Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, cefalosporanic acid derivatives | 565 | 55268-75-2 |
Dose | Unit | Route |
---|---|---|
0.50 | g | O |
3 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 89 mg/mL | Bocci G, Oprea TI, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 96 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 39.35 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 32 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.15 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 2.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.10 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Oct. 19, 1983 | FDA | COVIS INJECTABLES |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Anaphylactic shock | 253.09 | 12.86 | 127 | 17971 | 23506 | 63447418 |
Anaphylactic reaction | 241.28 | 12.86 | 178 | 17920 | 65922 | 63405002 |
Macular oedema | 145.60 | 12.86 | 51 | 18047 | 3826 | 63467098 |
Retinal detachment | 141.44 | 12.86 | 56 | 18042 | 5913 | 63465011 |
Corneal oedema | 111.03 | 12.86 | 33 | 18065 | 1460 | 63469464 |
Bronchospasm | 87.57 | 12.86 | 57 | 18041 | 17223 | 63453701 |
Patent ductus arteriosus | 87.35 | 12.86 | 36 | 18062 | 4214 | 63466710 |
Type IV hypersensitivity reaction | 85.87 | 12.86 | 32 | 18066 | 2866 | 63468058 |
Foetal exposure during pregnancy | 83.99 | 12.86 | 71 | 18027 | 31891 | 63439033 |
Premature baby | 82.74 | 12.86 | 59 | 18039 | 20676 | 63450248 |
Corneal opacity | 80.38 | 12.86 | 22 | 18076 | 721 | 63470203 |
Exposure during pregnancy | 78.69 | 12.86 | 151 | 17947 | 155396 | 63315528 |
Drug reaction with eosinophilia and systemic symptoms | 74.55 | 12.86 | 68 | 18030 | 33768 | 63437156 |
Retinal oedema | 67.75 | 12.86 | 19 | 18079 | 682 | 63470242 |
Anterior chamber inflammation | 66.43 | 12.86 | 16 | 18082 | 311 | 63470613 |
Type I hypersensitivity | 64.14 | 12.86 | 26 | 18072 | 2916 | 63468008 |
Rash maculo-papular | 62.38 | 12.86 | 60 | 18038 | 31836 | 63439088 |
Endophthalmitis | 59.14 | 12.86 | 26 | 18072 | 3566 | 63467358 |
Joint swelling | 53.01 | 12.86 | 14 | 18084 | 327652 | 63143272 |
Parophthalmia | 51.45 | 12.86 | 13 | 18085 | 310 | 63470614 |
Alopecia | 49.92 | 12.86 | 17 | 18081 | 337519 | 63133405 |
Retinal toxicity | 48.74 | 12.86 | 17 | 18081 | 1258 | 63469666 |
Premature delivery | 48.28 | 12.86 | 51 | 18047 | 30230 | 63440694 |
Accidental overdose | 47.77 | 12.86 | 45 | 18053 | 23264 | 63447660 |
Dysbiosis | 46.19 | 12.86 | 15 | 18083 | 891 | 63470033 |
Cataract operation complication | 45.28 | 12.86 | 10 | 18088 | 130 | 63470794 |
Premature rupture of membranes | 45.24 | 12.86 | 24 | 18074 | 4969 | 63465955 |
Cystoid macular oedema | 45.24 | 12.86 | 17 | 18081 | 1558 | 63469366 |
Low birth weight baby | 44.89 | 12.86 | 27 | 18071 | 7102 | 63463822 |
Systemic lupus erythematosus | 44.84 | 12.86 | 4 | 18094 | 208914 | 63262010 |
Rheumatoid arthritis | 44.71 | 12.86 | 9 | 18089 | 253810 | 63217114 |
Angioedema | 43.96 | 12.86 | 61 | 18037 | 47904 | 63423020 |
Cross sensitivity reaction | 43.36 | 12.86 | 18 | 18080 | 2144 | 63468780 |
Retinopathy | 43.17 | 12.86 | 20 | 18078 | 3099 | 63467825 |
Corneal deposits | 42.59 | 12.86 | 11 | 18087 | 287 | 63470637 |
Arthropathy | 42.03 | 12.86 | 8 | 18090 | 234784 | 63236140 |
Clostridium difficile infection | 41.78 | 12.86 | 47 | 18051 | 29875 | 63441049 |
Drug interaction | 41.07 | 12.86 | 151 | 17947 | 228980 | 63241944 |
Resuscitation | 38.97 | 12.86 | 14 | 18084 | 1130 | 63469794 |
Swelling | 38.79 | 12.86 | 15 | 18083 | 275363 | 63195561 |
Infusion related reaction | 38.73 | 12.86 | 11 | 18087 | 245510 | 63225414 |
Visual acuity reduced | 37.01 | 12.86 | 38 | 18060 | 21788 | 63449136 |
Congenital tricuspid valve incompetence | 36.97 | 12.86 | 8 | 18090 | 94 | 63470830 |
Circulatory collapse | 36.85 | 12.86 | 38 | 18060 | 21900 | 63449024 |
Kounis syndrome | 36.72 | 12.86 | 15 | 18083 | 1715 | 63469209 |
Multiple organ dysfunction syndrome | 36.20 | 12.86 | 61 | 18037 | 56691 | 63414233 |
Toxic epidermal necrolysis | 35.72 | 12.86 | 40 | 18058 | 25294 | 63445630 |
Hypotension | 35.66 | 12.86 | 163 | 17935 | 272441 | 63198483 |
Meningitis candida | 35.24 | 12.86 | 7 | 18091 | 52 | 63470872 |
Treatment failure | 35.16 | 12.86 | 7 | 18091 | 199036 | 63271888 |
Congenital pulmonary hypertension | 34.67 | 12.86 | 7 | 18091 | 57 | 63470867 |
Pneumonia mycoplasmal | 34.08 | 12.86 | 12 | 18086 | 913 | 63470011 |
Therapeutic product effect decreased | 33.70 | 12.86 | 7 | 18091 | 193180 | 63277744 |
Conjunctival oedema | 33.28 | 12.86 | 11 | 18087 | 691 | 63470233 |
Airway peak pressure increased | 33.14 | 12.86 | 9 | 18089 | 286 | 63470638 |
Toxic anterior segment syndrome | 33.03 | 12.86 | 14 | 18084 | 1757 | 63469167 |
Trimethylaminuria | 32.76 | 12.86 | 8 | 18090 | 165 | 63470759 |
Lip swelling | 32.27 | 12.86 | 42 | 18056 | 31021 | 63439903 |
Contraindicated product administered | 32.09 | 12.86 | 11 | 18087 | 217637 | 63253287 |
Fatigue | 31.79 | 12.86 | 138 | 17960 | 887890 | 62583034 |
Drug intolerance | 31.64 | 12.86 | 25 | 18073 | 308636 | 63162288 |
Toxoplasmosis | 31.63 | 12.86 | 13 | 18085 | 1510 | 63469414 |
Foetal non-stress test abnormal | 31.61 | 12.86 | 6 | 18092 | 34 | 63470890 |
Musculoskeletal stiffness | 31.56 | 12.86 | 7 | 18091 | 184611 | 63286313 |
Face oedema | 30.38 | 12.86 | 33 | 18065 | 20179 | 63450745 |
Cardiac massage | 29.70 | 12.86 | 5 | 18093 | 12 | 63470912 |
Stevens-Johnson syndrome | 29.52 | 12.86 | 36 | 18062 | 24914 | 63446010 |
Anterior chamber fibrin | 29.38 | 12.86 | 6 | 18092 | 52 | 63470872 |
Cardiovascular insufficiency | 28.91 | 12.86 | 12 | 18086 | 1429 | 63469495 |
Urticaria | 28.62 | 12.86 | 108 | 17990 | 165694 | 63305230 |
Pseudomembranous colitis | 28.31 | 12.86 | 15 | 18083 | 3097 | 63467827 |
Product monitoring error | 28.17 | 12.86 | 17 | 18081 | 4499 | 63466425 |
Tachypnoea | 27.32 | 12.86 | 29 | 18069 | 17273 | 63453651 |
Pain | 27.13 | 12.86 | 114 | 17984 | 740514 | 62730410 |
Pericarditis | 26.96 | 12.86 | 3 | 18095 | 131576 | 63339348 |
Joint hyperextension | 26.80 | 12.86 | 8 | 18090 | 359 | 63470565 |
Blood pressure decreased | 26.74 | 12.86 | 58 | 18040 | 64964 | 63405960 |
