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clonidine ๐ถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| alpha-2 adrenoreceptor agonists | 704 | 4205-90-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.45 | mg | O |
| 0.45 | mg | P |
| 0.10 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.17 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Hosey CM, Chan R, Benet LZ |
| EoM (Fraction excreted unchanged in urine) | 62 % | Hosey CM, Chan R, Benet LZ |
| BA (Bioavailability) | 95 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 3.30 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 4 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.56 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 7.60 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 50 mg/mL | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ALK,AXL,BRAF,CAMK2B,CAMK2D,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EPHB4,ERBB2,FLT3,FYN,GRK2,ITK,JAK1,JAK2,KIT,LYN,MAP3K1,MAP3K21,MAP3K7,MAP4K1,MAPK7,MAPK9,MARK4,MTOR,NTRK2,PDK2,PDK4,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,TEK,TTK | 44 | |||
| kinase-selectivity-class | ACVR2B,AXL,BRAF,DDR1,EPHB4,ERBB2,GRK2,MAPK7,PDK4,SIK2,SIK3 | 11 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 3, 1974 | FDA | BOEHRINGER INGELHEIM |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Food allergy | 701.87 | 9.62 | 401 | 97402 | 25077 | 90505567 |
| Temperature regulation disorder | 645.19 | 9.62 | 315 | 97488 | 14264 | 90516380 |
| Immunodeficiency | 537.13 | 9.62 | 414 | 97389 | 42820 | 90487824 |
| Completed suicide | 482.62 | 9.62 | 684 | 97119 | 144374 | 90386270 |
| Hyperhidrosis | 418.76 | 9.62 | 619 | 97184 | 135686 | 90394958 |
| Upper respiratory tract infection | 374.53 | 9.62 | 569 | 97234 | 127749 | 90402895 |
| Rash erythematous | 359.58 | 9.62 | 396 | 97407 | 64708 | 90465936 |
| Overdose | 342.43 | 9.62 | 612 | 97191 | 157097 | 90373547 |
| Hypertension | 310.64 | 9.62 | 1141 | 96662 | 456391 | 90074253 |
| Coeliac disease | 282.81 | 9.62 | 292 | 97511 | 44318 | 90486326 |
| Fluid retention | 268.87 | 9.62 | 399 | 97404 | 87692 | 90442952 |
| Prescribed overdose | 258.42 | 9.62 | 414 | 97389 | 97211 | 90433433 |
| Intentional product misuse | 256.63 | 9.62 | 394 | 97409 | 89210 | 90441434 |
| Foetal death | 247.64 | 9.62 | 194 | 97609 | 20529 | 90510115 |
| Bradycardia | 180.05 | 9.62 | 324 | 97479 | 83523 | 90447121 |
| Drug withdrawal syndrome | 157.28 | 9.62 | 174 | 97629 | 28549 | 90502095 |
| Hypertensive crisis | 155.48 | 9.62 | 139 | 97664 | 17645 | 90512999 |
| Cardiac failure congestive | 144.33 | 9.62 | 325 | 97478 | 98369 | 90432275 |
| Asthma | 135.55 | 9.62 | 569 | 97234 | 241591 | 90289053 |
| Synovitis | 131.82 | 9.62 | 98 | 97705 | 329654 | 90200990 |
| Systemic lupus erythematosus | 128.14 | 9.62 | 121 | 97682 | 361775 | 90168869 |
| Mental status changes | 123.01 | 9.62 | 193 | 97610 | 44486 | 90486158 |
| Therapeutic product effect decreased | 116.84 | 9.62 | 78 | 97725 | 277493 | 90253151 |
| Neovascularisation | 115.80 | 9.62 | 49 | 97754 | 1581 | 90529063 |
| Suspected suicide | 113.07 | 9.62 | 89 | 97714 | 9479 | 90521165 |
| Lower respiratory tract infection | 108.82 | 9.62 | 68 | 97735 | 250591 | 90280053 |
| Pemphigus | 106.91 | 9.62 | 117 | 97686 | 326747 | 90203897 |
| Paradoxical drug reaction | 105.67 | 9.62 | 70 | 97733 | 5696 | 90524948 |
| Maternal exposure during pregnancy | 103.94 | 9.62 | 142 | 97661 | 359921 | 90170723 |
| Gastrointestinal disorder | 102.92 | 9.62 | 76 | 97727 | 256611 | 90274033 |
| Constipation | 102.33 | 9.62 | 583 | 97220 | 279812 | 90250832 |
| Arthropathy | 99.25 | 9.62 | 151 | 97652 | 366091 | 90164553 |
| Application site rash | 98.46 | 9.62 | 51 | 97752 | 2618 | 90528026 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 97.11 | 9.62 | 58 | 97745 | 3935 | 90526709 |
| Application site pruritus | 96.35 | 9.62 | 59 | 97744 | 4188 | 90526456 |
| Bursitis | 96.34 | 9.62 | 337 | 97466 | 131317 | 90399327 |
| Blood pressure inadequately controlled | 96.15 | 9.62 | 68 | 97735 | 6156 | 90524488 |
| Body tinea | 93.77 | 9.62 | 46 | 97757 | 2102 | 90528542 |
| Nephrogenic systemic fibrosis | 90.48 | 9.62 | 56 | 97747 | 4052 | 90526592 |
| Withdrawal syndrome | 84.99 | 9.62 | 113 | 97690 | 22411 | 90508233 |
| Product adhesion issue | 83.68 | 9.62 | 58 | 97745 | 5084 | 90525560 |
| Alopecia | 83.13 | 9.62 | 266 | 97537 | 494805 | 90035839 |
| C-reactive protein abnormal | 82.99 | 9.62 | 18 | 97785 | 127411 | 90403233 |
| Neutropenia | 82.15 | 9.62 | 73 | 97730 | 224831 | 90305813 |
| Hypotension | 81.72 | 9.62 | 616 | 97187 | 324781 | 90205863 |
| Glossodynia | 81.21 | 9.62 | 139 | 97664 | 321640 | 90209004 |
| Psoriasis | 80.13 | 9.62 | 344 | 97459 | 147410 | 90383234 |
| Ill-defined disorder | 77.71 | 9.62 | 52 | 97751 | 184839 | 90345805 |
| Toxicity to various agents | 77.46 | 9.62 | 554 | 97249 | 287292 | 90243352 |
| Inhibitory drug interaction | 77.07 | 9.62 | 46 | 97757 | 3117 | 90527527 |
| Hand deformity | 75.72 | 9.62 | 127 | 97676 | 296235 | 90234409 |
| Blood pressure increased | 74.50 | 9.62 | 414 | 97389 | 196803 | 90333841 |
| Swelling | 73.98 | 9.62 | 220 | 97583 | 418838 | 90111806 |
| Sinus bradycardia | 73.31 | 9.62 | 91 | 97712 | 16861 | 90513783 |
| Poisoning | 72.84 | 9.62 | 86 | 97717 | 15131 | 90515513 |
| Arthralgia | 72.67 | 9.62 | 517 | 97286 | 778005 | 89752639 |
| Anti-cyclic citrullinated peptide antibody positive | 72.56 | 9.62 | 89 | 97714 | 236344 | 90294300 |
| Distributive shock | 71.19 | 9.62 | 45 | 97758 | 3379 | 90527265 |
| Withdrawal hypertension | 69.46 | 9.62 | 19 | 97784 | 150 | 90530494 |
| Hypertensive encephalopathy | 68.34 | 9.62 | 27 | 97776 | 728 | 90529916 |
| Infection susceptibility increased | 67.95 | 9.62 | 46 | 97757 | 3880 | 90526764 |
| Application site erythema | 67.11 | 9.62 | 51 | 97752 | 5157 | 90525487 |
| Pericarditis | 66.06 | 9.62 | 119 | 97684 | 270032 | 90260612 |
| Cerebrovascular accident | 64.97 | 9.62 | 285 | 97518 | 123248 | 90407396 |
| Joint dislocation | 64.23 | 9.62 | 146 | 97657 | 44436 | 90486208 |
| Facet joint syndrome | 63.86 | 9.62 | 14 | 97789 | 98375 | 90432269 |
| Exposure during pregnancy | 63.04 | 9.62 | 457 | 97346 | 237953 | 90292691 |
| Back pain | 61.72 | 9.62 | 567 | 97236 | 316608 | 90214036 |
| Febrile neutropenia | 60.75 | 9.62 | 49 | 97754 | 158300 | 90372344 |
| Abdominal discomfort | 57.62 | 9.62 | 292 | 97511 | 477036 | 90053608 |
| Accidental exposure to product by child | 56.56 | 9.62 | 28 | 97775 | 1305 | 90529339 |
| Malignant neoplasm progression | 55.29 | 9.62 | 23 | 97780 | 106847 | 90423797 |
| Erythema | 55.27 | 9.62 | 430 | 97373 | 228816 | 90301828 |
| Seronegative arthritis | 53.31 | 9.62 | 81 | 97722 | 18153 | 90512491 |
| Inflammation | 52.93 | 9.62 | 69 | 97734 | 178523 | 90352121 |
| Wound | 52.76 | 9.62 | 160 | 97643 | 302820 | 90227824 |
| Hepatic enzyme increased | 52.61 | 9.62 | 608 | 97195 | 360128 | 90170516 |
| Glucose tolerance impaired | 51.90 | 9.62 | 53 | 97750 | 7932 | 90522712 |
| Application site irritation | 51.67 | 9.62 | 30 | 97773 | 1931 | 90528713 |
| Decreased immune responsiveness | 51.38 | 9.62 | 55 | 97748 | 8693 | 90521951 |
| Sedation | 50.72 | 9.62 | 140 | 97663 | 48031 | 90482613 |
| Product tampering | 50.63 | 9.62 | 19 | 97784 | 444 | 90530200 |
| Lip dry | 50.21 | 9.62 | 23 | 97780 | 100932 | 90429712 |
| Duodenal ulcer perforation | 48.45 | 9.62 | 104 | 97699 | 221184 | 90309460 |
| Cardio-respiratory arrest | 48.23 | 9.62 | 164 | 97639 | 62976 | 90467668 |
| Intentional product use issue | 46.60 | 9.62 | 103 | 97700 | 216789 | 90313855 |
| Somnolence | 46.48 | 9.62 | 385 | 97418 | 208699 | 90321945 |
| Discomfort | 46.25 | 9.62 | 147 | 97656 | 274188 | 90256456 |
| Adulterated product | 46.13 | 9.62 | 17 | 97786 | 377 | 90530267 |
| Myocardial infarction | 45.84 | 9.62 | 231 | 97572 | 105741 | 90424903 |
| Liver disorder | 44.70 | 9.62 | 39 | 97764 | 121230 | 90409414 |
| Headache | 44.58 | 9.62 | 1232 | 96571 | 861514 | 89669130 |
| Night sweats | 44.41 | 9.62 | 44 | 97759 | 128722 | 90401922 |
| Unresponsive to stimuli | 44.38 | 9.62 | 115 | 97688 | 38006 | 90492638 |
| Hypothermia | 43.86 | 9.62 | 68 | 97735 | 15507 | 90515137 |
| Hypertensive emergency | 43.27 | 9.62 | 28 | 97775 | 2189 | 90528455 |
| Hypersensitivity | 43.26 | 9.62 | 710 | 97093 | 453967 | 90076677 |
| Acute motor-sensory axonal neuropathy | 43.24 | 9.62 | 16 | 97787 | 359 | 90530285 |
| Cardiac arrest | 42.79 | 9.62 | 225 | 97578 | 104710 | 90425934 |
| Intestinal angioedema | 42.61 | 9.62 | 20 | 97783 | 828 | 90529816 |
| Malignant catatonia | 42.35 | 9.62 | 14 | 97789 | 222 | 90530422 |
| Peripheral venous disease | 41.92 | 9.62 | 19 | 97784 | 83902 | 90446742 |
| Respiratory arrest | 41.39 | 9.62 | 103 | 97700 | 33208 | 90497436 |
| Thrombocytopenia | 41.00 | 9.62 | 374 | 97429 | 208351 | 90322293 |
| Anuria | 40.76 | 9.62 | 64 | 97739 | 14754 | 90515890 |
| Condition aggravated | 39.71 | 9.62 | 431 | 97372 | 595114 | 89935530 |
| Walking aid user | 39.19 | 9.62 | 105 | 97698 | 35401 | 90495243 |
| Poor quality sleep | 39.11 | 9.62 | 84 | 97719 | 24609 | 90506035 |
| Malignant hypertension | 38.69 | 9.62 | 21 | 97782 | 1186 | 90529458 |
| Peritonitis bacterial | 38.58 | 9.62 | 37 | 97766 | 5134 | 90525510 |
| Disease progression | 38.25 | 9.62 | 69 | 97734 | 156546 | 90374098 |
| Musculoskeletal pain | 37.88 | 9.62 | 80 | 97723 | 171171 | 90359473 |
| Interstitial lung disease | 37.08 | 9.62 | 18 | 97785 | 76387 | 90454257 |
| Rheumatoid arthritis | 37.01 | 9.62 | 573 | 97230 | 362041 | 90168603 |
| Agitation | 36.95 | 9.62 | 157 | 97646 | 66941 | 90463703 |
| Implant site extravasation | 36.89 | 9.62 | 16 | 97787 | 549 | 90530095 |
| Anti-cyclic citrullinated peptide antibody | 36.85 | 9.62 | 87 | 97716 | 27134 | 90503510 |
| Claustrophobia | 36.83 | 9.62 | 21 | 97782 | 1306 | 90529338 |
| Malaise | 36.74 | 9.62 | 430 | 97373 | 585556 | 89945088 |
| Live birth | 36.37 | 9.62 | 20 | 97783 | 79087 | 90451557 |
| Extrapyramidal disorder | 36.25 | 9.62 | 64 | 97739 | 16239 | 90514405 |
| Psoriatic arthropathy | 35.98 | 9.62 | 126 | 97677 | 228209 | 90302435 |
| Aggression | 35.85 | 9.62 | 85 | 97718 | 26583 | 90504061 |
| Lung disorder | 35.74 | 9.62 | 67 | 97736 | 149816 | 90380828 |
| Skin induration | 35.68 | 9.62 | 29 | 97774 | 3233 | 90527411 |
| Nodal rhythm | 35.58 | 9.62 | 23 | 97780 | 1795 | 90528849 |
| Spinal fusion surgery | 35.11 | 9.62 | 54 | 97749 | 12229 | 90518415 |
| Systolic dysfunction | 34.61 | 9.62 | 23 | 97780 | 1881 | 90528763 |
| Abdominal pain upper | 34.40 | 9.62 | 214 | 97589 | 332460 | 90198184 |
| Nasopharyngitis | 33.79 | 9.62 | 279 | 97524 | 406825 | 90123819 |
| Chronic kidney disease | 33.73 | 9.62 | 125 | 97678 | 50066 | 90480578 |
| Impaired quality of life | 33.56 | 9.62 | 76 | 97727 | 23068 | 90507576 |
| Tachycardia | 32.74 | 9.62 | 286 | 97517 | 157387 | 90373257 |
| Abortion spontaneous | 32.53 | 9.62 | 9 | 97794 | 54047 | 90476597 |
| White blood cell count decreased | 32.21 | 9.62 | 84 | 97719 | 167025 | 90363619 |
| Psychomotor hyperactivity | 32.05 | 9.62 | 53 | 97750 | 12760 | 90517884 |
| Blepharospasm | 31.96 | 9.62 | 10 | 97793 | 55435 | 90475209 |
| Hyperlipidaemia | 31.85 | 9.62 | 74 | 97729 | 22842 | 90507802 |
| Rheumatoid factor positive | 31.79 | 9.62 | 88 | 97715 | 171562 | 90359082 |
| Folliculitis | 31.37 | 9.62 | 114 | 97689 | 204239 | 90326405 |
| Pulse abnormal | 30.82 | 9.62 | 26 | 97777 | 3053 | 90527591 |
| Spondylitis | 30.68 | 9.62 | 55 | 97748 | 14123 | 90516521 |
| Acute myocardial infarction | 30.59 | 9.62 | 95 | 97708 | 34795 | 90495849 |
| Dissociation | 30.58 | 9.62 | 37 | 97766 | 6678 | 90523966 |
| Product substitution issue | 30.54 | 9.62 | 63 | 97740 | 17945 | 90512699 |
