acotiamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4908	185106-16-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: YM-443 Z-338 acotiamide acotiamide hydrochloride acotiamide hydrochloride hydrate acofide acotiamide HCl	A prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms. Molecular weight: 450.55 Formula: C21H30N4O5S CLOGP: 4.20 LIPINSKI: 0 HAC: 9 HDO: 3 TPSA: 113.02 ALOGS: -4.37 ROTB: 10

Molecule

Description

Molfile Inchi Smiles

Synonyms:

YM-443
Z-338
acotiamide
acotiamide hydrochloride
acotiamide hydrochloride hydrate
acofide
acotiamide HCl

A prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.

Molecular weight: 450.55
Formula: C21H30N4O5S
CLOGP: 4.20
LIPINSKI: 0
HAC: 9
HDO: 3
TPSA: 113.02
ALOGS: -4.37
ROTB: 10

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
March 25, 2013	PMDA	Zeria

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A03FA10	ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS PROPULSIVES Propulsives
MeSH PA	D018678	Cholinergic Agents
MeSH PA	D002800	Cholinesterase Inhibitors
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D005765	Gastrointestinal Agents
MeSH PA	D018377	Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Nonulcer dyspepsia	indication	3696007

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.18	acidic
pKa2	9.82	acidic
pKa3	13.5	acidic
pKa4	10.27	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Acetylcholinesterase	Enzyme	P22303	ACES_HUMAN	INHIBITOR	IC50	5.52		DRUG LABEL	SCIENTIFIC LITERATURE

External reference:

ID	Source
D08838	KEGG_DRUG
CHEBI:34523	CHEBI
CHEMBL2107723	ChEMBL_ID
CHEMBL2107308	ChEMBL_ID
C410959	MESH_SUPPLEMENTAL_RECORD_UI
773092-05-0	SECONDARY_CAS_RN
DB12482	DRUGBANK_ID
C4317155	UMLSCUI
8506	INN_ID
5282338	PUBCHEM_CID
D42OWK5383	UNII

Pharmaceutical products:

None