Antidiuretic hormone abnormality | 26.70 | 12.86 | 5 | 18093 | 26 | 63470898 |
Sepsis syndrome | 26.45 | 12.86 | 10 | 18088 | 932 | 63469992 |
Drug hypersensitivity | 26.39 | 12.86 | 165 | 17933 | 310522 | 63160402 |
Nephritis allergic | 25.98 | 12.86 | 7 | 18091 | 216 | 63470708 |
Boutonneuse fever | 25.88 | 12.86 | 4 | 18094 | 4 | 63470920 |
Vulval cancer metastatic | 25.88 | 12.86 | 4 | 18094 | 4 | 63470920 |
Macular ischaemia | 25.56 | 12.86 | 5 | 18093 | 34 | 63470890 |
Linear IgA disease | 25.51 | 12.86 | 11 | 18087 | 1440 | 63469484 |
Oesophageal spasm | 25.47 | 12.86 | 14 | 18084 | 3109 | 63467815 |
Discomfort | 25.47 | 12.86 | 8 | 18090 | 167366 | 63303558 |
Staphylococcal sepsis | 25.44 | 12.86 | 20 | 18078 | 8108 | 63462816 |
Ocular toxicity | 25.36 | 12.86 | 9 | 18089 | 701 | 63470223 |
Hypopyon | 25.09 | 12.86 | 9 | 18089 | 723 | 63470201 |
Clostridium difficile colitis | 24.85 | 12.86 | 30 | 18068 | 20539 | 63450385 |
Arthralgia | 23.86 | 12.86 | 83 | 18015 | 569627 | 62901297 |
Oliguria | 23.45 | 12.86 | 20 | 18078 | 9081 | 63461843 |
Oesophageal pain | 23.26 | 12.86 | 14 | 18084 | 3687 | 63467237 |
Renal failure | 23.15 | 12.86 | 80 | 18018 | 117572 | 63353352 |
Toxic skin eruption | 22.88 | 12.86 | 23 | 18075 | 12862 | 63458062 |
Weight increased | 22.16 | 12.86 | 25 | 18073 | 260767 | 63210157 |
Jaundice | 22.14 | 12.86 | 34 | 18064 | 29217 | 63441707 |
Tachycardia | 22.09 | 12.86 | 79 | 18019 | 118077 | 63352847 |
Restlessness | 21.97 | 12.86 | 34 | 18064 | 29419 | 63441505 |
Hyperleukocytosis | 21.89 | 12.86 | 8 | 18090 | 678 | 63470246 |
Erythema | 21.41 | 12.86 | 103 | 17995 | 175648 | 63295276 |
Pyroglutamate increased | 21.27 | 12.86 | 7 | 18091 | 434 | 63470490 |
Wound | 21.20 | 12.86 | 10 | 18088 | 163253 | 63307671 |
Abdominal discomfort | 21.06 | 12.86 | 37 | 18061 | 320848 | 63150076 |
Bulimia nervosa | 20.77 | 12.86 | 7 | 18091 | 467 | 63470457 |
Foetal anaemia | 20.77 | 12.86 | 5 | 18093 | 97 | 63470827 |
Nosocomial infection | 20.64 | 12.86 | 10 | 18088 | 1711 | 63469213 |
Merycism | 19.98 | 12.86 | 6 | 18092 | 275 | 63470649 |
Product preparation issue | 19.87 | 12.86 | 9 | 18089 | 1323 | 63469601 |
Vanishing twin syndrome | 19.80 | 12.86 | 5 | 18093 | 119 | 63470805 |
Sepsis | 19.57 | 12.86 | 91 | 18007 | 153032 | 63317892 |
Delayed delivery | 19.35 | 12.86 | 4 | 18094 | 37 | 63470887 |
Idiopathic angioedema | 19.26 | 12.86 | 4 | 18094 | 38 | 63470886 |
Natural killer cell count decreased | 19.07 | 12.86 | 4 | 18094 | 40 | 63470884 |
Hydronephrosis | 18.87 | 12.86 | 19 | 18079 | 10643 | 63460281 |
Colitis ischaemic | 18.80 | 12.86 | 19 | 18079 | 10689 | 63460235 |
Acute kidney injury | 18.79 | 12.86 | 134 | 17964 | 263281 | 63207643 |
Exophthalmos | 18.76 | 12.86 | 9 | 18089 | 1507 | 63469417 |
Cutaneous vasculitis | 18.76 | 12.86 | 14 | 18084 | 5255 | 63465669 |
Hepatic enzyme increased | 18.76 | 12.86 | 18 | 18080 | 202310 | 63268614 |
Coma blister | 18.53 | 12.86 | 5 | 18093 | 155 | 63470769 |
Tinnitus | 18.48 | 12.86 | 35 | 18063 | 35593 | 63435331 |
Retroplacental haematoma | 18.41 | 12.86 | 5 | 18093 | 159 | 63470765 |
Pyelonephritis | 18.40 | 12.86 | 24 | 18074 | 17754 | 63453170 |
Serous retinal detachment | 18.40 | 12.86 | 6 | 18092 | 361 | 63470563 |
Anaphylactoid reaction | 18.17 | 12.86 | 12 | 18086 | 3711 | 63467213 |
Maculopathy | 18.06 | 12.86 | 10 | 18088 | 2252 | 63468672 |
Eye inflammation | 18.00 | 12.86 | 14 | 18084 | 5585 | 63465339 |
Intentional product use issue | 17.93 | 12.86 | 7 | 18091 | 127885 | 63343039 |
Mediastinal effusion | 17.71 | 12.86 | 4 | 18094 | 58 | 63470866 |
Moraxella infection | 17.24 | 12.86 | 6 | 18092 | 441 | 63470483 |
Retinal infarction | 17.22 | 12.86 | 4 | 18094 | 66 | 63470858 |
Hepatitis toxic | 17.14 | 12.86 | 11 | 18087 | 3242 | 63467682 |
Pneumonia | 17.06 | 12.86 | 202 | 17896 | 456565 | 63014359 |
Pupillary block | 16.67 | 12.86 | 3 | 18095 | 12 | 63470912 |
Congenital lymphoedema | 16.67 | 12.86 | 3 | 18095 | 12 | 63470912 |
Dermatitis allergic | 16.54 | 12.86 | 21 | 18077 | 15127 | 63455797 |
Delivery | 16.37 | 12.86 | 8 | 18090 | 1395 | 63469529 |
Bradycardia | 16.36 | 12.86 | 52 | 18046 | 73175 | 63397749 |
Cerebral mass effect | 16.31 | 12.86 | 7 | 18091 | 906 | 63470018 |
Anaemia of malignant disease | 16.19 | 12.86 | 6 | 18092 | 529 | 63470395 |
Deafness bilateral | 16.16 | 12.86 | 8 | 18090 | 1434 | 63469490 |
Coagulation time prolonged | 16.13 | 12.86 | 8 | 18090 | 1440 | 63469484 |
Stenosis | 16.10 | 12.86 | 8 | 18090 | 1446 | 63469478 |
Neonatal respiratory distress syndrome | 16.02 | 12.86 | 10 | 18088 | 2808 | 63468116 |
Lower respiratory tract infection | 15.84 | 12.86 | 9 | 18089 | 132298 | 63338626 |
Toxicity to various agents | 15.78 | 12.86 | 29 | 18069 | 247221 | 63223703 |
Vitreous disorder | 15.69 | 12.86 | 4 | 18094 | 99 | 63470825 |
Live birth | 15.61 | 12.86 | 27 | 18071 | 25603 | 63445321 |
Acinetobacter infection | 15.45 | 12.86 | 8 | 18090 | 1575 | 63469349 |
Lip oedema | 15.27 | 12.86 | 11 | 18087 | 3913 | 63467011 |
B-lymphocyte count increased | 15.02 | 12.86 | 4 | 18094 | 118 | 63470806 |
Retinal disorder | 14.96 | 12.86 | 8 | 18090 | 1682 | 63469242 |
Blood creatinine increased | 14.95 | 12.86 | 57 | 18041 | 87787 | 63383137 |
Gestational diabetes | 14.93 | 12.86 | 15 | 18083 | 8381 | 63462543 |
Intermittent positive pressure breathing | 14.91 | 12.86 | 3 | 18095 | 24 | 63470900 |
Cardiac arrest | 14.90 | 12.86 | 59 | 18039 | 92486 | 63378438 |
Tubulointerstitial nephritis | 14.88 | 12.86 | 23 | 18075 | 19880 | 63451044 |
Hypersensitivity vasculitis | 14.80 | 12.86 | 11 | 18087 | 4101 | 63466823 |
Urticaria contact | 14.80 | 12.86 | 3 | 18095 | 25 | 63470899 |
Cyanosis | 14.71 | 12.86 | 21 | 18077 | 16914 | 63454010 |
Shock | 14.66 | 12.86 | 25 | 18073 | 23438 | 63447486 |
Spinal muscular atrophy | 14.59 | 12.86 | 3 | 18095 | 27 | 63470897 |
Abortion late | 14.50 | 12.86 | 4 | 18094 | 135 | 63470789 |
Nasopharyngitis | 14.36 | 12.86 | 32 | 18066 | 254225 | 63216699 |
HER2 positive breast cancer | 14.32 | 12.86 | 5 | 18093 | 371 | 63470553 |
Cholestatic liver injury | 14.18 | 12.86 | 9 | 18089 | 2601 | 63468323 |
