metoclopramide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sulpiride derivatives and analogues 1782 364-62-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • metoclopramide
  • metoclopramide hydrochloride
  • metochlopramide
  • methochlopramide
  • metoclopramide hydrochloride hydrate
  • metoclopramide monohydrochloride
  • metoclopramide HCl
  • AHR-3070-C
  • metaclopramide
A dopamine D2 antagonist that is used as an antiemetic.
  • Molecular weight: 299.80
  • Formula: C14H22ClN3O2
  • CLOGP: 2.34
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 67.59
  • ALOGS: -2.99
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg O
30 mg P
30 mg R

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 33.36 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Hosey CM, Chan R, Benet LZ
S (Water solubility) 67 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 20 % Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 76 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 5.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.60 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 7, 1979 FDA BAXTER HLTHCARE CORP

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 511.33 10.00 821 111502 117628 63259071
Drug ineffective 487.51 10.00 687 111636 1044078 62332621
Vomiting 403.07 10.00 2003 110320 557614 62819085
Joint swelling 336.48 10.00 83 112240 327583 63049116
Rheumatoid arthritis 294.44 10.00 48 112275 253771 63122928
Contraindicated product administered 289.55 10.00 26 112297 217622 63159077
Arthropathy 284.76 10.00 39 112284 234753 63141946
Synovitis 269.74 10.00 15 112308 186903 63189796
Drug intolerance 260.67 10.00 110 112213 308551 63068148
Hand deformity 257.29 10.00 5 112318 159452 63217247
Therapeutic product effect decreased 257.17 10.00 23 112300 193164 63183535
Hypokalaemia 240.85 10.00 553 111770 103251 63273448
Nausea 236.52 10.00 2425 109898 852046 62524653
Systemic lupus erythematosus 232.44 10.00 44 112279 208874 63167825
Glossodynia 230.94 10.00 24 112299 178852 63197847
Swelling 203.91 10.00 117 112206 275261 63101438
Neutropenic sepsis 197.69 10.00 191 112132 16247 63360452
Abdominal discomfort 194.64 10.00 169 112154 320716 63055983
Arthralgia 192.41 10.00 455 111868 569255 62807444
Pericarditis 171.51 10.00 17 112306 131562 63245137
Dystonia 166.99 10.00 161 112162 13658 63363041
Wound 160.44 10.00 45 112278 163218 63213481
Mucosal inflammation 157.19 10.00 291 112032 46637 63330062
Dehydration 148.48 10.00 654 111669 172700 63203999
Weight increased 147.84 10.00 146 112177 260646 63116053
Pyrexia 145.83 10.00 1369 110954 469109 62907590
Neutropenia 142.20 10.00 650 111673 174355 63202344
Abdominal pain 137.99 10.00 940 111383 292516 63084183
Sinusitis 136.57 10.00 120 112203 226533 63150166
Hyponatraemia 136.41 10.00 472 111851 111428 63265271
Serotonin syndrome 136.29 10.00 208 112115 28474 63348225
Hypomagnesaemia 135.99 10.00 208 112115 28529 63348170
Treatment failure 132.97 10.00 95 112228 198948 63177751
Discomfort 132.79 10.00 65 112258 167309 63209390
Duodenal ulcer perforation 132.24 10.00 5 112318 87204 63289495
Extrapyramidal disorder 131.62 10.00 139 112184 13145 63363554
Pain 123.85 10.00 786 111537 739842 62636857
Constipation 121.27 10.00 746 111577 224197 63152502
Nasopharyngitis 120.72 10.00 164 112159 254093 63122606
Tardive dyskinesia 119.98 10.00 108 112215 8394 63368305
Torsade de pointes 117.09 10.00 131 112192 13220 63363479
Thrombocytopenia 115.83 10.00 552 111771 150605 63226094
Peripheral swelling 115.06 10.00 183 112140 265759 63110940
Product use issue 114.31 10.00 133 112190 220387 63156312
Hepatic enzyme increased 113.78 10.00 114 112209 202214 63174485
Atelectasis 112.40 10.00 163 112160 21320 63355379
Musculoskeletal stiffness 112.09 10.00 97 112226 184521 63192178
Decreased appetite 111.95 10.00 794 111529 250258 63126441
Psoriatic arthropathy 111.33 10.00 15 112308 91505 63285194
Helicobacter infection 111.00 10.00 16 112307 92769 63283930
Diarrhoea 108.54 10.00 1821 110502 713545 62663154
Anaemia 106.82 10.00 885 111438 292545 63084154
Impaired gastric emptying 102.16 10.00 108 112215 10224 63366475
Muscle injury 101.71 10.00 3 112320 65342 63311357
Electrocardiogram QT prolonged 101.20 10.00 282 112041 59248 63317451
Injection site pain 100.55 10.00 52 112271 129748 63246951
General physical health deterioration 100.49 10.00 655 111668 200747 63175952
Acute kidney injury 98.82 10.00 800 111523 262615 63114084
Computerised tomogram thorax abnormal 97.44 10.00 52 112271 1711 63374988
Product dose omission issue 96.90 10.00 166 112157 234147 63142552
Sepsis 94.22 10.00 526 111797 152597 63224102
Toxic epidermal necrolysis 91.04 10.00 162 112161 25172 63351527
Alopecia 90.34 10.00 301 112022 337235 63039464
Malignant neoplasm progression 90.31 10.00 335 111988 81786 63294913
Pulmonary embolism 86.38 10.00 422 111901 116262 63260437
Impaired healing 81.03 10.00 40 112283 102502 63274197
Neutrophil count decreased 80.41 10.00 251 112072 56155 63320544
Folliculitis 79.88 10.00 14 112309 70303 63306396
Computerised tomogram thorax 76.13 10.00 29 112294 420 63376279
Phaeochromocytoma crisis 76.02 10.00 25 112298 228 63376471
Electrolyte imbalance 74.23 10.00 130 112193 19946 63356753
Completed suicide 73.16 10.00 90 112233 145583 63231116
Parkinsonism 72.62 10.00 91 112232 10348 63366351
Aplastic anaemia 72.36 10.00 87 112236 9482 63367217
Colitis 70.14 10.00 217 112106 48311 63328388
Irritable bowel syndrome 70.03 10.00 29 112294 82383 63294316
Neovascularisation 69.63 10.00 36 112287 1109 63375590
Oculogyric crisis 68.66 10.00 41 112282 1680 63375019
Cytokine release syndrome 66.86 10.00 103 112220 14211 63362488
Arthritis 66.64 10.00 64 112259 115857 63260842
Hypoxia 65.80 10.00 244 112079 59548 63317151
Gastritis 65.66 10.00 179 112144 37124 63339575
Hip arthroplasty 65.20 10.00 5 112318 47641 63329058
Cholecystitis chronic 63.75 10.00 85 112238 10276 63366423
Knee arthroplasty 63.33 10.00 10 112313 54196 63322503
Psoriasis 62.77 10.00 38 112285 86919 63289780
Blood cholesterol increased 61.29 10.00 46 112277 93986 63282713
Cardiac arrest 60.30 10.00 323 112000 92222 63284477
Ejection fraction decreased 59.67 10.00 126 112197 22206 63354493
Contusion 59.54 10.00 109 112214 149935 63226764
Hypersensitivity 59.34 10.00 291 112032 292394 63084305
Condition aggravated 58.01 10.00 445 111878 401772 62974927
Therapeutic product effect incomplete 57.94 10.00 82 112241 124974 63251725
Ileus 57.92 10.00 98 112225 14627 63362072
Pancytopenia 56.95 10.00 329 111994 96604 63280095
Neuropathy peripheral 56.82 10.00 370 111953 113297 63263402
Infusion related reaction 56.43 10.00 233 112090 245288 63131411
Restlessness 55.54 10.00 145 112178 29308 63347391
C-reactive protein abnormal 55.00 10.00 8 112315 46088 63330611
Adverse drug reaction 54.57 10.00 37 112286 79677 63297022
Stevens-Johnson syndrome 53.52 10.00 129 112194 24821 63351878
Phaeochromocytoma 52 10.00 23 112300 496 63376203
Tachycardia 50.99 10.00 371 111952 117785 63258914
Renal ischaemia 50.68 10.00 24 112299 609 63376090
Left ventricular dysfunction 50.11 10.00 82 112241 11906 63364793
Leukopenia 49.83 10.00 269 112054 77021 63299678
Septic shock 48.58 10.00 240 112083 66389 63310310
Mobility decreased 48.08 10.00 88 112235 121071 63255628
Cholestasis 47.63 10.00 137 112186 29297 63347402
Dyskinesia 47.08 10.00 144 112179 31858 63344841
Adverse event 46.72 10.00 31 112292 67528 63309171
Osteoarthritis 46.71 10.00 60 112263 95283 63281416
Peripheral circulatory failure 46.44 10.00 26 112297 942 63375757
Pleural effusion 46.33 10.00 303 112020 92907 63283792
Dysphagia 45.89 10.00 291 112032 88294 63288405
Akathisia 45.82 10.00 68 112255 9078 63367621
Rash maculo-papular 45.51 10.00 142 112181 31754 63344945
Mouth ulceration 45.37 10.00 145 112178 32839 63343860
Red blood cell sedimentation rate increased 45.31 10.00 11 112312 43971 63332728
Intentional product use issue 44.68 10.00 100 112223 127792 63248907
Respiratory dyskinesia 44.58 10.00 11 112312 29 63376670
Diabetes insipidus 44.44 10.00 37 112286 2588 63374111
Injection site bruising 44.13 10.00 10 112313 41900 63334799
PCO2 increased 42.99 10.00 27 112296 1212 63375487
Hepatocellular injury 42.92 10.00 126 112197 27255 63349444
Emotional distress 42.88 10.00 141 112182 32408 63344291
Cholecystitis 42.53 10.00 88 112235 15289 63361410
Fibromyalgia 42.16 10.00 48 112275 80372 63296327
Subileus 42.15 10.00 39 112284 3140 63373559
Duodenal stenosis 41.72 10.00 20 112303 522 63376177
Rash 41.67 10.00 720 111603 560151 62816548
Therapeutic response decreased 41.52 10.00 29 112294 61496 63315203
Ventricular fibrillation 41.50 10.00 75 112248 11792 63364907
PO2 increased 40.52 10.00 23 112300 856 63375843
Skin candida 40.43 10.00 29 112294 1626 63375073
Device expulsion 39.55 10.00 7 112316 34915 63341784
Encephalopathy 39.51 10.00 154 112169 38466 63338233
Blood bicarbonate decreased 38.84 10.00 36 112287 2905 63373794
Disease progression 38.70 10.00 359 111964 122399 63254300
Polydipsia 38.38 10.00 39 112284 3525 63373174
Injection site erythema 38.06 10.00 55 112268 83119 63293580
Transfusion 37.39 10.00 83 112240 15134 63361565
Ascites 37.36 10.00 157 112166 40571 63336128
Excessive eye blinking 37.30 10.00 25 112298 1255 63375444
Blood pressure increased 37.08 10.00 154 112169 161908 63214791
Blood magnesium decreased 37.05 10.00 76 112247 13122 63363577
Ill-defined disorder 36.50 10.00 55 112268 81700 63294999
Small intestinal obstruction 36.35 10.00 92 112231 18245 63358454
Hypocalcaemia 36.21 10.00 131 112192 31582 63345117
Peritonitis 36.05 10.00 88 112235 17066 63359633
Aplasia 36.00 10.00 41 112282 4218 63372481
Malnutrition 35.97 10.00 82 112241 15216 63361483
Injection site swelling 35.44 10.00 20 112303 47552 63329147
Hypotension 35.39 10.00 678 111645 271926 63104773
Injection site reaction 35.18 10.00 31 112292 58493 63318206
Haematemesis 34.20 10.00 125 112198 30287 63346412
