Stem definition | Drug id | CAS RN |
---|---|---|
anorexics | 841 | 51-64-9 |
Dose | Unit | Route |
---|---|---|
15 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 0 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 1 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 40 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 7.40 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 75 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 9, 1955 | FDA | UCB INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pre-existing condition improved | 248.91 | 13.94 | 103 | 24642 | 6509 | 46654808 |
Prescribed overdose | 242.65 | 13.94 | 116 | 24629 | 10333 | 46650984 |
Anxiety | 210.71 | 13.94 | 359 | 24386 | 181598 | 46479719 |
Product substitution issue | 189.58 | 13.94 | 111 | 24634 | 14920 | 46646397 |
Depression | 179.15 | 13.94 | 322 | 24423 | 169782 | 46491535 |
Suicidal ideation | 161.08 | 13.94 | 173 | 24572 | 56209 | 46605108 |
Feeling abnormal | 148.84 | 13.94 | 250 | 24495 | 124810 | 46536507 |
Migraine | 129.24 | 13.94 | 172 | 24573 | 69854 | 46591463 |
Sleep apnoea syndrome | 125.91 | 13.94 | 100 | 24645 | 22101 | 46639216 |
Product physical issue | 121.41 | 13.94 | 57 | 24688 | 4870 | 46656447 |
Product quality issue | 115.42 | 13.94 | 117 | 24628 | 35531 | 46625786 |
Drug ineffective | 106.27 | 13.94 | 666 | 24079 | 677172 | 45984145 |
Disturbance in attention | 104.76 | 13.94 | 105 | 24640 | 31455 | 46629862 |
Therapeutic response unexpected | 100.88 | 13.94 | 76 | 24669 | 15540 | 46645777 |
Somnolence | 85.89 | 13.94 | 228 | 24517 | 156293 | 46505024 |
Cataplexy | 79.48 | 13.94 | 28 | 24717 | 1135 | 46660182 |
Inappropriate schedule of product administration | 70.69 | 13.94 | 125 | 24620 | 64888 | 46596429 |
Irritability | 69.20 | 13.94 | 81 | 24664 | 28865 | 46632452 |
Neutropenia | 63.32 | 13.94 | 3 | 24742 | 143201 | 46518116 |
Somnambulism | 62.96 | 13.94 | 37 | 24708 | 5000 | 46656317 |
Headache | 61.93 | 13.94 | 449 | 24296 | 477903 | 46183414 |
Coronary artery dissection | 60.41 | 13.94 | 20 | 24725 | 670 | 46660647 |
Surgery | 58.18 | 13.94 | 74 | 24671 | 28711 | 46632606 |
Multiple sclerosis relapse | 57.88 | 13.94 | 90 | 24655 | 42035 | 46619282 |
Panic attack | 57.54 | 13.94 | 62 | 24683 | 20180 | 46641137 |
Anaemia | 56.16 | 13.94 | 33 | 24712 | 255746 | 46405571 |
Death | 47.68 | 13.94 | 65 | 24680 | 335483 | 46325834 |
Device expulsion | 45.24 | 13.94 | 64 | 24681 | 27478 | 46633839 |
Anger | 44.11 | 13.94 | 42 | 24703 | 11810 | 46649507 |
Asthma exercise induced | 44.06 | 13.94 | 11 | 24734 | 129 | 46661188 |
Memory impairment | 42.68 | 13.94 | 113 | 24632 | 77224 | 46584093 |
Snoring | 42.28 | 13.94 | 25 | 24720 | 3417 | 46657900 |
Complication of device insertion | 40.96 | 13.94 | 28 | 24717 | 4916 | 46656401 |
Hyponatraemia | 39.37 | 13.94 | 4 | 24741 | 101328 | 46559989 |
Febrile neutropenia | 38.75 | 13.94 | 3 | 24742 | 94624 | 46566693 |
Product dose omission issue | 38.48 | 13.94 | 184 | 24561 | 168336 | 46492981 |
