Stem definition | Drug id | CAS RN |
---|---|---|
1232 | 58-05-9 |
Dose | Unit | Route |
---|---|---|
60 | mg | O |
60 | mg | P |
60 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 500 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 10 % | Benet LZ, Broccatelli F, Oprea TI |
BA (Bioavailability) | 4 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.25 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 5.80 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.09 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.30 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
June 20, 1952 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neutropenia | 975.88 | 11.53 | 1003 | 54474 | 158182 | 53135407 |
Mucosal inflammation | 510.94 | 11.53 | 394 | 55083 | 42390 | 53251199 |
Neuropathy peripheral | 496.17 | 11.53 | 573 | 54904 | 102614 | 53190975 |
Neurotoxicity | 459.80 | 11.53 | 252 | 55225 | 15097 | 53278492 |
Thrombocytopenia | 408.52 | 11.53 | 605 | 54872 | 138122 | 53155467 |
Diarrhoea | 331.08 | 11.53 | 1403 | 54074 | 624143 | 52669446 |
Disease progression | 301.94 | 11.53 | 446 | 55031 | 101474 | 53192115 |
Febrile neutropenia | 287.82 | 11.53 | 443 | 55034 | 104493 | 53189096 |
Skin toxicity | 245.60 | 11.53 | 108 | 55369 | 3985 | 53289604 |
Colorectal cancer metastatic | 206.93 | 11.53 | 63 | 55414 | 784 | 53292805 |
Polyneuropathy | 189.45 | 11.53 | 136 | 55341 | 13097 | 53280492 |
Leukopenia | 184.48 | 11.53 | 298 | 55179 | 73165 | 53220424 |
Stomatitis | 183.91 | 11.53 | 350 | 55127 | 97808 | 53195781 |
Dermatitis acneiform | 178.45 | 11.53 | 89 | 55388 | 4381 | 53289208 |
Haematotoxicity | 170.88 | 11.53 | 105 | 55372 | 7792 | 53285797 |
Vomiting | 161.19 | 11.53 | 973 | 54504 | 496166 | 52797423 |
Posterior reversible encephalopathy syndrome | 152.89 | 11.53 | 130 | 55347 | 16030 | 53277559 |
Palmar-plantar erythrodysaesthesia syndrome | 138.73 | 11.53 | 140 | 55337 | 21466 | 53272123 |
Pancytopenia | 135.57 | 11.53 | 295 | 55182 | 90633 | 53202956 |
Pulmonary embolism | 124.96 | 11.53 | 329 | 55148 | 114113 | 53179476 |
Metastases to liver | 123.10 | 11.53 | 131 | 55346 | 21365 | 53272224 |
Nausea | 116.81 | 11.53 | 1248 | 54229 | 754843 | 52538746 |
Malignant neoplasm progression | 113.40 | 11.53 | 238 | 55239 | 71303 | 53222286 |
Bone marrow failure | 113.29 | 11.53 | 148 | 55329 | 29967 | 53263622 |
Anaemia | 111.55 | 11.53 | 575 | 54902 | 276143 | 53017446 |
Systemic lupus erythematosus | 109.25 | 11.53 | 5 | 55472 | 125409 | 53168180 |
Abdominal pain | 106.09 | 11.53 | 536 | 54941 | 255367 | 53038222 |
Arteriospasm coronary | 104.82 | 11.53 | 59 | 55418 | 3718 | 53289871 |
Gastrointestinal toxicity | 104.77 | 11.53 | 64 | 55413 | 4698 | 53288891 |
Enteritis | 103.09 | 11.53 | 75 | 55402 | 7371 | 53286218 |
Product dose omission issue | 100.20 | 11.53 | 37 | 55440 | 191583 | 53102006 |
Focal nodular hyperplasia | 85.96 | 11.53 | 29 | 55448 | 511 | 53293078 |
Drug clearance decreased | 83.92 | 11.53 | 35 | 55442 | 1131 | 53292458 |
Peripheral swelling | 82.06 | 11.53 | 57 | 55420 | 206051 | 53087538 |
Gastrointestinal perforation | 80.51 | 11.53 | 48 | 55429 | 3371 | 53290218 |
Proteinuria | 77.80 | 11.53 | 95 | 55382 | 17973 | 53275616 |
Dehydration | 77.03 | 11.53 | 363 | 55114 | 168047 | 53125542 |
Adenocarcinoma of colon | 76.93 | 11.53 | 41 | 55436 | 2318 | 53291271 |
Glossodynia | 75.83 | 11.53 | 8 | 55469 | 100283 | 53193306 |
Laryngospasm | 73.61 | 11.53 | 43 | 55434 | 2907 | 53290682 |
Myelosuppression | 73.12 | 11.53 | 78 | 55399 | 12750 | 53280839 |
Hypomagnesaemia | 72.49 | 11.53 | 108 | 55369 | 24703 | 53268886 |
Leukoencephalopathy | 71.19 | 11.53 | 48 | 55429 | 4176 | 53289413 |
Hyperammonaemic encephalopathy | 70.72 | 11.53 | 37 | 55440 | 2014 | 53291575 |
Dysarthria | 70.21 | 11.53 | 140 | 55337 | 40428 | 53253161 |
Non-cirrhotic portal hypertension | 69.78 | 11.53 | 18 | 55459 | 115 | 53293474 |
Arthropathy | 69.52 | 11.53 | 30 | 55447 | 141423 | 53152166 |
Portal hypertension | 69.22 | 11.53 | 45 | 55432 | 3683 | 53289906 |
General physical health deterioration | 68.85 | 11.53 | 319 | 55158 | 146623 | 53146966 |
Peripheral sensory neuropathy | 66.57 | 11.53 | 57 | 55420 | 7091 | 53286498 |
Metastases to lung | 66.42 | 11.53 | 71 | 55406 | 11633 | 53281956 |
Swelling | 63.52 | 11.53 | 63 | 55414 | 191042 | 53102547 |
Hyperammonaemia | 62.65 | 11.53 | 48 | 55429 | 5101 | 53288488 |
Fall | 62.05 | 11.53 | 180 | 55297 | 358260 | 52935329 |
Pyrexia | 60.17 | 11.53 | 662 | 54815 | 402531 | 52891058 |
Paronychia | 59.63 | 11.53 | 46 | 55431 | 4938 | 53288651 |
Colon cancer metastatic | 58.95 | 11.53 | 28 | 55449 | 1237 | 53292352 |
Insomnia | 58.43 | 11.53 | 65 | 55412 | 187007 | 53106582 |
Intestinal perforation | 57.58 | 11.53 | 65 | 55412 | 11315 | 53282274 |
Hypertension | 57.32 | 11.53 | 416 | 55061 | 225015 | 53068574 |
Human bocavirus infection | 56.89 | 11.53 | 19 | 55458 | 324 | 53293265 |
Secondary immunodeficiency | 56.03 | 11.53 | 26 | 55451 | 1089 | 53292500 |
Drug hypersensitivity | 54.52 | 11.53 | 122 | 55355 | 265120 | 53028469 |
Pneumatosis intestinalis | 54.10 | 11.53 | 32 | 55445 | 2214 | 53291375 |
Hospitalisation | 52.83 | 11.53 | 6 | 55471 | 71006 | 53222583 |
Splenomegaly | 51.76 | 11.53 | 59 | 55418 | 10380 | 53283209 |
Ileus | 50.88 | 11.53 | 70 | 55407 | 14885 | 53278704 |
Pain | 50.87 | 11.53 | 381 | 55096 | 588017 | 52705572 |
Drug abuse | 50.12 | 11.53 | 5 | 55472 | 65521 | 53228068 |
Hand deformity | 48.51 | 11.53 | 14 | 55463 | 84835 | 53208754 |
Suicide attempt | 48.51 | 11.53 | 3 | 55474 | 58165 | 53235424 |
Loss of employment | 48.28 | 11.53 | 26 | 55451 | 1501 | 53292088 |
Synovitis | 48.25 | 11.53 | 26 | 55451 | 107867 | 53185722 |
Drug ineffective | 48.16 | 11.53 | 582 | 54895 | 816663 | 52476926 |
Neoplasm progression | 47.91 | 11.53 | 100 | 55377 | 29819 | 53263770 |
Hypokalaemia | 47.76 | 11.53 | 213 | 55264 | 96304 | 53197285 |
Abdominal discomfort | 46.79 | 11.53 | 100 | 55377 | 220962 | 53072627 |
Depression | 42.88 | 11.53 | 78 | 55399 | 182974 | 53110615 |
Trichomegaly | 42.85 | 11.53 | 10 | 55467 | 39 | 53293550 |
Metastases to meninges | 42.63 | 11.53 | 27 | 55450 | 2112 | 53291477 |
Gene mutation | 41.00 | 11.53 | 22 | 55455 | 1261 | 53292328 |
Asthma | 40.92 | 11.53 | 32 | 55445 | 108940 | 53184649 |
Ascites | 40.05 | 11.53 | 111 | 55366 | 39624 | 53253965 |
Hepatic enzyme increased | 39.22 | 11.53 | 44 | 55433 | 126151 | 53167438 |
Enterobacter infection | 39.07 | 11.53 | 25 | 55452 | 1991 | 53291598 |
Cystitis radiation | 39.02 | 11.53 | 10 | 55467 | 62 | 53293527 |
Joint swelling | 38.98 | 11.53 | 120 | 55357 | 234518 | 53059071 |
Cholangitis | 38.79 | 11.53 | 36 | 55441 | 4977 | 53288612 |
Steatohepatitis | 38.48 | 11.53 | 16 | 55461 | 513 | 53293076 |
Stress cardiomyopathy | 38.46 | 11.53 | 46 | 55431 | 8516 | 53285073 |
Venous pressure jugular decreased | 38.38 | 11.53 | 9 | 55468 | 36 | 53293553 |
Contraindicated product administered | 38.23 | 11.53 | 51 | 55426 | 135578 | 53158011 |
Atypical haemolytic uraemic syndrome | 38.13 | 11.53 | 16 | 55461 | 525 | 53293064 |
Pericarditis | 37.99 | 11.53 | 10 | 55467 | 64396 | 53229193 |
Sepsis | 37.62 | 11.53 | 271 | 55206 | 146158 | 53147431 |
Mucosal toxicity | 37.50 | 11.53 | 14 | 55463 | 335 | 53293254 |
Bladder tamponade | 37.26 | 11.53 | 10 | 55467 | 76 | 53293513 |
Short-bowel syndrome | 37.10 | 11.53 | 15 | 55462 | 447 | 53293142 |
Dizziness | 37.07 | 11.53 | 231 | 55246 | 372028 | 52921561 |
Neoplasm recurrence | 36.91 | 11.53 | 26 | 55451 | 2428 | 53291161 |
