leucovorin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1232 58-05-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sodium folinate
  • folinic acid
  • leucovorin
  • calcium folinate
  • leucovorin calcium
  • folinic acid calcium salt
  • folinic acid calcium
  • wellcovorin
  • folinic acid calcium salt pentahydrate
The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.
  • Molecular weight: 473.45
  • Formula: C20H23N7O7
  • CLOGP: -3.49
  • LIPINSKI: 2
  • HAC: 14
  • HDO: 7
  • TPSA: 215.55
  • ALOGS: -3.20
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
60 mg O
60 mg P
60 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 500 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability) 4 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.25 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 5.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.09 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 20, 1952 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 1560.82 50.55 457 4210 21091 2332327
Diarrhoea 1371.44 50.55 585 4082 82979 2270439
Vomiting 883.76 50.55 413 4254 71189 2282229
Nausea 781.97 50.55 440 4227 111749 2241669
Febrile neutropenia 770.22 50.55 228 4439 10654 2342764
Thrombocytopenia 594.39 50.55 215 4452 18916 2334502
Mucosal inflammation 589.95 50.55 158 4509 5066 2348352
Abdominal pain 586.42 50.55 250 4417 34124 2319294
Stomatitis 534.73 50.55 168 4499 9542 2343876
Neuropathy peripheral 532.00 50.55 174 4493 11258 2342160
Dehydration 491.10 50.55 195 4472 22100 2331318
Pulmonary embolism 439.61 50.55 170 4497 17913 2335505
Pyrexia 425.76 50.55 231 4436 53477 2299941
Leukopenia 425.27 50.55 143 4524 10053 2343365
Anaemia 410.65 50.55 196 4471 34596 2318822
Neurotoxicity 406.10 50.55 98 4569 2032 2351386
Hypertension 387.53 50.55 175 4492 27186 2326232
Disease progression 384.55 50.55 152 4515 16943 2336475
General physical health deterioration 361.43 50.55 138 4529 14001 2339417
Asthenia 357.97 50.55 197 4470 46729 2306689
Malignant neoplasm progression 294.12 50.55 114 4553 12014 2341404
Fatigue 279.95 50.55 210 4457 84663 2268755
Posterior reversible encephalopathy syndrome 255.92 50.55 70 4597 2410 2351008
Hypokalaemia 254.16 50.55 99 4568 10555 2342863
Sepsis 229.07 50.55 108 4559 18380 2335038
Off label use 226.55 50.55 175 4492 73423 2279995
Polyneuropathy 192.28 50.55 52 4615 1711 2351707
Palmar-plantar erythrodysaesthesia syndrome 186.96 50.55 62 4605 4139 2349279
Decreased appetite 186.28 50.55 109 4558 28782 2324636
Bone marrow failure 172.30 50.55 63 4604 5623 2347795
Haemoglobin decreased 165.13 50.55 86 4581 18065 2335353
Hypomagnesaemia 155.90 50.55 48 4619 2516 2350902
Ileus 154.99 50.55 46 4621 2126 2351292
Dyspnoea 153.07 50.55 144 4523 78589 2274829
Device related infection 152.61 50.55 50 4617 3209 2350209
Urinary tract infection 147.05 50.55 95 4572 29847 2323571
Haematotoxicity 139.40 50.55 37 4630 1130 2352288
Colorectal cancer metastatic 135.64 50.55 26 4641 165 2353253
Peripheral sensory neuropathy 134.27 50.55 35 4632 995 2352423
White blood cell count decreased 134.07 50.55 75 4592 18133 2335285
Metastases to liver 133.19 50.55 44 4623 2897 2350521
Respiratory failure 131.33 50.55 67 4600 13461 2339957
Deep vein thrombosis 131.24 50.55 66 4601 12866 2340552
Pancytopenia 126.73 50.55 62 4605 11390 2342028
Septic shock 124.92 50.55 53 4614 7001 2346417
Neoplasm progression 124.08 50.55 47 4620 4621 2348797
Interstitial lung disease 122.95 50.55 54 4613 7758 2345660
Enteritis 122.93 50.55 33 4634 1053 2352365
Acute kidney injury 122.91 50.55 83 4584 28039 2325379
Chills 122.53 50.55 67 4600 15485 2337933