Pyrexia | 38.09 | 13.94 | 80 | 24665 | 348722 | 46312595 |
Stress | 37.73 | 13.94 | 84 | 24661 | 51467 | 46609850 |
Acute kidney injury | 37.34 | 13.94 | 42 | 24703 | 235813 | 46425504 |
Hunger | 37.06 | 13.94 | 24 | 24721 | 3851 | 46657466 |
Compartment syndrome | 36.91 | 13.94 | 19 | 24726 | 1980 | 46659337 |
Tremor | 36.23 | 13.94 | 139 | 24606 | 115500 | 46545817 |
Attention deficit hyperactivity disorder | 35.43 | 13.94 | 19 | 24726 | 2153 | 46659164 |
Rheumatoid arthritis | 34.62 | 13.94 | 46 | 24699 | 240169 | 46421148 |
Thrombocytopenia | 34.50 | 13.94 | 12 | 24733 | 126569 | 46534748 |
Pancytopenia | 33.99 | 13.94 | 3 | 24742 | 85055 | 46576262 |
Abnormal sleep-related event | 32.79 | 13.94 | 13 | 24732 | 734 | 46660583 |
Stress cardiomyopathy | 31.69 | 13.94 | 29 | 24716 | 7755 | 46653562 |
Completed suicide | 31.63 | 13.94 | 157 | 24588 | 145763 | 46515554 |
Insomnia | 31.30 | 13.94 | 171 | 24574 | 164753 | 46496564 |
Drug tolerance | 30.95 | 13.94 | 20 | 24725 | 3198 | 46658119 |
Oedema peripheral | 30.47 | 13.94 | 24 | 24721 | 159682 | 46501635 |
Post-traumatic stress disorder | 29.06 | 13.94 | 21 | 24724 | 4027 | 46657290 |
Cardiac failure | 28.96 | 13.94 | 4 | 24741 | 79944 | 46581373 |
Tachyphrenia | 28.92 | 13.94 | 14 | 24731 | 1280 | 46660037 |
No adverse event | 28.75 | 13.94 | 59 | 24686 | 34172 | 46627145 |
Renal impairment | 28.72 | 13.94 | 3 | 24742 | 74369 | 46586948 |
Enuresis | 28.49 | 13.94 | 16 | 24729 | 1984 | 46659333 |
Extra dose administered | 28.39 | 13.94 | 22 | 24723 | 4685 | 46656632 |
Serotonin syndrome | 28.17 | 13.94 | 48 | 24697 | 24172 | 46637145 |
Unevaluable event | 28.08 | 13.94 | 70 | 24675 | 46105 | 46615212 |
Product tampering | 27.89 | 13.94 | 7 | 24738 | 84 | 46661233 |
Suspected product quality issue | 27.57 | 13.94 | 8 | 24737 | 171 | 46661146 |
Illness | 27.22 | 13.94 | 33 | 24712 | 12191 | 46649126 |
Mood altered | 27.16 | 13.94 | 34 | 24711 | 12973 | 46648344 |
Sleep paralysis | 27.16 | 13.94 | 10 | 24735 | 461 | 46660856 |
Wrong technique in product usage process | 26.52 | 13.94 | 76 | 24669 | 54346 | 46606971 |
Device dislocation | 26.41 | 13.94 | 44 | 24701 | 21758 | 46639559 |
Diarrhoea | 25.99 | 13.94 | 182 | 24563 | 559420 | 46101897 |
Hangover | 25.93 | 13.94 | 13 | 24732 | 1282 | 46660035 |
Bipolar disorder | 25.88 | 13.94 | 25 | 24720 | 7152 | 46654165 |
Feeling drunk | 25.28 | 13.94 | 19 | 24726 | 3868 | 46657449 |
General physical health deterioration | 25.27 | 13.94 | 15 | 24730 | 115754 | 46545563 |
Pneumonia | 24.76 | 13.94 | 109 | 24636 | 376211 | 46285106 |
Cardiac failure congestive | 24.48 | 13.94 | 9 | 24736 | 91741 | 46569576 |
Drug diversion | 24.47 | 13.94 | 11 | 24734 | 850 | 46660467 |
Nephrolithiasis | 24.34 | 13.94 | 54 | 24691 | 32997 | 46628320 |
Paranoia | 24.23 | 13.94 | 29 | 24716 | 10568 | 46650749 |
Oxygen saturation decreased | 23.82 | 13.94 | 4 | 24741 | 69160 | 46592157 |
Haemoglobin decreased | 23.82 | 13.94 | 20 | 24725 | 128929 | 46532388 |
Agitation | 23.79 | 13.94 | 74 | 24671 | 55341 | 46605976 |