Wound | 36.82 | 11.53 | 25 | 55452 | 91532 | 53202057 |
Device related infection | 36.30 | 11.53 | 76 | 55401 | 22710 | 53270879 |
Injury | 36.22 | 11.53 | 5 | 55472 | 50966 | 53242623 |
Therapy partial responder | 36.05 | 11.53 | 38 | 55439 | 6125 | 53287464 |
Neuromyotonia | 35.66 | 11.53 | 9 | 55468 | 52 | 53293537 |
Hepatocellular injury | 35.56 | 11.53 | 89 | 55388 | 29897 | 53263692 |
Pain in extremity | 35.51 | 11.53 | 164 | 55313 | 284886 | 53008703 |
Factor VII deficiency | 35.41 | 11.53 | 8 | 55469 | 26 | 53293563 |
Neutrophil count decreased | 35.38 | 11.53 | 122 | 55355 | 48976 | 53244613 |
Gastroenteritis norovirus | 35.28 | 11.53 | 22 | 55455 | 1675 | 53291914 |
Lower respiratory tract infection | 35.07 | 11.53 | 26 | 55451 | 90955 | 53202634 |
Female genital tract fistula | 35.05 | 11.53 | 31 | 55446 | 4027 | 53289562 |
Venous thrombosis | 34.97 | 11.53 | 34 | 55443 | 4980 | 53288609 |
Embolism | 34.84 | 11.53 | 41 | 55436 | 7462 | 53286127 |
Chills | 34.82 | 11.53 | 207 | 55270 | 104641 | 53188948 |
Leukoerythroblastosis | 34.53 | 11.53 | 12 | 55465 | 232 | 53293357 |
Irritable bowel syndrome | 34.24 | 11.53 | 3 | 55474 | 43629 | 53249960 |
Cardiotoxicity | 34.08 | 11.53 | 40 | 55437 | 7259 | 53286330 |
Colorectal cancer | 33.97 | 11.53 | 20 | 55457 | 1372 | 53292217 |
Weight increased | 33.70 | 11.53 | 105 | 55372 | 204462 | 53089127 |
Vena cava thrombosis | 33.67 | 11.53 | 24 | 55453 | 2284 | 53291305 |
Discomfort | 33.42 | 11.53 | 30 | 55447 | 95442 | 53198147 |
Immune thrombocytopenia | 33.35 | 11.53 | 45 | 55432 | 9393 | 53284196 |
Aortic thrombosis | 32.85 | 11.53 | 18 | 55459 | 1076 | 53292513 |
Off label use | 32.75 | 11.53 | 680 | 54797 | 471532 | 52822057 |
Large intestine perforation | 32.67 | 11.53 | 41 | 55436 | 7973 | 53285616 |
Sinusitis | 32.62 | 11.53 | 80 | 55397 | 168484 | 53125105 |
Thrombocytopenic purpura | 32.53 | 11.53 | 19 | 55458 | 1284 | 53292305 |
Herpes simplex | 32.24 | 11.53 | 40 | 55437 | 7689 | 53285900 |
Epistaxis | 32.01 | 11.53 | 149 | 55328 | 68561 | 53225028 |
Carcinoembryonic antigen increased | 31.90 | 11.53 | 20 | 55457 | 1537 | 53292052 |
Interstitial lung disease | 31.76 | 11.53 | 133 | 55344 | 58489 | 53235100 |
Blood cholesterol increased | 31.69 | 11.53 | 8 | 55469 | 52981 | 53240608 |
Septic shock | 31.27 | 11.53 | 138 | 55339 | 62091 | 53231498 |
Plasma cell myeloma | 31.11 | 11.53 | 6 | 55471 | 47868 | 53245721 |
Nicotinic acid deficiency | 30.89 | 11.53 | 8 | 55469 | 52 | 53293537 |
Hypersensitivity vasculitis | 30.75 | 11.53 | 30 | 55447 | 4413 | 53289176 |
Intestinal obstruction | 30.67 | 11.53 | 82 | 55395 | 28659 | 53264930 |
Arthralgia | 30.64 | 11.53 | 301 | 55176 | 439482 | 52854107 |
Injection site pain | 30.59 | 11.53 | 44 | 55433 | 113347 | 53180242 |
Haemolytic anaemia | 29.86 | 11.53 | 45 | 55432 | 10394 | 53283195 |
Psoriasis | 29.73 | 11.53 | 28 | 55449 | 87061 | 53206528 |
Sleep disorder | 29.69 | 11.53 | 12 | 55465 | 58858 | 53234731 |
Cholinergic syndrome | 28.91 | 11.53 | 12 | 55465 | 383 | 53293206 |
Tumour lysis syndrome | 28.52 | 11.53 | 38 | 55439 | 7836 | 53285753 |
Chronic obstructive pulmonary disease | 28.36 | 11.53 | 14 | 55463 | 61059 | 53232530 |
Rash pustular | 28.20 | 11.53 | 36 | 55441 | 7120 | 53286469 |
Suicidal ideation | 27.91 | 11.53 | 14 | 55463 | 60497 | 53233092 |
Rheumatoid arthritis | 27.87 | 11.53 | 202 | 55275 | 314329 | 52979260 |
Electrocardiogram QT prolonged | 27.63 | 11.53 | 12 | 55465 | 56391 | 53237198 |
Fluid retention | 27.58 | 11.53 | 11 | 55466 | 54390 | 53239199 |
Wrong technique in product usage process | 27.52 | 11.53 | 14 | 55463 | 60018 | 53233571 |
Anastomotic leak | 27.15 | 11.53 | 12 | 55465 | 448 | 53293141 |
Small intestinal obstruction | 27.09 | 11.53 | 57 | 55420 | 17090 | 53276499 |
Myelodysplastic syndrome | 27.04 | 11.53 | 56 | 55421 | 16604 | 53276985 |
Nasal septum perforation | 26.66 | 11.53 | 14 | 55463 | 768 | 53292821 |
Headache | 26.50 | 11.53 | 396 | 55081 | 536425 | 52757164 |
Superior vena cava syndrome | 26.21 | 11.53 | 13 | 55464 | 632 | 53292957 |
Memory impairment | 25.84 | 11.53 | 30 | 55447 | 84727 | 53208862 |
Metastases to lymph nodes | 25.57 | 11.53 | 35 | 55442 | 7405 | 53286184 |
Catabolic state | 25.55 | 11.53 | 7 | 55470 | 58 | 53293531 |
Ocular toxicity | 25.48 | 11.53 | 12 | 55465 | 520 | 53293069 |
Aortic intramural haematoma | 25.44 | 11.53 | 7 | 55470 | 59 | 53293530 |
Peritonitis | 25.32 | 11.53 | 64 | 55413 | 21623 | 53271966 |
Contusion | 25.19 | 11.53 | 48 | 55429 | 110684 | 53182905 |
Helicobacter infection | 25.16 | 11.53 | 5 | 55472 | 39064 | 53254525 |
Encapsulating peritoneal sclerosis | 25.16 | 11.53 | 11 | 55466 | 400 | 53293189 |
Cardiomyopathy | 24.92 | 11.53 | 55 | 55422 | 17033 | 53276556 |
Gait disturbance | 24.44 | 11.53 | 84 | 55393 | 158758 | 53134831 |
Myalgia | 23.79 | 11.53 | 66 | 55411 | 133425 | 53160164 |
Meningitis streptococcal | 23.76 | 11.53 | 8 | 55469 | 140 | 53293449 |
Duodenal ulcer perforation | 23.74 | 11.53 | 4 | 55473 | 35179 | 53258410 |
Hemiparesis | 23.66 | 11.53 | 62 | 55415 | 21413 | 53272176 |
ECG signs of myocardial ischaemia | 23.61 | 11.53 | 7 | 55470 | 79 | 53293510 |
Myeloid leukaemia | 23.53 | 11.53 | 10 | 55467 | 339 | 53293250 |
Throat tightness | 23.32 | 11.53 | 63 | 55414 | 22153 | 53271436 |
Large intestinal obstruction | 23.06 | 11.53 | 18 | 55459 | 1965 | 53291624 |
Paraesthesia | 23.05 | 11.53 | 218 | 55259 | 127297 | 53166292 |
Rhinovirus infection | 22.91 | 11.53 | 24 | 55453 | 3841 | 53289748 |
Migraine | 22.90 | 11.53 | 30 | 55447 | 80387 | 53213202 |
Jugular vein thrombosis | 22.86 | 11.53 | 21 | 55456 | 2865 | 53290724 |
Neutropenic colitis | 22.78 | 11.53 | 20 | 55457 | 2573 | 53291016 |
Clostridium difficile colitis | 22.74 | 11.53 | 58 | 55419 | 19707 | 53273882 |
Feeling abnormal | 22.58 | 11.53 | 69 | 55408 | 135232 | 53158357 |
Respiratory symptom | 22.41 | 11.53 | 20 | 55457 | 2629 | 53290960 |
Second primary malignancy | 22.21 | 11.53 | 32 | 55445 | 7100 | 53286489 |
Mobility decreased | 22.18 | 11.53 | 28 | 55449 | 76243 | 53217346 |
Portal vein dilatation | 21.96 | 11.53 | 5 | 55472 | 17 | 53293572 |
K-ras gene mutation | 21.96 | 11.53 | 5 | 55472 | 17 | 53293572 |
Encephalopathy | 21.92 | 11.53 | 86 | 55391 | 36722 | 53256867 |
Inferior vena cava stenosis | 21.74 | 11.53 | 5 | 55472 | 18 | 53293571 |
Anxiety | 21.70 | 11.53 | 118 | 55359 | 196586 | 53097003 |
Tumour perforation | 21.55 | 11.53 | 7 | 55470 | 109 | 53293480 |
Acute promyelocytic leukaemia | 21.53 | 11.53 | 13 | 55464 | 934 | 53292655 |
Gastrointestinal stoma complication | 21.39 | 11.53 | 16 | 55461 | 1640 | 53291949 |
Venoocclusive liver disease | 21.25 | 11.53 | 25 | 55452 | 4547 | 53289042 |
Abortion spontaneous | 21.19 | 11.53 | 11 | 55466 | 46624 | 53246965 |
Subileus | 20.93 | 11.53 | 21 | 55456 | 3195 | 53290394 |
Multiple-drug resistance | 20.83 | 11.53 | 21 | 55456 | 3214 | 53290375 |
Biliary tract infection | 20.68 | 11.53 | 10 | 55467 | 460 | 53293129 |
Hypertrichosis | 20.64 | 11.53 | 13 | 55464 | 1007 | 53292582 |
Intentional product misuse | 20.51 | 11.53 | 13 | 55464 | 49379 | 53244210 |
Cholestasis | 20.40 | 11.53 | 71 | 55406 | 28624 | 53264965 |
Overdose | 20.15 | 11.53 | 52 | 55425 | 107684 | 53185905 |
Crystal nephropathy | 20.04 | 11.53 | 12 | 55465 | 849 | 53292740 |
Proctalgia | 19.86 | 11.53 | 26 | 55451 | 5270 | 53288319 |
No adverse event | 19.80 | 11.53 | 8 | 55469 | 39257 | 53254332 |
Cutaneous tuberculosis | 19.78 | 11.53 | 7 | 55470 | 143 | 53293446 |
