cefazolin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 530 25953-19-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cefazolin
  • cefazolin sodium
  • cefamezin
  • cefaprim
  • cefazoline
  • cephamezine
  • cephazolin
  • cephazoline
  • cefazolin sodium salt
A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
  • Molecular weight: 454.50
  • Formula: C14H14N8O4S3
  • CLOGP: -0.64
  • LIPINSKI: 1
  • HAC: 12
  • HDO: 2
  • TPSA: 156.09
  • ALOGS: -2.97
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
3 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 33 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 80 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 146.75 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 0 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.12 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.89 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.18 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.70 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -2.184 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.104 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.740 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 1.213 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 63.150 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 48.450 % High 1
herg hERG pIC50 4.505 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 1.675 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 4.487 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 35.250 % High 1
kinase-safety-class ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,GRK2,GRK3,ITK,JAK2,MAP3K21,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDPK1,PIK3CB,PIK3CD,PRKDC,STK33,SYK,TEK,TTK 30
kinase-selectivity-class EIF2AK3,GRK2,MAP2K6,MAPK7,PRKDC,TEK 6
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.050 High 1
mh-clint Mouse hepatocyte intrinsic clearance 1.726 High 1
mppb Mouse plasma protein binding (% unbound) 48.560 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.690 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 27.680 % High 1
rh-clint Rat hepatocyte intrinsic clearance 1.208 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 86.430 % High 1
rppb Rat plasma protein binding (% unbound) 26.190 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 984.011 uM High 1

Approvals:

DateAgencyCompanyOrphan
Oct. 4, 1973 FDA GLAXOSMITHKLINE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic shock 961.24 14.01 331 19357 31286 90577473
Anaphylactic reaction 551.39 14.01 301 19387 87223 90521536
Acute generalised exanthematous pustulosis 290.33 14.01 110 19578 13593 90595166
Hypotension 285.80 14.01 352 19336 325045 90283714
Arthrodesis 158.89 14.01 48 19640 2964 90605795
Bronchospasm 152.03 14.01 79 19609 20630 90588129
Cardiac arrest 117.67 14.01 129 19559 104806 90503953
Postoperative wound infection 115.43 14.01 57 19631 13369 90595390
Tachycardia 109.10 14.01 152 19536 157521 90451238
Premature delivery 101.95 14.01 77 19611 38685 90570074
Erythema 101.52 14.01 180 19508 229066 90379693
Clostridium test positive 95.36 14.01 38 19650 5363 90603396
Hypoprothrombinaemia 93.57 14.01 21 19667 394 90608365
Fatigue 87.21 14.01 74 19614 1153949 89454810
Maternal exposure during delivery 81.88 14.01 31 19657 3815 90604944
Type I hypersensitivity 79.56 14.01 31 19657 4124 90604635
Vitamin K deficiency 68.85 14.01 17 19671 488 90608271
Blood pressure decreased 68.63 14.01 83 19605 74812 90533947
Procedural hypotension 65.49 14.01 21 19667 1579 90607180
Exposure during pregnancy 64.78 14.01 153 19535 238257 90370502
Urticaria 64.63 14.01 181 19507 312553 90296206
Bradycardia 64.26 14.01 85 19603 83762 90524997
Alopecia 63.22 14.01 15 19673 495056 90113703
Drug reaction with eosinophilia and systemic symptoms 63.16 14.01 61 19627 42697 90566062
Drug intolerance 62.45 14.01 11 19677 447580 90161179
Shoulder arthroplasty 62.23 14.01 26 19662 4140 90604619
Linear IgA disease 62.02 14.01 22 19666 2252 90606507
Premature baby 61.94 14.01 48 19640 25029 90583730
Toxic skin eruption 61.75 14.01 40 19648 15734 90593025
Systemic lupus erythematosus 59.98 14.01 5 19683 361891 90246868
Amniotic cavity infection 59.93 14.01 19 19669 1377 90607382
Generalised tonic-clonic seizure 59.65 14.01 54 19634 34849 90573910
Renal failure 59.38 14.01 104 19584 130903 90477856
Coagulopathy 58.45 14.01 45 19643 23244 90585515
Limb operation 56.89 14.01 25 19663 4502 90604257
Rash 56.80 14.01 330 19358 795770 89812989
Angioedema 56.37 14.01 70 19618 64806 90543953
Circulatory collapse 53.67 14.01 44 19644 24860 90583899
Wound 53.66 14.01 3 19685 302977 90305782
Toxic epidermal necrolysis 51.07 14.01 48 19640 32480 90576279
Eosinophilia 50.44 14.01 45 19643 28488 90580271
Joint swelling 49.13 14.01 24 19664 503276 90105483
Weight increased 48.93 14.01 15 19673 417912 90190847
Kounis syndrome 48.71 14.01 19 19669 2534 90606225
Vascular purpura 48.11 14.01 17 19671 1721 90607038
Renal injury 47.70 14.01 29 19659 10214 90598545
Pericarditis 46.85 14.01 3 19685 270148 90338611
Anaesthetic complication 45.81 14.01 18 19670 2447 90606312
Oxygen saturation decreased 45.71 14.01 83 19605 107400 90501359
Recurrence of neuromuscular blockade 44.43 14.01 10 19678 190 90608569
Disseminated intravascular coagulation 44.22 14.01 37 19651 21501 90587258
Infusion related reaction 43.60 14.01 18 19670 416762 90191997
Drug hypersensitivity 43.13 14.01 207 19481 463402 90145357
Clostridium difficile colitis 43.06 14.01 40 19648 26666 90582093
Multiple organ dysfunction syndrome 42.97 14.01 63 19625 68273 90540486
Peripheral swelling 42.96 14.01 18 19670 413088 90195671
Sinusitis 42.59 14.01 11 19677 343077 90265682
Hepatic cytolysis 41.74 14.01 42 19646 30874 90577885
Stress cardiomyopathy 40.68 14.01 29 19659 13326 90595433
Acute kidney injury 39.70 14.01 156 19532 320231 90288528
Headache 39.61 14.01 80 19608 862666 89746093
Fear 39.28 14.01 31 19657 16591 90592168
Foetal exposure during delivery 38.05 14.01 10 19678 370 90608389
Post procedural complication 37.62 14.01 32 19656 19010 90589749
Anhedonia 37.56 14.01 26 19662 11405 90597354
Acute hepatic failure 36.78 14.01 34 19654 22527 90586232
Unevaluable event 36.58 14.01 52 19636 54796 90553963
Swelling 36.51 14.01 23 19665 419035 90189724
Thrombotic microangiopathy 36.43 14.01 29 19659 15714 90593045
Face oedema 35.82 14.01 34 19654 23284 90585475
