haloperidol ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antipsychotics, haloperidol derivatives 1353 52-86-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • haloperidol
  • aloperidin
  • haloperin
  • sigaperidol
  • haloperidol lactate
A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
  • Molecular weight: 375.87
  • Formula: C21H23ClFNO2
  • CLOGP: 3.85
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 40.54
  • ALOGS: -4.93
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
8 mg O
8 mg P
3.30 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.04 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.57 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 17 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.08 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 35 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 12, 1967 FDA ORTHO MCNEIL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 1473.28 14.35 479 37381 10651 50556613
Extrapyramidal disorder 1260.97 14.35 432 37428 11338 50555926
Intentional self-injury 751.78 14.35 360 37500 22752 50544512
Catatonia 434.61 14.35 146 37714 3590 50563674
Akathisia 430.76 14.35 179 37681 8050 50559214
Drug interaction 413.40 14.35 619 37241 199002 50368262
Dystonia 385.21 14.35 185 37675 11741 50555523
Sopor 356.08 14.35 208 37652 19671 50547593
Muscle rigidity 340.46 14.35 160 37700 9669 50557595
Hyperprolactinaemia 289.38 14.35 105 37755 3260 50564004
Agitation 286.63 14.35 270 37590 53114 50514150
Psychotic disorder 285.76 14.35 187 37673 21625 50545639
Delusion 267.61 14.35 139 37721 10430 50556834
Hallucination, auditory 259.95 14.35 137 37723 10591 50556673
Salivary hypersecretion 252.27 14.35 115 37745 6476 50560788
Delirium 235.89 14.35 209 37651 37983 50529281
Parkinsonism 220.10 14.35 115 37745 8732 50558532
Aggression 217.30 14.35 156 37704 20960 50546304
Electrocardiogram QT prolonged 213.18 14.35 227 37633 51659 50515605
Intentional overdose 208.05 14.35 245 37615 62259 50505005
Somnolence 198.79 14.35 389 37471 154596 50412668
Tardive dyskinesia 196.60 14.35 100 37760 7179 50560085
Suicide attempt 189.35 14.35 213 37647 51519 50515745
Arthralgia 188.98 14.35 48 37812 438654 50128610
Pain 186.53 14.35 101 37759 578802 49988462
Psychomotor hyperactivity 184.34 14.35 104 37756 9197 50558067
Sedation 184.01 14.35 165 37695 30445 50536819
Hypothermia 167.13 14.35 107 37753 11909 50555355
Fatigue 165.73 14.35 172 37688 707429 49859835
Weight increased 164.63 14.35 423 37437 201468 50365796
Schizophrenia 161.07 14.35 88 37772 7309 50559955
Overdose 157.57 14.35 274 37586 99453 50467811
Coma 152.39 14.35 200 37660 56679 50510585
Restlessness 147.95 14.35 134 37726 25039 50542225
Joint swelling 144.81 14.35 10 37850 245276 50321988
Bradykinesia 142.12 14.35 66 37794 3877 50563387
Torsade de pointes 139.39 14.35 95 37765 11740 50555524
Headache 137.63 14.35 107 37753 506428 50060836
Tremor 133.56 14.35 277 37583 114626 50452638
Abnormal behaviour 128.18 14.35 111 37749 19547 50547717
Blood creatine phosphokinase increased 127.52 14.35 126 37734 26241 50541023
Rheumatoid arthritis 126.44 14.35 6 37854 202544 50364720
Alopecia 121.62 14.35 19 37841 245028 50322236
Dyskinesia 119.89 14.35 125 37735 27736 50539528
Confusional state 118.27 14.35 356 37504 185572 50381692
Rash 111.81 14.35 98 37762 437373 50129891
Hypertonia 111.43 14.35 56 37804 3917 50563347
Dysarthria 110.34 14.35 138 37722 37265 50529999
Hallucination 109.67 14.35 154 37706 46503 50520761
Sluggishness 108.71 14.35 57 37803 4356 50562908
Abdominal discomfort 106.20 14.35 22 37838 231619 50335645
Infusion related reaction 105.88 14.35 5 37855 169552 50397712
Swelling 105.71 14.35 13 37847 200859 50366405
Arthropathy 104.29 14.35 3 37857 157903 50409361
Oculogyric crisis 102.15 14.35 39 37821 1398 50565866
Depressed level of consciousness 101.24 14.35 157 37703 51796 50515468
Cogwheel rigidity 100.93 14.35 41 37819 1736 50565528
Galactorrhoea 97.20 14.35 50 37810 3673 50563591
Mutism 96.45 14.35 37 37823 1344 50565920
Tachycardia 93.82 14.35 221 37639 99542 50467722
Toxicity to various agents 92.11 14.35 358 37502 212141 50355123
Altered state of consciousness 90.16 14.35 96 37764 21814 50545450
Sinusitis 89.82 14.35 11 37849 170547 50396717
Paranoia 89.73 14.35 69 37791 10279 50556985
Pruritus 88.80 14.35 51 37809 283517 50283747
Pain in extremity 88.44 14.35 47 37813 272818 50294446
Systemic lupus erythematosus 88.26 14.35 4 37856 140618 50426646
Bradyphrenia 86.08 14.35 55 37805 6097 50561167
Nasopharyngitis 85.01 14.35 20 37840 192907 50374357
Blood prolactin increased 84.91 14.35 43 37817 3056 50564208
Embolism venous 84.02 14.35 40 37820 2485 50564779
Treatment noncompliance 80.67 14.35 106 37754 30044 50537220
Peripheral swelling 80.26 14.35 27 37833 205909 50361355
Suicidal ideation 78.20 14.35 145 37715 55240 50512024
Mania 78.04 14.35 65 37795 10851 50556413
Stupor 76.27 14.35 42 37818 3541 50563723
Torticollis 75.07 14.35 33 37827 1703 50565561
Drug abuse 75.06 14.35 149 37711 59697 50507567
Drug intolerance 73.57 14.35 36 37824 219068 50348196
Psychomotor retardation 72.58 14.35 40 37820 3378 50563886
Pneumonia aspiration 72.34 14.35 102 37758 30902 50536362
Rhabdomyolysis 69.21 14.35 113 37747 38914 50528350
Psychotic symptom 68.96 14.35 28 37832 1184 50566080
Drug level increased 68.17 14.35 78 37782 19190 50548074
Disorientation 67.39 14.35 106 37754 35378 50531886
Negativism 65.89 14.35 20 37840 350 50566914
Persecutory delusion 65.05 14.35 33 37827 2354 50564910
Encephalitis autoimmune 64.58 14.35 27 37833 1231 50566033
Contraindicated product administered 64.51 14.35 16 37844 148942 50418322
Urinary retention 63.84 14.35 88 37772 26102 50541162
Ileus paralytic 63.69 14.35 39 37821 4011 50563253
Hypersensitivity 61.40 14.35 43 37817 215118 50352146
Wound 60.41 14.35 5 37855 105789 50461475
Pleurothotonus 60.40 14.35 26 37834 1275 50565989
Nausea 60.14 14.35 298 37562 705100 49862164
Toxic epidermal necrolysis 59.59 14.35 76 37784 20916 50546348
Drooling 59.47 14.35 35 37825 3349 50563915
Hypernatraemia 58.89 14.35 44 37816 6277 50560987
Dyspnoea 57.88 14.35 213 37647 547395 50019869
Mental impairment 57.19 14.35 57 37803 11987 50555277
Stereotypy 56.86 14.35 18 37842 364 50566900
Gestational diabetes 56.60 14.35 46 37814 7419 50559845
Injection site pain 56.42 14.35 8 37852 111016 50456248
Hyponatraemia 55.37 14.35 178 37682 95961 50471303
Hyperthermia 53.30 14.35 45 37815 7651 50559613
Cardiac arrest 52.90 14.35 160 37700 83491 50483773
Discomfort 52.37 14.35 9 37851 108371 50458893
Granulocytopenia 52.31 14.35 38 37822 5193 50562071
Diarrhoea 52.18 14.35 245 37615 588231 49979033
Product dose omission issue 52.09 14.35 37 37823 183801 50383463
Treatment failure 51.96 14.35 19 37841 137618 50429646
Dysphagia 51.61 14.35 151 37709 77367 50489897
Oromandibular dystonia 50.39 14.35 17 37843 423 50566841
Lethargy 50.27 14.35 113 37747 49319 50517945
Accidental exposure to product by child 48.99 14.35 21 37839 1019 50566245
Serotonin syndrome 48.56 14.35 75 37785 24638 50542626
Miosis 48.09 14.35 39 37821 6271 50560993
Arthritis 47.11 14.35 5 37855 86716 50480548
Hyperammonaemic encephalopathy 46.91 14.35 25 37835 1974 50565290
Mental disorder 46.41 14.35 69 37791 21922 50545342
Echolalia 46.33 14.35 13 37847 170 50567094
Cognitive disorder 46.15 14.35 102 37758 44021 50523243
Unresponsive to stimuli 45.54 14.35 82 37778 30527 50536737
Back pain 45.22 14.35 59 37801 219971 50347293
Schizoaffective disorder 44.60 14.35 25 37835 2181 50565083
Bradycardia 44.32 14.35 127 37733 64299 50502965
Antipsychotic drug level increased 44 14.35 28 37832 3081 50564183
Urticaria 42.38 14.35 22 37838 129539 50437725
Cough 41.57 14.35 73 37787 241191 50326073
Disturbance in attention 40.72 14.35 79 37781 31107 50536157
Distractibility 39.90 14.35 14 37846 393 50566871
Hallucination, visual 39.33 14.35 55 37805 16527 50550737
Akinesia 38.75 14.35 20 37840 1479 50565785
Hypoxic-ischaemic encephalopathy 38.62 14.35 28 37832 3814 50563450
Contusion 38.27 14.35 18 37842 112165 50455099
Mental status changes 38.09 14.35 84 37776 36188 50531076
Impaired healing 37.97 14.35 4 37856 69782 50497482
White blood cell count increased 37.96 14.35 92 37768 42148 50525116
Hyperreflexia 37.67 14.35 31 37829 5087 50562177
Eosinophilic myocarditis 37.49 14.35 13 37847 352 50566912
Waxy flexibility 37.06 14.35 10 37850 112 50567152
Pericarditis 37 14.35 7 37853 78682 50488582
Hallucinations, mixed 36.98 14.35 28 37832 4075 50563189
Injection site erythema 36.69 14.35 6 37854 74930 50492334
Pulmonary embolism 36.61 14.35 162 37698 101542 50465722
Chest discomfort 36.36 14.35 12 37848 92710 50474554
Myalgia 35.22 14.35 25 37835 124294 50442970
Psoriasis 34.98 14.35 5 37855 68995 50498269
Metabolic syndrome 34.90 14.35 18 37842 1329 50565935
Abdominal pain upper 34.52 14.35 41 37819 159268 50407996
Paraesthesia 34.31 14.35 24 37836 120219 50447045
Herpes zoster 33.92 14.35 6 37854 70780 50496484
Somatic symptom disorder of pregnancy 33.75 14.35 9 37851 96 50567168
Negative symptoms in schizophrenia 33.26 14.35 9 37851 102 50567162
