ADVERSE REACTIONS SECTION.

ADVERSE REACTIONS. Cardiovascular Effects. In patients receiving milrinone lactate in Phase II and III clinical trials, ventricular arrhythmias were reported in 12.1%: Ventricular ectopic activity, 8.5%; nonsustained ventricular tachycardia, 2.8%; sustained ventricular tachycardia, 1% and ventricular fibrillation, 0.2% (2 patients experienced more than one type of arrhythmia). Holter recordings demonstrated that in some patients injection of milrinone lactate increased ventricular ectopy, including nonsustained ventricular tachycardia. Life-threatening arrhythmias were infrequent and when present have been associated with certain underlying factors such as preexisting arrhythmias, metabolic abnormalities (e.g. hypokalemia), abnormal digoxin levels and catheter insertion. Milrinone lactate was not shown to be arrhythmogenic in an electrophysiology study. Supraventricular arrhythmias were reported in 3.8% of the patients receiving milrinone lactate. The incidence of both supraventricular and ventricular arrhythmias has not been related to the dose or plasma milrinone concentration.Other cardiovascular adverse reactions include hypotension, 2.9% and angina/chest pain, 1.2%.In the post marketing experience, there have been rare cases of torsades de pointes reported.. CNS Effects. Headaches, usually mild to moderate in severity, have been reported in 2.9% of patients receiving milrinone lactate.. Other Effects. Other adverse reactions reported, but not definitely related to the administration of milrinone lactate include hypokalemia, 0.6%; tremor, 0.4%; and thrombocytopenia, 0.4%.Isolated spontaneous reports of bronchospasm and anaphylactic shock have been received; and in the post-marketing experience, liver function test abnormalities and skin reactions such as rash have been reported.. Post-Marketing Adverse Event Reports. In addition to adverse events reported from clinical trials, the following events have been reported from worldwide post-marketing experience with milrinone: Isolated spontaneous reports of bronchospasm and anaphylactic shock. Liver function test abnormalities and skin reactions such as rash. Administration site conditions: Infusion site reaction. To report SUSPECTED ADVERSE REACTIONS, contact Shandong New Time Pharmaceutical Co., Ltd., at 1-866-XXX-XXXX or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

CLINICAL PHARMACOLOGY SECTION.

