Stem definition | Drug id | CAS RN |
---|---|---|
916 | 58-73-1 |
Dose | Unit | Route |
---|---|---|
0.20 | g | O |
0.30 | g | O |
0.20 | g | R |
0.30 | g | R |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 1000 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 2 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 3.26 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 72 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 6.50 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 9.80 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.19 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 9.30 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
March 4, 1946 | FDA | MCNEIL CONS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 2930.30 | 10.51 | 5126 | 585047 | 128707 | 55573187 |
Toxicity to various agents | 2485.34 | 10.51 | 6515 | 583658 | 218049 | 55483845 |
Infusion related reaction | 1188.83 | 10.51 | 4834 | 585339 | 204097 | 55497797 |
Sinusitis | 527.02 | 10.51 | 3712 | 586461 | 193869 | 55508025 |
Overdose | 461.33 | 10.51 | 2264 | 587909 | 103566 | 55598328 |
Urticaria | 454.51 | 10.51 | 2832 | 587341 | 141844 | 55560050 |
Blood pressure fluctuation | 413.41 | 10.51 | 1140 | 589033 | 39220 | 55662674 |
Exposure to toxic agent | 410.67 | 10.51 | 327 | 589846 | 3351 | 55698543 |
Drug abuse | 395.14 | 10.51 | 1579 | 588594 | 66031 | 55635863 |
Pruritus | 389.63 | 10.51 | 5047 | 585126 | 311576 | 55390318 |
Acute hepatic failure | 369.55 | 10.51 | 641 | 589532 | 15937 | 55685957 |
Intentional product misuse | 365.20 | 10.51 | 1280 | 588893 | 50224 | 55651670 |
Muscle injury | 318.75 | 10.51 | 1241 | 588932 | 51259 | 55650635 |
Folliculitis | 313.23 | 10.51 | 1274 | 588899 | 53705 | 55648189 |
Flushing | 312.05 | 10.51 | 1509 | 588664 | 68591 | 55633303 |
Product dose omission issue | 278.48 | 10.51 | 1152 | 589021 | 203601 | 55498293 |
Irritable bowel syndrome | 271.85 | 10.51 | 1427 | 588746 | 67031 | 55634863 |
Respiratory arrest | 270.14 | 10.51 | 820 | 589353 | 29805 | 55672089 |
Lower respiratory tract infection | 255.09 | 10.51 | 2067 | 588106 | 112727 | 55589167 |
Psoriasis | 253.63 | 10.51 | 361 | 589812 | 92331 | 55609563 |
Intentional overdose | 250.23 | 10.51 | 1390 | 588783 | 66727 | 55635167 |
Injection site pain | 246.33 | 10.51 | 538 | 589635 | 116580 | 55585314 |
Cardio-respiratory arrest | 229.93 | 10.51 | 1168 | 589005 | 54153 | 55647741 |
Drug ineffective | 229.65 | 10.51 | 7624 | 582549 | 911365 | 54790529 |
Impaired healing | 226.70 | 10.51 | 1624 | 588549 | 85217 | 55616677 |
Device expulsion | 223.16 | 10.51 | 28 | 590145 | 30421 | 55671473 |
Ill-defined disorder | 208.93 | 10.51 | 1332 | 588841 | 67211 | 55634683 |
Diarrhoea | 207.52 | 10.51 | 5106 | 585067 | 633401 | 55068493 |
Throat irritation | 206.90 | 10.51 | 783 | 589390 | 31900 | 55669994 |
Hypersensitivity | 204.54 | 10.51 | 3800 | 586373 | 252608 | 55449286 |
Sleep disorder due to general medical condition, insomnia type | 203.05 | 10.51 | 947 | 589226 | 42391 | 55659503 |
Blister | 200.90 | 10.51 | 1882 | 588291 | 107005 | 55594889 |
Anaemia | 197.99 | 10.51 | 1821 | 588352 | 265690 | 55436204 |
Cardiac failure | 187.98 | 10.51 | 359 | 589814 | 81734 | 55620160 |
Nasopharyngitis | 185.76 | 10.51 | 3302 | 586871 | 217657 | 55484237 |
Metabolic acidosis | 183.69 | 10.51 | 876 | 589297 | 39578 | 55662316 |
Anion gap | 178.15 | 10.51 | 124 | 590049 | 1015 | 55700879 |
Intentional product use issue | 174.17 | 10.51 | 1704 | 588469 | 98029 | 55603865 |
Body temperature increased | 172.15 | 10.51 | 764 | 589409 | 33478 | 55668416 |
Acute kidney injury | 167.86 | 10.51 | 1663 | 588510 | 239100 | 55462794 |
Drug interaction | 165.63 | 10.51 | 1404 | 588769 | 208351 | 55493543 |
Exposure via ingestion | 164.61 | 10.51 | 174 | 589999 | 2634 | 55699260 |
Oxygen saturation decreased | 164.50 | 10.51 | 1403 | 588770 | 77664 | 55624230 |
Blood pressure increased | 160.30 | 10.51 | 2271 | 587902 | 142905 | 55558989 |
Blood pressure diastolic abnormal | 160.06 | 10.51 | 367 | 589806 | 11231 | 55690663 |
Cardiac failure congestive | 159.95 | 10.51 | 434 | 589739 | 87286 | 55614608 |
Helicobacter infection | 158.21 | 10.51 | 1311 | 588862 | 71957 | 55629937 |
Duodenal ulcer perforation | 155.76 | 10.51 | 1238 | 588935 | 67104 | 55634790 |
Blood pressure systolic increased | 153.07 | 10.51 | 838 | 589335 | 39998 | 55661896 |
Neutropenia | 149.33 | 10.51 | 1007 | 589166 | 157160 | 55544734 |
Heart rate increased | 147.45 | 10.51 | 1427 | 588746 | 81846 | 55620048 |
Wrong technique in product usage process | 143.36 | 10.51 | 243 | 589930 | 57925 | 55643969 |
Infusion site pain | 138.18 | 10.51 | 386 | 589787 | 13376 | 55688518 |
Poisoning | 134.22 | 10.51 | 365 | 589808 | 12448 | 55689446 |
Urine abnormality | 132.62 | 10.51 | 246 | 589927 | 6453 | 55695441 |
Malignant neoplasm progression | 131.22 | 10.51 | 368 | 589805 | 73219 | 55628675 |
Blood pressure systolic abnormal | 131.21 | 10.51 | 306 | 589867 | 9471 | 55692423 |
Hepatotoxicity | 130.99 | 10.51 | 660 | 589513 | 30493 | 55671401 |
Sopor | 129.70 | 10.51 | 30 | 590143 | 20892 | 55681002 |
Heart rate decreased | 127.12 | 10.51 | 792 | 589381 | 39635 | 55662259 |
Osteonecrosis of jaw | 127.11 | 10.51 | 98 | 590075 | 33260 | 55668634 |
Infusion site swelling | 125.57 | 10.51 | 265 | 589908 | 7656 | 55694238 |
Renal impairment | 123.90 | 10.51 | 432 | 589741 | 80281 | 55621613 |
Medication error | 122.43 | 10.51 | 812 | 589361 | 41523 | 55660371 |
Drug resistance | 120.49 | 10.51 | 33 | 590140 | 20509 | 55681385 |
Stomatitis | 120.06 | 10.51 | 1856 | 588317 | 118954 | 55582940 |
Pericarditis | 118.22 | 10.51 | 1699 | 588474 | 107224 | 55594670 |
Gastrointestinal disorder | 117.62 | 10.51 | 1746 | 588427 | 110956 | 55590938 |
Anti-cyclic citrullinated peptide antibody positive | 117.16 | 10.51 | 1563 | 588610 | 97037 | 55604857 |
Hereditary angioedema | 115.78 | 10.51 | 235 | 589938 | 6600 | 55695294 |
Synovitis | 115.35 | 10.51 | 2352 | 587821 | 158953 | 55542941 |
Weight increased | 113.30 | 10.51 | 3182 | 586991 | 226521 | 55475373 |
Injection site bruising | 111.42 | 10.51 | 144 | 590029 | 38377 | 55663517 |
Throat tightness | 110.41 | 10.51 | 497 | 589676 | 21910 | 55679984 |
Infusion site erythema | 109.10 | 10.51 | 282 | 589891 | 9324 | 55692570 |
Injection site erythema | 106.86 | 10.51 | 433 | 589740 | 77015 | 55624879 |
Therapy cessation | 106.58 | 10.51 | 78 | 590095 | 27186 | 55674708 |
Urine leukocyte esterase positive | 106.33 | 10.51 | 147 | 590026 | 2981 | 55698913 |
Hepatic cytolysis | 105.69 | 10.51 | 302 | 589871 | 10604 | 55691290 |
Analgesic drug level increased | 105.20 | 10.51 | 112 | 590061 | 1710 | 55700184 |
Pancytopenia | 103.29 | 10.51 | 528 | 589645 | 88187 | 55613707 |
Hospitalisation | 103.04 | 10.51 | 420 | 589753 | 74580 | 55627314 |
Hepatic enzyme increased | 102.85 | 10.51 | 2437 | 587736 | 168947 | 55532947 |
Peripheral swelling | 100.18 | 10.51 | 3194 | 586979 | 231532 | 55470362 |
Hyperkalaemia | 98.57 | 10.51 | 244 | 589929 | 50621 | 55651273 |
Therapeutic product effect incomplete | 98.57 | 10.51 | 678 | 589495 | 105353 | 55596541 |
Infusion site extravasation | 95.29 | 10.51 | 243 | 589930 | 7967 | 55693927 |
Blood pressure diastolic decreased | 94.01 | 10.51 | 427 | 589746 | 18896 | 55682998 |
Myocardial infarction | 92.81 | 10.51 | 581 | 589592 | 92289 | 55609605 |
Rash | 92.39 | 10.51 | 6172 | 584001 | 486875 | 55215019 |
Joint swelling | 91.36 | 10.51 | 3811 | 586362 | 285989 | 55415905 |
Interstitial lung disease | 90.57 | 10.51 | 301 | 589872 | 56762 | 55645132 |
Sedation complication | 89.63 | 10.51 | 298 | 589875 | 11374 | 55690520 |
Infusion site pruritus | 89.55 | 10.51 | 172 | 590001 | 4635 | 55697259 |
Abortion spontaneous | 87.85 | 10.51 | 206 | 589967 | 43547 | 55658347 |
Pulmonary arterial hypertension | 86.43 | 10.51 | 90 | 590083 | 26413 | 55675481 |
Plasma cell myeloma | 86.35 | 10.51 | 229 | 589944 | 46417 | 55655477 |
Therapeutic product effect decreased | 85.91 | 10.51 | 2356 | 587817 | 167096 | 55534798 |
Thrombocytopenia | 85.85 | 10.51 | 963 | 589210 | 135261 | 55566633 |
Hyponatraemia | 85.40 | 10.51 | 673 | 589500 | 101466 | 55600428 |
Food allergy | 85.17 | 10.51 | 244 | 589929 | 8580 | 55693314 |
Lymphocyte count decreased | 80.84 | 10.51 | 536 | 589637 | 27403 | 55674491 |
Suspected suicide | 79.93 | 10.51 | 177 | 589996 | 5289 | 55696605 |
Chest discomfort | 79.28 | 10.51 | 1467 | 588706 | 97390 | 55604504 |
Discomfort | 78.48 | 10.51 | 1994 | 588179 | 139767 | 55562127 |
Cerebrovascular accident | 78.46 | 10.51 | 664 | 589509 | 98606 | 55603288 |
Ear pain | 78.43 | 10.51 | 574 | 589599 | 30316 | 55671578 |
Depressed level of consciousness | 78.33 | 10.51 | 921 | 589252 | 55512 | 55646382 |
Poor venous access | 78.01 | 10.51 | 295 | 589878 | 12011 | 55689883 |
Disease progression | 77.18 | 10.51 | 717 | 589456 | 104456 | 55597438 |
Renal failure | 76.99 | 10.51 | 763 | 589410 | 109737 | 55592157 |
White blood cells urine positive | 76.52 | 10.51 | 161 | 590012 | 4641 | 55697253 |
Epilepsy | 76.45 | 10.51 | 91 | 590082 | 25140 | 55676754 |
Product substitution issue | 75.83 | 10.51 | 29 | 590144 | 14570 | 55687324 |
Crystal urine present | 74.95 | 10.51 | 88 | 590085 | 1505 | 55700389 |
Pneumonia | 73.38 | 10.51 | 3504 | 586669 | 403594 | 55298300 |
Posterior reversible encephalopathy syndrome | 71.54 | 10.51 | 39 | 590134 | 15921 | 55685973 |
Ear infection | 71.32 | 10.51 | 567 | 589606 | 30728 | 55671166 |
Neoplasm progression | 70.68 | 10.51 | 143 | 590030 | 31873 | 55670021 |
Ear pruritus | 70.25 | 10.51 | 117 | 590056 | 2811 | 55699083 |
Deafness transitory | 70.16 | 10.51 | 94 | 590079 | 1848 | 55700046 |
Diabetes mellitus | 70.14 | 10.51 | 299 | 589874 | 52436 | 55649458 |
Pharyngitis | 69.84 | 10.51 | 381 | 589792 | 18157 | 55683737 |
Urinary sediment present | 69.44 | 10.51 | 97 | 590076 | 1987 | 55699907 |
Anticholinergic syndrome | 68.93 | 10.51 | 93 | 590080 | 1841 | 55700053 |
Coagulopathy | 68.73 | 10.51 | 382 | 589791 | 18334 | 55683560 |
Foetal exposure during pregnancy | 68.10 | 10.51 | 159 | 590014 | 33664 | 55668230 |
Suicide attempt | 67.92 | 10.51 | 915 | 589258 | 56921 | 55644973 |
Erythema | 67.53 | 10.51 | 2126 | 588047 | 153813 | 55548081 |
Creatinine renal clearance decreased | 67.33 | 10.51 | 317 | 589856 | 14242 | 55687652 |
Oedema peripheral | 67.14 | 10.51 | 1328 | 588845 | 169926 | 55531968 |
Neuropathy peripheral | 66.95 | 10.51 | 722 | 589451 | 102171 | 55599723 |
Product prescribing error | 64.68 | 10.51 | 89 | 590084 | 23097 | 55678797 |
Temperature regulation disorder | 64.57 | 10.51 | 144 | 590029 | 4324 | 55697570 |
Acute lung injury | 64.24 | 10.51 | 78 | 590095 | 1384 | 55700510 |
Swelling | 64.09 | 10.51 | 3101 | 587072 | 236670 | 55465224 |
Chills | 63.65 | 10.51 | 1466 | 588707 | 101138 | 55600756 |
Product storage error | 62.64 | 10.51 | 30 | 590143 | 13183 | 55688711 |
Pulmonary hypertension | 62.41 | 10.51 | 182 | 589991 | 35762 | 55666132 |
Injury | 61.92 | 10.51 | 926 | 589247 | 58925 | 55642969 |
Bone marrow failure | 61.88 | 10.51 | 127 | 590046 | 28159 | 55673735 |
Cardiac arrest | 61.12 | 10.51 | 1257 | 588916 | 85057 | 55616837 |
Fall | 60.33 | 10.51 | 3098 | 587075 | 354412 | 55347482 |
Hepatic necrosis | 59.28 | 10.51 | 155 | 590018 | 5161 | 55696733 |
Respiratory failure | 59.09 | 10.51 | 674 | 589499 | 94388 | 55607506 |
Red blood cells urine positive | 59.08 | 10.51 | 109 | 590064 | 2847 | 55699047 |
No adverse event | 58.32 | 10.51 | 191 | 589982 | 36183 | 55665711 |
Lactic acidosis | 57.78 | 10.51 | 184 | 589989 | 35162 | 55666732 |
Atrial fibrillation | 57.62 | 10.51 | 799 | 589374 | 108098 | 55593796 |
Tachycardia | 57.33 | 10.51 | 1485 | 588688 | 104391 | 55597503 |
Feeling hot | 56.67 | 10.51 | 679 | 589494 | 41108 | 55660786 |
Leukopenia | 56.27 | 10.51 | 474 | 589699 | 70466 | 55631428 |
Anaphylactic reaction | 56.15 | 10.51 | 900 | 589273 | 58095 | 55643799 |
Blood calcium decreased | 56.01 | 10.51 | 434 | 589739 | 23335 | 55678559 |
Device malfunction | 55.84 | 10.51 | 52 | 590121 | 16084 | 55685810 |
Respiratory rate increased | 55.54 | 10.51 | 265 | 589908 | 11972 | 55689922 |
Myelodysplastic syndrome | 55.45 | 10.51 | 54 | 590119 | 16352 | 55685542 |
Heart rate irregular | 55.24 | 10.51 | 389 | 589784 | 20290 | 55681604 |
Pyrexia | 55.05 | 10.51 | 5101 | 585072 | 413672 | 55288222 |
Muscle spasticity | 54.21 | 10.51 | 377 | 589796 | 19583 | 55682311 |
Septic shock | 54.07 | 10.51 | 394 | 589779 | 60441 | 55641453 |
Infection | 54.04 | 10.51 | 2592 | 587581 | 197614 | 55504280 |
Cytomegalovirus infection | 53.89 | 10.51 | 74 | 590099 | 19222 | 55682672 |
Breast cancer stage I | 53.08 | 10.51 | 3 | 590170 | 6227 | 55695667 |
Sepsis | 52.82 | 10.51 | 1091 | 589082 | 138749 | 55563145 |
Product quality issue | 52.73 | 10.51 | 164 | 590009 | 31572 | 55670322 |
Syncope | 52.67 | 10.51 | 807 | 589366 | 107392 | 55594502 |
Cholecystitis chronic | 52.43 | 10.51 | 222 | 589951 | 9526 | 55692368 |
Osteoarthritis | 52.40 | 10.51 | 563 | 589610 | 79733 | 55622161 |
Infusion site bruising | 51.70 | 10.51 | 100 | 590073 | 2709 | 55699185 |
Cognitive disorder | 50.36 | 10.51 | 759 | 589414 | 48374 | 55653520 |
Diabetic ketoacidosis | 50.11 | 10.51 | 75 | 590098 | 18796 | 55683098 |
Breast cancer female | 49.93 | 10.51 | 34 | 590139 | 12304 | 55689590 |
Pneumocystis jirovecii pneumonia | 49.33 | 10.51 | 55 | 590118 | 15646 | 55686248 |
Blood pressure diastolic increased | 49.21 | 10.51 | 199 | 589974 | 8362 | 55693532 |
Device dislocation | 49.02 | 10.51 | 102 | 590071 | 22504 | 55679390 |
Gastrointestinal haemorrhage | 48.98 | 10.51 | 534 | 589639 | 75417 | 55626477 |
Hypokalaemia | 48.16 | 10.51 | 698 | 589475 | 93739 | 55608155 |
Red cell distribution width increased | 48.15 | 10.51 | 210 | 589963 | 9130 | 55692764 |
Blood urine present | 47.36 | 10.51 | 273 | 589900 | 13282 | 55688612 |
Headache | 47.27 | 10.51 | 6617 | 583556 | 552427 | 55149467 |
Psoriatic arthropathy | 47.06 | 10.51 | 522 | 589651 | 73486 | 55628408 |
Lymphocyte percentage decreased | 47.01 | 10.51 | 97 | 590076 | 2757 | 55699137 |
Dyspnoea exertional | 46.32 | 10.51 | 359 | 589814 | 54330 | 55647564 |
Pyroglutamate increased | 46.16 | 10.51 | 37 | 590136 | 383 | 55701511 |
Full blood count abnormal | 45.93 | 10.51 | 134 | 590039 | 26328 | 55675566 |
Injection site reaction | 45.82 | 10.51 | 348 | 589825 | 52899 | 55648995 |
Hepatic failure | 45.79 | 10.51 | 545 | 589628 | 32941 | 55668953 |
Therapy interrupted | 45.77 | 10.51 | 128 | 590045 | 25497 | 55676397 |
Premature delivery | 45.55 | 10.51 | 139 | 590034 | 26921 | 55674973 |
Haematotoxicity | 44.64 | 10.51 | 16 | 590157 | 8367 | 55693527 |
Visual acuity reduced | 44.54 | 10.51 | 94 | 590079 | 20632 | 55681262 |
Pyroglutamic acidosis | 44.13 | 10.51 | 38 | 590135 | 438 | 55701456 |
Hypocalcaemia | 44.07 | 10.51 | 154 | 590019 | 28606 | 55673288 |
Arthralgia | 43.24 | 10.51 | 5945 | 584228 | 495724 | 55206170 |
Respiratory depression | 43.15 | 10.51 | 250 | 589923 | 12185 | 55689709 |
Urine ketone body present | 42.99 | 10.51 | 84 | 590089 | 2293 | 55699601 |
Body temperature decreased | 42.87 | 10.51 | 331 | 589842 | 17777 | 55684117 |
Mucosal inflammation | 42.66 | 10.51 | 268 | 589905 | 42542 | 55659352 |
Postmortem blood drug level increased | 42.61 | 10.51 | 41 | 590132 | 551 | 55701343 |
Accidental overdose | 42.48 | 10.51 | 363 | 589810 | 20098 | 55681796 |
Administration site swelling | 42.26 | 10.51 | 55 | 590118 | 1050 | 55700844 |
Gastrooesophageal reflux disease | 42.23 | 10.51 | 616 | 589557 | 82641 | 55619253 |
Neutrophil percentage increased | 42.10 | 10.51 | 92 | 590081 | 2724 | 55699170 |
Surgery | 42.09 | 10.51 | 186 | 589987 | 32300 | 55669594 |
Hand deformity | 41.45 | 10.51 | 1765 | 588408 | 132727 | 55569167 |
Osteonecrosis | 41.44 | 10.51 | 116 | 590057 | 23099 | 55678795 |
Bone erosion | 41.25 | 10.51 | 58 | 590115 | 14916 | 55686978 |
Hypertensive crisis | 41.07 | 10.51 | 52 | 590121 | 13984 | 55687910 |
Infusion site nodule | 40.95 | 10.51 | 58 | 590115 | 1204 | 55700690 |
Pathogen resistance | 40.54 | 10.51 | 7 | 590166 | 5993 | 55695901 |
Injection site haemorrhage | 40.32 | 10.51 | 110 | 590063 | 22091 | 55679803 |
Multiple organ dysfunction syndrome | 39.89 | 10.51 | 357 | 589816 | 52413 | 55649481 |
Right ventricular failure | 39.82 | 10.51 | 69 | 590104 | 16310 | 55685584 |
Second primary malignancy | 39.63 | 10.51 | 14 | 590159 | 7388 | 55694506 |
Injection site pruritus | 39.50 | 10.51 | 267 | 589906 | 41664 | 55660230 |
Cerebral haemorrhage | 39.40 | 10.51 | 160 | 590013 | 28446 | 55673448 |
Transient ischaemic attack | 38.97 | 10.51 | 200 | 589973 | 33377 | 55668517 |
Night sweats | 38.94 | 10.51 | 628 | 589545 | 40585 | 55661309 |
Product use in unapproved indication | 38.67 | 10.51 | 1152 | 589021 | 139670 | 55562224 |
Dehydration | 38.64 | 10.51 | 1320 | 588853 | 157505 | 55544389 |
Decreased appetite | 38.60 | 10.51 | 1891 | 588282 | 217340 | 55484554 |
Accidental death | 38.45 | 10.51 | 69 | 590104 | 1763 | 55700131 |
Pain | 38.23 | 10.51 | 7690 | 582483 | 655494 | 55046400 |
Intentional self-injury | 38.18 | 10.51 | 134 | 590039 | 24858 | 55677036 |
Suicidal ideation | 38.02 | 10.51 | 404 | 589769 | 57338 | 55644556 |
Breast cancer | 37.96 | 10.51 | 328 | 589845 | 48505 | 55653389 |
Body temperature fluctuation | 37.93 | 10.51 | 74 | 590099 | 2018 | 55699876 |
Memory impairment | 37.69 | 10.51 | 659 | 589514 | 85898 | 55615996 |
Gait disturbance | 37.52 | 10.51 | 1367 | 588806 | 161954 | 55539940 |
Coronary artery disease | 37.13 | 10.51 | 181 | 589992 | 30615 | 55671279 |
Incorrect drug administration rate | 36.97 | 10.51 | 94 | 590079 | 3076 | 55698818 |
Anion gap abnormal | 36.78 | 10.51 | 30 | 590143 | 319 | 55701575 |
Arthropathy | 36.60 | 10.51 | 2503 | 587670 | 197772 | 55504122 |
Electric shock | 36.53 | 10.51 | 51 | 590122 | 1044 | 55700850 |
Inappropriate antidiuretic hormone secretion | 36.21 | 10.51 | 55 | 590118 | 13701 | 55688193 |
Metastases to bone | 35.93 | 10.51 | 96 | 590077 | 19412 | 55682482 |
Maternal exposure during pregnancy | 35.55 | 10.51 | 1624 | 588549 | 187929 | 55513965 |
Injection site swelling | 35.54 | 10.51 | 289 | 589884 | 43289 | 55658605 |
Polyneuropathy | 35.50 | 10.51 | 51 | 590122 | 12999 | 55688895 |
Alopecia | 35.40 | 10.51 | 2623 | 587550 | 290835 | 55411059 |
Infusion site mass | 34.97 | 10.51 | 59 | 590114 | 1433 | 55700461 |