| Coronary artery disease | 29.90 | 9.62 | 92 | 97711 | 33531 | 90497113 |
| Left ventricular hypertrophy | 29.86 | 9.62 | 35 | 97768 | 6109 | 90524535 |
| Respiratory depression | 29.42 | 9.62 | 57 | 97746 | 15518 | 90515126 |
| Taste disorder | 29.11 | 9.62 | 15 | 97788 | 61531 | 90469113 |
| Joint stiffness | 28.88 | 9.62 | 163 | 97640 | 77879 | 90452765 |
| Muscle injury | 28.83 | 9.62 | 96 | 97707 | 176558 | 90354086 |
| Diarrhoea | 28.74 | 9.62 | 783 | 97020 | 938407 | 89592237 |
| Blister | 28.49 | 9.62 | 160 | 97643 | 254838 | 90275806 |
| Pathergy reaction | 28.22 | 9.62 | 8 | 97795 | 73 | 90530571 |
| Respiratory moniliasis | 27.87 | 9.62 | 10 | 97793 | 205 | 90530439 |
| Neutrophil count decreased | 27.59 | 9.62 | 22 | 97781 | 71510 | 90459134 |
| Skin hypertrophy | 27.25 | 9.62 | 26 | 97777 | 3584 | 90527060 |
| Medical device site pain | 27 | 9.62 | 10 | 97793 | 225 | 90530419 |
| Delirium | 26.95 | 9.62 | 199 | 97604 | 104160 | 90426484 |
| Depressed level of consciousness | 26.92 | 9.62 | 152 | 97651 | 72632 | 90458012 |
| Lethargy | 26.85 | 9.62 | 137 | 97666 | 63002 | 90467642 |
| Schizencephaly | 26.68 | 9.62 | 11 | 97792 | 332 | 90530312 |
| Anaesthesia | 26.62 | 9.62 | 12 | 97791 | 452 | 90530192 |
| Purpura | 26.61 | 9.62 | 53 | 97750 | 14725 | 90515919 |
| Cerebral haemorrhage foetal | 26.53 | 9.62 | 11 | 97792 | 337 | 90530307 |
| Sleep disorder due to general medical condition, insomnia type | 26.11 | 9.62 | 63 | 97740 | 128631 | 90402013 |
| Mucosal erosion | 25.85 | 9.62 | 19 | 97784 | 1826 | 90528818 |
| Epilepsy with myoclonic-atonic seizures | 25.59 | 9.62 | 8 | 97795 | 105 | 90530539 |
| Basal ganglion degeneration | 25.54 | 9.62 | 11 | 97792 | 371 | 90530273 |
| Sinusitis | 25.43 | 9.62 | 242 | 97561 | 342846 | 90187798 |
| Drug intolerance | 25.18 | 9.62 | 336 | 97467 | 447255 | 90083389 |
| Hypertensive urgency | 24.99 | 9.62 | 13 | 97790 | 673 | 90529971 |
| Accidental overdose | 24.80 | 9.62 | 77 | 97726 | 28196 | 90502448 |
| Miosis | 24.76 | 9.62 | 40 | 97763 | 9444 | 90521200 |
| Retching | 24.61 | 9.62 | 60 | 97743 | 19099 | 90511545 |
| Retrograde amnesia | 24.59 | 9.62 | 12 | 97791 | 542 | 90530102 |
| Osteonecrosis of jaw | 24.50 | 9.62 | 6 | 97797 | 39097 | 90491547 |
| Injection site erythema | 24.40 | 9.62 | 43 | 97760 | 98459 | 90432185 |
| Human ehrlichiosis | 24.36 | 9.62 | 9 | 97794 | 201 | 90530443 |
| Nail disorder | 24.29 | 9.62 | 17 | 97786 | 59050 | 90471594 |
| Epilepsy | 24.10 | 9.62 | 32 | 97771 | 82174 | 90448470 |
| Primary hyperaldosteronism | 23.52 | 9.62 | 7 | 97796 | 77 | 90530567 |
| Gastrooesophageal reflux disease | 23.46 | 9.62 | 96 | 97707 | 166241 | 90364403 |
| Macular degeneration | 23.46 | 9.62 | 6 | 97797 | 37964 | 90492680 |
| Hepatitis | 23.45 | 9.62 | 25 | 97778 | 70714 | 90459930 |
| BRASH syndrome | 23.33 | 9.62 | 18 | 97785 | 1861 | 90528783 |
| Lupus-like syndrome | 22.92 | 9.62 | 109 | 97694 | 48737 | 90481907 |
| Sleep disorder | 22.80 | 9.62 | 123 | 97680 | 197907 | 90332737 |
| Retinitis | 22.75 | 9.62 | 92 | 97711 | 38366 | 90492278 |
| Hepatic cirrhosis | 22.68 | 9.62 | 131 | 97672 | 63122 | 90467522 |
| Somatic symptom disorder | 22.66 | 9.62 | 23 | 97780 | 3418 | 90527226 |
| Hypercholesterolaemia | 22.51 | 9.62 | 186 | 97617 | 100706 | 90429938 |
| Alanine aminotransferase increased | 22.41 | 9.62 | 60 | 97743 | 118278 | 90412366 |
| Hepatic function abnormal | 22.32 | 9.62 | 11 | 97792 | 46277 | 90484367 |
| COVID-19 | 22.25 | 9.62 | 100 | 97703 | 168743 | 90361901 |
| Hypoventilation | 22.21 | 9.62 | 28 | 97775 | 5268 | 90525376 |
| Peripheral swelling | 22.20 | 9.62 | 313 | 97490 | 412793 | 90117851 |
| Musculoskeletal stiffness | 22.03 | 9.62 | 209 | 97594 | 296323 | 90234321 |
| Device infusion issue | 21.68 | 9.62 | 20 | 97783 | 2642 | 90528002 |
| Ear infection | 21.53 | 9.62 | 139 | 97664 | 69636 | 90461008 |
| Colitis ulcerative | 21.46 | 9.62 | 20 | 97783 | 60246 | 90470398 |
| Catheter site granuloma | 21.34 | 9.62 | 5 | 97798 | 19 | 90530625 |
| Impaired work ability | 21.17 | 9.62 | 57 | 97746 | 19269 | 90511375 |
| Bone density decreased | 20.89 | 9.62 | 53 | 97750 | 17292 | 90513352 |
| Blood aldosterone increased | 20.78 | 9.62 | 8 | 97795 | 201 | 90530443 |
| Onychomadesis | 20.61 | 9.62 | 12 | 97791 | 45986 | 90484658 |
| Genital erosion | 20.46 | 9.62 | 10 | 97793 | 453 | 90530191 |
| Norepinephrine increased | 20.41 | 9.62 | 6 | 97797 | 63 | 90530581 |
| Rheumatic fever | 19.98 | 9.62 | 91 | 97712 | 153030 | 90377614 |
| Rhinorrhoea | 19.74 | 9.62 | 41 | 97762 | 88275 | 90442369 |
| Apnoea | 19.71 | 9.62 | 36 | 97767 | 9378 | 90521266 |
| Dialysis | 19.64 | 9.62 | 40 | 97763 | 11289 | 90519355 |
| Application site papules | 19.61 | 9.62 | 6 | 97797 | 73 | 90530571 |
| Skin disorder | 19.52 | 9.62 | 85 | 97718 | 36621 | 90494023 |
| Tissue infiltration | 19.52 | 9.62 | 12 | 97791 | 858 | 90529786 |
| Seizure | 19.49 | 9.62 | 251 | 97552 | 152378 | 90378266 |
| Pregnancy | 19.39 | 9.62 | 23 | 97780 | 62024 | 90468620 |
| Iliac artery stenosis | 19.39 | 9.62 | 6 | 97797 | 76 | 90530568 |
| Brain injury | 19.34 | 9.62 | 32 | 97771 | 7706 | 90522938 |
| Device expulsion | 19.29 | 9.62 | 10 | 97793 | 40876 | 90489768 |
| Paraesthesia | 19.21 | 9.62 | 175 | 97628 | 250151 | 90280493 |
| Sympathomimetic effect | 19.18 | 9.62 | 7 | 97796 | 151 | 90530493 |
| Disability | 19.17 | 9.62 | 91 | 97712 | 40654 | 90489990 |
| Drug ineffective | 19.12 | 9.62 | 1263 | 96540 | 1383035 | 89147609 |
| Fibrous dysplasia of jaw | 18.95 | 9.62 | 4 | 97799 | 8 | 90530636 |
| Obesity | 18.86 | 9.62 | 55 | 97748 | 105452 | 90425192 |
| Intentional overdose | 18.85 | 9.62 | 169 | 97634 | 93665 | 90436979 |
| Drug dependence | 18.84 | 9.62 | 72 | 97731 | 29255 | 90501389 |
| Lupus vulgaris | 18.62 | 9.62 | 97 | 97706 | 44962 | 90485682 |
| Encephalomalacia | 18.62 | 9.62 | 10 | 97793 | 553 | 90530091 |
| Feeling of despair | 18.56 | 9.62 | 20 | 97783 | 3184 | 90527460 |
| Urinary incontinence | 18.48 | 9.62 | 85 | 97718 | 37481 | 90493163 |
| Haematochezia | 18.45 | 9.62 | 30 | 97773 | 70883 | 90459761 |
| Product use issue | 18.33 | 9.62 | 476 | 97327 | 329443 | 90201201 |
| Stomatitis | 18.18 | 9.62 | 199 | 97604 | 274499 | 90256145 |
| Neoplasm progression | 18.03 | 9.62 | 13 | 97790 | 44473 | 90486171 |
| Medical device site discharge | 18.01 | 9.62 | 5 | 97798 | 42 | 90530602 |
| Secondary hypertension | 17.91 | 9.62 | 8 | 97795 | 295 | 90530349 |
| Atrioventricular block second degree | 17.82 | 9.62 | 23 | 97780 | 4429 | 90526215 |
| Application site vesicles | 17.68 | 9.62 | 14 | 97789 | 1503 | 90529141 |
| Drug screen positive | 17.60 | 9.62 | 21 | 97782 | 3736 | 90526908 |
| Renin decreased | 17.55 | 9.62 | 6 | 97797 | 106 | 90530538 |
| Pernicious anaemia | 17.17 | 9.62 | 11 | 97792 | 845 | 90529799 |
| Therapeutic product effect incomplete | 16.93 | 9.62 | 131 | 97672 | 193765 | 90336879 |
| Normochromic normocytic anaemia | 16.84 | 9.62 | 24 | 97779 | 5078 | 90525566 |
| Croup infectious | 16.76 | 9.62 | 10 | 97793 | 677 | 90529967 |
| Neurological symptom | 16.69 | 9.62 | 28 | 97775 | 6819 | 90523825 |
| Gastrointestinal tract mucosal pigmentation | 16.47 | 9.62 | 10 | 97793 | 699 | 90529945 |
| Coma scale abnormal | 16.46 | 9.62 | 25 | 97778 | 5601 | 90525043 |
| Mobility decreased | 16.45 | 9.62 | 182 | 97621 | 250552 | 90280092 |
| Pulse absent | 16.44 | 9.62 | 26 | 97777 | 6029 | 90524615 |
| Myocardial ischaemia | 16.42 | 9.62 | 42 | 97761 | 13772 | 90516872 |
| Respiratory tract infection | 16.32 | 9.62 | 24 | 97779 | 59054 | 90471590 |
| Vascular stenosis | 16.28 | 9.62 | 9 | 97794 | 527 | 90530117 |
| X-ray abnormal | 16.26 | 9.62 | 15 | 97788 | 45409 | 90485235 |
| Application site discolouration | 16.26 | 9.62 | 11 | 97792 | 927 | 90529717 |
| Electrocardiogram PR shortened | 16.20 | 9.62 | 9 | 97794 | 532 | 90530112 |
| Implant site infection | 16.11 | 9.62 | 12 | 97791 | 1177 | 90529467 |
| Medical device site erythema | 16.02 | 9.62 | 4 | 97799 | 21 | 90530623 |
| Hyperreflexia | 15.93 | 9.62 | 27 | 97776 | 6630 | 90524014 |
| Pain | 15.87 | 9.62 | 1264 | 96539 | 995077 | 89535567 |
| Melaena | 15.70 | 9.62 | 9 | 97794 | 34788 | 90495856 |
| Cerebral ischaemia | 15.68 | 9.62 | 28 | 97775 | 7168 | 90523476 |
| Femur fracture | 15.59 | 9.62 | 16 | 97787 | 46066 | 90484578 |
| Laryngitis | 15.59 | 9.62 | 101 | 97702 | 50652 | 90479992 |
| Pulmonary renal syndrome | 15.55 | 9.62 | 9 | 97794 | 576 | 90530068 |
| Prescribed underdose | 15.52 | 9.62 | 136 | 97667 | 74883 | 90455761 |
| Gamma-glutamyltransferase increased | 15.50 | 9.62 | 11 | 97792 | 37941 | 90492703 |
| Akathisia | 15.47 | 9.62 | 36 | 97767 | 11123 | 90519521 |
| Application site pain | 15.28 | 9.62 | 22 | 97781 | 4698 | 90525946 |
| Cerebellar atrophy | 15.28 | 9.62 | 10 | 97793 | 797 | 90529847 |
| Rash maculo-papular | 15.28 | 9.62 | 13 | 97790 | 40920 | 90489724 |
| Product use in unapproved indication | 15.26 | 9.62 | 263 | 97540 | 335973 | 90194671 |
| Focal segmental glomerulosclerosis | 15.26 | 9.62 | 14 | 97789 | 1837 | 90528807 |
| Electrocardiogram QRS complex prolonged | 15.26 | 9.62 | 28 | 97775 | 7320 | 90523324 |
| Glomerulonephritis rapidly progressive | 15.24 | 9.62 | 12 | 97791 | 1278 | 90529366 |
| Rash | 15.06 | 9.62 | 704 | 97099 | 795396 | 89735248 |
| Onychomycosis | 15.05 | 9.62 | 11 | 97792 | 37365 | 90493279 |
| Page kidney | 15.04 | 9.62 | 4 | 97799 | 28 | 90530616 |
| Transaminases increased | 14.90 | 9.62 | 11 | 97792 | 37181 | 90493463 |
| Anhedonia | 14.90 | 9.62 | 36 | 97767 | 11395 | 90519249 |
| Frequent bowel movements | 14.89 | 9.62 | 24 | 97779 | 56911 | 90473733 |
| Human herpesvirus 6 infection reactivation | 14.88 | 9.62 | 9 | 97794 | 625 | 90530019 |
| Uterine enlargement | 14.78 | 9.62 | 12 | 97791 | 1336 | 90529308 |
| Pneumonia respiratory syncytial viral | 14.75 | 9.62 | 12 | 97791 | 1339 | 90529305 |
| Breast cancer stage II | 14.75 | 9.62 | 10 | 97793 | 35324 | 90495320 |
| Helicobacter infection | 14.74 | 9.62 | 165 | 97638 | 226685 | 90303959 |
| Exostosis | 14.68 | 9.62 | 103 | 97700 | 53031 | 90477613 |
| Productive cough | 14.64 | 9.62 | 39 | 97764 | 77024 | 90453620 |
| Cytokine release syndrome | 14.50 | 9.62 | 6 | 97797 | 27967 | 90502677 |
| Adverse reaction | 14.42 | 9.62 | 7 | 97796 | 29705 | 90500939 |
| Renal transplant failure | 14.40 | 9.62 | 11 | 97792 | 1121 | 90529523 |
| Feeling abnormal | 14.35 | 9.62 | 257 | 97546 | 166978 | 90363666 |
| Short-bowel syndrome | 14.32 | 9.62 | 9 | 97794 | 669 | 90529975 |
| Chest discomfort | 14.29 | 9.62 | 89 | 97714 | 138276 | 90392368 |
| Hyperaesthesia | 14.26 | 9.62 | 34 | 97769 | 10668 | 90519976 |
| Device wireless communication issue | 14.24 | 9.62 | 5 | 97798 | 96 | 90530548 |
| Anxiety | 14.16 | 9.62 | 436 | 97367 | 309336 | 90221308 |
| Sinus arrhythmia | 14.02 | 9.62 | 12 | 97791 | 1437 | 90529207 |
| Cardiac hypertrophy | 14.01 | 9.62 | 11 | 97792 | 1167 | 90529477 |
| Therapeutic drug monitoring analysis incorrectly performed | 13.99 | 9.62 | 7 | 97796 | 334 | 90530310 |
| Injection site abscess | 13.98 | 9.62 | 12 | 97791 | 1442 | 90529202 |
| Hypertrichosis | 13.81 | 9.62 | 12 | 97791 | 1467 | 90529177 |
| Inguinal hernia | 13.77 | 9.62 | 14 | 97789 | 2084 | 90528560 |
| Tachyphylaxis | 13.76 | 9.62 | 7 | 97796 | 346 | 90530298 |
| Exposure to allergen | 13.40 | 9.62 | 8 | 97795 | 542 | 90530102 |
| Basal ganglia haemorrhage | 13.37 | 9.62 | 9 | 97794 | 752 | 90529892 |
| Renal artery stenosis | 13.34 | 9.62 | 14 | 97789 | 2163 | 90528481 |
| Foot deformity | 13.32 | 9.62 | 110 | 97693 | 59541 | 90471103 |
| Cytomegalovirus infection | 13.32 | 9.62 | 6 | 97797 | 26596 | 90504048 |
| Breast cancer stage I | 13.29 | 9.62 | 31 | 97772 | 9593 | 90521051 |
| Hepatotoxicity | 13.28 | 9.62 | 18 | 97785 | 45824 | 90484820 |
| Blood pressure abnormal | 13.26 | 9.62 | 49 | 97754 | 19596 | 90511048 |
