paraoxon Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4683 311-45-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • paraoxon
  • oxyparathion
  • ethyl paraoxon
  • paraoxan
  • phosphachole
  • phosphacol
  • mintacol
An organophosphate cholinesterase inhibitor that is used as a pesticide.
  • Molecular weight: 275.20
  • Formula: C10H14NO6P
  • CLOGP: 1.88
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 0
  • TPSA: 90.58
  • ALOGS: -2.28
  • ROTB: 7

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01EB10 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Parasympathomimetics
MeSH PA D018678 Cholinergic Agents
MeSH PA D002800 Cholinesterase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D007306 Insecticides
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D010575 Pesticides
CHEBI has role CHEBI:38462 acetylcholine esterase inhibitor
CHEBI has role CHEBI:75771 Mus musculus metabolite

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 2 Enzyme IC50 7.23 CHEMBL
Carbonic anhydrase 1 Enzyme IC50 6.47 CHEMBL
Acetylcholinesterase Enzyme IC50 8 CHEMBL
Cholinesterase Enzyme IC50 8.15 CHEMBL
Carbonic anhydrase 13 Enzyme IC50 5.99 CHEMBL
Acetylcholinesterase Enzyme IC50 7.89 CHEMBL
Cannabinoid receptor 1 GPCR IC50 5.92 CHEMBL
Monoglyceride lipase Enzyme IC50 5.92 CHEMBL
Fatty-acid amide hydrolase 1 Enzyme IC50 6.27 CHEMBL

External reference:

IDSource
D10529 KEGG_DRUG
CHEBI:27827 CHEBI
CHEMBL23838 ChEMBL_ID
C121104 MESH_SUPPLEMENTAL_RECORD_UI
DB13495 DRUGBANK_ID
Q9CX8P80JW UNII
9395 PUBCHEM_CID
D010261 MESH_DESCRIPTOR_UI
C0030480 UMLSCUI

Pharmaceutical products:

None