Pneumonia viral | 34.68 | 10.51 | 158 | 590015 | 7000 | 55694894 |
Hepatic cirrhosis | 34.53 | 10.51 | 111 | 590062 | 21152 | 55680742 |
Sedation | 34.40 | 10.51 | 535 | 589638 | 34319 | 55667575 |
Gestational diabetes | 34.30 | 10.51 | 21 | 590152 | 8043 | 55693851 |
Immunodeficiency | 34.26 | 10.51 | 288 | 589885 | 15869 | 55686025 |
Chronic kidney disease | 34.26 | 10.51 | 279 | 589894 | 41777 | 55660117 |
Febrile bone marrow aplasia | 34.22 | 10.51 | 13 | 590160 | 6559 | 55695335 |
Palmar-plantar erythrodysaesthesia syndrome | 34.19 | 10.51 | 110 | 590063 | 20955 | 55680939 |
Lung neoplasm malignant | 34.05 | 10.51 | 83 | 590090 | 17313 | 55684581 |
Depression | 33.81 | 10.51 | 1543 | 588630 | 178574 | 55523320 |
Disease recurrence | 33.78 | 10.51 | 132 | 590041 | 23728 | 55678166 |
Myelosuppression | 33.60 | 10.51 | 84 | 590089 | 17371 | 55684523 |
Device difficult to use | 33.47 | 10.51 | 38 | 590135 | 10723 | 55691171 |
Accidental exposure to product | 33.23 | 10.51 | 139 | 590034 | 24508 | 55677386 |
Transplant rejection | 33.23 | 10.51 | 33 | 590140 | 9901 | 55691993 |
Acute myeloid leukaemia | 33.20 | 10.51 | 81 | 590092 | 16891 | 55685003 |
Treatment noncompliance | 33.14 | 10.51 | 203 | 589970 | 32420 | 55669474 |
Fracture | 32.93 | 10.51 | 89 | 590084 | 17929 | 55683965 |
Injection site warmth | 32.83 | 10.51 | 62 | 590111 | 14181 | 55687713 |
Administration site pain | 32.76 | 10.51 | 40 | 590133 | 714 | 55701180 |
Exposure during pregnancy | 32.72 | 10.51 | 1135 | 589038 | 135207 | 55566687 |
Infusion site haemorrhage | 32.63 | 10.51 | 99 | 590074 | 3596 | 55698298 |
Cardiac failure acute | 32.63 | 10.51 | 27 | 590146 | 8846 | 55693048 |
Post transplant lymphoproliferative disorder | 32.57 | 10.51 | 5 | 590168 | 4667 | 55697227 |
Ischaemic stroke | 32.46 | 10.51 | 81 | 590092 | 16761 | 55685133 |
Renal disorder | 32.32 | 10.51 | 180 | 589993 | 29425 | 55672469 |
Agranulocytosis | 32.31 | 10.51 | 125 | 590048 | 22534 | 55679360 |
Pharyngeal paraesthesia | 32.21 | 10.51 | 61 | 590112 | 1626 | 55700268 |
Therapeutic response shortened | 32.12 | 10.51 | 188 | 589985 | 9198 | 55692696 |
Wound | 32.10 | 10.51 | 1771 | 588402 | 137033 | 55564861 |
Unintentional medical device removal | 31.83 | 10.51 | 10 | 590163 | 5684 | 55696210 |
Labelled drug-drug interaction medication error | 31.79 | 10.51 | 45 | 590128 | 11541 | 55690353 |
Breast cancer metastatic | 31.72 | 10.51 | 72 | 590101 | 15397 | 55686497 |
Culture urine positive | 31.60 | 10.51 | 95 | 590078 | 3433 | 55698461 |
Platelet count decreased | 31.55 | 10.51 | 861 | 589312 | 105522 | 55596372 |
Specific gravity urine decreased | 31.53 | 10.51 | 39 | 590134 | 706 | 55701188 |
Rheumatic fever | 31.38 | 10.51 | 450 | 589723 | 28377 | 55673517 |
Contusion | 31.37 | 10.51 | 1647 | 588526 | 126783 | 55575111 |
Full blood count decreased | 31.28 | 10.51 | 132 | 590041 | 23217 | 55678677 |
Hyperglycaemia | 31.16 | 10.51 | 254 | 589919 | 38027 | 55663867 |
White blood cell count decreased | 31.12 | 10.51 | 1045 | 589128 | 124945 | 55576949 |
Rash erythematous | 31.10 | 10.51 | 556 | 589617 | 36665 | 55665229 |
Metastases to liver | 30.83 | 10.51 | 119 | 590054 | 21467 | 55680427 |
Thrombotic microangiopathy | 30.64 | 10.51 | 32 | 590141 | 9379 | 55692515 |
Infusion site discomfort | 30.50 | 10.51 | 47 | 590126 | 1055 | 55700839 |
Bursitis | 30.20 | 10.51 | 431 | 589742 | 27151 | 55674743 |
Chronic obstructive pulmonary disease | 30.10 | 10.51 | 422 | 589751 | 56993 | 55644901 |
Blood glucose increased | 29.65 | 10.51 | 582 | 589591 | 74569 | 55627325 |
Heart rate abnormal | 29.42 | 10.51 | 109 | 590064 | 4394 | 55697500 |
Cerebral infarction | 29.07 | 10.51 | 129 | 590044 | 22376 | 55679518 |
Breast cancer stage II | 28.98 | 10.51 | 12 | 590161 | 5746 | 55696148 |
Haemoglobin urine present | 28.91 | 10.51 | 39 | 590134 | 772 | 55701122 |
Complication associated with device | 28.68 | 10.51 | 75 | 590098 | 15275 | 55686619 |
Infusion site rash | 28.48 | 10.51 | 56 | 590117 | 1536 | 55700358 |
Injection site mass | 28.45 | 10.51 | 86 | 590087 | 16707 | 55685187 |
Haemorrhage | 28.34 | 10.51 | 418 | 589755 | 55979 | 55645915 |
Mydriasis | 28.26 | 10.51 | 206 | 589967 | 10865 | 55691029 |
Hepatocellular injury | 27.98 | 10.51 | 163 | 590010 | 26351 | 55675543 |
Seizure | 27.67 | 10.51 | 1052 | 589121 | 124067 | 55577827 |
Therapeutic response decreased | 27.57 | 10.51 | 388 | 589785 | 52370 | 55649524 |
Asthma | 27.47 | 10.51 | 937 | 589236 | 111833 | 55590061 |
Soft tissue disorder | 27.43 | 10.51 | 103 | 590070 | 4179 | 55697715 |
Neurotoxicity | 27.40 | 10.51 | 80 | 590093 | 15715 | 55686179 |
Urine analysis abnormal | 27.40 | 10.51 | 110 | 590063 | 4607 | 55697287 |
Infusion site urticaria | 27.39 | 10.51 | 48 | 590125 | 1203 | 55700691 |
Brain death | 27.36 | 10.51 | 81 | 590092 | 2902 | 55698992 |
Spinal stenosis | 27.32 | 10.51 | 67 | 590106 | 13947 | 55687947 |
Injection site rash | 27.21 | 10.51 | 89 | 590084 | 16869 | 55685025 |
Confusional state | 27.18 | 10.51 | 2535 | 587638 | 205620 | 55496274 |
Transplant dysfunction | 27.14 | 10.51 | 8 | 590165 | 4738 | 55697156 |
Epistaxis | 27.06 | 10.51 | 517 | 589656 | 66506 | 55635388 |
Alanine aminotransferase increased | 26.82 | 10.51 | 1220 | 588953 | 92442 | 55609452 |
Orthostatic hypotension | 26.71 | 10.51 | 493 | 589680 | 32706 | 55669188 |
Ascites | 26.65 | 10.51 | 258 | 589915 | 37286 | 55664608 |
Incorrect dose administered by device | 26.65 | 10.51 | 4 | 590169 | 3796 | 55698098 |
Mobility decreased | 26.54 | 10.51 | 1281 | 588892 | 97710 | 55604184 |
Swollen joint count increased | 26.51 | 10.51 | 378 | 589795 | 23806 | 55678088 |
C-reactive protein abnormal | 26.35 | 10.51 | 537 | 589636 | 36272 | 55665622 |
Diffuse large B-cell lymphoma | 26.24 | 10.51 | 21 | 590152 | 6995 | 55694899 |
Multiple-drug resistance | 26.06 | 10.51 | 5 | 590168 | 3969 | 55697925 |
Abortion induced | 25.93 | 10.51 | 38 | 590135 | 9607 | 55692287 |
Hypotension | 25.92 | 10.51 | 3003 | 587170 | 247505 | 55454389 |
Unevaluable event | 25.89 | 10.51 | 348 | 589825 | 47339 | 55654555 |
Respiratory disorder | 25.85 | 10.51 | 500 | 589673 | 33457 | 55668437 |
Bacterial test positive | 25.84 | 10.51 | 112 | 590061 | 4856 | 55697038 |
Gastrointestinal pain | 25.76 | 10.51 | 169 | 590004 | 8608 | 55693286 |
Bacterial test | 25.67 | 10.51 | 45 | 590128 | 1128 | 55700766 |
Colorectal cancer | 25.50 | 10.51 | 3 | 590170 | 3426 | 55698468 |
Toxicologic test abnormal | 25.32 | 10.51 | 34 | 590139 | 670 | 55701224 |
Unresponsive to stimuli | 25.14 | 10.51 | 470 | 589703 | 31255 | 55670639 |
Sexual dysfunction | 25.11 | 10.51 | 3 | 590170 | 3385 | 55698509 |
Acute myocardial infarction | 25.04 | 10.51 | 201 | 589972 | 30192 | 55671702 |
Device use error | 24.94 | 10.51 | 13 | 590160 | 5443 | 55696451 |
Device issue | 24.90 | 10.51 | 125 | 590048 | 20981 | 55680913 |
Bronchopulmonary aspergillosis | 24.83 | 10.51 | 30 | 590143 | 8234 | 55693660 |
Electrolyte imbalance | 24.75 | 10.51 | 101 | 590072 | 17932 | 55683962 |
Atypical femur fracture | 24.64 | 10.51 | 11 | 590162 | 5036 | 55696858 |
Serum sickness | 24.48 | 10.51 | 72 | 590101 | 2570 | 55699324 |
Hypothyroidism | 24.44 | 10.51 | 269 | 589904 | 37927 | 55663967 |
Meningitis aseptic | 24.29 | 10.51 | 101 | 590072 | 4298 | 55697596 |
Substance abuse | 24.29 | 10.51 | 103 | 590070 | 4422 | 55697472 |
Anticipatory anxiety | 24.15 | 10.51 | 41 | 590132 | 1001 | 55700893 |
Blood pH decreased | 24.10 | 10.51 | 69 | 590104 | 2425 | 55699469 |
Inappropriate schedule of product administration | 24.05 | 10.51 | 1087 | 589086 | 82300 | 55619594 |
Hypoglycaemia | 23.95 | 10.51 | 426 | 589747 | 55389 | 55646505 |
Hip fracture | 23.81 | 10.51 | 175 | 589998 | 26798 | 55675096 |
Haemophagocytic lymphohistiocytosis | 23.56 | 10.51 | 40 | 590133 | 9532 | 55692362 |
Anion gap increased | 23.56 | 10.51 | 51 | 590122 | 1500 | 55700394 |
Oral pruritus | 23.50 | 10.51 | 56 | 590117 | 1758 | 55700136 |
Metastases to lymph nodes | 23.32 | 10.51 | 26 | 590147 | 7397 | 55694497 |
Hyperlipidaemia | 23.27 | 10.51 | 104 | 590069 | 18005 | 55683889 |
Rheumatoid factor positive | 23.25 | 10.51 | 915 | 589258 | 68145 | 55633749 |
Pancreatic carcinoma | 23.15 | 10.51 | 25 | 590148 | 7216 | 55694678 |
Opiates positive | 23.03 | 10.51 | 24 | 590149 | 357 | 55701537 |
Iron deficiency anaemia | 22.97 | 10.51 | 103 | 590070 | 17816 | 55684078 |
Endophthalmitis | 22.76 | 10.51 | 3 | 590170 | 3140 | 55698754 |
Cytokine release syndrome | 22.61 | 10.51 | 193 | 589980 | 10682 | 55691212 |
Drug use disorder | 22.58 | 10.51 | 103 | 590070 | 4566 | 55697328 |
Emotional distress | 22.57 | 10.51 | 438 | 589735 | 29325 | 55672569 |
Macular oedema | 22.43 | 10.51 | 6 | 590167 | 3788 | 55698106 |
Analgesic drug level above therapeutic | 22.34 | 10.51 | 17 | 590156 | 162 | 55701732 |
Acute graft versus host disease | 22.18 | 10.51 | 8 | 590165 | 4167 | 55697727 |
Graft versus host disease | 22.14 | 10.51 | 23 | 590150 | 6758 | 55695136 |
Joint stiffness | 22.06 | 10.51 | 251 | 589922 | 35174 | 55666720 |
Altered state of consciousness | 21.97 | 10.51 | 146 | 590027 | 22875 | 55679019 |
Poisoning deliberate | 21.95 | 10.51 | 179 | 589994 | 9774 | 55692120 |
Vitamin K deficiency | 21.86 | 10.51 | 25 | 590148 | 415 | 55701479 |
Systemic infection | 21.68 | 10.51 | 4 | 590169 | 3265 | 55698629 |
Ageusia | 21.64 | 10.51 | 63 | 590110 | 12388 | 55689506 |
Myalgia | 21.64 | 10.51 | 1147 | 589026 | 130878 | 55571016 |
Pleural effusion | 21.57 | 10.51 | 707 | 589466 | 84773 | 55617121 |
Chronic graft versus host disease | 21.56 | 10.51 | 4 | 590169 | 3252 | 55698642 |
Haematocrit decreased | 21.53 | 10.51 | 522 | 589651 | 36307 | 55665587 |
Vaginal haemorrhage | 21.51 | 10.51 | 169 | 590004 | 25504 | 55676390 |
Muscle spasms | 21.48 | 10.51 | 1199 | 588974 | 136172 | 55565722 |
Metastases to lung | 21.33 | 10.51 | 58 | 590115 | 11660 | 55690234 |
Mast cell activation syndrome | 21.28 | 10.51 | 31 | 590142 | 661 | 55701233 |
Immune reconstitution inflammatory syndrome | 21.20 | 10.51 | 17 | 590156 | 5657 | 55696237 |
Upper respiratory tract infection | 21.15 | 10.51 | 932 | 589241 | 70356 | 55631538 |
Drug screen positive | 21.10 | 10.51 | 82 | 590091 | 3382 | 55698512 |
Electrocardiogram QRS complex prolonged | 21.02 | 10.51 | 113 | 590060 | 5354 | 55696540 |
Subdural haematoma | 20.87 | 10.51 | 72 | 590101 | 13427 | 55688467 |
Brain oedema | 20.87 | 10.51 | 222 | 589951 | 13049 | 55688845 |
Tongue disorder | 20.81 | 10.51 | 178 | 589995 | 9858 | 55692036 |
Complication of device insertion | 20.74 | 10.51 | 22 | 590151 | 6402 | 55695492 |
Multiple drug therapy | 20.30 | 10.51 | 70 | 590103 | 2722 | 55699172 |
Invasive ductal breast carcinoma | 20.27 | 10.51 | 25 | 590148 | 6801 | 55695093 |
Pneumonia aspiration | 20.05 | 10.51 | 230 | 589943 | 32181 | 55669713 |
Malaise | 19.98 | 10.51 | 3472 | 586701 | 364388 | 55337506 |
Cardiomyopathy | 19.92 | 10.51 | 95 | 590078 | 16163 | 55685731 |
Administration site erythema | 19.92 | 10.51 | 28 | 590145 | 577 | 55701317 |
Cardiac disorder | 19.76 | 10.51 | 350 | 589823 | 45537 | 55656357 |
Kidney infection | 19.65 | 10.51 | 316 | 589857 | 20409 | 55681485 |
Intermenstrual bleeding | 19.57 | 10.51 | 27 | 590146 | 7000 | 55694894 |
Administration site bruise | 19.55 | 10.51 | 21 | 590152 | 324 | 55701570 |
Epstein-Barr virus infection | 19.49 | 10.51 | 30 | 590143 | 7433 | 55694461 |
Infusion site irritation | 19.45 | 10.51 | 30 | 590143 | 674 | 55701220 |
Ventricular fibrillation | 19.34 | 10.51 | 55 | 590118 | 10897 | 55690997 |
Lung adenocarcinoma | 19.33 | 10.51 | 12 | 590161 | 4562 | 55697332 |
Metastases to central nervous system | 19.26 | 10.51 | 64 | 590109 | 12072 | 55689822 |
Rhabdomyolysis | 19.18 | 10.51 | 305 | 589868 | 40353 | 55661541 |
Low turnover osteopathy | 19.15 | 10.51 | 9 | 590164 | 3999 | 55697895 |
Product residue present | 18.96 | 10.51 | 8 | 590165 | 3787 | 55698107 |
Mitral valve incompetence | 18.94 | 10.51 | 112 | 590061 | 18041 | 55683853 |
Serum sickness-like reaction | 18.84 | 10.51 | 24 | 590149 | 448 | 55701446 |
Left ventricular dysfunction | 18.82 | 10.51 | 57 | 590116 | 11066 | 55690828 |
Cardiotoxicity | 18.80 | 10.51 | 32 | 590141 | 7618 | 55694276 |
Treatment failure | 18.79 | 10.51 | 1534 | 588639 | 168858 | 55533036 |
Shoulder arthroplasty | 18.77 | 10.51 | 83 | 590090 | 3630 | 55698264 |
Pericardial effusion | 18.76 | 10.51 | 188 | 589985 | 26987 | 55674907 |
Secondary amyloidosis | 18.75 | 10.51 | 12 | 590161 | 84 | 55701810 |
Aphasia | 18.75 | 10.51 | 216 | 589957 | 30199 | 55671695 |
Arrhythmia | 18.69 | 10.51 | 257 | 589916 | 34826 | 55667068 |
Graft versus host disease in skin | 18.64 | 10.51 | 3 | 590170 | 2704 | 55699190 |
Drug level below therapeutic | 18.57 | 10.51 | 92 | 590081 | 4221 | 55697673 |
Therapeutic response unexpected | 18.40 | 10.51 | 104 | 590069 | 16940 | 55684954 |
Spinal fracture | 18.40 | 10.51 | 99 | 590074 | 16325 | 55685569 |
Carpal tunnel syndrome | 18.38 | 10.51 | 113 | 590060 | 18031 | 55683863 |
Pain in jaw | 18.33 | 10.51 | 302 | 589871 | 39734 | 55662160 |
Status epilepticus | 18.25 | 10.51 | 89 | 590084 | 15052 | 55686842 |
Galactorrhoea | 18.23 | 10.51 | 9 | 590164 | 3886 | 55698008 |
Nitrite urine present | 18.17 | 10.51 | 36 | 590137 | 993 | 55700901 |
Hypomania | 17.96 | 10.51 | 100 | 590073 | 4802 | 55697092 |
Specific gravity urine increased | 17.94 | 10.51 | 16 | 590157 | 194 | 55701700 |
Jaundice cholestatic | 17.89 | 10.51 | 109 | 590064 | 5410 | 55696484 |
Drug withdrawal syndrome | 17.80 | 10.51 | 179 | 589994 | 25678 | 55676216 |
Injection site induration | 17.74 | 10.51 | 40 | 590133 | 8575 | 55693319 |
Extrapyramidal disorder | 17.72 | 10.51 | 68 | 590105 | 12288 | 55689606 |
Coagulation factor X level decreased | 17.66 | 10.51 | 11 | 590162 | 73 | 55701821 |
Bone pain | 17.63 | 10.51 | 396 | 589777 | 49789 | 55652105 |
Congestive cardiomyopathy | 17.61 | 10.51 | 21 | 590152 | 5798 | 55696096 |
Varicella zoster virus infection | 17.49 | 10.51 | 3 | 590170 | 2581 | 55699313 |
General physical health deterioration | 17.48 | 10.51 | 1539 | 588634 | 168471 | 55533423 |
Forced expiratory volume decreased | 17.36 | 10.51 | 14 | 590159 | 4646 | 55697248 |
Product adhesion issue | 17.29 | 10.51 | 13 | 590160 | 4470 | 55697424 |
Vein rupture | 17.29 | 10.51 | 36 | 590137 | 1030 | 55700864 |
Device leakage | 17.25 | 10.51 | 25 | 590148 | 6350 | 55695544 |
Coeliac disease | 17.22 | 10.51 | 175 | 589998 | 10164 | 55691730 |
Infusion site streaking | 17.21 | 10.51 | 23 | 590150 | 451 | 55701443 |
Rheumatoid arthritis | 17.18 | 10.51 | 3647 | 586526 | 378957 | 55322937 |
Lumbar vertebral fracture | 17.17 | 10.51 | 16 | 590157 | 4948 | 55696946 |
Blood iron abnormal | 17.06 | 10.51 | 7 | 590166 | 3370 | 55698524 |
Dysgeusia | 17.01 | 10.51 | 314 | 589859 | 40601 | 55661293 |
Oropharyngeal discomfort | 16.94 | 10.51 | 92 | 590081 | 4376 | 55697518 |
Obstructive airways disorder | 16.80 | 10.51 | 109 | 590064 | 17173 | 55684721 |
Ketoacidosis | 16.80 | 10.51 | 11 | 590162 | 4064 | 55697830 |
Aspergillus infection | 16.77 | 10.51 | 33 | 590140 | 7432 | 55694462 |
Disturbance in attention | 16.76 | 10.51 | 240 | 589933 | 32300 | 55669594 |
Cardiac failure chronic | 16.74 | 10.51 | 11 | 590162 | 4056 | 55697838 |
Blood creatinine decreased | 16.73 | 10.51 | 102 | 590071 | 5064 | 55696830 |
Hepatic function abnormal | 16.72 | 10.51 | 258 | 589915 | 34300 | 55667594 |
Ankylosing spondylitis | 16.72 | 10.51 | 51 | 590122 | 9879 | 55692015 |
Adrenergic syndrome | 16.60 | 10.51 | 8 | 590165 | 29 | 55701865 |
Toxic skin eruption | 16.58 | 10.51 | 65 | 590108 | 11674 | 55690220 |
Personality change | 16.56 | 10.51 | 22 | 590151 | 5795 | 55696099 |
Coagulation factor VII level decreased | 16.52 | 10.51 | 11 | 590162 | 83 | 55701811 |
Drug reaction with eosinophilia and systemic symptoms | 16.50 | 10.51 | 221 | 589952 | 30083 | 55671811 |
Ejection fraction decreased | 16.44 | 10.51 | 131 | 590042 | 19710 | 55682184 |
Angina pectoris | 16.35 | 10.51 | 201 | 589972 | 27775 | 55674119 |
Human herpesvirus 6 infection | 16.32 | 10.51 | 4 | 590169 | 2678 | 55699216 |
Dysphoria | 16.29 | 10.51 | 16 | 590157 | 4826 | 55697068 |
Drug specific antibody present | 16.29 | 10.51 | 79 | 590094 | 3593 | 55698301 |
Pre-eclampsia | 16.21 | 10.51 | 41 | 590132 | 8445 | 55693449 |
Lupus-like syndrome | 16.19 | 10.51 | 71 | 590102 | 12356 | 55689538 |
Haematuria | 16.11 | 10.51 | 193 | 589980 | 26794 | 55675100 |
Large intestine polyp | 16.05 | 10.51 | 35 | 590138 | 7592 | 55694302 |
Device deployment issue | 16.03 | 10.51 | 9 | 590164 | 3615 | 55698279 |
Malignant melanoma | 16.02 | 10.51 | 58 | 590115 | 10661 | 55691233 |
Cytomegalovirus viraemia | 16.01 | 10.51 | 18 | 590155 | 5102 | 55696792 |
Lactobacillus infection | 16.01 | 10.51 | 9 | 590164 | 48 | 55701846 |
Thyroid cancer | 15.98 | 10.51 | 18 | 590155 | 5098 | 55696796 |
Infusion site warmth | 15.98 | 10.51 | 43 | 590130 | 1457 | 55700437 |
Systemic lupus erythematosus rash | 15.97 | 10.51 | 51 | 590122 | 1905 | 55699989 |
Infusion site scar | 15.96 | 10.51 | 20 | 590153 | 367 | 55701527 |
Infective pulmonary exacerbation of cystic fibrosis | 15.90 | 10.51 | 39 | 590134 | 8118 | 55693776 |
Hypervolaemia | 15.88 | 10.51 | 189 | 589984 | 26269 | 55675625 |
Concomitant disease aggravated | 15.87 | 10.51 | 41 | 590132 | 8385 | 55693509 |
Death | 15.80 | 10.51 | 3920 | 586253 | 337506 | 55364388 |
Pulmonary alveolar haemorrhage | 15.65 | 10.51 | 13 | 590160 | 4251 | 55697643 |
Periorbital swelling | 15.61 | 10.51 | 56 | 590117 | 2222 | 55699672 |
Body height decreased | 15.59 | 10.51 | 47 | 590126 | 9138 | 55692756 |
Joint dislocation | 15.58 | 10.51 | 99 | 590074 | 15674 | 55686220 |
Aspartate aminotransferase increased | 15.53 | 10.51 | 1035 | 589138 | 81567 | 55620327 |
Acute respiratory failure | 15.47 | 10.51 | 230 | 589943 | 30764 | 55671130 |
Anuria | 15.43 | 10.51 | 67 | 590106 | 11693 | 55690201 |
Thinking abnormal | 15.38 | 10.51 | 53 | 590120 | 9888 | 55692006 |
Rhinitis allergic | 15.38 | 10.51 | 42 | 590131 | 8432 | 55693462 |
Spinal compression fracture | 15.37 | 10.51 | 78 | 590095 | 13056 | 55688838 |
Cardiogenic shock | 15.35 | 10.51 | 104 | 590069 | 16221 | 55685673 |
Neutrophil count decreased | 15.35 | 10.51 | 401 | 589772 | 49421 | 55652473 |
Dizziness | 15.33 | 10.51 | 3602 | 586571 | 372538 | 55329356 |
Monocyte percentage increased | 15.33 | 10.51 | 35 | 590138 | 1068 | 55700826 |