Urticaria 34.05 10.00 164 112159 165638 63211061
Wrong technique in product usage process 34.01 10.00 36 112287 62304 63314395
Alveolitis 33.41 10.00 33 112290 2882 63373817
Antinuclear antibody negative 32.22 10.00 13 112310 221 63376478
Gastroenteritis 32.22 10.00 112 112211 26478 63350221
Injection site pruritus 32.15 10.00 20 112303 45096 63331603
Febrile bone marrow aplasia 31.84 10.00 51 112272 7274 63369425
Paradoxical drug reaction 31.80 10.00 38 112285 4114 63372585
Pneumonitis 31.71 10.00 135 112188 35087 63341612
Hepatic failure 30.82 10.00 135 112188 35521 63341178
Hyperprolactinaemia 30.38 10.00 36 112287 3864 63372835
Infection 30.02 10.00 260 112063 228913 63147786
Drug interaction 29.77 10.00 570 111753 228561 63148138
Dyspnoea 29.76 10.00 1442 110881 659871 62716828
Blood pressure fluctuation 29.74 10.00 23 112300 46294 63330405
Abortion spontaneous 29.59 10.00 24 112299 47171 63329528
Urinary retention 29.52 10.00 119 112204 30182 63346517
Coombs positive haemolytic anaemia 29.50 10.00 14 112309 357 63376342
Pancreatitis acute 29.16 10.00 110 112213 27056 63349643
Blood pH decreased 29.12 10.00 29 112294 2558 63374141
Gamma-glutamyltransferase increased 28.77 10.00 128 112195 33903 63342796
Grip strength decreased 28.71 10.00 3 112320 22284 63354415
Oesophagitis 28.41 10.00 74 112249 14934 63361765
Immune effector cell-associated neurotoxicity syndrome 28.40 10.00 27 112296 2250 63374449
Nervous system disorder 28.12 10.00 85 112238 18681 63358018
Premature delivery 27.98 10.00 117 112206 30164 63346535
Accidental exposure to product 27.95 10.00 7 112316 27398 63349301
Nail infection 27.88 10.00 28 112295 2495 63374204
Cataract 27.84 10.00 36 112287 57017 63319682
Hypophosphataemia 27.71 10.00 62 112261 11364 63365335
Erysipelas 27.69 10.00 50 112273 7855 63368844
Neuroleptic malignant syndrome 27.66 10.00 64 112259 11992 63364707
Heart rate decreased 27.54 10.00 24 112299 45536 63331163
Type 2 diabetes mellitus 27.52 10.00 44 112279 63824 63312875
Asthma 27.47 10.00 124 112199 127437 63249262
Loss of personal independence in daily activities 27.18 10.00 85 112238 97205 63279494
Long QT syndrome 26.76 10.00 31 112292 3248 63373451
Seizure 26.69 10.00 355 111968 132279 63244420
Enterocolitis 26.64 10.00 49 112274 7809 63368890
Deep vein thrombosis 26.37 10.00 245 112078 83555 63293144
Respiratory failure 26.36 10.00 286 112037 101572 63275127
Mixed liver injury 26.34 10.00 37 112286 4698 63372001
Hypoaesthesia 26.29 10.00 182 112141 168211 63208488
Secondary adrenocortical insufficiency 26 10.00 21 112302 1407 63375292
Agitation 25.97 10.00 188 112135 59569 63317130
Blister 25.73 10.00 130 112193 129684 63247015
Pain in extremity 25.70 10.00 422 111901 331064 63045635
Multiple organ dysfunction syndrome 25.51 10.00 180 112143 56572 63320127
Myocardial reperfusion injury 25.39 10.00 9 112314 105 63376594
Respiratory syncytial virus infection 25.37 10.00 45 112278 6973 63369726
Infusion site streaking 24.91 10.00 14 112309 511 63376188
Hydronephrosis 24.90 10.00 57 112266 10605 63366094
Sciatica 24.76 10.00 15 112308 34309 63342390
Pancreatitis 24.69 10.00 160 112163 48895 63327804
Gastritis haemorrhagic 24.55 10.00 21 112302 1524 63375175
Prescribed underdose 24.34 10.00 11 112312 29678 63347021
Hyponatraemic seizure 24.30 10.00 13 112310 430 63376269
Urosepsis 24.18 10.00 80 112243 18444 63358255
Radiation pneumonitis 24.11 10.00 21 112302 1562 63375137
Onychalgia 23.69 10.00 17 112306 954 63375745
Pituitary tumour benign 23.64 10.00 23 112300 1972 63374727
Inflammation 23.61 10.00 71 112252 82202 63294497
Hypochloraemia 23.51 10.00 23 112300 1986 63374713
Blood creatinine increased 23.35 10.00 248 112075 87596 63289103
Oropharyngeal spasm 23.30 10.00 11 112312 277 63376422
Gelastic seizure 23.24 10.00 5 112318 5 63376694
Anxiety disorder 23.06 10.00 32 112291 4018 63372681
Duodenal perforation 23.05 10.00 16 112307 851 63375848
Therapy non-responder 22.88 10.00 64 112259 75837 63300862
Clonus 22.55 10.00 34 112289 4602 63372097
Inappropriate schedule of product administration 22.42 10.00 101 112222 103864 63272835
Sleep disorder 22.27 10.00 72 112251 81494 63295205
Gynaecomastia 22.26 10.00 10 112313 224 63376475
Carcinoid tumour of the stomach 22.04 10.00 9 112314 158 63376541
COVID-19 21.99 10.00 114 112209 112989 63263710
Enterochromaffin cell hyperplasia 21.98 10.00 7 112316 57 63376642
Cholelithiasis 21.94 10.00 143 112180 43782 63332917
Disturbance in social behaviour 21.91 10.00 31 112292 3962 63372737
Sinus disorder 21.91 10.00 8 112315 24545 63352154
Hypophagia 21.65 10.00 111 112212 31148 63345551
Intestinal perforation 21.64 10.00 58 112265 11905 63364794
Pneumonia 21.55 10.00 1001 111322 455766 62920933
No adverse event 21.39 10.00 25 112298 41380 63335319
Hypergastrinaemia 21.38 10.00 8 112315 110 63376589
Hyperglycaemia 21.34 10.00 137 112186 41730 63334969
Bone erosion 21.31 10.00 3 112320 17714 63358985
Herpes simplex reactivation 21.29 10.00 13 112310 555 63376144
Joint injury 21.22 10.00 13 112310 29559 63347140
Fatigue 21.16 10.00 1322 111001 886706 62489993
Eructation 21.09 10.00 46 112277 8287 63368412
Brain oedema 20.99 10.00 64 112259 14131 63362568
Intestinal obstruction 20.90 10.00 109 112214 30790 63345909
Malignant polyp 20.88 10.00 9 112314 182 63376517
Aquagenic pruritus 20.86 10.00 6 112317 33 63376666
Apallic syndrome 20.82 10.00 14 112309 707 63375992
Foetal death 20.64 10.00 54 112269 10926 63365773
Electrocardiogram T wave inversion 20.56 10.00 28 112295 3453 63373246
Fall 20.46 10.00 533 111790 391801 62984898
Lethargy 20.34 10.00 169 112154 55838 63320861
Presyncope 20.18 10.00 100 112223 27685 63349014
Nasal congestion 20.06 10.00 55 112268 65605 63311094
Abdominal pain upper 19.89 10.00 492 111831 205952 63170747
Thymus disorder 19.86 10.00 10 112313 291 63376408
Joint range of motion decreased 19.70 10.00 17 112306 32411 63344288
Delusional disorder, persecutory type 19.58 10.00 9 112314 213 63376486
Plantar erythema 19.43 10.00 9 112314 217 63376482
Wheezing 19.36 10.00 95 112228 95500 63281199
Blood alkaline phosphatase increased 19.15 10.00 136 112187 42831 63333868
Dyspepsia 19.11 10.00 270 112053 101926 63274773
Dysuria 18.82 10.00 113 112210 33625 63343074
Oxygen saturation abnormal 18.78 10.00 27 112296 3502 63373197
Acute interstitial pneumonitis 18.74 10.00 13 112310 691 63376008
Generalised tonic-clonic seizure 18.70 10.00 101 112222 28915 63347784
Aortic rupture 18.66 10.00 7 112316 97 63376602
Torticollis 18.61 10.00 20 112303 1929 63374770
Bursitis 18.46 10.00 23 112300 37018 63339681
Herpes zoster 18.45 10.00 79 112244 82383 63294316
Acute abdomen 18.39 10.00 18 112305 1555 63375144
Prescribed overdose 18.32 10.00 20 112303 34133 63342566
Premature baby 18.29 10.00 79 112244 20656 63356043
Blood pressure systolic increased 18.28 10.00 35 112288 47362 63329337
Obstruction gastric 18.23 10.00 15 112308 1032 63375667
Hypoalbuminaemia 18.19 10.00 54 112269 11751 63364948
Memory impairment 18.14 10.00 109 112214 104149 63272550
Multiple drug therapy 18.11 10.00 27 112296 3619 63373080
Neuroglycopenia 18.07 10.00 11 112312 467 63376232
Drug resistance 18.02 10.00 9 112314 22924 63353775
Anuria 18.01 10.00 56 112267 12495 63364204
Neoplasm progression 17.83 10.00 118 112205 36310 63340389
Hyperkalaemia 17.82 10.00 160 112163 54043 63322656
Swollen tongue 17.81 10.00 114 112209 34686 63342013
Pruritus 17.80 10.00 495 111828 360958 63015741
Hypoglycaemic seizure 17.77 10.00 11 112312 481 63376218
Peripheral venous disease 17.75 10.00 3 112320 15474 63361225
Ear infection 17.74 10.00 25 112298 38188 63338511
Foot deformity 17.67 10.00 14 112309 27839 63348860
Liver injury 17.53 10.00 52 112271 60468 63316231
Influenza 17.21 10.00 117 112206 108605 63268094
Injection site haemorrhage 17.02 10.00 11 112312 24303 63352396
Haemorrhoids 17.01 10.00 81 112242 22069 63354630
Systemic infection 17.00 10.00 30 112293 4630 63372069
Road traffic accident 16.98 10.00 24 112299 36608 63340091
Non-small cell lung cancer 16.97 10.00 26 112297 3569 63373130
Joint stiffness 16.97 10.00 30 112293 41839 63334860
Inappropriate antidiuretic hormone secretion 16.92 10.00 63 112260 15399 63361300
Talipes 16.85 10.00 17 112306 1523 63375176
Diabetic gastroparesis 16.84 10.00 9 112314 297 63376402
Vitamin B12 decreased 16.84 10.00 26 112297 3594 63373105
Drug tolerance decreased 16.81 10.00 5 112318 17468 63359231
Renal failure 16.76 10.00 297 112026 117355 63259344
Fluid replacement 16.70 10.00 9 112314 302 63376397
Cystitis noninfective 16.69 10.00 14 112309 989 63375710
Tumour lysis syndrome 16.68 10.00 44 112279 8946 63367753
Illness 16.61 10.00 39 112284 49020 63327679
Gastric polyps 16.60 10.00 25 112298 3380 63373319
Hiccups 16.40 10.00 20 112303 2211 63374488
Cancer pain 16.30 10.00 24 112299 3181 63373518
Joint effusion 16.20 10.00 5 112318 17055 63359644
Biliary dyskinesia 16.19 10.00 22 112301 2707 63373992
Feeling abnormal 16.19 10.00 176 112147 148216 63228483
Gaze palsy 16.14 10.00 16 112307 1404 63375295
Maternal exposure during pregnancy 16.11 10.00 283 112040 219779 63156920
Gallbladder injury 16.11 10.00 16 112307 1407 63375292
Staring 16.05 10.00 17 112306 1613 63375086
Intentional overdose 16.01 10.00 72 112251 74080 63302619
Tumour pain 15.98 10.00 16 112307 1421 63375278
Circulatory collapse 15.97 10.00 79 112244 21859 63354840
Paraesthesia oral 15.95 10.00 72 112251 19184 63357515
Flail chest 15.94 10.00 6 112317 84 63376615
Gastrointestinal stoma complication 15.92 10.00 18 112305 1837 63374862
Immunodeficiency 15.84 10.00 8 112315 20246 63356453
Toxic cardiomyopathy 15.57 10.00 7 112316 157 63376542
Anaphylactic reaction 15.47 10.00 182 112141 65918 63310781
Lung perforation 15.44 10.00 6 112317 92 63376607
Bronchitis 15.36 10.00 144 112179 124791 63251908
Catheter site bruise 15.30 10.00 10 112313 481 63376218
Thoracic operation 15.25 10.00 7 112316 165 63376534
Thirst 15.19 10.00 57 112266 13984 63362715
Bezoar 15.17 10.00 16 112307 1510 63375189
