dexbrompheniramine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	830	132-21-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: dexbrompheniramine d-Brompheniramine (+)-Brompheniramine dexbrompheniramine maleate	Molecular weight: 319.25 Formula: C16H19BrN2 CLOGP: 3.30 LIPINSKI: 0 HAC: 2 HDO: 0 TPSA: 16.13 ALOGS: -4.40 ROTB: 5 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dexbrompheniramine
d-Brompheniramine
(+)-Brompheniramine
dexbrompheniramine maleate

Molecular weight: 319.25
Formula: C16H19BrN2
CLOGP: 3.30
LIPINSKI: 0
HAC: 2
HDO: 0
TPSA: 16.13
ALOGS: -4.40
ROTB: 5

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
Oct. 18, 1963	FDA	SCHERING PLOUGH

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R06AB06	RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Substituted alkylamines
ATC	R06AB56	RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Substituted alkylamines
MeSH PA	D018494	Histamine Agents
MeSH PA	D006633	Histamine Antagonists
MeSH PA	D006634	Histamine H1 Antagonists
MeSH PA	D018377	Neurotransmitter Agents
CHEBI has role	CHEBI:37955	H1 receptor antagonists
CHEBI has role	CHEBI:50857	anti-allergic drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Dermatographic urticaria	indication	7632005	DOID:743
Vasomotor rhinitis	indication	8229003	DOID:4730
Allergic rhinitis	indication	61582004
Urticaria	indication	126485001
Influenza-like symptoms	indication	315642008
Seasonal allergic rhinitis	indication	367498001
Itching of skin	indication	418363000
Allergic conjunctivitis	indication	473460002	DOID:11204
Ocular hypertension	contraindication	4210003	DOID:9282
Suicidal thoughts	contraindication	6471006
Dependent drug abuse	contraindication	6525002
Alcoholism	contraindication	7200002
Alcohol withdrawal delirium	contraindication	8635005
Peptic ulcer	contraindication	13200003	DOID:750
Asthenia	contraindication	13791008
Constipation	contraindication	14760008	DOID:2089
Mood swings	contraindication	18963009
Myocardial infarction	contraindication	22298006	DOID:5844
Inflammatory bowel disease	contraindication	24526004	DOID:0050589
Ventricular tachycardia	contraindication	25569003
Alcohol intoxication	contraindication	25702006
Shock	contraindication	27942005
Hypercapnia	contraindication	29596007
Dehydration	contraindication	34095006
Hyperthyroidism	contraindication	34486009	DOID:7998
Acute hepatitis	contraindication	37871000
Hypertensive disorder	contraindication	38341003	DOID:10763
Disorder of gallbladder	contraindication	39621005	DOID:0060262
Hypothyroidism	contraindication	40930008	DOID:1459
Conduction disorder of the heart	contraindication	44808001
Low blood pressure	contraindication	45007003
Chronic heart failure	contraindication	48447003
Bradycardia	contraindication	48867003
Acidosis	contraindication	51387008
Coronary arteriosclerosis	contraindication	53741008	DOID:3393
Hepatic failure	contraindication	59927004
Ulcerative colitis	contraindication	64766004	DOID:8577
Arterial thrombosis	contraindication	65198009
Substance abuse	contraindication	66214007
Benign intracranial hypertension	contraindication	68267002	DOID:11459
Poisoning by acetaminophen	contraindication	70273001
Arteriosclerotic vascular disease	contraindication	72092001
Diabetes mellitus	contraindication	73211009	DOID:9351
Urethral stricture	contraindication	76618002
Decreased respiratory function	contraindication	80954004
Injury of head	contraindication	82271004
Chronic idiopathic constipation	contraindication	82934008
Cor pulmonale	contraindication	83291003	DOID:8515
Pulmonary emphysema	contraindication	87433001
Kidney disease	contraindication	90708001	DOID:557
Acute abdominal pain	contraindication	116290004
Neoplasm of brain	contraindication	126952004	DOID:1319
Seizure disorder	contraindication	128613002
Drug-induced psychosis	contraindication	191483003	DOID:1742
Partial atrioventricular block	contraindication	195039008
Acute pancreatitis	contraindication	197456007	DOID:2913
Disease of liver	contraindication	235856003	DOID:409
Bladder outflow obstruction	contraindication	236645006
Morbid obesity	contraindication	238136002	DOID:11981
Benign prostatic hyperplasia	contraindication	266569009
Retention of urine	contraindication	267064002
Exacerbation of asthma	contraindication	281239006
Lesion of brain	contraindication	301766008
Coma	contraindication	371632003
Primary adrenocortical insufficiency	contraindication	373662000
Operation on gastrointestinal tract	contraindication	386621005
Hypoxia	contraindication	389086002
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Disorder of coronary artery	contraindication	414024009
Central nervous system depression	contraindication	418072004
Dysfunction of sphincter of Oddi	contraindication	430887001
Hypertensive urgency	contraindication	443482000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.47	Basic
pKa2	4.14	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN	ANTAGONIST				DRUGBANK	CHEMBL

External reference:

ID	Source
4019711	VUID
N0000147803	NUI
D03704	KEGG_DRUG
2391-03-9	SECONDARY_CAS_RN
22696	RXNORM
4018841	VANDF
4019711	VANDF
C0057605	UMLSCUI
CHEBI:59269	CHEBI
CHEMBL1201287	ChEMBL_ID
DB00405	DRUGBANK_ID
CHEMBL1200638	ChEMBL_ID
C015121	MESH_SUPPLEMENTAL_RECORD_UI
16960	PUBCHEM_CID
7588	IUPHAR_LIGAND_ID
907	INN_ID
75T64B71RP	UNII
4555	MMSL
d03750	MMSL
003411	NDDF
004436	NDDF
387090008	SNOMEDCT_US
387429005	SNOMEDCT_US
75429004	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Dexbrompherniramine Maleate and Pseudoephedrine Sulfate6mg/120mg	HUMAN OTC DRUG LABEL	2	10702-005	TABLET, EXTENDED RELEASE	6 mg	ORAL	ANDA	13 sections
Chlo Tuss	HUMAN OTC DRUG LABEL	3	12830-762	LIQUID	1 mg	ORAL	OTC monograph final	16 sections
Chlo Tuss	HUMAN OTC DRUG LABEL	3	12830-762	LIQUID	1 mg	ORAL	OTC monograph final	16 sections
M-ENDDMX	HUMAN OTC DRUG LABEL	3	12830-816	LIQUID	0.67 mg	ORAL	OTC monograph final	16 sections
M-ENDDMX	HUMAN OTC DRUG LABEL	3	12830-816	LIQUID	0.67 mg	ORAL	OTC monograph final	16 sections
Chlo Hist	HUMAN OTC DRUG LABEL	2	12830-864	LIQUID	1 mg	ORAL	OTC monograph final	15 sections
Chlo Hist	HUMAN OTC DRUG LABEL	2	12830-864	LIQUID	1 mg	ORAL	OTC monograph final	15 sections
PediaVent	HUMAN OTC DRUG LABEL	1	15370-110	SYRUP	2 mg	ORAL	OTC MONOGRAPH FINAL	15 sections
PediaVent	HUMAN OTC DRUG LABEL	1	15370-112	TABLET, CHEWABLE	1 mg	ORAL	OTC MONOGRAPH FINAL	15 sections
G-Con-X	HUMAN OTC DRUG LABEL	2	43913-405	LIQUID	1 mg	ORAL	OTC MONOGRAPH FINAL	15 sections
BionatussDXP	HUMAN OTC DRUG LABEL	3	45737-210	LIQUID	2 mg	ORAL	OTC monograph final	10 sections
BIO-CNEX	HUMAN OTC DRUG LABEL	2	45737-239	LIQUID	1 mg	ORAL	OTC monograph final	9 sections
Biogesic	HUMAN OTC DRUG LABEL	2	45737-610	TABLET	1 mg	ORAL	OTC monograph not final	9 sections
Chlo Hist	HUMAN OTC DRUG LABEL	2	50090-3998	LIQUID	1 mg	ORAL	OTC monograph final	15 sections
Polytussin DM	HUMAN OTC DRUG LABEL	3	50991-121	LIQUID	2 mg	ORAL	OTC monograph final	16 sections
ALA-HIST IR	HUMAN OTC DRUG LABEL	1	50991-783	TABLET	2 mg	ORAL	OTC monograph final	13 sections
ALA-HIST IR	HUMAN OTC DRUG LABEL	1	50991-783	TABLET	2 mg	ORAL	OTC monograph final	13 sections
Alahist CF	HUMAN OTC DRUG LABEL	3	50991-784	TABLET	2 g	ORAL	OTC monograph final	10 sections
Alahist CF	HUMAN OTC DRUG LABEL	3	50991-784	TABLET	2 g	ORAL	OTC monograph final	10 sections
Alahist PE	HUMAN OTC DRUG LABEL	2	50991-788	TABLET	2 mg	ORAL	OTC monograph final	15 sections
Alahist PE	HUMAN OTC DRUG LABEL	2	50991-788	TABLET	2 mg	ORAL	OTC monograph final	15 sections
Alahist PE	HUMAN OTC DRUG LABEL	2	50991-788	TABLET	2 mg	ORAL	OTC monograph final	15 sections
ALAHISTDM	HUMAN OTC DRUG LABEL	3	50991-826	LIQUID	2 mg	ORAL	OTC monograph final	16 sections
ALAHISTDM	HUMAN OTC DRUG LABEL	3	50991-826	LIQUID	2 mg	ORAL	OTC monograph final	16 sections
SUPRESS A	HUMAN OTC DRUG LABEL	3	52083-057	SYRUP	1 mg	ORAL	OTC monograph final	12 sections
Dologen	HUMAN OTC DRUG LABEL	2	52083-481	TABLET	2 mg	ORAL	OTC monograph final	10 sections
Dologen 325	HUMAN OTC DRUG LABEL	2	52083-482	TABLET	1 mg	ORAL	OTC monograph final	10 sections
G-Dologen	HUMAN OTC DRUG LABEL	2	52083-681	TABLET	2 mg	ORAL	OTC monograph final	10 sections
DologesicNF	HUMAN OTC DRUG LABEL	2	54859-001	TABLET	1 mg	ORAL	OTC monograph not final	9 sections
DologesicDF	HUMAN OTC DRUG LABEL	2	54859-010	TABLET	1 mg	ORAL	OTC monograph not final	10 sections