Interleukin-1 receptor accessory protein

Description:

Description
  • Accession: Q9NPH3
  • Swissprot: IL1AP_HUMAN
  • Organism: Homo sapiens
  • Gene: IL1RAP
  • Target class: Membrane receptor

Drug Relations:

anakinra
A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA. As IL-1 levels are elevated in patients with COVID-19, anakinra is currently being investigated for its potential to combat cytokine release syndrome (CRS) in patients with severely ill COVID-19. Bioactivity details MOA