Hepatosplenomegaly | 14.17 | 12.86 | 9 | 18089 | 2605 | 63468319 |
Gait disturbance | 14.04 | 12.86 | 19 | 18079 | 183159 | 63287765 |
Lymphoedema | 14.04 | 12.86 | 17 | 18081 | 11675 | 63459249 |
Brain compression | 13.90 | 12.86 | 5 | 18093 | 405 | 63470519 |
Product prescribing error | 13.85 | 12.86 | 26 | 18072 | 26263 | 63444661 |
Cogwheel rigidity | 13.82 | 12.86 | 8 | 18090 | 1962 | 63468962 |
Enanthema | 13.71 | 12.86 | 5 | 18093 | 421 | 63470503 |
Sinobronchitis | 13.68 | 12.86 | 4 | 18094 | 167 | 63470757 |
Hypotonia | 13.67 | 12.86 | 15 | 18083 | 9270 | 63461654 |
Disturbance in attention | 13.40 | 12.86 | 32 | 18066 | 38157 | 63432767 |
Fall | 13.33 | 12.86 | 62 | 18036 | 392272 | 63078652 |
Pelvic fluid collection | 13.33 | 12.86 | 6 | 18092 | 870 | 63470054 |
Hallucination | 13.24 | 12.86 | 40 | 18058 | 54777 | 63416147 |
Normal newborn | 13.20 | 12.86 | 14 | 18084 | 8327 | 63462597 |
Nail avulsion | 13.12 | 12.86 | 4 | 18094 | 193 | 63470731 |
Paranasal sinus inflammation | 12.98 | 12.86 | 5 | 18093 | 490 | 63470434 |
Intraocular pressure increased | 12.96 | 12.86 | 12 | 18086 | 6066 | 63464858 |
Metabolic acidosis | 12.94 | 12.86 | 35 | 18063 | 45034 | 63425890 |
Arteriospasm coronary | 12.93 | 12.86 | 10 | 18088 | 3958 | 63466966 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Type IV hypersensitivity reaction | 162.34 | 14.92 | 48 | 14788 | 1386 | 34940709 |
Anaphylactic reaction | 139.40 | 14.92 | 113 | 14723 | 32188 | 34909907 |
Anaphylactic shock | 129.54 | 14.92 | 82 | 14754 | 15859 | 34926236 |
Lung consolidation | 120.29 | 14.92 | 56 | 14780 | 5880 | 34936215 |
Soft tissue mass | 89.23 | 14.92 | 28 | 14808 | 991 | 34941104 |
Multimorbidity | 87.17 | 14.92 | 27 | 14809 | 915 | 34941180 |
Rash maculo-papular | 83.50 | 14.92 | 80 | 14756 | 28371 | 34913724 |
Oesophageal perforation | 80.76 | 14.92 | 27 | 14809 | 1172 | 34940923 |
Retinal infarction | 79.84 | 14.92 | 17 | 14819 | 118 | 34941977 |
Retinal toxicity | 78.38 | 14.92 | 21 | 14815 | 419 | 34941676 |
Macular oedema | 76.64 | 14.92 | 33 | 14803 | 2881 | 34939214 |
Spinal muscular atrophy | 71.01 | 14.92 | 19 | 14817 | 377 | 34941718 |
Pyrexia | 70.30 | 14.92 | 303 | 14533 | 332710 | 34609385 |
Superinfection | 67.81 | 14.92 | 29 | 14807 | 2490 | 34939605 |
Drug reaction with eosinophilia and systemic symptoms | 66.65 | 14.92 | 76 | 14760 | 32936 | 34909159 |
Inflammatory marker increased | 65.08 | 14.92 | 35 | 14801 | 4993 | 34937102 |
Resuscitation | 64.51 | 14.92 | 24 | 14812 | 1429 | 34940666 |
Pneumococcal sepsis | 62.53 | 14.92 | 22 | 14814 | 1115 | 34940980 |
Macular detachment | 60.12 | 14.92 | 13 | 14823 | 98 | 34941997 |
Endophthalmitis | 58.62 | 14.92 | 29 | 14807 | 3479 | 34938616 |
Transplant failure | 58.27 | 14.92 | 29 | 14807 | 3524 | 34938571 |
Stoma closure | 57.75 | 14.92 | 15 | 14821 | 264 | 34941831 |
Retinal detachment | 57.39 | 14.92 | 33 | 14803 | 5358 | 34936737 |
Ocular toxicity | 55.15 | 14.92 | 14 | 14822 | 224 | 34941871 |
Toxic epidermal necrolysis | 54.49 | 14.92 | 56 | 14780 | 21590 | 34920505 |
Corneal oedema | 51.63 | 14.92 | 20 | 14816 | 1331 | 34940764 |
Motor neurone disease | 48.60 | 14.92 | 15 | 14821 | 502 | 34941593 |
Lymphadenectomy | 48.41 | 14.92 | 14 | 14822 | 373 | 34941722 |
Rales | 47.79 | 14.92 | 37 | 14799 | 9846 | 34932249 |
Ischaemic cerebral infarction | 46.02 | 14.92 | 18 | 14818 | 1229 | 34940866 |
Retinal oedema | 45.27 | 14.92 | 15 | 14821 | 633 | 34941462 |
Increased bronchial secretion | 45.23 | 14.92 | 20 | 14816 | 1861 | 34940234 |
Bronchial disorder | 43.96 | 14.92 | 18 | 14818 | 1385 | 34940710 |
Sputum increased | 43.83 | 14.92 | 21 | 14815 | 2349 | 34939746 |
Anticoagulation drug level above therapeutic | 42.98 | 14.92 | 20 | 14816 | 2096 | 34939999 |
Clostridium difficile colitis | 41.96 | 14.92 | 42 | 14794 | 15688 | 34926407 |
Immunosuppressant drug level increased | 41.47 | 14.92 | 28 | 14808 | 6027 | 34936068 |
Lower respiratory tract infection bacterial | 40.69 | 14.92 | 13 | 14823 | 488 | 34941607 |
Injury | 40.68 | 14.92 | 47 | 14789 | 20640 | 34921455 |
Respiratory tract infection bacterial | 39.82 | 14.92 | 18 | 14818 | 1764 | 34940331 |
Metabolic disorder | 39.77 | 14.92 | 24 | 14812 | 4259 | 34937836 |
Bronchospasm | 38.93 | 14.92 | 34 | 14802 | 10697 | 34931398 |
Oesophageal carcinoma | 38.93 | 14.92 | 32 | 14804 | 9272 | 34932823 |
Lack of spontaneous speech | 38.72 | 14.92 | 8 | 14828 | 47 | 34942048 |
Disease complication | 38.10 | 14.92 | 20 | 14816 | 2716 | 34939379 |
Chest X-ray abnormal | 36.64 | 14.92 | 23 | 14813 | 4375 | 34937720 |
Tachypnoea | 36.60 | 14.92 | 42 | 14794 | 18310 | 34923785 |
Pathogen resistance | 36.34 | 14.92 | 31 | 14805 | 9451 | 34932644 |
Death | 35.00 | 14.92 | 73 | 14763 | 397976 | 34544119 |
Foetal exposure during pregnancy | 34.91 | 14.92 | 60 | 14776 | 38041 | 34904054 |
Pulmonary vasculitis | 34.51 | 14.92 | 12 | 14824 | 587 | 34941508 |
Intestinal intraepithelial lymphocytes increased | 34.51 | 14.92 | 9 | 14827 | 161 | 34941934 |
Clostridium difficile infection | 33.95 | 14.92 | 41 | 14795 | 18857 | 34923238 |
Kounis syndrome | 33.91 | 14.92 | 18 | 14818 | 2500 | 34939595 |
Small for dates baby | 33.89 | 14.92 | 21 | 14815 | 3906 | 34938189 |
Congenital pneumonia | 33.80 | 14.92 | 8 | 14828 | 94 | 34942001 |
Intestinal ischaemia | 33.01 | 14.92 | 27 | 14809 | 7767 | 34934328 |
Renal injury | 31.92 | 14.92 | 31 | 14805 | 11164 | 34930931 |
Escherichia infection | 31.69 | 14.92 | 27 | 14809 | 8218 | 34933877 |
Cryptitis | 31.59 | 14.92 | 9 | 14827 | 227 | 34941868 |
Nervous system neoplasm | 30.32 | 14.92 | 8 | 14828 | 150 | 34941945 |
Myocardial ischaemia | 30.03 | 14.92 | 37 | 14799 | 17371 | 34924724 |
Neuritis | 29.32 | 14.92 | 12 | 14824 | 922 | 34941173 |
Motor dysfunction | 29.21 | 14.92 | 24 | 14812 | 6950 | 34935145 |
Inflammation | 29.18 | 14.92 | 47 | 14789 | 28248 | 34913847 |
Biopsy | 29.08 | 14.92 | 9 | 14827 | 304 | 34941791 |
Microvillous inclusion disease | 28.46 | 14.92 | 8 | 14828 | 192 | 34941903 |
Haemoptysis | 28.05 | 14.92 | 52 | 14784 | 34954 | 34907141 |
Brain injury | 27.54 | 14.92 | 22 | 14814 | 6120 | 34935975 |
Pneumonia | 27.00 | 14.92 | 253 | 14583 | 362374 | 34579721 |
