Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, produced by Streptomyces strains | 1048 | 114-07-8 |
Dose | Unit | Route |
---|---|---|
1 | g | O |
2 | g | O |
1 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 2.10 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 5 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 90.88 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 35 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.95 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 5.60 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.10 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
June 24, 1964 | FDA | ARBOR PHARMS LLC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 4895.38 | 11.96 | 2286 | 19960 | 272919 | 55996902 |
International normalised ratio fluctuation | 240.38 | 11.96 | 72 | 22174 | 2342 | 56267479 |
Bloody discharge | 178.03 | 11.96 | 51 | 22195 | 1414 | 56268407 |
Lyme disease | 135.27 | 11.96 | 49 | 22197 | 2909 | 56266912 |
Seronegative arthritis | 84.35 | 11.96 | 34 | 22212 | 2702 | 56267119 |
Exposure during pregnancy | 67.19 | 11.96 | 159 | 22087 | 136183 | 56133638 |
Necrosis ischaemic | 62.81 | 11.96 | 20 | 22226 | 799 | 56269022 |
Abortion spontaneous | 59.93 | 11.96 | 80 | 22166 | 43673 | 56226148 |
Anaphylactic reaction | 59.09 | 11.96 | 93 | 22153 | 58902 | 56210919 |
Vomiting | 54.13 | 11.96 | 359 | 21887 | 497869 | 55771952 |
Faecal volume decreased | 50.72 | 11.96 | 12 | 22234 | 152 | 56269669 |
Drug interaction | 49.92 | 11.96 | 189 | 22057 | 209566 | 56060255 |
Beta haemolytic streptococcal infection | 49.78 | 11.96 | 21 | 22225 | 1873 | 56267948 |
Pneumonia streptococcal | 48.69 | 11.96 | 20 | 22226 | 1668 | 56268153 |
Wheezing | 47.72 | 11.96 | 97 | 22149 | 74929 | 56194892 |
Amniotic cavity infection | 47.68 | 11.96 | 18 | 22228 | 1200 | 56268621 |
Dislocation of vertebra | 43.60 | 11.96 | 27 | 22219 | 5388 | 56264433 |
Pneumococcal infection | 39.34 | 11.96 | 12 | 22234 | 415 | 56269406 |
Mass excision | 38.49 | 11.96 | 11 | 22235 | 302 | 56269519 |
Ototoxicity | 37.71 | 11.96 | 15 | 22231 | 1151 | 56268670 |
Umbilical erythema | 36.30 | 11.96 | 8 | 22238 | 72 | 56269749 |
Completed suicide | 36.15 | 11.96 | 5 | 22241 | 133828 | 56135993 |
Death | 35.46 | 11.96 | 50 | 22196 | 341376 | 55928445 |
Pain | 35.28 | 11.96 | 139 | 22107 | 663045 | 55606776 |
Vertigo positional | 34.38 | 11.96 | 18 | 22228 | 2611 | 56267210 |
Drug intolerance | 33.10 | 11.96 | 198 | 22048 | 264620 | 56005201 |
Purpura senile | 32.81 | 11.96 | 11 | 22235 | 518 | 56269303 |
Rash | 31.98 | 11.96 | 316 | 21930 | 492731 | 55777090 |
Spondylitis | 31.26 | 11.96 | 18 | 22228 | 3147 | 56266674 |
Caesarean section | 31.07 | 11.96 | 35 | 22211 | 16056 | 56253765 |
Therapeutic product effect incomplete | 30.73 | 11.96 | 102 | 22144 | 105929 | 56163892 |
Stevens-Johnson syndrome | 28.84 | 11.96 | 40 | 22206 | 22623 | 56247198 |
Tarsal tunnel syndrome | 28.71 | 11.96 | 10 | 22236 | 529 | 56269292 |
Bronchial obstruction | 28.70 | 11.96 | 13 | 22233 | 1375 | 56268446 |
Premature baby | 27.65 | 11.96 | 36 | 22210 | 19169 | 56250652 |
Lip swelling | 27.10 | 11.96 | 42 | 22204 | 26230 | 56243591 |
Infection | 26.48 | 11.96 | 152 | 22094 | 200054 | 56069767 |
Serum sickness-like reaction | 26.08 | 11.96 | 9 | 22237 | 463 | 56269358 |
Wound infection | 25.91 | 11.96 | 31 | 22215 | 15162 | 56254659 |
Spinal fusion surgery | 25.61 | 11.96 | 18 | 22228 | 4438 | 56265383 |
Premature rupture of membranes | 24.52 | 11.96 | 18 | 22228 | 4747 | 56265074 |
Abdominal pain upper | 23.33 | 11.96 | 135 | 22111 | 178178 | 56091643 |
Drug ineffective | 23.27 | 11.96 | 242 | 22004 | 918747 | 55351074 |
Oligohydramnios | 22.93 | 11.96 | 19 | 22227 | 5975 | 56263846 |
Drug tolerance decreased | 22.27 | 11.96 | 27 | 22219 | 13384 | 56256437 |
Death neonatal | 21.74 | 11.96 | 9 | 22237 | 765 | 56269056 |
Urticaria | 21.23 | 11.96 | 113 | 22133 | 144563 | 56125258 |
Fall | 20.86 | 11.96 | 72 | 22174 | 357438 | 55912383 |
Alopecia | 20.78 | 11.96 | 54 | 22192 | 293404 | 55976417 |
