dipivefrine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sympathomimetic, phenethyl derivatives 922 52365-63-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dipivefrin hydrochloride
  • dipivefrin
  • dipivefrine
  • dipivefrin HCl
used in treatment of both primary & open angle glaucoma; RN given refers to (+-)-isomer
  • Molecular weight: 351.44
  • Formula: C19H29NO5
  • CLOGP: 1.57
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 84.86
  • ALOGS: -3.78
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 2, 1980 FDA ALLERGAN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01EA02 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Sympathomimetics in glaucoma therapy
FDA MoA N0000000122 Adrenergic Agonists
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D018377 Neurotransmitter Agents
CHEBI has role CHEBI:35524 sympathomimetic
CHEBI has role CHEBI:37886 adrenomimetics
CHEBI has role CHEBI:39456 antiglaucoma agent
CHEBI has role CHEBI:50266 prodrugs
CHEBI has role CHEBI:66981 ophthalmologicals
FDA EPC N0000175883 Adrenergic Receptor Agonist

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Open-angle glaucoma indication 84494001 DOID:1067
Aphakia contraindication 24010005
Angle-closure glaucoma contraindication 392291006 DOID:13550

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.72 acidic
pKa2 8.84 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-2C adrenergic receptor GPCR AGONIST WOMBAT-PK CHEMBL
Alpha-2B adrenergic receptor GPCR AGONIST WOMBAT-PK CHEMBL
Alpha-2A adrenergic receptor GPCR AGONIST WOMBAT-PK CHEMBL

External reference:

IDSource
4019152 VUID
N0000147397 NUI
D01017 KEGG_DRUG
64019-93-8 SECONDARY_CAS_RN
4019152 VANDF
4019728 VANDF
C0058415 UMLSCUI
CHEBI:4646 CHEBI
CHEMBL1201262 ChEMBL_ID
CHEMBL1200833 ChEMBL_ID
DB00449 DRUGBANK_ID
C015173 MESH_SUPPLEMENTAL_RECORD_UI
3105 PUBCHEM_CID
7166 IUPHAR_LIGAND_ID
4429 INN_ID
8Q1PVL543G UNII
203156 RXNORM
2447 MMSL
4618 MMSL
001788 NDDF
004978 NDDF
37013008 SNOMEDCT_US
372830005 SNOMEDCT_US
73647000 SNOMEDCT_US

Pharmaceutical products:

None