Apoptosis | 26.67 | 14.92 | 9 | 14827 | 402 | 34941693 |
Drug abuse | 26.46 | 14.92 | 5 | 14831 | 99091 | 34843004 |
Probiotic therapy | 26.45 | 14.92 | 7 | 14829 | 133 | 34941962 |
Fear | 26.17 | 14.92 | 27 | 14809 | 10449 | 34931646 |
Maculopathy | 25.82 | 14.92 | 11 | 14825 | 935 | 34941160 |
Renal graft infection | 25.49 | 14.92 | 8 | 14828 | 283 | 34941812 |
Cardiomegaly | 25.33 | 14.92 | 32 | 14804 | 15406 | 34926689 |
Atelectasis | 24.83 | 14.92 | 34 | 14802 | 17693 | 34924402 |
Scoliosis | 24.26 | 14.92 | 15 | 14821 | 2778 | 34939317 |
Visual acuity reduced | 24.19 | 14.92 | 32 | 14804 | 16117 | 34925978 |
Dysphagia | 23.63 | 14.92 | 69 | 14767 | 62312 | 34879783 |
Rotavirus infection | 22.90 | 14.92 | 8 | 14828 | 397 | 34941698 |
Acute hepatic failure | 22.81 | 14.92 | 29 | 14807 | 14045 | 34928050 |
Fluid intake reduced | 22.71 | 14.92 | 16 | 14820 | 3685 | 34938410 |
Demyelination | 22.31 | 14.92 | 15 | 14821 | 3206 | 34938889 |
Acute pulmonary oedema | 22.19 | 14.92 | 21 | 14815 | 7322 | 34934773 |
Ascites | 22.13 | 14.92 | 56 | 14780 | 46515 | 34895580 |
Acute generalised exanthematous pustulosis | 21.67 | 14.92 | 20 | 14816 | 6756 | 34935339 |
Platelet count decreased | 21.54 | 14.92 | 12 | 14824 | 119705 | 34822390 |
Product dose omission issue | 21.54 | 14.92 | 12 | 14824 | 119699 | 34822396 |
Fibrinolysis increased | 21.28 | 14.92 | 4 | 14832 | 13 | 34942082 |
Cerebral ischaemia | 20.88 | 14.92 | 19 | 14817 | 6303 | 34935792 |
Atheroembolism | 20.52 | 14.92 | 7 | 14829 | 323 | 34941772 |
Nosocomial infection | 20.36 | 14.92 | 10 | 14826 | 1181 | 34940914 |
Labelled drug-drug interaction medication error | 19.94 | 14.92 | 28 | 14808 | 14911 | 34927184 |
Systemic infection | 19.89 | 14.92 | 17 | 14819 | 5195 | 34936900 |
Productive cough | 19.59 | 14.92 | 47 | 14789 | 37766 | 34904329 |
Shock | 19.47 | 14.92 | 36 | 14800 | 24143 | 34917952 |
Respiratory symptom | 19.12 | 14.92 | 11 | 14825 | 1786 | 34940309 |
Circulatory collapse | 19.09 | 14.92 | 33 | 14803 | 21005 | 34921090 |
Fatigue | 18.95 | 14.92 | 87 | 14749 | 370566 | 34571529 |
Weight increased | 18.75 | 14.92 | 8 | 14828 | 93025 | 34849070 |
Erythema | 18.74 | 14.92 | 81 | 14755 | 88699 | 34853396 |
Escherichia urinary tract infection | 18.73 | 14.92 | 14 | 14822 | 3532 | 34938563 |
Genitourinary tract infection | 18.42 | 14.92 | 5 | 14831 | 105 | 34941990 |
Mechanical ventilation | 18.19 | 14.92 | 11 | 14825 | 1959 | 34940136 |
Urticaria | 18.14 | 14.92 | 63 | 14773 | 62314 | 34879781 |
Pneumococcal infection | 18.05 | 14.92 | 7 | 14829 | 467 | 34941628 |
Mastocytosis | 17.97 | 14.92 | 4 | 14832 | 35 | 34942060 |
Lip ulceration | 17.92 | 14.92 | 8 | 14828 | 761 | 34941334 |
Retinopathy | 17.71 | 14.92 | 11 | 14825 | 2053 | 34940042 |
Blood pressure decreased | 17.64 | 14.92 | 55 | 14781 | 51460 | 34890635 |
Dyspnoea | 17.58 | 14.92 | 240 | 14596 | 376542 | 34565553 |
Bronchopneumopathy | 17.53 | 14.92 | 7 | 14829 | 505 | 34941590 |
Patent ductus arteriosus | 17.18 | 14.92 | 13 | 14823 | 3341 | 34938754 |
Malignant neoplasm progression | 17.07 | 14.92 | 8 | 14828 | 88038 | 34854057 |
Pseudomembranous colitis | 16.98 | 14.92 | 12 | 14824 | 2779 | 34939316 |
Venous thrombosis | 16.91 | 14.92 | 13 | 14823 | 3422 | 34938673 |
Foetal growth restriction | 16.89 | 14.92 | 14 | 14822 | 4103 | 34937992 |
Lymphangitis | 16.86 | 14.92 | 7 | 14829 | 558 | 34941537 |
Serratia infection | 16.79 | 14.92 | 8 | 14828 | 884 | 34941211 |
Optic atrophy | 16.60 | 14.92 | 8 | 14828 | 906 | 34941189 |
Insomnia | 16.52 | 14.92 | 12 | 14824 | 103895 | 34838200 |
Normochromic normocytic anaemia | 16.39 | 14.92 | 14 | 14822 | 4273 | 34937822 |
Multiple organ dysfunction syndrome | 16.26 | 14.92 | 70 | 14766 | 76496 | 34865599 |
Retinal haemorrhage | 16.24 | 14.92 | 15 | 14821 | 5074 | 34937021 |
Cross sensitivity reaction | 16.08 | 14.92 | 9 | 14827 | 1388 | 34940707 |
Endotracheal intubation | 15.97 | 14.92 | 12 | 14824 | 3053 | 34939042 |
Arthralgia | 15.89 | 14.92 | 30 | 14806 | 170011 | 34772084 |
Acquired haemophilia | 15.84 | 14.92 | 8 | 14828 | 1002 | 34941093 |
Pneumonectomy | 15.70 | 14.92 | 4 | 14832 | 65 | 34942030 |
Vesicoureteric reflux | 15.57 | 14.92 | 5 | 14831 | 191 | 34941904 |
Rhinalgia | 15.53 | 14.92 | 8 | 14828 | 1045 | 34941050 |
Haemorrhoids thrombosed | 15.32 | 14.92 | 5 | 14831 | 201 | 34941894 |
Product preparation issue | 15.31 | 14.92 | 6 | 14830 | 412 | 34941683 |
Feeling abnormal | 15.24 | 14.92 | 4 | 14832 | 63231 | 34878864 |
Cerebellar stroke | 14.95 | 14.92 | 5 | 14831 | 217 | 34941878 |
Blepharospasm | 14.94 | 14.92 | 8 | 14828 | 1130 | 34940965 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Anaphylactic reaction | 361.90 | 12.31 | 276 | 28954 | 83467 | 79631691 |
Anaphylactic shock | 335.86 | 12.31 | 192 | 29038 | 35804 | 79679354 |
Type IV hypersensitivity reaction | 243.94 | 12.31 | 81 | 29149 | 4000 | 79711158 |
Macular oedema | 231.81 | 12.31 | 84 | 29146 | 5390 | 79709768 |
Retinal detachment | 195.60 | 12.31 | 86 | 29144 | 9161 | 79705997 |
Corneal oedema | 156.57 | 12.31 | 52 | 29178 | 2568 | 79712590 |
Rash maculo-papular | 139.87 | 12.31 | 135 | 29095 | 55943 | 79659215 |
Drug reaction with eosinophilia and systemic symptoms | 136.93 | 12.31 | 142 | 29088 | 64102 | 79651056 |
Retinal toxicity | 130.14 | 12.31 | 39 | 29191 | 1372 | 79713786 |
Bronchospasm | 118.52 | 12.31 | 87 | 29143 | 24772 | 79690386 |
Retinal oedema | 117.05 | 12.31 | 33 | 29197 | 932 | 79714226 |
Retinal infarction | 108.62 | 12.31 | 23 | 29207 | 183 | 79714975 |
Endophthalmitis | 108.21 | 12.31 | 51 | 29179 | 6377 | 79708781 |
Lung consolidation | 106.24 | 12.31 | 56 | 29174 | 8891 | 79706267 |
Resuscitation | 98.46 | 12.31 | 36 | 29194 | 2368 | 79712790 |
Anterior chamber inflammation | 89.90 | 12.31 | 24 | 29206 | 550 | 79714608 |
Clostridium difficile infection | 86.73 | 12.31 | 92 | 29138 | 42593 | 79672565 |
Corneal opacity | 84.68 | 12.31 | 26 | 29204 | 994 | 79714164 |
Soft tissue mass | 82.74 | 12.31 | 27 | 29203 | 1261 | 79713897 |
Visual acuity reduced | 77.35 | 12.31 | 73 | 29157 | 29396 | 79685762 |
Multimorbidity | 75.88 | 12.31 | 26 | 29204 | 1413 | 79713745 |