Sexually inappropriate behaviour 33.02 14.35 9 37851 105 50567159
Illogical thinking 32.87 14.35 8 37852 57 50567207
Feeling guilty 32.77 14.35 13 37847 517 50566747
Respiratory failure 32.63 14.35 145 37715 91036 50476228
Electroencephalogram abnormal 31.80 14.35 24 37836 3475 50563789
Inappropriate antidiuretic hormone secretion 31.78 14.35 44 37816 13099 50554165
Therapeutic product effect decreased 31.68 14.35 33 37827 136017 50431247
Speech disorder 31.49 14.35 77 37783 35471 50531793
Myocarditis 31.24 14.35 34 37826 7913 50559351
Sudden death 31.13 14.35 36 37824 8955 50558309
Hypersexuality 31.12 14.35 12 37848 442 50566822
Opisthotonus 31.05 14.35 11 37849 318 50566946
Nuchal rigidity 31.02 14.35 13 37847 596 50566668
Impulsive behaviour 30.78 14.35 17 37843 1441 50565823
Musculoskeletal pain 30.75 14.35 8 37852 72169 50495095
Sinus bradycardia 30.19 14.35 43 37817 13140 50554124
Behaviour disorder 30.16 14.35 20 37840 2360 50564904
Dizziness 30.12 14.35 145 37715 346224 50221040
Influenza 29.58 14.35 15 37845 89523 50477741
Social avoidant behaviour 29.53 14.35 21 37839 2776 50564488
Nephrogenic diabetes insipidus 29.44 14.35 14 37846 867 50566397
Neutrophil count increased 29.18 14.35 44 37816 14151 50553113
Chest pain 29.12 14.35 55 37805 176827 50390437
Generalised tonic-clonic seizure 28.84 14.35 62 37798 26248 50541016
Osteoarthritis 28.48 14.35 8 37852 68598 50498666
Refusal of treatment by patient 27.92 14.35 26 37834 5027 50562237
Disorganised speech 27.88 14.35 14 37846 977 50566287
Amenorrhoea 27.76 14.35 33 37827 8451 50558813
Psychomotor skills impaired 27.75 14.35 18 37842 2046 50565218
Flushing 27.48 14.35 8 37852 67007 50500257
Leukopenia 26.94 14.35 111 37749 67417 50499847
Flight of ideas 26.91 14.35 10 37850 332 50566932
Leukocytosis 26.84 14.35 55 37805 22524 50544740
Electrocardiogram PR prolongation 26.73 14.35 12 37848 651 50566613
Irritability 26.71 14.35 63 37797 28363 50538901
Screaming 26.13 14.35 20 37840 2958 50564306
False positive investigation result 26.05 14.35 11 37849 514 50566750
Asthenia 25.77 14.35 137 37723 318905 50248359
Bronchitis 25.70 14.35 24 37836 104135 50463129
Dementia 25.27 14.35 44 37816 15953 50551311
Nasal congestion 25.23 14.35 4 37856 51116 50516148
Grandiosity 24.84 14.35 9 37851 278 50566986
Stress 24.83 14.35 5 37855 53788 50513476
Thinking abnormal 24.60 14.35 33 37827 9534 50557730
Parkinsonian gait 24.42 14.35 10 37850 432 50566832
Femoral neck fracture 24.28 14.35 29 37831 7461 50559803
Stomatitis 24.25 14.35 24 37836 101320 50465944
Reduced facial expression 24.17 14.35 15 37845 1579 50565685
Infection 24.13 14.35 59 37801 172895 50394369
Dermatitis exfoliative 23.79 14.35 24 37836 5118 50562146
Intentional product misuse 23.75 14.35 83 37777 46651 50520613
Burning sensation 23.73 14.35 3 37857 45443 50521821
Dyspepsia 23.61 14.35 13 37847 74084 50493180
Haemoglobin urine 23.59 14.35 7 37853 113 50567151
Seizure 23.57 14.35 160 37700 117714 50449550
Fibromyalgia 23.41 14.35 3 37857 44975 50522289
Drug ineffective 23.32 14.35 453 37407 818880 49748384
Duodenal stenosis 23.31 14.35 10 37850 486 50566778
Influenza like illness 23.30 14.35 7 37853 57452 50509812
Hypoaesthesia 23.28 14.35 37 37823 127220 50440044
Dyspnoea exertional 23.16 14.35 5 37855 51228 50516036
Autonomic nervous system imbalance 23.11 14.35 17 37843 2368 50564896
Diabetic coma 23.03 14.35 11 37849 688 50566576
Differential white blood cell count abnormal 23.03 14.35 11 37849 688 50566576
Blunted affect 22.96 14.35 8 37852 220 50567044
Electroconvulsive therapy 22.76 14.35 6 37854 61 50567203
Staring 22.68 14.35 14 37846 1460 50565804
Muscle enzyme increased 22.62 14.35 7 37853 131 50567133
Bone marrow eosinophilic leukocyte count increased 22.58 14.35 5 37855 22 50567242
Hepatic enzyme increased 22.36 14.35 43 37817 137337 50429927
Psychiatric decompensation 22.08 14.35 13 37847 1245 50566019
Electrolyte imbalance 21.81 14.35 43 37817 17126 50550138
Agranulocytosis 21.80 14.35 49 37811 21372 50545892
Myocardial reperfusion injury 21.73 14.35 5 37855 27 50567237
Incorrect route of product administration 21.63 14.35 45 37815 18621 50548643
Allergic hepatitis 21.58 14.35 5 37855 28 50567236
Asthma 21.55 14.35 21 37839 89316 50477948
Self-medication 21.41 14.35 16 37844 2283 50564981
Tongue biting 21.41 14.35 13 37847 1317 50565947
Weight decreased 21.38 14.35 89 37771 221156 50346108
Refusal of examination 21.35 14.35 6 37854 79 50567185
Polydipsia 21.09 14.35 18 37842 3106 50564158
Antipsychotic drug level below therapeutic 21.00 14.35 8 37852 285 50566979
Apallic syndrome 20.98 14.35 10 37850 623 50566641
Lactate pyruvate ratio increased 20.62 14.35 6 37854 90 50567174
Exposure during pregnancy 20.58 14.35 158 37702 120857 50446407
Injection site reaction 20.46 14.35 6 37854 50026 50517238
Protrusion tongue 20.31 14.35 8 37852 312 50566952
Respiratory depression 20.24 14.35 34 37826 11976 50555288
COVID-19 20.21 14.35 5 37855 46657 50520607
Delusion of reference 20.09 14.35 6 37854 99 50567165
Urinary incontinence 19.77 14.35 56 37804 28152 50539112
Acute psychosis 19.67 14.35 15 37845 2205 50565059
Venous thrombosis limb 19.55 14.35 16 37844 2606 50564658
Lipids decreased 19.52 14.35 4 37856 11 50567253
Folliculitis 19.51 14.35 3 37857 39222 50528042
Hyperthermia malignant 19.51 14.35 10 37850 729 50566535
Communication disorder 19.43 14.35 15 37845 2246 50565018
Muscle strength abnormal 19.42 14.35 5 37855 46 50567218
Pressure of speech 19.12 14.35 9 37851 545 50566719
Rash pruritic 19.09 14.35 6 37854 47840 50519424
Diabetes mellitus 19.08 14.35 80 37780 48953 50518311
Euphoric mood 18.90 14.35 19 37841 4036 50563228
Pulmonary vasculitis 18.61 14.35 5 37855 55 50567209
Clonus 18.43 14.35 19 37841 4156 50563108
Blood citric acid increased 18.29 14.35 5 37855 59 50567205
Ill-defined disorder 18.28 14.35 9 37851 54645 50512619
Hepatitis acute 18.28 14.35 26 37834 7935 50559329
Brain oedema 18.22 14.35 33 37827 12337 50554927
Brief psychotic disorder with marked stressors 18.21 14.35 5 37855 60 50567204
Myoclonus 18.09 14.35 36 37824 14434 50552830
Coma scale abnormal 18.04 14.35 20 37840 4751 50562513
Cardio-respiratory arrest 18 14.35 84 37776 53808 50513456
Dry skin 17.99 14.35 5 37855 43186 50524078
Epileptic encephalopathy 17.87 14.35 7 37853 269 50566995
Multiple sclerosis relapse 17.85 14.35 5 37855 42959 50524305
Apathy 17.85 14.35 25 37835 7523 50559741
Cardiomyopathy alcoholic 17.81 14.35 4 37856 19 50567245
Carnitine deficiency 17.61 14.35 6 37854 154 50567110
Hypomania 17.23 14.35 19 37841 4486 50562778
Vulvovaginal candidiasis 17.14 14.35 15 37845 2677 50564587
Lower respiratory tract infection 17.11 14.35 28 37832 95173 50472091
Illusion 17.07 14.35 10 37850 949 50566315
Neutropenia 16.83 14.35 177 37683 147788 50419476
Poor personal hygiene 16.76 14.35 7 37853 318 50566946
Inflammation 16.70 14.35 11 37849 56901 50510363
Anticonvulsant drug level above therapeutic 16.68 14.35 8 37852 505 50566759
Red blood cells urine 16.68 14.35 8 37852 505 50566759
Ureteric obstruction 16.67 14.35 12 37848 1616 50565648
Granulomatous liver disease 16.62 14.35 9 37851 734 50566530
Blood pressure increased 16.60 14.35 48 37812 133084 50434180
Mydriasis 16.48 14.35 29 37831 10598 50556666
Intentional product use issue 16.43 14.35 20 37840 76898 50490366
Encephalopathy 16.38 14.35 59 37801 33652 50533612
Blood glucose 16.26 14.35 4 37856 30 50567234
Electrocardiogram abnormal 16.24 14.35 24 37836 7581 50559683
Somatic hallucination 16.06 14.35 3 37857 4 50567260
Hypokinesia 16.01 14.35 31 37829 12186 50555078
Fluid retention 15.97 14.35 9 37851 50640 50516624
Night sweats 15.75 14.35 3 37857 33571 50533693
Retinitis pigmentosa 15.71 14.35 5 37855 103 50567161
Wheezing 15.65 14.35 14 37846 62033 50505231
Poisoning 15.63 14.35 31 37829 12398 50554866
Aspiration 15.31 14.35 26 37834 9238 50558026
Malaise 15.25 14.35 169 37691 335363 50231901
Circadian rhythm sleep disorder 15.23 14.35 6 37854 234 50567030
Systemic infection 15.10 14.35 13 37847 2270 50564994
Grimacing 15.02 14.35 7 37853 414 50566850
Hyperthyroidism 14.87 14.35 30 37830 12145 50555119
Brain death 14.76 14.35 14 37846 2769 50564495
Antidepressant drug level increased 14.75 14.35 6 37854 255 50567009
Tonic clonic movements 14.73 14.35 10 37850 1227 50566037
Erythema 14.70 14.35 58 37802 146356 50420908
Mental disorder due to a general medical condition 14.69 14.35 5 37855 128 50567136
Tachyphrenia 14.67 14.35 10 37850 1235 50566029
Malignant catatonia 14.61 14.35 5 37855 130 50567134
Tachycardia paroxysmal 14.53 14.35 6 37854 265 50566999
Cellulitis 14.50 14.35 19 37841 70779 50496485
Eosinophil count abnormal 14.45 14.35 7 37853 452 50566812
Trismus 14.36 14.35 15 37845 3333 50563931

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 1804.85 13.05 753 47408 15395 29510971
Extrapyramidal disorder 1629.88 13.05 626 47535 10205 29516161
Dystonia 679.11 13.05 327 47834 9422 29516944
Intentional self-injury 559.06 13.05 311 47850 12150 29514216
Akathisia 508.75 13.05 239 47922 6503 29519863
Muscle rigidity 408.77 13.05 230 47931 9181 29517185
