acotiamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4908 185106-16-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • YM-443
  • Z-338
  • acotiamide
  • acotiamide hydrochloride
  • acotiamide hydrochloride hydrate
  • acofide
  • acotiamide HCl
A prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.
  • Molecular weight: 450.55
  • Formula: C21H30N4O5S
  • CLOGP: 4.20
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 3
  • TPSA: 113.02
  • ALOGS: -4.37
  • ROTB: 10

Drug dosage:

None

ADMET properties:

None

Approvals:

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Drug Use | Suggest Off label Use Form| |View source of the data|




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

External reference:

Pharmaceutical products:

None

acotiamide