echothiophate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
982 6736-03-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • echothiophate
  • ecothiopate
  • ecothiophate
  • phospholine
  • echothiophate iodide
A potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma.
  • Molecular weight: 256.32
  • Formula: C9H23NO3PS
  • CLOGP: -2.82
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 35.53
  • ALOGS: -2.99
  • ROTB: 8

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 ml None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 27, 1960 FDA WYETH PHARMS INC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01EB03 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Parasympathomimetics
FDA CS M0011640 Iodine
FDA MoA N0000000177 Cholinesterase Inhibitors
CHEBI has role CHEBI:37733 BChE inhibitor
CHEBI has role CHEBI:51068 Miotico
MeSH PA D018678 Cholinergic Agents
MeSH PA D002800 Cholinesterase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D008916 Miotics
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D010277 Parasympathomimetics
MeSH PA D018373 Peripheral Nervous System Agents
FDA EPC N0000175723 Cholinesterase Inhibitor

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Esotropia indication 16596007 DOID:9840
Glaucoma indication 23986001 DOID:1686
Stargardt's disease indication 70099003
Open-angle glaucoma indication 84494001 DOID:1067
Irritable bowel syndrome contraindication 10743008 DOID:9778
Peptic ulcer contraindication 13200003 DOID:750
Increased gastric tonus contraindication 18644006
Muscle weakness contraindication 26544005
Parkinsonism contraindication 32798002
Hypertensive disorder contraindication 38341003 DOID:10763
Retinal detachment contraindication 42059000 DOID:5327
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Diarrhea contraindication 62315008
Iritis contraindication 65074000 DOID:1406
Disturbance of salivary secretion contraindication 78948009
Decreased respiratory function contraindication 80954004
Epilepsy contraindication 84757009 DOID:1826
Uveitis contraindication 128473001 DOID:13141
Urinary incontinence contraindication 165232002
Asthma contraindication 195967001 DOID:2841
Pregnancy, function contraindication 289908002
Hyperhidrosis contraindication 312230002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial infarction in recovery phase contraindication 418044006

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholinesterase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
513-10-0 SECONDARY_CAS_RN
4018498 VANDF
C0301366 UMLSCUI
CHEBI:4753 CHEBI
CHEMBL1201341 ChEMBL_ID
DB01057 DRUGBANK_ID
CHEMBL1200367 ChEMBL_ID
10548 PUBCHEM_CID
9074 IUPHAR_LIGAND_ID
C061212 MESH_SUPPLEMENTAL_RECORD_UI
662 INN_ID
0F350BVT6S UNII
3740 RXNORM
4649 MMSL
001711 NDDF
004689 NDDF
387073002 SNOMEDCT_US
387339003 SNOMEDCT_US
60682004 SNOMEDCT_US
D004456 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None