Productive cough | 19.64 | 11.53 | 18 | 55459 | 56711 | 53236878 |
Hypocapnia | 19.53 | 11.53 | 9 | 55468 | 371 | 53293218 |
Drug withdrawal syndrome | 19.33 | 11.53 | 3 | 55474 | 28019 | 53265570 |
Human herpesvirus 6 infection | 19.25 | 11.53 | 18 | 55459 | 2512 | 53291077 |
Depilation | 19.09 | 11.53 | 4 | 55473 | 8 | 53293581 |
Rectal cancer recurrent | 18.99 | 11.53 | 5 | 55472 | 35 | 53293554 |
Petechiae | 18.96 | 11.53 | 43 | 55434 | 13562 | 53280027 |
Pruritus | 18.83 | 11.53 | 205 | 55272 | 293627 | 52999962 |
Portal shunt | 18.77 | 11.53 | 4 | 55473 | 9 | 53293580 |
Deep vein thrombosis | 18.77 | 11.53 | 149 | 55328 | 82764 | 53210825 |
Venous thrombosis limb | 18.76 | 11.53 | 19 | 55458 | 2924 | 53290665 |
Red cell fragmentation syndrome | 18.75 | 11.53 | 5 | 55472 | 37 | 53293552 |
Hallucination | 18.74 | 11.53 | 17 | 55460 | 53821 | 53239768 |
Occult blood | 18.58 | 11.53 | 13 | 55464 | 1201 | 53292388 |
Multiple organ dysfunction syndrome | 18.52 | 11.53 | 110 | 55367 | 55567 | 53238022 |
Soft tissue necrosis | 18.49 | 11.53 | 9 | 55468 | 420 | 53293169 |
Upper respiratory tract infection | 18.44 | 11.53 | 27 | 55450 | 69070 | 53224519 |
Pneumothorax | 18.35 | 11.53 | 46 | 55431 | 15461 | 53278128 |
Subacute cutaneous lupus erythematosus | 18.31 | 11.53 | 17 | 55460 | 2351 | 53291238 |
Tumour necrosis | 18.29 | 11.53 | 11 | 55466 | 785 | 53292804 |
Metastases to peritoneum | 18.27 | 11.53 | 19 | 55458 | 3016 | 53290573 |
Ovarian fibroma | 18.26 | 11.53 | 6 | 55471 | 97 | 53293492 |
Vitiligo | 18.25 | 11.53 | 13 | 55464 | 1236 | 53292353 |
Coronary artery disease | 18.24 | 11.53 | 6 | 55471 | 33431 | 53260158 |
Blood pressure fluctuation | 18.07 | 11.53 | 79 | 55398 | 35391 | 53258198 |
Unevaluable event | 17.99 | 11.53 | 15 | 55462 | 49483 | 53244106 |
Endometrial dysplasia | 17.95 | 11.53 | 4 | 55473 | 12 | 53293577 |
Maternal exposure during pregnancy | 17.92 | 11.53 | 92 | 55385 | 155547 | 53138042 |
Irritability | 17.88 | 11.53 | 5 | 55472 | 30948 | 53262641 |
Hyperbilirubinaemia | 17.72 | 11.53 | 37 | 55440 | 11032 | 53282557 |
Evans syndrome | 17.59 | 11.53 | 7 | 55470 | 200 | 53293389 |
Pneumonia | 17.51 | 11.53 | 308 | 55169 | 406861 | 52886728 |
Adverse drug reaction | 17.42 | 11.53 | 18 | 55459 | 53607 | 53239982 |
Amnesia | 17.37 | 11.53 | 13 | 55464 | 45275 | 53248314 |
Somnolence | 17.21 | 11.53 | 103 | 55374 | 167631 | 53125958 |
Condition aggravated | 17.21 | 11.53 | 212 | 55265 | 296922 | 52996667 |
Haemolytic uraemic syndrome | 17.18 | 11.53 | 17 | 55460 | 2544 | 53291045 |
Peripheral sensorimotor neuropathy | 17.13 | 11.53 | 13 | 55464 | 1362 | 53292227 |
Pelvic fluid collection | 17.10 | 11.53 | 11 | 55466 | 884 | 53292705 |
Hip arthroplasty | 17.06 | 11.53 | 4 | 55473 | 27858 | 53265731 |
Mouth ulceration | 17.04 | 11.53 | 68 | 55409 | 29258 | 53264331 |
Reticulocytosis | 16.94 | 11.53 | 6 | 55471 | 123 | 53293466 |
Cardiomyopathy acute | 16.93 | 11.53 | 7 | 55470 | 221 | 53293368 |
Cardiac arrest | 16.92 | 11.53 | 46 | 55431 | 93621 | 53199968 |
Gastroenteropancreatic neuroendocrine tumour disease | 16.90 | 11.53 | 5 | 55472 | 56 | 53293533 |
Asthenia | 16.83 | 11.53 | 472 | 55005 | 343118 | 52950471 |
Exposure during pregnancy | 16.63 | 11.53 | 70 | 55407 | 124790 | 53168799 |
Product quality issue | 16.43 | 11.53 | 9 | 55468 | 37014 | 53256575 |
Depressed mood | 16.38 | 11.53 | 9 | 55468 | 36955 | 53256634 |
Dysaesthesia pharynx | 16.17 | 11.53 | 6 | 55471 | 141 | 53293448 |
Loss of personal independence in daily activities | 16.10 | 11.53 | 30 | 55447 | 69785 | 53223804 |
Hepatitis toxic | 15.99 | 11.53 | 18 | 55459 | 3123 | 53290466 |
Bradycardia | 15.98 | 11.53 | 31 | 55446 | 71025 | 53222564 |
Intracranial pressure increased | 15.96 | 11.53 | 22 | 55455 | 4684 | 53288905 |
Psychotic disorder | 15.96 | 11.53 | 3 | 55474 | 24382 | 53269207 |
Pelvic abscess | 15.86 | 11.53 | 13 | 55464 | 1523 | 53292066 |
Emotional distress | 15.63 | 11.53 | 7 | 55470 | 32310 | 53261279 |
Dysphagia | 15.60 | 11.53 | 145 | 55332 | 84252 | 53209337 |
Agitation | 15.56 | 11.53 | 23 | 55454 | 58603 | 53234986 |
Liver abscess | 15.54 | 11.53 | 17 | 55460 | 2858 | 53290731 |
Pneumothorax spontaneous | 15.53 | 11.53 | 9 | 55468 | 599 | 53292990 |
Percussion test abnormal | 15.53 | 11.53 | 3 | 55474 | 3 | 53293586 |
Bone pain | 15.40 | 11.53 | 18 | 55459 | 50704 | 53242885 |
Treatment failure | 15.30 | 11.53 | 75 | 55402 | 128328 | 53165261 |
Rectal perforation | 15.18 | 11.53 | 8 | 55469 | 442 | 53293147 |
Folliculitis | 15.13 | 11.53 | 7 | 55470 | 31702 | 53261887 |
Colitis | 15.06 | 11.53 | 84 | 55393 | 41468 | 53252121 |
Sedation | 15.04 | 11.53 | 6 | 55471 | 29669 | 53263920 |
Hydronephrosis | 15.03 | 11.53 | 31 | 55446 | 9165 | 53284424 |
Gastrointestinal anastomotic leak | 14.99 | 11.53 | 6 | 55471 | 174 | 53293415 |
COVID-19 | 14.92 | 11.53 | 10 | 55467 | 36878 | 53256711 |
Varices oesophageal | 14.89 | 11.53 | 17 | 55460 | 2995 | 53290594 |
Toxic encephalopathy | 14.79 | 11.53 | 24 | 55453 | 5903 | 53287686 |
Product prescribing error | 14.72 | 11.53 | 3 | 55474 | 23028 | 53270561 |
Product use in unapproved indication | 14.70 | 11.53 | 180 | 55297 | 112109 | 53181480 |
Nodular regenerative hyperplasia | 14.68 | 11.53 | 7 | 55470 | 312 | 53293277 |
Rhinocerebral mucormycosis | 14.65 | 11.53 | 6 | 55471 | 185 | 53293404 |
Product intolerance | 14.62 | 11.53 | 4 | 55473 | 33 | 53293556 |
Hepatic vein stenosis | 14.51 | 11.53 | 4 | 55473 | 34 | 53293555 |
Haemolysis | 14.47 | 11.53 | 25 | 55452 | 6471 | 53287118 |
Blood creatine phosphokinase increased | 14.46 | 11.53 | 6 | 55471 | 28979 | 53264610 |
Metastasis | 14.40 | 11.53 | 21 | 55456 | 4710 | 53288879 |
Optic disc hyperaemia | 14.32 | 11.53 | 3 | 55474 | 6 | 53293583 |
Periportal sinus dilatation | 14.32 | 11.53 | 3 | 55474 | 6 | 53293583 |
Laryngeal injury | 14.32 | 11.53 | 3 | 55474 | 6 | 53293583 |
Type II hypersensitivity | 14.32 | 11.53 | 3 | 55474 | 6 | 53293583 |
Pelvic mass | 14.25 | 11.53 | 11 | 55466 | 1182 | 53292407 |
Overgrowth fungal | 14.14 | 11.53 | 5 | 55472 | 102 | 53293487 |
Procedural site reaction | 14.08 | 11.53 | 7 | 55470 | 342 | 53293247 |
Blister | 13.98 | 11.53 | 39 | 55438 | 78714 | 53214875 |
Tubular breast carcinoma | 13.75 | 11.53 | 4 | 55473 | 42 | 53293547 |
Knee arthroplasty | 13.72 | 11.53 | 9 | 55468 | 33560 | 53260029 |
Chemotherapeutic drug level above therapeutic | 13.67 | 11.53 | 4 | 55473 | 43 | 53293546 |
Peritoneal disorder | 13.64 | 11.53 | 8 | 55469 | 545 | 53293044 |
Escherichia bacteraemia | 13.60 | 11.53 | 17 | 55460 | 3291 | 53290298 |
Fluid overload | 13.51 | 11.53 | 6 | 55471 | 27825 | 53265764 |
Acquired gene mutation | 13.50 | 11.53 | 9 | 55468 | 768 | 53292821 |
Optic nerve disorder | 13.50 | 11.53 | 9 | 55468 | 768 | 53292821 |
Cough | 13.50 | 11.53 | 187 | 55290 | 256706 | 53036883 |
Cognitive disorder | 13.48 | 11.53 | 16 | 55461 | 44762 | 53248827 |
Head injury | 13.46 | 11.53 | 5 | 55472 | 25828 | 53267761 |
Gait inability | 13.45 | 11.53 | 12 | 55465 | 38299 | 53255290 |
Disease recurrence | 13.34 | 11.53 | 50 | 55427 | 20896 | 53272693 |
Colon cancer recurrent | 13.27 | 11.53 | 4 | 55473 | 48 | 53293541 |
Panic attack | 13.26 | 11.53 | 3 | 55474 | 21415 | 53272174 |
Duodenal obstruction | 13.19 | 11.53 | 6 | 55471 | 240 | 53293349 |
Balance disorder | 13.18 | 11.53 | 36 | 55441 | 73171 | 53220418 |
Hepatic lesion | 13.18 | 11.53 | 19 | 55458 | 4218 | 53289371 |
Extravasation | 13.16 | 11.53 | 14 | 55463 | 2280 | 53291309 |
