insulin lispro 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5002 133107-64-9

Description:

MoleculeDescription

Synonyms:

  • insulin lispro BS
  • lyumjev
  • insulin lispro protamine recombinant
  • insulin lispro protamine
  • insulin lispro
  • humalog
  • insulin lispro recombinant
  • humalog lispro
Insulin that has been modified so that the B-chain contains a LYSINE at position 28 instead of a PROLINE and a PROLINE at position 29 instead of a LYSINE. It is used to manage BLOOD GLUCOSE levels in patients with TYPE 2 DIABETES.
  • Molecular weight: 5807.63
  • Formula: C257H383N65O77S6
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 2299.07
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
40 U P
40 U P
40 U P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
April 30, 1996 EMA Eli Lilly Nederland B.V.
June 14, 1996 FDA LILLY
March 25, 2020 PMDA Eli Lilly Japan K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood glucose increased 2777.74 11.05 1380 53423 82376 63351843
Hypoglycaemia 1402.19 11.05 784 54019 59281 63374938
Blood glucose decreased 653.11 11.05 332 54471 20620 63413599
Diabetic ketoacidosis 639.40 11.05 325 54478 20180 63414039
Diabetes mellitus inadequate control 531.38 11.05 260 54543 14866 63419353
Hyperglycaemia 401.72 11.05 314 54489 41553 63392666
Glycosylated haemoglobin increased 384.93 11.05 196 54607 12202 63422017
Blood glucose abnormal 377.53 11.05 168 54635 7724 63426495
Blood glucose fluctuation 297.15 11.05 121 54682 4455 63429764
Incorrect dose administered 277.70 11.05 299 54504 59669 63374550
Eye haemorrhage 234.11 11.05 124 54679 8372 63425847
Wrong product administered 207.98 11.05 103 54700 6038 63428181
Accidental underdose 164.64 11.05 50 54753 753 63433466
Diabetic retinopathy 156.12 11.05 63 54740 2264 63431955
Hypoglycaemic coma 143.30 11.05 61 54742 2514 63431705
Systemic lupus erythematosus 136.08 11.05 12 54791 208906 63225313
Glossodynia 136.00 11.05 4 54799 178872 63255347
Ketoacidosis 132.34 11.05 68 54735 4310 63429909
Contraindicated product administered 118.94 11.05 22 54781 217626 63216593
Abdominal discomfort 112.48 11.05 69 54734 320816 63113403
Drug intolerance 111.53 11.05 64 54739 308597 63125622
Eye discharge 106.55 11.05 66 54737 5997 63428222
Underdose 104.99 11.05 124 54679 27332 63406887
Treatment failure 104.80 11.05 22 54781 199021 63235198
Gangrene 100.93 11.05 64 54739 6059 63428160
Hypoglycaemic unconsciousness 96.25 11.05 33 54770 744 63433475
Alopecia 96.00 11.05 90 54713 337446 63096773
Blindness 94.80 11.05 105 54698 21594 63412625
Insulin resistance 92.30 11.05 33 54770 845 63433374
Diabetic retinal oedema 91.50 11.05 26 54777 306 63433913
Arterial occlusive disease 90.13 11.05 59 54744 5899 63428320
Product storage error 90.05 11.05 86 54717 14870 63419349
Joint swelling 85.62 11.05 94 54709 327572 63106647
Acute kidney injury 85.02 11.05 450 54353 262965 63171254
Therapeutic product effect decreased 83.77 11.05 31 54772 193156 63241063
Cardiac failure congestive 83.11 11.05 220 54583 92213 63342006
Infusion related reaction 82.97 11.05 55 54748 245466 63188753
Rash 82.80 11.05 231 54572 560640 62873579
Pericarditis 81.86 11.05 9 54794 131570 63302649
Synovitis 81.03 11.05 30 54773 186888 63247331
Cataract 80.26 11.05 162 54641 56891 63377328
Hepatic enzyme increased 75.86 11.05 40 54763 202288 63231931
Discomfort 75.75 11.05 25 54778 167349 63266870
Arthropathy 74.84 11.05 56 54747 234736 63199483
Hypoglycaemia unawareness 74.65 11.05 18 54785 104 63434115
Hypoglycaemic seizure 73.26 11.05 24 54779 468 63433751
Off label use 71.92 11.05 319 54484 674143 62760076
Infective pulmonary exacerbation of cystic fibrosis 71.52 11.05 60 54743 8757 63425462
Product dispensing error 71.22 11.05 64 54739 10241 63423978
Arthralgia 68.50 11.05 257 54546 569453 62864766
Visual acuity reduced 66.52 11.05 88 54715 21738 63412481
Product complaint 64.80 11.05 67 54736 12742 63421477
Intercepted product selection error 63.87 11.05 12 54791 13 63434206
Nasal obstruction 61.49 11.05 30 54773 1701 63432518
Increased insulin requirement 60.09 11.05 14 54789 68 63434151
Helicobacter infection 58.59 11.05 6 54797 92779 63341440
Diabetic neuropathy 56.92 11.05 38 54765 3926 63430293
Visual impairment 56.62 11.05 181 54622 84265 63349954
Swelling 55.76 11.05 95 54708 275283 63158936
Angina pectoris 55.55 11.05 96 54707 29982 63404237
Renal failure 53.31 11.05 222 54581 117430 63316789
Multi-organ disorder 53.10 11.05 26 54777 1486 63432733
Lower respiratory tract infection 52.84 11.05 24 54779 132283 63301936
Throat clearing 52.04 11.05 30 54773 2389 63431830
Product administration error 51.57 11.05 79 54724 22318 63411901
Toxicity to various agents 51.25 11.05 84 54719 247166 63187053
Intercepted product dispensing error 50.82 11.05 13 54790 99 63434120
Loss of consciousness 50.51 11.05 219 54584 117902 63316317
Eye pruritus 50.43 11.05 71 54732 18600 63415619
Injury associated with device 49.90 11.05 34 54769 3632 63430587
Product dose omission issue 49.47 11.05 359 54444 233954 63200265
Musculoskeletal stiffness 49.23 11.05 52 54751 184566 63249653
Anti-insulin antibody increased 48.00 11.05 11 54792 49 63434170
