Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, cefalosporanic acid derivatives | 530 | 25953-19-9 |
Dose | Unit | Route |
---|---|---|
3 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 33 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 80 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 146.75 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 0 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.12 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.89 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.18 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.70 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Oct. 4, 1973 | FDA | GLAXOSMITHKLINE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Anaphylactic shock | 604.84 | 13.98 | 226 | 15660 | 23407 | 63449729 |
Anaphylactic reaction | 279.14 | 13.98 | 185 | 15701 | 65915 | 63407221 |
Hypotension | 196.57 | 13.98 | 288 | 15598 | 272316 | 63200820 |
Acute generalised exanthematous pustulosis | 178.45 | 13.98 | 76 | 15810 | 11023 | 63462113 |
Arthrodesis | 155.65 | 13.98 | 48 | 15838 | 2753 | 63470383 |
Postoperative wound infection | 115.93 | 13.98 | 56 | 15830 | 10869 | 63462267 |
Fatigue | 95.60 | 13.98 | 52 | 15834 | 887976 | 62585160 |
Bronchospasm | 91.84 | 13.98 | 56 | 15830 | 17224 | 63455912 |
Erythema | 83.37 | 13.98 | 154 | 15732 | 175597 | 63297539 |
Type I hypersensitivity | 81.99 | 13.98 | 30 | 15856 | 2912 | 63470224 |
Exposure during pregnancy | 73.37 | 13.98 | 136 | 15750 | 155411 | 63317725 |
Urticaria | 70.85 | 13.98 | 139 | 15747 | 165663 | 63307473 |
Cardiac arrest | 66.72 | 13.98 | 98 | 15788 | 92447 | 63380689 |
Tachycardia | 64.30 | 13.98 | 110 | 15776 | 118046 | 63355090 |
Vitamin K deficiency | 63.78 | 13.98 | 16 | 15870 | 424 | 63472712 |
Drug hypersensitivity | 63.44 | 13.98 | 196 | 15690 | 310491 | 63162645 |
Shoulder arthroplasty | 59.70 | 13.98 | 26 | 15860 | 3976 | 63469160 |
Premature delivery | 59.70 | 13.98 | 54 | 15832 | 30227 | 63442909 |
Premature baby | 59.62 | 13.98 | 46 | 15840 | 20689 | 63452447 |
Amniotic cavity infection | 59.16 | 13.98 | 19 | 15867 | 1244 | 63471892 |
Limb operation | 56.28 | 13.98 | 25 | 15861 | 4006 | 63469130 |
Drug-induced liver injury | 55.48 | 13.98 | 59 | 15827 | 40163 | 63432973 |
Hypoprothrombinaemia | 54.48 | 13.98 | 13 | 15873 | 278 | 63472858 |
Blood pressure decreased | 52.96 | 13.98 | 73 | 15813 | 64949 | 63408187 |
Renal failure | 51.88 | 13.98 | 100 | 15786 | 117552 | 63355584 |
Kounis syndrome | 49.54 | 13.98 | 18 | 15868 | 1712 | 63471424 |
Anaesthetic complication | 47.35 | 13.98 | 18 | 15868 | 1942 | 63471194 |
Alopecia | 47.29 | 13.98 | 13 | 15873 | 337523 | 63135613 |
Bradycardia | 44.95 | 13.98 | 72 | 15814 | 73155 | 63399981 |
Drug intolerance | 44.93 | 13.98 | 11 | 15875 | 308650 | 63164486 |
Maternal exposure during delivery | 44.42 | 13.98 | 16 | 15870 | 1484 | 63471652 |
Renal injury | 43.62 | 13.98 | 28 | 15858 | 9411 | 63463725 |
Rash | 41.74 | 13.98 | 261 | 15625 | 560610 | 62912526 |
Coagulopathy | 41.20 | 13.98 | 37 | 15849 | 20507 | 63452629 |
Recurrence of neuromuscular blockade | 40.72 | 13.98 | 9 | 15877 | 135 | 63473001 |
Toxic epidermal necrolysis | 40.06 | 13.98 | 40 | 15846 | 25294 | 63447842 |
Acute hepatic failure | 38.73 | 13.98 | 34 | 15852 | 18293 | 63454843 |
Vascular purpura | 37.25 | 13.98 | 14 | 15872 | 1464 | 63471672 |
Fear | 36.88 | 13.98 | 31 | 15855 | 15735 | 63457401 |
Multiple organ dysfunction syndrome | 36.48 | 13.98 | 57 | 15829 | 56695 | 63416441 |
Systemic lupus erythematosus | 35.61 | 13.98 | 5 | 15881 | 208913 | 63264223 |
Anhedonia | 35.21 | 13.98 | 26 | 15860 | 10948 | 63462188 |
Product dose omission issue | 34.78 | 13.98 | 8 | 15878 | 234305 | 63238831 |
Headache | 34.04 | 13.98 | 67 | 15819 | 633174 | 62839962 |
Generalised tonic-clonic seizure | 33.86 | 13.98 | 39 | 15847 | 28977 | 63444159 |
Pseudomembranous colitis | 33.15 | 13.98 | 16 | 15870 | 3096 | 63470040 |
Weight increased | 33.02 | 13.98 | 12 | 15874 | 260780 | 63212356 |
Purpura senile | 32.77 | 13.98 | 10 | 15876 | 553 | 63472583 |
Post procedural complication | 32.77 | 13.98 | 30 | 15856 | 17044 | 63456092 |
Tarsal tunnel syndrome | 32.58 | 13.98 | 10 | 15876 | 564 | 63472572 |
Peripheral swelling | 32.41 | 13.98 | 13 | 15873 | 265929 | 63207207 |
Unevaluable event | 32.18 | 13.98 | 51 | 15835 | 51335 | 63421801 |
Isoimmune haemolytic disease | 31.95 | 13.98 | 6 | 15880 | 37 | 63473099 |
Disseminated intravascular coagulation | 31.83 | 13.98 | 31 | 15855 | 19020 | 63454116 |
Hepatic function abnormal | 30.68 | 13.98 | 42 | 15844 | 37100 | 63436036 |
Face oedema | 30.29 | 13.98 | 31 | 15855 | 20181 | 63452955 |
Cholestasis | 30.12 | 13.98 | 37 | 15849 | 29397 | 63443739 |
Wound | 30.06 | 13.98 | 3 | 15883 | 163260 | 63309876 |
Clostridium test positive | 29.76 | 13.98 | 15 | 15871 | 3186 | 63469950 |
Swelling | 29.63 | 13.98 | 16 | 15870 | 275362 | 63197774 |
Sinusitis | 29.43 | 13.98 | 10 | 15876 | 226643 | 63246493 |
Thrombotic microangiopathy | 29.42 | 13.98 | 23 | 15863 | 10538 | 63462598 |
Oxygen saturation decreased | 29.34 | 13.98 | 67 | 15819 | 88518 | 63384618 |
Angioedema | 29.20 | 13.98 | 47 | 15839 | 47918 | 63425218 |
Joint swelling | 28.61 | 13.98 | 24 | 15862 | 327642 | 63145494 |
Therapeutic product effect decreased | 27.87 | 13.98 | 7 | 15879 | 193180 | 63279956 |
Acute kidney injury | 27.85 | 13.98 | 135 | 15751 | 263280 | 63209856 |
Foetal anaemia | 26.79 | 13.98 | 6 | 15880 | 96 | 63473040 |
Pain | 26.43 | 13.98 | 96 | 15790 | 740532 | 62732604 |
Hepatitis cholestatic | 25.98 | 13.98 | 18 | 15868 | 6860 | 63466276 |
Pain in extremity | 25.74 | 13.98 | 27 | 15859 | 331459 | 63141677 |