| Paranoia | 13.08 | 9.62 | 37 | 97766 | 12871 | 90517773 |
| Bone erosion | 13.06 | 9.62 | 100 | 97703 | 52921 | 90477723 |
| Klebsiella infection | 12.96 | 9.62 | 32 | 97771 | 10265 | 90520379 |
| C-reactive protein | 12.93 | 9.62 | 9 | 97794 | 31358 | 90499286 |
| Change in seizure presentation | 12.86 | 9.62 | 8 | 97795 | 584 | 90530060 |
| Bundle branch block left | 12.69 | 9.62 | 27 | 97776 | 7858 | 90522786 |
| Irritable bowel syndrome | 12.66 | 9.62 | 153 | 97650 | 207295 | 90323349 |
| Exposure via ingestion | 12.64 | 9.62 | 15 | 97788 | 2652 | 90527992 |
| Hepatic cytolysis | 12.57 | 9.62 | 9 | 97794 | 30907 | 90499737 |
| Drug abuser | 12.54 | 9.62 | 15 | 97788 | 2675 | 90527969 |
| Cognitive disorder | 12.53 | 9.62 | 36 | 97767 | 69371 | 90461273 |
| Rash pruritic | 12.52 | 9.62 | 46 | 97757 | 82168 | 90448476 |
| Injection site swelling | 12.37 | 9.62 | 29 | 97774 | 59810 | 90470834 |
| Neurological decompensation | 12.35 | 9.62 | 17 | 97786 | 3484 | 90527160 |
| Drug eruption | 12.32 | 9.62 | 12 | 97791 | 35395 | 90495249 |
| Skin fibrosis | 12.12 | 9.62 | 9 | 97794 | 879 | 90529765 |
| Pruritus | 12.08 | 9.62 | 470 | 97333 | 541055 | 89989589 |
| Intercepted medication error | 12.04 | 9.62 | 9 | 97794 | 888 | 90529756 |
| Basal cell carcinoma | 11.98 | 9.62 | 11 | 97792 | 33378 | 90497266 |
| Chloasma | 11.94 | 9.62 | 5 | 97798 | 157 | 90530487 |
| Loss of consciousness | 11.85 | 9.62 | 215 | 97588 | 140023 | 90390621 |
| Trichostasis spinulosa | 11.83 | 9.62 | 3 | 97800 | 17 | 90530627 |
| Acute lung injury | 11.71 | 9.62 | 11 | 97792 | 1487 | 90529157 |
| Creatinine renal clearance decreased | 11.65 | 9.62 | 3 | 97800 | 18896 | 90511748 |
| Hyperlactacidaemia | 11.57 | 9.62 | 18 | 97785 | 4118 | 90526526 |
| Patent ductus arteriosus | 11.56 | 9.62 | 19 | 97784 | 4550 | 90526094 |
| Maternal use of illicit drugs | 11.54 | 9.62 | 3 | 97800 | 19 | 90530625 |
| Acute myeloid leukaemia | 11.41 | 9.62 | 4 | 97799 | 20636 | 90510008 |
| Dermoid cyst | 11.38 | 9.62 | 7 | 97796 | 501 | 90530143 |
| Kidney fibrosis | 11.32 | 9.62 | 13 | 97790 | 2221 | 90528423 |
| Adjustment disorder with depressed mood | 11.28 | 9.62 | 102 | 97701 | 56651 | 90473993 |
| Aspartate aminotransferase increased | 11.26 | 9.62 | 65 | 97738 | 102872 | 90427772 |
| Labile blood pressure | 11.20 | 9.62 | 12 | 97791 | 1898 | 90528746 |
| End stage renal disease | 11.18 | 9.62 | 27 | 97776 | 8544 | 90522100 |
| Implant site haematoma | 11.15 | 9.62 | 4 | 97799 | 82 | 90530562 |
| Hypertensive heart disease | 11.14 | 9.62 | 14 | 97789 | 2626 | 90528018 |
| Left atrial dilatation | 11.07 | 9.62 | 12 | 97791 | 1924 | 90528720 |
| Infusion site infection | 11.06 | 9.62 | 14 | 97789 | 2646 | 90527998 |
| Mood swings | 11.05 | 9.62 | 48 | 97755 | 20654 | 90509990 |
| Medical device site swelling | 11.04 | 9.62 | 3 | 97800 | 23 | 90530621 |
| Back injury | 10.97 | 9.62 | 21 | 97782 | 46601 | 90484043 |
| Suicidal ideation | 10.97 | 9.62 | 125 | 97678 | 73730 | 90456914 |
| Pain in jaw | 10.96 | 9.62 | 22 | 97781 | 47963 | 90482681 |
| Neutropenic sepsis | 10.94 | 9.62 | 3 | 97800 | 18127 | 90512517 |
| Rectal haemorrhage | 10.90 | 9.62 | 49 | 97754 | 82695 | 90447949 |
| Left ventricular failure | 10.85 | 9.62 | 23 | 97780 | 6677 | 90523967 |
| Dislocation of vertebra | 10.83 | 9.62 | 100 | 97703 | 55868 | 90474776 |
| Renal failure | 10.77 | 9.62 | 200 | 97603 | 130807 | 90399837 |
| Urine output decreased | 10.76 | 9.62 | 34 | 97769 | 12569 | 90518075 |
| Emotional distress | 10.68 | 9.62 | 72 | 97731 | 36590 | 90494054 |
| Psychogenic seizure | 10.67 | 9.62 | 12 | 97791 | 2004 | 90528640 |
| Chest pain | 10.66 | 9.62 | 434 | 97369 | 319211 | 90211433 |
| Postoperative hypertension | 10.62 | 9.62 | 3 | 97800 | 27 | 90530617 |
| Hypernatraemia | 10.60 | 9.62 | 28 | 97775 | 9359 | 90521285 |
| Joint effusion | 10.59 | 9.62 | 4 | 97799 | 19706 | 90510938 |
| Skin tightness | 10.47 | 9.62 | 18 | 97785 | 4470 | 90526174 |
| Joint contracture | 10.42 | 9.62 | 11 | 97792 | 1711 | 90528933 |
| Device failure | 10.39 | 9.62 | 23 | 97780 | 6874 | 90523770 |
| Haemorrhage intracranial | 10.38 | 9.62 | 38 | 97765 | 15124 | 90515520 |
| Impaired healing | 10.36 | 9.62 | 184 | 97619 | 234015 | 90296629 |
| Application site haematoma | 10.34 | 9.62 | 3 | 97800 | 30 | 90530614 |
| Joint injury | 10.32 | 9.62 | 12 | 97791 | 32652 | 90497992 |
| Cytopenia | 10.32 | 9.62 | 3 | 97800 | 17446 | 90513198 |
| Arteriospasm coronary | 10.18 | 9.62 | 19 | 97784 | 5031 | 90525613 |
| Implant site hypersensitivity | 10.08 | 9.62 | 3 | 97800 | 33 | 90530611 |
| Hypersomnia | 10.06 | 9.62 | 48 | 97755 | 21483 | 90509161 |
| Alcoholism | 10.02 | 9.62 | 11 | 97792 | 1789 | 90528855 |
| Myalgia | 10.00 | 9.62 | 131 | 97672 | 174994 | 90355650 |
| Drug ineffective for unapproved indication | 9.99 | 9.62 | 113 | 97690 | 66531 | 90464113 |
| Electrocardiogram abnormal | 9.93 | 9.62 | 29 | 97774 | 10269 | 90520375 |
| Injection site pain | 9.89 | 9.62 | 130 | 97673 | 173569 | 90357075 |
| Cerebral atrophy | 9.87 | 9.62 | 20 | 97783 | 5626 | 90525018 |
| Posterior reversible encephalopathy syndrome | 9.87 | 9.62 | 49 | 97754 | 22290 | 90508354 |
| Blood bilirubin increased | 9.86 | 9.62 | 20 | 97783 | 43450 | 90487194 |
| Drug withdrawal convulsions | 9.83 | 9.62 | 10 | 97793 | 1490 | 90529154 |
| Bronchiectasis | 9.76 | 9.62 | 6 | 97797 | 22324 | 90508320 |
| Metastases to liver | 9.75 | 9.62 | 10 | 97793 | 28797 | 90501847 |
| Pancytopenia | 9.69 | 9.62 | 83 | 97720 | 120180 | 90410464 |
| Application site urticaria | 9.68 | 9.62 | 5 | 97798 | 255 | 90530389 |
| Peau d'orange | 9.66 | 9.62 | 4 | 97799 | 122 | 90530522 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Completed suicide | 338.87 | 11.38 | 483 | 48665 | 95982 | 42476205 |
| Drug withdrawal syndrome | 313.80 | 11.38 | 233 | 48915 | 21316 | 42550871 |
| Drug dependence | 194.48 | 11.38 | 202 | 48946 | 28892 | 42543295 |
| Bradycardia | 175.19 | 11.38 | 336 | 48812 | 85148 | 42487039 |
| Aggression | 174.11 | 11.38 | 234 | 48914 | 43929 | 42528258 |
| Respiratory depression | 169.31 | 11.38 | 154 | 48994 | 18714 | 42553473 |
| Withdrawal hypertension | 165.08 | 11.38 | 41 | 49107 | 194 | 42571993 |
| Withdrawal syndrome | 137.29 | 11.38 | 123 | 49025 | 14652 | 42557535 |
| Hypertension | 102.69 | 11.38 | 423 | 48725 | 166781 | 42405406 |
| Hypertensive crisis | 96.87 | 11.38 | 86 | 49062 | 10120 | 42562067 |
| Victim of child abuse | 96.32 | 11.38 | 40 | 49108 | 1149 | 42571038 |
| Obesity | 93.67 | 11.38 | 105 | 49043 | 16354 | 42555833 |
| Epidural lipomatosis | 92.47 | 11.38 | 44 | 49104 | 1756 | 42570431 |
| Oppositional defiant disorder | 85.19 | 11.38 | 30 | 49118 | 542 | 42571645 |
| Hypotension | 82.19 | 11.38 | 543 | 48605 | 257088 | 42315099 |
| Decreased eye contact | 80.07 | 11.38 | 28 | 49120 | 495 | 42571692 |
| Suspected suicide | 79.12 | 11.38 | 62 | 49086 | 6137 | 42566050 |
| Agitation | 76.75 | 11.38 | 204 | 48944 | 64110 | 42508077 |
| Juvenile idiopathic arthritis | 76.60 | 11.38 | 44 | 49104 | 2595 | 42569592 |
| Choreoathetosis | 75.56 | 11.38 | 33 | 49115 | 1076 | 42571111 |
| Mental status changes | 72.40 | 11.38 | 154 | 48994 | 41961 | 42530226 |
| Dystonia | 71.76 | 11.38 | 81 | 49067 | 12709 | 42559478 |
| Child abuse | 68.87 | 11.38 | 29 | 49119 | 863 | 42571324 |
| Blood pressure inadequately controlled | 65.54 | 11.38 | 41 | 49107 | 2827 | 42569360 |
| Application site rash | 65.43 | 11.38 | 29 | 49119 | 980 | 42571207 |
| Blood prolactin increased | 63.21 | 11.38 | 37 | 49111 | 2261 | 42569926 |
| Cardiac failure congestive | 61.75 | 11.38 | 228 | 48920 | 85374 | 42486813 |
| Febrile neutropenia | 61.71 | 11.38 | 74 | 49074 | 185629 | 42386558 |
| Anxiety | 61.30 | 11.38 | 285 | 48863 | 118275 | 42453912 |
| Accidental exposure to product by child | 58.93 | 11.38 | 31 | 49117 | 1536 | 42570651 |
| Product prescribing error | 58.84 | 11.38 | 107 | 49041 | 26005 | 42546182 |
| Lethargy | 58.24 | 11.38 | 151 | 48997 | 46739 | 42525448 |
| Sinus bradycardia | 57.42 | 11.38 | 78 | 49070 | 14775 | 42557412 |
| Blood pressure increased | 57.15 | 11.38 | 251 | 48897 | 101677 | 42470510 |
| Homicidal ideation | 56.55 | 11.38 | 37 | 49111 | 2757 | 42569430 |
| Sedation | 55.36 | 11.38 | 114 | 49034 | 30361 | 42541826 |
| Crying | 55.03 | 11.38 | 51 | 49097 | 6343 | 42565844 |
| Bruxism | 54.64 | 11.38 | 33 | 49115 | 2136 | 42570051 |
| Serotonin syndrome | 52.13 | 11.38 | 101 | 49047 | 25744 | 42546443 |
| Irritability | 50.83 | 11.38 | 105 | 49043 | 28023 | 42544164 |
| Trismus | 50.72 | 11.38 | 35 | 49113 | 2849 | 42569338 |
| Nephrogenic systemic fibrosis | 49.02 | 11.38 | 37 | 49111 | 3464 | 42568723 |
| Interstitial lung disease | 48.58 | 11.38 | 15 | 49133 | 78447 | 42493740 |
| Product substitution issue | 47.81 | 11.38 | 62 | 49086 | 11228 | 42560959 |
| Thrombocytopenia | 47.62 | 11.38 | 92 | 49056 | 190187 | 42382000 |
| Neuroleptic malignant syndrome | 47.13 | 11.38 | 87 | 49061 | 21385 | 42550802 |
| Overweight | 46.53 | 11.38 | 31 | 49117 | 2381 | 42569806 |
| Psychomotor hyperactivity | 46.13 | 11.38 | 60 | 49088 | 10898 | 42561289 |
| Suicidal ideation | 45.05 | 11.38 | 140 | 49008 | 48021 | 42524166 |
| Somnolence | 44.01 | 11.38 | 296 | 48852 | 140809 | 42431378 |
| Anal inflammation | 43.85 | 11.38 | 29 | 49119 | 2200 | 42569987 |
| Pneumonia | 43.41 | 11.38 | 297 | 48851 | 421852 | 42150335 |
| Catatonia | 42.89 | 11.38 | 44 | 49104 | 6195 | 42565992 |
| Product adhesion issue | 42.63 | 11.38 | 26 | 49122 | 1713 | 42570474 |
| Miosis | 42.26 | 11.38 | 64 | 49084 | 13382 | 42558805 |
| SARS-CoV-2 test negative | 42.14 | 11.38 | 26 | 49122 | 1749 | 42570438 |
| Toxicity to various agents | 41.49 | 11.38 | 425 | 48723 | 228711 | 42343476 |
| Hypertensive emergency | 41.36 | 11.38 | 23 | 49125 | 1274 | 42570913 |
| Respiratory arrest | 41.06 | 11.38 | 97 | 49051 | 28327 | 42543860 |
| Neutropenia | 40.49 | 11.38 | 108 | 49040 | 199323 | 42372864 |
| Malignant neoplasm progression | 39.50 | 11.38 | 40 | 49108 | 108360 | 42463827 |
| Dyskinesia | 39.27 | 11.38 | 89 | 49059 | 25301 | 42546886 |
| Pancytopenia | 38.99 | 11.38 | 47 | 49101 | 117696 | 42454491 |
| Cardiac arrest | 38.80 | 11.38 | 237 | 48911 | 109083 | 42463104 |
| Hypertensive urgency | 38.35 | 11.38 | 16 | 49132 | 465 | 42571722 |
| Hepatic function abnormal | 37.52 | 11.38 | 7 | 49141 | 51560 | 42520627 |
| Peritonitis bacterial | 37.44 | 11.38 | 43 | 49105 | 6872 | 42565315 |
| Tardive dyskinesia | 37.40 | 11.38 | 43 | 49105 | 6881 | 42565306 |
| Hyperaesthesia | 37.38 | 11.38 | 40 | 49108 | 5912 | 42566275 |
| Emotional distress | 36.32 | 11.38 | 66 | 49082 | 16027 | 42556160 |
| Device failure | 36.23 | 11.38 | 28 | 49120 | 2715 | 42569472 |
| Toxic epidermal necrolysis | 36.19 | 11.38 | 89 | 49059 | 26661 | 42545526 |
| Kidney transplant rejection | 35.70 | 11.38 | 47 | 49101 | 8636 | 42563551 |
| Myelosuppression | 35.44 | 11.38 | 3 | 49145 | 40458 | 42531729 |
| Cytokine release syndrome | 34.72 | 11.38 | 5 | 49143 | 44522 | 42527665 |
| Cerebrovascular accident | 34.71 | 11.38 | 211 | 48937 | 96949 | 42475238 |
| Application site pruritus | 34.66 | 11.38 | 22 | 49126 | 1556 | 42570631 |
| Product use issue | 34.26 | 11.38 | 177 | 48971 | 76574 | 42495613 |
| Overdose | 34.12 | 11.38 | 223 | 48925 | 105041 | 42467146 |
| Inadequate analgesia | 32.46 | 11.38 | 28 | 49120 | 3169 | 42569018 |
| Drug ineffective for unapproved indication | 32.46 | 11.38 | 122 | 49026 | 46041 | 42526146 |
| Affect lability | 32.39 | 11.38 | 31 | 49117 | 4013 | 42568174 |
| Aplastic anaemia | 32.12 | 11.38 | 54 | 49094 | 12330 | 42559857 |
| Disease progression | 32.11 | 11.38 | 74 | 49074 | 143582 | 42428605 |
| Pyrexia | 30.08 | 11.38 | 300 | 48848 | 393742 | 42178445 |
| Hypotonia | 29.55 | 11.38 | 45 | 49103 | 9454 | 42562733 |