Cerebrovascular accident 46.73 11.05 201 54602 107823 63326396
Folliculitis 45.85 11.05 4 54799 70313 63363906
Product use issue 44.69 11.05 76 54727 220444 63213775
Irritable bowel syndrome 43.57 11.05 9 54794 82403 63351816
Anti-insulin antibody positive 42.09 11.05 11 54792 92 63434127
Pre-eclampsia 39.55 11.05 44 54759 9089 63425130
Hypoglycaemia neonatal 37.98 11.05 18 54785 957 63433262
Diabetes mellitus 36.83 11.05 119 54684 55691 63378528
Diabetic foot 36.72 11.05 20 54783 1427 63432792
Anti-insulin antibody 36.01 11.05 8 54795 30 63434189
Shock hypoglycaemic 35.40 11.05 10 54793 115 63434104
Type 1 diabetes mellitus 35.39 11.05 28 54775 3762 63430457
Drug ineffective 35.07 11.05 664 54139 1044101 62390118
Pain 34.91 11.05 441 54362 740187 62694032
Stomatitis 34.86 11.05 41 54762 138684 63295535
Exposure during pregnancy 34.35 11.05 241 54562 155306 63278913
Transcription medication error 33.74 11.05 11 54792 211 63434008
Blister 33.01 11.05 38 54765 129776 63304443
Completed suicide 32.55 11.05 47 54756 145626 63288593
Large for dates baby 32.14 11.05 13 54790 470 63433749
Neurologic neglect syndrome 31.83 11.05 23 54780 2698 63431521
Carotid artery thrombosis 31.28 11.05 23 54780 2771 63431448
Hyperkalaemia 30.86 11.05 110 54693 54093 63380126
Transient tachypnoea of the newborn 30.51 11.05 9 54794 122 63434097
Rheumatoid arthritis 29.43 11.05 116 54687 253703 63180516
Wound 28.91 11.05 61 54742 163202 63271017
Wrong technique in product usage process 28.50 11.05 118 54685 62222 63371997
Pancreatic carcinoma 28.41 11.05 34 54769 7594 63426625
Mobility decreased 28.15 11.05 38 54765 121121 63313098
Ill-defined disorder 28.00 11.05 18 54785 81737 63352482
Ventricular septal defect 27.93 11.05 26 54777 4352 63429867
Keratitis 27.16 11.05 23 54780 3399 63430820
Diabetic complication 27.07 11.05 14 54789 899 63433320
Epileptic encephalopathy 26.90 11.05 10 54793 287 63433932
Intentional product use issue 26.89 11.05 43 54760 127849 63306370
Pseudomonal bacteraemia 26.79 11.05 17 54786 1611 63432608
Chronic kidney disease 26.59 11.05 93 54710 45305 63388914
Thyroid disorder 26.19 11.05 47 54756 15115 63419104
Rhonchi 26.16 11.05 20 54783 2556 63431663
Diabetic nephropathy 25.98 11.05 16 54787 1438 63432781
Acute respiratory failure 25.97 11.05 77 54726 34408 63399811
Hip arthroplasty 25.60 11.05 5 54798 47641 63386578
Sopor 25.47 11.05 58 54745 22106 63412113
Small for dates baby 25.34 11.05 23 54780 3728 63430491
Treatment noncompliance 25.00 11.05 80 54723 37245 63396974
Neuropathic arthropathy 24.38 11.05 9 54794 253 63433966
Malignant neoplasm progression 24.36 11.05 21 54782 82100 63352119
Urinary tract obstruction 24.33 11.05 18 54785 2190 63432029
Dopamine transporter scintigraphy abnormal 24.21 11.05 7 54796 88 63434131
Croup infectious 24.11 11.05 11 54792 536 63433683
Cystic fibrosis 23.83 11.05 21 54782 3275 63430944
Expired product administered 23.76 11.05 28 54775 6153 63428066
Device operational issue 23.61 11.05 9 54794 277 63433942
Personality disorder 23.47 11.05 27 54776 5784 63428435
Premature delivery 23.17 11.05 68 54735 30213 63404006
Blood ketone body 22.98 11.05 6 54797 50 63434169
Anaemia 22.88 11.05 368 54435 293062 63141157
Intensive care unit acquired weakness 22.66 11.05 12 54791 809 63433410
Secretion discharge 22.53 11.05 39 54764 12192 63422027
Disease progression 22.46 11.05 45 54758 122713 63311506
Generalised oedema 22.33 11.05 45 54758 15773 63418446
Dyspnoea exertional 22.18 11.05 107 54696 60195 63374024
Myocardial infarction 22.17 11.05 155 54648 99738 63334481
Psoriatic arthropathy 21.98 11.05 28 54775 91492 63342727
Ischaemic stroke 21.77 11.05 48 54755 17909 63416310
Insulin C-peptide decreased 21.69 11.05 5 54798 23 63434196
Eye irritation 21.48 11.05 54 54749 21917 63412302
Coronary artery disease 21.32 11.05 69 54734 32308 63401911
Endometrial disorder 20.96 11.05 11 54792 728 63433491
Retinopathy 20.82 11.05 19 54784 3100 63431119
Fall 20.28 11.05 462 54341 391872 63042347
Patella fracture 20.22 11.05 16 54787 2150 63432069
Loss of personal independence in daily activities 20.18 11.05 33 54770 97257 63336962
Wrong patient received product 19.96 11.05 16 54787 2191 63432028
Knee arthroplasty 19.88 11.05 11 54792 54195 63380024
Drug hypersensitivity 19.87 11.05 172 54631 310515 63123704
Blood ketone body increased 19.70 11.05 8 54795 292 63433927
Hospitalisation 19.46 11.05 133 54670 84948 63349271
General physical health deterioration 19.38 11.05 262 54541 201140 63233079
Diabetic hyperglycaemic coma 19.33 11.05 5 54798 40 63434179
Electrolyte imbalance 19.27 11.05 49 54754 20027 63414192
Hypersensitivity 19.18 11.05 161 54642 292524 63141695
Foetal exposure during pregnancy 19.17 11.05 66 54737 31896 63402323
Red blood cell sedimentation rate increased 19.14 11.05 7 54796 43975 63390244
Vitreous haemorrhage 18.83 11.05 15 54788 2035 63432184
Pertussis 18.79 11.05 10 54793 681 63433538
Intercepted product prescribing error 18.76 11.05 7 54796 203 63434016
Enterococcus test positive 18.68 11.05 12 54791 1161 63433058
Malnutrition 18.66 11.05 41 54762 15257 63418962
Peritonitis bacterial 18.59 11.05 22 54781 4857 63429362
Liver injury 18.54 11.05 15 54788 60505 63373714