Toxic skin eruption | 25.43 | 13.98 | 23 | 15863 | 12862 | 63460274 |
Death | 25.33 | 13.98 | 34 | 15852 | 374347 | 63098789 |
Hyperthermia malignant | 25.09 | 13.98 | 9 | 15877 | 825 | 63472311 |
Post procedural haematoma | 24.70 | 13.98 | 10 | 15876 | 1275 | 63471861 |
Malaise | 24.09 | 13.98 | 42 | 15844 | 415912 | 63057224 |
Infusion related reaction | 23.97 | 13.98 | 16 | 15870 | 245505 | 63227631 |
Haemolytic anaemia | 23.87 | 13.98 | 20 | 15866 | 10105 | 63463031 |
Treatment failure | 23.80 | 13.98 | 10 | 15876 | 199033 | 63274103 |
Tonic clonic movements | 23.63 | 13.98 | 10 | 15876 | 1425 | 63471711 |
Altered state of consciousness | 23.09 | 13.98 | 30 | 15856 | 25200 | 63447936 |
Pleural effusion | 22.98 | 13.98 | 63 | 15823 | 93147 | 63379989 |
Implant site haematoma | 22.50 | 13.98 | 5 | 15881 | 77 | 63473059 |
Eosinophilia | 22.31 | 13.98 | 28 | 15858 | 22728 | 63450408 |
Heparin-induced thrombocytopenia | 22.19 | 13.98 | 14 | 15872 | 4568 | 63468568 |
Resorption bone increased | 21.39 | 13.98 | 9 | 15877 | 1265 | 63471871 |
Low birth weight baby | 20.89 | 13.98 | 16 | 15870 | 7113 | 63466023 |
Injury | 20.59 | 13.98 | 52 | 15834 | 73195 | 63399941 |
Nasopharyngitis | 20.54 | 13.98 | 20 | 15866 | 254237 | 63218899 |
Drug reaction with eosinophilia and systemic symptoms | 20.38 | 13.98 | 33 | 15853 | 33803 | 63439333 |
Vestibular disorder | 20.38 | 13.98 | 9 | 15877 | 1422 | 63471714 |
Aspartate aminotransferase increased | 20.28 | 13.98 | 59 | 15827 | 90218 | 63382918 |
Pulseless electrical activity | 20.13 | 13.98 | 16 | 15870 | 7505 | 63465631 |
Shock | 20.08 | 13.98 | 27 | 15859 | 23436 | 63449700 |
Staphylococcal bacteraemia | 19.79 | 13.98 | 14 | 15872 | 5516 | 63467620 |
Asthenia | 19.36 | 13.98 | 42 | 15844 | 383562 | 63089574 |
Mixed liver injury | 19.33 | 13.98 | 13 | 15873 | 4722 | 63468414 |
Post procedural haemorrhage | 19.33 | 13.98 | 16 | 15870 | 7948 | 63465188 |
Eyelid oedema | 19.31 | 13.98 | 18 | 15868 | 10461 | 63462675 |
Hypoventilation | 19.28 | 13.98 | 13 | 15873 | 4741 | 63468395 |
Clostridium difficile infection | 19.14 | 13.98 | 30 | 15856 | 29892 | 63443244 |
Pyomyositis | 19.04 | 13.98 | 6 | 15880 | 369 | 63472767 |
Lip oedema | 19.02 | 13.98 | 12 | 15874 | 3912 | 63469224 |
Arthralgia | 18.89 | 13.98 | 76 | 15810 | 569634 | 62903502 |
Alanine aminotransferase increased | 18.85 | 13.98 | 63 | 15823 | 103707 | 63369429 |
Hypokalaemia | 18.84 | 13.98 | 63 | 15823 | 103741 | 63369395 |
Laryngeal dyspnoea | 18.59 | 13.98 | 5 | 15881 | 175 | 63472961 |
Hepatic cytolysis | 18.46 | 13.98 | 21 | 15865 | 15386 | 63457750 |
Spinal cord haematoma | 18.46 | 13.98 | 5 | 15881 | 180 | 63472956 |
Eosinophilic pneumonia acute | 18.29 | 13.98 | 6 | 15880 | 420 | 63472716 |
Shock haemorrhagic | 18.24 | 13.98 | 17 | 15869 | 9878 | 63463258 |
Manipulation | 18.23 | 13.98 | 4 | 15882 | 58 | 63473078 |
Cerebral infarction | 18.21 | 13.98 | 26 | 15860 | 23867 | 63449269 |
Injection site pain | 18.15 | 13.98 | 5 | 15881 | 129795 | 63343341 |
Musculoskeletal stiffness | 18.06 | 13.98 | 12 | 15874 | 184606 | 63288530 |
Mycobacterial peritonitis | 18.04 | 13.98 | 4 | 15882 | 61 | 63473075 |
Oligohydramnios | 18.03 | 13.98 | 14 | 15872 | 6352 | 63466784 |
Allergy test negative | 17.97 | 13.98 | 5 | 15881 | 199 | 63472937 |
Respiratory failure | 17.76 | 13.98 | 61 | 15825 | 101797 | 63371339 |
Glomerular filtration rate abnormal | 17.76 | 13.98 | 7 | 15879 | 832 | 63472304 |
Procedural complication | 17.70 | 13.98 | 13 | 15873 | 5426 | 63467710 |
Abdominal wound dehiscence | 17.49 | 13.98 | 5 | 15881 | 220 | 63472916 |
Haemodynamic instability | 17.34 | 13.98 | 16 | 15870 | 9174 | 63463962 |
Emotional distress | 17.28 | 13.98 | 30 | 15856 | 32519 | 63440617 |
Device related infection | 17.16 | 13.98 | 25 | 15861 | 23367 | 63449769 |
Deep vein thrombosis | 17.15 | 13.98 | 53 | 15833 | 83747 | 63389389 |
Linear IgA disease | 17.11 | 13.98 | 8 | 15878 | 1443 | 63471693 |
Circulatory collapse | 16.91 | 13.98 | 24 | 15862 | 21914 | 63451222 |
Weight decreased | 16.88 | 13.98 | 27 | 15859 | 276771 | 63196365 |
Gastrointestinal disorder | 16.66 | 13.98 | 6 | 15880 | 131233 | 63341903 |
Clostridium difficile colitis | 16.59 | 13.98 | 23 | 15863 | 20546 | 63452590 |
Jaundice acholuric | 16.44 | 13.98 | 4 | 15882 | 93 | 63473043 |
Anaemia | 16.11 | 13.98 | 127 | 15759 | 293303 | 63179833 |
Intentional product use issue | 15.98 | 13.98 | 6 | 15880 | 127886 | 63345250 |
Decorticate posture | 15.96 | 13.98 | 5 | 15881 | 302 | 63472834 |
Dizziness | 15.77 | 13.98 | 55 | 15831 | 429870 | 63043266 |
Renal impairment | 15.48 | 13.98 | 53 | 15833 | 88302 | 63384834 |
Therapeutic product effect incomplete | 15.40 | 13.98 | 6 | 15880 | 125050 | 63348086 |
Irregular breathing | 15.34 | 13.98 | 5 | 15881 | 343 | 63472793 |
Arthrofibrosis | 15.30 | 13.98 | 3 | 15883 | 24 | 63473112 |
Apnoea | 15.20 | 13.98 | 14 | 15872 | 8008 | 63465128 |
Toxicity to various agents | 15.19 | 13.98 | 24 | 15862 | 247226 | 63225910 |
Insomnia | 15.10 | 13.98 | 19 | 15867 | 215233 | 63257903 |
Discomfort | 14.91 | 13.98 | 12 | 15874 | 167362 | 63305774 |
Peritoneal cloudy effluent | 14.88 | 13.98 | 4 | 15882 | 140 | 63472996 |
Brain oedema | 14.77 | 13.98 | 18 | 15868 | 14177 | 63458959 |
Renal vein thrombosis | 14.63 | 13.98 | 5 | 15881 | 397 | 63472739 |
Mobility decreased | 14.62 | 13.98 | 6 | 15880 | 121153 | 63351983 |
Multiple lentigines syndrome | 14.51 | 13.98 | 4 | 15882 | 154 | 63472982 |
Hypopnoea | 14.47 | 13.98 | 10 | 15876 | 3796 | 63469340 |
Septic shock | 14.44 | 13.98 | 43 | 15843 | 66586 | 63406550 |
Atelectasis | 14.39 | 13.98 | 22 | 15864 | 21461 | 63451675 |