Visual impairment | 15.29 | 10.51 | 629 | 589544 | 73573 | 55628321 |
Administration site reaction | 15.28 | 10.51 | 15 | 590158 | 207 | 55701687 |
Femoral neck fracture | 15.27 | 10.51 | 37 | 590136 | 7734 | 55694160 |
Eosinophil percentage increased | 15.23 | 10.51 | 33 | 590140 | 971 | 55700923 |
Blood loss anaemia | 15.15 | 10.51 | 41 | 590132 | 8256 | 55693638 |
Ductus arteriosus premature closure | 15.15 | 10.51 | 18 | 590155 | 312 | 55701582 |
Bradyphrenia | 15.10 | 10.51 | 29 | 590144 | 6591 | 55695303 |
Vertigo | 15.07 | 10.51 | 446 | 589727 | 54126 | 55647768 |
Glycosylated haemoglobin increased | 15.03 | 10.51 | 63 | 590110 | 11102 | 55690792 |
Aplasia pure red cell | 15.02 | 10.51 | 14 | 590159 | 4328 | 55697566 |
Low density lipoprotein increased | 14.97 | 10.51 | 24 | 590149 | 5850 | 55696044 |
Schizoaffective disorder | 14.97 | 10.51 | 66 | 590107 | 2883 | 55699011 |
Coma | 14.95 | 10.51 | 767 | 589406 | 58888 | 55643006 |
Nephropathy toxic | 14.93 | 10.51 | 43 | 590130 | 8484 | 55693410 |
Akathisia | 14.88 | 10.51 | 44 | 590129 | 8608 | 55693286 |
Drug ineffective for unapproved indication | 14.87 | 10.51 | 185 | 589988 | 25508 | 55676386 |
Vision blurred | 14.85 | 10.51 | 714 | 589459 | 82229 | 55619665 |
Genital haemorrhage | 14.85 | 10.51 | 31 | 590142 | 6831 | 55695063 |
Skin cancer | 14.84 | 10.51 | 57 | 590116 | 10298 | 55691596 |
Uterine cancer | 14.84 | 10.51 | 15 | 590158 | 4464 | 55697430 |
Migraine | 14.83 | 10.51 | 1079 | 589094 | 85718 | 55616176 |
Pulmonary tuberculosis | 14.82 | 10.51 | 15 | 590158 | 4461 | 55697433 |
Product monitoring error | 14.72 | 10.51 | 9 | 590164 | 3450 | 55698444 |
Latent tuberculosis | 14.71 | 10.51 | 4 | 590169 | 2498 | 55699396 |
Exostosis | 14.65 | 10.51 | 94 | 590079 | 14849 | 55687045 |
Sinus bradycardia | 14.62 | 10.51 | 83 | 590090 | 13503 | 55688391 |
Angina unstable | 14.60 | 10.51 | 31 | 590142 | 6790 | 55695104 |
Long QT syndrome | 14.56 | 10.51 | 7 | 590166 | 3069 | 55698825 |
Cystic fibrosis pancreatic | 14.53 | 10.51 | 9 | 590164 | 59 | 55701835 |
Amenorrhoea | 14.53 | 10.51 | 47 | 590126 | 8939 | 55692955 |
Renal papillary necrosis | 14.45 | 10.51 | 15 | 590158 | 222 | 55701672 |
Melaena | 14.45 | 10.51 | 209 | 589964 | 28081 | 55673813 |
Vaginal flatulence | 14.42 | 10.51 | 26 | 590147 | 667 | 55701227 |
Unintended pregnancy | 14.40 | 10.51 | 20 | 590153 | 5171 | 55696723 |
Heavy menstrual bleeding | 14.39 | 10.51 | 105 | 590068 | 16104 | 55685790 |
Sleep disorder due to a general medical condition | 14.38 | 10.51 | 48 | 590125 | 9042 | 55692852 |
Pancreatitis | 14.37 | 10.51 | 361 | 589812 | 44719 | 55657175 |
Urticaria thermal | 14.35 | 10.51 | 16 | 590157 | 258 | 55701636 |
Cardiovascular disorder | 14.31 | 10.51 | 62 | 590111 | 10827 | 55691067 |
Vascular rupture | 14.30 | 10.51 | 42 | 590131 | 1498 | 55700396 |
Haemarthrosis | 14.29 | 10.51 | 7 | 590166 | 3037 | 55698857 |
Taste disorder | 14.23 | 10.51 | 53 | 590120 | 9662 | 55692232 |
Left ventricular failure | 14.11 | 10.51 | 19 | 590154 | 4977 | 55696917 |
Compartment syndrome | 14.08 | 10.51 | 50 | 590123 | 1974 | 55699920 |
Myopathy | 14.07 | 10.51 | 54 | 590119 | 9758 | 55692136 |
Cellulitis | 14.06 | 10.51 | 642 | 589531 | 74307 | 55627587 |
Focal dyscognitive seizures | 14.04 | 10.51 | 6 | 590167 | 2819 | 55699075 |
Product dispensing error | 13.93 | 10.51 | 50 | 590123 | 9214 | 55692680 |
Small for dates baby | 13.92 | 10.51 | 10 | 590163 | 3520 | 55698374 |
Complication of device removal | 13.91 | 10.51 | 16 | 590157 | 4488 | 55697406 |
Cells in urine | 13.77 | 10.51 | 14 | 590159 | 202 | 55701692 |
Peripheral sensory neuropathy | 13.76 | 10.51 | 33 | 590140 | 6923 | 55694971 |
Hallucination, auditory | 13.74 | 10.51 | 68 | 590105 | 11456 | 55690438 |
Blood thyroid stimulating hormone decreased | 13.68 | 10.51 | 85 | 590088 | 4248 | 55697646 |
Wrong patient received product | 13.68 | 10.51 | 3 | 590170 | 2168 | 55699726 |
Liver transplant | 13.68 | 10.51 | 53 | 590120 | 2183 | 55699711 |
Spinal pain | 13.67 | 10.51 | 71 | 590102 | 11813 | 55690081 |
Ovarian hyperstimulation syndrome | 13.66 | 10.51 | 11 | 590162 | 3653 | 55698241 |
Skin toxicity | 13.66 | 10.51 | 14 | 590159 | 4139 | 55697755 |
Impaired work ability | 13.62 | 10.51 | 93 | 590080 | 14479 | 55687415 |
Mucormycosis | 13.61 | 10.51 | 6 | 590167 | 2768 | 55699126 |
Gallbladder injury | 13.58 | 10.51 | 37 | 590136 | 1263 | 55700631 |
Mean cell haemoglobin concentration increased | 13.58 | 10.51 | 21 | 590152 | 473 | 55701421 |
Hemiplegia | 13.56 | 10.51 | 44 | 590129 | 8360 | 55693534 |
Electric shock sensation | 13.48 | 10.51 | 21 | 590152 | 476 | 55701418 |
Urinary casts | 13.45 | 10.51 | 26 | 590147 | 704 | 55701190 |
Renal failure neonatal | 13.44 | 10.51 | 13 | 590160 | 176 | 55701718 |
Peritonitis | 13.42 | 10.51 | 107 | 590066 | 16095 | 55685799 |
Pancreatitis acute | 13.40 | 10.51 | 184 | 589989 | 24940 | 55676954 |
Pulmonary infarction | 13.35 | 10.51 | 57 | 590116 | 2455 | 55699439 |
Mean cell haemoglobin concentration decreased | 13.35 | 10.51 | 68 | 590105 | 3155 | 55698739 |
Osmolar gap | 13.17 | 10.51 | 10 | 590163 | 95 | 55701799 |
Oropharyngeal spasm | 13.15 | 10.51 | 13 | 590160 | 181 | 55701713 |
Immunosuppressant drug level increased | 13.12 | 10.51 | 9 | 590164 | 3244 | 55698650 |
Prothrombin time prolonged | 13.07 | 10.51 | 149 | 590024 | 8911 | 55692983 |
Meniscus injury | 13.06 | 10.51 | 31 | 590142 | 6527 | 55695367 |
Caesarean section | 12.99 | 10.51 | 107 | 590066 | 15984 | 55685910 |
Coronary artery bypass | 12.95 | 10.51 | 4 | 590169 | 2299 | 55699595 |
Haematoma | 12.92 | 10.51 | 247 | 589926 | 31772 | 55670122 |
Drug-induced liver injury | 12.89 | 10.51 | 462 | 589711 | 34000 | 55667894 |
Intervertebral discitis | 12.89 | 10.51 | 61 | 590112 | 2746 | 55699148 |
Anoxia | 12.89 | 10.51 | 14 | 590159 | 219 | 55701675 |
Thyroxine free increased | 12.86 | 10.51 | 28 | 590145 | 827 | 55701067 |
Disorientation | 12.83 | 10.51 | 289 | 589884 | 36324 | 55665570 |
Cystitis | 12.81 | 10.51 | 633 | 589540 | 48405 | 55653489 |
Oesophageal carcinoma | 12.78 | 10.51 | 3 | 590170 | 2068 | 55699826 |
Movement disorder | 12.76 | 10.51 | 134 | 590039 | 19064 | 55682830 |
Brain stem glioma | 12.74 | 10.51 | 14 | 590159 | 222 | 55701672 |
Post procedural pulmonary embolism | 12.67 | 10.51 | 15 | 590158 | 259 | 55701635 |
Withdrawal syndrome | 12.63 | 10.51 | 128 | 590045 | 18334 | 55683560 |
Loss of consciousness | 12.58 | 10.51 | 981 | 589192 | 108368 | 55593526 |
Corneal reflex decreased | 12.56 | 10.51 | 11 | 590162 | 130 | 55701764 |
Blindness | 12.48 | 10.51 | 128 | 590045 | 18293 | 55683601 |
Injection site extravasation | 12.45 | 10.51 | 136 | 590037 | 8048 | 55693846 |
Oedema | 12.44 | 10.51 | 717 | 589456 | 81203 | 55620691 |
Nervous system disorder | 12.44 | 10.51 | 115 | 590058 | 16774 | 55685120 |
Injection site discolouration | 12.42 | 10.51 | 37 | 590136 | 7222 | 55694672 |
Anxiety | 12.40 | 10.51 | 2253 | 587920 | 190919 | 55510975 |
Product physical issue | 12.37 | 10.51 | 18 | 590155 | 4564 | 55697330 |
Transfusion-related acute lung injury | 12.36 | 10.51 | 10 | 590163 | 105 | 55701789 |
Administration site pruritus | 12.32 | 10.51 | 15 | 590158 | 267 | 55701627 |
Tremor | 12.32 | 10.51 | 1097 | 589076 | 119992 | 55581902 |
Enthesopathy | 12.27 | 10.51 | 134 | 590039 | 7929 | 55693965 |
Oropharyngeal pain | 12.24 | 10.51 | 1029 | 589144 | 82759 | 55619135 |
Patent ductus arteriosus | 12.24 | 10.51 | 14 | 590159 | 3937 | 55697957 |
Chondropathy | 12.21 | 10.51 | 4 | 590169 | 2213 | 55699681 |
Multiple sclerosis relapse | 12.15 | 10.51 | 368 | 589805 | 44535 | 55657359 |
Low birth weight baby | 12.14 | 10.51 | 30 | 590143 | 6228 | 55695666 |
Multiple fractures | 12.11 | 10.51 | 124 | 590049 | 7217 | 55694677 |
Intentional dose omission | 12.08 | 10.51 | 29 | 590144 | 6081 | 55695813 |
Graft versus host disease in gastrointestinal tract | 12.03 | 10.51 | 8 | 590165 | 2931 | 55698963 |
Device breakage | 12.02 | 10.51 | 60 | 590113 | 10087 | 55691807 |
Myelocyte count increased | 12.00 | 10.51 | 17 | 590156 | 353 | 55701541 |
Vein collapse | 11.97 | 10.51 | 28 | 590145 | 868 | 55701026 |
Muscle twitching | 11.97 | 10.51 | 238 | 589935 | 16004 | 55685890 |
Band neutrophil count increased | 11.96 | 10.51 | 17 | 590156 | 354 | 55701540 |
Impaired quality of life | 11.92 | 10.51 | 47 | 590126 | 8427 | 55693467 |
Infusion site discolouration | 11.90 | 10.51 | 24 | 590149 | 671 | 55701223 |
Accidental exposure to product by child | 11.87 | 10.51 | 33 | 590140 | 1140 | 55700754 |
Petit mal epilepsy | 11.84 | 10.51 | 12 | 590161 | 3566 | 55698328 |
Asthenia | 11.82 | 10.51 | 3309 | 586864 | 339664 | 55362230 |
Vasodilation procedure | 11.82 | 10.51 | 6 | 590167 | 25 | 55701869 |
Transfusion | 11.80 | 10.51 | 88 | 590085 | 13432 | 55688462 |
Contraindicated product administered | 11.77 | 10.51 | 2171 | 588002 | 184115 | 55517779 |
Upper gastrointestinal haemorrhage | 11.76 | 10.51 | 118 | 590055 | 16936 | 55684958 |
Vitamin D deficiency | 11.71 | 10.51 | 77 | 590096 | 12093 | 55689801 |
Fluid retention | 11.66 | 10.51 | 456 | 589717 | 53622 | 55648272 |
Premature rupture of membranes | 11.65 | 10.51 | 20 | 590153 | 4745 | 55697149 |
Creatinine urine decreased | 11.65 | 10.51 | 12 | 590161 | 176 | 55701718 |
Coronary arterial stent insertion | 11.61 | 10.51 | 7 | 590166 | 2703 | 55699191 |
Circulatory collapse | 11.59 | 10.51 | 151 | 590022 | 20652 | 55681242 |
Administration site extravasation | 11.55 | 10.51 | 25 | 590148 | 735 | 55701159 |
Affective disorder | 11.55 | 10.51 | 26 | 590147 | 5577 | 55696317 |
Psychomotor skills impaired | 11.54 | 10.51 | 4 | 590169 | 2136 | 55699758 |
Tri-iodothyronine free increased | 11.50 | 10.51 | 13 | 590160 | 213 | 55701681 |
Erysipelas | 11.47 | 10.51 | 38 | 590135 | 7175 | 55694719 |
Hepatitis C | 11.45 | 10.51 | 26 | 590147 | 5560 | 55696334 |
Lymphoproliferative disorder | 11.40 | 10.51 | 9 | 590164 | 3019 | 55698875 |
Blood creatine increased | 11.39 | 10.51 | 93 | 590080 | 5080 | 55696814 |
Red blood cells urine | 11.36 | 10.51 | 20 | 590153 | 503 | 55701391 |
Neuroleptic malignant syndrome | 11.36 | 10.51 | 72 | 590101 | 11406 | 55690488 |
Device related thrombosis | 11.35 | 10.51 | 40 | 590133 | 1573 | 55700321 |
Hallucinations, mixed | 11.35 | 10.51 | 18 | 590155 | 4406 | 55697488 |
Stress fracture | 11.29 | 10.51 | 38 | 590135 | 7139 | 55694755 |
Sputum culture positive | 11.28 | 10.51 | 42 | 590131 | 1697 | 55700197 |
Cytomegalovirus infection reactivation | 11.27 | 10.51 | 10 | 590163 | 3166 | 55698728 |
Somnolence | 11.25 | 10.51 | 1913 | 588260 | 161500 | 55540394 |
Squamous cell carcinoma of skin | 11.19 | 10.51 | 25 | 590148 | 5377 | 55696517 |
COVID-19 immunisation | 11.16 | 10.51 | 37 | 590136 | 1410 | 55700484 |
Catheter management | 11.15 | 10.51 | 8 | 590165 | 2818 | 55699076 |
Dyslipidaemia | 11.15 | 10.51 | 32 | 590141 | 6321 | 55695573 |
Band neutrophil percentage increased | 11.13 | 10.51 | 13 | 590160 | 221 | 55701673 |
Partial seizures | 11.12 | 10.51 | 25 | 590148 | 5365 | 55696529 |
Pupil fixed | 11.12 | 10.51 | 41 | 590132 | 1649 | 55700245 |
Feeling cold | 11.12 | 10.51 | 296 | 589877 | 20891 | 55681003 |
Limb mass | 11.10 | 10.51 | 61 | 590112 | 2915 | 55698979 |
Blood prolactin increased | 11.06 | 10.51 | 11 | 590162 | 3298 | 55698596 |
Leukoencephalopathy | 11.06 | 10.51 | 16 | 590157 | 4066 | 55697828 |
Product complaint | 11.01 | 10.51 | 75 | 590098 | 11685 | 55690209 |
Mastocytosis | 10.98 | 10.51 | 20 | 590153 | 517 | 55701377 |
Hyperammonaemia | 10.96 | 10.51 | 22 | 590151 | 4918 | 55696976 |
Potentiating drug interaction | 10.95 | 10.51 | 16 | 590157 | 4050 | 55697844 |
Pharyngeal swelling | 10.94 | 10.51 | 94 | 590079 | 5212 | 55696682 |
Kidney transplant rejection | 10.94 | 10.51 | 17 | 590156 | 4196 | 55697698 |
Malnutrition | 10.92 | 10.51 | 94 | 590079 | 13914 | 55687980 |
Disseminated tuberculosis | 10.83 | 10.51 | 8 | 590165 | 2775 | 55699119 |
Maternal exposure before pregnancy | 10.82 | 10.51 | 36 | 590137 | 6787 | 55695107 |
Ear swelling | 10.81 | 10.51 | 33 | 590140 | 1203 | 55700691 |
Normal newborn | 10.78 | 10.51 | 41 | 590132 | 7429 | 55694465 |
Intramedullary rod insertion | 10.78 | 10.51 | 4 | 590169 | 2047 | 55699847 |
Post-traumatic stress disorder | 10.77 | 10.51 | 83 | 590090 | 4455 | 55697439 |
Maculopathy | 10.72 | 10.51 | 4 | 590169 | 2040 | 55699854 |
White blood cells urine | 10.72 | 10.51 | 16 | 590157 | 349 | 55701545 |
Condition aggravated | 10.71 | 10.51 | 3342 | 586831 | 341556 | 55360338 |
Dyskinesia | 10.71 | 10.51 | 228 | 589945 | 28880 | 55673014 |
Perineal rash | 10.71 | 10.51 | 3 | 590170 | 0 | 55701894 |
Analgesic drug level below therapeutic | 10.71 | 10.51 | 3 | 590170 | 0 | 55701894 |
Hypomagnesaemia | 10.71 | 10.51 | 191 | 589982 | 24824 | 55677070 |
Oocyte harvest | 10.71 | 10.51 | 3 | 590170 | 0 | 55701894 |
Sucrose intolerance | 10.71 | 10.51 | 3 | 590170 | 0 | 55701894 |
Pregnancy | 10.67 | 10.51 | 264 | 589909 | 32769 | 55669125 |
Adenovirus infection | 10.64 | 10.51 | 12 | 590161 | 3396 | 55698498 |
Dissociation | 10.63 | 10.51 | 7 | 590166 | 2578 | 55699316 |
Pneumothorax | 10.62 | 10.51 | 102 | 590071 | 14765 | 55687129 |
Back pain | 10.59 | 10.51 | 2719 | 587454 | 234451 | 55467443 |
Dysstasia | 10.59 | 10.51 | 141 | 590032 | 19213 | 55682681 |
Mucosal dryness | 10.55 | 10.51 | 53 | 590120 | 2445 | 55699449 |
Ductus arteriosus stenosis foetal | 10.54 | 10.51 | 11 | 590162 | 164 | 55701730 |
Dysmorphism | 10.53 | 10.51 | 5 | 590168 | 2208 | 55699686 |
Procedural anxiety | 10.52 | 10.51 | 23 | 590150 | 681 | 55701213 |
Intestinal haemorrhage | 10.52 | 10.51 | 13 | 590160 | 3533 | 55698361 |
Infusion site induration | 10.51 | 10.51 | 27 | 590146 | 889 | 55701005 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1761.54 | 10.72 | 2763 | 237129 | 88751 | 31368701 |
Toxicity to various agents | 1753.09 | 10.72 | 4082 | 235810 | 177405 | 31280047 |
Infusion related reaction | 1194.16 | 10.72 | 1638 | 238254 | 46417 | 31411035 |
Drug abuse | 520.44 | 10.72 | 1653 | 238239 | 86105 | 31371347 |
Blood pressure fluctuation | 395.80 | 10.72 | 657 | 239235 | 22079 | 31435373 |
Intentional product misuse | 389.90 | 10.72 | 877 | 239015 | 37074 | 31420378 |
Overdose | 317.55 | 10.72 | 1376 | 238516 | 83288 | 31374164 |
Urticaria | 299.23 | 10.72 | 1037 | 238855 | 56480 | 31400972 |
Exposure to toxic agent | 238.47 | 10.72 | 180 | 239712 | 2415 | 31455037 |
Drug ineffective | 232.86 | 10.72 | 1899 | 237993 | 393674 | 31063778 |
Respiratory arrest | 230.70 | 10.72 | 571 | 239321 | 25686 | 31431766 |
Blood pressure increased | 221.62 | 10.72 | 1188 | 238704 | 78445 | 31379007 |
Intentional overdose | 211.51 | 10.72 | 742 | 239150 | 40647 | 31416805 |
Flushing | 209.79 | 10.72 | 601 | 239291 | 29527 | 31427925 |
Chills | 201.44 | 10.72 | 1099 | 238793 | 73051 | 31384401 |
Heart rate decreased | 197.91 | 10.72 | 565 | 239327 | 27701 | 31429751 |
Acute hepatic failure | 176.54 | 10.72 | 335 | 239557 | 12524 | 31444928 |
Oxygen saturation decreased | 162.08 | 10.72 | 769 | 239123 | 48346 | 31409106 |
Cardio-respiratory arrest | 141.30 | 10.72 | 768 | 239124 | 50958 | 31406494 |
Myocardial infarction | 132.35 | 10.72 | 429 | 239463 | 113025 | 31344427 |
Heart rate increased | 130.08 | 10.72 | 636 | 239256 | 40474 | 31416978 |
Blood pressure diastolic abnormal | 124.22 | 10.72 | 152 | 239740 | 3827 | 31453625 |
Accidental overdose | 123.80 | 10.72 | 362 | 239530 | 17988 | 31439464 |
Respiratory depression | 123.69 | 10.72 | 312 | 239580 | 14198 | 31443254 |
Cardiac failure | 123.29 | 10.72 | 294 | 239598 | 85659 | 31371793 |
Drug resistance | 118.36 | 10.72 | 18 | 239874 | 23435 | 31434017 |
Blood pressure systolic increased | 117.19 | 10.72 | 369 | 239523 | 19101 | 31438351 |
Exposure via ingestion | 116.28 | 10.72 | 107 | 239785 | 1918 | 31455534 |
Drug interaction | 112.80 | 10.72 | 1022 | 238870 | 207521 | 31249931 |
Sinusitis | 111.33 | 10.72 | 561 | 239331 | 36135 | 31421317 |
Cardiac failure congestive | 106.49 | 10.72 | 281 | 239611 | 79106 | 31378346 |
Pruritus | 99.35 | 10.72 | 1412 | 238480 | 123755 | 31333697 |
Anaemia | 94.61 | 10.72 | 1097 | 238795 | 212425 | 31245027 |
Poisoning | 94.45 | 10.72 | 229 | 239663 | 10162 | 31447290 |
Anion gap | 92.90 | 10.72 | 62 | 239830 | 675 | 31456777 |
Intentional product use issue | 91.17 | 10.72 | 663 | 239229 | 48684 | 31408768 |
Anaphylactic reaction | 89.07 | 10.72 | 451 | 239441 | 29102 | 31428350 |
Product dose omission issue | 80.94 | 10.72 | 468 | 239424 | 105118 | 31352334 |
Blood pressure systolic abnormal | 79.20 | 10.72 | 107 | 239785 | 2980 | 31454472 |
Cardiac arrest | 78.10 | 10.72 | 1023 | 238869 | 88039 | 31369413 |
Unresponsive to stimuli | 77.24 | 10.72 | 393 | 239499 | 25407 | 31432045 |
Diarrhoea | 76.33 | 10.72 | 2058 | 237834 | 350351 | 31107101 |
Psoriasis | 75.91 | 10.72 | 149 | 239743 | 46570 | 31410882 |
Throat tightness | 74.01 | 10.72 | 173 | 239719 | 7496 | 31449956 |
Heart rate irregular | 73.66 | 10.72 | 257 | 239635 | 14032 | 31443420 |
Cytokine release syndrome | 72.92 | 10.72 | 284 | 239608 | 16358 | 31441094 |
Renal impairment | 72.07 | 10.72 | 372 | 239520 | 85977 | 31371475 |
Suspected suicide | 69.18 | 10.72 | 117 | 239775 | 3990 | 31453462 |
Hepatic cytolysis | 68.72 | 10.72 | 209 | 239683 | 10614 | 31446838 |
Throat irritation | 67.93 | 10.72 | 189 | 239703 | 9125 | 31448327 |
Blood pressure diastolic increased | 67.10 | 10.72 | 118 | 239774 | 4155 | 31453297 |
Infusion site swelling | 64.56 | 10.72 | 80 | 239812 | 2041 | 31455411 |
Infusion site extravasation | 64.46 | 10.72 | 106 | 239786 | 3531 | 31453921 |
Metabolic acidosis | 64.28 | 10.72 | 516 | 239376 | 39061 | 31418391 |
Erythema | 64.10 | 10.72 | 908 | 238984 | 79497 | 31377955 |
Acute kidney injury | 61.11 | 10.72 | 1631 | 238261 | 278083 | 31179369 |
Interstitial lung disease | 61.07 | 10.72 | 248 | 239644 | 61155 | 31396297 |
Plasma cell myeloma | 60.94 | 10.72 | 221 | 239671 | 56310 | 31401142 |
General physical health deterioration | 60.29 | 10.72 | 558 | 239334 | 112877 | 31344575 |
Foetal exposure during pregnancy | 60.02 | 10.72 | 138 | 239754 | 40738 | 31416714 |
Environmental exposure | 58.42 | 10.72 | 32 | 239860 | 235 | 31457217 |
Analgesic drug level increased | 58.20 | 10.72 | 45 | 239847 | 627 | 31456825 |
Tachycardia | 56.56 | 10.72 | 850 | 239042 | 75357 | 31382095 |
Infusion site pain | 56.23 | 10.72 | 93 | 239799 | 3113 | 31454339 |