Agitation 372.54 13.05 438 47723 50866 29475500
Parkinsonism 324.56 13.05 181 47980 7097 29519269
Sedation 320.94 13.05 249 47912 17156 29509210
Catatonia 320.51 13.05 153 48008 4315 29522051
Weight increased 315.89 13.05 497 47664 76170 29450196
Psychotic disorder 309.22 13.05 260 47901 20094 29506272
Tardive dyskinesia 305.57 13.05 156 48005 5102 29521264
Delirium 291.94 13.05 340 47821 39057 29487309
Salivary hypersecretion 263.28 13.05 159 48002 7250 29519116
Aggression 252.13 13.05 300 47861 35241 29491125
Blood creatine phosphokinase increased 244.83 13.05 316 47845 40328 29486038
Hyperprolactinaemia 244.21 13.05 88 48073 1182 29525184
Suicide attempt 240.43 13.05 287 47874 33823 29492543
Sopor 238.42 13.05 173 47988 10761 29515605
Delusion 203.54 13.05 159 48002 11057 29515309
Tachycardia 197.60 13.05 392 47769 72018 29454348
Electrocardiogram QT prolonged 197.60 13.05 268 47893 35869 29490497
Somnolence 192.65 13.05 453 47708 93502 29432864
Hallucination, auditory 191.64 13.05 144 48017 9449 29516917
Drug interaction 187.02 13.05 724 47437 196661 29329705
Schizophrenia 180.99 13.05 120 48041 6445 29519921
Dyskinesia 173.93 13.05 188 47973 19873 29506493
Antipsychotic drug level below therapeutic 158.23 13.05 73 48088 1901 29524465
Intentional overdose 150.47 13.05 244 47917 38284 29488082
Hypertonia 145.98 13.05 86 48075 3743 29522623
Disinhibition 144.67 13.05 75 48086 2532 29523834
Emotional poverty 139.21 13.05 45 48116 424 29525942
Diarrhoea 137.77 13.05 206 47955 332492 29193874
Rhabdomyolysis 137.58 13.05 305 47856 60503 29465863
Restlessness 134.53 13.05 173 47988 21972 29504394
Tremor 134.01 13.05 339 47822 73199 29453167
Obsessive-compulsive disorder 131.86 13.05 86 48075 4490 29521876
Fatigue 129.36 13.05 198 47963 316623 29209743
Arthralgia 125.39 13.05 36 48125 139581 29386785
Rash 116.20 13.05 84 48077 189735 29336631
Dyspnoea 116.15 13.05 223 47938 326509 29199857
Therapeutic product effect variable 115.79 13.05 58 48103 1819 29524547
Serotonin syndrome 105.09 13.05 136 48025 17376 29508990
Embolism venous 104.77 13.05 49 48112 1317 29525049
Granulocytopenia 104.47 13.05 83 48078 5911 29520455
Hypothermia 102.64 13.05 99 48062 9140 29517226
Oculogyric crisis 101.86 13.05 48 48113 1313 29525053
Coma 100.83 13.05 208 47953 39242 29487124
Toxicity to various agents 100.74 13.05 552 47609 173109 29353257
Cogwheel rigidity 99.72 13.05 46 48115 1197 29525169
Nausea 97.92 13.05 203 47958 289052 29237314
Euphoric mood 97.62 13.05 73 48088 4752 29521614
Psychomotor hyperactivity 95.02 13.05 90 48071 8123 29518243
Oropharyngeal spasm 93.63 13.05 26 48135 136 29526230
Dizziness 93.21 13.05 103 48058 189581 29336785
Increased appetite 93.13 13.05 78 48083 5986 29520380
Sluggishness 92.70 13.05 59 48102 2952 29523414
Abnormal behaviour 89.61 13.05 146 48015 22981 29503385
Headache 86.02 13.05 94 48067 173913 29352453
Altered state of consciousness 84.55 13.05 131 48030 19758 29506608
Incorrect route of product administration 82.88 13.05 95 48066 10706 29515660
Hyperthermia 82.80 13.05 89 48072 9341 29517025
Treatment noncompliance 80.71 13.05 143 48018 24084 29502282
Pneumonia aspiration 79.36 13.05 181 47980 36556 29489810
Mutism 78.45 13.05 33 48128 684 29525682
Torsade de pointes 77.07 13.05 73 48088 6588 29519778
Dysphagia 76.88 13.05 230 47931 54696 29471670
Drooling 75.56 13.05 52 48109 2969 29523397
Pain in extremity 75.51 13.05 43 48118 110390 29415976
Asthenia 75.35 13.05 148 48013 215102 29311264
Cough 74.98 13.05 58 48103 126669 29399697
Anaemia 73.10 13.05 135 48026 200816 29325550
Cognitive disorder 72.30 13.05 134 48027 23365 29503001
Malignant catatonia 71.99 13.05 23 48138 208 29526158
Confusional state 71.71 13.05 403 47758 127474 29398892
Pain 70.84 13.05 106 48055 171326 29355040
Cardiac failure congestive 68.22 13.05 20 48141 76561 29449805
Depressed level of consciousness 66.88 13.05 170 47991 36772 29489594
Dysarthria 66.43 13.05 152 48009 30759 29495607
Myocardial infarction 64.58 13.05 51 48110 110245 29416121
Psychotic symptom 62.56 13.05 35 48126 1379 29524987
Hallucination 62.33 13.05 187 47974 44525 29481841
Torticollis 62.19 13.05 32 48129 1063 29525303
Myoclonus 61.29 13.05 91 48070 13218 29513148
Spasmodic dysphonia 60.14 13.05 16 48145 69 29526297
Nasopharyngitis 60.14 13.05 12 48149 59653 29466713
Paranoia 59.70 13.05 77 48084 9800 29516566
Protrusion tongue 59.55 13.05 19 48142 171 29526195
Back pain 58.99 13.05 48 48113 102236 29424130
Antipsychotic drug level increased 58.87 13.05 46 48115 3197 29523169
Persecutory delusion 58.67 13.05 39 48122 2102 29524264
Febrile neutropenia 58.37 13.05 58 48103 112182 29414184
Overdose 57.56 13.05 270 47891 79549 29446817
Opisthotonus 56.81 13.05 23 48138 431 29525935
Disorientation 56.76 13.05 139 48022 29376 29496990
Infusion related reaction 55.98 13.05 4 48157 43882 29482484
Death 55.35 13.05 329 47832 341755 29184611
Myocarditis 54.94 13.05 78 48083 10878 29515488
Bradykinesia 54.30 13.05 45 48116 3402 29522964
Schizoaffective disorder 53.74 13.05 29 48132 1063 29525303
Pruritus 53.51 13.05 67 48094 116782 29409584
Product dose omission issue 53.41 13.05 47 48114 96336 29430030
Stupor 52.16 13.05 40 48121 2704 29523662
Intestinal pseudo-obstruction 51.92 13.05 30 48131 1258 29525108
Social avoidant behaviour 51.83 13.05 41 48120 2901 29523465
Mania 51.52 13.05 67 48094 8596 29517770
Neuropathy peripheral 50.94 13.05 26 48135 71001 29455365
Speech disorder 49.81 13.05 115 48046 23401 29502965
Dyslipidaemia 49.37 13.05 55 48106 6006 29520360
Ileus paralytic 48.87 13.05 51 48110 5172 29521194
Mental impairment 48.70 13.05 67 48094 9074 29517292
White blood cell count increased 48.64 13.05 153 48008 37363 29489003
Accidental exposure to product by child 47.93 13.05 29 48132 1325 29525041
Hyperreflexia 47.48 13.05 38 48123 2734 29523632
Pneumonia 46.59 13.05 318 47843 319854 29206512
Prescribed overdose 45.30 13.05 63 48098 8620 29517746
Visceral congestion 44.54 13.05 20 48141 488 29525878
Psychosexual disorder 43.72 13.05 13 48148 90 29526276
Peripheral swelling 43.27 13.05 25 48136 63714 29462652
Interstitial lung disease 43.10 13.05 20 48141 57698 29468668
Leukopenia 42.94 13.05 191 47970 55012 29471354
Blood prolactin abnormal 42.78 13.05 23 48138 837 29525529
Oromandibular dystonia 42.72 13.05 19 48142 453 29525913
Joint swelling 42.32 13.05 14 48147 49616 29476750
Priapism 42.31 13.05 44 48117 4444 29521922
Water intoxication 42.01 13.05 18 48143 391 29525975
Delusion of grandeur 41.27 13.05 18 48143 409 29525957
Encephalitis toxic 41.00 13.05 16 48145 271 29526095
Choking 40.50 13.05 43 48118 4448 29521918
Cerebrovascular accident 39.67 13.05 40 48121 76871 29449495
Urticaria 39.20 13.05 20 48141 54640 29471726
Disturbance in attention 39.19 13.05 99 48062 21325 29505041
Psychomotor retardation 39.06 13.05 35 48126 2941 29523425
Atrial fibrillation 38.31 13.05 71 48090 105575 29420791
Erythema 38.22 13.05 40 48121 75566 29450800
Psoriasis 38.21 13.05 4 48157 32223 29494143
Eye movement disorder 38.05 13.05 38 48123 3658 29522708
Chest discomfort 37.44 13.05 14 48147 45969 29480397
Blood prolactin increased 37.41 13.05 26 48135 1508 29524858
Bradyphrenia 37.39 13.05 40 48121 4174 29522192
Autonomic nervous system imbalance 37.39 13.05 31 48130 2345 29524021
Self-injurious ideation 37.15 13.05 26 48135 1525 29524841
Peptostreptococcus infection 36.62 13.05 9 48152 26 29526340
Abdominal pain upper 35.92 13.05 28 48133 60965 29465401
Refusal of treatment by patient 35.52 13.05 41 48120 4653 29521713
Pyramidal tract syndrome 35.38 13.05 13 48148 185 29526181
Trismus 35.35 13.05 30 48131 2343 29524023
Mental disorder 35.27 13.05 70 48091 12835 29513531
Obesity 35.16 13.05 60 48101 9803 29516563
Sinusitis 34.41 13.05 7 48154 34343 29492023
Waxy flexibility 34.28 13.05 11 48150 101 29526265
Epistaxis 34.08 13.05 21 48140 51683 29474683
Product packaging issue 34.02 13.05 17 48144 530 29525836
Huntington's disease 33.98 13.05 9 48152 38 29526328
Chest pain 33.34 13.05 84 48077 111889 29414477
Oral discharge 32.59 13.05 11 48150 120 29526246
Herpes zoster 32.55 13.05 5 48156 30047 29496319
Sinus tachycardia 32.25 13.05 74 48087 14995 29511371
Influenza 32.06 13.05 14 48147 41867 29484499
Coronary artery disease 31.94 13.05 16 48145 44174 29482192
Medication error 31.73 13.05 91 48070 21120 29505246
Asthma 31.70 13.05 8 48153 33841 29492525
Decreased appetite 31.38 13.05 126 48035 145216 29381150
Sudden death 30.98 13.05 70 48091 14040 29512326
Body temperature increased 30.91 13.05 71 48090 14394 29511972
Arthritis 29.93 13.05 3 48158 25016 29501350
Intentional product use issue 29.80 13.05 16 48145 42482 29483884
Injection site pain 29.76 13.05 8 48153 32438 29493928
Hypoaesthesia 29.68 13.05 26 48135 53441 29472925
Compulsive sexual behaviour 29.58 13.05 12 48149 226 29526140
Epilepsy 29.45 13.05 81 48080 18351 29508015
Angina pectoris 29.34 13.05 5 48156 27845 29498521
Withdrawal syndrome 29.29 13.05 59 48102 10933 29515433
Urinary retention 29.18 13.05 116 48045 31782 29494584
Tic 28.99 13.05 24 48137 1811 29524555
Tachypnoea 28.85 13.05 71 48090 15044 29511322