Hypoxia | 14.32 | 13.98 | 40 | 15846 | 59752 | 63413384 |
Delivery | 14.30 | 13.98 | 7 | 15879 | 1396 | 63471740 |
Keratitis fungal | 14.29 | 13.98 | 4 | 15882 | 163 | 63472973 |
Serratia test positive | 14.27 | 13.98 | 3 | 15883 | 35 | 63473101 |
Bradycardia foetal | 14.24 | 13.98 | 5 | 15881 | 431 | 63472705 |
Muscle spasms | 14.15 | 13.98 | 11 | 15875 | 156139 | 63316997 |
Endotracheal intubation complication | 14.11 | 13.98 | 5 | 15881 | 442 | 63472694 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Anaphylactic shock | 391.99 | 14.89 | 169 | 13831 | 15772 | 34927159 |
Anaphylactic reaction | 273.97 | 14.89 | 167 | 13833 | 32134 | 34910797 |
Hypoprothrombinaemia | 160.79 | 14.89 | 36 | 13964 | 346 | 34942585 |
Kounis syndrome | 97.35 | 14.89 | 37 | 13963 | 2481 | 34940450 |
Fear | 96.01 | 14.89 | 57 | 13943 | 10419 | 34932512 |
Drug reaction with eosinophilia and systemic symptoms | 82.87 | 14.89 | 83 | 13917 | 32929 | 34910002 |
Thymus hypoplasia | 80.65 | 14.89 | 21 | 13979 | 397 | 34942534 |
Lymphoid tissue hypoplasia | 80.65 | 14.89 | 21 | 13979 | 397 | 34942534 |
Hypotension | 79.42 | 14.89 | 231 | 13769 | 221418 | 34721513 |
Renal injury | 75.14 | 14.89 | 50 | 13950 | 11145 | 34931786 |
Anhedonia | 74.05 | 14.89 | 43 | 13957 | 7542 | 34935389 |
Injury | 73.20 | 14.89 | 63 | 13937 | 20624 | 34922307 |
Acute generalised exanthematous pustulosis | 73.09 | 14.89 | 41 | 13959 | 6735 | 34936196 |
Disseminated aspergillosis | 67.70 | 14.89 | 21 | 13979 | 759 | 34942172 |
Emotional distress | 61.95 | 14.89 | 50 | 13950 | 14976 | 34927955 |
Clostridium difficile colitis | 59.94 | 14.89 | 50 | 13950 | 15680 | 34927251 |
Fatigue | 59.10 | 14.89 | 38 | 13962 | 370615 | 34572316 |
Bronchospasm | 55.82 | 14.89 | 41 | 13959 | 10690 | 34932241 |
Vitamin K deficiency | 54.20 | 14.89 | 14 | 13986 | 256 | 34942675 |
Allergy test negative | 53.25 | 14.89 | 12 | 13988 | 119 | 34942812 |
Urticaria | 53.08 | 14.89 | 92 | 13908 | 62285 | 34880646 |
Hypovitaminosis | 51.43 | 14.89 | 16 | 13984 | 584 | 34942347 |
Erythema | 46.62 | 14.89 | 107 | 13893 | 88673 | 34854258 |
Clostridium test positive | 43.77 | 14.89 | 23 | 13977 | 3319 | 34939612 |
Unevaluable event | 43.14 | 14.89 | 59 | 13941 | 32531 | 34910400 |
Brain herniation | 42.54 | 14.89 | 24 | 13976 | 3984 | 34938947 |
Post procedural hypotension | 42.36 | 14.89 | 9 | 13991 | 66 | 34942865 |
Death | 41.14 | 14.89 | 60 | 13940 | 397989 | 34544942 |
Post procedural complication | 40.92 | 14.89 | 35 | 13965 | 11353 | 34931578 |
Vitamin K decreased | 39.33 | 14.89 | 8 | 13992 | 46 | 34942885 |
Dizziness | 38.16 | 14.89 | 20 | 13980 | 218501 | 34724430 |
Tubulointerstitial nephritis | 37.22 | 14.89 | 44 | 13956 | 20980 | 34921951 |
Cytomegalovirus viraemia | 35.54 | 14.89 | 27 | 13973 | 7403 | 34935528 |
Rash maculo-papular | 35.39 | 14.89 | 50 | 13950 | 28401 | 34914530 |
Blood pressure decreased | 35.02 | 14.89 | 69 | 13931 | 51446 | 34891485 |
Rash | 34.45 | 14.89 | 178 | 13822 | 222574 | 34720357 |
Coagulopathy | 34.35 | 14.89 | 41 | 13959 | 19748 | 34923183 |
Shock | 33.86 | 14.89 | 45 | 13955 | 24134 | 34918797 |
Weight decreased | 32.48 | 14.89 | 15 | 13985 | 176286 | 34766645 |
Hyperthermia malignant | 31.44 | 14.89 | 16 | 13984 | 2161 | 34940770 |
Adrenal suppression | 30.50 | 14.89 | 11 | 13989 | 636 | 34942295 |
Post procedural haematoma | 30.46 | 14.89 | 14 | 13986 | 1512 | 34941419 |
Gastritis fungal | 29.77 | 14.89 | 7 | 13993 | 85 | 34942846 |
Metabolic acidosis | 29.07 | 14.89 | 58 | 13942 | 43622 | 34899309 |
Jaundice cholestatic | 28.80 | 14.89 | 20 | 13980 | 4774 | 34938157 |
Renal failure | 28.07 | 14.89 | 115 | 13885 | 130442 | 34812489 |
Pathogen resistance | 27.83 | 14.89 | 26 | 13974 | 9456 | 34933475 |
Coagulation factor X level decreased | 27.45 | 14.89 | 5 | 13995 | 14 | 34942917 |
Linear IgA disease | 26.58 | 14.89 | 13 | 13987 | 1613 | 34941318 |
Multiple organ dysfunction syndrome | 26.51 | 14.89 | 79 | 13921 | 76487 | 34866444 |
Ventricular tachycardia | 26.33 | 14.89 | 42 | 13958 | 26537 | 34916394 |
Pericarditis fungal | 25.83 | 14.89 | 7 | 13993 | 155 | 34942776 |
Eosinophilia | 25.38 | 14.89 | 41 | 13959 | 26181 | 34916750 |
Angioedema | 25.32 | 14.89 | 50 | 13950 | 37324 | 34905607 |
Renal impairment | 25.04 | 14.89 | 89 | 13911 | 94424 | 34848507 |
Serotonin syndrome | 24.74 | 14.89 | 35 | 13965 | 19898 | 34923033 |
Fungal infection | 24.40 | 14.89 | 31 | 13969 | 15904 | 34927027 |
Pseudomonal sepsis | 24.17 | 14.89 | 16 | 13984 | 3531 | 34939400 |
Device related infection | 24.01 | 14.89 | 32 | 13968 | 17205 | 34925726 |
Hepatic function abnormal | 23.84 | 14.89 | 54 | 13946 | 44309 | 34898622 |
Rash morbilliform | 23.68 | 14.89 | 15 | 13985 | 3072 | 34939859 |
Stress | 23.52 | 14.89 | 43 | 13957 | 30304 | 34912627 |
Meningitis fungal | 23.27 | 14.89 | 6 | 13994 | 109 | 34942822 |
Embolic stroke | 23.12 | 14.89 | 17 | 13983 | 4437 | 34938494 |
Strongyloidiasis | 22.89 | 14.89 | 14 | 13986 | 2697 | 34940234 |
Type I hypersensitivity | 22.77 | 14.89 | 11 | 13989 | 1328 | 34941603 |
Toxic epidermal necrolysis | 22.54 | 14.89 | 35 | 13965 | 21611 | 34921320 |
Burkholderia test positive | 22.36 | 14.89 | 10 | 13990 | 1013 | 34941918 |
Product dose omission issue | 22.32 | 14.89 | 10 | 13990 | 119701 | 34823230 |
Malaise | 22.24 | 14.89 | 25 | 13975 | 185800 | 34757131 |
Arterial angioplasty | 22.15 | 14.89 | 5 | 13995 | 50 | 34942881 |
Drug eruption | 21.88 | 14.89 | 33 | 13967 | 19865 | 34923066 |
Toxicity to various agents | 21.82 | 14.89 | 29 | 13971 | 200333 | 34742598 |
Diarrhoea | 21.54 | 14.89 | 82 | 13918 | 389830 | 34553101 |
Myoclonus | 21.53 | 14.89 | 28 | 13972 | 14697 | 34928234 |
