Stem definition | Drug id | CAS RN |
---|---|---|
derivatives of Rauwolfia alkaloids | 2369 | 24815-24-5 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
Oct. 31, 1956 | FDA | PFIZER |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | C02AA01 | CARDIOVASCULAR SYSTEM ANTIHYPERTENSIVES ANTIADRENERGIC AGENTS, CENTRALLY ACTING Rauwolfia alkaloids |
ATC | C02LA02 | CARDIOVASCULAR SYSTEM ANTIHYPERTENSIVES ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION Rauwolfia alkaloids and diuretics in combination |
ATC | C02LA52 | CARDIOVASCULAR SYSTEM ANTIHYPERTENSIVES ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION Rauwolfia alkaloids and diuretics in combination |
CHEBI has role | CHEBI:35674 | antihypertensive drugs |
None
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.2 | acidic |
pKa2 | 6.9 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Synaptic vesicular amine transporter | Transporter | INHIBITOR | CHEMBL | CHEMBL |
ID | Source |
---|---|
4018628 | VUID |
N0000146941 | NUI |
D00198 | KEGG_DRUG |
4018628 | VANDF |
C0035167 | UMLSCUI |
CHEBI:28572 | CHEBI |
CHEMBL1668 | ChEMBL_ID |
DB01180 | DRUGBANK_ID |
C084826 | MESH_SUPPLEMENTAL_RECORD_UI |
7098 | IUPHAR_LIGAND_ID |
683 | INN_ID |
Q6W1F7DJ2D | UNII |
5280954 | PUBCHEM_CID |
9259 | RXNORM |
000643 | NDDF |
2927004 | SNOMEDCT_US |
None