Adverse drug reaction 18.52 11.05 25 54778 79689 63354530
Diabetic coma 18.44 11.05 10 54793 707 63433512
Oedema peripheral 18.43 11.05 247 54556 189264 63244955
Urine ketone body present 18.20 11.05 16 54787 2487 63431732
Product use in unapproved indication 18.20 11.05 86 54717 178994 63255225
Gastrointestinal disorder 17.86 11.05 56 54747 131183 63303036
Insomnia 17.67 11.05 111 54692 215141 63219078
Urinary tract infection 17.39 11.05 323 54480 264361 63169858
Gastric disorder 17.29 11.05 71 54732 37298 63396921
Medication error 17.27 11.05 90 54713 52194 63382025
Renal impairment 17.26 11.05 133 54670 88222 63345997
Fasting 17.24 11.05 4 54799 19 63434200
Pulmonary oedema 17.13 11.05 93 54710 54780 63379439
Inflammatory marker increased 16.99 11.05 25 54778 6814 63427405
Neuropathy peripheral 16.89 11.05 161 54642 113506 63320713
Dermatitis bullous 16.82 11.05 28 54775 8480 63425739
Blood cholesterol increased 16.75 11.05 35 54768 93997 63340222
Gestational hypertension 16.68 11.05 15 54788 2402 63431817
Hyperinsulinaemic hypoglycaemia 16.61 11.05 5 54798 73 63434146
Impaired gastric emptying 16.55 11.05 31 54772 10301 63423918
Chest pain 16.50 11.05 270 54533 215689 63218530
Euglycaemic diabetic ketoacidosis 16.43 11.05 18 54785 3656 63430563
Peripheral swelling 16.22 11.05 149 54654 265793 63168426
Thyroid cancer 16.14 11.05 22 54781 5589 63428630
C-reactive protein abnormal 15.99 11.05 10 54793 46086 63388133
Motor dysfunction 15.65 11.05 31 54772 10730 63423489
Dawn phenomenon 15.63 11.05 3 54800 4 63434215
Dry mouth 15.60 11.05 27 54776 77836 63356383
Foetal hypokinesia 15.49 11.05 8 54795 512 63433707
Sepsis 15.47 11.05 201 54602 152922 63281297
Hemiplegia 14.96 11.05 28 54775 9295 63424924
Caesarean section 14.74 11.05 40 54763 16992 63417227
Anuria 14.60 11.05 33 54770 12518 63421701
End stage renal disease 14.56 11.05 23 54780 6670 63427549
Nasopharyngitis 14.42 11.05 145 54658 254112 63180107
Ketosis 14.26 11.05 8 54795 605 63433614
Congestive hepatopathy 14.18 11.05 15 54788 2927 63431292
Vascular parkinsonism 14.02 11.05 5 54798 127 63434092
Infusion site pain 13.99 11.05 39 54764 16830 63417389
Renal disorder 13.97 11.05 61 54742 32913 63401306
Pancreatic disorder 13.93 11.05 14 54789 2574 63431645
Peripheral sensorimotor neuropathy 13.81 11.05 11 54792 1492 63432727
Cutaneous amyloidosis 13.78 11.05 3 54800 10 63434209
Chronic obstructive pulmonary disease 13.75 11.05 97 54706 62589 63371630
Incorrect product dosage form administered 13.50 11.05 5 54798 142 63434077
Premature baby 13.48 11.05 44 54759 20691 63413528
Tachypnoea 13.38 11.05 39 54764 17263 63416956
Blood pressure increased 13.27 11.05 205 54598 161857 63272362
Adjustment disorder 13.23 11.05 15 54788 3163 63431056
Sensory loss 13.13 11.05 28 54775 10210 63424009
Fatigue 13.13 11.05 630 54173 887398 62546821
Product prescribing error 13.00 11.05 51 54752 26238 63407981
Blindness unilateral 12.96 11.05 21 54782 6220 63427999
Device expulsion 12.93 11.05 7 54796 34915 63399304
Bursitis 12.90 11.05 8 54795 37033 63397186
Hypoacusis 12.89 11.05 48 54755 24103 63410116
Postprandial hypoglycaemia 12.72 11.05 4 54799 68 63434151
Flank pain 12.70 11.05 37 54766 16373 63417846
Cellulitis 12.63 11.05 117 54686 81841 63352378
Febrile neutropenia 12.55 11.05 56 54747 118393 63315826
Hypervolaemia 12.37 11.05 53 54750 28360 63405859
Listeraemia 12.36 11.05 4 54799 75 63434144
Adenocarcinoma pancreas 12.35 11.05 9 54794 1069 63433150
White blood cell count decreased 12.32 11.05 70 54733 139034 63295185
Arteriosclerosis 12.30 11.05 27 54776 10039 63424180
Sinus congestion 12.28 11.05 39 54764 18084 63416135
Skin haemorrhage 12.25 11.05 27 54776 10067 63424152
Product name confusion 12.21 11.05 4 54799 78 63434141
Localised infection 12.13 11.05 55 54748 30155 63404064
Drug abuse 12.08 11.05 28 54775 72490 63361729
Cardiac death 11.87 11.05 7 54796 582 63433637
Polydipsia 11.84 11.05 15 54788 3549 63430670
Pyelonephritis 11.81 11.05 38 54765 17740 63416479
Pallor 11.79 11.05 55 54748 30513 63403706
Infection 11.66 11.05 134 54669 229039 63205180
Hypertriglyceridaemia 11.58 11.05 20 54783 6239 63427980
Dehydration 11.53 11.05 212 54591 173142 63261077
Hepatic cirrhosis 11.44 11.05 47 54756 24687 63409532
Toe amputation 11.25 11.05 11 54792 1956 63432263
Coronary artery occlusion 11.20 11.05 23 54780 8168 63426051
Gastroschisis 11.16 11.05 6 54797 417 63433802
Blood potassium increased 11.15 11.05 38 54765 18271 63415948

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood glucose increased 1879.50 11.16 1118 42588 65600 34847625
Hypoglycaemia 1193.58 11.16 780 42926 53860 34859365
Blood glucose decreased 421.63 11.16 241 43465 12996 34900229
Diabetic ketoacidosis 386.73 11.16 255 43451 17777 34895448
Hyperglycaemia 374.23 11.16 344 43362 39136 34874089
Diabetes mellitus inadequate control 339.77 11.16 211 43495 13253 34899972
Glycosylated haemoglobin increased 299.28 11.16 183 43523 11177 34902048
Blood glucose abnormal 290.29 11.16 144 43562 5808 34907417
Incorrect dose administered 236.38 11.16 272 43434 40243 34872982
Wrong product administered 156.19 11.16 92 43614 5242 34907983
Hypoglycaemic coma 155.81 11.16 71 43635 2360 34910865