Multiple sclerosis | 23.56 | 13.94 | 45 | 24700 | 24746 | 46636571 |
Dry mouth | 23.26 | 13.94 | 73 | 24672 | 54853 | 46606464 |
Weight decreased | 23.25 | 13.94 | 191 | 24554 | 210658 | 46450659 |
Atrial fibrillation | 23.21 | 13.94 | 13 | 24732 | 103577 | 46557740 |
Therapeutic response changed | 22.75 | 13.94 | 10 | 24735 | 732 | 46660585 |
Thinking abnormal | 22.68 | 13.94 | 27 | 24718 | 9787 | 46651530 |
Product preparation error | 22.47 | 13.94 | 18 | 24727 | 4021 | 46657296 |
Uterine perforation | 21.96 | 13.94 | 23 | 24722 | 7244 | 46654073 |
Joint swelling | 21.74 | 13.94 | 34 | 24711 | 166039 | 46495278 |
Dyspnoea | 21.38 | 13.94 | 173 | 24572 | 515375 | 46145942 |
Mood swings | 21.31 | 13.94 | 34 | 24711 | 16218 | 46645099 |
Intentional product use issue | 21.30 | 13.94 | 69 | 24676 | 52711 | 46608606 |
Drug interaction | 20.95 | 13.94 | 48 | 24697 | 203046 | 46458271 |
Initial insomnia | 20.94 | 13.94 | 18 | 24727 | 4434 | 46656883 |
Postural orthostatic tachycardia syndrome | 20.61 | 13.94 | 9 | 24736 | 649 | 46660668 |
Hypnagogic hallucination | 20.60 | 13.94 | 6 | 24739 | 130 | 46661187 |
Platelet count decreased | 20.41 | 13.94 | 14 | 24731 | 100010 | 46561307 |
Complication of device removal | 20.37 | 13.94 | 16 | 24729 | 3474 | 46657843 |
Disability | 20.32 | 13.94 | 26 | 24719 | 10141 | 46651176 |
Feeling jittery | 20.21 | 13.94 | 27 | 24718 | 10981 | 46650336 |
Bruxism | 20.18 | 13.94 | 15 | 24730 | 3002 | 46658315 |
Aggression | 20.05 | 13.94 | 40 | 24705 | 22704 | 46638613 |
Acne | 19.97 | 13.94 | 37 | 24708 | 19882 | 46641435 |
Seizure like phenomena | 19.95 | 13.94 | 10 | 24735 | 985 | 46660332 |
Muscle twitching | 19.66 | 13.94 | 31 | 24714 | 14641 | 46646676 |
Crying | 19.63 | 13.94 | 38 | 24707 | 21103 | 46640214 |
Infusion related reaction | 19.56 | 13.94 | 15 | 24730 | 101193 | 46560124 |
Blood creatinine increased | 19.54 | 13.94 | 8 | 24737 | 76395 | 46584922 |
Renal failure | 19.33 | 13.94 | 19 | 24726 | 113575 | 46547742 |
Pleural effusion | 19.18 | 13.94 | 10 | 24735 | 82942 | 46578375 |
Victim of crime | 18.89 | 13.94 | 5 | 24740 | 75 | 46661242 |
Shoulder operation | 18.81 | 13.94 | 12 | 24733 | 1876 | 46659441 |
Suicide attempt | 18.75 | 13.94 | 68 | 24677 | 54968 | 46606349 |
Hypotension | 18.74 | 13.94 | 62 | 24683 | 232527 | 46428790 |
Muscle spasms | 18.42 | 13.94 | 120 | 24625 | 122993 | 46538324 |
Embedded device | 18.40 | 13.94 | 14 | 24731 | 2902 | 46658415 |
Gastrointestinal haemorrhage | 18.38 | 13.94 | 9 | 24736 | 77364 | 46583953 |
Disease progression | 18.33 | 13.94 | 13 | 24732 | 91287 | 46570030 |
Victim of abuse | 18.20 | 13.94 | 5 | 24740 | 87 | 46661230 |
Weight increased | 18.12 | 13.94 | 149 | 24596 | 164324 | 46496993 |
Condition aggravated | 18.10 | 13.94 | 204 | 24541 | 244848 | 46416469 |
Tic | 17.91 | 13.94 | 10 | 24735 | 1226 | 46660091 |
Road traffic accident | 17.77 | 13.94 | 39 | 24706 | 23652 | 46637665 |
Treatment failure | 17.73 | 13.94 | 14 | 24731 | 93073 | 46568244 |
Sepsis | 17.65 | 13.94 | 28 | 24717 | 135986 | 46525331 |
