leucovorin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1232 58-05-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sodium folinate
  • folinic acid
  • leucovorin
  • calcium folinate
  • leucovorin calcium
  • folinic acid calcium salt
  • folinic acid calcium
  • wellcovorin
  • folinic acid calcium salt pentahydrate
The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.
  • Molecular weight: 473.45
  • Formula: C20H23N7O7
  • CLOGP: -1.98
  • LIPINSKI: 2
  • HAC: 14
  • HDO: 7
  • TPSA: 215.55
  • ALOGS: -3.20
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
60 mg O
60 mg P
60 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 100 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability) 70 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.25 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 5.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.09 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.30 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK1,NTRK2,PDK1,PDK2,PDPK1,PIK3CB,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1 58
kinase-selectivity-class ACVR2B,AXL,BRAF,CDK9,DYRK1B,EIF2AK3,EPHB4,GRK2,GRK3,MAP2K6,MAP3K14,MAPK7,PDK1,SIK2,STK33,TEK,TTK 17
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
June 20, 1952 FDA
Nov. 25, 2021 PMDA PFIZER JAPAN INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 1197.81 10.61 1104 63205 223800 90340338
Neuropathy peripheral 778.14 10.61 698 63611 136272 90427866
Disease progression 517.96 10.61 596 63713 156019 90408119
Mucosal inflammation 515.63 10.61 383 63926 57242 90506896
Thrombocytopenia 486.94 10.61 667 63642 208058 90356080
Neurotoxicity 473.59 10.61 253 64056 21214 90542924
Febrile neutropenia 453.40 10.61 560 63749 157789 90406349
Diarrhoea 419.80 10.61 1537 62772 937653 89626485
Skin toxicity 326.79 10.61 137 64172 6642 90557496
Leukopenia 253.02 10.61 334 63975 100376 90463762
Dermatitis acneiform 249.19 10.61 111 64198 6243 90557895
Polyneuropathy 244.40 10.61 159 64150 19182 90544956
Haematotoxicity 190.89 10.61 116 64193 12419 90551719
Pancytopenia 188.71 10.61 320 63989 119943 90444195
Vomiting 186.09 10.61 1071 63238 787222 89776916
Nausea 185.28 10.61 1382 62927 1108934 89455204
Anaemia 181.06 10.61 606 63703 352196 90211942
Pemphigus 173.52 10.61 16 64293 326848 90237290
Arteriospasm coronary 162.82 10.61 77 64232 4973 90559165
Pulmonary embolism 161.86 10.61 314 63995 130506 90433632
Glossodynia 159.97 10.61 20 64289 321759 90242379
Malignant neoplasm progression 154.12 10.61 274 64035 106596 90457542
Palmar-plantar erythrodysaesthesia syndrome 153.23 10.61 140 64169 27883 90536255
Myelosuppression 149.05 10.61 187 64122 53404 90510734
Systemic lupus erythematosus 144.66 10.61 39 64270 361857 90202281
Non-cirrhotic portal hypertension 140.47 10.61 36 64273 344 90563794
Posterior reversible encephalopathy syndrome 138.84 10.61 120 64189 22219 90541919
Arthropathy 136.33 10.61 45 64264 366197 90197941
Bone marrow failure 134.85 10.61 139 64170 32082 90532056
Swelling 133.94 10.61 65 64244 418993 90145145
Wound 128.17 10.61 29 64280 302951 90261187
Metastases to liver 127.35 10.61 128 64181 28679 90535459
Abdominal pain 124.42 10.61 583 63726 395138 90169000
Loss of employment 122.98 10.61 54 64255 2933 90561205
Synovitis 121.87 10.61 41 64268 329711 90234427
Enteritis 121.04 10.61 81 64228 10240 90553898
Hand deformity 120.20 10.61 31 64278 296331 90267807
Anti-cyclic citrullinated peptide antibody positive 116.73 10.61 15 64294 236418 90327720
Therapy partial responder 114.46 10.61 107 64202 21936 90542202
Drug clearance decreased 114.26 10.61 45 64264 1853 90562285
Pericarditis 110.04 10.61 28 64281 270123 90294015
Peripheral swelling 104.49 10.61 84 64225 413022 90151116
Neoplasm progression 103.19 10.61 142 64167 44344 90519794
Paronychia 101.58 10.61 66 64243 7940 90556198
Gastrointestinal toxicity 100.81 10.61 70 64239 9397 90554741
Colorectal cancer metastatic 99.72 10.61 33 64276 816 90563322
Peripheral sensory neuropathy 97.57 10.61 68 64241 9182 90554956
Portal hypertension 96.93 10.61 53 64256 4648 90559490
Duodenal ulcer perforation 95.96 10.61 20 64289 221268 90342870
Dehydration 95.15 10.61 329 63980 194118 90370020
Helicobacter infection 93.37 10.61 23 64286 226827 90337311
Focal nodular hyperplasia 90.65 10.61 30 64279 742 90563396
Rheumatoid factor positive 89.45 10.61 9 64300 171641 90392497
Irritable bowel syndrome 89.43 10.61 19 64290 207429 90356709
Injury 87.31 10.61 17 64292 197332 90366806
Dysarthria 85.43 10.61 145 64164 54337 90509801
Product dose omission issue 84.73 10.61 51 64258 291636 90272502
Proteinuria 84.24 10.61 93 64216 23198 90540940
Mobility decreased 82.97 10.61 37 64272 250697 90313441
Discomfort 82.48 10.61 46 64263 274289 90289849
Wheezing 82.19 10.61 33 64276 238047 90326091
Rash pustular 82.18 10.61 58 64251 7991 90556147
Hypomagnesaemia 80.14 10.61 112 64197 35476 90528662
Folliculitis 79.77 10.61 23 64286 204330 90359808
Leukoencephalopathy 79.12 10.61 47 64262 4826 90559312
Lower respiratory tract infection 78.33 10.61 40 64269 250619 90313519
Blister 77.75 10.61 42 64267 254956 90309182
Insomnia 74.51 10.61 76 64233 333398 90230740
Hyperammonaemic encephalopathy 74.49 10.61 37 64272 2662 90561476
Sepsis 74.26 10.61 288 64021 179526 90384612
Type 2 diabetes mellitus 73.78 10.61 26 64283 203218 90360920
Gastrointestinal perforation 73.53 10.61 43 64266 4289 90559849
Ascites 73.45 10.61 126 64183 47614 90516524
Blood cholesterol increased 73.17 10.61 28 64281 207984 90356154
Muscle injury 72.51 10.61 18 64291 176636 90387502
Joint swelling 70.59 10.61 158 64151 503142 90060996
Metastases to lung 70.57 10.61 71 64238 15920 90548218
Human bocavirus infection 70.41 10.61 22 64287 450 90563688
Sleep disorder 69.08 10.61 27 64282 198003 90366135
Splenomegaly 65.68 10.61 62 64247 12862 90551276
Septic shock 65.58 10.61 168 64141 83992 90480146
Memory impairment 65.41 10.61 29 64280 197215 90366923
Neutrophil count decreased 64.46 10.61 151 64158 71381 90492757
Stomatitis 64.24 10.61 373 63936 274325 90289813
Gene mutation 64.17 10.61 31 64278 2099 90562039
Abdominal discomfort 63.59 10.61 154 64155 477174 90086964
Interstitial lung disease 63.17 10.61 156 64153 76249 90487889
Impaired healing 61.21 10.61 46 64263 234153 90329985
Trichomegaly 60.63 10.61 14 64295 82 90564056
Hepatocellular injury 60.59 10.61 88 64221 28870 90535268
Hepatic enzyme increased 60.31 10.61 102 64207 360634 90203504
Hypokalaemia 59.93 10.61 217 64092 130899 90433239
Ductal adenocarcinoma of pancreas 59.04 10.61 15 64294 138 90564000
Thrombocytopenic purpura 58.84 10.61 28 64281 1833 90562305
Secondary immunodeficiency 58.24 10.61 29 64280 2097 90562041
Chills 56.61 10.61 214 64095 131767 90432371
Intestinal perforation 56.48 10.61 59 64250 13822 90550316
Pyrexia 56.15 10.61 715 63594 659770 89904368
Sleep disorder due to general medical condition, insomnia type 55.02 10.61 12 64297 128682 90435456
Rheumatic fever 54.87 10.61 20 64289 153101 90411037
Weight increased 53.96 10.61 137 64172 417790 90146348
Device related infection 53.42 10.61 78 64231 25708 90538430
Fibromyalgia 53.28 10.61 41 64268 206228 90357910
Ileus 52.93 10.61 62 64247 16484 90547654
Pneumatosis intestinalis 52.82 10.61 32 64277 3405 90560733
Fall 52.64 10.61 171 64138 481639 90082499
Depression 52.09 10.61 83 64226 300518 90263620
Migraine 51.57 10.61 36 64273 190356 90373782
Laryngospasm 51.14 10.61 31 64278 3302 90560836
Asthma 49.86 10.61 59 64250 242101 90322037
Epistaxis 49.67 10.61 153 64156 84972 90479166
Hypersensitivity vasculitis 49.63 10.61 33 64276 4126 90560012
Cholangitis 49.59 10.61 41 64268 7141 90556997
Swollen joint count increased 48.29 10.61 10 64299 111196 90452942
Haemolytic uraemic syndrome 47.97 10.61 28 64281 2783 90561355
Steatohepatitis 47.91 10.61 19 64290 797 90563341
Acute kidney injury 47.49 10.61 389 63920 319998 90244140
Enterobacter infection 47.47 10.61 27 64282 2556 90561582
Cardiotoxicity 47.40 10.61 49 64260 11340 90552798
Hyperammonaemia 46.89 10.61 38 64271 6437 90557701
Herpes simplex 46.39 10.61 46 64263 10135 90554003
Hypercholesterolaemia 46.09 10.61 8 64301 100884 90463254
Contraindicated product administered 46.07 10.61 99 64210 320040 90244098
Hepatic steatosis 46.03 10.61 89 64220 36856 90527282
Cystitis radiation 45.58 10.61 11 64298 80 90564058
Venous thrombosis 45.48 10.61 35 64274 5502 90558636
Mucosal toxicity 44.72 10.61 15 64294 387 90563751
Tumour lysis syndrome 44.66 10.61 47 64262 11105 90553033
Metastases to ovary 44.48 10.61 16 64293 511 90563627
Second primary malignancy 43.83 10.61 45 64264 10333 90553805
Large intestinal obstruction 43.60 10.61 26 64283 2688 90561450
C-reactive protein abnormal 43.41 10.61 18 64291 127411 90436727
Pain 43.11 10.61 476 63833 995865 89568273
Myelodysplastic syndrome 42.97 10.61 63 64246 20840 90543298
Encephalopathy 42.88 10.61 99 64210 46345 90517793
Ill-defined disorder 42.57 10.61 41 64268 184850 90379288
Breast cancer stage III 42.53 10.61 5 64304 84442 90479696
Psoriatic arthropathy 42.50 10.61 60 64249 228275 90335863
Joint range of motion decreased 41.82 10.61 22 64287 135621 90428517
Pharyngeal dyskinesia 41.81 10.61 9 64300 36 90564102
Embolism 41.66 10.61 42 64267 9439 90554699
Crystal nephropathy 41.61 10.61 19 64290 1132 90563006
Gastroenteritis norovirus 41.43 10.61 24 64285 2352 90561786
Deep vein thrombosis 41.32 10.61 151 64158 91469 90472669
Drug abuse 41.16 10.61 5 64304 82342 90481796
Cholestasis 41.08 10.61 84 64225 36215 90527923
Venous pressure jugular decreased 41.04 10.61 9 64300 40 90564098
Intestinal obstruction 40.93 10.61 85 64224 37046 90527092
Sinusitis 40.85 10.61 117 64192 342971 90221167
Leukoerythroblastosis 40.25 10.61 13 64296 297 90563841
Subretinal haematoma 39.23 10.61 9 64300 51 90564087
Hospitalisation 39.17 10.61 21 64288 128079 90436059
Maternal exposure during pregnancy 39.15 10.61 128 64181 359935 90204203
Grip strength decreased 38.83 10.61 9 64300 92567 90471571
Metastases to meninges 38.33 10.61 27 64282 3708 90560430
T-cell lymphoma refractory 37.98 10.61 9 64300 60 90564078
Stress cardiomyopathy 37.75 10.61 47 64262 13308 90550830
Obesity 37.42 10.61 14 64295 105493 90458645
Venoocclusive liver disease 36.84 10.61 32 64277 5961 90558177
Mouth ulceration 36.68 10.61 85 64224 39889 90524249
Laryngeal dyspnoea 35.48 10.61 11 64298 219 90563919
Rash maculo-papular 35.34 10.61 85 64224 40848 90523290
Hypertension 35.34 10.61 487 63822 457045 90107093
Bladder tamponade 35.15 10.61 10 64299 146 90563992
Nasopharyngitis 35.07 10.61 159 64150 406945 90157193
Exposure during pregnancy 34.89 10.61 73 64236 238337 90325801
Atypical haemolytic uraemic syndrome 34.70 10.61 16 64293 975 90563163
Peritoneal disorder 34.35 10.61 14 64295 631 90563507
Drug hypersensitivity 34.27 10.61 191 64118 463418 90100720
Fluid retention 34.20 10.61 10 64299 88081 90476057
Gastric varices haemorrhage 34.18 10.61 10 64299 162 90563976
Prescribed underdose 34.15 10.61 6 64303 75013 90489125
Encapsulating peritoneal sclerosis 34.10 10.61 12 64297 359 90563779
Large intestine perforation 33.78 10.61 38 64271 9674 90554464
Confusional state 33.77 10.61 150 64159 386055 90178083
Ocular toxicity 33.43 10.61 16 64293 1061 90563077
Cholinergic syndrome 33.32 10.61 14 64295 682 90563456
Immune thrombocytopenia 33.12 10.61 44 64265 13282 90550856
Colitis 33.00 10.61 117 64192 69825 90494313
Peritonitis 32.96 10.61 54 64255 19651 90544487
Factor VII deficiency 32.82 10.61 8 64301 61 90564077
Haemolytic anaemia 32.80 10.61 41 64268 11656 90552482
Neuromyotonia 32.59 10.61 8 64301 63 90564075
Nasal septum perforation 32.04 10.61 14 64295 751 90563387
Dizziness 32.01 10.61 266 64043 589018 89975120
Pruritus 31.94 10.61 239 64070 541286 90022852
Pain in extremity 31.48 10.61 189 64120 450340 90113798
Multiple organ dysfunction syndrome 31.12 10.61 113 64196 68223 90495915
Treatment failure 31.02 10.61 111 64198 303817 90260321
Injection site pain 30.99 10.61 47 64262 173652 90390486
Anastomotic leak 30.93 10.61 13 64296 634 90563504
Gastrointestinal stoma complication 30.83 10.61 20 64289 2399 90561739
Aortic thrombosis 30.44 10.61 16 64293 1296 90562842
Contusion 30.38 10.61 85 64224 251131 90313007
Short-bowel syndrome 30.34 10.61 13 64296 665 90563473
Nodular regenerative hyperplasia 30.25 10.61 13 64296 670 90563468
Lip dry 30.21 10.61 17 64292 100938 90463200
Nicotinic acid deficiency 30.20 10.61 8 64301 88 90564050
Disease recurrence 30.19 10.61 76 64233 37577 90526561
Psychiatric decompensation 29.63 10.61 18 64291 1925 90562213
Adverse event 29.48 10.61 24 64285 117394 90446744
Neutropenic colitis 29.34 10.61 24 64285 4119 90560019
Urticaria 28.84 10.61 119 64190 312615 90251523
Facet joint syndrome 28.82 10.61 17 64292 98372 90465766
Off label use 28.48 10.61 1001 63308 1101251 89462887
Gait inability 27.73 10.61 38 64271 146418 90417720
Petechiae 27.50 10.61 44 64265 15697 90548441