CLINICAL PHARMACOLOGY. Milrinone lactate is positive inotrope and vasodilator, with little chronotropic activity different in structure and mode of action from either the digitalis glycosides or catecholamines.Milrinone lactate, at relevant inotropic and vasorelaxant concentrations, is selective inhibitor of peak III cAMP phosphodiesterase isozyme in cardiac and vascular muscle. This inhibitory action is consistent with cAMP mediated increases in intracellular ionized calcium and contractile force in cardiac muscle, as well as with cAMP dependent contractile protein phosphorylation and relaxation in vascular muscle. Additional experimental evidence also indicates that milrinone lactate is not beta-adrenergic agonist nor does it inhibit sodium-potassium adenosine triphosphatase activity as do the digitalis glycosides.Clinical studies in patients with congestive heart failure have shown that milrinone lactate produces dose-related and plasma drug concentration-related increases in the maximum rate of increase of left ventricular pressure. Studies in normal subjects have shown that milrinone lactate produces increases in the slope of the left ventricular pressure-dimension relationship, indicating direct inotropic effect of the drug. Milrinone lactate also produces dose-related and plasma concentration-related increases in forearm blood flow in patients with congestive heart failure, indicating direct arterial vasodilator activity of the drug.Both the inotropic and vasodilatory effects have been observed over the therapeutic range of plasma milrinone concentrations of 100 ng/mL to 300 ng/mL.In addition to increasing myocardial contractility, milrinone lactate improves diastolic function as evidenced by improvements in left ventricular diastolic relaxation.The acute administration of intravenous milrinone has also been evaluated in clinical trials in excess of 1600 patients, with chronic heart failure, heart failure associated with cardiac surgery, and heart failure associated with myocardial infarction. The total number of deaths, either on therapy or shortly thereafter (24 hours) was 15, less than 0.9%, few of which were thought to be drug-related.. PHARMACOKINETICS. Following intravenous injections of 12.5 mcg/kg to 125 mcg/kg to congestive heart failure patients, milrinone lactate had volume of distribution of 0.38 liters/kg, mean terminal elimination half-life of 2.3 hours, and clearance of 0.13 liters/kg/hr. Following intravenous infusions of 0.2 mcg/kg/min to 0.7 mcg/kg/min to congestive heart failure patients, the drug had volume of distribution of about 0.45 liters/kg, mean terminal elimination half-life of 2.4 hours, and clearance of 0.14 liters/kg/hr. These pharmacokinetic parameters were not dose-dependent, and the area under the plasma concentration versus time curve following injections was significantly dose-dependent.Milrinone lactate has been shown (by equilibrium dialysis) to be approximately 70% bound to human plasma protein.The primary route of excretion of milrinone lactate in man is via the urine. The major urinary excretions of orally administered milrinone lactate in man are milrinone (83%) and its 0-glucuronide metabolite (12%). Elimination in normal subjects via the urine is rapid, with approximately 60% recovered within the first two hours following dosing and approximately 90% recovered within the first eight hours following dosing. The mean renal clearance of milrinone lactate is approximately 0.3 liters/min, indicative of active secretion.. Pharmacodynamics. In patients with heart failure due to depressed myocardial function, milrinone lactate produced prompt dose and plasma concentration related increase in cardiac output and decreases in pulmonary capillary wedge pressure and vascular resistance, which were accompanied by mild-to-moderate increases in heart rate. Additionally, there is no increased effect on myocardial oxygen consumption. In uncontrolled studies, hemodynamic improvement during intravenous therapy with milrinone lactate was accompanied by clinical symptomatic improvement, but the ability of milrinone lactate to relieve symptoms has not been evaluated in controlled clinical trials. The great majority of patients experience improvements in hemodynamic function within to 15 minutes of the initiation of therapy.In studies in congestive heart failure patients, milrinone lactate when administered as loading injection followed by maintenance infusion produced significant mean initial increases in cardiac index of 25 percent, 38 percent, and 42 percent at dose regimens of 37.5 mcg/kg/0.375 mcg/kg/min, 50 mcg/kg/0.5 mcg/kg/min, and 75 mcg/kg/0.75 mcg/kg/min, respectively. Over the same range of loading injections and maintenance infusions, pulmonary capillary wedge pressure significantly decreased by 20 percent, 23 percent, and 36 percent, respectively, while systemic vascular resistance significantly decreased by 17 percent, 21 percent, and 37 percent. Mean arterial pressure fell by up to percent at the two lower dose regimens, but by 17 percent at the highest dose. Patients evaluated for 48 hours maintained improvements in hemodynamic function, with no evidence of diminished response (tachyphylaxis). smaller number of patients have received infusions of milrinone lactate for periods up to 72 hours without evidence of tachyphylaxis.The duration of therapy should depend upon patient responsiveness.Milrinone lactate has favorable inotropic effect in fully digitalized patients without causing signs of glycoside toxicity. Theoretically, in cases of atrial flutter/fibrillation, it is possible that milrinone lactate may increase ventricular response rate because of its slight enhancement of AV node conduction. In these cases, digitalis should be considered prior to the institution of therapy with milrinone lactate.Improvement in left ventricular function in patients with ischemic heart disease has been observed. The improvement has occurred without inducing symptoms or electrocardiographic signs of myocardial ischemia.The steady-state plasma milrinone concentrations after approximately to 12 hours of unchanging maintenance infusion of 0.5 mcg/kg/min are approximately 200 ng/mL. Near maximum favorable effects of milrinone lactate on cardiac output and pulmonary capillary wedge pressure are seen at plasma milrinone concentrations in the 150 ng/mL to 250 ng/mL range.

CONTRAINDICATIONS SECTION.

CONTRAINDICATIONS. Milrinone Lactate Injection is contraindicated in patients who are hypersensitive to it.

DESCRIPTION SECTION.

DESCRIPTION. Milrinone lactate injection is member of class of bipyridine inotropic/vasodilator agents with phosphodiesterase inhibitor activity, distinct from digitalis glycosides or catecholamines. Milrinone lactate is designated chemically as 1,6-dihydro-2-methyl-6-oxo-[3,4-bipyridine]-5-carbonitrile lactate and has the following structure:Milrinone is an off-white to tan crystalline compound with molecular weight of 211.2 and an empirical formula of 12H 9N 3O. It is slightly soluble in methanol, and very slightly soluble in chloroform and in water. As the lactate salt, it is stable and colorless to pale yellow in solution. Milrinone lactate is available as sterile aqueous solutions of the lactate salt of milrinone for injection or infusion intravenously. Sterile, single-dose vials: Single-dose vials of 10 and 20 mL contain in each mL milrinone lactate equivalent to mg milrinone and 47 mg Dextrose, Anhydrous, USP, in Water for Injection, USP. The pH is adjusted to between 3.2 and 4.0 with lactic acid or sodium hydroxide. The total concentration of lactic acid can vary between 0.95 mg/mL and 1.29 mg/mL. These vials require preparation of dilutions prior to administration to patients intravenously. structure.

