mycophenolic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1860 37415-62-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mycophenolate
  • mycophenolic acid
  • mycophenolate sodium
  • mycophenolic acid monosodium salt
  • sodium mycophenolate
Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.
  • Molecular weight: 320.34
  • Formula: C17H20O6
  • CLOGP: 2.29
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 93.06
  • ALOGS: -3.96
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 g O
2 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 64.22 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.77 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.33 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 9.70 hours Lombardo F, Berellini G, Obach RS
BA (Bioavailability) 94 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.457 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.400 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 71.945 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 20.370 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 4.470 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 4.880 % High 1
herg hERG pIC50 4.399 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 12.359 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.148 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 2.590 % High 1
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK1,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM1,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 68
kinase-selectivity-class ACVR2B,AXL,BRAF,CDK9,EIF2AK3,EPHB4,GRK2,MAP2K6,MAP3K14,MAPK7,PRKDC,STK33,TEK,TGFBR1,TTK 15
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 4.966 High 1
mh-clint Mouse hepatocyte intrinsic clearance 53.951 High 1
mppb Mouse plasma protein binding (% unbound) 8.590 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.991 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
pppb Pig plasma protein binding (% unbound) 5.670 % High 1
rh-clint Rat hepatocyte intrinsic clearance 37.844 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 84.900 % High 1
rppb Rat plasma protein binding (% unbound) 1.570 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 853.100 uM High 1

Approvals:

DateAgencyCompanyOrphan
Feb. 27, 2004 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 934 10.47 393 47186 26209 90554659
Transplant rejection 901.84 10.47 314 47265 12444 90568424
Kidney transplant rejection 606.21 10.47 184 47395 4673 90576195
Post transplant lymphoproliferative disorder 576.94 10.47 193 47386 6756 90574112
Cytomegalovirus viraemia 351.88 10.47 137 47442 7449 90573419
Thrombotic microangiopathy 346.54 10.47 168 47411 15575 90565293
Complications of transplanted kidney 337.72 10.47 104 47475 2774 90578094
Off label use 317.68 10.47 1277 46302 1100975 89479893
Polyomavirus-associated nephropathy 292.26 10.47 90 47489 2400 90578468
Posterior reversible encephalopathy syndrome 285.88 10.47 166 47413 22173 90558695
Leukopenia 265.63 10.47 295 47284 100415 90480453
Immunosuppressant drug level increased 258.43 10.47 96 47483 4584 90576284
Renal impairment 231.44 10.47 281 47298 105140 90475728
COVID-19 222.79 10.47 352 47227 168491 90412377
BK virus infection 218.44 10.47 84 47495 4414 90576454
Acute kidney injury 210.81 10.47 497 47082 319890 90260978
Multiple organ dysfunction syndrome 206.19 10.47 215 47364 68121 90512747
Epstein-Barr virus infection 205.63 10.47 103 47476 10241 90570627
Delayed graft function 199.48 10.47 59 47520 1366 90579502
Blood creatinine increased 198.17 10.47 255 47324 101131 90479737
Kidney fibrosis 185.21 10.47 62 47517 2172 90578696
Pneumocystis jirovecii pneumonia 181.60 10.47 123 47456 21493 90559375
Chronic allograft nephropathy 174.65 10.47 47 47532 762 90580106
Polyomavirus viraemia 173.37 10.47 52 47527 1265 90579603
Proteinuria 161.85 10.47 118 47461 23173 90557695
Nephropathy toxic 153.66 10.47 91 47488 12597 90568271
Central nervous system lupus 150.43 10.47 47 47532 1316 90579552
Aspergillus infection 145.31 10.47 83 47496 10740 90570128
Histoplasmosis disseminated 144.79 10.47 52 47527 2253 90578615
Parvovirus B19 infection 142.34 10.47 42 47537 964 90579904
Lupus nephritis 141.95 10.47 63 47516 4769 90576099
Respiratory failure 139.97 10.47 235 47344 118183 90462685
Glossodynia 139.92 10.47 7 47572 321772 90259096
Trichodysplasia spinulosa 138.44 10.47 38 47541 666 90580202
Renal transplant failure 133.20 10.47 41 47538 1091 90579777
Klebsiella infection 133.00 10.47 77 47502 10220 90570648
Pain 132.87 10.47 199 47380 996142 89584726
Graft versus host disease in skin 125.42 10.47 54 47525 3799 90577069
Haemophagocytic lymphohistiocytosis 125.19 10.47 86 47493 15373 90565495
Nocardiosis 124.81 10.47 48 47531 2522 90578346
Product use in unapproved indication 122.96 10.47 422 47157 335814 90245054
Arthropathy 122.89 10.47 22 47557 366220 90214648
Varicella zoster virus infection 118.57 10.47 52 47527 3825 90577043
Escherichia infection 118.38 10.47 84 47495 15811 90565057
Hand deformity 118.36 10.47 10 47569 296352 90284516
Graft versus host disease in gastrointestinal tract 115.53 10.47 53 47526 4335 90576533
Transplant dysfunction 115.11 10.47 56 47523 5226 90575642
Human herpesvirus 6 infection 111.38 10.47 48 47531 3384 90577484
West Nile viral infection 110.65 10.47 30 47549 501 90580367
Liver transplant rejection 108.60 10.47 39 47540 1689 90579179
Epstein-Barr viraemia 106.98 10.47 37 47542 1433 90579435
Anti-cyclic citrullinated peptide antibody positive 106.54 10.47 4 47575 236429 90344439
Focal segmental glomerulosclerosis 105.98 10.47 39 47540 1812 90579056
Tubulointerstitial nephritis 105.12 10.47 95 47484 25248 90555620
Disease recurrence 102.12 10.47 112 47467 37541 90543327
Infusion related reaction 96.79 10.47 49 47530 416731 90164137
Brain abscess 96.78 10.47 41 47538 2771 90578097
Joint swelling 96.43 10.47 74 47505 503226 90077642
Urinary tract infection 95.89 10.47 365 47214 305267 90275601
Blastomycosis 95.85 10.47 26 47553 435 90580433
Wound 95.74 10.47 21 47558 302959 90277909
Fatigue 95.28 10.47 301 47278 1153722 89427146
Bronchopulmonary aspergillosis 93.69 10.47 64 47515 11334 90569534
Adenovirus infection 91.79 10.47 46 47533 4576 90576292
Cryptococcosis 91.70 10.47 33 47546 1438 90579430
Enterococcal infection 91.50 10.47 60 47519 9931 90570937
Hypersensitivity 90.78 10.47 64 47515 454613 90126255
Phaeohyphomycosis 90.04 10.47 25 47554 458 90580410
Duodenal ulcer perforation 89.64 10.47 7 47572 221281 90359587
Acute respiratory distress syndrome 89.62 10.47 92 47487 28594 90552274
Cytomegalovirus colitis 89.46 10.47 41 47538 3345 90577523
Cerebral toxoplasmosis 89.39 10.47 32 47547 1373 90579495
Apoptosis 88.32 10.47 19 47560 109 90580759
Pemphigus 87.76 10.47 31 47548 326833 90254035
Central nervous system lymphoma 87.71 10.47 35 47544 2030 90578838
Pulmonary nocardiosis 85.91 10.47 27 47552 771 90580097
Lymphocele 85.48 10.47 27 47552 784 90580084
Drug hypersensitivity 85.23 10.47 71 47508 463538 90117330
Discomfort 84.70 10.47 20 47559 274315 90306553
Swelling 83.63 10.47 59 47520 418999 90161869
COVID-19 pneumonia 83.09 10.47 72 47507 18105 90562763
Septic shock 82.60 10.47 154 47425 84006 90496862
Synovitis 82.37 10.47 35 47544 329717 90251151
Drug interaction 81.67 10.47 324 47255 276129 90304739
Contraindicated product administered 81.54 10.47 33 47546 320106 90260762
Pericarditis 80.87 10.47 21 47558 270130 90310738
Renal transplant 80.10 10.47 31 47548 1657 90579211
Helicobacter infection 79.68 10.47 12 47567 226838 90354030
Muscle injury 79.53 10.47 3 47576 176651 90404217
Histoplasmosis 78.74 10.47 33 47546 2171 90578697
Folliculitis 78.62 10.47 8 47571 204345 90376523
Disseminated tuberculosis 78.03 10.47 37 47542 3262 90577606
Blister 77.91 10.47 19 47560 254979 90325889
Irritable bowel syndrome 77.57 10.47 9 47570 207439 90373429
Herpes simplex hepatitis 76.08 10.47 23 47556 575 90580293
Urine protein/creatinine ratio increased 75.69 10.47 26 47553 986 90579882
Aplasia pure red cell 75.59 10.47 42 47537 5152 90575716
Sepsis 74.86 10.47 236 47343 179578 90401290
Vaccination failure 74.82 10.47 27 47552 1186 90579682
Rash 74.81 10.47 195 47384 795905 89784963
Fibromyalgia 74.57 10.47 10 47569 206259 90374609
Wheezing 74.20 10.47 17 47562 238063 90342805
Stomatitis 73.82 10.47 26 47553 274672 90306196
Graft loss 73.07 10.47 21 47558 438 90580430
Protein urine present 71.52 10.47 45 47534 6939 90573929
Body mass index abnormal 71.29 10.47 23 47556 716 90580152
Drug level increased 70.84 10.47 80 47499 27682 90553186
Disseminated cryptococcosis 70.39 10.47 23 47556 746 90580122
Angiosarcoma 70.36 10.47 18 47561 237 90580631
Alopecia 69.58 10.47 95 47484 494976 90085892
Renal tubular necrosis 69.26 10.47 59 47520 14496 90566372
Hepatic enzyme increased 69.08 10.47 53 47526 360683 90220185
Biloma 69.01 10.47 15 47564 91 90580777
Serositis 69.00 10.47 26 47553 1291 90579577
Human ehrlichiosis 68.76 10.47 17 47562 193 90580675
Post transplant distal limb syndrome 68.43 10.47 19 47560 348 90580520
Cat scratch disease 68.31 10.47 18 47561 268 90580600
Drug ineffective for unapproved indication 67.97 10.47 124 47455 66520 90514348
C3 glomerulopathy 66.47 10.47 16 47563 161 90580707
Renal tubular atrophy 65.86 10.47 23 47556 917 90579951
Infection reactivation 65.82 10.47 28 47551 1912 90578956
Transplant failure 65.42 10.47 28 47551 1941 90578927
Rheumatoid factor positive 65.30 10.47 7 47572 171643 90409225
Osteoarthritis 65.07 10.47 12 47567 195718 90385150
Scedosporium infection 64.82 10.47 22 47557 804 90580064
Encephalitis viral 63.21 10.47 27 47552 1862 90579006
JC virus infection 62.80 10.47 30 47549 2689 90578179
Oesophageal ulcer 62.73 10.47 37 47542 5082 90575786
Mobility decreased 61.98 10.47 27 47552 250707 90330161
Pancreas transplant rejection 61.87 10.47 15 47564 156 90580712
Drug effective for unapproved indication 61.64 10.47 43 47536 7875 90572993
Rheumatoid arthritis 61.27 10.47 60 47519 362554 90218314
Hypogammaglobulinaemia 60.72 10.47 48 47531 10626 90570242
Human polyomavirus infection 60.48 10.47 18 47561 426 90580442
Arthralgia 59.29 10.47 210 47369 778312 89802556
Contusion 59.07 10.47 29 47550 251187 90329681
Lower respiratory tract infection 58.84 10.47 29 47550 250630 90330238
Dizziness 58.67 10.47 140 47439 589144 89991724
Confusional state 58.50 10.47 70 47509 386135 90194733
Papilloma viral infection 58.08 10.47 25 47554 1757 90579111
Hypoaesthesia 56.62 10.47 49 47530 314161 90266707
Rheumatic fever 56.36 10.47 7 47572 153114 90427754
Viraemia 56.33 10.47 24 47555 1645 90579223
Pathogen resistance 56.11 10.47 41 47538 8074 90572794
Pruritus 56.03 10.47 126 47453 541399 90039469
Diarrhoea 54.57 10.47 741 46838 938449 89642419
Death 54.50 10.47 418 47161 456133 90124735
Injury 54.18 10.47 18 47561 197331 90383537
End stage renal disease 54.11 10.47 41 47538 8530 90572338
Pancreatitis haemorrhagic 53.75 10.47 18 47561 631 90580237
Graft versus host disease 53.73 10.47 40 47539 8104 90572764
Abdominal discomfort 53.61 10.47 106 47473 477222 90103646
Nasopharyngitis 53.36 10.47 82 47497 407022 90173846
Type 2 diabetes mellitus 53.29 10.47 20 47559 203224 90377644
Butterfly rash 53.19 10.47 25 47554 2160 90578708
Genital herpes simplex 52.01 10.47 16 47563 425 90580443
Escherichia urinary tract infection 51.88 10.47 49 47530 13766 90567102
Haematuria 51.85 10.47 77 47502 34860 90546008
Diffuse large B-cell lymphoma 51.60 10.47 40 47539 8605 90572263
Ureaplasma infection 51.56 10.47 19 47560 886 90579982
Asthma 51.08 10.47 32 47547 242128 90338740
Calciphylaxis 51.06 10.47 28 47551 3348 90577520
Injection site pain 51.02 10.47 14 47565 173685 90407183
Emphysematous pyelonephritis 50.89 10.47 15 47564 343 90580525
Depression 50.47 10.47 50 47529 300551 90280317
Atypical haemolytic uraemic syndrome 49.88 10.47 19 47560 972 90579896
Chromoblastomycosis 49.86 10.47 10 47569 38 90580830
Bacteraemia 49.78 10.47 60 47519 22240 90558628
Angiosarcoma metastatic 49.50 10.47 11 47568 75 90580793
Nephropathy 49.27 10.47 40 47539 9195 90571673
Urticaria 49.16 10.47 55 47524 312679 90268189
Bursitis 48.50 10.47 6 47573 131648 90449220
Toxoplasmosis 48.37 10.47 22 47557 1763 90579105
Strongyloidiasis 47.42 10.47 21 47558 1581 90579287
Interstitial lung disease 47.36 10.47 116 47463 76289 90504579
Thrombocytopenia 47.32 10.47 226 47353 208499 90372369
Haemolytic uraemic syndrome 47.22 10.47 25 47554 2786 90578082
Pseudomonas infection 47.02 10.47 48 47531 14817 90566051
Acarodermatitis 47.01 10.47 20 47559 1366 90579502
Musculoskeletal stiffness 46.77 10.47 52 47527 296480 90284388
Epidermodysplasia verruciformis 46.77 10.47 12 47567 160 90580708
Immunosuppressant drug level decreased 46.73 10.47 19 47560 1157 90579711
Cytomegalovirus infection reactivation 46.36 10.47 36 47543 7764 90573104
Sinusitis 46.01 10.47 68 47511 343020 90237848
Insomnia 45.80 10.47 65 47514 333409 90247459
Renal failure 45.66 10.47 162 47417 130845 90450023
Epstein-Barr virus associated lymphoproliferative disorder 45.60 10.47 24 47555 2643 90578225
Cystitis haemorrhagic 45.41 10.47 31 47548 5482 90575386
Mucormycosis 45.20 10.47 27 47552 3794 90577074
Pneumonia cytomegaloviral 44.85 10.47 25 47554 3086 90577782
Herpes simplex oesophagitis 44.62 10.47 12 47567 194 90580674
Bacillary angiomatosis 44.32 10.47 11 47568 127 90580741
General physical health deterioration 44.19 10.47 74 47505 355041 90225827
Therapeutic product effect decreased 43.42 10.47 49 47530 277522 90303346
Sleep disorder 43.40 10.47 25 47554 198005 90382863
Microsporidia infection 42.70 10.47 13 47566 333 90580535
Hospitalisation 42.60 10.47 156 47423 127944 90452924
Glomerulonephritis membranoproliferative 42.52 10.47 13 47566 338 90580530
Anxiety 41.92 10.47 61 47518 309711 90271157
Blood cholesterol increased 41.82 10.47 29 47550 207983 90372885
Diabetes mellitus 41.81 10.47 100 47479 64775 90516093
Oesophageal candidiasis 41.64 10.47 32 47547 6797 90574071
Psoriasis 41.39 10.47 13 47566 147741 90433127
Hepatitis E 40.98 10.47 20 47559 1879 90578989
Mycoplasma infection 40.87 10.47 16 47563 882 90579986
Epstein-Barr virus associated lymphoma 40.84 10.47 15 47564 693 90580175
Acute respiratory failure 40.19 10.47 77 47502 42841 90538027
Anaemia 39.83 10.47 319 47260 352483 90228385
Pain in extremity 39.48 10.47 114 47465 450415 90130453
Psoriatic arthropathy 39.45 10.47 37 47542 228298 90352570
Dry mouth 39.26 10.47 24 47555 184035 90396833
Pyelonephritis 39.09 10.47 52 47527 21264 90559604
Malacoplakia 38.96 10.47 12 47567 320 90580548
Systemic mycosis 38.78 10.47 18 47561 1512 90579356
Swollen joint count increased 38.76 10.47 6 47573 111200 90469668
Sleep disorder due to general medical condition, insomnia type 38.49 10.47 10 47569 128684 90452184
Chorioretinitis 38.47 10.47 15 47564 818 90580050
Oedematous kidney 38.13 10.47 10 47569 146 90580722
Biopsy lung abnormal 37.94 10.47 10 47569 149 90580719
Pancytopenia 37.94 10.47 144 47435 120119 90460749
Abortion spontaneous 37.76 10.47 86 47493 53970 90526898
Oesophageal stenosis 37.49 10.47 24 47555 3812 90577056
Chronic kidney disease 37.47 10.47 82 47497 50109 90530759
Necrotising retinitis 36.81 10.47 13 47566 536 90580332
Malignant neoplasm progression 36.72 10.47 6 47573 106864 90474004
Pneumonia fungal 36.56 10.47 30 47549 7001 90573867
Acute graft versus host disease 36.39 10.47 27 47552 5441 90575427
Urinary tract candidiasis 36.36 10.47 14 47565 738 90580130
Disseminated toxoplasmosis 36.34 10.47 10 47569 177 90580691
Peptostreptococcus infection 36.26 10.47 9 47570 104 90580764
Herpes simplex 36.13 10.47 35 47544 10146 90570722
Gait inability 35.81 10.47 16 47563 146440 90434428
Renal tubular injury 35.77 10.47 16 47563 1233 90579635
Disseminated strongyloidiasis 35.57 10.47 8 47571 58 90580810
Perinephric abscess 35.37 10.47 11 47568 303 90580565
Lung transplant rejection 35.23 10.47 15 47564 1026 90579842
Enterobacter infection 35.18 10.47 20 47559 2563 90578305
Malacoplakia vesicae 34.66 10.47 8 47571 66 90580802
Grip strength decreased 34.63 10.47 4 47575 92572 90488296
Acanthamoeba infection 34.55 10.47 8 47571 67 90580801
Ill-defined disorder 34.31 10.47 28 47551 184863 90396005
Disseminated intravascular coagulation 34.18 10.47 49 47530 21489 90559379
Lip dry 33.95 10.47 6 47573 100949 90479919
Impaired healing 33.80 10.47 44 47535 234155 90346713
Complications of transplanted lung 33.54 10.47 11 47568 361 90580507
Rhodococcus infection 33.49 10.47 9 47570 145 90580723
Coccidioidomycosis 33.27 10.47 15 47564 1178 90579690
Joint range of motion decreased 32.88 10.47 15 47564 135628 90445240
Transplantation associated food allergy 32.86 10.47 7 47572 38 90580830
Injection site erythema 32.81 10.47 6 47573 98496 90482372
Facet joint syndrome 32.76 10.47 6 47573 98383 90482485
Drug resistance 32.75 10.47 58 47521 30391 90550477
Muscle spasms 32.72 10.47 51 47528 251832 90329036
Distributive shock 32.42 10.47 21 47558 3403 90577465
Haemolytic anaemia 32.06 10.47 35 47544 11662 90569206
Anogenital warts 32.04 10.47 12 47567 586 90580282
Lymphopenia 31.92 10.47 49 47530 22832 90558036
Malaise 31.88 10.47 179 47400 585807 89995061
Transplant 31.85 10.47 14 47565 1035 90579833
Mouth ulceration 31.78 10.47 67 47512 39907 90540961
Constipation 31.67 10.47 62 47517 280333 90300535
Encephalopathy 31.46 10.47 73 47506 46371 90534497
Systemic lupus erythematosus 31.38 10.47 92 47487 361804 90219064