Tumour rupture | 13.15 | 11.53 | 5 | 55472 | 126 | 53293463 |
Cachexia | 13.01 | 11.53 | 21 | 55456 | 5143 | 53288446 |
Acute myeloid leukaemia | 13.01 | 11.53 | 43 | 55434 | 16889 | 53276700 |
Fibromyalgia | 13.00 | 11.53 | 16 | 55461 | 44059 | 53249530 |
Psychiatric decompensation | 12.97 | 11.53 | 11 | 55466 | 1351 | 53292238 |
Bronchitis | 12.96 | 11.53 | 66 | 55411 | 111833 | 53181756 |
Neutropenic sepsis | 12.90 | 11.53 | 39 | 55438 | 14610 | 53278979 |
Benign hydatidiform mole | 12.90 | 11.53 | 5 | 55472 | 133 | 53293456 |
Drug eruption | 12.84 | 11.53 | 5 | 55472 | 25089 | 53268500 |
Cytopenia | 12.79 | 11.53 | 29 | 55448 | 9141 | 53284448 |
Accessory spleen | 12.79 | 11.53 | 3 | 55474 | 12 | 53293577 |
Impaired healing | 12.78 | 11.53 | 30 | 55447 | 64175 | 53229414 |
Acute kidney injury | 12.76 | 11.53 | 350 | 55127 | 253518 | 53040071 |
Febrile bone marrow aplasia | 12.66 | 11.53 | 25 | 55452 | 7164 | 53286425 |
Confusional state | 12.63 | 11.53 | 135 | 55342 | 194086 | 53099503 |
Diabetes mellitus | 12.57 | 11.53 | 23 | 55454 | 53876 | 53239713 |
Vaginal fistula | 12.54 | 11.53 | 7 | 55470 | 434 | 53293155 |
Hypertransaminasaemia | 12.48 | 11.53 | 18 | 55459 | 3998 | 53289591 |
Granulomatous lymphadenitis | 12.46 | 11.53 | 5 | 55472 | 146 | 53293443 |
Tubal rupture | 12.42 | 11.53 | 3 | 55474 | 14 | 53293575 |
Peripheral nerve injury | 12.39 | 11.53 | 7 | 55470 | 444 | 53293145 |
Cardiac failure congestive | 12.35 | 11.53 | 52 | 55425 | 92705 | 53200884 |
Neuroborreliosis | 12.33 | 11.53 | 4 | 55473 | 62 | 53293527 |
Hepatic steatosis | 12.26 | 11.53 | 57 | 55420 | 26202 | 53267387 |
Anaemia of malignant disease | 12.25 | 11.53 | 7 | 55470 | 454 | 53293135 |
Eczema asteatotic | 12.21 | 11.53 | 6 | 55471 | 286 | 53293303 |
Cerebrovascular accident | 12.20 | 11.53 | 62 | 55415 | 105112 | 53188477 |
Neuroendocrine carcinoma of the skin | 12.11 | 11.53 | 7 | 55470 | 464 | 53293125 |
Haematuria | 12.08 | 11.53 | 60 | 55417 | 28329 | 53265260 |
Treatment noncompliance | 12.02 | 11.53 | 10 | 55467 | 33025 | 53260564 |
Hemianaesthesia | 12.00 | 11.53 | 7 | 55470 | 472 | 53293117 |
Ovarian cystectomy | 11.89 | 11.53 | 5 | 55472 | 165 | 53293424 |
Gastrooesophageal reflux disease | 11.85 | 11.53 | 45 | 55432 | 82618 | 53210971 |
Enterocolitis | 11.79 | 11.53 | 24 | 55453 | 7028 | 53286561 |
Hypocalcaemia | 11.78 | 11.53 | 61 | 55416 | 29276 | 53264313 |
Gastrointestinal necrosis | 11.76 | 11.53 | 15 | 55462 | 2965 | 53290624 |
Metastases to bone marrow | 11.69 | 11.53 | 6 | 55471 | 314 | 53293275 |
Portal vein thrombosis | 11.65 | 11.53 | 14 | 55463 | 2605 | 53290984 |
Acute lymphocytic leukaemia recurrent | 11.64 | 11.53 | 13 | 55464 | 2235 | 53291354 |
Visual acuity reduced transiently | 11.61 | 11.53 | 5 | 55472 | 175 | 53293414 |
Device dislocation | 11.59 | 11.53 | 5 | 55472 | 23592 | 53269997 |
Respiratory disorder | 11.59 | 11.53 | 11 | 55466 | 34086 | 53259503 |
Mitral valve disease | 11.59 | 11.53 | 13 | 55464 | 2247 | 53291342 |
Organising pneumonia | 11.58 | 11.53 | 20 | 55457 | 5176 | 53288413 |
Finger deformity | 11.55 | 11.53 | 21 | 55456 | 5656 | 53287933 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neutropenia | 947.22 | 12.73 | 1274 | 62558 | 140901 | 32308793 |
Neuropathy peripheral | 576.60 | 12.73 | 732 | 63100 | 76250 | 32373444 |
Diarrhoea | 539.10 | 12.73 | 1751 | 62081 | 363051 | 32086643 |
Skin toxicity | 515.09 | 12.73 | 215 | 63617 | 3591 | 32446103 |
Mucosal inflammation | 463.89 | 12.73 | 440 | 63392 | 32994 | 32416700 |
Disease progression | 396.12 | 12.73 | 653 | 63179 | 86209 | 32363485 |
Neurotoxicity | 361.48 | 12.73 | 272 | 63560 | 14798 | 32434896 |
Metastases to liver | 347.57 | 12.73 | 250 | 63582 | 12682 | 32437012 |
Dermatitis acneiform | 337.96 | 12.73 | 186 | 63646 | 5859 | 32443835 |
Stomatitis | 307.76 | 12.73 | 387 | 63445 | 39842 | 32409852 |
Thrombocytopenia | 306.93 | 12.73 | 805 | 63027 | 147494 | 32302200 |
Palmar-plantar erythrodysaesthesia syndrome | 305.91 | 12.73 | 251 | 63581 | 15498 | 32434196 |
Colorectal cancer metastatic | 269.06 | 12.73 | 96 | 63736 | 1021 | 32448673 |
Arteriospasm coronary | 259.31 | 12.73 | 122 | 63710 | 2738 | 32446956 |
Polyneuropathy | 206.53 | 12.73 | 186 | 63646 | 13029 | 32436665 |
Febrile neutropenia | 158.12 | 12.73 | 555 | 63277 | 119011 | 32330683 |
Proteinuria | 155.52 | 12.73 | 181 | 63651 | 17174 | 32432520 |
Completed suicide | 155.41 | 12.73 | 6 | 63826 | 92511 | 32357183 |
Gastrointestinal toxicity | 150.21 | 12.73 | 77 | 63755 | 2092 | 32447602 |
Leukopenia | 144.55 | 12.73 | 346 | 63486 | 59776 | 32389918 |
Skin reaction | 143.97 | 12.73 | 100 | 63732 | 4792 | 32444902 |
Vomiting | 142.92 | 12.73 | 869 | 62963 | 234688 | 32215006 |
Cardiotoxicity | 133.97 | 12.73 | 96 | 63736 | 4836 | 32444858 |
Product dose omission issue | 130.92 | 12.73 | 22 | 63810 | 102553 | 32347141 |
Nausea | 130.53 | 12.73 | 1074 | 62758 | 319775 | 32129919 |
Portal hypertension | 126.50 | 12.73 | 86 | 63746 | 3978 | 32445716 |
Paronychia | 126.49 | 12.73 | 79 | 63753 | 3158 | 32446536 |
Pyrexia | 123.19 | 12.73 | 1058 | 62774 | 318910 | 32130784 |
Drug ineffective | 122.62 | 12.73 | 368 | 63464 | 383109 | 32066585 |
Abdominal pain | 121.06 | 12.73 | 597 | 63235 | 148932 | 32300762 |
Peripheral sensory neuropathy | 118.51 | 12.73 | 100 | 63732 | 6414 | 32443280 |
Carcinoembryonic antigen increased | 117.87 | 12.73 | 47 | 63785 | 693 | 32449001 |
Metastases to lung | 117.01 | 12.73 | 111 | 63721 | 8306 | 32441388 |
Decreased appetite | 114.19 | 12.73 | 619 | 63213 | 160194 | 32289500 |
Intestinal obstruction | 112.02 | 12.73 | 169 | 63663 | 20629 | 32429065 |
Bone marrow failure | 111.52 | 12.73 | 208 | 63624 | 30196 | 32419498 |
Haematotoxicity | 107.09 | 12.73 | 96 | 63736 | 6680 | 32443014 |
General physical health deterioration | 102.51 | 12.73 | 473 | 63359 | 114786 | 32334908 |
Drug abuse | 100.64 | 12.73 | 18 | 63814 | 80225 | 32369469 |
Cardiac failure congestive | 100.21 | 12.73 | 22 | 63810 | 84830 | 32364864 |
Hyperammonaemic encephalopathy | 97.59 | 12.73 | 57 | 63775 | 2014 | 32447680 |
Chills | 97.57 | 12.73 | 356 | 63476 | 77728 | 32371966 |
Pulmonary embolism | 95.89 | 12.73 | 371 | 63461 | 83288 | 32366406 |
Hyperammonaemia | 93.21 | 12.73 | 84 | 63748 | 5885 | 32443809 |
Colorectal cancer | 93.15 | 12.73 | 57 | 63775 | 2196 | 32447498 |
Plasma cell myeloma | 92.61 | 12.73 | 5 | 63827 | 57609 | 32392085 |
Rash pustular | 89.83 | 12.73 | 78 | 63754 | 5201 | 32444493 |
Alopecia | 87.77 | 12.73 | 151 | 63681 | 20579 | 32429115 |
Rhabdomyolysis | 86.75 | 12.73 | 14 | 63818 | 67251 | 32382443 |
Malignant neoplasm progression | 81.84 | 12.73 | 338 | 63494 | 78158 | 32371536 |
Fall | 81.54 | 12.73 | 164 | 63668 | 196037 | 32253657 |
Neoplasm progression | 80.37 | 12.73 | 141 | 63691 | 19517 | 32430177 |
Focal nodular hyperplasia | 79.80 | 12.73 | 24 | 63808 | 140 | 32449554 |
Gastrointestinal perforation | 79.72 | 12.73 | 64 | 63768 | 3826 | 32445868 |
Drug interaction | 79.54 | 12.73 | 196 | 63636 | 217989 | 32231705 |
Myalgia | 79.49 | 12.73 | 30 | 63802 | 81200 | 32368494 |
Anxiety | 76.36 | 12.73 | 47 | 63785 | 95958 | 32353736 |
Myelosuppression | 74.74 | 12.73 | 103 | 63729 | 11573 | 32438121 |
Therapy partial responder | 74.28 | 12.73 | 68 | 63764 | 4862 | 32444832 |
Ascites | 71.68 | 12.73 | 207 | 63625 | 39984 | 32409710 |
Insomnia | 70.72 | 12.73 | 56 | 63776 | 100292 | 32349402 |
Asthma | 70.27 | 12.73 | 4 | 63828 | 44061 | 32405633 |
Paraesthesia | 69.63 | 12.73 | 264 | 63568 | 58680 | 32391014 |