Hypoglycaemic unconsciousness 146.74 11.16 50 43656 748 34912477
Anti-insulin antibody positive 128.72 11.16 33 43673 165 34913060
Toxicity to various agents 122.02 11.16 49 43657 200313 34712912
Blood glucose fluctuation 121.69 11.16 71 43635 3973 34909252
Diabetic retinopathy 94.67 11.16 46 43660 1771 34911454
Accidental underdose 89.81 11.16 31 43675 483 34912742
Underdose 87.93 11.16 97 43609 13683 34899542
Intercepted product selection error 83.22 11.16 16 43690 10 34913215
Ketoacidosis 76.63 11.16 54 43652 4189 34909036
Product storage error 71.50 11.16 68 43638 8054 34905171
Hypoglycaemic seizure 69.56 11.16 23 43683 312 34912913
Drug abuse 62.28 11.16 23 43683 99073 34814152
Off label use 56.37 11.16 302 43404 419222 34494003
Product dispensing error 56.13 11.16 53 43653 6221 34907004
Hypoglycaemia unawareness 55.65 11.16 16 43690 131 34913094
Completed suicide 54.96 11.16 27 43679 98141 34815084
Acute kidney injury 54.77 11.16 602 43104 304386 34608839
Infusion site pain 51.65 11.16 41 43665 3810 34909415
Diabetic metabolic decompensation 47.90 11.16 29 43677 1737 34911488
Infective pulmonary exacerbation of cystic fibrosis 47.10 11.16 50 43656 6751 34906474
Diabetic neuropathy 46.51 11.16 40 43666 4157 34909068
Product complaint 45.65 11.16 46 43660 5844 34907381
Insulin resistance 44.65 11.16 20 43686 638 34912587
Foetal disorder 43.30 11.16 21 43685 805 34912420
Intercepted product dispensing error 40.67 11.16 11 43695 70 34913155
Anti-insulin antibody 39.78 11.16 9 43697 23 34913202
Blindness 38.42 11.16 68 43638 14918 34898307
Anti-insulin antibody increased 36.15 11.16 10 43696 70 34913155
Impaired gastric emptying 34.44 11.16 31 43675 3422 34909803
Neutropenia neonatal 34.04 11.16 17 43689 695 34912530
Visual impairment 32.82 11.16 109 43597 35693 34877532
Wrong technique in product usage process 32.49 11.16 109 43597 35877 34877348
Cutaneous amyloidosis 32.26 11.16 8 43698 34 34913191
Medication error 32.11 11.16 87 43619 25478 34887747
Retinopathy 32.11 11.16 24 43682 2040 34911185
Febrile neutropenia 31.15 11.16 79 43627 136770 34776455
Sopor 31.02 11.16 55 43651 12081 34901144
Hypoaldosteronism 30.98 11.16 11 43695 187 34913038
Pancreatic carcinoma 30.42 11.16 46 43660 8855 34904370
Product dose omission issue 30.13 11.16 254 43452 119457 34793768
Hyperkalaemia 29.20 11.16 167 43539 69222 34844003
Diabetic gastroparesis 27.71 11.16 9 43697 115 34913110
Skin ulcer 27.30 11.16 75 43631 22141 34891084
Diaphragmatic disorder 27.23 11.16 18 43688 1257 34911968
Type 1 diabetes mellitus 27.20 11.16 30 43676 4228 34908997
Oedematous pancreatitis 27.15 11.16 13 43693 484 34912741
Dehydration 26.73 11.16 264 43442 129705 34783520
Left atrial dilatation 26.23 11.16 21 43685 1975 34911250
Diabetic foot infection 26.09 11.16 14 43692 665 34912560
Toe amputation 25.85 11.16 23 43683 2501 34910724
Visual acuity reduced 25.56 11.16 60 43646 16089 34897136
Systemic infection 25.45 11.16 32 43674 5180 34908045
Hospitalisation 25.30 11.16 139 43567 56763 34856462
Shock hypoglycaemic 25.24 11.16 8 43698 94 34913131
Infusion site induration 25.20 11.16 10 43696 234 34912991
Diabetic nephropathy 25.05 11.16 21 43685 2107 34911118
Diabetic coma 24.72 11.16 15 43691 902 34912323
Loss of personal independence in daily activities 23.90 11.16 6 43700 33173 34880052
Haemoglobin increased 23.49 11.16 25 43681 3384 34909841
Product monitoring error 23.17 11.16 28 43678 4353 34908872
Haematocrit increased 23.13 11.16 20 43686 2093 34911132
Leg amputation 22.40 11.16 20 43686 2184 34911041
Diabetic foot 22.02 11.16 22 43684 2766 34910459
Mucosal dryness 21.88 11.16 16 43690 1315 34911910
Treatment failure 21.69 11.16 16 43690 46681 34866544
Ketosis 21.21 11.16 11 43695 487 34912738
Cardiac failure congestive 21.11 11.16 177 43529 83093 34830132
Renal disorder 21.10 11.16 75 43631 25405 34887820
Premature baby 20.95 11.16 63 43643 19570 34893655
VACTERL syndrome 20.78 11.16 6 43700 50 34913175
Pseudolymphoma 20.75 11.16 12 43694 660 34912565
Acute respiratory failure 20.64 11.16 85 43621 30843 34882382
Weight increased 20.61 11.16 192 43514 92841 34820384
Increased insulin requirement 20.59 11.16 7 43699 104 34913121
Loss of consciousness 20.57 11.16 175 43531 82492 34830733
Oedema peripheral 19.81 11.16 233 43473 119579 34793646
Cerebrovascular accident 19.78 11.16 177 43529 84634 34828591
Multiple organ dysfunction syndrome 19.16 11.16 42 43664 76524 34836701
Pseudohyponatraemia 19.13 11.16 6 43700 68 34913157
Neutropenia 18.71 11.16 117 43589 156661 34756564
Product use in unapproved indication 18.34 11.16 80 43626 117419 34795806
Mucosal inflammation 18.24 11.16 13 43693 38609 34874616
Blood ketone body 18.17 11.16 6 43700 81 34913144
Device operational issue 17.56 11.16 7 43699 166 34913059
Diabetes mellitus 17.27 11.16 109 43597 46764 34866461
Malignant neoplasm progression 16.95 11.16 55 43651 87991 34825234
Balanoposthitis 16.57 11.16 13 43693 1187 34912038
Localised infection 16.52 11.16 54 43652 17533 34895692
Rash 16.32 11.16 189 43517 222563 34690662
Drug resistance 16.30 11.16 6 43700 25921 34887304
Treatment noncompliance 16.28 11.16 74 43632 28026 34885199
Fall 16.12 11.16 349 43357 202536 34710689
Somnolence 15.95 11.16 78 43628 111038 34802187
