cefalexin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 571 15686-71-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cefalexin hydrochloride
  • cephalexin
  • cefalexin
  • cephacillin
  • cephalexin anhydrous
  • cephalexin hydrochloride
  • cephalexin hydrate
  • cefalexin HCl
  • cephalexin HCl
A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.
  • Molecular weight: 347.39
  • Formula: C16H17N3O4S
  • CLOGP: -1.84
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 112.73
  • ALOGS: -3.07
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 13.50 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 91 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 192.00 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.21 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.90 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.85 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.57 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -1.554 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.484 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.516 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 1.535 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 78.090 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 59.160 % High 1
herg hERG pIC50 4.500 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 1.422 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.540 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 65.890 % High 1
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,ERBB2,GRK2,GRK3,GSK3B,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PIK3CB,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TTK 38
kinase-selectivity-class ACVR2B,AXL,BRAF,CDK9,DYRK1B,EIF2AK3,EPHB4,GRK2,MAP2K6,MAPK7,PRKDC,STK33,TEK,TGFBR1,TTK 15
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.733 High 0.82
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.681 High 1
mh-clint Mouse hepatocyte intrinsic clearance 1.875 High 1
mppb Mouse plasma protein binding (% unbound) 79.170 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.146 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 65.740 % High 1
rat-kpuu-brain Rat brain Kpuu 0.008 % High 0.82
rh-clint Rat hepatocyte intrinsic clearance 1.219 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 87.170 % High 1
rppb Rat plasma protein binding (% unbound) 62.830 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 950.605 uM High 1

Approvals:

DateAgencyCompanyOrphan
Jan. 4, 1971 FDA SHIONOGI INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 961.89 11.03 1235 49431 462374 90115407
Swollen tongue 261.44 11.03 212 50454 45744 90532037
Swelling face 206.73 11.03 241 50425 81111 90496670
Type IV hypersensitivity reaction 206.34 11.03 79 50587 3847 90573934
Cross sensitivity reaction 203.85 11.03 72 50594 2785 90574996
Cellulitis 198.56 11.03 250 50416 91087 90486694
Loss of employment 193.22 11.03 70 50596 2917 90574864
Dysphonia 189.60 11.03 204 50462 62880 90514901
Angioedema 176.30 11.03 199 50467 64677 90513104
Pemphigus 160.05 11.03 5 50661 326859 90250922
Systemic lupus erythematosus 148.64 11.03 15 50651 361881 90215900
Hand deformity 147.05 11.03 4 50662 296358 90281423
Urinary tract infection 146.83 11.03 439 50227 305193 90272588
Synovitis 139.86 11.03 12 50654 329740 90248041
Urinary tract discomfort 135.03 11.03 40 50626 872 90576909
Glossodynia 133.01 11.03 13 50653 321766 90256015
Pericarditis 132.72 11.03 4 50662 270147 90307634
Drug ineffective for unapproved indication 130.07 11.03 173 50493 66471 90511310
Alveolar osteitis 124.97 11.03 40 50626 1137 90576644
Wound complication 123.40 11.03 58 50608 4705 90573076
Infusion related reaction 116.01 11.03 44 50622 416736 90161045
Animal scratch 115.06 11.03 42 50624 1788 90575993
Tunnel vision 110.53 11.03 40 50626 1661 90576120
Bladder pain 108.71 11.03 45 50621 2692 90575089
Duodenal ulcer perforation 102.81 11.03 5 50661 221283 90356498
Arthropathy 98.08 11.03 41 50625 366201 90211580
Hepatic steatosis 93.05 11.03 109 50557 36836 90540945
Ear congestion 92.53 11.03 43 50623 3399 90574382
Oesophageal spasm 87.29 11.03 41 50625 3320 90574461
General physical health deterioration 86.97 11.03 45 50621 355070 90222711
Clostridium test positive 85.06 11.03 47 50619 5354 90572427
Joint swelling 84.66 11.03 94 50572 503206 90074575
Muscle injury 82.02 11.03 4 50662 176650 90401131
Wound secretion 80.17 11.03 44 50622 4946 90572835
Bronchopulmonary aspergillosis allergic 79.90 11.03 40 50626 3726 90574055
Sinus pain 77.01 11.03 44 50622 5345 90572436
Paranasal sinus discomfort 76.35 11.03 46 50620 6164 90571617
Polymyalgia rheumatica 74.80 11.03 42 50624 4935 90572846
Limb injury 74.46 11.03 90 50576 31418 90546363
Rash 74.12 11.03 724 49942 795376 89782405
Folliculitis 73.09 11.03 13 50653 204340 90373441
Type 2 diabetes mellitus 72.54 11.03 13 50653 203231 90374550
Oesophageal pain 71.47 11.03 39 50627 4335 90573446
Skin laceration 70.93 11.03 80 50586 25955 90551826
Alopecia 69.33 11.03 106 50560 494965 90082816
Irritable bowel syndrome 68.38 11.03 16 50650 207432 90370349
Acute generalised exanthematous pustulosis 63.08 11.03 56 50610 13647 90564134
Rash maculo-papular 61.74 11.03 94 50572 40839 90536942
Lymphoedema 60.93 11.03 55 50611 13698 90564083
Dysuria 55.96 11.03 88 50578 39313 90538468
Calculus urinary 54.48 11.03 24 50642 1674 90576107
Psoriatic arthropathy 54.30 11.03 30 50636 228305 90349476
Anaphylactic reaction 54.10 11.03 138 50528 87386 90490395
Emotional distress 53.62 11.03 83 50583 36579 90541202
C-reactive protein abnormal 53 11.03 5 50661 127424 90450357
Mobility decreased 52.68 11.03 38 50628 250696 90327085
Cardiac failure congestive 52.31 11.03 147 50519 98547 90479234
Pollakiuria 51.49 11.03 77 50589 32928 90544853
Hepatic enzyme increased 50.69 11.03 77 50589 360659 90217122