Heart transplant rejection 31.37 10.47 13 47566 831 90580037
Mycobacterium avium complex infection 31.30 10.47 22 47557 4076 90576792
Gastroenteritis norovirus 31.30 10.47 18 47561 2358 90578510
Cytomegalovirus nephritis 31.26 10.47 6 47573 17 90580851
B-cell lymphoma 31.22 10.47 21 47558 3625 90577243
Graft complication 31.22 10.47 10 47569 304 90580564
Fall 30.86 10.47 139 47440 481671 90099197
Glomerulonephritis 30.65 10.47 18 47561 2452 90578416
Escherichia sepsis 30.62 10.47 25 47554 5791 90575077
Organising pneumonia 30.56 10.47 28 47551 7569 90573299
Pyelonephritis fungal 30.48 10.47 9 47570 207 90580661
Hydronephrosis 30.39 10.47 35 47544 12367 90568501
Biliary obstruction 30.32 10.47 20 47559 3342 90577526
Porocarcinoma 30.30 10.47 6 47573 21 90580847
Therapy change 30.27 10.47 29 47550 8293 90572575
Therapy cessation 30.15 10.47 62 47517 36299 90544569
Pyelonephritis acute 29.98 10.47 24 47555 5408 90575460
Donor specific antibody present 29.92 10.47 9 47570 221 90580647
Malacoplakia gastrointestinal 29.49 10.47 7 47572 66 90580802
Renal-limited thrombotic microangiopathy 29.44 10.47 9 47570 234 90580634
Candida infection 29.34 10.47 59 47520 33998 90546870
Disseminated varicella zoster vaccine virus infection 29.21 10.47 7 47572 69 90580799
Cytomegalovirus test positive 29.12 10.47 20 47559 3571 90577297
Neutropenia 29.08 10.47 210 47369 224694 90356174
Encephalomalacia 29.08 10.47 11 47568 552 90580316
Cytomegalovirus hepatitis 28.63 10.47 10 47569 399 90580469
Squamous cell carcinoma of the cervix 28.53 10.47 10 47569 403 90580465
Memory impairment 28.52 10.47 37 47542 197207 90383661
Disseminated mycobacterium avium complex infection 28.44 10.47 9 47570 263 90580605
Prescribed overdose 28.41 10.47 8 47571 97617 90483251
Hyperammonaemia 28.29 10.47 25 47554 6450 90574418
Gait disturbance 28.22 10.47 59 47520 260437 90320431
Agranulocytosis 28.22 10.47 59 47520 34943 90545925
Peripheral venous disease 28.19 10.47 5 47574 83916 90496952
Injection site reaction 27.83 10.47 7 47572 92073 90488795
Peripheral swelling 27.78 10.47 117 47462 412989 90167879
Cardiac valve abscess 27.66 10.47 7 47572 88 90580780
Clostridium difficile colitis 27.61 10.47 50 47529 26656 90554212
Hepatic artery stenosis 27.52 10.47 7 47572 90 90580778
Nephrotic syndrome 27.50 10.47 26 47553 7313 90573555
Anal squamous cell carcinoma 27.37 10.47 11 47568 650 90580218
Solid organ transplant rejection 27.25 10.47 6 47573 39 90580829
Disseminated mucormycosis 27.21 10.47 11 47568 660 90580208
Mycobacterial infection 27.15 10.47 16 47563 2194 90578674
Norovirus infection 27.08 10.47 15 47564 1829 90579039
Cytomegalovirus syndrome 27.03 10.47 7 47572 97 90580771
Progressive multifocal leukoencephalopathy 26.89 10.47 37 47542 15618 90565250
Chronic myeloid leukaemia 26.86 10.47 17 47562 2647 90578221
Locked-in syndrome 26.82 10.47 10 47569 482 90580386
Obesity 26.63 10.47 11 47568 105496 90475372
Philadelphia positive chronic myeloid leukaemia 26.62 10.47 6 47573 44 90580824
Back pain 26.50 10.47 82 47497 317093 90263775
Medication error 26.44 10.47 6 47573 84646 90496222
SARS-CoV-2 antibody test negative 26.39 10.47 9 47570 334 90580534
Hypercholesterolaemia 26.32 10.47 10 47569 100882 90479986
Lung transplant 26.31 10.47 19 47560 3673 90577195
Glomerulosclerosis 26.28 10.47 10 47569 510 90580358
Mycobacterium haemophilum infection 26.24 10.47 8 47571 206 90580662
Plasmapheresis 26.13 10.47 9 47570 344 90580524
Dry skin 26.04 10.47 7 47572 88066 90492802
Pulmonary alveolar haemorrhage 25.89 10.47 23 47556 5975 90574893
Escherichia pyelonephritis 25.86 10.47 11 47568 751 90580117
Knee arthroplasty 25.78 10.47 6 47573 83176 90497692
Periumbilical abscess 25.77 10.47 8 47571 219 90580649
Ureteral necrosis 25.63 10.47 6 47573 53 90580815
Fungal infection 25.61 10.47 64 47515 42597 90538271
Complications of transplanted heart 25.59 10.47 7 47572 121 90580747
Oedematous pancreatitis 25.54 10.47 11 47568 774 90580094
Systemic candida 25.45 10.47 21 47558 4938 90575930
Acute graft versus host disease in intestine 25.38 10.47 15 47564 2068 90578800
Delusional disorder, erotomanic type 25.33 10.47 6 47573 56 90580812
Diabetic macroangiopathy 25.32 10.47 7 47572 126 90580742
Incision site pain 25.28 10.47 13 47566 1365 90579503
Perinephric collection 25.12 10.47 7 47572 130 90580738
Renal disorder 25.09 10.47 59 47520 37800 90543068
Hepatic angiosarcoma 24.93 10.47 5 47574 19 90580849
Encephalitis 24.92 10.47 30 47549 11104 90569764
Tuberculosis gastrointestinal 24.90 10.47 9 47570 397 90580471
Catheter site abscess 24.86 10.47 8 47571 247 90580621
Therapy interrupted 24.84 10.47 70 47509 50038 90530830
Mastitis bacterial 24.78 10.47 6 47573 62 90580806
Cytomegalovirus oesophagitis 24.69 10.47 9 47570 407 90580461
Hyperparathyroidism secondary 24.68 10.47 14 47565 1787 90579081
Cryptosporidiosis infection 24.48 10.47 9 47570 417 90580451
Decreased appetite 24.48 10.47 108 47471 376432 90204436
Meningitis cryptococcal 24.45 10.47 14 47565 1819 90579049
Endocarditis 24.39 10.47 24 47555 7089 90573779
Asthenia 24.39 10.47 172 47407 533579 90047289
Alveolar proteinosis 24.38 10.47 11 47568 865 90580003
Colon injury 24.38 10.47 8 47571 263 90580605
Deep vein thrombosis postoperative 24.27 10.47 4 47575 70805 90510063
Forced vital capacity decreased 24.21 10.47 12 47567 1166 90579702
Prescribed underdose 24.08 10.47 5 47574 75014 90505854
Azotaemia 24.07 10.47 21 47558 5327 90575541
Joint tuberculosis 24.00 10.47 7 47572 154 90580714
Metabolic acidosis 23.99 10.47 74 47505 55602 90525266
Vitritis infective 23.82 10.47 5 47574 25 90580843
Disseminated cytomegaloviral infection 23.55 10.47 8 47571 293 90580575
Monkeypox 23.50 10.47 5 47574 27 90580841
Vaginal lesion 23.47 10.47 9 47570 469 90580399
Treatment noncompliance 23.46 10.47 70 47509 51657 90529211
Cytomegalovirus chorioretinitis 23.31 10.47 15 47564 2404 90578464
Nasal cavity cancer 23.25 10.47 6 47573 82 90580786
Dermatomyositis 23.24 10.47 17 47562 3353 90577515
Urinary fistula 23.19 10.47 5 47574 29 90580839
Drug level decreased 23.07 10.47 27 47552 9703 90571165
Septic embolus 23.02 10.47 11 47568 986 90579882
Polyomavirus test positive 22.85 10.47 6 47573 88 90580780
Steroid diabetes 22.85 10.47 15 47564 2487 90578381
Balamuthia infection 22.79 10.47 6 47573 89 90580779
Neck pain 22.75 10.47 16 47563 113947 90466921
Liver abscess 22.68 10.47 17 47562 3479 90577389
Drug ineffective 22.66 10.47 914 46665 1383384 89197484
Klebsiella bacteraemia 22.36 10.47 15 47564 2577 90578291
Hyperamylasaemia 22.31 10.47 9 47570 537 90580331
Squamous cell carcinoma 22.25 10.47 27 47552 10074 90570794
Skin hypertrophy 22.19 10.47 17 47562 3593 90577275
Bacterial endophthalmitis 22.14 10.47 7 47572 204 90580664
Rhinovirus infection 22.10 10.47 21 47558 5942 90574926
Night sweats 22.07 10.47 21 47558 128745 90452123
Diffuse alveolar damage 22.04 10.47 11 47568 1084 90579784
Haemoglobin decreased 21.96 10.47 153 47426 161803 90419065
Transplantation complication 21.91 10.47 7 47572 211 90580657
Obliterative bronchiolitis 21.90 10.47 15 47564 2666 90578202
Concomitant disease progression 21.90 10.47 14 47565 2218 90578650
Tuberculoma of central nervous system 21.90 10.47 8 47571 364 90580504
Road traffic accident 21.63 10.47 15 47564 107611 90473257
Urinoma 21.58 10.47 5 47574 42 90580826
Immunosuppression 21.44 10.47 29 47550 12048 90568820
Paraesthesia 21.42 10.47 64 47515 250262 90330606
Pemphigoid 21.32 10.47 25 47554 9001 90571867
Orthobunyavirus test positive 21.21 10.47 4 47575 10 90580858
Meningitis histoplasma 21.21 10.47 4 47575 10 90580858
Urinary tract infection bacterial 21.17 10.47 21 47558 6264 90574604
Hepatitis C 21.11 10.47 20 47559 5640 90575228
Human herpesvirus 6 encephalitis 21.08 10.47 8 47571 405 90580463
Osteomalacia 21.05 10.47 10 47569 885 90579983
Human herpesvirus 6 infection reactivation 21.01 10.47 9 47570 625 90580243
Antisynthetase syndrome 20.97 10.47 6 47573 123 90580745
American trypanosomiasis 20.94 10.47 7 47572 244 90580624
Eye infection toxoplasmal 20.92 10.47 8 47571 414 90580454
Pneumonia cryptococcal 20.83 10.47 11 47568 1220 90579648
Liver injury 20.77 10.47 36 47543 170531 90410337
Migraine 20.72 10.47 43 47536 190349 90390519
Dermatitis papillaris capillitii 20.67 10.47 4 47575 12 90580856
Gout 20.62 10.47 34 47545 16825 90564043
Product quality issue 20.46 10.47 8 47571 79317 90501551
Vasogenic cerebral oedema 20.34 10.47 11 47568 1279 90579589
Paraspinal abscess 20.31 10.47 7 47572 268 90580600
Chronic graft versus host disease 20.15 10.47 17 47562 4122 90576746
Intentional product misuse 20.07 10.47 11 47568 89593 90491275
Secondary immunodeficiency 20.03 10.47 13 47566 2113 90578755
Hepatic fibrosis 20.02 10.47 17 47562 4158 90576710
Angiocentric lymphoma 19.90 10.47 9 47570 712 90580156
Bacterial pyelonephritis 19.85 10.47 8 47571 476 90580392
Colitis 19.82 10.47 81 47498 69861 90511007
Suicidal ideation 19.80 10.47 7 47572 73848 90507020
Urosepsis 19.76 10.47 38 47541 21194 90559674
Renal lymphocele 19.60 10.47 5 47574 65 90580803
Red blood cells urine positive 19.42 10.47 15 47564 3210 90577658
Weight increased 19.41 10.47 134 47445 417793 90163075
Mucinous adenocarcinoma of appendix 19.40 10.47 4 47575 18 90580850
Erythema 19.33 10.47 59 47520 229187 90351681
Systemic bacterial infection 19.22 10.47 4 47575 19 90580849
Musculoskeletal pain 19.21 10.47 38 47541 171213 90409655
Glomerular filtration rate decreased 19.18 10.47 33 47546 16899 90563969
Renal haemorrhage 19.03 10.47 10 47569 1098 90579770
Kidney infection 18.96 10.47 42 47537 25874 90554994
Product use issue 18.89 10.47 99 47480 329820 90251048
New onset diabetes after transplantation 18.87 10.47 6 47573 178 90580690
Pancreatic pseudocyst 18.84 10.47 9 47570 806 90580062
Live birth 18.78 10.47 9 47570 79098 90501770
Pancreatitis necrotising 18.70 10.47 13 47566 2368 90578500
Blood urine present 18.70 10.47 33 47546 17245 90563623
Cervicitis 18.61 10.47 8 47571 560 90580308
Cervical dysplasia 18.48 10.47 16 47563 4018 90576850
Acid base balance abnormal 18.47 10.47 7 47572 353 90580515
Inflammatory myofibroblastic tumour 18.47 10.47 5 47574 83 90580785
Neuroendocrine carcinoma of the skin 18.40 10.47 9 47570 849 90580019
C-reactive protein abnormal 18.32 10.47 24 47555 127405 90453463
Haemoperitoneum 18.23 10.47 15 47564 3513 90577355
Pregnancy 18.21 10.47 5 47574 62042 90518826
Pneumopericardium 18.19 10.47 5 47574 88 90580780
Alternaria infection 18.18 10.47 7 47572 369 90580499
Shock 18.15 10.47 44 47535 28734 90552134
Reversible cerebral vasoconstriction syndrome 18.15 10.47 16 47563 4114 90576754
Thrombotic thrombocytopenic purpura 18.12 10.47 16 47563 4122 90576746
Acute graft versus host disease in skin 18.11 10.47 17 47562 4739 90576129
Heart transplant 18.03 10.47 8 47571 605 90580263
Human herpesvirus 8 infection 17.91 10.47 7 47572 384 90580484
Total lung capacity abnormal 17.88 10.47 5 47574 94 90580774
Multiple sclerosis relapse 17.82 10.47 3 47576 52302 90528566
Intentional overdose 17.66 10.47 14 47565 93820 90487048
Complications of transplanted liver 17.57 10.47 7 47572 404 90580464
Pyrexia 17.47 10.47 462 47117 660023 89920845
Cytomegalovirus gastrointestinal infection 17.46 10.47 7 47572 411 90580457
Graft versus host disease in liver 17.42 10.47 9 47570 954 90579914
Metastases to spleen 17.36 10.47 6 47573 232 90580636
Neutrophil Pelger-Huet anomaly present 17.23 10.47 5 47574 108 90580760
Neutrophil count decreased 17.19 10.47 8 47571 71524 90509344
Blindness 17.16 10.47 41 47538 26527 90554341
Pancreatitis acute 17.04 10.47 46 47533 32069 90548799
Pulmonary function test decreased 16.99 10.47 16 47563 4478 90576390
Lower limb fracture 16.88 10.47 12 47567 85001 90495867
Pericardial effusion 16.85 10.47 50 47529 36783 90544085
Fungaemia 16.80 10.47 14 47565 3336 90577532
Abdominal pain upper 16.79 10.47 104 47475 332570 90248298
Encephalitis cytomegalovirus 16.78 10.47 8 47571 714 90580154
Acute oesophageal mucosal lesion 16.69 10.47 5 47574 121 90580747
Hepatitis B reactivation 16.68 10.47 15 47564 3959 90576909
Cardiac murmur functional 16.64 10.47 4 47575 40 90580828
Blood urea increased 16.58 10.47 44 47535 30369 90550499
Toxicity to various agents 16.54 10.47 227 47352 287619 90293249
Injection site pruritus 16.45 10.47 4 47575 53830 90527038
Peliosis hepatis 16.39 10.47 5 47574 129 90580739
Clostridium difficile infection 16.39 10.47 49 47530 36196 90544672
Autoimmune disorder 16.36 10.47 10 47569 76734 90504134
Nosocomial infection 16.34 10.47 11 47568 1902 90578966
Acute motor axonal neuropathy 16.29 10.47 4 47575 44 90580824
Microvascular coronary artery disease 16.28 10.47 6 47573 280 90580588
Infectious pleural effusion 16.27 10.47 11 47568 1914 90578954
Metastatic squamous cell carcinoma 16.26 10.47 6 47573 281 90580587
Vascular hyalinosis 16.13 10.47 4 47575 46 90580822
Leukocytosis 16.05 10.47 44 47535 30946 90549922
Neutrophil count increased 16.00 10.47 33 47546 19357 90561511
Fungal sepsis 15.96 10.47 10 47569 1531 90579337
Metastases to soft tissue 15.94 10.47 6 47573 297 90580571
Acute pulmonary histoplasmosis 15.93 10.47 5 47574 142 90580726
Pseudomonal bacteraemia 15.92 10.47 11 47568 1983 90578885
Orbital apex syndrome 15.90 10.47 4 47575 49 90580819
Vesicoureteric reflux 15.85 10.47 6 47573 302 90580566
Disseminated coccidioidomycosis 15.83 10.47 5 47574 145 90580723
Cerebrospinal fluid leakage 15.80 10.47 10 47569 1557 90579311
Lymphoproliferative disorder 15.78 10.47 15 47564 4247 90576621
Enterococcal bacteraemia 15.75 10.47 11 47568 2017 90578851
Symblepharon 15.75 10.47 6 47573 307 90580561
Gastrointestinal mucormycosis 15.73 10.47 6 47573 308 90580560
Systemic scleroderma 15.67 10.47 10 47569 1579 90579289
Hypophosphataemia 15.60 10.47 28 47551 14826 90566042
Infective keratitis 15.54 10.47 4 47575 54 90580814
Infective scleritis 15.54 10.47 4 47575 54 90580814
Ureteral stent removal 15.50 10.47 3 47576 9 90580859
Bacteroides bacteraemia 15.34 10.47 4 47575 57 90580811
Candida sepsis 15.31 10.47 10 47569 1643 90579225
Premature delivery 15.31 10.47 50 47529 38712 90542156
Influenza like illness 15.21 10.47 12 47567 80599 90500269
Hyperkalaemia 15.18 10.47 71 47508 64893 90515975
Pulmonary mucormycosis 15.02 10.47 7 47572 593 90580275
Amnesia 15.02 10.47 21 47558 108484 90472384
Adverse event 15.02 10.47 24 47555 117394 90463474
Pantoea agglomerans infection 14.97 10.47 4 47575 63 90580805
Eye infection viral 14.97 10.47 5 47574 174 90580694
Albuminuria 14.92 10.47 6 47573 355 90580513
Mediastinal shift 14.91 10.47 4 47575 64 90580804
Tremor 14.87 10.47 134 47445 153039 90427829
Listeriosis 14.83 10.47 10 47569 1733 90579135
Hip arthroplasty 14.81 10.47 11 47568 76197 90504671
Brain natriuretic peptide increased 14.80 10.47 17 47562 5988 90574880
Electrocardiogram QT prolonged 14.69 10.47 10 47569 72446 90508422
Intracranial pressure increased 14.67 10.47 18 47561 6793 90574075
Postoperative ileus 14.65 10.47 7 47572 628 90580240
Vasculitis 14.64 10.47 35 47544 22658 90558210
Hypoxic-ischaemic encephalopathy 14.63 10.47 15 47564 4653 90576215
Hypervolaemia 14.54 10.47 44 47535 32713 90548155
Coagulation test abnormal 14.54 10.47 8 47571 963 90579905
Renal graft infection 14.53 10.47 6 47573 380 90580488
Purulent pericarditis 14.52 10.47 4 47575 71 90580797
Biopsy kidney 14.50 10.47 5 47574 192 90580676
H3N2 influenza 14.46 10.47 3 47576 14 90580854
Mycobacterium chelonae infection 14.42 10.47 7 47572 650 90580218
Liver disorder 14.40 10.47 26 47553 121243 90459625
Anuria 14.38 10.47 27 47552 14791 90566077
Sebaceous carcinoma 14.37 10.47 4 47575 74 90580794
Hepatitis cholestatic 14.36 10.47 20 47559 8541 90572327
Renal necrosis 14.32 10.47 4 47575 75 90580793
Microtia 14.31 10.47 6 47573 395 90580473
Mucocutaneous leishmaniasis 14.31 10.47 6 47573 395 90580473
Pneumonia 14.27 10.47 437 47142 637622 89943246
Muscle abscess 14.24 10.47 6 47573 400 90580468
Scleroderma 14.22 10.47 17 47562 6244 90574624
Superinfection bacterial 14.15 10.47 8 47571 1014 90579854
Normocytic anaemia 14.14 10.47 12 47567 2932 90577936
Coxsackie virus test positive 14.13 10.47 3 47576 16 90580852
Hypertriglyceridaemia 14.09 10.47 19 47560 7870 90572998
Brain herniation 14.08 10.47 14 47565 4186 90576682
Injection site bruising 13.95 10.47 5 47574 52302 90528566
Herpes zoster meningoencephalitis 13.95 10.47 6 47573 421 90580447
Autoimmune haemolytic anaemia 13.94 10.47 16 47563 5629 90575239
Chronic obstructive pulmonary disease 13.91 10.47 11 47568 73818 90507050
Urinary tract infection enterococcal 13.89 10.47 12 47567 3004 90577864
Ureteric stenosis 13.88 10.47 7 47572 705 90580163
Bacterial sepsis 13.88 10.47 15 47564 4940 90575928
Fanconi syndrome 13.85 10.47 10 47569 1933 90578935
Oesophagitis 13.81 10.47 29 47550 17220 90563648
Mycobacterium abscessus infection 13.78 10.47 8 47571 1067 90579801
Complement factor decreased 13.72 10.47 4 47575 88 90580780
Staphylococcal infection 13.65 10.47 56 47523 48383 90532485
Skin cancer 13.58 10.47 25 47554 13494 90567374
Acute polyneuropathy 13.51 10.47 6 47573 455 90580413
Torticollis 13.48 10.47 11 47568 2547 90578321
Rash pruritic 13.41 10.47 14 47565 82200 90498668
Encephalitis autoimmune 13.33 10.47 10 47569 2048 90578820
Clear cell renal cell carcinoma 13.29 10.47 9 47570 1571 90579297
Tracheobronchitis 13.26 10.47 9 47570 1576 90579292
Accidental exposure to product 13.24 10.47 3 47576 42363 90538505
Pneumonia serratia 13.19 10.47 3 47576 23 90580845
