prescribed underdose 10.29 10.05 269 543666 29245 79171208
Vascular rupture 10.28 10.05 30 543905 1655 79198798
Dyspnoea exertional 10.27 10.05 487 543448 86586 79113867
Mycobacterium tuberculosis complex test positive 10.26 10.05 42 543893 2750 79197703
Hyperhomocysteinaemia 10.24 10.05 15 543920 502 79199951
Hypotonia 10.22 10.05 49 543886 12821 79187632
Eating disorder 10.22 10.05 91 543844 20606 79179847
Tumour haemorrhage 10.17 10.05 8 543927 4136 79196317
Epilepsy 10.14 10.05 207 543728 40653 79159800
Labyrinthitis 10.11 10.05 43 543892 2865 79197588
Lip and/or oral cavity cancer 10.09 10.05 23 543912 1090 79199363
Autonomic nervous system imbalance 10.08 10.05 10 543925 4620 79195833
Retinal haemorrhage 10.08 10.05 26 543909 8191 79192262
Skin injury 10.06 10.05 48 543887 3358 79197095
Precancerous skin lesion 10.06 10.05 26 543909 1335 79199118

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:61115 histone deacetylase inhibitors
CHEBI has role CHEBI:62913 PARP
CHEBI has role CHEBI:63726 neuroprotective agents
CHEBI has role CHEBI:67079 anti-inflammatory agents
CHEBI has role CHEBI:71181 Sir2 inhibitors
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:84087 human urinary metabolites
CHEBI has role CHEBI:176497 geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acne vulgaris indication 88616000
Pellagra indication 418186002 DOID:8457
Niacin deficiency indication 418279001
Methemoglobinemia off-label use 38959009 DOID:10783
Goiter contraindication 3716002 DOID:12176
Peptic ulcer contraindication 13200003 DOID:750
Hyperkalemia contraindication 14140009
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hashimoto thyroiditis contraindication 21983002
Acute tuberculosis contraindication 25629007
Bronchitis contraindication 32398004 DOID:6132
Low blood pressure contraindication 45007003
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Dermatitis herpetiformis contraindication 111196000 DOID:8505
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Arterial hemorrhage contraindication 234003006
Disease of liver contraindication 235856003 DOID:409
Hypocomplementemic urticarial vasculitis contraindication 239945009
Rhabdomyolysis contraindication 240131006
Pregnancy, function contraindication 289908002
Acute coronary syndrome contraindication 394659003
Hemochromatosis contraindication 399187006 DOID:2352




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.95 acidic
pKa2 3.41 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Hydroxycarboxylic acid receptor 2 GPCR WOMBAT-PK
Hydroxycarboxylic acid receptor 3 GPCR WOMBAT-PK
Nicotinamide N-methyltransferase Enzyme WOMBAT-PK
Nicotinate-nucleotide pyrophosphorylase [carboxylating] Enzyme WOMBAT-PK
NAD-dependent protein deacetylase sirtuin-1 Enzyme IC50 4.30 CHEMBL
NAD-dependent protein deacetylase sirtuin-2 Enzyme IC50 5.92 CHEMBL
NAD-dependent deacetylase sirtuin 3 Enzyme IC50 4.85 CHEMBL
NAD-dependent protein deacylase sirtuin-5, mitochondrial Enzyme IC50 4.33 CHEMBL
Sterile alpha and TIR motif-containing protein 1 Unclassified IC50 4.36 CHEMBL
Fatty-acid amide hydrolase 1 Enzyme IC50 5.48 CHEMBL
NAD-dependent deacetylase HST2 Enzyme IC50 4.04 CHEMBL
Putative silent information regulator 2 Unclassified IC50 4.40 CHEMBL
NAD-dependent protein deacetylase Unclassified IC50 4.64 CHEMBL
NAD-dependent protein deacetylase Unclassified IC50 4.41 CHEMBL

External reference:

IDSource
4020285 VUID
N0000148162 NUI
D00036 KEGG_DRUG
4017632 VANDF
4017718 VANDF
4020285 VANDF
C0028027 UMLSCUI
CHEBI:17154 CHEBI
NCA PDB_CHEM_ID
CHEMBL1140 ChEMBL_ID
936 PUBCHEM_CID
DB02701 DRUGBANK_ID
7405 RXNORM
4947 MMSL
5170 MMSL
5684 MMSL
72420 MMSL
d03739 MMSL
001055 NDDF
173196005 SNOMEDCT_US
D009536 MESH_DESCRIPTOR_UI
404 INN_ID
25X51I8RD4 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 20 mg ORAL Unapproved drug other 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 20 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 20 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 20 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 20 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 20 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 20 mg ORAL Unapproved drug other 11 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 15 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 15 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 15 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 25 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 25 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 15 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 15 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 20 mg ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 100 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 20 mg ORAL Unapproved drug other 7 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 20 mg ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 20 mg ORAL UNAPPROVED DRUG OTHER 7 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 15 mg ORAL unapproved drug other 15 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 15 mg ORAL unapproved drug other 15 sections