Product dose omission issue 34.98 14.01 10 19678 291677 90317082
Nasopharyngitis 34.57 14.01 23 19665 407081 90201678
Tarsal tunnel syndrome 33.92 14.01 10 19678 567 90608192
Fibromyalgia 33.74 14.01 3 19685 206266 90402493
Drug-induced liver injury 33.74 14.01 66 19622 90252 90518507
Rash maculo-papular 33.69 14.01 43 19645 40890 90567869
Treatment failure 33.64 14.01 12 19676 303916 90304843
Foetal exposure during pregnancy 33.58 14.01 44 19644 42931 90565828
Purpura senile 33.29 14.01 10 19678 605 90608154
Musculoskeletal stiffness 32.32 14.01 12 19676 296520 90312239
Myocardial calcification 32.32 14.01 8 19680 232 90608527
Gastrointestinal disorder 32.29 14.01 8 19680 256679 90352080
Pain 32.28 14.01 110 19578 996231 89612528
Isoimmune haemolytic disease 32.27 14.01 6 19682 41 90608718
Pseudomembranous colitis 31.99 14.01 16 19672 3852 90604907
Mobility decreased 31.18 14.01 8 19680 250726 90358033
Lower respiratory tract infection 31.17 14.01 8 19680 250651 90358108
Device related infection 31.14 14.01 33 19655 25753 90583006
Pleural effusion 30.51 14.01 72 19616 111919 90496840
Renal cortical necrosis 30.47 14.01 8 19680 295 90608464
Hepatic enzyme increased 29.80 14.01 21 19667 360715 90248044
Cholestasis 29.67 14.01 38 19650 36261 90572498
Hepatic function abnormal 29.57 14.01 43 19645 46245 90562514
Encephalopathy 29.46 14.01 43 19645 46401 90562358
Lip oedema 29.25 14.01 16 19672 4623 90604136
Glomerular filtration rate abnormal 29.21 14.01 11 19677 1334 90607425
Mixed liver injury 29.02 14.01 19 19669 7604 90601155
Malaise 28.89 14.01 52 19636 585934 90022825
Folliculitis 28.52 14.01 5 19683 204348 90404411
Hypoxia 28.38 14.01 54 19634 72345 90536414
Impaired healing 28.12 14.01 8 19680 234191 90374568
Hypoaesthesia 27.69 14.01 17 19671 314193 90294566
Sepsis 27.68 14.01 94 19594 179720 90429039
Therapeutic product effect decreased 27.41 14.01 13 19675 277558 90331201
Acute febrile neutrophilic dermatosis 27.38 14.01 14 19674 3531 90605228
Heparin-induced thrombocytopenia 27.23 14.01 16 19672 5296 90603463
Hypokalaemia 27.13 14.01 76 19612 131040 90477719
Hepatitis cholestatic 27.02 14.01 19 19669 8542 90600217
Pain in extremity 26.98 14.01 35 19653 450494 90158265
Arthropathy 26.88 14.01 24 19664 366218 90242541
Cerebral infarction 26.87 14.01 31 19657 26565 90582194
Ventricular fibrillation 26.52 14.01 23 19665 14021 90594738
Caesarean section 26.48 14.01 26 19662 18551 90590208
Skin test negative 26.42 14.01 5 19683 38 90608721
Pulseless electrical activity 26.30 14.01 19 19669 8913 90599846
Emotional distress 26.29 14.01 36 19652 36626 90572133
International normalised ratio increased 26.03 14.01 41 19647 47275 90561484
Hyperthermia malignant 25.97 14.01 10 19678 1288 90607471
Haemolytic anaemia 25.90 14.01 21 19667 11676 90597083
Asthenia 25.74 14.01 48 19640 533703 90075056
Circumoral oedema 25.69 14.01 7 19681 298 90608461
Foetal anaemia 25.65 14.01 6 19682 136 90608623
Post procedural haematoma 25.43 14.01 10 19678 1362 90607397
Arthralgia 25.14 14.01 86 19602 778436 89830323
Sinus tachycardia 25.13 14.01 31 19657 28482 90580277
Intentional product use issue 24.97 14.01 8 19680 216884 90391875
Drug interaction 24.62 14.01 122 19566 276331 90332428
Tongue oedema 24.27 14.01 15 19673 5439 90603320
Altered state of consciousness 24.19 14.01 32 19656 31500 90577259
Migraine 23.81 14.01 6 19682 190386 90418373
Haemodynamic instability 23.75 14.01 20 19668 11719 90597040
Documented hypersensitivity to administered product 23.70 14.01 8 19680 706 90608053
Anuria 23.51 14.01 22 19666 14796 90593963
Shock 23.32 14.01 30 19658 28748 90580011
Tonic clonic movements 23.24 14.01 10 19678 1712 90607047
Implant site infection 23.22 14.01 9 19679 1180 90607579
Memory impairment 23.20 14.01 7 19681 197237 90411522
Multiple lentigines syndrome 23.18 14.01 6 19682 209 90608550
Resorption bone increased 23 14.01 9 19679 1210 90607549
Implant site haematoma 22.97 14.01 5 19683 81 90608678
Death 22.95 14.01 40 19648 456511 90152248
Alanine aminotransferase increased 22.93 14.01 67 19621 118271 90490488
Respiratory failure 22.90 14.01 67 19621 118351 90490408
Septic shock 22.80 14.01 54 19634 84106 90524653
Aspartate aminotransferase increased 22.61 14.01 61 19627 102876 90505883
Allergic stomatitis 22.30 14.01 3 19685 0 90608759
Eyelid oedema 22.01 14.01 19 19669 11515 90597244
Insomnia 21.99 14.01 24 19664 333450 90275309
Gait inability 21.75 14.01 3 19685 146453 90462306
Anaphylactoid reaction 21.71 14.01 13 19675 4455 90604304
Anaemia 21.70 14.01 141 19547 352661 90256098
Asthma 21.47 14.01 13 19675 242147 90366612
Vestibular disorder 20.92 14.01 9 19679 1540 90607219
Bacteraemia 20.88 14.01 25 19663 22275 90586484
Stridor 20.86 14.01 13 19675 4780 90603979
Deep vein thrombosis 20.84 14.01 55 19633 91565 90517194
Procedural complication 20.81 14.01 14 19674 5864 90602895
Urticarial vasculitis 20.73 14.01 8 19680 1037 90607722
Prothrombin time prolonged 20.50 14.01 17 19671 9755 90599004
Product use issue 20.40 14.01 25 19663 329894 90278865
Muscle spasms 20.35 14.01 15 19673 251868 90356891
Contusion 20.24 14.01 15 19673 251201 90357558
Post procedural haemorrhage 19.91 14.01 16 19672 8782 90599977
Hypoventilation 19.68 14.01 13 19675 5283 90603476
Delivery 19.65 14.01 9 19679 1784 90606975
Joint range of motion decreased 19.63 14.01 3 19685 135640 90473119
Clostridium difficile infection 19.37 14.01 31 19657 36214 90572545
Weight decreased 19.34 14.01 33 19655 379877 90228882
Airway peak pressure increased 19.24 14.01 6 19682 412 90608347
Diabetic retinal oedema 19.18 14.01 6 19682 416 90608343
Pyroglutamic acidosis 19.15 14.01 8 19680 1272 90607487
Shock haemorrhagic 19.08 14.01 18 19670 12227 90596532
Dizziness 19.06 14.01 65 19623 589219 90019540
Pyomyositis 19.03 14.01 6 19682 427 90608332
Airway complication of anaesthesia 18.99 14.01 6 19682 430 90608329
Injection site pain 18.97 14.01 7 19681 173692 90435067
Diabetic retinopathy 18.94 14.01 10 19678 2692 90606067
Discomfort 18.92 14.01 19 19669 274316 90334443
Low birth weight baby 18.89 14.01 16 19672 9451 90599308
Poor sucking reflex 18.87 14.01 6 19682 439 90608320
General physical health deterioration 18.87 14.01 30 19658 355085 90253674
Bursitis 18.85 14.01 3 19685 131651 90477108
Endocarditis staphylococcal 18.84 14.01 6 19682 441 90608318
Laryngeal oedema 18.82 14.01 14 19674 6867 90601892
Manipulation 18.79 14.01 4 19684 58 90608701
Blood cholesterol increased 18.68 14.01 11 19677 208001 90400758