Resorption bone increased | 20.57 | 11.96 | 10 | 22236 | 1240 | 56268581 |
Mucous stools | 20.22 | 11.96 | 14 | 22232 | 3370 | 56266451 |
Vestibular disorder | 20.02 | 11.96 | 10 | 22236 | 1315 | 56268506 |
Pharyngeal oedema | 19.28 | 11.96 | 25 | 22221 | 13260 | 56256561 |
Ergot poisoning | 19.19 | 11.96 | 5 | 22241 | 96 | 56269725 |
Maternal drugs affecting foetus | 19.19 | 11.96 | 16 | 22230 | 5077 | 56264744 |
Adjustment disorder with depressed mood | 19.16 | 11.96 | 16 | 22230 | 5087 | 56264734 |
Corneal neovascularisation | 18.59 | 11.96 | 5 | 22241 | 109 | 56269712 |
Corneal perforation | 17.78 | 11.96 | 7 | 22239 | 523 | 56269298 |
Nasopharyngitis | 17.76 | 11.96 | 38 | 22208 | 220921 | 56048900 |
Stenotrophomonas infection | 17.24 | 11.96 | 10 | 22236 | 1771 | 56268050 |
Nodule | 16.79 | 11.96 | 28 | 22218 | 18591 | 56251230 |
Ulcerative keratitis | 16.68 | 11.96 | 11 | 22235 | 2444 | 56267377 |
Acute generalised exanthematous pustulosis | 16.60 | 11.96 | 20 | 22226 | 9849 | 56259972 |
Pemphigus | 16.31 | 11.96 | 23 | 22223 | 157189 | 56112632 |
Febrile neutropenia | 16.07 | 11.96 | 11 | 22235 | 105534 | 56164287 |
Anal candidiasis | 15.69 | 11.96 | 3 | 22243 | 12 | 56269809 |
Maternal exposure during pregnancy | 15.55 | 11.96 | 128 | 22118 | 189425 | 56080396 |
Stomatitis | 15.40 | 11.96 | 15 | 22231 | 120795 | 56149026 |
Starvation ketoacidosis | 15.30 | 11.96 | 4 | 22242 | 78 | 56269743 |
Systemic lupus erythematosus | 15.29 | 11.96 | 30 | 22216 | 180048 | 56089773 |
Infantile haemangioma | 14.93 | 11.96 | 4 | 22242 | 86 | 56269735 |
Interstitial lung disease | 14.86 | 11.96 | 53 | 22193 | 57010 | 56212811 |
Benign laryngeal neoplasm | 14.68 | 11.96 | 3 | 22243 | 18 | 56269803 |
Toxicity to various agents | 14.64 | 11.96 | 43 | 22203 | 224521 | 56045300 |
Breast cancer stage III | 14.55 | 11.96 | 16 | 22230 | 7147 | 56262674 |
Cardiac arrest neonatal | 14.47 | 11.96 | 4 | 22242 | 97 | 56269724 |
Synovitis | 14.46 | 11.96 | 26 | 22220 | 161279 | 56108542 |
Corneal deposits | 13.98 | 11.96 | 5 | 22241 | 286 | 56269535 |
Dysphoria | 13.82 | 11.96 | 13 | 22233 | 4829 | 56264992 |
Premature delivery | 13.78 | 11.96 | 32 | 22214 | 27028 | 56242793 |
Jarisch-Herxheimer reaction | 13.51 | 11.96 | 5 | 22241 | 315 | 56269506 |
Product packaging issue | 13.43 | 11.96 | 7 | 22239 | 1006 | 56268815 |
Bronchitis | 13.37 | 11.96 | 83 | 22163 | 112228 | 56157593 |
Anaemia | 12.95 | 11.96 | 58 | 22188 | 267453 | 56002368 |
Stillbirth | 12.83 | 11.96 | 14 | 22232 | 6200 | 56263621 |
Pseudomembranous colitis | 12.80 | 11.96 | 10 | 22236 | 2893 | 56266928 |
Renal impairment neonatal | 12.68 | 11.96 | 3 | 22243 | 38 | 56269783 |
Keratitis | 12.61 | 11.96 | 10 | 22236 | 2957 | 56266864 |
Campylobacter gastroenteritis | 12.56 | 11.96 | 5 | 22241 | 384 | 56269437 |
Walking aid user | 12.42 | 11.96 | 16 | 22230 | 8427 | 56261394 |
Blepharitis | 12.27 | 11.96 | 9 | 22237 | 2371 | 56267450 |
Infusion related reaction | 12.22 | 11.96 | 42 | 22204 | 208889 | 56060932 |
Abdominal pain | 12.20 | 11.96 | 156 | 22090 | 258649 | 56011172 |
Malignant neoplasm progression | 12.12 | 11.96 | 7 | 22239 | 73580 | 56196241 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 485.04 | 14.64 | 284 | 8730 | 72315 | 31616015 |
Toxic epidermal necrolysis | 76.81 | 14.64 | 55 | 8959 | 19469 | 31668861 |
Hyphaema | 72.72 | 14.64 | 19 | 8995 | 521 | 31687809 |
Drug interaction | 64.81 | 14.64 | 166 | 8848 | 208377 | 31479953 |
Product packaging issue | 61.67 | 14.64 | 17 | 8997 | 574 | 31687756 |
Premature baby | 49.37 | 14.64 | 41 | 8973 | 18025 | 31670305 |
Rhabdomyolysis | 42.99 | 14.64 | 70 | 8944 | 63511 | 31624819 |
Dystonia | 42.96 | 14.64 | 30 | 8984 | 10195 | 31678135 |
Stupor | 39.04 | 14.64 | 18 | 8996 | 2766 | 31685564 |
Obstruction gastric | 34.54 | 14.64 | 12 | 9002 | 880 | 31687450 |
Coagulation time prolonged | 34.18 | 14.64 | 13 | 9001 | 1235 | 31687095 |
Acute generalised exanthematous pustulosis | 33.31 | 14.64 | 21 | 8993 | 6019 | 31682311 |
Intraocular pressure increased | 31.05 | 14.64 | 19 | 8995 | 5168 | 31683162 |