Ocular toxicity | 75.45 | 12.31 | 23 | 29207 | 858 | 79714300 |
Oesophageal perforation | 73.65 | 12.31 | 26 | 29204 | 1545 | 79713613 |
Kounis syndrome | 69.10 | 12.31 | 33 | 29197 | 4249 | 79710909 |
Spinal muscular atrophy | 68.60 | 12.31 | 18 | 29212 | 385 | 79714773 |
Type I hypersensitivity | 68.26 | 12.31 | 33 | 29197 | 4365 | 79710793 |
Macular detachment | 68.23 | 12.31 | 16 | 29214 | 211 | 79714947 |
Clostridium difficile colitis | 66.32 | 12.31 | 70 | 29160 | 32213 | 79682945 |
Exposure during pregnancy | 61.72 | 12.31 | 123 | 29107 | 101009 | 79614149 |
Toxic epidermal necrolysis | 60.32 | 12.31 | 78 | 29152 | 44503 | 79670655 |
Joint swelling | 59.72 | 12.31 | 16 | 29214 | 288630 | 79426528 |
Tachypnoea | 59.69 | 12.31 | 66 | 29164 | 31997 | 79683161 |
Stoma closure | 58.41 | 12.31 | 15 | 29215 | 294 | 79714864 |
Cross sensitivity reaction | 58.05 | 12.31 | 28 | 29202 | 3684 | 79711474 |
Accidental overdose | 57.91 | 12.31 | 72 | 29158 | 39509 | 79675649 |
Pneumococcal sepsis | 57.52 | 12.31 | 22 | 29208 | 1640 | 79713518 |
Corneal deposits | 55.76 | 12.31 | 16 | 29214 | 482 | 79714676 |
Pyrexia | 53.55 | 12.31 | 428 | 28802 | 678281 | 79036877 |
Circulatory collapse | 52.68 | 12.31 | 67 | 29163 | 37601 | 79677557 |
Transplant failure | 52.14 | 12.31 | 28 | 29202 | 4613 | 79710545 |
Superinfection | 50.70 | 12.31 | 28 | 29202 | 4874 | 79710284 |
Infusion related reaction | 49.08 | 12.31 | 12 | 29218 | 230225 | 79484933 |
Pathogen resistance | 48.49 | 12.31 | 41 | 29189 | 14301 | 79700857 |
Multiple organ dysfunction syndrome | 48.45 | 12.31 | 124 | 29106 | 120122 | 79595036 |
Motor neurone disease | 48.37 | 12.31 | 15 | 29215 | 593 | 79714565 |
Arthropathy | 47.16 | 12.31 | 5 | 29225 | 177106 | 79538052 |
Cystoid macular oedema | 47.06 | 12.31 | 20 | 29210 | 1960 | 79713198 |
Fatigue | 46.34 | 12.31 | 180 | 29050 | 929547 | 78785611 |
Rheumatoid arthritis | 46.15 | 12.31 | 10 | 29220 | 208460 | 79506698 |
Weight increased | 46.11 | 12.31 | 22 | 29208 | 277364 | 79437794 |
Rales | 45.84 | 12.31 | 46 | 29184 | 19955 | 79695203 |
Pseudomembranous colitis | 45.66 | 12.31 | 27 | 29203 | 5347 | 79709811 |
Inflammatory marker increased | 43.26 | 12.31 | 34 | 29196 | 10706 | 79704452 |
Maculopathy | 43.25 | 12.31 | 21 | 29209 | 2804 | 79712354 |
Urticaria | 42.66 | 12.31 | 157 | 29073 | 185044 | 79530114 |
Renal injury | 42.65 | 12.31 | 41 | 29189 | 16886 | 79698272 |
Alopecia | 42.20 | 12.31 | 16 | 29214 | 231339 | 79483819 |
Dysbiosis | 41.70 | 12.31 | 16 | 29214 | 1203 | 79713955 |
Anticoagulation drug level above therapeutic | 41.12 | 12.31 | 22 | 29208 | 3598 | 79711560 |
Nosocomial infection | 40.21 | 12.31 | 20 | 29210 | 2812 | 79712346 |
Drug abuse | 39.90 | 12.31 | 6 | 29224 | 162685 | 79552473 |
Cataract operation complication | 39.74 | 12.31 | 11 | 29219 | 290 | 79714868 |
Respiratory tract infection bacterial | 39.70 | 12.31 | 18 | 29212 | 2059 | 79713099 |
Pneumonia | 38.97 | 12.31 | 391 | 28839 | 659855 | 79055303 |
Angioedema | 38.83 | 12.31 | 86 | 29144 | 75949 | 79639209 |
Pneumonia mycoplasmal | 38.71 | 12.31 | 16 | 29214 | 1462 | 79713696 |
Premature rupture of membranes | 38.71 | 12.31 | 22 | 29208 | 4047 | 79711111 |
Blood pressure decreased | 38.44 | 12.31 | 101 | 29129 | 99365 | 79615793 |
Drug interaction | 38.39 | 12.31 | 272 | 28958 | 414911 | 79300247 |
Premature delivery | 38.09 | 12.31 | 45 | 29185 | 23422 | 79691736 |
Lower respiratory tract infection bacterial | 37.98 | 12.31 | 14 | 29216 | 942 | 79714216 |
Lymphadenectomy | 37.69 | 12.31 | 15 | 29215 | 1244 | 79713914 |
Parophthalmia | 36.73 | 12.31 | 11 | 29219 | 386 | 79714772 |
Myocardial ischaemia | 36.65 | 12.31 | 46 | 29184 | 25473 | 79689685 |
Bronchial disorder | 36.60 | 12.31 | 18 | 29212 | 2471 | 79712687 |
Arthralgia | 36.55 | 12.31 | 99 | 29131 | 571704 | 79143454 |
Ischaemic cerebral infarction | 36.28 | 12.31 | 18 | 29212 | 2517 | 79712641 |
Fall | 36.23 | 12.31 | 78 | 29152 | 487551 | 79227607 |
Oesophageal carcinoma | 36.07 | 12.31 | 31 | 29199 | 11053 | 79704105 |
Musculoskeletal stiffness | 35.61 | 12.31 | 10 | 29220 | 174998 | 79540160 |
Death | 35.52 | 12.31 | 99 | 29131 | 566415 | 79148743 |
Anterior chamber fibrin | 35.51 | 12.31 | 9 | 29221 | 167 | 79714991 |
Intestinal intraepithelial lymphocytes increased | 35.31 | 12.31 | 9 | 29221 | 171 | 79714987 |
Increased bronchial secretion | 34.40 | 12.31 | 19 | 29211 | 3308 | 79711850 |
Airway peak pressure increased | 33.80 | 12.31 | 10 | 29220 | 336 | 79714822 |
Retinal disorder | 33.71 | 12.31 | 16 | 29214 | 2031 | 79713127 |
Pulmonary vasculitis | 33.42 | 12.31 | 12 | 29218 | 749 | 79714409 |
Stevens-Johnson syndrome | 33.26 | 12.31 | 55 | 29175 | 39111 | 79676047 |
Intestinal ischaemia | 33.16 | 12.31 | 32 | 29198 | 13238 | 79701920 |
Face oedema | 33.12 | 12.31 | 46 | 29184 | 28090 | 79687068 |
Immunosuppressant drug level increased | 33.00 | 12.31 | 27 | 29203 | 9000 | 79706158 |
Shock | 32.83 | 12.31 | 58 | 29172 | 43490 | 79671668 |
Erythema | 31.95 | 12.31 | 164 | 29066 | 223126 | 79492032 |
Fibrinolysis increased | 31.44 | 12.31 | 6 | 29224 | 26 | 79715132 |
Probiotic therapy | 31.39 | 12.31 | 8 | 29222 | 152 | 79715006 |
Brain injury | 31.12 | 12.31 | 29 | 29201 | 11488 | 79703670 |
Sputum increased | 31.11 | 12.31 | 20 | 29210 | 4593 | 79710565 |
Cryptitis | 30.81 | 12.31 | 9 | 29221 | 289 | 79714869 |
Sepsis | 30.64 | 12.31 | 186 | 29044 | 269242 | 79445916 |
Trimethylaminuria | 29.78 | 12.31 | 8 | 29222 | 188 | 79714970 |
Chest X-ray abnormal | 29.71 | 12.31 | 24 | 29206 | 7859 | 79707299 |
Eye inflammation | 29.56 | 12.31 | 22 | 29208 | 6391 | 79708767 |
Pain | 29.08 | 12.31 | 146 | 29084 | 703656 | 79011502 |
Fear | 29.01 | 12.31 | 38 | 29192 | 21948 | 79693210 |
Therapeutic product effect decreased | 28.78 | 12.31 | 12 | 29218 | 163851 | 79551307 |
Microvillous inclusion disease | 28.68 | 12.31 | 8 | 29222 | 217 | 79714941 |
Metabolic disorder | 28.53 | 12.31 | 25 | 29205 | 9145 | 79706013 |
Systemic lupus erythematosus | 28.51 | 12.31 | 5 | 29225 | 121144 | 79594014 |
Lack of spontaneous speech | 28.37 | 12.31 | 8 | 29222 | 226 | 79714932 |
Drug intolerance | 28.37 | 12.31 | 33 | 29197 | 264086 | 79451072 |