Interstitial lung disease | 69.40 | 12.73 | 282 | 63550 | 64719 | 32384975 |
Adenocarcinoma of colon | 66.44 | 12.73 | 55 | 63777 | 3434 | 32446260 |
Pneumonia | 66.07 | 12.73 | 418 | 63414 | 354834 | 32094860 |
Death | 64.22 | 12.73 | 464 | 63368 | 382053 | 32067641 |
Somnolence | 63.52 | 12.73 | 66 | 63766 | 103731 | 32345963 |
Dehydration | 63.47 | 12.73 | 452 | 63380 | 128506 | 32321188 |
Headache | 62.64 | 12.73 | 188 | 63644 | 196009 | 32253685 |
Hypomagnesaemia | 62.00 | 12.73 | 123 | 63709 | 18682 | 32431012 |
Arthralgia | 60.84 | 12.73 | 125 | 63707 | 148323 | 32301371 |
Metastases to lymph nodes | 60.79 | 12.73 | 58 | 63774 | 4370 | 32445324 |
Ileus | 60.53 | 12.73 | 112 | 63720 | 16153 | 32433541 |
Enteritis | 57.28 | 12.73 | 71 | 63761 | 7190 | 32442504 |
Hiccups | 56.99 | 12.73 | 83 | 63749 | 9812 | 32439882 |
Weight increased | 56.09 | 12.73 | 49 | 63783 | 83614 | 32366080 |
Metastases to peritoneum | 56.04 | 12.73 | 37 | 63795 | 1629 | 32448065 |
Small intestinal obstruction | 55.67 | 12.73 | 100 | 63732 | 14096 | 32435598 |
Hospitalisation | 55.22 | 12.73 | 14 | 63818 | 48957 | 32400737 |
Aggression | 53.55 | 12.73 | 7 | 63825 | 39382 | 32410312 |
Subclavian vein thrombosis | 53.14 | 12.73 | 29 | 63803 | 897 | 32448797 |
Intentional overdose | 52.87 | 12.73 | 9 | 63823 | 41592 | 32408102 |
Febrile bone marrow aplasia | 52.01 | 12.73 | 73 | 63759 | 8342 | 32441352 |
Device related infection | 51.71 | 12.73 | 111 | 63721 | 17822 | 32431872 |
Bradycardia | 51.59 | 12.73 | 39 | 63793 | 71523 | 32378171 |
Colon cancer metastatic | 51.47 | 12.73 | 36 | 63796 | 1744 | 32447950 |
Subileus | 51.04 | 12.73 | 46 | 63786 | 3222 | 32446472 |
Leukoencephalopathy | 50.96 | 12.73 | 51 | 63781 | 4074 | 32445620 |
Myocardial infarction | 50.49 | 12.73 | 107 | 63725 | 125569 | 32324125 |
Psoriasis | 50.46 | 12.73 | 14 | 63818 | 46109 | 32403585 |
Anastomotic complication | 49.84 | 12.73 | 21 | 63811 | 359 | 32449335 |
Peripheral swelling | 49.59 | 12.73 | 37 | 63795 | 68308 | 32381386 |
Cholangitis | 49.44 | 12.73 | 71 | 63761 | 8287 | 32441407 |
Transdifferentiation of neoplasm | 49.37 | 12.73 | 14 | 63818 | 64 | 32449630 |
Dizziness | 49.15 | 12.73 | 228 | 63604 | 209390 | 32240304 |
Blood glucose increased | 49.06 | 12.73 | 34 | 63798 | 65207 | 32384487 |
Depression | 47.62 | 12.73 | 73 | 63759 | 96987 | 32352707 |
Anastomotic leak | 47.42 | 12.73 | 24 | 63808 | 634 | 32449060 |
Influenza | 46.69 | 12.73 | 16 | 63816 | 45998 | 32403696 |
Epistaxis | 46.48 | 12.73 | 225 | 63607 | 55630 | 32394064 |
Drug clearance decreased | 45.59 | 12.73 | 31 | 63801 | 1434 | 32448260 |
Colon cancer stage III | 44.93 | 12.73 | 16 | 63816 | 169 | 32449525 |
Intestinal perforation | 44.79 | 12.73 | 70 | 63762 | 8805 | 32440889 |
Carbohydrate antigen 19-9 increased | 44.71 | 12.73 | 17 | 63815 | 219 | 32449475 |
Suicidal ideation | 44.68 | 12.73 | 10 | 63822 | 38073 | 32411621 |
Chronic obstructive pulmonary disease | 44.45 | 12.73 | 20 | 63812 | 48733 | 32400961 |
Febrile infection | 44.25 | 12.73 | 36 | 63796 | 2193 | 32447501 |
Proteus infection | 43.69 | 12.73 | 25 | 63807 | 849 | 32448845 |
Tumour lysis syndrome | 43.05 | 12.73 | 91 | 63741 | 14456 | 32435238 |
Injection site pain | 42.34 | 12.73 | 7 | 63825 | 33051 | 32416643 |
Electrocardiogram ST segment elevation | 42.04 | 12.73 | 50 | 63782 | 4850 | 32444844 |
Pain in extremity | 40.79 | 12.73 | 110 | 63722 | 118791 | 32330903 |
Tumour necrosis | 40.68 | 12.73 | 27 | 63805 | 1199 | 32448495 |
Conjunctivitis | 40.17 | 12.73 | 66 | 63766 | 8660 | 32441034 |
Hallucination | 40.12 | 12.73 | 27 | 63805 | 52592 | 32397102 |
Coronary artery disease | 39.96 | 12.73 | 24 | 63808 | 49682 | 32400012 |
Feeling abnormal | 39.75 | 12.73 | 36 | 63796 | 60387 | 32389307 |
Rheumatoid arthritis | 39.48 | 12.73 | 19 | 63813 | 44525 | 32405169 |
Intravascular haemolysis | 39.48 | 12.73 | 19 | 63813 | 449 | 32449245 |
Nicotinic acid deficiency | 39.34 | 12.73 | 12 | 63820 | 74 | 32449620 |
Hypersensitivity | 39.29 | 12.73 | 220 | 63612 | 57538 | 32392156 |
Unevaluable event | 39.04 | 12.73 | 9 | 63823 | 33577 | 32416117 |
Erythema | 38.37 | 12.73 | 287 | 63545 | 82818 | 32366876 |
Necrotising fasciitis | 38.33 | 12.73 | 42 | 63790 | 3727 | 32445967 |
Vena cava thrombosis | 38.02 | 12.73 | 25 | 63807 | 1093 | 32448601 |
Anal fissure | 37.85 | 12.73 | 37 | 63795 | 2872 | 32446822 |
Anal haemorrhage | 37.53 | 12.73 | 32 | 63800 | 2081 | 32447613 |
Cholinergic syndrome | 37.51 | 12.73 | 19 | 63813 | 503 | 32449191 |
Colon cancer recurrent | 37.50 | 12.73 | 13 | 63819 | 126 | 32449568 |
Contusion | 36.90 | 12.73 | 10 | 63822 | 33458 | 32416236 |
Colitis | 36.77 | 12.73 | 148 | 63684 | 33803 | 32415891 |
Acute coronary syndrome | 36.48 | 12.73 | 83 | 63749 | 13858 | 32435836 |
Hypoglycaemia | 36.25 | 12.73 | 32 | 63800 | 54350 | 32395344 |
Overdose | 35.91 | 12.73 | 73 | 63759 | 87004 | 32362690 |
Ileal perforation | 35.80 | 12.73 | 21 | 63811 | 748 | 32448946 |
Intentional product misuse | 35.77 | 12.73 | 13 | 63819 | 36038 | 32413656 |
Small intestinal perforation | 35.60 | 12.73 | 29 | 63803 | 1770 | 32447924 |
Wheezing | 35.42 | 12.73 | 14 | 63818 | 36860 | 32412834 |
Cellulitis | 35.40 | 12.73 | 28 | 63804 | 50202 | 32399492 |
Memory impairment | 34.77 | 12.73 | 18 | 63814 | 40461 | 32409233 |
Pneumatosis intestinalis | 34.59 | 12.73 | 38 | 63794 | 3382 | 32446312 |
Administration site extravasation | 34.32 | 12.73 | 18 | 63814 | 513 | 32449181 |
Treatment noncompliance | 34.31 | 12.73 | 6 | 63826 | 27196 | 32422498 |
Adverse drug reaction | 34.20 | 12.73 | 5 | 63827 | 25856 | 32423838 |
Splenomegaly | 33.33 | 12.73 | 82 | 63750 | 14395 | 32435299 |
Pelvic abscess | 33.09 | 12.73 | 22 | 63810 | 980 | 32448714 |
Enterovesical fistula | 32.84 | 12.73 | 19 | 63813 | 659 | 32449035 |
Confusional state | 32.72 | 12.73 | 157 | 63675 | 142958 | 32306736 |
Recall phenomenon | 32.63 | 12.73 | 18 | 63814 | 569 | 32449125 |
Anaemia of malignant disease | 32.49 | 12.73 | 16 | 63816 | 398 | 32449296 |
Sinusitis | 31.79 | 12.73 | 16 | 63816 | 36544 | 32413150 |
Muscle spasms | 31.69 | 12.73 | 56 | 63776 | 70362 | 32379332 |
Rectal cancer metastatic | 31.27 | 12.73 | 14 | 63818 | 279 | 32449415 |
Rectal adenocarcinoma | 31.11 | 12.73 | 20 | 63812 | 841 | 32448853 |
Fluid retention | 31.09 | 12.73 | 7 | 63825 | 26543 | 32423151 |
Abdominal pain lower | 31.08 | 12.73 | 62 | 63770 | 9451 | 32440243 |
Foetal disorder | 30.61 | 12.73 | 19 | 63813 | 751 | 32448943 |
Hypoalbuminaemia | 30.50 | 12.73 | 70 | 63762 | 11752 | 32437942 |
Neoplasm recurrence | 30.38 | 12.73 | 28 | 63804 | 2019 | 32447675 |
Large intestine perforation | 30.27 | 12.73 | 56 | 63776 | 8074 | 32441620 |
Blood creatine phosphokinase increased | 30.02 | 12.73 | 27 | 63805 | 45449 | 32404245 |
Proctalgia | 29.83 | 12.73 | 41 | 63791 | 4593 | 32445101 |
Oesophagitis | 29.33 | 12.73 | 73 | 63759 | 12908 | 32436786 |
Induration | 29.28 | 12.73 | 20 | 63812 | 932 | 32448762 |
Catheter site thrombosis | 28.68 | 12.73 | 8 | 63824 | 34 | 32449660 |
Pancreatic carcinoma metastatic | 28.61 | 12.73 | 34 | 63798 | 3295 | 32446399 |
Jugular vein thrombosis | 28.58 | 12.73 | 24 | 63808 | 1528 | 32448166 |
Evans syndrome | 28.54 | 12.73 | 13 | 63819 | 270 | 32449424 |
Wrong technique in product usage process | 28.08 | 12.73 | 17 | 63815 | 35042 | 32414652 |
Product prescribing error | 28.05 | 12.73 | 3 | 63829 | 19714 | 32429980 |
Peritoneal neoplasm | 27.96 | 12.73 | 8 | 63824 | 38 | 32449656 |
Injury | 27.85 | 12.73 | 5 | 63827 | 22240 | 32427454 |