Foetal death | 30.77 | 14.64 | 8 | 9006 | 215 | 31688115 |
Eye pain | 29.67 | 14.64 | 26 | 8988 | 12278 | 31676052 |
Deafness bilateral | 29.15 | 14.64 | 11 | 9003 | 1022 | 31687308 |
Brain oedema | 28.73 | 14.64 | 26 | 8988 | 12806 | 31675524 |
Pyloric stenosis | 28.46 | 14.64 | 10 | 9004 | 758 | 31687572 |
Low birth weight baby | 28.23 | 14.64 | 20 | 8994 | 6950 | 31681380 |
Impaired gastric emptying | 27.76 | 14.64 | 15 | 8999 | 3229 | 31685101 |
Foetal exposure during pregnancy | 27.60 | 14.64 | 45 | 8969 | 40831 | 31647499 |
Clonal haematopoiesis | 27.47 | 14.64 | 6 | 9008 | 74 | 31688256 |
Product dispensing error | 26.67 | 14.64 | 18 | 8996 | 5786 | 31682544 |
Foetal arrhythmia | 25.91 | 14.64 | 6 | 9008 | 98 | 31688232 |
Caesarean section | 25.54 | 14.64 | 12 | 9002 | 1924 | 31686406 |
Cellulitis enterococcal | 25.41 | 14.64 | 6 | 9008 | 107 | 31688223 |
SAPHO syndrome | 25.15 | 14.64 | 6 | 9008 | 112 | 31688218 |
Oligohydramnios | 23.12 | 14.64 | 7 | 9007 | 331 | 31687999 |
Onychophagia | 22.72 | 14.64 | 5 | 9009 | 64 | 31688266 |
Maternal drugs affecting foetus | 22.61 | 14.64 | 14 | 9000 | 3889 | 31684441 |
Pneumonia mycoplasmal | 22.53 | 14.64 | 8 | 9006 | 626 | 31687704 |
Oculogyric crisis | 22.27 | 14.64 | 10 | 9004 | 1445 | 31686885 |
Febrile neutropenia | 22.07 | 14.64 | 4 | 9010 | 121845 | 31566485 |
Learning disorder | 21.91 | 14.64 | 9 | 9005 | 1047 | 31687283 |
Tricuspid valve disease | 21.53 | 14.64 | 6 | 9008 | 211 | 31688119 |
Ototoxicity | 20.46 | 14.64 | 10 | 9004 | 1748 | 31686582 |
Respiratory acidosis | 20.33 | 14.64 | 14 | 9000 | 4648 | 31683682 |
Sepsis neonatal | 20.25 | 14.64 | 6 | 9008 | 263 | 31688067 |
Myasthenia gravis crisis | 19.87 | 14.64 | 7 | 9007 | 535 | 31687795 |
Vasculitic rash | 19.80 | 14.64 | 8 | 9006 | 892 | 31687438 |
Torsade de pointes | 19.65 | 14.64 | 16 | 8998 | 6834 | 31681496 |
Hepatic necrosis | 18.38 | 14.64 | 12 | 9002 | 3651 | 31684679 |
Potentiating drug interaction | 18.29 | 14.64 | 13 | 9001 | 4540 | 31683790 |
Ischaemic hepatitis | 18.28 | 14.64 | 9 | 9005 | 1598 | 31686732 |
Pathogen resistance | 18.25 | 14.64 | 17 | 8997 | 8684 | 31679646 |
Swelling face | 17.87 | 14.64 | 26 | 8988 | 21364 | 31666966 |
Myoglobinuria | 17.81 | 14.64 | 7 | 9007 | 726 | 31687604 |
Accidental exposure to product | 17.72 | 14.64 | 19 | 8995 | 11476 | 31676854 |
Cardio-respiratory arrest neonatal | 17.34 | 14.64 | 3 | 9011 | 9 | 31688321 |
Neonatal disorder | 17.17 | 14.64 | 7 | 9007 | 799 | 31687531 |
Folliculitis | 17.02 | 14.64 | 12 | 9002 | 4136 | 31684194 |
Hepatic failure | 16.87 | 14.64 | 32 | 8982 | 32670 | 31655660 |
Measles | 16.73 | 14.64 | 5 | 9009 | 226 | 31688104 |
Exposure during pregnancy | 16.51 | 14.64 | 16 | 8998 | 8582 | 31679748 |
Proteus infection | 16.13 | 14.64 | 7 | 9007 | 933 | 31687397 |
Stevens-Johnson syndrome | 15.82 | 14.64 | 22 | 8992 | 17350 | 31670980 |
Brain herniation | 15.67 | 14.64 | 11 | 9003 | 3766 | 31684564 |
Megacolon | 15.20 | 14.64 | 8 | 9006 | 1634 | 31686696 |
Pupillary disorder | 15.05 | 14.64 | 5 | 9009 | 320 | 31688010 |
Visual acuity reduced | 14.83 | 14.64 | 20 | 8994 | 15323 | 31673007 |
Mycoplasma infection | 14.71 | 14.64 | 5 | 9009 | 343 | 31687987 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 3384.25 | 11.89 | 1704 | 23628 | 260755 | 70642357 |
International normalised ratio fluctuation | 231.27 | 11.89 | 73 | 25259 | 3146 | 70899966 |
Bloody discharge | 179.08 | 11.89 | 52 | 25280 | 1681 | 70901431 |
Lyme disease | 141.24 | 11.89 | 49 | 25283 | 2840 | 70900272 |
Drug interaction | 104.35 | 11.89 | 336 | 24996 | 381105 | 70522007 |
Product packaging issue | 76.65 | 11.89 | 24 | 25308 | 1006 | 70902106 |
Seronegative arthritis | 67.62 | 11.89 | 30 | 25302 | 3349 | 70899763 |
Toxic epidermal necrolysis | 64.40 | 11.89 | 75 | 25257 | 39482 | 70863630 |
Necrosis ischaemic | 60.79 | 11.89 | 20 | 25312 | 984 | 70902128 |
Hyphaema | 60.51 | 11.89 | 19 | 25313 | 804 | 70902308 |
Beta haemolytic streptococcal infection | 51.06 | 11.89 | 21 | 25311 | 1946 | 70901166 |
