All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

rasburicase 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
enzymes	4994	134774-45-1

Description:

Molecule	Description
Synonyms: rasburicase fasturtec elitek	a recombinant form of enzyme that degrades uric acid to allantoin just downstream of xanthine oxidase; used to treat hyperuricaemia Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
14	mg	P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
July 12, 2002	FDA	SANOFI SYNTHELABO
Feb. 23, 2001	EMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Tumour lysis syndrome	497.41	35.36	107	3020	11045	90614275
Cytokine release syndrome	148.73	35.36	50	3077	27923	90597397
Neutropenia	119.99	35.36	82	3045	224822	90400498
Febrile neutropenia	112.10	35.36	69	3058	158280	90467040
Hypofibrinogenaemia	71.48	35.36	15	3112	1355	90623965
Hyperkalaemia	69.18	35.36	37	3090	64927	90560393
Methaemoglobinaemia	64.95	35.36	17	3110	3998	90621322
Hyperuricaemia	60.62	35.36	18	3109	6701	90618619
Blood phosphorus increased	59.01	35.36	16	3111	4302	90621018
Respiratory failure	53.27	35.36	39	3088	118379	90506941
Febrile bone marrow aplasia	46.19	35.36	16	3111	9722	90615598
Renal failure	45.48	35.36	37	3090	130970	90494350
Cerebral haematoma	45.36	35.36	13	3114	4276	90621044
Necrotising colitis	43.84	35.36	10	3117	1328	90623992
Hyperphosphataemia	42.63	35.36	12	3115	3699	90621621
Toxic skin eruption	42.09	35.36	17	3110	15757	90609563
Thrombocytopenia	39.46	35.36	42	3085	208683	90416637
Subdural hygroma	39.17	35.36	7	3120	271	90625049
Multiple organ dysfunction syndrome	38.86	35.36	26	3101	68310	90557010
Cardiovascular insufficiency	36.72	35.36	9	3118	1626	90623694
Haemolytic anaemia	36.08	35.36	14	3113	11683	90613637

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Tumour lysis syndrome	662.46	24.61	211	6442	22020	42592662
Methaemoglobinaemia	344.39	24.61	94	6559	5680	42609002
Lymphoid tissue hypoplasia	233.52	24.61	48	6605	830	42613852
Thymus hypoplasia	228.53	24.61	47	6606	815	42613867
Disseminated aspergillosis	175.43	24.61	43	6610	1687	42612995
Febrile neutropenia	155.87	24.61	167	6486	185536	42429146
Cytokine release syndrome	147.96	24.61	90	6563	44437	42570245
Lymphopenia	134.08	24.61	66	6587	21497	42593185
Haemolytic anaemia	102.80	24.61	46	6607	12081	42602601
Cytomegalovirus viraemia	96.47	24.61	42	6611	10335	42604347
Fungal infection	92.62	24.61	50	6603	19672	42595010
Clostridium difficile colitis	86.42	24.61	49	6604	21203	42593479
Bacterial infection	84.02	24.61	53	6600	27826	42586856
Haemolysis	76.90	24.61	35	6618	9554	42605128
Glucose-6-phosphate dehydrogenase deficiency	73.80	24.61	15	6638	244	42614438
Neutropenia	69.60	24.61	117	6536	199314	42415368
SARS-CoV-2 sepsis	50.89	24.61	11	6642	244	42614438
Enterococcus test positive	50.01	24.61	16	6637	1669	42613013
Multiple organ dysfunction syndrome	49.48	24.61	68	6585	96967	42517715
Acute kidney injury	49.34	24.61	147	6506	367190	42247492
Cutaneous T-cell lymphoma stage I	46.38	24.61	9	6644	114	42614568
Hyperphosphataemia	42.38	24.61	26	6627	12978	42601704
Cellulitis	42.18	24.61	50	6603	61535	42553147
Chronic lymphocytic leukaemia	33.66	24.61	16	6637	4813	42609869
Immune effector cell-associated neurotoxicity syndrome	33.62	24.61	20	6633	9441	42605241
Disseminated intravascular coagulation	33.32	24.61	29	6624	24765	42589917
Hyperkalaemia	33.14	24.61	51	6602	80407	42534275
Escherichia infection	32.65	24.61	21	6632	11375	42603307
Renal ischaemia	30.44	24.61	11	6642	1659	42613023
Febrile bone marrow aplasia	29.76	24.61	19	6634	10162	42604520
Hyperuricaemia	28.57	24.61	18	6635	9406	42605276
Myocardial calcification	28.56	24.61	5	6648	34	42614648
Autoimmune haemolytic anaemia	28.35	24.61	15	6638	5656	42609026
Hyperbilirubinaemia	27.45	24.61	24	6629	20611	42594071
Hypoxia	25.65	24.61	42	6611	69744	42544938

