Stem definition | Drug id | CAS RN |
---|---|---|
1232 | 58-05-9 |
Dose | Unit | Route |
---|---|---|
60 | mg | O |
60 | mg | P |
60 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 500 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 10 % | Benet LZ, Broccatelli F, Oprea TI |
BA (Bioavailability) | 4 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.25 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 5.80 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.09 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.30 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
June 20, 1952 | FDA | ||
Nov. 25, 2021 | PMDA | PFIZER JAPAN INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neutropenia | 1043.77 | 12.04 | 993 | 52193 | 157174 | 56081707 |
Neuropathy peripheral | 549.98 | 12.04 | 577 | 52609 | 102316 | 56136565 |
Neurotoxicity | 475.73 | 12.04 | 252 | 52934 | 15543 | 56223338 |
Mucosal inflammation | 427.27 | 12.04 | 341 | 52845 | 42469 | 56196412 |
Thrombocytopenia | 414.76 | 12.04 | 574 | 52612 | 135650 | 56103231 |
Diarrhoea | 320.17 | 12.04 | 1318 | 51868 | 637189 | 55601692 |
Disease progression | 301.80 | 12.04 | 431 | 52755 | 104742 | 56134139 |
Skin toxicity | 280.88 | 12.04 | 116 | 53070 | 4037 | 56234844 |
Febrile neutropenia | 273.12 | 12.04 | 412 | 52774 | 105133 | 56133748 |
Haematotoxicity | 219.66 | 12.04 | 122 | 53064 | 8261 | 56230620 |
Leukopenia | 206.71 | 12.04 | 293 | 52893 | 70647 | 56168234 |
Polyneuropathy | 200.56 | 12.04 | 135 | 53051 | 12915 | 56225966 |
Colorectal cancer metastatic | 200.28 | 12.04 | 60 | 53126 | 781 | 56238100 |
Dermatitis acneiform | 179.81 | 12.04 | 86 | 53100 | 4258 | 56234623 |
Vomiting | 162.39 | 12.04 | 910 | 52276 | 497318 | 55741563 |
Systemic lupus erythematosus | 144.33 | 12.04 | 6 | 53180 | 180072 | 56058809 |
Stomatitis | 130.68 | 12.04 | 326 | 52860 | 120484 | 56118397 |
Pancytopenia | 128.81 | 12.04 | 269 | 52917 | 88446 | 56150435 |
Palmar-plantar erythrodysaesthesia syndrome | 128.38 | 12.04 | 127 | 53059 | 20938 | 56217943 |
Posterior reversible encephalopathy syndrome | 127.75 | 12.04 | 112 | 53074 | 15848 | 56223033 |
Nausea | 127.19 | 12.04 | 1187 | 51999 | 762991 | 55475890 |
Arteriospasm coronary | 126.47 | 12.04 | 64 | 53122 | 3583 | 56235298 |
Anaemia | 123.48 | 12.04 | 540 | 52646 | 266971 | 55971910 |
Glossodynia | 122.42 | 12.04 | 5 | 53181 | 152453 | 56086428 |
Metastases to liver | 120.32 | 12.04 | 124 | 53062 | 21462 | 56217419 |
Pulmonary embolism | 120.00 | 12.04 | 293 | 52893 | 106831 | 56132050 |
Myelosuppression | 111.53 | 12.04 | 108 | 53078 | 17347 | 56221534 |
Malignant neoplasm progression | 108.99 | 12.04 | 225 | 52961 | 73362 | 56165519 |
Bone marrow failure | 107.26 | 12.04 | 133 | 53053 | 28153 | 56210728 |
Abdominal pain | 106.41 | 12.04 | 505 | 52681 | 258300 | 55980581 |
Non-cirrhotic portal hypertension | 104.95 | 12.04 | 26 | 53160 | 154 | 56238727 |
Enteritis | 104.89 | 12.04 | 73 | 53113 | 7370 | 56231511 |
Arthropathy | 104.21 | 12.04 | 30 | 53156 | 200245 | 56038636 |
Swelling | 96.84 | 12.04 | 53 | 53133 | 239718 | 55999163 |
Gastrointestinal toxicity | 95.33 | 12.04 | 64 | 53122 | 6092 | 56232789 |
Drug clearance decreased | 95.29 | 12.04 | 39 | 53147 | 1325 | 56237556 |
Focal nodular hyperplasia | 89.71 | 12.04 | 29 | 53157 | 492 | 56238389 |
Portal hypertension | 88.59 | 12.04 | 50 | 53136 | 3491 | 56235390 |
Therapy partial responder | 86.21 | 12.04 | 66 | 53120 | 7719 | 56231162 |
Product dose omission issue | 86.00 | 12.04 | 43 | 53143 | 204710 | 56034171 |
Peripheral swelling | 82.28 | 12.04 | 61 | 53125 | 234665 | 56004216 |
Peripheral sensory neuropathy | 79.29 | 12.04 | 60 | 53126 | 6896 | 56231985 |
Loss of employment | 79.10 | 12.04 | 38 | 53148 | 1899 | 56236982 |
Proteinuria | 77.10 | 12.04 | 89 | 53097 | 17481 | 56221400 |
Synovitis | 75.43 | 12.04 | 29 | 53157 | 161276 | 56077605 |
Hand deformity | 72.08 | 12.04 | 19 | 53167 | 134473 | 56104408 |
Gastrointestinal perforation | 71.56 | 12.04 | 42 | 53144 | 3157 | 56235724 |
Adenocarcinoma of colon | 70.08 | 12.04 | 38 | 53148 | 2452 | 56236429 |
Hypomagnesaemia | 69.38 | 12.04 | 101 | 53085 | 24914 | 56213967 |
Paronychia | 68.75 | 12.04 | 48 | 53138 | 4870 | 56234011 |
Pericarditis | 67.40 | 12.04 | 11 | 53175 | 108912 | 56129969 |
Wound | 66.50 | 12.04 | 24 | 53162 | 138780 | 56100101 |
Discomfort | 65.43 | 12.04 | 26 | 53160 | 141735 | 56097146 |
Human bocavirus infection | 64.97 | 12.04 | 21 | 53165 | 356 | 56238525 |
Dysarthria | 64.59 | 12.04 | 126 | 53060 | 39424 | 56199457 |
Leukoencephalopathy | 64.56 | 12.04 | 43 | 53143 | 4039 | 56234842 |
Dehydration | 63.77 | 12.04 | 308 | 52878 | 158517 | 56080364 |
Neoplasm progression | 63.62 | 12.04 | 111 | 53075 | 31905 | 56206976 |
Secondary immunodeficiency | 62.05 | 12.04 | 28 | 53158 | 1212 | 56237669 |
Fall | 57.78 | 12.04 | 161 | 53025 | 357349 | 55881532 |
Abdominal discomfort | 55.87 | 12.04 | 111 | 53075 | 277163 | 55961718 |
Insomnia | 55.07 | 12.04 | 60 | 53126 | 191800 | 56047081 |
Lower respiratory tract infection | 54.72 | 12.04 | 20 | 53166 | 114774 | 56124107 |
Pneumatosis intestinalis | 54.43 | 12.04 | 31 | 53155 | 2202 | 56236679 |
Hypertension | 54.40 | 12.04 | 406 | 52780 | 243872 | 55995009 |
Metastases to lung | 54.19 | 12.04 | 61 | 53125 | 11657 | 56227224 |
General physical health deterioration | 54.00 | 12.04 | 309 | 52877 | 169701 | 56069180 |
Pain | 53.65 | 12.04 | 387 | 52799 | 662797 | 55576084 |
Hepatic enzyme increased | 53.29 | 12.04 | 50 | 53136 | 171334 | 56067547 |
Helicobacter infection | 51.12 | 12.04 | 5 | 53181 | 73263 | 56165618 |
Pyrexia | 51.04 | 12.04 | 612 | 52574 | 418161 | 55820720 |
Hyperammonaemia | 50.61 | 12.04 | 40 | 53146 | 4900 | 56233981 |
Intestinal perforation | 50.60 | 12.04 | 57 | 53129 | 10902 | 56227979 |
Splenomegaly | 50.59 | 12.04 | 55 | 53131 | 10113 | 56228768 |
Duodenal ulcer perforation | 49.48 | 12.04 | 4 | 53182 | 68338 | 56170543 |
Hyperammonaemic encephalopathy | 47.08 | 12.04 | 28 | 53158 | 2157 | 56236724 |
Off label use | 46.82 | 12.04 | 761 | 52425 | 555419 | 55683462 |
Drug abuse | 46.17 | 12.04 | 5 | 53181 | 67605 | 56171276 |
Gene mutation | 46.11 | 12.04 | 24 | 53162 | 1425 | 56237456 |
Ileus | 45.90 | 12.04 | 61 | 53125 | 13821 | 56225060 |
Joint swelling | 45.69 | 12.04 | 132 | 53054 | 289668 | 55949213 |
Contraindicated product administered | 45.38 | 12.04 | 66 | 53120 | 186220 | 56052661 |
Thrombocytopenic purpura | 45.19 | 12.04 | 23 | 53163 | 1303 | 56237578 |
Cholangitis | 44.22 | 12.04 | 37 | 53149 | 4912 | 56233969 |
Hepatocellular injury | 43.93 | 12.04 | 85 | 53101 | 26429 | 56212452 |
Metastases to meninges | 43.54 | 12.04 | 27 | 53159 | 2243 | 56236638 |
Enterobacter infection | 43.44 | 12.04 | 26 | 53160 | 2026 | 56236855 |
Blood cholesterol increased | 43.42 | 12.04 | 8 | 53178 | 72571 | 56166310 |
Hospitalisation | 43.33 | 12.04 | 9 | 53177 | 74991 | 56163890 |
Neutrophil count decreased | 42.27 | 12.04 | 123 | 53063 | 49699 | 56189182 |
Crystal nephropathy | 42.00 | 12.04 | 19 | 53167 | 827 | 56238054 |
Injury | 41.98 | 12.04 | 4 | 53182 | 59847 | 56179034 |
Hypersensitivity vasculitis | 41.95 | 12.04 | 33 | 53153 | 4015 | 56234866 |
Steatohepatitis | 41.18 | 12.04 | 16 | 53170 | 473 | 56238408 |
Cystitis radiation | 39.97 | 12.04 | 10 | 53176 | 62 | 56238819 |
Herpes simplex | 39.75 | 12.04 | 42 | 53144 | 7476 | 56231405 |
Pharyngeal dyskinesia | 39.24 | 12.04 | 9 | 53177 | 36 | 56238845 |
Colon cancer metastatic | 38.84 | 12.04 | 20 | 53166 | 1161 | 56237720 |
Bladder tamponade | 38.80 | 12.04 | 10 | 53176 | 71 | 56238810 |
Drug hypersensitivity | 38.68 | 12.04 | 132 | 53054 | 275073 | 55963808 |
Epistaxis | 38.51 | 12.04 | 145 | 53041 | 66878 | 56172003 |
Hypokalaemia | 38.48 | 12.04 | 184 | 53002 | 94253 | 56144628 |
Rash pustular | 38.43 | 12.04 | 39 | 53147 | 6624 | 56232257 |
Venous thrombosis | 38.38 | 12.04 | 33 | 53153 | 4547 | 56234334 |
Gastroenteritis norovirus | 38.18 | 12.04 | 23 | 53163 | 1814 | 56237067 |
Septic shock | 37.81 | 12.04 | 135 | 53051 | 60700 | 56178181 |
Cardiotoxicity | 37.40 | 12.04 | 41 | 53145 | 7609 | 56231272 |
Blister | 37.21 | 12.04 | 29 | 53157 | 108858 | 56130023 |
Atypical haemolytic uraemic syndrome | 37.16 | 12.04 | 16 | 53170 | 618 | 56238263 |
Embolism | 36.93 | 12.04 | 40 | 53146 | 7324 | 56231557 |
Depression | 36.34 | 12.04 | 72 | 53114 | 180045 | 56058836 |
Factor VII deficiency | 36.17 | 12.04 | 8 | 53178 | 26 | 56238855 |
Neuromyotonia | 36.09 | 12.04 | 9 | 53177 | 55 | 56238826 |
Leukoerythroblastosis | 35.90 | 12.04 | 12 | 53174 | 227 | 56238654 |
T-cell lymphoma refractory | 35.81 | 12.04 | 9 | 53177 | 57 | 56238824 |
Sepsis | 35.49 | 12.04 | 240 | 52946 | 139600 | 56099281 |
Asthma | 34.92 | 12.04 | 33 | 53153 | 112737 | 56126144 |
Gastric varices haemorrhage | 34.59 | 12.04 | 10 | 53176 | 114 | 56238767 |
Mucosal toxicity | 34.53 | 12.04 | 13 | 53173 | 352 | 56238529 |
Neoplasm recurrence | 34.33 | 12.04 | 24 | 53162 | 2440 | 56236441 |
Venous pressure jugular decreased | 34.12 | 12.04 | 8 | 53178 | 36 | 56238845 |
Ascites | 34.09 | 12.04 | 95 | 53091 | 37449 | 56201432 |
Interstitial lung disease | 34.08 | 12.04 | 125 | 53061 | 56938 | 56181943 |
Trichomegaly | 33.77 | 12.04 | 8 | 53178 | 38 | 56238843 |
Second primary malignancy | 33.32 | 12.04 | 38 | 53148 | 7364 | 56231517 |
Laryngospasm | 33.14 | 12.04 | 25 | 53161 | 2859 | 56236022 |
Folliculitis | 33.02 | 12.04 | 6 | 53180 | 54973 | 56183908 |
Immune thrombocytopenia | 32.91 | 12.04 | 43 | 53143 | 9582 | 56229299 |
Chills | 32.88 | 12.04 | 187 | 52999 | 102417 | 56136464 |
Cholestasis | 32.66 | 12.04 | 76 | 53110 | 26837 | 56212044 |
Device related infection | 32.48 | 12.04 | 67 | 53119 | 21813 | 56217068 |
Short-bowel syndrome | 31.70 | 12.04 | 13 | 53173 | 444 | 56238437 |
Stress cardiomyopathy | 31.28 | 12.04 | 39 | 53147 | 8297 | 56230584 |
Nicotinic acid deficiency | 31.27 | 12.04 | 8 | 53178 | 55 | 56238826 |
Contusion | 30.78 | 12.04 | 46 | 53140 | 128384 | 56110497 |
Mobility decreased | 30.61 | 12.04 | 29 | 53157 | 98962 | 56139919 |
Sleep disorder | 30.25 | 12.04 | 13 | 53173 | 67650 | 56171231 |
Myelodysplastic syndrome | 30.17 | 12.04 | 55 | 53131 | 16351 | 56222530 |
Dizziness | 30.05 | 12.04 | 220 | 52966 | 375920 | 55862961 |
Rheumatoid arthritis | 29.99 | 12.04 | 225 | 52961 | 382379 | 55856502 |
Aortic thrombosis | 29.96 | 12.04 | 16 | 53170 | 1001 | 56237880 |
Nasal septum perforation | 29.13 | 12.04 | 14 | 53172 | 700 | 56238181 |
Large intestinal obstruction | 29.05 | 12.04 | 20 | 53166 | 1983 | 56236898 |
Injection site pain | 28.99 | 12.04 | 41 | 53145 | 117077 | 56121804 |
Intestinal obstruction | 28.64 | 12.04 | 74 | 53112 | 27897 | 56210984 |
Vena cava thrombosis | 28.47 | 12.04 | 20 | 53166 | 2049 | 56236832 |
Anastomotic leak | 28.43 | 12.04 | 12 | 53174 | 441 | 56238440 |
Sinusitis | 28.27 | 12.04 | 94 | 53092 | 197487 | 56041394 |
Encapsulating peritoneal sclerosis | 28.07 | 12.04 | 11 | 53175 | 333 | 56238548 |
Neutropenic colitis | 27.65 | 12.04 | 22 | 53164 | 2721 | 56236160 |
Drug ineffective | 27.40 | 12.04 | 661 | 52525 | 918328 | 55320553 |
Haemolytic anaemia | 26.70 | 12.04 | 39 | 53147 | 9646 | 56229235 |
Rhinovirus infection | 26.44 | 12.04 | 25 | 53161 | 3897 | 56234984 |
Catabolic state | 26.32 | 12.04 | 7 | 53179 | 57 | 56238824 |
Wrong technique in product usage process | 26.28 | 12.04 | 11 | 53175 | 58157 | 56180724 |
Memory impairment | 26.02 | 12.04 | 26 | 53160 | 86531 | 56152350 |
Weight increased | 26.01 | 12.04 | 120 | 53066 | 229583 | 56009298 |
Hip arthroplasty | 26.01 | 12.04 | 3 | 53183 | 38620 | 56200261 |
Aortic intramural haematoma | 25.90 | 12.04 | 7 | 53179 | 61 | 56238820 |
Chronic obstructive pulmonary disease | 25.71 | 12.04 | 11 | 53175 | 57404 | 56181477 |
Portal vein thrombosis | 25.64 | 12.04 | 20 | 53166 | 2403 | 56236478 |
Carcinoembryonic antigen increased | 25.54 | 12.04 | 17 | 53169 | 1595 | 56237286 |
Blood pressure fluctuation | 25.44 | 12.04 | 90 | 53096 | 40270 | 56198611 |
ECG signs of myocardial ischaemia | 25.32 | 12.04 | 7 | 53179 | 67 | 56238814 |
Maternal exposure during pregnancy | 25.22 | 12.04 | 93 | 53093 | 189460 | 56049421 |
Pain in extremity | 25.19 | 12.04 | 171 | 53015 | 297260 | 55941621 |
Treatment failure | 25.11 | 12.04 | 80 | 53106 | 170312 | 56068569 |
Clostridium difficile colitis | 25.06 | 12.04 | 55 | 53131 | 18683 | 56220198 |
Myeloid leukaemia | 24.96 | 12.04 | 10 | 53176 | 321 | 56238560 |
Tumour lysis syndrome | 24.95 | 12.04 | 34 | 53152 | 7889 | 56230992 |
Fluid retention | 24.80 | 12.04 | 10 | 53176 | 54068 | 56184813 |
Arthralgia | 24.70 | 12.04 | 330 | 52856 | 501339 | 55737542 |
Suicidal ideation | 24.40 | 12.04 | 12 | 53174 | 57730 | 56181151 |
Type II hypersensitivity | 24.34 | 12.04 | 5 | 53181 | 10 | 56238871 |
Meningitis streptococcal | 24.20 | 12.04 | 8 | 53178 | 146 | 56238735 |
Impaired healing | 23.97 | 12.04 | 28 | 53158 | 86813 | 56152068 |
Human herpesvirus 6 infection | 23.86 | 12.04 | 20 | 53166 | 2662 | 56236219 |
Haemolytic uraemic syndrome | 23.60 | 12.04 | 19 | 53167 | 2389 | 56236492 |
Electrocardiogram QT prolonged | 23.60 | 12.04 | 11 | 53175 | 54577 | 56184304 |
Depilation | 23.44 | 12.04 | 5 | 53181 | 13 | 56238868 |