Rheumatoid arthritis 50.38 11.03 78 50588 362536 90215245
Discomfort 49.72 11.03 48 50618 274287 90303494
Treatment failure 49.70 11.03 58 50608 303870 90273911
Wound 49.35 11.03 58 50608 302922 90274859
Hypokinesia 49.32 11.03 52 50614 15645 90562136
Liver injury 49.10 11.03 17 50649 170550 90407231
Blood urine present 48.62 11.03 54 50612 17224 90560557
Cystitis 46.32 11.03 110 50556 66608 90511173
Diarrhoea 46.29 11.03 759 49907 938431 89639350
Hypoaesthesia oral 46.05 11.03 50 50616 15550 90562231
Impaired healing 46.01 11.03 38 50628 234161 90343620
Nasal polyps 45.25 11.03 42 50624 10838 90566943
Bronchitis 44.95 11.03 187 50479 152740 90425041
Nephrolithiasis 43.20 11.03 89 50577 48996 90528785
Sleep disorder 42.93 11.03 29 50637 198001 90379780
Localised infection 42.28 11.03 71 50595 33491 90544290
Bronchiectasis 42.07 11.03 57 50609 22273 90555508
Joint range of motion decreased 41.75 11.03 12 50654 135631 90442150
Blood iron decreased 40.33 11.03 50 50616 17909 90559872
Bursitis 39.87 11.03 12 50654 131642 90446139
Swelling 39.77 11.03 112 50554 418946 90158835
Cholecystitis chronic 39.08 11.03 37 50629 9789 90567992
Hepatitis infectious mononucleosis 38.72 11.03 10 50656 128 90577653
Hallucination 38.70 11.03 102 50564 65857 90511924
Intentional product use issue 38.08 11.03 39 50627 216853 90360928
Cough 37.89 11.03 343 50323 368619 90209162
Feeling cold 37.15 11.03 60 50606 27405 90550376
Rales 37.05 11.03 45 50621 15782 90561999
Blood cholesterol increased 36.98 11.03 37 50629 207975 90369806
Opsoclonus myoclonus 36.48 11.03 10 50656 163 90577618
Prescribed overdose 35.35 11.03 6 50660 97619 90480162
Product dose omission issue 35.12 11.03 281 50385 291406 90286375
Panic attack 34.85 11.03 57 50609 26308 90551473
Haematuria 33.92 11.03 66 50600 34871 90542910
Ill-defined disorder 33.89 11.03 32 50634 184859 90392922
Hypoacusis 33.87 11.03 58 50608 27792 90549989
Lung disorder 33.77 11.03 21 50645 149862 90427919
Clostridium difficile infection 33.41 11.03 67 50599 36178 90541603
Myopathy 32.57 11.03 39 50627 13479 90564302
C-reactive protein increased 32.55 11.03 32 50634 181357 90396424
Burning sensation 32.14 11.03 93 50573 63359 90514422
Toxicity to various agents 31.91 11.03 71 50595 287775 90290006
Movement disorder 30.87 11.03 57 50609 28962 90548819
Myalgia 30.71 11.03 185 50481 174940 90402841
Therapeutic product effect incomplete 30.61 11.03 38 50628 193858 90383923
Musculoskeletal stiffness 30.58 11.03 76 50590 296456 90281325
Chills 30.27 11.03 150 50516 131831 90445950
Procedural pain 29.95 11.03 61 50605 33299 90544482
Type I hypersensitivity 29.79 11.03 22 50644 4133 90573648
Sleep apnoea syndrome 29.64 11.03 59 50607 31688 90546093
Bronchomalacia 29.40 11.03 9 50657 220 90577561
Lip swelling 29.37 11.03 66 50600 38544 90539237
Headache 29.32 11.03 659 50007 862087 89715694
Chloropsia 29.25 11.03 7 50659 64 90577717
Uterine perforation 29.20 11.03 28 50638 7526 90570255
Night sweats 29.07 11.03 18 50648 128748 90449033
Delirium 29.01 11.03 11 50655 104348 90473433
Influenza 28.96 11.03 154 50512 139110 90438671
Illness 28.75 11.03 106 50560 81863 90495918
Gastric disorder 28.75 11.03 60 50606 33324 90544457
Maternal exposure during pregnancy 28.71 11.03 104 50562 359959 90217822
Joint injury 28.47 11.03 59 50607 32605 90545176
Appetite disorder 28.24 11.03 30 50636 9103 90568678
Drug dependence 27.98 11.03 55 50611 29272 90548509
Chronic kidney disease 27.81 11.03 76 50590 50115 90527666
Nasopharyngitis 27.79 11.03 125 50541 406979 90170802
Ear pain 27.72 11.03 83 50583 57619 90520162
Gastroenteritis bacterial 27.68 11.03 10 50656 413 90577368
Cardiac failure 27.68 11.03 128 50538 109368 90468413
Pulmonary fibrosis 27.22 11.03 13 50653 107490 90470291
Contraindicated product administered 27.18 11.03 90 50576 320049 90257732
Inflammation 27.16 11.03 36 50630 178556 90399225
Pigment nephropathy 27.14 11.03 6 50660 37 90577744
Deep vein thrombosis 26.88 11.03 112 50554 91508 90486273
Pyelonephritis 26.72 11.03 45 50621 21271 90556510
Drug ineffective 26.70 11.03 581 50085 1383717 89194064
Sciatica 26.07 11.03 12 50654 101370 90476411
Arthritis infective 26.04 11.03 27 50639 7965 90569816
Idiosyncratic drug reaction 25.69 11.03 12 50654 959 90576822
Staphylococcal infection 25.51 11.03 72 50594 48367 90529414
Lymphadenitis 25.46 11.03 20 50646 4117 90573664
Condition aggravated 25.39 11.03 212 50454 595333 89982448
Hepatic cirrhosis 24.97 11.03 3 50663 63250 90514531
Tinnitus 24.62 11.03 66 50600 43036 90534745
Skin infection 24.12 11.03 39 50627 17825 90559956
Epilepsy 23.99 11.03 8 50658 82198 90495583
Musculoskeletal pain 23.60 11.03 37 50629 171214 90406567
Skin warm 23.32 11.03 25 50641 7662 90570119
Hypersensitivity 23.23 11.03 370 50296 454307 90123474
Autoimmune disorder 23.23 11.03 7 50659 76737 90501044
Clostridium difficile colitis 23.00 11.03 48 50618 26658 90551123
Hypercholesterolaemia 22.91 11.03 14 50652 100878 90476903
Obstructive airways disorder 22.87 11.03 47 50619 25822 90551959
Gait inability 22.81 11.03 29 50637 146427 90431354
Intentional overdose 22.77 11.03 12 50654 93822 90483959
Gallbladder disorder 22.46 11.03 40 50626 19763 90558018
Wrist fracture 22.32 11.03 35 50631 15589 90562192
Dysphoria 22.26 11.03 22 50644 6132 90571649
Back pain 22.22 11.03 273 50393 316902 90260879
Incorrect dose administered 22 11.03 95 50571 78835 90498946
Sinus disorder 21.99 11.03 55 50611 34392 90543389
Drug reaction with eosinophilia and systemic symptoms 21.97 11.03 63 50603 42695 90535086
Lower limb fracture 21.95 11.03 10 50656 85003 90492778
Toxic epidermal necrolysis 21.89 11.03 53 50613 32475 90545306
Agitation neonatal 21.60 11.03 9 50657 547 90577234
Multiple lentigines syndrome 21.57 11.03 7 50659 208 90577573
Pharyngeal swelling 21.23 11.03 27 50639 9917 90567864
Live birth 20.91 11.03 9 50657 79098 90498683
High frequency ablation 20.85 11.03 7 50659 232 90577549
