ceftezole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 561 26973-24-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ceftezole
  • ceftezol
  • ceftezole sodium
  • demethylcefazolin
  • demethyl cefazolin
  • Molecular weight: 440.47
  • Formula: C13H12N8O4S3
  • CLOGP: -1.08
  • LIPINSKI: 1
  • HAC: 12
  • HDO: 2
  • TPSA: 156.09
  • ALOGS: -2.71
  • ROTB: 7

Drug dosage:

DoseUnitRoute
3 g P

ADMET properties:

PropertyValueReference
CL (Clearance) 5.37 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.64 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -2.293 High 0.82
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.265 High 0.82
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.561 10^-6 cm/s High 0.82
dh-clint Dog hepatocyte intrinsic clearance 1.202 uL/min/10^6 cells High 0.82
dppb Dog plasma protein binding (% unbound) 70.430 % High 0.82
fcs-ppb Fetal calf serum protein binding (% unbound) 56.360 % High 0.82
herg hERG pIC50 4.469 pIC50 High 0.82
hh-clint Human hepatocyte intrinsic clearance 1.626 uL/min/10^6 cells High 0.82
hlm-clint Human liver microsomal intrinsic clearance 4.603 uL/min/mg protein High 0.82
hppb Human plasma protein binding (% unbound) 44.610 % High 0.82
kinase-safety-class ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,GRK2,GRK3,ITK,JAK2,MAP3K21,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PIK3CB,PIK3CD,PRKDC,STK33,SYK,TEK,TTK 29
kinase-selectivity-class CDK9,EIF2AK3,GRK2,MAP2K6,MAPK7 5
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.042 High 0.82
mh-clint Mouse hepatocyte intrinsic clearance 2.500 High 0.82
mppb Mouse plasma protein binding (% unbound) 57.480 High 0.82
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.637 High 0.82
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 35.730 % High 0.82
rh-clint Rat hepatocyte intrinsic clearance 1.545 uL/min/10^6 cells High 0.82
rh-fuinc Rat hepatocyte fraction unbound in incubation 87.520 % High 0.82
rppb Rat plasma protein binding (% unbound) 30.730 % High 0.82
solubility-dd Solubility at pH 7.4 in DMSO 968.278 uM High 0.82

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01DB12 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
First-generation cephalosporins
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
CHEBI has role CHEBI:33282 antibacterial agent

Related Drugs by ATC class:

J01DB First-generation cephalosporins 11 drugs
cefacetrilecefadroxilcefalexincefaloridinecefalotincefapirincefatrizinecefazedonecefazolincefradinecefroxadine

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.07 acidic
pKa2 12.21 acidic
pKa3 1.13 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07656 KEGG_DRUG
C0055013 UMLSCUI
CHEBI:135716 CHEBI
CHEMBL1697829 ChEMBL_ID
DB13821 DRUGBANK_ID
C012811 MESH_SUPPLEMENTAL_RECORD_UI
12259 IUPHAR_LIGAND_ID
3914 INN_ID
2Z86SYP11W UNII
65755 PUBCHEM_CID
010924 NDDF
010925 NDDF
41136-22-5 SECONDARY_CAS_RN

Pharmaceutical products:

None