iron dextran 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	5562	9004-66-4

Description:

Molecule	Description
Molfile Synonyms: iron dextran iron dextran complex imferon	A complex of ferric oxyhydroxide with dextrans of 5000 to 7000 daltons in viscous solution containing 50 mg/ml of iron. It is supplied as parenteral preparation and is used as hematinic. (Goodman and Gilmans The Pharmacological Basis of Therapeutics, 8th ed, p1292) Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Molfile

Synonyms:

iron dextran
iron dextran complex
imferon

A complex of ferric oxyhydroxide with dextrans of 5000 to 7000 daltons in viscous solution containing 50 mg/ml of iron. It is supplied as parenteral preparation and is used as hematinic. (Goodman and Gilmans The Pharmacological Basis of Therapeutics, 8th ed, p1292)

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dyspnoea	74.50	24.78	116	2690	661197	62825019
Flushing	63.13	24.78	40	2766	75047	63411169
Throat tightness	51.18	24.78	24	2782	24863	63461353
Calciphylaxis	51.07	24.78	14	2792	3058	63483158
Infusion related reaction	48.78	24.78	57	2749	245464	63240752
Central nervous system injury	41.70	24.78	7	2799	144	63486072
Chest pain	40.98	24.78	49	2757	215910	63270306
Back pain	40.70	24.78	54	2752	264091	63222125
Anaphylactic reaction	40.61	24.78	29	2777	66071	63420145
Splenic injury	39.07	24.78	7	2799	213	63486003
Hypochromasia	35.79	24.78	7	2799	345	63485871
Chest discomfort	35.21	24.78	33	2773	109936	63376280
Anisocytosis	30.82	24.78	7	2799	711	63485505
Hyperchloraemia	30.39	24.78	7	2799	756	63485460
Hyperaemia	27.18	24.78	8	2798	2251	63483965
Throat irritation	26.57	24.78	18	2788	37629	63448587
Toxoplasmosis	25.59	24.78	7	2799	1516	63484700

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Infusion related reaction	59.24	27.28	31	1161	53026	34902713
Anaphylactic reaction	54.40	27.28	25	1167	32276	34923463
Dyspnoea	32.78	27.28	51	1141	376731	34579008

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Infusion related reaction	101.16	24.37	79	3093	230158	79511058
Anaphylactic reaction	78.39	24.37	46	3126	83697	79657519
Dyspnoea	75.51	24.37	127	3045	856898	78884318
Flushing	73.57	24.37	45	3127	88223	79652993
Back pain	51.80	24.37	62	3110	304118	79437098
Throat tightness	50.96	24.37	24	3148	27883	79713333
Central nervous system injury	41.91	24.37	7	3165	156	79741060
Chest discomfort	41.17	24.37	38	3134	138006	79603210
Splenic injury	38.33	24.37	7	3165	265	79740951
Chest pain	37.66	24.37	51	3121	282253	79458963
Throat irritation	34.38	24.37	21	3151	40925	79700291
Drug ineffective	32.26	24.37	3	3169	1080910	78660306
Hypochromasia	31.77	24.37	7	3165	689	79740527
Anisocytosis	28.97	24.37	7	3165	1032	79740184
Hyperchloraemia	28.45	24.37	7	3165	1114	79740102
Feeling hot	25.03	24.37	20	3152	59714	79681502

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D006397	Hematinics
MeSH PA	D006401	Hematologic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

Species	Use	Relation
Swine	Iron deficiency anemia	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Nonemic	Intervet Inc.	1
Ferrextran 100	Zoetis Inc.	1
Rubrafer, Rubrafer S-100	Zoetis Inc.	1
Imposil	Ceva Sante Animale	1
Uniferon 100	Pharmacosmos Inc.	1
PVL Iron Dextran Injectable	Huvepharma EOOD	1
Uniferon 200	Pharmacosmos Inc.	1
Iron Hydrogenated Dextran Injection	Sparhawk Laboratories Inc.	1
Iron Dextran Injection, Iron Dextran Injection 100mg	Huvepharma EOOD	1
Iron Dextran Injection - 200	Huvepharma EOOD	1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
CHEBI:78291	CHEBI
CHEMBL1201544	ChEMBL_ID
CHEMBL4802224	ChEMBL_ID
DB00893	DRUGBANK_ID
000832	NDDF
4018581	VANDF
4022439	VANDF
C0022092	UMLSCUI
21767006	SNOMEDCT_US
387118003	SNOMEDCT_US
C13774	KEGG_DRUG
105075	PUBCHEM_CID
5992	RXNORM
4922	MMSL
d03767	MMSL
D007505	MESH_DESCRIPTOR_UI
95HR524N2M	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
INFeD	HUMAN PRESCRIPTION DRUG LABEL	1	0023-6082	INJECTION	50 mg	INTRAMUSCULAR	NDA	26 sections
INFeD	HUMAN PRESCRIPTION DRUG LABEL	1	0023-6082	INJECTION	50 mg	INTRAMUSCULAR	NDA	26 sections
INFED	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9879	INJECTION	50 mg	INTRAMUSCULAR	NDA	20 sections
INFED	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9879	INJECTION	50 mg	INTRAMUSCULAR	NDA	20 sections
INFED	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9879	INJECTION	50 mg	INTRAMUSCULAR	NDA	20 sections
Se-Tan PLUS	HUMAN PRESCRIPTION DRUG LABEL	13	13925-118	CAPSULE, GELATIN COATED	115.20 mg	ORAL	unapproved drug other	19 sections
Se-Tan PLUS	HUMAN PRESCRIPTION DRUG LABEL	13	13925-118	CAPSULE, GELATIN COATED	115.20 mg	ORAL	unapproved drug other	19 sections
IRON DEXTRAN	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1441	INJECTION	50 mg	INTRAMUSCULAR	NDA	13 sections
INFED	HUMAN PRESCRIPTION DRUG LABEL	1	52584-086	INJECTION	50 mg	INTRAMUSCULAR	NDA	20 sections
INFED	HUMAN PRESCRIPTION DRUG LABEL	1	52584-086	INJECTION	50 mg	INTRAMUSCULAR	NDA	20 sections
INFED	HUMAN PRESCRIPTION DRUG LABEL	1	52584-086	INJECTION	50 mg	INTRAMUSCULAR	NDA	20 sections
PureVit DualFe Plus	HUMAN PRESCRIPTION DRUG LABEL	13	59088-112	CAPSULE	53 mg	ORAL	unapproved drug other	12 sections
PureVit DualFe Plus	HUMAN PRESCRIPTION DRUG LABEL	13	59088-112	CAPSULE	53 mg	ORAL	unapproved drug other	12 sections
Niferex	HUMAN PRESCRIPTION DRUG LABEL	9	75854-321	TABLET	100 mg	ORAL	unapproved drug other	12 sections