Carpal tunnel syndrome 15.15 10.00 9 112314 20808 63355891
Aspartate aminotransferase increased 15.11 10.00 234 112089 90043 63286656
Granulocytopenia neonatal 14.95 10.00 4 112319 16 63376683
Blood pressure diastolic decreased 14.93 10.00 11 112312 22695 63354004
Gait disturbance 14.91 10.00 231 112092 182947 63193752
Paranoia 14.85 10.00 50 112273 11629 63365070
Pulmonary fibrosis 14.83 10.00 30 112293 39779 63336920
Dermatitis exfoliative 14.81 10.00 31 112292 5428 63371271
Alanine aminotransferase increased 14.80 10.00 262 112061 103508 63273191
Hospitalisation 14.77 10.00 89 112234 84992 63291707
Platelet count decreased 14.76 10.00 288 112035 115834 63260865
Palmar-plantar erythrodysaesthesia syndrome 14.75 10.00 80 112243 22935 63353764
Bradykinesia 14.71 10.00 30 112293 5158 63371541
Drug ineffective for unapproved indication 14.70 10.00 107 112216 33956 63342743
Chronic sinusitis 14.62 10.00 53 112270 12790 63363909
Premature labour 14.57 10.00 52 112271 12452 63364247
Leukocytosis 14.55 10.00 87 112236 25848 63350851
Blood bilirubin increased 14.53 10.00 114 112209 37026 63339673
Bacteraemia 14.47 10.00 65 112258 17283 63359416
Bone density decreased 14.39 10.00 4 112319 14608 63362091
Basal cell carcinoma 14.35 10.00 17 112306 27974 63348725
Vagus nerve disorder 14.31 10.00 6 112317 113 63376586
Rectal haemorrhage 14.26 10.00 141 112182 48889 63327810
Large intestine perforation 14.23 10.00 40 112283 8442 63368257
Escherichia bacteraemia 14.17 10.00 25 112298 3858 63372841
Meconium ileus 13.94 10.00 3 112320 3 63376696
Lip dry 13.87 10.00 5 112318 15465 63361234
Haemangioma of skin 13.86 10.00 9 112314 428 63376271
Rhinovirus infection 13.81 10.00 27 112296 4502 63372197
Amylase increased 13.81 10.00 33 112290 6312 63370387
Cachexia 13.80 10.00 31 112292 5695 63371004
Vascular encephalopathy 13.79 10.00 9 112314 432 63376267
Multiple sclerosis relapse 13.79 10.00 42 112281 48436 63328263
Gastrointestinal submucosal tumour 13.76 10.00 4 112319 23 63376676
Naevus haemorrhage 13.76 10.00 6 112317 125 63376574
Methaemoglobinaemia 13.70 10.00 19 112304 2384 63374315
Coeliac disease 13.58 10.00 3 112320 12794 63363905
Muscle rigidity 13.55 10.00 48 112275 11452 63365247
Neuroendocrine tumour 13.49 10.00 11 112312 747 63375952
Face oedema 13.46 10.00 71 112252 20141 63356558
Lung infiltration 13.45 10.00 56 112267 14407 63362292
Hypoglycaemia 13.44 10.00 164 112159 59901 63316798
Aspiration 13.40 10.00 46 112277 10805 63365894
Product quality issue 13.39 10.00 27 112296 35838 63340861
Sinus tachycardia 13.36 10.00 81 112242 24187 63352512
Economic problem 13.32 10.00 17 112306 1969 63374730
Granulomatous liver disease 13.24 10.00 11 112312 767 63375932
Bronchiectasis 13.20 10.00 6 112317 16136 63360563
Hypercholesterolaemia 13.19 10.00 11 112312 21323 63355376
Product storage error 13.13 10.00 5 112318 14951 63361748
Leukoencephalopathy 13.09 10.00 26 112297 4387 63372312
Antiphospholipid syndrome 13.09 10.00 16 112307 1774 63374925
Drug dependence 13.02 10.00 81 112242 24402 63352297
Immune-mediated hepatitis 12.97 10.00 14 112309 1357 63375342
Blood phosphorus decreased 12.92 10.00 26 112297 4427 63372272
Lower respiratory tract infection 12.85 10.00 161 112162 132146 63244553
Foot fracture 12.83 10.00 14 112309 23900 63352799
Abdominal distension 12.82 10.00 220 112103 86395 63290304
Drug tolerance increased 12.80 10.00 7 112316 242 63376457
Rhinorrhoea 12.80 10.00 66 112257 65511 63311188
Intentional self-injury 12.75 10.00 16 112307 25671 63351028
Throat irritation 12.68 10.00 30 112293 37617 63339082
Adrenal insufficiency 12.67 10.00 64 112259 17851 63358848
Muscle contracture 12.64 10.00 14 112309 1397 63375302
Exostosis 12.61 10.00 8 112315 17854 63358845
Patent ductus arteriosus 12.56 10.00 25 112298 4225 63372474
Parkinson's disease 12.51 10.00 13 112310 1206 63375493
Electrocardiogram change 12.46 10.00 10 112313 664 63376035
Pulmonary air leakage 12.41 10.00 4 112319 34 63376665
Peripheral sensory neuropathy 12.36 10.00 35 112288 7416 63369283
Oromandibular dystonia 12.34 10.00 9 112314 518 63376181
Escherichia test positive 12.34 10.00 18 112305 2366 63374333
Hyperthyroidism 12.26 10.00 55 112268 14618 63362081
Abdominal tenderness 12.25 10.00 37 112286 8129 63368570
Cholangitis 12.19 10.00 29 112294 5532 63371167
Therapy cessation 12.18 10.00 22 112301 30435 63346264
Headache 12.18 10.00 960 111363 632281 62744418
Porphyria 12.13 10.00 6 112317 168 63376531
Lower limb fracture 12.11 10.00 15 112308 24206 63352493
Starvation 12.10 10.00 7 112316 270 63376429
Disseminated intravascular coagulation 12.06 10.00 66 112257 18985 63357714
Drug clearance decreased 12.06 10.00 14 112309 1470 63375229
Stridor 12.04 10.00 22 112301 3488 63373211
Night sweats 12.03 10.00 45 112278 48769 63327930
Urinary tract infection 12.01 10.00 578 111745 264106 63112593
Lung disorder 11.96 10.00 63 112260 62198 63314501
Non-cardiac chest pain 11.95 10.00 31 112292 6241 63370458
Urinary tract obstruction 11.91 10.00 17 112306 2191 63374508
Pregnancy 11.90 10.00 30 112293 36806 63339893
Otospondylomegaepiphyseal dysplasia 11.89 10.00 5 112318 95 63376604
Electrocardiogram QT interval abnormal 11.87 10.00 6 112317 176 63376523
Device dislocation 11.75 10.00 17 112306 25688 63351011
PCO2 decreased 11.71 10.00 13 112310 1300 63375399
Metastatic malignant melanoma 11.70 10.00 13 112310 1302 63375397
Catatonia 11.66 10.00 25 112298 4452 63372247
Metastases to central nervous system 11.61 10.00 50 112273 13055 63363644
Chronic fatigue syndrome 11.61 10.00 12 112311 1106 63375593
Oesophageal ulcer 11.61 10.00 25 112298 4465 63372234
Tooth disorder 11.57 10.00 20 112303 28137 63348562
Febrile infection 11.52 10.00 14 112309 1543 63375156
Gastrointestinal necrosis 11.51 10.00 19 112304 2779 63373920
Myoclonus 11.45 10.00 57 112266 15811 63360888
Lacrimation increased 11.44 10.00 69 112254 20562 63356137
Muscle spasticity 11.43 10.00 13 112310 21781 63354918
Blood cholesterol decreased 11.41 10.00 11 112312 933 63375766
Diabetes mellitus inadequate control 11.39 10.00 55 112268 15071 63361628
Prolactin-producing pituitary tumour 11.30 10.00 5 112318 108 63376591
Device malfunction 11.29 10.00 9 112314 17848 63358851
Restless arm syndrome 11.26 10.00 4 112319 47 63376652
Peptic ulcer 11.25 10.00 25 112298 4562 63372137
Urea urine increased 11.21 10.00 3 112320 12 63376687
Leukostasis syndrome 11.18 10.00 4 112319 48 63376651
Vascular pain 11.14 10.00 10 112313 774 63375925
Upper gastrointestinal haemorrhage 11.07 10.00 64 112259 18788 63357911
Syncope 11.07 10.00 279 112044 117106 63259593
Complex regional pain syndrome 11.06 10.00 17 112306 2340 63374359
Immune-mediated enterocolitis 11.01 10.00 16 112307 2095 63374604
Tachypnoea 11.00 10.00 60 112263 17242 63359457
Reflux gastritis 10.95 10.00 12 112311 1183 63375516
Lip erosion 10.94 10.00 11 112312 982 63375717
Epilepsy congenital 10.84 10.00 3 112320 14 63376685
Tracheal injury 10.82 10.00 4 112319 53 63376646
Insomnia 10.78 10.00 294 112029 214958 63161741
Peritoneal perforation 10.78 10.00 5 112318 121 63376578
Nephritis allergic 10.73 10.00 6 112317 217 63376482
Abdominal mass 10.68 10.00 19 112304 2951 63373748
Anal injury 10.66 10.00 5 112318 124 63376575
Foetal malpresentation 10.63 10.00 5 112318 125 63376574
Device issue 10.61 10.00 16 112307 23765 63352934
Lupus-like syndrome 10.60 10.00 7 112316 15288 63361411
Urinary tract infection enterococcal 10.59 10.00 18 112305 2695 63374004
Subacute combined cord degeneration 10.55 10.00 6 112317 224 63376475
Nodule 10.53 10.00 13 112310 21013 63355686
Dementia 10.52 10.00 63 112260 18731 63357968
Sinus arrhythmia 10.50 10.00 13 112310 1460 63375239
Opisthotonus 10.49 10.00 7 112316 349 63376350
Product prescribing error 10.45 10.00 81 112242 26208 63350491
Ultrasound abdomen abnormal 10.43 10.00 4 112319 59 63376640
Low birth weight baby 10.41 10.00 32 112291 7097 63369602
Intestinal dilatation 10.40 10.00 14 112309 1708 63374991
Vocal cord paresis 10.38 10.00 5 112318 132 63376567
Blood urea increased 10.34 10.00 81 112242 26298 63350401
Hyperpyrexia 10.30 10.00 21 112302 3611 63373088
Head titubation 10.27 10.00 10 112313 858 63375841
Ileus paralytic 10.27 10.00 24 112299 4527 63372172
Abnormal behaviour 10.24 10.00 69 112254 21357 63355342
Full blood count decreased 10.23 10.00 19 112304 26005 63350694
Mucosal erosion 10.20 10.00 13 112310 1503 63375196
Unresponsive to stimuli 10.20 10.00 98 112225 33718 63342981
Cholecystitis acute 10.19 10.00 35 112288 8225 63368474
Nephrocalcinosis 10.18 10.00 11 112312 1067 63375632
Supraventricular tachycardia 10.11 10.00 51 112272 14220 63362479
Musculoskeletal disorder 10.10 10.00 13 112310 20631 63356068
Acne 10.08 10.00 16 112307 23277 63353422
Status migrainosus 10.07 10.00 5 112318 141 63376558
Fluid retention 10.07 10.00 63 112260 59623 63317076
Respiratory tract congestion 10.06 10.00 10 112313 17822 63358877
Therapy interrupted 10.05 10.00 27 112296 32428 63344271
Procedural pain 10.04 10.00 69 112254 21500 63355199
Gastrointestinal mucosal exfoliation 10.01 10.00 5 112318 143 63376556

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 484.14 10.28 909 66305 135940 34753777
Vomiting 289.25 10.28 1087 66127 246534 34643183
Drug ineffective 238.52 10.28 319 66895 456432 34433285
Nausea 163.95 10.28 1165 66049 338743 34550974
General physical health deterioration 159.16 10.28 575 66639 127694 34762023
Dehydration 120.47 10.28 532 66682 129437 34760280
Decreased appetite 95.92 10.28 597 66617 165795 34723922
Drug abuse 93.07 10.28 37 67177 99059 34790658
Pyrexia 93.04 10.28 1013 66201 332000 34557717
Product dose omission issue 85.76 10.28 63 67151 119648 34770069
Constipation 81.74 10.28 496 66718 136486 34753231
Aplastic anaemia 81.50 10.28 97 67117 9619 34880098
Neutropenic sepsis 77.53 10.28 113 67101 13654 34876063
Dystonia 74.55 10.28 98 67116 10747 34878970
Serotonin syndrome 63.54 10.28 127 67087 19806 34869911