Vena cava thrombosis 27.48 10.61 19 64290 2533 90561605
Product quality issue 27.35 10.61 11 64298 79314 90484824
Dry mouth 27.23 10.61 56 64253 184003 90380135
Hip arthroplasty 27.21 10.61 10 64299 76198 90487940
Prescribed overdose 27.04 10.61 18 64291 97607 90466531
Varices oesophageal 26.99 10.61 22 64287 3757 90560381
Colon cancer recurrent 26.94 10.61 7 64302 71 90564067
Intentional product misuse 26.94 10.61 15 64294 89589 90474549
Human herpesvirus 6 infection 26.68 10.61 21 64288 3411 90560727
Asthenia 26.67 10.61 529 63780 533222 90030916
Dislocation of vertebra 26.54 10.61 4 64305 55964 90508174
Carcinoembryonic antigen increased 26.49 10.61 18 64291 2332 90561806
Overgrowth fungal 26.41 10.61 8 64301 147 90563991
Knee arthroplasty 26.37 10.61 13 64296 83169 90480969
Psoriasis 26.33 10.61 40 64269 147714 90416424
Dyspepsia 26.28 10.61 64 64245 198096 90366042
Amnesia 26.23 10.61 23 64286 108482 90455656
General physical health deterioration 26.19 10.61 375 63934 354740 90209398
Superior vena cava syndrome 26.18 10.61 12 64297 721 90563417
Portal vein thrombosis 26.13 10.61 20 64289 3118 90561020
Gastrooesophageal reflux disease 25.99 10.61 49 64260 166288 90397850
Subileus 25.57 10.61 21 64288 3623 90560515
Neoplasm recurrence 25.46 10.61 20 64289 3239 90560899
Rhinovirus infection 25.44 10.61 26 64283 5937 90558201
Metastases to peritoneum 25.17 10.61 22 64287 4133 90560005
Clostridium difficile colitis 24.73 10.61 57 64252 26649 90537489
Electrolyte imbalance 24.60 10.61 53 64256 23692 90540446
Hypocalcaemia 24.56 10.61 76 64233 42292 90521846
Nail disorder 24.26 10.61 6 64303 59061 90505077
Blood pressure fluctuation 24.15 10.61 87 64222 52326 90511812
Pleuroparenchymal fibroelastosis 24.02 10.61 8 64301 202 90563936
Jugular vein thrombosis 23.81 10.61 20 64289 3561 90560577
Inferior vena cava stenosis 23.64 10.61 5 64304 18 90564120
Pneumonitis 23.57 10.61 77 64232 44093 90520045
Electrocardiogram QT prolonged 23.47 10.61 11 64298 72445 90491693
Aortic intramural haematoma 23.45 10.61 7 64302 122 90564016
Hypoaesthesia 23.44 10.61 129 64180 314081 90250057
Adverse drug reaction 23.40 10.61 29 64280 116672 90447466
Myeloid leukaemia 23.38 10.61 10 64299 509 90563629
Growth of eyelashes 23.17 10.61 8 64301 226 90563912
Metastasis 23.05 10.61 25 64284 6112 90558026
Mixed adenoneuroendocrine carcinoma 23.03 10.61 5 64304 21 90564117
Wrong technique in product usage process 22.97 10.61 11 64298 71560 90492578
Post procedural diarrhoea 22.91 10.61 9 64300 368 90563770
Jugular vein occlusion 22.90 10.61 6 64303 63 90564075
Dysphagia 22.75 10.61 147 64162 112131 90452007
Sciatica 22.73 10.61 23 64286 101359 90462779
Meningitis streptococcal 22.64 10.61 7 64302 138 90564000
Tumour necrosis 22.64 10.61 12 64297 989 90563149
Febrile bone marrow aplasia 22.45 10.61 31 64278 9707 90554431
Depilation 22.32 10.61 5 64304 25 90564113
Metastases to lymph nodes 22.27 10.61 34 64275 11655 90552483
Occult blood 22.22 10.61 13 64296 1298 90562840
K-ras gene mutation 22.15 10.61 5 64304 26 90564112
X-ray abnormal 22.12 10.61 3 64306 45421 90518717
Gastrointestinal anastomotic leak 22.08 10.61 8 64301 261 90563877
Drug resistance 21.89 10.61 59 64250 30390 90533748
Lupus vulgaris 21.88 10.61 3 64306 45056 90519082
Portal vein dilatation 21.69 10.61 5 64304 29 90564109
Upper respiratory tract infection 21.67 10.61 36 64273 128282 90435856
Joint dislocation 21.57 10.61 3 64306 44579 90519559
Small intestinal obstruction 21.54 10.61 47 64262 21187 90542951
Adenocarcinoma of colon 21.45 10.61 17 64292 2789 90561349
Hepatic cirrhosis 21.43 10.61 9 64300 63244 90500894
ECG signs of myocardial ischaemia 21.39 10.61 6 64303 83 90564055
Suicidal ideation 21.30 10.61 13 64296 73842 90490296
Acute promyelocytic leukaemia 21.28 10.61 12 64297 1117 90563021
Chronic obstructive pulmonary disease 21.28 10.61 13 64296 73816 90490322
Pneumothorax 21.27 10.61 44 64265 19123 90545015
Acute polyneuropathy 21.16 10.61 9 64300 452 90563686
Hepatitis toxic 21.12 10.61 19 64290 3706 90560432
Hepatic failure 20.97 10.61 69 64240 39659 90524479
Thrombotic microangiopathy 20.94 10.61 39 64270 15704 90548434
Respiratory symptom 20.85 10.61 20 64289 4232 90559906
Cardiomyopathy 20.81 10.61 45 64264 20161 90543977
Wound infection 20.76 10.61 27 64282 106375 90457763
Systemic infection 20.70 10.61 21 64288 4754 90559384
Hypoalbuminaemia 20.67 10.61 39 64270 15858 90548280
Back injury 20.64 10.61 4 64305 46618 90517520
Gait disturbance 20.51 10.61 105 64204 260391 90303747
Cytopenia 20.48 10.61 41 64268 17408 90546730
Loss of personal independence in daily activities 20.48 10.61 41 64268 136064 90428074
Oesophageal fistula 20.47 10.61 7 64302 192 90563946
Pneumothorax spontaneous 20.44 10.61 11 64298 934 90563204
Cutaneous tuberculosis 20.43 10.61 7 64302 193 90563945
Intentional product use issue 20.32 10.61 82 64227 216810 90347328
Venous thrombosis limb 20.31 10.61 18 64291 3444 90560694
Onychomadesis 20.25 10.61 4 64305 45994 90518144
Craniocervical syndrome 20.13 10.61 6 64303 104 90564034
Red cell fragmentation syndrome 20.08 10.61 5 64304 42 90564096
Arthralgia 20.04 10.61 411 63898 778111 89786027
Peripheral venous disease 20.03 10.61 18 64291 83903 90480235
Lupus-like syndrome 19.99 10.61 5 64304 48841 90515297
Type II hypersensitivity 19.98 10.61 5 64304 43 90564095
Alopecia 19.96 10.61 240 64069 494831 90069307
Gastroenteritis aeromonas 19.88 10.61 5 64304 44 90564094
Stomal varices 19.73 10.61 4 64305 11 90564127
No adverse event 19.55 10.61 12 64297 67970 90496168
Gastric cancer 19.42 10.61 21 64288 5115 90559023
Prinzmetal angina 19.41 10.61 11 64298 1034 90563104
Pelvic fluid collection 19.27 10.61 11 64298 1048 90563090
Respiratory disorder 19.27 10.61 11 64298 64805 90499333
Enterocolitis 19.26 10.61 30 64279 10460 90553678
Medication error 19.21 10.61 19 64290 84633 90479505
Transaminases increased 19.10 10.61 64 64245 37128 90527010
Acute myeloid leukaemia 19.05 10.61 44 64265 20596 90543542
Drug reaction with eosinophilia and systemic symptoms 18.87 10.61 70 64239 42688 90521450
Gastrointestinal stoma output increased 18.76 10.61 9 64300 600 90563538
Colon cancer metastatic 18.73 10.61 12 64297 1409 90562729
Bursitis 18.68 10.61 41 64268 131613 90432525
Face oedema 18.62 10.61 47 64262 23271 90540867
Hypertrichosis 18.29 10.61 12 64297 1467 90562671
Klebsiella infection 18.29 10.61 29 64280 10268 90553870
Liver abscess 18.20 10.61 17 64292 3479 90560659
Chemotherapeutic drug level above therapeutic 17.97 10.61 5 64304 67 90564071
Cytokine release syndrome 17.94 10.61 52 64257 27921 90536217
Musculoskeletal stiffness 17.87 10.61 130 64179 296402 90267736
Sedation 17.75 10.61 6 64303 48165 90515973
White blood cell count decreased 17.72 10.61 189 64120 166920 90397218
Hepatic lesion 17.72 10.61 21 64288 5652 90558486
Laryngitis 17.55 10.61 7 64302 50746 90513392
Gastrointestinal necrosis 17.41 10.61 16 64293 3209 90560929
Throat tightness 17.19 10.61 53 64256 29431 90534707
Lymphopenia 17.12 10.61 45 64264 22836 90541302
Rotator cuff syndrome 17.03 10.61 36 64273 15883 90548255
Hypocapnia 16.97 10.61 8 64301 513 90563625
Portal shunt 16.97 10.61 4 64305 26 90564112
Hepatotoxicity 16.96 10.61 71 64238 45771 90518367
Pneumonia 16.96 10.61 335 63974 637724 89926414
Peripheral sensorimotor neuropathy 16.96 10.61 13 64296 2032 90562106
Agranulocytosis 16.89 10.61 59 64250 34943 90529195
Pelvic abscess 16.88 10.61 13 64296 2045 90562093
Escherichia pyelonephritis 16.85 10.61 9 64300 753 90563385
Bacteraemia 16.83 10.61 44 64265 22256 90541882
Failure to thrive 16.78 10.61 25 64284 8386 90555752
Hyperbilirubinaemia 16.66 10.61 33 64276 13903 90550235
Cystitis bacterial 16.60 10.61 7 64302 344 90563794
Vitiligo 16.60 10.61 13 64296 2097 90562041
Rhinocerebral mucormycosis 16.31 10.61 9 64300 803 90563335
Liver function test increased 16.07 10.61 22 64287 84833 90479305
Hepatic vein stenosis 16.03 10.61 4 64305 34 90564104
Cachexia 16.01 10.61 22 64287 6856 90557282
Pneumonia parainfluenzae viral 16.00 10.61 7 64302 377 90563761
Subacute cutaneous lupus erythematosus 15.98 10.61 16 64293 3566 90560572
Anal erosion 15.82 10.61 4 64305 36 90564102
Walking aid user 15.81 10.61 3 64306 35503 90528635
Optic neuropathy 15.77 10.61 14 64295 2684 90561454
Granulomatous lymphadenitis 15.72 10.61 6 64303 227 90563911
Breast cancer stage II 15.71 10.61 3 64306 35331 90528807
Metastases to bone marrow 15.66 10.61 8 64301 611 90563527
Oedema 15.61 10.61 81 64228 200214 90363924
Joint noise 15.57 10.61 19 64290 5271 90558867
Product intolerance 15.53 10.61 4 64305 39 90564099
Blood creatinine increased 15.47 10.61 124 64185 101262 90462876
Optic disc hyperaemia 15.46 10.61 3 64306 6 90564132
Mucosal disorder 15.45 10.61 14 64295 2757 90561381
Macular degeneration 15.32 10.61 4 64305 37966 90526172
Vaginal infection 15.31 10.61 24 64285 8416 90555722
Administration site extravasation 15.26 10.61 10 64299 1220 90562918
Reticulocytosis 15.24 10.61 6 64303 247 90563891
Minimal residual disease 15.17 10.61 7 64302 427 90563711
Hypophagia 15.17 10.61 58 64251 35879 90528259
Disability 15.14 10.61 5 64304 40740 90523398
Platelet count decreased 15.03 10.61 156 64153 136813 90427325
Respiratory failure 15.01 10.61 139 64170 118279 90445859
Jaundice 15.00 10.61 54 64255 32463 90531675
Anxiety 14.95 10.61 144 64165 309628 90254510
Tubular breast carcinoma 14.94 10.61 4 64305 46 90564092
Taste disorder 14.93 10.61 13 64296 61533 90502605
Acquired gene mutation 14.90 10.61 10 64299 1269 90562869
Epilepsy 14.89 10.61 22 64287 82184 90481954
Granulocyte count decreased 14.89 10.61 13 64296 2439 90561699
Left ventricular hypertrophy 14.83 10.61 20 64289 6124 90558014
Hemiparesis 14.81 10.61 53 64256 31766 90532372
Illness 14.79 10.61 22 64287 81947 90482191
Cardiac failure 14.63 10.61 130 64179 109366 90454772
Proctalgia 14.44 10.61 23 64286 8175 90555963
Intestinal ischaemia 14.39 10.61 24 64285 8859 90555279
Escherichia bacteraemia 14.35 10.61 19 64290 5716 90558422
Cardiomyopathy acute 14.32 10.61 6 64303 290 90563848
Tumour perforation 14.26 10.61 5 64304 148 90563990
Sensorimotor disorder 14.17 10.61 8 64301 747 90563391
Death 14.14 10.61 424 63885 456127 90108011
Clostridium difficile infection 14.09 10.61 57 64252 36188 90527950
Ataxia 14.03 10.61 36 64273 18006 90546132
Foot deformity 13.99 10.61 13 64296 59638 90504500
Multiple-drug resistance 13.95 10.61 22 64287 7754 90556384
Flushing 13.92 10.61 109 64200 88382 90475756
Rectal perforation 13.87 10.61 7 64302 521 90563617
Therapeutic product effect decreased 13.83 10.61 128 64181 277443 90286695
Retinitis 13.81 10.61 5 64304 38453 90525685
Apraxia 13.75 10.61 12 64297 2250 90561888
Endometrial dysplasia 13.74 10.61 3 64306 13 90564125
Periportal sinus dilatation 13.74 10.61 3 64306 13 90564125
Coagulopathy 13.71 10.61 42 64267 23247 90540891
Hallucination 13.64 10.61 16 64293 65943 90498195
Abortion spontaneous 13.62 10.61 11 64298 54045 90510093
Procedural site reaction 13.61 10.61 6 64303 329 90563809
Tubal rupture 13.56 10.61 3 64306 14 90564124
Live birth 13.54 10.61 22 64287 79085 90485053
Bicytopenia 13.53 10.61 15 64294 3756 90560382
Toxic encephalopathy 13.43 10.61 23 64286 8676 90555462
Pharyngotonsillitis 13.41 10.61 5 64304 177 90563961
Eczema asteatotic 13.37 10.61 6 64303 343 90563795
Hypertensive crisis 13.33 10.61 35 64274 17749 90546389
Ear infection 13.31 10.61 18 64291 69757 90494381
Ovarian cystectomy 13.31 10.61 5 64304 181 90563957
Benign hydatidiform mole 13.18 10.61 5 64304 186 90563952
Cognitive disorder 13.14 10.61 18 64291 69389 90494749
Blood phosphorus decreased 13.10 10.61 17 64292 5017 90559121
Joint stiffness 13.08 10.61 22 64287 78020 90486118
Bacteriuria 13.03 10.61 9 64300 1197 90562941
Blood culture positive 12.99 10.61 17 64292 5055 90559083
Vaginal fistula 12.99 10.61 7 64302 596 90563542
Aplasia 12.84 10.61 15 64294 3976 90560162
Hemianaesthesia 12.82 10.61 6 64303 378 90563760
Bronchospasm 12.80 10.61 38 64271 20671 90543467
Overdose 12.73 10.61 63 64246 157646 90406492
Endothelial dysfunction 12.69 10.61 5 64304 206 90563932
Optic nerve disorder 12.69 10.61 9 64300 1249 90562889
Muscle atrophy 12.69 10.61 22 64287 8379 90555759
Frequent bowel movements 12.67 10.61 13 64296 56922 90507216
Anaemia of malignant disease 12.66 10.61 7 64302 627 90563511
Bacterial infection 12.62 10.61 41 64268 23403 90540735
Gastric haemorrhage 12.61 10.61 20 64289 7083 90557055
Headache 12.55 10.61 493 63816 862253 89701885
Granulomatous liver disease 12.47 10.61 8 64301 941 90563197
Cerebral ischaemia 12.41 10.61 20 64289 7176 90556962
Subclavian vein thrombosis 12.41 10.61 11 64298 2105 90562033
Mitral valve disease 12.39 10.61 12 64297 2570 90561568
Visual acuity reduced transiently 12.34 10.61 5 64304 222 90563916
Left ventricular end-diastolic pressure increased 12.30 10.61 6 64303 415 90563723
Anal infection 12.24 10.61 4 64305 95 90564043
Irritability 12.20 10.61 5 64304 35657 90528481