Haemorrhage 28.75 13.05 19 48142 45053 29481313
Psychiatric decompensation 28.75 13.05 22 48139 1482 29524884
Anticholinergic syndrome 28.73 13.05 18 48143 876 29525490
Colitis ischaemic 28.52 13.05 41 48120 5782 29520584
Rapid eye movement sleep behaviour disorder 28.47 13.05 10 48151 124 29526242
Gastrointestinal haemorrhage 28.34 13.05 54 48107 79479 29446887
Patient restraint 27.73 13.05 9 48152 86 29526280
Bruxism 27.70 13.05 22 48139 1565 29524801
Posturing 27.10 13.05 14 48147 469 29525897
Resting tremor 26.56 13.05 15 48146 602 29525764
HIV peripheral neuropathy 26.54 13.05 7 48154 29 29526337
Blunted affect 26.45 13.05 12 48149 300 29526066
Leukocytosis 26.28 13.05 85 48076 21057 29505309
Oedema peripheral 26.17 13.05 84 48077 103473 29422893
Abdominal discomfort 25.75 13.05 24 48137 47879 29478487
Coma scale abnormal 25.75 13.05 30 48131 3439 29522927
Paraesthesia 25.54 13.05 30 48131 53815 29472551
Acute myocardial infarction 25.18 13.05 25 48136 48413 29477953
Mental status changes 25.03 13.05 118 48043 34809 29491557
Musculoskeletal pain 24.97 13.05 8 48153 28945 29497421
Rebound effect 24.92 13.05 23 48138 2008 29524358
Cytomegalovirus infection 24.83 13.05 4 48157 23211 29503155
Irritability 24.82 13.05 86 48075 22066 29504300
Generalised tonic-clonic seizure 24.74 13.05 78 48083 19061 29507305
Reduced facial expression 24.68 13.05 15 48146 691 29525675
Stomatitis 24.56 13.05 15 48146 37098 29489268
Exhibitionism 24.54 13.05 7 48154 41 29526325
Weight decreased 24.35 13.05 145 48016 150760 29375606
Acute kidney injury 24.28 13.05 296 47865 264971 29261395
Muscle contractions involuntary 24.04 13.05 21 48140 1706 29524660
Aspiration 24.04 13.05 52 48109 10128 29516238
Foetal alcohol syndrome 24.00 13.05 9 48152 136 29526230
Completed suicide 23.79 13.05 238 47923 90008 29436358
Galactorrhoea 23.79 13.05 12 48149 382 29525984
Agranulocytosis 23.69 13.05 80 48081 20260 29506106
Diet refusal 23.57 13.05 11 48150 294 29526072
Leukaemia 23.49 13.05 30 48131 3780 29522586
Intentional product misuse 23.32 13.05 115 48046 34546 29491820
Haematochezia 23.04 13.05 16 48145 36967 29489399
Antipsychotic drug level above therapeutic 23.03 13.05 17 48144 1084 29525282
Postoperative respiratory failure 23.01 13.05 8 48153 96 29526270
Sexual dysfunction 22.91 13.05 37 48124 5777 29520589
Drug level increased 22.87 13.05 75 48086 18712 29507654
Neutrophil count increased 22.78 13.05 64 48097 14678 29511688
Pancytopenia 22.77 13.05 65 48096 83103 29443263
Thrombosis 22.63 13.05 22 48139 43023 29483343
Ascites 22.60 13.05 16 48145 36603 29489763
Apathy 22.60 13.05 38 48123 6133 29520233
Suicidal ideation 22.52 13.05 114 48047 34602 29491764
Chorea 22.47 13.05 16 48145 965 29525401
Muscle contracture 22.34 13.05 17 48144 1136 29525230
Vascular stenosis 22.02 13.05 9 48152 173 29526193
Dextrocardia 21.83 13.05 8 48153 113 29526253
Disease progression 21.71 13.05 65 48096 81851 29444515
Hyponatraemia 21.66 13.05 186 47975 67447 29458919
Hyperkalaemia 21.59 13.05 42 48119 61350 29465016
Drug withdrawal syndrome neonatal 21.35 13.05 27 48134 3368 29522998
Cardiac arrest 21.26 13.05 223 47938 85368 29440998
Urinary incontinence 21.15 13.05 67 48094 16414 29509952
Unresponsive to stimuli 21.10 13.05 89 48072 25037 29501329
Accidental exposure to product 21.04 13.05 51 48110 10702 29515664
Physical assault 21.04 13.05 16 48145 1068 29525298
Type 2 diabetes mellitus 21.02 13.05 59 48102 13522 29512844
Snoring 20.53 13.05 24 48137 2760 29523606
Skin lesion 20.32 13.05 3 48158 18569 29507797
Thinking abnormal 20.19 13.05 33 48128 5203 29521163
Colitis 20.16 13.05 13 48148 31235 29495131
Inappropriate affect 20.14 13.05 12 48149 533 29525833
Affective disorder 19.88 13.05 25 48136 3101 29523265
Drop attacks 19.86 13.05 12 48149 547 29525819
Sexual abuse 19.85 13.05 8 48153 148 29526218
Unevaluable event 19.84 13.05 12 48149 29839 29496527
Hallucinations, mixed 19.68 13.05 22 48139 2411 29523955
Fluid retention 19.47 13.05 7 48154 23553 29502813
Myalgia 19.43 13.05 59 48102 73960 29452406
Flight of ideas 19.22 13.05 10 48151 340 29526026
Parkinsonian gait 19.13 13.05 11 48150 457 29525909
Antidepressant drug level increased 19.09 13.05 7 48154 99 29526267
Pneumonitis 19.02 13.05 11 48150 28033 29498333
Cross sensitivity reaction 18.89 13.05 16 48145 1246 29525120
Hyperhidrosis 18.87 13.05 174 47987 64366 29462000
Cardio-respiratory arrest 18.82 13.05 144 48017 50457 29475909
Haemoglobin decreased 18.62 13.05 102 48059 108273 29418093
Perseveration 18.60 13.05 7 48154 107 29526259
Nasal congestion 18.59 13.05 4 48157 18875 29507491
Renal impairment 18.50 13.05 69 48092 81264 29445102
Gaze palsy 18.49 13.05 16 48145 1283 29525083
Tension 18.47 13.05 19 48142 1894 29524472
Echolalia 18.39 13.05 9 48152 268 29526098
Musculoskeletal stiffness 18.32 13.05 114 48047 37344 29489022
Multiple organ dysfunction syndrome 18.27 13.05 48 48113 63068 29463298
Hypersexuality 17.90 13.05 16 48145 1340 29525026
Dyspnoea exertional 17.66 13.05 20 48141 36470 29489896
Floppy iris syndrome 17.52 13.05 9 48152 298 29526068
Seizure 17.51 13.05 230 47931 92893 29433473
Antisocial behaviour 17.46 13.05 9 48152 300 29526066
Inappropriate antidiuretic hormone secretion 17.42 13.05 48 48113 10884 29515482
Wrong patient received product 17.38 13.05 20 48141 2262 29524104
Malignant neoplasm progression 17.23 13.05 62 48099 73797 29452569
Myelodysplastic syndrome 17.06 13.05 4 48157 17790 29508576
Labile blood pressure 16.86 13.05 11 48150 574 29525792
Judgement impaired 16.75 13.05 11 48150 581 29525785
Dysgeusia 16.70 13.05 8 48153 22666 29503700
Schizoaffective disorder bipolar type 16.65 13.05 5 48156 36 29526330
Syncope 16.63 13.05 72 48089 81299 29445067
Mumps 16.62 13.05 6 48155 81 29526285
Mydriasis 16.62 13.05 33 48128 6052 29520314
Posture abnormal 16.43 13.05 18 48143 1929 29524437
Blood pressure fluctuation 16.29 13.05 6 48155 19888 29506478
Hypersensitivity 16.27 13.05 39 48122 52864 29473502
Primary familial brain calcification 16.27 13.05 3 48158 0 29526366
Speech sound disorder 16.26 13.05 7 48154 154 29526212
Malaise 16.16 13.05 174 47987 159428 29366938
Electrocardiogram J wave 16.16 13.05 4 48157 12 29526354
Hypokinesia 16.05 13.05 37 48124 7517 29518849
Gastrointestinal disorder 15.88 13.05 14 48147 28692 29497674
Negativism 15.83 13.05 9 48152 366 29526000
Hyperammonaemia 15.81 13.05 31 48130 5632 29520734
Haematuria 15.68 13.05 30 48131 44109 29482257
Foetal arrhythmia 15.58 13.05 6 48155 98 29526268
Gender dysphoria 15.57 13.05 5 48156 46 29526320
Cyanosis 15.57 13.05 47 48114 11220 29515146
Cerebrovascular stenosis 15.46 13.05 6 48155 100 29526266
Delusional disorder, unspecified type 15.41 13.05 11 48150 666 29525700
Dysphoria 15.37 13.05 18 48143 2074 29524292
Anxiety 15.29 13.05 209 47952 85156 29441210
Hyperventilation 15.20 13.05 19 48142 2343 29524023
Hallucination, olfactory 15.11 13.05 7 48154 184 29526182
Night sweats 15.04 13.05 3 48158 14929 29511437
Visual acuity reduced 14.96 13.05 3 48158 14873 29511493
Tongue disorder 14.96 13.05 27 48134 4609 29521757
Swollen tongue 14.95 13.05 49 48112 12217 29514149
Acute psychosis 14.94 13.05 16 48145 1671 29524695
Differential white blood cell count abnormal 14.85 13.05 14 48147 1255 29525111
Rabbit syndrome 14.72 13.05 4 48157 19 29526347
Cholelithiasis 14.68 13.05 6 48155 18666 29507700
Dry skin 14.63 13.05 10 48151 23297 29503069
Dementia 14.60 13.05 47 48114 11611 29514755
Condition aggravated 14.56 13.05 326 47835 145969 29380397
Full blood count decreased 14.55 13.05 4 48157 15988 29510378
Gastrooesophageal reflux disease 14.45 13.05 18 48143 31478 29494888
Nephrolithiasis 14.45 13.05 12 48149 25322 29501044
Adactyly 14.23 13.05 5 48156 62 29526304
Exposure to extreme temperature 14.19 13.05 3 48158 3 29526363
Syndactyly 14.08 13.05 11 48150 764 29525602
Blood pressure increased 14.06 13.05 67 48094 73736 29452630
Bronchitis 14.05 13.05 24 48137 36844 29489522
Diabetic coma 14.02 13.05 11 48150 769 29525597
Gout 14.01 13.05 5 48156 16906 29509460
Abdominal distension 13.99 13.05 34 48127 45877 29480489
Impaired self-care 13.95 13.05 12 48149 955 29525411
Osteoarthritis 13.93 13.05 6 48155 18097 29508269
Flushing 13.91 13.05 16 48145 28976 29497390
Cardiomyopathy 13.70 13.05 54 48107 14733 29511633
Coprolalia 13.67 13.05 4 48157 26 29526340
Blood triglycerides increased 13.66 13.05 49 48112 12785 29513581
Polydipsia 13.58 13.05 22 48139 3443 29522923
Mucosal inflammation 13.53 13.05 19 48142 31576 29494790
Haemoptysis 13.46 13.05 18 48143 30532 29495834
Localised infection 13.46 13.05 3 48158 13813 29512553
Incoherent 13.42 13.05 24 48137 4068 29522298
Neuroleptic-induced deficit syndrome 13.42 13.05 4 48157 28 29526338
Pleural effusion 13.28 13.05 66 48095 71842 29454524
Fungal infection 13.27 13.05 3 48158 13682 29512684
Paraphilia 13.25 13.05 5 48156 77 29526289
Pleurothotonus 13.21 13.05 12 48149 1026 29525340
Impaired healing 13.09 13.05 3 48158 13555 29512811
Rebound psychosis 13.08 13.05 6 48155 154 29526212
Pulmonary hypertension 13.05 13.05 7 48154 18601 29507765