Chronic kidney disease 15.92 11.16 97 43609 41113 34872112
Injection site pain 15.83 11.16 93 43613 38912 34874313
Incorrect product formulation administered 15.77 11.16 4 43702 19 34913206
Cold sweat 15.69 11.16 37 43669 9950 34903275
Intentional product use issue 15.64 11.16 32 43674 59784 34853441
Serotonin syndrome 15.58 11.16 3 43703 19930 34893295
Expired product administered 15.50 11.16 20 43686 3321 34909904
Disease progression 15.43 11.16 76 43630 108001 34805224
Cellulitis 15.29 11.16 116 43590 52835 34860390
Product name confusion 15.18 11.16 5 43701 67 34913158
Injury associated with device 15.15 11.16 12 43694 1111 34912114
Arthralgia 15.03 11.16 138 43568 169903 34743322
Road traffic accident 14.99 11.16 52 43654 17398 34895827
Poor quality product administered 14.97 11.16 15 43691 1892 34911333
Agitation 14.76 11.16 31 43675 57368 34855857
Osteomyelitis 14.67 11.16 49 43657 16087 34897138
Hemivertebra 14.64 11.16 6 43700 153 34913072
Intraventricular haemorrhage 14.63 11.16 20 43686 3511 34909714
Hypervolaemia 14.62 11.16 56 43650 19653 34893572
Drug dependence 14.57 11.16 6 43700 24211 34889014
Meningitis aseptic 14.49 11.16 19 43687 3205 34910020
Foot amputation 14.48 11.16 10 43696 751 34912474
Lipohypertrophy 14.37 11.16 7 43699 271 34912954
Rheumatoid arthritis 14.31 11.16 16 43690 38222 34875003
Drug ineffective for unapproved indication 14.07 11.16 6 43700 23709 34889516
Enterobacter pneumonia 13.92 11.16 5 43701 88 34913137
Hypoglycaemic encephalopathy 13.88 11.16 7 43699 292 34912933
Bone marrow failure 13.62 11.16 10 43696 29243 34883982
Diabetic hyperglycaemic coma 13.58 11.16 4 43702 36 34913189
Peritonitis bacterial 13.49 11.16 26 43680 6084 34907141
Epididymitis 13.47 11.16 16 43690 2443 34910782
Pulmonary embolism 13.46 11.16 62 43644 89684 34823541
Joint swelling 13.28 11.16 35 43671 59855 34853370
Presyncope 13.21 11.16 53 43653 19006 34894219
Oedematous kidney 13.20 11.16 4 43702 40 34913185
Cystic fibrosis 12.94 11.16 13 43693 1645 34911580
Atrial fibrillation 12.94 11.16 220 43486 122173 34791052
Weight loss poor 12.93 11.16 6 43700 208 34913017
Myelosuppression 12.91 11.16 4 43702 19261 34893964
Hepatic encephalopathy 12.82 11.16 44 43662 14641 34898584
Injection site nodule 12.78 11.16 13 43693 1670 34911555
Primary biliary cholangitis 12.64 11.16 6 43700 219 34913006
Insulin C-peptide decreased 12.62 11.16 4 43702 47 34913178
Post streptococcal glomerulonephritis 12.41 11.16 5 43701 122 34913103
Blood ketone body present 12.25 11.16 4 43702 52 34913173
Glycogen storage disease type VIII 12.24 11.16 3 43703 12 34913213
Impaired insulin secretion 12.24 11.16 3 43703 12 34913213
Blindness unilateral 12.15 11.16 21 43685 4521 34908704
Impaired fasting glucose 12.13 11.16 6 43700 240 34912985
Diabetic gangrene 11.95 11.16 6 43700 248 34912977
Postprandial hypoglycaemia 11.87 11.16 3 43703 14 34913211
Toxic epidermal necrolysis 11.79 11.16 56 43650 21590 34891635
Cataract 11.65 11.16 64 43642 26122 34887103
Eye haemorrhage 11.64 11.16 20 43686 4285 34908940
Lichenoid keratosis 11.62 11.16 15 43691 2493 34910732
Respiratory depression 11.58 11.16 3 43703 16242 34896983
Neuroleptic malignant syndrome 11.53 11.16 4 43702 17930 34895295
Sedation 11.41 11.16 6 43700 21000 34892225
Retrognathia 11.30 11.16 6 43700 279 34912946
Blood pressure fluctuation 11.28 11.16 9 43697 25240 34887985
Pancreatic carcinoma metastatic 11.21 11.16 16 43690 2924 34910301

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 2211.74 10.04 1314 75166 100280 79567628
Blood glucose increased 1977.45 10.04 1280 75200 113695 79554213
Diabetic ketoacidosis 729.41 10.04 437 76043 33685 79634223
Diabetes mellitus inadequate control 661.02 10.04 364 76116 23900 79644008
Hyperglycaemia 614.92 10.04 522 75958 69813 79598095
Blood glucose decreased 589.39 10.04 347 76133 25887 79642021
Glycosylated haemoglobin increased 433.22 10.04 255 76225 19005 79648903
Blood glucose fluctuation 246.91 10.04 123 76357 6559 79661349
Blood glucose abnormal 243.13 10.04 142 76338 10424 79657484
Hypoglycaemic coma 241.48 10.04 109 76371 4651 79663257
Acute kidney injury 166.72 10.04 956 75524 518448 79149460
Ketoacidosis 166.18 10.04 100 76380 7754 79660154
Anti-insulin antibody positive 153.28 10.04 39 76441 257 79667651
Toxicity to various agents 150.37 10.04 111 76369 421429 79246479
Hypoglycaemic unconsciousness 132.91 10.04 48 76432 1135 79666773
Wrong product administered 120.28 10.04 86 76394 8926 79658982
Hypoglycaemic seizure 113.86 10.04 39 76441 785 79667123
Infective pulmonary exacerbation of cystic fibrosis 97.35 10.04 88 76392 12763 79655145
Off label use 94.56 10.04 499 75981 906716 78761192
Product complaint 94.48 10.04 88 76392 13261 79654647
Drug intolerance 93.50 10.04 70 76410 264049 79403859
Gangrene 91.77 10.04 73 76407 8891 79659017
Diabetic retinopathy 91.21 10.04 49 76431 3057 79664851
Systemic lupus erythematosus 89.60 10.04 7 76473 121142 79546766
Cardiac failure congestive 86.71 10.04 317 76163 142085 79525823
Insulin resistance 84.27 10.04 36 76444 1343 79666565
Completed suicide 82.12 10.04 69 76411 245698 79422210
Incorrect dose administered 82.00 10.04 208 76272 76422 79591486