Mycobacterial peritonitis 18.60 14.01 4 19684 61 90608698
Tachypnoea 18.51 14.01 23 19665 21286 90587473
Oligohydramnios 18.25 14.01 14 19674 7187 90601572
Laryngeal dyspnoea 18.08 14.01 5 19683 225 90608534
Spinal cord haematoma 18.06 14.01 5 19683 226 90608533
Allergy test negative 17.93 14.01 5 19683 232 90608527
Renal impairment 17.91 14.01 57 19631 105364 90503395
Staphylococcal bacteraemia 17.80 14.01 14 19674 7455 90601304
Electrocardiogram PR shortened 17.72 14.01 6 19682 535 90608224
Cardio-respiratory arrest 17.63 14.01 41 19647 63099 90545660
Peritonitis bacterial 17.55 14.01 12 19676 5159 90603600
Atelectasis 17.55 14.01 24 19664 24385 90584374
Tryptase increased 17.44 14.01 6 19682 561 90608198
Bradycardia foetal 17.33 14.01 6 19682 572 90608187
Abdominal wound dehiscence 17.20 14.01 5 19683 270 90608489
Jaundice acholuric 17.05 14.01 4 19684 92 90608667
Gamma-glutamyltransferase increased 17.01 14.01 30 19658 37922 90570837
Apnoea 16.94 14.01 15 19673 9399 90599360
Stevens-Johnson syndrome 16.91 14.01 26 19662 29350 90579409
Stomatitis 16.78 14.01 21 19667 274677 90334082
Inflammation 16.67 14.01 9 19679 178583 90430176
Blood creatinine increased 16.48 14.01 54 19634 101332 90507427
Therapeutic product effect incomplete 16.38 14.01 11 19677 193885 90414874
Episcleritis 16.35 14.01 7 19681 1183 90607576
Night sweats 16.21 14.01 4 19684 128762 90479997
Posterior reversible encephalopathy syndrome 16.11 14.01 22 19666 22317 90586442
Eosinophilic pneumonia acute 16.08 14.01 6 19682 709 90608050
Decorticate posture 16.08 14.01 5 19683 340 90608419
Cardiogenic shock 16.02 14.01 23 19665 24445 90584314
Adverse drug reaction 15.96 14.01 3 19685 116698 90492061
Cataract subcapsular 15.95 14.01 6 19682 725 90608034
Infantile apnoea 15.82 14.01 7 19681 1280 90607479
Macular oedema 15.74 14.01 11 19677 4898 90603861
Extradural abscess 15.74 14.01 7 19681 1297 90607462
Arthrofibrosis 15.72 14.01 3 19685 24 90608735
Loss of personal independence in daily activities 15.70 14.01 5 19683 136100 90472659
Blood chloride decreased 15.39 14.01 12 19676 6307 90602452
Lip swelling 15.37 14.01 29 19659 38581 90570178
Chorea 15.34 14.01 8 19680 2102 90606657
Staphylococcal infection 15.25 14.01 33 19655 48406 90560353
Irregular breathing 15.24 14.01 5 19683 404 90608355
Hypertensive crisis 15.13 14.01 19 19669 17765 90590994
Decreased ventricular preload 15.12 14.01 3 19685 30 90608729
Inappropriate schedule of product administration 14.83 14.01 7 19681 149926 90458833
Endotracheal intubation complication 14.76 14.01 5 19683 446 90608313
Immediate post-injection reaction 14.62 14.01 5 19683 459 90608300
Drug eruption 14.61 14.01 27 19661 35380 90573379
Cholelithiasis 14.55 14.01 34 19654 52472 90556287
Psoriasis 14.45 14.01 7 19681 147747 90461012
Pancytopenia 14.41 14.01 58 19630 120205 90488554
Serratia test positive 14.40 14.01 3 19685 39 90608720
Tinea pedis 14.38 14.01 7 19681 1590 90607169
Vertigo positional 14.38 14.01 9 19679 3335 90605424
Hypopnoea 14.37 14.01 10 19678 4421 90604338
Postpartum haemorrhage 14.37 14.01 8 19680 2393 90606366
Diarrhoea 14.25 14.01 133 19555 939057 89669702
Status epilepticus 14.24 14.01 19 19669 18855 90589904
Endocarditis 14.15 14.01 12 19676 7101 90601658
Musculoskeletal pain 14.08 14.01 10 19678 171241 90437518
Cutaneous vasculitis 14.03 14.01 12 19676 7181 90601578

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic shock 686.94 14.54 287 17942 23230 42579876
Anaphylactic reaction 487.88 14.54 274 17955 42469 42560637
Lymphoid tissue hypoplasia 185.27 14.54 48 18181 830 42602276
Thymus hypoplasia 181.28 14.54 47 18182 815 42602291
Hypoprothrombinaemia 171.47 14.54 40 18189 436 42602670
Drug reaction with eosinophilia and systemic symptoms 139.49 14.54 127 18102 41948 42561158
Disseminated aspergillosis 132.47 14.54 43 18186 1687 42601419
Kounis syndrome 128.86 14.54 50 18179 3318 42599788
Hypotension 124.05 14.54 312 17917 257319 42345787
Clostridium difficile colitis 123.32 14.54 89 18140 21163 42581943
Urticaria 104.60 14.54 143 18086 73893 42529213
Fear 90.13 14.54 57 18172 10908 42592198
Clostridium test positive 87.23 14.54 44 18185 5461 42597645
Fatigue 82.33 14.54 42 18187 435599 42167507
Bronchospasm 81.75 14.54 57 18172 12828 42590278
Acute generalised exanthematous pustulosis 81.64 14.54 49 18180 8546 42594560
Mechanical ventilation complication 81.40 14.54 24 18205 680 42602426
Lymphopenia 71.24 14.54 65 18164 21498 42581608
Anhedonia 71.13 14.54 43 18186 7597 42595509
Injury 69.33 14.54 65 18164 22251 42580855
Cytomegalovirus viraemia 68.40 14.54 47 18182 10330 42592776
Renal injury 67.98 14.54 50 18179 12230 42590876
Rash maculo-papular 66.33 14.54 81 18148 37422 42565684
Vitamin K deficiency 64.66 14.54 18 18211 413 42602693
Death 64.64 14.54 64 18165 471121 42131985
Haemothorax 63.49 14.54 35 18194 5201 42597905
Fungal infection 62.33 14.54 58 18171 19664 42583442
Emotional distress 62.13 14.54 53 18176 16040 42587066
Coagulopathy 62.12 14.54 61 18168 22101 42581005
Erythema 62.10 14.54 141 18088 108652 42494454
Face oedema 61.08 14.54 49 18180 13617 42589489
Shock haemorrhagic 57.67 14.54 51 18178 16191 42586915
Cardiac arrest 56.19 14.54 136 18093 109184 42493922
Adverse reaction 54.86 14.54 29 18200 3964 42599142
Inspiratory capacity decreased 50.80 14.54 25 18204 2942 42600164
Gastritis fungal 50.53 14.54 12 18217 142 42602964
Hypovitaminosis 50.04 14.54 17 18212 769 42602337
Brain herniation 49.74 14.54 29 18200 4794 42598312
Allergy test negative 49.56 14.54 12 18217 155 42602951
Pericarditis fungal 45.49 14.54 12 18217 223 42602883
Hyperthermia malignant 44.33 14.54 22 18207 2636 42600470
Weight decreased 43.95 14.54 17 18212 207931 42395175
Rash morbilliform 42.90 14.54 25 18204 4128 42598978
Dizziness 42.70 14.54 27 18202 249227 42353879
Rash 42.09 14.54 231 17998 276723 42326383
Meningitis fungal 41.93 14.54 11 18218 200 42602906
Tachycardia 41.87 14.54 116 18113 100971 42502135
Blood pressure decreased 41.81 14.54 83 18146 58249 42544857
Post procedural hypotension 41.30 14.54 9 18220 70 42603036
Bacterial infection 41.06 14.54 55 18174 27824 42575282
Cellulitis 41.02 14.54 85 18144 61500 42541606
Shock 40.69 14.54 56 18173 29065 42574041
Diabetes insipidus 40.08 14.54 23 18206 3690 42599416
Toxic epidermal necrolysis 39.74 14.54 53 18176 26697 42576409
Confusion postoperative 39.67 14.54 10 18219 154 42602952
Angiopathy 39.37 14.54 26 18203 5351 42597755