Change in sustained attention | 17.55 | 13.94 | 3 | 24742 | 3 | 46661314 |
Colitis ischaemic | 17.31 | 13.94 | 24 | 24721 | 10108 | 46651209 |
Injury | 17.26 | 13.94 | 57 | 24688 | 43970 | 46617347 |
Lower respiratory tract infection | 17.26 | 13.94 | 4 | 24741 | 55085 | 46606232 |
Hysterectomy | 17.26 | 13.94 | 21 | 24724 | 7785 | 46653532 |
Hyperhidrosis | 17.18 | 13.94 | 93 | 24652 | 89215 | 46572102 |
Respiratory failure | 17.14 | 13.94 | 15 | 24730 | 94801 | 46566516 |
Substance use | 17.12 | 13.94 | 7 | 24738 | 428 | 46660889 |
Myocardial infarction | 16.96 | 13.94 | 16 | 24729 | 97512 | 46563805 |
Depressed mood | 16.68 | 13.94 | 47 | 24698 | 33272 | 46628045 |
Arthralgia | 16.66 | 13.94 | 119 | 24626 | 364484 | 46296833 |
Device breakage | 16.62 | 13.94 | 23 | 24722 | 9669 | 46651648 |
Educational problem | 16.28 | 13.94 | 6 | 24739 | 277 | 46661040 |
Libido increased | 16.20 | 13.94 | 8 | 24737 | 764 | 46660553 |
Leukopenia | 16.16 | 13.94 | 8 | 24737 | 68335 | 46592982 |
Withdrawal syndrome | 16.11 | 13.94 | 32 | 24713 | 18102 | 46643215 |
Drug withdrawal syndrome | 16.10 | 13.94 | 41 | 24704 | 27343 | 46633974 |
Narcolepsy | 15.78 | 13.94 | 9 | 24736 | 1150 | 46660167 |
Drug intolerance | 15.77 | 13.94 | 34 | 24711 | 147015 | 46514302 |
Multiple organ dysfunction syndrome | 15.72 | 13.94 | 4 | 24741 | 51706 | 46609611 |
Blood testosterone increased | 15.69 | 13.94 | 5 | 24740 | 148 | 46661169 |
White blood cell count decreased | 15.63 | 13.94 | 22 | 24723 | 112209 | 46549108 |
Pulmonary oedema | 15.45 | 13.94 | 4 | 24741 | 51101 | 46610216 |
Dermatillomania | 15.11 | 13.94 | 5 | 24740 | 167 | 46661150 |
Therapeutic response shortened | 14.90 | 13.94 | 16 | 24729 | 5183 | 46656134 |
Interstitial lung disease | 14.89 | 13.94 | 5 | 24740 | 53944 | 46607373 |
Alcoholism | 14.78 | 13.94 | 11 | 24734 | 2207 | 46659110 |
Dysphoria | 14.72 | 13.94 | 15 | 24730 | 4574 | 46656743 |
Victim of spousal abuse | 14.43 | 13.94 | 3 | 24742 | 14 | 46661303 |
Overdose | 14.40 | 13.94 | 98 | 24647 | 101881 | 46559436 |
Dyspareunia | 14.23 | 13.94 | 11 | 24734 | 2333 | 46658984 |
Fatigue | 14.14 | 13.94 | 422 | 24323 | 608275 | 46053042 |
Breast atrophy | 14.10 | 13.94 | 3 | 24742 | 16 | 46661301 |
Parasomnia | 14.06 | 13.94 | 6 | 24739 | 409 | 46660908 |
Therapeutic product effect increased | 14.03 | 13.94 | 8 | 24737 | 1022 | 46660295 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Product substitution issue | 217.25 | 18.26 | 95 | 10968 | 9940 | 29931475 |
Drug ineffective | 200.49 | 18.26 | 407 | 10656 | 339980 | 29601435 |
Anxiety | 148.36 | 18.26 | 174 | 10889 | 89697 | 29851718 |
Prescribed overdose | 147.08 | 18.26 | 69 | 10994 | 8492 | 29932923 |
Suicidal ideation | 131.62 | 18.26 | 108 | 10955 | 36006 | 29905409 |
Aggression | 115.25 | 18.26 | 101 | 10962 | 36806 | 29904609 |
Product quality issue | 113.12 | 18.26 | 76 | 10987 | 18698 | 29922717 |
Feeling abnormal | 110.78 | 18.26 | 120 | 10943 | 56636 | 29884779 |
Depression | 109.32 | 18.26 | 150 | 10913 | 90287 | 29851128 |
