Stem definition | Drug id | CAS RN |
---|---|---|
sympathomimetic, phenethyl derivatives | 922 | 52365-63-6 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
May 2, 1980 | FDA | ALLERGAN |
None
None
Source | Code | Description |
---|---|---|
ATC | S01EA02 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Sympathomimetics in glaucoma therapy |
FDA MoA | N0000000122 | Adrenergic Agonists |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D000322 | Adrenergic Agonists |
MeSH PA | D018377 | Neurotransmitter Agents |
CHEBI has role | CHEBI:35524 | sympathomimetic |
CHEBI has role | CHEBI:37886 | adrenomimetics |
CHEBI has role | CHEBI:39456 | antiglaucoma agent |
CHEBI has role | CHEBI:50266 | prodrugs |
CHEBI has role | CHEBI:66981 | ophthalmologicals |
FDA EPC | N0000175883 | Adrenergic Receptor Agonist |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Open-angle glaucoma | indication | 84494001 | DOID:1067 |
Aphakia | contraindication | 24010005 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 13.72 | acidic |
pKa2 | 8.84 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Alpha-2C adrenergic receptor | GPCR | AGONIST | WOMBAT-PK | CHEMBL | |||||
Alpha-2B adrenergic receptor | GPCR | AGONIST | WOMBAT-PK | CHEMBL | |||||
Alpha-2A adrenergic receptor | GPCR | AGONIST | WOMBAT-PK | CHEMBL |
ID | Source |
---|---|
4019152 | VUID |
N0000147397 | NUI |
D01017 | KEGG_DRUG |
64019-93-8 | SECONDARY_CAS_RN |
4019152 | VANDF |
4019728 | VANDF |
C0058415 | UMLSCUI |
CHEBI:4646 | CHEBI |
CHEMBL1201262 | ChEMBL_ID |
CHEMBL1200833 | ChEMBL_ID |
DB00449 | DRUGBANK_ID |
C015173 | MESH_SUPPLEMENTAL_RECORD_UI |
3105 | PUBCHEM_CID |
7166 | IUPHAR_LIGAND_ID |
4429 | INN_ID |
8Q1PVL543G | UNII |
203156 | RXNORM |
2447 | MMSL |
4618 | MMSL |
001788 | NDDF |
004978 | NDDF |
37013008 | SNOMEDCT_US |
372830005 | SNOMEDCT_US |
73647000 | SNOMEDCT_US |
None