Anaesthetic complication | 21.50 | 14.89 | 10 | 13990 | 1110 | 34941821 |
Conjunctival ulcer | 21.47 | 14.89 | 5 | 13995 | 58 | 34942873 |
Intrapericardial thrombosis | 21.47 | 14.89 | 5 | 13995 | 58 | 34942873 |
Drug hypersensitivity | 21.47 | 14.89 | 76 | 13924 | 80453 | 34862478 |
Spontaneous haematoma | 21.22 | 14.89 | 8 | 13992 | 524 | 34942407 |
Headache | 20.89 | 14.89 | 30 | 13970 | 200605 | 34742326 |
Cardiac arrest | 20.88 | 14.89 | 85 | 13915 | 96074 | 34846857 |
Post embolisation syndrome | 20.74 | 14.89 | 5 | 13995 | 68 | 34942863 |
Catheter site haemorrhage | 20.10 | 14.89 | 12 | 13988 | 2212 | 34940719 |
Factor V inhibition | 20.07 | 14.89 | 6 | 13994 | 191 | 34942740 |
Procedural hypotension | 19.98 | 14.89 | 9 | 13991 | 927 | 34942004 |
Pyrexia | 19.38 | 14.89 | 211 | 13789 | 332802 | 34610129 |
Lymphopenia | 19.27 | 14.89 | 28 | 13972 | 16307 | 34926624 |
Tachycardia | 19.26 | 14.89 | 76 | 13924 | 84696 | 34858235 |
Post procedural haemorrhage | 19.25 | 14.89 | 20 | 13980 | 8269 | 34934662 |
Kidney transplant rejection | 19.07 | 14.89 | 19 | 13981 | 7478 | 34935453 |
Tryptase increased | 18.98 | 14.89 | 6 | 13994 | 231 | 34942700 |
Drug-induced liver injury | 18.84 | 14.89 | 38 | 13962 | 28794 | 34914137 |
Herpes simplex hepatitis | 18.80 | 14.89 | 5 | 13995 | 103 | 34942828 |
Cellulitis | 18.66 | 14.89 | 55 | 13945 | 52896 | 34890035 |
Viral uveitis | 18.52 | 14.89 | 4 | 13996 | 32 | 34942899 |
Disseminated intravascular coagulation | 18.30 | 14.89 | 32 | 13968 | 21784 | 34921147 |
Cardiac valve vegetation | 18.20 | 14.89 | 7 | 13993 | 484 | 34942447 |
Asthenia | 18.20 | 14.89 | 45 | 13955 | 245206 | 34697725 |
Coagulation factor VII level decreased | 18.07 | 14.89 | 5 | 13995 | 120 | 34942811 |
Dysbiosis | 17.76 | 14.89 | 7 | 13993 | 517 | 34942414 |
Systemic mastocytosis | 17.17 | 14.89 | 5 | 13995 | 145 | 34942786 |
Pruritus | 16.97 | 14.89 | 106 | 13894 | 141875 | 34801056 |
Haemodynamic instability | 16.97 | 14.89 | 20 | 13980 | 9503 | 34933428 |
Bacterial infection | 16.95 | 14.89 | 27 | 13973 | 17036 | 34925895 |
Eyelid oedema | 16.90 | 14.89 | 15 | 13985 | 5109 | 34937822 |
Blood creatine phosphokinase MB increased | 16.59 | 14.89 | 10 | 13990 | 1876 | 34941055 |
Appendicitis perforated | 16.48 | 14.89 | 10 | 13990 | 1898 | 34941033 |
Drug chemical incompatibility | 16.32 | 14.89 | 3 | 13997 | 9 | 34942922 |
Arteritis | 16.31 | 14.89 | 6 | 13994 | 367 | 34942564 |
Nodal rhythm | 16.29 | 14.89 | 9 | 13991 | 1434 | 34941497 |
Torsade de pointes | 16.03 | 14.89 | 17 | 13983 | 7192 | 34935739 |
Toxic shock syndrome | 15.78 | 14.89 | 6 | 13994 | 402 | 34942529 |
Procedural pain | 15.71 | 14.89 | 14 | 13986 | 4792 | 34938139 |
Shock haemorrhagic | 15.69 | 14.89 | 21 | 13979 | 11333 | 34931598 |
Arthrofibrosis | 15.60 | 14.89 | 4 | 13996 | 71 | 34942860 |
Staphylococcal bacteraemia | 15.47 | 14.89 | 18 | 13982 | 8434 | 34934497 |
Prothrombin level decreased | 15.45 | 14.89 | 8 | 13992 | 1120 | 34941811 |
Haemolytic anaemia | 15.43 | 14.89 | 20 | 13980 | 10459 | 34932472 |
Pseudomembranous colitis | 15.27 | 14.89 | 11 | 13989 | 2780 | 34940151 |
Laryngeal oedema | 15.15 | 14.89 | 12 | 13988 | 3496 | 34939435 |
Reperfusion injury | 15.05 | 14.89 | 4 | 13996 | 82 | 34942849 |
Acinetobacter infection | 14.94 | 14.89 | 8 | 13992 | 1199 | 34941732 |
Delayed recovery from anaesthesia | 14.90 | 14.89 | 7 | 13993 | 794 | 34942137 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Anaphylactic shock | 945.96 | 13.04 | 384 | 27324 | 35612 | 79681068 |
Anaphylactic reaction | 499.69 | 13.04 | 329 | 27379 | 83414 | 79633266 |
Hypotension | 246.10 | 13.04 | 499 | 27209 | 439818 | 79276862 |
Acute generalised exanthematous pustulosis | 236.85 | 13.04 | 117 | 27591 | 17137 | 79699543 |
Hypoprothrombinaemia | 208.42 | 13.04 | 49 | 27659 | 693 | 79715987 |
Kounis syndrome | 148.71 | 13.04 | 56 | 27652 | 4226 | 79712454 |
Bronchospasm | 136.78 | 13.04 | 93 | 27615 | 24766 | 79691914 |
Fatigue | 124.25 | 13.04 | 86 | 27622 | 929641 | 78787039 |
Urticaria | 118.96 | 13.04 | 223 | 27485 | 184978 | 79531702 |
Fear | 117.99 | 13.04 | 81 | 27627 | 21905 | 79694775 |
Erythema | 114.82 | 13.04 | 245 | 27463 | 223045 | 79493635 |
Vitamin K deficiency | 108.78 | 13.04 | 29 | 27679 | 699 | 79715981 |
Arthrodesis | 107.88 | 13.04 | 38 | 27670 | 2369 | 79714311 |
Renal injury | 104.40 | 13.04 | 68 | 27640 | 16859 | 79699821 |
Anhedonia | 99.68 | 13.04 | 63 | 27645 | 14835 | 79701845 |
Drug reaction with eosinophilia and systemic symptoms | 94.36 | 13.04 | 114 | 27594 | 64130 | 79652550 |
Lymphoid tissue hypoplasia | 92.83 | 13.04 | 27 | 27681 | 903 | 79715777 |
Type I hypersensitivity | 92.15 | 13.04 | 40 | 27668 | 4358 | 79712322 |
Thymus hypoplasia | 91.62 | 13.04 | 27 | 27681 | 946 | 79715734 |
Disseminated aspergillosis | 87.92 | 13.04 | 27 | 27681 | 1091 | 79715589 |
Drug-induced liver injury | 85.39 | 13.04 | 110 | 27598 | 66007 | 79650673 |
Unevaluable event | 82.23 | 13.04 | 99 | 27609 | 55486 | 79661194 |
Clostridium difficile colitis | 80.70 | 13.04 | 76 | 27632 | 32207 | 79684473 |
Blood pressure decreased | 79.62 | 13.04 | 132 | 27576 | 99334 | 79617346 |
Rash | 77.03 | 13.04 | 400 | 27308 | 577958 | 79138722 |
Renal failure | 76.40 | 13.04 | 196 | 27512 | 200772 | 79515908 |
Coagulopathy | 73.70 | 13.04 | 76 | 27632 | 35930 | 79680750 |
Clostridium test positive | 71.81 | 13.04 | 38 | 27670 | 6416 | 79710264 |
Cardiac arrest | 69.75 | 13.04 | 172 | 27536 | 171924 | 79544756 |
Allergy test negative | 67.90 | 13.04 | 17 | 27691 | 317 | 79716363 |
Tachycardia | 67.17 | 13.04 | 173 | 27535 | 177595 | 79539085 |