Irritability | 107.98 | 18.26 | 80 | 10983 | 22970 | 29918445 |
Crying | 83.53 | 18.26 | 41 | 11022 | 5568 | 29935847 |
Oppositional defiant disorder | 83.16 | 18.26 | 21 | 11042 | 381 | 29941034 |
Insomnia | 81.49 | 18.26 | 133 | 10930 | 93203 | 29848212 |
Product physical issue | 79.46 | 18.26 | 30 | 11033 | 2144 | 29939271 |
Sleep apnoea syndrome | 77.79 | 18.26 | 58 | 11005 | 16799 | 29924616 |
Decreased eye contact | 76.66 | 18.26 | 20 | 11043 | 415 | 29941000 |
Impulsive behaviour | 71.40 | 18.26 | 27 | 11036 | 1938 | 29939477 |
Bruxism | 69.34 | 18.26 | 24 | 11039 | 1335 | 29940080 |
Anger | 69.32 | 18.26 | 46 | 11017 | 11074 | 29930341 |
Abnormal behaviour | 66.02 | 18.26 | 63 | 11000 | 25560 | 29915855 |
Tic | 63.42 | 18.26 | 25 | 11038 | 2007 | 29939408 |
Homicidal ideation | 58.77 | 18.26 | 25 | 11038 | 2438 | 29938977 |
Disturbance in attention | 58.13 | 18.26 | 55 | 11008 | 22074 | 29919341 |
Psychomotor hyperactivity | 56.10 | 18.26 | 36 | 11027 | 8188 | 29933227 |
Somnolence | 54.25 | 18.26 | 114 | 10949 | 96649 | 29844766 |
Psychotic disorder | 51.84 | 18.26 | 51 | 11012 | 21464 | 29919951 |
Educational problem | 48.27 | 18.26 | 13 | 11050 | 306 | 29941109 |
Affect lability | 47.97 | 18.26 | 24 | 11039 | 3394 | 29938021 |
Depressed mood | 47.95 | 18.26 | 44 | 11019 | 16985 | 29924430 |
Coordination abnormal | 47.42 | 18.26 | 31 | 11032 | 7274 | 29934141 |
Acute kidney injury | 45.87 | 18.26 | 22 | 11041 | 273820 | 29667595 |
Poor quality sleep | 45.23 | 18.26 | 30 | 11033 | 7211 | 29934204 |
Mood altered | 44.00 | 18.26 | 31 | 11032 | 8219 | 29933196 |
Pre-existing condition improved | 43.44 | 18.26 | 19 | 11044 | 1982 | 29939433 |
Pneumonia | 42.23 | 18.26 | 37 | 11026 | 334269 | 29607146 |
Anaemia | 40.91 | 18.26 | 13 | 11050 | 207979 | 29733436 |
Therapeutic response unexpected | 39.65 | 18.26 | 30 | 11033 | 8873 | 29932542 |
No adverse event | 39.58 | 18.26 | 40 | 11023 | 17379 | 29924036 |
Choreoathetosis | 38.07 | 18.26 | 14 | 11049 | 929 | 29940486 |
Completed suicide | 38.05 | 18.26 | 101 | 10962 | 99391 | 29842024 |
Inappropriate schedule of product administration | 37.86 | 18.26 | 59 | 11004 | 39669 | 29901746 |
Therapeutic product effect decreased | 37.72 | 18.26 | 50 | 11013 | 29026 | 29912389 |
Electrocardiogram QRS complex prolonged | 37.54 | 18.26 | 22 | 11041 | 4255 | 29937160 |
Migraine | 35.72 | 18.26 | 33 | 11030 | 12841 | 29928574 |
Somnambulism | 34.89 | 18.26 | 19 | 11044 | 3195 | 29938220 |
Restless legs syndrome | 34.75 | 18.26 | 25 | 11038 | 6847 | 29934568 |
Death | 33.75 | 18.26 | 50 | 11013 | 357233 | 29584182 |
Disturbance in social behaviour | 32.04 | 18.26 | 14 | 11049 | 1457 | 29939958 |
Agitation | 31.77 | 18.26 | 65 | 10998 | 54008 | 29887407 |
Trismus | 31.41 | 18.26 | 16 | 11047 | 2349 | 29939066 |
Intentional overdose | 29.42 | 18.26 | 54 | 11009 | 41427 | 29899988 |
Emotional disorder | 29.17 | 18.26 | 20 | 11043 | 5074 | 29936341 |
Thyrotoxic crisis | 28.88 | 18.26 | 9 | 11054 | 359 | 29941056 |
Headache | 28.59 | 18.26 | 138 | 10925 | 182168 | 29759247 |