Hypotension 119.04 50.55 86 4581 32350 2321068
Pneumonia 118.93 50.55 102 4565 49194 2304224
Gastrointestinal toxicity 116.87 50.55 28 4639 558 2352860
Intestinal obstruction 108.74 50.55 42 4625 4351 2349067
Proteinuria 106.82 50.55 37 4630 2813 2350605
Multiple organ dysfunction syndrome 104.86 50.55 48 4619 7593 2345825
Infection 102.92 50.55 63 4604 17966 2335452
Platelet count decreased 102.58 50.55 60 4607 15753 2337665
Renal failure 102.57 50.55 62 4605 17287 2336131
Alopecia 101.03 50.55 67 4600 21934 2331484
Neutrophil count decreased 98.82 50.55 44 4623 6523 2346895
Intestinal perforation 98.24 50.55 31 4636 1760 2351658
Constipation 97.22 50.55 65 4602 21564 2331854
Toxicity to various agents 96.09 50.55 76 4591 32678 2320740
Small intestinal obstruction 95.65 50.55 32 4635 2188 2351230
Skin toxicity 94.11 50.55 25 4642 765 2352653
Atrial fibrillation 93.96 50.55 54 4613 13714 2339704
Maternal exposure during pregnancy 92.73 50.55 55 4612 14808 2338610
Ascites 92.14 50.55 40 4627 5580 2347838
Chest pain 90.59 50.55 69 4598 28068 2325350
Dermatitis acneiform 88.81 50.55 24 4643 785 2352633
Metastases to lung 86.86 50.55 28 4639 1703 2351715
Epistaxis 84.99 50.55 45 4622 9734 2343684
Paraesthesia 84.22 50.55 60 4607 22028 2331390
Hypersensitivity 82.92 50.55 61 4606 23532 2329886
Seizure 78.73 50.55 60 4607 24406 2329012
Arteriospasm coronary 78.39 50.55 21 4646 664 2352754
Rash 77.45 50.55 88 4579 59470 2293948
Death 74.78 50.55 101 4566 81367 2272051
Metastases to meninges 74.31 50.55 18 4649 376 2353042
Clostridium difficile colitis 74.08 50.55 26 4641 2053 2351365
Syncope 74.07 50.55 50 4617 16825 2336593
Pain 73.07 50.55 87 4580 61770 2291648
Pleural effusion 72.29 50.55 43 4624 11625 2341793
Abdominal pain upper 70.65 50.55 54 4613 22046 2331372
Paronychia 70.08 50.55 20 4647 802 2352616
Embolism 68.99 50.55 22 4645 1291 2352127
Neoplasm recurrence 67.94 50.55 17 4650 408 2353010
Hypophagia 67.29 50.55 29 4638 3971 2349447
Nasal septum perforation 66.59 50.55 14 4653 149 2353269
Cardiomyopathy 66.48 50.55 26 4641 2781 2350637
Hydronephrosis 65.63 50.55 21 4646 1246 2352172
Splenomegaly 65.39 50.55 22 4645 1529 2351889
Cholangitis 64.41 50.55 19 4648 857 2352561
Encephalopathy 63.63 50.55 29 4638 4532 2348886
Blood creatinine increased 63.11 50.55 38 4629 10495 2342923
Aortic thrombosis 62.79 50.55 14 4653 200 2353218
Hyperammonaemic encephalopathy 61.89 50.55 15 4652 314 2353104
Large intestine perforation 61.62 50.55 20 4647 1242 2352176
Pulmonary oedema 61.47 50.55 33 4634 7330 2346088
Multiple-drug resistance 61.14 50.55 14 4653 227 2353191
Tumour lysis syndrome 60.58 50.55 19 4648 1056 2352362
Cholestasis 59.40 50.55 26 4641 3695 2349723
Neutropenic sepsis 59.00 50.55 20 4647 1422 2351996
Dysphagia 58.71 50.55 39 4628 12766 2340652
Product use in unapproved indication 58.45 50.55 37 4630 11163 2342255
Cystitis radiation 58.15 50.55 9 4658 10 2353408
Human bocavirus infection 57.69 50.55 9 4658 11 2353407
Venoocclusive liver disease 57.29 50.55 16 4651 592 2352826
Acute lymphocytic leukaemia recurrent 56.58 50.55 13 4654 214 2353204
Premature delivery 56.46 50.55 24 4643 3176 2350242
Gastrointestinal disorder 55.57 50.55 33 4634 8884 2344534
Alanine aminotransferase increased 55.48 50.55 39 4628 13993 2339425
Hypocalcaemia 55.15 50.55 25 4642 3858 2349560
Hyponatraemia 54.94 50.55 38 4629 13287 2340131
Dysphonia 54.46 50.55 29 4638 6335 2347083
Colorectal cancer 54.39 50.55 13 4654 256 2353162
Enterobacter infection 54.15 50.55 13 4654 261 2353157
Colitis 53.90 50.55 27 4640 5199 2348219
Pneumothorax 53.28 50.55 21 4646 2291 2351127