| Malignant catatonia | 29.15 | 11.38 | 13 | 49135 | 446 | 42571741 |
| General physical health deterioration | 29.12 | 11.38 | 84 | 49064 | 151162 | 42421025 |
| Social problem | 29.08 | 11.38 | 18 | 49130 | 1218 | 42570969 |
| Autonomic nervous system imbalance | 29.05 | 11.38 | 26 | 49122 | 3090 | 42569097 |
| Accidental overdose | 28.98 | 11.38 | 85 | 49063 | 28245 | 42543942 |
| Application site irritation | 28.86 | 11.38 | 15 | 49133 | 725 | 42571462 |
| Unresponsive to stimuli | 28.18 | 11.38 | 90 | 49058 | 31313 | 42540874 |
| Injury | 27.84 | 11.38 | 72 | 49076 | 22244 | 42549943 |
| Neutrophil count decreased | 27.23 | 11.38 | 20 | 49128 | 63395 | 42508792 |
| Application site erythema | 27.13 | 11.38 | 23 | 49125 | 2543 | 42569644 |
| Tic | 26.52 | 11.38 | 22 | 49126 | 2361 | 42569826 |
| Rheumatoid arthritis | 26.47 | 11.38 | 8 | 49140 | 42432 | 42529755 |
| Accident | 26.43 | 11.38 | 35 | 49113 | 6468 | 42565719 |
| Pulmonary embolism | 26.41 | 11.38 | 62 | 49086 | 119550 | 42452637 |
| Intestinal pseudo-obstruction | 25.47 | 11.38 | 21 | 49127 | 2234 | 42569953 |
| Hyperhidrosis | 24.76 | 11.38 | 184 | 48964 | 90328 | 42481859 |
| Seizure | 24.40 | 11.38 | 229 | 48919 | 120332 | 42451855 |
| Renal transplant | 24.14 | 11.38 | 21 | 49127 | 2404 | 42569783 |
| COVID-19 | 24.11 | 11.38 | 62 | 49086 | 115886 | 42456301 |
| Abnormal behaviour | 23.91 | 11.38 | 76 | 49072 | 26375 | 42545812 |
| Accelerated hypertension | 23.89 | 11.38 | 10 | 49138 | 293 | 42571894 |
| Productive cough | 23.82 | 11.38 | 15 | 49133 | 51552 | 42520635 |
| Coordination abnormal | 23.45 | 11.38 | 37 | 49111 | 8013 | 42564174 |
| Drug screen positive | 22.89 | 11.38 | 26 | 49122 | 4105 | 42568082 |
| Device power source issue | 22.67 | 11.38 | 12 | 49136 | 602 | 42571585 |
| Sedation complication | 22.67 | 11.38 | 22 | 49126 | 2897 | 42569290 |
| Insomnia | 22.63 | 11.38 | 222 | 48926 | 118031 | 42454156 |
| Platelet count decreased | 22.49 | 11.38 | 83 | 49065 | 138498 | 42433689 |
| Drug tolerance | 22.25 | 11.38 | 23 | 49125 | 3267 | 42568920 |
| Galactorrhoea | 21.91 | 11.38 | 11 | 49137 | 494 | 42571693 |
| Attention deficit hyperactivity disorder | 21.51 | 11.38 | 22 | 49126 | 3086 | 42569101 |
| Drug withdrawal maintenance therapy | 21.34 | 11.38 | 8 | 49140 | 174 | 42572013 |
| Corneal reflex decreased | 21.29 | 11.38 | 8 | 49140 | 175 | 42572012 |
| Product prescribing issue | 20.95 | 11.38 | 32 | 49116 | 6741 | 42565446 |
| Pulmonary fibrosis | 20.79 | 11.38 | 3 | 49145 | 26678 | 42545509 |
| Tenderness | 20.77 | 11.38 | 37 | 49111 | 8846 | 42563341 |
| Hyperkinesia | 20.55 | 11.38 | 18 | 49130 | 2080 | 42570107 |
| Anger | 20.53 | 11.38 | 46 | 49102 | 12972 | 42559215 |
| Speech disorder | 20.50 | 11.38 | 77 | 49071 | 29044 | 42543143 |
| Lower respiratory tract infection | 20.44 | 11.38 | 11 | 49137 | 41195 | 42530992 |
| Poor quality sleep | 20.40 | 11.38 | 38 | 49110 | 9402 | 42562785 |
| C-reactive protein increased | 20.37 | 11.38 | 26 | 49122 | 63534 | 42508653 |
| Sepsis | 20.03 | 11.38 | 141 | 49007 | 199193 | 42372994 |
| White blood cell count decreased | 20.03 | 11.38 | 63 | 49085 | 110333 | 42461854 |
| Product administered to patient of inappropriate age | 19.93 | 11.38 | 26 | 49122 | 4735 | 42567452 |
| Oromandibular dystonia | 19.85 | 11.38 | 11 | 49137 | 605 | 42571582 |
| Natural killer cell count decreased | 19.41 | 11.38 | 4 | 49144 | 6 | 42572181 |
| Anhedonia | 19.40 | 11.38 | 33 | 49115 | 7607 | 42564580 |
| Mood altered | 19.35 | 11.38 | 40 | 49108 | 10678 | 42561509 |
| Tourette's disorder | 19.29 | 11.38 | 6 | 49142 | 72 | 42572115 |
| Pneumocystis jirovecii pneumonia | 19.23 | 11.38 | 3 | 49145 | 25178 | 42547009 |
| Labile hypertension | 18.72 | 11.38 | 6 | 49142 | 80 | 42572107 |
| Multiple organ dysfunction syndrome | 18.59 | 11.38 | 54 | 49094 | 96981 | 42475206 |
| Medical device site pain | 18.51 | 11.38 | 6 | 49142 | 83 | 42572104 |
| Paradoxical drug reaction | 18.49 | 11.38 | 25 | 49123 | 4713 | 42567474 |
| Hyponatraemia | 18.34 | 11.38 | 58 | 49090 | 101404 | 42470783 |
| Product preparation error | 18.32 | 11.38 | 25 | 49123 | 4753 | 42567434 |
| Myocardial infarction | 18.27 | 11.38 | 221 | 48927 | 123788 | 42448399 |
| Infection | 18.26 | 11.38 | 67 | 49081 | 112001 | 42460186 |
| Cardio-respiratory arrest | 18.24 | 11.38 | 123 | 49025 | 58513 | 42513674 |
| Prostate cancer | 18.00 | 11.38 | 15 | 49133 | 44628 | 42527559 |
| Stress cardiomyopathy | 17.99 | 11.38 | 19 | 49129 | 2766 | 42569421 |
| Pain | 17.80 | 11.38 | 388 | 48760 | 244460 | 42327727 |
| Gastrointestinal tract mucosal pigmentation | 17.73 | 11.38 | 10 | 49138 | 569 | 42571618 |
| Axillary pain | 17.55 | 11.38 | 9 | 49139 | 423 | 42571764 |
| Loss of consciousness | 16.99 | 11.38 | 172 | 48976 | 92182 | 42480005 |
| Implant site extravasation | 16.96 | 11.38 | 9 | 49139 | 454 | 42571733 |
| Brain injury | 16.77 | 11.38 | 31 | 49117 | 7624 | 42564563 |
| Hypoxic-ischaemic encephalopathy | 16.69 | 11.38 | 25 | 49123 | 5177 | 42567010 |
| Cardiac failure | 16.68 | 11.38 | 65 | 49083 | 106791 | 42465396 |
| Fibrosis | 16.67 | 11.38 | 19 | 49129 | 3011 | 42569176 |
| Posterior reversible encephalopathy syndrome | 16.64 | 11.38 | 42 | 49106 | 12779 | 42559408 |
| Arthralgia | 16.56 | 11.38 | 154 | 48994 | 205084 | 42367103 |
| Diarrhoea | 16.56 | 11.38 | 405 | 48743 | 460444 | 42111743 |
| Reaction to excipient | 16.49 | 11.38 | 10 | 49138 | 652 | 42571535 |
| Product preparation issue | 16.48 | 11.38 | 12 | 49136 | 1063 | 42571124 |
| Loss of libido | 16.47 | 11.38 | 19 | 49129 | 3051 | 42569136 |
| Intentional product misuse | 16.45 | 11.38 | 125 | 49023 | 61775 | 42510412 |
| Streptococcal infection | 16.25 | 11.38 | 27 | 49121 | 6105 | 42566082 |
| Colitis ulcerative | 16.20 | 11.38 | 5 | 49143 | 26170 | 42546017 |
| Skin induration | 15.87 | 11.38 | 15 | 49133 | 1912 | 42570275 |
| Depressed mood | 15.77 | 11.38 | 61 | 49087 | 23323 | 42548864 |
| Drooling | 15.74 | 11.38 | 22 | 49126 | 4277 | 42567910 |
| Self-destructive behaviour | 15.58 | 11.38 | 8 | 49140 | 377 | 42571810 |
| Lymphopenia | 15.53 | 11.38 | 3 | 49145 | 21560 | 42550627 |
| Mast cell degranulation present | 15.51 | 11.38 | 5 | 49143 | 68 | 42572119 |
| Agranulocytosis | 15.43 | 11.38 | 8 | 49140 | 30604 | 42541583 |
| Muscle spasticity | 15.42 | 11.38 | 28 | 49120 | 6794 | 42565393 |
| Double inlet left ventricle | 15.31 | 11.38 | 4 | 49144 | 24 | 42572163 |
| Rash | 15.30 | 11.38 | 226 | 48922 | 276728 | 42295459 |
| Autism spectrum disorder | 15.21 | 11.38 | 18 | 49130 | 2970 | 42569217 |
| Drug ineffective | 15.19 | 11.38 | 879 | 48269 | 629318 | 41942869 |
| Implant site pain | 15.19 | 11.38 | 6 | 49142 | 151 | 42572036 |
| Product compounding quality issue | 15.17 | 11.38 | 4 | 49144 | 25 | 42572162 |
| Drug abuse | 15.12 | 11.38 | 186 | 48962 | 104585 | 42467602 |
| Brief psychotic disorder with marked stressors | 15.00 | 11.38 | 7 | 49141 | 267 | 42571920 |
| Poisoning | 14.93 | 11.38 | 44 | 49104 | 14655 | 42557532 |
| Saccadic eye movement | 14.83 | 11.38 | 6 | 49142 | 161 | 42572026 |
| Left ventricular hypertrophy | 14.78 | 11.38 | 33 | 49115 | 9286 | 42562901 |
| Impulsive behaviour | 14.71 | 11.38 | 16 | 49132 | 2409 | 42569778 |
| Therapeutic product effect incomplete | 14.69 | 11.38 | 38 | 49110 | 70901 | 42501286 |
| Hyperbilirubinaemia | 14.59 | 11.38 | 3 | 49145 | 20632 | 42551555 |
| Accidental poisoning | 14.49 | 11.38 | 12 | 49136 | 1284 | 42570903 |
| Treatment noncompliance | 14.19 | 11.38 | 83 | 49065 | 37589 | 42534598 |
| Sprue-like enteropathy | 14.16 | 11.38 | 9 | 49139 | 638 | 42571549 |
| Septic shock | 14.16 | 11.38 | 56 | 49092 | 91616 | 42480571 |
| Incision site pain | 14.14 | 11.38 | 14 | 49134 | 1889 | 42570298 |
| Skin tightness | 14.14 | 11.38 | 15 | 49133 | 2195 | 42569992 |
| Subdural effusion | 14.01 | 11.38 | 5 | 49143 | 94 | 42572093 |
| Hepatitis | 13.96 | 11.38 | 7 | 49141 | 27293 | 42544894 |
| Lung disorder | 13.96 | 11.38 | 21 | 49127 | 47902 | 42524285 |
| Univentricular heart | 13.90 | 11.38 | 4 | 49144 | 36 | 42572151 |
| Respiratory rate decreased | 13.78 | 11.38 | 17 | 49131 | 2928 | 42569259 |
| Drug interaction | 13.74 | 11.38 | 404 | 48744 | 266595 | 42305592 |
| Renal artery stenosis | 13.55 | 11.38 | 15 | 49133 | 2302 | 42569885 |
| Autoimmune enteropathy | 13.52 | 11.38 | 4 | 49144 | 40 | 42572147 |
| Hydrocele male infected | 13.52 | 11.38 | 4 | 49144 | 40 | 42572147 |
| Restlessness | 13.42 | 11.38 | 68 | 49080 | 29181 | 42543006 |
| Frequent bowel movements | 13.41 | 11.38 | 4 | 49144 | 21403 | 42550784 |
| Psoriatic arthropathy | 13.39 | 11.38 | 6 | 49142 | 24961 | 42547226 |
| Akathisia | 13.32 | 11.38 | 34 | 49114 | 10417 | 42561770 |
| Renal tubular atrophy | 13.29 | 11.38 | 12 | 49136 | 1443 | 42570744 |
| Nervousness | 13.26 | 11.38 | 40 | 49108 | 13492 | 42558695 |
| Drug eruption | 13.25 | 11.38 | 5 | 49143 | 23070 | 42549117 |
| Metastases to eye | 13.24 | 11.38 | 5 | 49143 | 111 | 42572076 |
| Disseminated intravascular coagulation | 13.23 | 11.38 | 6 | 49142 | 24788 | 42547399 |
| Product quality issue | 13.18 | 11.38 | 48 | 49100 | 17834 | 42554353 |
| Obsessive-compulsive disorder | 13.16 | 11.38 | 26 | 49122 | 6717 | 42565470 |
| Harlequin syndrome | 13.15 | 11.38 | 3 | 49145 | 9 | 42572178 |
| Intentional self-injury | 13.12 | 11.38 | 43 | 49105 | 15159 | 42557028 |
| Tremor | 13.09 | 11.38 | 170 | 48978 | 96759 | 42475428 |
| Metabolic alkalosis | 12.98 | 11.38 | 14 | 49134 | 2087 | 42570100 |
| Skin hypertrophy | 12.89 | 11.38 | 16 | 49132 | 2773 | 42569414 |
| Inflammation | 12.88 | 11.38 | 12 | 49136 | 33835 | 42538352 |
| Cytomegalovirus infection | 12.84 | 11.38 | 11 | 49137 | 32295 | 42539892 |
| Renal injury | 12.70 | 11.38 | 37 | 49111 | 12243 | 42559944 |
| Lymphocele | 12.66 | 11.38 | 12 | 49136 | 1535 | 42570652 |
| Infusion site mass | 12.60 | 11.38 | 7 | 49141 | 387 | 42571800 |
| Joint contracture | 12.55 | 11.38 | 14 | 49134 | 2167 | 42570020 |
| Rash maculo-papular | 12.37 | 11.38 | 15 | 49133 | 37488 | 42534699 |
| Haemophagocytic lymphohistiocytosis | 12.18 | 11.38 | 3 | 49145 | 18219 | 42553968 |
| Hepatic cytolysis | 12.14 | 11.38 | 8 | 49140 | 26836 | 42545351 |
| Torticollis | 11.93 | 11.38 | 11 | 49137 | 1359 | 42570828 |
| Abdominal compartment syndrome | 11.88 | 11.38 | 10 | 49138 | 1095 | 42571092 |
| Device infusion issue | 11.85 | 11.38 | 10 | 49138 | 1098 | 42571089 |
| Anti-glomerular basement membrane disease | 11.69 | 11.38 | 4 | 49144 | 66 | 42572121 |
| Post transplant distal limb syndrome | 11.63 | 11.38 | 7 | 49141 | 450 | 42571737 |
| Alopecia | 11.60 | 11.38 | 10 | 49138 | 29266 | 42542921 |
| Psychotic symptom | 11.51 | 11.38 | 14 | 49134 | 2376 | 42569811 |
| Medical device site infection | 11.47 | 11.38 | 6 | 49142 | 294 | 42571893 |
| Pneumonitis | 11.46 | 11.38 | 19 | 49129 | 41699 | 42530488 |
| Clonus | 11.41 | 11.38 | 17 | 49131 | 3503 | 42568684 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Completed suicide | 953.41 | 10.02 | 1201 | 111034 | 241180 | 110235884 |
| Temperature regulation disorder | 598.68 | 10.02 | 282 | 111953 | 12544 | 110464520 |
| Food allergy | 476.08 | 10.02 | 280 | 111955 | 19668 | 110457396 |
| Drug withdrawal syndrome | 451.70 | 10.02 | 346 | 111889 | 37708 | 110439356 |
| Bradycardia | 391.19 | 10.02 | 623 | 111612 | 154894 | 110322170 |
| Immunodeficiency | 350.64 | 10.02 | 301 | 111934 | 38537 | 110438527 |
| Overdose | 306.47 | 10.02 | 710 | 111525 | 233084 | 110243980 |
| Hyperhidrosis | 299.17 | 10.02 | 616 | 111619 | 186682 | 110290382 |
| Coeliac disease | 292.66 | 10.02 | 285 | 111950 | 42902 | 110434162 |
| Hypertensive crisis | 281.33 | 10.02 | 218 | 112017 | 24154 | 110452910 |
| Hypertension | 233.29 | 10.02 | 1080 | 111155 | 509004 | 109968060 |
| Withdrawal syndrome | 229.50 | 10.02 | 216 | 112019 | 31164 | 110445900 |