Sleep disorder | 28.57 | 18.26 | 40 | 11023 | 24439 | 29916976 |
Incorrect route of product administration | 27.58 | 18.26 | 27 | 11036 | 11288 | 29930127 |
Speech disorder | 27.05 | 18.26 | 39 | 11024 | 24473 | 29916942 |
Substance use | 26.94 | 18.26 | 9 | 11054 | 449 | 29940966 |
Weight increased | 26.56 | 18.26 | 74 | 10989 | 74839 | 29866576 |
Sleep-related eating disorder | 26.35 | 18.26 | 8 | 11055 | 292 | 29941123 |
Febrile neutropenia | 26.31 | 18.26 | 4 | 11059 | 106689 | 29834726 |
Attention deficit hyperactivity disorder | 26.16 | 18.26 | 13 | 11050 | 1811 | 29939604 |
Muscle necrosis | 25.71 | 18.26 | 10 | 11053 | 774 | 29940641 |
Sepsis | 25.64 | 18.26 | 11 | 11052 | 146384 | 29795031 |
Product dose omission issue | 25.41 | 18.26 | 83 | 10980 | 91548 | 29849867 |
Neutropenia | 25.30 | 18.26 | 8 | 11055 | 128532 | 29812883 |
Fatigue | 25.14 | 18.26 | 203 | 10860 | 320470 | 29620945 |
Therapeutic response shortened | 25.14 | 18.26 | 16 | 11047 | 3584 | 29937831 |
Cataplexy | 24.63 | 18.26 | 8 | 11055 | 365 | 29941050 |
Post-traumatic stress disorder | 24.62 | 18.26 | 12 | 11051 | 1603 | 29939812 |
Unevaluable event | 24.61 | 18.26 | 43 | 11020 | 31742 | 29909673 |
Paranoia | 24.25 | 18.26 | 24 | 11039 | 10164 | 29931251 |
Pyrexia | 24.24 | 18.26 | 45 | 11018 | 294444 | 29646971 |
Renal failure | 23.71 | 18.26 | 9 | 11054 | 128957 | 29812458 |
Memory impairment | 22.19 | 18.26 | 45 | 11018 | 37129 | 29904286 |
Hypotension | 22.03 | 18.26 | 25 | 11038 | 200540 | 29740875 |
Sexual dysfunction | 21.93 | 18.26 | 18 | 11045 | 5983 | 29935432 |
Drug abuse | 21.55 | 18.26 | 73 | 10990 | 81999 | 29859416 |
Streptococcal infection | 21.26 | 18.26 | 16 | 11047 | 4692 | 29936723 |
Renal impairment | 21.11 | 18.26 | 3 | 11060 | 84181 | 29857234 |
Amphetamines positive | 20.94 | 18.26 | 5 | 11058 | 71 | 29941344 |
Enuresis | 20.69 | 18.26 | 11 | 11052 | 1763 | 29939652 |
Mood swings | 20.10 | 18.26 | 19 | 11044 | 7607 | 29933808 |
Dystonia | 19.68 | 18.26 | 21 | 11042 | 9706 | 29931709 |
Intentional product misuse | 19.56 | 18.26 | 41 | 11022 | 34626 | 29906789 |
Libido decreased | 19.48 | 18.26 | 15 | 11048 | 4551 | 29936864 |
Supraventricular extrasystoles | 19.20 | 18.26 | 13 | 11050 | 3231 | 29938184 |
Hyperkinesia | 18.96 | 18.26 | 11 | 11052 | 2087 | 29939328 |
Wrong technique in product usage process | 18.93 | 18.26 | 38 | 11025 | 31117 | 29910298 |
Hyperhidrosis | 18.79 | 18.26 | 61 | 11002 | 67029 | 29874386 |
Seizure | 18.73 | 18.26 | 79 | 10984 | 98396 | 29843019 |
Gastrointestinal haemorrhage | 18.69 | 18.26 | 4 | 11059 | 83442 | 29857973 |
Thrombocytopenia | 18.69 | 18.26 | 14 | 11049 | 137030 | 29804385 |
Platelet count decreased | 18.53 | 18.26 | 8 | 11055 | 106121 | 29835294 |
Hypertensive emergency | 18.28 | 18.26 | 8 | 11055 | 836 | 29940579 |
Source | Code | Description |
---|---|---|
ATC | N06BA02 | NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS Centrally acting sympathomimetics |
FDA PE | N0000175729 | Central Nervous System Stimulation |
FDA EPC | N0000175739 | Central Nervous System Stimulant |