Eye haemorrhage 80.24 10.04 70 76410 9687 79658221
Glossodynia 79.23 10.04 5 76475 103332 79564576
Treatment failure 77.81 10.04 33 76447 170453 79497455
Anti-insulin antibody increased 77.68 10.04 19 76461 104 79667804
Hypoglycaemia unawareness 74.19 10.04 21 76459 217 79667691
Rash 68.89 10.04 303 76177 578055 79089853
Drug ineffective 68.24 10.04 686 75794 1080227 78587681
Therapeutic product effect decreased 68.20 10.04 36 76444 163827 79504081
Joint swelling 67.36 10.04 108 76372 288538 79379370
Arterial occlusive disease 66.21 10.04 59 76421 8397 79659511
Hyperkalaemia 64.91 10.04 249 76231 114149 79553759
Loss of consciousness 63.69 10.04 324 76156 167619 79500289
Alopecia 63.53 10.04 77 76403 231278 79436630
Synovitis 62.90 10.04 33 76447 150701 79517207
Pericarditis 62.58 10.04 12 76468 104224 79563684
Arthralgia 61.94 10.04 310 76170 571493 79096415
Infusion related reaction 61.78 10.04 78 76402 230159 79437749
Increased insulin requirement 60.56 10.04 17 76463 170 79667738
Anti-insulin antibody 59.50 10.04 14 76466 63 79667845
Abdominal discomfort 59.26 10.04 93 76387 250634 79417274
Arthropathy 55.22 10.04 53 76427 177058 79490850
Nasal obstruction 54.90 10.04 31 76449 2133 79665775
Accidental underdose 54.32 10.04 23 76457 839 79667069
Acute respiratory failure 53.97 10.04 152 76328 59389 79608519
Drug abuse 52.71 10.04 47 76433 162644 79505264
Sopor 52.58 10.04 105 76375 32905 79635003
Product administration error 50.37 10.04 101 76379 31745 79636163
Diabetic neuropathy 49.92 10.04 44 76436 6172 79661736
Cutaneous amyloidosis 48.62 10.04 11 76469 40 79667868
Pancreatic carcinoma 47.79 10.04 62 76418 13515 79654393
Throat clearing 46.56 10.04 30 76450 2624 79665284
Helicobacter infection 46.41 10.04 6 76474 69698 79598210
Lower respiratory tract infection 46.01 10.04 34 76446 129186 79538722
Angina pectoris 45.85 10.04 131 76349 51601 79616307
General physical health deterioration 45.45 10.04 433 76047 274805 79393103
Oedema peripheral 45.24 10.04 404 76076 251884 79416024
Shock hypoglycaemic 42.80 10.04 14 76466 243 79667665
Multi-organ disorder 42.33 10.04 28 76452 2560 79665348
Type 1 diabetes mellitus 42.14 10.04 42 76438 6877 79661031
Dehydration 41.24 10.04 391 76089 247796 79420112
Diabetic metabolic decompensation 40.38 10.04 30 76450 3302 79664606
Musculoskeletal stiffness 40.31 10.04 66 76414 174942 79492966
Diabetic foot 40.25 10.04 31 76449 3601 79664307
Product storage error 37.91 10.04 61 76419 16165 79651743
Cerebrovascular accident 37.30 10.04 266 76214 155026 79512882
Device operational issue 37.02 10.04 14 76466 378 79667530
Hepatic enzyme increased 35.75 10.04 76 76404 182534 79485374
Intentional product use issue 35.37 10.04 57 76423 152055 79515853
Muscle injury 35.36 10.04 3 76477 48558 79619350
Cataract 35.05 10.04 135 76345 61985 79605923
Diabetes mellitus 34.57 10.04 158 76322 78232 79589676
Diabetic nephropathy 34.53 10.04 26 76454 2921 79664987
Cystic fibrosis 34.27 10.04 29 76451 3851 79664057
Stomatitis 34.12 10.04 55 76425 146702 79521206
Contraindicated product administered 33.92 10.04 62 76418 157476 79510432
Anaemia 33.81 10.04 607 75873 444408 79223500
Irritable bowel syndrome 33.68 10.04 9 76471 62232 79605676
Treatment noncompliance 33.18 10.04 118 76362 52150 79615758
Pre-eclampsia 32.69 10.04 37 76443 7004 79660904
Systemic infection 31.96 10.04 43 76437 9709 79658199
Folliculitis 31.94 10.04 7 76473 55373 79612535
Medication error 31.50 10.04 140 76340 68502 79599406
Peritonitis bacterial 31.07 10.04 42 76438 9525 79658383
Loss of personal independence in daily activities 30.47 10.04 32 76448 102548 79565360
Swelling 29.87 10.04 107 76373 216604 79451304
Transcription medication error 28.36 10.04 12 76468 437 79667471
Red blood cell sedimentation rate increased 28.19 10.04 5 76475 45937 79621971
Toe amputation 28.09 10.04 26 76454 3885 79664023
Keratitis 27.74 10.04 27 76453 4295 79663613
Hyperinsulinaemic hypoglycaemia 27.47 10.04 9 76471 157 79667751
Carotid artery thrombosis 27.34 10.04 23 76457 3030 79664878
Diabetic foot infection 27.31 10.04 14 76466 793 79667115
Impaired gastric emptying 27.08 10.04 41 76439 10312 79657596
Renal failure 26.89 10.04 303 76177 200665 79467243
Hypoaldosteronism 26.68 10.04 11 76469 375 79667533
Ill-defined disorder 26.63 10.04 15 76465 65860 79602048
Asthenia 26.50 10.04 660 75820 511029 79156879
Diaphragmatic disorder 26.39 10.04 18 76462 1732 79666176
Neurologic neglect syndrome 26.24 10.04 22 76458 2885 79665023
Febrile neutropenia 26.23 10.04 123 76357 230876 79437032
Hypervolaemia 25.92 10.04 95 76385 42595 79625313
Ketosis 25.55 10.04 15 76465 1111 79666797
Rhonchi 25.51 10.04 25 76455 4011 79663897
Infusion site induration 25.44 10.04 15 76465 1120 79666788
Rheumatoid arthritis 24.87 10.04 109 76371 208361 79459547
Blood ketone body 24.61 10.04 8 76472 136 79667772
Postprandial hypoglycaemia 24.09 10.04 7 76473 80 79667828
Diabetic coma 24.09 10.04 15 76465 1236 79666672
Diabetic retinal oedema 24.03 10.04 10 76470 349 79667559
Hip arthroplasty 23.99 10.04 3 76477 35753 79632155
Blister 23.99 10.04 49 76431 119427 79548481
Syncope 23.76 10.04 270 76210 179179 79488729
Hypersensitivity 23.53 10.04 151 76329 262088 79405820