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 3097.58 13.42 1138 72224 23858 64401512
Extrapyramidal disorder 2720.58 13.42 970 72392 18582 64406788
Intentional self-injury 1286.51 13.42 638 72724 28406 64396964
Dystonia 936.05 13.42 448 72914 18417 64406953
Catatonia 719.68 13.42 285 73077 7335 64418035
Akathisia 713.37 13.42 319 73043 11191 64414179
Muscle rigidity 712.19 13.42 363 72999 17110 64408260
Agitation 628.77 13.42 630 72732 87737 64337633
Drug interaction 550.02 13.42 1246 72116 360837 64064533
Sopor 529.14 13.42 361 73001 29300 64396070
Parkinsonism 501.15 13.42 269 73093 14104 64411266
Psychotic disorder 494.95 13.42 368 72994 34210 64391160
Delirium 485.94 13.42 490 72872 68704 64356666
Hyperprolactinaemia 472.99 13.42 177 73185 3888 64421482
Salivary hypersecretion 457.09 13.42 239 73123 11874 64413496
Sedation 431.82 13.42 366 72996 41096 64384274
Delusion 429.13 13.42 263 73099 17751 64407619
Tardive dyskinesia 419.06 13.42 206 73156 8972 64416398
Aggression 416.95 13.42 376 72986 45856 64379514
Weight increased 403.95 13.42 804 72558 212544 64212826
Hallucination, auditory 359.90 13.42 230 73132 16709 64408661
Somnolence 351.75 13.42 739 72623 202906 64222464
Blood creatine phosphokinase increased 333.40 13.42 371 72991 58187 64367183
Electrocardiogram QT prolonged 321.03 13.42 423 72939 79025 64346345
Arthralgia 308.40 13.42 64 73298 442196 63983174
Intentional overdose 304.97 13.42 440 72922 89504 64335866
Suicide attempt 283.67 13.42 376 72986 70631 64354739
Psychomotor hyperactivity 279.49 13.42 185 73177 14266 64411104
Schizophrenia 270.94 13.42 165 73197 11003 64414367
Dyskinesia 267.35 13.42 274 73088 39114 64386256
Tremor 247.68 13.42 531 72831 147699 64277671
Fatigue 247.07 13.42 294 73068 748436 63676934
Tachycardia 246.69 13.42 533 72829 149046 64276324
Pain 239.77 13.42 169 73193 553342 63872028
Hypertonia 239.17 13.42 125 73237 6200 64419170
Rhabdomyolysis 238.46 13.42 397 72965 91329 64334041
Restlessness 234.92 13.42 257 73105 39528 64385842
Hypothermia 224.73 13.42 184 73178 19672 64405698
Headache 223.62 13.42 166 73196 529301 63896069
Sluggishness 205.71 13.42 109 73253 5561 64419809
Coma 201.21 13.42 359 73003 87256 64338114
Abnormal behaviour 189.53 13.42 212 73150 33410 64391960
Rash 188.10 13.42 148 73214 458401 63966969
Embolism venous 185.20 13.42 87 73275 3420 64421950
Cogwheel rigidity 182.89 13.42 81 73281 2772 64422598
Oculogyric crisis 178.77 13.42 77 73285 2461 64422909
Joint swelling 172.73 13.42 21 73341 215361 64210009
Bradykinesia 169.66 13.42 101 73261 6459 64418911
Confusional state 168.11 13.42 664 72698 260480 64164890
Pain in extremity 166.88 13.42 68 73294 303017 64122353
Hallucination 166.78 13.42 298 73064 72490 64352880
Rheumatoid arthritis 163.99 13.42 5 73357 164289 64261081
Nausea 162.75 13.42 414 72948 785386 63639984
Granulocytopenia 160.33 13.42 116 73246 10324 64415046
Torsade de pointes 159.96 13.42 143 73219 17220 64408150
Altered state of consciousness 159.50 13.42 206 73156 37696 64387674
Mutism 157.50 13.42 66 73296 1968 64423402
Toxicity to various agents 156.08 13.42 820 72542 362693 64062677
Dyspnoea 155.52 13.42 370 72992 718304 63707066
Infusion related reaction 154.07 13.42 8 73354 164459 64260911
Diarrhoea 150.94 13.42 379 72983 722325 63703045
Dysarthria 150.15 13.42 254 73108 59152 64366218
Pneumonia aspiration 143.98 13.42 249 73113 59022 64366348
Depressed level of consciousness 141.96 13.42 297 73065 81139 64344231
Torticollis 140.17 13.42 62 73300 2115 64423255
Nasopharyngitis 139.27 13.42 27 73335 196046 64229324
Overdose 136.97 13.42 446 72916 159120 64266250
Serotonin syndrome 135.69 13.42 194 73168 39088 64386282
Pruritus 135.47 13.42 95 73267 312305 64113065
Dysphagia 134.83 13.42 343 73019 106469 64318901
Hyperthermia 133.30 13.42 123 73239 15427 64409943
Paranoia 129.92 13.42 124 73238 16228 64409142
Alopecia 128.38 13.42 18 73344 165672 64259698
Peripheral swelling 125.07 13.42 41 73321 209112 64216258
Emotional poverty 124.84 13.42 42 73320 667 64424703
Treatment noncompliance 122.12 13.42 195 73167 43287 64382083
Drooling 117.38 13.42 74 73288 5245 64420125
Psychotic symptom 115.87 13.42 54 73308 2084 64423286
Cough 113.37 13.42 106 73256 302042 64123328
Persecutory delusion 112.72 13.42 66 73296 4092 64421278
Sinusitis 112.71 13.42 16 73346 145912 64279458
Cognitive disorder 109.22 13.42 212 73150 54875 64370495
Mania 108.12 13.42 112 73250 16174 64409196
Psychomotor retardation 107.15 13.42 69 73293 5074 64420296
Stupor 106.48 13.42 73 73289 5962 64419408
Disorientation 104.82 13.42 210 73152 55618 64369752
Dizziness 104.76 13.42 207 73155 429956 63995414
Ileus paralytic 103.74 13.42 82 73280 8333 64417037
Abdominal discomfort 100.11 13.42 41 73321 182281 64243089
Schizoaffective disorder 98.34 13.42 44 73318 1543 64423827
Malignant catatonia 97.87 13.42 30 73332 347 64425023
Galactorrhoea 97.70 13.42 55 73307 3164 64422206
Back pain 97.12 13.42 85 73277 250086 64175284
Swelling 96.48 13.42 31 73331 160187 64265183
Bradyphrenia 93.70 13.42 81 73281 9325 64416045
Accidental exposure to product by child 93.63 13.42 49 73313 2436 64422934
Suicidal ideation 92.72 13.42 222 73140 66320 64359050
Arthropathy 91.70 13.42 14 73348 120953 64304417
Social avoidant behaviour 87.27 13.42 58 73304 4499 64420871
Injection site pain 86.52 13.42 12 73350 111396 64313974
Oropharyngeal spasm 86.04 13.42 25 73337 237 64425133
Blood prolactin increased 82.69 13.42 51 73311 3477 64421893
Hyperreflexia 82.46 13.42 67 73295 7081 64418289
Hypersensitivity 82.14 13.42 62 73300 196390 64228980
Product dose omission issue 82.02 13.42 61 73301 194686 64230684
Urticaria 81.07 13.42 33 73329 147284 64278086
Opisthotonus 80.91 13.42 30 73332 641 64424729
Drug level increased 80.85 13.42 142 73220 34054 64391316
Asthenia 78.95 13.42 238 73124 427806 63997564
Myocarditis 77.01 13.42 96 73266 16947 64408423
Arthritis 75.65 13.42 5 73357 83809 64341561
Mental impairment 75.36 13.42 93 73269 16250 64409120
Oromandibular dystonia 75.33 13.42 31 73331 882 64424488
Urinary retention 74.94 13.42 170 73192 49031 64376339
Antipsychotic drug level increased 74.39 13.42 55 73307 5060 64420310
Speech disorder 73.37 13.42 167 73195 48274 64377096
White blood cell count increased 73.10 13.42 202 73160 65812 64359558
Drug intolerance 72.78 13.42 64 73298 187928 64237442
Abdominal pain upper 72.19 13.42 56 73306 174974 64250396
Negativism 70.25 13.42 28 73334 732 64424638
Myoclonus 69.63 13.42 112 73250 25006 64400364
Drug abuse 68.28 13.42 315 73047 132059 64293311
Mental disorder 68.02 13.42 114 73248 26331 64399039
Chest discomfort 67.22 13.42 24 73338 116082 64309288
Contraindicated product administered 66.45 13.42 20 73342 107809 64317561
Disturbance in attention 66.01 13.42 145 73217 40929 64384441
Autonomic nervous system imbalance 65.94 13.42 47 73315 4085 64421285
Psoriasis 65.54 13.42 4 73358 71699 64353671
Encephalitis autoimmune 64.91 13.42 35 73327 1849 64423521
Incorrect route of product administration 64.74 13.42 104 73258 23194 64402176
Mental status changes 64.62 13.42 184 73178 60978 64364392
Anaemia 64.58 13.42 218 73144 378462 64046908
Cardiac failure congestive 64.48 13.42 34 73328 130546 64294824
Waxy flexibility 64.20 13.42 20 73342 245 64425125
Protrusion tongue 63.95 13.42 22 73340 375 64424995
Cardiac arrest 63.46 13.42 344 73018 153720 64271650
Antipsychotic drug level below therapeutic 63.25 13.42 28 73334 957 64424413
Spasmodic dysphonia 62.88 13.42 18 73344 161 64425209
Herpes zoster 62.75 13.42 8 73354 79179 64346191
Echolalia 61.70 13.42 21 73341 346 64425024
Pleurothotonus 60.98 13.42 36 73326 2266 64423104
Hyponatraemia 60.95 13.42 331 73031 148008 64277362
Sudden death 60.40 13.42 93 73269 20003 64405367
Leukocytosis 59.26 13.42 132 73230 37608 64387762
Intestinal pseudo-obstruction 57.54 13.42 33 73329 1967 64423403
Influenza 56.78 13.42 25 73337 106506 64318864
Asthma 56.29 13.42 19 73343 95206 64330164
Priapism 56.19 13.42 42 73320 3928 64421442
Musculoskeletal pain 56.01 13.42 12 73350 81282 64344088
Wound 55.40 13.42 10 73352 76467 64348903
Chest pain 55.25 13.42 116 73246 235864 64189506
Visceral congestion 54.83 13.42 24 73338 798 64424572
Injection site erythema 54.09 13.42 8 73354 70792 64354578
Unresponsive to stimuli 51.68 13.42 150 73212 50243 64375127
Stereotypy 51.07 13.42 23 73339 819 64424551
Intentional product misuse 50.60 13.42 189 73173 72106 64353264
Hypoaesthesia 49.56 13.42 51 73311 139057 64286313
Miosis 49.49 13.42 68 73294 13198 64412172
Electrocardiogram J wave 49.33 13.42 12 73350 52 64425318
Disinhibition 48.98 13.42 31 73331 2212 64423158
Osteoarthritis 48.75 13.42 7 73355 63329 64362041
Irritability 48.40 13.42 120 73242 36626 64388744
Paraesthesia 48.29 13.42 49 73313 134473 64290897
Hallucinations, mixed 48.27 13.42 46 73316 6006 64419364
Delusion of grandeur 48.24 13.42 20 73342 580 64424790
Impaired healing 48.18 13.42 6 73356 60467 64364903
Hypernatraemia 47.78 13.42 64 73298 12125 64413245
Product packaging issue 47.74 13.42 23 73339 957 64424413
Refusal of treatment by patient 47.69 13.42 53 73309 8286 64417084