Metastases to ovary | 23.35 | 12.04 | 10 | 53176 | 381 | 56238500 |
Peritonitis | 23.33 | 12.04 | 49 | 53137 | 16153 | 56222728 |
Respiratory symptom | 23.17 | 12.04 | 20 | 53166 | 2770 | 56236111 |
Deep vein thrombosis | 23.16 | 12.04 | 138 | 53048 | 76839 | 56162042 |
Cholinergic syndrome | 22.71 | 12.04 | 10 | 53176 | 408 | 56238473 |
Adverse drug reaction | 22.69 | 12.04 | 17 | 53169 | 65115 | 56173766 |
K-ras gene mutation | 22.44 | 12.04 | 5 | 53181 | 17 | 56238864 |
Plasma cell myeloma | 22.43 | 12.04 | 8 | 53178 | 46638 | 56192243 |
Acute kidney injury | 22.26 | 12.04 | 335 | 52851 | 240428 | 55998453 |
Inferior vena cava stenosis | 22.21 | 12.04 | 5 | 53181 | 18 | 56238863 |
Venoocclusive liver disease | 22.14 | 12.04 | 24 | 53162 | 4397 | 56234484 |
Metastases to lymph nodes | 22.09 | 12.04 | 31 | 53155 | 7392 | 56231489 |
Gastrointestinal anastomotic leak | 21.89 | 12.04 | 8 | 53178 | 199 | 56238682 |
Petechiae | 21.84 | 12.04 | 42 | 53144 | 12997 | 56225884 |
Female genital tract fistula | 21.83 | 12.04 | 24 | 53162 | 4468 | 56234413 |
Hepatic steatosis | 21.54 | 12.04 | 64 | 53122 | 26150 | 56212731 |
Exposure during pregnancy | 21.52 | 12.04 | 62 | 53124 | 136280 | 56102601 |
Psoriasis | 21.44 | 12.04 | 34 | 53152 | 92658 | 56146223 |
Peripheral sensorimotor neuropathy | 21.15 | 12.04 | 14 | 53172 | 1301 | 56237580 |
Gastrointestinal stoma complication | 21.15 | 12.04 | 15 | 53171 | 1560 | 56237321 |
Superior vena cava syndrome | 21.10 | 12.04 | 11 | 53175 | 655 | 56238226 |
Ocular toxicity | 21.06 | 12.04 | 11 | 53175 | 658 | 56238223 |
Asthenia | 20.98 | 12.04 | 447 | 52739 | 342526 | 55896355 |
Portal vein dilatation | 20.73 | 12.04 | 5 | 53181 | 26 | 56238855 |
Multiple-drug resistance | 20.65 | 12.04 | 22 | 53164 | 3952 | 56234929 |
Knee arthroplasty | 20.60 | 12.04 | 8 | 53178 | 44251 | 56194630 |
Confusional state | 20.57 | 12.04 | 114 | 53072 | 208041 | 56030840 |
Subileus | 20.29 | 12.04 | 19 | 53167 | 2925 | 56235956 |
Oesophageal fistula | 20.22 | 12.04 | 7 | 53179 | 148 | 56238733 |
Abortion spontaneous | 20.21 | 12.04 | 8 | 53178 | 43745 | 56195136 |
Acute promyelocytic leukaemia | 20.20 | 12.04 | 12 | 53174 | 922 | 56237959 |
Cutaneous tuberculosis | 20.09 | 12.04 | 7 | 53179 | 151 | 56238730 |
Tumour necrosis | 19.97 | 12.04 | 11 | 53175 | 732 | 56238149 |
Pruritus | 19.95 | 12.04 | 197 | 52989 | 316426 | 55922455 |
Migraine | 19.92 | 12.04 | 32 | 53154 | 86765 | 56152116 |
Subacute cutaneous lupus erythematosus | 19.83 | 12.04 | 17 | 53169 | 2332 | 56236549 |
Administration site extravasation | 19.74 | 12.04 | 11 | 53175 | 749 | 56238132 |
Occult blood | 19.68 | 12.04 | 13 | 53173 | 1204 | 56237677 |
Cytopenia | 19.60 | 12.04 | 34 | 53152 | 9721 | 56229160 |
Vitiligo | 19.42 | 12.04 | 13 | 53173 | 1231 | 56237650 |
Large intestine perforation | 19.34 | 12.04 | 30 | 53156 | 7821 | 56231060 |
Red cell fragmentation syndrome | 19.34 | 12.04 | 5 | 53181 | 36 | 56238845 |
Paraesthesia | 19.13 | 12.04 | 198 | 52988 | 130316 | 56108565 |
Encephalopathy | 19.12 | 12.04 | 75 | 53111 | 35250 | 56203631 |
Venous thrombosis limb | 19.11 | 12.04 | 18 | 53168 | 2791 | 56236090 |
Overdose | 19.09 | 12.04 | 45 | 53141 | 105785 | 56133096 |
Soft tissue necrosis | 18.90 | 12.04 | 9 | 53177 | 441 | 56238440 |
Post procedural diarrhoea | 18.84 | 12.04 | 9 | 53177 | 444 | 56238437 |
Ovarian fibroma | 18.83 | 12.04 | 6 | 53180 | 97 | 56238784 |
Pelvic fluid collection | 18.70 | 12.04 | 11 | 53175 | 830 | 56238051 |
Drug resistance | 18.67 | 12.04 | 52 | 53134 | 20490 | 56218391 |
Mouth ulceration | 18.60 | 12.04 | 66 | 53120 | 29574 | 56209307 |
Varices oesophageal | 18.54 | 12.04 | 18 | 53168 | 2898 | 56235983 |
Hypertrichosis | 18.52 | 12.04 | 12 | 53174 | 1076 | 56237805 |
Intentional product misuse | 18.52 | 12.04 | 13 | 53173 | 51491 | 56187390 |
Haemoglobin increased | 18.36 | 12.04 | 19 | 53167 | 3301 | 56235580 |
Endometrial dysplasia | 18.33 | 12.04 | 4 | 53182 | 12 | 56238869 |
Hemiparesis | 18.17 | 12.04 | 53 | 53133 | 21437 | 56217444 |
Colitis | 18.14 | 12.04 | 83 | 53103 | 41728 | 56197153 |
Gait disturbance | 18.08 | 12.04 | 86 | 53100 | 163235 | 56075646 |
Joint noise | 17.93 | 12.04 | 20 | 53166 | 3784 | 56235097 |
Wheezing | 17.84 | 12.04 | 27 | 53159 | 74999 | 56163882 |
Portal shunt | 17.64 | 12.04 | 4 | 53182 | 15 | 56238866 |
Hypertransaminasaemia | 17.62 | 12.04 | 22 | 53164 | 4685 | 56234196 |
Hypocapnia | 17.52 | 12.04 | 8 | 53178 | 356 | 56238525 |
Feeling abnormal | 17.47 | 12.04 | 66 | 53120 | 133536 | 56105345 |
Jugular vein thrombosis | 17.26 | 12.04 | 17 | 53169 | 2786 | 56236095 |
Mixed adenoneuroendocrine carcinoma | 17.25 | 12.04 | 4 | 53182 | 17 | 56238864 |
Coronary artery disease | 17.17 | 12.04 | 4 | 53182 | 30792 | 56208089 |
Rash maculo-papular | 16.98 | 12.04 | 63 | 53123 | 28844 | 56210037 |
Reticulocytosis | 16.86 | 12.04 | 6 | 53180 | 138 | 56238743 |
Balance disorder | 16.82 | 12.04 | 29 | 53157 | 76491 | 56162390 |
Productive cough | 16.77 | 12.04 | 17 | 53169 | 56215 | 56182666 |
Sedation | 16.72 | 12.04 | 6 | 53180 | 34848 | 56204033 |
Small intestinal obstruction | 16.70 | 12.04 | 44 | 53142 | 16781 | 56222100 |
Cardiomyopathy | 16.63 | 12.04 | 43 | 53143 | 16215 | 56222666 |
C-reactive protein abnormal | 16.56 | 12.04 | 7 | 53179 | 36802 | 56202079 |
Autoimmune retinopathy | 16.55 | 12.04 | 4 | 53182 | 21 | 56238860 |
Proctalgia | 16.38 | 12.04 | 23 | 53163 | 5486 | 56233395 |
Adverse event | 16.22 | 12.04 | 17 | 53169 | 55359 | 56183522 |
Rectal cancer metastatic | 16.22 | 12.04 | 7 | 53179 | 272 | 56238609 |
Endothelial dysfunction | 16.17 | 12.04 | 6 | 53180 | 156 | 56238725 |
Enterocolitis | 15.93 | 12.04 | 26 | 53160 | 7078 | 56231803 |
Pneumothorax | 15.91 | 12.04 | 40 | 53146 | 14827 | 56224054 |
Dysphagia | 15.87 | 12.04 | 132 | 53054 | 81815 | 56157066 |
Anxiety | 15.87 | 12.04 | 112 | 53074 | 193060 | 56045821 |
Liver abscess | 15.80 | 12.04 | 16 | 53170 | 2710 | 56236171 |
Upper respiratory tract infection | 15.69 | 12.04 | 27 | 53159 | 71261 | 56167620 |
Hallucination | 15.66 | 12.04 | 14 | 53172 | 49135 | 56189746 |
Acquired gene mutation | 15.63 | 12.04 | 10 | 53176 | 877 | 56238004 |
Rotator cuff syndrome | 15.52 | 12.04 | 35 | 53151 | 12108 | 56226773 |
Thrombotic microangiopathy | 15.38 | 12.04 | 30 | 53156 | 9381 | 56229500 |
Product intolerance | 15.33 | 12.04 | 4 | 53182 | 30 | 56238851 |
Cardiac arrest | 15.33 | 12.04 | 37 | 53149 | 86277 | 56152604 |
Pelvic abscess | 15.25 | 12.04 | 12 | 53174 | 1460 | 56237421 |
Optic nerve disorder | 15.13 | 12.04 | 9 | 53177 | 693 | 56238188 |
Overgrowth fungal | 15.09 | 12.04 | 5 | 53181 | 92 | 56238789 |
Toxic encephalopathy | 15.06 | 12.04 | 23 | 53163 | 5915 | 56232966 |
Rectal cancer recurrent | 14.89 | 12.04 | 4 | 53182 | 34 | 56238847 |
Hepatic vein stenosis | 14.89 | 12.04 | 4 | 53182 | 34 | 56238847 |
Condition aggravated | 14.79 | 12.04 | 233 | 52953 | 344665 | 55894216 |
Hyperbilirubinaemia | 14.79 | 12.04 | 31 | 53155 | 10204 | 56228677 |
Hepatitis toxic | 14.74 | 12.04 | 16 | 53170 | 2936 | 56235945 |
Headache | 14.73 | 12.04 | 409 | 52777 | 558635 | 55680246 |
No adverse event | 14.71 | 12.04 | 8 | 53178 | 36366 | 56202515 |
Unevaluable event | 14.70 | 12.04 | 14 | 53172 | 47673 | 56191208 |
Depressed mood | 14.70 | 12.04 | 8 | 53178 | 36351 | 56202530 |
Periportal sinus dilatation | 14.61 | 12.04 | 3 | 53183 | 6 | 56238875 |
Accessory spleen | 14.61 | 12.04 | 3 | 53183 | 6 | 56238875 |
Optic disc hyperaemia | 14.61 | 12.04 | 3 | 53183 | 6 | 56238875 |
Metastases to peritoneum | 14.51 | 12.04 | 16 | 53170 | 2988 | 56235893 |
Pneumothorax spontaneous | 14.47 | 12.04 | 9 | 53177 | 751 | 56238130 |
Tumour perforation | 14.43 | 12.04 | 5 | 53181 | 106 | 56238775 |
Irritability | 14.35 | 12.04 | 5 | 53181 | 29583 | 56209298 |
Escherichia bacteraemia | 14.30 | 12.04 | 17 | 53169 | 3443 | 56235438 |
Pneumonia | 14.28 | 12.04 | 285 | 52901 | 406813 | 55832068 |
Multiple organ dysfunction syndrome | 14.24 | 12.04 | 92 | 53094 | 52678 | 56186203 |
Hepatic failure | 14.18 | 12.04 | 66 | 53120 | 33420 | 56205461 |
Throat tightness | 14.15 | 12.04 | 50 | 53136 | 22357 | 56216524 |
Tumour rupture | 14.13 | 12.04 | 5 | 53181 | 113 | 56238768 |
Vaginal infection | 14.12 | 12.04 | 24 | 53162 | 6753 | 56232128 |
Psychiatric decompensation | 14.06 | 12.04 | 11 | 53175 | 1327 | 56237554 |
Cardiomyopathy acute | 14.05 | 12.04 | 6 | 53180 | 227 | 56238654 |
Benign hydatidiform mole | 14.01 | 12.04 | 5 | 53181 | 116 | 56238765 |
Rectal perforation | 13.93 | 12.04 | 7 | 53179 | 386 | 56238495 |
Hypocalcaemia | 13.93 | 12.04 | 59 | 53127 | 28701 | 56210180 |
Hemianaesthesia | 13.91 | 12.04 | 7 | 53179 | 387 | 56238494 |
Amnesia | 13.82 | 12.04 | 14 | 53172 | 46308 | 56192573 |
Tubular breast carcinoma | 13.80 | 12.04 | 4 | 53182 | 46 | 56238835 |
Cachexia | 13.77 | 12.04 | 20 | 53166 | 4922 | 56233959 |
Myalgia | 13.76 | 12.04 | 71 | 53115 | 131954 | 56106927 |
Peripheral nerve injury | 13.65 | 12.04 | 7 | 53179 | 403 | 56238478 |
Bradycardia | 13.58 | 12.04 | 27 | 53159 | 67477 | 56171404 |
Loss of personal independence in daily activities | 13.58 | 12.04 | 36 | 53150 | 81333 | 56157548 |
Medication error | 13.56 | 12.04 | 12 | 53174 | 42323 | 56196558 |
Intracranial pressure increased | 13.55 | 12.04 | 19 | 53167 | 4526 | 56234355 |
Vaginal fistula | 13.54 | 12.04 | 7 | 53179 | 410 | 56238471 |
Agitation | 13.48 | 12.04 | 20 | 53166 | 56016 | 56182865 |
Muscle atrophy | 13.46 | 12.04 | 23 | 53163 | 6498 | 56232383 |
Cognitive disorder | 13.39 | 12.04 | 16 | 53170 | 49117 | 56189764 |
Chronic kidney disease | 13.38 | 12.04 | 12 | 53174 | 42044 | 56196837 |
Colon cancer recurrent | 13.36 | 12.04 | 4 | 53182 | 52 | 56238829 |
Ill-defined disorder | 13.30 | 12.04 | 28 | 53158 | 68515 | 56170366 |
Somnolence | 13.29 | 12.04 | 95 | 53091 | 163318 | 56075563 |
Gastroenteropancreatic neuroendocrine tumour disease | 13.22 | 12.04 | 4 | 53182 | 54 | 56238827 |
Disease recurrence | 13.19 | 12.04 | 51 | 53135 | 23809 | 56215072 |
Drug eruption | 13.12 | 12.04 | 4 | 53182 | 25759 | 56213122 |
Therapeutic product effect decreased | 13.07 | 12.04 | 100 | 53086 | 169352 | 56069529 |
Eczema asteatotic | 13.06 | 12.04 | 6 | 53180 | 271 | 56238610 |
Product use in unapproved indication | 13.02 | 12.04 | 196 | 52990 | 140626 | 56098255 |
Hepatic lesion | 13.01 | 12.04 | 18 | 53168 | 4237 | 56234644 |
Bone pain | 12.99 | 12.04 | 17 | 53169 | 50168 | 56188713 |
Visual acuity reduced transiently | 12.93 | 12.04 | 5 | 53181 | 146 | 56238735 |
Metastases to spleen | 12.89 | 12.04 | 5 | 53181 | 147 | 56238734 |
Anaemia of malignant disease | 12.88 | 12.04 | 7 | 53179 | 454 | 56238427 |
Nodular regenerative hyperplasia | 12.86 | 12.04 | 7 | 53179 | 455 | 56238426 |
Ovarian cystectomy | 12.83 | 12.04 | 5 | 53181 | 149 | 56238732 |
Metastasis | 12.80 | 12.04 | 19 | 53167 | 4765 | 56234116 |
Colorectal cancer | 12.80 | 12.04 | 16 | 53170 | 3413 | 56235468 |
Granulomatous lymphadenitis | 12.77 | 12.04 | 5 | 53181 | 151 | 56238730 |
Blood glucose increased | 12.73 | 12.04 | 33 | 53153 | 75118 | 56163763 |
Fibromyalgia | 12.73 | 12.04 | 23 | 53163 | 59580 | 56179301 |
Gastrointestinal necrosis | 12.71 | 12.04 | 14 | 53172 | 2612 | 56236269 |
Tubal rupture | 12.71 | 12.04 | 3 | 53183 | 14 | 56238867 |
Basal cell carcinoma | 12.70 | 12.04 | 4 | 53182 | 25217 | 56213664 |
Acute myeloid leukaemia | 12.60 | 12.04 | 40 | 53146 | 16932 | 56221949 |
Acute lymphocytic leukaemia recurrent | 12.44 | 12.04 | 13 | 53173 | 2284 | 56236597 |
Orthostatic hypotension | 12.44 | 12.04 | 8 | 53178 | 33191 | 56205690 |
Pharyngotonsillitis | 12.38 | 12.04 | 5 | 53181 | 164 | 56238717 |
Rhinocerebral mucormycosis | 12.38 | 12.04 | 6 | 53180 | 306 | 56238575 |
Blood phosphorus decreased | 12.35 | 12.04 | 17 | 53169 | 3980 | 56234901 |
Obesity | 12.35 | 12.04 | 3 | 53183 | 22445 | 56216436 |
Visual impairment | 12.25 | 12.04 | 33 | 53153 | 74169 | 56164712 |
Hypertensive crisis | 12.23 | 12.04 | 35 | 53151 | 14001 | 56224880 |
Prescribed overdose | 12.22 | 12.04 | 3 | 53183 | 22293 | 56216588 |
Metastases to bone marrow | 12.18 | 12.04 | 6 | 53180 | 317 | 56238564 |
Granulomatous liver disease | 12.16 | 12.04 | 8 | 53178 | 736 | 56238145 |
Gait inability | 12.07 | 12.04 | 13 | 53173 | 41805 | 56197076 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neutropenia | 966.63 | 12.65 | 1259 | 59162 | 139105 | 31497818 |
Skin toxicity | 635.04 | 12.65 | 254 | 60167 | 3905 | 31633018 |
Neuropathy peripheral | 620.68 | 12.65 | 742 | 59679 | 74907 | 31562016 |
Diarrhoea | 497.09 | 12.65 | 1633 | 58788 | 350776 | 31286147 |
Mucosal inflammation | 402.31 | 12.65 | 407 | 60014 | 34020 | 31602903 |
Neurotoxicity | 392.80 | 12.65 | 291 | 60130 | 15935 | 31620988 |
Dermatitis acneiform | 377.04 | 12.65 | 195 | 60226 | 5572 | 31631351 |
Disease progression | 364.37 | 12.65 | 633 | 59788 | 89831 | 31547092 |
Metastases to liver | 332.39 | 12.65 | 239 | 60182 | 12488 | 31624435 |
Colorectal cancer metastatic | 314.37 | 12.65 | 109 | 60312 | 1093 | 31635830 |
Thrombocytopenia | 304.09 | 12.65 | 769 | 59652 | 141978 | 31494945 |
Stomatitis | 303.58 | 12.65 | 375 | 60046 | 39063 | 31597860 |
Palmar-plantar erythrodysaesthesia syndrome | 303.42 | 12.65 | 245 | 60176 | 15238 | 31621685 |