Procedural hypotension 38.75 14.54 15 18214 988 42602118
Mycobacterium fortuitum infection 38.69 14.54 12 18217 405 42602701
Vitamin K decreased 38.66 14.54 8 18221 47 42603059
Unevaluable event 37.85 14.54 59 18170 34229 42568877
Device related infection 37.80 14.54 45 18184 20234 42582872
Emphysema 37.76 14.54 35 18194 11800 42591306
Post procedural complication 35.92 14.54 35 18194 12555 42590551
Hypovolaemia 32.90 14.54 32 18197 11453 42591653
Multiple organ dysfunction syndrome 32.23 14.54 103 18126 96932 42506174
Headache 32.15 14.54 33 18196 239336 42363770
Product dose omission issue 31.97 14.54 13 18216 154352 42448754
Diarrhoea 31.61 14.54 97 18132 460752 42142354
Angioedema 31.10 14.54 61 18168 42416 42560690
Dysbiosis 31.02 14.54 12 18217 789 42602317
Hypersensitivity 30.89 14.54 84 18145 72286 42530820
Postoperative delirium 30.60 14.54 11 18218 589 42602517
Type I hypersensitivity 30.52 14.54 16 18213 2150 42600956
Tubulointerstitial nephritis 30.34 14.54 51 18178 31497 42571609
Mycobacterial peritonitis 29.54 14.54 8 18221 165 42602941
Asthenia 29.15 14.54 47 18182 280746 42322360
Eosinophilia 28.78 14.54 51 18178 32848 42570258
Post procedural haematoma 28.74 14.54 14 18215 1611 42601495
Tryptase increased 28.54 14.54 9 18220 321 42602785
Malaise 27.64 14.54 30 18199 212126 42390980
Vascular purpura 27.57 14.54 15 18214 2171 42600935
Coagulation factor X level decreased 26.39 14.54 5 18224 17 42603089
Jaundice cholestatic 25.98 14.54 20 18209 5233 42597873
Pathogen resistance 25.73 14.54 28 18201 11422 42591684
Myoclonus 25.63 14.54 34 18195 17031 42586075
Haemorrhage 25.55 14.54 70 18159 60493 42542613
Adrenal suppression 25.53 14.54 11 18218 954 42602152
Fungaemia 25.01 14.54 16 18213 3120 42599986
Airway peak pressure increased 24.96 14.54 7 18222 165 42602941
Post embolisation syndrome 24.96 14.54 6 18223 75 42603031
Disease progression 23.97 14.54 16 18213 143640 42459466
Renal failure 23.89 14.54 123 18106 143603 42459503
Type IV hypersensitivity reaction 23.41 14.54 14 18215 2423 42600683
Cutaneous vasculitis 23.27 14.54 21 18208 6839 42596267
Factor V inhibition 22.95 14.54 7 18222 223 42602883
Ventricular tachycardia 22.92 14.54 44 18185 30116 42572990
Catheter site haemorrhage 22.84 14.54 14 18215 2534 42600572
Linear IgA disease 22.63 14.54 13 18216 2090 42601016
Embolic stroke 22.36 14.54 18 18211 5022 42598084
Hypoxia 22.19 14.54 73 18156 69713 42533393
Metabolic acidosis 21.93 14.54 60 18169 51798 42551308
Intraventricular haemorrhage 21.91 14.54 16 18213 3868 42599238
Arterial angioplasty 21.82 14.54 5 18224 50 42603056
Burkholderia test positive 21.48 14.54 10 18219 1040 42602066
Strongyloidiasis 21.34 14.54 15 18214 3416 42599690
Serotonin syndrome 21.25 14.54 39 18190 25806 42577300
Pneumothorax 21.24 14.54 37 18192 23506 42579600
Conjunctival ulcer 20.91 14.54 5 18224 61 42603045
Intentional product use issue 20.77 14.54 3 18226 71830 42531276
Gait disturbance 20.70 14.54 8 18221 97992 42505114
Intrapericardial thrombosis 20.69 14.54 5 18224 64 42603042
Pseudomonal sepsis 20.63 14.54 16 18213 4233 42598873
Cardiac valve vegetation 20.58 14.54 8 18221 533 42602573
Scedosporium infection 20.51 14.54 11 18218 1547 42601559
Drug eruption 20.48 14.54 36 18193 23039 42580067
Hepatic function abnormal 20.17 14.54 58 18171 51509 42551597
Off label use 20.01 14.54 176 18053 638159 41964947
Arthralgia 19.77 14.54 36 18193 205202 42397904
Tryptase decreased 19.26 14.54 4 18225 24 42603082
Procedural haemorrhage 19.03 14.54 13 18216 2828 42600278
Subarachnoid haemorrhage 18.97 14.54 27 18202 14445 42588661
Drug-induced liver injury 18.97 14.54 47 18182 38226 42564880
Toxicity to various agents 18.85 14.54 44 18185 229092 42374014
Renal impairment 18.77 14.54 95 18134 110133 42492973
Eyelid oedema 18.47 14.54 17 18212 5678 42597428
Anaesthetic complication 18.38 14.54 10 18219 1447 42601659
Respiratory distress 18.29 14.54 49 18180 41771 42561335
Spontaneous haematoma 17.97 14.54 8 18221 750 42602356
Post procedural haemorrhage 17.90 14.54 21 18208 9291 42593815
Febrile neutropenia 17.50 14.54 33 18196 185670 42417436
Kidney transplant rejection 17.40 14.54 20 18209 8663 42594443
Allergic transfusion reaction 17.37 14.54 4 18225 41 42603065
Haemodynamic instability 17.31 14.54 24 18205 12533 42590573
Viral uveitis 17.28 14.54 4 18225 42 42603064
Electrocardiogram ST segment depression 17.10 14.54 12 18217 2725 42600381
Candida infection 17.00 14.54 32 18197 21578 42581528
Weight increased 16.73 14.54 13 18216 107970 42495136
Herpes dermatitis 16.71 14.54 5 18224 149 42602957
Systemic mastocytosis 16.59 14.54 5 18224 153 42602953
Staphylococcal bacteraemia 16.46 14.54 22 18207 11099 42592007
Ototoxicity 16.44 14.54 11 18218 2314 42600792
Leukocytosis 16.35 14.54 38 18191 29670 42573436
Disseminated intravascular coagulation 16.23 14.54 34 18195 24760 42578346
Herpes simplex hepatitis 16.20 14.54 5 18224 166 42602940
Abdominal discomfort 16.13 14.54 6 18223 75249 42527857
Drug chemical incompatibility 16.12 14.54 3 18226 9 42603097
Electrocardiogram ST segment elevation 15.99 14.54 16 18213 5923 42597183
Torsade de pointes 15.89 14.54 19 18210 8575 42594531
Arthrofibrosis 15.84 14.54 4 18225 62 42603044
Parenteral nutrition 15.76 14.54 7 18222 653 42602453
Blood creatine phosphokinase MB increased 15.58 14.54 10 18219 1960 42601146
Fall 15.56 14.54 50 18179 234470 42368636
Antiviral drug level above therapeutic 15.55 14.54 4 18225 67 42603039
Rash erythematous 15.47 14.54 39 18190 32052 42571054
Dehydration 15.38 14.54 23 18206 141744 42461362
Acinetobacter infection 15.24 14.54 9 18220 1522 42601584
Peripheral swelling 15.12 14.54 10 18219 90260 42512846
Drug hypersensitivity 15.09 14.54 83 18146 99306 42503800
Appendicitis perforated 14.97 14.54 10 18219 2096 42601010
Pneumonia fungal 14.95 14.54 19 18210 9127 42593979
Generalised bullous fixed drug eruption 14.87 14.54 6 18223 441 42602665
Nodal rhythm 14.79 14.54 9 18220 1608 42601498
Toxic shock syndrome 14.75 14.54 6 18223 450 42602656
Anaesthetic complication pulmonary 14.75 14.54 4 18225 83 42603023
Delayed recovery from anaesthesia 14.68 14.54 8 18221 1161 42601945
Reperfusion injury 14.57 14.54 4 18225 87 42603019

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic shock 1594.95 13.32 605 34831 50941 110502922
Anaphylactic reaction 953.27 13.32 540 34896 113760 110440103
Hypotension 379.50 13.32 634 34802 523215 110030648