Asthma 20.60 11.03 68 50598 242092 90335689
Tenderness 20.51 11.03 46 50620 26822 90550959
Haemorrhagic diathesis 20.45 11.03 20 50646 5504 90572277
Fall 20.25 11.03 380 50286 481430 90096351
Myelosuppression 20.06 11.03 3 50663 53588 90524193
Peripheral venous disease 19.97 11.03 11 50655 83910 90493871
Bone erosion 19.78 11.03 3 50663 53018 90524763
Taste disorder 19.77 11.03 5 50661 61541 90516240
Red blood cell sedimentation rate increased 19.41 11.03 11 50655 82584 90495197
Loss of personal independence in daily activities 19.14 11.03 29 50637 136076 90441705
Subcutaneous abscess 19.04 11.03 21 50645 6645 90571136
Lower respiratory tract infection 18.93 11.03 74 50592 250585 90327196
Fibromyalgia 18.90 11.03 56 50610 206213 90371568
Amniotic cavity infection 18.89 11.03 11 50655 1385 90576396
Familial periodic paralysis 18.73 11.03 6 50660 171 90577610
Oral pain 18.62 11.03 50 50616 32633 90545148
Oropharyngeal pain 18.50 11.03 119 50547 115068 90462713
Completed suicide 18.45 11.03 33 50633 145025 90432756
Anhedonia 18.30 11.03 27 50639 11404 90566377
Implant site haematoma 18.27 11.03 5 50661 81 90577700
Pseudomonas infection 18.13 11.03 31 50635 14834 90562947
Underdose 18.12 11.03 4 50662 54013 90523768
Malaise 17.82 11.03 441 50225 585545 89992236
Vision blurred 17.75 11.03 114 50552 110179 90467602
Adverse event 17.51 11.03 24 50642 117394 90460387
Blister infected 17.34 11.03 9 50657 904 90576877
Balance disorder 17.29 11.03 103 50563 96977 90480804
Complement factor C4 increased 17.11 11.03 6 50660 227 90577554
Breast abscess 17.07 11.03 12 50654 2088 90575693
Depression 17.02 11.03 249 50417 300352 90277429
Diabetic retinal oedema 16.97 11.03 7 50659 415 90577366
Pyelonephritis chronic 16.96 11.03 6 50660 233 90577548
Skin ulcer 16.93 11.03 64 50602 50011 90527770
Febrile neutropenia 16.77 11.03 40 50626 158309 90419472
Drug abuse 16.61 11.03 13 50653 82334 90495447
Coma 16.60 11.03 10 50656 72622 90505159
Overdose 16.58 11.03 40 50626 157669 90420112
Surgery 16.55 11.03 59 50607 44828 90532953
Incorrect route of product administration 16.48 11.03 4 50662 50622 90527159
Thinking abnormal 16.37 11.03 26 50640 11706 90566075
Weight increased 16.36 11.03 152 50514 417775 90160006
Obesity 16.31 11.03 21 50645 105486 90472295
Osteomyelitis 16.26 11.03 43 50623 27803 90549978
Pruritus 16.00 11.03 406 50260 541119 90036662
Skin disorder 15.96 11.03 51 50615 36655 90541126
Photophobia 15.78 11.03 36 50630 21233 90556548
Anxiety 15.77 11.03 252 50414 309520 90268261
Dysarthria 15.51 11.03 66 50600 54416 90523365
Hip arthroplasty 15.41 11.03 12 50654 76196 90501585
Poor feeding infant 15.21 11.03 7 50659 541 90577240
Developmental hip dysplasia 15.12 11.03 10 50656 1575 90576206
Implant site infection 15.12 11.03 9 50657 1180 90576601
Wheezing 15.11 11.03 75 50591 238005 90339776
Skin cancer 14.94 11.03 27 50639 13492 90564289
Therapy non-responder 14.90 11.03 34 50632 136670 90441111
Immunoglobulins decreased 14.89 11.03 10 50656 1616 90576165
Throat tightness 14.72 11.03 43 50623 29441 90548340
Ureteric obstruction 14.70 11.03 11 50655 2107 90575674
Nocturia 14.69 11.03 23 50643 10232 90567549
Hyperactive pharyngeal reflex 14.65 11.03 3 50663 12 90577769
Abdominal pain upper 14.52 11.03 264 50402 332410 90245371
Stomatitis 14.47 11.03 92 50574 274606 90303175
Purpura senile 14.44 11.03 7 50659 608 90577173
Erythema 14.22 11.03 193 50473 229053 90348728
Tinea infection 14.15 11.03 9 50657 1327 90576454
Abscess limb 14.03 11.03 17 50649 5945 90571836
Feeling abnormal 13.97 11.03 149 50517 167086 90410695
Abscess drainage 13.91 11.03 7 50659 659 90577122
Umbilical cord around neck 13.81 11.03 5 50661 208 90577573
Prescribed underdose 13.72 11.03 13 50653 75006 90502775
Foetal heart rate decreased 13.69 11.03 5 50661 213 90577568
Nail disorder 13.69 11.03 8 50658 59059 90518722
Thrombocytopenia 13.68 11.03 65 50601 208660 90369121
Scar 13.64 11.03 28 50638 15367 90562414
Abdominal pain 13.60 11.03 303 50363 395418 90182363
Toxic shock syndrome 13.53 11.03 8 50658 1036 90576745
Renal tubular necrosis 13.53 11.03 27 50639 14528 90563253
Dry mouth 13.47 11.03 55 50611 184004 90393777
Knee arthroplasty 13.44 11.03 16 50650 83166 90494615
Cyst 13.37 11.03 29 50637 16532 90561249
Endocrine ophthalmopathy 13.32 11.03 8 50658 1066 90576715
Cataract subcapsular 13.29 11.03 7 50659 724 90577057
Bullous haemorrhagic dermatosis 13.18 11.03 5 50661 237 90577544
Morbid thoughts 13.09 11.03 7 50659 747 90577034
Diabetic foot infection 13.01 11.03 5 50661 246 90577535
Hidradenitis 12.95 11.03 14 50652 4333 90573448
Confusional state 12.84 11.03 146 50520 386059 90191722
Back injury 12.81 11.03 5 50661 46617 90531164
Tinea pedis 12.69 11.03 9 50657 1588 90576193
Body temperature increased 12.60 11.03 54 50612 44656 90533125
Helicobacter duodenal ulcer 12.58 11.03 3 50663 27 90577754
Episcleritis 12.56 11.03 8 50658 1182 90576599
Nasal herpes 12.49 11.03 7 50659 819 90576962
Syncope 12.42 11.03 121 50545 132542 90445239
Economic problem 12.38 11.03 12 50654 3269 90574512
Urticaria 12.21 11.03 244 50422 312490 90265291
Muscle haemorrhage 12.18 11.03 12 50654 3334 90574447
Intestinal obstruction 12.17 11.03 47 50619 37084 90540697
Retroperitoneal haematoma 12.11 11.03 12 50654 3356 90574425
Wound infection 11.98 11.03 26 50640 106376 90471405
Medication error 11.93 11.03 18 50648 84634 90493147
Coeliac disease 11.91 11.03 5 50661 44605 90533176
Tarsal tunnel syndrome 11.86 11.03 6 50660 571 90577210
Rhabdomyolysis 11.79 11.03 7 50659 51249 90526532
Full blood count decreased 11.79 11.03 40 50626 29649 90548132
Therapeutic response decreased 11.78 11.03 20 50646 89709 90488072
Meconium in amniotic fluid 11.77 11.03 5 50661 319 90577462
Myocardial infarction 11.61 11.03 100 50566 105872 90471909
Vanishing bile duct syndrome 11.53 11.03 8 50658 1364 90576417
Liposuction 11.44 11.03 3 50663 41 90577740
