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nesiritide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| natriuretic peptides | 1901 | 124584-08-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1.50 | mg | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.19 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 9.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 0.30 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 10, 2001 | FDA | SCIOS LLC |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C01DX19 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY VASODILATORS USED IN CARDIAC DISEASES Other vasodilators used in cardiac diseases |
| FDA CS | M0447624 | Natriuretic Peptides |
| FDA EPC | N0000175593 | Natriuretic Peptide |
| CHEBI has role | CHEBI:35526 | hypoglycemic agent |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:35674 | antihypertensive agent |
| CHEBI has role | CHEBI:74518 | anti-obesity agent |
| CHEBI has role | CHEBI:231911 | renoprotective agent |
Related Drugs by ATC class:
C01DX Other vasodilators used in cardiac diseases 18 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Decompensated cardiac failure | indication | 195111005 | |
| Decompensated chronic heart failure | indication | 424404003 | |
| Cardiac tamponade | contraindication | 35304003 | DOID:115 |
| Low blood pressure | contraindication | 45007003 | |
| Aortic valve stenosis | contraindication | 60573004 | DOID:1712 |
| Constrictive pericarditis | contraindication | 85598007 | DOID:11481 |
| Cardiogenic shock | contraindication | 89138009 | |
| Hypertrophic cardiomyopathy | contraindication | 233873004 | DOID:11984 |
| Azotemia | contraindication | 445009001 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.72 | acidic |
| pKa2 | 3.79 | acidic |
| pKa3 | 12.09 | acidic |
| pKa4 | 12.32 | acidic |
| pKa5 | 12.47 | acidic |
| pKa6 | 12.62 | acidic |
| pKa7 | 12.91 | acidic |
| pKa8 | 13.0 | acidic |
| pKa9 | 13.23 | acidic |
| pKa10 | 13.25 | acidic |
| pKa11 | 13.46 | acidic |
| pKa12 | 13.46 | acidic |
| pKa13 | 13.49 | acidic |
| pKa14 | 13.57 | acidic |
| pKa15 | 13.74 | acidic |
| pKa16 | 13.84 | acidic |
| pKa17 | 13.89 | acidic |
| pKa18 | 13.93 | acidic |
| pKa19 | 11.5 | Basic |
| pKa20 | 11.27 | Basic |
| pKa21 | 11.02 | Basic |
| pKa22 | 10.75 | Basic |
| pKa23 | 10.54 | Basic |
| pKa24 | 10.29 | Basic |
| pKa25 | 9.93 | Basic |
| pKa26 | 8.08 | Basic |
| pKa27 | 6.88 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Atrial natriuretic peptide receptor 1 | Enzyme | AGONIST | DRUG LABEL | DRUG LABEL |
External reference:
| ID | Source |
|---|---|
| 4024230 | VUID |
| N0000022235 | NUI |
| D05147 | KEGG_DRUG |
| 4021275 | VANDF |
| 4024230 | VANDF |
| C0054015 | UMLSCUI |
| CHEBI:135919 | CHEBI |
| CHEMBL1201668 | ChEMBL_ID |
| DB04899 | DRUGBANK_ID |
| 7790 | INN_ID |
| P7WI8UL647 | UNII |
| 71308561 | PUBCHEM_CID |
| 19666 | RXNORM |
| 16114 | MMSL |
| d04763 | MMSL |
| 009299 | NDDF |
| 009300 | NDDF |
| 385678006 | SNOMEDCT_US |
| 385680000 | SNOMEDCT_US |
| 407059007 | SNOMEDCT_US |
Pharmaceutical products:
None