Acute generalised exanthematous pustulosis 343.02 13.32 158 35278 21506 110532357
Hypoprothrombinaemia 262.10 13.32 61 35375 898 110552965
Bronchospasm 217.44 13.32 130 35306 30109 110523754
Drug reaction with eosinophilia and systemic symptoms 198.62 13.32 183 35253 81912 110471951
Lymphoid tissue hypoplasia 195.91 13.32 54 35382 1611 110552252
Thymus hypoplasia 190.61 13.32 53 35383 1634 110552229
Kounis syndrome 184.48 13.32 70 35366 5855 110548008
Clostridium test positive 180.43 13.32 82 35354 10811 110543052
Clostridium difficile colitis 178.14 13.32 132 35304 43646 110510217
Cardiac arrest 159.33 13.32 251 35185 196502 110357361
Disseminated aspergillosis 153.79 13.32 49 35387 2431 110551432
Urticaria 140.22 13.32 313 35123 318544 110235319
Erythema 139.43 13.32 296 35140 291151 110262712
Fatigue 139.10 13.32 112 35324 1215846 109338017
Tachycardia 128.41 13.32 247 35189 226398 110327465
Vitamin K deficiency 127.70 13.32 34 35402 887 110552976
Coagulopathy 122.55 13.32 103 35333 40808 110513055
Fear 119.99 13.32 81 35355 23112 110530751
Arthrodesis 106.37 13.32 38 35398 2680 110551183
Blood pressure decreased 106.07 13.32 156 35280 114935 110438928
Renal injury 103.18 13.32 68 35368 18645 110535218
Anhedonia 102.33 13.32 63 35373 15365 110538498
Procedural hypotension 101.74 13.32 36 35400 2469 110551394
Rash maculo-papular 99.76 13.32 121 35315 74101 110479762
Type I hypersensitivity 99.21 13.32 46 35390 6347 110547516
Rash 96.98 13.32 518 34918 820446 109733417
Face oedema 91.55 13.32 80 35356 33389 110520474
Mechanical ventilation complication 90.68 13.32 25 35411 746 110553117
Joint swelling 86.95 13.32 18 35418 442827 110111036
Toxic epidermal necrolysis 83.70 13.32 97 35339 56630 110497233
Unevaluable event 83.60 13.32 99 35337 59128 110494735
Renal failure 82.74 13.32 207 35229 226367 110327496
Eosinophilia 80.39 13.32 96 35340 57840 110496023
Cytomegalovirus viraemia 80.06 13.32 57 35379 17707 110536156
Headache 79.28 13.32 100 35336 882277 109671586
Shock haemorrhagic 78.31 13.32 67 35369 27180 110526683
Emotional distress 76.99 13.32 83 35353 44764 110509099
Linear IgA disease 75.72 13.32 34 35402 4355 110549508
Vascular purpura 74.07 13.32 32 35404 3739 110550124
Angioedema 73.28 13.32 121 35315 98379 110455484
Drug intolerance 72.95 13.32 20 35416 406492 110147371
Weight increased 71.03 13.32 23 35413 419621 110134242
Lymphopenia 68.35 13.32 74 35362 40096 110513767
Multiple organ dysfunction syndrome 67.77 13.32 150 35286 151560 110402303
Device related infection 67.59 13.32 73 35363 39446 110514417
Post procedural complication 67.50 13.32 61 35375 26597 110527266
Maternal exposure during delivery 65.95 13.32 29 35407 3536 110550327
Allergy test negative 65.81 13.32 17 35419 393 110553470
Alopecia 65.34 13.32 18 35418 364735 110189128
Bradycardia 65.27 13.32 150 35286 155367 110398496
Shock 63.44 13.32 82 35354 53506 110500357
Sinusitis 62.65 13.32 10 35426 296678 110257185
Systemic lupus erythematosus 62.62 13.32 5 35431 254333 110299530
Toxic skin eruption 62.01 13.32 59 35377 27456 110526407
Peripheral swelling 61.88 13.32 26 35410 404008 110149855
Inspiratory capacity decreased 60.92 13.32 25 35411 2570 110551293
Drug-induced liver injury 60.87 13.32 125 35311 119942 110433921
Dizziness 60.72 13.32 81 35355 698112 109855751
Haemothorax 60.55 13.32 34 35402 6997 110546866
Premature delivery 60.30 13.32 61 35375 30571 110523292
Arthralgia 59.50 13.32 99 35337 779533 109774330
Malaise 58.35 13.32 78 35358 671741 109882122
Hyperthermia malignant 57.23 13.32 27 35409 3873 110549990
Nasopharyngitis 56.31 13.32 28 35408 394333 110159530
Pericarditis 54.81 13.32 4 35432 219110 110334753
Cellulitis 54.48 13.32 123 35313 125893 110427970
Weight decreased 53.42 13.32 43 35393 468014 110085849
Disseminated intravascular coagulation 53.35 13.32 66 35370 41220 110512643
Brain herniation 53.26 13.32 34 35402 8829 110545034
Anaesthetic complication 53.02 13.32 25 35411 3581 110550282
Infusion related reaction 53.02 13.32 28 35408 381134 110172729
Circulatory collapse 52.79 13.32 67 35369 42926 110510937
Product dose omission issue 52.07 13.32 19 35417 321763 110232100
Asthenia 50.26 13.32 90 35346 688909 109864954
Mobility decreased 50.12 13.32 8 35428 237414 110316449
Lower respiratory tract infection 49.54 13.32 9 35427 243097 110310766
Diabetes insipidus 49.18 13.32 29 35407 6541 110547322
Intentional product use issue 48.78 13.32 10 35426 247896 110305967
Generalised tonic-clonic seizure 48.74 13.32 73 35363 54607 110499256
Mycobacterial peritonitis 48.53 13.32 12 35424 231 110553632
Vitamin K decreased 48.52 13.32 10 35426 80 110553783
Hypovitaminosis 48.17 13.32 18 35418 1442 110552421
Death 47.71 13.32 95 35341 698774 109855089
Hepatic function abnormal 46.48 13.32 94 35342 89201 110464662
Bacterial infection 46.19 13.32 65 35371 45971 110507892
Sleep disorder 45.98 13.32 5 35431 198639 110355224
Fungal infection 45.53 13.32 68 35368 50738 110503125
Pericarditis fungal 45.48 13.32 12 35424 302 110553561
Diarrhoea 45.13 13.32 200 35236 1139305 109414558
Gastritis fungal 44.89 13.32 12 35424 318 110553545
Acute kidney injury 44.62 13.32 352 35084 635078 109918785
Mycobacterium fortuitum infection 44.31 13.32 13 35423 487 110553376
Musculoskeletal pain 43.95 13.32 4 35432 183019 110370844
Tryptase increased 43.88 13.32 15 35421 928 110552935
Gastrointestinal disorder 43.20 13.32 12 35424 241940 110311923
Rash morbilliform 41.67 13.32 28 35408 7923 110545940
Renal impairment 41.63 13.32 144 35292 188301 110365562
Musculoskeletal stiffness 41.25 13.32 19 35417 279803 110274060
Post procedural hypotension 41.17 13.32 9 35427 98 110553765
Wound 41.17 13.32 12 35424 234425 110319438
Airway peak pressure increased 41.05 13.32 13 35423 632 110553231
Post procedural haematoma 40.98 13.32 19 35417 2620 110551243
Encephalopathy 40.62 13.32 84 35352 80971 110472892
Fibromyalgia 40.33 13.32 4 35432 170905 110382958
Arthropathy 40.15 13.32 21 35415 287501 110266362
Asthma 40.11 13.32 15 35421 250276 110303587
Cutaneous vasculitis 40.08 13.32 33 35403 12696 110541167
Meningitis fungal 39.91 13.32 11 35425 328 110553535
Injection site pain 39.88 13.32 5 35431 177917 110375946
Pseudomembranous colitis 39.61 13.32 25 35411 6366 110547497
Contusion 39.09 13.32 13 35423 233348 110320515
Pain in extremity 38.85 13.32 60 35376 487058 110066805
Hypoxia 38.79 13.32 110 35326 129405 110424458
Haemodynamic instability 38.65 13.32 42 35394 22846 110531017
Dysbiosis 38.33 13.32 17 35419 2115 110551748