Polyneuropathy | 246.58 | 12.65 | 202 | 60219 | 12820 | 31624103 |
Arteriospasm coronary | 207.11 | 12.65 | 104 | 60317 | 2787 | 31634136 |
Gastrointestinal toxicity | 190.42 | 12.65 | 91 | 60330 | 2183 | 31634740 |
Paronychia | 182.55 | 12.65 | 99 | 60322 | 3119 | 31633804 |
Haematotoxicity | 179.41 | 12.65 | 131 | 60290 | 7006 | 31629917 |
Skin reaction | 169.19 | 12.65 | 108 | 60313 | 4626 | 31632297 |
Proteinuria | 154.71 | 12.65 | 175 | 60246 | 16588 | 31620335 |
Febrile neutropenia | 153.77 | 12.65 | 546 | 59875 | 121303 | 31515620 |
Completed suicide | 151.92 | 12.65 | 5 | 60416 | 91509 | 31545414 |
Leukopenia | 145.80 | 12.65 | 333 | 60088 | 57495 | 31579428 |
Product dose omission issue | 135.36 | 12.65 | 20 | 60401 | 105566 | 31531357 |
Portal hypertension | 120.89 | 12.65 | 80 | 60341 | 3645 | 31633278 |
Metastases to lung | 117.83 | 12.65 | 110 | 60311 | 8312 | 31628611 |
Pyrexia | 117.02 | 12.65 | 982 | 59439 | 302858 | 31334065 |
Nausea | 111.61 | 12.65 | 982 | 59439 | 306965 | 31329958 |
Therapy partial responder | 110.18 | 12.65 | 95 | 60326 | 6467 | 31630456 |
Cardiotoxicity | 110.16 | 12.65 | 85 | 60336 | 4942 | 31631981 |
Drug abuse | 109.34 | 12.65 | 18 | 60403 | 87740 | 31549183 |
Chills | 109.06 | 12.65 | 350 | 60071 | 73800 | 31563123 |
Bone marrow failure | 107.29 | 12.65 | 192 | 60229 | 27816 | 31609107 |
Decreased appetite | 107.24 | 12.65 | 575 | 59846 | 152642 | 31484281 |
Vomiting | 106.14 | 12.65 | 760 | 59661 | 223213 | 31413710 |
Peripheral sensory neuropathy | 105.17 | 12.65 | 91 | 60330 | 6224 | 31630699 |
Cardiac failure congestive | 101.81 | 12.65 | 15 | 60406 | 79372 | 31557551 |
Myelosuppression | 100.69 | 12.65 | 133 | 60288 | 14787 | 31622136 |
Carcinoembryonic antigen increased | 100.35 | 12.65 | 40 | 60381 | 608 | 31636315 |
Rash pustular | 98.36 | 12.65 | 79 | 60342 | 4870 | 31632053 |
Hyperammonaemia | 97.03 | 12.65 | 84 | 60337 | 5749 | 31631174 |
Neoplasm progression | 94.92 | 12.65 | 152 | 60269 | 20120 | 31616803 |
Alopecia | 92.58 | 12.65 | 152 | 60269 | 20543 | 31616380 |
Plasma cell myeloma | 87.49 | 12.65 | 5 | 60416 | 56526 | 31580397 |
General physical health deterioration | 87.11 | 12.65 | 437 | 59984 | 112998 | 31523925 |
Drug interaction | 83.55 | 12.65 | 170 | 60251 | 208373 | 31428550 |
Rhabdomyolysis | 81.55 | 12.65 | 12 | 60409 | 63569 | 31573354 |
Intestinal obstruction | 81.13 | 12.65 | 143 | 60278 | 20467 | 31616456 |
Abdominal pain | 80.81 | 12.65 | 515 | 59906 | 145437 | 31491486 |
Myalgia | 79.85 | 12.65 | 24 | 60397 | 77234 | 31559689 |
Drug ineffective | 77.31 | 12.65 | 441 | 59980 | 395132 | 31241791 |
Metastases to peritoneum | 75.00 | 12.65 | 44 | 60377 | 1616 | 31635307 |
Hyperammonaemic encephalopathy | 72.70 | 12.65 | 48 | 60373 | 2178 | 31634745 |
Focal nodular hyperplasia | 72.03 | 12.65 | 22 | 60399 | 141 | 31636782 |
Adenocarcinoma of colon | 70.86 | 12.65 | 55 | 60366 | 3225 | 31633698 |
Malignant neoplasm progression | 70.53 | 12.65 | 318 | 60103 | 78680 | 31558243 |
Pulmonary embolism | 70.18 | 12.65 | 325 | 60096 | 81321 | 31555602 |
Gastrointestinal perforation | 70.11 | 12.65 | 57 | 60364 | 3575 | 31633348 |
Pneumonia | 68.61 | 12.65 | 368 | 60053 | 334944 | 31301979 |
Myocardial infarction | 66.36 | 12.65 | 71 | 60350 | 113383 | 31523540 |
Fall | 66.06 | 12.65 | 162 | 60259 | 185927 | 31450996 |
Febrile bone marrow aplasia | 65.81 | 12.65 | 78 | 60343 | 7768 | 31629155 |
Asthma | 65.23 | 12.65 | 4 | 60417 | 42607 | 31594316 |
Insomnia | 64.12 | 12.65 | 52 | 60369 | 94784 | 31542139 |
Ascites | 61.52 | 12.65 | 195 | 60226 | 40818 | 31596105 |
Anxiety | 61.44 | 12.65 | 50 | 60371 | 90983 | 31545940 |
Hypomagnesaemia | 60.98 | 12.65 | 121 | 60300 | 18937 | 31617986 |
Enteritis | 60.25 | 12.65 | 71 | 60350 | 7028 | 31629895 |
Interstitial lung disease | 59.99 | 12.65 | 254 | 60167 | 61149 | 31575774 |
Death | 56.67 | 12.65 | 429 | 59992 | 360140 | 31276783 |
Somnolence | 55.12 | 12.65 | 65 | 60356 | 99380 | 31537543 |
Psoriasis | 55.10 | 12.65 | 11 | 60410 | 46708 | 31590215 |
Headache | 53.99 | 12.65 | 175 | 60246 | 183477 | 31453446 |
Device related infection | 52.76 | 12.65 | 104 | 60317 | 16195 | 31620728 |
Leukoencephalopathy | 52.72 | 12.65 | 50 | 60371 | 3852 | 31633071 |
Colorectal cancer | 52.54 | 12.65 | 55 | 60366 | 4774 | 31632149 |
Small intestinal obstruction | 52.40 | 12.65 | 93 | 60328 | 13379 | 31623544 |
Conjunctivitis | 52.30 | 12.65 | 73 | 60348 | 8550 | 31628373 |
Paraesthesia | 51.74 | 12.65 | 228 | 60193 | 55843 | 31581080 |
Recall phenomenon | 51.62 | 12.65 | 24 | 60397 | 540 | 31636383 |
Mucosal toxicity | 51.14 | 12.65 | 19 | 60402 | 236 | 31636687 |
Drug clearance decreased | 50.71 | 12.65 | 34 | 60387 | 1583 | 31635340 |
Cholangitis | 50.53 | 12.65 | 69 | 60352 | 7917 | 31629006 |
Hospitalisation | 50.50 | 12.65 | 16 | 60405 | 49791 | 31587132 |
Intentional overdose | 50.40 | 12.65 | 9 | 60412 | 41380 | 31595543 |
Coronary artery disease | 50.06 | 12.65 | 13 | 60408 | 46074 | 31590849 |
Transdifferentiation of neoplasm | 49.78 | 12.65 | 14 | 60407 | 64 | 31636859 |
Weight increased | 49.50 | 12.65 | 51 | 60370 | 82896 | 31554027 |
Ileus | 49.36 | 12.65 | 97 | 60324 | 15072 | 31621851 |
Influenza | 49.11 | 12.65 | 12 | 60409 | 44313 | 31592610 |
Hiccups | 48.15 | 12.65 | 73 | 60348 | 9214 | 31627709 |
Aggression | 47.89 | 12.65 | 7 | 60414 | 37284 | 31599639 |
Dizziness | 47.33 | 12.65 | 207 | 60214 | 198940 | 31437983 |
Tumour necrosis | 47.24 | 12.65 | 29 | 60392 | 1158 | 31635765 |
Blood glucose increased | 47.19 | 12.65 | 29 | 60392 | 61054 | 31575869 |
Dehydration | 47.17 | 12.65 | 388 | 60033 | 118723 | 31518200 |
Metastases to lymph nodes | 47.13 | 12.65 | 49 | 60372 | 4219 | 31632704 |
Chronic obstructive pulmonary disease | 46.71 | 12.65 | 14 | 60407 | 45152 | 31591771 |
Anastomotic leak | 46.53 | 12.65 | 23 | 60398 | 595 | 31636328 |
Subileus | 45.61 | 12.65 | 41 | 60380 | 2949 | 31633974 |
Peripheral swelling | 44.88 | 12.65 | 38 | 60383 | 67827 | 31569096 |
Neoplasm recurrence | 44.70 | 12.65 | 35 | 60386 | 2079 | 31634844 |
Subclavian vein thrombosis | 44.57 | 12.65 | 25 | 60396 | 842 | 31636081 |
Rectal tenesmus | 44.42 | 12.65 | 24 | 60397 | 750 | 31636173 |
Bradycardia | 44.42 | 12.65 | 40 | 60381 | 69287 | 31567636 |
Arthralgia | 43.99 | 12.65 | 145 | 60276 | 151279 | 31485644 |
Peripheral sensorimotor neuropathy | 43.97 | 12.65 | 30 | 60391 | 1438 | 31635485 |
Erythema | 43.96 | 12.65 | 283 | 60138 | 80122 | 31556801 |
Carbohydrate antigen 19-9 increased | 43.94 | 12.65 | 16 | 60405 | 187 | 31636736 |
Injection site pain | 43.34 | 12.65 | 7 | 60414 | 34627 | 31602296 |
Febrile infection | 43.30 | 12.65 | 34 | 60387 | 2028 | 31634895 |
Colon cancer metastatic | 43.17 | 12.65 | 31 | 60390 | 1614 | 31635309 |
Proteus infection | 42.69 | 12.65 | 25 | 60396 | 915 | 31636008 |
Intravascular haemolysis | 42.32 | 12.65 | 19 | 60402 | 393 | 31636530 |
Feeling abnormal | 41.40 | 12.65 | 29 | 60392 | 56973 | 31579950 |
Anastomotic complication | 40.79 | 12.65 | 18 | 60403 | 357 | 31636566 |
Depression | 40.73 | 12.65 | 69 | 60352 | 90746 | 31546177 |
Ileal perforation | 40.59 | 12.65 | 22 | 60399 | 692 | 31636231 |
Tumour lysis syndrome | 40.28 | 12.65 | 90 | 60331 | 15295 | 31621628 |
Administration site extravasation | 39.78 | 12.65 | 20 | 60401 | 537 | 31636386 |
Intentional product misuse | 38.81 | 12.65 | 12 | 60409 | 37939 | 31598984 |
Sinusitis | 38.63 | 12.65 | 11 | 60410 | 36685 | 31600238 |
Type II hypersensitivity | 38.60 | 12.65 | 10 | 60411 | 31 | 31636892 |
Pain in extremity | 38.24 | 12.65 | 105 | 60316 | 116098 | 31520825 |
Suicidal ideation | 38.16 | 12.65 | 11 | 60410 | 36395 | 31600528 |
Epistaxis | 37.74 | 12.65 | 202 | 60219 | 53505 | 31583418 |
Nicotinic acid deficiency | 37.10 | 12.65 | 12 | 60409 | 95 | 31636828 |
Hypersensitivity | 36.72 | 12.65 | 206 | 60215 | 55537 | 31581386 |
Unevaluable event | 36.47 | 12.65 | 7 | 60414 | 30568 | 31606355 |
Hallucination | 35.89 | 12.65 | 22 | 60399 | 46388 | 31590535 |
Pelvic abscess | 35.74 | 12.65 | 22 | 60399 | 883 | 31636040 |
Wheezing | 35.70 | 12.65 | 12 | 60409 | 35974 | 31600949 |
Cellulitis | 35.44 | 12.65 | 24 | 60397 | 47994 | 31588929 |
Muscle spasms | 35.39 | 12.65 | 47 | 60374 | 68271 | 31568652 |
Intestinal perforation | 35.35 | 12.65 | 60 | 60361 | 8329 | 31628594 |
Colon cancer recurrent | 34.90 | 12.65 | 12 | 60409 | 117 | 31636806 |
Pneumatosis intestinalis | 34.66 | 12.65 | 39 | 60382 | 3672 | 31633251 |
Contusion | 34.58 | 12.65 | 10 | 60411 | 33018 | 31603905 |
Hypoglycaemia | 34.33 | 12.65 | 28 | 60393 | 50918 | 31586005 |
Asthenia | 34.24 | 12.65 | 610 | 59811 | 224145 | 31412778 |
Adverse drug reaction | 34.11 | 12.65 | 4 | 60417 | 25197 | 31611726 |
Necrotising fasciitis | 33.18 | 12.65 | 37 | 60384 | 3449 | 31633474 |
Colitis | 32.93 | 12.65 | 140 | 60281 | 33747 | 31603176 |
Foetal disorder | 32.77 | 12.65 | 20 | 60401 | 790 | 31636133 |
Anal haemorrhage | 32.70 | 12.65 | 31 | 60390 | 2387 | 31634536 |
Treatment noncompliance | 32.57 | 12.65 | 5 | 60416 | 25679 | 31611244 |
Jugular vein thrombosis | 32.40 | 12.65 | 25 | 60396 | 1453 | 31635470 |
Vena cava thrombosis | 32.31 | 12.65 | 22 | 60399 | 1051 | 31635872 |
Anaemia of malignant disease | 31.64 | 12.65 | 16 | 60405 | 435 | 31636488 |
Colitis microscopic | 31.53 | 12.65 | 28 | 60393 | 1982 | 31634941 |
Hyperbilirubinaemia | 31.45 | 12.65 | 83 | 60338 | 15667 | 31621256 |
Portal vein thrombosis | 31.30 | 12.65 | 36 | 60385 | 3471 | 31633452 |
Blood creatine phosphokinase increased | 30.95 | 12.65 | 21 | 60400 | 41953 | 31594970 |
Induration | 30.52 | 12.65 | 20 | 60401 | 896 | 31636027 |
Cholinergic syndrome | 30.09 | 12.65 | 16 | 60405 | 484 | 31636439 |
Vascular access complication | 29.99 | 12.65 | 14 | 60407 | 318 | 31636605 |
Venoocclusive liver disease | 29.90 | 12.65 | 52 | 60369 | 7360 | 31629563 |
Rectal adenocarcinoma | 29.79 | 12.65 | 19 | 60402 | 812 | 31636111 |
Prothrombin level decreased | 29.78 | 12.65 | 21 | 60400 | 1062 | 31635861 |
Proctalgia | 29.75 | 12.65 | 40 | 60381 | 4522 | 31632401 |
Confusional state | 29.60 | 12.65 | 142 | 60279 | 133192 | 31503731 |
Acute coronary syndrome | 29.30 | 12.65 | 71 | 60350 | 12718 | 31624205 |
Peritonitis | 28.82 | 12.65 | 79 | 60342 | 15248 | 31621675 |
Intentional product use issue | 28.69 | 12.65 | 31 | 60390 | 49316 | 31587607 |
Wrong technique in product usage process | 28.40 | 12.65 | 14 | 60407 | 33329 | 31603594 |
Hypokalaemia | 28.31 | 12.65 | 187 | 60234 | 53387 | 31583536 |
Memory impairment | 28.22 | 12.65 | 19 | 60402 | 38111 | 31598812 |
Neutropenia neonatal | 28.03 | 12.65 | 17 | 60404 | 664 | 31636259 |
Electrocardiogram QT prolonged | 28.01 | 12.65 | 19 | 60402 | 37968 | 31598955 |
Circulatory collapse | 27.89 | 12.65 | 92 | 60329 | 19652 | 31617271 |
Pulmonary infarction | 27.76 | 12.65 | 21 | 60400 | 1185 | 31635738 |
Sarcoidosis | 27.68 | 12.65 | 30 | 60391 | 2709 | 31634214 |
Electrocardiogram ST segment elevation | 27.65 | 12.65 | 39 | 60382 | 4612 | 31632311 |
Overdose | 27.47 | 12.65 | 77 | 60344 | 84587 | 31552336 |
Abdominal pain lower | 27.41 | 12.65 | 57 | 60364 | 9219 | 31627704 |
Small intestinal perforation | 27.38 | 12.65 | 26 | 60395 | 2006 | 31634917 |
Hypoalbuminaemia | 27.18 | 12.65 | 63 | 60358 | 10965 | 31625958 |
Disturbance in attention | 27.07 | 12.65 | 5 | 60416 | 22445 | 31614478 |
Injury | 27.00 | 12.65 | 3 | 60418 | 19706 | 31617217 |
Splenomegaly | 26.99 | 12.65 | 72 | 60349 | 13677 | 31623246 |
Anal fissure | 26.97 | 12.65 | 33 | 60388 | 3396 | 31633527 |
Fluid retention | 26.92 | 12.65 | 7 | 60414 | 24795 | 31612128 |
Onycholysis | 26.75 | 12.65 | 16 | 60405 | 609 | 31636314 |
Perihepatic abscess | 26.43 | 12.65 | 9 | 60412 | 85 | 31636838 |
Koebner phenomenon | 26.36 | 12.65 | 8 | 60413 | 50 | 31636873 |
Anaemia | 26.22 | 12.65 | 561 | 59860 | 212961 | 31423962 |
Evans syndrome | 26.14 | 12.65 | 12 | 60409 | 262 | 31636661 |
Toxic erythema of chemotherapy | 25.97 | 12.65 | 9 | 60412 | 90 | 31636833 |
Cardiac disorder | 25.86 | 12.65 | 22 | 60399 | 39192 | 31597731 |
Catheter site thrombosis | 25.71 | 12.65 | 8 | 60413 | 55 | 31636868 |
Rheumatoid arthritis | 25.67 | 12.65 | 32 | 60389 | 47777 | 31589146 |
Dyspnoea | 25.66 | 12.65 | 481 | 59940 | 342998 | 31293925 |
Cerebral vasoconstriction | 25.50 | 12.65 | 11 | 60410 | 206 | 31636717 |
Perforation | 25.45 | 12.65 | 11 | 60410 | 207 | 31636716 |
Sleep apnoea syndrome | 25.10 | 12.65 | 3 | 60418 | 18622 | 31618301 |
Ocular toxicity | 25.07 | 12.65 | 11 | 60410 | 215 | 31636708 |
Large intestine perforation | 25.04 | 12.65 | 49 | 60372 | 7587 | 31629336 |
Prostate cancer | 24.92 | 12.65 | 21 | 60400 | 37580 | 31599343 |
Enterovesical fistula | 24.77 | 12.65 | 16 | 60405 | 699 | 31636224 |
Cerebrovascular accident | 24.53 | 12.65 | 74 | 60347 | 79410 | 31557513 |
Oesophagobronchial fistula | 24.51 | 12.65 | 10 | 60411 | 162 | 31636761 |
Product prescribing error | 24.51 | 12.65 | 4 | 60417 | 19638 | 31617285 |
Liver function test abnormal | 24.49 | 12.65 | 13 | 60408 | 29679 | 31607244 |
Enterocutaneous fistula | 24.40 | 12.65 | 17 | 60404 | 843 | 31636080 |
Influenza like illness | 24.34 | 12.65 | 9 | 60412 | 25428 | 31611495 |
Adenocarcinoma | 24.29 | 12.65 | 23 | 60398 | 1768 | 31635155 |