Post procedural complication | 65.19 | 13.04 | 59 | 27649 | 23770 | 79692910 |
Emotional distress | 63.76 | 13.04 | 74 | 27634 | 39895 | 79676785 |
Injury | 63.57 | 13.04 | 104 | 27604 | 77392 | 79639288 |
Headache | 58.97 | 13.04 | 85 | 27623 | 653687 | 79062993 |
Anaesthetic complication | 56.64 | 13.04 | 25 | 27683 | 2834 | 79713846 |
Toxic epidermal necrolysis | 54.17 | 13.04 | 72 | 27636 | 44509 | 79672171 |
Joint swelling | 51.50 | 13.04 | 18 | 27690 | 288628 | 79428052 |
Drug hypersensitivity | 50.75 | 13.04 | 222 | 27486 | 298694 | 79417986 |
Dizziness | 49.89 | 13.04 | 66 | 27642 | 526375 | 79190305 |
Multiple organ dysfunction syndrome | 49.56 | 13.04 | 121 | 27587 | 120125 | 79596555 |
Vitamin K decreased | 49.40 | 13.04 | 10 | 27698 | 66 | 79716614 |
Shock | 49.37 | 13.04 | 68 | 27640 | 43480 | 79673200 |
Eosinophilia | 48.71 | 13.04 | 69 | 27639 | 45276 | 79671404 |
Hepatic function abnormal | 48.07 | 13.04 | 89 | 27619 | 73018 | 79643662 |
Bradycardia | 47.19 | 13.04 | 128 | 27580 | 135429 | 79581251 |
Hypovitaminosis | 47.11 | 13.04 | 17 | 27691 | 1137 | 79715543 |
Product dose omission issue | 46.69 | 13.04 | 14 | 27694 | 247523 | 79469157 |
Weight increased | 46.64 | 13.04 | 19 | 27689 | 277367 | 79439313 |
Malaise | 45.81 | 13.04 | 62 | 27646 | 489807 | 79226873 |
Cytomegalovirus viraemia | 45.80 | 13.04 | 37 | 27671 | 12784 | 79703896 |
Disseminated intravascular coagulation | 45.27 | 13.04 | 59 | 27649 | 35783 | 79680897 |
Toxicity to various agents | 45.10 | 13.04 | 48 | 27660 | 421492 | 79295188 |
Brain herniation | 43.63 | 13.04 | 29 | 27679 | 7434 | 79709246 |
Weight decreased | 43.20 | 13.04 | 36 | 27672 | 355162 | 79361518 |
Angioedema | 43.17 | 13.04 | 87 | 27621 | 75948 | 79640732 |
Rash maculo-papular | 42.96 | 13.04 | 73 | 27635 | 56005 | 79660675 |
Death | 42.40 | 13.04 | 83 | 27625 | 566431 | 79150249 |
Linear IgA disease | 42.25 | 13.04 | 21 | 27687 | 3111 | 79713569 |
Post procedural hypotension | 42.09 | 13.04 | 9 | 27699 | 80 | 79716600 |
Alopecia | 42.00 | 13.04 | 14 | 27694 | 231341 | 79485339 |
Pseudomembranous colitis | 41.74 | 13.04 | 25 | 27683 | 5349 | 79711331 |
Drug intolerance | 41.39 | 13.04 | 20 | 27688 | 264099 | 79452581 |
Post procedural haematoma | 40.92 | 13.04 | 19 | 27689 | 2423 | 79714257 |
Tubulointerstitial nephritis | 40.80 | 13.04 | 58 | 27650 | 38177 | 79678503 |
Sinusitis | 40.80 | 13.04 | 9 | 27699 | 195492 | 79521188 |
Hyperthermia malignant | 40.67 | 13.04 | 20 | 27688 | 2897 | 79713783 |
Peripheral swelling | 39.90 | 13.04 | 22 | 27686 | 269595 | 79447085 |
Renal impairment | 39.80 | 13.04 | 133 | 27575 | 157650 | 79559030 |
Vascular purpura | 39.53 | 13.04 | 20 | 27688 | 3078 | 79713602 |
Arthralgia | 38.43 | 13.04 | 89 | 27619 | 571714 | 79144966 |
Face oedema | 38.18 | 13.04 | 48 | 27660 | 28088 | 79688592 |
Device related infection | 36.56 | 13.04 | 52 | 27656 | 34242 | 79682438 |
Diarrhoea | 36.38 | 13.04 | 170 | 27538 | 880319 | 78836361 |
Haemolytic anaemia | 35.35 | 13.04 | 37 | 27671 | 17783 | 79698897 |
Staphylococcal bacteraemia | 34.89 | 13.04 | 31 | 27677 | 12187 | 79704493 |
Maternal exposure during delivery | 34.06 | 13.04 | 14 | 27694 | 1332 | 79715348 |
Pseudomonal sepsis | 33.72 | 13.04 | 23 | 27685 | 6151 | 79710529 |
Premature delivery | 33.39 | 13.04 | 41 | 27667 | 23426 | 79693254 |
Asthenia | 33.28 | 13.04 | 81 | 27627 | 511608 | 79205072 |
Ventricular tachycardia | 32.66 | 13.04 | 55 | 27653 | 41880 | 79674800 |
Pain in extremity | 32.20 | 13.04 | 48 | 27660 | 364490 | 79352190 |
Eyelid oedema | 31.88 | 13.04 | 31 | 27677 | 13656 | 79703024 |
Toxic skin eruption | 31.80 | 13.04 | 39 | 27669 | 22254 | 79694426 |
Post procedural haemorrhage | 31.77 | 13.04 | 31 | 27677 | 13713 | 79702967 |
Nasopharyngitis | 31.76 | 13.04 | 25 | 27683 | 253856 | 79462824 |
Procedural hypotension | 31.62 | 13.04 | 15 | 27693 | 2008 | 79714672 |
Injection site pain | 31.45 | 13.04 | 4 | 27704 | 129834 | 79586846 |
Cholestasis | 31.23 | 13.04 | 61 | 27647 | 52048 | 79664632 |
Haemodynamic instability | 30.81 | 13.04 | 34 | 27674 | 17348 | 79699332 |
Recurrence of neuromuscular blockade | 30.68 | 13.04 | 9 | 27699 | 310 | 79716370 |
Shock haemorrhagic | 30.09 | 13.04 | 36 | 27672 | 20024 | 79696656 |
Shoulder arthroplasty | 30.08 | 13.04 | 17 | 27691 | 3265 | 79713415 |
Intentional product use issue | 29.79 | 13.04 | 8 | 27700 | 152104 | 79564576 |
Pulseless electrical activity | 29.17 | 13.04 | 30 | 27678 | 14130 | 79702550 |
Arthrofibrosis | 29.02 | 13.04 | 7 | 27701 | 111 | 79716569 |
Heparin-induced thrombocytopenia | 28.52 | 13.04 | 25 | 27683 | 9657 | 79707023 |
Strongyloidiasis | 27.37 | 13.04 | 17 | 27691 | 3881 | 79712799 |
Infusion related reaction | 27.16 | 13.04 | 24 | 27684 | 230213 | 79486467 |
Pathogen resistance | 27.07 | 13.04 | 29 | 27679 | 14313 | 79702367 |
Drug eruption | 27.02 | 13.04 | 52 | 27656 | 43883 | 79672797 |
Limb operation | 26.77 | 13.04 | 16 | 27692 | 3410 | 79713270 |
Systemic lupus erythematosus | 26.47 | 13.04 | 5 | 27703 | 121144 | 79595536 |
Septic shock | 26.21 | 13.04 | 98 | 27610 | 122703 | 79593977 |
Purpura senile | 26.19 | 13.04 | 9 | 27699 | 521 | 79716159 |
Tarsal tunnel syndrome | 26.09 | 13.04 | 9 | 27699 | 527 | 79716153 |
Pyrexia | 25.88 | 13.04 | 354 | 27354 | 678355 | 79038325 |
Conjunctival ulcer | 25.84 | 13.04 | 6 | 27702 | 80 | 79716600 |
Pericarditis fungal | 25.79 | 13.04 | 7 | 27701 | 181 | 79716499 |
Acute hepatic failure | 25.47 | 13.04 | 41 | 27667 | 30072 | 79686608 |
Gastritis fungal | 25.43 | 13.04 | 7 | 27701 | 191 | 79716489 |
Dysbiosis | 25.25 | 13.04 | 11 | 27697 | 1208 | 79715472 |
Insomnia | 25.00 | 13.04 | 29 | 27679 | 245141 | 79471539 |