Stridor 12.18 10.61 16 64293 4777 90559361
Nephrotic syndrome 12.12 10.61 20 64289 7319 90556819
Aortitis 12.12 10.61 9 64300 1341 90562797
Metastases to spleen 12.11 10.61 5 64304 233 90563905
Dermatitis 12.09 10.61 39 64270 22181 90541957
Central nervous system lupus 12.04 10.61 9 64300 1354 90562784
Norovirus test positive 12.01 10.61 5 64304 238 90563900
Injection site reaction 12.00 10.61 30 64279 92050 90472088
Immunodeficiency 11.93 10.61 8 64301 43226 90520912
Persecutory delusion 11.93 10.61 13 64296 3195 90560943
Neutropenic sepsis 11.91 10.61 34 64275 18096 90546042
Myocardial oedema 11.91 10.61 6 64303 445 90563693
Dysplasia 11.86 10.61 9 64300 1385 90562753
Intracranial pressure increased 11.85 10.61 19 64290 6792 90557346
Tumour rupture 11.78 10.61 5 64304 250 90563888
Productive cough 11.77 10.61 23 64286 77040 90487098
Depressed mood 11.71 10.61 11 64298 50211 90513927
Pelvic mass 11.71 10.61 9 64300 1412 90562726
Peripheral nerve injury 11.67 10.61 7 64302 732 90563406
Renal failure 11.57 10.61 143 64166 130864 90433274
Duodenal obstruction 11.52 10.61 5 64304 264 90563874
Bacterial translocation 11.52 10.61 7 64302 749 90563389
Tumour fistulisation 11.49 10.61 3 64306 31 90564107
Protein urine present 11.49 10.61 19 64290 6965 90557173
Retroperitoneal lymphadenopathy 11.48 10.61 7 64302 753 90563385
Jejunal ulcer 11.48 10.61 4 64305 116 90564022
Transposition of the great vessels 11.45 10.61 5 64304 268 90563870
Gastroenteritis 11.39 10.61 46 64263 29183 90534955
Dihydropyrimidine dehydrogenase deficiency 11.36 10.61 4 64305 120 90564018
Vitamin K deficiency 11.27 10.61 6 64303 499 90563639
Emotional distress 11.22 10.61 6 64303 36656 90527482
Visual impairment 11.19 10.61 52 64257 132313 90431825
Left ventricular dysfunction 11.13 10.61 29 64280 14640 90549498
Hypoacusis 11.11 10.61 3 64306 27847 90536291
Condition aggravated 11.05 10.61 330 63979 595215 89968923
Neuralgia 11.04 10.61 48 64261 31452 90532686
Extravasation 11.00 10.61 12 64297 2952 90561186
Anastomotic fistula 10.94 10.61 3 64306 38 90564100
Basal cell carcinoma 10.92 10.61 5 64304 33384 90530754
Enterocutaneous fistula 10.90 10.61 9 64300 1565 90562573
Balance disorder 10.89 10.61 34 64275 97046 90467092
Biliary tract infection 10.81 10.61 7 64302 837 90563301
Conjunctival disorder 10.81 10.61 5 64304 307 90563831
Autoimmune disorder 10.80 10.61 24 64285 76720 90487418
Toxicity to various agents 10.78 10.61 274 64035 287572 90276566
Enterocolitis infectious 10.75 10.61 10 64299 2037 90562101
Neuroendocrine carcinoma of the skin 10.70 10.61 7 64302 851 90563287
Cardiac myxoma 10.70 10.61 5 64304 314 90563824
Electrocardiogram abnormal 10.68 10.61 23 64286 10275 90553863
Mucocutaneous disorder 10.66 10.61 3 64306 42 90564096
Unevaluable event 10.61 10.61 14 64295 54834 90509304

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 1009.01 12.70 1447 70456 197984 42351448
Neuropathy peripheral 734.40 12.70 881 71022 100972 42448460
Skin toxicity 685.60 12.70 295 71608 6254 42543178
Diarrhoea 572.38 12.70 1887 70016 458962 42090470
Disease progression 488.35 12.70 871 71032 142785 42406647
Dermatitis acneiform 428.91 12.70 225 71678 7514 42541918
Mucosal inflammation 405.22 12.70 457 71446 48917 42500515
Neurotoxicity 403.46 12.70 328 71575 23323 42526109
Metastases to liver 349.36 12.70 259 71644 16067 42533365
Thrombocytopenia 337.79 12.70 887 71016 189392 42360040
Stomatitis 307.12 12.70 401 71502 49928 42499504
Palmar-plantar erythrodysaesthesia syndrome 294.51 12.70 258 71645 20324 42529108
Polyneuropathy 277.25 12.70 239 71664 18422 42531010
Arteriospasm coronary 260.38 12.70 137 71766 4601 42544831
Gastrointestinal toxicity 193.28 12.70 106 71797 3873 42545559
Paronychia 175.94 12.70 102 71801 4153 42545279
Leukopenia 171.30 12.70 385 71518 74361 42475071
Neoplasm progression 164.41 12.70 223 71680 28777 42520655
Product dose omission issue 163.81 12.70 31 71872 154334 42395098
Metastases to lung 158.98 12.70 141 71762 11283 42538149
Febrile neutropenia 152.72 12.70 669 71234 185034 42364398
Rash pustular 152.10 12.70 107 71796 6108 42543324
Carcinoembryonic antigen increased 151.31 12.70 57 71846 841 42548591
Haematotoxicity 149.72 12.70 134 71769 10851 42538581
Skin reaction 146.42 12.70 110 71793 6957 42542475
Pyrexia 142.31 12.70 1142 70761 392900 42156532
Completed suicide 140.50 12.70 5 71898 96460 42452972
Peripheral sensory neuropathy 139.90 12.70 117 71786 8645 42540787
Nausea 138.43 12.70 1141 70762 395658 42153774
Proteinuria 135.26 12.70 180 71723 22803 42526629
Portal hypertension 120.84 12.70 84 71819 4703 42544729
Bone marrow failure 120.25 12.70 207 71696 32886 42516546
Chills 117.05 12.70 387 71516 93679 42455753
Myelosuppression 115.41 12.70 228 71675 40233 42509199
Drug abuse 113.34 12.70 20 71883 104751 42444681
Drug ineffective 110.73 12.70 619 71284 629578 41919854
Therapy partial responder 110.50 12.70 152 71751 19869 42529563
Decreased appetite 109.23 12.70 626 71277 192511 42356921
Malignant neoplasm progression 109.16 12.70 416 71487 107984 42441448
Cardiotoxicity 105.80 12.70 93 71810 7352 42542080
Vomiting 99.64 12.70 831 71072 288892 42260540
Hyperammonaemia 95.60 12.70 90 71813 7776 42541656
Hypomagnesaemia 94.20 12.70 171 71732 28317 42521115
Colorectal cancer metastatic 93.08 12.70 41 71862 920 42548512
Cardiac failure congestive 91.15 12.70 17 71886 85585 42463847
General physical health deterioration 87.92 12.70 494 71409 150752 42398680
Myalgia 85.05 12.70 28 71875 96052 42453380
Intestinal obstruction 84.74 12.70 159 71744 26999 42522433
Abdominal pain 83.73 12.70 579 71324 189892 42359540
Interstitial lung disease 81.33 12.70 304 71599 78158 42471274
Leukoencephalopathy 78.77 12.70 66 71837 4888 42544544
Rhabdomyolysis 77.90 12.70 18 71885 78001 42471431
Alopecia 77.55 12.70 160 71743 29116 42520316
Rectal tenesmus 77.06 12.70 38 71865 1110 42548322
Febrile bone marrow aplasia 76.28 12.70 90 71813 10091 42539341
Metastases to peritoneum 73.87 12.70 48 71855 2401 42547031
Focal nodular hyperplasia 73.52 12.70 22 71881 150 42549282
Asthma 69.36 12.70 11 71892 62303 42487129
Weight increased 68.95 12.70 49 71854 107934 42441498
Pneumonia 68.88 12.70 424 71479 421725 42127707
Hospitalisation 68.76 12.70 20 71883 74310 42475122
Fall 68.06 12.70 188 71715 234332 42315100
Conjunctivitis 68.06 12.70 96 71807 12843 42536589
Death 68.00 12.70 491 71412 470694 42078738
Gastrointestinal perforation 67.70 12.70 58 71845 4428 42545004
Enteritis 67.17 12.70 87 71816 10729 42538703
Ductal adenocarcinoma of pancreas 66.51 12.70 15 71888 24 42549408
Hyperammonaemic encephalopathy 66.36 12.70 47 71856 2711 42546721
Nipple swelling 66.17 12.70 25 71878 372 42549060
Injection site pain 64.79 12.70 10 71893 57788 42491644
Somnolence 64.65 12.70 86 71817 141019 42408413
Insomnia 64.01 12.70 63 71840 118190 42431242
Drug interaction 62.86 12.70 235 71668 266764 42282668
Neoplasm recurrence 62.28 12.70 45 71858 2679 42546753
Headache 61.49 12.70 203 71700 239166 42310266
Anxiety 59.86 12.70 67 71836 118493 42430939
Pneumatosis intestinalis 58.95 12.70 55 71848 4697 42544735
Influenza 57.01 12.70 17 71886 62158 42487274
Pulmonary embolism 56.92 12.70 371 71532 119241 42430191
Hypersensitivity 56.51 12.70 257 71646 72113 42477319
Dizziness 55.69 12.70 224 71679 249030 42300402
Dehydration 54.77 12.70 418 71485 141349 42408083
Drug clearance decreased 54.46 12.70 38 71865 2140 42547292
Subileus 54.11 12.70 46 71857 3475 42545957
Erythema 53.95 12.70 341 71562 108452 42440980
Tumour lysis syndrome 53.66 12.70 117 71786 22114 42527318
Mucosal toxicity 53.41 12.70 20 71883 290 42549142
Blood glucose increased 53.18 12.70 29 71874 73670 42475762
Anastomotic leak 53.08 12.70 26 71877 748 42548684
Recall phenomenon 52.39 12.70 24 71879 592 42548840
Asthenia 52.24 12.70 712 71191 280081 42269351
Device related infection 51.56 12.70 109 71794 20170 42529262
Ileus 51.15 12.70 105 71798 19034 42530398
Intentional overdose 51.10 12.70 12 71891 51444 42497988
Paraesthesia 50.19 12.70 251 71652 73208 42476224
Peripheral swelling 50.11 12.70 47 71856 90223 42459209
Metastases to lymph nodes 49.95 12.70 56 71847 5942 42543490
Myocardial infarction 49.59 12.70 83 71820 123926 42425506
Circulatory collapse 48.86 12.70 117 71786 23519 42525913
Small intestinal obstruction 48.45 12.70 96 71807 16965 42532467
Nipple pain 47.45 12.70 27 71876 1060 42548372
Portal venous gas 47.00 12.70 21 71882 488 42548944
Feeling abnormal 46.77 12.70 30 71873 69756 42479676
Intentional product misuse 46.67 12.70 23 71880 61877 42487555
Wheezing 46.67 12.70 17 71886 54764 42494668
Aggression 46.51 12.70 9 71894 44154 42505278
Suicidal ideation 46.33 12.70 12 71891 48149 42501283
Peripheral sensorimotor neuropathy 46.26 12.70 33 71870 1925 42547507
Anastomotic complication 46.02 12.70 20 71883 434 42548998
Depression 45.96 12.70 73 71830 111290 42438142
Ascites 45.53 12.70 203 71700 56475 42492957
Carbohydrate antigen 19-9 increased 44.45 12.70 17 71886 262 42549170
Febrile infection 44.23 12.70 37 71866 2734 42546698
Tumour necrosis 44.21 12.70 30 71873 1614 42547818
Subclavian vein thrombosis 44.18 12.70 25 71878 971 42548461
Cholangitis 44.17 12.70 71 71832 10656 42538776
Intentional product use issue 44.02 12.70 34 71869 71799 42477633
Hallucination 43.92 12.70 21 71882 57486 42491946
Bradycardia 43.47 12.70 48 71855 85436 42463996
Inappropriate schedule of product administration 43.35 12.70 59 71844 95843 42453589
Psoriasis 43.28 12.70 14 71889 48590 42500842
Sinusitis 43.23 12.70 13 71890 47279 42502153
Toxic leukoencephalopathy 42.74 12.70 22 71881 705 42548727
Hiccups 42.71 12.70 75 71828 12096 42537336
Stress 42.56 12.70 11 71892 44201 42505231
Foetal disorder 42.32 12.70 25 71878 1054 42548378
Intravascular haemolysis 42.07 12.70 20 71883 538 42548894
Colitis 41.40 12.70 172 71731 46400 42503032
Contusion 41.28 12.70 10 71893 41975 42507457
Arthralgia 41.20 12.70 192 71711 205046 42344386
Treatment noncompliance 41.13 12.70 7 71896 37665 42511767
Chronic obstructive pulmonary disease 41.12 12.70 28 71875 63086 42486346
Muscle spasms 40.87 12.70 51 71852 85993 42463439
Adverse drug reaction 40.78 12.70 7 71896 37427 42512005
Intestinal perforation 40.77 12.70 69 71834 10805 42538627
Pain in extremity 40.53 12.70 125 71778 150479 42398953
Type II hypersensitivity 38.84 12.70 11 71892 60 42549372
Administration site extravasation 38.51 12.70 21 71882 758 42548674
Plasma cell myeloma 38.49 12.70 16 71887 47562 42501870
Vascular access complication 38.25 12.70 17 71886 390 42549042
Stoma site pain 37.92 12.70 21 71882 782 42548650
Acute coronary syndrome 36.75 12.70 79 71824 14786 42534646
Monocyte chemotactic protein-1 increased 36.61 12.70 16 71887 352 42549080
Anaemia of malignant disease 36.59 12.70 18 71885 523 42548909
Proteus infection 36.51 12.70 25 71878 1365 42548067
Alpha tumour necrosis factor increased 36.40 12.70 16 71887 357 42549075
Mouth ulceration 36.39 12.70 79 71824 14884 42534548
Stoma site haemorrhage 36.39 12.70 23 71880 1096 42548336
Colon cancer metastatic 36.24 12.70 27 71876 1685 42547747
Nicotinic acid deficiency 36.07 12.70 12 71891 120 42549312
Electrocardiogram ST segment elevation 35.67 12.70 47 71856 5892 42543540
Cellulitis 35.44 12.70 31 71872 61554 42487878
Hepatic venous pressure gradient abnormal 35.33 12.70 9 71894 30 42549402
Neutropenia neonatal 35.26 12.70 21 71882 899 42548533
Anal haemorrhage 35.15 12.70 33 71870 2840 42546592
Ileal perforation 34.80 12.70 22 71881 1049 42548383
Productive cough 34.78 12.70 22 71881 51545 42497887
Sedation 34.78 12.70 5 71898 30470 42518962
Coronary artery disease 34.77 12.70 24 71879 53696 42495736
Hypoglycaemia 34.60 12.70 30 71873 59824 42489608
Memory impairment 34.46 12.70 21 71882 50201 42499231
Fluid retention 34.25 12.70 6 71897 31613 42517819
Trichomegaly 33.86 12.70 9 71894 37 42549395
Wrong technique in product usage process 33.44 12.70 15 71888 42620 42506812
Adenocarcinoma 33.39 12.70 28 71875 2076 42547356
Transdifferentiation of neoplasm 33.31 12.70 10 71893 69 42549363
Hyperbilirubinaemia 33.22 12.70 93 71810 20542 42528890
Colon cancer recurrent 33.06 12.70 11 71892 110 42549322
Cholinergic syndrome 32.93 12.70 18 71885 653 42548779
Interleukin level increased 32.88 12.70 20 71883 890 42548542
Epistaxis 32.81 12.70 209 71694 66617 42482815
Pelvic abscess 32.79 12.70 21 71882 1024 42548408
Troponin T increased 32.24 12.70 31 71872 2749 42546683
Drug ineffective for unapproved indication 32.10 12.70 19 71884 46144 42503288
Oesophagobronchial fistula 31.25 12.70 12 71891 187 42549245
Arthritis 31.15 12.70 16 71887 42049 42507383
Red blood cell sedimentation rate abnormal 30.56 12.70 35 71868 3801 42545631
Bone cyst 30.48 12.70 24 71879 1627 42547805
Unevaluable event 30.31 12.70 10 71893 34278 42515154
No adverse event 30.18 12.70 14 71889 39007 42510425
Joint ankylosis 30.15 12.70 24 71879 1653 42547779
Vena cava thrombosis 29.48 12.70 23 71880 1538 42547894