CHEBI has role | CHEBI:35524 | sympathomimetic |
CHEBI has role | CHEBI:35640 | adrenergic uptake inhibitors |
CHEBI has role | CHEBI:37962 | adrenergic neuron agents |
CHEBI has role | CHEBI:48560 | dopamine agents |
CHEBI has role | CHEBI:50910 | agente neurotoxico |
CHEBI has role | CHEBI:51039 | dopamine reuptake inhibitors |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D000697 | Central Nervous System Stimulants |
MeSH PA | D015259 | Dopamine Agents |
MeSH PA | D018765 | Dopamine Uptake Inhibitors |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Narcolepsy | indication | 60380001 | DOID:8986 |
Attention deficit hyperactivity disorder | indication | 406506008 | |
Gilles de la Tourette's syndrome | contraindication | 5158005 | DOID:11119 |
Dependent drug abuse | contraindication | 6525002 | |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Feeling agitated | contraindication | 24199005 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Conduction disorder of the heart | contraindication | 44808001 | |
Chronic heart failure | contraindication | 48447003 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Anorexia nervosa | contraindication | 56882008 | DOID:8689 |
Aggressive behavior | contraindication | 61372001 | |
Substance abuse | contraindication | 66214007 | |
Psychotic disorder | contraindication | 69322001 | |
Arteriosclerotic vascular disease | contraindication | 72092001 | |
Cardiomyopathy | contraindication | 85898001 | DOID:0050700 |
Weight loss | contraindication | 89362005 | |
Structural disorder of heart | contraindication | 128599005 | |
Seizure disorder | contraindication | 128613002 | |
Motor tic disorder | contraindication | 230337001 | |
Cerebrovascular accident | contraindication | 230690007 | |
Mania | contraindication | 231494001 | |
Cardiovascular event risk | contraindication | 395112001 | |
Visual impairment | contraindication | 397540003 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Disorder of coronary artery | contraindication | 414024009 | |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Hypertensive urgency | contraindication | 443482000 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.89 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
12.5MG;12.5MG;12.5MG;12.5MG | MYDAYIS | TAKEDA PHARMS USA | N022063 | June 20, 2017 | RX | CAPSULE, EXTENDED RELEASE | ORAL | Sept. 13, 2022 | INFORMATION ADDED TO THE LABELING TO DESCRIBE A TRIAL EVALUATING A LOWER DOSE THAN THOSE APPROVED FOR PEDIATRIC PATIENTS 13 TO 17 YEARS OF AGE |
3.125MG;3.125MG;3.125MG;3.125MG | MYDAYIS | TAKEDA PHARMS USA | N022063 | June 20, 2017 | RX | CAPSULE, EXTENDED RELEASE | ORAL | Sept. 13, 2022 | INFORMATION ADDED TO THE LABELING TO DESCRIBE A TRIAL EVALUATING A LOWER DOSE THAN THOSE APPROVED FOR PEDIATRIC PATIENTS 13 TO 17 YEARS OF AGE |
6.25MG;6.25MG;6.25MG;6.25MG | MYDAYIS | TAKEDA PHARMS USA | N022063 | June 20, 2017 | RX | CAPSULE, EXTENDED RELEASE | ORAL | Sept. 13, 2022 | INFORMATION ADDED TO THE LABELING TO DESCRIBE A TRIAL EVALUATING A LOWER DOSE THAN THOSE APPROVED FOR PEDIATRIC PATIENTS 13 TO 17 YEARS OF AGE |