Chronic kidney disease 23.24 10.04 125 76355 66029 79601879
Renal impairment 23 10.04 242 76238 157541 79510367
Cellulitis 22.89 10.04 181 76299 108879 79559029
Product name confusion 22.82 10.04 8 76472 173 79667735
Sepsis 22.77 10.04 374 76106 269054 79398854
Left atrial dilatation 22.72 10.04 21 76459 3132 79664776
Fall 22.64 10.04 620 75860 487009 79180899
Product dose omission issue 22.57 10.04 348 76132 247189 79420719
Retinopathy 22.56 10.04 23 76457 3868 79664040
Renal disorder 22.53 10.04 90 76390 42015 79625893
Atrial fibrillation 22.38 10.04 289 76191 197597 79470311
Weight increased 22.33 10.04 382 76098 277004 79390904
Endometrial disorder 21.74 10.04 11 76469 606 79667302
Myelosuppression 21.48 10.04 6 76474 40290 79627618
Gastrointestinal disorder 21.38 10.04 54 76426 122151 79545757
Mobility decreased 21.37 10.04 54 76426 122121 79545787
Hypovolaemia 21.01 10.04 50 76430 17641 79650267
Epileptic encephalopathy 20.93 10.04 10 76470 486 79667422
Product dispensing error 20.89 10.04 42 76438 13221 79654687
Malignant neoplasm progression 20.89 10.04 64 76416 135926 79531982
Disease progression 20.44 10.04 99 76381 184263 79483645
Epididymitis 20.36 10.04 16 76464 1914 79665994
Product use issue 20.29 10.04 118 76362 209704 79458204
Haematocrit increased 20.11 10.04 22 76458 4012 79663896
Product use in unapproved indication 20.07 10.04 149 76331 250210 79417698
Oedematous pancreatitis 19.99 10.04 13 76467 1155 79666753
Personality disorder 19.99 10.04 27 76453 6119 79661789
Vitreous haemorrhage 19.83 10.04 21 76459 3692 79664216
Foot amputation 19.64 10.04 12 76468 956 79666952
Drug resistance 19.52 10.04 8 76472 42205 79625703
Adverse drug reaction 19.39 10.04 21 76459 66371 79601537
Diabetic hyperglycaemic coma 19.34 10.04 6 76474 87 79667821
Hepatic encephalopathy 19.31 10.04 59 76421 24107 79643801
Presyncope 19.04 10.04 84 76396 40970 79626938
Electrolyte imbalance 18.99 10.04 69 76411 30812 79637096
Eye discharge 18.85 10.04 26 76454 6008 79661900
Discomfort 18.67 10.04 60 76420 125557 79542351
Haemoglobin increased 18.53 10.04 26 76454 6106 79661802
Hyperhidrosis 18.30 10.04 224 76256 151268 79516640
Patella fracture 18.30 10.04 15 76465 1906 79666002
Localised infection 18.28 10.04 78 76402 37497 79630411
Pertussis 18.15 10.04 11 76469 864 79667044
Thyroid disorder 18.05 10.04 41 76439 14038 79653870
Glycogen storage disease type VIII 18.03 10.04 4 76476 13 79667895
Glomerular filtration rate decreased 17.75 10.04 55 76425 22647 79645261
Blood insulin increased 17.49 10.04 8 76472 352 79667556
Dyspnoea exertional 17.45 10.04 143 76337 86930 79580978
Diabetic gastroparesis 17.45 10.04 8 76472 354 79667554
Neutropenia 17.43 10.04 184 76296 287526 79380382
Neuropathic arthropathy 17.38 10.04 8 76472 357 79667551
Pseudolymphoma 17.24 10.04 12 76468 1193 79666715
Balanoposthitis 17.10 10.04 11 76469 959 79666949
Blindness 17.10 10.04 63 76417 28320 79639588
Dyspnoea 17.07 10.04 994 75486 856031 78811877
Pseudohyponatraemia 17.06 10.04 6 76474 131 79667777
Croup infectious 16.97 10.04 10 76470 746 79667162
C-reactive protein abnormal 16.86 10.04 13 76467 48354 79619554
Dermatitis bullous 16.64 10.04 40 76440 14205 79653703
Neutropenic sepsis 16.49 10.04 3 76477 27061 79640847
Hemiplegia 16.44 10.04 41 76439 14898 79653010
Cognitive disorder 16.44 10.04 26 76454 69900 79598008
Insomnia 16.43 10.04 153 76327 245017 79422891
Euglycaemic diabetic ketoacidosis 16.36 10.04 26 76454 6818 79661090
Secretion discharge 16.29 10.04 41 76439 14981 79652927
Cold sweat 16.22 10.04 47 76433 18652 79649256
Drug hypersensitivity 16.20 10.04 196 76284 298720 79369188
Intensive care unit acquired weakness 16.16 10.04 14 76466 1919 79665989
Insulin C-peptide decreased 16.15 10.04 5 76475 72 79667836
Infection 16.13 10.04 151 76329 241561 79426347
Intercepted product dispensing error 16.11 10.04 6 76474 155 79667753
Blood creatinine increased 16.10 10.04 223 76257 154834 79513074
Psychotic disorder 15.92 10.04 10 76470 41392 79626516
Hospitalisation 15.89 10.04 149 76331 94087 79573821
Pseudomonal bacteraemia 15.70 10.04 17 76463 3065 79664843
Polydipsia 15.66 10.04 25 76455 6580 79661328
Underdose 15.50 10.04 68 76412 33083 79634825
Blood cholesterol increased 15.43 10.04 36 76444 83684 79584224
Mucosal dryness 15.34 10.04 18 76462 3541 79664367
Intraventricular haemorrhage 15.18 10.04 21 76459 4866 79663042
Enterococcus test positive 15.14 10.04 14 76466 2090 79665818
Nasopharyngitis 15.12 10.04 163 76317 253718 79414190
Bone marrow failure 15.11 10.04 16 76464 51091 79616817
C-reactive protein increased 15.05 10.04 68 76412 128959 79538949
Product monitoring error 14.99 10.04 29 76451 8877 79659031
Dawn phenomenon 14.91 10.04 3 76477 5 79667903
Neuroleptic malignant syndrome 14.88 10.04 4 76476 27555 79640353
Gastric disorder 14.72 10.04 73 76407 37360 79630548
Knee arthroplasty 14.60 10.04 12 76468 43236 79624672
Generalised oedema 14.60 10.04 53 76427 23656 79644252
Serotonin syndrome 14.58 10.04 13 76467 45014 79622894
Mucosal inflammation 14.33 10.04 32 76448 75548 79592360
Drug dependence 14.16 10.04 11 76469 40758 79627150
Urinary tract obstruction 14.10 10.04 20 76460 4745 79663163