Drug intolerance 63.30 10.28 18 67196 59552 34830165
Neutropenia 62.61 10.28 515 66699 156263 34733454
Impaired gastric emptying 61.68 10.28 52 67162 3401 34886316
Abdominal pain 53.23 10.28 514 66700 163104 34726613
Systemic infection 52.12 10.28 57 67157 5155 34884562
Thrombocytopenia 50.90 10.28 491 66723 155756 34733961
Therapeutic product effect incomplete 50.59 10.28 17 67197 50524 34839193
Pneumonitis 48.99 10.28 160 67054 33718 34855999
Cytokine release syndrome 48.55 10.28 124 67090 22753 34866964
Lymphoid tissue hypoplasia 48.33 10.28 21 67193 397 34889320
Thymus hypoplasia 48.33 10.28 21 67193 397 34889320
Completed suicide 47.46 10.28 72 67142 98096 34791621
Malignant neoplasm progression 46.97 10.28 310 66904 87736 34801981
Peripheral swelling 46.60 10.28 47 67167 76494 34813223
Hypokalaemia 44.12 10.28 225 66989 57989 34831728
Off label use 42.73 10.28 560 66654 418964 34470753
Mucosal inflammation 41.85 10.28 166 67048 38456 34851261
Therapeutic product effect decreased 41.85 10.28 8 67206 34735 34854982
Premature baby 41.23 10.28 106 67108 19527 34870190
Meconium abnormal 40.15 10.28 12 67202 70 34889647
Anaemia 39.18 10.28 648 66566 232687 34657030
Treatment failure 38.31 10.28 21 67193 46676 34843041
Long QT syndrome 37.76 10.28 36 67178 2767 34886950
Arthralgia 37.33 10.28 184 67030 169857 34719860
Psoriasis 37.23 10.28 14 67200 38798 34850919
Alveolar lung disease 36.98 10.28 17 67197 369 34889348
Disseminated aspergillosis 35.93 10.28 21 67193 759 34888958
Ileus 35.60 10.28 90 67124 16409 34873308
Rash maculo-papular 34.71 10.28 127 67087 28324 34861393
Diarrhoea 34.54 10.28 987 66227 388925 34500792
Electrocardiogram QT prolonged 32.95 10.28 161 67053 40791 34848926
Leukopenia 32.71 10.28 220 66994 62636 34827081
Intentional product misuse 32.63 10.28 24 67190 45587 34844130
Foetal exposure during pregnancy 32.25 10.28 152 67062 37949 34851768
Pulmonary interstitial emphysema syndrome 32.05 10.28 17 67197 507 34889210
Death 32.00 10.28 556 66658 397493 34492224
Pneumonia 31.84 10.28 917 66297 361710 34528007
Aminoaciduria 31.68 10.28 14 67200 276 34889441
Rheumatoid arthritis 31.65 10.28 17 67197 38221 34851496
Sepsis 31.11 10.28 471 66743 166090 34723627
Neuroleptic malignant syndrome 30.85 10.28 90 67124 17844 34871873
Cachexia 30.75 10.28 52 67162 7134 34882583
Oesophagitis 30.36 10.28 74 67140 13187 34876530
Laparotomy 29.99 10.28 14 67200 315 34889402
Weight increased 29.96 10.28 86 67128 92947 34796770
Joint swelling 29.84 10.28 43 67171 59847 34829870
Genital erythema 29.48 10.28 13 67201 255 34889462
Mesothelioma 28.82 10.28 15 67199 430 34889287
Blood pressure fluctuation 28.00 10.28 7 67207 25242 34864475
Hepatic failure 27.95 10.28 136 67078 34395 34855322
Hypophagia 27.44 10.28 105 67109 23917 34865800
Toxicity to various agents 27.28 10.28 250 66964 200112 34689605
Necrotising enterocolitis neonatal 27.14 10.28 12 67202 237 34889480
Intentional product use issue 26.89 10.28 46 67168 59770 34829947
Device dislocation 26.45 10.28 45 67169 6204 34883513
Toxic epidermal necrolysis 25.88 10.28 96 67118 21550 34868167
Extrapyramidal disorder 25.46 10.28 68 67146 12812 34876905
Drug resistance 25.46 10.28 9 67205 25918 34863799
Wheezing 24.53 10.28 26 67188 41376 34848341
Haematopoietic stem cell mobilisation 24.37 10.28 10 67204 163 34889554
Pleural effusion 23.96 10.28 251 66963 81295 34808422
Colitis 23.93 10.28 139 67075 37611 34852106
Urticaria 23.69 10.28 53 67161 62324 34827393
Hyponatraemia 23.12 10.28 252 66962 82439 34807278
Intentional overdose 23.12 10.28 30 67184 43644 34846073
Malnutrition 23.04 10.28 65 67149 12644 34877073
Hiccups 22.80 10.28 56 67158 10026 34879691
Post concussion syndrome 22.79 10.28 9 67205 132 34889585
Gastrointestinal hypermotility 22.49 10.28 9 67205 137 34889580
Dysphagia 22.25 10.28 200 67014 62181 34827536
Arthropathy 22.21 10.28 12 67202 26895 34862822
Hyperthermia malignant 22.10 10.28 24 67190 2153 34887564
Congenital pneumonia 21.86 10.28 8 67206 94 34889623
Vascular access site occlusion 21.86 10.28 7 67207 53 34889664
Conjunctival irritation 21.35 10.28 8 67206 101 34889616
Impetigo 21.34 10.28 17 67197 1026 34888691
Pseudomonal sepsis 21.26 10.28 30 67184 3517 34886200
Heart rate decreased 21.07 10.28 18 67196 31727 34857990
Asthma 20.88 10.28 31 67183 42625 34847092
Cardiac failure congestive 20.70 10.28 86 67128 83184 34806533
Feeling abnormal 20.69 10.28 58 67156 63177 34826540
Delirium 20.55 10.28 150 67064 43841 34845876
Erectile dysfunction 20.54 10.28 7 67207 20630 34869087
Enteritis 20.33 10.28 47 67167 8095 34881622
Non-small cell lung cancer 20.26 10.28 31 67183 3909 34885808
Vocal cord inflammation 20.23 10.28 7 67207 69 34889648
Product use issue 19.93 10.28 59 67155 63157 34826560
Toxic encephalopathy 19.88 10.28 36 67178 5213 34884504
Tumour lysis syndrome 19.84 10.28 75 67139 16984 34872733
Wrong technique in product usage process 19.80 10.28 24 67190 35962 34853755
Condition aggravated 19.67 10.28 256 66958 191940 34697777
Loss of personal independence in daily activities 19.48 10.28 21 67193 33158 34856559
Disturbance in attention 19.41 10.28 13 67201 25932 34863785
Jaundice 19.31 10.28 116 67098 31766 34857951
Heart sounds abnormal 19.28 10.28 15 67199 875 34888842
Psoriatic arthropathy 19.22 10.28 7 67207 19791 34869926
Talipes 19.17 10.28 21 67193 1902 34887815
Musculoskeletal stiffness 19.11 10.28 38 67176 46642 34843075
Hepatocellular injury 19.07 10.28 89 67125 22122 34867595
Subileus 19.07 10.28 27 67187 3176 34886541
Abdominal neoplasm 19.01 10.28 11 67203 390 34889327
Electrocardiogram QT shortened 18.67 10.28 8 67206 146 34889571
Failure to thrive 18.64 10.28 47 67167 8554 34881163
Injection site pain 18.46 10.28 29 67185 38976 34850741
Septic shock 18.31 10.28 215 66999 71619 34818098
Headache 18.13 10.28 274 66940 200361 34689356
Stress 18.04 10.28 19 67195 30328 34859389
Stress cardiomyopathy 18 10.28 21 67193 2038 34887679
Hyperbilirubinaemia 17.92 10.28 72 67142 16771 34872946
Neutropenic infection 17.87 10.28 18 67196 1480 34888237
Superior vena cava occlusion 17.83 10.28 7 67207 101 34889616
Swelling 17.77 10.28 34 67180 42332 34847385
Suicide attempt 17.65 10.28 30 67184 39086 34850631
Synovitis 17.45 10.28 3 67211 14063 34875654
Tardive dyskinesia 17.39 10.28 36 67178 5754 34883963
Laryngeal cancer metastatic 17.35 10.28 6 67208 59 34889658
Clostridium difficile colitis 17.35 10.28 68 67146 15662 34874055
Hospitalisation 17.30 10.28 54 67160 56848 34832869
Blood pressure increased 16.73 10.28 100 67114 88002 34801715
Epileptic encephalopathy 16.37 10.28 8 67206 200 34889517
Hepatitis fulminant 16.20 10.28 29 67185 4161 34885556
Tachypnoea 16.10 10.28 74 67140 18278 34871439
Venous angioma of brain 16.08 10.28 5 67209 34 34889683
Chemotherapeutic drug level increased 16.01 10.28 8 67206 210 34889507
Therapy non-responder 15.91 10.28 32 67182 39114 34850603
Spleen congestion 15.89 10.28 9 67205 306 34889411
Gastrointestinal motility disorder 15.71 10.28 22 67192 2562 34887155
Gait disturbance 15.45 10.28 98 67116 85042 34804675
Cytokine storm 15.45 10.28 12 67202 698 34889019
Lower respiratory tract infection 15.42 10.28 109 67105 31528 34858189
Fall 15.40 10.28 286 66928 202599 34687118
Ileus paralytic 15.40 10.28 35 67179 5962 34883755
Bladder cancer 15.39 10.28 6 67208 16272 34873445
Neutrophil count decreased 15.33 10.28 158 67056 50946 34838771
Pulmonary embolism 15.28 10.28 250 66964 89496 34800221
COVID-19 15.27 10.28 87 67127 77463 34812254
Haematemesis 15.02 10.28 98 67116 27613 34862104
Blood alkaline phosphatase increased 14.96 10.28 107 67107 31068 34858649
Chills 14.64 10.28 228 66986 80815 34808902
Tumour pain 14.61 10.28 14 67200 1083 34888634
Diffuse alveolar damage 14.51 10.28 20 67194 2294 34887423
Dyschezia 14.49 10.28 16 67198 1462 34888255
Papillary renal cell carcinoma 14.46 10.28 8 67206 260 34889457
Myocardial infarction 14.40 10.28 156 67058 120929 34768788
Abdominal compartment syndrome 14.31 10.28 13 67201 940 34888777
Seborrhoeic dermatitis 14.24 10.28 17 67197 1691 34888026
Eczema asteatotic 14.24 10.28 8 67206 268 34889449
Blood creatine phosphokinase increased 14.04 10.28 42 67172 44815 34844902
Device related infection 14.02 10.28 68 67146 17169 34872548
Acute abdomen 13.95 10.28 18 67196 1937 34887780
Renal vasculitis 13.76 10.28 7 67207 191 34889526
Hypoalbuminaemia 13.73 10.28 53 67161 12121 34877596
Phaeochromocytoma crisis 13.72 10.28 5 67209 58 34889659
Adverse drug reaction 13.71 10.28 22 67192 29320 34860397
Rash 13.68 10.28 325 66889 222427 34667290
Immune-mediated hepatitis 13.67 10.28 19 67195 2196 34887521
Obstruction gastric 13.63 10.28 13 67201 1000 34888717
Diabetic gastroparesis 13.59 10.28 6 67208 118 34889599
Maternal drugs affecting foetus 13.52 10.28 26 67188 3939 34885778
Platelet count decreased 13.43 10.28 313 66901 119404 34770313
Pulmonary sepsis 13.35 10.28 19 67195 2246 34887471
Inappropriate schedule of product administration 13.30 10.28 68 67146 62228 34827489
Disease recurrence 13.29 10.28 13 67201 21477 34868240
Blood bilirubin increased 13.25 10.28 122 67092 38174 34851543
Underdose 13.16 10.28 5 67209 13775 34875942
Cardiac disorder 13.06 10.28 41 67173 43085 34846632
Low birth weight baby 12.95 10.28 39 67175 7866 34881851
Acute kidney injury 12.89 10.28 713 66501 304275 34585442
Performance status decreased 12.75 10.28 26 67188 4111 34885606
Psychotic disorder 12.73 10.28 17 67197 24435 34865282
Acute generalised exanthematous pustulosis 12.62 10.28 35 67179 6741 34882976
Memory impairment 12.55 10.28 42 67172 43276 34846441
Diabetes mellitus 12.54 10.28 47 67167 46826 34842891
Blood aluminium increased 12.48 10.28 3 67211 6 34889711
Nasopharyngitis 12.46 10.28 81 67133 69887 34819830
Platelet transfusion 12.41 10.28 15 67199 1511 34888206
Symmetrical drug-related intertriginous and flexural exanthema 12.33 10.28 8 67206 349 34889368
Cancer pain 12.32 10.28 20 67194 2652 34887065
Sopor 12.28 10.28 4 67210 12132 34877585