| Foetal death | 221.98 | 10.02 | 160 | 112075 | 15885 | 110461179 |
| Fluid retention | 215.60 | 10.02 | 362 | 111873 | 93945 | 110383119 |
| Aggression | 212.75 | 10.02 | 281 | 111954 | 58929 | 110418135 |
| Mental status changes | 208.05 | 10.02 | 317 | 111918 | 75805 | 110401259 |
| Withdrawal hypertension | 207.51 | 10.02 | 54 | 112181 | 369 | 110476695 |
| Cardiac failure congestive | 207.05 | 10.02 | 467 | 111768 | 150533 | 110326531 |
| Suspected suicide | 199.90 | 10.02 | 147 | 112088 | 15052 | 110462012 |
| Respiratory depression | 199.81 | 10.02 | 202 | 112033 | 31799 | 110445265 |
| Toxicity to various agents | 191.27 | 10.02 | 978 | 111257 | 479577 | 109997487 |
| Rash erythematous | 186.89 | 10.02 | 314 | 111921 | 81518 | 110395546 |
| Drug dependence | 183.75 | 10.02 | 240 | 111995 | 49780 | 110427284 |
| Synovitis | 181.64 | 10.02 | 30 | 112205 | 274062 | 110203002 |
| Hypotension | 176.67 | 10.02 | 1019 | 111216 | 522830 | 109954234 |
| Intentional product misuse | 167.85 | 10.02 | 398 | 111837 | 132506 | 110344558 |
| Upper respiratory tract infection | 160.16 | 10.02 | 388 | 111847 | 130940 | 110346124 |
| Hand deformity | 149.10 | 10.02 | 22 | 112213 | 218484 | 110258580 |
| Sinus bradycardia | 148.43 | 10.02 | 166 | 112069 | 29317 | 110447747 |
| Pemphigus | 138.82 | 10.02 | 25 | 112210 | 214545 | 110262519 |
| Arthropathy | 135.56 | 10.02 | 61 | 112174 | 287461 | 110189603 |
| Anti-cyclic citrullinated peptide antibody positive | 129.68 | 10.02 | 16 | 112219 | 181968 | 110295096 |
| Accidental exposure to product by child | 127.11 | 10.02 | 63 | 112172 | 3135 | 110473929 |
| Systemic lupus erythematosus | 126.25 | 10.02 | 50 | 112185 | 254288 | 110222776 |
| Glossodynia | 125.30 | 10.02 | 35 | 112200 | 221969 | 110255095 |
| Pericarditis | 120.98 | 10.02 | 36 | 112199 | 219078 | 110257986 |
| Neovascularisation | 115.69 | 10.02 | 49 | 112186 | 1688 | 110475376 |
| Agitation | 115.03 | 10.02 | 312 | 111923 | 112739 | 110364325 |
| Paradoxical drug reaction | 111.52 | 10.02 | 87 | 112148 | 9730 | 110467334 |
| Cardiac arrest | 110.75 | 10.02 | 444 | 111791 | 196309 | 110280755 |
| Cerebrovascular accident | 110.08 | 10.02 | 419 | 111816 | 180865 | 110296199 |
| Duodenal ulcer perforation | 106.05 | 10.02 | 25 | 112210 | 177675 | 110299389 |
| Somnolence | 105.60 | 10.02 | 587 | 111648 | 296862 | 110180202 |
| Bursitis | 104.77 | 10.02 | 330 | 111905 | 129588 | 110347476 |
| Respiratory arrest | 102.85 | 10.02 | 200 | 112035 | 58099 | 110418965 |
| Sedation | 102.78 | 10.02 | 222 | 112013 | 69461 | 110407603 |
| Victim of child abuse | 100.54 | 10.02 | 40 | 112195 | 1171 | 110475893 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 98.61 | 10.02 | 64 | 112171 | 5353 | 110471711 |
| Lethargy | 96.95 | 10.02 | 260 | 111975 | 93316 | 110383748 |
| Poisoning | 96.71 | 10.02 | 133 | 112102 | 28972 | 110448092 |
| Constipation | 95.49 | 10.02 | 656 | 111579 | 357130 | 110119934 |
| Psoriatic arthropathy | 95.49 | 10.02 | 40 | 112195 | 196721 | 110280343 |
| Alopecia | 95.27 | 10.02 | 139 | 112096 | 364614 | 110112450 |
| Wound | 94.04 | 10.02 | 61 | 112174 | 234376 | 110242688 |
| Lower respiratory tract infection | 93.84 | 10.02 | 66 | 112169 | 243040 | 110234024 |
| Epidural lipomatosis | 92.01 | 10.02 | 44 | 112191 | 2023 | 110475041 |
| Oppositional defiant disorder | 91.86 | 10.02 | 30 | 112205 | 488 | 110476576 |
| Body tinea | 91.05 | 10.02 | 44 | 112191 | 2071 | 110474993 |
| Folliculitis | 89.93 | 10.02 | 29 | 112206 | 167624 | 110309440 |
| Neutropenia | 88.16 | 10.02 | 153 | 112082 | 374467 | 110102597 |
| Arthralgia | 87.80 | 10.02 | 450 | 111785 | 779182 | 109697882 |
| Blood pressure inadequately controlled | 87.48 | 10.02 | 68 | 112167 | 7565 | 110469499 |
| Prescribed overdose | 87.38 | 10.02 | 240 | 111995 | 87341 | 110389723 |
| Febrile neutropenia | 86.41 | 10.02 | 117 | 112118 | 316650 | 110160414 |
| Hypertensive emergency | 85.13 | 10.02 | 49 | 112186 | 3302 | 110473762 |
| Muscle injury | 83.64 | 10.02 | 20 | 112215 | 140787 | 110336277 |
| Nephrogenic systemic fibrosis | 83.53 | 10.02 | 58 | 112177 | 5425 | 110471639 |
| Impaired healing | 83.33 | 10.02 | 48 | 112187 | 196669 | 110280395 |
| Back pain | 81.21 | 10.02 | 649 | 111586 | 370347 | 110106717 |
| Myocardial infarction | 81.20 | 10.02 | 398 | 111837 | 191685 | 110285379 |
| Psychomotor hyperactivity | 80.29 | 10.02 | 101 | 112134 | 20176 | 110456888 |
| Irritable bowel syndrome | 78.69 | 10.02 | 34 | 112201 | 164181 | 110312883 |
| Miosis | 78.43 | 10.02 | 104 | 112131 | 21879 | 110455185 |
| C-reactive protein abnormal | 77.87 | 10.02 | 18 | 112217 | 129677 | 110347387 |
| Malignant neoplasm progression | 76.24 | 10.02 | 41 | 112194 | 174526 | 110302538 |
| Cardio-respiratory arrest | 73.84 | 10.02 | 272 | 111963 | 115564 | 110361500 |
| Helicobacter infection | 73.37 | 10.02 | 47 | 112188 | 181830 | 110295234 |
| Child abuse | 72.54 | 10.02 | 29 | 112206 | 860 | 110476204 |
| Rheumatoid factor positive | 71.97 | 10.02 | 22 | 112213 | 131618 | 110345446 |
| Malignant catatonia | 71.71 | 10.02 | 27 | 112208 | 679 | 110476385 |
| Interstitial lung disease | 69.76 | 10.02 | 27 | 112208 | 139307 | 110337757 |
| Blood pressure increased | 69.64 | 10.02 | 475 | 111760 | 257898 | 110219166 |
| Choreoathetosis | 69.12 | 10.02 | 34 | 112201 | 1664 | 110475400 |
| Poor quality sleep | 68.46 | 10.02 | 111 | 112124 | 27966 | 110449098 |
| Decreased eye contact | 68.31 | 10.02 | 28 | 112207 | 887 | 110476177 |
| Infection susceptibility increased | 68.12 | 10.02 | 47 | 112188 | 4351 | 110472713 |
| Swelling | 67.56 | 10.02 | 161 | 112074 | 350880 | 110126184 |
| Homicidal ideation | 66.38 | 10.02 | 43 | 112192 | 3584 | 110473480 |
| Unresponsive to stimuli | 64.82 | 10.02 | 176 | 112059 | 63614 | 110413450 |
| Gastrointestinal disorder | 64.33 | 10.02 | 91 | 112144 | 241861 | 110235203 |
| Hypertensive encephalopathy | 63.90 | 10.02 | 29 | 112206 | 1182 | 110475882 |
| Inhibitory drug interaction | 63.15 | 10.02 | 47 | 112188 | 4900 | 110472164 |
| Rheumatic fever | 62.62 | 10.02 | 23 | 112212 | 122556 | 110354508 |
| Therapeutic product effect decreased | 60.96 | 10.02 | 96 | 112139 | 244220 | 110232844 |
| C-reactive protein increased | 60.93 | 10.02 | 79 | 112156 | 217840 | 110259224 |
| Intentional product use issue | 60.36 | 10.02 | 99 | 112136 | 247807 | 110229257 |
| Discomfort | 59.86 | 10.02 | 78 | 112157 | 214629 | 110262435 |
| Nasopharyngitis | 59.60 | 10.02 | 203 | 112032 | 394158 | 110082906 |
| Suicidal ideation | 56.88 | 10.02 | 217 | 112018 | 93720 | 110383344 |
| Hypertensive urgency | 55.71 | 10.02 | 26 | 112209 | 1131 | 110475933 |
| Dystonia | 54.92 | 10.02 | 96 | 112139 | 25709 | 110451355 |
| Irritability | 54.80 | 10.02 | 138 | 112097 | 47671 | 110429393 |
| Accidental overdose | 54.66 | 10.02 | 145 | 112090 | 51689 | 110425375 |
| Implant site extravasation | 54.66 | 10.02 | 24 | 112211 | 904 | 110476160 |
| Distributive shock | 53.76 | 10.02 | 46 | 112189 | 5858 | 110471206 |
| Facet joint syndrome | 53.26 | 10.02 | 16 | 112219 | 96812 | 110380252 |
| Glucose tolerance impaired | 52.30 | 10.02 | 57 | 112178 | 9780 | 110467284 |
| Inflammation | 52.04 | 10.02 | 72 | 112163 | 193166 | 110283898 |
| Application site pruritus | 51.94 | 10.02 | 39 | 112196 | 4121 | 110472943 |
| Maternal exposure during pregnancy | 51.36 | 10.02 | 114 | 112121 | 254769 | 110222295 |
| Seizure | 51.14 | 10.02 | 392 | 111843 | 220793 | 110256271 |
| Product tampering | 51.14 | 10.02 | 19 | 112216 | 460 | 110476604 |
| Liver disorder | 50.55 | 10.02 | 42 | 112193 | 142201 | 110334863 |
| Blood prolactin increased | 50.28 | 10.02 | 40 | 112195 | 4602 | 110472462 |
| Ill-defined disorder | 50.19 | 10.02 | 51 | 112184 | 156802 | 110320262 |
| General physical health deterioration | 49.76 | 10.02 | 242 | 111993 | 425053 | 110052011 |
| Toxic epidermal necrolysis | 49.35 | 10.02 | 148 | 112087 | 56579 | 110420485 |
| Catatonia | 49.12 | 10.02 | 59 | 112176 | 11241 | 110465823 |
| Juvenile idiopathic arthritis | 49.07 | 10.02 | 44 | 112191 | 5963 | 110471101 |
| Hepatic function abnormal | 48.67 | 10.02 | 15 | 112220 | 89280 | 110387784 |
| Hyperaesthesia | 48.47 | 10.02 | 67 | 112168 | 14660 | 110462404 |
| Application site irritation | 48.35 | 10.02 | 28 | 112207 | 1909 | 110475155 |
| Neutrophil count decreased | 47.76 | 10.02 | 32 | 112203 | 120909 | 110356155 |
| Peritonitis bacterial | 47.44 | 10.02 | 56 | 112179 | 10477 | 110466587 |
| Product use issue | 47.24 | 10.02 | 504 | 111731 | 311191 | 110165873 |
| Dissociation | 47.13 | 10.02 | 54 | 112181 | 9788 | 110467276 |
| Brain injury | 46.92 | 10.02 | 63 | 112172 | 13413 | 110463651 |
| Decreased immune responsiveness | 46.49 | 10.02 | 53 | 112182 | 9553 | 110467511 |
| Dyskinesia | 46.44 | 10.02 | 136 | 112099 | 51310 | 110425754 |
| Abdominal discomfort | 46.14 | 10.02 | 224 | 112011 | 393634 | 110083430 |
| Musculoskeletal stiffness | 45.77 | 10.02 | 139 | 112096 | 279683 | 110197381 |
| Trismus | 45.55 | 10.02 | 44 | 112191 | 6552 | 110470512 |
| Depressed level of consciousness | 45.55 | 10.02 | 230 | 112005 | 112048 | 110365016 |
| Drug ineffective for unapproved indication | 45.53 | 10.02 | 216 | 112019 | 102622 | 110374442 |
| Crying | 45.29 | 10.02 | 88 | 112147 | 25540 | 110451524 |
| Application site rash | 44.73 | 10.02 | 29 | 112206 | 2421 | 110474643 |
| Diarrhoea | 44.56 | 10.02 | 852 | 111383 | 1138653 | 109338411 |
| Condition aggravated | 43.76 | 10.02 | 506 | 111729 | 734330 | 109742734 |
| Disease progression | 43.76 | 10.02 | 116 | 112119 | 243918 | 110233146 |
| Medical device site pain | 43.39 | 10.02 | 16 | 112219 | 379 | 110476685 |
| Left ventricular hypertrophy | 43.21 | 10.02 | 60 | 112175 | 13184 | 110463880 |
| Intentional overdose | 42.07 | 10.02 | 254 | 111981 | 132247 | 110344817 |
| Product prescribing error | 41.92 | 10.02 | 131 | 112104 | 51200 | 110425864 |
| Asthma | 41.87 | 10.02 | 413 | 111822 | 249878 | 110227186 |
| Anal inflammation | 41.81 | 10.02 | 28 | 112207 | 2468 | 110474596 |
| Pulmonary fibrosis | 41.65 | 10.02 | 26 | 112209 | 102016 | 110375048 |
| Arthritis | 41.65 | 10.02 | 66 | 112169 | 167520 | 110309544 |
| Lip dry | 41.55 | 10.02 | 25 | 112210 | 100058 | 110377006 |
| Anxiety | 41.21 | 10.02 | 533 | 111702 | 344545 | 110132519 |
| Lung disorder | 40.99 | 10.02 | 75 | 112160 | 179972 | 110297092 |
| Drug screen positive | 40.99 | 10.02 | 41 | 112194 | 6369 | 110470695 |
| Neuroleptic malignant syndrome | 40.82 | 10.02 | 100 | 112135 | 33959 | 110443105 |
| Peripheral swelling | 40.56 | 10.02 | 242 | 111993 | 403792 | 110073272 |
| Kidney transplant rejection | 40.15 | 10.02 | 55 | 112180 | 11932 | 110465132 |
| Cytokine release syndrome | 39.80 | 10.02 | 11 | 112224 | 70295 | 110406769 |
| Product substitution issue | 39.31 | 10.02 | 78 | 112157 | 22983 | 110454081 |
| Extrapyramidal disorder | 39.21 | 10.02 | 89 | 112146 | 28778 | 110448286 |
| Tardive dyskinesia | 39.14 | 10.02 | 58 | 112177 | 13521 | 110463543 |
| White blood cell count decreased | 38.92 | 10.02 | 112 | 112123 | 229278 | 110247786 |
| Intestinal angioedema | 38.88 | 10.02 | 20 | 112215 | 1077 | 110475987 |
| Acute motor-sensory axonal neuropathy | 38.59 | 10.02 | 16 | 112219 | 522 | 110476542 |
| Loss of consciousness | 38.40 | 10.02 | 335 | 111900 | 195971 | 110281093 |
| SARS-CoV-2 test negative | 38.12 | 10.02 | 25 | 112210 | 2128 | 110474936 |
| Mobility decreased | 38.07 | 10.02 | 119 | 112116 | 237303 | 110239761 |
| Emotional distress | 38.06 | 10.02 | 116 | 112119 | 44731 | 110432333 |
| Night sweats | 38.03 | 10.02 | 48 | 112187 | 133935 | 110343129 |
| Erythema | 37.72 | 10.02 | 457 | 111778 | 290990 | 110186074 |
| Bruxism | 37.70 | 10.02 | 35 | 112200 | 4959 | 110472105 |
| Apnoea | 37.53 | 10.02 | 57 | 112178 | 13582 | 110463482 |