Metabolic acidosis | 24.87 | 13.04 | 74 | 27634 | 82455 | 79634225 |
Gastrointestinal disorder | 24.74 | 13.04 | 6 | 27702 | 122199 | 79594481 |
Hepatic enzyme abnormal | 24.69 | 13.04 | 21 | 27687 | 7789 | 79708891 |
Rash morbilliform | 24.66 | 13.04 | 19 | 27689 | 6131 | 79710549 |
Tryptase increased | 24.35 | 13.04 | 9 | 27699 | 644 | 79716036 |
Tonic clonic movements | 24.25 | 13.04 | 13 | 27695 | 2251 | 79714429 |
Laryngeal oedema | 23.96 | 13.04 | 21 | 27687 | 8108 | 79708572 |
Respiratory failure | 23.86 | 13.04 | 125 | 27583 | 180786 | 79535894 |
Adrenal suppression | 23.80 | 13.04 | 11 | 27697 | 1388 | 79715292 |
Contusion | 23.70 | 13.04 | 11 | 27697 | 148765 | 79567915 |
Pruritus | 23.69 | 13.04 | 225 | 27483 | 394423 | 79322257 |
Off label use | 23.56 | 13.04 | 202 | 27506 | 907013 | 78809667 |
Muscle spasms | 23.41 | 13.04 | 16 | 27692 | 174714 | 79541966 |
Cellulitis | 23.25 | 13.04 | 87 | 27621 | 108973 | 79607707 |
Necrotising oesophagitis | 22.92 | 13.04 | 10 | 27698 | 1103 | 79715577 |
Intentional product misuse | 22.88 | 13.04 | 3 | 27705 | 95162 | 79621518 |
Mobility decreased | 22.86 | 13.04 | 7 | 27701 | 122168 | 79594512 |
Arterial angioplasty | 22.85 | 13.04 | 5 | 27703 | 50 | 79716630 |
Musculoskeletal pain | 22.84 | 13.04 | 4 | 27704 | 102350 | 79614330 |
Embolic stroke | 22.63 | 13.04 | 20 | 27688 | 7806 | 79708874 |
Brain oedema | 22.20 | 13.04 | 35 | 27673 | 25228 | 79691452 |
Intrapericardial thrombosis | 22.18 | 13.04 | 5 | 27703 | 58 | 79716622 |
Clostridium difficile infection | 22.06 | 13.04 | 47 | 27661 | 42638 | 79674042 |
Acinetobacter infection | 21.78 | 13.04 | 13 | 27695 | 2764 | 79713916 |
Airway peak pressure increased | 21.57 | 13.04 | 7 | 27701 | 339 | 79716341 |
Lower respiratory tract infection | 21.46 | 13.04 | 9 | 27699 | 129211 | 79587469 |
Pyomyositis | 21.07 | 13.04 | 8 | 27700 | 617 | 79716063 |
Oropharyngeal pain | 20.94 | 13.04 | 6 | 27702 | 109347 | 79607333 |
Catheter site haemorrhage | 20.94 | 13.04 | 16 | 27692 | 5101 | 79711579 |
Musculoskeletal stiffness | 20.93 | 13.04 | 18 | 27690 | 174990 | 79541690 |
Meningitis fungal | 20.88 | 13.04 | 6 | 27702 | 192 | 79716488 |
Fall | 20.75 | 13.04 | 93 | 27615 | 487536 | 79229144 |
Manipulation | 20.75 | 13.04 | 5 | 27703 | 79 | 79716601 |
Therapeutic product effect decreased | 20.66 | 13.04 | 16 | 27692 | 163847 | 79552833 |
Thrombotic microangiopathy | 20.64 | 13.04 | 30 | 27678 | 20139 | 79696541 |
Post embolisation syndrome | 20.46 | 13.04 | 5 | 27703 | 84 | 79716596 |
Skin graft | 20.41 | 13.04 | 9 | 27699 | 1018 | 79715662 |
Contraindicated product administered | 20.35 | 13.04 | 15 | 27693 | 157523 | 79559157 |
Circulatory collapse | 20.07 | 13.04 | 42 | 27666 | 37626 | 79679054 |
Asthma | 20.00 | 13.04 | 11 | 27697 | 135084 | 79581596 |
Macular oedema | 19.98 | 13.04 | 16 | 27692 | 5458 | 79711222 |
Procedural haemorrhage | 19.88 | 13.04 | 15 | 27693 | 4691 | 79711989 |
Myoclonus | 19.86 | 13.04 | 35 | 27673 | 27625 | 79689055 |
Kidney transplant rejection | 19.84 | 13.04 | 21 | 27687 | 10225 | 79706455 |
Aspartate aminotransferase increased | 19.82 | 13.04 | 98 | 27610 | 138543 | 79578137 |
Electrocardiogram ST segment elevation | 19.52 | 13.04 | 19 | 27689 | 8378 | 79708302 |
Hepatitis cholestatic | 19.38 | 13.04 | 24 | 27684 | 13828 | 79702852 |
Cholestatic liver injury | 19.23 | 13.04 | 15 | 27693 | 4926 | 79711754 |
Bacterial infection | 19.21 | 13.04 | 37 | 27671 | 31243 | 79685437 |
Coagulation factor X level decreased | 19.19 | 13.04 | 5 | 27703 | 110 | 79716570 |
Blood creatine phosphokinase MB increased | 19.08 | 13.04 | 12 | 27696 | 2799 | 79713881 |
Delayed recovery from anaesthesia | 19.03 | 13.04 | 10 | 27698 | 1663 | 79715017 |
Postoperative wound infection | 19.02 | 13.04 | 23 | 27685 | 12938 | 79703742 |
Endotracheal intubation complication | 18.95 | 13.04 | 8 | 27700 | 814 | 79715866 |
Generalised tonic-clonic seizure | 18.95 | 13.04 | 45 | 27663 | 43865 | 79672815 |
Treatment failure | 18.66 | 13.04 | 19 | 27689 | 170467 | 79546213 |
Lymphopenia | 18.59 | 13.04 | 36 | 27672 | 30521 | 79686159 |
Disease progression | 18.58 | 13.04 | 22 | 27686 | 184340 | 79532340 |
Hypoxia | 18.49 | 13.04 | 78 | 27630 | 103165 | 79613515 |
Diabetes insipidus | 18.46 | 13.04 | 15 | 27693 | 5222 | 79711458 |
Herpes simplex hepatitis | 18.46 | 13.04 | 7 | 27701 | 538 | 79716142 |
Migraine | 18.30 | 13.04 | 4 | 27704 | 87489 | 79629191 |
Memory impairment | 18.20 | 13.04 | 8 | 27700 | 111726 | 79604954 |
Jaundice cholestatic | 18.17 | 13.04 | 21 | 27687 | 11263 | 79705417 |
Encephalopathy | 18.04 | 13.04 | 58 | 27650 | 67339 | 79649341 |
Hypoventilation | 18.03 | 13.04 | 17 | 27691 | 7207 | 79709473 |
Arthropathy | 17.99 | 13.04 | 21 | 27687 | 177090 | 79539590 |
Spinal cord haematoma | 17.95 | 13.04 | 6 | 27702 | 319 | 79716361 |
COVID-19 | 17.92 | 13.04 | 17 | 27691 | 157657 | 79559023 |
Eye abscess | 17.65 | 13.04 | 6 | 27702 | 336 | 79716344 |
Mixed liver injury | 17.34 | 13.04 | 17 | 27691 | 7561 | 79709119 |
Resorption bone increased | 17.31 | 13.04 | 9 | 27699 | 1466 | 79715214 |
Loss of personal independence in daily activities | 17.26 | 13.04 | 7 | 27701 | 102573 | 79614107 |
Implant site haematoma | 17.22 | 13.04 | 5 | 27703 | 166 | 79716514 |
Fear of death | 17.07 | 13.04 | 9 | 27699 | 1507 | 79715173 |
Factor V inhibition | 17.02 | 13.04 | 6 | 27702 | 375 | 79716305 |
Inappropriate schedule of product administration | 16.90 | 13.04 | 13 | 27695 | 133615 | 79583065 |
Delayed graft function | 16.67 | 13.04 | 12 | 27696 | 3495 | 79713185 |
Acute kidney injury | 16.64 | 13.04 | 263 | 27445 | 519141 | 79197539 |
Procedural complication | 16.60 | 13.04 | 17 | 27691 | 7966 | 79708714 |