Perioral dermatitis | 24.14 | 12.65 | 9 | 60412 | 113 | 31636810 |
Interventricular septum rupture | 24.10 | 12.65 | 6 | 60415 | 15 | 31636908 |
Seizure | 24.08 | 12.65 | 103 | 60318 | 99665 | 31537258 |
Peritoneal neoplasm | 23.90 | 12.65 | 7 | 60414 | 38 | 31636885 |
Clostridial infection | 23.90 | 12.65 | 31 | 60390 | 3384 | 31633539 |
Rectal cancer metastatic | 23.84 | 12.65 | 11 | 60410 | 243 | 31636680 |
Rectal cancer | 23.82 | 12.65 | 25 | 60396 | 2176 | 31634747 |
Pulmonary oedema | 23.67 | 12.65 | 30 | 60391 | 44472 | 31592451 |
Stoma site haemorrhage | 23.65 | 12.65 | 16 | 60405 | 756 | 31636167 |
Astringent therapy | 23.56 | 12.65 | 6 | 60415 | 17 | 31636906 |
ECG signs of myocardial ischaemia | 23.25 | 12.65 | 10 | 60411 | 186 | 31636737 |
Superior vena cava syndrome | 23.19 | 12.65 | 14 | 60407 | 542 | 31636381 |
Nail disorder | 23.19 | 12.65 | 23 | 60398 | 1872 | 31635051 |
Rectal perforation | 23.14 | 12.65 | 13 | 60408 | 439 | 31636484 |
Productive cough | 23.14 | 12.65 | 18 | 60403 | 33522 | 31603401 |
Embolism | 23.13 | 12.65 | 46 | 60375 | 7207 | 31629716 |
Anal erythema | 22.74 | 12.65 | 8 | 60413 | 84 | 31636839 |
Stoma site pain | 22.67 | 12.65 | 14 | 60407 | 565 | 31636358 |
Pelvic fluid collection | 22.63 | 12.65 | 9 | 60412 | 136 | 31636787 |
Pancreatic carcinoma metastatic | 22.62 | 12.65 | 28 | 60393 | 2916 | 31634007 |
International normalised ratio increased | 22.52 | 12.65 | 32 | 60389 | 45191 | 31591732 |
Incorrect dose administered | 22.45 | 12.65 | 21 | 60400 | 35731 | 31601192 |
Oesophagitis | 22.36 | 12.65 | 63 | 60358 | 12353 | 31624570 |
Acute abdomen | 22.30 | 12.65 | 22 | 60399 | 1779 | 31635144 |
Device related thrombosis | 22.18 | 12.65 | 17 | 60404 | 978 | 31635945 |
Pneumoperitoneum | 22.10 | 12.65 | 21 | 60400 | 1622 | 31635301 |
Product use issue | 22.04 | 12.65 | 47 | 60374 | 56712 | 31580211 |
Perforation bile duct | 21.98 | 12.65 | 6 | 60415 | 24 | 31636899 |
Trichomegaly | 21.78 | 12.65 | 6 | 60415 | 25 | 31636898 |
Mucocutaneous rash | 21.78 | 12.65 | 6 | 60415 | 25 | 31636898 |
Liver abscess | 21.44 | 12.65 | 30 | 60391 | 3521 | 31633402 |
Sedation | 21.27 | 12.65 | 5 | 60416 | 18960 | 31617963 |
Full blood count abnormal | 21.15 | 12.65 | 3 | 60418 | 16344 | 31620579 |
Oesophageal haemorrhage | 21.13 | 12.65 | 18 | 60403 | 1205 | 31635718 |
Pulmonary artery thrombosis | 20.99 | 12.65 | 14 | 60407 | 646 | 31636277 |
Haematopoietic stem cell mobilisation | 20.99 | 12.65 | 9 | 60412 | 166 | 31636757 |
Lung neoplasm malignant | 20.94 | 12.65 | 3 | 60418 | 16227 | 31620696 |
Nipple swelling | 20.93 | 12.65 | 8 | 60413 | 108 | 31636815 |
Respiratory arrest | 20.93 | 12.65 | 12 | 60409 | 26245 | 31610678 |
Agitation | 20.91 | 12.65 | 45 | 60376 | 54124 | 31582799 |
Ischiorectal hernia | 20.85 | 12.65 | 5 | 60416 | 10 | 31636913 |
Chronic kidney disease | 20.83 | 12.65 | 25 | 60396 | 37950 | 31598973 |
Angioedema | 20.81 | 12.65 | 20 | 60401 | 33598 | 31603325 |
Cranial nerve disorder | 20.74 | 12.65 | 13 | 60408 | 539 | 31636384 |
Skin fissures | 20.71 | 12.65 | 33 | 60388 | 4347 | 31632576 |
Contraindicated product administered | 20.67 | 12.65 | 6 | 60415 | 19766 | 31617157 |
Nephrotic syndrome | 20.66 | 12.65 | 43 | 60378 | 6960 | 31629963 |
Onychoclasis | 20.53 | 12.65 | 21 | 60400 | 1774 | 31635149 |
Mouth ulceration | 20.48 | 12.65 | 56 | 60365 | 10792 | 31626131 |
Portal venous gas | 20.35 | 12.65 | 11 | 60410 | 344 | 31636579 |
Aplasia | 20.33 | 12.65 | 32 | 60389 | 4171 | 31632752 |
Non-cirrhotic portal hypertension | 20.33 | 12.65 | 10 | 60411 | 256 | 31636667 |
Hepatectomy | 20.29 | 12.65 | 7 | 60414 | 69 | 31636854 |
Cardiac arrest | 20.25 | 12.65 | 94 | 60327 | 88968 | 31547955 |
Neurosarcoidosis | 20.14 | 12.65 | 9 | 60412 | 184 | 31636739 |
Organising pneumonia | 20.10 | 12.65 | 37 | 60384 | 5473 | 31631450 |
Hepatic lesion | 20.08 | 12.65 | 28 | 60393 | 3275 | 31633648 |
Thrombotic thrombocytopenic purpura | 20.02 | 12.65 | 28 | 60393 | 3285 | 31633638 |
Deep vein thrombosis | 19.94 | 12.65 | 190 | 60231 | 60546 | 31576377 |
Eyelash changes | 19.94 | 12.65 | 5 | 60416 | 13 | 31636910 |
Cholecystitis chronic | 19.82 | 12.65 | 15 | 60406 | 847 | 31636076 |
Arthritis | 19.79 | 12.65 | 14 | 60407 | 27371 | 31609552 |
Acne | 19.73 | 12.65 | 53 | 60368 | 10107 | 31626816 |
Klebsiella infection | 19.70 | 12.65 | 45 | 60376 | 7758 | 31629165 |
Cachexia | 19.69 | 12.65 | 41 | 60380 | 6638 | 31630285 |
Varices oesophageal | 19.68 | 12.65 | 28 | 60393 | 3338 | 31633585 |
Acute motor-sensory axonal neuropathy | 19.58 | 12.65 | 8 | 60413 | 130 | 31636793 |
Visceral venous thrombosis | 19.42 | 12.65 | 5 | 60416 | 15 | 31636908 |
Allodynia | 19.38 | 12.65 | 13 | 60408 | 606 | 31636317 |
Hepatitis B surface antigen positive | 19.36 | 12.65 | 8 | 60413 | 134 | 31636789 |
Dysaesthesia | 19.33 | 12.65 | 22 | 60399 | 2097 | 31634826 |
Haematoma | 19.28 | 12.65 | 11 | 60410 | 24128 | 31612795 |
Product administration error | 19.26 | 12.65 | 3 | 60418 | 15244 | 31621679 |
K-ras gene mutation | 19.18 | 12.65 | 5 | 60416 | 16 | 31636907 |
Anastomotic fistula | 19.06 | 12.65 | 7 | 60414 | 84 | 31636839 |
Neck pain | 18.94 | 12.65 | 10 | 60411 | 22900 | 31614023 |
Venous thrombosis | 18.91 | 12.65 | 27 | 60394 | 3228 | 31633695 |
Xerosis | 18.90 | 12.65 | 12 | 60409 | 509 | 31636414 |
Abnormal behaviour | 18.83 | 12.65 | 11 | 60410 | 23817 | 31613106 |
Catheter site extravasation | 18.76 | 12.65 | 7 | 60414 | 88 | 31636835 |
Cerebral haemorrhage | 18.64 | 12.65 | 21 | 60400 | 32791 | 31604132 |
Heart rate increased | 18.63 | 12.65 | 31 | 60390 | 41079 | 31595844 |
Multiple organ dysfunction syndrome | 18.63 | 12.65 | 67 | 60354 | 68136 | 31568787 |
Renal disorder | 18.57 | 12.65 | 11 | 60410 | 23634 | 31613289 |
Balanoposthitis | 18.50 | 12.65 | 16 | 60405 | 1093 | 31635830 |
Off label use | 18.38 | 12.65 | 823 | 59598 | 346451 | 31290472 |
Bladder cancer | 18.37 | 12.65 | 3 | 60418 | 14722 | 31622201 |
Bacterial colitis | 18.18 | 12.65 | 6 | 60415 | 51 | 31636872 |
Pseudocirrhosis | 18.12 | 12.65 | 5 | 60416 | 21 | 31636902 |
Performance status decreased | 18.04 | 12.65 | 29 | 60392 | 3849 | 31633074 |
Oral pain | 18.03 | 12.65 | 50 | 60371 | 9715 | 31627208 |
Rectal abscess | 17.96 | 12.65 | 15 | 60406 | 977 | 31635946 |
Rectosigmoid cancer | 17.89 | 12.65 | 8 | 60413 | 164 | 31636759 |
Fatigue | 17.87 | 12.65 | 795 | 59626 | 334411 | 31302512 |
Electromyogram abnormal | 17.78 | 12.65 | 6 | 60415 | 55 | 31636868 |
B-cell small lymphocytic lymphoma | 17.75 | 12.65 | 8 | 60413 | 167 | 31636756 |
Emotional distress | 17.74 | 12.65 | 3 | 60418 | 14353 | 31622570 |
Red blood cell sedimentation rate abnormal | 17.46 | 12.65 | 25 | 60396 | 2997 | 31633926 |
Urticaria | 17.42 | 12.65 | 54 | 60367 | 57463 | 31579460 |
Eczema impetiginous | 17.41 | 12.65 | 5 | 60416 | 25 | 31636898 |
Radiation interaction | 17.41 | 12.65 | 5 | 60416 | 25 | 31636898 |
Pelvic inflammatory disease | 17.41 | 12.65 | 4 | 60417 | 6 | 31636917 |
Posterior reversible encephalopathy syndrome | 17.33 | 12.65 | 48 | 60373 | 9319 | 31627604 |
Streptococcal bacteraemia | 17.30 | 12.65 | 19 | 60402 | 1741 | 31635182 |
Candida infection | 17.23 | 12.65 | 69 | 60352 | 16189 | 31620734 |
Perineal disorder | 17.14 | 12.65 | 6 | 60415 | 62 | 31636861 |
Gastrointestinal haemorrhage | 17.11 | 12.65 | 90 | 60331 | 82459 | 31554464 |
Organic brain syndrome | 17.08 | 12.65 | 9 | 60412 | 267 | 31636656 |
Haemolytic anaemia | 16.95 | 12.65 | 49 | 60372 | 9747 | 31627176 |
Dysphonia | 16.95 | 12.65 | 81 | 60340 | 20510 | 31616413 |
Soft tissue swelling | 16.90 | 12.65 | 10 | 60411 | 373 | 31636550 |
Haemorrhage intracranial | 16.88 | 12.65 | 4 | 60417 | 15084 | 31621839 |
Bronchitis | 16.81 | 12.65 | 30 | 60391 | 38687 | 31598236 |
Crystal nephropathy | 16.81 | 12.65 | 10 | 60411 | 377 | 31636546 |
Faeces discoloured | 16.77 | 12.65 | 3 | 60418 | 13783 | 31623140 |
Metastasis | 16.72 | 12.65 | 27 | 60394 | 3597 | 31633326 |
Neutrophil count decreased | 16.68 | 12.65 | 148 | 60273 | 46246 | 31590677 |
Oesophageal irritation | 16.64 | 12.65 | 6 | 60415 | 68 | 31636855 |
Psychotic disorder | 16.64 | 12.65 | 11 | 60410 | 22282 | 31614641 |
Hypervolaemia | 16.57 | 12.65 | 7 | 60414 | 18244 | 31618679 |
Intestinal strangulation | 16.51 | 12.65 | 5 | 60416 | 31 | 31636892 |
Vocal cord paralysis | 16.51 | 12.65 | 14 | 60407 | 931 | 31635992 |
Malignant ascites | 16.34 | 12.65 | 10 | 60411 | 397 | 31636526 |
Proctitis | 16.31 | 12.65 | 21 | 60400 | 2276 | 31634647 |
Brief psychotic disorder with marked stressors | 16.29 | 12.65 | 8 | 60413 | 204 | 31636719 |
Hepatic cancer recurrent | 16.16 | 12.65 | 9 | 60412 | 299 | 31636624 |
Irritability | 16.15 | 12.65 | 12 | 60409 | 22877 | 31614046 |
Tumour fistulisation | 16.07 | 12.65 | 4 | 60417 | 10 | 31636913 |
Medication error | 15.99 | 12.65 | 12 | 60409 | 22760 | 31614163 |
Drug ineffective for unapproved indication | 15.87 | 12.65 | 7 | 60414 | 17783 | 31619140 |
Gastrooesophageal reflux disease | 15.86 | 12.65 | 25 | 60396 | 33846 | 31603077 |
Injection site erythema | 15.85 | 12.65 | 4 | 60417 | 14458 | 31622465 |
Sepsis | 15.76 | 12.65 | 390 | 60031 | 151539 | 31485384 |
Gene mutation | 15.73 | 12.65 | 15 | 60406 | 1163 | 31635760 |
Change of bowel habit | 15.69 | 12.65 | 14 | 60407 | 997 | 31635926 |
Limbic encephalitis | 15.69 | 12.65 | 10 | 60411 | 427 | 31636496 |
Laboratory test interference | 15.60 | 12.65 | 10 | 60411 | 431 | 31636492 |
Temperature difference of extremities | 15.54 | 12.65 | 4 | 60417 | 12 | 31636911 |
Portal shunt | 15.52 | 12.65 | 5 | 60416 | 39 | 31636884 |
Hypertension | 15.50 | 12.65 | 336 | 60085 | 127764 | 31509159 |
Tremor | 15.46 | 12.65 | 84 | 60337 | 76336 | 31560587 |
Colorectal cancer recurrent | 15.41 | 12.65 | 5 | 60416 | 40 | 31636883 |
Tumour marker increased | 15.41 | 12.65 | 11 | 60410 | 567 | 31636356 |
Dry skin | 15.35 | 12.65 | 92 | 60329 | 25389 | 31611534 |
Road traffic accident | 15.33 | 12.65 | 6 | 60415 | 16375 | 31620548 |
Folliculitis | 15.32 | 12.65 | 28 | 60393 | 4120 | 31632803 |
Duodenal perforation | 15.16 | 12.65 | 15 | 60406 | 1217 | 31635706 |
Mobility decreased | 15.15 | 12.65 | 18 | 60403 | 27451 | 31609472 |
Retinitis viral | 15.12 | 12.65 | 6 | 60415 | 90 | 31636833 |
Retroperitoneal abscess | 15.12 | 12.65 | 7 | 60414 | 156 | 31636767 |
Oedema | 15.10 | 12.65 | 37 | 60384 | 42524 | 31594399 |
Heart rate decreased | 15.09 | 12.65 | 19 | 60402 | 28247 | 31608676 |
Cardiac failure | 15.00 | 12.65 | 99 | 60322 | 85854 | 31551069 |
Ductal adenocarcinoma of pancreas | 15.00 | 12.65 | 5 | 60416 | 44 | 31636879 |
Gout | 14.92 | 12.65 | 8 | 60413 | 18166 | 31618757 |
Joint ankylosis | 14.90 | 12.65 | 14 | 60407 | 1066 | 31635857 |
Therapy non-responder | 14.86 | 12.65 | 26 | 60395 | 33785 | 31603138 |
Toxicity to various agents | 14.82 | 12.65 | 250 | 60171 | 181237 | 31455686 |
Acinetobacter sepsis | 14.80 | 12.65 | 5 | 60416 | 46 | 31636877 |
Ventricular tachycardia | 14.79 | 12.65 | 14 | 60407 | 23687 | 31613236 |
Bladder hypertrophy | 14.79 | 12.65 | 11 | 60410 | 605 | 31636318 |
Blood pressure increased | 14.78 | 12.65 | 90 | 60331 | 79543 | 31557380 |
Dyskinesia | 14.70 | 12.65 | 11 | 60410 | 20899 | 31616024 |
Oesophageal carcinoma recurrent | 14.65 | 12.65 | 4 | 60417 | 16 | 31636907 |
Paraesthesia mucosal | 14.65 | 12.65 | 4 | 60417 | 16 | 31636907 |
Gastrointestinal anastomotic leak | 14.58 | 12.65 | 9 | 60412 | 363 | 31636560 |
Hypersplenism | 14.58 | 12.65 | 9 | 60412 | 363 | 31636560 |
Stomal hernia | 14.53 | 12.65 | 7 | 60414 | 171 | 31636752 |
Balance disorder | 14.51 | 12.65 | 31 | 60390 | 37391 | 31599532 |
Diffuse alveolar damage | 14.46 | 12.65 | 19 | 60402 | 2100 | 31634823 |
Fistula | 14.45 | 12.65 | 33 | 60388 | 5688 | 31631235 |
Prostatic calcification | 14.44 | 12.65 | 6 | 60415 | 102 | 31636821 |
Laryngospasm | 14.34 | 12.65 | 15 | 60406 | 1301 | 31635622 |
Nasopharyngitis | 14.22 | 12.65 | 67 | 60354 | 63178 | 31573745 |
Peritoneal disorder | 14.19 | 12.65 | 8 | 60413 | 272 | 31636651 |
Rectal cancer recurrent | 14.10 | 12.65 | 4 | 60417 | 19 | 31636904 |
Palmar erythema | 14.09 | 12.65 | 8 | 60413 | 276 | 31636647 |
Bone cyst | 14.04 | 12.65 | 14 | 60407 | 1147 | 31635776 |
Drug clearance increased | 14.03 | 12.65 | 6 | 60415 | 110 | 31636813 |
Nightmare | 14.01 | 12.65 | 3 | 60418 | 12134 | 31624789 |
Lip swelling | 14.01 | 12.65 | 4 | 60417 | 13319 | 31623604 |
Hyperkalaemia | 13.99 | 12.65 | 69 | 60352 | 64282 | 31572641 |
Blood pressure decreased | 13.97 | 12.65 | 46 | 60375 | 48045 | 31588878 |
Metastases to pelvis | 13.93 | 12.65 | 8 | 60413 | 282 | 31636641 |
Incorrect drug administration rate | 13.84 | 12.65 | 15 | 60406 | 1355 | 31635568 |
Renal impairment | 13.82 | 12.65 | 102 | 60319 | 86247 | 31550676 |
Jaundice | 13.80 | 12.65 | 102 | 60319 | 30185 | 31606738 |
Malaise | 13.79 | 12.65 | 232 | 60189 | 168279 | 31468644 |
VIth nerve disorder | 13.77 | 12.65 | 4 | 60417 | 21 | 31636902 |
Pancreatic carcinoma recurrent | 13.77 | 12.65 | 5 | 60416 | 58 | 31636865 |
Hypocalcaemia | 13.66 | 12.65 | 80 | 60341 | 21898 | 31615025 |
Bacteriuria | 13.63 | 12.65 | 8 | 60413 | 294 | 31636629 |
Swelling | 13.63 | 12.65 | 32 | 60389 | 37326 | 31599597 |
Gait inability | 13.55 | 12.65 | 10 | 60411 | 19134 | 31617789 |