Migraine 38.05 13.32 5 35431 171647 110382216
Muscle spasms 37.84 13.32 21 35415 278136 110275727
Oxygen saturation decreased 37.36 13.32 123 35313 156859 110397004
Eyelid oedema 36.83 13.32 34 35402 15228 110538635
Tubulointerstitial nephritis 36.80 13.32 64 35372 54220 110499643
Ventricular tachycardia 36.60 13.32 61 35375 49948 110503915
Postoperative delirium 36.59 13.32 13 35423 902 110552961
Insomnia 36.50 13.32 37 35399 360553 110193310
Haemolytic anaemia 36.40 13.32 39 35397 20881 110532982
Staphylococcal bacteraemia 36.12 13.32 35 35401 16653 110537210
Angiopathy 34.77 13.32 26 35410 8704 110545159
Confusion postoperative 34.52 13.32 10 35426 358 110553505
Swelling 34.42 13.32 37 35399 351004 110202859
Pulseless electrical activity 34.13 13.32 34 35402 16723 110537140
Stress cardiomyopathy 33.93 13.32 33 35403 15773 110538090
Treatment failure 33.48 13.32 24 35412 277210 110276653
International normalised ratio increased 33.45 13.32 81 35355 86691 110467172
Hypoaesthesia 33.24 13.32 31 35405 314192 110239671
Recurrence of neuromuscular blockade 32.96 13.32 10 35426 421 110553442
Septic shock 32.74 13.32 118 35318 157410 110396453
Heparin-induced thrombocytopenia 32.64 13.32 28 35408 11396 110542467
Post procedural haemorrhage 32.57 13.32 32 35404 15480 110538383
Folliculitis 32.49 13.32 7 35429 167646 110386217
Hypovolaemia 31.86 13.32 37 35399 21637 110532226
Stomatitis 31.85 13.32 24 35412 270218 110283645
Intentional product misuse 31.65 13.32 3 35433 132901 110420962
General physical health deterioration 31.47 13.32 55 35381 425240 110128623
Cholestasis 31.32 13.32 66 35370 64452 110489411
Pneumothorax 31.29 13.32 47 35389 35238 110518625
Type IV hypersensitivity reaction 31.03 13.32 21 35415 6012 110547851
Anaphylactoid reaction 30.98 13.32 22 35414 6804 110547059
Contraindicated product administered 30.63 13.32 21 35415 248246 110305617
Torsade de pointes 30.60 13.32 37 35399 22563 110531300
Toxicity to various agents 30.51 13.32 68 35368 480487 110073376
Peritonitis bacterial 30.47 13.32 26 35410 10507 110543356
Laryngeal oedema 30.00 13.32 25 35411 9782 110544081
Arthrofibrosis 29.89 13.32 7 35429 106 110553757
Shoulder arthroplasty 29.86 13.32 17 35419 3590 110550273
Abdominal pain upper 29.78 13.32 41 35395 349070 110204793
Myoclonus 29.33 13.32 44 35392 32954 110520909
Hypothermia 29.19 13.32 39 35397 26263 110527600
Metabolic acidosis 29.17 13.32 84 35352 99660 110454203
Pathogen resistance 29.09 13.32 32 35404 17640 110536223
Respiratory failure 28.84 13.32 141 35295 215191 110338672
Drug eruption 28.53 13.32 57 35379 53602 110500261
Myocardial calcification 28.42 13.32 8 35428 258 110553605
Emphysema 27.83 13.32 33 35403 19723 110534140
Loss of personal independence in daily activities 27.61 13.32 7 35429 150013 110403850
Ill-defined disorder 27.58 13.32 8 35428 156845 110397018
Pseudomonal sepsis 27.54 13.32 23 35413 9023 110544840
Hepatitis cholestatic 27.53 13.32 31 35405 17535 110536328
Mixed liver injury 27.40 13.32 26 35410 12053 110541810
Clostridium difficile infection 27.27 13.32 55 35381 52074 110501789
Strongyloidiasis 27.19 13.32 18 35418 4968 110548895
Lung disorder 26.88 13.32 12 35424 180035 110373828
Staphylococcal infection 26.65 13.32 65 35371 69879 110483984
Tarsal tunnel syndrome 26.59 13.32 9 35427 540 110553323
Conjunctival ulcer 26.33 13.32 6 35430 80 110553783
Leukocytosis 26.05 13.32 55 35381 53773 110500090
Joint range of motion decreased 25.94 13.32 4 35432 121828 110432035
Procedural haemorrhage 25.81 13.32 18 35418 5409 110548454
Haemorrhage 25.74 13.32 84 35352 106608 110447255
Pleural effusion 25.71 13.32 119 35317 177590 110376273
Purpura senile 25.59 13.32 9 35427 606 110553257
Limb operation 25.59 13.32 16 35420 4008 110549855
Inappropriate schedule of product administration 25.42 13.32 17 35419 203620 110350243
Post embolisation syndrome 25.19 13.32 6 35430 98 110553765
Respiratory distress 25.18 13.32 63 35373 68811 110485052
Night sweats 25.14 13.32 6 35430 133977 110419886
Impaired healing 25.13 13.32 16 35420 196701 110357162
Cardio-respiratory arrest 25.12 13.32 88 35348 115748 110438115
Blood cholesterol increased 25.05 13.32 14 35422 184771 110369092
Drug hypersensitivity 24.74 13.32 238 35198 453852 110100011
Airway complication of anaesthesia 24.66 13.32 9 35427 675 110553188
Catheter site haemorrhage 24.51 13.32 18 35418 5862 110548001
Fall 24.36 13.32 105 35331 603377 109950486
Hepatic enzyme increased 24.18 13.32 41 35395 320851 110233012
Embolic stroke 24.11 13.32 21 35415 8722 110545141
Hepatic enzyme abnormal 24.05 13.32 22 35414 9741 110544122
Bursitis 24.03 13.32 6 35430 129912 110423951
Off label use 23.95 13.32 338 35098 1499847 109054016
Blood creatinine increased 23.95 13.32 119 35317 182770 110371093
Gait inability 23.90 13.32 7 35429 136369 110417494
Gastrooesophageal reflux disease 23.88 13.32 14 35422 179962 110373901
Cardiogenic shock 23.70 13.32 55 35381 57283 110496580
Therapeutic product effect decreased 23.67 13.32 26 35410 244290 110309573
Obesity 23.51 13.32 4 35432 113347 110440516
Thrombotic microangiopathy 23.29 13.32 37 35399 29112 110524751
Intraventricular haemorrhage 23.28 13.32 17 35419 5490 110548373
Electrocardiogram ST segment elevation 23.26 13.32 21 35415 9139 110544724
Arterial angioplasty 23.26 13.32 5 35431 50 110553813
Renal cortical necrosis 23.08 13.32 8 35428 516 110553347
Prothrombin time prolonged 22.95 13.32 28 35408 17233 110536630
Discomfort 22.91 13.32 21 35415 214686 110339177
Pain 22.86 13.32 196 35240 954759 109599104
Cerebral infarction 22.84 13.32 51 35385 51787 110502076
Procedural complication 22.80 13.32 20 35416 8385 110545478
Delayed recovery from anaesthesia 22.65 13.32 12 35424 2203 110551660
Adrenal suppression 22.63 13.32 11 35425 1685 110552178
Memory impairment 22.56 13.32 18 35418 196926 110356937
Disease progression 22.52 13.32 27 35409 244007 110309856
Bacteraemia 22.50 13.32 45 35391 42345 110511518
Lip oedema 22.47 13.32 19 35417 7581 110546282
Purpura 22.36 13.32 33 35403 24355 110529508
Acinetobacter infection 22.20 13.32 14 35422 3559 110550304
Acute hepatic failure 22.16 13.32 41 35395 36427 110517436
Intrapericardial thrombosis 22.13 13.32 5 35431 64 110553799
Tonic clonic movements 22.02 13.32 13 35423 2939 110550924
Dry mouth 22.00 13.32 19 35417 199929 110353934
Stridor 21.97 13.32 18 35418 6877 110546986
Hepatic cytolysis 21.87 13.32 52 35384 55001 110498862