Product quality issue 12.13 10.28 9 67205 17026 34872691
Bacteraemia 12.10 10.28 72 67142 19645 34870072
Therapy cessation 12.05 10.28 9 67205 16964 34872753
Pericardial effusion 12.04 10.28 85 67129 24577 34865140
Dyskinesia 11.98 10.28 79 67135 22334 34867383
Hygroma colli 11.98 10.28 4 67210 35 34889682
Hypogonadism 11.96 10.28 18 67196 2237 34887480
Klebsiella bacteraemia 11.87 10.28 14 67200 1374 34888343
Pruritus 11.77 10.28 197 67017 141784 34747933
Retching 11.69 10.28 34 67180 6727 34882990
Cholangitis 11.63 10.28 40 67174 8649 34881068
Angina pectoris 11.62 10.28 27 67187 31336 34858381
Therapy interrupted 11.46 10.28 6 67208 13691 34876026
Road traffic accident 11.45 10.28 10 67204 17440 34872277
Restlessness 11.39 10.28 86 67128 25396 34864321
Pain in extremity 11.33 10.28 173 67041 126340 34763377
Nephrolithiasis 11.33 10.28 26 67188 30307 34859410
Injection site swelling 11.32 10.28 4 67210 11523 34878194
Ascites 11.25 10.28 138 67076 46433 34843284
Spinal cord injury thoracic 11.25 10.28 5 67209 100 34889617
Restrictive cardiomyopathy 11.22 10.28 10 67204 705 34889012
Bicytopenia 11.21 10.28 18 67196 2366 34887351
Neutropenic colitis 11.20 10.28 21 67193 3123 34886594
Prostate cancer 11.11 10.28 39 67175 39610 34850107
Therapeutic response decreased 11.05 10.28 25 67189 29288 34860429
Gastritis 11.04 10.28 76 67138 21797 34867920
Ventricular septal defect 11.00 10.28 24 67190 3977 34885740
Herpes zoster reactivation 10.99 10.28 7 67207 296 34889421
Blood cholesterol increased 10.98 10.28 14 67200 20529 34869188
Cholestasis 10.97 10.28 89 67125 26859 34862858
Oesophageal hypomotility 10.96 10.28 3 67211 12 34889705
Congenital nasal septum deviation 10.96 10.28 3 67211 12 34889705
Lenticulostriatal vasculopathy 10.96 10.28 3 67211 12 34889705
Paresis 10.96 10.28 17 67197 2169 34887548
Crepitations 10.95 10.28 21 67193 3175 34886542
No adverse event 10.89 10.28 17 67197 22910 34866807
Aortitis 10.82 10.28 8 67206 432 34889285
Type III immune complex mediated reaction 10.82 10.28 7 67207 304 34889413
Laboratory test abnormal 10.80 10.28 14 67200 20377 34869340
Skeletal dysplasia 10.69 10.28 5 67209 113 34889604
Intestinal ischaemia 10.54 10.28 36 67178 7758 34881959
Benign soft tissue neoplasm 10.53 10.28 5 67209 117 34889600
Aphthous ulcer 10.52 10.28 27 67187 4968 34884749
Aggression 10.47 10.28 39 67175 38925 34850792
Tumour perforation 10.46 10.28 7 67207 322 34889395
Heart rate irregular 10.44 10.28 9 67205 15798 34873919
Muscle spasms 10.43 10.28 93 67121 74908 34814809
Product use in unapproved indication 10.41 10.28 161 67053 117338 34772379
Body temperature increased 10.39 10.28 63 67151 17305 34872412
Device issue 10.30 10.28 3 67211 9774 34879943

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 895.97 9.67 1605 152985 229394 79360404
Vomiting 590.67 9.67 2701 151889 663127 78926671
Drug ineffective 470.93 9.67 864 153726 1080049 78509749
Nausea 350.03 9.67 3097 151493 954099 78635699
Joint swelling 277.87 9.67 106 154484 288540 79301258
Drug intolerance 250.89 9.67 99 154491 264020 79325778
Rheumatoid arthritis 250.05 9.67 50 154540 208420 79381378
Synovitis 248.72 9.67 10 154580 150724 79439074
General physical health deterioration 242.19 9.67 1116 153474 274122 79315676
Neutropenic sepsis 241.53 9.67 280 154310 26784 79563014
Hypokalaemia 236.18 9.67 714 153876 143326 79446472
Therapeutic product effect decreased 234.56 9.67 23 154567 163840 79425958
Pyrexia 225.81 9.67 2154 152436 676555 78913243
Arthropathy 219.81 9.67 39 154551 177072 79412726
Dehydration 215.10 9.67 1002 153588 247185 79342613
Dystonia 205.54 9.67 230 154360 21169 79568629
Constipation 199.58 9.67 1078 153512 281972 79307826
Arthralgia 197.54 9.67 518 154072 571285 79018513
Decreased appetite 192.87 9.67 1229 153361 341189 79248609
Hand deformity 178.10 9.67 5 154585 103914 79485884
Serotonin syndrome 176.71 9.67 315 154275 44712 79545086
Neutropenia 170.27 9.67 1046 153544 286664 79303134
Mucosal inflammation 168.01 9.67 419 154171 75161 79514637
Contraindicated product administered 165.13 9.67 50 154540 157488 79432310
Weight increased 160.06 9.67 181 154409 277205 79312593
Swelling 155.13 9.67 116 154474 216595 79373203
Aplastic anaemia 149.40 9.67 179 154411 17726 79572072
Abdominal pain 147.24 9.67 1272 153318 388297 79201501
Diarrhoea 147.11 9.67 2458 152132 878031 78711767
Completed suicide 145.48 9.67 157 154433 245610 79344188
Systemic lupus erythematosus 145.33 9.67 29 154561 121120 79468678
Product dose omission issue 144.47 9.67 160 154430 247377 79342421
Thrombocytopenia 142.45 9.67 941 153649 264318 79325480
Peripheral swelling 128.02 9.67 203 154387 269414 79320384
Malignant neoplasm progression 125.82 9.67 560 154030 135430 79454368
Anaemia 119.81 9.67 1354 153236 443661 79146137
Hyponatraemia 119.60 9.67 669 153921 177179 79412619
Glossodynia 117.33 9.67 28 154562 103309 79486489
Sinusitis 115.55 9.67 125 154465 195376 79394422
Musculoskeletal stiffness 111.30 9.67 105 154485 174903 79414895
Treatment failure 109.94 9.67 101 154489 170385 79419413
Nasopharyngitis 109.66 9.67 203 154387 253678 79336120
Pericarditis 109.36 9.67 33 154557 104203 79485595
Abdominal discomfort 107.83 9.67 201 154389 250526 79339272
Impaired gastric emptying 107.61 9.67 116 154474 10237 79579561
Electrocardiogram QT prolonged 103.90 9.67 398 154192 89988 79499810
Injection site pain 102.95 9.67 62 154528 129776 79460022
Psoriatic arthropathy 101.61 9.67 15 154575 77984 79511814
Torsade de pointes 99.87 9.67 153 154437 19159 79570639
Toxic epidermal necrolysis 97.84 9.67 246 154344 44335 79545463
Wound 95.64 9.67 53 154537 116126 79473672
Duodenal ulcer perforation 95.48 9.67 9 154581 66202 79523596
Hypomagnesaemia 94.85 9.67 251 154339 46660 79543138
Extrapyramidal disorder 94.60 9.67 163 154427 22516 79567282
Sepsis 94.57 9.67 866 153724 268562 79321236
Hepatic enzyme increased 90.96 9.67 133 154457 182477 79407321
Pulmonary embolism 89.07 9.67 604 153986 171050 79418748
Psoriasis 87.61 9.67 32 154558 89555 79500243
Cytokine release syndrome 86.83 9.67 206 154384 35792 79554006
Atelectasis 85.97 9.67 192 154398 32065 79557733
Phaeochromocytoma crisis 85.46 9.67 30 154560 307 79589491
Therapeutic product effect incomplete 85.43 9.67 89 154501 141556 79448242
Computerised tomogram thorax abnormal 85.11 9.67 55 154535 2364 79587434
Helicobacter infection 85.03 9.67 16 154574 69688 79520110
Colitis 82.78 9.67 321 154269 72986 79516812
Discomfort 82.67 9.67 73 154517 125544 79464254
Product use issue 79.36 9.67 181 154409 209641 79380157
Ileus 79.02 9.67 164 154426 26047 79563751
Muscle injury 77.53 9.67 4 154586 48557 79541241
Leukopenia 76.76 9.67 436 154154 116077 79473721
Neutrophil count decreased 74.48 9.67 370 154220 93589 79496209
Pneumonitis 74.09 9.67 273 154317 60587 79529211
Computerised tomogram thorax 73.49 9.67 29 154561 421 79589377
Blood pressure fluctuation 72.74 9.67 20 154570 67125 79522673
Rash maculo-papular 72.04 9.67 256 154334 55822 79533976
Sleep disorder due to general medical condition, insomnia type 71.45 9.67 3 154587 43553 79546245
Impaired healing 69.28 9.67 42 154548 87613 79502185
Intentional product use issue 67.99 9.67 119 154471 151993 79437805
Condition aggravated 65.99 9.67 637 153953 500487 79089311
Contusion 65.95 9.67 117 154473 148659 79441139
Acute kidney injury 65.55 9.67 1390 153200 518014 79071784
Arthritis 65.07 9.67 76 154514 114804 79474994
Systemic infection 64.72 9.67 87 154503 9665 79580133
Neovascularisation 63.71 9.67 36 154554 1209 79588589
Oculogyric crisis 61.95 9.67 49 154541 2903 79586895
Long QT syndrome 60.62 9.67 66 154524 5889 79583909
Fall 60.39 9.67 629 153961 487000 79102798
Blood cholesterol increased 59.62 9.67 45 154545 83675 79506123
Pneumonia 58.77 9.67 1685 152905 658561 78931237
Hepatocellular injury 57.52 9.67 213 154377 47380 79542418
Blood pressure increased 57.51 9.67 213 154377 211147 79378651
Parkinsonism 57.48 9.67 110 154480 16474 79573324
Knee arthroplasty 57.06 9.67 8 154582 43240 79546558
Oesophagitis 56.43 9.67 137 154453 24152 79565646
Therapeutic response decreased 55.73 9.67 30 154560 66823 79522975
C-reactive protein abnormal 55.10 9.67 13 154577 48354 79541444
Red blood cell sedimentation rate increased 55.08 9.67 11 154579 45931 79543867
Tardive dyskinesia 55.01 9.67 84 154506 10487 79579311
Asthma 54.83 9.67 112 154478 134983 79454815
Osteoarthritis 54.76 9.67 53 154537 87256 79502542
Neuroleptic malignant syndrome 54.23 9.67 146 154444 27413 79562385
Pain 54.11 9.67 1000 153590 702802 78886996
Folliculitis 53.77 9.67 20 154570 55360 79534438
Phaeochromocytoma 53.32 9.67 26 154564 641 79589157
Subileus 52.97 9.67 60 154530 5594 79584204
Hepatic failure 52.79 9.67 247 154343 60965 79528833
Drug abuse 52.53 9.67 152 154438 162539 79427259
Heart rate decreased 51.10 9.67 37 154553 70279 79519519
Pleural effusion 50.94 9.67 467 154123 144795 79445003
Injection site bruising 50.90 9.67 9 154581 40993 79548805
Injection site erythema 50.77 9.67 46 154544 78151 79511647
Cholecystitis chronic 50.54 9.67 78 154512 9828 79579970
Irritable bowel syndrome 50.34 9.67 29 154561 62212 79527586
Restlessness 49.58 9.67 200 154390 46292 79543506
Cholestasis 48.46 9.67 215 154375 51894 79537904
Urticaria 48.21 9.67 190 154400 185011 79404787
Lymphoid tissue hypoplasia 47.88 9.67 27 154563 903 79588895
Septic shock 47.82 9.67 404 154186 122397 79467401
Dysphagia 47.66 9.67 402 154188 121734 79468064
Injection site swelling 47.51 9.67 16 154574 47116 79542682
Electrolyte imbalance 46.76 9.67 149 154441 30732 79559066
Thymus hypoplasia 46.74 9.67 27 154563 946 79588852
Fibromyalgia 46.56 9.67 34 154556 64306 79525492
Neuropathy peripheral 46.41 9.67 448 154142 140857 79448941
Wrong technique in product usage process 46.15 9.67 45 154545 73830 79515968
Gastritis 46.14 9.67 200 154390 47793 79542005
Pancytopenia 45.67 9.67 507 154083 165238 79424560
Adverse drug reaction 45.61 9.67 37 154553 66355 79523443