Pneumonia streptococcal | 49.54 | 11.89 | 22 | 25310 | 2461 | 70900651 |
Ototoxicity | 49.05 | 11.89 | 23 | 25309 | 2918 | 70900194 |
Dislocation of vertebra | 45.92 | 11.89 | 26 | 25306 | 4874 | 70898238 |
Exposure during pregnancy | 45.18 | 11.89 | 98 | 25234 | 87619 | 70815493 |
Anaphylactic reaction | 44.75 | 11.89 | 89 | 25243 | 74885 | 70828227 |
Maternal exposure during pregnancy | 44.36 | 11.89 | 115 | 25217 | 115230 | 70787882 |
Stevens-Johnson syndrome | 43.91 | 11.89 | 59 | 25273 | 35848 | 70867264 |
Wheezing | 43.78 | 11.89 | 101 | 25231 | 94069 | 70809043 |
Drug abuse | 38.33 | 11.89 | 4 | 25328 | 147252 | 70755860 |
Abortion spontaneous | 37.85 | 11.89 | 47 | 25285 | 26432 | 70876680 |
Drug intolerance | 36.88 | 11.89 | 169 | 25163 | 225518 | 70677594 |
Febrile neutropenia | 35.93 | 11.89 | 14 | 25318 | 204304 | 70698808 |
Pneumococcal infection | 35.62 | 11.89 | 13 | 25319 | 873 | 70902239 |
Acute generalised exanthematous pustulosis | 35.29 | 11.89 | 35 | 25297 | 15362 | 70887750 |
Mass excision | 34.26 | 11.89 | 10 | 25322 | 329 | 70902783 |
Death | 34.12 | 11.89 | 83 | 25249 | 509978 | 70393134 |
Completed suicide | 33.19 | 11.89 | 20 | 25312 | 227115 | 70675997 |
Infection | 32.35 | 11.89 | 155 | 25177 | 210630 | 70692482 |
Stupor | 32.05 | 11.89 | 23 | 25309 | 6486 | 70896626 |
Caesarean section | 31.57 | 11.89 | 29 | 25303 | 11578 | 70891534 |
Vertigo positional | 30.89 | 11.89 | 17 | 25315 | 3016 | 70900096 |
Tarsal tunnel syndrome | 30.34 | 11.89 | 10 | 25322 | 495 | 70902617 |
Purpura senile | 30.22 | 11.89 | 10 | 25322 | 501 | 70902611 |
Therapeutic product effect incomplete | 29.43 | 11.89 | 102 | 25230 | 119780 | 70783332 |
Intraocular pressure increased | 27.70 | 11.89 | 24 | 25308 | 8877 | 70894235 |
Drug tolerance decreased | 27.59 | 11.89 | 25 | 25307 | 9808 | 70893304 |
Lip swelling | 27.38 | 11.89 | 46 | 25286 | 34008 | 70869104 |
Torsade de pointes | 27.25 | 11.89 | 33 | 25299 | 18083 | 70885029 |
Coagulation time prolonged | 27.09 | 11.89 | 14 | 25318 | 2190 | 70900922 |
Spinal fusion surgery | 26.55 | 11.89 | 17 | 25315 | 3980 | 70899132 |
Rash | 26.20 | 11.89 | 288 | 25044 | 510274 | 70392838 |
Vomiting | 25.77 | 11.89 | 324 | 25008 | 592787 | 70310325 |
Learning disorder | 25.54 | 11.89 | 9 | 25323 | 546 | 70902566 |
Deafness bilateral | 25.46 | 11.89 | 13 | 25319 | 1983 | 70901129 |
Serum sickness-like reaction | 25.28 | 11.89 | 9 | 25323 | 563 | 70902549 |
Wound infection | 24.85 | 11.89 | 31 | 25301 | 17511 | 70885601 |
Respiratory acidosis | 24.74 | 11.89 | 24 | 25308 | 10257 | 70892855 |
Oligohydramnios | 24.59 | 11.89 | 15 | 25317 | 3225 | 70899887 |
Spondylitis | 23.70 | 11.89 | 15 | 25317 | 3442 | 70899670 |
Product dispensing error | 23.37 | 11.89 | 25 | 25307 | 11983 | 70891129 |
Adjustment disorder with depressed mood | 23.30 | 11.89 | 16 | 25316 | 4207 | 70898905 |
Ergot poisoning | 22.69 | 11.89 | 6 | 25326 | 136 | 70902976 |
Bronchial obstruction | 22.57 | 11.89 | 13 | 25319 | 2517 | 70900595 |
Rhabdomyolysis | 22.23 | 11.89 | 80 | 25252 | 95680 | 70807432 |
Corneal neovascularisation | 22.06 | 11.89 | 6 | 25326 | 152 | 70902960 |
Premature rupture of membranes | 22.05 | 11.89 | 15 | 25317 | 3883 | 70899229 |
Malignant neoplasm progression | 21.96 | 11.89 | 8 | 25324 | 121731 | 70781381 |
Oculogyric crisis | 21.79 | 11.89 | 13 | 25319 | 2685 | 70900427 |
Ulcerative keratitis | 21.72 | 11.89 | 14 | 25318 | 3313 | 70899799 |
Anaemia | 21.55 | 11.89 | 73 | 25259 | 403350 | 70499762 |
Pharyngeal oedema | 21.06 | 11.89 | 27 | 25305 | 15669 | 70887443 |
Eye pain | 20.96 | 11.89 | 41 | 25291 | 34061 | 70869051 |
Impaired gastric emptying | 20.74 | 11.89 | 21 | 25311 | 9445 | 70893667 |
Resorption bone increased | 20.56 | 11.89 | 10 | 25322 | 1375 | 70901737 |
SAPHO syndrome | 20.01 | 11.89 | 6 | 25326 | 217 | 70902895 |
Fall | 18.87 | 11.89 | 88 | 25244 | 444008 | 70459104 |
Swelling face | 18.42 | 11.89 | 57 | 25275 | 63107 | 70840005 |
Dystonia | 17.71 | 11.89 | 28 | 25304 | 19678 | 70883434 |
Haemoglobin decreased | 17.43 | 11.89 | 29 | 25303 | 205130 | 70697982 |
