acetylcholine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 65 | 51-84-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. Miochol-E (acetylcholine chloride intraocular solution) is used to obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 100 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 9, 1973 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | S01EB09 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Parasympathomimetics |
| FDA MoA | N0000175369 | Cholinergic Agonists |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D018678 | Cholinergic Agents |
| MeSH PA | D018679 | Cholinergic Agonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D014665 | Vasodilator Agents |
| CHEBI has role | CHEBI:24621 | hormones |
| CHEBI has role | CHEBI:25512 | neurotransmitters |
| CHEBI has role | CHEBI:35620 | vasodilator agents |
| CHEBI has role | CHEBI:38325 | muscarinic agonists |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
| FDA EPC | N0000175884 | Cholinergic Receptor Agonist |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Glaucoma | indication | 23986001 | DOID:1686 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M3 | GPCR | AGONIST | EC50 | 6.66 | CHEMBL | CHEMBL | |||
| Muscarinic acetylcholine receptor M2 | GPCR | AGONIST | Ki | 6.50 | IUPHAR | ||||
| Muscarinic acetylcholine receptor M4 | GPCR | AGONIST | Ki | 5.60 | IUPHAR | ||||
| Muscarinic acetylcholine receptor M5 | GPCR | EC50 | 6.10 | CHEMBL | |||||
| Neuronal acetylcholine receptor subunit alpha-7 | Ion channel | Ki | 5.10 | CHEMBL | |||||
| Neuronal acetylcholine receptor; alpha4/beta2 | Ion channel | EC50 | 5.80 | CHEMBL | |||||
| Muscarinic acetylcholine receptor M1 | GPCR | EC50 | 6.11 | CHEMBL | |||||
| Acetylcholine-binding protein | Unclassified | Ki | 5.50 | CHEMBL | |||||
| Acetylcholine receptor subunit delta | Ion channel | Ki | 7.37 | CHEMBL | |||||
| Neuronal acetylcholine receptor subunit alpha-7 | Ion channel | Ki | 5.45 | CHEMBL | |||||
| Neuronal acetylcholine receptor; alpha2/beta2 | Ion channel | Ki | 7.96 | CHEMBL | |||||
| Neuronal acetylcholine receptor; alpha3/beta2 | Ion channel | Ki | 7.39 | CHEMBL | |||||
| Neuronal acetylcholine receptor; alpha3/beta4 | Ion channel | Ki | 6.21 | CHEMBL | |||||
| Neuronal acetylcholine receptor; alpha4/beta2 | Ion channel | Ki | 8.12 | CHEMBL | |||||
| Neuronal acetylcholine receptor; alpha4/beta4 | Ion channel | Ki | 7.24 | CHEMBL | |||||
| Muscarinic acetylcholine receptor | GPCR | IC50 | 7.92 | CHEMBL | |||||
| Nicotinic acetylcholine receptor alpha8 subunit | Ion channel | EC50 | 4.94 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019594 | VUID |
| N0000147690 | NUI |
| D00999 | KEGG_DRUG |
| 60-31-1 | SECONDARY_CAS_RN |
| 194 | RXNORM |
| C0001041 | UMLSCUI |
| CHEBI:15355 | CHEBI |
| ACH | PDB_CHEM_ID |
| CHEMBL1184 | ChEMBL_ID |
| CHEMBL667 | ChEMBL_ID |
| DB03128 | DRUGBANK_ID |
| D000109 | MESH_DESCRIPTOR_UI |
| 187 | PUBCHEM_CID |
| 294 | IUPHAR_LIGAND_ID |
| N9YNS0M02X | UNII |
| 13525006 | SNOMEDCT_US |
| 387496009 | SNOMEDCT_US |
| 57308006 | SNOMEDCT_US |
| 4019546 | VANDF |
| 4019594 | VANDF |
| 438 | INN_ID |
| 4126 | MMSL |
| 72383 | MMSL |
| 001697 | NDDF |
| 004684 | NDDF |
Pharmaceutical products:
None