Bone marrow failure 13.12 10.47 42 47537 32179 90548689
Bone marrow granuloma 13.08 10.47 3 47576 24 90580844
Sterile pyuria 13.08 10.47 3 47576 24 90580844
Genital herpes 13.08 10.47 10 47569 2108 90578760
Antibiotic level above therapeutic 13.06 10.47 6 47573 492 90580376
Fungal skin infection 13.05 10.47 15 47564 5286 90575582
Parvovirus infection 13.05 10.47 6 47573 493 90580375
Viral vasculitis 13.05 10.47 4 47575 105 90580763
Ear pain 13.04 10.47 7 47572 57695 90523173
Post herpetic neuralgia 13.02 10.47 11 47568 2673 90578195
Loss of personal independence in daily activities 12.98 10.47 33 47546 136072 90444796
Disseminated trichosporonosis 12.94 10.47 4 47575 108 90580760
Dyspnoea 12.93 10.47 358 47221 880597 89700271
Lung diffusion test decreased 12.87 10.47 7 47572 824 90580044
Endophthalmitis 12.81 10.47 14 47565 4671 90576197
Leiomyosarcoma metastatic 12.76 10.47 3 47576 27 90580841
Coloboma 12.73 10.47 4 47575 114 90580754
Drug level fluctuating 12.72 10.47 6 47573 523 90580345
Histoplasmosis cutaneous 12.67 10.47 3 47576 28 90580840
Typhoid fever 12.67 10.47 3 47576 28 90580840
Muscle disorder 12.65 10.47 15 47564 5464 90575404
Cardiac sarcoidosis 12.63 10.47 4 47575 117 90580751
Enterocolitis 12.62 10.47 21 47558 10469 90570399
Pneumatosis intestinalis 12.54 10.47 12 47567 3425 90577443
Graft versus host disease in eye 12.54 10.47 4 47575 120 90580748
Nephrostomy 12.51 10.47 4 47575 121 90580747
Rectal haemorrhage 12.50 10.47 15 47564 82729 90498139
Graft versus host disease in lung 12.49 10.47 6 47573 544 90580324
Anorexia nervosa 12.46 10.47 5 47574 294 90580574
Varicella zoster pneumonia 12.41 10.47 4 47575 124 90580744
Sleep disorder due to a general medical condition 12.41 10.47 4 47575 44734 90536134
Neoplasm progression 12.30 10.47 4 47575 44482 90536386
Gastrointestinal disorder 12.23 10.47 196 47383 256491 90324377
Hepatic cyst infection 12.18 10.47 4 47575 132 90580736
Dyspepsia 12.17 10.47 58 47521 198102 90382766
Necrotising herpetic retinopathy 12.09 10.47 4 47575 135 90580733
Retinal haemorrhage 12.04 10.47 15 47564 5749 90575119
Smooth muscle cell neoplasm 11.98 10.47 8 47571 1365 90579503
Cardiac infection 11.97 10.47 6 47573 597 90580271
Feeling hot 11.93 10.47 14 47565 77994 90502874
Coma 11.91 10.47 72 47507 72560 90508308
BRASH syndrome 11.89 10.47 9 47570 1870 90578998
Wrong technique in product usage process 11.88 10.47 12 47567 71559 90509309
Muscular weakness 11.83 10.47 62 47517 206604 90374264
Chest pain 11.82 10.47 109 47470 319536 90261332
Pneumonia klebsiella 11.73 10.47 11 47568 3061 90577807
Oesophageal atresia 11.72 10.47 6 47573 624 90580244
Central nervous system fungal infection 11.71 10.47 4 47575 149 90580719
Laryngitis 11.70 10.47 6 47573 50747 90530121
Infusion site cellulitis 11.70 10.47 5 47574 345 90580523
Monocytosis 11.70 10.47 7 47572 987 90579881
Systemic sclerosis pulmonary 11.69 10.47 3 47576 40 90580828
Pneumocystis jirovecii infection 11.65 10.47 9 47570 1927 90578941
Epstein-Barr virus antibody positive 11.63 10.47 5 47574 350 90580518
Mediastinitis 11.61 10.47 5 47574 352 90580516
Extremity necrosis 11.56 10.47 9 47570 1948 90578920
Prophylaxis against transplant rejection 11.56 10.47 3 47576 42 90580826
Back injury 11.54 10.47 5 47574 46617 90534251
Sarcoma of skin 11.49 10.47 3 47576 43 90580825
Arthritis 11.47 10.47 47 47532 167268 90413600
Gastrointestinal toxicity 11.45 10.47 19 47560 9448 90571420
Dialysis 11.44 10.47 21 47558 11308 90569560
Gastroenteritis eosinophilic 11.37 10.47 4 47575 163 90580705
Cytopenia 11.35 10.47 27 47552 17422 90563446
Antibody test negative 11.30 10.47 3 47576 46 90580822
Pneumomediastinum 11.27 10.47 9 47570 2022 90578846
Papilloedema 11.26 10.47 13 47566 4602 90576266
Ear infection 11.25 10.47 12 47567 69763 90511105
Large intestinal ulcer 11.23 10.47 12 47567 3905 90576963
Liver function test increased 11.18 10.47 17 47562 84838 90496030
Oliguria 11.12 10.47 20 47559 10604 90570264
Myelitis 11.08 10.47 9 47570 2069 90578799
Pulmonary hypertension 11.08 10.47 48 47531 42475 90538393
Lymphocyte count decreased 11.07 10.47 42 47537 35008 90545860
Infective tenosynovitis 11.06 10.47 5 47574 395 90580473
Adenoviral haemorrhagic cystitis 11.06 10.47 4 47575 177 90580691
Gastritis fungal 11.06 10.47 4 47575 177 90580691
Bacterial colitis 10.99 10.47 4 47575 180 90580688
Chronic hepatitis C 10.95 10.47 4 47575 182 90580686
Wound complication 10.93 10.47 13 47566 4750 90576118
Renal abscess 10.92 10.47 7 47572 1114 90579754
Bacterial infection 10.89 10.47 32 47547 23412 90557456
Retroperitoneal haematoma 10.88 10.47 11 47568 3357 90577511
Hyperhidrosis 10.84 10.47 36 47543 136269 90444599
Lymphocytic infiltration 10.84 10.47 7 47572 1129 90579739
Renal infarct 10.80 10.47 8 47571 1607 90579261
Exposure during pregnancy 10.78 10.47 77 47502 238333 90342535
Hypoalbuminaemia 10.78 10.47 25 47554 15872 90564996
Blood lactate dehydrogenase increased 10.74 10.47 34 47545 25898 90554970
Urinary tract infection fungal 10.72 10.47 6 47573 746 90580122
Splenic vein thrombosis 10.68 10.47 5 47574 428 90580440
Plasmodium falciparum infection 10.65 10.47 3 47576 58 90580810
Poikilocytosis 10.61 10.47 4 47575 199 90580669
Lymphorrhoea 10.60 10.47 3 47576 59 90580809
Systemic inflammatory response syndrome 10.60 10.47 15 47564 6501 90574367
Lung abscess 10.59 10.47 9 47570 2204 90578664
Double stranded DNA antibody positive 10.58 10.47 5 47574 437 90580431
Pre-eclampsia 10.56 10.47 20 47559 11028 90569840
Foetal exposure timing unspecified 10.51 10.47 5 47574 444 90580424
Encephalocele 10.48 10.47 4 47575 206 90580662

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Transplant rejection 834.31 12.49 389 54781 13199 42552966
Kidney transplant rejection 817.82 12.49 336 54834 8347 42557818
Cytomegalovirus infection 688.85 12.49 461 54709 31845 42534320
Complications of transplanted kidney 572.55 12.49 227 54943 5123 42561042
Post transplant lymphoproliferative disorder 525.55 12.49 250 54920 8870 42557295
Polyomavirus-associated nephropathy 493.92 12.49 207 54963 5408 42560757
Immunosuppressant drug level increased 359.11 12.49 183 54987 7548 42558617
BK virus infection 312.29 12.49 174 54996 8610 42557555
COVID-19 291.36 12.49 531 54639 115417 42450748
Renal transplant failure 284.09 12.49 97 55073 1408 42564757
Cryptococcosis 254.60 12.49 110 55060 3101 42563064
Transplant dysfunction 237.46 12.49 106 55064 3237 42562928
Cytomegalovirus viraemia 235.26 12.49 154 55016 10223 42555942
Pulmonary nocardiosis 233.40 12.49 88 55082 1724 42564441
Nocardiosis 232.76 12.49 120 55050 5070 42561095
Blood creatinine increased 221.55 12.49 459 54711 109544 42456621
Malacoplakia 220.18 12.49 71 55099 853 42565312
Thrombotic microangiopathy 216.31 12.49 168 55002 14614 42551551
Leukopenia 206.46 12.49 357 54813 74389 42491776
JC virus infection 199.87 12.49 91 55079 2913 42563252
Polyomavirus viraemia 199.67 12.49 82 55088 2030 42564135
West Nile viral infection 192.42 12.49 64 55106 853 42565312
Epstein-Barr virus infection 181.66 12.49 128 55042 9590 42556575
Aspergillus infection 181.26 12.49 156 55014 15681 42550484
Hepatitis E 180.76 12.49 86 55084 3048 42563117
Bronchopulmonary aspergillosis 180.20 12.49 170 55000 19259 42546906
Meningitis cryptococcal 179.97 12.49 87 55083 3196 42562969
Delayed graft function 179.03 12.49 81 55089 2554 42563611
Chronic allograft nephropathy 178.63 12.49 70 55100 1528 42564637
Mucormycosis 159.45 12.49 105 55065 7038 42559127
Enterococcal infection 159.35 12.49 129 55041 11910 42554255
Histoplasmosis disseminated 153.96 12.49 68 55102 2023 42564142
Pseudoaneurysm infection 144.74 12.49 37 55133 175 42565990
Haemophagocytic lymphohistiocytosis 142.05 12.49 145 55025 18077 42548088
Transplant failure 140.70 12.49 79 55091 3965 42562200
Disseminated cryptococcosis 136.59 12.49 61 55109 1864 42564301
Drug level increased 136.51 12.49 169 55001 26031 42540134
Renal tubular atrophy 135.88 12.49 56 55114 1399 42564766
Vascular pseudoaneurysm ruptured 135.35 12.49 42 55128 441 42565724
Pneumonia cryptococcal 130.59 12.49 55 55115 1453 42564712
Acute kidney injury 127.07 12.49 861 54309 366476 42199689
Parvovirus B19 infection 126.42 12.49 56 55114 1678 42564487
Fall 125.59 12.49 74 55096 234446 42331719
Strongyloidiasis 124.76 12.49 69 55101 3362 42562803
Septic shock 121.50 12.49 325 54845 91347 42474818
Focal segmental glomerulosclerosis 120.30 12.49 61 55109 2487 42563678
Escherichia infection 119.85 12.49 107 55063 11289 42554876
Blastomycosis 119.81 12.49 42 55128 662 42565503
Nephropathy toxic 118.73 12.49 127 55043 16711 42549454
Brain abscess 118.17 12.49 72 55098 4212 42561953
Kidney fibrosis 116.49 12.49 61 55109 2661 42563504
Rash 112.15 12.49 116 55054 276838 42289327
Pseudomonas infection 112.10 12.49 120 55050 15803 42550362
Proteinuria 111.38 12.49 143 55027 22840 42543325
Infection reactivation 110.86 12.49 55 55115 2139 42564026
Incision site pain 109.07 12.49 52 55118 1851 42564314
Candida infection 105.57 12.49 135 55035 21475 42544690
Progressive multifocal leukoencephalopathy 105.16 12.49 100 55070 11436 42554729
Klebsiella infection 100.96 12.49 97 55073 11235 42554930
Pruritus 97.62 12.49 62 55108 188709 42377456
Trichodysplasia spinulosa 96.92 12.49 31 55139 362 42565803
Fatigue 95.85 12.49 270 54900 435371 42130794
Phaeohyphomycosis 95.30 12.49 41 55129 1143 42565022
Pain 94.15 12.49 107 55063 244741 42321424
Renal tubular injury 91.08 12.49 45 55125 1734 42564431
Histoplasmosis 90.89 12.49 45 55125 1742 42564423
Cytomegalovirus colitis 90.02 12.49 59 55111 3922 42562243
Renal artery stenosis 88.12 12.49 48 55122 2269 42563896
Renal impairment 85.53 12.49 325 54845 109903 42456262
Constipation 82.94 12.49 54 55116 162237 42403928
Pneumocystis jirovecii pneumonia 82.52 12.49 130 55040 25051 42541114
Dizziness 82.36 12.49 122 55048 249132 42317033
Liver transplant rejection 81.79 12.49 47 55123 2466 42563699
Product use in unapproved indication 80.86 12.49 460 54710 183996 42382169
Malignant neoplasm progression 79.56 12.49 21 55149 108379 42457786
Lymphocele 78.81 12.49 39 55131 1508 42564657
Immune reconstitution inflammatory syndrome 77.74 12.49 80 55090 10063 42556102
Disseminated mucormycosis 76.66 12.49 37 55133 1354 42564811
Cryptosporidiosis infection 75.91 12.49 31 55139 756 42565409
Hydronephrosis 75.84 12.49 85 55085 11780 42554385
COVID-19 pneumonia 75.61 12.49 115 55055 21498 42544667
Off label use 74.58 12.49 1198 53972 637137 41929028
Dyspnoea 73.17 12.49 310 54860 442311 42123854
Anxiety 73.02 12.49 31 55139 118529 42447636
Acute respiratory distress syndrome 71.78 12.49 135 55035 29973 42536192
Febrile neutropenia 70.42 12.49 82 55088 185621 42380544
Depression 70.39 12.49 28 55142 111335 42454830
Arthralgia 70.19 12.49 98 55072 205140 42361025
Scedosporium infection 69.78 12.49 36 55134 1522 42564643
Alternaria infection 69.25 12.49 27 55143 581 42565584
Ureaplasma infection 68.07 12.49 27 55143 609 42565556
Gastroenteritis norovirus 66.37 12.49 36 55134 1687 42564478
Apoptosis 66.36 12.49 26 55144 567 42565598
Squamous cell carcinoma of skin 66.12 12.49 82 55088 12644 42553521
Lymphocyte count decreased 65.44 12.49 124 55046 27685 42538480
Adenovirus infection 63.92 12.49 60 55110 6749 42559416
Drug interaction 63.80 12.49 575 54595 266424 42299741
Drug hypersensitivity 62.79 12.49 25 55145 99364 42466801
Diffuse large B-cell lymphoma 62.61 12.49 69 55101 9385 42556780
Renal tubular necrosis 61.86 12.49 96 55074 18258 42547907
Pneumonia cytomegaloviral 60.57 12.49 47 55123 4079 42562086
Hyperhidrosis 60.15 12.49 21 55149 90491 42475674
Renal transplant 59.91 12.49 38 55132 2387 42563778
Product dose omission issue 59.76 12.49 67 55103 154298 42411867
American trypanosomiasis 59.67 12.49 21 55149 335 42565830
Syncope 59.61 12.49 27 55143 99379 42466786
Somnolence 59.42 12.49 57 55113 141048 42425117
Posterior reversible encephalopathy syndrome 59.34 12.49 78 55092 12743 42553422
Encephalitis viral 59.07 12.49 32 55138 1496 42564669
Acinetobacter infection 59.01 12.49 32 55138 1499 42564666
Graft loss 58.61 12.49 27 55143 888 42565277
Respiratory failure 58.37 12.49 323 54847 127809 42438356
Chronic obstructive pulmonary disease 57.55 12.49 7 55163 63107 42503058
Urinoma 57.41 12.49 19 55151 249 42565916
Viraemia 57.33 12.49 33 55137 1737 42564428
Monkeypox 56.58 12.49 21 55149 393 42565772
Donor specific antibody present 56.54 12.49 17 55153 159 42566006
Ureteric stenosis 56.23 12.49 29 55141 1225 42564940
Heart transplant rejection 56.18 12.49 31 55139 1503 42564662
Papilloma viral infection 54.84 12.49 24 55146 698 42565467
Urinary tract infection 54.74 12.49 264 54906 99020 42467145
Cystitis haemorrhagic 54.72 12.49 57 55113 7272 42558893
Pyelonephritis 54.57 12.49 59 55111 7855 42558310
Intentional overdose 54.34 12.49 3 55167 51453 42514712
Renal graft infection 54.09 12.49 20 55150 370 42565795
Disease recurrence 54.02 12.49 119 55051 29559 42536606
Aplasia pure red cell 53.98 12.49 56 55114 7110 42559055
Intentional product misuse 53.74 12.49 8 55162 61892 42504273
Bacillary angiomatosis 52.81 12.49 17 55153 203 42565962
Multiple organ dysfunction syndrome 52.76 12.49 257 54913 96778 42469387
Histology abnormal 52.44 12.49 19 55151 331 42565834
Rhodococcus infection 52.44 12.49 19 55151 331 42565834
Red blood cells urine positive 52.42 12.49 32 55138 1878 42564287
Cat scratch disease 52.03 12.49 19 55151 339 42565826
Dermatophytosis 51.27 12.49 18 55152 285 42565880
Arterial haemorrhage 51.05 12.49 27 55143 1202 42564963
Visceral leishmaniasis 49.78 12.49 26 55144 1128 42565037
Transitional cell carcinoma 49.64 12.49 35 55135 2623 42563542
Basal cell carcinoma 49.37 12.49 98 55072 22635 42543530
Renal-limited thrombotic microangiopathy 49.14 12.49 17 55153 257 42565908
Smooth muscle cell neoplasm 47.97 12.49 17 55153 277 42565888
Rectal prolapse 46.81 12.49 20 55150 548 42565617
Injection site pain 46.79 12.49 9 55161 57789 42508376
Pulmonary mucormycosis 46.78 12.49 27 55143 1428 42564737
Squamous cell carcinoma 46.71 12.49 70 55100 12912 42553253
Trichophytosis 46.22 12.49 18 55152 386 42565779
Renal cyst haemorrhage 46.21 12.49 21 55149 669 42565496
Human herpesvirus 8 infection 46.07 12.49 27 55143 1470 42564695
Epstein-Barr virus associated lymphoma 45.93 12.49 24 55146 1042 42565123
Asthma 45.84 12.49 12 55158 62302 42503863
Varicella zoster virus infection 45.70 12.49 33 55137 2568 42563597
Lymphopenia 45.68 12.49 92 55078 21471 42544694
Necrotising oesophagitis 45.12 12.49 23 55147 948 42565217
Decreased appetite 45.09 12.49 116 55054 193021 42373144
Acanthamoeba infection 45.04 12.49 19 55151 504 42565661
Disseminated strongyloidiasis 44.90 12.49 19 55151 508 42565657
Epstein-Barr viraemia 44.75 12.49 31 55139 2258 42563907
Graft versus host disease in lung 44.59 12.49 21 55149 727 42565438
Protein urine present 43.10 12.49 45 55125 5756 42560409
Oesophageal ulcer 42.94 12.49 37 55133 3722 42562443
Pain in extremity 42.92 12.49 81 55089 150523 42415642
Erythema 42.33 12.49 47 55123 108746 42457419
Herpes simplex 42.24 12.49 49 55121 7046 42559119
Graft versus host disease in gastrointestinal tract 42.03 12.49 42 55128 5101 42561064
Transplantation complication 41.96 12.49 15 55155 251 42565914
Graft versus host disease in skin 41.56 12.49 42 55128 5170 42560995
Cytomegalovirus infection reactivation 41.26 12.49 61 55109 11117 42555048
Platelet count decreased 40.85 12.49 73 55097 138508 42427657
Escherichia urinary tract infection 40.10 12.49 38 55132 4325 42561840
Central nervous system abscess 39.70 12.49 10 55160 44 42566121
Malacoplakia gastrointestinal 39.38 12.49 13 55157 169 42565996
Glomerulonephritis 39.35 12.49 30 55140 2536 42563629
Trench fever 39.17 12.49 10 55160 47 42566118
Musculoskeletal stiffness 39.06 12.49 13 55157 57752 42508413
Alveolar proteinosis 38.97 12.49 19 55151 711 42565454
Inappropriate schedule of product administration 38.90 12.49 40 55130 95862 42470303
Nausea 38.84 12.49 328 54842 396471 42169694
Hypersensitivity 38.42 12.49 23 55147 72347 42493818
Neutrophil count decreased 38.36 12.49 17 55153 63398 42502767
Fungal infection 38.08 12.49 81 55089 19641 42546524
Acute graft versus host disease 38.05 12.49 50 55120 8165 42558000
Lung transplant rejection 37.91 12.49 21 55149 1026 42565139
Malaise 37.81 12.49 144 55026 212012 42354153
Chronic graft versus host disease in liver 37.06 12.49 18 55152 668 42565497
Cerebral aspergillosis 36.95 12.49 25 55145 1752 42564413
B-cell lymphoma 36.30 12.49 38 55132 4875 42561290
Intraductal papillary mucinous neoplasm 36.25 12.49 16 55154 475 42565690
Muscle spasms 35.92 12.49 35 55135 86009 42480156
Haemolytic uraemic syndrome 35.87 12.49 28 55142 2451 42563714
Pyelonephritis acute 35.66 12.49 28 55142 2472 42563693
Histoplasmosis cutaneous 35.48 12.49 9 55161 41 42566124
Diabetes mellitus 35.45 12.49 163 55007 59924 42506241
Abdominal wall haemorrhage 35.43 12.49 16 55154 502 42565663
Asthenia 35.26 12.49 216 54954 280577 42285588
Hypotension 35.11 12.49 193 54977 257438 42308727
Inflammatory bowel disease 34.87 12.49 32 55138 3497 42562668
Chest pain 34.75 12.49 81 55089 139449 42426716
Disseminated tuberculosis 34.72 12.49 29 55141 2795 42563370
Vena cava injury 34.72 12.49 14 55156 330 42565835
Actinic keratosis 34.66 12.49 38 55132 5138 42561027
Lung transplant 34.63 12.49 27 55143 2359 42563806
Neutrophil count increased 34.46 12.49 78 55092 19726 42546439
Gastroenteritis Escherichia coli 34.23 12.49 19 55151 932 42565233