Breast cancer stage III | 16.84 | 11.89 | 16 | 25316 | 6665 | 70896447 |
Hypotension | 16.66 | 11.89 | 81 | 25251 | 404300 | 70498812 |
Tricuspid valve disease | 16.54 | 11.89 | 6 | 25326 | 396 | 70902716 |
Abdominal pain upper | 16.47 | 11.89 | 122 | 25210 | 193480 | 70709632 |
Asthenia | 15.93 | 11.89 | 97 | 25235 | 457569 | 70445543 |
Live birth | 15.87 | 11.89 | 22 | 25310 | 13757 | 70889355 |
Urticaria | 15.77 | 11.89 | 106 | 25226 | 162943 | 70740169 |
Vestibular disorder | 15.74 | 11.89 | 10 | 25322 | 2310 | 70900802 |
Keratitis | 15.64 | 11.89 | 12 | 25320 | 3745 | 70899367 |
Corneal deposits | 15.63 | 11.89 | 6 | 25326 | 464 | 70902648 |
Amniotic cavity infection | 15.57 | 11.89 | 7 | 25325 | 806 | 70902306 |
Anal candidiasis | 15.28 | 11.89 | 3 | 25329 | 16 | 70903096 |
Benign laryngeal neoplasm | 14.98 | 11.89 | 3 | 25329 | 18 | 70903094 |
Premature delivery | 14.81 | 11.89 | 27 | 25305 | 21277 | 70881835 |
Neutropenia | 14.78 | 11.89 | 45 | 25287 | 257111 | 70646001 |
Pneumonia mycoplasmal | 14.57 | 11.89 | 8 | 25324 | 1413 | 70901699 |
Walking aid user | 14.46 | 11.89 | 16 | 25316 | 7965 | 70895147 |
Bronchitis | 14.35 | 11.89 | 81 | 25251 | 117162 | 70785950 |
Abdominal rigidity | 14.29 | 11.89 | 10 | 25322 | 2711 | 70900401 |
Myasthenia gravis crisis | 14.18 | 11.89 | 7 | 25325 | 994 | 70902118 |
Potentiating drug interaction | 14.16 | 11.89 | 16 | 25316 | 8148 | 70894964 |
Myoglobinuria | 13.96 | 11.89 | 7 | 25325 | 1028 | 70902084 |
Starvation ketoacidosis | 13.66 | 11.89 | 4 | 25328 | 133 | 70902979 |
Cardiac arrest neonatal | 13.63 | 11.89 | 3 | 25329 | 30 | 70903082 |
Pathogen resistance | 13.53 | 11.89 | 20 | 25312 | 13259 | 70889853 |
Confusional state | 13.50 | 11.89 | 54 | 25278 | 284344 | 70618768 |
Nodule | 13.50 | 11.89 | 25 | 25307 | 19944 | 70883168 |
Maternal drugs affecting foetus | 13.48 | 11.89 | 8 | 25324 | 1636 | 70901476 |
Corneal perforation | 13.08 | 11.89 | 6 | 25326 | 724 | 70902388 |
Type 2 diabetes mellitus | 13.05 | 11.89 | 40 | 25292 | 44040 | 70859072 |
Brain oedema | 13.01 | 11.89 | 27 | 25305 | 23391 | 70879721 |
Pain | 12.96 | 11.89 | 153 | 25179 | 628663 | 70274449 |
Dermatitis allergic | 12.95 | 11.89 | 22 | 25310 | 16409 | 70886703 |
Toxicity to various agents | 12.77 | 11.89 | 82 | 25250 | 382090 | 70521022 |
Platelet count decreased | 12.68 | 11.89 | 28 | 25304 | 178194 | 70724918 |
Blood glucose increased | 12.52 | 11.89 | 11 | 25321 | 102971 | 70800141 |
Ischaemic hepatitis | 12.49 | 11.89 | 10 | 25322 | 3319 | 70899793 |
Clostridium colitis | 12.48 | 11.89 | 9 | 25323 | 2557 | 70900555 |
Stomatitis | 12.03 | 11.89 | 17 | 25315 | 128494 | 70774618 |
Documented hypersensitivity to administered product | 12.02 | 11.89 | 6 | 25326 | 873 | 70902239 |
Nasopharyngitis | 11.99 | 11.89 | 40 | 25292 | 222166 | 70680946 |
Vasculitic rash | 11.95 | 11.89 | 8 | 25324 | 2018 | 70901094 |
None
Source | Code | Description |
---|---|---|
ATC | D10AF02 | DERMATOLOGICALS ANTI-ACNE PREPARATIONS ANTI-ACNE PREPARATIONS FOR TOPICAL USE Antiinfectives for treatment of acne |
ATC | D10AF52 | DERMATOLOGICALS ANTI-ACNE PREPARATIONS ANTI-ACNE PREPARATIONS FOR TOPICAL USE Antiinfectives for treatment of acne |
ATC | J01FA01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS Macrolides |
ATC | S01AA17 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics |
FDA CS | M0028311 | Macrolides |
FDA PE | N0000009982 | Decreased Sebaceous Gland Activity |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D011500 | Protein Synthesis Inhibitors |
FDA EPC | N0000175877 | Macrolide |
FDA EPC | N0000175935 | Macrolide Antimicrobial |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Acute otitis media | indication | 3110003 | |
Listeriosis | indication | 4241002 | DOID:11573 |
Gonorrhea | indication | 15628003 | DOID:7551 |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Acute gonococcal cervicitis | indication | 20943002 | DOID:10615 |
Pertussis | indication | 27836007 | |
Acute gonococcal urethritis | indication | 29864006 | |