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Tumour lysis syndrome	1122.01	24.15	299	9195	30502	110549303
Methaemoglobinaemia	410.17	24.15	105	9389	9063	110570742
Cytokine release syndrome	294.57	24.15	136	9358	70170	110509635
Febrile neutropenia	273.34	24.15	222	9272	316545	110263260
Lymphoid tissue hypoplasia	266.75	24.15	54	9440	1611	110578194
Thymus hypoplasia	260.13	24.15	53	9441	1634	110578171
Disseminated aspergillosis	217.84	24.15	49	9445	2431	110577374
Neutropenia	172.08	24.15	185	9309	374435	110205370
Lymphopenia	169.01	24.15	78	9416	40092	110539713
Haemolytic anaemia	163.12	24.15	63	9431	20857	110558948
Cytomegalovirus viraemia	119.20	24.15	48	9446	17716	110562089
Bacterial infection	112.81	24.15	62	9432	45974	110533831
Fungal infection	101.82	24.15	60	9434	50746	110529059
Clostridium difficile colitis	99.18	24.15	56	9438	43722	110536083
Hyperkalaemia	95.81	24.15	85	9409	135711	110444094
Acute kidney injury	87.87	24.15	178	9316	635252	109944553
Haemolysis	87.11	24.15	37	9457	15602	110564203
Multiple organ dysfunction syndrome	85.87	24.15	84	9410	151626	110428179
Glucose-6-phosphate dehydrogenase deficiency	78.76	24.15	16	9478	485	110579320
Hyperuricaemia	76.39	24.15	33	9461	14498	110565307
Hyperphosphataemia	72.59	24.15	33	9461	16348	110563457
Blood phosphorus increased	69.53	24.15	32	9462	16308	110563497
Sepsis	63.15	24.15	106	9388	327240	110252565
Thrombocytopenia	58.23	24.15	106	9388	348779	110231026
Disseminated intravascular coagulation	58.14	24.15	39	9455	41247	110538558
SARS-CoV-2 sepsis	57.02	24.15	11	9483	254	110579551
Respiratory failure	55.89	24.15	80	9414	215252	110364553
Febrile bone marrow aplasia	55.50	24.15	28	9466	17437	110562368
Blood lactate dehydrogenase increased	51.01	24.15	37	9457	44297	110535508
Enterococcus test positive	50.85	24.15	16	9478	2888	110576917
Immune effector cell-associated neurotoxicity syndrome	50.81	24.15	25	9469	14757	110565048
Cutaneous T-cell lymphoma stage I	49.90	24.15	9	9485	142	110579663
Cellulitis	47.00	24.15	56	9438	125960	110453845
Pseudomonal sepsis	45.77	24.15	20	9474	9026	110570779
Hypoxia	44.15	24.15	55	9439	129460	110450345
Chronic lymphocytic leukaemia	43.06	24.15	17	9477	5951	110573854
Renal failure	41.83	24.15	72	9422	226502	110353303
Blood uric acid increased	39.41	24.15	24	9470	21505	110558300
Hypocalcaemia	38.45	24.15	37	9457	65329	110514476
Pyrexia	37.27	24.15	164	9330	898101	109681704
Encephalopathy	36.97	24.15	40	9454	81015	110498790
Necrotising colitis	36.29	24.15	11	9483	1754	110578051
Anaemia	36.10	24.15	116	9378	546970	110032835
Hypertriglyceridaemia	34.78	24.15	20	9474	16134	110563671
Renal ischaemia	33.32	24.15	11	9483	2312	110577493
Cardiovascular insufficiency	33.29	24.15	12	9482	3276	110576529
Hepatocellular injury	32.33	24.15	30	9464	50612	110529193
Cerebral haematoma	32.24	24.15	16	9478	9616	110570189
Neutropenic sepsis	31.64	24.15	24	9470	30722	110549083
Haemophagocytic lymphohistiocytosis	31.09	24.15	24	9470	31535	110548270
Autoimmune haemolytic anaemia	30.84	24.15	16	9478	10551	110569254
Escherichia infection	29.98	24.15	21	9473	23795	110556010
Enterococcal bacteraemia	29.73	24.15	12	9482	4449	110575356
Inappropriate antidiuretic hormone secretion	29.60	24.15	24	9470	33827	110545978
Pancytopenia	29.14	24.15	59	9435	209554	110370251
Pain	28.68	24.15	24	9470	954931	109624874
Hypofibrinogenaemia	28.61	24.15	10	9484	2497	110577308
Haemophilus bacteraemia	28.04	24.15	6	9488	235	110579570
Chronic lymphocytic leukaemia recurrent	27.99	24.15	8	9486	1041	110578764
Subdural hygroma	27.37	24.15	7	9487	599	110579206
Nervous system disorder	26.71	24.15	22	9472	31699	110548106
Transient aphasia	26.28	24.15	7	9487	702	110579103
Fatigue	26.24	24.15	40	9454	1215918	109363887
Leukopenia	25.77	24.15	46	9448	148745	110431060
Transverse sinus thrombosis	25.63	24.15	7	9487	771	110579034
Respiratory distress	24.67	24.15	30	9464	68844	110510961
Product use in unapproved indication	24.34	24.15	89	9405	447288	110132517

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	V03AF07	VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Detoxifying agents for antineoplastic treatment
FDA CS	M0022307	Urate Oxidase
MeSH PA	D006074	Gout Suppressants
MeSH PA	D018501	Antirheumatic Agents
FDA EPC	N0000175670	Uric Acid-specific Enzyme
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:35845	gout suppressant

Related Drugs by ATC class:

V03AF Detoxifying agents for antineoplastic treatment 10 drugs

amifostineargininedexrazoxaneglucarpidaseleucovorinlevofolinic acidlysinemesnapalifermintrilaciclib

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hyperuricemia	indication	35885006	DOID:1920

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
08GY9K1EUO	UNII
D05704	KEGG_DRUG
4021376	VUID
N0000148794	NUI
4021376	VANDF
C0937932	UMLSCUI
CHEBI:749439	CHEBI
CHEMBL1201594	ChEMBL_ID
DB00049	DRUGBANK_ID
7851	INN_ID
C469709	MESH_SUPPLEMENTAL_RECORD_UI
7467	IUPHAR_LIGAND_ID
283821	RXNORM
16841	MMSL
44374	MMSL
53180	MMSL
d04805	MMSL
009162	NDDF
134670005	SNOMEDCT_US
395858003	SNOMEDCT_US
415249009	SNOMEDCT_US

Pharmaceutical products:

None