| Swollen joint count increased | 37.48 | 10.02 | 19 | 112216 | 83642 | 110393422 |
| Wheezing | 37.44 | 10.02 | 133 | 112102 | 255097 | 110221967 |
| Coronary artery disease | 37.31 | 10.02 | 158 | 112077 | 71532 | 110405532 |
| COVID-19 | 37.10 | 10.02 | 126 | 112109 | 244934 | 110232130 |
| Malignant hypertension | 36.33 | 10.02 | 22 | 112213 | 1629 | 110475435 |
| Pneumonia | 36.25 | 10.02 | 649 | 111586 | 876065 | 109600999 |
| Gastrointestinal tract mucosal pigmentation | 36.03 | 10.02 | 20 | 112215 | 1257 | 110475807 |
| Akathisia | 35.55 | 10.02 | 63 | 112172 | 17050 | 110460014 |
| Breast cancer stage III | 35.40 | 10.02 | 18 | 112217 | 79099 | 110397965 |
| Anuria | 35.26 | 10.02 | 77 | 112158 | 24264 | 110452800 |
| Acute myocardial infarction | 34.95 | 10.02 | 173 | 112062 | 83604 | 110393460 |
| Claustrophobia | 34.64 | 10.02 | 21 | 112214 | 1558 | 110475506 |
| Application site erythema | 34.26 | 10.02 | 35 | 112200 | 5575 | 110471489 |
| Aplastic anaemia | 34.19 | 10.02 | 76 | 112159 | 24232 | 110452832 |
| Sinusitis | 33.43 | 10.02 | 171 | 112064 | 296517 | 110180547 |
| Joint swelling | 33.38 | 10.02 | 288 | 111947 | 442557 | 110034507 |
| Hypoventilation | 33.19 | 10.02 | 41 | 112194 | 8040 | 110469024 |
| Blister | 33.01 | 10.02 | 119 | 112116 | 227257 | 110249807 |
| Rash | 32.59 | 10.02 | 612 | 111623 | 820352 | 109656712 |
| Osteoarthritis | 32.59 | 10.02 | 87 | 112148 | 182536 | 110294528 |
| Hypothermia | 32.34 | 10.02 | 78 | 112157 | 26224 | 110450840 |
| Mucosal erosion | 32.02 | 10.02 | 25 | 112210 | 2799 | 110474265 |
| Retching | 32 | 10.02 | 71 | 112164 | 22611 | 110454453 |
| Hepatitis | 31.49 | 10.02 | 27 | 112208 | 90027 | 110387037 |
| Hypotonia | 31.48 | 10.02 | 57 | 112178 | 15688 | 110461376 |
| Joint range of motion decreased | 31.21 | 10.02 | 47 | 112188 | 121785 | 110355279 |
| Peripheral venous disease | 30.93 | 10.02 | 24 | 112211 | 84093 | 110392971 |
| Grip strength decreased | 30.61 | 10.02 | 22 | 112213 | 80152 | 110396912 |
| Serotonin syndrome | 30.50 | 10.02 | 130 | 112105 | 59023 | 110418041 |
| Pancytopenia | 30.23 | 10.02 | 110 | 112125 | 209503 | 110267561 |
| Posterior reversible encephalopathy syndrome | 30.07 | 10.02 | 89 | 112146 | 33772 | 110443292 |
| Skin hypertrophy | 29.94 | 10.02 | 31 | 112204 | 5016 | 110472048 |
| Pneumocystis jirovecii pneumonia | 29.84 | 10.02 | 4 | 112231 | 42731 | 110434333 |
| Colitis ulcerative | 29.84 | 10.02 | 21 | 112214 | 77342 | 110399722 |
| Skin induration | 29.75 | 10.02 | 29 | 112206 | 4366 | 110472698 |
| Adulterated product | 29.64 | 10.02 | 17 | 112218 | 1138 | 110475926 |
| Malaise | 29.45 | 10.02 | 492 | 111743 | 671327 | 109805737 |
| Live birth | 29.35 | 10.02 | 17 | 112218 | 69467 | 110407597 |
| Tremor | 29.23 | 10.02 | 324 | 111911 | 201908 | 110275156 |
| Urinary incontinence | 29.21 | 10.02 | 112 | 112123 | 48475 | 110428589 |
| Blood cholesterol increased | 28.65 | 10.02 | 94 | 112141 | 184691 | 110292373 |
| Anhedonia | 28.52 | 10.02 | 54 | 112181 | 15374 | 110461690 |
| Blepharospasm | 28.51 | 10.02 | 10 | 112225 | 54841 | 110422223 |
| Osteonecrosis of jaw | 28.16 | 10.02 | 7 | 112228 | 48010 | 110429054 |
| Product compounding quality issue | 27.97 | 10.02 | 7 | 112228 | 40 | 110477024 |
| Psoriasis | 27.95 | 10.02 | 240 | 111995 | 139753 | 110337311 |
| Taste disorder | 27.61 | 10.02 | 16 | 112219 | 65371 | 110411693 |
| Anger | 27.38 | 10.02 | 60 | 112175 | 18947 | 110458117 |
| Hyperreflexia | 26.61 | 10.02 | 40 | 112195 | 9445 | 110467619 |
| Productive cough | 26.56 | 10.02 | 47 | 112188 | 114258 | 110362806 |
| Product adhesion issue | 26.52 | 10.02 | 23 | 112212 | 2983 | 110474081 |
| Oromandibular dystonia | 26.20 | 10.02 | 16 | 112219 | 1203 | 110475861 |
| Dialysis | 26.10 | 10.02 | 60 | 112175 | 19559 | 110457505 |
| Chronic kidney disease | 25.99 | 10.02 | 149 | 112086 | 76142 | 110400922 |
| Abnormal behaviour | 25.99 | 10.02 | 93 | 112142 | 38946 | 110438118 |
| Medical device site discharge | 25.93 | 10.02 | 7 | 112228 | 56 | 110477008 |
| Epilepsy with myoclonic-atonic seizures | 25.87 | 10.02 | 8 | 112227 | 108 | 110476956 |
| Nodal rhythm | 25.86 | 10.02 | 24 | 112211 | 3399 | 110473665 |
| Feeling of despair | 25.60 | 10.02 | 25 | 112210 | 3773 | 110473291 |
| Pulse abnormal | 25.55 | 10.02 | 26 | 112209 | 4123 | 110472941 |
| Tic | 25.45 | 10.02 | 24 | 112211 | 3469 | 110473595 |
| Overweight | 25.27 | 10.02 | 32 | 112203 | 6432 | 110470632 |
| Hyperlipidaemia | 25.24 | 10.02 | 87 | 112148 | 35761 | 110441303 |
| Liver injury | 25.10 | 10.02 | 74 | 112161 | 150339 | 110326725 |
| Autonomic nervous system imbalance | 24.83 | 10.02 | 30 | 112205 | 5750 | 110471314 |
| Basal ganglion degeneration | 24.79 | 10.02 | 11 | 112224 | 425 | 110476639 |
| Bone density decreased | 24.67 | 10.02 | 52 | 112183 | 15990 | 110461074 |
| Device power source issue | 24.62 | 10.02 | 16 | 112219 | 1341 | 110475723 |
| Anaesthesia | 24.31 | 10.02 | 12 | 112223 | 592 | 110476472 |
| Neoplasm progression | 24.30 | 10.02 | 18 | 112217 | 64577 | 110412487 |
| Device infusion issue | 24.27 | 10.02 | 22 | 112213 | 3023 | 110474041 |
| Mood swings | 24.24 | 10.02 | 64 | 112171 | 22748 | 110454316 |
| Loss of personal independence in daily activities | 24.18 | 10.02 | 75 | 112160 | 149945 | 110327119 |
| Device failure | 24.04 | 10.02 | 33 | 112202 | 7174 | 110469890 |
| Rash maculo-papular | 23.89 | 10.02 | 24 | 112211 | 74198 | 110402866 |
| Attention deficit hyperactivity disorder | 23.83 | 10.02 | 26 | 112209 | 4465 | 110472599 |
| Somatic symptom disorder | 23.58 | 10.02 | 22 | 112213 | 3137 | 110473927 |
| Stomatitis | 23.49 | 10.02 | 169 | 112066 | 270073 | 110206991 |
| Acute myeloid leukaemia | 23.45 | 10.02 | 5 | 112230 | 38105 | 110438959 |
| Pain | 23.25 | 10.02 | 1188 | 111047 | 953767 | 109523297 |
| Musculoskeletal pain | 22.64 | 10.02 | 102 | 112133 | 182921 | 110294143 |
| Fibromyalgia | 22.51 | 10.02 | 93 | 112142 | 170816 | 110306248 |
| Abdominal pain upper | 22.48 | 10.02 | 236 | 111999 | 348875 | 110128189 |
| Sleep disorder due to general medical condition, insomnia type | 22.31 | 10.02 | 46 | 112189 | 105597 | 110371467 |
| Cytomegalovirus infection | 22.04 | 10.02 | 14 | 112221 | 54430 | 110422634 |
| Medication error | 21.75 | 10.02 | 182 | 112053 | 105184 | 110371880 |
| Platelet count decreased | 21.56 | 10.02 | 141 | 112094 | 230302 | 110246762 |
| Speech disorder | 21.47 | 10.02 | 121 | 112114 | 61448 | 110415616 |
| Drug eruption | 21.45 | 10.02 | 14 | 112221 | 53645 | 110423419 |
| Haematochezia | 21.40 | 10.02 | 54 | 112181 | 115470 | 110361594 |
| Treatment noncompliance | 21.33 | 10.02 | 137 | 112098 | 72853 | 110404211 |
| Drooling | 21.31 | 10.02 | 31 | 112204 | 7108 | 110469956 |
| Impaired quality of life | 21.27 | 10.02 | 73 | 112162 | 29944 | 110447120 |
| Drug interaction | 21.24 | 10.02 | 661 | 111574 | 499522 | 109977542 |
| Neutropenic sepsis | 21.18 | 10.02 | 3 | 112232 | 30743 | 110446321 |
| Accelerated hypertension | 21.17 | 10.02 | 12 | 112223 | 785 | 110476279 |
| Injection site abscess | 21.12 | 10.02 | 17 | 112218 | 1989 | 110475075 |
| Accident | 21.07 | 10.02 | 39 | 112196 | 10913 | 110466151 |
| Frequent bowel movements | 20.86 | 10.02 | 25 | 112210 | 71365 | 110405699 |
| Epilepsy | 20.85 | 10.02 | 44 | 112191 | 100165 | 110376899 |
| Atrioventricular block second degree | 20.84 | 10.02 | 33 | 112202 | 8148 | 110468916 |
| Renin decreased | 20.78 | 10.02 | 7 | 112228 | 126 | 110476938 |
| Systolic dysfunction | 20.76 | 10.02 | 24 | 112211 | 4391 | 110472673 |
| Reaction to excipient | 20.73 | 10.02 | 17 | 112218 | 2042 | 110475022 |
| Blood aldosterone increased | 20.61 | 10.02 | 8 | 112227 | 219 | 110476845 |
| Intestinal pseudo-obstruction | 20.61 | 10.02 | 21 | 112214 | 3335 | 110473729 |
| Application site discolouration | 20.60 | 10.02 | 13 | 112222 | 1036 | 110476028 |
| Renal artery stenosis | 20.52 | 10.02 | 22 | 112213 | 3704 | 110473360 |
| Implant site infection | 20.41 | 10.02 | 17 | 112218 | 2086 | 110474978 |
| Urticaria | 19.94 | 10.02 | 217 | 112018 | 318640 | 110158424 |
| Hepatic cytolysis | 19.87 | 10.02 | 16 | 112219 | 55037 | 110422027 |
| Implant site pain | 19.64 | 10.02 | 17 | 112218 | 2198 | 110474866 |
| Onychomadesis | 19.53 | 10.02 | 11 | 112224 | 45652 | 110431412 |
| Nail disorder | 19.50 | 10.02 | 18 | 112217 | 57917 | 110419147 |
| Renal transplant | 19.41 | 10.02 | 20 | 112215 | 3218 | 110473846 |
| Eczema | 19.39 | 10.02 | 27 | 112208 | 72266 | 110404798 |
| Fibrous dysplasia of jaw | 19.19 | 10.02 | 4 | 112231 | 8 | 110477056 |
| Coma scale abnormal | 19.18 | 10.02 | 35 | 112200 | 9691 | 110467373 |
| Norepinephrine increased | 19.07 | 10.02 | 6 | 112229 | 86 | 110476978 |
| Alanine aminotransferase increased | 18.99 | 10.02 | 109 | 112126 | 183664 | 110293400 |
| Primary hyperaldosteronism | 18.99 | 10.02 | 8 | 112227 | 272 | 110476792 |
| Respiratory tract infection | 18.96 | 10.02 | 27 | 112208 | 71590 | 110405474 |
| Mood altered | 18.81 | 10.02 | 56 | 112179 | 21319 | 110455745 |
| Hypercholesterolaemia | 18.80 | 10.02 | 40 | 112195 | 90797 | 110386267 |
| Vascular stenosis | 18.77 | 10.02 | 11 | 112224 | 767 | 110476297 |
| Sympathomimetic effect | 18.67 | 10.02 | 7 | 112228 | 174 | 110476890 |
| Retrograde amnesia | 18.65 | 10.02 | 11 | 112224 | 776 | 110476288 |
| Electrocardiogram QRS complex prolonged | 18.64 | 10.02 | 41 | 112194 | 12980 | 110464084 |
| Restlessness | 18.59 | 10.02 | 109 | 112126 | 56150 | 110420914 |
| Product administered to patient of inappropriate age | 18.55 | 10.02 | 31 | 112204 | 8005 | 110469059 |
| Bronchiectasis | 18.38 | 10.02 | 7 | 112228 | 36486 | 110440578 |
| Drug abuse | 18.29 | 10.02 | 267 | 111968 | 177144 | 110299920 |
| Injection site erythema | 18.24 | 10.02 | 43 | 112192 | 94133 | 110382931 |
| Tissue infiltration | 18.20 | 10.02 | 12 | 112223 | 1031 | 110476033 |
| Croup infectious | 18.12 | 10.02 | 12 | 112223 | 1038 | 110476026 |
| Muscle contracture | 18.03 | 10.02 | 18 | 112217 | 2790 | 110474274 |
| Wound infection | 17.94 | 10.02 | 45 | 112190 | 96420 | 110380644 |
| Drug withdrawal headache | 17.91 | 10.02 | 6 | 112229 | 106 | 110476958 |
| Prostate cancer | 17.70 | 10.02 | 8 | 112227 | 37633 | 110439431 |
| Agranulocytosis | 17.65 | 10.02 | 22 | 112213 | 61738 | 110415326 |
| Therapeutic product effect incomplete | 17.54 | 10.02 | 144 | 112091 | 223661 | 110253403 |
| Rhabdomyolysis | 17.43 | 10.02 | 193 | 112042 | 120208 | 110356856 |
| Renal injury | 17.40 | 10.02 | 50 | 112185 | 18663 | 110458401 |
| Autism spectrum disorder | 17.38 | 10.02 | 15 | 112220 | 1933 | 110475131 |
| Electrocardiogram QT prolonged | 17.34 | 10.02 | 178 | 112057 | 108782 | 110368282 |
| Atrioventricular block first degree | 17.29 | 10.02 | 42 | 112193 | 14183 | 110462881 |
| Bone marrow failure | 17.18 | 10.02 | 20 | 112215 | 57828 | 110419236 |
| Iliac artery stenosis | 17.04 | 10.02 | 7 | 112228 | 223 | 110476841 |
| Purpura | 17.01 | 10.02 | 59 | 112176 | 24329 | 110452735 |
| Pruritus | 16.91 | 10.02 | 455 | 111780 | 581105 | 109895959 |
| Infusion site mass | 16.84 | 10.02 | 14 | 112221 | 1714 | 110475350 |
| Cancer pain | 16.82 | 10.02 | 27 | 112208 | 6745 | 110470319 |
| Type 2 diabetes mellitus | 16.80 | 10.02 | 108 | 112127 | 177124 | 110299940 |
| Medical device site infection | 16.78 | 10.02 | 10 | 112225 | 719 | 110476345 |
| Lymphopenia | 16.72 | 10.02 | 10 | 112225 | 40160 | 110436904 |
| Pulse absent | 16.67 | 10.02 | 36 | 112199 | 11256 | 110465808 |
| Abortion spontaneous | 16.57 | 10.02 | 7 | 112228 | 34275 | 110442789 |
| Hypoxic-ischaemic encephalopathy | 16.39 | 10.02 | 31 | 112204 | 8816 | 110468248 |
| Uterine enlargement | 16.38 | 10.02 | 11 | 112224 | 974 | 110476090 |
| Incision site pain | 16.38 | 10.02 | 18 | 112217 | 3117 | 110473947 |