Neonatal conjunctivitis | indication | 34298002 | DOID:9699 |
Gonorrhea of rectum | indication | 42746002 | |
Pneumonia due to Mycoplasma pneumoniae | indication | 46970008 | |
Bacterial pneumonia | indication | 53084003 | DOID:874 |
Acute gonococcal endometritis | indication | 65295003 | DOID:7527 |
Acute bacterial sinusitis | indication | 75498004 | |
Syphilis | indication | 76272004 | |
Pneumococcal pharyngitis | indication | 76651006 | |
Nongonococcal urethritis | indication | 84619001 | |
Acne vulgaris | indication | 88616000 | |
Urethritis due to Chlamydia trachomatis | indication | 179101003 | |
Chlamydial conjunctivitis | indication | 231861005 | DOID:13800 |
Pneumococcal pneumonia | indication | 233607000 | |
Chlamydial pneumonia | indication | 233609002 | |
Neonatal pneumonia | indication | 233619008 | |
Erythrasma | indication | 238418005 | DOID:4131 |
Streptococcus pyogenes infection | indication | 302809008 | |
Infective otitis media | indication | 312218008 | |
Diphtheria | indication | 397428000 | |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Recurrent Persistent Urethritis | indication | ||
Superficial Ocular Infection | indication | ||
Preoperative Bowel Preparation | indication | ||
Prevention of Bacterial Endocarditis | indication | ||
Chlamydia Cervicitis | indication | ||
Rectal Chlamydia Trachomatis Infection | indication | ||
Prevention of Neonatal Ophthalmia | indication | ||
Pneumococcal Acute Otitis Media | indication | ||
Legionnaires' Disease | indication | ||
Rheumatic Fever Prevention | indication | ||
Haemophilus Influenzae Acute Otitis Media | indication | ||
Trachoma | off-label use | 2576002 | DOID:11265 |
Inhalational anthrax | off-label use | 11389007 | |
Actinomycotic infection | off-label use | 11817007 | DOID:8478 |
Enteric campylobacteriosis | off-label use | 18081009 | |
Lyme disease | off-label use | 23502006 | DOID:11729 |
Granuloma inguinale | off-label use | 28867007 | DOID:9113 |
Sinusitis | off-label use | 36971009 | |
Erysipelas | off-label use | 44653001 | DOID:11330 |
Blepharoconjunctivitis | off-label use | 68659002 | DOID:2456 |
Cutaneous anthrax | off-label use | 84980006 | DOID:7426 |
Ecthyma | off-label use | 85791004 | |
Gastrointestinal anthrax | off-label use | 111798006 | DOID:13386 |
Bacterial conjunctivitis | off-label use | 128350005 | DOID:9700 |
Bacterial infection of skin | off-label use | 128936008 | |
Lymphogranuloma venereum | off-label use | 186946009 | DOID:13819 |
Gastroesophageal reflux disease | off-label use | 235595009 | DOID:8534 |
Gastroparesis | off-label use | 235675006 | |
Chancroid | off-label use | 266143009 | DOID:13778 |
Meibomianitis | off-label use | 309779001 | |
Infective blepharitis | off-label use | 312219000 | |
Bacterial keratitis | off-label use | 314557000 | |
Erysipeloid | off-label use | 400105005 | |
Anthrax | off-label use | 409498004 | DOID:7427 |
Relapsing fever | off-label use | 420079008 | DOID:13034 |
Gastroscopy Adjunct | off-label use | ||
Listeria Monocytogenes Septicemia | off-label use | ||
Ureaplasma Pneumonia | off-label use | ||
Torsades de pointes | contraindication | 31722008 | |
Third trimester pregnancy | contraindication | 41587001 | |
Megaloblastic anemia due to folate deficiency | contraindication | 85649008 | DOID:14026 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Cholestatic hepatitis | contraindication | 95556007 | |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Prolonged QT interval | contraindication | 111975006 | |
Hearing disorder | contraindication | 128540005 | |
Liver function tests abnormal | contraindication | 166603001 | |
Disease of blood AND/OR blood-forming organ | contraindication | 191124002 | DOID:74 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Erythroderma | contraindication | 399992009 | |
Porphyria | contraindication | 418470004 | |
Congenital long QT syndrome | contraindication | 442917000 | |
Inflammatory dermatosis | contraindication | 703938007 |
Species | Use | Relation |
---|---|---|
Cats | Bacterial pneumonia | Indication |