Blood creatine phosphokinase increased 29.46 12.70 23 71880 48315 42501117
Enterovesical fistula 29.33 12.70 19 71884 945 42548487
Proctalgia 29.27 12.70 47 71856 7046 42542386
Induration 29.24 12.70 20 71883 1090 42548342
Change of bowel habit 28.94 12.70 20 71883 1109 42548323
Necrotising fasciitis 28.90 12.70 37 71866 4509 42544923
Perforation 28.85 12.70 15 71888 491 42548941
Illness 28.66 12.70 4 71899 24926 42524506
Splenomegaly 28.60 12.70 78 71825 16969 42532463
Malignant ascites 28.26 12.70 16 71887 622 42548810
Venoocclusive liver disease 28.09 12.70 57 71846 10245 42539187
Peritonitis 28.08 12.70 82 71821 18551 42530881
Prothrombin level decreased 28.05 12.70 20 71883 1166 42548266
Jugular vein thrombosis 27.66 12.70 25 71878 2049 42547383
Anti-cyclic citrullinated peptide antibody positive 27.40 12.70 24 71879 1888 42547544
Portal vein thrombosis 27.32 12.70 36 71867 4513 42544919
Cerebrovascular accident 27.30 12.70 79 71824 97081 42452351
Device related thrombosis 26.66 12.70 21 71882 1424 42548008
Incorrect dose administered 26.65 12.70 30 71873 52944 42496488
Anaemia 26.47 12.70 639 71264 279639 42269793
Koebner phenomenon 26.31 12.70 8 71895 58 42549374
Large intestine perforation 26.29 12.70 53 71850 9483 42539949
Prostate cancer 26.26 12.70 22 71881 44621 42504811
Hand deformity 26.08 12.70 32 71871 3736 42545696
Sleep apnoea syndrome 25.97 12.70 3 71900 21605 42527827
Drug withdrawal syndrome 25.88 12.70 3 71900 21546 42527886
Pulmonary infarction 25.80 12.70 21 71882 1493 42547939
Overdose 25.79 12.70 91 71812 105173 42444259
Oral pain 25.65 12.70 62 71841 12534 42536898
Acne 25.51 12.70 65 71838 13579 42535853
Electrocardiogram QT prolonged 25.40 12.70 26 71877 47919 42501513
Clostridial infection 25.37 12.70 32 71871 3842 42545590
Loss of personal independence in daily activities 25.29 12.70 28 71875 49788 42499644
Influenza like illness 25.28 12.70 11 71892 31829 42517603
Evans syndrome 25.24 12.70 13 71890 417 42549015
Oesophageal carcinoma recurrent 25.22 12.70 7 71896 35 42549397
Migraine 25.08 12.70 6 71897 25408 42524024
Perihepatic abscess 25.07 12.70 9 71894 115 42549317
Angioedema 24.90 12.70 21 71882 42456 42506976
Contraindicated product administered 24.88 12.70 6 71897 25266 42524166
Rectal perforation 24.88 12.70 14 71889 538 42548894
Heart rate increased 24.83 12.70 32 71871 53223 42496209
Peritoneal neoplasm 24.75 12.70 7 71896 38 42549394
Injury 24.69 12.70 4 71899 22312 42527120
Rectal cancer metastatic 24.56 12.70 11 71892 257 42549175
Embolism 24.51 12.70 49 71854 8714 42540718
Skin injury 24.32 12.70 26 71877 2615 42546817
Astringent therapy 24.29 12.70 6 71897 17 42549415
Acute abdomen 24.16 12.70 23 71880 2014 42547418
Aplasia 24.10 12.70 35 71868 4808 42544624
Heart rate decreased 24.07 12.70 16 71887 36516 42512916
ECG signs of myocardial ischaemia 23.99 12.70 10 71893 195 42549237
Neutrophil count decreased 23.90 12.70 186 71717 63229 42486203
Nasopharyngitis 23.81 12.70 68 71835 83928 42465504
Hypoalbuminaemia 23.81 12.70 69 71834 15541 42533891
Cranial nerve disorder 23.77 12.70 14 71889 587 42548845
Small intestinal perforation 23.71 12.70 27 71876 2914 42546518
Enterocolitis 23.67 12.70 52 71851 9877 42539555
Hypokalaemia 23.61 12.70 204 71699 71517 42477915
Anastomotic fistula 23.04 12.70 8 71895 92 42549340
Liver function test abnormal 22.99 12.70 13 71890 32378 42517054
Bladder hypertrophy 22.94 12.70 15 71888 758 42548674
Gene mutation 22.84 12.70 21 71882 1760 42547672
Retinitis viral 22.67 12.70 9 71894 154 42549278
Disturbance in attention 22.66 12.70 11 71892 29855 42519577
Enterocutaneous fistula 22.57 12.70 18 71885 1243 42548189
Medication error 22.55 12.70 14 71889 33140 42516292
Toxic erythema of chemotherapy 22.51 12.70 9 71894 157 42549275
Fatigue 22.49 12.70 923 70980 434718 42114714
Product prescribing error 22.41 12.70 8 71895 26104 42523328
Nephrotic syndrome 22.32 12.70 47 71856 8671 42540761
Anal erythema 22.23 12.70 8 71895 103 42549329
Lung neoplasm malignant 22.18 12.70 3 71900 19144 42530288
Interventricular septum rupture 22.14 12.70 6 71897 27 42549405
Pancreatic carcinoma metastatic 22.10 12.70 27 71876 3139 42546293
Confusional state 21.99 12.70 179 71724 167418 42382014
Abdominal pain lower 21.98 12.70 57 71846 12035 42537397
Organic brain syndrome 21.94 12.70 11 71892 333 42549099
Oesophagitis 21.93 12.70 66 71837 15181 42534251
Cerebral vasoconstriction 21.89 12.70 10 71893 245 42549187
Pulmonary oedema 21.89 12.70 35 71868 53237 42496195
Multiple organ dysfunction syndrome 21.75 12.70 87 71816 96948 42452484
Nail disorder 21.59 12.70 23 71880 2304 42547128
Superior vena cava syndrome 21.53 12.70 14 71889 701 42548731
Condition aggravated 21.53 12.70 310 71593 260444 42288988
Injection site erythema 21.51 12.70 4 71899 20191 42529241
Ischiorectal hernia 21.46 12.70 5 71898 10 42549422
Chronic kidney disease 21.40 12.70 29 71874 47212 42502220
Rectosigmoid cancer 21.25 12.70 9 71894 183 42549249
Full blood count abnormal 21.19 12.70 12 71891 29864 42519568
Diaphragmatic operation 21.14 12.70 6 71897 33 42549399
Hepatic fibrosis 21.10 12.70 33 71870 4839 42544593
Visual impairment 21.05 12.70 25 71878 43088 42506344
Gastrooesophageal reflux disease 21.05 12.70 27 71876 44996 42504436
Oesophageal haemorrhage 20.77 12.70 18 71885 1396 42548036
Anal fissure 20.65 12.70 34 71869 5205 42544227
Accidental overdose 20.64 12.70 11 71892 28319 42521113
Metastasis 20.55 12.70 32 71871 4673 42544759
Hepatitis B surface antigen positive 20.36 12.70 8 71895 133 42549299
Pancreatic neuroendocrine tumour metastatic 20.31 12.70 8 71895 134 42549298
Mucocutaneous rash 20.30 12.70 6 71897 39 42549393
Hepatic lesion 20.24 12.70 31 71872 4463 42544969
Cholecystitis chronic 20.22 12.70 15 71888 930 42548502
Sepsis 20.18 12.70 459 71444 198875 42350557
Therapy non-responder 20.14 12.70 37 71866 53322 42496110
Jaundice 20.05 12.70 113 71790 34476 42514956
Renal disorder 20.04 12.70 12 71891 28968 42520464
Renal impairment 19.86 12.70 107 71796 110121 42439311
Dyspnoea 19.86 12.70 582 71321 442039 42107393
Venous thrombosis 19.84 12.70 29 71874 4006 42545426
Dysaesthesia 19.81 12.70 23 71880 2534 42546898
Agitation 19.79 12.70 50 71853 64264 42485168
Thrombotic thrombocytopenic purpura 19.67 12.70 28 71875 3776 42545656
Growth of eyelashes 19.60 12.70 7 71896 88 42549344
Hypertension 19.49 12.70 393 71510 166811 42382621
Nephrolithiasis 19.47 12.70 20 71883 36810 42512622
Perioral dermatitis 19.46 12.70 9 71894 227 42549205
International normalised ratio increased 19.46 12.70 32 71871 48136 42501296
Acute motor-sensory axonal neuropathy 19.38 12.70 8 71895 152 42549280
Colitis ulcerative 19.31 12.70 10 71893 26165 42523267
Pelvic fluid collection 19.14 12.70 9 71894 236 42549196
Catheter site thrombosis 18.96 12.70 8 71895 161 42549271
Posterior reversible encephalopathy syndrome 18.91 12.70 56 71847 12765 42536667
Electromyogram abnormal 18.90 12.70 6 71897 51 42549381
Sarcoidosis 18.89 12.70 27 71876 3655 42545777
Haemolytic anaemia 18.88 12.70 54 71849 12073 42537359
Pulmonary artery thrombosis 18.87 12.70 14 71889 868 42548564
Product administration error 18.77 12.70 4 71899 18339 42531093
Laboratory test interference 18.74 12.70 12 71891 585 42548847
Lymphopenia 18.66 12.70 79 71824 21484 42527948
Organising pneumonia 18.58 12.70 40 71863 7492 42541940
Pseudocirrhosis 18.54 12.70 5 71898 22 42549410
Hypervolaemia 18.34 12.70 8 71895 23117 42526315
Abnormal behaviour 18.23 12.70 11 71892 26440 42522992
Eyelash changes 18.18 12.70 5 71898 24 42549408
Varices oesophageal 18.12 12.70 29 71874 4336 42545096
Ocular toxicity 18.07 12.70 10 71893 372 42549060
Catheter site extravasation 18.02 12.70 8 71895 183 42549249
Radiation interaction 18.02 12.70 5 71898 25 42549407
Balance disorder 18.02 12.70 33 71870 47612 42501820
Toxicity to various agents 18.00 12.70 275 71628 228861 42320571
Liver abscess 17.92 12.70 31 71872 4939 42544493
Folliculitis 17.90 12.70 33 71870 5525 42543907
B-cell small lymphocytic lymphoma 17.86 12.70 8 71895 187 42549245
Blood pressure increased 17.79 12.70 100 71803 101828 42447604
Pneumoperitoneum 17.78 12.70 21 71882 2357 42547075
Peritoneal adhesions 17.73 12.70 7 71896 118 42549314
Visceral venous thrombosis 17.70 12.70 5 71898 27 42549405
Frequent bowel movements 17.64 12.70 7 71896 21400 42528032
Irritability 17.63 12.70 13 71890 28115 42521317
Deep vein thrombosis 17.61 12.70 203 71700 76754 42472678
Perineal disorder 17.60 12.70 6 71897 65 42549367
Colitis microscopic 17.60 12.70 24 71879 3109 42546323
Large intestinal obstruction 17.56 12.70 18 71885 1724 42547708
Emotional distress 17.55 12.70 3 71900 16090 42533342
Non-cirrhotic portal hypertension 17.52 12.70 10 71893 395 42549037
Gastrointestinal obstruction 17.51 12.70 15 71888 1145 42548287
Haematoma 17.50 12.70 13 71890 28010 42521422
Hepatectomy 17.46 12.70 7 71896 123 42549309
Swollen tongue 17.40 12.70 7 71896 21224 42528208
K-ras gene mutation 17.25 12.70 5 71898 30 42549402
Drug clearance increased 17.21 12.70 7 71896 128 42549304
Therapy interrupted 17.18 12.70 8 71895 22242 42527190
Tumour marker increased 17.18 12.70 13 71890 831 42548601
Intestinal strangulation 17.11 12.70 5 71898 31 42549401
Perforation bile duct 17.05 12.70 6 71897 72 42549360
Stomal varices 17.01 12.70 7 71896 132 42549300
Balanoposthitis 16.80 12.70 17 71886 1604 42547828
Peritoneal disorder 16.79 12.70 9 71894 314 42549118
Hepatic cancer recurrent 16.76 12.70 9 71894 315 42549117
Neurosarcoidosis 16.70 12.70 8 71895 219 42549213
Cardiac disorder 16.69 12.70 36 71867 48896 42500536
Urge incontinence 16.68 12.70 11 71892 564 42548868
Oesophageal irritation 16.62 12.70 6 71897 78 42549354
Colorectal cancer recurrent 16.62 12.70 6 71897 78 42549354
Performance status decreased 16.45 12.70 29 71874 4691 42544741
Pelvic inflammatory disease 16.28 12.70 4 71899 11 42549421
Urticaria 16.19 12.70 67 71836 73969 42475463
Seizure 16.15 12.70 128 71775 120433 42428999
Road traffic accident 16.13 12.70 6 71897 19087 42530345
Tinnitus 16.13 12.70 15 71888 28923 42520509
Portal shunt 16.13 12.70 5 71898 39 42549393
Obesity 16.02 12.70 4 71899 16455 42532977
Palpitations 16.01 12.70 39 71864 50758 42498674
Encephalopathy 16.00 12.70 122 71781 41211 42508221
Pain 15.95 12.70 304 71599 244544 42304888
Tremor 15.90 12.70 97 71806 96832 42452600
Product use issue 15.84 12.70 71 71832 76680 42472752
Haematopoietic stem cell mobilisation 15.83 12.70 9 71894 353 42549079
Mobility decreased 15.66 12.70 22 71881 35284 42514148
Cerebral haemorrhage 15.63 12.70 26 71877 38940 42510492
Cardiac arrest 15.62 12.70 114 71789 109206 42440226
Respiratory arrest 15.53 12.70 15 71888 28409 42521023
Pruritus allergic 15.51 12.70 9 71894 367 42549065
Cardiac failure 15.48 12.70 111 71792 106745 42442687
Pancreatic carcinoma recurrent 15.43 12.70 6 71897 97 42549335
Rectal adenocarcinoma 15.39 12.70 13 71890 973 42548459
Temperature difference of extremities 15.34 12.70 4 71899 15 42549417
Klebsiella infection 15.31 12.70 48 71855 11284 42538148
Flushing 15.30 12.70 111 71792 36917 42512515
Brief psychotic disorder with marked stressors 15.27 12.70 8 71895 266 42549166
Vocal cord paralysis 15.16 12.70 14 71889 1180 42548252
Osteolysis 15.16 12.70 24 71879 3556 42545876
Swelling 15.14 12.70 45 71858 54840 42494592
Paraesthesia mucosal 15.14 12.70 4 71899 16 42549416
Toxoplasmosis 15.12 12.70 16 71887 1591 42547841
Neck pain 15.09 12.70 17 71886 29997 42519435
Malaise 14.88 12.70 260 71643 211896 42337536
Diffuse alveolar damage 14.78 12.70 20 71883 2572 42546860
Pelvic infection 14.77 12.70 5 71898 53 42549379
Blood glucose decreased 14.75 12.70 3 71900 14216 42535216
Adverse event 14.72 12.70 11 71892 23629 42525803
Rash maculo-papular 14.68 12.70 111 71792 37392 42512040
Bronchiectasis 14.67 12.70 6 71897 18013 42531419
Herpes zoster 14.63 12.70 27 71876 38850 42510582
Pneumonia aspiration 14.59 12.70 40 71863 50038 42499394
Cachexia 14.52 12.70 38 71865 8066 42541366
Bacteriuria 14.52 12.70 8 71895 295 42549137
Diabetic ketoacidosis 14.46 12.70 10 71893 22357 42527075
Fingerprint loss 14.44 12.70 5 71898 57 42549375
Onychoclasis 14.43 12.70 20 71883 2632 42546800
Limbic encephalitis 14.35 12.70 9 71894 423 42549009
Dyskinesia 14.34 12.70 13 71890 25377 42524055
Blood bilirubin increased 14.33 12.70 121 71782 42131 42507301
Proctitis 14.31 12.70 21 71882 2912 42546520
Xerosis 14.14 12.70 12 71891 904 42548528
Bacterial colitis 14.06 12.70 5 71898 62 42549370
Skin fissures 14.02 12.70 42 71861 9634 42539798
Hypoacusis 14.02 12.70 7 71896 18695 42530737
Bone erosion 14.00 12.70 26 71877 4377 42545055
Guillain-Barre syndrome 13.99 12.70 35 71868 7228 42542204
Cardiac pacemaker evaluation 13.99 12.70 6 71897 126 42549306
Laryngospasm 13.95 12.70 17 71886 1971 42547461
Intestinal transit time abnormal 13.95 12.70 4 71899 23 42549409
Gastrointestinal anastomotic leak 13.93 12.70 10 71893 589 42548843
Iatrogenic infection 13.92 12.70 5 71898 64 42549368