Loss of personal independence in daily activities 45.15 9.67 81 154509 102499 79487299
Haematemesis 44.41 9.67 210 154380 52054 79537744
Hypoxia 44.16 9.67 347 154243 102896 79486902
Wheezing 43.79 9.67 101 154489 116563 79473235
Disseminated aspergillosis 43.27 9.67 27 154563 1091 79588707
Transfusion 42.98 9.67 114 154476 21216 79568582
Pain in extremity 42.76 9.67 476 154114 364062 79225736
Peripheral circulatory failure 42.66 9.67 27 154563 1119 79588679
Injection site reaction 42.25 9.67 27 154563 54758 79535040
Injection site pruritus 41.51 9.67 15 154575 42268 79547530
Mobility decreased 41.02 9.67 112 154478 122063 79467735
Hiccups 40.40 9.67 71 154519 9960 79579838
Malnutrition 40.12 9.67 115 154475 22387 79567411
Drug resistance 39.73 9.67 16 154574 42197 79547601
Aminoaciduria 39.64 9.67 18 154572 376 79589422
Respiratory dyskinesia 39.16 9.67 11 154579 49 79589749
Akathisia 38.84 9.67 82 154508 13177 79576621
Febrile bone marrow aplasia 38.70 9.67 81 154509 12939 79576859
Hypophagia 38.34 9.67 182 154408 45185 79544613
Intentional overdose 37.97 9.67 94 154496 105866 79483932
Inappropriate schedule of product administration 37.43 9.67 133 154457 133495 79456303
Hypoaesthesia 37.16 9.67 200 154390 179152 79410646
Toxicity to various agents 37.16 9.67 584 154006 420956 79168842
Tachycardia 37.01 9.67 516 154074 177252 79412546
Stevens-Johnson syndrome 36.72 9.67 162 154428 39004 79550794
Blood magnesium decreased 36.10 9.67 91 154499 16421 79573377
Dyskinesia 35.95 9.67 177 154413 44596 79545202
Ill-defined disorder 35.79 9.67 45 154545 65830 79523968
Small intestinal obstruction 35.45 9.67 125 154465 27147 79562651
Renal ischaemia 35.04 9.67 24 154566 1138 79588660
Aplasia 34.99 9.67 58 154532 7762 79582036
Tumour lysis syndrome 34.88 9.67 114 154476 23825 79565973
COVID-19 34.82 9.67 172 154418 157502 79432296
Cachexia 34.17 9.67 70 154520 11013 79578785
Alveolar lung disease 33.13 9.67 18 154572 559 79589239
Enterocolitis 32.80 9.67 81 154509 14431 79575367
Joint injury 32.71 9.67 10 154580 31325 79558473
Feeling abnormal 32.17 9.67 179 154411 159020 79430778
Gastroenteritis 31.97 9.67 141 154449 33941 79555857
Pulmonary interstitial emphysema syndrome 31.95 9.67 17 154573 506 79589292
Peritonitis 31.83 9.67 123 154467 27913 79561885
Adverse event 31.82 9.67 42 154548 60172 79529626
Cholecystitis 31.67 9.67 105 154485 22107 79567691
Gait disturbance 31.55 9.67 254 154336 207252 79382546
Stress 31.45 9.67 67 154523 79545 79510253
PCO2 increased 31.22 9.67 27 154563 1813 79587985
Hypersensitivity 30.89 9.67 342 154248 261897 79327901
PO2 increased 30.44 9.67 25 154565 1563 79588235
Genital erythema 30.09 9.67 14 154576 310 79589488
Intentional product misuse 29.92 9.67 90 154500 95075 79494723
Platelet count decreased 29.89 9.67 537 154053 194127 79395671
Non-small cell lung cancer 29.58 9.67 48 154542 6312 79583486
Blood pressure systolic increased 29.38 9.67 53 154537 66933 79522865
Device expulsion 29.36 9.67 7 154583 25854 79563944
Cataract 29.22 9.67 47 154543 62073 79527725
Alopecia 28.75 9.67 298 154292 231057 79358741
Cardiac arrest 28.67 9.67 481 154109 171615 79418183
Ascites 28.57 9.67 247 154343 75315 79514483
Hypocalcaemia 28.49 9.67 180 154410 49744 79540054
Skin candida 28.30 9.67 27 154563 2060 79587738
Hypophosphataemia 28.27 9.67 94 154496 19819 79569979
Headache 28.10 9.67 1011 153579 652761 78937037
Gamma-glutamyltransferase increased 28.08 9.67 192 154398 54488 79535310
Road traffic accident 27.97 9.67 26 154564 43638 79546160
Duodenal stenosis 27.95 9.67 18 154572 769 79589029
Emotional distress 27.92 9.67 152 154438 39817 79549981
Therapy non-responder 27.81 9.67 89 154501 92216 79497582
Cancer pain 27.75 9.67 42 154548 5203 79584595
Memory impairment 27.58 9.67 117 154473 111617 79478181
Foetal death 27.44 9.67 53 154537 7991 79581807
Mixed liver injury 27.17 9.67 51 154539 7527 79582271
Suicide attempt 27.11 9.67 77 154513 82855 79506943
Disease progression 27.05 9.67 505 154085 183857 79405941
Accidental exposure to product 26.19 9.67 14 154576 31308 79558490
Blood pressure diastolic decreased 26.01 9.67 13 154577 30203 79559595
Bursitis 25.86 9.67 19 154571 35825 79553973
Blood alkaline phosphatase increased 25.60 9.67 211 154379 63453 79526345
Left ventricular dysfunction 25.39 9.67 89 154501 19272 79570526
Nasal congestion 25.08 9.67 71 154519 76481 79513317
Illness 25.03 9.67 32 154558 46479 79543319
Diabetes insipidus 25.00 9.67 40 154550 5197 79584601
Secondary adrenocortical insufficiency 24.92 9.67 30 154560 2984 79586814
Infusion related reaction 24.89 9.67 306 154284 229931 79359867
Immune-mediated hepatitis 24.85 9.67 33 154557 3623 79586175
Grip strength decreased 24.67 9.67 6 154584 21863 79567935
Myocardial reperfusion injury 24.58 9.67 9 154581 105 79589693
Post concussion syndrome 24.56 9.67 15 154575 583 79589215
Intestinal perforation 24.51 9.67 82 154508 17344 79572454
Injection site rash 24.46 9.67 3 154587 17951 79571847
Polydipsia 24.37 9.67 45 154545 6560 79583238
Pancreatitis 24.29 9.67 221 154369 68354 79521444
Premature delivery 24.27 9.67 100 154490 23367 79566431
Heart rate increased 24.24 9.67 136 154454 120588 79469210
Mouth ulceration 24.17 9.67 142 154448 38252 79551546
Acute abdomen 23.96 9.67 30 154560 3107 79586691
Hypoalbuminaemia 23.82 9.67 93 154497 21204 79568594
Hepatitis fulminant 23.74 9.67 47 154543 7215 79582583
Infusion site streaking 23.65 9.67 14 154576 514 79589284
Abortion spontaneous 23.50 9.67 14 154576 29493 79560305
Pruritus 23.45 9.67 584 154006 394064 79195734
Excessive eye blinking 23.05 9.67 22 154568 1679 79588119
Carcinoid tumour of the stomach 22.94 9.67 10 154580 189 79589609
Alveolitis 22.87 9.67 34 154556 4146 79585652
Gelastic seizure 22.78 9.67 5 154585 5 79589793
Deep vein thrombosis 22.78 9.67 345 154245 120574 79469224
Blood bilirubin increased 22.73 9.67 212 154378 66020 79523778
Hyperprolactinaemia 22.72 9.67 36 154554 4640 79585158
Jaundice 22.64 9.67 179 154411 53170 79536628
Blood bicarbonate decreased 22.56 9.67 38 154552 5153 79584645
Neutropenic colitis 22.48 9.67 40 154550 5667 79584131
Off label use 22.40 9.67 1487 153103 905728 78684070
Abdominal pain upper 22.30 9.67 580 154010 223239 79366559
Haematopoietic stem cell mobilisation 22.15 9.67 10 154580 206 79589592
Therapy interrupted 22.11 9.67 17 154573 31324 79558474
Palmar-plantar erythrodysaesthesia syndrome 21.81 9.67 124 154466 33010 79556788
Encephalopathy 21.78 9.67 213 154377 67184 79522614
Injection site haemorrhage 21.13 9.67 14 154576 27856 79561942
Intentional self-injury 21.12 9.67 19 154571 32400 79557398
Ileus paralytic 21.01 9.67 53 154537 9567 79580231
Type 2 diabetes mellitus 20.99 9.67 50 154540 57072 79532726
Tumour pain 20.87 9.67 24 154566 2275 79587523
Herpes zoster 20.86 9.67 101 154489 92982 79496816
Urinary retention 20.83 9.67 184 154406 56446 79533352
Insomnia 20.79 9.67 342 154248 244828 79344970
Hypochloraemia 20.74 9.67 25 154565 2490 79587308
Urosepsis 20.74 9.67 104 154486 26391 79563407
Eructation 20.67 9.67 57 154533 10852 79578946
Cholangitis 20.59 9.67 63 154527 12713 79577085
Oropharyngeal spasm 20.58 9.67 12 154578 428 79589370
Hyponatraemic seizure 20.47 9.67 13 154577 542 79589256
Sedation complication 20.43 9.67 3 154587 15666 79574132
Bacteraemia 20.41 9.67 121 154469 32703 79557095
Apallic syndrome 20.17 9.67 16 154574 952 79588846
Device issue 20.04 9.67 14 154576 27094 79562704
Diabetic gastroparesis 19.98 9.67 11 154579 351 79589447
Joint range of motion decreased 19.95 9.67 21 154569 33261 79556537
Rash 19.57 9.67 919 153671 577439 79012359
Conjunctival irritation 19.57 9.67 8 154582 128 79589670
Drug clearance decreased 19.56 9.67 28 154562 3299 79586499
Cystitis noninfective 19.44 9.67 18 154572 1322 79588476
Multiple sclerosis relapse 19.36 9.67 38 154552 46495 79543303
Vascular access site occlusion 19.33 9.67 7 154583 79 79589719
Throat irritation 19.24 9.67 31 154559 40915 79548883
Fluid retention 19.20 9.67 70 154520 69739 79520059
Tachypnoea 19.17 9.67 117 154473 31946 79557852
Inflammation 19.16 9.67 105 154485 93648 79496150
Thymus disorder 19.12 9.67 10 154580 287 79589511
Cardiac failure congestive 19.11 9.67 180 154410 142222 79447576
Pseudomonal sepsis 19.04 9.67 39 154551 6135 79583663
Therapy cessation 19.04 9.67 27 154563 37535 79552263
Enterochromaffin cell hyperplasia 18.87 9.67 7 154583 85 79589713
Obstruction gastric 18.69 9.67 20 154570 1750 79588048
Myocardial infarction 18.67 9.67 248 154342 183881 79405917
Peripheral venous disease 18.67 9.67 4 154586 15905 79573893
Pituitary tumour benign 18.67 9.67 24 154566 2552 79587246
Aortic rupture 18.53 9.67 9 154581 220 79589578
Sopor 18.51 9.67 22 154568 32988 79556810
Blood pressure diastolic increased 18.47 9.67 3 154587 14539 79575259
Nail infection 18.42 9.67 23 154567 2376 79587422
Fluid replacement 18.38 9.67 12 154578 525 79589273
Foot deformity 18.38 9.67 12 154578 24062 79565736
Onychalgia 18.28 9.67 15 154575 937 79588861
Neutropenic infection 18.20 9.67 23 154567 2404 79587394
Clostridium difficile colitis 18.18 9.67 116 154474 32167 79557631
Ejection fraction decreased 18.10 9.67 122 154468 34455 79555343
Respiratory tract congestion 18.08 9.67 8 154582 19946 79569852
Tenosynovitis 18.08 9.67 4 154586 15550 79574248
Flail chest 17.97 9.67 7 154583 98 79589700
Hospitalisation 17.93 9.67 108 154482 94128 79495670
Immunodeficiency 17.80 9.67 10 154580 21758 79568040
Opisthotonus 17.80 9.67 13 154577 683 79589115
Failure to thrive 17.79 9.67 57 154533 11787 79578011
Hypotension 17.76 9.67 1033 153557 439284 79150514
Adrenal insufficiency 17.70 9.67 105 154485 28382 79561416
Intestinal obstruction 17.52 9.67 143 154447 42877 79546921
Hyperglycaemia 17.50 9.67 211 154379 70124 79519674
Malignant polyp 17.49 9.67 8 154582 170 79589628
Circulatory collapse 17.44 9.67 129 154461 37539 79552259
Enteritis 17.39 9.67 65 154525 14518 79575280
Radiation pneumonitis 17.37 9.67 29 154561 3904 79585894
Burning sensation 17.33 9.67 57 154533 58575 79531223