Cats | Upper respiratory infections | Indication |
Cats | Secondary infections associated with panleukopenia | Indication |
Cats | Bacterial wound infections caused by Staphylococcus species | Indication |
Cats | Bacterial wound infections caused by Streptococcus species | Indication |
Cattle | Bovine respiratory disease (BRD) associated with Pasturella multiocida | Indication |
Cattle | Mastitis caused by Staphylococcus aureus | Indication |
Cattle | Mastitis caused by Streptococcus dysgalactiae | Indication |
Cattle | Mastitis caused by Streptococcus dysgalactiae | Indication |
Cattle | Mastitis caused by Streptococcus uberis | Indication |
Chickens | Prevention and reduction of lesions and in lowering severity of chronic respiratory disease | Indication |
Chickens | Prevention of infectious coryza | Indication |
Chickens | Prevention of chronic respiratory disease during periods of stress | Indication |
Chickens | Chronic respiratory disease caused by Mycoplasma gallisepticum | Indication |
Chickens | Infectious coryza caused by Hemophilus gallinarum | Indication |
Dogs | Bacterial pneumonia | Indication |
Dogs | upper respiratory infections | Indication |
Dogs | Endometritis and metritis | Indication |
Dogs | Bacterial wound infections caused by Staphylococcus species | Indication |
Dogs | Bacterial wound infections caused by Streptococcus species | Indication |
Dogs | Bacterial wound infections caused by Corynebacterium species | Indication |
Turkeys | Chronic respiratory disease during periods of stress | Indication |
Turkeys | Prevention and reduction of lesions and in lowering severity of chronic respiratory disease | Indication |
Turkeys | Control of blue comb (nonspecific infectious enteritis) | Indication |
Product | Applicant | Ingredients |
---|---|---|
Gallimycin-100P | Bimeda Animal Health Limited | 1 |
Erythro - 100, 200, Gallimycin-100 | Bimeda Animal Health Limited | 1 |
Gallimycin PFC | Bimeda Animal Health Limited | 1 |
Erythro-36 Dry, Gallimycin-36 Dry | Bimeda Animal Health Limited | 1 |
Gallimycin-36 Sterile | Bimeda Animal Health Limited | 1 |
Erythromast 36 | Zoetis Inc. | 1 |
Erythro-100 Injection | Bimeda Animal Health Limited | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.65 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
250MG | ERYTHROMYCIN | TORRENT | A211975 | July 26, 2021 | RX | TABLET, DELAYED RELEASE | ORAL | April 2, 2022 | COMPETITIVE GENERIC THERAPY |
500MG | ERYTHROMYCIN | TORRENT | A211975 | July 26, 2021 | RX | TABLET, DELAYED RELEASE | ORAL | April 2, 2022 | COMPETITIVE GENERIC THERAPY |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 7.41 | CHEMBL | |||||
Aldehyde oxidase | Enzyme | IC50 | 4.82 | WOMBAT-PK | |||||
Bile salt export pump | Transporter | IC50 | 5.39 | CHEMBL | |||||
Motilin receptor | GPCR | Ki | 4.43 | CHEMBL | |||||
Cytochrome P450 1B1 | Enzyme | IC50 | 4.40 | CHEMBL |
ID | Source |
---|---|
4017594 | VUID |
N0000145975 | NUI |
D00140 | KEGG_DRUG |
23067-13-2 | SECONDARY_CAS_RN |
3847-29-8 | SECONDARY_CAS_RN |
643-22-1 | SECONDARY_CAS_RN |
4017591 | VANDF |
4017594 | VANDF |
4017595 | VANDF |
4017596 | VANDF |
C0014806 | UMLSCUI |
CHEBI:42355 | CHEBI |
ERY | PDB_CHEM_ID |
CHEMBL2110577 | ChEMBL_ID |
CHEMBL1200506 | ChEMBL_ID |
CHEMBL532 | ChEMBL_ID |
CHEMBL3545060 | ChEMBL_ID |
CHEMBL1200510 | ChEMBL_ID |
D004917 | MESH_DESCRIPTOR_UI |
DB00199 | DRUGBANK_ID |
C010948 | MESH_SUPPLEMENTAL_RECORD_UI |
C011462 | MESH_SUPPLEMENTAL_RECORD_UI |
1456 | IUPHAR_LIGAND_ID |
C025000 | MESH_SUPPLEMENTAL_RECORD_UI |
39 | INN_ID |
63937KV33D | UNII |
12560 | PUBCHEM_CID |
24346 | RXNORM |
33316 | MMSL |
3627 | MMSL |
4675 | MMSL |
4678 | MMSL |
4679 | MMSL |
4680 | MMSL |
4769 | MMSL |
4799 | MMSL |
72164 | MMSL |
d00046 | MMSL |
002755 | NDDF |
002758 | NDDF |
002759 | NDDF |
002760 | NDDF |
30427009 | SNOMEDCT_US |
372694001 | SNOMEDCT_US |
39152007 | SNOMEDCT_US |
698006 | SNOMEDCT_US |
83981000 | SNOMEDCT_US |
96032005 | SNOMEDCT_US |
96033000 | SNOMEDCT_US |
4501-00-2 | SECONDARY_CAS_RN |