Vulval cancer metastatic | 27.65 | 12.31 | 4 | 29226 | 0 | 79715158 |
Treatment failure | 27.59 | 12.31 | 14 | 29216 | 170472 | 79544686 |
Disease complication | 27.49 | 12.31 | 19 | 29211 | 4918 | 79710240 |
Meningitis candida | 27.27 | 12.31 | 7 | 29223 | 137 | 79715021 |
Cardiac massage | 26.72 | 12.31 | 5 | 29225 | 19 | 79715139 |
Cutaneous vasculitis | 26.69 | 12.31 | 23 | 29207 | 8229 | 79706929 |
Apoptosis | 25.89 | 12.31 | 9 | 29221 | 511 | 79714647 |
Hypersensitivity vasculitis | 25.87 | 12.31 | 21 | 29209 | 6922 | 79708236 |
Joint hyperextension | 25.63 | 12.31 | 8 | 29222 | 323 | 79714835 |
Pericarditis | 25.20 | 12.31 | 4 | 29226 | 104232 | 79610926 |
Renal failure | 24.94 | 12.31 | 142 | 29088 | 200826 | 79514332 |
Boutonneuse fever | 24.88 | 12.31 | 4 | 29226 | 4 | 79715154 |
Gait disturbance | 24.42 | 12.31 | 24 | 29206 | 207482 | 79507676 |
Injury | 24.34 | 12.31 | 73 | 29157 | 77423 | 79637735 |
Toxic skin eruption | 24.10 | 12.31 | 35 | 29195 | 22258 | 79692900 |
Intentional product use issue | 23.86 | 12.31 | 13 | 29217 | 152099 | 79563059 |
Haemoptysis | 23.85 | 12.31 | 59 | 29171 | 55940 | 79659218 |
Neuritis | 23.74 | 12.31 | 12 | 29218 | 1746 | 79713412 |
Serratia infection | 23.62 | 12.31 | 12 | 29218 | 1764 | 79713394 |
Vitreous disorder | 23.15 | 12.31 | 7 | 29223 | 254 | 79714904 |
Bulimia nervosa | 23.12 | 12.31 | 7 | 29223 | 255 | 79714903 |
Serous retinal detachment | 23.11 | 12.31 | 10 | 29220 | 1024 | 79714134 |
Tachycardia | 22.98 | 12.31 | 127 | 29103 | 177641 | 79537517 |
Nephritis allergic | 22.91 | 12.31 | 9 | 29221 | 721 | 79714437 |
Cardiovascular insufficiency | 22.80 | 12.31 | 14 | 29216 | 2967 | 79712191 |
Oliguria | 22.78 | 12.31 | 29 | 29201 | 16280 | 79698878 |
Ascites | 22.63 | 12.31 | 70 | 29160 | 75492 | 79639666 |
Biopsy | 22.63 | 12.31 | 9 | 29221 | 745 | 79714413 |
Pain in extremity | 22.59 | 12.31 | 64 | 29166 | 364474 | 79350684 |
Labelled drug-drug interaction medication error | 22.37 | 12.31 | 38 | 29192 | 27612 | 79687546 |
Abdominal discomfort | 22.22 | 12.31 | 36 | 29194 | 250691 | 79464467 |
Escherichia infection | 22.02 | 12.31 | 30 | 29200 | 17987 | 79697171 |
Renal graft infection | 21.65 | 12.31 | 8 | 29222 | 542 | 79714616 |
Acute generalised exanthematous pustulosis | 21.50 | 12.31 | 29 | 29201 | 17225 | 79697933 |
Toxoplasmosis | 21.49 | 12.31 | 13 | 29217 | 2684 | 79712474 |
Endotracheal intubation | 21.39 | 12.31 | 16 | 29214 | 4681 | 79710477 |
Venous thrombosis | 21.34 | 12.31 | 19 | 29211 | 7097 | 79708061 |
Atheroembolism | 21.24 | 12.31 | 7 | 29223 | 337 | 79714821 |
Platelet count decreased | 21.24 | 12.31 | 24 | 29206 | 194640 | 79520518 |
Contraindicated product administered | 21.24 | 12.31 | 16 | 29214 | 157522 | 79557636 |
Exophthalmos | 21.02 | 12.31 | 11 | 29219 | 1719 | 79713439 |
Cardiac arrest | 20.95 | 12.31 | 121 | 29109 | 171975 | 79543183 |
Oesophageal spasm | 20.91 | 12.31 | 14 | 29216 | 3442 | 79711716 |
Retinal haemorrhage | 20.88 | 12.31 | 20 | 29210 | 8197 | 79706961 |
Antidiuretic hormone abnormality | 20.72 | 12.31 | 5 | 29225 | 75 | 79715083 |
Aspergillus infection | 20.59 | 12.31 | 30 | 29200 | 19131 | 79696027 |
Lip swelling | 20.57 | 12.31 | 46 | 29184 | 40865 | 79674293 |
Injection site pain | 20.50 | 12.31 | 11 | 29219 | 129827 | 79585331 |
Nasopharyngitis | 20.19 | 12.31 | 39 | 29191 | 253842 | 79461316 |
Insomnia | 20.08 | 12.31 | 37 | 29193 | 245133 | 79470025 |
Anhedonia | 20.04 | 12.31 | 26 | 29204 | 14872 | 79700286 |
Toxicity to various agents | 20.02 | 12.31 | 83 | 29147 | 421457 | 79293701 |
Delayed delivery | 20.02 | 12.31 | 4 | 29226 | 23 | 79715135 |
Vanishing twin syndrome | 19.98 | 12.31 | 5 | 29225 | 88 | 79715070 |
Optic atrophy | 19.88 | 12.31 | 11 | 29219 | 1922 | 79713236 |
Sepsis syndrome | 19.45 | 12.31 | 10 | 29220 | 1507 | 79713651 |
Transaminases increased | 19.43 | 12.31 | 52 | 29178 | 51691 | 79663467 |
Demyelination | 19.40 | 12.31 | 19 | 29211 | 8004 | 79707154 |
Delivery | 19.33 | 12.31 | 8 | 29222 | 734 | 79714424 |
Rotavirus infection | 19.33 | 12.31 | 8 | 29222 | 734 | 79714424 |
Discomfort | 19.32 | 12.31 | 11 | 29219 | 125606 | 79589552 |
Macular ischaemia | 19.28 | 12.31 | 5 | 29225 | 102 | 79715056 |
Hypopyon | 19.03 | 12.31 | 9 | 29221 | 1133 | 79714025 |
Wrong technique in product usage process | 19.02 | 12.31 | 65 | 29165 | 73810 | 79641348 |
Intraocular pressure increased | 18.97 | 12.31 | 20 | 29210 | 9185 | 79705973 |
Conjunctival oedema | 18.91 | 12.31 | 9 | 29221 | 1149 | 79714009 |
Clostridium test positive | 18.90 | 12.31 | 17 | 29213 | 6437 | 79708721 |
Rash | 18.83 | 12.31 | 307 | 28923 | 578051 | 79137107 |
Skin test positive | 18.80 | 12.31 | 9 | 29221 | 1165 | 79713993 |
Toxic anterior segment syndrome | 18.68 | 12.31 | 12 | 29218 | 2752 | 79712406 |
Acinetobacter infection | 18.63 | 12.31 | 12 | 29218 | 2765 | 79712393 |
Blood cholesterol increased | 18.55 | 12.31 | 4 | 29226 | 83716 | 79631442 |
Drug resistance | 18.53 | 12.31 | 45 | 29185 | 42168 | 79672990 |
Oesophageal pain | 18.22 | 12.31 | 14 | 29216 | 4265 | 79710893 |
Tubulointerstitial nephritis | 18.13 | 12.31 | 42 | 29188 | 38193 | 79676965 |
Emotional distress | 17.96 | 12.31 | 43 | 29187 | 39926 | 79675232 |
Acute hepatic failure | 17.61 | 12.31 | 36 | 29194 | 30077 | 79685081 |
Drug hypersensitivity | 17.54 | 12.31 | 177 | 29053 | 298739 | 79416419 |
Product preparation issue | 17.23 | 12.31 | 9 | 29221 | 1401 | 79713757 |
Cardiomegaly | 17.21 | 12.31 | 33 | 29197 | 26319 | 79688839 |
Retinopathy | 17.16 | 12.31 | 13 | 29217 | 3878 | 79711280 |
Hypotension | 17.13 | 12.31 | 241 | 28989 | 440076 | 79275082 |
Pruritus | 16.99 | 12.31 | 220 | 29010 | 394428 | 79320730 |
Intentional product misuse | 16.65 | 12.31 | 7 | 29223 | 95158 | 79620000 |
Mediastinal effusion | 16.58 | 12.31 | 4 | 29226 | 60 | 79715098 |
Natural killer cell count decreased | 16.58 | 12.31 | 4 | 29226 | 60 | 79715098 |
Arteriospasm coronary | 16.41 | 12.31 | 16 | 29214 | 6700 | 79708458 |
Mechanical ventilation | 16.25 | 12.31 | 11 | 29219 | 2753 | 79712405 |
Cardiopulmonary failure | 16.24 | 12.31 | 16 | 29214 | 6785 | 79708373 |
Deafness bilateral | 16.05 | 12.31 | 10 | 29220 | 2175 | 79712983 |