Mastitis 11.39 11.03 11 50655 2982 90574799
Malignant neoplasm progression 11.31 11.03 27 50639 106843 90470938
Mycobacterium ulcerans infection 11.24 11.03 3 50663 44 90577737
Therapy cessation 11.09 11.03 45 50621 36316 90541465
Liver function test increased 11.06 11.03 19 50647 84836 90492945
Pregnancy 11.06 11.03 11 50655 62036 90515745

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuritis 281.13 12.99 111 22852 6109 42592263
Pulmonary vasculitis 276.84 12.99 110 22853 6156 42592216
Neurological symptom 233.58 12.99 112 22851 9879 42588493
Eosinophilic granulomatosis with polyangiitis 223.97 12.99 104 22859 8534 42589838
Respiratory symptom 210.67 12.99 108 22855 10998 42587374
Total lung capacity abnormal 210.31 12.99 82 22881 4361 42594011
Pulmonary alveolar haemorrhage 189.40 12.99 111 22852 14705 42583667
Mite allergy 183.30 12.99 77 22886 4969 42593403
Mycotic allergy 182.25 12.99 76 22887 4815 42593557
Dust allergy 179.21 12.99 77 22886 5255 42593117
Spirometry abnormal 175.22 12.99 75 22888 5071 42593301
Conjunctivitis allergic 174.78 12.99 78 22885 5833 42592539
Sleep disorder due to a general medical condition 167.70 12.99 109 22854 17344 42581028
Forced expiratory volume decreased 167.68 12.99 82 22881 7548 42590824
Vasculitis 167.31 12.99 111 22852 18283 42580089
Antineutrophil cytoplasmic antibody positive 156.52 12.99 66 22897 4299 42594073
Normochromic normocytic anaemia 148.98 12.99 80 22883 8951 42589421
Obstructive airways disorder 148.46 12.99 116 22847 24643 42573729
Pulmonary fibrosis 147.14 12.99 119 22844 26562 42571810
Nodule 137.16 12.99 85 22878 12449 42585923
Full blood count abnormal 129.42 12.99 116 22847 29760 42568612
Hypothyroidism 118.53 12.99 114 22849 31970 42566402
Drug hypersensitivity 114.93 12.99 198 22765 99191 42499181
Arteriosclerosis 113.75 12.99 87 22876 17902 42580470
Wheezing 109.29 12.99 141 22822 54640 42543732
Haemoptysis 100.29 12.99 124 22839 46043 42552329
Arteriosclerosis coronary artery 100.20 12.99 82 22881 18595 42579777
Cellulitis 94.99 12.99 140 22823 61445 42536927
Loss of personal independence in daily activities 94.36 12.99 125 22838 49691 42548681
Clostridium test positive 91.44 12.99 49 22914 5456 42592916
Lung disorder 88.84 12.99 119 22844 47804 42550568
Capillaritis 84.27 12.99 35 22928 2193 42596179
Asthma 79.77 12.99 130 22833 62184 42536188
Rash 61.36 12.99 303 22660 276651 42321721
Anxiety 60.53 12.99 170 22793 118390 42479982
Pain in extremity 58.29 12.99 196 22767 150408 42447964
Therapeutic product effect incomplete 56.82 12.99 121 22842 70818 42527554
Productive cough 50.92 12.99 96 22867 51471 42546901
Hypoxia 46.88 12.99 111 22852 69675 42528697
Congenital multiplex arthrogryposis 45.41 12.99 13 22950 260 42598112
Off label use 41.10 12.99 191 22772 638144 41960228
Cerebral palsy 40.55 12.99 13 22950 386 42597986
Drug abuse 39.39 12.99 5 22958 104766 42493606
Thrombosis 38.68 12.99 102 22861 68409 42529963
Clostridium difficile infection 38.54 12.99 54 22909 22605 42575767
Toxicity to various agents 37.41 12.99 41 22922 229095 42369277
General physical health deterioration 33.48 12.99 20 22943 151226 42447146
Conductive deafness 33.44 12.99 12 22951 505 42597867
Venolymphatic malformation 28.77 12.99 6 22957 28 42598344
Skin infection 26.74 12.99 29 22934 9351 42589021
Localised infection 26.71 12.99 43 22920 20330 42578042
Urticaria 26.53 12.99 94 22869 73942 42524430
Drug tolerance decreased 25.80 12.99 16 22947 2344 42596028
Pruritus 25.18 12.99 181 22782 188590 42409782
Autoimmune hepatitis 24.58 12.99 22 22941 5623 42592749
Immunosuppressant drug level decreased 24.18 12.99 14 22949 1810 42596562
Priapism 24.08 12.99 23 22940 6384 42591988
Diplegia 23.13 12.99 12 22951 1250 42597122
Limb injury 22.72 12.99 33 22930 14272 42584100
Urinary tract infection 22.15 12.99 109 22854 99175 42499197
Treatment failure 22.00 12.99 79 22884 62545 42535827
Circumoral oedema 21.93 12.99 6 22957 101 42598271
Renal hypoplasia 21.71 12.99 6 22957 105 42598267
Skin laceration 21.70 12.99 32 22931 14026 42584346
Febrile neutropenia 21.67 12.99 42 22921 185661 42412711
Otitis media 21.50 12.99 17 22946 3666 42594706
Gut fermentation syndrome 21.40 12.99 4 22959 9 42598363
Rash pruritic 20.99 12.99 52 22911 33551 42564821
Anaemia 20.94 12.99 79 22884 280199 42318173
Drug interaction 20.77 12.99 74 22889 266925 42331447
Biliary sepsis 20.50 12.99 10 22953 914 42597458
Type IV hypersensitivity reaction 20.45 12.99 14 22949 2423 42595949
Clostridium difficile colitis 20.26 12.99 39 22924 21213 42577159
Cross sensitivity reaction 19.96 12.99 12 22951 1663 42596709
Drug-induced liver injury 19.60 12.99 55 22908 38218 42560154
Joint contracture 19.43 12.99 13 22950 2168 42596204
Skin lesion 19.08 12.99 44 22919 27130 42571242
Middle ear effusion 18.93 12.99 9 22954 777 42597595
Peripheral swelling 18.65 12.99 97 22866 90173 42508199
Stevens-Johnson syndrome 17.93 12.99 38 22925 22140 42576232
Erythema 17.92 12.99 110 22853 108683 42489689
Skin exfoliation 17.76 12.99 56 22907 41497 42556875
Skin necrosis 17.09 12.99 19 22944 6295 42592077
Liver function test increased 17.02 12.99 35 22928 19963 42578409
Joint dislocation 16.97 12.99 16 22947 4371 42594001
Herpes simplex 16.93 12.99 20 22943 7075 42591297
Talipes 16.79 12.99 12 22951 2224 42596148
Rheumatoid factor negative 16.76 12.99 9 22954 1005 42597367
Hyponatraemia 16.70 12.99 18 22945 101444 42496928
Kounis syndrome 16.42 12.99 14 22949 3354 42595018
Haemorrhoids thrombosed 16.34 12.99 6 22957 270 42598102
Pulmonary embolism 16.10 12.99 115 22848 119497 42478875
Primary biliary cholangitis 15.36 12.99 6 22957 320 42598052
Hypersensitivity vasculitis 14.84 12.99 13 22950 3231 42595141
Paradoxical pain 14.76 12.99 3 22960 12 42598360
Lip haemorrhage 14.75 12.99 8 22955 912 42597460
Electrocardiogram QT prolonged 14.38 12.99 4 22959 47941 42550431