Epstein-Barr virus associated lymphoproliferative disorder 34.07 12.49 27 55143 2416 42563749
Prophylaxis against transplant rejection 33.85 12.49 9 55161 51 42566114
Wrong technique in product usage process 33.76 12.49 7 55163 42628 42523537
Suicide attempt 33.67 12.49 9 55161 46091 42520074
Postoperative wound infection 33.65 12.49 39 55131 5603 42560562
Pancreas transplant rejection 33.45 12.49 12 55158 203 42565962
Urticaria 33.42 12.49 28 55142 74008 42492157
Graft versus host disease 33.37 12.49 60 55110 12865 42553300
Insomnia 33.33 12.49 64 55106 118189 42447976
Pathogen resistance 33.28 12.49 56 55114 11394 42554771
Chronic graft versus host disease 33.20 12.49 40 55130 5985 42560180
Foetal exposure during pregnancy 33.14 12.49 10 55160 47301 42518864
Osmotic demyelination syndrome 33.13 12.49 19 55151 993 42565172
Joint swelling 32.89 12.49 24 55146 67998 42498167
Lymphadenitis fungal 32.58 12.49 7 55163 12 42566153
SARS-CoV-2 antibody test positive 32.55 12.49 14 55156 390 42565775
Vascular anastomotic haemorrhage 32.50 12.49 13 55157 300 42565865
Norovirus infection 32.28 12.49 17 55153 750 42565415
Gingival hypertrophy 31.98 12.49 26 55144 2413 42563752
Hypoglycaemia 31.80 12.49 19 55151 59835 42506330
Cytomegalovirus gastroenteritis 31.72 12.49 13 55157 320 42565845
Staphylococcal infection 31.66 12.49 114 55056 37529 42528636
Graft ischaemia 31.26 12.49 8 55162 38 42566127
Gastroenteritis sapovirus 31.22 12.49 11 55159 176 42565989
Cardiac failure congestive 31.13 12.49 39 55131 85563 42480602
Perinephric collection 30.94 12.49 11 55159 181 42565984
Back pain 30.92 12.49 88 55082 141688 42424477
Hallucination 30.91 12.49 18 55152 57489 42508676
Myocardial infarction 30.87 12.49 72 55098 123937 42442228
Vascular hyalinosis 30.65 12.49 10 55160 125 42566040
Suicidal ideation 30.59 12.49 12 55158 48149 42518016
Electrocardiogram QT prolonged 30.37 12.49 12 55158 47933 42518232
Anogenital warts 30.11 12.49 16 55154 719 42565446
Coronary artery disease 30.05 12.49 16 55154 53704 42512461
Myopathy toxic 29.99 12.49 16 55154 725 42565440
Postoperative thoracic procedure complication 29.70 12.49 8 55162 48 42566117
Vascular compression 29.61 12.49 13 55157 381 42565784
Encephalitis 29.61 12.49 47 55123 9111 42557054
Cystitis viral 29.53 12.49 19 55151 1223 42564942
Immunosuppressant drug level decreased 29.47 12.49 22 55148 1802 42564363
Neurotoxicity 29.43 12.49 82 55088 23569 42542596
Cytomegalovirus chorioretinitis 29.41 12.49 33 55137 4578 42561587
Meningitis staphylococcal 29.40 12.49 9 55161 90 42566075
Passenger lymphocyte syndrome 29.31 12.49 9 55161 91 42566074
Drug reaction with eosinophilia and systemic symptoms 29.28 12.49 9 55161 42066 42524099
Graft versus host disease in liver 29.27 12.49 21 55149 1618 42564547
Blood urea increased 29.03 12.49 101 55069 32692 42533473
Skin exfoliation 28.72 12.49 9 55161 41544 42524621
Cryptococcal cutaneous infection 28.44 12.49 10 55160 159 42566006
Paraesthesia 28.27 12.49 32 55138 73427 42492738
Urosepsis 28.21 12.49 61 55109 14959 42551206
Herpes simplex meningomyelitis 28.03 12.49 6 55164 10 42566155
Confusional state 27.79 12.49 117 55053 167480 42398685
Parvovirus B19 infection reactivation 27.76 12.49 7 55163 31 42566134
Meningoencephalitis viral 27.56 12.49 10 55160 175 42565990
Glomerulosclerosis 27.52 12.49 16 55154 858 42565307
Graft complication 27.49 12.49 15 55155 711 42565454
Gastroenteritis cryptosporidial 27.41 12.49 11 55159 256 42565909
Hernial eventration 27.29 12.49 8 55162 68 42566097
Neuropathy peripheral 27.10 12.49 57 55113 101796 42464369
Chronic kidney disease 27.01 12.49 127 55043 47114 42519051
Epistaxis 26.95 12.49 28 55142 66798 42499367
Cytokine release syndrome 26.83 12.49 12 55158 44515 42521650
Gastrointestinal mucormycosis 26.50 12.49 12 55158 379 42565786
Human ehrlichiosis 26.45 12.49 13 55157 495 42565670
Aggression 26.45 12.49 12 55158 44151 42522014
Blood pressure decreased 26.40 12.49 22 55148 58310 42507855
Pneumoperitoneum 26.34 12.49 23 55147 2355 42563810
Dysgeusia 26.28 12.49 6 55164 34183 42531982
Infusion related reaction 26.23 12.49 24 55146 60782 42505383
Loss of personal independence in daily activities 26.20 12.49 16 55154 49800 42516365
Seroma 26.17 12.49 14 55156 638 42565527
Eczema 26.16 12.49 6 55164 34080 42532085
Seizure 26.16 12.49 75 55095 120486 42445679
Therapeutic product effect decreased 26.14 12.49 9 55161 39141 42527024
Coronavirus infection 26.13 12.49 33 55137 5181 42560984
International normalised ratio increased 26.00 12.49 15 55155 48153 42518012
Mycobacterial infection 25.99 12.49 24 55146 2644 42563521
Glomerulonephritis membranoproliferative 25.93 12.49 13 55157 517 42565648
Agitation 25.88 12.49 27 55143 64287 42501878
Nasal cavity cancer 25.74 12.49 10 55160 213 42565952
Pneumonia escherichia 25.65 12.49 14 55156 664 42565501
Balance disorder 25.49 12.49 15 55155 47630 42518535
Enterobacter infection 25.41 12.49 25 55145 2979 42563186
Meningoencephalitis amoebic 25.23 12.49 10 55160 225 42565940
Feeling abnormal 25.16 12.49 32 55138 69754 42496411
Ventricular remodelling 25.12 12.49 8 55162 92 42566073
Chronic graft versus host disease in skin 25.12 12.49 19 55151 1587 42564578
Metabolic acidosis 25.11 12.49 133 55037 51725 42514440
Complications of transplanted heart 25.10 12.49 11 55159 321 42565844
Heart rate decreased 25.09 12.49 8 55162 36524 42529641
Cardiac failure 25.04 12.49 64 55106 106792 42459373
Subcapsular renal haematoma 25.04 12.49 13 55157 557 42565608
Bacterial pyelonephritis 24.94 12.49 11 55159 326 42565839
Hyperparathyroidism secondary 24.92 12.49 20 55150 1822 42564343
Blood 25-hydroxycholecalciferol decreased 24.75 12.49 11 55159 332 42565833
Perineal cyst 24.75 12.49 10 55160 237 42565928
Cytomegalovirus oesophagitis 24.72 12.49 13 55157 572 42565593
Infection in an immunocompromised host 24.72 12.49 16 55154 1041 42565124
Infective tenosynovitis 24.66 12.49 8 55162 98 42566067
Hidradenocarcinoma 24.48 12.49 6 55164 23 42566142
Hepatic artery aneurysm 24.47 12.49 7 55163 54 42566111
Peripheral swelling 24.45 12.49 50 55120 90220 42475945
Bacillus infection 24.40 12.49 14 55156 732 42565433
Gait disturbance 24.30 12.49 57 55113 97943 42468222
Cardio-respiratory arrest 24.29 12.49 24 55146 58612 42507553
Retroperitoneal abscess 24.21 12.49 11 55159 350 42565815
Enterovirus infection 24.09 12.49 17 55153 1276 42564889
Bordetella infection 24.07 12.49 9 55161 172 42565993
Mouth ulceration 23.91 12.49 57 55113 14906 42551259
Parvovirus infection 23.87 12.49 12 55158 480 42565685
Renal cyst infection 23.82 12.49 8 55162 110 42566055
Left ventricular hypertrophy 23.73 12.49 43 55127 9276 42556889
Large intestinal ulcer 23.69 12.49 22 55148 2441 42563724
Herpes simplex pneumonia 23.47 12.49 10 55160 272 42565893
Microsporidia infection 23.46 12.49 16 55154 1136 42565029
Blood creatine phosphokinase increased 23.44 12.49 17 55153 48321 42517844
Bacterial sepsis 23.39 12.49 35 55135 6447 42559718
Isosporiasis 23.37 12.49 8 55162 117 42566048
Angioedema 23.25 12.49 13 55157 42464 42523701
Rheumatoid arthritis 23.22 12.49 13 55157 42427 42523738
Complications of transplanted pancreas 23.20 12.49 6 55164 30 42566135
Wheezing 23.18 12.49 22 55148 54759 42511406
Metastatic squamous cell carcinoma 23.12 12.49 13 55157 654 42565511
Drug level fluctuating 22.99 12.49 13 55157 661 42565504
Arthritis 22.85 12.49 13 55157 42052 42524113
Carotid arteriosclerosis 22.76 12.49 21 55149 2311 42563854
Vesicoureteral reflux surgery 22.60 12.49 4 55166 0 42566165
Marginal zone lymphoma 22.59 12.49 8 55162 130 42566035
Granuloma 22.55 12.49 27 55143 4014 42562151
Acute graft versus host disease in skin 22.50 12.49 37 55133 7387 42558778
Urinary tract infection bacterial 22.47 12.49 21 55149 2349 42563816
Cardiogenic shock 22.44 12.49 9 55161 35631 42530534
Aspartate aminotransferase increased 22.41 12.49 41 55129 77122 42489043
Flushing 22.27 12.49 10 55160 37018 42529147
Gastroenteritis astroviral 22.26 12.49 7 55163 77 42566088
Respiratory distress 22.16 12.49 110 55060 41710 42524455
Rectal haemorrhage 22.09 12.49 19 55151 49587 42516578
Leishmaniasis 22.00 12.49 11 55159 435 42565730
Loss of consciousness 21.88 12.49 55 55115 92299 42473866
Pneumonia fungal 21.78 12.49 41 55129 9105 42557060
Legionella infection 21.72 12.49 12 55158 583 42565582
Human polyomavirus infection 21.69 12.49 16 55154 1287 42564878
Acute graft versus host disease in intestine 21.40 12.49 26 55144 3925 42562240
Disseminated mycobacterium avium complex infection 21.36 12.49 9 55161 238 42565927
Central nervous system lymphoma 20.82 12.49 16 55154 1369 42564796
Weight increased 20.73 12.49 71 55099 107912 42458253
Renal artery arteriosclerosis 20.68 12.49 6 55164 49 42566116
Epstein-Barr virus infection reactivation 20.64 12.49 21 55149 2606 42563559
Superinfection bacterial 20.62 12.49 16 55154 1388 42564777
Splenic abscess 20.60 12.49 12 55158 646 42565519
Diverticulum intestinal 20.47 12.49 29 55141 5084 42561081
Gastrointestinal fungal infection 20.37 12.49 9 55161 268 42565897
Diarrhoea 20.35 12.49 758 54412 460091 42106074
Rash pruritic 20.33 12.49 9 55161 33594 42532571
Aortic pseudoaneurysm 20.26 12.49 6 55164 53 42566112
Aortic dilatation 20.23 12.49 17 55153 1652 42564513
Primary hyperaldosteronism 20.19 12.49 8 55162 180 42565985
Mediastinitis 20.07 12.49 14 55156 1031 42565134
Hepatic cytolysis 20.06 12.49 5 55165 26839 42539326
Gastric ulcer haemorrhage, obstructive 20.04 12.49 5 55165 21 42566144
Non-cirrhotic portal hypertension 20.01 12.49 10 55160 395 42565770
Toxic epidermal necrolysis 19.96 12.49 5 55165 26745 42539420
Respiratory arrest 19.92 12.49 6 55164 28418 42537747
Nasopharyngitis 19.92 12.49 50 55120 83946 42482219
Malignant melanoma 19.78 12.49 40 55130 9360 42556805
Fungal skin infection 19.76 12.49 23 55147 3318 42562847
Hypogammaglobulinaemia 19.76 12.49 46 55124 11845 42554320
Diffuse mesangial sclerosis 19.69 12.49 6 55164 59 42566106
Anti-erythropoietin antibody negative 19.59 12.49 8 55162 195 42565970
Cytomegalovirus syndrome 19.37 12.49 7 55163 121 42566044
Dry mouth 19.37 12.49 14 55156 39865 42526300
Double stranded DNA antibody positive 19.29 12.49 8 55162 203 42565962
Infected lymphocele 19.17 12.49 5 55165 26 42566139
Procedural pain 19.15 12.49 30 55140 5749 42560416
Cutaneous nocardiosis 19.04 12.49 8 55162 210 42565955
Rhabdoid tumour 19.01 12.49 5 55165 27 42566138
Hyperkalaemia 18.99 12.49 173 54997 80285 42485880
Muscle abscess 18.96 12.49 13 55157 931 42565234
Ileal ulcer 18.96 12.49 13 55157 931 42565234
Serotonin syndrome 18.96 12.49 5 55165 25840 42540325
Optic discs blurred 18.92 12.49 6 55164 68 42566097
New onset diabetes after transplantation 18.87 12.49 8 55162 215 42565950
Rhabdomyolysis 18.84 12.49 46 55124 77973 42488192
Ejection fraction decreased 18.83 12.49 3 55167 22084 42544081
Prostate cancer 18.81 12.49 18 55152 44625 42521540
Catatonia 18.78 12.49 31 55139 6208 42559957
Acute myocardial infarction 18.64 12.49 29 55141 58136 42508029
Cytomegalovirus nephritis 18.62 12.49 7 55163 136 42566029
Pneumonia pseudomonal 18.42 12.49 27 55143 4882 42561283
Listeriosis 18.41 12.49 15 55155 1396 42564769
Plasmablastic lymphoma 18.36 12.49 11 55159 624 42565541
Post procedural urine leak 18.34 12.49 7 55163 142 42566023
Periostitis 18.33 12.49 9 55161 342 42565823
Anaphylactic shock 18.33 12.49 4 55166 23513 42542652
Hemianopia heteronymous 18.16 12.49 5 55165 33 42566132
Philadelphia positive chronic myeloid leukaemia 18.16 12.49 7 55163 146 42566019
Cardiac disorder 18.09 12.49 22 55148 48910 42517255
Infective aortitis 17.90 12.49 5 55165 35 42566130
Bartonellosis 17.90 12.49 5 55165 35 42566130
Necrotising fasciitis fungal 17.90 12.49 5 55165 35 42566130
Bacteraemia 17.89 12.49 72 55098 24968 42541197
Cytomegalovirus mucocutaneous ulcer 17.77 12.49 6 55164 84 42566081
Contusion 17.60 12.49 17 55153 41968 42524197
Heart rate increased 17.60 12.49 26 55144 53229 42512936
Pneumonia legionella 17.58 12.49 18 55152 2250 42563915
Abdominal wall abscess 17.57 12.49 11 55159 675 42565490
Glomerulonephritis proliferative 17.51 12.49 8 55162 258 42565907
Herpes simplex hepatitis 17.40 12.49 7 55163 164 42566001
Sleep disorder 17.39 12.49 22 55148 48073 42518092
Creatinine urine increased 17.37 12.49 8 55162 263 42565902
Corynebacterium infection 17.36 12.49 12 55158 871 42565294
Hyperparathyroidism 17.35 12.49 14 55156 1285 42564880
Nephrostomy 17.31 12.49 8 55162 265 42565900
Hypothyroidism 17.30 12.49 10 55160 32074 42534091
Eccrine squamous syringometaplasia 17.21 12.49 5 55165 41 42566124
Stomatitis 17.20 12.49 24 55146 50305 42515860
Pulmonary embolism 17.15 12.49 88 55082 119524 42446641
Memory impairment 17.11 12.49 24 55146 50198 42515967
Hepatitis infectious mononucleosis 17.09 12.49 6 55164 95 42566070
Pallor 17.06 12.49 8 55162 28878 42537287
Shock haemorrhagic 17.04 12.49 53 55117 16189 42549976
Therapeutic product effect incomplete 17.00 12.49 42 55128 70897 42495268
Gastrointestinal disorder 16.98 12.49 111 55059 46542 42519623
Angiosarcoma metastatic 16.97 12.49 6 55164 97 42566068
Ureteral catheterisation 16.95 12.49 3 55167 0 42566165
Biliary anastomosis complication 16.92 12.49 6 55164 98 42566067
IgA nephropathy 16.89 12.49 18 55152 2356 42563809
Gastrointestinal injury 16.88 12.49 13 55157 1116 42565049
Stevens-Johnson syndrome 16.83 12.49 4 55166 22174 42543991
Pneumonia viral 16.75 12.49 24 55146 4250 42561915
Atypical mycobacterial infection 16.74 12.49 14 55156 1352 42564813
Tubulointerstitial nephritis 16.72 12.49 83 55087 31465 42534700
Liver transplant 16.72 12.49 19 55151 2672 42563493
Intervertebral disc space narrowing 16.71 12.49 13 55157 1132 42565033
Tuberculosis 16.71 12.49 39 55131 10060 42556105
Hospitalisation 16.62 12.49 158 55012 74172 42491993
Dry skin 16.57 12.49 23 55147 48315 42517850
Disseminated coccidioidomycosis 16.54 12.49 6 55164 105 42566060
Cytomegalovirus gastritis 16.49 12.49 8 55162 296 42565869
Nephropathy 16.48 12.49 31 55139 6880 42559285
Haemoglobinaemia 16.48 12.49 7 55163 189 42565976
Flatulence 16.42 12.49 6 55164 25146 42541019
Bladder spasm 16.30 12.49 13 55157 1174 42564991
Arthropathy 16.28 12.49 9 55161 29588 42536577
Acute pulmonary histoplasmosis 16.27 12.49 7 55163 195 42565970
Incisional hernia 16.25 12.49 14 55156 1408 42564757
General physical health deterioration 16.13 12.49 122 55048 151124 42415041
Acute graft versus host disease in liver 16.02 12.49 16 55154 1942 42564223
Drug resistance 16.01 12.49 87 55083 34161 42532004
Drug level above therapeutic 16.00 12.49 28 55142 5878 42560287
Human herpesvirus 6 infection 15.98 12.49 18 55152 2507 42563658
Extranodal marginal zone B-cell lymphoma (MALT type) 15.91 12.49 8 55162 320 42565845
Product prescribing error 15.79 12.49 7 55163 26105 42540060
Chest discomfort 15.76 12.49 37 55133 63579 42502586
Phaeohyphomycotic brain abscess 15.74 12.49 5 55165 57 42566108
Oxygen saturation decreased 15.73 12.49 38 55132 64649 42501516
Transmission of an infectious agent via transplant 15.63 12.49 4 55166 19 42566146
Urinary fistula 15.61 12.49 6 55164 124 42566041
Pericardial effusion malignant 15.58 12.49 5 55165 59 42566106
Myocarditis infectious 15.58 12.49 5 55165 59 42566106
Granulomatous lymphadenitis 15.52 12.49 7 55163 219 42565946
Gastrointestinal ulcer perforation 15.51 12.49 5 55165 60 42566105
Renal vein thrombosis 15.47 12.49 9 55161 483 42565682
Anorectal varices 15.43 12.49 5 55165 61 42566104
Infective aneurysm 15.41 12.49 12 55158 1047 42565118
White blood cell count decreased 15.39 12.49 82 55088 110314 42455851
Osteomyelitis fungal 15.36 12.49 8 55162 345 42565820
Aortic valve thickening 15.36 12.49 5 55165 62 42566103
Lip swelling 15.35 12.49 3 55167 19050 42547115
Depressed level of consciousness 15.29 12.49 24 55146 47946 42518219
Madarosis 15.24 12.49 9 55161 497 42565668
Hepatosplenomegaly 15.18 12.49 24 55146 4636 42561529
Hot flush 15.16 12.49 5 55165 22346 42543819
Hypoaesthesia 15.10 12.49 45 55125 71418 42494747
Enterocolitis haemorrhagic 15.09 12.49 12 55158 1079 42565086
Gastrointestinal mucosa hyperaemia 15.09 12.49 8 55162 358 42565807
Complications of transplant surgery 15.08 12.49 9 55161 507 42565658
Cutaneous malacoplakia 15.02 12.49 6 55164 138 42566027
Pupillary deformity 15.00 12.49 4 55166 23 42566142
Renal lymphocele 14.94 12.49 5 55165 68 42566097
Cerebral fungal infection 14.90 12.49 8 55162 367 42565798
Argentine haemorrhagic fever 14.85 12.49 4 55166 24 42566141
Cervical spinal cord paralysis 14.85 12.49 4 55166 24 42566141
Hyperglycaemia 14.84 12.49 106 55064 45753 42520412
Hyperammonaemia 14.83 12.49 32 55138 7834 42558331
Pneumatosis intestinalis 14.83 12.49 24 55146 4728 42561437
Propionibacterium infection 14.79 12.49 7 55163 245 42565920
Toxoplasmosis 14.77 12.49 14 55156 1593 42564572
Palpitations 14.74 12.49 27 55143 50770 42515395
Renal tubular acidosis 14.73 12.49 18 55152 2732 42563433
Tachycardia 14.70 12.49 74 55096 101013 42465152
Cardiac autonomic neuropathy 14.68 12.49 5 55165 72 42566093
Cutaneous B-cell lymphoma 14.68 12.49 5 55165 72 42566093
Disseminated varicella zoster vaccine virus infection 14.68 12.49 5 55165 72 42566093
Abnormal behaviour 14.61 12.49 8 55162 26443 42539722
Microangiopathic haemolytic anaemia 14.56 12.49 12 55158 1135 42565030
Thyroid gland abscess 14.55 12.49 5 55165 74 42566091
Kaposi sarcoma inflammatory cytokine syndrome 14.48 12.49 6 55164 152 42566013