Pneumatosis 13.92 12.70 10 71893 590 42548842
Tracheal inflammation 13.85 12.70 5 71898 65 42549367
Liver operation 13.80 12.70 4 71899 24 42549408
Therapeutic response shortened 13.78 12.70 3 71900 13551 42535881
Rectal stenosis 13.69 12.70 7 71896 221 42549211
Pulmonary alveolar haemorrhage 13.67 12.70 4 71899 14812 42534620
Appendicolith 13.63 12.70 3 71900 13453 42535979
Miosis 13.62 12.70 3 71900 13443 42535989
Haemorrhage intracranial 13.55 12.70 6 71897 17186 42532246
Pleural fistula 13.53 12.70 4 71899 26 42549406
Candida infection 13.47 12.70 72 71831 21538 42527894
Low birth weight baby 13.30 12.70 42 71861 9913 42539519
Eczema impetiginous 13.28 12.70 4 71899 28 42549404
Crystal nephropathy 13.22 12.70 10 71893 639 42548793
Retroperitoneal abscess 13.21 12.70 8 71895 353 42549079
Restlessness 13.20 12.70 18 71885 29231 42520201
Pulmonary congestion 13.20 12.70 5 71898 15725 42533707
Ventricular tachycardia 13.17 12.70 19 71884 30141 42519291
Psychotic disorder 13.16 12.70 18 71885 29190 42520242
Neuropathic muscular atrophy 13.15 12.70 4 71899 29 42549403
Ischaemic stroke 13.13 12.70 73 71830 22160 42527272
Prostatic calcification 13.10 12.70 6 71897 148 42549284
Nasal septum perforation 13.09 12.70 7 71896 243 42549189
Duodenal perforation 13.08 12.70 15 71888 1631 42547801
Proctectomy 13.06 12.70 6 71897 149 42549283
Abdominal sepsis 13.02 12.70 13 71890 1207 42548225
Gallbladder polyp 13.01 12.70 9 71894 500 42548932
Hyperkalaemia 12.94 12.70 81 71822 80377 42469055
Optic disc drusen 12.87 12.70 3 71900 6 42549426
Hypocalcaemia 12.78 12.70 91 71812 30082 42519350
Therapeutic product effect incomplete 12.77 12.70 179 71724 70760 42478672
Tubulointerstitial nephritis 12.70 12.70 21 71882 31527 42517905

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 2247.42 10.78 2417 121668 372203 110093011
Neuropathy peripheral 1697.52 10.78 1488 122597 177789 110287425
Disease progression 1147.07 10.78 1390 122695 242644 110222570
Skin toxicity 953.86 10.78 393 123692 11390 110453824
Diarrhoea 897.51 10.78 3055 121030 1136450 109328764
Mucosal inflammation 888.71 10.78 788 123297 95353 110369861
Neurotoxicity 859.39 10.78 555 123530 41652 110423562
Thrombocytopenia 851.28 10.78 1455 122630 347430 110117784
Dermatitis acneiform 668.73 10.78 313 123772 12382 110452832
Febrile neutropenia 548.90 10.78 1142 122943 315625 110149589
Polyneuropathy 499.18 10.78 357 123728 31655 110433559
Neoplasm progression 444.74 10.78 450 123635 64145 110401069
Arteriospasm coronary 423.28 10.78 206 123879 8894 110456320
Leukopenia 416.52 10.78 661 123424 148130 110317084
Palmar-plantar erythrodysaesthesia syndrome 410.49 10.78 352 123733 40673 110424541
Metastases to liver 404.63 10.78 328 123757 35058 110430156
Haematotoxicity 323.81 10.78 233 123852 20849 110444365
Bone marrow failure 278.35 10.78 334 123751 57514 110407700
Gastrointestinal toxicity 270.65 10.78 164 123921 10984 110454230
Proteinuria 261.27 10.78 271 123814 39747 110425467
Myelosuppression 258.22 10.78 415 123670 93925 110371289
Completed suicide 247.27 10.78 5 124080 242376 110222838
Rash pustular 232.61 10.78 157 123928 12672 110452542
Peripheral sensory neuropathy 230.55 10.78 173 123912 16507 110448707
Nausea 230.36 10.78 2253 121832 1233437 109231777
Malignant neoplasm progression 229.97 10.78 565 123520 174002 110291212
Metastases to lung 222.80 10.78 194 123891 22869 110442345
Therapy partial responder 220.69 10.78 239 123846 36822 110428392
Secondary immunodeficiency 217.91 10.78 106 123979 4570 110460644
Paronychia 216.34 10.78 142 123943 10939 110454275
Pulmonary embolism 194.86 10.78 606 123479 213868 110251346
Enteritis 192.88 10.78 165 123920 18991 110446223
Vomiting 188.56 10.78 1699 122386 908976 109556238
Portal hypertension 186.68 10.78 118 123967 8519 110456695
Stomatitis 186.14 10.78 696 123389 269546 110195668
Pemphigus 184.33 10.78 15 124070 214555 110250659
Peripheral swelling 181.06 10.78 115 123970 403919 110061295
Pyrexia 180.93 10.78 1666 122419 896599 109568615
Swelling 180.47 10.78 84 124001 350957 110114257
Product dose omission issue 179.87 10.78 68 124017 321714 110143500
Colorectal cancer metastatic 174.15 10.78 66 124019 1523 110463691
Cardiotoxicity 171.18 10.78 146 123939 16735 110448479
Anaemia 169.60 10.78 1122 122963 545964 109919250
Systemic lupus erythematosus 169.00 10.78 39 124046 254299 110210915
Wheezing 167.89 10.78 40 124045 255190 110210024
Chills 167.13 10.78 532 123553 190048 110275166
Glossodynia 166.83 10.78 25 124060 221979 110243235
Hypomagnesaemia 163.02 10.78 264 123821 60106 110405108
Leukoencephalopathy 160.69 10.78 110 123975 9085 110456129
Focal nodular hyperplasia 153.25 10.78 52 124033 861 110464353
Interstitial lung disease 151.68 10.78 420 123665 138914 110326300
Carcinoembryonic antigen increased 149.85 10.78 70 124015 2754 110462460
Drug clearance decreased 149.85 10.78 79 124006 4043 110461171
Hyperammonaemia 143.82 10.78 121 123964 13611 110451603
Weight increased 142.92 10.78 156 123929 419488 110045726
Synovitis 138.67 10.78 67 124018 274025 110191189
Insomnia 137.86 10.78 121 123964 360469 110104745
Non-cirrhotic portal hypertension 135.45 10.78 45 124040 696 110464518
Abdominal pain 135.42 10.78 1012 123073 511977 109953237
Injury 135.41 10.78 19 124066 177246 110287968
Hyperammonaemic encephalopathy 134.64 10.78 81 124004 5353 110459861
Intestinal obstruction 133.27 10.78 225 123860 53002 110412212
Joint swelling 132.50 10.78 182 123903 442663 110022551
Arthropathy 131.29 10.78 80 124005 287442 110177772
Asthma 129.98 10.78 59 124026 250232 110214982
Mobility decreased 129.63 10.78 52 124033 237370 110227844
Helicobacter infection 128.83 10.78 24 124061 181853 110283361
Wound 128.56 10.78 51 124034 234386 110230828
Irritable bowel syndrome 124.50 10.78 18 124067 164197 110301017
Tumour lysis syndrome 124.45 10.78 163 123922 30638 110434576
Type 2 diabetes mellitus 124.24 10.78 24 124061 177208 110288006
Drug abuse 122.32 10.78 25 124060 177386 110287828
Posterior reversible encephalopathy syndrome 121.29 10.78 169 123916 33692 110431522
Duodenal ulcer perforation 120.54 10.78 26 124059 177674 110287540
Pancytopenia 120.24 10.78 510 123575 209103 110256111
Fall 120.06 10.78 317 123768 603165 109862049
Rheumatoid factor positive 116.46 10.78 8 124077 131632 110333582
Blister 115.89 10.78 55 124030 227321 110237893
Pericarditis 114.79 10.78 51 124034 219063 110246151
Memory impairment 112.74 10.78 40 124045 196904 110268310
Pneumatosis intestinalis 112.43 10.78 86 123999 8443 110456771
Device related infection 112.42 10.78 177 123908 39342 110425872
Mycobacterium chelonae infection 112.24 10.78 59 124026 3001 110462213
Dehydration 111.13 10.78 612 123473 278899 110186315
Ascites 110.27 10.78 289 123796 92519 110372695
Venoocclusive liver disease 110.23 10.78 109 123976 15098 110450116
Gastrointestinal perforation 106.76 10.78 79 124006 7377 110457837
Maternal exposure during pregnancy 105.53 10.78 79 124006 254804 110210410
Muscle injury 103.17 10.78 17 124068 140790 110324424
Febrile bone marrow aplasia 102.86 10.78 112 123973 17353 110447861
Depression 102.54 10.78 123 123962 317212 110148002
Intestinal perforation 102.48 10.78 122 123963 20822 110444392
Intentional overdose 101.67 10.78 14 124071 132487 110332727
Blood cholesterol increased 101.63 10.78 40 124045 184745 110280469
Lower respiratory tract infection 101.10 10.78 75 124010 243031 110222183
Hepatic enzyme increased 100.93 10.78 127 123958 320765 110144449
Hand deformity 100.85 10.78 60 124025 218446 110246768
Anti-cyclic citrullinated peptide antibody positive 100.74 10.78 39 124046 181945 110283269
Sepsis 99.81 10.78 669 123416 326677 110138537
Splenomegaly 97.97 10.78 129 123956 24369 110440845
Sinusitis 96.92 10.78 114 123971 296574 110168640
Ileus 96.37 10.78 144 123941 30585 110434629
Pain 94.82 10.78 655 123430 954300 109510914
Epistaxis 94.04 10.78 341 123744 130031 110335183
Loss of employment 93.76 10.78 54 124031 3290 110461924
Discomfort 93.54 10.78 63 124022 214644 110250570
Cholangitis 93.16 10.78 103 123982 16232 110448982
Migraine 93.02 10.78 38 124047 171614 110293600
Fibromyalgia 90.74 10.78 39 124046 170870 110294344
Arthralgia 90.68 10.78 509 123576 779123 109686091
Dizziness 88.90 10.78 442 123643 697751 109767463
Intentional product use issue 86.75 10.78 90 123995 247816 110217398
Headache 84.25 10.78 612 123473 881765 109583449
Bacterial infection 84.22 10.78 170 123915 45866 110419348
Metastases to peritoneum 83.85 10.78 61 124024 5549 110459665
Contraindicated product administered 83.68 10.78 93 123992 248174 110217040
Mucosal toxicity 83.47 10.78 31 124054 675 110464539
Impaired healing 82.67 10.78 60 124025 196657 110268557
General physical health deterioration 82.32 10.78 783 123302 424512 110040702
Pain in extremity 81.60 10.78 277 123808 486841 109978373
Sleep disorder due to general medical condition, insomnia type 81.43 10.78 11 124074 105632 110359582
Rheumatic fever 80.99 10.78 19 124066 122560 110342654
Subileus 80.69 10.78 63 124022 6374 110458840
Trichomegaly 80.67 10.78 21 124064 128 110465086
Injection site pain 80.50 10.78 50 124035 177872 110287342
Anastomotic leak 79.53 10.78 36 124049 1316 110463898
Contusion 79.10 10.78 87 123998 233274 110231940
Nasopharyngitis 78.46 10.78 207 123878 394154 110071060
Neutrophil count decreased 77.83 10.78 305 123780 120636 110344578
Gene mutation 77.00 10.78 48 124037 3381 110461833
Rhabdomyolysis 76.94 10.78 20 124065 120381 110344833
Colitis 76.65 10.78 271 123814 102052 110363162
Nipple swelling 76.14 10.78 25 124060 372 110464842
Obesity 76.02 10.78 17 124068 113334 110351880
Anxiety 75.81 10.78 172 123913 344906 110120308
Rectal tenesmus 75.61 10.78 41 124044 2221 110462993
Gastrooesophageal reflux disease 75.49 10.78 55 124030 179921 110285293
Sleep disorder 75.45 10.78 67 124018 198577 110266637
Skin reaction 74.93 10.78 105 123980 21039 110444175
Intentional product misuse 74.35 10.78 28 124057 132876 110332338
Administration site extravasation 74.03 10.78 37 124048 1692 110463522
Pseudomonal sepsis 73.41 10.78 69 124016 8977 110456237
Human bocavirus infection 72.63 10.78 32 124053 1096 110464118
Decreased appetite 72.24 10.78 834 123251 475012 109990202
Diffuse alveolar damage 72.11 10.78 49 124036 3998 110461216
Folliculitis 70.62 10.78 51 124034 167602 110297612
Hospitalisation 70.27 10.78 36 124049 142457 110322757
Neoplasm recurrence 69.50 10.78 53 124032 5179 110460035
Breast cancer stage III 69.42 10.78 5 124080 79112 110386102
Abdominal discomfort 69.37 10.78 219 123866 393639 110071575
Joint range of motion decreased 69.28 10.78 25 124060 121807 110343407
Acute kidney injury 68.73 10.78 1047 123038 634383 109830831
Parainfluenzae virus infection 68.03 10.78 59 124026 6915 110458299
Tumour necrosis 67.40 10.78 39 124046 2397 110462817
Embolism 67.04 10.78 87 123998 16202 110449012
Nicotinic acid deficiency 66.76 10.78 20 124065 216 110464998
Hypokalaemia 66.22 10.78 390 123695 182058 110283156
Myalgia 65.83 10.78 92 123993 222289 110242925
Encephalopathy 65.35 10.78 220 123865 80835 110384379
Asthenia 65.06 10.78 1110 122975 687889 109777325
Psoriatic arthropathy 64.89 10.78 75 124010 196686 110268528
Exposure during pregnancy 64.15 10.78 56 124029 167368 110297846
Facet joint syndrome 63.98 10.78 15 124070 96813 110368401
Swollen joint count increased 63.80 10.78 9 124076 83652 110381562
Hyperbilirubinaemia 63.08 10.78 119 123966 30552 110434662
Deep vein thrombosis 62.89 10.78 317 123768 139570 110325644
Dysarthria 62.32 10.78 222 123863 83899 110381315
Abscess bacterial 61.69 10.78 27 124058 910 110464304
Vena cava thrombosis 61.53 10.78 42 124043 3452 110461762
Small intestinal obstruction 60.17 10.78 120 123965 32093 110433121
Fluid retention 59.62 10.78 16 124069 94291 110370923
Gait inability 59.40 10.78 40 124045 136336 110328878
Peripheral sensorimotor neuropathy 59.22 10.78 43 124042 3900 110461314
Urticaria 58.48 10.78 174 123911 318683 110146531
Psoriasis 58.42 10.78 43 124042 139950 110325264
Grip strength decreased 58.02 10.78 10 124075 80164 110385050
Septic shock 56.69 10.78 336 123749 157192 110308022
Confusional state 56.58 10.78 302 123783 468378 109996836
Hypercholesterolaemia 56.33 10.78 16 124069 90821 110374393
Cholinergic syndrome 55.55 10.78 28 124057 1304 110463910
Large intestinal obstruction 55.04 10.78 41 124044 3867 110461347
Adverse drug reaction 54.59 10.78 25 124060 105534 110359680
Peritonitis 54.47 10.78 116 123969 32491 110432723
Sedation 54.32 10.78 7 124078 69676 110395538
Recall phenomenon 54.31 10.78 28 124057 1368 110463846
Drug ineffective 53.65 10.78 1299 122786 1519241 108945973
Hiccups 53.38 10.78 69 124016 12800 110452414
Arthritis 53.00 10.78 66 124019 167520 110297694
Metastases to lymph nodes 52.31 10.78 74 124011 14958 110450256
Mouth ulceration 52.24 10.78 145 123940 47993 110417221
Suicidal ideation 52.19 10.78 20 124065 93917 110371297