Polyserositis | 13.49 | 12.65 | 7 | 60414 | 201 | 31636722 |
Colon cancer stage III | 13.49 | 12.65 | 7 | 60414 | 201 | 31636722 |
Iatrogenic infection | 13.47 | 12.65 | 5 | 60416 | 62 | 31636861 |
Toxic leukoencephalopathy | 13.41 | 12.65 | 8 | 60413 | 303 | 31636620 |
Chemotherapeutic drug level increased | 13.40 | 12.65 | 7 | 60414 | 204 | 31636719 |
Volvulus of small bowel | 13.39 | 12.65 | 5 | 60416 | 63 | 31636860 |
Intestinal mucosal hypertrophy | 13.39 | 12.65 | 5 | 60416 | 63 | 31636860 |
Tracheal inflammation | 13.39 | 12.65 | 5 | 60416 | 63 | 31636860 |
Immune thrombocytopenia | 13.28 | 12.65 | 41 | 60380 | 8457 | 31628466 |
Neuropathic muscular atrophy | 13.18 | 12.65 | 4 | 60417 | 25 | 31636898 |
Pleural fistula | 13.18 | 12.65 | 4 | 60417 | 25 | 31636898 |
Rectal discharge | 13.15 | 12.65 | 7 | 60414 | 212 | 31636711 |
Obstruction gastric | 13.15 | 12.65 | 12 | 60409 | 880 | 31636043 |
Peritoneal adhesions | 13.11 | 12.65 | 6 | 60415 | 130 | 31636793 |
Eosinophilia | 13.08 | 12.65 | 15 | 60406 | 23238 | 31613685 |
Electric shock | 12.94 | 12.65 | 6 | 60415 | 134 | 31636789 |
COVID-19 pneumonia | 12.94 | 12.65 | 4 | 60417 | 12651 | 31624272 |
Visual impairment | 12.90 | 12.65 | 25 | 60396 | 31254 | 31605669 |
Adverse event | 12.80 | 12.65 | 8 | 60413 | 16697 | 31620226 |
Splenic abscess | 12.75 | 12.65 | 8 | 60413 | 332 | 31636591 |
Toxoplasmosis | 12.75 | 12.65 | 14 | 60407 | 1283 | 31635640 |
Pneumonia aspiration | 12.71 | 12.65 | 35 | 60386 | 38691 | 31598232 |
Colitis ulcerative | 12.71 | 12.65 | 10 | 60411 | 18519 | 31618404 |
Gastrointestinal necrosis | 12.66 | 12.65 | 22 | 60399 | 3112 | 31633811 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neutropenia | 1954.86 | 11.17 | 2118 | 100373 | 255038 | 70570915 |
Neuropathy peripheral | 1305.54 | 11.17 | 1233 | 101258 | 125663 | 70700290 |
Skin toxicity | 825.23 | 11.17 | 331 | 102160 | 6867 | 70819086 |
Neurotoxicity | 814.20 | 11.17 | 518 | 101973 | 29308 | 70796645 |
Mucosal inflammation | 775.79 | 11.17 | 700 | 101791 | 67150 | 70758803 |
Disease progression | 741.86 | 11.17 | 1018 | 101473 | 155654 | 70670299 |
Diarrhoea | 705.60 | 11.17 | 2601 | 99890 | 780740 | 70045213 |
Thrombocytopenia | 705.57 | 11.17 | 1249 | 101242 | 237861 | 70588092 |
Dermatitis acneiform | 506.73 | 11.17 | 251 | 102240 | 8694 | 70817259 |
Colorectal cancer metastatic | 444.03 | 11.17 | 146 | 102345 | 1663 | 70824290 |
Polyneuropathy | 405.97 | 11.17 | 297 | 102194 | 21118 | 70804835 |
Febrile neutropenia | 380.20 | 11.17 | 882 | 101609 | 203436 | 70622517 |
Palmar-plantar erythrodysaesthesia syndrome | 365.14 | 11.17 | 322 | 102169 | 29925 | 70796028 |
Metastases to liver | 364.50 | 11.17 | 301 | 102190 | 25577 | 70800376 |
Haematotoxicity | 361.89 | 11.17 | 233 | 102258 | 13441 | 70812512 |
Neoplasm progression | 332.07 | 11.17 | 367 | 102124 | 44861 | 70781092 |
Leukopenia | 329.54 | 11.17 | 569 | 101922 | 105991 | 70719962 |
Arteriospasm coronary | 326.33 | 11.17 | 164 | 102327 | 5860 | 70820093 |
Stomatitis | 321.38 | 11.17 | 626 | 101865 | 127885 | 70698068 |
Completed suicide | 302.80 | 11.17 | 5 | 102486 | 227130 | 70598823 |
Proteinuria | 259.38 | 11.17 | 263 | 102228 | 29111 | 70796842 |
Gastrointestinal toxicity | 246.93 | 11.17 | 139 | 102352 | 6266 | 70819687 |
Bone marrow failure | 224.74 | 11.17 | 314 | 102177 | 48696 | 70777257 |
Myelosuppression | 220.18 | 11.17 | 244 | 102247 | 29901 | 70796052 |
Secondary immunodeficiency | 206.08 | 11.17 | 95 | 102396 | 2794 | 70823159 |
Paronychia | 200.77 | 11.17 | 126 | 102365 | 6948 | 70819005 |
Therapy partial responder | 194.48 | 11.17 | 154 | 102337 | 12320 | 70813633 |
Malignant neoplasm progression | 192.49 | 11.17 | 494 | 101997 | 121245 | 70704708 |
Vomiting | 182.01 | 11.17 | 1470 | 101021 | 591641 | 70234312 |
Portal hypertension | 172.70 | 11.17 | 111 | 102380 | 6381 | 70819572 |
Product dose omission issue | 170.84 | 11.17 | 51 | 102440 | 217417 | 70608536 |
Peripheral sensory neuropathy | 164.56 | 11.17 | 138 | 102353 | 11972 | 70813981 |
Nausea | 161.26 | 11.17 | 1908 | 100583 | 850180 | 69975773 |
Cardiotoxicity | 158.43 | 11.17 | 130 | 102361 | 10940 | 70815013 |
Enteritis | 157.62 | 11.17 | 138 | 102353 | 12693 | 70813260 |
Pulmonary embolism | 157.05 | 11.17 | 539 | 101952 | 155328 | 70670625 |
Metastases to lung | 155.47 | 11.17 | 153 | 102338 | 16331 | 70809622 |
Focal nodular hyperplasia | 150.76 | 11.17 | 51 | 102440 | 638 | 70825315 |
Pyrexia | 147.64 | 11.17 | 1430 | 101061 | 605522 | 70220431 |
Hyperammonaemia | 139.25 | 11.17 | 117 | 102374 | 10176 | 70815777 |
Peripheral swelling | 138.86 | 11.17 | 85 | 102406 | 236478 | 70589475 |
Drug abuse | 138.79 | 11.17 | 23 | 102468 | 147233 | 70678720 |
Drug clearance decreased | 131.58 | 11.17 | 71 | 102420 | 2942 | 70823011 |
Fall | 128.48 | 11.17 | 282 | 102209 | 443814 | 70382139 |
Rash pustular | 124.88 | 11.17 | 110 | 102381 | 10198 | 70815755 |
Swelling | 121.87 | 11.17 | 60 | 102431 | 188479 | 70637474 |
Chills | 121.58 | 11.17 | 472 | 102019 | 144314 | 70681639 |
Abdominal pain | 121.38 | 11.17 | 878 | 101613 | 341249 | 70484704 |
General physical health deterioration | 121.28 | 11.17 | 666 | 101825 | 235365 | 70590588 |
Systemic lupus erythematosus | 119.02 | 11.17 | 7 | 102484 | 101895 | 70724058 |
Adenocarcinoma of colon | 116.47 | 11.17 | 81 | 102410 | 5311 | 70820642 |
Leukoencephalopathy | 113.59 | 11.17 | 90 | 102401 | 7204 | 70818749 |
Hyperammonaemic encephalopathy | 110.91 | 11.17 | 73 | 102418 | 4370 | 70821583 |
Intestinal obstruction | 109.16 | 11.17 | 199 | 102292 | 38626 | 70787327 |
Posterior reversible encephalopathy syndrome | 108.35 | 11.17 | 154 | 102337 | 24248 | 70801705 |
Non-cirrhotic portal hypertension | 108.11 | 11.17 | 35 | 102456 | 378 | 70825575 |
Anaemia | 107.61 | 11.17 | 970 | 101521 | 402453 | 70423500 |
Carcinoembryonic antigen increased | 106.24 | 11.17 | 54 | 102437 | 1976 | 70823977 |
Mycobacterium chelonae infection | 104.06 | 11.17 | 56 | 102435 | 2308 | 70823645 |
Insomnia | 103.79 | 11.17 | 97 | 102394 | 217709 | 70608244 |
Gastrointestinal perforation | 103.60 | 11.17 | 77 | 102414 | 5604 | 70820349 |
Intentional overdose | 103.17 | 11.17 | 11 | 102480 | 98424 | 70727529 |
Hypomagnesaemia | 102.26 | 11.17 | 199 | 102292 | 40565 | 70785388 |
Asthma | 99.15 | 11.17 | 26 | 102465 | 120767 | 70705186 |
Venoocclusive liver disease | 98.63 | 11.17 | 98 | 102393 | 10580 | 70815373 |
Joint swelling | 98.56 | 11.17 | 133 | 102358 | 253078 | 70572875 |
Arthropathy | 98.11 | 11.17 | 47 | 102444 | 150010 | 70675943 |
Cholangitis | 97.57 | 11.17 | 101 | 102390 | 11448 | 70814505 |
Arthralgia | 96.75 | 11.17 | 387 | 102104 | 503003 | 70322950 |
Glossodynia | 95.05 | 11.17 | 8 | 102483 | 86479 | 70739474 |
Pneumatosis intestinalis | 92.45 | 11.17 | 73 | 102418 | 5814 | 70820139 |
Rhabdomyolysis | 92.38 | 11.17 | 14 | 102477 | 95746 | 70730207 |
Synovitis | 88.34 | 11.17 | 38 | 102453 | 129190 | 70696763 |
Device related infection | 88.00 | 11.17 | 163 | 102328 | 32022 | 70793931 |
Pain | 87.78 | 11.17 | 541 | 101950 | 628275 | 70197678 |
Interstitial lung disease | 86.80 | 11.17 | 340 | 102151 | 104345 | 70721608 |
Intestinal perforation | 86.06 | 11.17 | 111 | 102380 | 15933 | 70810020 |
Ascites | 84.74 | 11.17 | 252 | 102239 | 67295 | 70758658 |
Skin reaction | 84.61 | 11.17 | 103 | 102388 | 13946 | 70812007 |
Ileus | 82.23 | 11.17 | 135 | 102356 | 24102 | 70801851 |
Splenomegaly | 82.18 | 11.17 | 118 | 102373 | 18752 | 70807201 |
Decreased appetite | 80.74 | 11.17 | 732 | 101759 | 304048 | 70521905 |
Headache | 80.11 | 11.17 | 501 | 101990 | 579904 | 70246049 |
Epistaxis | 80.03 | 11.17 | 327 | 102164 | 102300 | 70723653 |
Administration site extravasation | 79.33 | 11.17 | 37 | 102454 | 1118 | 70824835 |
Weight increased | 78.42 | 11.17 | 144 | 102347 | 242187 | 70583766 |
Anxiety | 77.63 | 11.17 | 124 | 102367 | 220206 | 70605747 |
Mucosal toxicity | 77.38 | 11.17 | 30 | 102461 | 566 | 70825387 |
Tumour lysis syndrome | 76.58 | 11.17 | 122 | 102369 | 21238 | 70804715 |
Rheumatoid arthritis | 76.53 | 11.17 | 195 | 102296 | 291610 | 70534343 |
Bacterial infection | 76.01 | 11.17 | 137 | 102354 | 26355 | 70799598 |
Dizziness | 75.78 | 11.17 | 379 | 102112 | 463762 | 70362191 |
Febrile bone marrow aplasia | 75.63 | 11.17 | 90 | 102401 | 11901 | 70814052 |
Plasma cell myeloma | 74.64 | 11.17 | 9 | 102482 | 73192 | 70752761 |
Injury | 74.63 | 11.17 | 5 | 102486 | 65240 | 70760713 |
Hepatic enzyme increased | 73.49 | 11.17 | 71 | 102420 | 156919 | 70669034 |
Depression | 72.95 | 11.17 | 109 | 102382 | 198865 | 70627088 |
Myalgia | 71.78 | 11.17 | 82 | 102409 | 167810 | 70658143 |
Dehydration | 71.42 | 11.17 | 565 | 101926 | 225577 | 70600376 |
Contusion | 71 | 11.17 | 49 | 102442 | 127987 | 70697966 |
Human bocavirus infection | 69.90 | 11.17 | 28 | 102463 | 578 | 70825375 |
Drug ineffective | 68.64 | 11.17 | 952 | 101539 | 938800 | 69887153 |
Injection site pain | 67.94 | 11.17 | 43 | 102448 | 117576 | 70708377 |
Anastomotic leak | 67.70 | 11.17 | 32 | 102459 | 997 | 70824956 |
Pain in extremity | 67.61 | 11.17 | 245 | 102246 | 327837 | 70498116 |
Intentional product misuse | 67.50 | 11.17 | 16 | 102475 | 79579 | 70746374 |
Nicotinic acid deficiency | 67.33 | 11.17 | 20 | 102471 | 158 | 70825795 |
Pseudomonal sepsis | 66.89 | 11.17 | 59 | 102432 | 5478 | 70820475 |
Subileus | 65.77 | 11.17 | 57 | 102434 | 5170 | 70820783 |
Metastases to peritoneum | 65.73 | 11.17 | 50 | 102441 | 3769 | 70822184 |
Somnolence | 64.65 | 11.17 | 134 | 102357 | 215472 | 70610481 |
Tumour necrosis | 64.48 | 11.17 | 37 | 102454 | 1730 | 70824223 |
Myocardial infarction | 63.92 | 11.17 | 93 | 102398 | 171552 | 70654401 |
Pancytopenia | 63.11 | 11.17 | 404 | 102087 | 150703 | 70675250 |
Contraindicated product administered | 62.86 | 11.17 | 61 | 102430 | 134551 | 70691402 |
Maternal exposure during pregnancy | 62.82 | 11.17 | 45 | 102446 | 115300 | 70710653 |
Cardiac failure congestive | 62.55 | 11.17 | 62 | 102429 | 135395 | 70690558 |
Sinusitis | 61.71 | 11.17 | 93 | 102398 | 169102 | 70656851 |
Wheezing | 60.77 | 11.17 | 30 | 102461 | 94140 | 70731813 |
Lower respiratory tract infection | 60.51 | 11.17 | 44 | 102447 | 111869 | 70714084 |
Hospitalisation | 60.16 | 11.17 | 22 | 102469 | 82546 | 70743407 |
Neoplasm recurrence | 60.02 | 11.17 | 48 | 102443 | 3893 | 70822060 |
Parainfluenzae virus infection | 59.13 | 11.17 | 53 | 102438 | 5027 | 70820926 |
Peripheral sensorimotor neuropathy | 59.05 | 11.17 | 41 | 102450 | 2681 | 70823272 |
Helicobacter infection | 58.88 | 11.17 | 6 | 102485 | 55650 | 70770303 |
Paraesthesia | 58.87 | 11.17 | 386 | 102105 | 145151 | 70680802 |
Vena cava thrombosis | 58.24 | 11.17 | 40 | 102451 | 2570 | 70823383 |
Colon cancer metastatic | 57.81 | 11.17 | 37 | 102454 | 2111 | 70823842 |
Embolism | 57.70 | 11.17 | 82 | 102409 | 12906 | 70813047 |
Psoriasis | 56.83 | 11.17 | 36 | 102455 | 98397 | 70727556 |
Hyperbilirubinaemia | 56.38 | 11.17 | 110 | 102381 | 22458 | 70803495 |
Mobility decreased | 56.33 | 11.17 | 40 | 102451 | 102959 | 70722994 |
Loss of employment | 56.10 | 11.17 | 37 | 102454 | 2222 | 70823731 |
Chronic obstructive pulmonary disease | 56.04 | 11.17 | 21 | 102470 | 77620 | 70748333 |
Anti-cyclic citrullinated peptide antibody positive | 55.91 | 11.17 | 16 | 102475 | 70169 | 70755784 |
Diffuse alveolar damage | 55.62 | 11.17 | 43 | 102448 | 3320 | 70822633 |
Discomfort | 55.02 | 11.17 | 43 | 102448 | 105393 | 70720560 |
Hypertension | 54.69 | 11.17 | 661 | 101830 | 295372 | 70530581 |
Abdominal discomfort | 54.29 | 11.17 | 146 | 102345 | 214512 | 70611441 |
Small intestinal obstruction | 54.25 | 11.17 | 114 | 102377 | 24541 | 70801412 |
Sepsis | 53.75 | 11.17 | 565 | 101926 | 243980 | 70581973 |
Electrocardiogram QT prolonged | 53.30 | 11.17 | 27 | 102464 | 83490 | 70742463 |
Gene mutation | 53.23 | 11.17 | 36 | 102455 | 2255 | 70823698 |
Colorectal cancer | 52.48 | 11.17 | 63 | 102428 | 8407 | 70817546 |
Blister | 52.45 | 11.17 | 41 | 102450 | 100485 | 70725468 |
Hiccups | 52.31 | 11.17 | 65 | 102426 | 8987 | 70816966 |
Pelvic abscess | 52.08 | 11.17 | 33 | 102458 | 1850 | 70824103 |
Memory impairment | 51.96 | 11.17 | 35 | 102456 | 92606 | 70733347 |
Suicidal ideation | 51.63 | 11.17 | 18 | 102473 | 69578 | 70756375 |
Colitis | 51.05 | 11.17 | 205 | 102286 | 63609 | 70762344 |
Wound | 50.59 | 11.17 | 41 | 102450 | 98691 | 70727262 |
Feeling abnormal | 50.20 | 11.17 | 80 | 102411 | 142239 | 70683714 |
Abscess bacterial | 50.13 | 11.17 | 24 | 102467 | 770 | 70825183 |
Neutrophil count decreased | 49.90 | 11.17 | 246 | 102245 | 83310 | 70742643 |
Crystal nephropathy | 49.73 | 11.17 | 28 | 102463 | 1262 | 70824691 |
Metastases to lymph nodes | 49.68 | 11.17 | 64 | 102427 | 9174 | 70816779 |
Transdifferentiation of neoplasm | 49.63 | 11.17 | 14 | 102477 | 90 | 70825863 |
Metastases to meninges | 49.49 | 11.17 | 39 | 102452 | 3097 | 70822856 |
Dysarthria | 48.91 | 11.17 | 199 | 102292 | 62114 | 70763839 |
Asthenia | 48.75 | 11.17 | 930 | 101561 | 456736 | 70369217 |
Pneumonia | 48.53 | 11.17 | 590 | 101901 | 595642 | 70230311 |
Drug hypersensitivity | 47.67 | 11.17 | 206 | 102285 | 262253 | 70563700 |
Confusional state | 47.62 | 11.17 | 230 | 102261 | 284168 | 70541785 |