Product storage error 17.26 9.67 5 154585 16221 79573577
Incorrect dose administered 17.25 9.67 83 154507 76547 79513251
Gaze palsy 17.24 9.67 25 154565 2980 79586818
Toxic encephalopathy 17.14 9.67 55 154535 11385 79578413
Neuroglycopenia 17.02 9.67 11 154579 473 79589325
Pancreatic carcinoma metastatic 17.01 9.67 28 154562 3725 79586073
Hydronephrosis 16.97 9.67 73 154517 17381 79572417
Immune effector cell-associated neurotoxicity syndrome 16.94 9.67 36 154554 5812 79583986
Torticollis 16.93 9.67 22 154568 2365 79587433
Sciatica 16.72 9.67 24 154566 33198 79556600
Respiratory syncytial virus infection 16.71 9.67 48 154542 9354 79580444
Ocular hyperaemia 16.68 9.67 18 154572 28188 79561610
Joint effusion 16.67 9.67 7 154583 18007 79571791
Sudden death 16.67 9.67 87 154503 22424 79567374
Product quality issue 16.61 9.67 25 154565 33915 79555883
Intestinal ischaemia 16.54 9.67 60 154530 13210 79576588
Blister 16.47 9.67 150 154440 119326 79470472
Hypergastrinaemia 16.38 9.67 8 154582 198 79589600
Tooth disorder 16.36 9.67 16 154574 26217 79563581
Clonus 16.34 9.67 39 154551 6801 79582997
Impaired work ability 16.16 9.67 9 154581 19672 79570126
Alanine aminotransferase increased 16.10 9.67 421 154169 162149 79427649
Irritability 15.94 9.67 35 154555 41109 79548689
Tumour perforation 15.87 9.67 10 154580 411 79589387
Large intestine perforation 15.80 9.67 63 154527 14504 79575294
Klebsiella bacteraemia 15.78 9.67 24 154566 2986 79586812
Electrocardiogram T wave inversion 15.48 9.67 33 154557 5339 79584459
Non-cardiac chest pain 15.38 9.67 47 154543 9477 79580321
Seizure 15.37 9.67 477 154113 188357 79401441
Hypogonadism 15.35 9.67 18 154572 1742 79588056
Metastatic malignant melanoma 15.25 9.67 23 154567 2840 79586958
Spleen congestion 15.18 9.67 10 154580 444 79589354
Bronchitis 15.12 9.67 171 154419 130473 79459325
Dyspnoea 15.09 9.67 1889 152701 855136 78734662
Acute interstitial pneumonitis 15.04 9.67 15 154575 1208 79588590
Hyperbilirubinaemia 15.00 9.67 90 154500 24428 79565370
No adverse event 14.94 9.67 31 154559 37161 79552637
Colorectal cancer metastatic 14.89 9.67 15 154575 1223 79588575
Disturbance in social behaviour 14.86 9.67 31 154559 4939 79584859
Influenza 14.86 9.67 170 154420 129436 79460362
Muscle rigidity 14.84 9.67 77 154513 19805 79569993
Sinus disorder 14.84 9.67 13 154577 22451 79567347
Escherichia test positive 14.82 9.67 24 154566 3151 79586647
Venous angioma of brain 14.81 9.67 5 154585 45 79589753
Joint stiffness 14.80 9.67 36 154554 40794 79549004
Embolism 14.79 9.67 60 154530 13922 79575876
Myalgia 14.75 9.67 262 154328 185379 79404419
Pancreatitis acute 14.70 9.67 154 154436 49450 79540348
Musculoskeletal disorder 14.67 9.67 12 154578 21436 79568362
Mesothelioma 14.62 9.67 9 154581 355 79589443
Carpal tunnel syndrome 14.55 9.67 10 154580 19518 79570280
Bladder cancer 14.54 9.67 10 154580 19516 79570282
Urinary tract infection 14.53 9.67 661 153929 273851 79315947
Biliary dyskinesia 14.35 9.67 21 154569 2524 79587274
Laryngeal cancer metastatic 14.35 9.67 5 154585 50 79589748
Blood sodium decreased 14.34 9.67 112 154478 33143 79556655
Acanthosis 14.33 9.67 10 154580 489 79589309
Immune-mediated enterocolitis 14.30 9.67 30 154560 4800 79584998
Generalised tonic-clonic seizure 14.30 9.67 139 154451 43771 79546027
Suicidal ideation 14.26 9.67 88 154502 76252 79513546
Papillary renal cell carcinoma 14.20 9.67 8 154582 267 79589531
Heart rate irregular 14.20 9.67 26 154564 32653 79557145
Oxygen saturation abnormal 14.20 9.67 29 154561 4553 79585245
Lung perforation 14.08 9.67 6 154584 107 79589691
Multiple drug therapy 14.07 9.67 27 154563 4051 79585747
Paradoxical drug reaction 14.07 9.67 38 154552 7147 79582651
Dyspepsia 14.01 9.67 292 154298 108395 79481403
Poor quality sleep 14.00 9.67 14 154576 22708 79567090
Febrile infection 13.89 9.67 24 154566 3322 79586476
Underdose 13.86 9.67 27 154563 33124 79556674
Cardiac disorder 13.79 9.67 73 154517 65684 79524114
Oesophageal ulcer 13.77 9.67 37 154553 6938 79582860
Blood pH decreased 13.64 9.67 29 154561 4682 79585116
Gastric disorder 13.57 9.67 33 154557 37400 79552398
Hyperthermia malignant 13.54 9.67 22 154568 2895 79586903
Myoclonus 13.54 9.67 96 154494 27564 79562234
Stress cardiomyopathy 13.51 9.67 50 154540 11116 79578682
Muscle spasticity 13.50 9.67 13 154577 21462 79568336
Immune reconstitution inflammatory syndrome 13.43 9.67 5 154585 13836 79575962
Exostosis 13.42 9.67 8 154582 16850 79572948
Chills 13.37 9.67 406 154184 159828 79429970
Extravasation blood 13.36 9.67 9 154581 415 79589383
Sleep apnoea syndrome 13.35 9.67 32 154558 36446 79553352
Acne 13.33 9.67 20 154570 27170 79562628
Pulmonary sepsis 13.33 9.67 25 154565 3687 79586111
Gallbladder injury 13.25 9.67 14 154576 1207 79588591
Naevus haemorrhage 13.23 9.67 6 154584 125 79589673
Post transplant lymphoproliferative disorder 13.22 9.67 3 154587 11461 79578337
Gastric polyps 13.16 9.67 25 154565 3722 79586076
Superior vena cava occlusion 13.13 9.67 7 154583 209 79589589
Erectile dysfunction 13.10 9.67 6 154584 14658 79575140
Hypoacusis 13.09 9.67 24 154566 30126 79559672
Vitamin B12 decreased 13.08 9.67 24 154566 3481 79586317
Heart sounds abnormal 13.07 9.67 15 154575 1418 79588380
Disease recurrence 12.96 9.67 43 154547 44066 79545732
Mucosal erosion 12.89 9.67 19 154571 2299 79587499
Aspartate aminotransferase increased 12.86 9.67 356 154234 138285 79451513
Neutrophilic dermatosis 12.83 9.67 10 154580 580 79589218
Obstructive airways disorder 12.82 9.67 26 154564 31433 79558365
Thoracic operation 12.81 9.67 7 154583 220 79589578
Mania 12.76 9.67 10 154580 18250 79571548
Platelet transfusion 12.74 9.67 19 154571 2323 79587475
Basal cell carcinoma 12.74 9.67 34 154556 37341 79552457
Tracheal injury 12.71 9.67 5 154585 72 79589726
Leukoencephalopathy 12.69 9.67 39 154551 7890 79581908
Respiratory failure 12.67 9.67 449 154141 180462 79409336
Rhinovirus infection 12.61 9.67 39 154551 7914 79581884
Sinus tachycardia 12.59 9.67 118 154472 36790 79553008
Amylase increased 12.58 9.67 49 154541 11160 79578638
COVID-19 treatment 12.52 9.67 9 154581 461 79589337
Balance disorder 12.40 9.67 127 154463 98730 79491068
Neoplasm progression 12.40 9.67 154 154436 51528 79538270
Anxiety disorder 12.39 9.67 26 154564 4161 79585637
Vascular encephalopathy 12.35 9.67 10 154580 613 79589185
Chemotherapeutic drug level increased 12.27 9.67 8 154582 349 79589449
Porphyria acute 12.24 9.67 15 154575 1520 79588278
Musculoskeletal pain 12.23 9.67 133 154457 102221 79487577
Joint dislocation 12.19 9.67 9 154581 16930 79572868
Food allergy 12.15 9.67 3 154587 10821 79578977
Cyanosis 12.09 9.67 87 154503 25095 79564703
Sleep disorder 12.05 9.67 107 154483 85570 79504228
Upper gastrointestinal haemorrhage 12.04 9.67 128 154462 41252 79548546
Generalised oedema 12.02 9.67 83 154507 23626 79566172
Prostate cancer metastatic 11.99 9.67 25 154565 3982 79585816
Delusional disorder, persecutory type 11.90 9.67 9 154581 499 79589299
Vocal cord inflammation 11.87 9.67 7 154583 255 79589543
Lupus-like syndrome 11.87 9.67 6 154584 13851 79575947
Hypoglycaemic seizure 11.82 9.67 11 154579 813 79588985
Blood phosphorus decreased 11.81 9.67 34 154556 6634 79583164
Injection site mass 11.81 9.67 13 154577 20171 79569627
Blood creatinine increased 11.66 9.67 388 154202 154669 79435129
Performance status decreased 11.64 9.67 32 154558 6081 79583717
Abdominal sepsis 11.61 9.67 17 154573 2045 79587753
Agranulocytosis 11.60 9.67 136 154454 44894 79544904
Increased tendency to bruise 11.55 9.67 3 154587 10461 79579337
Back disorder 11.55 9.67 4 154586 11574 79578224
Seborrhoeic dermatitis 11.54 9.67 17 154573 2056 79587742
Limb injury 11.54 9.67 25 154565 29503 79560295
Prescribed underdose 11.52 9.67 25 154565 29489 79560309
Lung infiltration 11.49 9.67 80 154510 22832 79566966
Presyncope 11.48 9.67 126 154464 40928 79548870
Tooth fracture 11.47 9.67 4 154586 11526 79578272
Mood swings 11.41 9.67 13 154577 19867 79569931
Blood aluminium increased 11.36 9.67 3 154587 10 79589788
Lethargy 11.34 9.67 221 154369 81071 79508727
Confusional state 11.31 9.67 738 153852 317259 79272539
Peptic ulcer 11.28 9.67 32 154558 6191 79583607
Progressive multifocal leukoencephalopathy 11.26 9.67 14 154576 20586 79569212
Foetal malpresentation 11.21 9.67 5 154585 100 79589698
Galactorrhoea 11.21 9.67 23 154567 3623 79586175
Pericardial effusion 11.19 9.67 138 154452 46099 79543699
Coeliac disease 11.19 9.67 4 154586 11347 79578451
Escherichia bacteraemia 11.18 9.67 33 154557 6529 79583269
Device difficult to use 11.16 9.67 6 154584 13379 79576419
Toxic cardiomyopathy 11.16 9.67 8 154582 408 79589390
Pathogen resistance 11.15 9.67 7 154583 14335 79575463
Body temperature decreased 11.14 9.67 29 154561 32116 79557682
Blood urea increased 11.12 9.67 144 154446 48646 79541152
Pregnancy 11.11 9.67 22 154568 26829 79562969
Electrocardiogram change 11.09 9.67 13 154577 1258 79588540
Erysipelas 11.03 9.67 46 154544 10804 79578994
Calcium deficiency 11.01 9.67 11 154579 888 79588910
Faecaloma 10.97 9.67 48 154542 11516 79578282
Foot fracture 10.94 9.67 16 154574 21965 79567833
Aortitis 10.86 9.67 14 154576 1493 79588305
Transplant rejection 10.85 9.67 13 154577 19424 79570374
Vascular pain 10.85 9.67 11 154579 904 79588894
Abdominal tenderness 10.84 9.67 45 154545 10549 79579249
Eosinophilia 10.83 9.67 135 154455 45210 79544588
Restless arm syndrome 10.82 9.67 4 154586 48 79589750
Hepatitis acute 10.78 9.67 59 154531 15483 79574315
Liver function test abnormal 10.65 9.67 180 154410 64295 79525503
Dysuria 10.63 9.67 148 154442 50803 79538995
Porphyria 10.60 9.67 6 154584 202 79589596
Cholelithiasis 10.60 9.67 152 154438 52512 79537286
Plantar erythema 10.58 9.67 7 154583 313 79589485
Dyschezia 10.58 9.67 20 154570 2968 79586830
Thrombosis 10.57 9.67 108 154482 83992 79505806
Drug tolerance decreased 10.56 9.67 6 154584 12972 79576826
Blood pressure diastolic abnormal 10.55 9.67 13 154577 19189 79570609