Haemolytic anaemia 51.78 10.78 88 123997 20832 110444382
C-reactive protein abnormal 51.37 10.78 42 124043 129653 110335561
Somnolence 51.23 10.78 167 123918 297282 110167932
Drug hypersensitivity 50.79 10.78 300 123785 453790 110011424
Steatohepatitis 50.64 10.78 26 124059 1259 110463955
Enterobacter infection 50.40 10.78 46 124039 5765 110459449
Nipple pain 50.27 10.78 25 124060 1131 110464083
Lip dry 49.77 10.78 25 124060 100058 110365156
Hypoalbuminaemia 49.47 10.78 104 123981 28870 110436344
Pelvic abscess 49.45 10.78 33 124052 2613 110462601
Pneumonia 49.36 10.78 690 123395 876024 109589190
Acute coronary syndrome 49.19 10.78 91 123994 23021 110442193
Venous thrombosis 49.14 10.78 54 124031 8451 110456763
Adverse event 48.63 10.78 31 124054 108778 110356436
Loss of personal independence in daily activities 48.58 10.78 58 124027 149962 110315252
Conjunctivitis 48.34 10.78 113 123972 33679 110431535
Treatment failure 48.19 10.78 155 123930 277079 110188135
Bursitis 47.92 10.78 45 124040 129873 110335341
Toxic leukoencephalopathy 47.72 10.78 27 124058 1590 110463624
Electrocardiogram ST segment elevation 47.54 10.78 55 124030 9105 110456109
Nodular regenerative hyperplasia 47.50 10.78 27 124058 1604 110463610
Human herpesvirus 6 infection 47.38 10.78 47 124038 6534 110458680
Metastases to meninges 47.25 10.78 42 124043 5086 110460128
Product quality issue 47.22 10.78 14 124071 77285 110387929
Medication error 47.11 10.78 30 124055 105336 110359878
Hepatic steatosis 47.10 10.78 141 123944 48690 110416524
Crystal nephropathy 46.85 10.78 28 124057 1828 110463386
Ocular toxicity 46.82 10.78 25 124060 1313 110463901
Superior vena cava syndrome 46.77 10.78 25 124060 1316 110463898
Portal vein thrombosis 46.42 10.78 48 124037 7010 110458204
Colon cancer metastatic 46.28 10.78 31 124054 2470 110462744
Haemolytic uraemic syndrome 46.27 10.78 41 124044 4944 110460270
Second primary malignancy 46.04 10.78 77 124008 17991 110447223
Jugular vein thrombosis 45.75 10.78 42 124043 5303 110459911
Cystitis bacterial 45.51 10.78 24 124061 1229 110463985
Norovirus test positive 45.23 10.78 22 124063 948 110464266
Subclavian vein thrombosis 45.09 10.78 32 124053 2800 110462414
Anastomotic complication 44.80 10.78 19 124066 592 110464622
Electrocardiogram QT prolonged 44.78 10.78 34 124051 108926 110356288
Wrong technique in product usage process 44.68 10.78 21 124064 87327 110377887
Lymphopenia 44.58 10.78 122 123963 40048 110425166
Growth of eyelashes 44.30 10.78 14 124071 183 110465031
Muscle spasms 43.96 10.78 162 123923 277995 110187219
Hallucination 43.84 10.78 30 124055 101402 110363812
Peripheral venous disease 43.37 10.78 20 124065 84097 110381117
Anastomotic fistula 43.34 10.78 13 124072 141 110465073
Type II hypersensitivity 43.05 10.78 12 124073 98 110465116
Knee arthroplasty 43.03 10.78 10 124075 64938 110400276
Monocyte chemotactic protein-1 increased 42.93 10.78 16 124069 352 110464862
Oedema 42.65 10.78 109 123976 209867 110255347
Stoma site haemorrhage 42.64 10.78 29 124056 2369 110462845
Large intestine perforation 42.55 10.78 71 124014 16558 110448656
Erythema 42.47 10.78 507 123578 290940 110174274
Ill-defined disorder 42.43 10.78 69 124016 156784 110308430
Musculoskeletal stiffness 42.27 10.78 166 123919 279656 110185558
Aplasia 42.09 10.78 48 124037 7825 110457389
Rash maculo-papular 42.05 10.78 180 123905 74042 110391172
Metastasis 41.84 10.78 49 124036 8218 110456996
Clostridium difficile colitis 41.84 10.78 126 123959 43652 110421562
Lymphoid tissue hypoplasia 41.72 10.78 25 124060 1640 110463574
Joint ankylosis 41.58 10.78 29 124056 2468 110462746
Drug dependence 41.57 10.78 4 124081 50016 110415198
Treatment noncompliance 41.45 10.78 15 124070 72975 110392239
Thymus hypoplasia 41.42 10.78 25 124060 1662 110463552
Prescribed underdose 41.31 10.78 11 124074 65163 110400051
Hepatocellular injury 41.30 10.78 138 123947 50504 110414710
Chronic obstructive pulmonary disease 41.22 10.78 37 124048 109121 110356093
Alpha tumour necrosis factor increased 41.17 10.78 16 124069 396 110464818
Neutropenic colitis 41.14 10.78 48 124037 8017 110457197
Night sweats 41.08 10.78 54 124031 133929 110331285
Influenza 40.70 10.78 80 124005 169021 110296193
ECG signs of myocardial ischaemia 40.58 10.78 16 124069 412 110464802
Varices oesophageal 40.29 10.78 45 124040 7170 110458044
Cytokine release syndrome 40.22 10.78 171 123914 70135 110395079
Colon cancer recurrent 40.19 10.78 12 124073 128 110465086
Carbohydrate antigen 19-9 increased 39.81 10.78 17 124068 539 110464675
Feeling abnormal 39.71 10.78 90 123995 180621 110284593
Hypertension 39.45 10.78 797 123288 509287 109955927
Productive cough 39.40 10.78 42 124043 114263 110350951
Hepatic lesion 39.14 10.78 48 124037 8445 110456769
Sciatica 39.04 10.78 28 124057 92371 110372843
Hypersensitivity vasculitis 38.28 10.78 43 124042 6894 110458320
Febrile infection 38.17 10.78 35 124050 4413 110460801
Klebsiella infection 37.92 10.78 75 124010 19934 110445280
Jaundice 37.78 10.78 149 123936 59087 110406127
Nasal septum perforation 37.30 10.78 19 124066 905 110464309
Stress 37.11 10.78 38 124047 105310 110359904
Blood glucose increased 37.06 10.78 57 124028 132439 110332775
Enterovesical fistula 36.88 10.78 22 124063 1431 110463783
Anal haemorrhage 36.83 10.78 36 124049 4916 110460298
Laryngospasm 36.72 10.78 35 124050 4633 110460581
Prescribed overdose 36.41 10.78 27 124058 87554 110377660
Injection site reaction 36.33 10.78 28 124057 89042 110376172
Bradycardia 36.21 10.78 75 124010 155442 110309772
Hip arthroplasty 36.18 10.78 9 124076 55804 110409410
Illness 35.92 10.78 24 124061 82147 110383067
No adverse event 35.89 10.78 19 124066 73820 110391394
Subretinal haematoma 35.59 10.78 9 124076 48 110465166
Skin injury 35.47 10.78 32 124053 3950 110461264
Osteoarthritis 35.41 10.78 97 123988 182526 110282688
Adenocarcinoma of colon 35.36 10.78 39 124046 6129 110459085
Nephrotic syndrome 35.32 10.78 59 124026 13772 110451442
Frequent bowel movements 35.25 10.78 18 124067 71372 110393842
Rectal perforation 35.23 10.78 19 124066 1018 110464196
Dislocation of vertebra 35.04 10.78 4 124081 43717 110421497
Stomal varices 34.72 10.78 11 124074 145 110465069
Oesophageal candidiasis 34.67 10.78 53 124032 11481 110453733
Lupus-like syndrome 34.60 10.78 3 124082 40789 110424425
Proctalgia 34.57 10.78 57 124028 13165 110452049
Thrombocytopenic purpura 34.37 10.78 28 124057 3011 110462203
Condition aggravated 34.32 10.78 599 123486 734237 109730977
Proteus infection 33.99 10.78 27 124058 2801 110462413
Transdifferentiation of neoplasm 33.98 10.78 10 124075 101 110465113
Portal venous gas 33.96 10.78 15 124070 517 110464697
Acute abdomen 33.93 10.78 29 124056 3332 110461882
Hepatic failure 33.91 10.78 160 123925 68579 110396635
Oesophageal atresia 33.72 10.78 10 124075 104 110465110
Enterocolitis 33.50 10.78 69 124016 18880 110446334
Disease recurrence 33.35 10.78 146 123939 60638 110404576
K-ras gene mutation 33.26 10.78 9 124076 65 110465149
Overdose 33.23 10.78 142 123943 233652 110231562
Road traffic accident 33.22 10.78 43 124042 107355 110357859
Leukoerythroblastosis 33.07 10.78 13 124072 332 110464882
Immune thrombocytopenia 33.03 10.78 76 124009 22418 110442796
Small intestinal perforation 32.90 10.78 32 124053 4344 110460870
Agranulocytosis 32.87 10.78 147 123938 61613 110403601
Pneumonitis 32.69 10.78 171 123914 76360 110388854
Intravascular haemolysis 32.63 10.78 18 124067 1009 110464205
Pelvic fluid collection 32.53 10.78 18 124067 1015 110464199
Gastrointestinal stoma complication 32.43 10.78 28 124057 3261 110461953
Cytomegalovirus chorioretinitis 32.39 10.78 40 124045 7088 110458126
Oesophagobronchial fistula 32.28 10.78 12 124073 262 110464952
Encapsulating peritoneal sclerosis 32.22 10.78 17 124068 871 110464343
Enterocutaneous fistula 31.89 10.78 24 124061 2299 110462915
Balance disorder 31.78 10.78 51 124034 116509 110348705
Gastrointestinal anastomotic leak 31.63 10.78 16 124069 751 110464463
Adenocarcinoma 31.62 10.78 31 124054 4249 110460965
Transaminases increased 31.60 10.78 148 123937 63242 110401972
Emotional distress 31.57 10.78 6 124079 44841 110420373
Gait disturbance 31.50 10.78 183 123902 278025 110187189
Organising pneumonia 31.47 10.78 57 124028 14186 110451028
Troponin T increased 31.46 10.78 31 124054 4275 110460939
Hypocalcaemia 31.41 10.78 151 123934 65215 110399999
Liver abscess 31.33 10.78 41 124044 7698 110457516
Portal shunt 31.03 10.78 9 124076 86 110465128
Venous pressure jugular decreased 31.03 10.78 9 124076 86 110465128
Injection site erythema 30.92 10.78 36 124049 94140 110371074
Myocardial infarction 30.92 10.78 111 123974 191972 110273242
Stress cardiomyopathy 30.87 10.78 60 124025 15746 110449468
Obstructive airways disorder 30.78 10.78 7 124078 46142 110419072
Colitis ulcerative 30.70 10.78 25 124060 77338 110387876
Product use issue 30.69 10.78 214 123871 311481 110153733
Inappropriate schedule of product administration 30.62 10.78 121 123964 203516 110261698
Hypoaesthesia 30.32 10.78 217 123868 314006 110151208
Visual impairment 30.31 10.78 66 124019 134362 110330852
Therapeutic product effect decreased 30.24 10.78 156 123929 244160 110221054
Ileal perforation 29.94 10.78 19 124066 1381 110463833
Interleukin level increased 29.77 10.78 20 124065 1601 110463613
Pharyngeal dyskinesia 29.53 10.78 8 124077 58 110465156
Pruritus 29.45 10.78 467 123618 581093 109884121
Live birth 29.43 10.78 21 124064 69463 110395751
Cystitis radiation 29.30 10.78 11 124074 247 110464967
X-ray abnormal 29.30 10.78 4 124081 38113 110427101
Device related thrombosis 29.24 10.78 27 124058 3435 110461779
Drug withdrawal syndrome 29.23 10.78 4 124081 38050 110427164
T-cell lymphoma refractory 29.03 10.78 9 124076 110 110465104
Drug ineffective for unapproved indication 28.99 10.78 44 124041 102794 110362420
Amnesia 28.85 10.78 46 124039 105362 110359852
Onychomadesis 28.39 10.78 8 124077 45655 110419559
Back injury 28.20 10.78 9 124076 47390 110417824
Gastrointestinal necrosis 28.16 10.78 36 124049 6604 110458610
Pregnancy 28.15 10.78 11 124074 51056 110414158
Neck pain 28.14 10.78 60 124025 123070 110342144
Chemotherapeutic drug level above therapeutic 27.98 10.78 9 124076 125 110465089
Metastases to ovary 27.88 10.78 12 124073 388 110464826
Oesophagitis 27.77 10.78 83 124002 28632 110436582
Flushing 27.74 10.78 207 123878 104529 110360685
Anaemia of malignant disease 27.70 10.78 16 124069 980 110464234
Laboratory test interference 27.67 10.78 18 124067 1365 110463849
Koebner phenomenon 27.53 10.78 8 124077 77 110465137
Lupus vulgaris 27.41 10.78 3 124082 33880 110431334
Necrotising fasciitis 27.35 10.78 38 124047 7553 110457661
Performance status decreased 27.12 10.78 37 124048 7229 110457985
Pancreatic neuroendocrine tumour metastatic 26.87 10.78 10 124075 219 110464995
Aortic thrombosis 26.57 10.78 21 124064 2162 110463052
Sinus disorder 26.21 10.78 3 124082 32725 110432489
Paraesthesia 26.19 10.78 446 123639 276075 110189139
Cholestasis 26.08 10.78 142 123943 64376 110400838
Teratogenicity 26.06 10.78 10 124075 239 110464975
Pneumoperitoneum 26.03 10.78 27 124058 3957 110461257
Laryngeal dyspnoea 25.87 10.78 11 124074 345 110464869
Bacteraemia 25.73 10.78 105 123980 42285 110422929
Influenza like illness 25.73 10.78 37 124048 88375 110376839
Factor VII deficiency 25.64 10.78 8 124077 100 110465114
Perihepatic abscess 25.52 10.78 9 124076 168 110465046
Prothrombin level decreased 25.52 10.78 19 124066 1791 110463423
Viraemia 25.37 10.78 27 124058 4075 110461139
Laryngitis 25.33 10.78 8 124077 42403 110422811
Joint dislocation 25.32 10.78 4 124081 34186 110431028
Neuromyotonia 25.22 10.78 8 124077 106 110465108
Cardiac failure congestive 25.14 10.78 86 123999 150914 110314300
Joint stiffness 25.14 10.78 23 124062 67220 110397994
Osteolysis 25.11 10.78 31 124054 5492 110459722
Unevaluable event 24.95 10.78 18 124067 59209 110406005
Induration 24.91 10.78 21 124064 2368 110462846
Clostridial infection 24.91 10.78 33 124052 6269 110458945
Muscle spasticity 24.87 10.78 5 124080 35910 110429304
Respiratory disorder 24.85 10.78 26 124059 71356 110393858
Mixed adenoneuroendocrine carcinoma 24.75 10.78 6 124079 26 110465188
Venous thrombosis limb 24.66 10.78 30 124055 5235 110459979
Bacteriuria 24.65 10.78 17 124068 1421 110463793
Cytopenia 24.50 10.78 82 124003 30034 110435180
Astringent therapy 24.39 10.78 6 124079 28 110465186
Foot deformity 24.27 10.78 12 124073 48468 110416746
Injection site haemorrhage 24.16 10.78 4 124081 33024 110432190
Hepatic fibrosis 24.15 10.78 37 124048 8029 110457185
Stoma site pain 24.15 10.78 19 124066 1944 110463270
Prinzmetal angina 23.77 10.78 20 124065 2249 110462965
Autoimmune disorder 23.77 10.78 23 124062 65460 110399754
Cachexia 23.75 10.78 48 124037 12957 110452257
Dermatitis 23.72 10.78 77 124008 27760 110437454
Hypertrichosis 23.59 10.78 18 124067 1760 110463454
Oesophageal carcinoma recurrent 23.59 10.78 7 124078 73 110465141