Leukopenia 47.17 13.42 234 73128 101008 64324362
Neutrophil count increased 46.40 13.42 94 73268 25080 64400290
Weight decreased 46.31 13.42 168 73194 285571 64139799
Erythema 46.31 13.42 89 73273 186981 64238389
Stomatitis 45.26 13.42 35 73327 109570 64315800
Malaise 45.20 13.42 265 73097 395982 64029388
Generalised tonic-clonic seizure 45.15 13.42 123 73239 39734 64385636
Obsessive-compulsive disorder 45.00 13.42 40 73322 4778 64420592
Nasal congestion 44.98 13.42 7 73355 59651 64365719
Epistaxis 44.94 13.42 28 73334 98103 64327267
Lethargy 44.48 13.42 182 73180 72412 64352958
Myalgia 44.22 13.42 70 73292 158547 64266823
Self-injurious ideation 43.43 13.42 33 73329 3164 64422206
Interstitial lung disease 43.24 13.42 29 73333 97703 64327667
Reduced facial expression 43.16 13.42 28 73334 2085 64423285
Discomfort 43.06 13.42 19 73343 80859 64344511
Encephalitis toxic 42.54 13.42 15 73347 276 64425094
Bronchitis 42.09 13.42 37 73325 108706 64316664
Inappropriate antidiuretic hormone secretion 42.00 13.42 84 73278 22205 64403165
Gestational diabetes 41.78 13.42 41 73321 5549 64419821
Psychiatric decompensation 41.58 13.42 29 73333 2434 64422936
Thinking abnormal 41.26 13.42 58 73304 11498 64413872
Hyperammonaemic encephalopathy 40.53 13.42 35 73327 4023 64421347
Coma scale abnormal 40.37 13.42 47 73315 7727 64417643
Blunted affect 40.37 13.42 16 73346 412 64424958
Myocardial infarction 40.08 13.42 80 73282 165741 64259629
Euphoric mood 39.62 13.42 43 73319 6548 64418822
Tachypnoea 39.56 13.42 91 73271 26480 64398890
Parotitis 39.45 13.42 27 73335 2198 64423172
Choking 39.28 13.42 54 73308 10484 64414886
Bradycardia 38.98 13.42 249 73113 117970 64307400
Huntington's disease 38.93 13.42 8 73354 12 64425358
Fluid retention 38.68 13.42 10 73352 59596 64365774
Trismus 38.61 13.42 37 73325 4864 64420506
Parkinsonian gait 38.58 13.42 19 73343 830 64424540
Febrile neutropenia 38.48 13.42 99 73263 187558 64237812
Akinesia 37.94 13.42 30 73332 3049 64422321
Psychosexual disorder 37.15 13.42 11 73351 112 64425258
Eye movement disorder 37.10 13.42 43 73319 7036 64418334
Contusion 37.07 13.42 45 73317 113920 64311450
Nuchal rigidity 36.46 13.42 19 73343 936 64424434
Colitis ischaemic 36.07 13.42 59 73303 13355 64412015
Diet refusal 35.95 13.42 18 73344 815 64424555
Accidental exposure to product 35.68 13.42 87 73275 26277 64399093
Flight of ideas 35.59 13.42 17 73345 694 64424676
Blood pressure increased 35.40 13.42 91 73271 172461 64252909
Dementia 35.29 13.42 75 73287 20691 64404679
Flushing 35.25 13.42 23 73339 78625 64346745
Prescribed overdose 35.22 13.42 74 73288 20257 64405113
Oedema peripheral 35.16 13.42 122 73240 210195 64215175
Impulsive behaviour 35.10 13.42 27 73335 2636 64422734
Seizure 34.98 13.42 316 73046 166576 64258794
Chorea 34.83 13.42 24 73338 1976 64423394
Agranulocytosis 34.68 13.42 109 73253 38120 64387250
Pulmonary embolism 34.27 13.42 284 73078 146072 64279298
Distractibility 34.03 13.42 16 73346 630 64424740
Hypersexuality 33.70 13.42 21 73341 1458 64423912
Hallucination, visual 33.65 13.42 88 73274 27746 64397624
Sexual dysfunction 33.40 13.42 39 73323 6432 64418938
Feeling guilty 33.23 13.42 17 73345 806 64424564
Compulsive sexual behaviour 33.20 13.42 12 73350 238 64425132
Peptostreptococcus infection 33.13 13.42 9 73353 65 64425305
Burning sensation 32.87 13.42 8 73354 49656 64375714
Intentional product use issue 32.80 13.42 36 73326 95328 64330042
Oral discharge 32.74 13.42 12 73350 248 64425122
Helicobacter infection 32.61 13.42 3 73359 38359 64387011
Gastrooesophageal reflux disease 32.52 13.42 28 73334 83115 64342255
Illogical thinking 32.44 13.42 9 73353 71 64425299
Aspiration 32.26 13.42 64 73298 16821 64408549
Differential white blood cell count abnormal 32.18 13.42 22 73340 1788 64423582
Injection site reaction 31.91 13.42 7 73355 46657 64378713
Cerebrovascular accident 31.87 13.42 68 73294 137515 64287855
Bruxism 31.70 13.42 29 73333 3595 64421775
Sinus tachycardia 31.27 13.42 94 73268 32094 64393276
Muscle contractions involuntary 30.63 13.42 27 73335 3190 64422180
Multiple sclerosis relapse 30.62 13.42 5 73357 41130 64384240
Haematochezia 30.30 13.42 19 73343 66354 64359016
Pyramidal tract syndrome 30.19 13.42 14 73348 534 64424836
Withdrawal syndrome 30.18 13.42 76 73286 23416 64401954
Somatic symptom disorder of pregnancy 30.11 13.42 9 73353 95 64425275
Hyperhidrosis 30.10 13.42 244 73118 124676 64300694
Patient restraint 30.02 13.42 9 73353 96 64425274
Posturing 29.93 13.42 17 73345 995 64424375
Neuropathy peripheral 29.87 13.42 55 73307 117470 64307900
Epilepsy 29.86 13.42 95 73267 33436 64391934
Dyspnoea exertional 29.86 13.42 24 73338 73706 64351664
Grandiosity 29.78 13.42 14 73348 551 64424819
Dementia with Lewy bodies 29.70 13.42 15 73347 692 64424678
Apathy 29.66 13.42 49 73313 11183 64414187
Resting tremor 29.53 13.42 19 73343 1395 64423975
Floppy iris syndrome 29.44 13.42 12 73350 333 64425037
Inflammation 29.39 13.42 19 73343 65281 64360089
Therapeutic product effect decreased 29.30 13.42 54 73308 115297 64310073
Cardio-respiratory arrest 29.26 13.42 202 73160 98191 64327179
Tic 29.06 13.42 24 73338 2595 64422775
Decreased appetite 29.00 13.42 194 73168 281095 64144275
Negative symptoms in schizophrenia 28.84 13.42 9 73353 111 64425259
Drug hypersensitivity 28.72 13.42 156 73206 237659 64187711
Injection site swelling 28.69 13.42 6 73356 41347 64384023
Antidepressant drug level increased 28.63 13.42 12 73350 358 64425012
Sinus bradycardia 28.31 13.42 73 73289 22820 64402550
Pain in jaw 28.10 13.42 6 73356 40749 64384621
Dyspepsia 27.97 13.42 30 73332 80282 64345088
HIV peripheral neuropathy 27.96 13.42 7 73355 35 64425335
Oropharyngeal pain 27.94 13.42 36 73326 88831 64336539
Electroencephalogram abnormal 27.93 13.42 32 73330 5171 64420199
Gastrointestinal haemorrhage 27.73 13.42 69 73293 132243 64293127
Infection 27.17 13.42 113 73249 184767 64240603
Acute psychosis 27.08 13.42 27 73335 3725 64421645
Toxic epidermal necrolysis 26.69 13.42 98 73264 37068 64388302
Behaviour disorder 26.62 13.42 29 73333 4433 64420937
Tension 26.55 13.42 27 73335 3813 64421557
Urinary incontinence 26.54 13.42 96 73266 36055 64389315
Psychomotor skills impaired 26.53 13.42 27 73335 3818 64421552
Delusional disorder, unspecified type 26.33 13.42 14 73348 719 64424651
Circadian rhythm sleep disorder 26.16 13.42 13 73349 579 64424791
Water intoxication 26.03 13.42 14 73348 736 64424634
Hypokinesia 25.99 13.42 58 73304 16538 64408832
Sexually inappropriate behaviour 25.92 13.42 12 73350 456 64424914
Medication error 25.80 13.42 119 73243 49847 64375523
Dry skin 25.72 13.42 13 73349 51148 64374222
Ill-defined disorder 25.67 13.42 9 73353 44043 64381327
Cardiomyopathy alcoholic 25.60 13.42 7 73355 52 64425318
Palpitations 25.59 13.42 50 73312 104438 64320932
Eye pain 25.53 13.42 3 73359 31622 64393748
Communication disorder 25.52 13.42 26 73336 3680 64421690
Night sweats 25.49 13.42 5 73357 36041 64389329
Respiratory failure 25.49 13.42 288 73074 160895 64264475
Hyporesponsive to stimuli 25.41 13.42 19 73343 1778 64423592
Illusion 25.38 13.42 18 73344 1552 64423818
Speech sound disorder 25.37 13.42 7 73355 54 64425316
Treatment failure 25.20 13.42 60 73302 116756 64308614
Blood pressure fluctuation 24.87 13.42 14 73348 51857 64373513
Pressure of speech 24.81 13.42 15 73347 986 64424384
Psychiatric symptom 24.68 13.42 33 73329 6240 64419130
Drop attacks 24.62 13.42 15 73347 1000 64424370
Muscle contracture 24.52 13.42 20 73342 2125 64423245
Staring 24.50 13.42 21 73341 2389 64422981
Eosinophilic myocarditis 24.36 13.42 14 73348 838 64424532
Blood prolactin abnormal 24.17 13.42 22 73340 2710 64422660
Diverticulitis 24.08 13.42 7 73355 38611 64386759
Haemorrhage 24.08 13.42 33 73329 79318 64346052
Coronary artery disease 24.06 13.42 20 73342 60413 64364957
Clonus 24.00 13.42 32 73330 6035 64419335
Wheezing 23.96 13.42 34 73328 80545 64344825
Osteoporosis 23.83 13.42 9 73353 42071 64383299
Cellulitis 23.65 13.42 44 73318 93613 64331757
Clostridium difficile infection 23.59 13.42 6 73356 36157 64389213
Dysphoria 23.58 13.42 27 73335 4361 64421009
Polydipsia 23.48 13.42 31 73331 5790 64419580
Pericarditis 23.31 13.42 22 73340 62494 64362876
Hallucination, olfactory 23.14 13.42 11 73351 444 64424926
Atrial fibrillation 23.06 13.42 108 73254 170981 64254389
Delusion of reference 22.95 13.42 8 73354 142 64425228
Neurotoxicity 22.92 13.42 76 73286 27328 64398042
Rapid eye movement sleep behaviour disorder 22.89 13.42 10 73352 331 64425039
Rash pruritic 22.85 13.42 19 73343 57385 64367985
Influenza like illness 22.68 13.42 22 73340 61680 64363690
Feeling abnormal 22.65 13.42 77 73285 133525 64291845
Anticholinergic syndrome 22.65 13.42 21 73341 2648 64422722
Antipsychotic drug level above therapeutic 22.65 13.42 18 73344 1843 64423527
Ventricular fibrillation 22.54 13.42 69 73293 23791 64401579
Body temperature increased 22.51 13.42 92 73270 36574 64388796
Somatic hallucination 22.51 13.42 6 73356 40 64425330
Nephrogenic diabetes insipidus 22.43 13.42 18 73344 1869 64423501
Postoperative respiratory failure 22.35 13.42 8 73354 154 64425216