Blood cholesterol increased | 47.43 | 11.17 | 17 | 102474 | 64587 | 70761366 |
Wrong technique in product usage process | 47.26 | 11.17 | 20 | 102471 | 68678 | 70757275 |
Lymphoid tissue hypoplasia | 46.94 | 11.17 | 21 | 102470 | 575 | 70825378 |
Bradycardia | 46.89 | 11.17 | 67 | 102424 | 124548 | 70701405 |
Drug interaction | 46.66 | 11.17 | 341 | 102150 | 381100 | 70444853 |
Hypokalaemia | 46.56 | 11.17 | 337 | 102154 | 130851 | 70695102 |
Steatohepatitis | 46.43 | 11.17 | 23 | 102468 | 796 | 70825157 |
Recall phenomenon | 46.37 | 11.17 | 25 | 102466 | 1034 | 70824919 |
Overdose | 46.36 | 11.17 | 111 | 102380 | 169634 | 70656319 |
Fluid retention | 45.99 | 11.17 | 17 | 102474 | 63368 | 70762585 |
Thymus hypoplasia | 45.54 | 11.17 | 21 | 102470 | 618 | 70825335 |
Portal vein thrombosis | 45.48 | 11.17 | 47 | 102444 | 5315 | 70820638 |
Type II hypersensitivity | 45.27 | 11.17 | 11 | 102480 | 35 | 70825918 |
Coronary artery disease | 45.22 | 11.17 | 17 | 102474 | 62719 | 70763234 |
Cholinergic syndrome | 44.72 | 11.17 | 23 | 102468 | 863 | 70825090 |
Sedation | 44.68 | 11.17 | 7 | 102484 | 46724 | 70779229 |
Enterobacter infection | 44.59 | 11.17 | 41 | 102450 | 4019 | 70821934 |
Deep vein thrombosis | 44.58 | 11.17 | 294 | 102197 | 110748 | 70715205 |
Peritonitis | 44.26 | 11.17 | 109 | 102382 | 26050 | 70799903 |
Hand deformity | 44.20 | 11.17 | 36 | 102455 | 86446 | 70739507 |
Duodenal ulcer perforation | 43.88 | 11.17 | 10 | 102481 | 51102 | 70774851 |
Human herpesvirus 6 infection | 43.78 | 11.17 | 44 | 102447 | 4815 | 70821138 |
Rectal tenesmus | 43.01 | 11.17 | 26 | 102465 | 1340 | 70824613 |
ECG signs of myocardial ischaemia | 42.71 | 11.17 | 17 | 102474 | 345 | 70825608 |
Hallucination | 42.51 | 11.17 | 29 | 102462 | 76231 | 70749722 |
Trichomegaly | 42.43 | 11.17 | 12 | 102479 | 78 | 70825875 |
Anastomotic complication | 42.39 | 11.17 | 18 | 102473 | 433 | 70825520 |
Pericarditis | 42.38 | 11.17 | 36 | 102455 | 84669 | 70741284 |
Drug dependence | 42.27 | 11.17 | 3 | 102488 | 37318 | 70788635 |
Haemolytic anaemia | 42.13 | 11.17 | 82 | 102409 | 16712 | 70809241 |
Venous thrombosis | 42.09 | 11.17 | 50 | 102441 | 6599 | 70819354 |
Superior vena cava syndrome | 41.79 | 11.17 | 24 | 102467 | 1124 | 70824829 |
Influenza | 40.96 | 11.17 | 63 | 102428 | 113637 | 70712316 |
Productive cough | 40.80 | 11.17 | 32 | 102459 | 78305 | 70747648 |
Stress | 40.42 | 11.17 | 24 | 102467 | 67942 | 70758011 |
Proteus infection | 40.40 | 11.17 | 27 | 102464 | 1658 | 70824295 |
Treatment noncompliance | 40.21 | 11.17 | 9 | 102482 | 46565 | 70779388 |
Ocular toxicity | 40.06 | 11.17 | 21 | 102470 | 820 | 70825133 |
Exposure during pregnancy | 39.51 | 11.17 | 41 | 102450 | 87676 | 70738277 |
Jugular vein thrombosis | 39.27 | 11.17 | 38 | 102453 | 3972 | 70821981 |
K-ras gene mutation | 39.18 | 11.17 | 10 | 102481 | 41 | 70825912 |
Intentional product use issue | 39.18 | 11.17 | 71 | 102420 | 120071 | 70705882 |
Blood glucose increased | 39.11 | 11.17 | 55 | 102436 | 102927 | 70723026 |
Clostridium difficile colitis | 39.07 | 11.17 | 111 | 102380 | 28885 | 70797068 |
Gastrooesophageal reflux disease | 38.12 | 11.17 | 45 | 102446 | 90794 | 70735159 |
Norovirus test positive | 37.51 | 11.17 | 17 | 102474 | 480 | 70825473 |
Cystitis bacterial | 37.35 | 11.17 | 17 | 102474 | 485 | 70825468 |
Carbohydrate antigen 19-9 increased | 37.07 | 11.17 | 16 | 102475 | 401 | 70825552 |
Gait disturbance | 36.92 | 11.17 | 140 | 102351 | 184966 | 70640987 |
Pancreatic carcinoma metastatic | 36.87 | 11.17 | 36 | 102455 | 3804 | 70822149 |
Product prescribing error | 36.87 | 11.17 | 6 | 102485 | 38946 | 70787007 |
Septic shock | 36.79 | 11.17 | 283 | 102208 | 111975 | 70713978 |
Off label use | 36.77 | 11.17 | 1365 | 101126 | 741695 | 70084258 |
Neutropenic colitis | 36.65 | 11.17 | 41 | 102450 | 5073 | 70820880 |
Acute coronary syndrome | 36.48 | 11.17 | 86 | 102405 | 19993 | 70805960 |
Rectal cancer metastatic | 36.44 | 11.17 | 17 | 102474 | 514 | 70825439 |
Balance disorder | 36.40 | 11.17 | 46 | 102445 | 90082 | 70735871 |
Unevaluable event | 36.06 | 11.17 | 15 | 102476 | 52048 | 70773905 |
Adverse drug reaction | 35.94 | 11.17 | 16 | 102475 | 53328 | 70772625 |
Immune thrombocytopenia | 35.36 | 11.17 | 75 | 102416 | 16249 | 70809704 |
Febrile infection | 35.32 | 11.17 | 32 | 102459 | 3077 | 70822876 |
International normalised ratio increased | 34.95 | 11.17 | 39 | 102452 | 80687 | 70745266 |
Large intestinal obstruction | 34.81 | 11.17 | 31 | 102460 | 2915 | 70823038 |
Rectal perforation | 34.67 | 11.17 | 19 | 102472 | 812 | 70825141 |
Oesophageal atresia | 34.60 | 11.17 | 10 | 102481 | 71 | 70825882 |
Emotional distress | 34.59 | 11.17 | 6 | 102485 | 37182 | 70788771 |
Intentional self-injury | 34.57 | 11.17 | 3 | 102488 | 31647 | 70794306 |
Cardiac arrest | 34.46 | 11.17 | 117 | 102374 | 159717 | 70666236 |
Proctalgia | 34.43 | 11.17 | 51 | 102440 | 8332 | 70817621 |
Subclavian vein thrombosis | 34.22 | 11.17 | 28 | 102463 | 2346 | 70823607 |
Pelvic fluid collection | 33.98 | 11.17 | 18 | 102473 | 718 | 70825235 |
Arthritis | 33.68 | 11.17 | 56 | 102435 | 97924 | 70728029 |
Pulmonary arterial hypertension | 33.59 | 11.17 | 4 | 102487 | 32851 | 70793102 |
Respiratory arrest | 33.57 | 11.17 | 18 | 102473 | 53915 | 70772038 |
Knee arthroplasty | 33.11 | 11.17 | 5 | 102486 | 34296 | 70791657 |
Varices oesophageal | 33.08 | 11.17 | 40 | 102451 | 5377 | 70820576 |
Factor VII deficiency | 32.79 | 11.17 | 8 | 102483 | 26 | 70825927 |
Ileal perforation | 32.75 | 11.17 | 19 | 102472 | 907 | 70825046 |
Medication error | 32.59 | 11.17 | 21 | 102470 | 56891 | 70769062 |
Klebsiella infection | 32.51 | 11.17 | 67 | 102424 | 14225 | 70811728 |
Hypoglycaemia | 32.37 | 11.17 | 54 | 102437 | 94310 | 70731643 |
Hepatic lesion | 32.30 | 11.17 | 42 | 102449 | 6075 | 70819878 |
Small intestinal perforation | 32.30 | 11.17 | 30 | 102461 | 2979 | 70822974 |
Migraine | 32.27 | 11.17 | 34 | 102457 | 72204 | 70753749 |
Gastrointestinal anastomotic leak | 32.11 | 11.17 | 15 | 102476 | 455 | 70825498 |
Gait inability | 32.02 | 11.17 | 14 | 102477 | 47161 | 70778792 |
Injection site erythema | 31.82 | 11.17 | 35 | 102456 | 72889 | 70753064 |
Nodular regenerative hyperplasia | 31.68 | 11.17 | 21 | 102470 | 1272 | 70824681 |
Intravascular haemolysis | 31.53 | 11.17 | 17 | 102474 | 703 | 70825250 |
T-cell lymphoma refractory | 31.50 | 11.17 | 9 | 102482 | 61 | 70825892 |
Anal haemorrhage | 31.42 | 11.17 | 33 | 102458 | 3803 | 70822150 |
Adenocarcinoma | 30.95 | 11.17 | 32 | 102459 | 3621 | 70822332 |
Enterocutaneous fistula | 30.93 | 11.17 | 23 | 102468 | 1675 | 70824278 |
Portal shunt | 30.88 | 11.17 | 9 | 102482 | 66 | 70825887 |
Electrocardiogram ST segment elevation | 30.86 | 11.17 | 46 | 102445 | 7558 | 70818395 |
Liver abscess | 30.44 | 11.17 | 39 | 102452 | 5560 | 70820393 |
Hypersensitivity vasculitis | 30.20 | 11.17 | 43 | 102448 | 6779 | 70819174 |
Anastomotic fistula | 30.16 | 11.17 | 10 | 102481 | 117 | 70825836 |
Enterovesical fistula | 30.00 | 11.17 | 19 | 102472 | 1064 | 70824889 |
Nasopharyngitis | 29.93 | 11.17 | 193 | 102298 | 222013 | 70603940 |
Rectal adenocarcinoma | 29.90 | 11.17 | 21 | 102470 | 1399 | 70824554 |
Colon cancer recurrent | 29.79 | 11.17 | 10 | 102481 | 122 | 70825831 |
Cystitis radiation | 29.64 | 11.17 | 10 | 102481 | 124 | 70825829 |
Encephalopathy | 29.61 | 11.17 | 171 | 102320 | 61490 | 70764463 |
Urticaria | 29.57 | 11.17 | 128 | 102363 | 162921 | 70663032 |
Blood creatine phosphokinase increased | 29.48 | 11.17 | 27 | 102464 | 61236 | 70764717 |
Dyspnoea | 29.43 | 11.17 | 868 | 101623 | 769192 | 70056761 |
Acute abdomen | 29.43 | 11.17 | 28 | 102463 | 2866 | 70823087 |
Leukoerythroblastosis | 29.42 | 11.17 | 12 | 102479 | 260 | 70825693 |
Necrotising fasciitis | 29.27 | 11.17 | 38 | 102453 | 5488 | 70820465 |
Koebner phenomenon | 28.69 | 11.17 | 8 | 102483 | 49 | 70825904 |
Hypoalbuminaemia | 28.54 | 11.17 | 76 | 102415 | 19046 | 70806907 |
Liver function test abnormal | 28.20 | 11.17 | 28 | 102463 | 61118 | 70764835 |
Nasal septum perforation | 28.18 | 11.17 | 16 | 102475 | 733 | 70825220 |
Aortic thrombosis | 28.09 | 11.17 | 21 | 102470 | 1542 | 70824411 |
Obesity | 28.02 | 11.17 | 3 | 102488 | 26768 | 70799185 |
Agitation | 27.99 | 11.17 | 58 | 102433 | 93317 | 70732636 |
Condition aggravated | 27.98 | 11.17 | 442 | 102049 | 427193 | 70398760 |
Aggression | 27.57 | 11.17 | 18 | 102473 | 48428 | 70777525 |
Pharyngeal dyskinesia | 27.53 | 11.17 | 8 | 102483 | 58 | 70825895 |
Erythema | 27.52 | 11.17 | 423 | 102068 | 199140 | 70626813 |
Treatment failure | 27.47 | 11.17 | 111 | 102380 | 144031 | 70681922 |
Neuromyotonia | 27.41 | 11.17 | 9 | 102482 | 102 | 70825851 |
Cardio-respiratory arrest | 27.34 | 11.17 | 66 | 102425 | 100611 | 70725342 |
Viraemia | 27.05 | 11.17 | 25 | 102466 | 2467 | 70823486 |
Type 2 diabetes mellitus | 27.02 | 11.17 | 15 | 102476 | 44065 | 70781888 |
Oesophageal candidiasis | 27.00 | 11.17 | 46 | 102445 | 8461 | 70817492 |
Loss of personal independence in daily activities | 26.95 | 11.17 | 51 | 102440 | 84859 | 70741094 |
Acute kidney injury | 26.92 | 11.17 | 886 | 101605 | 473738 | 70352215 |
Large intestine perforation | 26.72 | 11.17 | 59 | 102432 | 13136 | 70812817 |
Visual impairment | 26.54 | 11.17 | 47 | 102444 | 80203 | 70745750 |
Encapsulating peritoneal sclerosis | 26.53 | 11.17 | 16 | 102475 | 821 | 70825132 |
Stoma site haemorrhage | 26.42 | 11.17 | 21 | 102470 | 1688 | 70824265 |
Injection site haemorrhage | 26.36 | 11.17 | 3 | 102488 | 25524 | 70800429 |
Organising pneumonia | 26.35 | 11.17 | 50 | 102441 | 10000 | 70815953 |
Metastasis | 26.28 | 11.17 | 38 | 102453 | 6076 | 70819877 |
Prothrombin level decreased | 26.16 | 11.17 | 20 | 102471 | 1519 | 70824434 |
Rectal cancer recurrent | 26.13 | 11.17 | 7 | 102484 | 36 | 70825917 |
Conjunctivitis | 26.09 | 11.17 | 82 | 102409 | 22554 | 70803399 |
Impaired healing | 26.03 | 11.17 | 42 | 102449 | 74332 | 70751621 |
Cytopenia | 26.01 | 11.17 | 69 | 102422 | 17254 | 70808699 |
Cytomegalovirus chorioretinitis | 25.86 | 11.17 | 35 | 102456 | 5263 | 70820690 |
Portal venous gas | 25.81 | 11.17 | 12 | 102479 | 360 | 70825593 |
Laryngospasm | 25.75 | 11.17 | 29 | 102462 | 3614 | 70822339 |
Induration | 25.71 | 11.17 | 21 | 102470 | 1755 | 70824198 |
Influenza like illness | 25.70 | 11.17 | 34 | 102457 | 65297 | 70760656 |
Cachexia | 25.64 | 11.17 | 49 | 102442 | 9851 | 70816102 |
Cerebral haemorrhage | 25.61 | 11.17 | 24 | 102467 | 53840 | 70772113 |
Nephrotic syndrome | 25.54 | 11.17 | 51 | 102440 | 10589 | 70815364 |
Short-bowel syndrome | 25.32 | 11.17 | 13 | 102478 | 486 | 70825467 |
Perihepatic abscess | 25.24 | 11.17 | 9 | 102482 | 133 | 70825820 |
Injection site reaction | 25.16 | 11.17 | 21 | 102470 | 49831 | 70776122 |
Venous pressure jugular decreased | 25.00 | 11.17 | 8 | 102483 | 83 | 70825870 |
Irritability | 24.92 | 11.17 | 12 | 102479 | 38213 | 70787740 |
Loss of consciousness | 24.85 | 11.17 | 128 | 102363 | 155588 | 70670365 |
Chronic kidney disease | 24.82 | 11.17 | 31 | 102460 | 61026 | 70764927 |
Thrombocytopenic purpura | 24.78 | 11.17 | 23 | 102468 | 2281 | 70823672 |
Adverse event | 24.76 | 11.17 | 21 | 102470 | 49440 | 70776513 |
Venous thrombosis limb | 24.74 | 11.17 | 30 | 102461 | 4045 | 70821908 |
Gastrointestinal stoma complication | 24.65 | 11.17 | 23 | 102468 | 2297 | 70823656 |
Haemolytic uraemic syndrome | 24.42 | 11.17 | 30 | 102461 | 4100 | 70821853 |
Performance status decreased | 24.35 | 11.17 | 35 | 102456 | 5566 | 70820387 |
Mixed adenoneuroendocrine carcinoma | 24.25 | 11.17 | 6 | 102485 | 21 | 70825932 |
Oesophagobronchial fistula | 24.13 | 11.17 | 10 | 102481 | 226 | 70825727 |
Device related thrombosis | 24.07 | 11.17 | 23 | 102468 | 2367 | 70823586 |
Evans syndrome | 24.05 | 11.17 | 12 | 102479 | 422 | 70825531 |
Atypical haemolytic uraemic syndrome | 23.96 | 11.17 | 15 | 102476 | 823 | 70825130 |
Teratogenicity | 23.84 | 11.17 | 10 | 102481 | 233 | 70825720 |
Interventricular septum rupture | 23.83 | 11.17 | 6 | 102485 | 23 | 70825930 |
Muscle spasms | 23.81 | 11.17 | 128 | 102363 | 153918 | 70672035 |
Gastrointestinal necrosis | 23.76 | 11.17 | 33 | 102458 | 5085 | 70820868 |
Joint ankylosis | 23.66 | 11.17 | 19 | 102472 | 1550 | 70824403 |
Nipple swelling | 23.65 | 11.17 | 8 | 102483 | 100 | 70825853 |
Hepatocellular injury | 23.57 | 11.17 | 130 | 102361 | 45961 | 70779992 |
Pulmonary congestion | 23.53 | 11.17 | 4 | 102487 | 25150 | 70800803 |
Toxic erythema of chemotherapy | 23.49 | 11.17 | 10 | 102481 | 242 | 70825711 |
Perineal disorder | 23.43 | 11.17 | 6 | 102485 | 25 | 70825928 |
Meningitis streptococcal | 23.35 | 11.17 | 9 | 102482 | 167 | 70825786 |
Musculoskeletal stiffness | 23.27 | 11.17 | 122 | 102369 | 147638 | 70678315 |
Fibromyalgia | 23.15 | 11.17 | 21 | 102470 | 47853 | 70778100 |
Full blood count abnormal | 23.08 | 11.17 | 10 | 102481 | 33868 | 70792085 |
Tumour fistulisation | 23.06 | 11.17 | 6 | 102485 | 27 | 70825926 |
Rectal cancer | 23.04 | 11.17 | 26 | 102465 | 3248 | 70822705 |
Anaemia of malignant disease | 23.03 | 11.17 | 14 | 102477 | 729 | 70825224 |
Eczema impetiginous | 22.88 | 11.17 | 6 | 102485 | 28 | 70825925 |