| Tachycardia | 16.38 | 10.02 | 322 | 111913 | 226323 | 110250741 |
| Feeling abnormal | 16.34 | 10.02 | 266 | 111969 | 180445 | 110296619 |
| Pernicious anaemia | 16.23 | 10.02 | 10 | 112225 | 764 | 110476300 |
| Hyperkinesia | 16.15 | 10.02 | 18 | 112217 | 3166 | 110473898 |
| Mast cell degranulation present | 16.13 | 10.02 | 5 | 112230 | 68 | 110476996 |
| Pain in jaw | 15.96 | 10.02 | 17 | 112218 | 51160 | 110425904 |
| Pathergy reaction | 15.87 | 10.02 | 5 | 112230 | 72 | 110476992 |
| Secondary hypertension | 15.81 | 10.02 | 9 | 112226 | 594 | 110476470 |
| Genital erosion | 15.80 | 10.02 | 10 | 112225 | 801 | 110476263 |
| Affective disorder | 15.65 | 10.02 | 35 | 112200 | 11206 | 110465858 |
| Pneumonitis | 15.59 | 10.02 | 34 | 112201 | 76497 | 110400567 |
| Blood potassium increased | 15.57 | 10.02 | 71 | 112164 | 33178 | 110443886 |
| Change in seizure presentation | 15.54 | 10.02 | 10 | 112225 | 824 | 110476240 |
| Application site papules | 15.50 | 10.02 | 5 | 112230 | 78 | 110476986 |
| Rheumatoid arthritis | 15.49 | 10.02 | 406 | 111829 | 299207 | 110177857 |
| Renal tubular atrophy | 15.37 | 10.02 | 15 | 112220 | 2261 | 110474803 |
| Galactorrhoea | 15.35 | 10.02 | 20 | 112215 | 4135 | 110472929 |
| Melaena | 15.32 | 10.02 | 29 | 112206 | 68728 | 110408336 |
| Basal cell carcinoma | 15.31 | 10.02 | 14 | 112221 | 45256 | 110431808 |
| Implant site discharge | 15.26 | 10.02 | 6 | 112229 | 170 | 110476894 |
| Colitis | 15.21 | 10.02 | 53 | 112182 | 102270 | 110374794 |
| Respiratory moniliasis | 15.07 | 10.02 | 8 | 112227 | 460 | 110476604 |
| Deep vein thrombosis postoperative | 15.06 | 10.02 | 23 | 112212 | 59268 | 110417796 |
| Infection | 14.95 | 10.02 | 268 | 111967 | 361932 | 110115132 |
| Pulmonary oedema | 14.87 | 10.02 | 162 | 112073 | 100497 | 110376567 |
| Skin tightness | 14.80 | 10.02 | 23 | 112212 | 5590 | 110471474 |
| Pregnancy | 14.80 | 10.02 | 18 | 112217 | 51049 | 110426015 |
| Drug-induced liver injury | 14.79 | 10.02 | 67 | 112168 | 120000 | 110357064 |
| Pulmonary embolism | 14.61 | 10.02 | 143 | 112092 | 214331 | 110262733 |
| Infusion related reaction | 14.51 | 10.02 | 286 | 111949 | 380876 | 110096188 |
| Catheter site granuloma | 14.49 | 10.02 | 5 | 112230 | 97 | 110476967 |
| Kidney fibrosis | 14.48 | 10.02 | 20 | 112215 | 4372 | 110472692 |
| Feeling of body temperature change | 14.46 | 10.02 | 24 | 112211 | 6164 | 110470900 |
| Fibrosis | 14.44 | 10.02 | 27 | 112208 | 7615 | 110469449 |
| Vision blurred | 14.43 | 10.02 | 197 | 112038 | 128825 | 110348239 |
| Human ehrlichiosis | 14.39 | 10.02 | 9 | 112226 | 706 | 110476358 |
| Haemophagocytic lymphohistiocytosis | 14.39 | 10.02 | 7 | 112228 | 31552 | 110445512 |
| Drug ineffective | 14.38 | 10.02 | 1757 | 110478 | 1518783 | 108958281 |
| Impaired work ability | 14.35 | 10.02 | 59 | 112176 | 26360 | 110450704 |
| Respiratory rate decreased | 14.26 | 10.02 | 24 | 112211 | 6234 | 110470830 |
| Saccadic eye movement | 14.24 | 10.02 | 6 | 112229 | 204 | 110476860 |
| Breast cancer stage II | 14.21 | 10.02 | 5 | 112230 | 27370 | 110449694 |
| Obsessive-compulsive disorder | 14.20 | 10.02 | 26 | 112209 | 7215 | 110469849 |
| Sleep disorder | 14.15 | 10.02 | 131 | 112104 | 198513 | 110278551 |
| Sinus arrhythmia | 14.10 | 10.02 | 14 | 112221 | 2156 | 110474908 |
| Skin disorder | 14.09 | 10.02 | 83 | 112152 | 42830 | 110434234 |
| Chronic sinusitis | 14.06 | 10.02 | 4 | 112231 | 25080 | 110451984 |
| Headache | 14.04 | 10.02 | 1058 | 111177 | 881319 | 109595745 |
| Brief psychotic disorder with marked stressors | 14.04 | 10.02 | 7 | 112228 | 353 | 110476711 |
| Chest discomfort | 14.01 | 10.02 | 111 | 112124 | 173737 | 110303327 |
| Subdural effusion | 13.99 | 10.02 | 5 | 112230 | 108 | 110476956 |
| Joint injury | 13.97 | 10.02 | 12 | 112223 | 39982 | 110437082 |
| Peritoneal dialysis complication | 13.97 | 10.02 | 15 | 112220 | 2531 | 110474533 |
| BRASH syndrome | 13.88 | 10.02 | 18 | 112217 | 3705 | 110473359 |
| Glomerulonephritis rapidly progressive | 13.86 | 10.02 | 14 | 112221 | 2201 | 110474863 |
| Focal segmental glomerulosclerosis | 13.86 | 10.02 | 19 | 112216 | 4126 | 110472938 |
| Corneal reflex decreased | 13.82 | 10.02 | 8 | 112227 | 545 | 110476519 |
| Blood pressure decreased | 13.81 | 10.02 | 178 | 112057 | 114913 | 110362151 |
| Bone erosion | 13.80 | 10.02 | 16 | 112219 | 46355 | 110430709 |
| Product prescribing issue | 13.74 | 10.02 | 36 | 112199 | 12736 | 110464328 |
| Short-bowel syndrome | 13.71 | 10.02 | 9 | 112226 | 767 | 110476297 |
| Pyrexia | 13.66 | 10.02 | 759 | 111476 | 897506 | 109579558 |
| Inadequate analgesia | 13.66 | 10.02 | 21 | 112214 | 5056 | 110472008 |
| Exposure to allergen | 13.66 | 10.02 | 8 | 112227 | 557 | 110476507 |
| Death | 13.58 | 10.02 | 852 | 111383 | 698017 | 109779047 |
| Cardiac hypertrophy | 13.47 | 10.02 | 13 | 112222 | 1934 | 110475130 |
| Drug intolerance | 13.44 | 10.02 | 312 | 111923 | 406200 | 110070864 |
| Nervousness | 13.23 | 10.02 | 73 | 112162 | 36778 | 110440286 |
| Hypersomnia | 13.20 | 10.02 | 60 | 112175 | 28001 | 110449063 |
| Pulmonary renal syndrome | 13.05 | 10.02 | 9 | 112226 | 832 | 110476232 |
| Myoclonus | 12.96 | 10.02 | 67 | 112168 | 32931 | 110444133 |
| Gun shot wound | 12.95 | 10.02 | 10 | 112225 | 1102 | 110475962 |
| Blood bilirubin increased | 12.94 | 10.02 | 37 | 112198 | 75935 | 110401129 |
| Skin fibrosis | 12.93 | 10.02 | 11 | 112224 | 1389 | 110475675 |
| Onychomycosis | 12.93 | 10.02 | 12 | 112223 | 38519 | 110438545 |
| Product preparation issue | 12.89 | 10.02 | 15 | 112220 | 2764 | 110474300 |
| Supraventricular tachycardia | 12.84 | 10.02 | 54 | 112181 | 24368 | 110452696 |
| Fear | 12.76 | 10.02 | 52 | 112183 | 23141 | 110453923 |
| Anaemia | 12.71 | 10.02 | 441 | 111794 | 546645 | 109930419 |
| Toxic skin eruption | 12.70 | 10.02 | 6 | 112229 | 27509 | 110449555 |
| X-ray abnormal | 12.64 | 10.02 | 12 | 112223 | 38105 | 110438959 |
| Labelled drug-drug interaction medication error | 12.62 | 10.02 | 7 | 112228 | 29295 | 110447769 |
| Labile blood pressure | 12.58 | 10.02 | 14 | 112221 | 2457 | 110474607 |
| Hyperthyroidism | 12.58 | 10.02 | 7 | 112228 | 29254 | 110447810 |
| Mydriasis | 12.45 | 10.02 | 50 | 112185 | 22107 | 110454957 |
| Device expulsion | 12.43 | 10.02 | 8 | 112227 | 30883 | 110446181 |
| Liver function test increased | 12.41 | 10.02 | 47 | 112188 | 88501 | 110388563 |
| Peau d'orange | 12.38 | 10.02 | 6 | 112229 | 284 | 110476780 |
| Tumour lysis syndrome | 12.36 | 10.02 | 8 | 112227 | 30793 | 110446271 |
| Renal failure | 12.28 | 10.02 | 309 | 111926 | 226265 | 110250799 |
| Hyperbilirubinaemia | 12.26 | 10.02 | 8 | 112227 | 30663 | 110446401 |
| Transaminases increased | 12.23 | 10.02 | 29 | 112206 | 63361 | 110413703 |
| Hallucination | 12.22 | 10.02 | 157 | 112078 | 101275 | 110375789 |
| Hypervolaemia | 12.17 | 10.02 | 89 | 112146 | 49371 | 110427693 |
| Tracheostomy | 12.11 | 10.02 | 11 | 112224 | 1516 | 110475548 |
| Respiratory failure | 12.07 | 10.02 | 295 | 111940 | 215037 | 110262027 |
| Page kidney | 12.03 | 10.02 | 4 | 112231 | 69 | 110476995 |
| Maternal use of illicit drugs | 12.01 | 10.02 | 3 | 112232 | 17 | 110477047 |
| Trichostasis spinulosa | 12.01 | 10.02 | 3 | 112232 | 17 | 110477047 |
| C-reactive protein | 12.01 | 10.02 | 8 | 112227 | 30323 | 110446741 |
| Appendicitis | 11.97 | 10.02 | 7 | 112228 | 28457 | 110448607 |
| Therapeutic drug monitoring analysis incorrectly performed | 11.96 | 10.02 | 8 | 112227 | 704 | 110476360 |
| Respiratory acidosis | 11.95 | 10.02 | 36 | 112199 | 13790 | 110463274 |
| Gamma-glutamyltransferase increased | 11.87 | 10.02 | 28 | 112207 | 61281 | 110415783 |
| Bladder cancer | 11.82 | 10.02 | 3 | 112232 | 20289 | 110456775 |
| Implant site mass | 11.77 | 10.02 | 4 | 112231 | 74 | 110476990 |
| Osteoporosis | 11.74 | 10.02 | 47 | 112188 | 87105 | 110389959 |
| Autoimmune enteropathy | 11.72 | 10.02 | 4 | 112231 | 75 | 110476989 |
| Renal transplant failure | 11.66 | 10.02 | 14 | 112221 | 2666 | 110474398 |
| Rhinorrhoea | 11.65 | 10.02 | 59 | 112176 | 102607 | 110374457 |
| Aspartate aminotransferase increased | 11.59 | 10.02 | 105 | 112130 | 159831 | 110317233 |
| Medical device site erythema | 11.53 | 10.02 | 4 | 112231 | 79 | 110476985 |
| Screaming | 11.50 | 10.02 | 19 | 112216 | 4862 | 110472202 |
| Gait inability | 11.50 | 10.02 | 86 | 112149 | 136290 | 110340774 |
| Psychogenic seizure | 11.37 | 10.02 | 13 | 112222 | 2351 | 110474713 |
| Multiple sclerosis relapse | 11.36 | 10.02 | 21 | 112214 | 50219 | 110426845 |
| Rash pruritic | 11.33 | 10.02 | 56 | 112179 | 98013 | 110379051 |
| Foreign body reaction | 11.30 | 10.02 | 5 | 112230 | 192 | 110476872 |
| Uveitis | 11.21 | 10.02 | 4 | 112231 | 21706 | 110455358 |
| Hip arthroplasty | 11.20 | 10.02 | 25 | 112210 | 55788 | 110421276 |
| Delirium | 11.20 | 10.02 | 196 | 112039 | 134829 | 110342235 |
| Gastric ileus | 11.12 | 10.02 | 3 | 112232 | 24 | 110477040 |
| Medical device site swelling | 11.04 | 10.02 | 4 | 112231 | 90 | 110476974 |
| Paraesthesia | 10.97 | 10.02 | 206 | 112029 | 276315 | 110200749 |
| Drug clearance | 10.96 | 10.02 | 4 | 112231 | 92 | 110476972 |
| Alcoholism | 10.92 | 10.02 | 16 | 112219 | 3691 | 110473373 |
| Accidental poisoning | 10.83 | 10.02 | 13 | 112222 | 2474 | 110474590 |
| Retinopathy hypertensive | 10.83 | 10.02 | 7 | 112228 | 581 | 110476483 |
| Drug detoxification | 10.83 | 10.02 | 7 | 112228 | 581 | 110476483 |
| Stress cardiomyopathy | 10.82 | 10.02 | 38 | 112197 | 15768 | 110461296 |
| Joint contracture | 10.82 | 10.02 | 13 | 112222 | 2478 | 110474586 |
| Knee arthroplasty | 10.80 | 10.02 | 32 | 112203 | 64916 | 110412148 |
| Impulsive behaviour | 10.79 | 10.02 | 15 | 112220 | 3300 | 110473764 |
| Metastases to liver | 10.76 | 10.02 | 12 | 112223 | 35374 | 110441690 |
| Labile hypertension | 10.71 | 10.02 | 7 | 112228 | 592 | 110476472 |
| Drug resistance | 10.71 | 10.02 | 26 | 112209 | 56348 | 110420716 |
| Human herpesvirus 6 infection reactivation | 10.70 | 10.02 | 9 | 112226 | 1120 | 110475944 |
| Hypertrichosis | 10.69 | 10.02 | 11 | 112224 | 1767 | 110475297 |
| Cognitive disorder | 10.68 | 10.02 | 49 | 112186 | 87462 | 110389602 |
| Paranoia | 10.64 | 10.02 | 48 | 112187 | 22326 | 110454738 |
| Cerebellar atrophy | 10.62 | 10.02 | 10 | 112225 | 1443 | 110475621 |
| Blood pressure systolic abnormal | 10.61 | 10.02 | 6 | 112229 | 24844 | 110452220 |
| Sciatica | 10.54 | 10.02 | 53 | 112182 | 92346 | 110384718 |
| Graft versus host disease | 10.54 | 10.02 | 3 | 112232 | 18803 | 110458261 |
| Implant site hypersensitivity | 10.52 | 10.02 | 3 | 112232 | 30 | 110477034 |
| Hepatitis acute | 10.50 | 10.02 | 3 | 112232 | 18763 | 110458301 |
| Psychotic symptom | 10.41 | 10.02 | 16 | 112219 | 3851 | 110473213 |
| Hyperthermia | 10.39 | 10.02 | 46 | 112189 | 21226 | 110455838 |
| Pulseless electrical activity | 10.38 | 10.02 | 39 | 112196 | 16718 | 110460346 |
| Encephalomalacia | 10.34 | 10.02 | 10 | 112225 | 1492 | 110475572 |
| Foot deformity | 10.33 | 10.02 | 21 | 112214 | 48459 | 110428605 |
| Rhinitis | 10.28 | 10.02 | 5 | 112230 | 22540 | 110454524 |
| Metastases to bone | 10.26 | 10.02 | 10 | 112225 | 31362 | 110445702 |
| Adrenal insufficiency | 10.24 | 10.02 | 17 | 112218 | 42373 | 110434691 |
| Prescribed underdose | 10.20 | 10.02 | 33 | 112202 | 65141 | 110411923 |
| Chloasma | 10.19 | 10.02 | 4 | 112231 | 113 | 110476951 |
| Cerebral atrophy | 10.18 | 10.02 | 26 | 112209 | 9059 | 110468005 |
| Tendonitis | 10.16 | 10.02 | 7 | 112228 | 26076 | 110450988 |
| Intercepted medication error | 10.12 | 10.02 | 9 | 112226 | 1207 | 110475857 |
| Postoperative hypertension | 10.10 | 10.02 | 3 | 112232 | 35 | 110477029 |
| Device computer issue | 10.09 | 10.02 | 4 | 112231 | 116 | 110476948 |
| Blood creatinine increased | 10.08 | 10.02 | 250 | 111985 | 182639 | 110294425 |