9.375MG;9.375MG;9.375MG;9.375MG | MYDAYIS | TAKEDA PHARMS USA | N022063 | June 20, 2017 | RX | CAPSULE, EXTENDED RELEASE | ORAL | Sept. 13, 2022 | INFORMATION ADDED TO THE LABELING TO DESCRIBE A TRIAL EVALUATING A LOWER DOSE THAN THOSE APPROVED FOR PEDIATRIC PATIENTS 13 TO 17 YEARS OF AGE |
12.5MG;12.5MG;12.5MG;12.5MG | MYDAYIS | TAKEDA PHARMS USA | N022063 | June 20, 2017 | RX | CAPSULE, EXTENDED RELEASE | ORAL | March 13, 2023 | PEDIATRIC EXCLUSIVITY |
3.125MG;3.125MG;3.125MG;3.125MG | MYDAYIS | TAKEDA PHARMS USA | N022063 | June 20, 2017 | RX | CAPSULE, EXTENDED RELEASE | ORAL | March 13, 2023 | PEDIATRIC EXCLUSIVITY |
6.25MG;6.25MG;6.25MG;6.25MG | MYDAYIS | TAKEDA PHARMS USA | N022063 | June 20, 2017 | RX | CAPSULE, EXTENDED RELEASE | ORAL | March 13, 2023 | PEDIATRIC EXCLUSIVITY |
9.375MG;9.375MG;9.375MG;9.375MG | MYDAYIS | TAKEDA PHARMS USA | N022063 | June 20, 2017 | RX | CAPSULE, EXTENDED RELEASE | ORAL | March 13, 2023 | PEDIATRIC EXCLUSIVITY |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent dopamine transporter | Transporter | RELEASING AGENT | Ki | 6.68 | WOMBAT-PK | CHEMBL | |||
Synaptic vesicular amine transporter | Transporter | INHIBITOR | CHEMBL | CHEMBL | |||||
Sodium-dependent noradrenaline transporter | Transporter | INHIBITOR | Ki | 7 | IUPHAR | CHEMBL | |||
Sodium-dependent serotonin transporter | Transporter | Ki | 5.24 | CHEMBL | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 5.18 | PDSP | |||||
Trace amine-associated receptor 1 | GPCR | EC50 | 6.87 | WOMBAT-PK | |||||
Cocaine- and amphetamine-regulated transcript protein | Transcription factor | WOMBAT-PK | |||||||
Alpha-1A adrenergic receptor | GPCR | WOMBAT-PK | |||||||
Alpha-2A adrenergic receptor | GPCR | WOMBAT-PK | |||||||
Amine oxidase [flavin-containing] A | Enzyme | Ki | 4.84 | CHEMBL | |||||
Trace amine-associated receptor 1 | GPCR | EC50 | 7.25 | CHEMBL | |||||
Trace amine-associated receptor 1 | GPCR | EC50 | 8.70 | CHEMBL | |||||
Serotonin (5-HT) receptor | GPCR | Kd | 5.35 | CHEMBL | |||||
Trace amine-associated receptor 1 | GPCR | EC50 | 6 | CHEMBL | |||||
Amine oxidase [flavin-containing] A | Enzyme | Ki | 4.91 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | IC50 | 5.31 | CHEMBL |
ID | Source |
---|---|
4019978 | VUID |
N0000148062 | NUI |
D02078 | KEGG_DRUG |
64770-52-1 | SECONDARY_CAS_RN |
4018004 | VANDF |
4018005 | VANDF |
4018835 | VANDF |
4019978 | VANDF |
C0011812 | UMLSCUI |
CHEBI:4469 | CHEBI |
1WE | PDB_CHEM_ID |
CHEMBL612 | ChEMBL_ID |
CHEMBL1200782 | ChEMBL_ID |
CHEMBL3989844 | ChEMBL_ID |
CHEMBL3544971 | ChEMBL_ID |
DB01576 | DRUGBANK_ID |
D003913 | MESH_DESCRIPTOR_UI |
5826 | PUBCHEM_CID |
2147 | IUPHAR_LIGAND_ID |
1430 | INN_ID |
TZ47U051FI | UNII |
221088 | RXNORM |
1604 | MMSL |
4563 | MMSL |
4564 | MMSL |
d00804 | MMSL |
001793 | NDDF |
001795 | NDDF |
006720 | NDDF |
387022005 | SNOMEDCT_US |
387278002 | SNOMEDCT_US |
45207006 | SNOMEDCT_US |
50868004 | SNOMEDCT_US |