Skin ulcer 14.32 12.99 38 22925 25563 42572809
Multiple organ dysfunction syndrome 14.07 12.99 19 22944 97016 42501356
Joint swelling 13.98 12.99 73 22890 67949 42530423
Perineal abscess 13.89 12.99 6 22957 414 42597958
Rhabdomyolysis 13.80 12.99 13 22950 78006 42520366
Retinal degeneration 13.70 12.99 7 22956 706 42597666
Factor V inhibition 13.61 12.99 5 22958 225 42598147
Renal injury 13.55 12.99 24 22939 12256 42586116
Alveolar osteitis 13.49 12.99 4 22959 91 42598281
Pancytopenia 13.40 12.99 27 22936 117716 42480656
Fracture displacement 13.37 12.99 5 22958 237 42598135
Neovascular age-related macular degeneration 13.27 12.99 5 22958 242 42598130
Renal tubular necrosis 13.19 12.99 30 22933 18324 42580048
Urethral injury 13.09 12.99 4 22959 101 42598271
Condition aggravated 13.05 12.99 205 22758 260549 42337823
Drug reaction with eosinophilia and systemic symptoms 13.04 12.99 51 22912 42024 42556348
Actinic keratosis 13.03 12.99 15 22948 5161 42593211

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 667.95 11.06 1031 61172 453059 110074037
Pulmonary vasculitis 270.62 11.06 111 62092 6449 110520647
Neuritis 261.02 11.06 112 62091 7287 110519809
Swollen tongue 257.80 11.06 237 61966 60125 110466971
Cellulitis 232.22 11.06 319 61884 125697 110401399
Type IV hypersensitivity reaction 218.36 11.06 93 62110 5940 110521156
Swelling face 209.48 11.06 259 61944 92062 110435034
Total lung capacity abnormal 207.80 11.06 83 62120 4500 110522596
Eosinophilic granulomatosis with polyangiitis 204.30 11.06 106 62097 10580 110516516
Neurological symptom 197.48 11.06 118 62085 15490 110511606
Cross sensitivity reaction 195.49 11.06 84 62119 5483 110521613
Loss of employment 185.09 11.06 70 62133 3274 110523822
Respiratory symptom 181.36 11.06 110 62093 14835 110512261
Mite allergy 179.24 11.06 80 62123 5723 110521373
Angioedema 177.90 11.06 247 61956 98253 110428843
Mycotic allergy 174.10 11.06 79 62124 5875 110521221
Dust allergy 173.50 11.06 79 62124 5922 110521174
Clostridium test positive 171.60 11.06 95 62108 10798 110516298
Spirometry abnormal 170.48 11.06 76 62127 5421 110521675
Conjunctivitis allergic 162.64 11.06 79 62124 6852 110520244
Dysphonia 162.64 11.06 207 61996 75722 110451374
Pulmonary alveolar haemorrhage 155.98 11.06 112 62091 20038 110507058
Obstructive airways disorder 148.07 11.06 155 62048 45994 110481102
Antineutrophil cytoplasmic antibody positive 147.31 11.06 67 62136 5009 110522087
Forced expiratory volume decreased 132.28 11.06 86 62117 13090 110514006
Rash 131.02 11.06 849 61354 820115 109706981
Normochromic normocytic anaemia 123.24 11.06 82 62121 12975 110514121
Urinary tract discomfort 119.20 11.06 37 62166 943 110526153
Urinary tract infection 117.58 11.06 427 61776 325855 110201241
Alveolar osteitis 115.50 11.06 37 62166 1048 110526048
Vasculitis 114.21 11.06 120 62083 35753 110491343
Synovitis 111.69 11.06 12 62191 274080 110253016
Pericarditis 105.65 11.06 4 62199 219110 110307986
Arteriosclerosis 105.23 11.06 97 62106 24670 110502426
Drug ineffective for unapproved indication 104.88 11.06 199 62004 102639 110424457
Hand deformity 102.01 11.06 5 62198 218501 110308595
Animal scratch 99.59 11.06 38 62165 1821 110525275
General physical health deterioration 99.30 11.06 58 62145 425237 110101859
Pemphigus 96.79 11.06 6 62197 214564 110312532
Systemic lupus erythematosus 96.65 11.06 14 62189 254324 110272772
Bladder pain 94.15 11.06 41 62162 2764 110524332
Tunnel vision 93.12 11.06 37 62166 1978 110525118
Arteriosclerosis coronary artery 90.82 11.06 90 62113 25028 110502068
Infusion related reaction 90.37 11.06 51 62152 381111 110145985
Oesophageal spasm 89.69 11.06 43 62160 3623 110523473
Ear congestion 80.69 11.06 40 62163 3625 110523471
Duodenal ulcer perforation 80.05 11.06 5 62198 177695 110349401
Capillaritis 79.75 11.06 35 62168 2404 110524692
Oesophageal pain 78.82 11.06 44 62159 5081 110522015
Full blood count abnormal 78.78 11.06 125 62078 55927 110471169
Skin laceration 78.62 11.06 96 62107 33657 110493439
Limb injury 76.48 11.06 100 62103 37536 110489560
Glossodynia 76.09 11.06 16 62187 221988 110305108
Nodule 69.91 11.06 89 62114 32542 110494554
Haemoptysis 68.97 11.06 135 62068 71219 110455877
Wound complication 68.67 11.06 43 62160 6134 110520962
Paranasal sinus discomfort 67.24 11.06 43 62160 6362 110520734
Wound secretion 66.72 11.06 44 62159 6857 110520239
Sleep disorder due to a general medical condition 66.17 11.06 111 62092 52001 110475095
Clostridium difficile infection 66.14 11.06 111 62092 52018 110475078
Sinus pain 65.54 11.06 41 62162 5838 110521258
Toxicity to various agents 63.43 11.06 108 62095 480447 110046649
Rheumatoid factor positive 61.47 11.06 3 62200 131637 110395459
Acute generalised exanthematous pustulosis 61.12 11.06 68 62135 21596 110505500
Anxiety 61.12 11.06 367 61836 344711 110182385
Hypothyroidism 61.07 11.06 130 62073 72769 110454327
Hepatic steatosis 60.66 11.06 103 62100 48728 110478368
Drug abuse 60.35 11.06 13 62190 177398 110349698
Polymyalgia rheumatica 57.30 11.06 39 62164 6403 110520693
Lymphoedema 56.78 11.06 55 62148 14874 110512222
Anaphylactic reaction 54.89 11.06 165 62038 114135 110412961
Type 2 diabetes mellitus 52.67 11.06 17 62186 177215 110349881
Irritable bowel syndrome 52.00 11.06 14 62189 164201 110362895
C-reactive protein abnormal 52.00 11.06 6 62197 129689 110397407
Rash maculo-papular 51.71 11.06 123 62080 74099 110452997
Alopecia 49.01 11.06 81 62122 364672 110162424
Folliculitis 48.22 11.06 17 62186 167636 110359460
Hypersensitivity 44.38 11.06 383 61820 403615 110123481
Bronchitis 43.95 11.06 190 62013 156842 110370254
Bronchopulmonary aspergillosis allergic 43.78 11.06 37 62166 8389 110518707
Calculus urinary 42.93 11.06 25 62178 3127 110523969
Localised infection 42.27 11.06 82 62121 42966 110484130
Myelosuppression 41.47 11.06 3 62200 94337 110432759