| Right ventricular failure | 10.07 | 10.02 | 7 | 112228 | 25947 | 110451117 |
| Red blood cell sedimentation rate increased | 10.07 | 10.02 | 43 | 112192 | 78259 | 110398805 |
| Product preparation error | 10.05 | 10.02 | 29 | 112206 | 10850 | 110466214 |
| Streptococcal infection | 10.03 | 10.02 | 29 | 112206 | 10861 | 110466203 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C02AC01 | CARDIOVASCULAR SYSTEM ANTIHYPERTENSIVES ANTIADRENERGIC AGENTS, CENTRALLY ACTING Imidazoline receptor agonists |
| ATC | C02LC01 | CARDIOVASCULAR SYSTEM ANTIHYPERTENSIVES ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION Imidazoline receptor agonists in combination with diuretics |
| ATC | C02LC51 | CARDIOVASCULAR SYSTEM ANTIHYPERTENSIVES ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION Imidazoline receptor agonists in combination with diuretics |
| ATC | N02CX02 | NERVOUS SYSTEM ANALGESICS ANTIMIGRAINE PREPARATIONS Other antimigraine preparations |
| ATC | S01EA04 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Sympathomimetics in glaucoma therapy |
| FDA MoA | N0000009918 | Adrenergic alpha2-Agonists |
| FDA EPC | N0000175554 | Central alpha-2 Adrenergic Agonist |
| MeSH PA | D000316 | Adrenergic alpha-Agonists |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D013565 | Sympatholytics |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D018689 | Sensory System Agents |
| MeSH PA | D058647 | Adrenergic alpha-2 Receptor Agonists |
| CHEBI has role | CHEBI:35481 | non-narcotic analgesic |
| CHEBI has role | CHEBI:35569 | ฮฑ-adrenergic agonist |
| CHEBI has role | CHEBI:35674 | antihypertensive agent |
| CHEBI has role | CHEBI:66991 | sympatholytic agent |
Related Drugs by ATC class:
C02AC Imidazoline receptor agonists 4 drugs
C02LC Imidazoline receptor agonists in combination with diuretics 1 drug
N02CX Other antimigraine preparations 4 drugs
S01EA Sympathomimetics in glaucoma therapy 5 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
| Severe pain | indication | 76948002 | |
| Open-angle glaucoma | indication | 84494001 | DOID:1067 |
| Attention deficit hyperactivity disorder | indication | 406506008 | |
| Increased Intraocular Pressure after Ocular Procedure | indication | ||
| Ocular hypertension | off-label use | 4210003 | DOID:9282 |
| Gilles de la Tourette's syndrome | off-label use | 5158005 | DOID:11119 |
| Pain | off-label use | 22253000 | |
| Diarrhea | off-label use | 62315008 | |
| Opioid withdrawal | off-label use | 87132004 | |
| Menopausal flushing | off-label use | 198436008 | |
| Smoking cessation assistance | off-label use | 384742004 | |
| Nicotine Withdrawal Symptoms | off-label use | ||
| Anuria | contraindication | 2472002 | DOID:2983 |
| Hypercholesterolemia | contraindication | 13644009 | |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Depressive disorder | contraindication | 35489007 | |
| Hyperuricemia | contraindication | 35885006 | DOID:1920 |
| Hypokalemia | contraindication | 43339004 | |
| Diabetes mellitus type 2 | contraindication | 44054006 | DOID:9352 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Low blood pressure | contraindication | 45007003 | |
| Tear film insufficiency | contraindication | 46152009 | |
| End stage renal disease | contraindication | 46177005 | DOID:784 |
| Diabetes mellitus type 1 | contraindication | 46635009 | DOID:9744 |
| Bradycardia | contraindication | 48867003 | |
| Sinus bradycardia | contraindication | 49710005 | |
| Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
| Sympathectomy | contraindication | 57071006 | |
| Acute nephropathy | contraindication | 58574008 | |
| Hepatic failure | contraindication | 59927004 | |
| Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Hypercalcemia | contraindication | 66931009 | DOID:12678 |
| Hypochloremic alkalosis | contraindication | 70134007 | |
| Decreased respiratory function | contraindication | 80954004 | |
| Oliguria | contraindication | 83128009 | |
| Hyponatremia | contraindication | 89627008 | |
| Gout | contraindication | 90560007 | DOID:13189 |
| Magnetic resonance imaging | contraindication | 113091000 | |
| Perioperative care | contraindication | 133897009 | |
| Hypomagnesemia | contraindication | 190855004 | |
| Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
| Atrioventricular block | contraindication | 233917008 | DOID:0050820 |
| Labor pain | contraindication | 247412007 | |
| Raynaud's phenomenon | contraindication | 266261006 | |
| Syncope | contraindication | 271594007 | |
| Surgical procedure | contraindication | 387713003 | |
| Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
| Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
| Inflammatory dermatosis | contraindication | 703938007 | |
| Vagal Reflex Bradycardia | contraindication | ||
| Severe Cardiopulmonary Disease | contraindication |
๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.5 | Basic |
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 0.1MG/ML | ONYDA XR | TRIS PHARMA INC | N217645 | May 24, 2024 | RX | SUSPENSION, EXTENDED RELEASE | ORAL | 11918689 | July 28, 2041 | METHOD FOR DELIVERING AN EFFECTIVE AMOUNT OF CLONIDINE FOR A 24-HOUR PERIOD USING A SINGLE ORAL CLONIDINE COMPOSITION ACCORDING TO CLAIM 1 PRIOR TO BED TIME |
| 0.1MG/ML | ONYDA XR | TRIS PHARMA INC | N217645 | May 24, 2024 | RX | SUSPENSION, EXTENDED RELEASE | ORAL | 12576032 | July 28, 2041 | METHOD OF TREATING ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD) |
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor | GPCR | AGONIST | Ki | 8.42 | CHEMBL | CHEMBL | |||
| Alpha-2B adrenergic receptor | GPCR | AGONIST | Ki | 7.50 | CHEMBL | CHEMBL | |||
| Alpha-2C adrenergic receptor | GPCR | AGONIST | EC50 | 6.70 | WOMBAT-PK | CHEMBL | |||
| 5-hydroxytryptamine receptor 2C | GPCR | Ki | 5.16 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 7 | GPCR | Ki | 6.06 | CHEMBL | |||||
| Alpha-1A adrenergic receptor | GPCR | Ki | 6.50 | PDSP | |||||
| Alpha-1D adrenergic receptor | GPCR | Ki | 6.22 | CHEMBL | |||||
| Alpha-1B adrenergic receptor | GPCR | Ki | 6.50 | PDSP | |||||
| Solute carrier family 22 member 1 | Transporter | IC50 | 4.65 | CHEMBL | |||||
| Solute carrier family 22 member 2 | Transporter | IC50 | 4.80 | WOMBAT-PK | |||||
| Multidrug and toxin extrusion protein 1 | Transporter | IC50 | 4.48 | CHEMBL | |||||
| Transmembrane protein 97 | Enzyme | Ki | 5.56 | CHEMBL | |||||
| Nischarin | Membrane receptor | Ki | 8.05 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 1A | GPCR | Ki | 5.49 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 2A | GPCR | Ki | 5.04 | CHEMBL | |||||
| Alpha-1B adrenergic receptor | GPCR | Ki | 5.99 | DRUG MATRIX | |||||
| Alpha-1A adrenergic receptor | GPCR | Kd | 6.59 | CHEMBL | |||||
| Alpha-2B adrenergic receptor | GPCR | Ki | 8.08 | CHEMBL | |||||
| Alpha-1D adrenergic receptor | GPCR | AGONIST | Ki | 6.90 | IUPHAR | ||||
| 5-hydroxytryptamine receptor 1A | GPCR | IC50 | 5.27 | CHEMBL | |||||
| Alpha-2A adrenergic receptor | GPCR | Ki | 9.41 | CHEMBL | |||||
| Alpha-1A adrenergic receptor | GPCR | EC50 | 7.05 | CHEMBL | |||||
| Alpha-2A adrenergic receptor | GPCR | IC50 | 8.70 | CHEMBL | |||||
| Beta-1 adrenergic receptor | GPCR | Kd | 4.40 | CHEMBL | |||||
| Nischarin | Membrane receptor | Ki | 6.95 | CHEMBL | |||||
| Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Ion channel | BLOCKER | IC50 | 4.40 | IUPHAR | ||||
| Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Ion channel | BLOCKER | IC50 | 5.10 | IUPHAR | ||||
| Adrenergic receptor alpha-2 | GPCR | Ki | 8.82 | CHEMBL | |||||
| Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Ion channel | BLOCKER | IC50 | 5 | IUPHAR | ||||
| Alpha-1B adrenergic receptor | GPCR | EC50 | 7.08 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4017850 | VUID |
| N0000146207 | NUI |
| D00281 | KEGG_DRUG |
| 4205-91-8 | SECONDARY_CAS_RN |
| 142432 | RXNORM |
| C0009014 | UMLSCUI |
| CHEBI:46631 | CHEBI |
| CLU | PDB_CHEM_ID |
| CHEMBL134 | ChEMBL_ID |
| DB00575 | DRUGBANK_ID |
| CHEMBL1705 | ChEMBL_ID |
| D003000 | MESH_DESCRIPTOR_UI |
| 2803 | PUBCHEM_CID |
| 516 | IUPHAR_LIGAND_ID |
| 2624 | INN_ID |
| MN3L5RMN02 | UNII |
| 27687 | MMSL |
| 372108 | MMSL |
| 381 | MMSL |
| 4478 | MMSL |
| 4479 | MMSL |
| 89106 | MMSL |
| d00044 | MMSL |
| 000644 | NDDF |
| 004495 | NDDF |
| 372805007 | SNOMEDCT_US |
| 387121001 | SNOMEDCT_US |
| 62782004 | SNOMEDCT_US |
| 4017849 | VANDF |
| 4017850 | VANDF |
| MN3L5RMN02 | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9723 | INJECTION, SOLUTION | 500 ug | INTRAVENOUS | ANDA | 21 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9724 | INJECTION, SOLUTION | 100 ug | INTRAVENOUS | ANDA | 21 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2127 | TABLET | 0.10 mg | ORAL | ANDA | 11 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2128 | TABLET | 0.20 mg | ORAL | ANDA | 11 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2129 | TABLET | 0.30 mg | ORAL | ANDA | 11 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-4241 | TABLET, EXTENDED RELEASE | 0.10 mg | ORAL | ANDA | 19 sections |
| Clonidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0871 | PATCH | 0.10 mg | TRANSDERMAL | ANDA | 17 sections |
| Clonidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0872 | PATCH | 0.20 mg | TRANSDERMAL | ANDA | 17 sections |
| Clonidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0873 | PATCH | 0.30 mg | TRANSDERMAL | ANDA | 17 sections |
| Clonidine transdermal system | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3508 | PATCH | 0.10 mg | TRANSDERMAL | ANDA | 21 sections |
| Clonidine transdermal system | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3509 | PATCH | 0.20 mg | TRANSDERMAL | ANDA | 21 sections |
| Clonidine transdermal system | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3510 | PATCH | 0.30 mg | TRANSDERMAL | ANDA | 21 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-2572 | TABLET | 0.10 mg | ORAL | ANDA | 11 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-2574 | TABLET | 0.30 mg | ORAL | ANDA | 11 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8272 | TABLET | 0.20 mg | ORAL | ANDA | 11 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7442 | TABLET | 0.10 mg | ORAL | ANDA | 23 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7443 | TABLET | 0.20 mg | ORAL | ANDA | 23 sections |
| CLONIDINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10135-708 | TABLET | 0.10 mg | ORAL | ANDA | 20 sections |
| CLONIDINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10135-709 | TABLET | 0.20 mg | ORAL | ANDA | 20 sections |
| CLONIDINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10135-710 | TABLET | 0.30 mg | ORAL | ANDA | 20 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-042 | TABLET | 0.30 mg | ORAL | ANDA | 20 sections |
| CLONIDINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-158 | TABLET | 0.20 mg | ORAL | ANDA | 21 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-196 | TABLET | 0.10 mg | ORAL | ANDA | 24 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-199 | TABLET | 0.20 mg | ORAL | ANDA | 24 sections |
| Clonidine HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-465 | TABLET | 0.10 mg | ORAL | ANDA | 14 sections |
| CLONIDINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-266 | TABLET | 0.10 mg | ORAL | ANDA | 10 sections |
| CLONIDINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-267 | TABLET | 0.20 mg | ORAL | ANDA | 11 sections |
| CLONIDINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-371 | TABLET | 0.10 mg | ORAL | ANDA | 21 sections |
| CLONIDINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-372 | TABLET | 0.20 mg | ORAL | ANDA | 21 sections |
| CLONIDINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-377 | TABLET | 0.30 mg | ORAL | ANDA | 21 sections |