Acute respiratory failure 14.48 12.49 93 55077 38765 42527400
Endocarditis staphylococcal 14.46 12.49 10 55160 726 42565439
Herpes zoster 14.45 12.49 93 55077 38784 42527381
Meningitis Escherichia 14.45 12.49 4 55166 27 42566138
Pancreas transplant 14.45 12.49 4 55166 27 42566138
Lethargy 14.44 12.49 24 55146 46866 42519299
Balamuthia infection 14.42 12.49 3 55167 4 42566161
Atypical haemolytic uraemic syndrome 14.41 12.49 9 55161 550 42565615
Retinal artery occlusion 14.38 12.49 16 55154 2199 42563966
Spinal stenosis 14.37 12.49 28 55142 6378 42559787
Adult failure to thrive 14.31 12.49 5 55165 78 42566087
Subdural haematoma 14.31 12.49 6 55164 23132 42543033
Acute sinusitis 14.30 12.49 14 55156 1658 42564507
Neuroendocrine carcinoma of the skin 14.26 12.49 11 55159 946 42565219
Lymphorrhoea 14.25 12.49 5 55165 79 42566086
Headache 14.24 12.49 221 54949 239148 42327017
Overdose 14.22 12.49 79 55091 105185 42460980
C3 glomerulopathy 14.12 12.49 6 55164 162 42566003
Anal squamous cell carcinoma 14.09 12.49 6 55164 163 42566002
Ventricular fibrillation 14.08 12.49 11 55159 30112 42536053
Swollen tongue 13.97 12.49 5 55165 21226 42544939
Obliterative bronchiolitis 13.95 12.49 13 55157 1448 42564717
Bradycardia 13.95 12.49 60 55110 85424 42480741
Intra-abdominal haemorrhage 13.84 12.49 18 55152 2910 42563255
Neuralgia 13.82 12.49 8 55162 25639 42540526
Graft thrombosis 13.81 12.49 7 55163 285 42565880
Epidermodysplasia verruciformis 13.81 12.49 7 55163 285 42565880
Transient ischaemic attack 13.75 12.49 14 55156 33725 42532440
Burning sensation 13.74 12.49 5 55165 21008 42545157
Extravasation of urine 13.67 12.49 3 55167 6 42566159
Oesophageal stenosis 13.66 12.49 15 55155 2031 42564134
Labelled drug-drug interaction issue 13.63 12.49 14 55156 1757 42564408
Dyskinesia 13.57 12.49 8 55162 25382 42540783
Nasal congestion 13.50 12.49 11 55159 29490 42536675
Conjunctival scar 13.50 12.49 7 55163 299 42565866
Metastatic malignant melanoma 13.48 12.49 16 55154 2357 42563808
Injury 13.46 12.49 6 55164 22310 42543855
Pulmonary mass 13.45 12.49 49 55121 16216 42549949
Contraindicated product administered 13.45 12.49 8 55162 25264 42540901
Skin necrosis 13.44 12.49 27 55143 6287 42559878
Post transplant distal limb syndrome 13.43 12.49 8 55162 449 42565716
Nephrosclerosis 13.39 12.49 11 55159 1036 42565129
Proctitis ulcerative 13.35 12.49 6 55164 186 42565979
Stenotrophomonas sepsis 13.32 12.49 6 55164 187 42565978
Chronic kidney disease-mineral and bone disorder 13.30 12.49 8 55162 457 42565708
Complications of transplanted liver 13.29 12.49 7 55163 309 42565856
Acinetobacter bacteraemia 13.26 12.49 6 55164 189 42565976
Sebaceous gland disorder 13.25 12.49 4 55166 38 42566127
Medication error 13.24 12.49 14 55156 33140 42533025
Cutaneous mucormycosis 13.23 12.49 9 55161 636 42565529
Haemodynamic instability 13.19 12.49 41 55129 12516 42553649
Plasma cell myeloma 13.18 12.49 26 55144 47552 42518613
Oxalosis 13.16 12.49 4 55166 39 42566126
Cholangitis 13.15 12.49 37 55133 10690 42555475
Clonal haematopoiesis 13.15 12.49 6 55164 193 42565972
Secondary immunodeficiency 13.11 12.49 10 55160 846 42565319
Erectile dysfunction 13.10 12.49 8 55162 24905 42541260
Psoriasis 13.09 12.49 27 55143 48577 42517588
Bladder cancer 13.08 12.49 3 55167 17044 42549121
Endocarditis viral 13.07 12.49 3 55167 8 42566157
Apallic syndrome 13.06 12.49 7 55163 320 42565845
Campylobacter gastroenteritis 13.05 12.49 11 55159 1074 42565091
Disease progression 13.00 12.49 121 55049 143535 42422630
Polyneuropathy 12.97 12.49 4 55166 18657 42547508
Impaired healing 12.96 12.49 50 55120 17003 42549162
End stage renal disease 12.96 12.49 49 55121 16509 42549656
Ventricular tachycardia 12.89 12.49 12 55158 30148 42536017
Functional gastrointestinal disorder 12.87 12.49 16 55154 2472 42563693
Peritonitis 12.85 12.49 53 55117 18580 42547585
Fusarium infection 12.84 12.49 13 55157 1603 42564562
Urine output decreased 12.84 12.49 37 55133 10836 42555329
Small intestine gangrene 12.81 12.49 3 55167 9 42566156
Infection 12.79 12.49 210 54960 111858 42454307
Myeloma cast nephropathy 12.76 12.49 5 55165 109 42566056
Neck pain 12.76 12.49 12 55158 30002 42536163
Brain compression 12.73 12.49 6 55164 208 42565957
Endocarditis enterococcal 12.72 12.49 5 55165 110 42566055
Drug eruption 12.72 12.49 7 55163 23068 42543097
Pneumonia klebsiella 12.71 12.49 21 55149 4208 42561957
Drug withdrawal syndrome 12.68 12.49 6 55164 21543 42544622
Underdose 12.66 12.49 3 55167 16663 42549502
Nephrotic syndrome 12.64 12.49 32 55138 8686 42557479
Herpes zoster cutaneous disseminated 12.60 12.49 6 55164 213 42565952
Central nervous system lesion 12.59 12.49 30 55140 7840 42558325
Pneumonia proteus 12.57 12.49 3 55167 10 42566155
Type 2 lepra reaction 12.52 12.49 7 55163 348 42565817
Pneumonia aspiration 12.51 12.49 29 55141 50049 42516116
Mean cell volume increased 12.50 12.49 20 55150 3903 42562262

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Transplant rejection 1526.78 10.76 626 93181 23941 110471551
Cytomegalovirus infection 1473.89 10.76 780 93027 53664 110441828
Post transplant lymphoproliferative disorder 1243.37 10.76 476 93331 15137 110480355
Kidney transplant rejection 1172.55 10.76 425 93382 11562 110483930
Complications of transplanted kidney 799.94 10.76 283 93524 7159 110488333
Polyomavirus-associated nephropathy 780.52 10.76 285 93522 7916 110487576
Immunosuppressant drug level increased 621.78 10.76 267 93540 11457 110484035
Cytomegalovirus viraemia 553.66 10.76 280 93527 17484 110478008
Thrombotic microangiopathy 519.43 10.76 318 93489 28831 110466661
COVID-19 517.99 10.76 822 92985 244238 110251254
BK virus infection 514.87 10.76 242 93565 12864 110482628
Leukopenia 410.61 10.76 566 93241 148225 110347267
Blood creatinine increased 386.94 10.76 614 93193 182275 110313217
Renal transplant failure 382.25 10.76 126 93681 2554 110492938
Epstein-Barr virus infection 379.47 10.76 222 93585 18516 110476976
Delayed graft function 379.45 10.76 141 93666 4116 110491376
Nocardiosis 375.72 10.76 164 93643 7322 110488170
Acute kidney injury 373.40 10.76 1285 92522 634145 109861347
Polyomavirus viraemia 365.32 10.76 130 93677 3344 110492148
Cryptococcosis 357.18 10.76 138 93669 4493 110490999
Aspergillus infection 351.27 10.76 237 93570 25379 110470113
Transplant dysfunction 330.88 10.76 155 93652 8173 110487319
Off label use 329.45 10.76 2283 91524 1497902 108997590
Pulmonary nocardiosis 325.03 10.76 111 93696 2518 110492974
Histoplasmosis disseminated 314.34 10.76 120 93687 3779 110491713
Renal impairment 304.04 10.76 561 93246 187884 110307608
Bronchopulmonary aspergillosis 298.54 10.76 228 93579 29635 110465857
Chronic allograft nephropathy 291.40 10.76 97 93710 2029 110493463
Posterior reversible encephalopathy syndrome 283.70 10.76 233 93574 33628 110461864
Malacoplakia 279.87 10.76 83 93724 1169 110494323
West Nile viral infection 279.47 10.76 84 93723 1242 110494250
Haemophagocytic lymphohistiocytosis 272.48 10.76 221 93586 31338 110464154
Parvovirus B19 infection 269.95 10.76 99 93708 2782 110492710
JC virus infection 269.09 10.76 117 93690 5173 110490319
Pain 266.64 10.76 251 93556 954704 109540788
Enterococcal infection 259.28 10.76 180 93627 20186 110475306
Septic shock 246.58 10.76 463 93344 157065 110338427
Multiple organ dysfunction syndrome 245.09 10.76 452 93355 151258 110344234
Pneumocystis jirovecii pneumonia 240.71 10.76 235 93572 42500 110452992
Drug level increased 231.44 10.76 242 93565 47477 110448015
Mucormycosis 231.37 10.76 132 93675 10496 110484996
Escherichia infection 227.49 10.76 177 93630 23639 110471853
Brain abscess 223.48 10.76 111 93696 6663 110488829
Trichodysplasia spinulosa 223.39 10.76 67 93740 983 110494509
Klebsiella infection 222.82 10.76 163 93644 19846 110475646
Blastomycosis 222.49 10.76 68 93739 1067 110494425
Focal segmental glomerulosclerosis 218.44 10.76 94 93713 4051 110491441
Meningitis cryptococcal 215.41 10.76 97 93710 4665 110490827
Disseminated cryptococcosis 215.00 10.76 82 93725 2575 110492917
Phaeohyphomycosis 206.56 10.76 71 93736 1643 110493849
Respiratory failure 200.00 10.76 513 93294 214819 110280673
Drug interaction 198.53 10.76 895 92912 499288 109996204
Product use in unapproved indication 197.78 10.76 827 92980 446550 110048942
Nephropathy toxic 189.23 10.76 169 93638 27309 110468183
Transplant failure 187.86 10.76 93 93714 5542 110489950
Liver transplant rejection 184.23 10.76 82 93725 3836 110491656
Proteinuria 183.50 10.76 197 93610 39821 110455671
Strongyloidiasis 183.37 10.76 88 93719 4898 110490594
Histoplasmosis 182.48 10.76 75 93732 2878 110492614
Rash 179.27 10.76 262 93545 820702 109674790
Cytomegalovirus colitis 179.15 10.76 97 93710 6964 110488528
Acute respiratory distress syndrome 178.59 10.76 223 93584 52975 110442517
Fatigue 178.30 10.76 490 93317 1215468 109280024
Drug hypersensitivity 173.74 10.76 84 93723 454006 110041486
Kidney fibrosis 172.18 10.76 81 93726 4311 110491181
Pseudomonas infection 167.87 10.76 159 93648 27694 110467798
Joint swelling 167.79 10.76 83 93724 442762 110052730
Renal tubular atrophy 165.53 10.76 65 93742 2211 110493281
COVID-19 pneumonia 165.32 10.76 180 93627 36963 110458529
Varicella zoster virus infection 163.01 10.76 88 93719 6280 110489212
Infection reactivation 162.25 10.76 76 93731 4005 110491487
Epstein-Barr viraemia 162.20 10.76 73 93734 3506 110491986
Arthropathy 159.94 10.76 26 93781 287496 110207996
Pseudoaneurysm infection 159.59 10.76 37 93770 179 110495313
Adenovirus infection 158.60 10.76 105 93702 10889 110484603
Hypersensitivity 157.19 10.76 73 93734 403925 110091567
Infusion related reaction 156.01 10.76 64 93743 381098 110114394
Glossodynia 155.22 10.76 8 93799 221996 110273496
Pneumonia cryptococcal 155.17 10.76 64 93743 2478 110493014
Progressive multifocal leukoencephalopathy 149.52 10.76 142 93665 24814 110470678
Apoptosis 148.74 10.76 45 93762 681 110494811
Hand deformity 146.32 10.76 10 93797 218496 110276996
Vascular pseudoaneurysm ruptured 145.56 10.76 42 93765 534 110494958
Incision site pain 145.44 10.76 65 93742 3070 110492422
Disease recurrence 143.70 10.76 215 93592 60569 110434923
Synovitis 143.35 10.76 29 93778 274063 110221429
Candida infection 141.95 10.76 189 93618 47820 110447672
Lymphocele 141.60 10.76 55 93752 1816 110493676
Fall 141.24 10.76 183 93624 603299 109892193
Arthralgia 140.59 10.76 281 93526 779351 109716141
Graft versus host disease in gastrointestinal tract 140.01 10.76 90 93717 8878 110486614
Graft versus host disease in skin 139.26 10.76 87 93720 8167 110487325
Scedosporium infection 136.99 10.76 58 93749 2400 110493092
Pruritus 136.45 10.76 176 93631 581384 109914108
Anti-cyclic citrullinated peptide antibody positive 135.88 10.76 4 93803 181980 110313512
Lupus nephritis 135.37 10.76 70 93737 4575 110490917
Wheezing 133.48 10.76 27 93780 255203 110240289
Diffuse large B-cell lymphoma 132.32 10.76 109 93698 15789 110479703
Dizziness 131.64 10.76 245 93562 697948 109797544
Renal tubular injury 130.15 10.76 60 93747 3048 110492444
Aplasia pure red cell 129.81 10.76 88 93719 9490 110486002
Renal tubular necrosis 129.24 10.76 144 93663 30331 110465161
Central nervous system lupus 128.64 10.76 47 93760 1306 110494186
Anxiety 124.27 10.76 69 93738 345009 110150483
Depression 122.39 10.76 58 93749 317277 110178215
Wound 122.18 10.76 25 93782 234412 110261080
Graft loss 122.08 10.76 45 93762 1283 110494209
Disseminated tuberculosis 120.37 10.76 67 93740 5079 110490413
Duodenal ulcer perforation 119.35 10.76 8 93799 177692 110317800
Ureaplasma infection 118.97 10.76 46 93761 1500 110493992
Stomatitis 112.79 10.76 44 93763 270198 110225294
Cystitis haemorrhagic 110.69 10.76 88 93719 12121 110483371
Cryptosporidiosis infection 109.77 10.76 40 93767 1103 110494389
Hepatitis E 109.64 10.76 60 93747 4399 110491093
Contraindicated product administered 109.41 10.76 37 93770 248230 110247262
Pneumonia cytomegaloviral 109.08 10.76 70 93737 6884 110488608
Disseminated mucormycosis 108.57 10.76 47 93760 2055 110493437
Alopecia 108.52 10.76 90 93717 364663 110130829
Fibromyalgia 108.33 10.76 10 93797 170899 110324593
Musculoskeletal stiffness 108.12 10.76 51 93756 279771 110215721
Oesophageal ulcer 107.53 10.76 73 93734 7891 110487601
Protein urine present 106.74 10.76 84 93723 11400 110484092
Cat scratch disease 106.03 10.76 34 93773 629 110494863
Muscle injury 105.46 10.76 3 93804 140804 110354688
Renal transplant 103.69 10.76 52 93755 3186 110492306
Immune reconstitution inflammatory syndrome 102.32 10.76 95 93712 16131 110479361
Urticaria 102.07 10.76 73 93734 318784 110176708
Papilloma viral infection 101.34 10.76 45 93762 2093 110493399
Discomfort 99.97 10.76 29 93778 214678 110280814
Hydronephrosis 98.74 10.76 104 93703 20561 110474931
Rheumatoid arthritis 98.01 10.76 67 93740 299546 110195946
Malaise 97.92 10.76 271 93536 671548 109823944
Helicobacter infection 97.71 10.76 18 93789 181859 110313633
Bacillary angiomatosis 97.62 10.76 28 93779 348 110495144
Swelling 96.77 10.76 93 93714 350948 110144544
Gastroenteritis norovirus 95.51 10.76 51 93756 3560 110491932
Encephalitis viral 95.43 10.76 48 93759 2959 110492533
Human herpesvirus 6 infection 95.28 10.76 63 93744 6518 110488974
Mobility decreased 95.27 10.76 41 93766 237381 110258111
Central nervous system lymphoma 94.88 10.76 48 93759 2996 110492496
Viraemia 94.83 10.76 53 93754 4049 110491443
Pain in extremity 94.33 10.76 168 93639 486950 110008542
Pericarditis 94.23 10.76 34 93773 219080 110276412
Pathogen resistance 93.60 10.76 94 93713 17578 110477914
Folliculitis 93.56 10.76 15 93792 167638 110327854
Nasopharyngitis 92.77 10.76 119 93688 394242 110101250
Contusion 92.53 10.76 41 93766 233320 110262172
Injury 92.15 10.76 19 93788 177246 110318246
Hepatic enzyme increased 92.01 10.76 82 93725 320810 110174682
Alternaria infection 91.95 10.76 34 93773 978 110494514
Peripheral swelling 91.90 10.76 125 93682 403909 110091583
Epstein-Barr virus associated lymphoma 91.72 10.76 39 93768 1631 110493861
Asthma 91.61 10.76 49 93758 250242 110245250
Constipation 91.59 10.76 101 93706 357685 110137807
Pemphigus 91.08 10.76 34 93773 214536 110280956
Lower respiratory tract infection 88.38 10.76 48 93759 243058 110252434
Rheumatoid factor positive 88.18 10.76 6 93801 131634 110363858
Sepsis 88.04 10.76 526 93281 326820 110168672
Tubulointerstitial nephritis 87.91 10.76 162 93645 54122 110441370
Human ehrlichiosis 87.65 10.76 30 93777 685 110494807
Blister 86.97 10.76 42 93765 227334 110268158
Hypoaesthesia 86.88 10.76 83 93724 314140 110181352
Lymphopenia 86.37 10.76 136 93671 40034 110455458
Diabetes mellitus 86.27 10.76 231 93576 99150 110396342
Osteoarthritis 86.25 10.76 24 93783 182599 110312893
Renal artery stenosis 85.75 10.76 48 93759 3678 110491814
Rhodococcus infection 85.26 10.76 27 93780 479 110495013
Graft versus host disease 85.19 10.76 92 93715 18714 110476778
Therapeutic product effect decreased 84.87 10.76 51 93756 244265 110251227
Herpes simplex hepatitis 84.76 10.76 30 93777 759 110494733
Injection site pain 84.74 10.76 23 93784 177899 110317593
Urinoma 83.67 10.76 23 93784 242 110495250
Squamous cell carcinoma of skin 82.95 10.76 87 93720 17116 110478376
Viral load 82.75 10.76 18 93789 61 110495431
Dry mouth 82.69 10.76 33 93774 199915 110295577
Type 2 diabetes mellitus 82.39 10.76 24 93783 177208 110318284
Cytomegalovirus infection reactivation 81.84 10.76 89 93718 18244 110477248
Lymphocyte count decreased 81.82 10.76 162 93645 57081 110438411
Confusional state 81.72 10.76 172 93635 468508 110026984
Dyspnoea 81.68 10.76 577 93230 1106295 109389197
Heart transplant rejection 81.47 10.76 38 93769 1983 110493509
Irritable bowel syndrome 80.55 10.76 20 93787 164195 110331297
Disseminated strongyloidiasis 80.34 10.76 27 93780 582 110494910
Herpes simplex 80.11 10.76 82 93725 15682 110479810
Pancreas transplant rejection 80.02 10.76 24 93783 352 110495140
Acanthamoeba infection 79.74 10.76 27 93780 596 110494896
Epstein-Barr virus associated lymphoproliferative disorder 79.46 10.76 50 93757 4752 110490740
American trypanosomiasis 79.28 10.76 27 93780 607 110494885
Pyelonephritis 78.65 10.76 102 93705 25148 110470344
Escherichia urinary tract infection 78.40 10.76 82 93725 16080 110479412
Donor specific antibody present 78.20 10.76 24 93783 382 110495110
Rheumatic fever 78.14 10.76 7 93800 122572 110372920
Haemolytic uraemic syndrome 77.75 10.76 50 93757 4935 110490557
Muscle spasms 77.45 10.76 73 93734 278084 110217408
Malignant neoplasm progression 76.93 10.76 26 93781 174541 110320951
Lung transplant rejection 76.89 10.76 36 93771 1895 110493597
Urinary tract infection 75.74 10.76 505 93302 325777 110169715
Chronic kidney disease 75.17 10.76 186 93621 76105 110419387
Glomerulonephritis 75.15 10.76 48 93759 4682 110490810
B-cell lymphoma 74.53 10.76 56 93751 7098 110488394
Pulmonary mucormycosis 73.32 10.76 36 93771 2107 110493385
Human polyomavirus infection 73.00 10.76 34 93773 1768 110493724
Human herpesvirus 8 infection 71.79 10.76 34 93773 1837 110493655
Bursitis 71.65 10.76 12 93795 129906 110365586
Renal-limited thrombotic microangiopathy 71.13 10.76 24 93783 524 110494968
Insomnia 71.00 10.76 123 93684 360467 110135025
Post transplant distal limb syndrome 70.51 10.76 27 93780 857 110494635
Malacoplakia gastrointestinal 70.45 10.76 20 93787 239 110495253
Angiosarcoma 70.24 10.76 24 93783 545 110494947
Fungal infection 69.28 10.76 141 93666 50665 110444827
Psoriatic arthropathy 68.43 10.76 41 93766 196720 110298772