Klebsiella infection | 16.01 | 12.31 | 24 | 29206 | 15696 | 79699462 |
Hepatosplenomegaly | 15.86 | 12.31 | 15 | 29215 | 6054 | 79709104 |
Hypertension | 15.81 | 12.31 | 65 | 29165 | 330927 | 79384231 |
Bronchopneumopathy | 15.56 | 12.31 | 7 | 29223 | 786 | 79714372 |
Visual impairment | 15.55 | 12.31 | 71 | 29159 | 92060 | 79623098 |
Renal impairment | 15.49 | 12.31 | 105 | 29125 | 157678 | 79557480 |
Live birth | 15.48 | 12.31 | 26 | 29204 | 18718 | 79696440 |
Hydronephrosis | 15.48 | 12.31 | 25 | 29205 | 17429 | 79697729 |
Wound | 15.40 | 12.31 | 12 | 29218 | 116167 | 79598991 |
Coma blister | 15.27 | 12.31 | 5 | 29225 | 236 | 79714922 |
Drug-induced liver injury | 15.16 | 12.31 | 56 | 29174 | 66061 | 79649097 |
Haemorrhoids thrombosed | 15.03 | 12.31 | 5 | 29225 | 248 | 79714910 |
Linear IgA disease | 15.01 | 12.31 | 11 | 29219 | 3121 | 79712037 |
White blood cell count decreased | 14.90 | 12.31 | 29 | 29201 | 188259 | 79526899 |
Pneumonectomy | 14.89 | 12.31 | 4 | 29226 | 94 | 79715064 |
Acute pulmonary oedema | 14.89 | 12.31 | 22 | 29208 | 14208 | 79700950 |
Atelectasis | 14.82 | 12.31 | 35 | 29195 | 32222 | 79682936 |
Systemic infection | 14.68 | 12.31 | 18 | 29212 | 9734 | 79705424 |
Leukocytosis | 14.66 | 12.31 | 42 | 29188 | 43413 | 79671745 |
Cyanosis | 14.60 | 12.31 | 30 | 29200 | 25152 | 79690006 |
Dyspnoea | 14.59 | 12.31 | 414 | 28816 | 856611 | 78858547 |
Bladder neck obstruction | 14.47 | 12.31 | 4 | 29226 | 105 | 79715053 |
Genitourinary tract infection | 14.45 | 12.31 | 5 | 29225 | 280 | 79714878 |
Lymphangitis | 14.44 | 12.31 | 8 | 29222 | 1400 | 79713758 |
Blindness | 14.37 | 12.31 | 32 | 29198 | 28351 | 79686807 |
Product monitoring error | 14.32 | 12.31 | 17 | 29213 | 8889 | 79706269 |
Headache | 14.31 | 12.31 | 162 | 29068 | 653610 | 79061548 |
Motor dysfunction | 14.31 | 12.31 | 22 | 29208 | 14711 | 79700447 |
Pneumococcal infection | 14.30 | 12.31 | 7 | 29223 | 951 | 79714207 |
Pneumonia klebsiella | 14.18 | 12.31 | 13 | 29217 | 5041 | 79710117 |
Brain compression | 14.18 | 12.31 | 6 | 29224 | 582 | 79714576 |
Urticaria contact | 14.04 | 12.31 | 3 | 29227 | 25 | 79715133 |
Anti factor V antibody positive | 14.04 | 12.31 | 3 | 29227 | 25 | 79715133 |
Inappropriate schedule of product administration | 14.01 | 12.31 | 17 | 29213 | 133611 | 79581547 |
Blood pressure increased | 13.91 | 12.31 | 36 | 29194 | 211324 | 79503834 |
Weight decreased | 13.88 | 12.31 | 75 | 29155 | 355123 | 79360035 |
Blood glucose increased | 13.87 | 12.31 | 13 | 29217 | 114962 | 79600196 |
Erosive duodenitis | 13.84 | 12.31 | 9 | 29221 | 2108 | 79713050 |
Neuropathy peripheral | 13.76 | 12.31 | 19 | 29211 | 141286 | 79573872 |
Moraxella infection | 13.71 | 12.31 | 6 | 29224 | 631 | 79714527 |
HER2 positive breast cancer | 13.61 | 12.31 | 5 | 29225 | 333 | 79714825 |
Eosinophilia | 13.57 | 12.31 | 42 | 29188 | 45303 | 79669855 |
Fluid intake reduced | 13.56 | 12.31 | 14 | 29216 | 6274 | 79708884 |
Cholestasis | 13.54 | 12.31 | 46 | 29184 | 52063 | 79663095 |
Contusion | 13.51 | 12.31 | 21 | 29209 | 148755 | 79566403 |
Anaphylactoid reaction | 13.41 | 12.31 | 13 | 29217 | 5409 | 79709749 |
Rash erythematous | 13.30 | 12.31 | 49 | 29181 | 57720 | 79657438 |
Scoliosis | 13.26 | 12.31 | 15 | 29215 | 7449 | 79707709 |
B-lymphocyte count increased | 13.18 | 12.31 | 4 | 29226 | 147 | 79715011 |
Mucosal erosion | 13.09 | 12.31 | 9 | 29221 | 2309 | 79712849 |
Drug level increased | 13.07 | 12.31 | 38 | 29192 | 39613 | 79675545 |
Respiratory failure | 13.05 | 12.31 | 112 | 29118 | 180799 | 79534359 |
Amaurosis | 12.86 | 12.31 | 7 | 29223 | 1184 | 79713974 |
Peripheral swelling | 12.84 | 12.31 | 53 | 29177 | 269564 | 79445594 |
Cerebral ischaemia | 12.72 | 12.31 | 18 | 29212 | 11177 | 79703981 |
Cholestatic liver injury | 12.51 | 12.31 | 12 | 29218 | 4929 | 79710229 |
Decreased appetite | 12.46 | 12.31 | 74 | 29156 | 342344 | 79372814 |
Pupillary block | 12.37 | 12.31 | 3 | 29227 | 46 | 79715112 |
None
Source | Code | Description |
---|---|---|
ATC | J01DC02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Second-generation cephalosporins |
ATC | J01RA03 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE COMBINATIONS OF ANTIBACTERIALS Combinations of antibacterials |
ATC | S01AA27 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics |
FDA CS | M0003827 | Cephalosporins |
FDA EPC | N0000175488 | Cephalosporin Antibacterial |
CHEBI has role | CHEBI:88188 | allergenic drug |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Acute otitis media | indication | 3110003 | |
Streptococcal meningitis | indication | 4510004 | DOID:11574 |
Septicemia due to Escherichia coli | indication | 9323009 | |
Bacterial septicemia | indication | 10001005 | DOID:0040085 |
Staphylococcal meningitis | indication | 12166008 | |
Gonorrhea | indication | 15628003 | DOID:7551 |
Haemophilus Influenzae Acute Otitis Media | indication | 19021002 | |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Acute gonococcal cervicitis | indication | 20943002 | DOID:10615 |
Staphylococcal pneumonia | indication | 22754005 | |
Lyme disease | indication | 23502006 | DOID:11729 |
Streptococcal septicemia | indication | 29577008 | |
Acute gonococcal urethritis | indication | 29864006 | |
Pneumonia due to Streptococcus | indication | 34020007 | |
Streptococcal tonsillitis | indication | 41582007 | |
Gonorrhea of rectum | indication | 42746002 | |
Impetigo | indication | 48277006 | DOID:8504 |
Lower respiratory tract infection | indication | 50417007 | |
Pneumonia due to Escherichia coli | indication | 51530003 | |
Bacterial pneumonia | indication | 53084003 | DOID:874 |
Klebsiella cystitis | indication | 60867007 | |
Acute gonococcal endometritis | indication | 65295003 | DOID:7527 |
Acute maxillary sinusitis | indication | 68272006 | DOID:2050 |
Haemophilus influenzae pneumonia | indication | 70036007 | |
Infection due to Escherichia coli | indication | 71057007 | |
Rhinoscleroma | indication | 72409005 | DOID:11336 |
Gonorrhea of pharynx | indication | 74372003 | |
Acute bacterial sinusitis | indication | 75498004 | |
Bacterial meningitis | indication | 95883001 | DOID:9470 |