Astringent therapy | 22.88 | 11.17 | 6 | 102485 | 28 | 70825925 |
Psychotic disorder | 22.86 | 11.17 | 13 | 102478 | 37688 | 70788265 |
Jaundice | 22.79 | 11.17 | 137 | 102354 | 49971 | 70775982 |
Oesophageal fistula | 22.55 | 11.17 | 11 | 102480 | 368 | 70825585 |
Poisoning | 22.53 | 11.17 | 3 | 102488 | 22619 | 70803334 |
Illness | 22.27 | 11.17 | 9 | 102482 | 31782 | 70794171 |
Ischiorectal hernia | 22.23 | 11.17 | 5 | 102486 | 10 | 70825943 |
Hepatic failure | 22.17 | 11.17 | 151 | 102340 | 57474 | 70768479 |
Incorrect dose administered | 22.13 | 11.17 | 39 | 102452 | 66680 | 70759273 |
Hypoacusis | 22.12 | 11.17 | 6 | 102485 | 27263 | 70798690 |
Therapeutic product effect decreased | 22.02 | 11.17 | 119 | 102372 | 142899 | 70683054 |
Prescribed overdose | 22.01 | 11.17 | 6 | 102485 | 27175 | 70798778 |
Hepatic steatosis | 21.95 | 11.17 | 102 | 102389 | 33711 | 70792242 |
Nightmare | 21.92 | 11.17 | 3 | 102488 | 22153 | 70803800 |
Injection site bruising | 21.82 | 11.17 | 14 | 102477 | 38018 | 70787935 |
Swelling face | 21.80 | 11.17 | 36 | 102455 | 63128 | 70762825 |
Vasospasm | 21.78 | 11.17 | 15 | 102476 | 968 | 70824985 |
Pregnancy | 21.77 | 11.17 | 4 | 102487 | 23777 | 70802176 |
Sleep apnoea syndrome | 21.74 | 11.17 | 10 | 102481 | 32703 | 70793250 |
Oesophagitis | 21.61 | 11.17 | 77 | 102414 | 22575 | 70803378 |
Joint stiffness | 21.51 | 11.17 | 12 | 102479 | 35164 | 70790789 |
Haematopoietic stem cell mobilisation | 21.49 | 11.17 | 9 | 102482 | 209 | 70825744 |
Periportal sinus dilatation | 21.48 | 11.17 | 6 | 102485 | 37 | 70825916 |
Aplasia | 21.44 | 11.17 | 38 | 102453 | 7213 | 70818740 |
Depilation | 21.32 | 11.17 | 5 | 102486 | 13 | 70825940 |
Allodynia | 21.29 | 11.17 | 17 | 102474 | 1376 | 70824577 |
Clostridial infection | 21.29 | 11.17 | 32 | 102459 | 5297 | 70820656 |
Proctitis | 21.28 | 11.17 | 26 | 102465 | 3532 | 70822421 |
Lymphopenia | 21.17 | 11.17 | 87 | 102404 | 27272 | 70798681 |
Skin discolouration | 21.06 | 11.17 | 14 | 102477 | 37311 | 70788642 |
Stress cardiomyopathy | 21.00 | 11.17 | 45 | 102446 | 9817 | 70816136 |
Product use issue | 20.94 | 11.17 | 163 | 102328 | 179774 | 70646179 |
Biliary tract infection | 20.88 | 11.17 | 16 | 102475 | 1219 | 70824734 |
Laboratory test interference | 20.81 | 11.17 | 15 | 102476 | 1041 | 70824912 |
Oesophageal haemorrhage | 20.73 | 11.17 | 18 | 102473 | 1637 | 70824316 |
Obstructive airways disorder | 20.71 | 11.17 | 6 | 102485 | 26107 | 70799846 |
Hypocalcaemia | 20.63 | 11.17 | 123 | 102368 | 44736 | 70781217 |
Injection site pruritus | 20.44 | 11.17 | 16 | 102475 | 39194 | 70786759 |
Mouth ulceration | 20.40 | 11.17 | 101 | 102390 | 34248 | 70791705 |
Visceral venous thrombosis | 20.32 | 11.17 | 5 | 102486 | 17 | 70825936 |
Catabolic state | 20.31 | 11.17 | 7 | 102484 | 93 | 70825860 |
Depressed mood | 20.28 | 11.17 | 20 | 102471 | 43800 | 70782153 |
Bronchitis | 20.07 | 11.17 | 94 | 102397 | 117149 | 70708804 |
Portal vein dilatation | 20.02 | 11.17 | 6 | 102485 | 49 | 70825904 |
Cholestasis | 19.96 | 11.17 | 128 | 102363 | 47744 | 70778209 |
Mucocutaneous rash | 19.92 | 11.17 | 6 | 102485 | 50 | 70825903 |
Chemotherapy cardiotoxicity attenuation | 19.89 | 11.17 | 5 | 102486 | 19 | 70825934 |
Bacteriuria | 19.89 | 11.17 | 15 | 102476 | 1116 | 70824837 |
Hepatitis B surface antigen positive | 19.76 | 11.17 | 8 | 102483 | 170 | 70825783 |
Breast cancer | 19.73 | 11.17 | 12 | 102479 | 33537 | 70792416 |
Multiple sclerosis | 19.70 | 11.17 | 6 | 102485 | 25279 | 70800674 |
Myeloid leukaemia | 19.68 | 11.17 | 12 | 102479 | 628 | 70825325 |
Panic attack | 19.65 | 11.17 | 4 | 102487 | 22115 | 70803838 |
Adrenal insufficiency | 19.59 | 11.17 | 6 | 102485 | 25189 | 70800764 |
Oedema | 19.58 | 11.17 | 80 | 102411 | 103501 | 70722452 |
Tremor | 19.53 | 11.17 | 138 | 102353 | 155486 | 70670467 |
Cardiac disorder | 19.46 | 11.17 | 35 | 102456 | 59380 | 70766573 |
Heart rate increased | 19.44 | 11.17 | 83 | 102408 | 106065 | 70719888 |
Hypertrichosis | 19.39 | 11.17 | 15 | 102476 | 1159 | 70824794 |
Abortion spontaneous | 19.38 | 11.17 | 7 | 102484 | 26472 | 70799481 |
Skin injury | 19.31 | 11.17 | 22 | 102469 | 2776 | 70823177 |
Hepatectomy | 19.25 | 11.17 | 8 | 102483 | 182 | 70825771 |
Hyperthyroidism | 19.23 | 11.17 | 3 | 102488 | 20088 | 70805865 |
Pneumonitis | 19.21 | 11.17 | 140 | 102351 | 54457 | 70771496 |
Cerebrovascular accident | 19.11 | 11.17 | 125 | 102366 | 143345 | 70682608 |
Hypotension | 19.04 | 11.17 | 442 | 102049 | 403939 | 70422014 |
Anal erythema | 18.97 | 11.17 | 8 | 102483 | 189 | 70825764 |
Radiation interaction | 18.95 | 11.17 | 6 | 102485 | 60 | 70825893 |
Pneumoperitoneum | 18.87 | 11.17 | 22 | 102469 | 2847 | 70823106 |
Anal fissure | 18.86 | 11.17 | 33 | 102458 | 6200 | 70819753 |
Sleep disorder | 18.82 | 11.17 | 46 | 102445 | 69826 | 70756127 |
Endometrial dysplasia | 18.78 | 11.17 | 5 | 102486 | 25 | 70825928 |
Aortic intramural haematoma | 18.78 | 11.17 | 7 | 102484 | 118 | 70825835 |
Psoriatic arthropathy | 18.77 | 11.17 | 41 | 102450 | 64730 | 70761223 |
Restlessness | 18.62 | 11.17 | 20 | 102471 | 42108 | 70783845 |
Prostatic calcification | 18.60 | 11.17 | 6 | 102485 | 64 | 70825889 |
Injection site swelling | 18.51 | 11.17 | 21 | 102470 | 43136 | 70782817 |
Perioral dermatitis | 18.48 | 11.17 | 9 | 102482 | 300 | 70825653 |
Pulmonary artery thrombosis | 18.42 | 11.17 | 15 | 102476 | 1248 | 70824705 |
Cranial nerve disorder | 18.32 | 11.17 | 14 | 102477 | 1062 | 70824891 |
Rhinovirus infection | 18.27 | 11.17 | 34 | 102457 | 6699 | 70819254 |
Road traffic accident | 18.27 | 11.17 | 14 | 102477 | 34668 | 70791285 |
Joint injury | 18.27 | 11.17 | 8 | 102483 | 26924 | 70799029 |
Thrombotic microangiopathy | 18.18 | 11.17 | 62 | 102429 | 17786 | 70808167 |
Product administration error | 18.16 | 11.17 | 10 | 102481 | 29513 | 70796440 |
Balanoposthitis | 18.15 | 11.17 | 13 | 102478 | 893 | 70825060 |
Faeces discoloured | 18.12 | 11.17 | 8 | 102483 | 26801 | 70799152 |
Hypertransaminasaemia | 18.12 | 11.17 | 40 | 102451 | 8903 | 70817050 |
Viral hepatitis carrier | 18.02 | 11.17 | 5 | 102486 | 30 | 70825923 |
Bladder hypertrophy | 17.90 | 11.17 | 11 | 102480 | 584 | 70825369 |
Product quality issue | 17.88 | 11.17 | 11 | 102480 | 30550 | 70795403 |
Head injury | 17.71 | 11.17 | 14 | 102477 | 34127 | 70791826 |
Adenocarcinoma pancreas | 17.68 | 11.17 | 18 | 102473 | 2000 | 70823953 |
Cerebral vasoconstriction | 17.65 | 11.17 | 15 | 102476 | 1325 | 70824628 |
Duodenal perforation | 17.52 | 11.17 | 18 | 102473 | 2022 | 70823931 |
Coronavirus infection | 17.51 | 11.17 | 32 | 102459 | 6220 | 70819733 |
Onycholysis | 17.49 | 11.17 | 17 | 102474 | 1786 | 70824167 |
Multiple-drug resistance | 17.35 | 11.17 | 35 | 102456 | 7320 | 70818633 |
Cough | 17.23 | 11.17 | 349 | 102142 | 325028 | 70500925 |
Joint range of motion decreased | 17.23 | 11.17 | 8 | 102483 | 26018 | 70799935 |
Perforation bile duct | 17.12 | 11.17 | 5 | 102486 | 37 | 70825916 |
Abnormal behaviour | 17.05 | 11.17 | 15 | 102476 | 34694 | 70791259 |
Tumour perforation | 17.04 | 11.17 | 9 | 102482 | 357 | 70825596 |
Pancreatic carcinoma recurrent | 16.90 | 11.17 | 7 | 102484 | 158 | 70825795 |
Anal erosion | 16.78 | 11.17 | 5 | 102486 | 40 | 70825913 |
Pruritus | 16.74 | 11.17 | 376 | 102115 | 345184 | 70480769 |
Neurosarcoidosis | 16.72 | 11.17 | 9 | 102482 | 371 | 70825582 |
Rectal abscess | 16.67 | 11.17 | 16 | 102475 | 1655 | 70824298 |
Second primary malignancy | 16.65 | 11.17 | 49 | 102442 | 13002 | 70812951 |
Enterocolitis | 16.62 | 11.17 | 49 | 102442 | 13017 | 70812936 |
Blood pressure decreased | 16.48 | 11.17 | 72 | 102419 | 91443 | 70734510 |
Catheter site extravasation | 16.41 | 11.17 | 9 | 102482 | 385 | 70825568 |
Full blood count decreased | 16.39 | 11.17 | 7 | 102484 | 23911 | 70802042 |
Peritoneal neoplasm | 16.27 | 11.17 | 6 | 102485 | 98 | 70825855 |
Dysstasia | 16.27 | 11.17 | 8 | 102483 | 25171 | 70800782 |
Perineal abscess | 16.27 | 11.17 | 10 | 102481 | 531 | 70825422 |
Pulmonary toxicity | 16.20 | 11.17 | 43 | 102448 | 10755 | 70815198 |
Bladder tamponade | 16.17 | 11.17 | 10 | 102481 | 537 | 70825416 |
Obstruction gastric | 16.15 | 11.17 | 15 | 102476 | 1489 | 70824464 |
Therapy non-responder | 16.09 | 11.17 | 57 | 102434 | 76858 | 70749095 |
Brief psychotic disorder with marked stressors | 16.07 | 11.17 | 8 | 102483 | 280 | 70825673 |
Dermatitis | 16.02 | 11.17 | 63 | 102428 | 19354 | 70806599 |
Vascular access complication | 15.96 | 11.17 | 16 | 102475 | 1745 | 70824208 |
Delusion | 15.96 | 11.17 | 4 | 102487 | 19161 | 70806792 |
Temperature difference of extremities | 15.95 | 11.17 | 4 | 102487 | 15 | 70825938 |
Intestinal metastasis | 15.94 | 11.17 | 8 | 102483 | 285 | 70825668 |
Pulmonary infarction | 15.78 | 11.17 | 22 | 102469 | 3401 | 70822552 |
Cognitive disorder | 15.74 | 11.17 | 41 | 102450 | 60915 | 70765038 |
Volvulus of small bowel | 15.64 | 11.17 | 6 | 102485 | 110 | 70825843 |
Red cell fragmentation syndrome | 15.61 | 11.17 | 5 | 102486 | 52 | 70825901 |
Inferior vena cava stenosis | 15.61 | 11.17 | 5 | 102486 | 52 | 70825901 |
Bladder cancer | 15.57 | 11.17 | 3 | 102488 | 17239 | 70808714 |
Portal vein embolisation | 15.56 | 11.17 | 4 | 102487 | 17 | 70825936 |
Cataract | 15.49 | 11.17 | 36 | 102455 | 55609 | 70770344 |
Mania | 15.48 | 11.17 | 3 | 102488 | 17171 | 70808782 |
Encephalitis | 15.46 | 11.17 | 49 | 102442 | 13536 | 70812417 |
Systemic scleroderma | 15.45 | 11.17 | 13 | 102478 | 1132 | 70824821 |
Haematoma | 15.43 | 11.17 | 29 | 102462 | 48389 | 70777564 |
Dysaesthesia pharynx | 15.37 | 11.17 | 7 | 102484 | 200 | 70825753 |
Subacute cutaneous lupus erythematosus | 15.34 | 11.17 | 21 | 102470 | 3192 | 70822761 |
Underdose | 15.30 | 11.17 | 12 | 102479 | 29371 | 70796582 |
Intestinal strangulation | 15.28 | 11.17 | 5 | 102486 | 56 | 70825897 |
Soft tissue necrosis | 15.25 | 11.17 | 11 | 102480 | 764 | 70825189 |
Lip swelling | 15.24 | 11.17 | 16 | 102475 | 34038 | 70791915 |
Nephropathy toxic | 15.22 | 11.17 | 60 | 102431 | 18454 | 70807499 |
Bacteraemia | 15.21 | 11.17 | 83 | 102408 | 29226 | 70796727 |
Product substitution issue | 15.15 | 11.17 | 4 | 102487 | 18509 | 70807444 |
Herpes simplex | 15.13 | 11.17 | 43 | 102448 | 11189 | 70814764 |
Metastases to central nervous system | 15.12 | 11.17 | 52 | 102439 | 14982 | 70810971 |
Acinetobacter sepsis | 15.04 | 11.17 | 5 | 102486 | 59 | 70825894 |
Cutaneous tuberculosis | 15.02 | 11.17 | 7 | 102484 | 211 | 70825742 |
Malaise | 15.01 | 11.17 | 494 | 101997 | 432438 | 70393515 |
Organic brain syndrome | 15.01 | 11.17 | 9 | 102482 | 457 | 70825496 |
Palpitations | 15.00 | 11.17 | 96 | 102395 | 110657 | 70715296 |
Hypersplenism | 14.99 | 11.17 | 9 | 102482 | 458 | 70825495 |
Device issue | 14.98 | 11.17 | 8 | 102483 | 24017 | 70801936 |
Microangiopathic haemolytic anaemia | 14.97 | 11.17 | 14 | 102477 | 1402 | 70824551 |
Injection site mass | 14.94 | 11.17 | 4 | 102487 | 18339 | 70807614 |
Portal tract inflammation | 14.93 | 11.17 | 6 | 102485 | 125 | 70825828 |
Neck pain | 14.90 | 11.17 | 48 | 102443 | 66609 | 70759344 |
Angioedema | 14.87 | 11.17 | 48 | 102443 | 66562 | 70759391 |
Disseminated aspergillosis | 14.64 | 11.17 | 11 | 102480 | 814 | 70825139 |
Mood altered | 14.59 | 11.17 | 3 | 102488 | 16472 | 70809481 |
Metastatic neoplasm | 14.58 | 11.17 | 25 | 102466 | 4623 | 70821330 |
Gastric varices haemorrhage | 14.57 | 11.17 | 8 | 102483 | 343 | 70825610 |
Dyskinesia | 14.55 | 11.17 | 23 | 102468 | 41051 | 70784902 |
Catheter site thrombosis | 14.55 | 11.17 | 7 | 102484 | 227 | 70825726 |
Iatrogenic infection | 14.54 | 11.17 | 5 | 102486 | 66 | 70825887 |
Dysaesthesia | 14.44 | 11.17 | 27 | 102464 | 5341 | 70820612 |
Pleural fistula | 14.42 | 11.17 | 4 | 102487 | 24 | 70825929 |
Female genital tract fistula | 14.39 | 11.17 | 20 | 102471 | 3083 | 70822870 |
Retinitis viral | 14.38 | 11.17 | 6 | 102485 | 138 | 70825815 |
Cancer fatigue | 14.38 | 11.17 | 6 | 102485 | 138 | 70825815 |
Splenic abscess | 14.33 | 11.17 | 9 | 102482 | 497 | 70825456 |
Adenocarcinoma metastatic | 14.30 | 11.17 | 6 | 102485 | 140 | 70825813 |
C-reactive protein abnormal | 14.25 | 11.17 | 21 | 102470 | 38558 | 70787395 |
Peritoneal disorder | 14.24 | 11.17 | 10 | 102481 | 666 | 70825287 |
Electromyogram abnormal | 14.22 | 11.17 | 6 | 102485 | 142 | 70825811 |
Mydriasis | 14.19 | 11.17 | 3 | 102488 | 16150 | 70809803 |
Neuralgia | 14.17 | 11.17 | 80 | 102411 | 28523 | 70797430 |
Streptococcal bacteraemia | 14.14 | 11.17 | 20 | 102471 | 3133 | 70822820 |
Mental disorder | 14.12 | 11.17 | 12 | 102479 | 28228 | 70797725 |
Drug eruption | 14.11 | 11.17 | 22 | 102469 | 39474 | 70786479 |
Thrombotic thrombocytopenic purpura | 14.10 | 11.17 | 29 | 102462 | 6148 | 70819805 |
Pain in jaw | 14.10 | 11.17 | 25 | 102466 | 42644 | 70783309 |
Hypothyroidism | 14.07 | 11.17 | 28 | 102463 | 45727 | 70780226 |
Hallucination, visual | 14.03 | 11.17 | 13 | 102478 | 29324 | 70796629 |
Transaminases increased | 14.01 | 11.17 | 116 | 102375 | 46902 | 70779051 |
Escherichia bacteraemia | 13.93 | 11.17 | 28 | 102463 | 5841 | 70820112 |
Cardiomyopathy | 13.89 | 11.17 | 75 | 102416 | 26298 | 70799655 |
Product intolerance | 13.89 | 11.17 | 4 | 102487 | 28 | 70825925 |
Gout | 13.85 | 11.17 | 8 | 102483 | 22998 | 70802955 |