Superior vena cava syndrome 53.03 50.55 11 4656 109 2353309
Bladder tamponade 52.65 50.55 9 4658 26 2353392
Venous thrombosis 52.55 50.55 16 4651 805 2352613
Herpes simplex 52.46 50.55 17 4650 1050 2352368
Dysarthria 51.91 50.55 28 4639 6274 2347144
Hemiparesis 51.50 50.55 23 4644 3427 2349991
Stress cardiomyopathy 51.01 50.55 18 4649 1443 2351975
Blood alkaline phosphatase increased 50.92 50.55 28 4639 6517 2346901

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Diarrhoea 1934.68 48.45 843 5805 53009 1687124
Neutropenia 1537.52 48.45 534 6114 17726 1722407
Neuropathy peripheral 908.69 48.45 305 6343 8948 1731185
Nausea 863.11 48.45 483 6165 50713 1689420
Pyrexia 798.12 48.45 444 6204 45956 1694177
Vomiting 764.80 48.45 405 6243 37910 1702223
Febrile neutropenia 690.55 48.45 261 6387 10839 1729294
Abdominal pain 662.35 48.45 306 6342 21184 1718949
Thrombocytopenia 618.72 48.45 291 6357 20958 1719175
Dehydration 608.59 48.45 272 6376 17386 1722747
Decreased appetite 592.46 48.45 293 6355 23578 1716555
Mucosal inflammation 569.71 48.45 177 6471 3992 1736141
Fatigue 511.07 48.45 346 6302 50435 1689698
General physical health deterioration 473.46 48.45 209 6439 12909 1727224
Disease progression 472.83 48.45 227 6421 17036 1723097
Stomatitis 454.29 48.45 159 6489 5245 1734888
Asthenia 430.51 48.45 270 6378 34400 1705733
Metastases to liver 398.60 48.45 117 6531 2150 1737983
Off label use 387.25 48.45 263 6385 38308 1701825
Pulmonary embolism 385.52 48.45 181 6467 12878 1727255
Palmar-plantar erythrodysaesthesia syndrome 344.38 48.45 116 6532 3391 1736742
Leukopenia 331.09 48.45 143 6505 8337 1731796
Anaemia 326.80 48.45 214 6434 29243 1710890
Hypertension 322.84 48.45 183 6465 19265 1720868
Chills 314.23 48.45 152 6496 11535 1728598
Malignant neoplasm progression 312.43 48.45 161 6487 13997 1726136
Interstitial lung disease 309.54 48.45 142 6506 9554 1730579
Acute kidney injury 298.25 48.45 216 6432 34728 1705405
Sepsis 267.30 48.45 162 6486 19276 1720857
Dermatitis acneiform 265.16 48.45 72 6576 980 1739153
Neurotoxicity 255.43 48.45 81 6567 1943 1738190
Skin toxicity 253.74 48.45 62 6586 537 1739596
Constipation 245.52 48.45 140 6508 14860 1725273
Peripheral sensory neuropathy 221.98 48.45 60 6588 801 1739332
Colorectal cancer metastatic 220.97 48.45 47 6601 199 1739934
Ascites 220.41 48.45 95 6553 5491 1734642
Intestinal obstruction 219.06 48.45 83 6565 3424 1736709
Dyspnoea 200.47 48.45 204 6444 51855 1688278
Small intestinal obstruction 197.38 48.45 65 6583 1762 1738371
Deep vein thrombosis 193.45 48.45 104 6544 9816 1730317
Proteinuria 191.01 48.45 71 6577 2773 1737360
Neoplasm progression 188.53 48.45 73 6575 3194 1736939
Epistaxis 184.45 48.45 95 6553 8211 1731922
Skin reaction 182.15 48.45 55 6593 1113 1739020
Alopecia 182.14 48.45 74 6574 3679 1736454
Weight decreased 180.78 48.45 135 6513 22618 1717515
Urinary tract infection 177.39 48.45 99 6549 10054 1730079
Pneumonia 172.20 48.45 178 6470 46004 1694129
Metastases to lung 171.39 48.45 56 6592 1479 1738654
Hypokalaemia 165.27 48.45 81 6567 6293 1733840
Polyneuropathy 164.03 48.45 56 6592 1699 1738434
Hypotension 159.34 48.45 140 6508 29514 1710619
Paraesthesia 158.68 48.45 93 6555 10358 1729775
Respiratory failure 156.84 48.45 104 6544 14401 1725732
Ileus 149.47 48.45 57 6591 2389 1737744
Gastrointestinal toxicity 147.68 48.45 37 6611 358 1739775
Bone marrow failure 140.53 48.45 68 6580 5132 1735001
Haemoglobin decreased 139.04 48.45 103 6545 17011 1723122
Tachycardia 137.58 48.45 91 6557 12537 1727596
Neutrophil count decreased 136.21 48.45 70 6578 6011 1734122
Oesophagitis 134.80 48.45 48 6600 1653 1738480
Paronychia 133.59 48.45 37 6611 543 1739590