Respiratory depression 22.34 13.42 68 73294 23375 64401995
Hyperammonaemia 21.96 13.42 40 73322 9864 64415506
Disease progression 21.82 13.42 85 73277 141595 64283775
Thrombosis 21.81 13.42 29 73333 70613 64354757
Urinary tract infection 21.77 13.42 164 73198 231432 64193938
Localised infection 21.72 13.42 4 73358 30157 64395213
Poor personal hygiene 21.65 13.42 11 73351 514 64424856
Cataract 21.63 13.42 16 73346 51246 64374124
Pneumocystis jirovecii pneumonia 21.39 13.42 3 73359 27631 64397739
Inappropriate affect 21.36 13.42 15 73347 1273 64424097
Hepatic enzyme increased 21.29 13.42 76 73286 129867 64295503
Mydriasis 21.22 13.42 51 73311 15261 64410109
Rebound effect 21.10 13.42 27 73335 4890 64420480
Cytomegalovirus infection 20.99 13.42 8 73354 37191 64388179
Pneumonia 20.92 13.42 481 72881 559095 63866275
Haemoglobin decreased 20.86 13.42 133 73229 194930 64230440
Muscular weakness 20.51 13.42 75 73287 127263 64298107
Bone marrow eosinophilic leukocyte count increased 20.49 13.42 5 73357 22 64425348
Anaphylactic reaction 20.39 13.42 29 73333 68635 64356735
Electrocardiogram PR prolongation 20.36 13.42 15 73347 1372 64423998
Basal cell carcinoma 20.34 13.42 5 73357 30833 64394537
Increased appetite 20.04 13.42 39 73323 10107 64415263
Haemoglobin urine 19.99 13.42 7 73355 126 64425244
Obesity 19.93 13.42 60 73302 20502 64404868
Bone pain 19.88 13.42 15 73347 47557 64377813
False positive investigation result 19.85 13.42 12 73350 789 64424581
Cystitis 19.78 13.42 12 73350 42663 64382707
Self-medication 19.78 13.42 24 73338 4121 64421249
Abdominal pain 19.69 13.42 244 73118 312131 64113239
Myocardial reperfusion injury 19.65 13.42 5 73357 27 64425343
Folliculitis 19.60 13.42 5 73357 30072 64395298
Cerebral atrophy 19.53 13.42 32 73330 7253 64418117
Echopraxia 19.50 13.42 5 73357 28 64425342
Completed suicide 19.46 13.42 361 73001 224053 64201317
Screaming 19.44 13.42 22 73340 3507 64421863
Brain injury 19.31 13.42 38 73324 9927 64415443
Apallic syndrome 19.08 13.42 12 73350 847 64424523
Allergic hepatitis 19.07 13.42 5 73357 31 64425339
Femoral neck fracture 19.05 13.42 35 73327 8689 64416681
Physical assault 18.91 13.42 15 73347 1531 64423839
Lactate pyruvate ratio increased 18.87 13.42 6 73356 79 64425291
Encephalopathy 18.83 13.42 123 73239 58696 64366674
Drug withdrawal syndrome 18.80 13.42 78 73284 31213 64394157
Gastric disorder 18.75 13.42 5 73357 29192 64396178
Visual acuity reduced 18.70 13.42 4 73358 27137 64398233
Dry eye 18.58 13.42 5 73357 29014 64396356
Unevaluable event 18.56 13.42 18 73344 50471 64374899
Stress 18.54 13.42 25 73337 60509 64364861
Hyperthermia malignant 18.31 13.42 18 73344 2441 64422929
Drug diversion 18.31 13.42 13 73349 1123 64424247
Wrong patient received product 18.30 13.42 22 73340 3740 64421630
Fungal infection 18.30 13.42 8 73354 34243 64391127
Disorganised speech 18.06 13.42 15 73347 1635 64423735
Electroconvulsive therapy 18.03 13.42 6 73356 92 64425278
Anaphylactic shock 18.01 13.42 6 73356 30322 64395048
Amenorrhoea 17.90 13.42 29 73333 6510 64418860
COVID-19 17.90 13.42 29 73333 65111 64360259
Refusal of examination 17.85 13.42 6 73356 95 64425275
Lower respiratory tract infection 17.82 13.42 52 73310 94562 64330808
Osteonecrosis 17.82 13.42 5 73357 28224 64397146
Surgery 17.80 13.42 5 73357 28208 64397162
Heart rate decreased 17.63 13.42 22 73340 55045 64370325
Faecaloma 17.54 13.42 36 73326 9692 64415678
Haematuria 17.50 13.42 26 73336 60445 64364925
Pituitary tumour benign 17.48 13.42 17 73345 2276 64423094
Snoring 17.46 13.42 24 73338 4658 64420712
Exhibitionism 17.34 13.42 5 73357 46 64425324
Primary familial brain calcification 17.34 13.42 3 73359 0 64425370
Myelodysplastic syndrome 17.19 13.42 5 73357 27574 64397796
Rhinorrhoea 17.15 13.42 26 73336 59943 64365427
Metabolic syndrome 17.14 13.42 17 73345 2331 64423039
Gastrointestinal disorder 17.11 13.42 49 73313 89660 64335710
Mobility decreased 17.03 13.42 46 73316 85794 64339576
Oedema 16.97 13.42 51 73311 91884 64333486
Logorrhoea 16.97 13.42 22 73340 4037 64421333
Pulmonary arterial hypertension 16.95 13.42 4 73358 25363 64400007
Polydipsia psychogenic 16.95 13.42 7 73355 201 64425169
Gender dysphoria 16.88 13.42 5 73357 51 64425319
Upper respiratory tract infection 16.82 13.42 36 73326 72749 64352621
Nephrolithiasis 16.73 13.42 15 73347 43668 64381702
Ulcer 16.66 13.42 3 73359 22987 64402383
Angina pectoris 16.65 13.42 16 73346 45065 64380305
Judgement impaired 16.65 13.42 12 73350 1061 64424309
Vascular stenosis 16.59 13.42 9 73353 481 64424889
Swelling face 16.58 13.42 26 73336 59140 64366230
Grimacing 16.58 13.42 10 73352 655 64424715
Dyslipidaemia 16.43 13.42 34 73328 9208 64416162
Haemoptysis 16.33 13.42 19 73343 49029 64376341
Device issue 16.31 13.42 3 73359 22645 64402725
Duodenal stenosis 16.26 13.42 10 73352 678 64424692
Blood citric acid increased 16.22 13.42 5 73357 59 64425311
Paraphilia 16.14 13.42 5 73357 60 64425310
Tooth disorder 16.07 13.42 3 73359 22399 64402971
Therapeutic product effect variable 16.06 13.42 14 73348 1630 64423740
Visual impairment 16.01 13.42 38 73324 74039 64351331
Hypoxic-ischaemic encephalopathy 16.00 13.42 29 73333 7123 64418247
Drug ineffective for unapproved indication 15.96 13.42 74 73288 31059 64394311
Injection site haemorrhage 15.89 13.42 4 73358 24274 64401096
Anxiety 15.87 13.42 321 73041 202328 64223042
Perseveration 15.74 13.42 8 73354 374 64424996
Tonic clonic movements 15.64 13.42 15 73347 1974 64423396
Red blood cell sedimentation rate increased 15.61 13.42 8 73354 31227 64394143
Illness 15.60 13.42 3 73359 21935 64403435
Impaired self-care 15.52 13.42 16 73346 2297 64423073
Loss of consciousness 15.51 13.42 246 73116 148119 64277251
Chills 15.50 13.42 92 73270 137172 64288198
Myelosuppression 15.46 13.42 4 73358 23826 64401544
Neutropenia 15.41 13.42 369 72993 239255 64186115
Verbal abuse 15.34 13.42 7 73355 257 64425113
Hot flush 15.30 13.42 18 73344 46217 64379153
Tongue biting 15.23 13.42 14 73348 1746 64423624
Cerebrovascular stenosis 15.23 13.42 6 73356 152 64425218
Accidental overdose 15.22 13.42 77 73285 33480 64391890
Epileptic encephalopathy 15.21 13.42 8 73354 402 64424968
Poverty of speech 15.19 13.42 9 73353 570 64424800
Hypotonia 15.17 13.42 37 73325 11175 64414195
Bursitis 15.15 13.42 3 73359 21482 64403888
Posture abnormal 15.09 13.42 19 73343 3387 64421983
Mental disorder due to a general medical condition 15.00 13.42 7 73355 271 64425099
Substance-induced psychotic disorder 14.88 13.42 17 73345 2738 64422632
Skin discolouration 14.88 13.42 11 73351 35244 64390126
Osteonecrosis of jaw 14.87 13.42 14 73348 39811 64385559
Incoherent 14.84 13.42 28 73334 7090 64418280
Transient ischaemic attack 14.84 13.42 17 73345 44165 64381205
Presyncope 14.74 13.42 11 73351 35078 64390292
Scrotal haematoma 14.71 13.42 5 73357 82 64425288
Colitis ulcerative 14.68 13.42 4 73358 23024 64402346
Neoplasm progression 14.60 13.42 15 73347 40949 64384421
Vascular dementia 14.59 13.42 10 73352 816 64424554
Neck pain 14.59 13.42 30 73332 61503 64363867
Abdominal distension 14.51 13.42 58 73304 95936 64329434
Tachyphrenia 14.47 13.42 14 73348 1862 64423508
Eosinophilia 14.31 13.42 83 73279 37993 64387377
Hyperkinesia 14.25 13.42 16 73346 2530 64422840
Pulmonary hypertension 14.06 13.42 17 73345 43122 64382248
Hypomania 14.04 13.42 24 73338 5630 64419740
Intestinal dilatation 14.01 13.42 15 73347 2249 64423121
Eye swelling 13.96 13.42 4 73358 22277 64403093
Productive cough 13.95 13.42 40 73322 73163 64352207
Cyanosis 13.92 13.42 56 73306 22099 64403271
Diabetic coma 13.89 13.42 11 73351 1120 64424250
Affective disorder 13.86 13.42 26 73336 6554 64418816
Feeling hot 13.84 13.42 19 73343 45644 64379726
Oral herpes 13.84 13.42 4 73358 22148 64403222
Dysgeusia 13.84 13.42 20 73342 47027 64378343
Breathing-related sleep disorder 13.81 13.42 6 73356 196 64425174
Oral pain 13.80 13.42 7 73355 27486 64397884
Depressive symptom 13.78 13.42 21 73341 4475 64420895
Exposure to extreme temperature 13.74 13.42 3 73359 7 64425363
Dyspnoea paroxysmal nocturnal 13.69 13.42 14 73348 1990 64423380
Blood glucose 13.67 13.42 4 73358 39 64425331
Product dispensing error 13.63 13.42 36 73326 11414 64413956
Carnitine deficiency 13.61 13.42 6 73356 203 64425167
Blood pressure systolic increased 13.60 13.42 22 73340 49431 64375939
Polyneuropathy 13.57 13.42 3 73359 19891 64405479
Compulsions 13.54 13.42 7 73355 339 64425031
Subileus 13.53 13.42 22 73340 4955 64420415
Slow speech 13.50 13.42 14 73348 2023 64423347

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AD01 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Butyrophenone derivatives
MeSH PA D018726 Anti-Dyskinesia Agents
MeSH PA D000932 Antiemetics
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D015259 Dopamine Agents
MeSH PA D018492 Dopamine Antagonists
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:48279 serotonin antagonists
CHEBI has role CHEBI:48561 dopaminergic antagonists
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:65190 typical antipsychotic drugs
CHEBI has role CHEBI:66956 antidyskinetic agent
FDA EPC N0000180182 Typical Antipsychotic