Emotional distress 41.11 11.06 83 62120 44764 110482332
Mobility decreased 40.76 11.06 44 62159 237378 110289718
Pollakiuria 40.75 11.06 82 62121 44113 110482983
Intentional product use issue 40.32 11.06 48 62155 247858 110279238
Arthropathy 39.41 11.06 63 62140 287459 110239637
Skin infection 38.46 11.06 55 62148 22454 110504642
Thrombosis 38.04 11.06 141 62062 108521 110418575
Psoriatic arthropathy 37.79 11.06 33 62170 196728 110330368
Febrile neutropenia 36.66 11.06 77 62126 316690 110210406
Nasal polyps 36.49 11.06 41 62162 13159 110513937
Cholecystitis chronic 36.13 11.06 35 62168 9465 110517631
Liver injury 35.79 11.06 20 62183 150393 110376703
Lip swelling 35.32 11.06 84 62119 50583 110476513
Cystitis 35.23 11.06 99 62104 65937 110461159
Sleep apnoea syndrome 34.88 11.06 73 62130 40374 110486722
Bursitis 34.35 11.06 15 62188 129903 110397193
Hypoaesthesia oral 34.27 11.06 45 62158 16957 110510139
Pruritus 34.13 11.06 487 61716 581073 109946023
Joint range of motion decreased 33.94 11.06 13 62190 121819 110405277
Hepatitis infectious mononucleosis 33.78 11.06 10 62193 216 110526880
Impaired healing 33.16 11.06 37 62166 196680 110330416
Diarrhoea 32.99 11.06 856 61347 1138649 109388447
Dysuria 32.82 11.06 91 62112 60140 110466956
Blood urine present 32.60 11.06 53 62150 24192 110502904
Productive cough 32.51 11.06 139 62064 114166 110412930
Hypokinesia 32.51 11.06 50 62153 21776 110505320
Chloropsia 32.08 11.06 7 62196 40 110527056
Inflammation 31.86 11.06 37 62166 193201 110333895
Uterine perforation 31.43 11.06 28 62175 6812 110520284
Opsoclonus myoclonus 31.32 11.06 10 62193 280 110526816
Pulmonary fibrosis 31.30 11.06 127 62076 101915 110425181
Drug reaction with eosinophilia and systemic symptoms 30.83 11.06 109 62094 81986 110445110
Immunosuppressant drug level decreased 30.07 11.06 19 62184 2752 110524344
Appetite disorder 29.88 11.06 32 62171 9737 110517359
Urticaria 29.78 11.06 292 61911 318565 110208531
Hepatic enzyme increased 29.35 11.06 88 62115 320804 110206292
Type I hypersensitivity 29.04 11.06 26 62177 6367 110520729
Pain in extremity 28.99 11.06 409 61794 486709 110040387
Peripheral venous disease 28.94 11.06 6 62197 84111 110442985
Clostridium difficile colitis 28.83 11.06 71 62132 43707 110483389
Hypoxia 28.40 11.06 146 62057 129369 110397727
Anaemia 28.20 11.06 186 62017 546900 109980196
Discomfort 27.61 11.06 49 62154 214658 110312438
Coma 27.57 11.06 16 62187 117853 110409243
Nephrolithiasis 27.57 11.06 91 62112 66121 110460975
Blood iron decreased 27.20 11.06 43 62160 19171 110507925
Panic attack 27.05 11.06 54 62149 28886 110498210
Thrombocytopenia 26.91 11.06 103 62100 348782 110178314
Ear pain 26.65 11.06 78 62125 53148 110473948
Arthritis infective 26.48 11.06 31 62172 10398 110516698
Renal tubular necrosis 26.27 11.06 55 62148 30420 110496676
Joint swelling 26.27 11.06 144 62059 442701 110084395
Rhabdomyolysis 25.89 11.06 18 62185 120383 110406713
Gastroenteritis bacterial 25.74 11.06 10 62193 503 110526593
Stevens-Johnson syndrome 25.69 11.06 71 62132 46830 110480266
Cardiac failure congestive 25.68 11.06 159 62044 150841 110376255
Prescribed overdose 24.98 11.06 9 62194 87572 110439524
Oral pain 24.94 11.06 61 62142 37383 110489713
Feeling cold 24.40 11.06 57 62146 33930 110493166
Burning sensation 24.38 11.06 90 62113 69122 110457974
Hepatic function abnormal 24.10 11.06 10 62193 89285 110437811
Musculoskeletal stiffness 23.99 11.06 79 62124 279743 110247353
Completed suicide 23.98 11.06 64 62139 242317 110284779
Erythema 23.93 11.06 260 61943 291187 110235909
Procedural pain 23.76 11.06 58 62145 35507 110491589
Product dose omission issue 23.69 11.06 281 61922 321501 110205595
Pigment nephropathy 23.63 11.06 6 62197 71 110527025
Maternal exposure during pregnancy 23.23 11.06 70 62133 254813 110272283
Swelling 23.16 11.06 110 62093 350931 110176165
Wound 23.12 11.06 62 62141 234375 110292721
Priapism 23.06 11.06 22 62181 5839 110521257
Obesity 23.01 11.06 18 62185 113333 110413763
Gastric disorder 22.93 11.06 55 62148 33302 110493794
Lower limb fracture 22.79 11.06 7 62196 75341 110451755
Illness 22.65 11.06 99 62104 82072 110445024
Skin ulcer 22.61 11.06 83 62120 63562 110463534
Hypoacusis 22.04 11.06 56 62147 35135 110491961
Dry mouth 21.97 11.06 50 62153 199898 110327198
Sinus disorder 21.47 11.06 53 62150 32675 110494421
Wrist fracture 21.43 11.06 33 62170 14384 110512712
Intentional overdose 21.17 11.06 26 62177 132475 110394621
Sciatica 20.97 11.06 13 62190 92386 110434710
Night sweats 20.67 11.06 27 62176 133956 110393140
Gallbladder disorder 20.57 11.06 40 62163 20989 110506107
C-reactive protein increased 20.47 11.06 59 62144 217860 110309236
Multiple lentigines syndrome 20.33 11.06 7 62196 249 110526847
Epilepsy 20.23 11.06 16 62187 100193 110426903
Blister infected 20.01 11.06 11 62192 1233 110525863
Headache 19.99 11.06 643 61560 881734 109645362
Diabetic retinal oedema 19.99 11.06 8 62195 436 110526660
Hallucination 19.95 11.06 111 62092 101321 110425775
Haematuria 19.91 11.06 96 62107 82909 110444187
Pulmonary embolism 19.81 11.06 196 62007 214278 110312818
Throat tightness 19.65 11.06 52 62151 33437 110493659
Dysphoria 19.56 11.06 21 62182 6407 110520689
Surgery 19.25 11.06 59 62144 41224 110485872
Multiple organ dysfunction syndrome 19.16 11.06 35 62168 151675 110375421
Rheumatoid arthritis 19.11 11.06 95 62108 299518 110227578
Myalgia 19.00 11.06 200 62003 222181 110304915
Movement disorder 18.85 11.06 54 62149 36350 110490746
Pyelonephritis 18.84 11.06 43 62160 25207 110501889
Skin cancer 18.84 11.06 35 62168 17749 110509347
Lactic acidosis 18.51 11.06 15 62188 92796 110434300
Joint injury 18.50 11.06 57 62146 39937 110487159
Neutropenia 18.47 11.06 129 62074 374491 110152605
Loss of personal independence in daily activities 18.46 11.06 146 62057 149874 110377222
Live birth 18.40 11.06 8 62195 69476 110457620
Nasopharyngitis 18.38 11.06 138 62065 394223 110132873
