Stem definition | Drug id | CAS RN |
---|---|---|
982 | 6736-03-4 |
Dose | Unit | Route |
---|---|---|
0.20 | ml | None |
None
Date | Agency | Company | Orphan |
---|---|---|---|
June 27, 1960 | FDA | WYETH PHARMS INC |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | S01EB03 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Parasympathomimetics |
FDA CS | M0011640 | Iodine |
FDA MoA | N0000000177 | Cholinesterase Inhibitors |
CHEBI has role | CHEBI:37733 | EC 3.1.1.8 inhibitor |
CHEBI has role | CHEBI:51068 | Miotico |
MeSH PA | D018678 | Cholinergic Agents |
MeSH PA | D002800 | Cholinesterase Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D008916 | Miotics |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D010277 | Parasympathomimetics |
MeSH PA | D018373 | Peripheral Nervous System Agents |
FDA EPC | N0000175723 | Cholinesterase Inhibitor |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Esotropia | indication | 16596007 | DOID:9840 |
Glaucoma | indication | 23986001 | DOID:1686 |
Stargardt's disease | indication | 70099003 | |
Open-angle glaucoma | indication | 84494001 | DOID:1067 |
Irritable bowel syndrome | contraindication | 10743008 | DOID:9778 |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Increased gastric tonus | contraindication | 18644006 | |
Muscle weakness | contraindication | 26544005 | |
Parkinsonism | contraindication | 32798002 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Retinal detachment | contraindication | 42059000 | DOID:5327 |
Low blood pressure | contraindication | 45007003 | |
Bradycardia | contraindication | 48867003 | |
Diarrhea | contraindication | 62315008 | |
Iritis | contraindication | 65074000 | DOID:1406 |
Disturbance of salivary secretion | contraindication | 78948009 | |
Decreased respiratory function | contraindication | 80954004 | |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Uveitis | contraindication | 128473001 | DOID:13141 |
Urinary incontinence | contraindication | 165232002 | |
Asthma | contraindication | 195967001 | DOID:2841 |
Pregnancy, function | contraindication | 289908002 | |
Hyperhidrosis | contraindication | 312230002 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Myocardial infarction in recovery phase | contraindication | 418044006 |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Acetylcholinesterase | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
ID | Source |
---|---|
513-10-0 | SECONDARY_CAS_RN |
4018498 | VANDF |
C0301366 | UMLSCUI |
CHEBI:4753 | CHEBI |
CHEMBL1201341 | ChEMBL_ID |
DB01057 | DRUGBANK_ID |
CHEMBL1200367 | ChEMBL_ID |
C061212 | MESH_SUPPLEMENTAL_RECORD_UI |
10548 | PUBCHEM_CID |
9074 | IUPHAR_LIGAND_ID |
0F350BVT6S | UNII |
3740 | RXNORM |
4649 | MMSL |
001711 | NDDF |
004689 | NDDF |
387073002 | SNOMEDCT_US |
387339003 | SNOMEDCT_US |
60682004 | SNOMEDCT_US |
D004456 | MESH_DESCRIPTOR_UI |
662 | INN_ID |
None