pegulicianine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
5859 2230217-17-9

Description:

MoleculeDescription

Molfile

Synonyms:

  • pegulicianine
  • pegulicianine acetate
  • lumisight
  • LUM015
Pegulicianine is a prodrug that is optically inactive when intact and produces a fluorescent signal after its peptide chain is cleaved by cathepsins and matrix metalloproteases (MMPs). The levels of these enzymes are higher in and around tumor and tumor-associated cells than normal cells.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
April 17, 2024 FDA Lumicell

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V04CX13 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Other diagnostic agents
MeSH PA D004396 Coloring Agents
MeSH PA D005456 Fluorescent Dyes
MeSH PA D007202 Indicators and Reagents
MeSH PA D049408 Luminescent Agents
CHEBI has role CHEBI:35610 antineoplastic agent

Related Drugs by ATC class:

V04CX Other diagnostic agents 9 drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Fluorescence imaging in breast cancer indication 767427005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 39MG BASE/VIAL LUMISIGHT LUMICELL N214511 April 17, 2024 RX POWDER INTRAVENOUS 9155471 Oct. 12, 2031 A METHOD COMPRISING ADMINISTERING PEGULICIANINE TO A HUMAN AND OBTAINING AN IMAGE OF A TUMOR BED AFTER TUMOR RESECTION TO DISTINGUISH IN SITU CANCER CELLS FROM HEALTHY CELLS
EQ 39MG BASE/VIAL LUMISIGHT LUMICELL N214511 April 17, 2024 RX POWDER INTRAVENOUS 10285759 Dec. 8, 2031 A METHOD COMPRISING ADMINISTERING PEGULICIANINE TO A HUMAN AND OBTAINING AN IMAGE OF A TUMOR BED AFTER TUMOR RESECTION TO DISTINGUISH IN SITU CANCER CELLS FROM HEALTHY CELLS
EQ 39MG BASE/VIAL LUMISIGHT LUMICELL N214511 April 17, 2024 RX POWDER INTRAVENOUS 9032965 Dec. 8, 2031 A METHOD COMPRISING ADMINISTERING PEGULICIANINE TO A HUMAN AND OBTAINING AN IMAGE OF A TUMOR BED AFTER TUMOR RESECTION TO DISTINGUISH IN SITU CANCER CELLS FROM HEALTHY CELLS
EQ 39MG BASE/VIAL LUMISIGHT LUMICELL N214511 April 17, 2024 RX POWDER INTRAVENOUS 9532835 Dec. 8, 2031 A METHOD COMPRISING ADMINISTERING PEGULICIANINE TO A HUMAN AND OBTAINING AN IMAGE OF A TUMOR BED AFTER TUMOR RESECTION TO DISTINGUISH IN SITU CANCER CELLS FROM HEALTHY CELLS
EQ 39MG BASE/VIAL LUMISIGHT LUMICELL N214511 April 17, 2024 RX POWDER INTRAVENOUS 9763577 Sept. 14, 2034 A METHOD COMPRISING ADMINISTERING PEGULICIANINE TO A HUMAN AND OBTAINING AN IMAGE OF A TUMOR BED AFTER TUMOR RESECTION TO DISTINGUISH IN SITU CANCER CELLS FROM HEALTHY CELLS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 39MG BASE/VIAL LUMISIGHT LUMICELL N214511 April 17, 2024 RX POWDER INTRAVENOUS April 17, 2029 NEW CHEMICAL ENTITY

Bioactivity Summary:

None

External reference:

IDSource
C000731949 MESH_SUPPLEMENTAL_RECORD_UI
4043166 VANDF
C5446783 UMLSCUI
CHEMBL4594345 ChEMBL_ID
11474 INN_ID
2230217-18-0 SECONDARY_CAS_RN
T6HE85WN0Q UNII
D12887 KEGG_DRUG
384602 MMSL
42779 MMSL
d10183 MMSL
019728 NDDF
019729 NDDF
CHEBI:757843 CHEBI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
LUMISIGHT HUMAN PRESCRIPTION DRUG LABEL 1 82292-040 Injection, powder, lyophilized, for solution 10 mg Intravenous NDA 17 sections