Toxic erythema of chemotherapy | 27.70 | 12.73 | 9 | 63823 | 70 | 32449624 |
Product use issue | 27.53 | 12.73 | 38 | 63794 | 52739 | 32396955 |
Pelvic fluid collection | 27.40 | 12.73 | 10 | 63822 | 114 | 32449580 |
Asthenia | 27.18 | 12.73 | 630 | 63202 | 235314 | 32214380 |
Prothrombin level decreased | 26.99 | 12.73 | 21 | 63811 | 1199 | 32448495 |
Circulatory collapse | 26.91 | 12.73 | 97 | 63735 | 21028 | 32428666 |
Influenza like illness | 26.57 | 12.73 | 10 | 63822 | 27130 | 32422564 |
Sleep apnoea syndrome | 26.41 | 12.73 | 3 | 63829 | 18811 | 32430883 |
Disturbance in attention | 26.37 | 12.73 | 7 | 63825 | 23746 | 32425948 |
Rectal perforation | 26.04 | 12.73 | 14 | 63818 | 420 | 32449274 |
Colitis microscopic | 25.94 | 12.73 | 25 | 63807 | 1907 | 32447787 |
Anal erythema | 25.89 | 12.73 | 9 | 63823 | 88 | 32449606 |
Perihepatic abscess | 25.89 | 12.73 | 9 | 63823 | 88 | 32449606 |
Skin fissures | 25.83 | 12.73 | 35 | 63797 | 3868 | 32445826 |
Hyperbilirubinaemia | 25.72 | 12.73 | 85 | 63747 | 17645 | 32432049 |
Electrocardiogram QT prolonged | 25.61 | 12.73 | 24 | 63808 | 39617 | 32410077 |
Peripheral sensorimotor neuropathy | 25.61 | 12.73 | 22 | 63810 | 1445 | 32448249 |
Koebner phenomenon | 25.61 | 12.73 | 8 | 63824 | 54 | 32449640 |
Portal vein thrombosis | 25.50 | 12.73 | 34 | 63798 | 3701 | 32445993 |
Neutropenia neonatal | 25.43 | 12.73 | 16 | 63816 | 648 | 32449046 |
Anaemia | 25.41 | 12.73 | 596 | 63236 | 223028 | 32226666 |
Incorrect dose administered | 25.35 | 12.73 | 19 | 63813 | 35009 | 32414685 |
Cardiac disorder | 25.16 | 12.73 | 27 | 63805 | 41839 | 32407855 |
Perforation | 25.04 | 12.73 | 11 | 63821 | 209 | 32449485 |
Rectal cancer | 24.88 | 12.73 | 27 | 63805 | 2370 | 32447324 |
Chemotherapeutic drug level increased | 24.71 | 12.73 | 11 | 63821 | 216 | 32449478 |
Hypokalaemia | 24.70 | 12.73 | 189 | 63643 | 54905 | 32394789 |
Large intestinal obstruction | 24.68 | 12.73 | 22 | 63810 | 1519 | 32448175 |
Pneumoperitoneum | 24.67 | 12.73 | 24 | 63808 | 1852 | 32447842 |
Superior vena cava syndrome | 24.60 | 12.73 | 15 | 63817 | 574 | 32449120 |
Clostridial infection | 24.36 | 12.73 | 33 | 63799 | 3646 | 32446048 |
Venous thrombosis | 24.34 | 12.73 | 32 | 63800 | 3435 | 32446259 |
Perioral dermatitis | 24.32 | 12.73 | 9 | 63823 | 107 | 32449587 |
Device related thrombosis | 24.27 | 12.73 | 18 | 63814 | 956 | 32448738 |
Enterocutaneous fistula | 24.24 | 12.73 | 17 | 63815 | 827 | 32448867 |
Nephrotic syndrome | 24.23 | 12.73 | 48 | 63784 | 7281 | 32442413 |
Venoocclusive liver disease | 24.06 | 12.73 | 48 | 63784 | 7317 | 32442377 |
Cachexia | 24.03 | 12.73 | 47 | 63785 | 7062 | 32442632 |
International normalised ratio increased | 23.92 | 12.73 | 37 | 63795 | 48998 | 32400696 |
Sedation | 23.55 | 12.73 | 4 | 63828 | 18522 | 32431172 |
Cataract | 23.52 | 12.73 | 9 | 63823 | 24174 | 32425520 |
Acute abdomen | 23.50 | 12.73 | 24 | 63808 | 1964 | 32447730 |
Cerebral vasoconstriction | 23.37 | 12.73 | 11 | 63821 | 247 | 32449447 |
Adenocarcinoma | 23.29 | 12.73 | 23 | 63809 | 1808 | 32447886 |
Interventricular septum rupture | 23.13 | 12.73 | 6 | 63826 | 18 | 32449676 |
Liver abscess | 23.05 | 12.73 | 32 | 63800 | 3619 | 32446075 |
Nail disorder | 23.04 | 12.73 | 23 | 63809 | 1831 | 32447863 |
Productive cough | 22.82 | 12.73 | 20 | 63812 | 34096 | 32415598 |
Cerebrovascular accident | 22.56 | 12.73 | 90 | 63742 | 86230 | 32363464 |
Tumour marker increased | 22.54 | 12.73 | 14 | 63818 | 554 | 32449140 |
Mucosal toxicity | 22.53 | 12.73 | 10 | 63822 | 195 | 32449499 |
Sarcoidosis | 22.46 | 12.73 | 28 | 63804 | 2851 | 32446843 |
Mobility decreased | 22.44 | 12.73 | 14 | 63818 | 28395 | 32421299 |
Type II hypersensitivity | 22.43 | 12.73 | 6 | 63826 | 21 | 32449673 |
Abnormal behaviour | 22.39 | 12.73 | 12 | 63820 | 26454 | 32423240 |
Aplasia | 22.36 | 12.73 | 35 | 63797 | 4407 | 32445287 |
Portal venous gas | 22.23 | 12.73 | 12 | 63820 | 363 | 32449331 |
Trichomegaly | 21.80 | 12.73 | 6 | 63826 | 24 | 32449670 |
Varices oesophageal | 21.50 | 12.73 | 31 | 63801 | 3630 | 32446064 |
Acne | 21.48 | 12.73 | 56 | 63776 | 10186 | 32439508 |
Oral pain | 21.38 | 12.73 | 55 | 63777 | 9923 | 32439771 |
Fluid overload | 21.37 | 12.73 | 6 | 63826 | 19615 | 32430079 |
Cholecystitis chronic | 21.20 | 12.73 | 16 | 63816 | 873 | 32448821 |
Haemorrhage intracranial | 21.17 | 12.73 | 3 | 63829 | 15884 | 32433810 |
Rectal tenesmus | 21.11 | 12.73 | 14 | 63818 | 621 | 32449073 |
Stoma site haemorrhage | 21.10 | 12.73 | 17 | 63815 | 1021 | 32448673 |
Oesophageal haemorrhage | 20.87 | 12.73 | 18 | 63814 | 1189 | 32448505 |
Fistula | 20.72 | 12.73 | 38 | 63794 | 5441 | 32444253 |
Product administration error | 20.71 | 12.73 | 3 | 63829 | 15622 | 32434072 |
Ischiorectal hernia | 20.70 | 12.73 | 5 | 63827 | 10 | 32449684 |
Mouth ulceration | 20.58 | 12.73 | 59 | 63773 | 11342 | 32438352 |
Pulmonary infarction | 20.56 | 12.73 | 18 | 63814 | 1213 | 32448481 |
Haematopoietic stem cell mobilisation | 20.54 | 12.73 | 9 | 63823 | 170 | 32449524 |
Hypertension | 20.50 | 12.73 | 368 | 63464 | 131382 | 32318312 |
Contraindicated product administered | 20.47 | 12.73 | 6 | 63826 | 19070 | 32430624 |
Anastomotic fistula | 20.46 | 12.73 | 7 | 63825 | 65 | 32449629 |
Deep vein thrombosis | 20.43 | 12.73 | 203 | 63629 | 63510 | 32386184 |
Agitation | 20.33 | 12.73 | 52 | 63780 | 57184 | 32392510 |
Cranial nerve disorder | 20.22 | 12.73 | 12 | 63820 | 437 | 32449257 |
Eosinophilia | 20.13 | 12.73 | 12 | 63820 | 24946 | 32424748 |
Abdominal discomfort | 20.12 | 12.73 | 46 | 63786 | 52578 | 32397116 |
Metastasis | 20.08 | 12.73 | 30 | 63802 | 3627 | 32446067 |
Peritonitis | 20.05 | 12.73 | 92 | 63740 | 22238 | 32427456 |
Hepatectomy | 20.00 | 12.73 | 7 | 63825 | 70 | 32449624 |
Haemolytic anaemia | 19.98 | 12.73 | 56 | 63776 | 10628 | 32439066 |
Dysphonia | 19.91 | 12.73 | 87 | 63745 | 20597 | 32429097 |
Pulmonary artery thrombosis | 19.91 | 12.73 | 14 | 63818 | 684 | 32449010 |
Eyelash changes | 19.80 | 12.73 | 5 | 63827 | 13 | 32449681 |
Hypersplenism | 19.76 | 12.73 | 11 | 63821 | 354 | 32449340 |
Organising pneumonia | 19.74 | 12.73 | 38 | 63794 | 5643 | 32444051 |
Bronchitis | 19.60 | 12.73 | 32 | 63800 | 41475 | 32408219 |
Road traffic accident | 19.53 | 12.73 | 5 | 63827 | 17376 | 32432318 |
Thrombotic thrombocytopenic purpura | 19.51 | 12.73 | 29 | 63803 | 3491 | 32446203 |
Flushing | 19.48 | 12.73 | 116 | 63716 | 31011 | 32418683 |
Rectal abscess | 19.37 | 12.73 | 16 | 63816 | 996 | 32448698 |
Sepsis | 19.15 | 12.73 | 427 | 63405 | 158407 | 32291287 |
Lung neoplasm malignant | 19.11 | 12.73 | 4 | 63828 | 15959 | 32433735 |
K-ras gene mutation | 19.03 | 12.73 | 5 | 63827 | 16 | 32449678 |
Acute motor-sensory axonal neuropathy | 18.97 | 12.73 | 8 | 63824 | 137 | 32449557 |
Dysaesthesia | 18.90 | 12.73 | 23 | 63809 | 2285 | 32447409 |
Bacterial colitis | 18.90 | 12.73 | 6 | 63826 | 43 | 32449651 |
ECG signs of myocardial ischaemia | 18.88 | 12.73 | 9 | 63823 | 208 | 32449486 |
Performance status decreased | 18.87 | 12.73 | 31 | 63801 | 4067 | 32445627 |
Diffuse alveolar damage | 18.80 | 12.73 | 22 | 63810 | 2097 | 32447597 |
Gastrointestinal inflammation | 18.76 | 12.73 | 27 | 63805 | 3157 | 32446537 |
Posterior reversible encephalopathy syndrome | 18.70 | 12.73 | 51 | 63781 | 9525 | 32440169 |
Chronic kidney disease | 18.70 | 12.73 | 31 | 63801 | 39944 | 32409750 |
Jaundice | 18.70 | 12.73 | 123 | 63709 | 34035 | 32415659 |
Hyperkalaemia | 18.68 | 12.73 | 72 | 63760 | 69678 | 32380016 |