Renal failure 128.95 48.45 105 6543 19912 1720221
Infection 127.25 48.45 86 6562 12274 1727859
Cholangitis 127.17 48.45 42 6606 1147 1738986
Abdominal pain lower 126.55 48.45 42 6606 1165 1738968
Rash 126.06 48.45 139 6509 38554 1701579
Device related infection 124.49 48.45 49 6599 2237 1737896
Septic shock 122.60 48.45 72 6576 8037 1732096
Chest pain 118.95 48.45 100 6548 19814 1720319
Hiccups 118.24 48.45 42 6606 1435 1738698
Blood creatinine increased 115.61 48.45 85 6563 13861 1726272
C-reactive protein increased 115.44 48.45 62 6586 5823 1734310
Circulatory collapse 114.22 48.45 52 6596 3415 1736718
Pleural effusion 113.62 48.45 77 6571 11033 1729100
Colitis 110.92 48.45 54 6594 4126 1736007
Hypoalbuminaemia 103.69 48.45 38 6610 1422 1738711
Enteritis 102.39 48.45 34 6614 944 1739189
Blood bilirubin increased 101.44 48.45 58 6590 6152 1733981
Proteus infection 101.42 48.45 22 6626 104 1740029
Portal hypertension 101.35 48.45 31 6617 655 1739478
Tumour lysis syndrome 100.51 48.45 39 6609 1712 1738421
Intestinal perforation 99.86 48.45 38 6610 1581 1738552
Neutropenic sepsis 99.21 48.45 37 6611 1455 1738678
Colorectal cancer 97.10 48.45 27 6621 402 1739731
Necrotising fasciitis 94.49 48.45 29 6619 620 1739513
Subclavian vein thrombosis 93.48 48.45 22 6626 159 1739974
White blood cell count decreased 93.17 48.45 73 6575 13076 1727057
Erythema 92.48 48.45 75 6573 14113 1726020
Pain 92.30 48.45 99 6549 26558 1713575
Jaundice 92.05 48.45 54 6594 6008 1734125
Colitis microscopic 91.93 48.45 25 6623 341 1739792
Leukocytosis 91.80 48.45 45 6603 3488 1736645
Hypophagia 89.25 48.45 44 6604 3453 1736680
Arteriospasm coronary 88.41 48.45 28 6620 666 1739467
Hypomagnesaemia 86.99 48.45 37 6611 2061 1738072
Oedema peripheral 86.47 48.45 75 6573 15475 1724658
Carcinoembryonic antigen increased 85.26 48.45 21 6627 188 1739945
Hypersensitivity 85.02 48.45 63 6585 10381 1729752
Back pain 84.16 48.45 76 6572 16537 1723596
Blood potassium decreased 83.79 48.45 37 6611 2258 1737875
Hepatotoxicity 82.28 48.45 40 6608 3044 1737089
Foetal disorder 81.90 48.45 17 6631 62 1740071
Peritonitis 80.60 48.45 38 6610 2701 1737432
Klebsiella infection 80.02 48.45 27 6621 788 1739345
Clostridial infection 79.65 48.45 26 6622 683 1739450
Lethargy 78.70 48.45 52 6596 7132 1733001
Inflammation 78.03 48.45 40 6608 3410 1736723
Cachexia 77.94 48.45 28 6620 988 1739145
Prothrombin level decreased 76.20 48.45 20 6628 236 1739897
Haematotoxicity 75.75 48.45 27 6621 931 1739202
Abdominal pain upper 75.59 48.45 60 6588 10941 1729192
Oral pain 75.55 48.45 30 6618 1400 1738733
Dysphagia 75.36 48.45 58 6590 10110 1730023
Coagulopathy 73.97 48.45 36 6612 2745 1737388
Blood lactic acid increased 73.60 48.45 26 6622 873 1739260
Induration 73.52 48.45 19 6629 210 1739923
Gastrointestinal perforation 73.38 48.45 25 6623 752 1739381
Syncope 72.09 48.45 65 6583 14104 1726029
Neutropenia neonatal 71.99 48.45 14 6634 33 1740100
Bacteraemia 70.86 48.45 31 6617 1849 1738284
Hepatic failure 67.75 48.45 44 6604 5859 1734274
Large intestine perforation 66.66 48.45 26 6622 1156 1738977
Febrile infection 66.62 48.45 17 6631 178 1739955
Neoplasm recurrence 66.55 48.45 20 6628 397 1739736
Liver abscess 66.30 48.45 22 6626 609 1739524
Hyperglycaemia 65.49 48.45 41 6607 5124 1735009
Atrial fibrillation 64.72 48.45 63 6585 15048 1725085
Posterior reversible encephalopathy syndrome 64.43 48.45 27 6621 1448 1738685
Abdominal distension 64.24 48.45 44 6604 6400 1733733
Aspartate aminotransferase increased 64.08 48.45 54 6594 10702 1729431
Candida infection 63.30 48.45 29 6619 1929 1738204
Mouth ulceration 63.11 48.45 28 6620 1727 1738406