Therapeutic product effect incomplete | 53.87 | 10.72 | 161 | 239731 | 43535 | 31413917 |
Prostate cancer | 53.56 | 10.72 | 129 | 239763 | 37472 | 31419980 |
Blood pressure diastolic decreased | 52.06 | 10.72 | 156 | 239736 | 7857 | 31449595 |
Body temperature increased | 51.79 | 10.72 | 240 | 239652 | 14933 | 31442519 |
Cerebral haemorrhage | 51.28 | 10.72 | 107 | 239785 | 32705 | 31424747 |
Body temperature decreased | 50.87 | 10.72 | 200 | 239692 | 11570 | 31445882 |
Coagulopathy | 49.91 | 10.72 | 274 | 239618 | 18241 | 31439211 |
Wrong technique in product usage process | 47.01 | 10.72 | 115 | 239777 | 33228 | 31424224 |
Coronary artery disease | 46.54 | 10.72 | 185 | 239707 | 45902 | 31411550 |
Infusion site erythema | 46.39 | 10.72 | 64 | 239828 | 1819 | 31455633 |
Inappropriate schedule of product administration | 45.44 | 10.72 | 586 | 239306 | 50237 | 31407215 |
Malignant neoplasm progression | 44.85 | 10.72 | 382 | 239510 | 78616 | 31378836 |
Diabetes mellitus | 44.79 | 10.72 | 168 | 239724 | 42388 | 31415064 |
Bone marrow failure | 44.05 | 10.72 | 91 | 239801 | 27917 | 31429535 |
Respiratory rate increased | 43.99 | 10.72 | 162 | 239730 | 9083 | 31448369 |
Hypotension | 43.83 | 10.72 | 1930 | 237962 | 202688 | 31254764 |
Hepatic necrosis | 43.71 | 10.72 | 90 | 239802 | 3573 | 31453879 |
Substance abuse | 43.37 | 10.72 | 136 | 239756 | 7022 | 31450430 |
Pyroglutamic acidosis | 43.28 | 10.72 | 29 | 239863 | 318 | 31457134 |
Hepatotoxicity | 42.48 | 10.72 | 269 | 239623 | 18857 | 31438595 |
Suicide attempt | 42.42 | 10.72 | 450 | 239442 | 36798 | 31420654 |
Body temperature fluctuation | 41.79 | 10.72 | 56 | 239836 | 1547 | 31455905 |
Cerebrovascular accident | 40.92 | 10.72 | 394 | 239498 | 79090 | 31378362 |
Bladder cancer | 40.79 | 10.72 | 31 | 239861 | 14694 | 31442758 |
Renal cortical necrosis | 40.36 | 10.72 | 23 | 239869 | 184 | 31457268 |
Headache | 39.93 | 10.72 | 1735 | 238157 | 181917 | 31275535 |
Cerebral infarction | 39.52 | 10.72 | 86 | 239806 | 25891 | 31431561 |
Poor venous access | 39.33 | 10.72 | 92 | 239800 | 3988 | 31453464 |
Pancytopenia | 39.18 | 10.72 | 447 | 239445 | 86869 | 31370583 |
Alanine aminotransferase increased | 38.58 | 10.72 | 786 | 239106 | 73870 | 31383582 |
Medication error | 38.11 | 10.72 | 299 | 239593 | 22473 | 31434979 |
Treatment failure | 37.93 | 10.72 | 169 | 239723 | 40623 | 31416829 |
Aspartate aminotransferase increased | 37.77 | 10.72 | 676 | 239216 | 62043 | 31395409 |
Poisoning deliberate | 37.77 | 10.72 | 132 | 239760 | 7212 | 31450240 |
Hypersensitivity | 37.63 | 10.72 | 612 | 239280 | 55131 | 31402321 |
Labelled drug-drug interaction medication error | 37.38 | 10.72 | 27 | 239865 | 13136 | 31444316 |
Lymphocyte percentage decreased | 36.74 | 10.72 | 60 | 239832 | 1987 | 31455465 |
Neutrophil percentage increased | 35.64 | 10.72 | 55 | 239837 | 1734 | 31455718 |
Injection site pain | 35.62 | 10.72 | 138 | 239754 | 34496 | 31422956 |
Fall | 35.50 | 10.72 | 1105 | 238787 | 184984 | 31272468 |
Drug hypersensitivity | 35.12 | 10.72 | 757 | 239135 | 71842 | 31385610 |
Infusion site pruritus | 34.94 | 10.72 | 32 | 239860 | 570 | 31456882 |
Hospitalisation | 34.87 | 10.72 | 227 | 239665 | 49580 | 31407872 |
Tongue disorder | 34.82 | 10.72 | 100 | 239792 | 4917 | 31452535 |
Osteonecrosis of jaw | 34.69 | 10.72 | 47 | 239845 | 17024 | 31440428 |
Ear infection | 34.48 | 10.72 | 146 | 239746 | 8735 | 31448717 |
Sopor | 33.72 | 10.72 | 23 | 239869 | 11529 | 31445923 |
Febrile neutropenia | 33.72 | 10.72 | 1182 | 238710 | 120667 | 31336785 |
Therapeutic response shortened | 33.63 | 10.72 | 109 | 239783 | 5728 | 31451724 |
Myelosuppression | 33.55 | 10.72 | 38 | 239854 | 14882 | 31442570 |
Aplastic anaemia | 33.22 | 10.72 | 148 | 239744 | 9055 | 31448397 |
Haematotoxicity | 32.72 | 10.72 | 7 | 239885 | 7130 | 31450322 |
Leukopenia | 32.65 | 10.72 | 280 | 239612 | 57548 | 31399904 |
Pulmonary oedema | 32.46 | 10.72 | 495 | 239397 | 44007 | 31413445 |
Infusion site rash | 32.10 | 10.72 | 26 | 239866 | 389 | 31457063 |
Accident | 31.16 | 10.72 | 82 | 239810 | 3829 | 31453623 |
Oesophageal carcinoma | 31.00 | 10.72 | 11 | 239881 | 8022 | 31449430 |
Hepatocellular carcinoma | 30.51 | 10.72 | 14 | 239878 | 8742 | 31448710 |
Feeling hot | 30.47 | 10.72 | 219 | 239673 | 16014 | 31441438 |
Progressive multifocal leukoencephalopathy | 30.18 | 10.72 | 16 | 239876 | 9197 | 31448255 |
Pathogen resistance | 30.18 | 10.72 | 14 | 239878 | 8687 | 31448765 |
Epilepsy | 30.11 | 10.72 | 72 | 239820 | 20969 | 31436483 |
Renal failure | 30.10 | 10.72 | 707 | 239185 | 122623 | 31334829 |
Glycosylated haemoglobin increased | 29.97 | 10.72 | 21 | 239871 | 10379 | 31447073 |
Angina pectoris | 29.91 | 10.72 | 119 | 239773 | 29522 | 31427930 |
Post transplant lymphoproliferative disorder | 29.89 | 10.72 | 5 | 239887 | 6071 | 31451381 |
Infusion site reaction | 29.70 | 10.72 | 34 | 239858 | 796 | 31456656 |
Depressed level of consciousness | 29.57 | 10.72 | 433 | 239459 | 38168 | 31419284 |
Septic shock | 29.54 | 10.72 | 339 | 239553 | 65819 | 31391633 |
Atrial fibrillation | 29.54 | 10.72 | 646 | 239246 | 113137 | 31344315 |
Visual acuity reduced | 29.43 | 10.72 | 44 | 239848 | 15299 | 31442153 |
Rash | 29.05 | 10.72 | 1831 | 238061 | 199655 | 31257797 |
Graft versus host disease | 28.93 | 10.72 | 22 | 239870 | 10425 | 31447027 |
Cytomegalovirus infection | 28.36 | 10.72 | 94 | 239798 | 24613 | 31432839 |
Hyperkalaemia | 28.24 | 10.72 | 331 | 239561 | 64020 | 31393432 |
Nasopharyngitis | 28.23 | 10.72 | 652 | 239240 | 62593 | 31394859 |
Cardiac failure chronic | 28.18 | 10.72 | 10 | 239882 | 7293 | 31450159 |
Pallor | 27.96 | 10.72 | 276 | 239616 | 22148 | 31435304 |
Lip swelling | 27.52 | 10.72 | 184 | 239708 | 13139 | 31444313 |
Pyrexia | 27.45 | 10.72 | 2662 | 237230 | 301178 | 31156274 |
Pharyngeal paraesthesia | 27.32 | 10.72 | 27 | 239865 | 531 | 31456921 |
Victim of child abuse | 27.12 | 10.72 | 34 | 239858 | 878 | 31456574 |
Immune reconstitution inflammatory syndrome | 27.09 | 10.72 | 14 | 239878 | 8164 | 31449288 |
Neuropathy peripheral | 27.04 | 10.72 | 406 | 239486 | 75243 | 31382209 |
Oedema peripheral | 26.70 | 10.72 | 630 | 239262 | 109209 | 31348243 |
Depression | 26.42 | 10.72 | 506 | 239386 | 90309 | 31367143 |
Asthenia | 26.25 | 10.72 | 1412 | 238480 | 223343 | 31234109 |
Acute myocardial infarction | 26.11 | 10.72 | 252 | 239640 | 50571 | 31406881 |
Myocardial fibrosis | 25.60 | 10.72 | 37 | 239855 | 1099 | 31456353 |
Urine abnormality | 25.49 | 10.72 | 48 | 239844 | 1783 | 31455669 |
Blood pH decreased | 25.44 | 10.72 | 53 | 239839 | 2122 | 31455330 |
Pneumonia | 25.39 | 10.72 | 2189 | 237703 | 333123 | 31124329 |
Hyperhidrosis | 25.38 | 10.72 | 679 | 239213 | 66714 | 31390738 |
Chest discomfort | 25.24 | 10.72 | 519 | 239373 | 48850 | 31408602 |
Disease progression | 25.12 | 10.72 | 508 | 239384 | 89956 | 31367496 |
Myopathy | 25.10 | 10.72 | 27 | 239865 | 10825 | 31446627 |
Migraine | 24.73 | 10.72 | 188 | 239704 | 13992 | 31443460 |
Back pain | 24.48 | 10.72 | 1037 | 238855 | 108376 | 31349076 |
Lung neoplasm malignant | 24.46 | 10.72 | 54 | 239838 | 16176 | 31441276 |
Serum sickness | 24.43 | 10.72 | 47 | 239845 | 1775 | 31455677 |
Infusion site bruising | 24.17 | 10.72 | 25 | 239867 | 520 | 31456932 |
Product use in unapproved indication | 24.05 | 10.72 | 569 | 239323 | 98602 | 31358850 |
Hereditary angioedema | 23.67 | 10.72 | 34 | 239858 | 1004 | 31456448 |
Memory impairment | 23.64 | 10.72 | 180 | 239712 | 37950 | 31419502 |
Multiple-drug resistance | 23.63 | 10.72 | 3 | 239889 | 4477 | 31452975 |
Acute myeloid leukaemia | 23.59 | 10.72 | 68 | 239824 | 18604 | 31438848 |
Pulmonary arterial hypertension | 23.20 | 10.72 | 24 | 239868 | 9797 | 31447655 |
Vomiting | 23.19 | 10.72 | 1982 | 237910 | 221991 | 31235461 |
Hepatitis C | 22.90 | 10.72 | 28 | 239864 | 10602 | 31446850 |
Tenosynovitis | 22.81 | 10.72 | 77 | 239815 | 4133 | 31453319 |
Accidental death | 22.48 | 10.72 | 51 | 239841 | 2166 | 31455286 |
Abdominal pain | 22.44 | 10.72 | 1334 | 238558 | 144618 | 31312834 |
Monocyte percentage increased | 22.23 | 10.72 | 31 | 239861 | 890 | 31456562 |
Therapy partial responder | 22.09 | 10.72 | 11 | 239881 | 6551 | 31450901 |
Thrombocytopenia | 22.04 | 10.72 | 870 | 239022 | 141877 | 31315575 |
Enthesopathy | 22.00 | 10.72 | 77 | 239815 | 4210 | 31453242 |
Oxygen saturation abnormal | 21.87 | 10.72 | 38 | 239854 | 1325 | 31456127 |
Pulse absent | 21.35 | 10.72 | 89 | 239803 | 5288 | 31452164 |
Appendicolith | 21.32 | 10.72 | 93 | 239799 | 5638 | 31451814 |
Asthma | 21.17 | 10.72 | 213 | 239679 | 42398 | 31415054 |
Acute lung injury | 20.89 | 10.72 | 37 | 239855 | 1310 | 31456142 |
Hypertriglyceridaemia | 20.86 | 10.72 | 17 | 239875 | 7781 | 31449671 |
Mental status changes | 20.70 | 10.72 | 385 | 239507 | 35583 | 31421869 |
Visual impairment | 20.67 | 10.72 | 145 | 239747 | 31134 | 31426318 |
Syncope | 20.57 | 10.72 | 489 | 239403 | 84693 | 31372759 |
Drug level below therapeutic | 20.39 | 10.72 | 84 | 239808 | 4964 | 31452488 |
Liver injury | 20.33 | 10.72 | 173 | 239719 | 13319 | 31444133 |
Urine sodium decreased | 20.19 | 10.72 | 14 | 239878 | 163 | 31457289 |
Fluid retention | 20.02 | 10.72 | 108 | 239784 | 24694 | 31432758 |
Polyneuropathy | 19.90 | 10.72 | 43 | 239849 | 12979 | 31444473 |
Haematuria | 19.64 | 10.72 | 240 | 239652 | 46074 | 31411378 |
Therapy cessation | 19.63 | 10.72 | 54 | 239838 | 15001 | 31442451 |
Decreased appetite | 19.50 | 10.72 | 954 | 238938 | 152263 | 31305189 |
Upper respiratory tract infection | 19.46 | 10.72 | 322 | 239570 | 29100 | 31428352 |
Granulomatosis with polyangiitis | 19.26 | 10.72 | 32 | 239860 | 1075 | 31456377 |
Enterocolitis infectious | 19.13 | 10.72 | 37 | 239855 | 1403 | 31456049 |
Neutropenia | 19.04 | 10.72 | 868 | 239024 | 139496 | 31317956 |
Methaemoglobinaemia | 19.03 | 10.72 | 58 | 239834 | 2948 | 31454504 |
Deep vein thrombosis | 19.03 | 10.72 | 334 | 239558 | 60402 | 31397050 |
Erectile dysfunction | 18.91 | 10.72 | 78 | 239814 | 19157 | 31438295 |
Ejection fraction decreased | 18.88 | 10.72 | 68 | 239824 | 17366 | 31440086 |
Prostatic specific antigen increased | 18.84 | 10.72 | 47 | 239845 | 13491 | 31443961 |
Circulatory collapse | 18.84 | 10.72 | 81 | 239811 | 19663 | 31437789 |
Pulmonary congestion | 18.80 | 10.72 | 165 | 239727 | 12818 | 31444634 |
Infusion site nodule | 18.70 | 10.72 | 11 | 239881 | 94 | 31457358 |
Tooth infection | 18.66 | 10.72 | 93 | 239799 | 5961 | 31451491 |
Cardiac failure acute | 18.62 | 10.72 | 28 | 239864 | 9713 | 31447739 |
Mydriasis | 18.35 | 10.72 | 98 | 239794 | 6454 | 31450998 |
Pemphigus | 18.29 | 10.72 | 36 | 239856 | 1383 | 31456069 |
Diabetic ketoacidosis | 18.26 | 10.72 | 66 | 239826 | 16839 | 31440613 |
Blood pressure decreased | 18.24 | 10.72 | 485 | 239407 | 47606 | 31409846 |
Chronic obstructive pulmonary disease | 18.05 | 10.72 | 237 | 239655 | 44929 | 31412523 |
Swelling face | 18.01 | 10.72 | 244 | 239648 | 21146 | 31436306 |
Blood creatine phosphokinase increased | 17.99 | 10.72 | 217 | 239675 | 41757 | 31415695 |
Osteonecrosis | 17.95 | 10.72 | 50 | 239842 | 13834 | 31443618 |
Incorrect drug administration rate | 17.95 | 10.72 | 35 | 239857 | 1335 | 31456117 |
Tuberculosis | 17.94 | 10.72 | 22 | 239870 | 8319 | 31449133 |
Thrombotic microangiopathy | 17.76 | 10.72 | 27 | 239865 | 9324 | 31448128 |
Parkinsonism | 17.66 | 10.72 | 19 | 239873 | 7617 | 31449835 |
Anion gap abnormal | 17.65 | 10.72 | 12 | 239880 | 135 | 31457317 |
Stevens-Johnson syndrome | 17.55 | 10.72 | 205 | 239687 | 17167 | 31440285 |
Gastrointestinal haemorrhage | 17.50 | 10.72 | 483 | 239409 | 82066 | 31375386 |
Therapeutic product effect decreased | 17.45 | 10.72 | 154 | 239738 | 31468 | 31425984 |
Oropharyngeal pain | 17.43 | 10.72 | 335 | 239557 | 31148 | 31426304 |
Hepatic function abnormal | 17.33 | 10.72 | 214 | 239678 | 41008 | 31416444 |
Chronic gastrointestinal bleeding | 17.24 | 10.72 | 16 | 239876 | 290 | 31457162 |
Melaena | 17.16 | 10.72 | 161 | 239731 | 32493 | 31424959 |
Myelodysplastic syndrome | 17.15 | 10.72 | 81 | 239811 | 19170 | 31438282 |
Chronic graft versus host disease | 16.97 | 10.72 | 6 | 239886 | 4386 | 31453066 |
Specific gravity urine decreased | 16.95 | 10.72 | 10 | 239882 | 86 | 31457366 |
Aspergillus infection | 16.85 | 10.72 | 39 | 239853 | 11489 | 31445963 |
Alanine aminotransferase abnormal | 16.81 | 10.72 | 67 | 239825 | 3900 | 31453552 |
Rhabdomyolysis | 16.77 | 10.72 | 360 | 239532 | 63221 | 31394231 |
Renal papillary necrosis | 16.67 | 10.72 | 12 | 239880 | 149 | 31457303 |
Ischaemic stroke | 16.57 | 10.72 | 69 | 239823 | 16902 | 31440550 |
Toxic epidermal necrolysis | 16.55 | 10.72 | 223 | 239669 | 19301 | 31438151 |
Head discomfort | 16.53 | 10.72 | 64 | 239828 | 3675 | 31453777 |
Generalised bullous fixed drug eruption | 16.49 | 10.72 | 8 | 239884 | 44 | 31457408 |
Cytomegalovirus chorioretinitis | 16.47 | 10.72 | 3 | 239889 | 3425 | 31454027 |
Pulmonary embolism | 16.47 | 10.72 | 481 | 239411 | 81165 | 31376287 |
Exposure via inhalation | 16.38 | 10.72 | 7 | 239885 | 27 | 31457425 |
Agitation | 16.36 | 10.72 | 531 | 239361 | 53638 | 31403814 |
Haemolysis | 16.34 | 10.72 | 102 | 239790 | 7114 | 31450338 |
Drug screen positive | 16.28 | 10.72 | 65 | 239827 | 3787 | 31453665 |
Injection site bruising | 16.16 | 10.72 | 22 | 239870 | 7953 | 31449499 |
Drug specific antibody present | 16.06 | 10.72 | 53 | 239839 | 2812 | 31454640 |
Renal disorder | 15.92 | 10.72 | 109 | 239783 | 23536 | 31433916 |
Gynaecomastia | 15.92 | 10.72 | 28 | 239864 | 9126 | 31448326 |
Haemorrhage | 15.90 | 10.72 | 257 | 239635 | 47077 | 31410375 |
Crystal urine present | 15.80 | 10.72 | 18 | 239874 | 419 | 31457033 |
Acute graft versus host disease | 15.74 | 10.72 | 14 | 239878 | 6139 | 31451313 |
Apparent death | 15.61 | 10.72 | 4 | 239888 | 3601 | 31453851 |
Pemphigoid | 15.59 | 10.72 | 24 | 239868 | 8247 | 31449205 |
Intraocular pressure increased | 15.58 | 10.72 | 10 | 239882 | 5177 | 31452275 |
Low birth weight baby | 15.40 | 10.72 | 18 | 239874 | 6952 | 31450500 |
Specific gravity urine increased | 15.32 | 10.72 | 11 | 239881 | 136 | 31457316 |
Shock haemorrhagic | 15.22 | 10.72 | 34 | 239858 | 10143 | 31447309 |
COVID-19 | 15.19 | 10.72 | 532 | 239360 | 54289 | 31403163 |
Gastric cancer | 15.17 | 10.72 | 14 | 239878 | 6031 | 31451421 |
Hypoxia | 15.14 | 10.72 | 493 | 239399 | 49820 | 31407632 |
White blood cells urine positive | 15.14 | 10.72 | 30 | 239862 | 1158 | 31456294 |
Myalgia | 15.12 | 10.72 | 457 | 239435 | 76801 | 31380651 |
Acid-base balance disorder mixed | 15.04 | 10.72 | 8 | 239884 | 55 | 31457397 |
Red cell distribution width increased | 15.03 | 10.72 | 81 | 239811 | 5353 | 31452099 |
Full blood count abnormal | 15.03 | 10.72 | 68 | 239824 | 16279 | 31441173 |
Administration site pruritus | 14.93 | 10.72 | 6 | 239886 | 19 | 31457433 |
Pancreatitis acute | 14.87 | 10.72 | 123 | 239769 | 25477 | 31431975 |
Graft versus host disease in gastrointestinal tract | 14.79 | 10.72 | 4 | 239888 | 3475 | 31453977 |
Accidental exposure to product by child | 14.62 | 10.72 | 34 | 239858 | 1468 | 31455984 |
Anaphylactoid reaction | 14.60 | 10.72 | 42 | 239850 | 2067 | 31455385 |
Ductus arteriosus premature closure | 14.59 | 10.72 | 13 | 239879 | 223 | 31457229 |
Cerebral artery thrombosis | 14.56 | 10.72 | 23 | 239869 | 740 | 31456712 |
Product substitution issue | 14.53 | 10.72 | 31 | 239861 | 9401 | 31448051 |
Child abuse | 14.51 | 10.72 | 16 | 239876 | 359 | 31457093 |
Adverse event | 14.47 | 10.72 | 71 | 239821 | 16634 | 31440818 |
Hypocalcaemia | 14.46 | 10.72 | 102 | 239790 | 21876 | 31435576 |
Premature baby | 14.40 | 10.72 | 79 | 239813 | 17987 | 31439465 |
Product use issue | 14.31 | 10.72 | 545 | 239347 | 56214 | 31401238 |
Brain oedema | 14.12 | 10.72 | 154 | 239738 | 12678 | 31444774 |
Dysmorphism | 14.11 | 10.72 | 3 | 239889 | 3069 | 31454383 |
Coma | 13.92 | 10.72 | 409 | 239483 | 40741 | 31416711 |
Brain scan abnormal | 13.87 | 10.72 | 24 | 239868 | 834 | 31456618 |
Hypoglycaemia | 13.86 | 10.72 | 287 | 239605 | 50659 | 31406793 |
Eosinophilia | 13.84 | 10.72 | 111 | 239781 | 23142 | 31434310 |
Renal cancer | 13.80 | 10.72 | 23 | 239869 | 7656 | 31449796 |
Hepatocellular injury | 13.69 | 10.72 | 101 | 239791 | 21443 | 31436009 |
Second primary malignancy | 13.65 | 10.72 | 20 | 239872 | 7012 | 31450440 |
Self-medication | 13.62 | 10.72 | 43 | 239849 | 2228 | 31455224 |
Dizziness | 13.58 | 10.72 | 1310 | 238582 | 197837 | 31259615 |
Prescribed overdose | 13.51 | 10.72 | 31 | 239861 | 9161 | 31448291 |
Injection site extravasation | 13.50 | 10.72 | 47 | 239845 | 2563 | 31454889 |
Posterior reversible encephalopathy syndrome | 13.44 | 10.72 | 32 | 239860 | 9335 | 31448117 |
Sinus tachycardia | 13.43 | 10.72 | 181 | 239711 | 15668 | 31441784 |
Anti-erythrocyte antibody positive | 13.42 | 10.72 | 7 | 239885 | 46 | 31457406 |
Administration site erythema | 13.35 | 10.72 | 8 | 239884 | 71 | 31457381 |
Palmar-plantar erythrodysaesthesia syndrome | 13.30 | 10.72 | 66 | 239826 | 15417 | 31442035 |
Prothrombin time prolonged | 13.29 | 10.72 | 116 | 239776 | 8996 | 31448456 |
Transplant rejection | 13.28 | 10.72 | 34 | 239858 | 9674 | 31447778 |
Cytopenia | 13.25 | 10.72 | 41 | 239851 | 10969 | 31446483 |
Nocardiosis | 13.20 | 10.72 | 5 | 239887 | 3502 | 31453950 |
Skin lesion | 13.16 | 10.72 | 90 | 239802 | 19437 | 31438015 |
Injection site haemorrhage | 13.07 | 10.72 | 31 | 239861 | 9054 | 31448398 |
Croup infectious | 12.99 | 10.72 | 14 | 239878 | 306 | 31457146 |
Administration site swelling | 12.97 | 10.72 | 11 | 239881 | 176 | 31457276 |
Consciousness fluctuating | 12.91 | 10.72 | 27 | 239865 | 1084 | 31456368 |
Systemic infection | 12.84 | 10.72 | 5 | 239887 | 3444 | 31454008 |
Appendicitis | 12.81 | 10.72 | 138 | 239754 | 11327 | 31446125 |
Dyspnoea exertional | 12.67 | 10.72 | 212 | 239680 | 38625 | 31418827 |
Inappropriate antidiuretic hormone secretion | 12.60 | 10.72 | 44 | 239848 | 11343 | 31446109 |
Pain | 12.51 | 10.72 | 1605 | 238287 | 185154 | 31272298 |
Congestive cardiomyopathy | 12.47 | 10.72 | 21 | 239871 | 6961 | 31450491 |
Bronchopulmonary aspergillosis | 12.36 | 10.72 | 57 | 239835 | 13577 | 31443875 |
Rash pruritic | 12.34 | 10.72 | 252 | 239640 | 23686 | 31433766 |
Mean cell haemoglobin concentration decreased | 12.34 | 10.72 | 27 | 239865 | 1119 | 31456333 |
Acidosis | 12.19 | 10.72 | 122 | 239770 | 9824 | 31447628 |
Bilirubin urine present | 12.16 | 10.72 | 10 | 239882 | 153 | 31457299 |