DOSAGE & ADMINISTRATION SECTION.

DOSAGE AND ADMINISTRATION. Milrinone Lactate Injection, USP should be administered with loading dose followed by continuous infusion (maintenance dose) according to the following guidelines:LOADING DOSE50 mcg/kg: Administer slowly over 10 minutesThe table below shows the loading dose in milliliters (mL) of milrinone lactate (1mg/mL) by patient body weight (kg). Loading Dose (mL) Using mg/mL Concentration Patient Body Weight (kg) kg 30 4050 60 70 80 90 100 110 120 mL 1.5 2.5 3.5 4.5 5.5 6The loading dose may be given undiluted, but diluting to rounded total volume of 10 or 20 mL (see Maintenance Dose for diluents) may simplify the visualization of the injection rate.MAINTENANCE DOSE Infusion Rate Total Daily Dose (24 Hours) Minimum 0.375 mcg/kg/min 0.59 mg/kg Administer as continuous intravenous infusion Standard 0.5 mcg/kg/min 0.77 mg/kg Maximum 0.75 mcg/kg/min 1.13 mg/kgMilrinone lactate drawn from vials should be diluted prior to maintenance dose administration. The diluents that may be used are 0.45% Sodium Chloride Injection USP, 0.9% Sodium Chloride Injection USP, or 5% Dextrose Injection USP. The table below shows the volume of diluent in milliliters (mL) that must be used to achieve 200 mcg/mL concentration for infusion, and the resultant total volumes. Desired Infusion Concentration mcg/mL Milrinone Lactate Injection mg/mL (mL) Diluent (mL) Total Volume (mL) 200 10 40 50 200 20 80 100The infusion rate should be adjusted according to hemodynamic and clinical response. Patients should be closely monitored. In controlled clinical studies, most patients showed an improvement in hemodynamic status as evidenced by increases in cardiac output and reductions in pulmonary capillary wedge pressure.Note: See Dosage Adjustment in Renally Impaired Patients. Dosage may be titrated to the maximum hemodynamic effect and should not exceed 1.13 mg/kg/day. Duration of therapy should depend upon patient responsiveness. The maintenance dose in mL/hr by patient body weight (kg) may be determined by reference to the following table.Milrinone Infusion Rate (mL/hr) Using 200 mcg/mL Concentration Maintenance Dose (mcg/kg/min) Patient Body Weight (kg) 30 40 50 60 70 80 90 100 110 120 0.375 3.4 4.5 5.6 6.8 7.9 10.1 11.3 12.4 13.5 0.4 3.6 4.8 7.2 8.4 9.6 10.8 12 13.2 14.4 0.5 4.5 7.5 10.5 12 13.5 15 16.5 18 0.6 5.4 7.2 10.8 12.6 14.4 16.2 18 19.8 21.6 0.7 6.3 8.4 10.5 12.6 14.7 16.8 18.9 21 23.1 25.2 0.75 6.8 11.3 13.5 15.8 18 20.3 22.5 24.8 27When administering milrinone lactate by continuous infusion, it is advisable to use calibrated electronic infusion device.Intravenous drug products should be inspected visually and should not be used if particulate matter or discoloration is present.. Dosage Adjustment in Renally Impaired Patients. Data obtained from patients with severe renal impairment (creatinine clearance 0 to 30 mL/min) but without congestive heart failure have demonstrated that the presence of renal impairment significantly increases the terminal elimination half-life of milrinone lactate. Reductions in infusion rate may be necessary in patients with renal impairment. For patients with clinical evidence of renal impairment, the recommended infusion rate can be obtained from the following table: Creatinine Clearance (mL/min/1.73m 2) Infusion Rate (mcg/kg/min) 0.210 0.23 20 0.28 30 0.33 40 0.38 50 0.43.

HOW SUPPLIED SECTION.

HOW SUPPLIED. Milrinone Lactate Injection, USP is supplied as 10 mL single-dose vials in box of 10, NDC 42677-313-10; as 20 mL single-dose vials box of 10, NDC 42677-314-10, containing sterile, clear, colorless to pale yellow solution. Each mL contains milrinone lactate equivalent to mg milrinone.Store at 20 to 25C (68 to 77F) [See USP Controlled Room Temperature]. Avoid freezing.Discard unused portion.Manufactured by: Shandong New Time Pharmaceutical Co., Ltd., No. 1, North Outer Ring Road, Feixian, Shandong 273400, China. Revised: 08/2022 LBL 128.

INDICATIONS & USAGE SECTION.