Diaphragmatic operation 23.57 10.78 6 124079 33 110465181
Onychomycosis 23.49 10.78 7 124078 38524 110426690
Ischiorectal hernia 23.49 10.78 5 124080 10 110465204
Lower limb fracture 23.47 10.78 30 124055 75318 110389896
Retinitis 23.46 10.78 4 124081 32323 110432891
Coronavirus infection 23.42 10.78 40 124045 9505 110455709
Bladder hypertrophy 23.40 10.78 15 124070 1109 110464105
Malaise 23.25 10.78 575 123510 671244 109793970
Hepatectomy 23.10 10.78 10 124075 328 110464886
Minimal residual disease 23.08 10.78 14 124071 939 110464275
Short-bowel syndrome 23.02 10.78 13 124072 763 110464451
Interventricular septum rupture 22.85 10.78 6 124079 38 110465176
Xeroderma 22.82 10.78 12 124073 611 110464603
Bone cyst 22.79 10.78 24 124061 3579 110461635
International normalised ratio increased 22.70 10.78 39 124046 86733 110378481
Malignant ascites 22.61 10.78 16 124069 1394 110463820
Oesophageal haemorrhage 22.51 10.78 18 124067 1885 110463329
Overgrowth fungal 22.51 10.78 8 124077 153 110465061
Underdose 22.29 10.78 23 124062 63531 110401683
Hypoglycaemia 22.26 10.78 62 124023 116042 110349172
Oesophageal fistula 22.23 10.78 11 124074 492 110464722
Irritability 22.22 10.78 13 124072 47796 110417418
Pulmonary congestion 22.10 10.78 4 124081 30962 110434252
Injection site swelling 22.09 10.78 22 124063 61768 110403446
Therapy non-responder 22.07 10.78 96 123989 157211 110308003
Hyperthermia 22.02 10.78 63 124022 21209 110444005
Swelling face 21.93 10.78 44 124041 92277 110372937
Electrolyte imbalance 21.90 10.78 91 123994 36937 110428277
Vascular access complication 21.90 10.78 20 124065 2508 110462706
Dry mouth 21.84 10.78 133 123952 199815 110265399
Angioedema 21.68 10.78 49 124036 98451 110366763
Incorrect dose administered 21.66 10.78 53 124032 103588 110361626
Cranial nerve disorder 21.45 10.78 15 124070 1282 110463932
Disability 21.37 10.78 4 124081 30219 110434995
Systemic infection 21.32 10.78 39 124046 9780 110455434
Aggression 21.26 10.78 21 124064 59189 110406025
Wound infection 21.22 10.78 48 124037 96417 110368797
Perineal disorder 21.21 10.78 6 124079 52 110465162
Toxic erythema of chemotherapy 21.20 10.78 10 124075 402 110464812
Hepatitis B surface antigen positive 21.17 10.78 8 124077 183 110465031
Myeloid leukaemia 21.16 10.78 13 124072 892 110464322
Full blood count abnormal 21.16 10.78 19 124066 56033 110409181
Chemotherapy cardiotoxicity attenuation 21.15 10.78 5 124080 19 110465195
Neutropenic sepsis 20.96 10.78 79 124006 30667 110434547
Optic neuropathy 20.94 10.78 26 124059 4632 110460582
Blood creatine phosphokinase increased 20.85 10.78 31 124054 73046 110392168
Thrombotic microangiopathy 20.80 10.78 76 124009 29073 110436141
Plasma cell myeloma 20.72 10.78 24 124061 62912 110402302
Toxic skin eruption 20.70 10.78 73 124012 27442 110437772
Encephalitis 20.69 10.78 57 124028 18782 110446432
Organic brain syndrome 20.63 10.78 11 124074 576 110464638
Ear infection 20.57 10.78 24 124061 62708 110402506
Renal failure 20.57 10.78 363 123722 226211 110239003
Pancreatic carcinoma recurrent 20.55 10.78 8 124077 199 110465015
Portal vein dilatation 20.53 10.78 6 124079 59 110465155
Hyperthyroidism 20.42 10.78 4 124081 29257 110435957
Mucosal disorder 20.41 10.78 25 124060 4392 110460822
Hypoacusis 20.38 10.78 7 124078 35184 110430030
Escherichia pyelonephritis 20.37 10.78 13 124072 954 110464260
Sleep apnoea syndrome 20.26 10.78 10 124075 40437 110424777
Poisoning 20.26 10.78 4 124081 29101 110436113
Metastases to central nervous system 20.25 10.78 64 124021 22753 110442461
Panic attack 20.10 10.78 4 124081 28936 110436278
Radiation interaction 20.09 10.78 6 124079 64 110465150
Large intestine polyp 19.95 10.78 49 124036 15068 110450146
Nephropathy toxic 19.90 10.78 72 124013 27406 110437808
Injection site pruritus 19.80 10.78 17 124068 51241 110413973
Myelodysplastic syndrome 19.78 10.78 89 123996 37395 110427819
Biliary tract infection 19.74 10.78 16 124069 1708 110463506
Peritoneal disorder 19.66 10.78 12 124073 814 110464400
Meningitis streptococcal 19.60 10.78 8 124077 226 110464988
Sinus congestion 19.57 10.78 5 124080 30454 110434760
Respiratory arrest 19.45 10.78 22 124063 58277 110406937
Drug interaction 19.27 10.78 421 123664 499762 109965452
Troponin I increased 19.21 10.78 27 124058 5425 110459789
Atypical haemolytic uraemic syndrome 19.15 10.78 15 124070 1525 110463689
Visceral venous thrombosis 19.13 10.78 5 124080 31 110465183
Procedural pain 19.05 10.78 8 124077 35557 110429657
Anal erosion 19.02 10.78 6 124079 78 110465136
Viral hepatitis carrier 19.00 10.78 5 124080 32 110465182
Liver function test abnormal 18.95 10.78 30 124055 68920 110396294
Coronary artery disease 18.95 10.78 32 124053 71658 110393556
Ischaemic stroke 18.88 10.78 94 123991 41169 110424045
Heart rate increased 18.85 10.78 90 123995 143744 110321470
Adverse reaction 18.74 10.78 5 124080 29589 110435625
Eczema impetiginous 18.74 10.78 5 124080 34 110465180
Liver function test increased 18.73 10.78 45 124040 88503 110376711
Pulmonary artery thrombosis 18.62 10.78 15 124070 1587 110463627
Injection site bruising 18.61 10.78 18 124067 51245 110413969
Coagulopathy 18.58 10.78 93 123992 40818 110424396
Anorectal disorder 18.57 10.78 19 124066 2740 110462474
Rectal cancer metastatic 18.45 10.78 10 124075 541 110464673
Chronic kidney disease 18.43 10.78 36 124049 76255 110388959
Walking aid user 18.42 10.78 3 124082 25072 110440142
Jugular vein occlusion 18.42 10.78 6 124079 87 110465127
Balanoposthitis 18.41 10.78 14 124071 1362 110463852
Lip swelling 18.16 10.78 18 124067 50649 110414565
Catheter site extravasation 18.10 10.78 10 124075 562 110464652
Skin discolouration 18.07 10.78 17 124068 49029 110416185
Dysphagia 18.07 10.78 257 123828 153343 110311871
Gastrointestinal obstruction 18.01 10.78 17 124068 2223 110462991
Mucocutaneous rash 17.99 10.78 6 124079 94 110465120
Rectal adenocarcinoma 17.93 10.78 15 124070 1674 110463540
Evans syndrome 17.82 10.78 11 124074 761 110464453
Rheumatoid arthritis 17.80 10.78 233 123852 299380 110165834
Haematopoietic stem cell mobilisation 17.76 10.78 9 124076 424 110464790
Hepatotoxicity 17.76 10.78 127 123958 63273 110401941
Agitation 17.74 10.78 66 124019 112985 110352229
Guillain-Barre syndrome 17.69 10.78 38 124047 10706 110454508
Anal erythema 17.66 10.78 8 124077 293 110464921
Oral pain 17.63 10.78 86 123999 37358 110427856
Pneumatosis 17.55 10.78 12 124073 989 110464225
Aortic intramural haematoma 17.51 10.78 7 124078 187 110465027
Hypophagia 17.49 10.78 110 123975 52516 110412698
Disseminated intravascular coagulation 17.46 10.78 92 123993 41194 110424020
Blood culture positive 17.44 10.78 34 124051 8942 110456272
Craniocervical syndrome 17.43 10.78 6 124079 104 110465110
Depilation 17.41 10.78 5 124080 46 110465168
Palpitations 17.34 10.78 106 123979 159106 110306108
Cerebral vasoconstriction 17.33 10.78 14 124071 1487 110463727
Gastroenteritis aeromonas 17.31 10.78 5 124080 47 110465167
Retinitis viral 17.26 10.78 9 124076 450 110464764
Dysaesthesia 17.21 10.78 29 124056 6818 110458396
Cerebral haemorrhage 17.17 10.78 29 124056 64939 110400275
Depressed mood 17.15 10.78 26 124059 60783 110404431
Tumour perforation 16.98 10.78 10 124075 635 110464579
Glycosylated haemoglobin increased 16.97 10.78 3 124082 23616 110441598
Drug intolerance 16.88 10.78 338 123747 406174 110059040
Prostatic calcification 16.87 10.78 6 124079 115 110465099
Failure to thrive 16.86 10.78 43 124042 13531 110451683
Pulmonary infarction 16.82 10.78 22 124063 4129 110461085
Duodenal perforation 16.72 10.78 18 124067 2752 110462462
Post procedural diarrhoea 16.71 10.78 9 124076 481 110464733
Herpes simplex 16.62 10.78 47 124038 15717 110449497
Vasospasm 16.58 10.78 14 124071 1582 110463632
Product prescribing error 16.45 10.78 20 124065 51311 110413903
Rhinovirus infection 16.40 10.78 39 124046 11750 110453464
Abortion spontaneous 16.40 10.78 9 124076 34273 110430941
Intracardiac thrombus 16.34 10.78 22 124063 4246 110460968
Brief psychotic disorder with marked stressors 16.29 10.78 8 124077 352 110464862
Peritoneal neoplasm 16.27 10.78 6 124079 128 110465086
Pleuroparenchymal fibroelastosis 16.23 10.78 8 124077 355 110464859
Nephrolithiasis 16.21 10.78 31 124054 66181 110399033
Deep vein thrombosis postoperative 16.11 10.78 26 124059 59265 110405949
Product administration error 16.09 10.78 11 124074 37206 110428008
Product label confusion 16.03 10.78 3 124082 22674 110442540
Granulocyte count decreased 16.00 10.78 21 124064 3953 110461261
Intestinal strangulation 15.99 10.78 5 124080 63 110465151
Cardiac pacemaker evaluation 15.93 10.78 6 124079 136 110465078
Restlessness 15.92 10.78 24 124061 56235 110408979
Rectal cancer recurrent 15.92 10.78 5 124080 64 110465150
Injection site mass 15.89 10.78 4 124081 24609 110440605
Temperature difference of extremities 15.87 10.78 4 124081 21 110465193
Tumour fistulisation 15.77 10.78 6 124079 140 110465074
Bladder tamponade 15.77 10.78 10 124075 726 110464488
Electromyogram abnormal 15.73 10.78 6 124079 141 110465073
Red cell fragmentation syndrome 15.71 10.78 5 124080 67 110465147
Hydronephrosis 15.70 10.78 55 124030 20610 110444604
Toxic encephalopathy 15.69 10.78 45 124040 15169 110450045
Nasal congestion 15.67 10.78 57 124028 98225 110366989
Obstruction gastric 15.67 10.78 15 124070 1996 110463218
Volvulus of small bowel 15.61 10.78 6 124079 144 110465070
Cancer fatigue 15.57 10.78 8 124077 388 110464826
Adenocarcinoma metastatic 15.49 10.78 8 124077 392 110464822
Multiple-drug resistance 15.49 10.78 41 124044 13194 110452020
Abdominal abscess 15.46 10.78 32 124053 8787 110456427
Portal vein embolisation 15.42 10.78 4 124081 24 110465190
Pleural fistula 15.42 10.78 4 124081 24 110465190
Therapy interrupted 15.35 10.78 20 124065 49802 110415412
Dysstasia 15.29 10.78 9 124076 32977 110432237
Endometrial dysplasia 15.28 10.78 4 124081 25 110465189
Periportal sinus dilatation 15.27 10.78 6 124079 153 110465061
Normal newborn 15.26 10.78 3 124082 21893 110443321
Oesophageal varices haemorrhage 15.26 10.78 23 124062 4922 110460292
Allodynia 15.22 10.78 15 124070 2068 110463146
Blood creatinine increased 15.19 10.78 289 123796 182600 110282614
Anal fissure 15.19 10.78 34 124051 9847 110455367
Nail disorder 15.19 10.78 26 124059 57909 110407305
Creatinine renal clearance decreased 15.18 10.78 3 124082 21812 110443402
Thrombotic thrombocytopenic purpura 15.13 10.78 28 124057 7083 110458131
Metastases to bone marrow 15.10 10.78 11 124074 1003 110464211
Transposition of the great vessels 15.01 10.78 5 124080 78 110465136
Respiratory tract congestion 14.91 10.78 8 124077 30849 110434365
Perineal abscess 14.90 10.78 10 124075 799 110464415
Cardiac arrest 14.84 10.78 145 123940 196608 110268606
Streptococcal bacteraemia 14.81 10.78 22 124063 4647 110460567
Epilepsy 14.77 10.78 60 124025 100149 110365065
Paraesthesia mucosal 14.65 10.78 4 124081 30 110465184
Cutaneous tuberculosis 14.65 10.78 7 124078 290 110464924
Lung neoplasm malignant 14.63 10.78 10 124075 33832 110431382
Viral infection 14.62 10.78 106 123979 53033 110412181
Biliary obstruction 14.58 10.78 24 124061 5534 110459680
Full blood count decreased 14.54 10.78 9 124076 32090 110433124
Perforation bile duct 14.51 10.78 5 124080 87 110465127
Granulomatous lymphadenitis 14.49 10.78 8 124077 449 110464765
Cognitive disorder 14.46 10.78 50 124035 87461 110377753
Maternal exposure timing unspecified 14.39 10.78 3 124082 21010 110444204
Cardiomyopathy 14.38 10.78 75 124010 33450 110431764
Ovarian cystectomy 14.35 10.78 5 124080 90 110465124
Blood bilirubin increased 14.22 10.78 139 123946 75833 110389381
Alanine aminotransferase abnormal 14.22 10.78 32 124053 9302 110455912
Musculoskeletal pain 14.17 10.78 134 123951 182889 110282325
Neurosarcoidosis 14.17 10.78 8 124077 469 110464745
Red blood cell sedimentation rate increased 14.14 10.78 43 124042 78259 110386955
Hemiparesis 14.12 10.78 91 123994 43812 110421402
Product intolerance 14.11 10.78 4 124081 35 110465179
Iatrogenic infection 14.10 10.78 5 124080 95 110465119
Fingerprint loss 14.10 10.78 5 124080 95 110465119
Cardiac murmur 14.09 10.78 5 124080 24623 110440591
Peripheral motor neuropathy 14.05 10.78 20 124065 4066 110461148
Taste disorder 14.01 10.78 33 124052 65354 110399860
Benign hydatidiform mole 13.91 10.78 5 124080 99 110465115
Device issue 13.90 10.78 11 124074 34524 110430690
Axonal neuropathy 13.89 10.78 15 124070 2303 110462911
Vocal cord paralysis 13.87 10.78 17 124068 2989 110462225
Ear pain 13.85 10.78 24 124061 53202 110412012
Abnormal behaviour 13.84 10.78 14 124071 39025 110426189
Gastric varices haemorrhage 13.81 10.78 8 124077 493 110464721
Eye pruritus 13.76 10.78 10 124075 32765 110432449
Exfoliative rash 13.72 10.78 21 124064 4553 110460661
Immunodeficiency 13.68 10.78 14 124071 38824 110426390
Rectal abscess 13.68 10.78 16 124069 2680 110462534
Traumatic fracture 13.63 10.78 11 124074 1167 110464047
Thrombophlebitis 13.62 10.78 28 124057 7651 110457563