Malignant ascites | 18.67 | 12.73 | 11 | 63821 | 395 | 32449299 |
Pneumonitis | 18.67 | 12.73 | 112 | 63720 | 30022 | 32419672 |
Hepatitis B surface antigen positive | 18.66 | 12.73 | 8 | 63824 | 143 | 32449551 |
Arthritis | 18.65 | 12.73 | 15 | 63817 | 26677 | 32423017 |
Tremor | 18.65 | 12.73 | 89 | 63743 | 81188 | 32368506 |
Intentional product use issue | 18.60 | 12.73 | 34 | 63798 | 42177 | 32407517 |
B-cell small lymphocytic lymphoma | 18.46 | 12.73 | 8 | 63824 | 147 | 32449547 |
Pseudocirrhosis | 18.37 | 12.73 | 5 | 63827 | 19 | 32449675 |
Visceral venous thrombosis | 18.17 | 12.73 | 5 | 63827 | 20 | 32449674 |
Oesophagobronchial fistula | 18.17 | 12.73 | 8 | 63824 | 153 | 32449541 |
Stoma site pain | 18.15 | 12.73 | 15 | 63817 | 934 | 32448760 |
Embolism | 18.14 | 12.73 | 43 | 63789 | 7371 | 32442323 |
Respiratory arrest | 18.10 | 12.73 | 18 | 63814 | 28890 | 32420804 |
Angioedema | 18.06 | 12.73 | 27 | 63805 | 36262 | 32413432 |
Allodynia | 18.06 | 12.73 | 13 | 63819 | 659 | 32449035 |
Gastric perforation | 17.88 | 12.73 | 22 | 63810 | 2211 | 32447483 |
Perforation bile duct | 17.80 | 12.73 | 6 | 63826 | 53 | 32449641 |
Renal disorder | 17.79 | 12.73 | 14 | 63818 | 25169 | 32424525 |
Emotional distress | 17.74 | 12.73 | 5 | 63827 | 16301 | 32433393 |
Liver function test abnormal | 17.69 | 12.73 | 22 | 63810 | 31925 | 32417769 |
Diabetes mellitus | 17.67 | 12.73 | 39 | 63793 | 45134 | 32404560 |
Duodenal perforation | 17.52 | 12.73 | 17 | 63815 | 1308 | 32448386 |
Soft tissue swelling | 17.47 | 12.73 | 10 | 63822 | 340 | 32449354 |
Immune thrombocytopenia | 17.35 | 12.73 | 46 | 63786 | 8451 | 32441243 |
Rectosigmoid cancer | 17.31 | 12.73 | 8 | 63824 | 172 | 32449522 |
Organic brain syndrome | 17.31 | 12.73 | 9 | 63823 | 252 | 32449442 |
Heart rate increased | 17.29 | 12.73 | 35 | 63797 | 41793 | 32407901 |
Toxoplasmosis | 17.26 | 12.73 | 17 | 63815 | 1332 | 32448362 |
Non-cirrhotic portal hypertension | 17.18 | 12.73 | 9 | 63823 | 256 | 32449438 |
Guillain-Barre syndrome | 17.08 | 12.73 | 35 | 63797 | 5439 | 32444255 |
Irritability | 17.04 | 12.73 | 14 | 63818 | 24640 | 32425054 |
Neutrophil count decreased | 17 | 12.73 | 154 | 63678 | 46985 | 32402709 |
Neurosarcoidosis | 16.98 | 12.73 | 8 | 63824 | 180 | 32449514 |
Perineal disorder | 16.97 | 12.73 | 6 | 63826 | 62 | 32449632 |
Catheter site extravasation | 16.92 | 12.73 | 7 | 63825 | 114 | 32449580 |
Hepatic pain | 16.88 | 12.73 | 17 | 63815 | 1368 | 32448326 |
Dyskinesia | 16.82 | 12.73 | 13 | 63819 | 23590 | 32426104 |
Gastrointestinal anastomotic leak | 16.80 | 12.73 | 10 | 63822 | 366 | 32449328 |
Electromyogram abnormal | 16.80 | 12.73 | 6 | 63826 | 64 | 32449630 |
Proctitis | 16.78 | 12.73 | 22 | 63810 | 2356 | 32447338 |
Stress cardiomyopathy | 16.62 | 12.73 | 19 | 63813 | 1767 | 32447927 |
Change of bowel habit | 16.58 | 12.73 | 15 | 63817 | 1056 | 32448638 |
Pelvic inflammatory disease | 16.56 | 12.73 | 4 | 63828 | 8 | 32449686 |
Intrahepatic portal hepatic venous fistula | 16.56 | 12.73 | 4 | 63828 | 8 | 32449686 |
Laryngospasm | 16.52 | 12.73 | 17 | 63815 | 1404 | 32448290 |
Streptococcal bacteraemia | 16.50 | 12.73 | 19 | 63813 | 1781 | 32447913 |
Drug hypersensitivity | 16.47 | 12.73 | 81 | 63751 | 73319 | 32376375 |
Respiratory depression | 16.47 | 12.73 | 3 | 63829 | 13208 | 32436486 |
Intestinal strangulation | 16.37 | 12.73 | 5 | 63827 | 31 | 32449663 |
Nasopharyngitis | 16.35 | 12.73 | 67 | 63765 | 63720 | 32385974 |
Retroperitoneal abscess | 16.32 | 12.73 | 8 | 63824 | 197 | 32449497 |
Metastases to pelvis | 16.27 | 12.73 | 9 | 63823 | 286 | 32449408 |
Vocal cord paralysis | 16.14 | 12.73 | 14 | 63818 | 932 | 32448762 |
Radiation interaction | 16.10 | 12.73 | 5 | 63827 | 33 | 32449661 |
Renal impairment | 16.09 | 12.73 | 110 | 63722 | 91862 | 32357832 |
Haematoma | 16.07 | 12.73 | 16 | 63816 | 25668 | 32424026 |
Tumour fistulisation | 15.95 | 12.73 | 4 | 63828 | 10 | 32449684 |
Off label use | 15.87 | 12.73 | 744 | 63088 | 305576 | 32144118 |
Septic shock | 15.86 | 12.73 | 206 | 63626 | 68783 | 32380911 |
Product quality issue | 15.86 | 12.73 | 9 | 63823 | 19224 | 32430470 |
Brief psychotic disorder with marked stressors | 15.78 | 12.73 | 8 | 63824 | 212 | 32449482 |
Neck pain | 15.68 | 12.73 | 13 | 63819 | 22774 | 32426920 |
Astringent therapy | 15.68 | 12.73 | 4 | 63828 | 11 | 32449683 |
Candida infection | 15.66 | 12.73 | 70 | 63762 | 16733 | 32432961 |
Colorectal cancer recurrent | 15.61 | 12.73 | 5 | 63827 | 37 | 32449657 |
Paraneoplastic syndrome | 15.60 | 12.73 | 11 | 63821 | 540 | 32449154 |
Odynophagia | 15.50 | 12.73 | 32 | 63800 | 4999 | 32444695 |
Balance disorder | 15.48 | 12.73 | 34 | 63798 | 39425 | 32410269 |
Heart rate decreased | 15.42 | 12.73 | 16 | 63816 | 25184 | 32424510 |
Temperature difference of extremities | 15.42 | 12.73 | 4 | 63828 | 12 | 32449682 |
Abscess | 15.39 | 12.73 | 51 | 63781 | 10599 | 32439095 |
Lip swelling | 15.39 | 12.73 | 4 | 63828 | 13761 | 32435933 |
Acinetobacter sepsis | 15.38 | 12.73 | 5 | 63827 | 39 | 32449655 |
Bladder hypertrophy | 15.33 | 12.73 | 11 | 63821 | 555 | 32449139 |
Periportal sinus dilatation | 15.16 | 12.73 | 5 | 63827 | 41 | 32449653 |
Xerosis | 15.14 | 12.73 | 11 | 63821 | 566 | 32449128 |
Neutropenic sepsis | 15.07 | 12.73 | 57 | 63775 | 12642 | 32437052 |
Injection site erythema | 15.05 | 12.73 | 5 | 63827 | 14663 | 32435031 |
Retinitis viral | 15.01 | 12.73 | 6 | 63826 | 89 | 32449605 |
Pelvic venous thrombosis | 15.00 | 12.73 | 11 | 63821 | 574 | 32449120 |
Portal shunt | 14.95 | 12.73 | 5 | 63827 | 43 | 32449651 |
Swelling | 14.94 | 12.73 | 33 | 63799 | 38189 | 32411505 |
Hypoacusis | 14.92 | 12.73 | 6 | 63826 | 15635 | 32434059 |
Pneumonia aspiration | 14.92 | 12.73 | 37 | 63795 | 41119 | 32408575 |
Limbic encephalitis | 14.89 | 12.73 | 9 | 63823 | 339 | 32449355 |
Accidental overdose | 14.63 | 12.73 | 10 | 63822 | 19329 | 32430365 |
Seizure | 14.54 | 12.73 | 132 | 63700 | 103722 | 32345972 |
Paraesthesia mucosal | 14.53 | 12.73 | 4 | 63828 | 16 | 32449678 |
Peritoneal adhesions | 14.43 | 12.73 | 6 | 63826 | 99 | 32449595 |
Urticaria | 14.43 | 12.73 | 64 | 63768 | 59550 | 32390144 |
Cerebral haemorrhage | 14.42 | 12.73 | 29 | 63803 | 34718 | 32414976 |
Palmar erythema | 14.36 | 12.73 | 8 | 63824 | 258 | 32449436 |
Gait inability | 14.34 | 12.73 | 11 | 63821 | 20036 | 32429658 |
Rectal cancer recurrent | 14.34 | 12.73 | 4 | 63828 | 17 | 32449677 |
Extrapyramidal disorder | 14.20 | 12.73 | 3 | 63829 | 11892 | 32437802 |
Blood pressure decreased | 14.15 | 12.73 | 52 | 63780 | 51028 | 32398666 |
Dyspnoea | 14.03 | 12.73 | 575 | 63257 | 361470 | 32088224 |
Prostate cancer | 14.02 | 12.73 | 20 | 63812 | 27386 | 32422308 |
Cardiac arrest | 13.99 | 12.73 | 122 | 63710 | 96654 | 32353040 |
Full blood count decreased | 13.97 | 12.73 | 8 | 63824 | 17002 | 32432692 |
Hepatic cancer recurrent | 13.97 | 12.73 | 9 | 63823 | 380 | 32449314 |
Gout | 13.75 | 12.73 | 10 | 63822 | 18718 | 32430976 |
Faeces discoloured | 13.72 | 12.73 | 6 | 63826 | 14871 | 32434823 |
Gastrointestinal haemorrhage | 13.71 | 12.73 | 107 | 63725 | 86775 | 32362919 |
Dry skin | 13.70 | 12.73 | 90 | 63742 | 24888 | 32424806 |
Urinary tract obstruction | 13.70 | 12.73 | 25 | 63807 | 3566 | 32446128 |
Psychotic disorder | 13.66 | 12.73 | 15 | 63817 | 23005 | 32426689 |
VIth nerve disorder | 13.65 | 12.73 | 4 | 63828 | 21 | 32449673 |
Injection site reaction | 13.64 | 12.73 | 3 | 63829 | 11566 | 32438128 |
Anorectal infection | 13.56 | 12.73 | 7 | 63825 | 193 | 32449501 |