INDICATIONS AND USAGE. Milrinone Lactate Injection is indicated for the short-term intravenous treatment of patients with acute decompensated heart failure. Patients receiving milrinone lactate should be observed closely with appropriate electrocardiographic equipment. The facility for immediate treatment of potential cardiac events, which may include life threatening ventricular arrhythmias, must be available. The majority of experience with intravenous milrinone lactate has been in patients receiving digoxin and diuretics.

OVERDOSAGE SECTION.

OVERDOSAGE. Doses of milrinone lactate may produce hypotension because of its vasodilator effect. If this occurs, administration of milrinone lactate should be reduced or temporarily discontinued until the patients condition stabilizes. No specific antidote is known, but general measures for circulatory support should be taken.

PACKAGE LABEL.PRINCIPAL DISPLAY PANEL.

PRINCIPAL DISPLAY PANEL -10 mL Vial Container and Carton. 10 mL Vial ContainerMilrinone Lactate Injection10 mg/ 10 mL (1 mg/mL)NDC 42677-313-01Rx onlyFor Intravenous Use Only10 mL Vial CartonMilrinone Lactate Injection10 mg/ 10 mL (1 mg/mL)NDC 42677-313-10Rx onlyFor Intravenous Use Only. container10ml. carton10ml.

PRECAUTIONS SECTION.

PRECAUTIONS. General. Milrinone lactate should not be used in patients with severe obstructive aortic or pulmonic valvular disease in lieu of surgical relief of the obstruction. Like other inotropic agents, it may aggravate outflow tract obstruction in hypertrophic subaortic stenosis.Supraventricular and ventricular arrhythmias have been observed in the high-risk population treated. In some patients, injections of milrinone lactate and oral milrinone lactate have been shown to increase ventricular ectopy, including nonsustained ventricular tachycardia. The potential for arrhythmia, present in congestive heart failure itself, may be increased by many drugs or combinations of drugs. Patients receiving milrinone lactate should be closely monitored during infusion.Milrinone lactate produces slight shortening of AV node conduction time, indicating potential for an increased ventricular response rate in patients with atrial flutter/fibrillation which is not controlled with digitalis therapy.During therapy with milrinone lactate, blood pressure and heart rate should be monitored and the rate of infusion slowed or stopped in patients showing excessive decreases in blood pressure.If prior vigorous diuretic therapy is suspected to have caused significant decreases in cardiac filling pressure, milrinone lactate should be cautiously administered with monitoring of blood pressure, heart rate, and clinical symptomatology.There is no experience in controlled trials with infusions of milrinone for periods exceeding 48 hours. Cases of infusion site reaction have been reported with intravenous milrinone therapy (see ADVERSE REACTIONS). Consequently, careful monitoring of the infusion site should be maintained to avoid possible extravasation. Use in Acute Myocardial Infarction. No clinical studies have been conducted in patients in the acute phase of post myocardial infarction. Until further clinical experience with this class of drugs is gained, milrinone lactate is not recommended in these patients.. Laboratory Tests. Fluid and Electrolytes: Fluid and electrolyte changes and renal function should be carefully monitored during therapy with milrinone lactate. Improvement in cardiac output with resultant diuresis may necessitate reduction in the dose of diuretic. Potassium loss due to excessive diuresis may predispose digitalized patients to arrhythmias. Therefore, hypokalemia should be corrected by potassium supplementation in advance of or during use of milrinone lactate.. Drug Interactions. No untoward clinical manifestations have been observed in limited experience with patients in whom milrinone lactate was used concurrently with the following drugs: digitalis glycosides; lidocaine, quinidine; hydralazine, prazosin; isosorbide dinitrate, nitroglycerin; chlorthalidone, furosemide, hydrochlorothiazide, spironolactone; captopril; heparin, warfarin, diazepam, insulin; and potassium supplements.. Chemical Interactions. There is an immediate chemical interaction which is evidenced by the formation of precipitate when furosemide is injected into an intravenous line of an infusion of milrinone lactate. Therefore, furosemide should not be administered in intravenous lines containing milrinone lactate.. Carcinogenesis, Mutagenesis, Impairment of Fertility. Twenty-four months of oral administration of milrinone lactate to mice at doses up to 40 mg/kg/day (about 50 times the human oral therapeutic dose in 50 kg patient) was unassociated with evidence of carcinogenic potential. Neither was there evidence of carcinogenic potential when milrinone lactate was orally administered to rats at doses up to mg/kg/day (about times the human oral therapeutic dose) for twenty-four months or at 25 mg/kg/day (about 30 times the human oral therapeutic dose) for up to 18 months in males and 20 months in females. Whereas the Chinese Hamster Ovary Chromosome Aberration Assay was positive in the presence of metabolic activation system, results from the Ames Test, the Mouse Lymphoma Assay, the Micronucleus Test, and the in vivo Rat Bone Marrow Metaphase Analysis indicated an absence of mutagenic potential. In reproductive performance studies in rats, milrinone lactate had no effect on male or female fertility at oral doses up to 32 mg/kg/day.. Animal Toxicity. Oral and intravenous administration of toxic dosages of milrinone lactate to rats and dogs resulted in myocardial degeneration/fibrosis and endocardial hemorrhage, principally affecting the left ventricular papillary muscles. Coronary vascular lesions characterized by periarterial edema and inflammation have been observed in dogs only. The myocardial/endocardial changes are similar to those produced by beta-adrenergic receptor agonists such as isoproterenol, while the vascular changes are similar to those produced by minoxidil and hydralazine. Doses within the recommended clinical dose range (up to 1.13 mg/kg/day) for congestive heart failure patients have not produced significant adverse effects in animals.. Pregnancy. Oral administration of milrinone lactate to pregnant rats and rabbits during organogenesis produced no evidence of teratogenicity at dose levels up to 40 mg/kg/day and 12 mg/kg/day, respectively. Milrinone lactate did not appear to be teratogenic when administered intravenously to pregnant rats at doses up to mg/kg/day (about 2.5 times the maximum recommended clinical intravenous dose) or pregnant rabbits at doses up to 12 mg/kg/day, although an increased resorption rate was apparent at both mg/kg/day and 12 mg/kg/day (intravenous) in the latter species. There are no adequate and well-controlled studies in pregnant women. Milrinone lactate should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.. Nursing Mothers. Caution should be exercised when milrinone lactate is administered to nursing women, since it is not known whether it is excreted in human milk.. Pediatric Use. Safety and effectiveness in pediatric patients have not been established.. Use in Elderly Patients. There are no special dosage recommendations for the elderly patient. Ninety percent of all patients administered milrinone lactate in clinical studies were within the age range of 45 to 70 years, with mean age of 61 years. Patients in all age groups demonstrated clinically and statistically significant responses. No age-related effects on the incidence of adverse reactions have been observed. Controlled pharmacokinetic studies have not disclosed any age-related effects on the distribution and elimination of milrinone lactate.