Metastatic neoplasm 13.61 10.78 24 124061 5849 110459365
Haptoglobin decreased 13.59 10.78 13 124072 1728 110463486
Parkinsonism 13.58 10.78 4 124081 22183 110443031
Muscle rigidity 13.54 10.78 5 124080 24026 110441188
Dihydropyrimidine dehydrogenase deficiency 13.50 10.78 6 124079 210 110465004
Perioral dermatitis 13.49 10.78 9 124076 712 110464502
Radiation hepatitis 13.49 10.78 3 124082 8 110465206
Escherichia bacteraemia 13.47 10.78 33 124052 10131 110455083
Breast cancer 13.46 10.78 14 124071 38528 110426686
Acute endocarditis 13.45 10.78 4 124081 42 110465172
Tinnitus 13.42 10.78 30 124055 60510 110404704
Type I hypersensitivity 13.39 10.78 25 124060 6368 110458846
Therapeutic response unexpected 13.37 10.78 5 124080 23838 110441376
Pustule 13.32 10.78 18 124067 3486 110461728
Delusion 13.29 10.78 5 124080 23750 110441464
Pulmonary toxicity 13.28 10.78 47 124038 17699 110447515
Cerebral toxoplasmosis 13.27 10.78 17 124068 3125 110462089
Schizophrenia 13.24 10.78 4 124081 21822 110443392
Gastric ulcer perforation, obstructive 13.23 10.78 3 124082 9 110465205
Hepatic venous pressure gradient abnormal 13.23 10.78 3 124082 9 110465205
Abdominal infection 13.19 10.78 21 124064 4710 110460504
Seasonal allergy 13.14 10.78 3 124082 19719 110445495
Inferior vena cava stenosis 13.13 10.78 5 124080 117 110465097
Face oedema 13.08 10.78 73 124012 33396 110431818
Hypersplenism 13.00 10.78 9 124076 757 110464457
Acute polyneuropathy 12.98 10.78 9 124076 759 110464455
Anal infection 12.96 10.78 6 124079 231 110464983
Gastrointestinal stoma output increased 12.96 10.78 10 124075 994 110464220
Neuralgia 12.94 10.78 96 123989 48382 110416832
Bronchopulmonary aspergillosis 12.94 10.78 67 124018 29796 110435418
Hernia 12.92 10.78 3 124082 19497 110445717
Cold sweat 12.92 10.78 54 124031 21977 110443237
Dyspnoea 12.92 10.78 1068 123017 1105804 109359410
Occult blood 12.89 10.78 13 124072 1843 110463371
Change of bowel habit 12.88 10.78 16 124069 2853 110462361
Mood altered 12.82 10.78 4 124081 21371 110443843
Pancreatic fistula 12.82 10.78 5 124080 125 110465089
Granulomatous liver disease 12.70 10.78 12 124073 1572 110463642
Cerebrovascular accident 12.68 10.78 136 123949 181148 110284066
Drug clearance increased 12.65 10.78 7 124078 395 110464819
Aphasia 12.58 10.78 111 123974 58886 110406328
Cardiomyopathy acute 12.58 10.78 7 124078 399 110464815
Eyelash changes 12.57 10.78 3 124082 12 110465202
Limbic encephalitis 12.56 10.78 9 124076 799 110464415
Mental disorder 12.55 10.78 15 124070 38776 110426438
Head injury 12.52 10.78 18 124067 42999 110422215
Drug reaction with eosinophilia and systemic symptoms 12.46 10.78 144 123941 81951 110383263
Sputum discoloured 12.43 10.78 8 124077 27937 110437277
Bacterial disease carrier 12.41 10.78 14 124071 2255 110462959
Neuropathic muscular atrophy 12.41 10.78 4 124081 56 110465158
Retroperitoneal abscess 12.40 10.78 8 124077 598 110464616
Respiratory distress 12.40 10.78 125 123960 68749 110396465
Microangiopathic haemolytic anaemia 12.39 10.78 13 124072 1930 110463284
Joint injury 12.38 10.78 16 124069 39978 110425236
Fistula of small intestine 12.36 10.78 10 124075 1065 110464149
Tracheal inflammation 12.32 10.78 5 124080 139 110465075
Acinetobacter sepsis 12.26 10.78 5 124080 141 110465073
Faeces discoloured 12.23 10.78 12 124073 33936 110431278
Pneumomediastinum 12.22 10.78 21 124064 5015 110460199
Ulcer haemorrhage 12.22 10.78 5 124080 22566 110442648
Skin fissures 12.11 10.78 57 124028 24401 110440813
Hepatitis B DNA increased 12.11 10.78 9 124076 846 110464368
Drug tolerance decreased 12.09 10.78 8 124077 27532 110437682
Hepatic vein stenosis 12.09 10.78 4 124081 61 110465153
Palmar erythema 12.07 10.78 14 124071 2324 110462890
Glomerular filtration rate decreased 11.94 10.78 9 124076 28947 110436267
Multiple sclerosis 11.93 10.78 7 124078 25691 110439523
Haemoglobinuria 11.90 10.78 9 124076 868 110464346
Dysphonia 11.89 10.78 134 123951 75795 110389419
Urge incontinence 11.88 10.78 11 124074 1404 110463810
Movement disorder 11.86 10.78 14 124071 36390 110428824
Leukocytosis 11.86 10.78 102 123983 53726 110411488
Dermatitis exfoliative generalised 11.85 10.78 33 124052 10939 110454275
Mydriasis 11.84 10.78 5 124080 22152 110443062
Left ventricular dysfunction 11.82 10.78 55 124030 23438 110441776
C-reactive protein 11.79 10.78 10 124075 30321 110434893
White blood cell count decreased 11.78 10.78 339 123746 229051 110236163
Fanconi syndrome 11.77 10.78 17 124068 3502 110461712
Acne 11.73 10.78 71 124014 33449 110431765
Ulcerative gastritis 11.72 10.78 5 124080 158 110465056
Nephrectasia 11.71 10.78 3 124082 17 110465197
Intentional dose omission 11.62 10.78 4 124081 20076 110445138
Hemianaesthesia 11.61 10.78 7 124078 464 110464750
Fluid balance positive 11.58 10.78 4 124081 70 110465144
Coordination abnormal 11.53 10.78 7 124078 25221 110439993
Hypocapnia 11.50 10.78 9 124076 913 110464301
Blepharospasm 11.50 10.78 28 124057 54823 110410391
Pseudocirrhosis 11.50 10.78 9 124076 914 110464300
Sudden death 11.46 10.78 56 124029 24339 110440875
Gastroenteritis norovirus 11.43 10.78 17 124068 3594 110461620
Therapy naive 11.43 10.78 4 124081 73 110465141
Optic disc hyperaemia 11.43 10.78 3 124082 19 110465195
Endocarditis 11.40 10.78 37 124048 13334 110451880
Hypervolaemia 11.38 10.78 24 124061 49436 110415778
Reading disorder 11.36 10.78 10 124075 1195 110464019
Rash pruritic 11.36 10.78 64 124021 98005 110367209
Perforation 11.35 10.78 12 124073 1798 110463416
Needle issue 11.32 10.78 3 124082 17837 110447377
Petechiae 11.30 10.78 54 124031 23263 110441951
Skin hyperpigmentation 11.28 10.78 28 124057 8668 110456546
Pemphigoid 11.27 10.78 4 124081 19703 110445511
Gastric perforation 11.24 10.78 20 124065 4909 110460305
Skin haemorrhage 11.19 10.78 7 124078 24820 110440394
Pulmonary arterial hypertension 11.18 10.78 12 124073 32556 110432658
Stenotrophomonas infection 11.15 10.78 22 124063 5836 110459378
Adrenal insufficiency 11.13 10.78 19 124066 42371 110422843
Blood glucose decreased 11.12 10.78 10 124075 29478 110435736
Product substitution issue 11.11 10.78 6 124079 23055 110442159
Vitamin B1 deficiency 11.10 10.78 9 124076 961 110464253
Muscular weakness 11.10 10.78 204 123881 248264 110216950
Electrocardiogram abnormal 11.08 10.78 46 124039 18663 110446551
Hypothermia 11.07 10.78 8 124077 26294 110438920
Subacute cutaneous lupus erythematosus 11.05 10.78 20 124065 4974 110460240
Dyskinesia 10.99 10.78 26 124059 51420 110413794
Therapy cessation 10.98 10.78 21 124064 44836 110420378
Chemotherapeutic drug level increased 10.95 10.78 7 124078 515 110464699
Pancreatic carcinoma metastatic 10.95 10.78 18 124067 4146 110461068
Congestive cardiomyopathy 10.94 10.78 38 124047 14181 110451033
Hypertransaminasaemia 10.91 10.78 55 124030 24200 110441014
Injection site warmth 10.91 10.78 3 124082 17402 110447812
Bronchitis 10.90 10.78 118 123967 156914 110308300
Splenic vein thrombosis 10.90 10.78 9 124076 986 110464228
Acute promyelocytic leukaemia 10.89 10.78 12 124073 1884 110463330
Brachiocephalic vein thrombosis 10.88 10.78 6 124079 336 110464878
Venous injury 10.88 10.78 9 124076 989 110464225
Splenic abscess 10.86 10.78 9 124076 991 110464223
Hepatitis 10.86 10.78 58 124027 89996 110375218
Pain in jaw 10.83 10.78 26 124059 51151 110414063
Rectal cancer 10.81 10.78 17 124068 3772 110461442
Gallbladder polyp 10.80 10.78 10 124075 1277 110463937
Proctectomy 10.78 10.78 6 124079 342 110464872

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V03AF03 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Detoxifying agents for antineoplastic treatment
ATC V03AF06 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Detoxifying agents for antineoplastic treatment
FDA CS M0008658 Folic Acid
MeSH PA D000931 Antidotes
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
MeSH PA D018977 Micronutrients
MeSH PA D020011 Protective Agents
FDA EPC N0000178369 Folate Analog
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:35442 antiparasitic agent
CHEBI has role CHEBI:35718 antifungal agent
CHEBI has role CHEBI:66981 ophthalmology drug

Related Drugs by ATC class:

V03AF Detoxifying agents for antineoplastic treatment 10 drugs
amifostineargininedexrazoxaneglucarpidaselevofolinic acidlysinemesnapaliferminrasburicasetrilaciclib

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Megaloblastic anemia indication 53165003 DOID:13382
Folic acid deficiency indication 190633005
Bone Marrow Suppression due to Folic Acid Antagonism indication
Methotrexate Toxicity indication
Trimethoprim Toxicity indication
Trimetrexate Toxicity indication
Sulfadiazine Toxicity indication
Pyrimethamine Toxicity indication
Adjunct to Fluorouracil Treatment of Colorectal Cancer indication
Pernicious anemia contraindication 84027009 DOID:13381
Cobalamin deficiency contraindication 190634004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.61 acidic
pKa2 5.29 acidic
pKa3 10.26 acidic
pKa4 12.96 acidic
pKa5 4.59 Basic
pKa6 2.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thymidylate synthase Enzyme Ki 4.07 WOMBAT-PK
Dihydrofolate reductase Enzyme Ki 5.63 CHEMBL

External reference:

IDSource
4019798 VUID
N0000147887 NUI
D01211 KEGG_DRUG
1492-18-8 SECONDARY_CAS_RN
4018768 VANDF
4019798 VANDF
4031236 VANDF
C0023413 UMLSCUI
CHEBI:15640 CHEBI
CHEMBL1679 ChEMBL_ID
CHEMBL3707260 ChEMBL_ID
CHEMBL1232801 ChEMBL_ID
CHEMBL1201138 ChEMBL_ID
D002955 MESH_DESCRIPTOR_UI
DB00650 DRUGBANK_ID
Q573I9DVLP UNII
135403648 PUBCHEM_CID
225852 RXNORM
1728 MMSL
39896 MMSL
4964 MMSL
51342 MMSL
d00275 MMSL
001050 NDDF
001051 NDDF
009520 NDDF
126223008 SNOMEDCT_US
1528001 SNOMEDCT_US
396065004 SNOMEDCT_US
768550004 SNOMEDCT_US
4816 IUPHAR_LIGAND_ID
690 INN_ID
Q573I9DVLP INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0054-4496 TABLET 5 mg ORAL ANDA 26 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0054-4497 TABLET 10 mg ORAL ANDA 26 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0054-4498 TABLET 15 mg ORAL ANDA 26 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0054-4499 TABLET 25 mg ORAL ANDA 26 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0054-8496 TABLET 5 mg ORAL ANDA 26 sections
LEDERLE LEUCOVORIN HUMAN PRESCRIPTION DRUG LABEL 1 0069-5886 TABLET 5 mg ORAL Unapproved drug for use in drug shortage 2 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9368 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 200 mg INTRAMUSCULAR ANDA 19 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9552 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 350 mg INTRAMUSCULAR ANDA 19 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9553 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 200 mg INTRAMUSCULAR ANDA 19 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9554 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAMUSCULAR ANDA 19 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9555 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 50 mg INTRAMUSCULAR ANDA 19 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0555-0484 TABLET 5 mg ORAL ANDA 26 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0555-0485 TABLET 25 mg ORAL ANDA 26 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0904-7584 TABLET 25 mg ORAL ANDA 17 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 25021-813 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 50 mg INTRAVENOUS ANDA 21 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 25021-814 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS ANDA 21 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 25021-815 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 200 mg INTRAVENOUS ANDA 21 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 25021-816 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 350 mg INTRAVENOUS ANDA 21 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 25021-828 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 21 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 42806-133 TABLET 10 mg ORAL ANDA 16 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 42806-134 TABLET 15 mg ORAL ANDA 16 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 42806-358 TABLET 5 mg ORAL ANDA 16 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 42806-359 TABLET 25 mg ORAL ANDA 16 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 50742-181 TABLET 5 mg ORAL ANDA 18 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 50742-182 TABLET 10 mg ORAL ANDA 18 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 50742-183 TABLET 15 mg ORAL ANDA 18 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 50742-184 TABLET 25 mg ORAL ANDA 18 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 54868-3310 TABLET 5 mg ORAL ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 54868-5915 TABLET 15 mg ORAL ANDA 12 sections
Leucovorin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 60687-227 TABLET 25 mg ORAL ANDA 18 sections