Therapeutic product effect incomplete | 16.42 | 13.04 | 15 | 27693 | 141630 | 79575050 |
Staphylococcal infection | 16.37 | 13.04 | 51 | 27657 | 58244 | 79658436 |
Mycobacterial peritonitis | 16.27 | 13.04 | 4 | 27704 | 69 | 79716611 |
Balance disorder | 16.23 | 13.04 | 7 | 27701 | 98850 | 79617830 |
Discomfort | 16.17 | 13.04 | 12 | 27696 | 125605 | 79591075 |
Cutaneous vasculitis | 16.13 | 13.04 | 17 | 27691 | 8235 | 79708445 |
Feeling abnormal | 16.04 | 13.04 | 19 | 27689 | 159180 | 79557500 |
Lip oedema | 16.03 | 13.04 | 15 | 27693 | 6301 | 79710379 |
General physical health deterioration | 16.01 | 13.04 | 46 | 27662 | 275192 | 79441488 |
Anaphylactoid reaction | 15.97 | 13.04 | 14 | 27694 | 5408 | 79711272 |
Sleep disorder | 15.86 | 13.04 | 5 | 27703 | 85672 | 79631008 |
Toxic shock syndrome | 15.75 | 13.04 | 8 | 27700 | 1241 | 79715439 |
Coagulation factor VII level decreased | 15.72 | 13.04 | 5 | 27703 | 227 | 79716453 |
Vestibular disorder | 15.47 | 13.04 | 10 | 27698 | 2445 | 79714235 |
Alanine aminotransferase increased | 15.40 | 13.04 | 103 | 27605 | 162467 | 79554213 |
Hypothermia | 15.33 | 13.04 | 28 | 27680 | 22718 | 79693962 |
Dyspnoea | 15.29 | 13.04 | 208 | 27500 | 856817 | 78859863 |
Jaundice | 15.28 | 13.04 | 47 | 27661 | 53302 | 79663378 |
Psoriasis | 15.26 | 13.04 | 6 | 27702 | 89581 | 79627099 |
Irregular breathing | 15.22 | 13.04 | 6 | 27702 | 512 | 79716168 |
Swelling | 15.11 | 13.04 | 33 | 27675 | 216678 | 79500002 |
Fungal infection | 15.09 | 13.04 | 40 | 27668 | 41708 | 79674972 |
Wound | 15.08 | 13.04 | 11 | 27697 | 116168 | 79600512 |
Cardiac valve vegetation | 14.93 | 13.04 | 7 | 27701 | 912 | 79715768 |
Myalgia | 14.91 | 13.04 | 26 | 27682 | 185615 | 79531065 |
Oxygen saturation decreased | 14.88 | 13.04 | 86 | 27622 | 128961 | 79587719 |
Hypersensitivity vasculitis | 14.83 | 13.04 | 15 | 27693 | 6928 | 79709752 |
Vertigo | 14.77 | 13.04 | 3 | 27705 | 69079 | 79647601 |
Spontaneous haematoma | 14.77 | 13.04 | 8 | 27700 | 1414 | 79715266 |
Influenza | 14.69 | 13.04 | 14 | 27694 | 129592 | 79587088 |
Arthritis bacterial | 14.66 | 13.04 | 17 | 27691 | 9149 | 79707531 |
Cataract subcapsular | 14.63 | 13.04 | 7 | 27701 | 954 | 79715726 |
Torsade de pointes | 14.60 | 13.04 | 25 | 27683 | 19287 | 79697393 |
Syncope | 14.53 | 13.04 | 25 | 27683 | 179424 | 79537256 |
Laryngeal dyspnoea | 14.44 | 13.04 | 5 | 27703 | 296 | 79716384 |
Cough | 14.39 | 13.04 | 72 | 27636 | 366717 | 79349963 |
Drug chemical incompatibility | 14.23 | 13.04 | 4 | 27704 | 118 | 79716562 |
Jaundice acholuric | 14.20 | 13.04 | 4 | 27704 | 119 | 79716561 |
Exposure during pregnancy | 14.10 | 13.04 | 71 | 27637 | 101061 | 79615619 |
Propionibacterium infection | 14.04 | 13.04 | 5 | 27703 | 322 | 79716358 |
Blood creatinine increased | 13.95 | 13.04 | 97 | 27611 | 154960 | 79561720 |
Systemic mastocytosis | 13.89 | 13.04 | 5 | 27703 | 332 | 79716348 |
Altered state of consciousness | 13.87 | 13.04 | 40 | 27668 | 43782 | 79672898 |
Decorticate posture | 13.82 | 13.04 | 5 | 27703 | 337 | 79716343 |
Procedural pain | 13.80 | 13.04 | 27 | 27681 | 23057 | 79693623 |
Cerebral infarction | 13.80 | 13.04 | 41 | 27667 | 45635 | 79671045 |
Eosinophilic pneumonia acute | 13.75 | 13.04 | 7 | 27701 | 1091 | 79715589 |
Injection site erythema | 13.72 | 13.04 | 5 | 27703 | 78192 | 79638488 |
Respiratory distress | 13.66 | 13.04 | 48 | 27660 | 58291 | 79658389 |
International normalised ratio increased | 13.64 | 13.04 | 62 | 27646 | 84659 | 79632021 |
Stevens-Johnson syndrome | 13.63 | 13.04 | 37 | 27671 | 39129 | 79677551 |
Hypoaesthesia | 13.61 | 13.04 | 26 | 27682 | 179326 | 79537354 |
Endotracheal intubation | 13.58 | 13.04 | 12 | 27696 | 4685 | 79711995 |
Back pain | 13.54 | 13.04 | 57 | 27651 | 304123 | 79412557 |
Hypokalaemia | 13.49 | 13.04 | 91 | 27617 | 143949 | 79572731 |
Status epilepticus | 13.43 | 13.04 | 28 | 27680 | 25013 | 79691667 |
Fibromyalgia | 13.34 | 13.04 | 3 | 27705 | 64337 | 79652343 |
Gait disturbance | 13.34 | 13.04 | 33 | 27675 | 207473 | 79509207 |
Blood pressure increased | 13.28 | 13.04 | 34 | 27674 | 211326 | 79505354 |
Serotonin syndrome | 13.21 | 13.04 | 40 | 27668 | 44987 | 79671693 |
Stupor | 13.15 | 13.04 | 14 | 27694 | 6858 | 79709822 |
Eosinophilic myocarditis | 13.04 | 13.04 | 7 | 27701 | 1215 | 79715465 |
None
Source | Code | Description |
---|---|---|
ATC | J01DB04 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS First-generation cephalosporins |
FDA CS | M0003827 | Cephalosporins |
FDA EPC | N0000175488 | Cephalosporin Antibacterial |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Bacterial septicemia | indication | 10001005 | DOID:0040085 |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Staphylococcal pneumonia | indication | 22754005 | |
Pneumonia due to Streptococcus | indication | 34020007 | |
Lower respiratory tract infection | indication | 50417007 | |
Bacterial pneumonia | indication | 53084003 | DOID:874 |
Cholangitis | indication | 82403002 | DOID:9446 |
Infection of bone | indication | 111253001 | |
Bacterial endocarditis | indication | 301183007 | |
Bacterial urinary infection | indication | 312124009 | |
Infectious disorder of joint | indication | 363162000 | |
Infection of biliary tract | indication | 846685008 | |
Prevention of Perioperative Infection | indication | ||
Genitourinary Tract Infections | indication | ||
Prevention of Bacterial Endocarditis | off-label use | ||
Acute nephropathy | contraindication | 58574008 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Factor II deficiency | contraindication | 73975000 | |
Pseudomembranous enterocolitis | contraindication | 397683000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.22 | acidic |