SPL UNCLASSIFIED SECTION.

PHARMACOKINETICS. Following intravenous injections of 12.5 mcg/kg to 125 mcg/kg to congestive heart failure patients, milrinone lactate had volume of distribution of 0.38 liters/kg, mean terminal elimination half-life of 2.3 hours, and clearance of 0.13 liters/kg/hr. Following intravenous infusions of 0.2 mcg/kg/min to 0.7 mcg/kg/min to congestive heart failure patients, the drug had volume of distribution of about 0.45 liters/kg, mean terminal elimination half-life of 2.4 hours, and clearance of 0.14 liters/kg/hr. These pharmacokinetic parameters were not dose-dependent, and the area under the plasma concentration versus time curve following injections was significantly dose-dependent.Milrinone lactate has been shown (by equilibrium dialysis) to be approximately 70% bound to human plasma protein.The primary route of excretion of milrinone lactate in man is via the urine. The major urinary excretions of orally administered milrinone lactate in man are milrinone (83%) and its 0-glucuronide metabolite (12%). Elimination in normal subjects via the urine is rapid, with approximately 60% recovered within the first two hours following dosing and approximately 90% recovered within the first eight hours following dosing. The mean renal clearance of milrinone lactate is approximately 0.3 liters/min, indicative of active secretion.

WARNINGS SECTION.

WARNINGS. Whether given orally or by continuous or intermittent intravenous infusion, milrinone lactate has not been shown to be safe or effective in the longer (greater than 48 hours) treatment of patients with heart failure. In multicenter trial of 1088 patients with Class III and IV heart failure, long-term oral treatment with milrinone lactate was associated with no improvement in symptoms and an increased risk of hospitalization and death. In this study, patients with Class IV symptoms appeared to be at particular risk of life-threatening cardiovascular reactions. There is no evidence that milrinone lactate given by long-term continuous or intermittent infusion does not carry similar risk.The use of milrinone lactate both intravenously and orally has been associated with increased frequency of ventricular arrhythmias, including nonsustained ventricular tachycardia. Long-term oral use has been associated with an increased risk of sudden death. Hence, patients receiving milrinone lactate should be observed closely with the use of continuous electrocardiographic monitoring to allow the prompt detection and management of ventricular arrhythmias.