Vocal cord paralysis | 13.83 | 11.17 | 17 | 102474 | 2324 | 70823629 |
Therapy cessation | 13.79 | 11.17 | 17 | 102474 | 33659 | 70792294 |
Respiratory disorder | 13.78 | 11.17 | 22 | 102469 | 39101 | 70786852 |
VIth nerve disorder | 13.77 | 11.17 | 4 | 102487 | 29 | 70825924 |
Cerebral toxoplasmosis | 13.76 | 11.17 | 16 | 102475 | 2064 | 70823889 |
Fistula of small intestine | 13.76 | 11.17 | 10 | 102481 | 703 | 70825250 |
Optic neuropathy | 13.76 | 11.17 | 20 | 102471 | 3213 | 70822740 |
Blood glucose decreased | 13.71 | 11.17 | 9 | 102482 | 24150 | 70801803 |
Post procedural diarrhoea | 13.64 | 11.17 | 9 | 102482 | 541 | 70825412 |
Chemotherapeutic drug level above therapeutic | 13.60 | 11.17 | 5 | 102486 | 81 | 70825872 |
Muscle rigidity | 13.53 | 11.17 | 5 | 102486 | 18645 | 70807308 |
Amnesia | 13.53 | 11.17 | 35 | 102456 | 52120 | 70773833 |
Prescribed underdose | 13.51 | 11.17 | 7 | 102484 | 21378 | 70804575 |
Disseminated intravascular coagulation | 13.50 | 11.17 | 89 | 102402 | 33509 | 70792444 |
Ovarian fibroma | 13.49 | 11.17 | 5 | 102486 | 83 | 70825870 |
Rectal haemorrhage | 13.46 | 11.17 | 150 | 102341 | 65681 | 70760272 |
Anal inflammation | 13.45 | 11.17 | 9 | 102482 | 554 | 70825399 |
Benign hydatidiform mole | 13.43 | 11.17 | 5 | 102486 | 84 | 70825869 |
No adverse event | 13.41 | 11.17 | 16 | 102475 | 32137 | 70793816 |
Hepatotoxicity | 13.36 | 11.17 | 109 | 102382 | 43877 | 70782076 |
Hypervolaemia | 13.36 | 11.17 | 23 | 102468 | 39683 | 70786270 |
Radiation hepatitis | 13.34 | 11.17 | 3 | 102488 | 6 | 70825947 |
Ovarian cystectomy | 13.32 | 11.17 | 5 | 102486 | 86 | 70825867 |
Heart rate irregular | 13.28 | 11.17 | 14 | 102477 | 29729 | 70796224 |
Ulcerative gastritis | 13.27 | 11.17 | 5 | 102486 | 87 | 70825866 |
Vitiligo | 13.25 | 11.17 | 15 | 102476 | 1880 | 70824073 |
Toxic encephalopathy | 13.21 | 11.17 | 39 | 102452 | 10367 | 70815586 |
Parkinsonism | 13.15 | 11.17 | 3 | 102488 | 15322 | 70810631 |
Rash maculo-papular | 13.13 | 11.17 | 121 | 102370 | 50424 | 70775529 |
Pancreatic fistula | 13.11 | 11.17 | 5 | 102486 | 90 | 70825863 |
Accidental overdose | 13.09 | 11.17 | 19 | 102472 | 35102 | 70790851 |
Therapy interrupted | 13.08 | 11.17 | 10 | 102481 | 24792 | 70801161 |
Biliary obstruction | 13.08 | 11.17 | 22 | 102469 | 4005 | 70821948 |
Schizophrenia | 13.03 | 11.17 | 4 | 102487 | 16764 | 70809189 |
Lung neoplasm malignant | 13.02 | 11.17 | 10 | 102481 | 24732 | 70801221 |
Metastases to ovary | 12.97 | 11.17 | 7 | 102484 | 290 | 70825663 |
Sciatica | 12.90 | 11.17 | 10 | 102481 | 24617 | 70801336 |
Limbic encephalitis | 12.89 | 11.17 | 10 | 102481 | 776 | 70825177 |
Fear | 12.87 | 11.17 | 7 | 102484 | 20804 | 70805149 |
Hypocapnia | 12.86 | 11.17 | 9 | 102482 | 596 | 70825357 |
Eye disorder | 12.84 | 11.17 | 7 | 102484 | 20778 | 70805175 |
Necrotising colitis | 12.82 | 11.17 | 11 | 102480 | 984 | 70824969 |
Acute endocarditis | 12.81 | 11.17 | 4 | 102487 | 38 | 70825915 |
Toxic leukoencephalopathy | 12.77 | 11.17 | 11 | 102480 | 989 | 70824964 |
Overgrowth fungal | 12.77 | 11.17 | 5 | 102486 | 97 | 70825856 |
Bacterial colitis | 12.77 | 11.17 | 5 | 102486 | 97 | 70825856 |
Upper respiratory tract infection | 12.73 | 11.17 | 65 | 102426 | 79209 | 70746744 |
Disability | 12.72 | 11.17 | 3 | 102488 | 14980 | 70810973 |
Fluid balance positive | 12.72 | 11.17 | 4 | 102487 | 39 | 70825914 |
Sarcoidosis | 12.71 | 11.17 | 29 | 102462 | 6598 | 70819355 |
Granulomatous liver disease | 12.68 | 11.17 | 12 | 102479 | 1220 | 70824733 |
Oesophageal varices haemorrhage | 12.65 | 11.17 | 21 | 102470 | 3782 | 70822171 |
Hypothermia | 12.63 | 11.17 | 7 | 102484 | 20587 | 70805366 |
Sopor | 12.58 | 11.17 | 16 | 102475 | 31251 | 70794702 |
Paraesthesia mucosal | 12.54 | 11.17 | 4 | 102487 | 41 | 70825912 |
Occult blood | 12.50 | 11.17 | 13 | 102478 | 1481 | 70824472 |
Gastric ulcer perforation, obstructive | 12.48 | 11.17 | 3 | 102488 | 9 | 70825944 |
Stomal hernia | 12.42 | 11.17 | 7 | 102484 | 316 | 70825637 |
Drug ineffective for unapproved indication | 12.35 | 11.17 | 23 | 102468 | 38515 | 70787438 |
Ventricular tachycardia | 12.34 | 11.17 | 21 | 102470 | 36402 | 70789551 |
Hemianaesthesia | 12.32 | 11.17 | 8 | 102483 | 468 | 70825485 |
Cellulitis | 12.27 | 11.17 | 88 | 102403 | 98840 | 70727113 |
Pseudocirrhosis | 12.27 | 11.17 | 9 | 102482 | 642 | 70825311 |
Nasal congestion | 12.24 | 11.17 | 51 | 102440 | 65621 | 70760332 |
Dyspnoea exertional | 12.21 | 11.17 | 65 | 102426 | 78365 | 70747588 |
Dysphagia | 12.20 | 11.17 | 230 | 102261 | 112604 | 70713349 |
Anal fistula | 12.19 | 11.17 | 27 | 102464 | 6023 | 70819930 |
Sputum discoloured | 12.16 | 11.17 | 6 | 102485 | 18845 | 70807108 |
Onychoclasis | 12.09 | 11.17 | 24 | 102467 | 4960 | 70820993 |
Endothelial dysfunction | 12.00 | 11.17 | 6 | 102485 | 212 | 70825741 |
Exfoliative rash | 11.99 | 11.17 | 20 | 102471 | 3617 | 70822336 |
Bacterial disease carrier | 11.96 | 11.17 | 11 | 102480 | 1078 | 70824875 |
Oesophageal carcinoma recurrent | 11.90 | 11.17 | 4 | 102487 | 49 | 70825904 |
Fanconi syndrome | 11.86 | 11.17 | 17 | 102474 | 2696 | 70823257 |
Malignant ascites | 11.86 | 11.17 | 11 | 102480 | 1090 | 70824863 |
Sinus bradycardia | 11.86 | 11.17 | 10 | 102481 | 23613 | 70802340 |
Device occlusion | 11.86 | 11.17 | 38 | 102453 | 10557 | 70815396 |
Hand-foot-genital syndrome | 11.81 | 11.17 | 3 | 102488 | 12 | 70825941 |
Axonal and demyelinating polyneuropathy | 11.81 | 11.17 | 3 | 102488 | 12 | 70825941 |
Skin laceration | 11.76 | 11.17 | 12 | 102479 | 25866 | 70800087 |
Abdominal abscess | 11.76 | 11.17 | 28 | 102463 | 6550 | 70819403 |
Neuropathic muscular atrophy | 11.75 | 11.17 | 4 | 102487 | 51 | 70825902 |
Pneumomediastinum | 11.74 | 11.17 | 19 | 102472 | 3351 | 70822602 |
Colitis microscopic | 11.67 | 11.17 | 34 | 102457 | 8971 | 70816982 |
Hyponatraemia | 11.64 | 11.17 | 162 | 102329 | 159925 | 70666028 |
Muscle spasticity | 11.64 | 11.17 | 7 | 102484 | 19682 | 70806271 |
Hepatitis B DNA increased | 11.57 | 11.17 | 9 | 102482 | 701 | 70825252 |
Middle insomnia | 11.57 | 11.17 | 3 | 102488 | 14050 | 70811903 |
Dysphonia | 11.57 | 11.17 | 117 | 102374 | 49983 | 70775970 |
Hepatic fibrosis | 11.55 | 11.17 | 27 | 102464 | 6240 | 70819713 |
Hypercalcaemia | 11.49 | 11.17 | 20 | 102471 | 34365 | 70791588 |
Joint effusion | 11.48 | 11.17 | 4 | 102487 | 15473 | 70810480 |
Dihydropyrimidine dehydrogenase deficiency | 11.45 | 11.17 | 5 | 102486 | 129 | 70825824 |
Granulomatous lymphadenitis | 11.43 | 11.17 | 6 | 102485 | 235 | 70825718 |
Hydronephrosis | 11.42 | 11.17 | 48 | 102443 | 15194 | 70810759 |
Endocarditis | 11.41 | 11.17 | 36 | 102455 | 9918 | 70816035 |
Cytomegalovirus viraemia | 11.39 | 11.17 | 40 | 102451 | 11645 | 70814308 |
Peripheral motor neuropathy | 11.38 | 11.17 | 18 | 102473 | 3114 | 70822839 |
Retroperitoneal abscess | 11.35 | 11.17 | 7 | 102484 | 374 | 70825579 |
Hyperthermia | 11.35 | 11.17 | 51 | 102440 | 16620 | 70809333 |
Glaucoma | 11.31 | 11.17 | 6 | 102485 | 18086 | 70807867 |
Axonal neuropathy | 11.30 | 11.17 | 14 | 102477 | 1930 | 70824023 |
Nephrectasia | 11.27 | 11.17 | 3 | 102488 | 15 | 70825938 |
Drug clearance increased | 11.27 | 11.17 | 6 | 102485 | 242 | 70825711 |
Procedural pain | 11.22 | 11.17 | 6 | 102485 | 18003 | 70807950 |
Movement disorder | 11.18 | 11.17 | 11 | 102480 | 24118 | 70801835 |
None
Source | Code | Description |
---|---|---|
ATC | V03AF03 | VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Detoxifying agents for antineoplastic treatment |
ATC | V03AF06 | VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Detoxifying agents for antineoplastic treatment |
FDA CS | M0008658 | Folic Acid |
MeSH PA | D000931 | Antidotes |
MeSH PA | D018977 | Micronutrients |
MeSH PA | D020011 | Protective Agents |
MeSH PA | D014803 | Vitamin B Complex |
MeSH PA | D014815 | Vitamins |
CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
CHEBI has role | CHEBI:76971 | Escherichia coli metabolites |
FDA EPC | N0000178369 | Folate Analog |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Megaloblastic anemia | indication | 53165003 | DOID:13382 |
Folic acid deficiency | indication | 190633005 | |
Bone Marrow Suppression due to Folic Acid Antagonism | indication | ||
Methotrexate Toxicity | indication | ||
Trimethoprim Toxicity | indication | ||
Trimetrexate Toxicity | indication | ||
Sulfadiazine Toxicity | indication | ||
Pyrimethamine Toxicity | indication | ||
Adjunct to Fluorouracil Treatment of Colorectal Cancer | indication | ||
Pernicious anemia | contraindication | 84027009 | DOID:13381 |
Cobalamin deficiency | contraindication | 190634004 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.61 | acidic |
pKa2 | 5.29 | acidic |
pKa3 | 10.26 | acidic |
pKa4 | 12.96 | acidic |
pKa5 | 4.59 | Basic |
pKa6 | 2.23 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Thymidylate synthase | Enzyme | Ki | 4.07 | WOMBAT-PK | |||||
Dihydrofolate reductase | Enzyme | Ki | 5.63 | CHEMBL |
ID | Source |
---|---|
4019798 | VUID |
N0000147887 | NUI |
D01211 | KEGG_DRUG |
1492-18-8 | SECONDARY_CAS_RN |
4018768 | VANDF |
4019798 | VANDF |
4031236 | VANDF |
C0023413 | UMLSCUI |
CHEBI:15640 | CHEBI |
CHEMBL1679 | ChEMBL_ID |
CHEMBL3707260 | ChEMBL_ID |
CHEMBL1232801 | ChEMBL_ID |
CHEMBL1201138 | ChEMBL_ID |
D002955 | MESH_DESCRIPTOR_UI |
DB00650 | DRUGBANK_ID |
4816 | IUPHAR_LIGAND_ID |
Q573I9DVLP | UNII |
135403648 | PUBCHEM_CID |
225852 | RXNORM |
1728 | MMSL |
39896 | MMSL |
4964 | MMSL |
51342 | MMSL |
d00275 | MMSL |
001050 | NDDF |
001051 | NDDF |
009520 | NDDF |
126223008 | SNOMEDCT_US |
1528001 | SNOMEDCT_US |
396065004 | SNOMEDCT_US |
768550004 | SNOMEDCT_US |
690 | INN_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-4496 | TABLET | 5 mg | ORAL | ANDA | 15 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-4497 | TABLET | 10 mg | ORAL | ANDA | 15 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-4498 | TABLET | 15 mg | ORAL | ANDA | 15 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-4499 | TABLET | 25 mg | ORAL | ANDA | 15 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-8496 | TABLET | 5 mg | ORAL | ANDA | 15 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9368 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 200 mg | INTRAMUSCULAR | ANDA | 19 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9368 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 200 mg | INTRAMUSCULAR | ANDA | 19 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9552 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 350 mg | INTRAMUSCULAR | ANDA | 19 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9553 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 200 mg | INTRAMUSCULAR | ANDA | 19 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9554 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 100 mg | INTRAMUSCULAR | ANDA | 19 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9555 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 50 mg | INTRAMUSCULAR | ANDA | 19 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0484 | TABLET | 5 mg | ORAL | ANDA | 17 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0485 | TABLET | 25 mg | ORAL | ANDA | 17 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-5140 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 100 mg | INTRAMUSCULAR | ANDA | 18 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-5145 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 350 mg | INTRAMUSCULAR | ANDA | 18 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-5145 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 350 mg | INTRAMUSCULAR | ANDA | 18 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6703 | TABLET | 25 mg | ORAL | ANDA | 15 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-813 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 50 mg | INTRAVENOUS | ANDA | 21 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-814 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 100 mg | INTRAVENOUS | ANDA | 21 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-815 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 200 mg | INTRAVENOUS | ANDA | 21 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-816 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 350 mg | INTRAVENOUS | ANDA | 21 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-828 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 21 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42806-133 | TABLET | 10 mg | ORAL | ANDA | 16 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42806-134 | TABLET | 15 mg | ORAL | ANDA | 16 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42806-358 | TABLET | 5 mg | ORAL | ANDA | 16 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42806-359 | TABLET | 25 mg | ORAL | ANDA | 16 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50742-181 | TABLET | 5 mg | ORAL | ANDA | 17 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50742-182 | TABLET | 10 mg | ORAL | ANDA | 17 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50742-183 | TABLET | 15 mg | ORAL | ANDA | 17 sections |
Leucovorin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50742-184 | TABLET | 25 mg | ORAL | ANDA | 17 sections |