7704-67-8 | SECONDARY_CAS_RN |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Erythromycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5571 | TABLET, FILM COATED | 250 mg | ORAL | ANDA | 23 sections |
Erythromycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5572 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 23 sections |
ERYGEL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-8075 | GEL | 20 mg | TOPICAL | NDA | 18 sections |
Erythromycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-8212 | GEL | 20 mg | TOPICAL | NDA authorized generic | 18 sections |
Erythromycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-7191 | OINTMENT | 5 mg | OPHTHALMIC | ANDA | 18 sections |
Erythrocin Lactobionate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6476 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 13 sections |
Erythrocin Lactobionate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6476 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 13 sections |
Erythrocin Lactobionate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6482 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | NDA | 13 sections |
Erythrocin Lactobionate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-6482 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | NDA | 13 sections |
erythromycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0574-4024 | OINTMENT | 5 mg | OPHTHALMIC | ANDA | 18 sections |
Erythrocin Stearate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-594 | TABLET, FILM COATED | 250 mg | ORAL | ANDA | 23 sections |
Erythrocin Stearate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-595 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 23 sections |
ERYTHROMYCIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-586 | TABLET, DELAYED RELEASE | 250 mg | ORAL | ANDA | 25 sections |
ERYTHROMYCIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-588 | TABLET, DELAYED RELEASE | 500 mg | ORAL | ANDA | 25 sections |
Erythromycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-606 | TABLET, COATED | 250 mg | ORAL | ANDA | 14 sections |
Erythromycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-606 | TABLET, COATED | 250 mg | ORAL | ANDA | 14 sections |
Erythromycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-607 | TABLET, COATED | 500 mg | ORAL | ANDA | 14 sections |
Erythromycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-607 | TABLET, COATED | 500 mg | ORAL | ANDA | 14 sections |
Erythromycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13985-605 | OINTMENT | 5 mg | OPHTHALMIC | ANDA | 18 sections |
Erythromycin Lactobionate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 14789-116 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 24 sections |
ERYTHROMYCIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-088 | CAPSULE, DELAYED RELEASE | 250 mg | ORAL | ANDA | 22 sections |
ERY-TAB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-089 | TABLET, DELAYED RELEASE | 333 mg | ORAL | ANDA | 27 sections |
ERYTHROMYCIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-090 | OINTMENT | 5 mg | OPHTHALMIC | ANDA | 9 sections |
ERYTHROMYCIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-091 | TABLET, FILM COATED | 250 mg | ORAL | ANDA | 17 sections |
Erythromycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-070 | OINTMENT | 5 mg | OPHTHALMIC | ANDA | 19 sections |
Erythromycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-070 | OINTMENT | 5 mg | OPHTHALMIC | ANDA | 19 sections |
Erythromycin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-173 | OINTMENT | 5 mg | OPHTHALMIC | ANDA | 15 sections |
ERYTHROMYCIN Base Filmtab | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-387 | TABLET, FILM COATED | 250 mg | ORAL | ANDA | 24 sections |
ERYTHROMYCIN Base Filmtab | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-389 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 24 sections |
ERY-TAB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-457 | TABLET, DELAYED RELEASE | 333 mg | ORAL | ANDA | 23 sections |