Rash pustular 63.11 48.45 25 6623 1159 1738974
Dry mouth 62.40 48.45 36 6612 3877 1736256
Organising pneumonia 62.37 48.45 23 6625 875 1739258
Haematochezia 62.15 48.45 39 6609 4893 1735240
Vena cava thrombosis 61.83 48.45 17 6631 242 1739891
Loss of consciousness 61.81 48.45 61 6587 14814 1725319
Adenocarcinoma of colon 60.71 48.45 19 6629 434 1739699
Systemic inflammatory response syndrome 59.99 48.45 22 6626 824 1739309
Venous thrombosis 59.90 48.45 21 6627 689 1739444
Alanine aminotransferase increased 59.85 48.45 55 6593 12223 1727910
Toxicity to various agents 59.61 48.45 83 6565 29058 1711075
Hyperammonaemic encephalopathy 59.57 48.45 18 6630 364 1739769
Angina pectoris 59.05 48.45 38 6610 4980 1735153
Fall 57.89 48.45 79 6569 27135 1712998
Blood alkaline phosphatase increased 57.84 48.45 38 6610 5157 1734976
Haematocrit decreased 56.90 48.45 35 6613 4238 1735895
Neutrophilia 56.19 48.45 19 6629 558 1739575
Thrombosis 55.92 48.45 43 6605 7478 1732655
Tenderness 55.88 48.45 22 6626 1003 1739130
Conjunctivitis 55.41 48.45 25 6623 1604 1738529
Low birth weight baby 55.34 48.45 21 6627 866 1739267
Acute coronary syndrome 55.26 48.45 28 6620 2327 1737806
Premature baby 54.88 48.45 30 6618 2912 1737221
Platelet count decreased 54.70 48.45 60 6588 16463 1723670
Rectal haemorrhage 53.25 48.45 37 6611 5505 1734628
Metastases to peritoneum 52.84 48.45 16 6632 326 1739807
Large intestinal obstruction 52.64 48.45 15 6633 245 1739888
Muscular weakness 52.07 48.45 47 6601 10202 1729931
Dyspepsia 51.96 48.45 35 6613 4950 1735183
Recall phenomenon 51.66 48.45 13 6635 128 1740005
Hyperammonaemia 51.36 48.45 21 6627 1057 1739076
Abscess 51.32 48.45 25 6623 1909 1738224
Pancreatic carcinoma metastatic 51.30 48.45 18 6630 592 1739541
Embolism 50.64 48.45 21 6627 1096 1739037
Malnutrition 50.42 48.45 23 6625 1514 1738619
Pneumatosis intestinalis 50.09 48.45 17 6631 505 1739628
Perihepatic abscess 49.98 48.45 9 6639 11 1740122
Rectal abscess 49.81 48.45 14 6634 217 1739916
Endocarditis 49.62 48.45 20 6628 970 1739163
Dysphonia 49.59 48.45 30 6618 3525 1736608
Stoma site pain 49.55 48.45 11 6637 59 1740074
Gastrointestinal inflammation 49.46 48.45 17 6631 525 1739608
Flushing 49.10 48.45 37 6611 6242 1733891
Cough 49.01 48.45 61 6587 19136 1720997
Oesophageal haemorrhage 48.94 48.45 14 6634 232 1739901
Hypoxia 48.55 48.45 36 6612 5927 1734206

Pharmacologic Action:

SourceCodeDescription
ATC V03AF03 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Detoxifying agents for antineoplastic treatment
ATC V03AF06 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Detoxifying agents for antineoplastic treatment
FDA EPC N0000178369 Folate Analog
FDA CS M0008658 Folic Acid
MeSH PA D000931 Antidotes
MeSH PA D018977 Micronutrients
MeSH PA D020011 Protective Agents
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Megaloblastic anemia indication 53165003 DOID:13382
Folic acid deficiency indication 190633005
Bone Marrow Suppression due to Folic Acid Antagonism indication
Methotrexate Toxicity indication
Trimethoprim Toxicity indication
Trimetrexate Toxicity indication
Sulfadiazine Toxicity indication
Pyrimethamine Toxicity indication
Adjunct to Fluorouracil Treatment of Colorectal Cancer indication
Pernicious anemia contraindication 84027009 DOID:13381
Cobalamin deficiency contraindication 190634004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.61 acidic
pKa2 5.29 acidic
pKa3 10.26 acidic
pKa4 12.96 acidic
pKa5 4.59 Basic
pKa6 2.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Thymidylate synthase Enzyme Ki 4.07 WOMBAT-PK
Dihydrofolate reductase Enzyme Ki 5.63 CHEMBL

External reference:

IDSource