Chronic kidney disease | 12.16 | 10.72 | 208 | 239684 | 37767 | 31419685 |
Fixed eruption | 12.13 | 10.72 | 31 | 239861 | 1422 | 31456030 |
Bacterial test | 12.11 | 10.72 | 10 | 239882 | 154 | 31457298 |
Mucosal erosion | 12.11 | 10.72 | 22 | 239870 | 795 | 31456657 |
Blood glucose increased | 12.03 | 10.72 | 361 | 239531 | 60722 | 31396730 |
Kidney transplant rejection | 12.02 | 10.72 | 23 | 239869 | 7259 | 31450193 |
Eosinophil percentage increased | 12.01 | 10.72 | 17 | 239875 | 495 | 31456957 |
Ultrasound liver abnormal | 11.97 | 10.72 | 9 | 239883 | 120 | 31457332 |
Febrile bone marrow aplasia | 11.91 | 10.72 | 26 | 239866 | 7820 | 31449632 |
Cardiac disorder | 11.85 | 10.72 | 217 | 239675 | 38997 | 31418455 |
Dependent personality disorder | 11.84 | 10.72 | 8 | 239884 | 89 | 31457363 |
Depressed mood | 11.84 | 10.72 | 81 | 239811 | 17494 | 31439958 |
Antineutrophil cytoplasmic antibody positive | 11.84 | 10.72 | 19 | 239873 | 620 | 31456832 |
Inadequate analgesia | 11.83 | 10.72 | 46 | 239846 | 2647 | 31454805 |
Pupil fixed | 11.82 | 10.72 | 34 | 239858 | 1673 | 31455779 |
Adenocarcinoma of colon | 11.81 | 10.72 | 5 | 239887 | 3275 | 31454177 |
Hepatic cirrhosis | 11.71 | 10.72 | 70 | 239822 | 15604 | 31441848 |
Ear infection viral | 11.67 | 10.72 | 3 | 239889 | 0 | 31457452 |
Electrocardiogram QRS complex prolonged | 11.67 | 10.72 | 63 | 239829 | 4166 | 31453286 |
Infusion site urticaria | 11.66 | 10.72 | 9 | 239883 | 125 | 31457327 |
Diffuse large B-cell lymphoma recurrent | 11.61 | 10.72 | 4 | 239888 | 2971 | 31454481 |
Angioedema | 11.60 | 10.72 | 335 | 239557 | 33283 | 31424169 |
Subdural haematoma | 11.55 | 10.72 | 90 | 239802 | 18881 | 31438571 |
Bacterial test positive | 11.52 | 10.72 | 49 | 239843 | 2937 | 31454515 |
Neoplasm progression | 11.50 | 10.72 | 98 | 239794 | 20174 | 31437278 |
Pulmonary alveolar haemorrhage | 11.49 | 10.72 | 21 | 239871 | 6745 | 31450707 |
Urine analysis abnormal | 11.45 | 10.72 | 36 | 239856 | 1861 | 31455591 |
Infusion site irritation | 11.43 | 10.72 | 11 | 239881 | 209 | 31457243 |
BK virus infection | 11.43 | 10.72 | 13 | 239879 | 5082 | 31452370 |
Immune effector cell-associated neurotoxicity syndrome | 11.43 | 10.72 | 43 | 239849 | 2436 | 31455016 |
Haematocrit decreased | 11.34 | 10.72 | 303 | 239589 | 29758 | 31427694 |
Balance disorder | 11.34 | 10.72 | 207 | 239685 | 37215 | 31420237 |
Right ventricular failure | 11.33 | 10.72 | 29 | 239863 | 8253 | 31449199 |
Post embolisation syndrome | 11.33 | 10.72 | 7 | 239885 | 66 | 31457386 |
Dermatitis exfoliative generalised | 11.33 | 10.72 | 5 | 239887 | 3194 | 31454258 |
Trichoglossia | 11.29 | 10.72 | 12 | 239880 | 258 | 31457194 |
Rash erythematous | 11.27 | 10.72 | 237 | 239655 | 22390 | 31435062 |
Angina unstable | 11.26 | 10.72 | 45 | 239847 | 11150 | 31446302 |
Infusion site haemorrhage | 11.25 | 10.72 | 22 | 239870 | 841 | 31456611 |
Ischaemic cardiomyopathy | 11.22 | 10.72 | 17 | 239875 | 5880 | 31451572 |
Somnolence | 11.21 | 10.72 | 886 | 239006 | 98559 | 31358893 |
Acute graft versus host disease in skin | 11.20 | 10.72 | 12 | 239880 | 4820 | 31452632 |
Lactic acidosis | 11.20 | 10.72 | 172 | 239720 | 31765 | 31425687 |
Protein urine | 11.20 | 10.72 | 22 | 239870 | 844 | 31456608 |
Administration site pain | 11.18 | 10.72 | 11 | 239881 | 215 | 31457237 |
Gait inability | 11.11 | 10.72 | 92 | 239800 | 19052 | 31438400 |
Sleep disorder due to a general medical condition | 11.08 | 10.72 | 8 | 239884 | 3894 | 31453558 |
Leukoencephalopathy | 11.08 | 10.72 | 8 | 239884 | 3894 | 31453558 |
COVID-19 immunisation | 10.90 | 10.72 | 11 | 239881 | 222 | 31457230 |
Venoocclusive liver disease | 10.89 | 10.72 | 25 | 239867 | 7387 | 31450065 |
Transplant failure | 10.89 | 10.72 | 5 | 239887 | 3121 | 31454331 |
Hypoxic-ischaemic encephalopathy | 10.87 | 10.72 | 63 | 239829 | 4278 | 31453174 |
Obstructive airways disorder | 10.87 | 10.72 | 54 | 239838 | 12610 | 31444842 |
Oral pruritus | 10.86 | 10.72 | 12 | 239880 | 270 | 31457182 |
Febrile nonhaemolytic transfusion reaction | 10.85 | 10.72 | 6 | 239886 | 45 | 31457407 |
Disturbance in attention | 10.83 | 10.72 | 113 | 239779 | 22337 | 31435115 |
Urethral valves | 10.82 | 10.72 | 12 | 239880 | 271 | 31457181 |
Osteoporosis | 10.76 | 10.72 | 48 | 239844 | 11535 | 31445917 |
Gait disturbance | 10.74 | 10.72 | 478 | 239414 | 77017 | 31380435 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 4970.07 | 10.32 | 8235 | 666634 | 218900 | 70034675 |
Toxicity to various agents | 4064.25 | 10.32 | 10272 | 664597 | 371900 | 69881675 |
Infusion related reaction | 1858.21 | 10.32 | 5080 | 669789 | 192454 | 70061121 |
Intentional product misuse | 851.09 | 10.32 | 2149 | 672720 | 77446 | 70176129 |
Drug abuse | 806.13 | 10.32 | 3151 | 671718 | 144105 | 70109470 |
Blood pressure fluctuation | 805.32 | 10.32 | 1753 | 673116 | 57259 | 70196316 |
Overdose | 731.27 | 10.32 | 3377 | 671492 | 166368 | 70087207 |
Urticaria | 637.14 | 10.32 | 3154 | 671715 | 159895 | 70093680 |
Exposure to toxic agent | 632.45 | 10.32 | 502 | 674367 | 5692 | 70247883 |
Acute hepatic failure | 527.55 | 10.32 | 946 | 673923 | 26726 | 70226849 |
Intentional overdose | 517.95 | 10.32 | 2081 | 672788 | 96354 | 70157221 |
Flushing | 481.93 | 10.32 | 1798 | 673071 | 80374 | 70173201 |
Respiratory arrest | 469.50 | 10.32 | 1350 | 673519 | 52583 | 70200992 |
Blood pressure increased | 393.80 | 10.32 | 3105 | 671764 | 185412 | 70068163 |
Cardio-respiratory arrest | 384.83 | 10.32 | 1936 | 672933 | 98741 | 70154834 |
Pruritus | 373.04 | 10.32 | 4969 | 669900 | 340591 | 69912984 |
Anaemia | 363.80 | 10.32 | 2297 | 672572 | 401126 | 69852449 |
Drug interaction | 362.67 | 10.32 | 2136 | 672733 | 379305 | 69874270 |
Heart rate decreased | 324.45 | 10.32 | 1309 | 673560 | 60706 | 70192869 |
Acute kidney injury | 320.70 | 10.32 | 2929 | 671940 | 471695 | 69781880 |
Cardiac failure | 313.28 | 10.32 | 553 | 674316 | 142988 | 70110587 |
Oxygen saturation decreased | 288.75 | 10.32 | 1998 | 672871 | 114431 | 70139144 |
Heart rate increased | 278.41 | 10.32 | 1847 | 673022 | 104301 | 70149274 |
Throat irritation | 275.24 | 10.32 | 850 | 674019 | 34454 | 70219121 |
Product dose omission issue | 273.58 | 10.32 | 1102 | 673767 | 216366 | 70037209 |
Blood pressure diastolic abnormal | 269.01 | 10.32 | 509 | 674360 | 14995 | 70238580 |
Exposure via ingestion | 267.91 | 10.32 | 280 | 674589 | 4635 | 70248940 |
Blood pressure systolic increased | 267.83 | 10.32 | 1168 | 673701 | 56091 | 70197484 |
Anion gap | 254.36 | 10.32 | 180 | 674689 | 1690 | 70251885 |
Sinusitis | 253.58 | 10.32 | 2593 | 672276 | 166602 | 70086973 |
Cardiac failure congestive | 253.37 | 10.32 | 571 | 674298 | 134886 | 70118689 |
Intentional product use issue | 246.93 | 10.32 | 1972 | 672897 | 118170 | 70135405 |
Myocardial infarction | 233.15 | 10.32 | 843 | 674026 | 170802 | 70082773 |
Diarrhoea | 232.65 | 10.32 | 5679 | 669190 | 777662 | 69475913 |
Drug resistance | 228.67 | 10.32 | 43 | 674826 | 38147 | 70215428 |
Poisoning | 227.38 | 10.32 | 597 | 674272 | 22025 | 70231550 |
Psoriasis | 225.05 | 10.32 | 368 | 674501 | 98065 | 70155510 |
Renal impairment | 213.09 | 10.32 | 681 | 674188 | 143256 | 70110319 |
Blood pressure systolic abnormal | 208.30 | 10.32 | 411 | 674458 | 12498 | 70241077 |
Injection site pain | 202.36 | 10.32 | 518 | 674351 | 117101 | 70136474 |
Metabolic acidosis | 198.14 | 10.32 | 1299 | 673570 | 73047 | 70180528 |
Hypersensitivity | 192.00 | 10.32 | 3163 | 671706 | 226649 | 70026926 |
Neutropenia | 186.13 | 10.32 | 1558 | 673311 | 255598 | 69997977 |
Muscle injury | 185.97 | 10.32 | 793 | 674076 | 37701 | 70215874 |
Interstitial lung disease | 183.99 | 10.32 | 456 | 674413 | 104229 | 70149346 |
Drug ineffective | 179.31 | 10.32 | 7222 | 667647 | 932530 | 69321045 |
Urine abnormality | 173.04 | 10.32 | 286 | 674583 | 7552 | 70246023 |
Hepatotoxicity | 170.19 | 10.32 | 849 | 674020 | 43137 | 70210438 |
Folliculitis | 166.36 | 10.32 | 824 | 674045 | 41746 | 70211829 |
Irritable bowel syndrome | 166.30 | 10.32 | 937 | 673932 | 49913 | 70203662 |
Sopor | 165.67 | 10.32 | 46 | 674823 | 31221 | 70222354 |
Pancytopenia | 165.57 | 10.32 | 806 | 674063 | 150301 | 70103274 |
Body temperature increased | 163.53 | 10.32 | 782 | 674087 | 39052 | 70214523 |
Medication error | 159.39 | 10.32 | 1007 | 673862 | 55905 | 70197670 |
Nasopharyngitis | 159.00 | 10.32 | 2984 | 671885 | 219222 | 70034353 |
Duodenal ulcer perforation | 158.75 | 10.32 | 929 | 673940 | 50183 | 70203392 |
Osteonecrosis of jaw | 158.19 | 10.32 | 97 | 674772 | 40905 | 70212670 |
Blood pressure diastolic decreased | 155.15 | 10.32 | 569 | 674300 | 25211 | 70228364 |
Pneumonia | 154.07 | 10.32 | 4408 | 670461 | 591824 | 69661751 |
Analgesic drug level increased | 152.94 | 10.32 | 150 | 674719 | 2293 | 70251282 |
Hepatic cytolysis | 147.65 | 10.32 | 460 | 674409 | 18732 | 70234843 |
Helicobacter infection | 147.41 | 10.32 | 971 | 673898 | 54685 | 70198890 |
Hyperkalaemia | 147.00 | 10.32 | 520 | 674349 | 106071 | 70147504 |
Malignant neoplasm progression | 146.69 | 10.32 | 627 | 674242 | 121112 | 70132463 |
Sleep disorder due to general medical condition, insomnia type | 146.33 | 10.32 | 701 | 674168 | 35031 | 70218544 |
Synovitis | 145.18 | 10.32 | 1873 | 672996 | 127355 | 70126220 |
Throat tightness | 144.51 | 10.32 | 545 | 674324 | 24477 | 70229098 |
Respiratory depression | 142.71 | 10.32 | 540 | 674329 | 24291 | 70229284 |
Accidental overdose | 142.37 | 10.32 | 687 | 674182 | 34434 | 70219141 |
Wrong technique in product usage process | 140.66 | 10.32 | 275 | 674594 | 68423 | 70185152 |
Suspected suicide | 137.42 | 10.32 | 277 | 674592 | 8557 | 70245018 |
Chills | 136.88 | 10.32 | 2035 | 672834 | 142751 | 70110824 |
Device expulsion | 135.45 | 10.32 | 24 | 674845 | 22222 | 70231353 |
Heart rate irregular | 134.72 | 10.32 | 601 | 674268 | 29142 | 70224433 |
Bone marrow failure | 132.06 | 10.32 | 163 | 674706 | 48847 | 70204728 |
Urine leukocyte esterase positive | 127.05 | 10.32 | 165 | 674704 | 3480 | 70250095 |
Thrombocytopenia | 126.45 | 10.32 | 1561 | 673308 | 237549 | 70016026 |
Renal failure | 126.35 | 10.32 | 1169 | 673700 | 187901 | 70065674 |
Impaired healing | 124.59 | 10.32 | 1167 | 673702 | 73207 | 70180368 |
Pain | 121.96 | 10.32 | 7225 | 667644 | 621591 | 69631984 |
Plasma cell myeloma | 121.60 | 10.32 | 328 | 674541 | 72873 | 70180702 |
Hepatic necrosis | 119.19 | 10.32 | 258 | 674611 | 8388 | 70245187 |
Anti-cyclic citrullinated peptide antibody positive | 118.43 | 10.32 | 1103 | 673766 | 69082 | 70184493 |
Disease progression | 116.09 | 10.32 | 943 | 673926 | 155729 | 70097846 |
Hepatic enzyme increased | 115.97 | 10.32 | 2119 | 672750 | 154871 | 70098704 |
Septic shock | 114.32 | 10.32 | 614 | 674255 | 111644 | 70141931 |
Discomfort | 113.32 | 10.32 | 1516 | 673353 | 103920 | 70149655 |
Ill-defined disorder | 112.65 | 10.32 | 899 | 673970 | 53842 | 70199733 |
Cardiac arrest | 112.39 | 10.32 | 2141 | 672728 | 157693 | 70095882 |
Coagulopathy | 110.25 | 10.32 | 615 | 674254 | 32634 | 70220941 |
Weight increased | 108.52 | 10.32 | 3047 | 671822 | 239284 | 70014291 |
Suicide attempt | 107.98 | 10.32 | 1195 | 673674 | 78315 | 70175260 |
Lower respiratory tract infection | 107.33 | 10.32 | 1577 | 673292 | 110336 | 70143239 |
Rash | 107.13 | 10.32 | 5909 | 668960 | 504653 | 69748922 |
Cerebrovascular accident | 107.00 | 10.32 | 862 | 674007 | 142608 | 70110967 |
Hand deformity | 106.79 | 10.32 | 1276 | 673593 | 85206 | 70168369 |
Anaphylactic reaction | 106.52 | 10.32 | 1137 | 673732 | 73837 | 70179738 |
Blister | 104.99 | 10.32 | 1438 | 673431 | 99088 | 70154487 |
Blood pressure diastolic increased | 104.73 | 10.32 | 307 | 674562 | 12084 | 70241491 |
Cerebral haemorrhage | 104 | 10.32 | 223 | 674646 | 53641 | 70199934 |
Food allergy | 103.68 | 10.32 | 242 | 674627 | 8282 | 70245293 |
White blood cells urine positive | 102.63 | 10.32 | 189 | 674680 | 5451 | 70248124 |
Oedema peripheral | 101.89 | 10.32 | 1541 | 673328 | 226550 | 70027025 |
Atrial fibrillation | 101.82 | 10.32 | 1192 | 673677 | 183156 | 70070419 |
Depressed level of consciousness | 100.18 | 10.32 | 1272 | 673597 | 86159 | 70167416 |
Erythema | 99.86 | 10.32 | 2546 | 672323 | 197017 | 70056558 |
Arthropathy | 99.40 | 10.32 | 1992 | 672877 | 148065 | 70105510 |
Epilepsy | 99.32 | 10.32 | 134 | 674735 | 38650 | 70214925 |
Poor venous access | 99.14 | 10.32 | 341 | 674528 | 14630 | 70238945 |
Therapeutic product effect incomplete | 99.00 | 10.32 | 700 | 674169 | 119182 | 70134393 |
General physical health deterioration | 98.58 | 10.32 | 1615 | 673254 | 234416 | 70019159 |
Feeling hot | 97.27 | 10.32 | 794 | 674075 | 47876 | 70205699 |
Leukopenia | 97.16 | 10.32 | 604 | 674265 | 105956 | 70147619 |
Injection site bruising | 96.79 | 10.32 | 132 | 674737 | 37900 | 70215675 |
Cytomegalovirus infection | 95.25 | 10.32 | 144 | 674725 | 39614 | 70213961 |
Pericarditis | 93.54 | 10.32 | 1224 | 673645 | 83481 | 70170094 |
Pulmonary arterial hypertension | 93.09 | 10.32 | 105 | 674764 | 32750 | 70220825 |
Crystal urine present | 92.44 | 10.32 | 106 | 674763 | 1956 | 70251619 |
Hereditary angioedema | 91.39 | 10.32 | 169 | 674700 | 4890 | 70248685 |
Therapy cessation | 90.73 | 10.32 | 112 | 674757 | 33564 | 70220011 |
Injection site erythema | 90.66 | 10.32 | 371 | 674498 | 72553 | 70181022 |
Sedation complication | 90.16 | 10.32 | 307 | 674562 | 13103 | 70240472 |
Chest discomfort | 90.14 | 10.32 | 1674 | 673195 | 122707 | 70130868 |
Diabetes mellitus | 89.55 | 10.32 | 365 | 674504 | 71459 | 70182116 |
Hospitalisation | 89.48 | 10.32 | 442 | 674427 | 82126 | 70171449 |
Coronary artery disease | 89.22 | 10.32 | 302 | 674567 | 62434 | 70191141 |
Pemphigus | 88.83 | 10.32 | 1193 | 673676 | 81843 | 70171732 |
Respiratory rate increased | 88.71 | 10.32 | 397 | 674472 | 19275 | 70234300 |
Hyponatraemia | 87.28 | 10.32 | 1038 | 673831 | 159049 | 70094526 |
Infusion site pain | 86.96 | 10.32 | 275 | 674594 | 11289 | 70242286 |
Tachycardia | 86.88 | 10.32 | 2048 | 672821 | 156498 | 70097077 |
Prostate cancer | 86.77 | 10.32 | 101 | 674768 | 31062 | 70222513 |
Lymphocyte count decreased | 86.31 | 10.32 | 709 | 674160 | 42830 | 70210745 |
Gastrointestinal haemorrhage | 86.08 | 10.32 | 863 | 674006 | 136545 | 70117030 |
Cerebral infarction | 85.61 | 10.32 | 175 | 674694 | 42834 | 70210741 |
Lymphocyte percentage decreased | 85.52 | 10.32 | 159 | 674710 | 4620 | 70248955 |
Product use in unapproved indication | 84.21 | 10.32 | 1427 | 673442 | 206051 | 70047524 |
Pyroglutamic acidosis | 83.66 | 10.32 | 67 | 674802 | 770 | 70252805 |
Neuropathy peripheral | 82.84 | 10.32 | 789 | 674080 | 126107 | 70127468 |
Body temperature decreased | 82.55 | 10.32 | 511 | 674358 | 28161 | 70225414 |
Infusion site extravasation | 82.17 | 10.32 | 213 | 674656 | 7795 | 70245780 |
Posterior reversible encephalopathy syndrome | 81.93 | 10.32 | 67 | 674802 | 24335 | 70229240 |
Neoplasm progression | 81.02 | 10.32 | 195 | 674674 | 45033 | 70208542 |
Lactic acidosis | 80.09 | 10.32 | 332 | 674537 | 64692 | 70188883 |
Neutrophil percentage increased | 79.89 | 10.32 | 150 | 674719 | 4392 | 70249183 |
Syncope | 79.05 | 10.32 | 1105 | 673764 | 164604 | 70088971 |
Fall | 78.46 | 10.32 | 3440 | 671429 | 440656 | 69812919 |
Decreased appetite | 78.27 | 10.32 | 2254 | 672615 | 302526 | 69951049 |
Labelled drug-drug interaction medication error | 77.64 | 10.32 | 69 | 674800 | 24058 | 70229517 |
Therapeutic response shortened | 76.94 | 10.32 | 283 | 674586 | 12555 | 70241020 |
Urinary sediment present | 76.80 | 10.32 | 103 | 674766 | 2244 | 70251331 |
Anticholinergic syndrome | 75.78 | 10.32 | 116 | 674753 | 2864 | 70250711 |
Infusion site swelling | 75.42 | 10.32 | 176 | 674693 | 6022 | 70247553 |
Myelosuppression | 75.33 | 10.32 | 106 | 674763 | 30039 | 70223536 |
Temperature regulation disorder | 74.75 | 10.32 | 144 | 674725 | 4300 | 70249275 |
Body temperature fluctuation | 74.75 | 10.32 | 127 | 674742 | 3432 | 70250143 |
Haematotoxicity | 74.56 | 10.32 | 19 | 674850 | 13655 | 70239920 |
Unresponsive to stimuli | 74.43 | 10.32 | 789 | 674080 | 51142 | 70202433 |
Arthralgia | 73.57 | 10.32 | 5650 | 669219 | 497740 | 69755835 |
Wound | 73.34 | 10.32 | 1334 | 673535 | 97398 | 70156177 |
Pathogen resistance | 73.28 | 10.32 | 18 | 674851 | 13261 | 70240314 |
Sepsis | 72.63 | 10.32 | 1771 | 673098 | 242774 | 70010801 |
Acute lung injury | 72.36 | 10.32 | 110 | 674759 | 2699 | 70250876 |
Glossodynia | 71.96 | 10.32 | 1190 | 673679 | 85297 | 70168278 |
Cytokine release syndrome | 71.43 | 10.32 | 464 | 674405 | 26003 | 70227572 |
Myelodysplastic syndrome | 71.23 | 10.32 | 108 | 674761 | 29677 | 70223898 |
Inappropriate schedule of product administration | 70.60 | 10.32 | 1426 | 673443 | 106129 | 70147446 |
Ear pruritus | 70.45 | 10.32 | 114 | 674755 | 2956 | 70250619 |
Swelling | 70.24 | 10.32 | 2318 | 672551 | 186221 | 70067354 |
Infusion site erythema | 69.83 | 10.32 | 193 | 674676 | 7342 | 70246233 |
Diabetic ketoacidosis | 68.15 | 10.32 | 122 | 674747 | 31390 | 70222185 |
Creatinine renal clearance decreased | 67.95 | 10.32 | 334 | 674535 | 16866 | 70236709 |
Acute myocardial infarction | 67.54 | 10.32 | 411 | 674458 | 72476 | 70181099 |
Post transplant lymphoproliferative disorder | 67.28 | 10.32 | 10 | 674859 | 10535 | 70243040 |
Red cell distribution width increased | 67.23 | 10.32 | 283 | 674586 | 13374 | 70240201 |
Acute myeloid leukaemia | 66.72 | 10.32 | 120 | 674749 | 30820 | 70222755 |
Visual acuity reduced | 65.14 | 10.32 | 103 | 674766 | 27827 | 70225748 |
Product prescribing error | 65.08 | 10.32 | 174 | 674695 | 38778 | 70214797 |
Blood calcium decreased | 63.92 | 10.32 | 482 | 674387 | 28364 | 70225211 |
Haematuria | 63.45 | 10.32 | 350 | 674519 | 63223 | 70190352 |
Agranulocytosis | 62.90 | 10.32 | 186 | 674683 | 40112 | 70213463 |
Respiratory failure | 62.59 | 10.32 | 1179 | 673690 | 167556 | 70086019 |
Infusion site pruritus | 62.11 | 10.32 | 111 | 674758 | 3126 | 70250449 |
Hypocalcaemia | 61.05 | 10.32 | 220 | 674649 | 44639 | 70208936 |
Rhabdomyolysis | 60.55 | 10.32 | 600 | 674269 | 95160 | 70158415 |
Graft versus host disease | 60.12 | 10.32 | 34 | 674835 | 14989 | 70238586 |
Cardiac failure acute | 59.98 | 10.32 | 47 | 674822 | 17440 | 70236135 |
Dyspnoea exertional | 59.94 | 10.32 | 468 | 674401 | 77962 | 70175613 |
Substance abuse | 59.08 | 10.32 | 217 | 674652 | 9620 | 70243955 |
Red blood cells urine positive | 58.71 | 10.32 | 135 | 674734 | 4574 | 70249001 |
