Stem definition | Drug id | CAS RN |
---|---|---|
derivatives of Rauwolfia alkaloids | 810 | 131-01-1 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
April 19, 1957 | FDA |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | C02AA05 | CARDIOVASCULAR SYSTEM ANTIHYPERTENSIVES ANTIADRENERGIC AGENTS, CENTRALLY ACTING Rauwolfia alkaloids |
ATC | C02LA03 | CARDIOVASCULAR SYSTEM ANTIHYPERTENSIVES ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION Rauwolfia alkaloids and diuretics in combination |
FDA EPC | N0000175640 | Catecholamine-depleting Sympatholytic |
FDA PE | N0000175650 | Decreased Sympathetic Activity |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Fluid volume disorder | contraindication | 1860003 | |
Anuria | contraindication | 2472002 | DOID:2983 |
Hypercholesterolemia | contraindication | 13644009 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Secondary angle-closure glaucoma | contraindication | 21571006 | |
Hypovolemia | contraindication | 28560003 | |
Dehydration | contraindication | 34095006 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Hypokalemia | contraindication | 43339004 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Hypochloremic alkalosis | contraindication | 70134007 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Oliguria | contraindication | 83128009 | |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Hypomagnesemia | contraindication | 190855004 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Hypertriglyceridemia | contraindication | 302870006 | |
Azotemia | contraindication | 445009001 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.2 | acidic |
pKa2 | 6.78 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Synaptic vesicular amine transporter | Transporter | INHIBITOR | CHEMBL | CHEMBL |
ID | Source |
---|---|
4018732 | VUID |
N0000147037 | NUI |
D08194 | KEGG_DRUG |
62174 | RXNORM |
4018732 | VANDF |
C0175158 | UMLSCUI |
CHEBI:27478 | CHEBI |
CHEMBL1200515 | ChEMBL_ID |
DB01089 | DRUGBANK_ID |
C100104 | MESH_SUPPLEMENTAL_RECORD_UI |
7064 | IUPHAR_LIGAND_ID |
656 | INN_ID |
9016E3VB47 | UNII |
8550 | PUBCHEM_CID |
4544 | MMSL |
d03563 | MMSL |
000642 | NDDF |
26503009 | SNOMEDCT_US |
387144003 | SNOMEDCT_US |
None