Musculoskeletal pain 18.35 11.06 48 62155 182975 110344121
Staphylococcal infection 18.32 11.06 83 62120 69861 110457235
Nail disorder 18.22 11.06 5 62198 57930 110469166
Skin warm 18.06 11.06 24 62179 9146 110517950
Skin exfoliation 17.97 11.06 97 62106 87554 110439542
Idiosyncratic drug reaction 17.85 11.06 11 62192 1525 110525571
Bronchiectasis 17.81 11.06 53 62150 36440 110490656
Red blood cell sedimentation rate increased 17.79 11.06 11 62192 78291 110448805
Osteomyelitis 17.72 11.06 53 62150 36547 110490549
Deep vein thrombosis 17.69 11.06 137 62066 139750 110387346
Implant site haematoma 17.66 11.06 6 62197 205 110526891
Hepatic cirrhosis 17.57 11.06 8 62195 67618 110459478
Tinnitus 17.50 11.06 74 62129 60466 110466630
Malignant neoplasm progression 17.33 11.06 46 62157 174521 110352575
Rales 17.23 11.06 41 62162 24698 110502398
Pharyngeal swelling 17.13 11.06 27 62176 12005 110515091
Chills 17.04 11.06 173 62030 190407 110336689
Gut fermentation syndrome 16.95 11.06 4 62199 34 110527062
Haemorrhagic diathesis 16.91 11.06 21 62182 7487 110519609
Blood cholesterol increased 16.65 11.06 51 62152 184734 110342362
Hepatocellular injury 16.64 11.06 4 62199 50638 110476458
Oedema 16.62 11.06 186 62017 209790 110317306
Taste disorder 16.58 11.06 8 62195 65379 110461717
Tenderness 16.56 11.06 45 62158 29392 110497704
Scab 16.54 11.06 28 62175 13208 110513888
Agranulocytosis 16.53 11.06 7 62196 61753 110465343
Hypercholesterolaemia 16.53 11.06 16 62187 90821 110436275
Drug interaction 16.43 11.06 191 62012 499992 110027104
Middle ear effusion 16.43 11.06 13 62190 2688 110524408
Delirium 16.31 11.06 32 62171 134993 110392103
Complement factor C4 increased 16.00 11.06 6 62197 274 110526822
Back pain 15.86 11.06 295 61908 370701 110156395
Cough 15.76 11.06 355 61848 461286 110065810
Pyelonephritis chronic 15.66 11.06 6 62197 291 110526805
Tinea infection 15.64 11.06 10 62193 1478 110525618
Autoimmune hepatitis 15.52 11.06 29 62174 14775 110512321
Pancytopenia 15.44 11.06 63 62140 209550 110317546
Chronic kidney disease 15.35 11.06 84 62119 76207 110450889
Dermatitis atopic 15.33 11.06 40 62163 25501 110501595
Pemphigoid 15.20 11.06 34 62169 19673 110507423
Abscess drainage 15.19 11.06 8 62195 823 110526273
Haemorrhoids thrombosed 15.18 11.06 6 62197 316 110526780
Autoimmune disorder 15.16 11.06 9 62194 65474 110461622
Tarsal tunnel syndrome 15.16 11.06 7 62196 542 110526554
Dyspnoea 15.13 11.06 764 61439 1106108 109420988
Product odour abnormal 15.08 11.06 10 62193 1573 110525523
Back injury 15.08 11.06 4 62199 47395 110479701
Coeliac disease 15.02 11.06 3 62200 43184 110483912
Drug intolerance 14.95 11.06 316 61887 406196 110120900
Actinic keratosis 14.82 11.06 19 62184 6994 110520102
Toxic epidermal necrolysis 14.62 11.06 67 62136 56660 110470436
Familial periodic paralysis 14.55 11.06 6 62197 353 110526743
Skin induration 14.52 11.06 15 62188 4380 110522716
Medication error 14.51 11.06 23 62180 105343 110421753
High frequency ablation 14.38 11.06 6 62197 364 110526732
Confusional state 14.24 11.06 182 62021 468498 110058598
Breast abscess 14.22 11.06 10 62193 1731 110525365
Leukopenia 14.18 11.06 40 62163 148751 110378345
Therapy cessation 13.89 11.06 56 62147 44801 110482295
Biliary sepsis 13.70 11.06 10 62193 1833 110525263
Tinea pedis 13.67 11.06 12 62191 2863 110524233
Drug ineffective 13.65 11.06 708 61495 1519832 109007264
Lymphopenia 13.54 11.06 3 62200 40167 110486929
Rash pruritic 13.50 11.06 98 62105 97971 110429125
Circumoral oedema 13.43 11.06 6 62197 430 110526666
Bone marrow failure 13.32 11.06 8 62195 57840 110469256
Fracture displacement 13.30 11.06 9 62194 1463 110525633
Metapneumovirus infection 13.25 11.06 11 62192 2433 110524663
Off label use 13.19 11.06 700 61503 1499485 109027611
Photophobia 13.12 11.06 38 62165 25733 110501363
Cardiogenic shock 13.10 11.06 8 62195 57330 110469766
Genital ulceration 13.09 11.06 10 62193 1965 110525131
Nasal herpes 12.97 11.06 7 62196 756 110526340
Ureteric obstruction 12.85 11.06 12 62191 3102 110523994
Drug dependence 12.83 11.06 59 62144 49961 110477135
Skin disorder 12.83 11.06 53 62150 42860 110484236
Fungal skin infection 12.81 11.06 18 62185 7231 110519865
Thinking abnormal 12.67 11.06 27 62176 15113 110511983
Oropharyngeal pain 12.67 11.06 124 62079 135152 110391944
Helicobacter duodenal ulcer 12.37 11.06 3 62200 29 110527067
Ill-defined disorder 12.28 11.06 46 62157 156807 110370289
Immune thrombocytopenia 12.27 11.06 34 62169 22460 110504636
Paradoxical pain 12.10 11.06 3 62200 32 110527064
Episcleritis 12.07 11.06 8 62195 1258 110525838
Blood creatine phosphokinase increased 12.03 11.06 14 62189 73063 110454033
Abscess limb 12.00 11.06 19 62184 8478 110518618
Incorrect route of product administration 11.99 11.06 11 62192 64050 110463046
Wheezing 11.98 11.06 206 61997 255024 110272072
Hypoglycaemia 11.98 11.06 30 62173 116074 110411022
Myopathy 11.94 11.06 36 62167 24924 110502172
Altered state of consciousness 11.89 11.06 9 62194 57617 110469479
Rheumatoid factor negative 11.87 11.06 8 62195 1292 110525804
Morbid thoughts 11.76 11.06 7 62196 912 110526184
Lower respiratory tract congestion 11.75 11.06 14 62189 4782 110522314
Incorrect dose administered 11.74 11.06 99 62104 103542 110423554
Influenza 11.70 11.06 146 62057 168955 110358141
Body temperature increased 11.52 11.06 61 62142 54652 110472444
Interstitial lung disease 11.48 11.06 40 62163 139294 110387802
Endocrine ophthalmopathy 11.48 11.06 8 62195 1365 110525731
Thermal burn 11.48 11.06 18 62185 7970 110519126
Purpura senile 11.47 11.06 6 62197 609 110526487
Pseudomonas infection 11.34 11.06 38 62165 27815 110499281
Gait inability 11.34 11.06 39 62164 136337 110390759
Bullous haemorrhagic dermatosis 11.14 11.06 5 62198 362 110526734
Eye infection 11.14 11.06 25 62178 14493 110512603
Cyst 11.12 11.06 27 62176 16469 110510627