Sleep disorder 68.24 10.76 42 93765 198602 110296890
Renal graft infection 66.49 10.76 25 93782 754 110494738
Red blood cells urine positive 66.39 10.76 46 93761 5139 110490353
Cerebral toxoplasmosis 65.65 10.76 38 93769 3104 110492388
Joint range of motion decreased 65.55 10.76 12 93795 121820 110373672
Intentional overdose 65.25 10.76 16 93791 132485 110363007
Sinusitis 65.23 10.76 94 93713 296594 110198898
Ureteric stenosis 64.29 10.76 30 93777 1567 110493925
Graft versus host disease in lung 64.13 10.76 28 93779 1250 110494242
Injection site erythema 63.94 10.76 4 93803 94172 110401320
Intentional product misuse 63.62 10.76 17 93790 132887 110362605
Neutrophil count increased 63.28 10.76 109 93698 34543 110460949
Squamous cell carcinoma 62.91 10.76 78 93729 18385 110477107
Angiosarcoma metastatic 61.92 10.76 17 93790 178 110495314
Blood urea increased 61.72 10.76 141 93666 54816 110440676
Drug resistance 61.51 10.76 143 93664 56231 110439261
Erythema 61.49 10.76 95 93712 291352 110204140
Obesity 61.34 10.76 11 93796 113340 110382152
Bacteraemia 60.61 10.76 120 93687 42270 110453222
Facet joint syndrome 60.47 10.76 6 93801 96822 110398670
Nausea 60.27 10.76 715 93092 1234975 109260517
Staphylococcal infection 60.11 10.76 162 93645 69782 110425710
Acute graft versus host disease 60.08 10.76 64 93743 12817 110482675
End stage renal disease 59.61 10.76 82 93725 21391 110474101
Diarrhoea 59.55 10.76 1323 92484 1138182 109357310
Paraesthesia 59.42 10.76 89 93718 276432 110219060
Memory impairment 59.27 10.76 48 93759 196896 110298596
Immunosuppressant drug level decreased 59.20 10.76 34 93773 2737 110492755
Weight increased 59.04 10.76 172 93635 419472 110076020
Chronic graft versus host disease 58.92 10.76 55 93752 9402 110486090
Visceral leishmaniasis 58.59 10.76 29 93778 1727 110493765
Acute respiratory failure 58.45 10.76 168 93639 75092 110420400
Drug effective for unapproved indication 58.45 10.76 66 93741 14101 110481391
Dermatophytosis 58.33 10.76 21 93786 559 110494933
Trichophytosis 58.13 10.76 20 93787 464 110495028
Lip dry 58.03 10.76 8 93799 100075 110395417
Biloma 57.61 10.76 17 93790 235 110495257
Anogenital warts 57.37 10.76 25 93782 1111 110494381
Decreased appetite 57.28 10.76 209 93598 475637 110019855
Asthenia 56.84 10.76 347 93460 688652 109806840
Toxoplasmosis 56.82 10.76 35 93772 3204 110492288
Abdominal discomfort 56.45 10.76 160 93647 393698 110101794
Renal cyst haemorrhage 56.28 10.76 22 93785 739 110494753
Alveolar proteinosis 56.15 10.76 27 93780 1509 110493983
Acinetobacter infection 56.13 10.76 36 93771 3537 110491955
Chronic obstructive pulmonary disease 56.11 10.76 12 93795 109146 110386346
Atypical haemolytic uraemic syndrome 56.08 10.76 27 93780 1513 110493979
Nephropathy 56.01 10.76 63 93744 13404 110482088
Norovirus infection 55.96 10.76 31 93776 2328 110493164
Serositis 55.60 10.76 27 93780 1542 110493950
Sleep disorder due to general medical condition, insomnia type 55.57 10.76 11 93796 105632 110389860
Epidermodysplasia verruciformis 55.42 10.76 19 93788 436 110495056
Body mass index abnormal 55.41 10.76 23 93784 905 110494587
Necrotising oesophagitis 55.10 10.76 27 93780 1573 110493919
Enterobacter infection 55.08 10.76 43 93764 5768 110489724
Chromoblastomycosis 54.81 10.76 15 93792 155 110495337
Back pain 54.44 10.76 149 93658 370847 110124645
General physical health deterioration 54.40 10.76 182 93625 425113 110070379
Cystitis viral 54.17 10.76 26 93781 1447 110494045
Ill-defined disorder 54.09 10.76 33 93774 156820 110338672
Encephalitis 53.89 10.76 73 93734 18766 110476726
Mycobacterial infection 53.79 10.76 38 93769 4379 110491113
Hyperhidrosis 53.49 10.76 48 93759 187250 110308242
Cytomegalovirus chorioretinitis 53.40 10.76 46 93761 7082 110488410
Hypogammaglobulinaemia 53.24 10.76 75 93732 20001 110475491
Metabolic acidosis 52.49 10.76 195 93612 99549 110395943
Acarodermatitis 52.45 10.76 28 93779 1953 110493539
Drug ineffective for unapproved indication 52.42 10.76 199 93608 102639 110392853
Actinic keratosis 52.01 10.76 45 93762 6968 110488524
Vaccination failure 51.54 10.76 30 93777 2476 110493016
Pneumonia fungal 51.35 10.76 63 93744 14691 110480801
Transplantation complication 51.17 10.76 18 93789 447 110495045
Monkeypox 51.05 10.76 17 93790 356 110495136
Blood cholesterol increased 50.83 10.76 49 93758 184736 110310756
Cytomegalovirus oesophagitis 50.77 10.76 22 93785 964 110494528
Oesophageal stenosis 50.65 10.76 39 93768 5126 110490366
Glomerulonephritis membranoproliferative 50.53 10.76 21 93786 829 110494663
Gastroenteritis sapovirus 50.46 10.76 15 93792 213 110495279
Swollen joint count increased 50.17 10.76 6 93801 83655 110411837
C-reactive protein abnormal 49.51 10.76 24 93783 129671 110365821
Histoplasmosis cutaneous 49.45 10.76 12 93795 73 110495419
Perinephric collection 49.35 10.76 17 93790 396 110495096
Disseminated mycobacterium avium complex infection 49.27 10.76 18 93789 500 110494992
Mouth ulceration 49.15 10.76 119 93688 48019 110447473
Smooth muscle cell neoplasm 49.06 10.76 24 93783 1393 110494099
Hyperparathyroidism secondary 48.73 10.76 32 93775 3272 110492220
Microsporidia infection 48.71 10.76 24 93783 1415 110494077
Chest pain 48.17 10.76 161 93646 376214 110119278
Product dose omission issue 48.13 10.76 128 93679 321654 110173838
Transitional cell carcinoma 47.44 10.76 31 93776 3144 110492348
Haemoglobin decreased 47.28 10.76 367 93440 248360 110247132
Systemic lupus erythematosus 47.14 10.76 90 93717 254248 110241244
Complications of transplanted heart 47.13 10.76 17 93790 455 110495037
Pyelonephritis acute 46.97 10.76 43 93764 7170 110488322
Gait disturbance 46.87 10.76 104 93703 278104 110217388
Gait inability 46.60 10.76 29 93778 136347 110359145
Hyperkalaemia 46.40 10.76 233 93574 135563 110359929
Oesophageal candidiasis 46.34 10.76 53 93754 11481 110484011
Prophylaxis against transplant rejection 46.27 10.76 12 93795 99 110495393
Nasal cavity cancer 46.02 10.76 15 93792 293 110495199
Disseminated varicella zoster vaccine virus infection 45.97 10.76 13 93794 153 110495339
Cerebral aspergillosis 45.88 10.76 27 93780 2275 110493217
Peripheral venous disease 45.87 10.76 8 93799 84109 110411383
Bacterial sepsis 45.47 10.76 50 93757 10376 110485116
Pancytopenia 45.37 10.76 319 93488 209294 110286198
Neutrophil count decreased 45.23 10.76 23 93784 120918 110374574
Hyperammonaemia 45.17 10.76 57 93750 13675 110481817
Grip strength decreased 45.11 10.76 7 93800 80167 110415325
Organising pneumonia 45.08 10.76 58 93749 14185 110481307
Headache 44.69 10.76 506 93301 881871 109613621
Loss of personal independence in daily activities 44.59 10.76 37 93770 149983 110345509
Musculoskeletal pain 44.28 10.76 54 93753 182969 110312523
Prescribed overdose 44.26 10.76 10 93797 87571 110407921
Graft versus host disease in liver 44.17 10.76 27 93780 2438 110493054
Encephalopathy 43.94 10.76 160 93647 80895 110414597
Emphysematous pyelonephritis 43.77 10.76 17 93790 561 110494931
Neck pain 43.73 10.76 25 93782 123105 110372387
Philadelphia positive chronic myeloid leukaemia 43.58 10.76 13 93794 187 110495305
Mycoplasma infection 43.44 10.76 22 93785 1376 110494116
Injection site reaction 43.38 10.76 11 93796 89059 110406433
Central nervous system abscess 43.37 10.76 10 93797 47 110495445
Trench fever 42.86 10.76 10 93797 50 110495442
Metastatic squamous cell carcinoma 42.78 10.76 18 93789 733 110494759
Butterfly rash 42.48 10.76 25 93782 2106 110493386
Chronic graft versus host disease in liver 42.40 10.76 19 93788 903 110494589
Road traffic accident 42.35 10.76 19 93788 107379 110388113
Glomerulosclerosis 42.34 10.76 21 93786 1256 110494236
Neurotoxicity 41.67 10.76 103 93704 42104 110453388
Cytomegalovirus syndrome 41.35 10.76 14 93793 309 110495183
Bacterial pyelonephritis 41.15 10.76 18 93789 807 110494685
Cytomegalovirus nephritis 41.13 10.76 12 93795 159 110495333
Medication error 40.98 10.76 19 93788 105347 110390145
Gingival hypertrophy 40.94 10.76 32 93775 4299 110491193
Rectal prolapse 40.70 10.76 26 93781 2537 110492955
Vena cava injury 40.17 10.76 14 93793 338 110495154
Distributive shock 40.02 10.76 36 93771 5868 110489624
Herpes simplex oesophagitis 40.00 10.76 15 93792 449 110495043
Feeling abnormal 39.95 10.76 57 93750 180654 110314838
Maternal exposure during pregnancy 39.95 10.76 99 93708 254784 110240708
Respiratory distress 39.94 10.76 139 93668 68735 110426757
Gastrointestinal mucormycosis 39.69 10.76 17 93790 724 110494768
Suicidal ideation 39.65 10.76 15 93792 93922 110401570
Passenger lymphocyte syndrome 39.64 10.76 12 93795 182 110495310
Abdominal pain upper 39.61 10.76 157 93650 348954 110146538
Gastroenteritis cryptosporidial 39.52 10.76 14 93793 355 110495137
Death 39.45 10.76 821 92986 698048 109797444
Lung transplant 39.37 10.76 34 93773 5252 110490240
Urinary tract infection bacterial 39.25 10.76 41 93766 8026 110487466
Electrocardiogram QT prolonged 38.87 10.76 22 93785 108938 110386554
Febrile neutropenia 38.83 10.76 138 93669 316629 110178863
Gastroenteritis Escherichia coli 38.82 10.76 20 93787 1297 110494195
Graft complication 38.68 10.76 19 93788 1113 110494379
Coronavirus infection 38.59 10.76 44 93763 9501 110485991
Histology abnormal 38.32 10.76 14 93793 389 110495103
Mycobacterium avium complex infection 38.20 10.76 35 93772 5842 110489650
Stress 37.98 10.76 21 93786 105327 110390165
Cryptococcal cutaneous infection 37.93 10.76 13 93794 298 110495194
SARS-CoV-2 antibody test positive 37.92 10.76 14 93793 401 110495091
Vascular anastomotic haemorrhage 37.85 10.76 13 93794 300 110495192
Arterial haemorrhage 37.81 10.76 29 93778 3790 110491702
Systemic mycosis 37.74 10.76 29 93778 3800 110491692
Pancreatitis haemorrhagic 37.57 10.76 18 93789 998 110494494
Coccidioidomycosis 37.43 10.76 21 93786 1616 110493876
Fungal skin infection 37.36 10.76 38 93769 7211 110488281
Complications of transplanted lung 37.36 10.76 16 93791 681 110494811
Intraductal papillary mucinous neoplasm 37.28 10.76 17 93790 842 110494650
Superinfection bacterial 37.24 10.76 24 93783 2377 110493115
Biopsy lung abnormal 37.15 10.76 11 93796 154 110495338
Live birth 37.04 10.76 7 93800 69477 110426015
Urosepsis 37.02 10.76 81 93726 30594 110464898
Urinary fistula 36.84 10.76 10 93797 100 110495392
Exposure during pregnancy 36.82 10.76 53 93754 167371 110328121
Wrong technique in product usage process 36.78 10.76 14 93793 87334 110408158
Pneumoperitoneum 36.72 10.76 29 93778 3955 110491537
Shock haemorrhagic 36.41 10.76 75 93732 27172 110468320
Cytomegalovirus hepatitis 36.41 10.76 17 93790 889 110494603
Hepatitis C 36.39 10.76 49 93758 12524 110482968
Rectal haemorrhage 36.30 10.76 29 93778 119804 110375688
Drug ineffective 36.25 10.76 1605 92202 1518935 108976557
Abdominal wall haemorrhage 36.17 10.76 16 93791 737 110494755
Lymphadenitis fungal 35.94 10.76 8 93799 31 110495461
Oedematous kidney 35.74 10.76 12 93795 258 110495234
Hernial eventration 35.63 10.76 9 93798 66 110495426
Syncope 35.52 10.76 74 93733 202462 110293030
Renal failure 35.43 10.76 320 93487 226254 110269238
Drug level fluctuating 35.02 10.76 17 93790 970 110494522
Arthritis 34.97 10.76 55 93752 167531 110327961
Large intestinal ulcer 34.92 10.76 33 93774 5728 110489764
Balance disorder 34.33 10.76 29 93778 116531 110378961
Pneumonia pseudomonal 34.32 10.76 37 93770 7509 110487983
Anal squamous cell carcinoma 34.28 10.76 16 93791 836 110494656
Infection in an immunocompromised host 34.25 10.76 21 93786 1906 110493586
Malacoplakia vesicae 34.10 10.76 9 93798 80 110495412
Obliterative bronchiolitis 34.10 10.76 27 93780 3696 110491796
New onset diabetes after transplantation 34.09 10.76 13 93794 408 110495084
Muscle abscess 34.01 10.76 19 93788 1450 110494042
Haematuria 33.89 10.76 150 93657 82855 110412637
Inflammatory bowel disease 33.84 10.76 36 93771 7198 110488294
Listeriosis 33.78 10.76 24 93783 2790 110492702
Deep vein thrombosis postoperative 33.76 10.76 5 93802 59286 110436206
Neuroendocrine carcinoma of the skin 33.55 10.76 20 93787 1725 110493767
Liver abscess 33.55 10.76 37 93770 7702 110487790
Migraine 33.35 10.76 59 93748 171593 110323899
Liver disorder 33.32 10.76 43 93764 142200 110353292
Septic embolus 33.03 10.76 22 93785 2304 110493188
Left ventricular hypertrophy 32.95 10.76 48 93759 13196 110482296
Osmotic demyelination syndrome 32.94 10.76 21 93786 2042 110493450
Meningoencephalitis amoebic 32.91 10.76 11 93796 233 110495259
Acute graft versus host disease in skin 32.84 10.76 43 93764 10697 110484795
Parvovirus infection 32.61 10.76 16 93791 935 110494557
Endocarditis 32.60 10.76 48 93759 13323 110482169
Disseminated coccidioidomycosis 32.39 10.76 11 93796 245 110495247
Balamuthia infection 32.22 10.76 9 93798 101 110495391
Heart rate decreased 32.07 10.76 15 93792 82741 110412751
Cardiac failure congestive 32.04 10.76 49 93758 150951 110344541
Rash pruritic 31.95 10.76 22 93785 98047 110397445
Infective tenosynovitis 31.75 10.76 13 93794 494 110494998
Knee arthroplasty 31.67 10.76 8 93799 64940 110430552
Steroid diabetes 31.66 10.76 30 93777 5224 110490268
Product quality issue 31.55 10.76 13 93794 77286 110418206
Eczema 31.44 10.76 11 93796 72282 110423210
Shock 30.94 10.76 108 93699 53480 110442012
Acute pulmonary histoplasmosis 30.79 10.76 11 93796 286 110495206
Double stranded DNA antibody positive 30.68 10.76 13 93794 539 110494953
Systemic candida 30.61 10.76 40 93767 9934 110485558
Herpes simplex meningomyelitis 30.56 10.76 6 93801 10 110495482
Mycobacterium haemophilum infection 30.48 10.76 14 93793 705 110494787
Renal lymphocele 30.46 10.76 9 93798 125 110495367
Inappropriate schedule of product administration 30.44 10.76 81 93726 203556 110291936
Impaired healing 30.36 10.76 77 93730 196640 110298852
Cytomegalovirus gastroenteritis 30.35 10.76 14 93793 712 110494780
Parvovirus B19 infection reactivation 30.34 10.76 7 93800 33 110495459
Ileal ulcer 30.27 10.76 19 93788 1798 110493694
Cutaneous nocardiosis 30.06 10.76 11 93796 307 110495185
Tuberculosis 29.98 10.76 54 93753 17720 110477772
Injection site pruritus 29.94 10.76 4 93803 51254 110444238
Necrotising retinitis 29.93 10.76 18 93789 1578 110493914
Ventricular remodelling 29.70 10.76 9 93798 137 110495355
Escherichia sepsis 29.68 10.76 40 93767 10232 110485260
Infectious pleural effusion 29.62 10.76 28 93779 4863 110490629
Escherichia pyelonephritis 29.41 10.76 15 93792 952 110494540
Cytomegalovirus test positive 29.40 10.76 33 93774 7003 110488489
Serotonin syndrome 29.40 10.76 7 93800 59146 110436346
Vascular compression 29.38 10.76 14 93793 767 110494725
Mediastinitis 29.34 10.76 17 93790 1391 110494101
Calciphylaxis 29.31 10.76 26 93781 4161 110491331
Psoriasis 29.15 10.76 46 93761 139947 110355545
Bordetella infection 29.15 10.76 10 93797 230 110495262
Meningitis staphylococcal 29.11 10.76 10 93797 231 110495261
Therapy change 28.99 10.76 39 93768 9958 110485534
Perineal cyst 28.99 10.76 10 93797 234 110495258
Suicide attempt 28.91 10.76 27 93780 103367 110392125
Azotaemia 28.73 10.76 39 93768 10046 110485446
Periostitis 28.68 10.76 14 93793 809 110494683
Chronic graft versus host disease in skin 28.40 10.76 21 93786 2598 110492894
Leishmaniasis 28.33 10.76 12 93795 497 110494995
Ureteral necrosis 28.07 10.76 8 93799 97 110495395
Herpes simplex pneumonia 27.80 10.76 11 93796 382 110495110
Biliary anastomosis complication 27.75 10.76 9 93798 173 110495319
Renal cyst infection 27.71 10.76 10 93797 268 110495224
Feeling hot 27.66 10.76 22 93785 91084 110404408
Peptostreptococcus infection 27.65 10.76 9 93798 175 110495317
Pulmonary alveolar haemorrhage 27.56 10.76 56 93751 20094 110475398
Meningoencephalitis viral 27.54 10.76 12 93795 533 110494959
Pregnancy 27.53 10.76 5 93802 51062 110444430
Transmission of an infectious agent via transplant 27.43 10.76 6 93801 21 110495471
Enterovirus infection 27.35 10.76 21 93786 2749 110492743
Cytomegalovirus gastrointestinal infection 27.30 10.76 13 93794 711 110494781
Hidradenocarcinoma 27.01 10.76 6 93801 23 110495469
Perinephric abscess 26.91 10.76 11 93796 416 110495076
Respiratory arrest 26.89 10.76 8 93799 58291 110437201
Skin exfoliation 26.82 10.76 21 93786 87630 110407862
Chemical peritonitis 26.81 10.76 10 93797 295 110495197
Myocardial infarction 26.78 10.76 79 93728 192004 110303488
Muscular weakness 26.76 10.76 114 93693 248354 110247138
Drug dependence 26.75 10.76 5 93802 50015 110445477
Autoimmune disorder 26.74 10.76 11 93796 65472 110430020
Eye infection toxoplasmal 26.70 10.76 13 93794 747 110494745
Pneumonia legionella 26.67 10.76 23 93784 3546 110491946
Amnesia 26.67 10.76 30 93777 105378 110390114
Subcapsular renal haematoma 26.56 10.76 14 93793 952 110494540
Squamous cell carcinoma of the cervix 26.34 10.76 10 93797 310 110495182
Acute graft versus host disease in intestine 26.26 10.76 28 93779 5611 110489881
Tuberculoma of central nervous system 26.11 10.76 12 93795 605 110494887
Pneumonia escherichia 26.10 10.76 15 93792 1209 110494283
Night sweats 26.07 10.76 46 93761 133937 110361555
Drug intolerance 26.04 10.76 220 93587 406292 110089200
Obstructive airways disorder 26.03 10.76 4 93803 46145 110449347
Haemodynamic instability 26.00 10.76 59 93748 22829 110472663
Renal artery arteriosclerosis 25.97 10.76 7 93800 68 110495424
Pneumatosis intestinalis 25.85 10.76 34 93773 8495 110486997
Hypotension 25.83 10.76 302 93505 523547 109971945
Toxic epidermal necrolysis 25.77 10.76 8 93799 56719 110438773
Lower limb fracture 25.77 10.76 16 93791 75332 110420160
