rescinnamine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
derivatives of Rauwolfia alkaloids 2369 24815-24-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • rescinnamine
  • cinnaloid
  • methyl trimethoxycinnamoylreserpate
  • rescinnamin
  • rescisan
  • resealoid
  • reserpinine
  • scinnamina
  • moderil
  • Molecular weight: 634.73
  • Formula: C35H42N2O9
  • CLOGP: 4.12
  • LIPINSKI: 2
  • HAC: 11
  • HDO: 1
  • TPSA: 117.78
  • ALOGS: -5.26
  • ROTB: 11

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 31, 1956 FDA PFIZER

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C02AA01 CARDIOVASCULAR SYSTEM
ANTIHYPERTENSIVES
ANTIADRENERGIC AGENTS, CENTRALLY ACTING
Rauwolfia alkaloids
ATC C02LA02 CARDIOVASCULAR SYSTEM
ANTIHYPERTENSIVES
ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION
Rauwolfia alkaloids and diuretics in combination
ATC C02LA52 CARDIOVASCULAR SYSTEM
ANTIHYPERTENSIVES
ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION
Rauwolfia alkaloids and diuretics in combination
CHEBI has role CHEBI:35674 antihypertensive agent

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.2 acidic
pKa2 6.9 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Synaptic vesicular amine transporter Transporter INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4018628 VUID
N0000146941 NUI
C0035167 UMLSCUI
D00198 KEGG_DRUG
4018628 VANDF
9259 RXNORM
2927004 SNOMEDCT_US
000643 NDDF
CHEMBL1668 ChEMBL_ID
Q6W1F7DJ2D UNII
683 INN_ID
DB01180 DRUGBANK_ID
CHEBI:28572 CHEBI
5280954 PUBCHEM_CID
7098 IUPHAR_LIGAND_ID
C084826 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None