Lip haemorrhage 11.07 11.06 8 62195 1444 110525652

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01DB01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
First-generation cephalosporins
FDA CS M0003827 Cephalosporins
FDA EPC N0000175488 Cephalosporin Antibacterial
CHEBI has role CHEBI:36047 antibacterial drug
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents

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J01DB First-generation cephalosporins 11 drugs
cefacetrilecefadroxilcefaloridinecefalotincefapirincefatrizinecefazedonecefazolincefradinecefroxadineceftezole

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute otitis media indication 3110003
Prostatitis indication 9713002 DOID:14654
Haemophilus Influenzae Acute Otitis Media indication 19021002
Infection of skin AND/OR subcutaneous tissue indication 19824006
Pneumonia due to Streptococcus indication 34020007
Streptococcal tonsillitis indication 41582007
Klebsiella cystitis indication 60867007
Infection of bone indication 111253001
Escherichia coli urinary tract infection indication 301011002
Proteus urinary tract infection indication 301012009
Streptococcus pyogenes infection indication 302809008
Bacterial urinary infection indication 312124009
Infective otitis media indication 312218008
Infectious disorder of joint indication 363162000
Infection due to Staphylococcus aureus indication 406602003
Osteomyelitis due to Staphylococcus aureus indication 428783003
Staphylococcus Acute Otitis Media indication 703469002
Moraxella Catarrhalis Acute Otitis Media indication 703469002
Klebsiella Prostatitis indication
Proteus Prostatitis indication
Streptococcus Osteomyelitis indication
Bacterial Mastitis off-label use
Prevention of Bacterial Endocarditis off-label use
Diabetic Foot Infection Due to Gram-Positive Bacteria off-label use
Colitis contraindication 64226004 DOID:0060180
Kidney disease contraindication 90708001 DOID:557
Pseudomembranous enterocolitis contraindication 397683000




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Secondary superficial bacterial pyoderma caused by Staphylococcus pseudintermedius Indication

🐶 Veterinary products

ProductApplicantIngredients
Rilexine Chewable Tablets Virbac AH Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.77 acidic
pKa2 13.53 acidic
pKa3 7.67 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Solute carrier family 15 member 2 Transporter IC50 4.38 WOMBAT-PK
Bacterial penicillin-binding protein Enzyme INHIBITOR CHEMBL CHEMBL
Penicillin-binding protein 3 Enzyme WOMBAT-PK

External reference:

IDSource
4018893 VUID
N0000179741 NUI
D00263 KEGG_DRUG
23325-78-2 SECONDARY_CAS_RN
1299782 RXNORM
C0007716 UMLSCUI
CHEBI:3534 CHEBI
Q53 PDB_CHEM_ID
CHEMBL1727 ChEMBL_ID
CHEMBL1200544 ChEMBL_ID
CHEMBL1200366 ChEMBL_ID
DB00567 DRUGBANK_ID
105879-42-3 SECONDARY_CAS_RN
27447 PUBCHEM_CID
4393 MMSL
d00096 MMSL
002716 NDDF
002717 NDDF
387304003 SNOMEDCT_US
54062005 SNOMEDCT_US
54887004 SNOMEDCT_US
785690001 SNOMEDCT_US
D002506 MESH_DESCRIPTOR_UI
4832 IUPHAR_LIGAND_ID
2400 INN_ID
4018891 VANDF
4018893 VANDF
OBN7UDS42Y UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 0093-2238 TABLET 250 mg ORAL ANDA 19 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 0093-2238 TABLET 250 mg ORAL ANDA 19 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 0093-2240 TABLET 500 mg ORAL ANDA 19 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 0093-2240 TABLET 500 mg ORAL ANDA 19 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 0093-3145 CAPSULE 250 mg ORAL ANDA 23 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 0093-3147 CAPSULE 500 mg ORAL ANDA 23 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 0093-4175 POWDER, FOR SUSPENSION 125 mg ORAL ANDA 23 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 0093-4177 POWDER, FOR SUSPENSION 250 mg ORAL ANDA 23 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 0440-1243 CAPSULE 250 mg ORAL ANDA 19 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 0440-7244 CAPSULE 500 mg ORAL ANDA 23 sections
Cephalexin Human Prescription Drug Label 1 0904-7336 CAPSULE 250 mg ORAL ANDA 23 sections
Cephalexin Human Prescription Drug Label 1 0904-7337 CAPSULE 500 mg ORAL ANDA 23 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 10544-004 CAPSULE 500 mg ORAL ANDA 23 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 10544-013 CAPSULE 500 mg ORAL ANDA 24 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 10544-020 CAPSULE 500 mg ORAL ANDA 23 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 10544-021 CAPSULE 250 mg ORAL ANDA 24 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 10544-025 CAPSULE 500 mg ORAL ANDA 24 sections
cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 10544-057 CAPSULE 500 mg ORAL ANDA 24 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 10544-066 CAPSULE 250 mg ORAL ANDA 19 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 10544-082 CAPSULE 500 mg ORAL ANDA 21 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 10544-142 CAPSULE 250 mg ORAL ANDA 23 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 10544-503 CAPSULE 500 mg ORAL ANDA 13 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 10544-529 CAPSULE 500 mg ORAL ANDA 22 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 10544-617 CAPSULE 500 mg ORAL ANDA 19 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 10544-868 CAPSULE 250 mg ORAL ANDA 21 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 10544-945 CAPSULE 500 mg ORAL ANDA 25 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 10544-946 CAPSULE 250 mg ORAL ANDA 25 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 10544-979 CAPSULE 250 mg ORAL ANDA 22 sections
cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 12634-434 CAPSULE 500 mg ORAL ANDA 20 sections
Cephalexin HUMAN PRESCRIPTION DRUG LABEL 1 15749-801 CAPSULE 250 mg ORAL ANDA 22 sections