Blood 25-hydroxycholecalciferol decreased 25.76 10.76 11 93796 465 110495027
Onychomadesis 25.66 10.76 4 93803 45659 110449833
Transplant 25.54 10.76 15 93792 1259 110494233
Transplantation associated food allergy 25.52 10.76 8 93799 137 110495355
Carotid arteriosclerosis 25.52 10.76 21 93786 3036 110492456
Hallucination 25.52 10.76 29 93778 101403 110394089
Peritonitis 25.52 10.76 73 93734 32534 110462958
Somnolence 25.42 10.76 148 93659 297301 110198191
Cardiac valve abscess 25.42 10.76 8 93799 139 110495353
Meningitis histoplasma 25.39 10.76 6 93801 32 110495460
Graft ischaemia 25.26 10.76 8 93799 142 110495350
Postoperative thoracic procedure complication 25.18 10.76 7 93800 77 110495415
Glomerulonephritis proliferative 25.15 10.76 11 93796 493 110494999
Marginal zone lymphoma 25.12 10.76 9 93798 236 110495256
Loss of consciousness 25.07 10.76 84 93723 196222 110299270
Hypercholesterolaemia 25.07 10.76 24 93783 90813 110404679
Bacterial infection 25.05 10.76 91 93716 45945 110449547
Swollen tongue 24.88 10.76 10 93797 60352 110435140
Pneumopericardium 24.84 10.76 9 93798 244 110495248
IgA nephropathy 24.84 10.76 21 93786 3152 110492340
Back injury 24.79 10.76 5 93802 47394 110448098
Chronic hepatitis C 24.65 10.76 12 93795 689 110494803
Genital herpes simplex 24.58 10.76 11 93796 521 110494971
Oliguria 24.51 10.76 51 93756 18606 110476886
Salmonellosis 24.44 10.76 18 93789 2213 110493279
Fungal sepsis 24.40 10.76 18 93789 2219 110493273
Adverse event 24.36 10.76 34 93773 108775 110386717
Microangiopathic haemolytic anaemia 24.32 10.76 17 93790 1926 110493566
Sleep disorder due to a general medical condition 24.31 10.76 7 93800 52105 110443387
Lupus-like syndrome 24.27 10.76 3 93804 40789 110454703
Complications of transplanted pancreas 24.12 10.76 6 93801 41 110495451
Chorioretinitis 24.08 10.76 15 93792 1400 110494092
Palpitations 24.04 10.76 63 93744 159149 110336343
Epstein-Barr virus infection reactivation 24.01 10.76 23 93784 4061 110491431
Hepatic artery aneurysm 23.98 10.76 7 93800 93 110495399
C3 glomerulopathy 23.96 10.76 8 93799 169 110495323
SARS-CoV-2 antibody test negative 23.94 10.76 10 93797 400 110495092
Legionella infection 23.88 10.76 13 93794 943 110494549
Haemolytic anaemia 23.85 10.76 54 93753 20866 110474626
Injection site bruising 23.71 10.76 7 93800 51256 110444236
Mycobacterium marinum infection 23.66 10.76 12 93795 753 110494739
Hepatic artery stenosis 23.64 10.76 9 93798 281 110495211
Full blood count abnormal 23.57 10.76 9 93798 56043 110439449
Paraspinal abscess 23.57 10.76 10 93797 416 110495076
Liver transplant 23.55 10.76 24 93783 4565 110490927
Prescribed underdose 23.48 10.76 13 93794 65161 110430331
Complications of transplant surgery 23.45 10.76 12 93795 767 110494725
Gastrointestinal fungal infection 23.45 10.76 12 93795 767 110494725
Hip arthroplasty 23.41 10.76 9 93798 55804 110439688
Hypoglycaemia 23.38 10.76 39 93768 116065 110379427
Ear infection 23.35 10.76 12 93795 62720 110432772
Splenic abscess 23.33 10.76 13 93794 987 110494505
Lip swelling 23.28 10.76 7 93800 50660 110444832
Isosporiasis 23.24 10.76 8 93799 186 110495306
Retroperitoneal abscess 23.21 10.76 11 93796 595 110494897
Angiocentric lymphoma 23.12 10.76 14 93793 1243 110494249
Intracranial pressure increased 23.10 10.76 36 93771 10499 110484993
Hepatic angiosarcoma 22.95 10.76 7 93800 109 110495383
Colitis 22.88 10.76 157 93650 102166 110393326
Blood pressure decreased 22.86 10.76 39 93768 115052 110380440
Fungaemia 22.84 10.76 27 93780 6059 110489433
Opportunistic infection 22.83 10.76 21 93786 3522 110491970
Glomerular filtration rate decreased 22.83 10.76 65 93742 28891 110466601
Accidental exposure to product 22.81 10.76 7 93800 50001 110445491
Dry skin 22.77 10.76 35 93772 107618 110387874
Anti-erythropoietin antibody negative 22.76 10.76 9 93798 312 110495180
Epilepsy 22.75 10.76 31 93776 100178 110395314
Hepatic fibrosis 22.68 10.76 31 93776 8035 110487457
Pyelonephritis fungal 22.62 10.76 9 93798 317 110495175
Cytokine release syndrome 22.60 10.76 16 93791 70290 110425202
Pneumonia klebsiella 22.57 10.76 28 93779 6604 110488888
Pneumocystis jirovecii infection 22.56 10.76 23 93784 4377 110491115
Leukocytosis 22.52 10.76 98 93709 53730 110441762
Disseminated toxoplasmosis 22.48 10.76 10 93797 467 110495025
Solid organ transplant rejection 22.48 10.76 6 93801 56 110495436
Myopathy toxic 22.44 10.76 14 93793 1311 110494181
Herpes zoster meningoencephalitis 22.42 10.76 13 93794 1065 110494427
Klebsiella bacteraemia 22.37 10.76 24 93783 4845 110490647
Bacillus infection 22.28 10.76 15 93792 1599 110493893
X-ray abnormal 22.21 10.76 3 93804 38114 110457378
Flushing 22.20 10.76 34 93773 104702 110390790
Gastric ulcer haemorrhage, obstructive 22.14 10.76 5 93802 21 110495471
Product use issue 22.13 10.76 164 93643 311531 110183961
Aortic dilatation 22.11 10.76 17 93790 2229 110493263
Vomiting 22.07 10.76 596 93211 910079 109585413
Haemoperitoneum 22.06 10.76 25 93782 5363 110490129
Stenotrophomonas infection 22.00 10.76 26 93781 5832 110489660
Abdominal abscess 21.99 10.76 32 93775 8787 110486705
Joint tuberculosis 21.94 10.76 8 93799 221 110495271
Mastitis bacterial 21.93 10.76 6 93801 62 110495430
Drug level above therapeutic 21.88 10.76 37 93770 11551 110483941
Complications of transplanted liver 21.80 10.76 10 93797 502 110494990
Hyperglycaemia 21.73 10.76 135 93672 84955 110410537
Hypothyroidism 21.63 10.76 18 93789 72881 110422611
Hospitalisation 21.62 10.76 200 93607 142293 110353199
Oedema 21.60 10.76 98 93709 209878 110285614
Immunosuppression 21.55 10.76 47 93760 17712 110477780
Delusional disorder, erotomanic type 21.50 10.76 6 93801 67 110495425
Secondary immunodeficiency 21.39 10.76 23 93784 4653 110490839
Acute graft versus host disease in liver 21.38 10.76 17 93790 2342 110493150
Optic discs blurred 21.27 10.76 6 93801 70 110495422
Hot flush 21.26 10.76 15 93792 66021 110429471
Renal tubular acidosis 21.24 10.76 23 93784 4692 110490800
Inflammation 21.21 10.76 88 93719 193150 110302342
Phaeohyphomycotic brain abscess 21.19 10.76 6 93801 71 110495421
Urinary tract candidiasis 21.14 10.76 13 93794 1186 110494306
Clostridium difficile infection 21.12 10.76 94 93713 52035 110443457
Rhabdoid tumour 21.11 10.76 5 93802 27 110495465
Diabetic macroangiopathy 21.09 10.76 7 93800 145 110495347
Aggression 21.05 10.76 12 93795 59198 110436294
Meningitis bacterial 21.00 10.76 19 93788 3120 110492372
Diffuse mesangial sclerosis 20.96 10.76 6 93801 74 110495418
Therapeutic product effect incomplete 20.96 10.76 108 93699 223697 110271795
Infective aneurysm 20.92 10.76 14 93793 1478 110494014
Spindle cell sarcoma 20.83 10.76 8 93799 256 110495236
Nephrotic syndrome 20.80 10.76 40 93767 13791 110481701
Pallor 20.72 10.76 11 93796 56456 110439036
Nosocomial infection 20.69 10.76 19 93788 3180 110492312
Hypervolaemia 20.66 10.76 90 93717 49370 110446122
Postoperative wound infection 20.62 10.76 43 93764 15710 110479782
Liver function test increased 20.50 10.76 27 93780 88521 110406971
Diffuse alveolar damage 20.47 10.76 21 93786 4026 110491466
Catheter site abscess 20.43 10.76 8 93799 270 110495222
Primary hyperaldosteronism 20.37 10.76 8 93799 272 110495220
Infective aortitis 20.33 10.76 6 93801 83 110495409
Dyspepsia 20.32 10.76 88 93719 190877 110304615
Porocarcinoma 20.25 10.76 5 93802 33 110495459
Urine protein/creatinine ratio increased 20.24 10.76 14 93793 1559 110493933
Drug level decreased 20.17 10.76 47 93760 18501 110476991
Eccrine squamous syringometaplasia 20.12 10.76 5 93802 34 110495458
Orthostatic hypotension 20.10 10.76 16 93791 66233 110429259
Clostridium difficile colitis 20.10 10.76 82 93725 43696 110451796
Palmar-plantar erythrodysaesthesia syndrome 20.10 10.76 5 93802 41020 110454472
Intervertebral disc space narrowing 20.10 10.76 15 93792 1881 110493611
Hepatosplenomegaly 20.08 10.76 27 93780 6892 110488600
Agitation 20.07 10.76 41 93766 113010 110382482
Cutaneous malacoplakia 20.05 10.76 7 93800 170 110495322
Tuberculosis gastrointestinal 20.04 10.76 10 93797 606 110494886
Aortic pseudoaneurysm 19.94 10.76 6 93801 89 110495403
Dysgeusia 19.89 10.76 18 93789 69967 110425525
Vasogenic cerebral oedema 19.88 10.76 16 93791 2242 110493250
Necrotising fasciitis fungal 19.76 10.76 5 93802 37 110495455
Chronic kidney disease-mineral and bone disorder 19.71 10.76 10 93797 628 110494864
Metastatic malignant melanoma 19.66 10.76 19 93788 3390 110492102
Frequent bowel movements 19.54 10.76 19 93788 71371 110424121
Chronic myeloid leukaemia 19.52 10.76 21 93786 4252 110491240
Bile duct stenosis 19.50 10.76 17 93790 2659 110492833
Mycobacterium chelonae infection 19.46 10.76 18 93789 3042 110492450
Liver injury 19.45 10.76 64 93743 150349 110345143
Periumbilical abscess 19.39 10.76 8 93799 310 110495182
Venoocclusive liver disease 19.32 10.76 41 93766 15166 110480326
Human herpesvirus 6 infection reactivation 19.30 10.76 12 93795 1117 110494375
Orthobunyavirus test positive 19.29 10.76 4 93803 10 110495482
Intentional product use issue 19.28 10.76 127 93680 247779 110247713
Atypical mycobacterial infection 19.27 10.76 17 93790 2701 110492791
Mycobacterium abscessus infection 19.22 10.76 14 93793 1692 110493800
Joint dislocation 19.20 10.76 3 93804 34187 110461305
Bartonellosis 19.20 10.76 5 93802 42 110495450
Emotional distress 19.20 10.76 7 93800 44840 110450652
Bilirubin conjugated increased 19.16 10.76 25 93782 6199 110489293
Overdose 19.09 10.76 118 93689 233676 110261816
Amaurosis fugax 19.08 10.76 16 93791 2374 110493118
Gastroenteritis astroviral 19.07 10.76 7 93800 197 110495295
Drug reaction with eosinophilia and systemic symptoms 19.04 10.76 25 93782 82070 110413422
Cognitive disorder 18.94 10.76 28 93779 87483 110408009
Depressed level of consciousness 18.87 10.76 42 93765 112236 110383256
Granuloma 18.85 10.76 31 93776 9459 110486033
Pulmonary mass 18.85 10.76 72 93735 37229 110458263
Rhinovirus infection 18.85 10.76 35 93772 11754 110483738
Dermatitis papillaris capillitii 18.76 10.76 4 93803 12 110495480
Pneumonia necrotising 18.72 10.76 14 93793 1761 110493731
Aspartate aminotransferase increased 18.71 10.76 71 93736 159865 110335627
Catatonia 18.64 10.76 34 93773 11266 110484226
Ear pain 18.62 10.76 11 93796 53215 110442277
Graft thrombosis 18.62 10.76 9 93798 509 110494983
Escherichia bacteraemia 18.59 10.76 32 93775 10132 110485360
Vitritis infective 18.51 10.76 5 93802 49 110495443
Encephalomalacia 18.47 10.76 13 93794 1489 110494003
Platelet count decreased 18.46 10.76 117 93690 230326 110265166
Vaginal lesion 18.26 10.76 8 93799 360 110495132
Klebsiella sepsis 18.25 10.76 20 93787 4133 110491359
Vesicoureteral reflux surgery 18.22 10.76 3 93804 0 110495492
Anaphylactic reaction 18.21 10.76 44 93763 114256 110381236
Inflammatory myofibroblastic tumour 18.14 10.76 7 93800 227 110495265
Angioedema 18.11 10.76 35 93772 98465 110397027
Argentine haemorrhagic fever 18.07 10.76 4 93803 15 110495477
Anaemia 18.05 10.76 599 93208 546487 109949005
Endophthalmitis 17.99 10.76 28 93779 8159 110487333
Osteomyelitis 17.97 10.76 70 93737 36530 110458962
Disseminated varicella zoster virus infection 17.91 10.76 12 93795 1269 110494223
Hyperparathyroidism 17.89 10.76 19 93788 3791 110491701
Oropharyngeal pain 17.88 10.76 57 93750 135219 110360273
Encephalitis cytomegalovirus 17.81 10.76 14 93793 1896 110493596
Neutrophil Pelger-Huet anomaly present 17.68 10.76 8 93799 389 110495103
International normalised ratio increased 17.60 10.76 29 93778 86743 110408749
Systemic bacterial infection 17.59 10.76 5 93802 60 110495432
Colon injury 17.57 10.76 8 93799 395 110495097
Oesophagitis 17.56 10.76 59 93748 28656 110466836
Transient ischaemic attack 17.55 10.76 17 93790 63965 110431527
Epstein-Barr virus test positive 17.53 10.76 12 93795 1314 110494178
Sneezing 17.53 10.76 3 93804 31981 110463511
Visual impairment 17.52 10.76 57 93750 134371 110361121
Laryngitis 17.52 10.76 7 93800 42404 110453088
Therapy cessation 17.51 10.76 80 93727 44777 110450715
Plasmablastic lymphoma 17.47 10.76 10 93797 800 110494692
Hypertension 17.45 10.76 316 93491 509768 109985724
Gastrointestinal ulcer perforation 17.37 10.76 5 93802 63 110495429
Chest discomfort 17.37 10.76 82 93725 173766 110321726
Plasmapheresis 17.31 10.76 10 93797 814 110494678
Corynebacterium infection 17.24 10.76 14 93793 1986 110493506
Cytomegalovirus mucocutaneous ulcer 17.21 10.76 6 93801 145 110495347
Papilloedema 17.21 10.76 26 93781 7383 110488109
Osteomyelitis fungal 17.16 10.76 8 93799 417 110495075
Anorectal varices 17.16 10.76 5 93802 66 110495426
Illness 17.11 10.76 27 93780 82144 110413348
Disseminated cytomegaloviral infection 16.98 10.76 9 93798 619 110494873
Bronchitis 16.93 10.76 72 93735 156960 110338532
Normocytic anaemia 16.91 10.76 24 93783 6443 110489049
Polyomavirus test positive 16.90 10.76 7 93800 274 110495218
Pancreatitis necrotising 16.78 10.76 22 93785 5479 110490013
Neoplasm progression 16.76 10.76 18 93789 64577 110430915
Pulmonary valve stenosis 16.76 10.76 6 93801 157 110495335
Necrotising fasciitis 16.73 10.76 26 93781 7565 110487927
Antisynthetase syndrome 16.71 10.76 7 93800 282 110495210
Neutropenia 16.70 10.76 426 93381 374194 110121298
Cardiac autonomic neuropathy 16.69 10.76 5 93802 73 110495419
Pyrexia 16.66 10.76 926 92881 897339 109598153
Thrombotic thrombocytopenic purpura 16.58 10.76 25 93782 7086 110488406
Meningitis 16.57 10.76 33 93774 11669 110483823
Empyema 16.57 10.76 22 93785 5548 110489944
Propionibacterium infection 16.55 10.76 7 93800 289 110495203
Adverse drug reaction 16.53 10.76 41 93766 105518 110389974
Ejection fraction decreased 16.48 10.76 7 93800 40873 110454619
Malignant melanoma 16.44 10.76 41 93766 16850 110478642
Vascular hyalinosis 16.41 10.76 6 93801 167 110495325
Retroperitoneal haematoma 16.40 10.76 23 93784 6108 110489384
Mucinous adenocarcinoma of appendix 16.39 10.76 4 93803 25 110495467
Anti-GAD antibody positive 16.39 10.76 5 93802 78 110495414
Clonal haematopoiesis 16.31 10.76 6 93801 170 110495322
C-reactive protein 16.28 10.76 3 93804 30328 110465164
Dry eye 16.28 10.76 14 93793 55779 110439713
Sebaceous carcinoma 16.25 10.76 6 93801 172 110495320
Acid base balance abnormal 16.22 10.76 8 93799 473 110495019
Anaphylactic shock 16.21 10.76 12 93795 51534 110443958
Kaposi sarcoma inflammatory cytokine syndrome 16.21 10.76 6 93801 173 110495319
Dyskinesia 16.15 10.76 12 93795 51434 110444058
Extravasation of urine 16.14 10.76 3 93804 3 110495489
Candida sepsis 16.14 10.76 16 93791 2945 110492547
Cervical spinal cord paralysis 16.13 10.76 4 93803 27 110495465
Anastomotic stenosis 16.11 10.76 9 93798 687 110494805
Chronic inflammatory demyelinating polyradiculoneuropathy 16.11 10.76 14 93793 2181 110493311
Cutaneous blastomycosis 16.10 10.76 5 93802 83 110495409
Renal tuberculosis 16.10 10.76 5 93802 83 110495409
Viral haemorrhagic cystitis 16.05 10.76 17 93790 3382 110492110
Hyperamylasaemia 16.03 10.76 11 93796 1210 110494282
Stevens-Johnson syndrome 15.98 10.76 10 93797 46891 110448601
Bone pain 15.98 10.76 19 93788 65114 110430378
Locked-in syndrome 15.97 10.76 10 93797 942 110494550
Arthritis bacterial 15.91 10.76 31 93776 10789 110484703
Cerebral fungal infection 15.88 10.76 9 93798 706 110494786
Femur fracture 15.83 10.76 9 93798 44460 110451032
Large intestine perforation 15.80 10.76 40 93767 16589 110478903
Disease complication 15.79 10.76 22 93785 5805 110489687
Serratia infection 15.76 10.76 14 93793 2245 110493247
Meningitis Escherichia 15.76 10.76 4 93803 30 110495462
Intentional self-injury 15.76 10.76 6 93801 37423 110458069
Treatment noncompliance 15.73 10.76 111 93696 72879 110422613
Necrotising herpetic retinopathy 15.71 10.76 6 93801 189 110495303
Cutaneous mucormycosis 15.71 10.76 9 93798 721 110494771
Abdominal wall abscess 15.70 10.76 12 93795 1560 110493932
Hemianopia heteronymous 15.62 10.76 5 93802 92 110495400
Bacterial endophthalmitis 15.57 10.76 7 93800 335 110495157
Renal cortical necrosis 15.57 10.76 8 93799 516 110494976
Granulomatous dermatitis 15.54 10.76 8 93799 518 110494974
Creatinine urine increased 15.54 10.76 8 93799 518 110494974
Enterococcal bacteraemia 15.45 10.76 19 93788 4442 110491050
Herpes zoster cutaneous disseminated 15.44 10.76 8 93799 525 110494967
Paracoccidioides infection 15.42 10.76 5 93802 96 110495396
Trichosporon infection 15.41 10.76 11 93796 1289 110494203
Thyroid gland abscess 15.32 10.76 5 93802 98 110495394
Incisional hernia 15.26 10.76 15 93792 2732 110492760
Vesicoureteric reflux 15.25 10.76 6 93801 205 110495287
Urinary tract infection viral 15.23 10.76 5 93802 100 110495392
Lymphorrhoea 15.23 10.76 6 93801 206 110495286
Functional gastrointestinal disorder 15.16 10.76 22 93785 6027 110489465
Agranulocytosis 15.15 10.76 97 93710 61663 110433829
Sopor 15.15 10.76 6 93801 36540 110458952
Pneumomediastinum 15.15 10.76 20 93787 5016 110490476
Nightmare 15.12 10.76 7 93800 38856 110456636
Haemoglobinaemia 15.12 10.76 7 93800 359 110495133
Orbital apex syndrome 15.09 10.76 5 93802 103 110495389
Blindness 15.06 10.76 66 93741 36293 110459199
Brain herniation 15.04 10.76 27 93780 8836 110486656
Basal cell carcinoma 14.98 10.76 77 93730 45193 110450299
Gastrointestinal mucosa hyperaemia 14.96 10.76 8 93799 560 110494932
Influenza like illness 14.91 10.76 33 93774 88379 110407113
Onychomycosis 14.90 10.76 7 93800 38524 110456968
Human herpesvirus 6 encephalitis 14.87 10.76 10 93797 1064 110494428
Heart rate increased 14.86 10.76 67 93740 143767 110351725