D002955 MESH_DESCRIPTOR_UI
4019798 VUID
N0000147887 NUI
C0023413 UMLSCUI
D01211 KEGG_DRUG
1528001 SNOMEDCT_US
396065004 SNOMEDCT_US
6313 RXNORM
d00275 MMSL
4019798 VANDF
001050 NDDF
DB00650 DRUGBANK_ID
CHEMBL1679 ChEMBL_ID
Q573I9DVLP UNII
690 INN_ID
1492-18-8 SECONDARY_CAS_RN
CHEBI:31340 CHEBI
CHEMBL1201138 ChEMBL_ID
CHEMBL1232801 ChEMBL_ID
CHEMBL3707260 ChEMBL_ID
135403648 PUBCHEM_CID
4816 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0054-4496 TABLET 5 mg ORAL ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0054-4497 TABLET 10 mg ORAL ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0054-4498 TABLET 15 mg ORAL ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0054-4499 TABLET 25 mg ORAL ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0054-8496 TABLET 5 mg ORAL ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9368 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 200 mg INTRAMUSCULAR ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9552 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 350 mg INTRAMUSCULAR ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9553 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 200 mg INTRAMUSCULAR ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9554 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAMUSCULAR ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9555 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 50 mg INTRAMUSCULAR ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0555-0484 TABLET 5 mg ORAL ANDA 13 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0555-0485 TABLET 25 mg ORAL ANDA 13 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0703-5140 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAMUSCULAR ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0703-5145 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 350 mg INTRAMUSCULAR ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0904-6703 TABLET 25 mg ORAL ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 25021-813 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 50 mg INTRAVENOUS ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 25021-814 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 25021-815 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 200 mg INTRAVENOUS ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 25021-816 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 350 mg INTRAVENOUS ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 25021-828 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 12 sections
LEUCOVORIN CALCIUM HUMAN PRESCRIPTION DRUG LABEL 1 50742-464 INJECTION, SOLUTION 10 mg INTRAMUSCULAR ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 51079-581 TABLET 5 mg ORAL ANDA 13 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 51079-582 TABLET 25 mg ORAL ANDA 13 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 54868-3310 TABLET 5 mg ORAL ANDA 13 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 54868-5915 TABLET 15 mg ORAL ANDA 13 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 60687-227 TABLET 25 mg ORAL ANDA 13 sections
Leucovorin calcium HUMAN PRESCRIPTION DRUG LABEL 1 63323-631 INJECTION 10 mg INTRAVENOUS ANDA 11 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 63323-710 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 200 mg INTRAMUSCULAR ANDA 13 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 63323-711 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAMUSCULAR ANDA 13 sections
EnBrace HR HUMAN PRESCRIPTION DRUG LABEL 5 64661-650 CAPSULE, DELAYED RELEASE PELLETS 2.50 mg ORAL UNAPPROVED DRUG OTHER 12 sections