Immune reconstitution inflammatory syndrome | 58.65 | 10.32 | 25 | 674844 | 12965 | 70240610 |
Bladder cancer | 58.31 | 10.32 | 47 | 674822 | 17195 | 70236380 |
Dehydration | 58.13 | 10.32 | 1672 | 673197 | 224470 | 70029105 |
Pulmonary hypertension | 57.68 | 10.32 | 237 | 674632 | 46299 | 70207276 |
Oesophageal carcinoma | 57.25 | 10.32 | 10 | 674859 | 9356 | 70244219 |
Liver injury | 57.20 | 10.32 | 620 | 674249 | 40415 | 70213160 |
Product substitution issue | 57.14 | 10.32 | 55 | 674814 | 18458 | 70235117 |
Contraindicated product administered | 56.17 | 10.32 | 1678 | 673191 | 132934 | 70120641 |
Environmental exposure | 55.92 | 10.32 | 38 | 674831 | 332 | 70253243 |
Multiple organ dysfunction syndrome | 55.21 | 10.32 | 714 | 674155 | 107801 | 70145774 |
Alanine aminotransferase increased | 54.34 | 10.32 | 1811 | 673058 | 145669 | 70107906 |
Pharyngeal paraesthesia | 54.13 | 10.32 | 85 | 674784 | 2147 | 70251428 |
Cholecystitis chronic | 53.95 | 10.32 | 204 | 674665 | 9172 | 70244403 |
Pneumocystis jirovecii pneumonia | 53.64 | 10.32 | 130 | 674739 | 29952 | 70223623 |
Gastrointestinal disorder | 53.55 | 10.32 | 1348 | 673521 | 104079 | 70149496 |
Joint swelling | 53.41 | 10.32 | 2933 | 671936 | 250278 | 70003297 |
Lung neoplasm malignant | 53.32 | 10.32 | 96 | 674773 | 24646 | 70228929 |
Headache | 53.19 | 10.32 | 6303 | 668566 | 574102 | 69679473 |
Tongue disorder | 53.07 | 10.32 | 258 | 674611 | 12969 | 70240606 |
Second primary malignancy | 53.01 | 10.32 | 29 | 674840 | 13022 | 70240553 |
Aspergillus infection | 52.95 | 10.32 | 55 | 674814 | 17813 | 70235762 |
Cardiac failure chronic | 52.76 | 10.32 | 16 | 674853 | 10253 | 70243322 |
Systemic lupus erythematosus | 51.78 | 10.32 | 1303 | 673566 | 100599 | 70152976 |
Chronic kidney disease | 51.63 | 10.32 | 354 | 674515 | 60703 | 70192872 |
Poisoning deliberate | 51.62 | 10.32 | 308 | 674561 | 16752 | 70236823 |
Anion gap abnormal | 51.38 | 10.32 | 42 | 674827 | 498 | 70253077 |
Inappropriate antidiuretic hormone secretion | 51.34 | 10.32 | 89 | 674780 | 23187 | 70230388 |
Melaena | 51.06 | 10.32 | 320 | 674549 | 56035 | 70197540 |
Injury | 50.73 | 10.32 | 888 | 673981 | 64357 | 70189218 |
Hypotension | 50.56 | 10.32 | 4486 | 670383 | 399895 | 69853680 |
Transplant rejection | 50.47 | 10.32 | 59 | 674810 | 18112 | 70235463 |
Osteonecrosis | 50.45 | 10.32 | 128 | 674741 | 29032 | 70224543 |
Asthenia | 50.24 | 10.32 | 3712 | 671157 | 453954 | 69799621 |
Death | 50.07 | 10.32 | 5564 | 669305 | 504497 | 69749078 |
Hepatocellular injury | 49.78 | 10.32 | 247 | 674622 | 45844 | 70207731 |
Ischaemic stroke | 49.75 | 10.32 | 140 | 674729 | 30680 | 70222895 |
Blood urine present | 49.63 | 10.32 | 335 | 674534 | 19018 | 70234557 |
Thrombotic microangiopathy | 49.52 | 10.32 | 58 | 674811 | 17790 | 70235785 |
Hypokalaemia | 49.46 | 10.32 | 914 | 673955 | 130274 | 70123301 |
Multiple-drug resistance | 49.25 | 10.32 | 6 | 674863 | 7349 | 70246226 |
Urine ketone body present | 49.08 | 10.32 | 103 | 674766 | 3276 | 70250299 |
Polyneuropathy | 48.98 | 10.32 | 80 | 674789 | 21335 | 70232240 |
Haemorrhage | 48.57 | 10.32 | 536 | 674333 | 83279 | 70170296 |
Full blood count abnormal | 48.22 | 10.32 | 163 | 674706 | 33715 | 70219860 |
Therapeutic product effect decreased | 47.89 | 10.32 | 1737 | 673132 | 141281 | 70112294 |
Endophthalmitis | 47.56 | 10.32 | 3 | 674866 | 6252 | 70247323 |
Product storage error | 47.50 | 10.32 | 41 | 674828 | 14500 | 70239075 |
Subdural haematoma | 47.36 | 10.32 | 133 | 674736 | 29165 | 70224410 |
Acute graft versus host disease | 47.18 | 10.32 | 16 | 674853 | 9546 | 70244029 |
Palmar-plantar erythrodysaesthesia syndrome | 46.93 | 10.32 | 140 | 674729 | 30107 | 70223468 |
Urine analysis abnormal | 46.87 | 10.32 | 147 | 674722 | 6007 | 70247568 |
Bronchopulmonary aspergillosis | 46.61 | 10.32 | 80 | 674789 | 20922 | 70232653 |
Mucosal inflammation | 46.36 | 10.32 | 417 | 674452 | 67433 | 70186142 |
Breast cancer stage I | 46.17 | 10.32 | 3 | 674866 | 6099 | 70247476 |
Ear pain | 46.17 | 10.32 | 433 | 674436 | 27166 | 70226409 |
Specific gravity urine decreased | 46.00 | 10.32 | 48 | 674821 | 793 | 70252782 |
Epistaxis | 45.89 | 10.32 | 693 | 674176 | 101934 | 70151641 |
Mydriasis | 45.32 | 10.32 | 286 | 674583 | 15867 | 70237708 |
Accidental death | 44.34 | 10.32 | 108 | 674761 | 3800 | 70249775 |
Hepatic function abnormal | 44.26 | 10.32 | 423 | 674446 | 67573 | 70186002 |
Aspartate aminotransferase increased | 44.19 | 10.32 | 1549 | 673320 | 125429 | 70128146 |
Right ventricular failure | 44.01 | 10.32 | 91 | 674778 | 22183 | 70231392 |
Hepatocellular carcinoma | 43.97 | 10.32 | 21 | 674848 | 10187 | 70243388 |
Blood pH decreased | 43.83 | 10.32 | 117 | 674752 | 4359 | 70249216 |
Angina pectoris | 43.18 | 10.32 | 276 | 674593 | 48107 | 70205468 |
Device malfunction | 42.99 | 10.32 | 72 | 674797 | 19012 | 70234563 |
Gait disturbance | 42.55 | 10.32 | 1389 | 673480 | 183717 | 70069858 |
Peripheral swelling | 42.43 | 10.32 | 2701 | 672168 | 233862 | 70019713 |
Bursitis | 42.41 | 10.32 | 414 | 674455 | 26259 | 70227316 |
Hypertensive crisis | 42.17 | 10.32 | 74 | 674795 | 19188 | 70234387 |
Myopathy | 42.13 | 10.32 | 70 | 674799 | 18542 | 70235033 |
Colorectal cancer | 42.09 | 10.32 | 14 | 674855 | 8456 | 70245119 |
Hepatic cirrhosis | 41.63 | 10.32 | 151 | 674718 | 30580 | 70222995 |
Pyroglutamate increased | 41.58 | 10.32 | 41 | 674828 | 631 | 70252944 |
Cognitive disorder | 41.26 | 10.32 | 812 | 674057 | 60144 | 70193431 |
Systemic infection | 40.92 | 10.32 | 7 | 674862 | 6650 | 70246925 |
Hypoglycaemia | 40.90 | 10.32 | 641 | 674228 | 93723 | 70159852 |
Injection site haemorrhage | 40.44 | 10.32 | 117 | 674752 | 25410 | 70228165 |
Memory impairment | 40.25 | 10.32 | 629 | 674240 | 92012 | 70161563 |
Breast cancer female | 40.18 | 10.32 | 25 | 674844 | 10461 | 70243114 |
Febrile bone marrow aplasia | 40.16 | 10.32 | 33 | 674836 | 11958 | 70241617 |
Rash erythematous | 39.88 | 10.32 | 703 | 674166 | 51015 | 70202560 |
Postmortem blood drug level increased | 39.83 | 10.32 | 43 | 674826 | 740 | 70252835 |
Therapy interrupted | 39.79 | 10.32 | 113 | 674756 | 24689 | 70228886 |
Chronic obstructive pulmonary disease | 39.44 | 10.32 | 511 | 674358 | 77130 | 70176445 |
Monocyte percentage increased | 39.08 | 10.32 | 70 | 674799 | 1975 | 70251600 |
Bacterial test | 38.99 | 10.32 | 53 | 674816 | 1170 | 70252405 |
Platelet count decreased | 38.93 | 10.32 | 1346 | 673523 | 176876 | 70076699 |
Injection site swelling | 38.61 | 10.32 | 246 | 674623 | 42911 | 70210664 |
Toxic skin eruption | 38.48 | 10.32 | 84 | 674785 | 20078 | 70233497 |
Transient ischaemic attack | 38.04 | 10.32 | 268 | 674601 | 45676 | 70207899 |
Altered state of consciousness | 37.96 | 10.32 | 224 | 674645 | 39798 | 70213777 |
Chronic graft versus host disease | 37.70 | 10.32 | 9 | 674860 | 6761 | 70246814 |
Bacterial test positive | 37.22 | 10.32 | 149 | 674720 | 6882 | 70246693 |
Infusion site bruising | 37.07 | 10.32 | 67 | 674802 | 1904 | 70251671 |
Glycosylated haemoglobin increased | 37.01 | 10.32 | 68 | 674801 | 17323 | 70236252 |
Renal disorder | 36.98 | 10.32 | 211 | 674658 | 37798 | 70215777 |
Electric shock | 36.91 | 10.32 | 51 | 674818 | 1144 | 70252431 |
Transplant dysfunction | 36.91 | 10.32 | 10 | 674859 | 6899 | 70246676 |
Specific gravity urine increased | 36.90 | 10.32 | 32 | 674837 | 414 | 70253161 |
Ascites | 36.77 | 10.32 | 438 | 674431 | 67109 | 70186466 |
Serum sickness | 36.50 | 10.32 | 91 | 674778 | 3250 | 70250325 |
Drug hypersensitivity | 36.12 | 10.32 | 2933 | 671936 | 259526 | 69994049 |
Sedation | 35.96 | 10.32 | 635 | 674234 | 46096 | 70207479 |
Immunodeficiency | 35.94 | 10.32 | 288 | 674581 | 17267 | 70236308 |
Product monitoring error | 35.84 | 10.32 | 10 | 674859 | 6766 | 70246809 |
Culture urine positive | 35.83 | 10.32 | 105 | 674764 | 4132 | 70249443 |
Neurotoxicity | 35.66 | 10.32 | 154 | 674715 | 29672 | 70223903 |
Drug level below therapeutic | 35.61 | 10.32 | 171 | 674698 | 8552 | 70245023 |
Abortion spontaneous | 35.28 | 10.32 | 131 | 674738 | 26348 | 70227227 |
Drug screen positive | 35.22 | 10.32 | 129 | 674740 | 5711 | 70247864 |
Diffuse large B-cell lymphoma | 35.04 | 10.32 | 45 | 674824 | 13257 | 70240318 |
Unintentional medical device removal | 35.01 | 10.32 | 12 | 674857 | 7112 | 70246463 |
Haematocrit decreased | 34.89 | 10.32 | 751 | 674118 | 56507 | 70197068 |
Injection site pruritus | 34.82 | 10.32 | 224 | 674645 | 38986 | 70214589 |
Enthesopathy | 34.68 | 10.32 | 199 | 674670 | 10670 | 70242905 |
Hepatic cancer | 34.53 | 10.32 | 25 | 674844 | 9658 | 70243917 |
Congestive cardiomyopathy | 34.26 | 10.32 | 32 | 674837 | 10894 | 70242681 |
Pulmonary alveolar haemorrhage | 34.16 | 10.32 | 29 | 674840 | 10340 | 70243235 |
Pancreatitis acute | 33.56 | 10.32 | 272 | 674597 | 44952 | 70208623 |
Iron deficiency anaemia | 33.53 | 10.32 | 110 | 674759 | 22962 | 70230613 |
Bone erosion | 33.48 | 10.32 | 58 | 674811 | 15115 | 70238460 |
Cytomegalovirus viraemia | 33.48 | 10.32 | 37 | 674832 | 11648 | 70241927 |
Hepatitis C | 33.04 | 10.32 | 44 | 674825 | 12763 | 70240812 |
Eosinophilia | 32.99 | 10.32 | 236 | 674633 | 40083 | 70213492 |
Status epilepticus | 32.90 | 10.32 | 121 | 674748 | 24405 | 70229170 |
Pancreatic carcinoma | 32.62 | 10.32 | 45 | 674824 | 12859 | 70240716 |
Coronary arterial stent insertion | 32.45 | 10.32 | 8 | 674861 | 5879 | 70247696 |
Epstein-Barr virus infection | 32.39 | 10.32 | 47 | 674822 | 13151 | 70240424 |
Tenosynovitis | 32.37 | 10.32 | 236 | 674633 | 13740 | 70239835 |
Circulatory collapse | 32.36 | 10.32 | 201 | 674668 | 35273 | 70218302 |
Drug specific antibody present | 32.08 | 10.32 | 124 | 674745 | 5634 | 70247941 |
Metastases to liver | 31.94 | 10.32 | 132 | 674737 | 25746 | 70227829 |
Ear infection | 31.91 | 10.32 | 411 | 674458 | 27925 | 70225650 |
Hepatic failure | 31.72 | 10.32 | 745 | 674124 | 56880 | 70196695 |
Pharyngitis | 31.44 | 10.32 | 314 | 674555 | 20037 | 70233538 |
Haemoglobin urine present | 31.40 | 10.32 | 40 | 674829 | 827 | 70252748 |
Oropharyngeal pain | 31.32 | 10.32 | 1166 | 673703 | 95144 | 70158431 |
Hyperlipidaemia | 31.18 | 10.32 | 119 | 674750 | 23744 | 70229831 |
Heart rate abnormal | 31.06 | 10.32 | 121 | 674748 | 5518 | 70248057 |
Treatment noncompliance | 31.05 | 10.32 | 288 | 674581 | 46286 | 70207289 |
Asthma | 31.03 | 10.32 | 893 | 673976 | 119900 | 70133675 |
Infusion site mass | 31.01 | 10.32 | 47 | 674822 | 1150 | 70252425 |
Renal cancer | 30.97 | 10.32 | 40 | 674829 | 11756 | 70241819 |
Gastric cancer | 30.80 | 10.32 | 24 | 674845 | 8931 | 70244644 |
Coeliac disease | 30.55 | 10.32 | 168 | 674701 | 8865 | 70244710 |
Pleural effusion | 30.52 | 10.32 | 997 | 673872 | 131867 | 70121708 |
Hyperhidrosis | 30.49 | 10.32 | 1538 | 673331 | 130048 | 70123527 |
Mitral valve incompetence | 30.16 | 10.32 | 141 | 674728 | 26587 | 70226988 |
Left ventricular dysfunction | 30.16 | 10.32 | 80 | 674789 | 17877 | 70235698 |
Extrapyramidal disorder | 30.10 | 10.32 | 99 | 674770 | 20651 | 70232924 |
Brain death | 30.07 | 10.32 | 113 | 674756 | 5065 | 70248510 |
Renal cortical necrosis | 29.94 | 10.32 | 25 | 674844 | 306 | 70253269 |
Sexual dysfunction | 29.94 | 10.32 | 13 | 674856 | 6668 | 70246907 |
Upper gastrointestinal haemorrhage | 29.87 | 10.32 | 221 | 674648 | 37256 | 70216319 |
Oral pruritus | 29.70 | 10.32 | 61 | 674808 | 1910 | 70251665 |
C-reactive protein abnormal | 29.60 | 10.32 | 524 | 674345 | 38055 | 70215520 |
Renal papillary necrosis | 29.51 | 10.32 | 26 | 674843 | 344 | 70253231 |
Incorrect drug administration rate | 29.47 | 10.32 | 81 | 674788 | 3071 | 70250504 |
Coma | 29.40 | 10.32 | 1110 | 673759 | 90734 | 70162841 |
Device difficult to use | 29.31 | 10.32 | 36 | 674833 | 10813 | 70242762 |
Injection site mass | 29.11 | 10.32 | 84 | 674785 | 18259 | 70235316 |
Metastases to lymph nodes | 29.03 | 10.32 | 27 | 674842 | 9211 | 70244364 |
Angina unstable | 28.88 | 10.32 | 68 | 674801 | 15825 | 70237750 |
Incorrect dose administered by device | 28.72 | 10.32 | 4 | 674865 | 4425 | 70249150 |
Anxiety | 28.52 | 10.32 | 2451 | 672418 | 217879 | 70035696 |
Device use error | 28.50 | 10.32 | 14 | 674855 | 6682 | 70246893 |
Drug ineffective for unapproved indication | 28.50 | 10.32 | 232 | 674637 | 38306 | 70215269 |
Macular oedema | 28.48 | 10.32 | 7 | 674862 | 5155 | 70248420 |
Cytopenia | 28.47 | 10.32 | 78 | 674791 | 17245 | 70236330 |
Anticipatory anxiety | 28.47 | 10.32 | 41 | 674828 | 957 | 70252618 |
Electrolyte imbalance | 28.40 | 10.32 | 145 | 674724 | 26716 | 70226859 |
Back pain | 28.36 | 10.32 | 2971 | 671898 | 268181 | 69985394 |
Nocardiosis | 28.21 | 10.32 | 7 | 674862 | 5122 | 70248453 |
Hepatitis B reactivation | 28.14 | 10.32 | 8 | 674861 | 5347 | 70248228 |
Cardiomyopathy | 28.09 | 10.32 | 142 | 674727 | 26231 | 70227344 |
Hypertriglyceridaemia | 28.07 | 10.32 | 43 | 674826 | 11768 | 70241807 |
Breast cancer stage II | 28.07 | 10.32 | 8 | 674861 | 5338 | 70248237 |
Disease recurrence | 27.97 | 10.32 | 226 | 674643 | 37377 | 70216198 |
Stomatitis | 27.93 | 10.32 | 1493 | 673376 | 127018 | 70126557 |
Injection site warmth | 27.72 | 10.32 | 56 | 674813 | 13769 | 70239806 |
Breast cancer | 27.63 | 10.32 | 196 | 674673 | 33353 | 70220222 |
Immunosuppressant drug level increased | 27.44 | 10.32 | 21 | 674848 | 7886 | 70245689 |
Acute graft versus host disease in skin | 27.37 | 10.32 | 17 | 674852 | 7120 | 70246455 |
Aplastic anaemia | 27.33 | 10.32 | 261 | 674608 | 16455 | 70237120 |
Metastases to lung | 27.26 | 10.32 | 74 | 674795 | 16410 | 70237165 |
Shock haemorrhagic | 27.23 | 10.32 | 85 | 674784 | 18021 | 70235554 |
Rheumatoid arthritis | 27.18 | 10.32 | 3173 | 671696 | 288632 | 69964943 |
Deafness transitory | 27.12 | 10.32 | 39 | 674830 | 909 | 70252666 |
Device dislocation | 27.04 | 10.32 | 116 | 674753 | 22391 | 70231184 |
Disturbance in attention | 27.00 | 10.32 | 269 | 674600 | 42625 | 70210950 |
Brain oedema | 26.93 | 10.32 | 341 | 674528 | 23077 | 70230498 |
Drug dose omission by device | 26.86 | 10.32 | 4 | 674865 | 4208 | 70249367 |
BK virus infection | 26.74 | 10.32 | 22 | 674847 | 7967 | 70245608 |
Parkinsonism | 26.72 | 10.32 | 67 | 674802 | 15258 | 70238317 |
Oedema | 26.54 | 10.32 | 766 | 674103 | 102815 | 70150760 |
Obstructive airways disorder | 26.47 | 10.32 | 143 | 674726 | 25970 | 70227605 |
Migraine | 26.32 | 10.32 | 886 | 673983 | 71352 | 70182223 |
Sinus node dysfunction | 26.23 | 10.32 | 18 | 674851 | 7151 | 70246424 |
Contusion | 26.16 | 10.32 | 1479 | 673390 | 126557 | 70127018 |
Varicella zoster virus infection | 26.07 | 10.32 | 4 | 674865 | 4116 | 70249459 |
Myalgia | 26.07 | 10.32 | 1318 | 673551 | 166574 | 70087001 |
Graft versus host disease in gastrointestinal tract | 25.95 | 10.32 | 12 | 674857 | 5932 | 70247643 |
Infusion site discomfort | 25.92 | 10.32 | 39 | 674830 | 948 | 70252627 |
Hypoglycaemic coma | 25.91 | 10.32 | 5 | 674864 | 4356 | 70249219 |
Analgesic drug level above therapeutic | 25.83 | 10.32 | 27 | 674842 | 447 | 70253128 |
Leukoencephalopathy | 25.79 | 10.32 | 19 | 674850 | 7275 | 70246300 |
Coronary artery bypass | 25.77 | 10.32 | 12 | 674857 | 5908 | 70247667 |
Pulmonary tuberculosis | 25.77 | 10.32 | 22 | 674847 | 7823 | 70245752 |
Haematochezia | 25.75 | 10.32 | 515 | 674354 | 72566 | 70181009 |
Eosinophil percentage increased | 25.64 | 10.32 | 48 | 674821 | 1402 | 70252173 |
Disorientation | 25.59 | 10.32 | 392 | 674477 | 57531 | 70196044 |
Anion gap increased | 25.59 | 10.32 | 78 | 674791 | 3138 | 70250437 |
Visual impairment | 25.50 | 10.32 | 575 | 674294 | 79675 | 70173900 |
Full blood count decreased | 25.35 | 10.32 | 129 | 674740 | 23789 | 70229786 |
Systemic lupus erythematosus rash | 25.29 | 10.32 | 51 | 674818 | 1576 | 70251999 |
Device issue | 25.23 | 10.32 | 130 | 674739 | 23895 | 70229680 |
Large intestine polyp | 25.20 | 10.32 | 44 | 674825 | 11432 | 70242143 |
Gynaecomastia | 25.14 | 10.32 | 17 | 674852 | 6806 | 70246769 |
Night sweats | 25.04 | 10.32 | 568 | 674301 | 43116 | 70210459 |
Prostatic specific antigen increased | 24.96 | 10.32 | 32 | 674837 | 9434 | 70244141 |
Blood creatine phosphokinase increased | 24.93 | 10.32 | 421 | 674448 | 60842 | 70192733 |
Premature delivery | 24.86 | 10.32 | 111 | 674758 | 21193 | 70232382 |
Nitrite urine present | 24.85 | 10.32 | 42 | 674827 | 1130 | 70252445 |
Haematoma | 24.83 | 10.32 | 318 | 674551 | 48100 | 70205475 |
Toxicologic test abnormal | 24.82 | 10.32 | 45 | 674824 | 1282 | 70252293 |
Surgery | 24.79 | 10.32 | 175 | 674694 | 29814 | 70223761 |
Ejection fraction decreased | 24.71 | 10.32 | 181 | 674688 | 30581 | 70222994 |
Lipodystrophy acquired | 24.70 | 10.32 | 5 | 674864 | 4211 | 70249364 |
Aphasia | 24.49 | 10.32 | 278 | 674591 | 42971 | 70210604 |
Long QT syndrome | 24.46 | 10.32 | 10 | 674859 | 5317 | 70248258 |
Mobility decreased | 24.29 | 10.32 | 1206 | 673663 | 101793 | 70151782 |
Mean cell haemoglobin concentration decreased | 24.21 | 10.32 | 90 | 674779 | 4013 | 70249562 |
Human herpesvirus 6 infection | 24.20 | 10.32 | 8 | 674861 | 4851 | 70248724 |
Metastases to bone | 24.11 | 10.32 | 120 | 674749 | 22256 | 70231319 |
Spinal stenosis | 24.07 | 10.32 | 66 | 674803 | 14587 | 70238988 |
Device leakage | 23.99 | 10.32 | 32 | 674837 | 9276 | 70244299 |
Kidney transplant rejection | 23.93 | 10.32 | 36 | 674833 | 9925 | 70243650 |
Blood glucose increased | 23.83 | 10.32 | 772 | 674097 | 102210 | 70151365 |
Cystitis haemorrhagic | 23.76 | 10.32 | 28 | 674841 | 8565 | 70245010 |
Depression | 23.70 | 10.32 | 1602 | 673267 | 197372 | 70056203 |
Prothrombin time prolonged | 23.67 | 10.32 | 247 | 674622 | 15943 | 70237632 |
Graft versus host disease in skin | 23.62 | 10.32 | 12 | 674857 | 5618 | 70247957 |
Injection site reaction | 23.54 | 10.32 | 333 | 674536 | 49519 | 70204056 |
Electrocardiogram QRS complex prolonged | 23.53 | 10.32 | 167 | 674702 | 9639 | 70243936 |
Product quality issue | 23.51 | 10.32 | 182 | 674687 | 30379 | 70223196 |
Candida infection | 23.49 | 10.32 | 212 | 674657 | 34261 | 70219314 |
Partial seizures | 23.48 | 10.32 | 26 | 674843 | 8179 | 70245396 |
Disturbance in social behaviour | 23.47 | 10.32 | 5 | 674864 | 4062 | 70249513 |
Arrhythmia | 23.44 | 10.32 | 384 | 674485 | 55759 | 70197816 |
Venoocclusive liver disease | 23.40 | 10.32 | 41 | 674828 | 10637 | 70242938 |
Rheumatic fever | 23.31 | 10.32 | 264 | 674605 | 17396 | 70236179 |
Ischaemic cardiomyopathy | 23.24 | 10.32 | 20 | 674849 | 7084 | 70246491 |
Ketoacidosis | 23.13 | 10.32 | 21 | 674848 | 7248 | 70246327 |