Cardiac murmur functional 14.83 10.76 4 93803 39 110495453
Endocarditis staphylococcal 14.82 10.76 10 93797 1070 110494422
Wound complication 14.81 10.76 22 93785 6155 110489337
Hidradenitis 14.71 10.76 20 93787 5160 110490332
Lymph node tuberculosis 14.62 10.76 10 93797 1094 110494398
Drug withdrawal syndrome 14.58 10.76 7 93800 38047 110457445
Bronchial anastomosis complication 14.57 10.76 5 93802 115 110495377
Stenotrophomonas sepsis 14.55 10.76 6 93801 232 110495260
Blood albumin decreased 14.49 10.76 54 93753 27598 110467894
Dialysis 14.47 10.76 43 93764 19576 110475916
Infective scleritis 14.45 10.76 5 93802 118 110495374
Renal vein thrombosis 14.45 10.76 10 93797 1115 110494377
Injection site haemorrhage 14.40 10.76 5 93802 33023 110462469
Joint injury 14.37 10.76 8 93799 39986 110455506
Swelling face 14.34 10.76 36 93771 92285 110403207
Endocarditis viral 14.33 10.76 3 93804 8 110495484
Duodenitis 14.33 10.76 27 93780 9169 110486323
Central nervous system fungal infection 14.29 10.76 8 93799 613 110494879
Type 2 lepra reaction 14.28 10.76 7 93800 408 110495084
Gastroenteritis 14.26 10.76 68 93739 38732 110456760
Severe acute respiratory syndrome 14.25 10.76 6 93801 245 110495247
Renal disorder 14.24 10.76 81 93726 49398 110446094
Hepatocellular carcinoma 14.16 10.76 28 93779 9852 110485640
Pseudomonal bacteraemia 14.15 10.76 18 93789 4353 110491139
Urine output decreased 14.12 10.76 43 93764 19833 110475659
Gout 14.11 10.76 65 93742 36501 110458991
Blood urine present 14.11 10.76 49 93758 24196 110471296
Conjunctival neoplasm 14.07 10.76 3 93804 9 110495483
Myocarditis infectious 14.00 10.76 5 93802 130 110495362
Irritability 13.95 10.76 12 93795 47797 110447695
Retinitis 13.92 10.76 5 93802 32322 110463170
Ocular hyperaemia 13.91 10.76 8 93799 39278 110456214
Drug eruption 13.87 10.76 15 93792 53644 110441848
Skin lesion 13.87 10.76 83 93724 51548 110443944
Hyperuricaemia 13.86 10.76 35 93772 14496 110480996
Encephalitis protozoal 13.85 10.76 4 93803 51 110495441
Cutaneous B-cell lymphoma 13.82 10.76 5 93802 135 110495357
Device issue 13.78 10.76 6 93801 34529 110460963
Myeloma cast nephropathy 13.76 10.76 6 93801 267 110495225
Adverse reaction 13.76 10.76 4 93803 29590 110465902
Venous stenosis 13.72 10.76 6 93801 269 110495223
Dysarthria 13.70 10.76 32 93775 84089 110411403
Lung abscess 13.70 10.76 19 93788 4993 110490499
Gastrointestinal injury 13.69 10.76 12 93795 1891 110493601
Granulomatous lymphadenitis 13.64 10.76 7 93800 450 110495042
Thrombocytopenia 13.62 10.76 390 93417 348495 110146997
Biliary obstruction 13.62 10.76 20 93787 5538 110489954
Gastroenteritis listeria 13.61 10.76 3 93804 11 110495481
Lymphoproliferative disorder 13.57 10.76 23 93784 7195 110488297
Campylobacter gastroenteritis 13.55 10.76 12 93795 1917 110493575
Cytomegalovirus gastritis 13.53 10.76 8 93799 680 110494812
Subdural haematoma 13.53 10.76 7 93800 36447 110459045
Nephritis 13.53 10.76 21 93786 6105 110489387
Antibody test negative 13.51 10.76 4 93803 56 110495436
Pancreas transplant 13.51 10.76 4 93803 56 110495436
Gastrinoma 13.51 10.76 4 93803 56 110495436
Diarrhoea infectious 13.49 10.76 12 93795 1928 110493564
Streptococcal endocarditis 13.45 10.76 6 93801 282 110495210
Blood creatine phosphokinase increased 13.41 10.76 26 93781 73051 110422441
Fusarium infection 13.33 10.76 14 93793 2757 110492735
Hepatitis 13.31 10.76 36 93771 90018 110405474
Cutaneous tuberculosis 13.27 10.76 6 93801 291 110495201
Acute hepatitis C 13.26 10.76 6 93801 292 110495200
Extrapyramidal disorder 13.24 10.76 4 93803 28863 110466629
Urine protein/creatinine ratio decreased 13.21 10.76 3 93804 13 110495479
Wound infection 13.21 10.76 40 93767 96425 110399067
Paraesthesia oral 13.20 10.76 6 93801 33665 110461827
Pleural effusion 13.19 10.76 218 93589 177491 110318001
Muscle spasticity 13.17 10.76 7 93800 35908 110459584
Post procedural urine leak 13.17 10.76 5 93802 155 110495337
Cryptococcal fungaemia 13.12 10.76 6 93801 299 110495193
Central nervous system vasculitis 13.06 10.76 11 93796 1643 110493849
Pancreatic pseudocyst 13.03 10.76 11 93796 1647 110493845
Neurological decompensation 13.02 10.76 22 93785 6861 110488631
Complement factor decreased 13.02 10.76 5 93802 160 110495332
Blood test abnormal 13.02 10.76 4 93803 28550 110466942
Bone tuberculosis 13.01 10.76 8 93799 730 110494762
CD8 lymphocytes decreased 12.97 10.76 6 93801 307 110495185
Orf 12.90 10.76 4 93803 66 110495426
Terminal ileitis 12.88 10.76 11 93796 1673 110493819
Tremor 12.84 10.76 242 93565 201990 110293502
Renal arteriosclerosis 12.74 10.76 7 93800 517 110494975
Oral pain 12.73 10.76 8 93799 37436 110458056
Cytopenia 12.73 10.76 55 93752 30061 110465431
Epistaxis 12.72 10.76 62 93745 130310 110365182
Coxsackie virus test positive 12.70 10.76 3 93804 16 110495476
Sebaceous gland disorder 12.68 10.76 4 93803 70 110495422
Gastroenteritis salmonella 12.65 10.76 10 93797 1365 110494127
Narrow anterior chamber angle 12.65 10.76 5 93802 173 110495319
Central nervous system infection 12.62 10.76 11 93796 1721 110493771
Blood immunoglobulin G decreased 12.61 10.76 19 93788 5381 110490111
Renal haemorrhage 12.59 10.76 13 93794 2512 110492980
Sinus disorder 12.57 10.76 6 93801 32722 110462770
Bartonella test positive 12.54 10.76 3 93804 17 110495475
Scopulariopsis infection 12.52 10.76 5 93802 178 110495314
Hepatic infection fungal 12.52 10.76 6 93801 333 110495159
Gene mutation 12.52 10.76 15 93792 3414 110492078
Coordination abnormal 12.51 10.76 3 93804 25225 110470267
Abdominal wound dehiscence 12.50 10.76 6 93801 334 110495158
Genital herpes 12.49 10.76 13 93794 2534 110492958
Nephrostomy 12.47 10.76 6 93801 336 110495156
Choriomeningitis lymphocytic 12.44 10.76 5 93802 181 110495311
Arteritis infective 12.44 10.76 5 93802 181 110495311
Arteriovenous fistula occlusion 12.44 10.76 7 93800 542 110494950
Acinetobacter bacteraemia 12.40 10.76 6 93801 340 110495152
Photodermatosis 12.40 10.76 9 93798 1082 110494410
Intestinal ulcer perforation 12.40 10.76 3 93804 18 110495474
Neuropathy peripheral 12.39 10.76 95 93712 179182 110316310
Abnormal behaviour 12.39 10.76 9 93798 39030 110456462
Acute oesophageal mucosal lesion 12.39 10.76 5 93802 183 110495309
Hyperglycaemic hyperosmolar nonketotic syndrome 12.38 10.76 14 93793 2995 110492497
Central nervous system lesion 12.34 10.76 35 93772 15518 110479974
Conjunctival scar 12.30 10.76 6 93801 346 110495146
Blood pressure ambulatory increased 12.28 10.76 4 93803 78 110495414
Muscle necrosis 12.27 10.76 11 93796 1786 110493706
Enterocolitis haemorrhagic 12.25 10.76 13 93794 2591 110492901
Large intestine infection 12.24 10.76 17 93790 4475 110491017
Endocarditis bacterial 12.22 10.76 11 93796 1794 110493698
Delirium 12.17 10.76 66 93741 134959 110360533
Peliosis hepatis 12.16 10.76 5 93802 192 110495300
Full blood count decreased 12.16 10.76 6 93801 32093 110463399
Neuralgia 12.04 10.76 14 93793 48464 110447028
Pulmonary tuberculosis 12.03 10.76 25 93782 9114 110486378
Metastases to spleen 12.03 10.76 8 93799 836 110494656
Systemic inflammatory response syndrome 12.01 10.76 31 93776 13012 110482480
Diverticulum intestinal 11.99 10.76 29 93778 11690 110483802
Ureteric obstruction 11.99 10.76 14 93793 3100 110492392
Red blood cell sedimentation rate abnormal 11.98 10.76 3 93804 24506 110470986
Soft tissue infection 11.97 10.76 18 93789 5089 110490403
Cardio-respiratory arrest 11.94 10.76 54 93753 115782 110379710
Eye ulcer 11.94 10.76 6 93801 369 110495123
Endocarditis enterococcal 11.91 10.76 6 93801 371 110495121
Device dislocation 11.90 10.76 6 93801 31698 110463794
Lung consolidation 11.89 10.76 27 93780 10449 110485043
Tularaemia 11.88 10.76 5 93802 204 110495288
Cutaneous sporotrichosis 11.83 10.76 4 93803 88 110495404
Metastases to salivary gland 11.74 10.76 4 93803 90 110495402
Ocular lymphoma 11.69 10.76 5 93802 212 110495280
Hepatic cyst infection 11.67 10.76 5 93802 213 110495279
Encapsulating peritoneal sclerosis 11.66 10.76 8 93799 880 110494612
Renal ischaemia 11.65 10.76 12 93795 2311 110493181
Scleroderma 11.65 10.76 20 93787 6321 110489171
Renal tubular dysfunction 11.64 10.76 8 93799 882 110494610
Osteomyelitis acute 11.59 10.76 7 93800 618 110494874
Panic attack 11.59 10.76 5 93802 28935 110466557
Adenocarcinoma metastatic 11.58 10.76 6 93801 394 110495098
Protein urine 11.57 10.76 10 93797 1546 110493946
Microvascular coronary artery disease 11.52 10.76 6 93801 398 110495094
Hepatitis infectious mononucleosis 11.50 10.76 5 93802 221 110495271
Dysphonia 11.49 10.76 30 93777 75899 110419593
Disturbance in attention 11.42 10.76 22 93785 61973 110433519
Osteomalacia 11.40 10.76 10 93797 1577 110493915
Disseminated trichosporonosis 11.39 10.76 5 93802 226 110495266
Postoperative ileus 11.37 10.76 9 93798 1231 110494261
Viral sepsis 11.37 10.76 5 93802 227 110495265
Aortic valve thickening 11.35 10.76 5 93802 228 110495264
Sepsis syndrome 11.35 10.76 10 93797 1586 110493906
Respiratory tract congestion 11.34 10.76 6 93801 30851 110464641
Meningitis streptococcal 11.33 10.76 5 93802 229 110495263
Herpes oesophagitis 11.31 10.76 6 93801 413 110495079
Viral vasculitis 11.31 10.76 5 93802 230 110495262
Pneumonia influenzal 11.27 10.76 15 93792 3790 110491702
Lung disorder 11.26 10.76 98 93709 179949 110315543
Toxic leukoencephalopathy 11.24 10.76 10 93797 1607 110493885
Splenorenal shunt 11.24 10.76 3 93804 28 110495464
Heart transplant 11.18 10.76 10 93797 1618 110493874
Metastases to lymph nodes 11.13 10.76 33 93774 14999 110480493
Coronary artery disease 11.10 10.76 28 93779 71662 110423830
Arteriosclerosis 11.06 10.76 46 93761 24721 110470771
Bone marrow granuloma 11.05 10.76 3 93804 30 110495462
Pupillary deformity 11.05 10.76 3 93804 30 110495462
Gastroenteritis adenovirus 11.05 10.76 6 93801 433 110495059
Oedematous pancreatitis 11.04 10.76 10 93797 1644 110493848
Bacterial colitis 11.03 10.76 5 93802 244 110495248
B-lymphocyte count decreased 11.01 10.76 11 93796 2044 110493448
Gastrointestinal necrosis 10.98 10.76 20 93787 6620 110488872
Typhoid fever 10.92 10.76 4 93803 112 110495380
Hepatic enzyme abnormal 10.90 10.76 25 93782 9738 110485754
Electrolyte imbalance 10.90 10.76 61 93746 36967 110458525
Supine hypertension 10.90 10.76 6 93801 445 110495047
Breast cancer 10.85 10.76 10 93797 38532 110456960
Blood pressure increased 10.85 10.76 154 93653 258219 110237273
Toxic optic neuropathy 10.83 10.76 9 93798 1319 110494173
Breath sounds abnormal 10.81 10.76 4 93803 25400 110470092
Systemic infection 10.81 10.76 25 93782 9794 110485698
Graft versus host disease in eye 10.79 10.76 6 93801 454 110495038
Infective keratitis 10.79 10.76 4 93803 116 110495376
Gastrointestinal toxicity 10.79 10.76 27 93780 11121 110484371

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AA06 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Selective immunosuppressants
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000903 Antibiotics, Antineoplastic
MeSH PA D000904 Antibiotics, Antitubercular
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000995 Antitubercular Agents
MeSH PA D004791 Enzyme Inhibitors
FDA EPC N0000175613 Antimetabolite Immunosuppressant
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:53746 EC 1.1.1.205 (IMP dehydrogenase) inhibitor
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:231911 renoprotective agent
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:25442 mycotoxin
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:76964 <em>Penicillium</em> metabolite
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:149553 anticoronaviral agent
CHEBI has role CHEBI:233423 antifibrotic agent

Related Drugs by ATC class:

L04AA Selective immunosuppressants 10 drugs
abataceptalefaceptapremilastbelataceptbelumosudilcladribinegusperimusimlifidasenerandomilastremibrutinib

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Prevention of Liver Transplant Rejection indication
Prevention of Cardiac Transplant Rejection indication
Prevention of Kidney Transplant Rejection indication
Prevention of Lung Transplant Rejection off-label use
Herpes zoster contraindication 4740000 DOID:8536
Progressive multifocal leukoencephalopathy contraindication 22255007 DOID:643
Cytomegalovirus infection contraindication 28944009
Constitutional aplastic anemia contraindication 28975000 DOID:1342
Gastrointestinal ulcer contraindication 40845000
Gastrointestinal perforation contraindication 51875005
Acute nephropathy contraindication 58574008
Acute infectious disease contraindication 63171007
Gastrointestinal hemorrhage contraindication 74474003
Herpes simplex contraindication 88594005 DOID:8566
Malignant lymphoma contraindication 118600007 DOID:0060058
Deficiency of hypoxanthine phosphoribosyltransferase contraindication 124275001
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Primary malignant neoplasm contraindication 372087000
Malignant neoplasm of skin contraindication 372130007 DOID:4159
Breastfeeding (mother) contraindication 413712001
Opportunistic Fungal Infection contraindication
BK Polyomavirus Reactivation Nephropathy contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.67 acidic
pKa2 11.03 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Inosine-5'-monophosphate dehydrogenase (IMPDH) Enzyme INHIBITOR IC50 4.70 CHEMBL CHEMBL
Inosine-5'-monophosphate dehydrogenase 1 Enzyme Ki 7.48 CHEMBL
Inosine-5'-monophosphate dehydrogenase 2 Enzyme Ki 8.22 CHEMBL
Inosine-5'-monophosphate dehydrogenase Enzyme IC50 6.92 CHEMBL

External reference:

IDSource
4025608 VUID
N0000176078 NUI
D05095 KEGG_DRUG
24280-93-1 SECONDARY_CAS_RN
4021418 VANDF
4025598 VANDF
4025608 VANDF
C0026933 UMLSCUI
CHEBI:168396 CHEBI
MOA PDB_CHEM_ID
CHEMBL866 ChEMBL_ID
DB01024 DRUGBANK_ID
CHEMBL2106643 ChEMBL_ID
D009173 MESH_DESCRIPTOR_UI
446541 PUBCHEM_CID
6832 IUPHAR_LIGAND_ID
2950 INN_ID
HU9DX48N0T UNII
265323 RXNORM
18132 MMSL
210716 MMSL
d05217 MMSL
005013 NDDF
009984 NDDF
409330005 SNOMEDCT_US
409331009 SNOMEDCT_US
426216009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Myfortic HUMAN PRESCRIPTION DRUG LABEL 1 0078-0385 TABLET, DELAYED RELEASE 180 mg ORAL NDA 29 sections
Myfortic HUMAN PRESCRIPTION DRUG LABEL 1 0078-0386 TABLET, DELAYED RELEASE 360 mg ORAL NDA 29 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0904-6785 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0904-6786 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 23 sections
MYCOPHENOLIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0904-7372 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 28 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 16729-189 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 27 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 16729-261 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 27 sections
mycophenolic acid HUMAN PRESCRIPTION DRUG LABEL 1 24979-160 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 28 sections
mycophenolic acid HUMAN PRESCRIPTION DRUG LABEL 1 24979-161 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 28 sections
MYCOPHENOLIC ACID Human Prescription Drug Label 1 50090-6492 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 28 sections
MYCOPHENOLIC ACID Human Prescription Drug Label 1 59651-621 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 26 sections
MYCOPHENOLIC ACID Human Prescription Drug Label 1 59651-622 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 26 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 60429-016 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 60429-017 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 60505-2965 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 60505-2966 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 23 sections
MYCOPHENOLIC ACID Human Prescription Drug Label 1 67877-426 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 28 sections
MYCOPHENOLIC ACID Human Prescription Drug Label 1 67877-427 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 28 sections
MYCOPHENOLIC ACID Human Prescription Drug Label 1 67877-928 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 28 sections
MYCOPHENOLIC ACID Human Prescription Drug Label 1 67877-929 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 28 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 68084-907 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 25 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 68084-918 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 25 sections
mycophenolic acid HUMAN PRESCRIPTION DRUG LABEL 1 68254-5001 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 26 sections
mycophenolic acid HUMAN PRESCRIPTION DRUG LABEL 1 68254-5002 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 26 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 70377-039 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 27 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 70377-040 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 27 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 70377-126 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 24 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 70377-127 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 24 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 70436-172 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 29 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 70436-173 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 29 sections