fluostigmine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1494 55-91-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • isoflurophate
  • phosphorofluoridic acid
  • difluorophate
  • diflupyl
  • diisopropyl fluorophosphate
  • fluostigmine
A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.
  • Molecular weight: 184.15
  • Formula: C6H14FO3P
  • CLOGP: 1.01
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 35.53
  • ALOGS: -1.43
  • ROTB: 4

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
April 2, 1957 FDA MERCK

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01EB07 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Parasympathomimetics
MeSH PA D018678 Cholinergic Agents
MeSH PA D002800 Cholinesterase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011480 Protease Inhibitors

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholinesterase Enzyme INHIBITOR Ki 5.22 CHEMBL CHEMBL
Lysosomal protective protein Enzyme IC50 5 CHEMBL
Prostaglandin G/H synthase 2 Enzyme Ki 6.77 PDSP
Acetylcholinesterase Enzyme Kd 4.15 CHEMBL
Acetylcholinesterase Enzyme IC50 6.32 CHEMBL
Liver carboxylesterase Enzyme IC50 7.30 CHEMBL

External reference:

IDSource
4017993 VUID
N0000146338 NUI
D00043 KEGG_DRUG
4017993 VANDF
C0022181 UMLSCUI
CHEBI:17941 CHEBI
CHEMBL1025 ChEMBL_ID
DB00677 DRUGBANK_ID
D007531 MESH_DESCRIPTOR_UI
5936 PUBCHEM_CID
12UHW9R67N UNII
6027 RXNORM
4927 MMSL
001712 NDDF
373521002 SNOMEDCT_US
68424007 SNOMEDCT_US

Pharmaceutical products:

None