Infection of bone | indication | 111253001 | |
Staphylococcal septicemia | indication | 111821004 | |
Infection due to Enterobacteriaceae | indication | 128945009 | |
Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
Escherichia coli urinary tract infection | indication | 301011002 | |
Streptococcus pyogenes infection | indication | 302809008 | |
Bacterial urinary infection | indication | 312124009 | |
Infective otitis media | indication | 312218008 | |
Infectious disorder of joint | indication | 363162000 | |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Acute exacerbation of chronic bronchitis | indication | 425748003 | |
Osteomyelitis due to Staphylococcus aureus | indication | 428783003 | |
Moraxella Catarrhalis Acute Otitis Media | indication | 703469002 | |
Haemophilus Influenzae Bronchitis | indication | ||
Streptococcus Pneumoniae Chronic Bronchitis | indication | ||
Disseminated Gonococcal Infection | indication | ||
Streptococcus Pneumoniae Bronchitis | indication | ||
Haemophilus Parainfluenzae Bronchitis | indication | ||
Staphylococcus Aureus Joint Infection | indication | ||
H. Influenzae Meningitis | indication | ||
Prevention of Perioperative Infection | indication | ||
Haemophilus Influenzae Chronic Bronchitis | indication | ||
Haemophilus Septicemia | indication | ||
Haemophilus Parainfluenzae Chronic Bronchitis | indication | ||
Open Heart Surgery Infection Prevention | indication | ||
Pyrexia of unknown origin | off-label use | 7520000 | |
Sepsis of the newborn | off-label use | 206376005 | |
Neonatal pneumonia | off-label use | 233619008 | |
Neonatal meningitis | off-label use | 276674008 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Factor II deficiency | contraindication | 73975000 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pseudomembranous enterocolitis | contraindication | 397683000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.32 | acidic |
pKa2 | 13.33 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Carbonic anhydrase 2 | Enzyme | IC50 | 5.92 | WOMBAT-PK | |||||
72 kDa type IV collagenase | Enzyme | IC50 | 4.37 | WOMBAT-PK | |||||
Matrix metalloproteinase-9 | Enzyme | IC50 | 4.96 | WOMBAT-PK | |||||
Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
Penicillin-binding protein 1A | Enzyme | WOMBAT-PK |
ID | Source |
---|---|
4019668 | VUID |
N0000147760 | NUI |
D00262 | KEGG_DRUG |
56238-63-2 | SECONDARY_CAS_RN |
204144 | RXNORM |
C0007562 | UMLSCUI |
CHEBI:3515 | CHEBI |
KOV | PDB_CHEM_ID |
CHEMBL2146124 | ChEMBL_ID |
CHEMBL1436 | ChEMBL_ID |
D002444 | MESH_DESCRIPTOR_UI |
DB01112 | DRUGBANK_ID |
5479529 | PUBCHEM_CID |
10900 | IUPHAR_LIGAND_ID |
3902 | INN_ID |
O1R9FJ93ED | UNII |
2973 | MMSL |
4389 | MMSL |
d00056 | MMSL |
002731 | NDDF |
003590 | NDDF |
372833007 | SNOMEDCT_US |
48753004 | SNOMEDCT_US |
73986003 | SNOMEDCT_US |
4017551 | VANDF |
4019668 | VANDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Cefuroxime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9567 | INJECTION, POWDER, FOR SOLUTION | 1.50 g | INTRAVENOUS | ANDA | 23 sections |
Cefuroxime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9567 | INJECTION, POWDER, FOR SOLUTION | 1.50 g | INTRAVENOUS | ANDA | 23 sections |
Cefuroxime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9568 | INJECTION, POWDER, FOR SOLUTION | 750 mg | INTRAMUSCULAR | ANDA | 23 sections |
Cefuroxime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9568 | INJECTION, POWDER, FOR SOLUTION | 750 mg | INTRAMUSCULAR | ANDA | 23 sections |
Cefuroxime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9569 | INJECTION, POWDER, FOR SOLUTION | 7.50 g | INTRAVENOUS | ANDA | 24 sections |
Cefuroxime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9976 | INJECTION, POWDER, FOR SOLUTION | 750 mg | INTRAVENOUS | ANDA | 24 sections |
Cefuroxime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9976 | INJECTION, POWDER, FOR SOLUTION | 750 mg | INTRAVENOUS | ANDA | 24 sections |
Cefuroxime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9977 | INJECTION, POWDER, FOR SOLUTION | 1.50 g | INTRAVENOUS | ANDA | 22 sections |
Cefuroxime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9977 | INJECTION, POWDER, FOR SOLUTION | 1.50 g | INTRAVENOUS | ANDA | 22 sections |
Cefuroxime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9979 | INJECTION, POWDER, FOR SOLUTION | 750 mg | INTRAMUSCULAR | ANDA | 22 sections |
Cefuroxime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9979 | INJECTION, POWDER, FOR SOLUTION | 750 mg | INTRAMUSCULAR | ANDA | 22 sections |
Cefuroxime and Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3112 | INJECTION, SOLUTION | 750 mg | INTRAVENOUS | NDA | 24 sections |
Cefuroxime and Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3114 | INJECTION, SOLUTION | 1.50 g | INTRAVENOUS | NDA | 24 sections |
Cefuroxime sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-118 | INJECTION, POWDER, FOR SOLUTION | 750 mg | INTRAVENOUS | ANDA | 25 sections |
Cefuroxime sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-119 | INJECTION, POWDER, FOR SOLUTION | 1.50 g | INTRAVENOUS | ANDA | 25 sections |
Cefuroxime sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-182 | INJECTION, POWDER, FOR SOLUTION | 750 mg | INTRAVENOUS | ANDA | 26 sections |
Cefuroxime sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-183 | INJECTION, POWDER, FOR SOLUTION | 1.50 g | INTRAVENOUS | ANDA | 26 sections |
Cefuroxime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-710 | INJECTION, POWDER, FOR SOLUTION | 750 mg | INTRAMUSCULAR | ANDA | 24 sections |
Cefuroxime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-711 | INJECTION, POWDER, FOR SOLUTION | 1.50 g | INTRAVENOUS | ANDA | 24 sections |
Cefuroxime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-712 | INJECTION, POWDER, FOR SOLUTION | 7.50 g | INTRAVENOUS | ANDA | 25 sections |
Cefuroxime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-720 | INJECTION, POWDER, FOR SOLUTION | 750 mg | INTRAVENOUS | ANDA | 24 sections |
Cefuroxime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-722 | INJECTION, POWDER, FOR SOLUTION | 1.50 g | INTRAVENOUS | ANDA | 24 sections |