rasburicase 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
enzymes	4994	134774-45-1

Description:

Molecule	Description
Synonyms: rasburicase fasturtec elitek	a recombinant form of enzyme that degrades uric acid to allantoin just downstream of xanthine oxidase; used to treat hyperuricaemia Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

rasburicase
fasturtec
elitek

a recombinant form of enzyme that degrades uric acid to allantoin just downstream of xanthine oxidase; used to treat hyperuricaemia

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
14	mg	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Feb. 23, 2001	EMA
July 12, 2002	FDA	SANOFI SYNTHELABO

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Tumour lysis syndrome	380.45	34.40	83	2170	8907	63477862
Febrile neutropenia	86.06	34.40	53	2200	118396	63368373
Cytokine release syndrome	80.94	34.40	27	2226	14287	63472482
Hypofibrinogenaemia	73.44	34.40	15	2238	1155	63485614
Methaemoglobinaemia	73.17	34.40	17	2236	2386	63484383
Hyperuricaemia	59.60	34.40	17	2236	5353	63481416
Neutropenia	58.84	34.40	49	2204	174956	63311813
Hyperkalaemia	57.29	34.40	31	2222	54172	63432597
Blood phosphorus increased	49.00	34.40	13	2240	3132	63483637
Subdural hygroma	39.52	34.40	7	2246	250	63486519

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Tumour lysis syndrome	568.27	25.53	170	4503	16889	34935369
Methaemoglobinaemia	255.15	25.53	65	4608	3516	34948742
Cytokine release syndrome	119.02	25.53	59	4614	22818	34929440
Thymus hypoplasia	103.61	25.53	21	4652	397	34951861
Lymphoid tissue hypoplasia	103.61	25.53	21	4652	397	34951861
Febrile neutropenia	99.35	25.53	106	4567	136743	34815515
Disseminated aspergillosis	90.56	25.53	21	4652	759	34951499
Haemolytic anaemia	79.16	25.53	35	4638	10444	34941814
Lymphopenia	72.87	25.53	38	4635	16297	34935961
Glucose-6-phosphate dehydrogenase deficiency	59.65	25.53	11	4662	123	34952135

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Tumour lysis syndrome	913.46	23.58	240	6473	23699	79713976
Methaemoglobinaemia	306.67	23.58	75	6638	5482	79732193
Cytokine release syndrome	198.58	23.58	84	6629	35914	79701761
Febrile neutropenia	173.07	23.58	148	6565	230851	79506824
Lymphoid tissue hypoplasia	130.90	23.58	27	6686	903	79736772
Thymus hypoplasia	129.68	23.58	27	6686	946	79736729
Disseminated aspergillosis	125.94	23.58	27	6686	1091	79736584
Haemolytic anaemia	113.11	23.58	46	6667	17774	79719901
Neutropenia	106.79	23.58	126	6587	287584	79450091
Lymphopenia	98.14	23.58	49	6664	30508	79707167

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	V03AF07	VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Detoxifying agents for antineoplastic treatment
FDA CS	M0022307	Urate Oxidase
FDA EPC	N0000175670	Uric Acid-specific Enzyme
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D006074	Gout Suppressants

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hyperuricemia	indication	35885006	DOID:1920

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
009162	NDDF
08GY9K1EUO	UNII
134670005	SNOMEDCT_US
16841	MMSL
283821	RXNORM
395858003	SNOMEDCT_US
4021376	VUID
4021376	VANDF
415249009	SNOMEDCT_US
44374	MMSL

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Pharmaceutical products:

None