Lower limb fracture 10.51 9.67 18 154572 23197 79566601
Visual impairment 10.50 9.67 121 154469 92010 79497788
Injection site warmth 10.49 9.67 8 154582 14799 79574999
Obesity 10.48 9.67 34 154556 35091 79554707
Prescribed overdose 10.41 9.67 38 154552 37845 79551953
Therapy partial responder 10.40 9.67 11 154579 17386 79572412
Sinus congestion 10.38 9.67 14 154576 19882 79569916
Haemorrhoids 10.38 9.67 94 154496 29034 79560764
Hypercholesterolaemia 10.37 9.67 18 154572 23077 79566721
Eye irritation 10.35 9.67 15 154575 20666 79569132
Injection site urticaria 10.34 9.67 6 154584 12820 79576978
Surgery 10.29 9.67 31 154559 32735 79557063
Procedural vomiting 10.29 9.67 10 154580 781 79589017
Night sweats 10.28 9.67 59 154531 52036 79537762
Spinal cord injury thoracic 10.26 9.67 5 154585 123 79589675
Injection site extravasation 10.25 9.67 3 154587 9666 79580132
Abdominal compartment syndrome 10.22 9.67 14 154576 1583 79588215
Anaphylactic reaction 10.15 9.67 223 154367 83520 79506278
Device breakage 10.12 9.67 4 154586 10671 79579127
Benign soft tissue neoplasm 10.12 9.67 5 154585 127 79589671
Peripheral sensory neuropathy 10.09 9.67 51 154539 12982 79576816
Numb chin syndrome 10.09 9.67 3 154587 17 79589781
Prostate cancer 10.07 9.67 32 154558 33236 79556562
Infection 10.07 9.67 375 154215 241337 79348461
Disability 10.04 9.67 11 154579 17109 79572689
Overdose 10.02 9.67 276 154314 183930 79405868
Paraesthesia oral 9.99 9.67 71 154519 20400 79569398
Retching 9.98 9.67 63 154527 17404 79572394
Blood disorder 9.97 9.67 37 154553 8236 79581562
Suspected suicide 9.97 9.67 4 154586 10572 79579226
Epileptic encephalopathy 9.91 9.67 8 154582 488 79589310
Blood parathyroid hormone decreased 9.90 9.67 4 154586 10532 79579266
Substance abuse 9.89 9.67 4 154586 10522 79579276
Blood zinc decreased 9.80 9.67 3 154587 19 79589779
Urea urine increased 9.80 9.67 3 154587 19 79589779
Adjustment disorder with anxiety 9.77 9.67 5 154585 137 79589661
Gastrointestinal stoma complication 9.77 9.67 18 154572 2619 79587179
Breast cancer female 9.76 9.67 5 154585 11456 79578342
Bone density decreased 9.72 9.67 7 154583 13340 79576458
Polyneuropathy 9.68 9.67 80 154510 24071 79565727

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A03FA01 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
PROPULSIVES
Propulsives
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D015259 Dopamine Agents
MeSH PA D018492 Dopamine Antagonists
MeSH PA D065127 Dopamine D2 Receptor Antagonists
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
FDA MoA N0000175799 Dopamine D2 Antagonists
FDA EPC N0000175800 Dopamine-2 Receptor Antagonist
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:48561 dopaminergic antagonists
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:55324 gastrointestinal drugs
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Diabetic gastroparesis indication 34140002
Intubation of gastrointestinal tract indication 235419001
Gastroesophageal reflux disease indication 235595009 DOID:8534
Chemotherapy-induced nausea and vomiting indication 236084000
Prevention of Post-Operative Nausea and Vomiting indication
Gastrointestinal Radiography Adjunct indication
Suicidal thoughts contraindication 6471006
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Cirrhosis of liver contraindication 19943007 DOID:5082
Parkinsonism contraindication 32798002
Depressive disorder contraindication 35489007
Hypertensive disorder contraindication 38341003 DOID:10763
Body fluid retention contraindication 43498006
Mechanical ileus contraindication 46420000
Chronic heart failure contraindication 48447003
Gastrointestinal perforation contraindication 51875005
Gastrointestinal hemorrhage contraindication 74474003
Tardive dyskinesia contraindication 102449007
Deficiency of cytochrome-b>5< reductase contraindication 124184009
Seizure disorder contraindication 128613002
Impaired renal function disorder contraindication 197663003
Anastomosis of intestine contraindication 235407009
Pheochromocytoma contraindication 302835009
Porphyria contraindication 418470004
Acquired torsion dystonia contraindication 433493000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.17 acidic
pKa2 8.94 Basic
pKa3 1.08 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 15MG BASE/SPRAY GIMOTI EVOKE PHARMA INC N209388 June 19, 2020 RX SPRAY, METERED NASAL 11020361 Dec. 22, 2029 NASAL ADMINISTRATION OF METOCLOPRAMIDE FOR TREATMENT OF DIABETIC GASTROPARESIS
EQ 15MG BASE/SPRAY GIMOTI EVOKE PHARMA INC N209388 June 19, 2020 RX SPRAY, METERED NASAL 11628150 Dec. 22, 2029 NASAL ADMINISTRATION OF METOCLOPRAMIDE FOR TREATMENT OF DIABETIC GASTROPARESIS
EQ 15MG BASE/SPRAY GIMOTI EVOKE PHARMA INC N209388 June 19, 2020 RX SPRAY, METERED NASAL 8334281 May 16, 2030 NASAL ADMINISTRATION OF METOCLOPRAMIDE FOR TREATMENT OF DIABETIC GASTROPARESIS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 15MG BASE/SPRAY GIMOTI EVOKE PHARMA INC N209388 June 19, 2020 RX SPRAY, METERED NASAL June 19, 2023 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST Ki 7.19 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 3A Ion channel ANTAGONIST Ki 6.70 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 4 GPCR AGONIST EC50 6 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 6.40 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 5.90 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 7.66 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR WOMBAT-PK
Aldehyde oxidase Enzyme IC50 4.51 WOMBAT-PK
Cytochrome P450 2D6 Enzyme IC50 6.10 DRUG MATRIX
Myeloperoxidase Enzyme IC50 6.46 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.02 CHEMBL
Serotonin 3 (5-HT3) receptor Ion channel Kd 7.30 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 5.99 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 5.98 DRUG MATRIX
D(2) dopamine receptor GPCR Ki 6.98 CHEMBL
D(2) dopamine receptor GPCR Ki 7.10 CHEMBL
D(2) dopamine receptor GPCR ANTAGONIST Ki 7.54 IUPHAR
5-hydroxytryptamine receptor 4 GPCR Ki 6.05 CHEMBL
D(3) dopamine receptor GPCR IC50 7.21 CHEMBL
Serotonin 3 (5-HT3) receptor Ion channel Ki 6.68 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR IC50 5.11 CHEMBL
Adrenergic receptor alpha-2 GPCR IC50 5.11 CHEMBL
Adrenergic receptor alpha-1 GPCR IC50 4.48 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR IC50 4.88 CHEMBL
Serotonin 3 receptor (5HT3) Ion channel Ki 6.70 CHEMBL
5-hydroxytryptamine receptor 4 GPCR Ki 6.26 CHEMBL
5-hydroxytryptamine receptor 4 GPCR AGONIST Ki 6 IUPHAR

External reference:

IDSource
4019835 VUID
N0000147923 NUI
D00726 KEGG_DRUG
54143-57-6 SECONDARY_CAS_RN
4017905 VANDF
4019835 VANDF
C0025853 UMLSCUI
CHEBI:107736 CHEBI
CHEMBL86 ChEMBL_ID
DB01233 DRUGBANK_ID
CHEMBL1200940 ChEMBL_ID
CHEMBL1256771 ChEMBL_ID
D008787 MESH_DESCRIPTOR_UI
4168 PUBCHEM_CID
241 IUPHAR_LIGAND_ID
1740 INN_ID
L4YEB44I46 UNII
267036 RXNORM
1062 MMSL
34842 MMSL
5099 MMSL
d00298 MMSL
001877 NDDF
004778 NDDF
31147000 SNOMEDCT_US
372776000 SNOMEDCT_US
56549003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0093-2203 TABLET 10 mg ORAL ANDA 26 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0093-2204 TABLET 5 mg ORAL ANDA 26 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0121-0576 SOLUTION 5 mg ORAL ANDA 28 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0121-0576 SOLUTION 5 mg ORAL ANDA 28 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0121-0576 SOLUTION 5 mg ORAL ANDA 28 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0121-1576 SOLUTION 5 mg ORAL ANDA 28 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0121-1576 SOLUTION 5 mg ORAL ANDA 28 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0121-1576 SOLUTION 5 mg ORAL ANDA 28 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0404-9910 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 13 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0404-9910 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 13 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0409-3414 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 15 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0409-3414 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 15 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0409-5255 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 23 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0409-5255 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 23 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0440-1771 TABLET 10 mg ORAL ANDA 22 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7698 TABLET 5 mg ORAL ANDA 27 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7698 TABLET 5 mg ORAL ANDA 27 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7698 TABLET 5 mg ORAL ANDA 27 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0615-8285 TABLET 10 mg ORAL ANDA 27 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0615-8285 TABLET 10 mg ORAL ANDA 27 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0615-8285 TABLET 10 mg ORAL ANDA 27 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0703-4502 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 23 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0703-4502 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 23 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 0703-4502 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 23 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 12634-112 TABLET 10 mg ORAL ANDA 22 sections
METOCLOPRAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-150 TABLET 5 mg ORAL ANDA 25 sections
METOCLOPRAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-151 TABLET 10 mg ORAL ANDA 25 sections
REGLAN HUMAN PRESCRIPTION DRUG LABEL 1 16590-906 TABLET 10 mg ORAL NDA 24 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 17856-0576 SOLUTION 5 mg ORAL ANDA 24 sections
Metoclopramide HUMAN PRESCRIPTION DRUG LABEL 1 21695-346 TABLET 10 mg ORAL ANDA 19 sections