Oropharyngeal pain 21.85 13.32 8 35428 135268 110418595
Macular oedema 21.81 13.32 18 35418 6948 110546915
Fungaemia 21.76 13.32 17 35419 6069 110547794
Skin test negative 21.71 13.32 5 35431 70 110553793
Injury 21.57 13.32 113 35323 177152 110376711
Psoriasis 21.42 13.32 9 35427 139984 110413879
Manipulation 21.15 13.32 5 35431 79 110553784
Pancytopenia 21.12 13.32 127 35309 209486 110344377
Factor V inhibition 21.11 13.32 7 35429 394 110553469
Tongue oedema 21.11 13.32 19 35417 8237 110545626
Pyrexia 21.00 13.32 404 35032 897861 109656002
Ventricular fibrillation 20.91 13.32 43 35393 41270 110512593
Circumoral oedema 20.54 13.32 7 35429 429 110553434
Skin graft 20.43 13.32 9 35427 1102 110552761
Acute febrile neutrophilic dermatosis 20.33 13.32 15 35421 4921 110548942
Arthritis bacterial 20.30 13.32 21 35415 10799 110543064
Tryptase decreased 20.27 13.32 4 35432 25 110553838
Kidney transplant rejection 20.24 13.32 22 35414 11965 110541898
Necrotising oesophagitis 20.22 13.32 10 35426 1590 110552273
Aspartate aminotransferase increased 20.19 13.32 103 35333 159833 110394030
Pyomyositis 20.18 13.32 8 35428 752 110553111
Coagulation factor X level decreased 20.14 13.32 5 35431 98 110553765
Visual impairment 20 13.32 9 35427 134419 110419444
Dyspepsia 19.99 13.32 19 35417 190946 110362917
Multiple lentigines syndrome 19.84 13.32 6 35430 250 110553613
Sciatica 19.75 13.32 3 35433 92396 110461467
Blood creatine phosphokinase MB increased 19.62 13.32 12 35424 2891 110550972
Anuria 19.59 13.32 31 35405 24310 110529553
Therapeutic product effect incomplete 19.36 13.32 26 35410 223779 110330084
Cataract subcapsular 19.34 13.32 9 35427 1252 110552611
Osteoarthritis 19.32 13.32 18 35418 182605 110371258
Hypercholesterolaemia 19.30 13.32 3 35433 90834 110463029
Endotracheal intubation complication 19.23 13.32 8 35428 851 110553012
Glomerular filtration rate abnormal 19.11 13.32 11 35425 2372 110551491
Brain oedema 18.94 13.32 35 35401 31063 110522800
Cholestatic liver injury 18.91 13.32 17 35419 7359 110546504
Cough 18.82 13.32 80 35356 461561 110092302
C-reactive protein abnormal 18.80 13.32 9 35427 129686 110424177
Scedosporium infection 18.79 13.32 11 35425 2447 110551416
Spinal cord haematoma 18.63 13.32 6 35430 308 110553555
Confusional state 18.63 13.32 82 35354 468598 110085265
Postoperative wound infection 18.47 13.32 24 35412 15729 110538134
Rash erythematous 18.46 13.32 63 35373 81769 110472094
Alanine aminotransferase increased 18.29 13.32 111 35325 183662 110370201
Urticarial vasculitis 18.17 13.32 8 35428 978 110552885
Gait disturbance 17.94 13.32 39 35397 278169 110275694
Cardiac valve vegetation 17.76 13.32 8 35428 1032 110552831
Resorption bone increased 17.66 13.32 9 35427 1525 110552338
Implant site infection 17.65 13.32 10 35426 2093 110551770
Adverse reaction 17.64 13.32 33 35403 29561 110524302
Tachypnoea 17.63 13.32 39 35397 39356 110514507
Hypoventilation 17.58 13.32 17 35419 8064 110545799
Eye abscess 17.57 13.32 6 35430 370 110553493
Subarachnoid haemorrhage 17.56 13.32 33 35403 29669 110524194
Adverse drug reaction 17.46 13.32 6 35430 105553 110448310
Anaesthetic complication pulmonary 17.43 13.32 5 35431 173 110553690
Inflammation 17.18 13.32 22 35414 193216 110360647
Dyspnoea 17.05 13.32 251 35185 1106621 109447242
Fear of death 16.95 13.32 9 35427 1658 110552205
Illness 16.82 13.32 3 35433 82168 110471695
Feeling abnormal 16.66 13.32 20 35416 180691 110373172
Diabetic retinal oedema 16.59 13.32 6 35430 438 110553425
Implant site haematoma 16.59 13.32 5 35431 206 110553657
Sinus tachycardia 16.58 13.32 41 35395 44452 110509411
Pulmonary fibrosis 16.53 13.32 6 35430 102036 110451827
Herpes simplex hepatitis 16.50 13.32 7 35429 782 110553081
Jaundice 16.47 13.32 49 35387 59187 110494676
Hand deformity 16.38 13.32 28 35408 218478 110335385
Altered state of consciousness 16.33 13.32 48 35388 57578 110496285
Stevens-Johnson syndrome 16.20 13.32 42 35394 46859 110507004
Arthritis 16.04 13.32 18 35418 167568 110386295
Product use issue 16.02 13.32 49 35387 311646 110242217
Allergic transfusion reaction 15.95 13.32 5 35431 235 110553628
Hypersensitivity vasculitis 15.86 13.32 15 35421 6922 110546941
Symmetrical drug-related intertriginous and flexural exanthema 15.86 13.32 9 35427 1888 110551975
Amnesia 15.77 13.32 7 35429 105401 110448462
Parenteral nutrition 15.62 13.32 7 35429 893 110552970
Spontaneous haematoma 15.59 13.32 9 35427 1952 110551911
Vestibular disorder 15.57 13.32 10 35426 2622 110551241
Hypokalaemia 15.57 13.32 106 35330 182342 110371521
Delayed graft function 15.46 13.32 12 35424 4245 110549618
Endotracheal intubation 15.43 13.32 14 35422 6130 110547733
End-tidal CO2 decreased 15.42 13.32 4 35432 94 110553769
Transplant rejection 15.41 13.32 28 35408 24539 110529324
Heparin resistance 15.35 13.32 5 35431 266 110553597
Pneumonia 15.21 13.32 194 35242 876520 109677343
Jaundice cholestatic 15.21 13.32 21 35415 14587 110539276
Unresponsive to stimuli 15.18 13.32 50 35386 63740 110490123
Petechiae 15.17 13.32 27 35409 23290 110530573
Antiviral drug level above therapeutic 15.15 13.32 4 35432 101 110553762
Pyroglutamic acidosis 15.14 13.32 9 35427 2059 110551804
Endocarditis 15.10 13.32 20 35416 13351 110540512
Staphylococcus test positive 15.10 13.32 15 35421 7355 110546508
Abdominal discomfort 14.99 13.32 70 35366 393788 110160075
Propionibacterium infection 14.92 13.32 5 35431 291 110553572
Toxic shock syndrome 14.88 13.32 8 35428 1512 110552351
Apnoea 14.79 13.32 20 35416 13619 110540244
Road traffic accident 14.75 13.32 8 35428 107390 110446473
Conjunctival oedema 14.70 13.32 8 35428 1548 110552315
Candida infection 14.58 13.32 41 35395 47968 110505895
Cardiac tamponade 14.48 13.32 18 35418 11289 110542574
COVID-19 14.47 13.32 36 35400 245024 110308839
Jaundice acholuric 14.46 13.32 4 35432 121 110553742
Irregular breathing 14.45 13.32 6 35430 635 110553228
Osteoporosis 14.33 13.32 5 35431 87147 110466716
Muscular weakness 14.29 13.32 37 35399 248431 110305432
Chest pain 14.26 13.32 67 35369 376308 110177555
Vertigo 14.26 13.32 5 35431 86865 110466998
Myocardial stunning 14.16 13.32 5 35431 341 110553522
Wound dehiscence 14.13 13.32 15 35421 7947 110545916
Documented hypersensitivity to administered product 14.07 13.32 7 35429 1127 110552736
Systemic mastocytosis 14.06 13.32 5 35431 348 110553515
Pruritus 14.05 13.32 263 35173 581297 109972566
Laryngeal dyspnoea 14.02 13.32 5 35431 351 110553512
Intensive care 13.98 13.32 9 35427 2370 110551493