Hyperglycaemia | 23.01 | 10.32 | 455 | 674414 | 64217 | 70189358 |
Lymphoproliferative disorder | 22.90 | 10.32 | 11 | 674858 | 5318 | 70248257 |
Suicidal ideation | 22.88 | 10.32 | 496 | 674373 | 69100 | 70184475 |
Drug reaction with eosinophilia and systemic symptoms | 22.86 | 10.32 | 401 | 674468 | 57612 | 70195963 |
Bilirubin urine present | 22.81 | 10.32 | 22 | 674847 | 329 | 70253246 |
Fibromyalgia | 22.80 | 10.32 | 607 | 674262 | 47267 | 70206308 |
Tooth infection | 22.60 | 10.32 | 248 | 674621 | 16215 | 70237360 |
Neuroleptic malignant syndrome | 22.37 | 10.32 | 150 | 674719 | 25857 | 70227718 |
Forced expiratory volume decreased | 22.26 | 10.32 | 22 | 674847 | 7292 | 70246283 |
Infusion site rash | 22.21 | 10.32 | 43 | 674826 | 1289 | 70252286 |
Tuberculosis | 22.12 | 10.32 | 70 | 674799 | 14778 | 70238797 |
Gestational diabetes | 22.05 | 10.32 | 15 | 674854 | 5986 | 70247589 |
Hypothyroidism | 21.83 | 10.32 | 305 | 674564 | 45450 | 70208125 |
Haemophagocytic lymphohistiocytosis | 21.81 | 10.32 | 104 | 674765 | 19508 | 70234067 |
Acute respiratory failure | 21.77 | 10.32 | 369 | 674500 | 53296 | 70200279 |
Victim of child abuse | 21.75 | 10.32 | 35 | 674834 | 903 | 70252672 |
Metastases to central nervous system | 21.62 | 10.32 | 72 | 674797 | 14962 | 70238613 |
Meningitis aseptic | 21.45 | 10.32 | 119 | 674750 | 6300 | 70247275 |
Accidental exposure to product by child | 21.35 | 10.32 | 67 | 674802 | 2739 | 70250836 |
Injection site rash | 21.33 | 10.32 | 82 | 674787 | 16328 | 70237247 |
Cytomegalovirus infection reactivation | 21.10 | 10.32 | 20 | 674849 | 6761 | 70246814 |
Injection site extravasation | 21.01 | 10.32 | 149 | 674720 | 8597 | 70244978 |
Alanine aminotransferase abnormal | 20.96 | 10.32 | 140 | 674729 | 7919 | 70245656 |
Acute coronary syndrome | 20.88 | 10.32 | 109 | 674760 | 19970 | 70233605 |
Blood loss anaemia | 20.88 | 10.32 | 69 | 674800 | 14372 | 70239203 |
Unevaluable event | 20.79 | 10.32 | 359 | 674510 | 51704 | 70201871 |
Haemolysis | 20.73 | 10.32 | 184 | 674685 | 11367 | 70242208 |
Diffuse large B-cell lymphoma recurrent | 20.62 | 10.32 | 4 | 674865 | 3472 | 70250103 |
Actinic keratosis | 20.50 | 10.32 | 14 | 674855 | 5576 | 70247999 |
Aggression | 20.35 | 10.32 | 331 | 674538 | 48115 | 70205460 |
Infusion site urticaria | 20.30 | 10.32 | 32 | 674837 | 811 | 70252764 |
Bradyphrenia | 20.19 | 10.32 | 40 | 674829 | 9906 | 70243669 |
Hypovolaemic shock | 19.98 | 10.32 | 46 | 674823 | 10791 | 70242784 |
Blood creatinine decreased | 19.93 | 10.32 | 129 | 674740 | 7220 | 70246355 |
Sudden death | 19.92 | 10.32 | 118 | 674751 | 20946 | 70232629 |
Soft tissue disorder | 19.90 | 10.32 | 74 | 674795 | 3300 | 70250275 |
Hepatitis B | 19.81 | 10.32 | 29 | 674840 | 8085 | 70245490 |
Rheumatoid nodule | 19.78 | 10.32 | 225 | 674644 | 14842 | 70238733 |
Cardiac disorder | 19.66 | 10.32 | 423 | 674446 | 58992 | 70194583 |
Squamous cell carcinoma of skin | 19.60 | 10.32 | 59 | 674810 | 12653 | 70240922 |
Concomitant disease aggravated | 19.57 | 10.32 | 55 | 674814 | 12059 | 70241516 |
Carotid artery stenosis | 19.56 | 10.32 | 30 | 674839 | 8206 | 70245369 |
Personality change | 19.49 | 10.32 | 34 | 674835 | 8836 | 70244739 |
Cholestasis | 19.47 | 10.32 | 329 | 674540 | 47543 | 70206032 |
Aplasia pure red cell | 19.37 | 10.32 | 25 | 674844 | 7349 | 70246226 |
Hypomagnesaemia | 19.35 | 10.32 | 272 | 674597 | 40492 | 70213083 |
Skin toxicity | 19.32 | 10.32 | 24 | 674845 | 7174 | 70246401 |
Fracture | 19.24 | 10.32 | 111 | 674758 | 19833 | 70233742 |
JC virus infection | 19.23 | 10.32 | 5 | 674864 | 3546 | 70250029 |
Pneumonia viral | 19.19 | 10.32 | 140 | 674729 | 8152 | 70245423 |
Adenocarcinoma of colon | 19.12 | 10.32 | 14 | 674855 | 5378 | 70248197 |
B-cell lymphoma | 18.91 | 10.32 | 19 | 674850 | 6250 | 70247325 |
Sleep disorder due to a general medical condition | 18.89 | 10.32 | 45 | 674824 | 10431 | 70243144 |
Infusion site streaking | 18.87 | 10.32 | 23 | 674846 | 454 | 70253121 |
pH urine increased | 18.85 | 10.32 | 22 | 674847 | 414 | 70253161 |
Multiple drug therapy | 18.82 | 10.32 | 70 | 674799 | 3122 | 70250453 |
Hyperammonaemia | 18.73 | 10.32 | 44 | 674825 | 10249 | 70243326 |
Emotional distress | 18.73 | 10.32 | 475 | 674394 | 36713 | 70216862 |
Subarachnoid haemorrhage | 18.58 | 10.32 | 109 | 674760 | 19395 | 70234180 |
Serum sickness-like reaction | 18.56 | 10.32 | 25 | 674844 | 547 | 70253028 |
Tachyarrhythmia | 18.51 | 10.32 | 20 | 674849 | 6362 | 70247213 |
Red blood cell sedimentation rate | 18.44 | 10.32 | 94 | 674775 | 4816 | 70248759 |
Transplant failure | 18.39 | 10.32 | 8 | 674861 | 4099 | 70249476 |
Compartment syndrome | 18.36 | 10.32 | 88 | 674781 | 4398 | 70249177 |
Squamous cell carcinoma | 18.33 | 10.32 | 74 | 674795 | 14530 | 70239045 |
Loss of consciousness | 18.33 | 10.32 | 1255 | 673614 | 154461 | 70099114 |
Mucormycosis | 18.27 | 10.32 | 30 | 674839 | 7984 | 70245591 |
Sinus tachycardia | 18.22 | 10.32 | 437 | 674432 | 33476 | 70220099 |
Petit mal epilepsy | 18.21 | 10.32 | 15 | 674854 | 5429 | 70248146 |
Antipsychotic drug level increased | 18.18 | 10.32 | 15 | 674854 | 5425 | 70248150 |
Mast cell activation syndrome | 18.18 | 10.32 | 26 | 674843 | 603 | 70252972 |
Peripheral arterial occlusive disease | 18.17 | 10.32 | 27 | 674842 | 7482 | 70246093 |
Band neutrophil count increased | 18.14 | 10.32 | 27 | 674842 | 650 | 70252925 |
Erectile dysfunction | 18.13 | 10.32 | 67 | 674802 | 13495 | 70240080 |
Intentional self-injury | 18.09 | 10.32 | 203 | 674666 | 31447 | 70222128 |
No adverse event | 18.08 | 10.32 | 207 | 674662 | 31946 | 70221629 |
Dizziness | 18.07 | 10.32 | 4024 | 670845 | 460117 | 69793458 |
Pharyngeal swelling | 17.95 | 10.32 | 114 | 674755 | 6339 | 70247236 |
Atypical femur fracture | 17.94 | 10.32 | 12 | 674857 | 4831 | 70248744 |
Muscle spasticity | 17.91 | 10.32 | 275 | 674594 | 19414 | 70234161 |
Granulomatosis with polyangiitis | 17.87 | 10.32 | 60 | 674809 | 2542 | 70251033 |
Nocturia | 17.86 | 10.32 | 58 | 674811 | 12146 | 70241429 |
Therapy partial responder | 17.76 | 10.32 | 60 | 674809 | 12414 | 70241161 |
Akinesia | 17.76 | 10.32 | 4 | 674865 | 3127 | 70250448 |
Cytomegalovirus colitis | 17.74 | 10.32 | 9 | 674860 | 4217 | 70249358 |
Bundle branch block left | 17.71 | 10.32 | 46 | 674823 | 10353 | 70243222 |
Gastritis erosive | 17.70 | 10.32 | 44 | 674825 | 10051 | 70243524 |
Administration site swelling | 17.70 | 10.32 | 20 | 674849 | 363 | 70253212 |
Injection site induration | 17.66 | 10.32 | 38 | 674831 | 9130 | 70244445 |
Cardiovascular disorder | 17.62 | 10.32 | 90 | 674779 | 16580 | 70236995 |
Ageusia | 17.61 | 10.32 | 77 | 674792 | 14785 | 70238790 |
Erysipelas | 17.60 | 10.32 | 43 | 674826 | 9881 | 70243694 |
Gastrooesophageal reflux disease | 17.59 | 10.32 | 696 | 674173 | 90143 | 70163432 |
Anuria | 17.59 | 10.32 | 112 | 674757 | 19541 | 70234034 |
Rectal haemorrhage | 17.58 | 10.32 | 484 | 674385 | 65347 | 70188228 |
Pneumatosis intestinalis | 17.58 | 10.32 | 18 | 674851 | 5869 | 70247706 |
Hemiparesis | 17.53 | 10.32 | 203 | 674666 | 31266 | 70222309 |
Dysarthria | 17.46 | 10.32 | 455 | 674414 | 61858 | 70191717 |
Pupil fixed | 17.46 | 10.32 | 71 | 674798 | 3303 | 70250272 |
Hypervolaemia | 17.44 | 10.32 | 269 | 674600 | 39437 | 70214138 |
Dyspnoea | 17.43 | 10.32 | 6830 | 668039 | 763230 | 69490345 |
Cardiotoxicity | 17.34 | 10.32 | 51 | 674818 | 11019 | 70242556 |
Anal fissure | 17.26 | 10.32 | 110 | 674759 | 6123 | 70247452 |
Cytomegalovirus chorioretinitis | 17.23 | 10.32 | 15 | 674854 | 5283 | 70248292 |
Pneumonia aspiration | 17.15 | 10.32 | 456 | 674413 | 61833 | 70191742 |
Vitamin K deficiency | 17.11 | 10.32 | 27 | 674842 | 685 | 70252890 |
Urinary casts | 17.09 | 10.32 | 36 | 674833 | 1148 | 70252427 |
Product use issue | 17.05 | 10.32 | 1959 | 672910 | 177978 | 70075597 |
Mental status changes | 17.05 | 10.32 | 749 | 674120 | 62352 | 70191223 |
Adrenergic syndrome | 17.01 | 10.32 | 12 | 674857 | 112 | 70253463 |
Osteoarthritis | 16.87 | 10.32 | 557 | 674312 | 73590 | 70179985 |
Infusion site nodule | 16.82 | 10.32 | 17 | 674852 | 270 | 70253305 |
Thrombosis | 16.80 | 10.32 | 568 | 674301 | 74837 | 70178738 |
Periorbital swelling | 16.74 | 10.32 | 53 | 674816 | 2177 | 70251398 |
Self-medication | 16.65 | 10.32 | 85 | 674784 | 4358 | 70249217 |
Proteinuria | 16.56 | 10.32 | 189 | 674680 | 29185 | 70224390 |
Haematemesis | 16.55 | 10.32 | 346 | 674523 | 48451 | 70205124 |
Retinal haemorrhage | 16.54 | 10.32 | 30 | 674839 | 7680 | 70245895 |
Dyslipidaemia | 16.50 | 10.32 | 44 | 674825 | 9816 | 70243759 |
Abnormal dreams | 16.50 | 10.32 | 49 | 674820 | 10554 | 70243021 |
Cells in urine | 16.40 | 10.32 | 15 | 674854 | 209 | 70253366 |
Band neutrophil percentage increased | 16.40 | 10.32 | 20 | 674849 | 395 | 70253180 |
Vein rupture | 16.32 | 10.32 | 44 | 674825 | 1649 | 70251926 |
Cerebral ischaemia | 16.29 | 10.32 | 48 | 674821 | 10364 | 70243211 |
Haemorrhage intracranial | 16.18 | 10.32 | 154 | 674715 | 24623 | 70228952 |
Left ventricular failure | 16.13 | 10.32 | 37 | 674832 | 8691 | 70244884 |
Peritonitis bacterial | 16.13 | 10.32 | 40 | 674829 | 9144 | 70244431 |
Weight fluctuation | 16.11 | 10.32 | 150 | 674719 | 9391 | 70244184 |
Vertigo | 16.11 | 10.32 | 463 | 674406 | 62180 | 70191395 |
Oropharyngeal discomfort | 16.05 | 10.32 | 106 | 674763 | 5973 | 70247602 |
White coat hypertension | 15.99 | 10.32 | 26 | 674843 | 677 | 70252898 |
Pneumonia cytomegaloviral | 15.97 | 10.32 | 12 | 674857 | 4549 | 70249026 |
Haemoptysis | 15.97 | 10.32 | 370 | 674499 | 51082 | 70202493 |
Pain in jaw | 15.85 | 10.32 | 298 | 674571 | 42371 | 70211204 |
COVID-19 immunisation | 15.82 | 10.32 | 33 | 674836 | 1045 | 70252530 |
Coagulation factor X level decreased | 15.74 | 10.32 | 11 | 674858 | 101 | 70253474 |
Bradyarrhythmia | 15.74 | 10.32 | 9 | 674860 | 3944 | 70249631 |
Complications of transplanted kidney | 15.71 | 10.32 | 20 | 674849 | 5914 | 70247661 |
Peritonitis | 15.66 | 10.32 | 166 | 674703 | 25993 | 70227582 |
Product dispensing error | 15.61 | 10.32 | 60 | 674809 | 11948 | 70241627 |
Post-traumatic stress disorder | 15.61 | 10.32 | 83 | 674786 | 4324 | 70249251 |
Physical disability | 15.60 | 10.32 | 4 | 674865 | 2863 | 70250712 |
Urticaria thermal | 15.59 | 10.32 | 16 | 674853 | 259 | 70253316 |
Brain stem glioma | 15.52 | 10.32 | 15 | 674854 | 225 | 70253350 |
Muscle spasms | 15.50 | 10.32 | 1258 | 673611 | 152788 | 70100787 |
Eyelid ptosis | 15.50 | 10.32 | 47 | 674822 | 10055 | 70243520 |
Staphylococcal infection | 15.48 | 10.32 | 388 | 674481 | 53016 | 70200559 |
Progressive multifocal leukoencephalopathy | 15.46 | 10.32 | 113 | 674756 | 19101 | 70234474 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 15.45 | 10.32 | 6 | 674863 | 3291 | 70250284 |
Acidosis | 15.44 | 10.32 | 252 | 674617 | 18011 | 70235564 |
Pericardial effusion | 15.44 | 10.32 | 292 | 674577 | 41484 | 70212091 |
Leukaemia | 15.42 | 10.32 | 17 | 674852 | 5358 | 70248217 |
Urobilinogen urine increased | 15.37 | 10.32 | 25 | 674844 | 651 | 70252924 |
Sputum culture positive | 15.36 | 10.32 | 68 | 674801 | 3286 | 70250289 |
Cystic fibrosis pancreatic | 15.34 | 10.32 | 9 | 674860 | 59 | 70253516 |
Fungal rhinitis | 15.34 | 10.32 | 9 | 674860 | 59 | 70253516 |
Terminal state | 15.34 | 10.32 | 13 | 674856 | 4639 | 70248936 |
Oxygen saturation abnormal | 15.34 | 10.32 | 75 | 674794 | 3779 | 70249796 |
Mycobacterial infection | 15.29 | 10.32 | 7 | 674862 | 3481 | 70250094 |
Malignant melanoma | 15.29 | 10.32 | 74 | 674795 | 13826 | 70239749 |
Lower gastrointestinal haemorrhage | 15.26 | 10.32 | 80 | 674789 | 14640 | 70238935 |
Pulmonary fibrosis | 15.22 | 10.32 | 232 | 674637 | 34078 | 70219497 |
Intestinal haemorrhage | 15.21 | 10.32 | 21 | 674848 | 5999 | 70247576 |
Swollen joint count increased | 15.13 | 10.32 | 198 | 674671 | 13502 | 70240073 |
Dyspnoea at rest | 15.11 | 10.32 | 26 | 674843 | 6793 | 70246782 |
Electrocardiogram QT prolonged | 15.09 | 10.32 | 645 | 674224 | 82872 | 70170703 |
Joint injury | 15.07 | 10.32 | 349 | 674520 | 26583 | 70226992 |
Cystitis | 14.94 | 10.32 | 567 | 674302 | 46374 | 70207201 |
Monoparesis | 14.89 | 10.32 | 6 | 674863 | 3218 | 70250357 |
Femoral neck fracture | 14.80 | 10.32 | 41 | 674828 | 9032 | 70244543 |
Diplopia | 14.75 | 10.32 | 184 | 674685 | 27963 | 70225612 |
Drug use disorder | 14.71 | 10.32 | 130 | 674739 | 8021 | 70245554 |
Thyroxine free increased | 14.65 | 10.32 | 34 | 674835 | 1159 | 70252416 |
Pemphigoid | 14.65 | 10.32 | 76 | 674793 | 13946 | 70239629 |
Lung disorder | 14.65 | 10.32 | 527 | 674342 | 68957 | 70184618 |
Jaundice | 14.54 | 10.32 | 364 | 674505 | 49744 | 70203831 |
Biliary dyskinesia | 14.47 | 10.32 | 53 | 674816 | 2346 | 70251229 |
Urine bilirubin decreased | 14.43 | 10.32 | 12 | 674857 | 146 | 70253429 |
Somnolence | 14.42 | 10.32 | 2299 | 672570 | 213307 | 70040268 |
Diastolic dysfunction | 14.39 | 10.32 | 44 | 674825 | 9389 | 70244186 |
Joint laxity | 14.39 | 10.32 | 52 | 674817 | 2287 | 70251288 |
Mean cell haemoglobin concentration increased | 14.37 | 10.32 | 27 | 674842 | 791 | 70252784 |
Tri-iodothyronine free increased | 14.37 | 10.32 | 15 | 674854 | 248 | 70253327 |
Nephropathy toxic | 14.36 | 10.32 | 110 | 674759 | 18404 | 70235171 |
Blood thyroid stimulating hormone decreased | 14.34 | 10.32 | 95 | 674774 | 5359 | 70248216 |
Gallbladder injury | 14.33 | 10.32 | 33 | 674836 | 1119 | 70252456 |
Atrioventricular block complete | 14.31 | 10.32 | 85 | 674784 | 15078 | 70238497 |
Red blood cells urine | 14.27 | 10.32 | 24 | 674845 | 643 | 70252932 |
Spinal compression fracture | 14.25 | 10.32 | 88 | 674781 | 15465 | 70238110 |
Infusion site scar | 14.22 | 10.32 | 16 | 674853 | 289 | 70253286 |
Peripheral sensory neuropathy | 14.19 | 10.32 | 63 | 674806 | 12047 | 70241528 |
Euglycaemic diabetic ketoacidosis | 14.15 | 10.32 | 22 | 674847 | 5985 | 70247590 |
Colon cancer | 14.14 | 10.32 | 79 | 674790 | 14227 | 70239348 |
Diverticulum intestinal | 14.14 | 10.32 | 35 | 674834 | 8006 | 70245569 |
Blood pressure decreased | 14.11 | 10.32 | 1032 | 673837 | 90483 | 70163092 |
Disseminated tuberculosis | 14.09 | 10.32 | 11 | 674858 | 4089 | 70249486 |
Klebsiella infection | 14.08 | 10.32 | 79 | 674790 | 14213 | 70239362 |
Limb mass | 14.00 | 10.32 | 66 | 674803 | 3276 | 70250299 |
Hip fracture | 13.99 | 10.32 | 187 | 674682 | 28076 | 70225499 |
Intraocular pressure increased | 13.95 | 10.32 | 41 | 674828 | 8860 | 70244715 |
Malaise | 13.94 | 10.32 | 3786 | 671083 | 429146 | 69824429 |
Rash maculo-papular | 13.92 | 10.32 | 370 | 674499 | 50175 | 70203400 |
Viral load increased | 13.90 | 10.32 | 4 | 674865 | 2652 | 70250923 |
Uterine cancer | 13.89 | 10.32 | 8 | 674861 | 3491 | 70250084 |
Cerebral haematoma | 13.86 | 10.32 | 31 | 674838 | 7347 | 70246228 |
Generalised bullous fixed drug eruption | 13.84 | 10.32 | 11 | 674858 | 125 | 70253450 |
Metastasis | 13.83 | 10.32 | 23 | 674846 | 6091 | 70247484 |
Epstein-Barr virus associated lymphoproliferative disorder | 13.81 | 10.32 | 7 | 674862 | 3282 | 70250293 |
Abdominal discomfort | 13.80 | 10.32 | 2284 | 672585 | 212374 | 70041201 |
Skin cancer | 13.79 | 10.32 | 74 | 674795 | 13462 | 70240113 |
Head injury | 13.77 | 10.32 | 235 | 674634 | 33906 | 70219669 |
Accidental poisoning | 13.71 | 10.32 | 40 | 674829 | 1570 | 70252005 |
Gastric haemorrhage | 13.66 | 10.32 | 79 | 674790 | 14106 | 70239469 |
White blood cells urine | 13.63 | 10.32 | 18 | 674851 | 386 | 70253189 |
Embolism venous | 13.62 | 10.32 | 10 | 674859 | 3835 | 70249740 |
Acute myeloid leukaemia recurrent | 13.59 | 10.32 | 6 | 674863 | 3048 | 70250527 |
Brain abscess | 13.59 | 10.32 | 14 | 674855 | 4552 | 70249023 |
Feeling cold | 13.59 | 10.32 | 329 | 674540 | 25241 | 70228334 |
Procedural anxiety | 13.58 | 10.32 | 24 | 674845 | 670 | 70252905 |
Retinal deposits | 13.56 | 10.32 | 11 | 674858 | 129 | 70253446 |
Toxoplasmosis | 13.53 | 10.32 | 4 | 674865 | 2606 | 70250969 |
Adenovirus infection | 13.51 | 10.32 | 34 | 674835 | 7734 | 70245841 |
Hot flush | 13.50 | 10.32 | 589 | 674280 | 48995 | 70204580 |
Pleurothotonus | 13.47 | 10.32 | 3 | 674866 | 2363 | 70251212 |
Stress | 13.47 | 10.32 | 783 | 674086 | 67183 | 70186392 |
Abdominal pain | 13.46 | 10.32 | 3555 | 671314 | 338572 | 69915003 |
Colitis | 13.45 | 10.32 | 484 | 674385 | 63330 | 70190245 |
Lipaemic index score | 13.42 | 10.32 | 11 | 674858 | 131 | 70253444 |
Electric shock sensation | 13.42 | 10.32 | 22 | 674847 | 577 | 70252998 |
Acute graft versus host disease in intestine | 13.41 | 10.32 | 10 | 674859 | 3806 | 70249769 |
Ear swelling | 13.35 | 10.32 | 37 | 674832 | 1410 | 70252165 |
Leukocyturia | 13.30 | 10.32 | 40 | 674829 | 1597 | 70251978 |
Focal dyscognitive seizures | 13.30 | 10.32 | 8 | 674861 | 3409 | 70250166 |
Tricuspid valve incompetence | 13.29 | 10.32 | 107 | 674762 | 17710 | 70235865 |
Portal hypertension | 13.27 | 10.32 | 26 | 674843 | 6466 | 70247109 |
Underdose | 13.27 | 10.32 | 198 | 674671 | 29185 | 70224390 |
Bradycardia | 13.26 | 10.32 | 1013 | 673856 | 123602 | 70129973 |
Eosinophilic granulomatosis with polyangiitis | 13.25 | 10.32 | 7 | 674862 | 3206 | 70250369 |
Left ventricular hypertrophy | 13.25 | 10.32 | 51 | 674818 | 10151 | 70243424 |
Potentiating drug interaction | 13.24 | 10.32 | 37 | 674832 | 8127 | 70245448 |
Infective pulmonary exacerbation of cystic fibrosis | 13.21 | 10.32 | 65 | 674804 | 12093 | 70241482 |
Mastocytosis | 13.21 | 10.32 | 19 | 674850 | 443 | 70253132 |
Idiopathic pulmonary fibrosis | 13.21 | 10.32 | 16 | 674853 | 4835 | 70248740 |
Condition aggravated | 13.16 | 10.32 | 3747 | 671122 | 423888 | 69829687 |
Abortion induced | 13.14 | 10.32 | 27 | 674842 | 6598 | 70246977 |
PCO2 decreased | 13.08 | 10.32 | 60 | 674809 | 2944 | 70250631 |
Agitation | 13.07 | 10.32 | 1045 | 673824 | 92330 | 70161245 |
Hemiplegia | 13.05 | 10.32 | 78 | 674791 | 13817 | 70239758 |
Syringe issue | 13.05 | 10.32 | 19 | 674850 | 5309 | 70248266 |
Invasive ductal breast carcinoma | 13.01 | 10.32 | 22 | 674847 | 5787 | 70247788 |
Delusion | 13.00 | 10.32 | 118 | 674751 | 19047 | 70234528 |
Toothache | 12.97 | 10.32 | 247 | 674622 | 18183 | 70235392 |
Osmolar gap | 12.96 | 10.32 | 11 | 674858 | 138 | 70253437 |
Thyroid cancer | 12.95 | 10.32 | 18 | 674851 | 5127 | 70248448 |
Chronic spontaneous urticaria | 12.92 | 10.32 | 31 | 674838 | 1080 | 70252495 |
Renal tubular disorder | 12.90 | 10.32 | 24 | 674845 | 6086 | 70247489 |
Eye swelling | 12.90 | 10.32 | 305 | 674564 | 23309 | 70230266 |