pKa2 | 12.21 | acidic |
pKa3 | 1.52 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
EQ 1GM BASE/VIAL | CEFAZOLIN AND DEXTROSE | B BRAUN | N050779 | July 27, 2000 | RX | INJECTABLE | INJECTION | Nov. 23, 2023 | NEW PATIENT POPULATION |
EQ 2GM BASE/VIAL | CEFAZOLIN AND DEXTROSE | B BRAUN | N050779 | Jan. 13, 2012 | RX | INJECTABLE | INJECTION | Nov. 23, 2023 | NEW PATIENT POPULATION |
EQ 500MG BASE/VIAL | CEFAZOLIN AND DEXTROSE | B BRAUN | N050779 | July 27, 2000 | DISCN | INJECTABLE | INJECTION | Nov. 23, 2023 | NEW PATIENT POPULATION |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
Penicillin-binding protein 1A | Enzyme | WOMBAT-PK |
ID | Source |
---|---|
4019659 | VUID |
N0000147751 | NUI |
D00905 | KEGG_DRUG |
27164-46-1 | SECONDARY_CAS_RN |
203171 | RXNORM |
C0007546 | UMLSCUI |
CHEBI:474053 | CHEBI |
CHEMBL1435 | ChEMBL_ID |
CHEMBL1200523 | ChEMBL_ID |
D002437 | MESH_DESCRIPTOR_UI |
DB01327 | DRUGBANK_ID |
10935 | IUPHAR_LIGAND_ID |
2991 | INN_ID |
IHS69L0Y4T | UNII |
33255 | PUBCHEM_CID |
35509 | MMSL |
4371 | MMSL |
948 | MMSL |
d00007 | MMSL |
387470007 | SNOMEDCT_US |
80972005 | SNOMEDCT_US |
81088002 | SNOMEDCT_US |
4017460 | VANDF |
4019659 | VANDF |
002720 | NDDF |
004841 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Cefazolin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9139 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 2 g | INTRAVENOUS | NDA | 28 sections |
Cefazolin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9140 | INJECTION, POWDER, FOR SOLUTION | 3 g | INTRAVENOUS | NDA | 28 sections |
Cefazolin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9261 | INJECTION, POWDER, FOR SOLUTION | 10 g | INTRAVENOUS | ANDA | 23 sections |
Cefazolin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9262 | INJECTION, POWDER, FOR SOLUTION | 330 mg | INTRAMUSCULAR | ANDA | 24 sections |
Cefazolin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9262 | INJECTION, POWDER, FOR SOLUTION | 330 mg | INTRAMUSCULAR | ANDA | 24 sections |
Cefazolin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9665 | INJECTION, POWDER, FOR SOLUTION | 20 g | INTRAVENOUS | ANDA | 23 sections |
Cefazolin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9923 | INJECTION, POWDER, FOR SOLUTION | 225 mg | INTRAMUSCULAR | ANDA | 24 sections |
Cefazolin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9923 | INJECTION, POWDER, FOR SOLUTION | 225 mg | INTRAMUSCULAR | ANDA | 24 sections |
Cefazolin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9924 | INJECTION, POWDER, FOR SOLUTION | 330 mg | INTRAMUSCULAR | ANDA | 24 sections |
Cefazolin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9924 | INJECTION, POWDER, FOR SOLUTION | 330 mg | INTRAMUSCULAR | ANDA | 24 sections |
Cefazolin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9983 | INJECTION, POWDER, FOR SOLUTION | 10 g | INTRAVENOUS | ANDA | 23 sections |
Cefazolin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3103 | SOLUTION | 1 g | INTRAVENOUS | NDA | 27 sections |
Cefazolin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3105 | SOLUTION | 2 g | INTRAVENOUS | NDA | 27 sections |
Cefazolin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-3503 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | ANDA | 24 sections |
Cefazolin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-3503 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | ANDA | 24 sections |
Cefazolin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-3503 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | ANDA | 24 sections |
Cefazolin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-3508 | INJECTION, SOLUTION | 2 g | INTRAVENOUS | NDA | 26 sections |
Cefazolin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-3508 | INJECTION, SOLUTION | 2 g | INTRAVENOUS | NDA | 26 sections |
CEFAZOLIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9833 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAMUSCULAR | ANDA | 17 sections |
CEFAZOLIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9833 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAMUSCULAR | ANDA | 17 sections |
CEFAZOLIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9833 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAMUSCULAR | ANDA | 17 sections |
CEFAZOLIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9834 | INJECTION, POWDER, FOR SOLUTION | 330 mg | INTRAMUSCULAR | ANDA | 10 sections |
CEFAZOLIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9834 | INJECTION, POWDER, FOR SOLUTION | 330 mg | INTRAMUSCULAR | ANDA | 10 sections |
CEFAZOLIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9834 | INJECTION, POWDER, FOR SOLUTION | 330 mg | INTRAMUSCULAR | ANDA | 10 sections |
CEFAZOLIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9835 | INJECTION, POWDER, FOR SOLUTION | 225 mg | INTRAMUSCULAR | ANDA | 11 sections |
CEFAZOLIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9835 | INJECTION, POWDER, FOR SOLUTION | 225 mg | INTRAMUSCULAR | ANDA | 11 sections |
CEFAZOLIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9835 | INJECTION, POWDER, FOR SOLUTION | 225 mg | INTRAMUSCULAR | ANDA | 11 sections |
Cefazolin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2585 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 23 sections |
Cefazolin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3450 | INJECTION, POWDER, FOR SOLUTION | 500 mg | INTRAMUSCULAR | ANDA | 21 sections |
Cefazolin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3451 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAMUSCULAR | ANDA | 21 sections |