Herpes dermatitis 13.96 13.32 5 35431 355 110553508
Decorticate posture 13.91 13.32 5 35431 359 110553504
Atelectasis 13.86 13.32 34 35402 36678 110517185
Status epilepticus 13.84 13.32 31 35405 31540 110522323
Drug chemical incompatibility 13.81 13.32 4 35432 143 110553720
Venous haemorrhage 13.74 13.32 5 35431 372 110553491
Ototoxicity 13.62 13.32 11 35425 4120 110549743
Blood pressure systolic decreased 13.51 13.32 19 35417 13422 110540441
Haemodialysis 13.48 13.32 22 35414 17697 110536166
Electroencephalogram abnormal 13.46 13.32 13 35423 6160 110547703
Episcleritis 13.34 13.32 7 35429 1259 110552604

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01DB04 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
First-generation cephalosporins
FDA CS M0003827 Cephalosporins
FDA EPC N0000175488 Cephalosporin Antibacterial
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35610 antineoplastic agent
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:74518 anti-obesity agent

Related Drugs by ATC class:

J01DB First-generation cephalosporins 11 drugs
cefacetrilecefadroxilcefalexincefaloridinecefalotincefapirincefatrizinecefazedonecefradinecefroxadineceftezole

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bacterial septicemia indication 10001005 DOID:0040085
Infection of skin AND/OR subcutaneous tissue indication 19824006
Staphylococcal pneumonia indication 22754005
Pneumonia due to Streptococcus indication 34020007
Lower respiratory tract infection indication 50417007
Bacterial pneumonia indication 53084003 DOID:874
Cholangitis indication 82403002 DOID:9446
Infection of bone indication 111253001
Bacterial endocarditis indication 301183007
Bacterial urinary infection indication 312124009
Infectious disorder of joint indication 363162000
Infection of biliary tract indication 846685008
Prevention of Perioperative Infection indication
Genitourinary Tract Infections indication
Prevention of Bacterial Endocarditis off-label use
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Factor II deficiency contraindication 73975000
Pseudomembranous enterocolitis contraindication 397683000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.22 acidic
pKa2 12.21 acidic
pKa3 1.52 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Bacterial penicillin-binding protein Enzyme INHIBITOR CHEMBL CHEMBL
Penicillin-binding protein 1A Enzyme WOMBAT-PK

External reference:

IDSource
4019659 VUID
N0000147751 NUI
D00905 KEGG_DRUG
27164-46-1 SECONDARY_CAS_RN
203171 RXNORM
C0007546 UMLSCUI
CHEBI:474053 CHEBI
X56 PDB_CHEM_ID
CHEMBL1435 ChEMBL_ID
CHEMBL1200523 ChEMBL_ID
D002437 MESH_DESCRIPTOR_UI
DB01327 DRUGBANK_ID
10935 IUPHAR_LIGAND_ID
2991 INN_ID
IHS69L0Y4T UNII
33255 PUBCHEM_CID
35509 MMSL
4371 MMSL
948 MMSL
d00007 MMSL
387470007 SNOMEDCT_US
80972005 SNOMEDCT_US
81088002 SNOMEDCT_US
4017460 VANDF
4019659 VANDF
002720 NDDF
004841 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9139 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS NDA 29 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9140 INJECTION, POWDER, FOR SOLUTION 3 g INTRAVENOUS NDA 29 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9261 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 23 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9262 INJECTION, POWDER, FOR SOLUTION 330 mg INTRAMUSCULAR ANDA 24 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9665 INJECTION, POWDER, FOR SOLUTION 20 g INTRAVENOUS ANDA 23 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9923 INJECTION, POWDER, FOR SOLUTION 225 mg INTRAMUSCULAR ANDA 24 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9924 INJECTION, POWDER, FOR SOLUTION 330 mg INTRAMUSCULAR ANDA 24 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9983 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 23 sections
Cefazolin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0264-3103 SOLUTION 1 g INTRAVENOUS NDA 27 sections
Cefazolin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0264-3105 SOLUTION 2 g INTRAVENOUS NDA 27 sections
Cefazolin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0264-3107 SOLUTION 3 g INTRAVENOUS NDA 27 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 0338-0096 INJECTION, SOLUTION 3 g INTRAVENOUS NDA 27 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 0338-3503 INJECTION, SOLUTION 1 g INTRAVENOUS NDA 27 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 0338-3508 INJECTION, SOLUTION 2 g INTRAVENOUS NDA 27 sections
CEFAZOLIN HUMAN PRESCRIPTION DRUG LABEL 1 0404-9833 INJECTION, POWDER, FOR SOLUTION 1 g INTRAMUSCULAR ANDA 11 sections
CEFAZOLIN HUMAN PRESCRIPTION DRUG LABEL 1 0404-9833 INJECTION, POWDER, FOR SOLUTION 1 g INTRAMUSCULAR ANDA 11 sections
CEFAZOLIN HUMAN PRESCRIPTION DRUG LABEL 1 0404-9834 INJECTION, POWDER, FOR SOLUTION 330 mg INTRAMUSCULAR ANDA 10 sections
CEFAZOLIN HUMAN PRESCRIPTION DRUG LABEL 1 0404-9834 INJECTION, POWDER, FOR SOLUTION 330 mg INTRAMUSCULAR ANDA 10 sections
CEFAZOLIN HUMAN PRESCRIPTION DRUG LABEL 1 0404-9835 INJECTION, POWDER, FOR SOLUTION 225 mg INTRAMUSCULAR ANDA 11 sections
CEFAZOLIN HUMAN PRESCRIPTION DRUG LABEL 1 0404-9835 INJECTION, POWDER, FOR SOLUTION 225 mg INTRAMUSCULAR ANDA 11 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 0409-2585 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 23 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 0781-3450 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAMUSCULAR ANDA 21 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 0781-3451 INJECTION, POWDER, FOR SOLUTION 1 g INTRAMUSCULAR ANDA 21 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 0781-3452 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 21 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 44567-120 INJECTION, POWDER, FOR SOLUTION 1 g INTRAMUSCULAR ANDA 21 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 44567-706 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAMUSCULAR ANDA 21 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 44567-707 INJECTION, POWDER, FOR SOLUTION 1 g INTRAMUSCULAR ANDA 21 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 44567-708 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 21 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 44567-840 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS NDA 25 sections
Cefazolin HUMAN PRESCRIPTION DRUG LABEL 1 44567-845 INJECTION, POWDER, FOR SOLUTION 3 g INTRAVENOUS NDA 25 sections