Pulmonary oedema | 13.55 | 12.73 | 46 | 63786 | 46221 | 32403473 |
Onychoclasis | 13.48 | 12.73 | 17 | 63815 | 1751 | 32447943 |
Tracheal inflammation | 13.47 | 12.73 | 5 | 63827 | 60 | 32449634 |
Herpes zoster | 13.42 | 12.73 | 27 | 63805 | 32314 | 32417380 |
Malaise | 13.41 | 12.73 | 256 | 63576 | 176882 | 32272812 |
Prostatic calcification | 13.38 | 12.73 | 6 | 63826 | 120 | 32449574 |
Aphthous ulcer | 13.35 | 12.73 | 28 | 63804 | 4423 | 32445271 |
Peritoneal disorder | 13.24 | 12.73 | 9 | 63823 | 416 | 32449278 |
Blood glucose decreased | 13.22 | 12.73 | 5 | 63827 | 13529 | 32436165 |
Visual impairment | 13.18 | 12.73 | 28 | 63804 | 32860 | 32416834 |
Tumour perforation | 13.15 | 12.73 | 8 | 63824 | 305 | 32449389 |
Hepatitis B DNA increased | 13.10 | 12.73 | 10 | 63822 | 555 | 32449139 |
Ocular toxicity | 13.08 | 12.73 | 7 | 63825 | 208 | 32449486 |
Crystal nephropathy | 13.07 | 12.73 | 9 | 63823 | 425 | 32449269 |
Klebsiella infection | 13.07 | 12.73 | 40 | 63792 | 7972 | 32441722 |
Pleural fistula | 13.07 | 12.73 | 4 | 63828 | 25 | 32449669 |
Iatrogenic infection | 13.04 | 12.73 | 5 | 63827 | 66 | 32449628 |
Bacteriuria | 13.01 | 12.73 | 8 | 63824 | 311 | 32449383 |
Laboratory test abnormal | 13.00 | 12.73 | 11 | 63821 | 19076 | 32430618 |
Nephrolithiasis | 12.99 | 12.73 | 21 | 63811 | 27333 | 32422361 |
Metastatic neoplasm | 12.99 | 12.73 | 22 | 63810 | 2959 | 32446735 |
Demyelinating polyneuropathy | 12.91 | 12.73 | 14 | 63818 | 1228 | 32448466 |
Erectile dysfunction | 12.83 | 12.73 | 12 | 63820 | 19827 | 32429867 |
Blood lactic acid increased | 12.82 | 12.73 | 34 | 63798 | 6247 | 32443447 |
Gastrooesophageal reflux disease | 12.77 | 12.73 | 31 | 63801 | 34707 | 32414987 |
Source | Code | Description |
---|---|---|
ATC | V03AF03 | VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Detoxifying agents for antineoplastic treatment |
ATC | V03AF06 | VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Detoxifying agents for antineoplastic treatment |
FDA CS | M0008658 | Folic Acid |
MeSH PA | D000931 | Antidotes |
MeSH PA | D018977 | Micronutrients |
MeSH PA | D020011 | Protective Agents |
MeSH PA | D014803 | Vitamin B Complex |
MeSH PA | D014815 | Vitamins |
CHEBI has role | CHEBI:75771 | Mus musculus metabolite |
CHEBI has role | CHEBI:76971 | E.coli metabolites |
FDA EPC | N0000178369 | Folate Analog |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Megaloblastic anemia | indication | 53165003 | DOID:13382 |
Folic acid deficiency | indication | 190633005 | |
Bone Marrow Suppression due to Folic Acid Antagonism | indication | ||
Methotrexate Toxicity | indication | ||
Trimethoprim Toxicity | indication | ||
Trimetrexate Toxicity | indication | ||
Sulfadiazine Toxicity | indication | ||
Pyrimethamine Toxicity | indication | ||
Adjunct to Fluorouracil Treatment of Colorectal Cancer | indication | ||
Pernicious anemia | contraindication | 84027009 | DOID:13381 |
Cobalamin deficiency | contraindication | 190634004 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.61 | acidic |
pKa2 | 5.29 | acidic |
pKa3 | 10.26 | acidic |
pKa4 | 12.96 | acidic |
pKa5 | 4.59 | Basic |
pKa6 | 2.23 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Thymidylate synthase | Enzyme | Ki | 4.07 | WOMBAT-PK | |||||
Dihydrofolate reductase | Enzyme | Ki | 5.63 | CHEMBL |
ID | Source |
---|---|
4019798 | VUID |
N0000147887 | NUI |
D01211 | KEGG_DRUG |
1492-18-8 | SECONDARY_CAS_RN |
4018768 | VANDF |
4019798 | VANDF |
4031236 | VANDF |
C0023413 | UMLSCUI |
CHEBI:15640 | CHEBI |
CHEMBL1679 | ChEMBL_ID |
CHEMBL3707260 | ChEMBL_ID |
CHEMBL1232801 | ChEMBL_ID |
CHEMBL1201138 | ChEMBL_ID |
D002955 | MESH_DESCRIPTOR_UI |
DB00650 | DRUGBANK_ID |
4816 | IUPHAR_LIGAND_ID |
690 | INN_ID |
Q573I9DVLP | UNII |
135403648 | PUBCHEM_CID |
225852 | RXNORM |
1728 | MMSL |
39896 | MMSL |
4964 | MMSL |
51342 | MMSL |
d00275 | MMSL |
001050 | NDDF |
001051 | NDDF |
009520 | NDDF |
126223008 | SNOMEDCT_US |
1528001 | SNOMEDCT_US |
396065004 | SNOMEDCT_US |
768550004 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-4496 | TABLET | 5 mg | ORAL | ANDA | 15 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-4497 | TABLET | 10 mg | ORAL | ANDA | 15 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-4498 | TABLET | 15 mg | ORAL | ANDA | 15 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-4499 | TABLET | 25 mg | ORAL | ANDA | 15 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-8496 | TABLET | 5 mg | ORAL | ANDA | 15 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9368 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 200 mg | INTRAMUSCULAR | ANDA | 19 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9552 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 350 mg | INTRAMUSCULAR | ANDA | 19 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9553 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 200 mg | INTRAMUSCULAR | ANDA | 19 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9554 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 100 mg | INTRAMUSCULAR | ANDA | 19 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9555 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 50 mg | INTRAMUSCULAR | ANDA | 19 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0484 | TABLET | 5 mg | ORAL | ANDA | 17 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0485 | TABLET | 25 mg | ORAL | ANDA | 17 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-5140 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 100 mg | INTRAMUSCULAR | ANDA | 18 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-5145 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 350 mg | INTRAMUSCULAR | ANDA | 18 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-5145 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 350 mg | INTRAMUSCULAR | ANDA | 18 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6703 | TABLET | 25 mg | ORAL | ANDA | 15 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-813 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 50 mg | INTRAVENOUS | ANDA | 21 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-814 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 100 mg | INTRAVENOUS | ANDA | 21 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-815 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 200 mg | INTRAVENOUS | ANDA | 21 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-816 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 350 mg | INTRAVENOUS | ANDA | 21 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-828 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 21 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42806-133 | TABLET | 10 mg | ORAL | ANDA | 16 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42806-134 | TABLET | 15 mg | ORAL | ANDA | 16 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42806-358 | TABLET | 5 mg | ORAL | ANDA | 16 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42806-359 | TABLET | 25 mg | ORAL | ANDA | 16 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50742-181 | TABLET | 5 mg | ORAL | ANDA | 17 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50742-182 | TABLET | 10 mg | ORAL | ANDA | 17 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50742-183 | TABLET | 15 mg | ORAL | ANDA | 17 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50742-184 | TABLET | 25 mg | ORAL | ANDA | 17 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51079-581 | TABLET | 5 mg | ORAL | ANDA | 17 sections |