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Gilles de la Tourette's syndrome indication 5158005 DOID:11119
Schizophrenia indication 58214004 DOID:5419
Psychotic disorder indication 69322001
Chronic schizophrenia indication 83746006
Delirium off-label use 2776000
Nausea and vomiting off-label use 16932000
Pain off-label use 22253000
Anxiety disorder off-label use 197480006 DOID:2030
Headache disorder off-label use 230461009
Gastroparesis off-label use 235675006
Chemotherapy-induced nausea and vomiting off-label use 236084000
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Thyrotoxic crisis contraindication 29028009 DOID:12837
Torsades de pointes contraindication 31722008
Parkinsonism contraindication 32798002
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Extrapyramidal disease contraindication 76349003
Leukopenia contraindication 84828003 DOID:615
Tardive dyskinesia contraindication 102449007
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Hypomagnesemia contraindication 190855004
Angina pectoris contraindication 194828000
Disease of liver contraindication 235856003 DOID:409
Retention of urine contraindication 267064002
Neutropenic disorder contraindication 303011007 DOID:1227
Coma contraindication 371632003
Breastfeeding (mother) contraindication 413712001
Central nervous system depression contraindication 418072004
Acquired torsion dystonia contraindication 433493000
Congenital long QT syndrome contraindication 442917000
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002
Drug Induced CNS Depression contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.36 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR INVERSE AGONIST Ki 9.15 WOMBAT-PK CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.30 PDSP
Mu-type opioid receptor GPCR Ki 6.00 DRUG MATRIX
D(1A) dopamine receptor GPCR Ki 7.82 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 5.95 PDSP
Sigma non-opioid intracellular receptor 1 Membrane receptor EC50 8.92 WOMBAT-PK
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Enzyme Ki 6.72 WOMBAT-PK
Multidrug resistance protein 1 Transporter Ki 6.70 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 5.74 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.74 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Ki 5.55 CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 7 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 6.10 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR Ki 5.33 CHEMBL
5-hydroxytryptamine receptor 6 GPCR Ki 5.22 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 6.45 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 7.90 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 6.32 PDSP
D(3) dopamine receptor GPCR INVERSE AGONIST Ki 8.52 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 7.52 WOMBAT-PK
Histamine H1 receptor GPCR Ki 6.36 CHEMBL
Histamine H2 receptor GPCR Ki 6.00 PDSP
Muscarinic acetylcholine receptor M1 GPCR Ki 5.80 CHEMBL
Muscarinic acetylcholine receptor M3 GPCR Ki 5 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 6.18 PDSP
5-hydroxytryptamine receptor 1B GPCR Ki 6.57 PDSP
5-hydroxytryptamine receptor 1D GPCR ANTAGONIST Ki 6.60 IUPHAR
Alpha-2C adrenergic receptor GPCR Ki 6.26 PDSP
Alpha-1D adrenergic receptor GPCR Ki 7.55 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 8.10 PDSP
Calmodulin Cytosolic other IC50 6.30 WOMBAT-PK
5-hydroxytryptamine receptor 5A GPCR Ki 5.65 PDSP
5-hydroxytryptamine receptor 1F GPCR Ki 5.30 PDSP
5-hydroxytryptamine receptor 1E GPCR Ki 5.30 PDSP
Potassium channel subfamily K member 2 Ion channel IC50 5.26 CHEMBL
Potassium voltage-gated channel subfamily H member 1 Ion channel BLOCKER IC50 6.20 IUPHAR
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 5.92 CHEMBL
Histone H1.0 Nuclear other Ki 6.11 CHEMBL
Transmembrane protein 97 Enzyme Ki 7.80 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 7.50 WOMBAT-PK
D(4) dopamine receptor GPCR INVERSE AGONIST Kd 9.42 SCIENTIFIC LITERATURE
Alpha-1B adrenergic receptor GPCR Ki 8.31 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 7.44 DRUG MATRIX
Pol polyprotein Enzyme Ki 7 CHEMBL
Alpha-1A adrenergic receptor GPCR Kd 7.76 CHEMBL
Histamine H1 receptor GPCR Ki 6.40 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 6.62 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 5.74 CHEMBL
D(2) dopamine receptor GPCR Ki 9.70 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.40 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 7.35 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 9.05 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 6.58 CHEMBL
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 6.30 IUPHAR
D(1A) dopamine receptor GPCR Ki 7.70 CHEMBL
D(2) dopamine receptor GPCR Ki 9.52 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 7.70 CHEMBL
Histamine H1 receptor GPCR Ki 6.42 CHEMBL
D(3) dopamine receptor GPCR Ki 8.52 CHEMBL
Protease Enzyme Ki 7 CHEMBL
D(2) dopamine receptor GPCR Ki 8.32 CHEMBL
5-hydroxytryptamine receptor 2A GPCR IC50 7.52 CHEMBL
C-8 sterol isomerase Enzyme Ki 9.30 CHEMBL
D(1A) dopamine receptor GPCR Ki 7.03 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane other Ki 9.08 CHEMBL
Transporter Transporter Ki 5.26 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 7.52 CHEMBL
D(3) dopamine receptor GPCR Ki 8.52 CHEMBL
Vesicular acetylcholine transporter Transporter Ki 6.41 CHEMBL
AP-2 complex subunit sigma Unclassified Ki 7.62 CHEMBL
Muscarinic acetylcholine receptor GPCR Ki 5.13 CHEMBL
Opioid receptor GPCR Ki 5.92 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR IC50 4.70 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 5.57 CHEMBL
Dopamine receptor GPCR IC50 8.74 CHEMBL
Dopamine receptor GPCR Ki 8.70 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 8.38 CHEMBL
Adenylate cyclase Enzyme IC50 5.64 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 7.58 CHEMBL
G protein-activated inward rectifier potassium channel 2 Ion channel GATING INHIBITOR EC50 4.10 IUPHAR
Sigma intracellular receptor 2 Unclassified Ki 7.36 CHEMBL
Zinc finger protein 664 Unclassified Ki 8.18 CHEMBL

External reference:

IDSource
4018123 VUID
N0000146461 NUI
D00136 KEGG_DRUG
53515-91-6 SECONDARY_CAS_RN
4018123 VANDF
4018125 VANDF
C0018546 UMLSCUI
CHEBI:5613 CHEBI
GMJ PDB_CHEM_ID
CHEMBL54 ChEMBL_ID
DB00502 DRUGBANK_ID
CHEMBL2096643 ChEMBL_ID
CHEMBL4297147 ChEMBL_ID
D006220 MESH_DESCRIPTOR_UI
3559 PUBCHEM_CID
86 IUPHAR_LIGAND_ID
918 INN_ID
J6292F8L3D UNII
217483 RXNORM
2958 MMSL
4816 MMSL
4818 MMSL
583 MMSL
d00027 MMSL
001518 NDDF
001521 NDDF
10756001 SNOMEDCT_US
386837002 SNOMEDCT_US
412197008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0121-0581 SOLUTION 2 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0121-0581 SOLUTION 2 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0143-9319 INJECTION 5 mg INTRAMUSCULAR ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0143-9501 INJECTION 5 mg INTRAMUSCULAR ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0143-9502 INJECTION 5 mg INTRAMUSCULAR ANDA 16 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0214 TABLET 2 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0257 TABLET 1 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0327 TABLET 5 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0334 TABLET 10 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0335 TABLET 20 mg ORAL ANDA 17 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0351 TABLET 0.50 mg ORAL ANDA 17 sections
Haloperidol Lactate HUMAN PRESCRIPTION DRUG LABEL 1 0404-9871 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 12 sections
Haloperidol Lactate HUMAN PRESCRIPTION DRUG LABEL 1 0404-9871 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 12 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8355 TABLET 5 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0832-1510 TABLET 0.50 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0832-1520 TABLET 1 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0832-1530 TABLET 2 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0832-1540 TABLET 5 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0832-1550 TABLET 10 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0832-1560 TABLET 20 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-5923 TABLET 1 mg ORAL ANDA 18 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-5924 TABLET 2 mg ORAL ANDA 18 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-5925 TABLET 5 mg ORAL ANDA 18 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6413 TABLET 10 mg ORAL ANDA 18 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6661 TABLET 20 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6733 TABLET 10 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6782 TABLET 5 mg ORAL ANDA 15 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 0904-7112 SOLUTION 2 mg ORAL ANDA 13 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 17478-110 INJECTION 5 mg INTRAMUSCULAR ANDA 25 sections
Haloperidol HUMAN PRESCRIPTION DRUG LABEL 1 17856-0501 SOLUTION 2 mg ORAL ANDA 13 sections