Blood creatinine increased | 12.87 | 10.32 | 1178 | 673691 | 141823 | 70111752 |
Smear cervix abnormal | 12.86 | 10.32 | 51 | 674818 | 2345 | 70251230 |
Fluid retention | 12.85 | 10.32 | 483 | 674386 | 62902 | 70190673 |
Exposure via inhalation | 12.85 | 10.32 | 9 | 674860 | 83 | 70253492 |
Pneumonia bacterial | 12.85 | 10.32 | 99 | 674770 | 16542 | 70237033 |
Pancreatitis | 12.83 | 10.32 | 477 | 674392 | 62191 | 70191384 |
Pericardial haemorrhage | 12.80 | 10.32 | 13 | 674856 | 4255 | 70249320 |
Coronary artery stenosis | 12.80 | 10.32 | 62 | 674807 | 11582 | 70241993 |
Monocyte count increased | 12.77 | 10.32 | 139 | 674730 | 9070 | 70244505 |
Impaired work ability | 12.71 | 10.32 | 97 | 674772 | 16243 | 70237332 |
Coronary artery occlusion | 12.71 | 10.32 | 82 | 674787 | 14263 | 70239312 |
Muscle twitching | 12.71 | 10.32 | 262 | 674607 | 19565 | 70234010 |
Skin lesion | 12.67 | 10.32 | 274 | 674595 | 38186 | 70215389 |
Fanconi syndrome | 12.61 | 10.32 | 5 | 674864 | 2708 | 70250867 |
Embolic stroke | 12.60 | 10.32 | 32 | 674837 | 7257 | 70246318 |
Nephrogenic systemic fibrosis | 12.58 | 10.32 | 24 | 674845 | 6028 | 70247547 |
Secondary amyloidosis | 12.58 | 10.32 | 12 | 674857 | 177 | 70253398 |
Concomitant disease progression | 12.57 | 10.32 | 8 | 674861 | 3307 | 70250268 |
Immune-mediated myositis | 12.54 | 10.32 | 7 | 674862 | 3109 | 70250466 |
Muscle haemorrhage | 12.53 | 10.32 | 23 | 674846 | 5861 | 70247714 |
Dry throat | 12.50 | 10.32 | 108 | 674761 | 6620 | 70246955 |
Blindness | 12.49 | 10.32 | 151 | 674718 | 23076 | 70230499 |
Maternal exposure timing unspecified | 12.48 | 10.32 | 78 | 674791 | 4313 | 70249262 |
Cardiac tamponade | 12.47 | 10.32 | 41 | 674828 | 8554 | 70245021 |
Mean cell haemoglobin increased | 12.45 | 10.32 | 67 | 674802 | 3506 | 70250069 |
Jaundice cholestatic | 12.44 | 10.32 | 138 | 674731 | 9046 | 70244529 |
Kidney infection | 12.44 | 10.32 | 257 | 674612 | 19198 | 70234377 |
Facial paresis | 12.40 | 10.32 | 18 | 674851 | 5035 | 70248540 |
Pre-eclampsia | 12.39 | 10.32 | 27 | 674842 | 6458 | 70247117 |
Paradoxical drug reaction | 12.37 | 10.32 | 28 | 674841 | 6608 | 70246967 |
Lung adenocarcinoma | 12.36 | 10.32 | 35 | 674834 | 7655 | 70245920 |
Facet joint syndrome | 12.36 | 10.32 | 100 | 674769 | 6013 | 70247562 |
Pyrexia | 12.34 | 10.32 | 6155 | 668714 | 600797 | 69652778 |
Drug intolerance | 12.31 | 10.32 | 2381 | 672488 | 223306 | 70030269 |
Dysstasia | 12.31 | 10.32 | 167 | 674702 | 25012 | 70228563 |
Lymphopenia | 12.14 | 10.32 | 185 | 674684 | 27174 | 70226401 |
Inhibitory drug interaction | 12.11 | 10.32 | 11 | 674858 | 3796 | 70249779 |
Precancerous cells present | 12.11 | 10.32 | 30 | 674839 | 1067 | 70252508 |
Dermatitis allergic | 12.11 | 10.32 | 99 | 674770 | 16332 | 70237243 |
Inflammation | 12.11 | 10.32 | 887 | 673982 | 77778 | 70175797 |
Pulse absent | 12.10 | 10.32 | 139 | 674730 | 9191 | 70244384 |
Hypomania | 12.10 | 10.32 | 99 | 674770 | 5973 | 70247602 |
Infusion site haemorrhage | 12.09 | 10.32 | 56 | 674813 | 2759 | 70250816 |
Injection site discomfort | 12.09 | 10.32 | 16 | 674853 | 4653 | 70248922 |
Therapeutic response unexpected | 12.04 | 10.32 | 113 | 674756 | 18118 | 70235457 |
Tardive dyskinesia | 12.03 | 10.32 | 51 | 674818 | 9878 | 70243697 |
Allergy to chemicals | 11.96 | 10.32 | 44 | 674825 | 1952 | 70251623 |
Mycobacterium avium complex infection | 11.94 | 10.32 | 14 | 674855 | 4292 | 70249283 |
Withdrawal syndrome | 11.88 | 10.32 | 166 | 674703 | 24738 | 70228837 |
Hyperthyroidism | 11.83 | 10.32 | 128 | 674741 | 19963 | 70233612 |
Gait inability | 11.80 | 10.32 | 350 | 674519 | 46825 | 70206750 |
Acid-base balance disorder mixed | 11.78 | 10.32 | 9 | 674860 | 96 | 70253479 |
Sudden infant death syndrome | 11.75 | 10.32 | 12 | 674857 | 193 | 70253382 |
Prerenal failure | 11.74 | 10.32 | 9 | 674860 | 3377 | 70250198 |
Acute pulmonary oedema | 11.71 | 10.32 | 77 | 674792 | 13335 | 70240240 |
Hyperuricaemia | 11.70 | 10.32 | 59 | 674810 | 10907 | 70242668 |
Ankylosing spondylitis | 11.68 | 10.32 | 64 | 674805 | 11582 | 70241993 |
Sensation of foreign body | 11.65 | 10.32 | 82 | 674787 | 4720 | 70248855 |
Vascular rupture | 11.64 | 10.32 | 36 | 674833 | 1460 | 70252115 |
Seizure | 11.63 | 10.32 | 1499 | 673370 | 176463 | 70077112 |
Orthopnoea | 11.60 | 10.32 | 48 | 674821 | 9360 | 70244215 |
Muscular weakness | 11.54 | 10.32 | 1146 | 673723 | 137190 | 70116385 |
Atrioventricular block | 11.51 | 10.32 | 72 | 674797 | 12616 | 70240959 |
Pharyngitis streptococcal | 11.48 | 10.32 | 139 | 674730 | 9309 | 70244266 |
Pulmonary congestion | 11.43 | 10.32 | 317 | 674552 | 24837 | 70228738 |
Cutaneous T-cell lymphoma | 11.39 | 10.32 | 5 | 674864 | 2548 | 70251027 |
Lumbar vertebral fracture | 11.38 | 10.32 | 25 | 674844 | 5962 | 70247613 |
Vital functions abnormal | 11.37 | 10.32 | 22 | 674847 | 659 | 70252916 |
Consciousness fluctuating | 11.37 | 10.32 | 40 | 674829 | 1736 | 70251839 |
Temperature intolerance | 11.33 | 10.32 | 130 | 674739 | 8593 | 70244982 |
Affective disorder | 11.33 | 10.32 | 35 | 674834 | 7444 | 70246131 |
Cachexia | 11.30 | 10.32 | 52 | 674817 | 9848 | 70243727 |
Suspected COVID-19 | 11.29 | 10.32 | 49 | 674820 | 2347 | 70251228 |
Hypogammaglobulinaemia | 11.25 | 10.32 | 64 | 674805 | 11474 | 70242101 |
Atrioventricular block first degree | 11.25 | 10.32 | 65 | 674804 | 11608 | 70241967 |
Protein urine | 11.24 | 10.32 | 34 | 674835 | 1362 | 70252213 |
Complication of device insertion | 11.21 | 10.32 | 21 | 674848 | 5311 | 70248264 |
Latent tuberculosis | 11.20 | 10.32 | 8 | 674861 | 3113 | 70250462 |
Uterine perforation | 11.18 | 10.32 | 95 | 674774 | 5796 | 70247779 |
Device deployment issue | 11.16 | 10.32 | 7 | 674862 | 2917 | 70250658 |
Lupus-like syndrome | 11.16 | 10.32 | 64 | 674805 | 11451 | 70242124 |
Carpal tunnel syndrome | 11.14 | 10.32 | 106 | 674763 | 16951 | 70236624 |
Anti-erythrocyte antibody positive | 11.14 | 10.32 | 8 | 674861 | 77 | 70253498 |
Ventricular fibrillation | 11.13 | 10.32 | 186 | 674683 | 26925 | 70226650 |
Head discomfort | 11.12 | 10.32 | 180 | 674689 | 12843 | 70240732 |
Febrile infection | 11.12 | 10.32 | 8 | 674861 | 3101 | 70250474 |
Anoxia | 11.07 | 10.32 | 15 | 674854 | 330 | 70253245 |
Infective exacerbation of chronic obstructive airways disease | 11.07 | 10.32 | 5 | 674864 | 2506 | 70251069 |
Vessel puncture site bruise | 11.06 | 10.32 | 18 | 674851 | 469 | 70253106 |
Liver transplant | 11.03 | 10.32 | 74 | 674795 | 4192 | 70249383 |
Mucosal dryness | 11.00 | 10.32 | 60 | 674809 | 3156 | 70250419 |
Catheter management | 11 | 10.32 | 10 | 674859 | 3449 | 70250126 |
Burn of internal organs | 10.99 | 10.32 | 3 | 674866 | 0 | 70253575 |
Appendicolith | 10.99 | 10.32 | 92 | 674777 | 5588 | 70247987 |
Deep vein thrombosis | 10.99 | 10.32 | 908 | 673961 | 110134 | 70143441 |
Myocardial ischaemia | 10.95 | 10.32 | 163 | 674706 | 24037 | 70229538 |
Pulmonary embolism | 10.91 | 10.32 | 1307 | 673562 | 154560 | 70099015 |
Aortic valve stenosis | 10.90 | 10.32 | 19 | 674850 | 4940 | 70248635 |
Hepatitis E | 10.88 | 10.32 | 6 | 674863 | 2682 | 70250893 |
Infusion site warmth | 10.86 | 10.32 | 30 | 674839 | 1141 | 70252434 |
Treatment failure | 10.82 | 10.32 | 1203 | 673666 | 142939 | 70110636 |
Nervous system disorder | 10.80 | 10.32 | 163 | 674706 | 23983 | 70229592 |
Atrioventricular block second degree | 10.78 | 10.32 | 31 | 674838 | 6747 | 70246828 |
High density lipoprotein decreased | 10.78 | 10.32 | 14 | 674855 | 4105 | 70249470 |
Psychomotor skills impaired | 10.77 | 10.32 | 15 | 674854 | 4269 | 70249306 |
Dysgeusia | 10.76 | 10.32 | 374 | 674495 | 49128 | 70204447 |
Lip swelling | 10.76 | 10.32 | 411 | 674458 | 33643 | 70219932 |
Anaphylactoid reaction | 10.72 | 10.32 | 83 | 674786 | 4924 | 70248651 |
Red cell distribution width decreased | 10.69 | 10.32 | 37 | 674832 | 1592 | 70251983 |
Opiates positive | 10.69 | 10.32 | 26 | 674843 | 914 | 70252661 |
Brain scan abnormal | 10.68 | 10.32 | 30 | 674839 | 1152 | 70252423 |
Allergy to immunoglobulin therapy | 10.66 | 10.32 | 5 | 674864 | 19 | 70253556 |
Cerebellar syndrome | 10.65 | 10.32 | 21 | 674848 | 5210 | 70248365 |
Rheumatoid factor positive | 10.65 | 10.32 | 563 | 674306 | 47837 | 70205738 |
Neutropenic sepsis | 10.64 | 10.32 | 169 | 674700 | 24661 | 70228914 |
Ataxia | 10.64 | 10.32 | 156 | 674713 | 23061 | 70230514 |
Aortic valve incompetence | 10.63 | 10.32 | 46 | 674823 | 8858 | 70244717 |
Gastrointestinal perforation | 10.57 | 10.32 | 24 | 674845 | 5657 | 70247918 |
Complication associated with device | 10.54 | 10.32 | 97 | 674772 | 15616 | 70237959 |
Autoimmune haemolytic anaemia | 10.53 | 10.32 | 38 | 674831 | 7708 | 70245867 |
Administration site bruise | 10.53 | 10.32 | 9 | 674860 | 114 | 70253461 |
Psychotic symptom | 10.52 | 10.32 | 5 | 674864 | 2433 | 70251142 |
Intestinal obstruction | 10.48 | 10.32 | 285 | 674584 | 38540 | 70215035 |
Dissociation | 10.45 | 10.32 | 10 | 674859 | 3366 | 70250209 |
Ulcer | 10.45 | 10.32 | 320 | 674549 | 25434 | 70228141 |
Haemorrhagic stroke | 10.43 | 10.32 | 56 | 674813 | 10186 | 70243389 |
Upper respiratory tract infection | 10.42 | 10.32 | 883 | 673986 | 78391 | 70175184 |
White blood cell count decreased | 10.41 | 10.32 | 1439 | 673430 | 168702 | 70084873 |
Blood uric acid decreased | 10.40 | 10.32 | 30 | 674839 | 1170 | 70252405 |
Liver disorder | 10.40 | 10.32 | 479 | 674390 | 61089 | 70192486 |
Stent placement | 10.38 | 10.32 | 27 | 674842 | 6074 | 70247501 |
Cardiac dysfunction | 10.35 | 10.32 | 11 | 674858 | 3526 | 70250049 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Incorrect route of product administration | 22.41 | 20.24 | 6 | 364 | 7 | 89415 |
Source | Code | Description |
---|---|---|
ATC | D04AA32 | DERMATOLOGICALS ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. Antihistamines for topical use |
ATC | R06AA02 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Aminoalkyl ethers |
ATC | R06AA52 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Aminoalkyl ethers |
FDA MoA | N0000000190 | Histamine H1 Receptor Antagonists |
FDA EPC | N0000175587 | Histamine-1 Receptor Antagonist |
CHEBI has role | CHEBI:35717 | hypnotics |
CHEBI has role | CHEBI:36333 | local anesthetics |
CHEBI has role | CHEBI:37955 | H1 receptor antagonists |
CHEBI has role | CHEBI:48407 | antiparkinson agent |
CHEBI has role | CHEBI:48876 | muscarinic antagonists |
CHEBI has role | CHEBI:50857 | anti-allergic drugs |
CHEBI has role | CHEBI:50919 | antiemetico |
CHEBI has role | CHEBI:51177 | anti-tussive |
CHEBI has role | CHEBI:59683 | antipruritic drugs |
CHEBI has role | CHEBI:66956 | antidyskinetic agent |
CHEBI has role | CHEBI:146270 | oneirogens |
MeSH PA | D000777 | Anesthetics |
MeSH PA | D000779 | Anesthetics, Local |
MeSH PA | D018926 | Anti-Allergic Agents |
MeSH PA | D000932 | Antiemetics |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D018494 | Histamine Agents |
MeSH PA | D006633 | Histamine Antagonists |
MeSH PA | D006634 | Histamine H1 Antagonists |
MeSH PA | D006993 | Hypnotics and Sedatives |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
MeSH PA | D000068776 | Sleep Aids, Pharmaceutical |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Vasomotor rhinitis | indication | 8229003 | DOID:4730 |
Insomnia | indication | 193462001 | |
Seasonal allergic rhinitis | indication | 367498001 | |
Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
Migraine | off-label use | 37796009 | DOID:6364 |
Anxiety disorder | off-label use | 197480006 | DOID:2030 |
Local anesthesia | off-label use | 386761002 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.52 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
25MG;EQ 200MG FREE ACID AND POTASSIUM SALT | ADVIL PM | GLAXOSMITHKLINE | N021393 | Dec. 21, 2005 | OTC | CAPSULE | ORAL | 8883849 | Jan. 17, 2022 | A METHOD OF TREATING A PATIENT SUFFERING FROM A PAIN ASSOCIATED SLEEP DISTURBANCE COMPRISING ADMINISTERING A LIQUID COMPOSITION FORMULATED INSIDE A SOFT GEL CAPSULE, AS CLAIMED, TO THE PATIENT |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Histamine H1 receptor | GPCR | ANTAGONIST | Ki | 7.81 | WOMBAT-PK | CHEMBL | |||
Sodium-dependent noradrenaline transporter | Transporter | Kd | 6.02 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 6.43 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 6.15 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 6.29 | DRUG MATRIX | |||||
Histamine H4 receptor | GPCR | Ki | 4.37 | CHEMBL | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 7 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M2 | GPCR | Ki | 6.92 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M3 | GPCR | Ki | 6.64 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M4 | GPCR | Ki | 6.95 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M5 | GPCR | Ki | 6.59 | WOMBAT-PK | |||||
Cytochrome P450 2D6 | Enzyme | Ki | 4.93 | WOMBAT-PK | |||||
Solute carrier family 22 member 2 | Transporter | IC50 | 4.68 | WOMBAT-PK | |||||
Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 5.22 | CHEMBL | |||||
Sodium-dependent serotonin transporter | Transporter | Kd | 5.42 | SCIENTIFIC LITERATURE | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.59 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Kd | 5.66 | SCIENTIFIC LITERATURE | |||||
Histamine H1 receptor | GPCR | IC50 | 9 | CHEMBL |
ID | Source |
---|---|
4019724 | VUID |
N0000147816 | NUI |
D00300 | KEGG_DRUG |
7491-10-3 | SECONDARY_CAS_RN |
103659-13-8 | SECONDARY_CAS_RN |
147-24-0 | SECONDARY_CAS_RN |
88637-37-0 | SECONDARY_CAS_RN |
1362 | RXNORM |
4017866 | VANDF |
4019724 | VANDF |
4020653 | VANDF |
C0012522 | UMLSCUI |
CHEBI:4636 | CHEBI |
2PM | PDB_CHEM_ID |
CHEMBL657 | ChEMBL_ID |
CHEMBL1201089 | ChEMBL_ID |
CHEMBL1620 | ChEMBL_ID |
DB01075 | DRUGBANK_ID |
D004155 | MESH_DESCRIPTOR_UI |
3100 | PUBCHEM_CID |
1224 | IUPHAR_LIGAND_ID |
1774 | INN_ID |
8GTS82S83M | UNII |
1676 | MMSL |
4611 | MMSL |
4612 | MMSL |
899 | MMSL |
d00212 | MMSL |
003369 | NDDF |
004787 | NDDF |
005115 | NDDF |
19510001 | SNOMEDCT_US |
26458009 | SNOMEDCT_US |
372682005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Childrens Dimetapp Multi-Symptom Cold and Flu | HUMAN OTC DRUG LABEL | 3 | 0031-2249 | LIQUID | 12.50 mg | ORAL | Unapproved drug other | 17 sections |
Robitussin Severe Multi-Symptom Cough Cold Flu Nighttime | HUMAN OTC DRUG LABEL | 3 | 0031-8752 | SOLUTION | 25 mg | ORAL | OTC monograph final | 17 sections |
Robitussin Severe Multi-Symptom Cough Cold Flu Nighttime | HUMAN OTC DRUG LABEL | 3 | 0031-8752 | SOLUTION | 25 mg | ORAL | OTC monograph final | 17 sections |
Robitussin Honey Severe Cough, Flu Plus Sore Throat Nighttime | HUMAN OTC DRUG LABEL | 2 | 0031-8770 | SOLUTION | 25 mg | ORAL | OTC MONOGRAPH FINAL | 17 sections |
Robitussin Direct Runny Nose | HUMAN OTC DRUG LABEL | 1 | 0031-9304 | TABLET, COATED | 25 mg | ORAL | OTC monograph final | 16 sections |
Excedrin PM Triple Action Caplets | HUMAN OTC DRUG LABEL | 3 | 0067-2056 | TABLET, COATED | 38 mg | ORAL | OTC monograph not final | 16 sections |
Excedrin PM Triple Action Caplets | HUMAN OTC DRUG LABEL | 3 | 0067-2056 | TABLET, COATED | 38 mg | ORAL | OTC monograph not final | 16 sections |
THERAFLUPOWERPODS NIGHTTIME SEVERE COLD | HUMAN OTC DRUG LABEL | 3 | 0067-6095 | POWDER, FOR SOLUTION | 25 mg | ORAL | OTC monograph final | 16 sections |
THERAFLUNIGHTTIME SEVERE COLD AND COUGH | HUMAN OTC DRUG LABEL | 3 | 0067-7918 | POWDER, FOR SOLUTION | 25 mg | ORAL | OTC monograph final | 17 sections |
TRIAMINICNight Time Cold and Cough | HUMAN OTC DRUG LABEL | 2 | 0067-8106 | SYRUP | 6.25 mg | ORAL | OTC monograph final | 15 sections |
Theraflu Nighttime Multi-Symptom Severe Cold Powder | HUMAN OTC DRUG LABEL | 3 | 0067-8124 | POWDER | 25 mg | ORAL | OTC monograph final | 16 sections |
Theraflu ExpressMaxNighttime Severe Cold and Cough | HUMAN OTC DRUG LABEL | 3 | 0067-8129 | SYRUP | 25 mg | ORAL | OTC monograph final | 16 sections |
Theraflu ExpressMaxNighttime Severe Cold and Cough | HUMAN OTC DRUG LABEL | 3 | 0067-8129 | SYRUP | 25 mg | ORAL | OTC monograph final | 16 sections |
Theraflu ExpressMaxNighttime Severe Cold and Cough | HUMAN OTC DRUG LABEL | 3 | 0067-8137 | TABLET, FILM COATED | 12.50 mg | ORAL | OTC monograph final | 16 sections |
good sense ibuprofen pm | HUMAN OTC DRUG LABEL | 2 | 0113-0050 | TABLET, FILM COATED | 38 mg | ORAL | ANDA | 16 sections |
good sense sleep time | HUMAN OTC DRUG LABEL | 1 | 0113-0052 | CAPSULE, LIQUID FILLED | 25 mg | ORAL | OTC monograph final | 16 sections |
Good Sense Sleep Time | HUMAN OTC DRUG LABEL | 1 | 0113-0186 | SOLUTION | 50 mg | ORAL | OTC monograph final | 16 sections |
Good Sense Sleep Time | HUMAN OTC DRUG LABEL | 1 | 0113-0186 | SOLUTION | 50 mg | ORAL | OTC monograph final | 16 sections |
good sense allergy | HUMAN OTC DRUG LABEL | 1 | 0113-0379 | SOLUTION | 12.50 mg | ORAL | OTC monograph final | 14 sections |
good sense nighttime sleep aid | HUMAN OTC DRUG LABEL | 1 | 0113-0431 | TABLET, FILM COATED | 25 mg | ORAL | OTC monograph final | 16 sections |
good sense pain relief pmextra strength | HUMAN OTC DRUG LABEL | 2 | 0113-0437 | TABLET, FILM COATED | 25 mg | ORAL | OTC monograph not final | 16 sections |
Good Sense Allergy Relief | HUMAN OTC DRUG LABEL | 1 | 0113-0462 | CAPSULE | 25 mg | ORAL | OTC monograph final | 15 sections |
good sense allergy relief | HUMAN OTC DRUG LABEL | 1 | 0113-0479 | TABLET | 25 mg | ORAL | OTC monograph final | 15 sections |
good sense itch relief | HUMAN OTC DRUG LABEL | 2 | 0113-0622 | CREAM | 2 g | TOPICAL | OTC monograph not final | 14 sections |
Childrens Night Time Cold and Cough | HUMAN OTC DRUG LABEL | 2 | 0113-0808 | SOLUTION | 6.25 mg | ORAL | OTC monograph final | 15 sections |
Good Sense Pain Relief PMExtra Strength | HUMAN OTC DRUG LABEL | 2 | 0113-0837 | TABLET, COATED | 25 mg | ORAL | OTC monograph not final | 15 sections |
good sense flu and severe cold and coughnighttime | HUMAN OTC DRUG LABEL | 3 | 0113-0964 | POWDER, FOR SOLUTION | 25 mg | ORAL | OTC monograph final | 16 sections |
good sense sleep aid | HUMAN OTC DRUG LABEL | 1 | 0113-1909 | CAPSULE, LIQUID FILLED | 50 mg | ORAL | OTC monograph final | 16 sections |
basic care nighttime sleep aid | HUMAN OTC DRUG LABEL | 1 | 0113-7186 | SOLUTION | 50 mg | ORAL | OTC monograph final | 16 sections |
basic care naproxen sodium pm | HUMAN OTC DRUG LABEL | 2 | 0113-7264 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 16 sections |