Somogyi phenomenon 13.96 10.04 3 76477 8 79667900
Blood pressure fluctuation 13.94 10.04 27 76453 67118 79600790
Posterior reversible encephalopathy syndrome 13.85 10.04 4 76476 26277 79641631
Mouth ulceration 13.79 10.04 10 76470 38384 79629524
Tendonitis 13.77 10.04 3 76477 23827 79644081
Vascular parkinsonism 13.62 10.04 5 76475 124 79667784
Adenocarcinoma pancreas 13.62 10.04 13 76467 2020 79665888
Malnutrition 13.60 10.04 50 76430 22452 79645456
Acute myocardial infarction 13.59 10.04 123 76357 76913 79590995
Post streptococcal glomerulonephritis 13.55 10.04 5 76475 126 79667782
Product prescribing error 13.32 10.04 81 76399 44732 79623176
Leg amputation 13.31 10.04 17 76463 3649 79664259
Skin haemorrhage 13.31 10.04 33 76447 11948 79655960
Fibromyalgia 13.24 10.04 26 76454 64314 79603594
Expired product administered 13.17 10.04 24 76456 7027 79660881
Respiratory depression 13.16 10.04 5 76475 27625 79640283
Dry mouth 13.11 10.04 42 76438 87977 79579931
Fasting 13.09 10.04 4 76476 55 79667853
Hypoxia 13.05 10.04 154 76326 103089 79564819
Intercepted product selection error 13.04 10.04 3 76477 12 79667896
Extrapyramidal disorder 12.81 10.04 3 76477 22676 79645232
Enterobacter pneumonia 12.79 10.04 5 76475 148 79667760
Paraesthesia 12.70 10.04 108 76372 176215 79491693
Neck pain 12.67 10.04 34 76446 75383 79592525
Electrocardiogram abnormal 12.58 10.04 40 76440 16697 79651211
Device failure 12.57 10.04 22 76458 6239 79661669
Psoriatic arthropathy 12.49 10.04 36 76444 77963 79589945
Urinary tract infection 12.42 10.04 348 76132 274164 79393744
Blood ketone body increased 12.27 10.04 8 76472 714 79667194
Multiple sclerosis relapse 12.22 10.04 16 76464 46517 79621391
Diabetic complication 12.21 10.04 10 76470 1269 79666639
Hypercreatinaemia 12.18 10.04 6 76474 312 79667596
Urine ketone body present 12.11 10.04 16 76464 3549 79664359
Bursitis 12.03 10.04 10 76470 35834 79632074
Skin ulcer 11.99 10.04 91 76389 54059 79613849
Exposure during pregnancy 11.98 10.04 149 76331 100983 79566925
Chronic obstructive pulmonary disease 11.97 10.04 130 76350 85289 79582619
Varices oesophageal 11.97 10.04 21 76459 5970 79661938
Neutrophil count decreased 11.89 10.04 48 76432 93911 79573997
Basal cell carcinoma 11.86 10.04 11 76469 37364 79630544
Pancreatitis 11.85 10.04 109 76371 68466 79599442
Product quality issue 11.83 10.04 64 76416 33876 79634032
Dystonia 11.76 10.04 3 76477 21396 79646512
Urinary tract candidiasis 11.73 10.04 8 76472 769 79667139
Gastrointestinal haemorrhage 11.71 10.04 203 76277 147516 79520392
Chest pain 11.70 10.04 354 76126 281950 79385958
Peripheral arterial occlusive disease 11.66 10.04 25 76455 8233 79659675
Heart rate decreased 11.59 10.04 32 76448 70284 79597624
White blood cell count decreased 11.56 10.04 120 76360 188168 79479740
Migraine 11.52 10.04 44 76436 87449 79580459
Pancreatic carcinoma metastatic 11.47 10.04 16 76464 3737 79664171
Obstructive airways disorder 11.42 10.04 60 76420 31399 79636509
Listeraemia 11.39 10.04 4 76476 87 79667821
Somnolence 11.37 10.04 161 76319 238820 79429088
Sleep disorder 11.33 10.04 43 76437 85634 79582274
Vomiting 11.33 10.04 762 75718 665066 79002842
Visual acuity reduced 11.25 10.04 57 76423 29412 79638496
Pyelonephritis 11.24 10.04 44 76436 20344 79647564
Early satiety 11.19 10.04 10 76470 1429 79666479
Renal transplant 11.18 10.04 13 76467 2534 79665374
Dyskinesia 11.15 10.04 16 76464 44757 79623151
Pain 11.06 10.04 557 75923 703245 78964663
Blood ketone body present 10.94 10.04 4 76476 98 79667810
Myocardial infarction 10.87 10.04 242 76238 183887 79484021
Agitation 10.78 10.04 54 76426 99661 79568247
Hypoaesthesia 10.73 10.04 115 76365 179237 79488671
Gestational hypertension 10.70 10.04 11 76469 1868 79666040
Sedation 10.66 10.04 21 76459 51874 79616034
Cardiac disorder 10.60 10.04 103 76377 65654 79602254
Ischaemic stroke 10.57 10.04 61 76419 33070 79634838
Congestive hepatopathy 10.49 10.04 17 76463 4530 79663378
Insulin autoimmune syndrome 10.45 10.04 6 76474 426 79667482
Pulmonary oedema 10.44 10.04 130 76350 88124 79579784
Carbon dioxide abnormal 10.40 10.04 6 76474 430 79667478
Device expulsion 10.29 10.04 6 76474 25855 79642053
Ischaemic hepatitis 10.28 10.04 15 76465 3649 79664259
Hypoxic-ischaemic encephalopathy 10.28 10.04 23 76457 7797 79660111
Necrobiosis lipoidica diabeticorum 10.27 10.04 3 76477 35 79667873
Myocarditis 10.24 10.04 4 76476 21729 79646179
Pancreatitis acute 10.23 10.04 82 76398 49522 79618386
Aggression 10.14 10.04 21 76459 50937 79616971
Insulin C-peptide increased 10.12 10.04 4 76476 122 79667786
Itching scar 10.12 10.04 3 76477 37 79667871
Glycosylated haemoglobin decreased 10.06 10.04 7 76473 695 79667213

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10AB04 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
INSULINS AND ANALOGUES
Insulins and analogues for injection, fast-acting
ATC A10AC04 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
INSULINS AND ANALOGUES
Insulins and analogues for injection, intermediate-acting
ATC A10AD04 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
INSULINS AND ANALOGUES
Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
FDA CS M0011417 Insulin
FDA Chemical/Ingredient N0000004931 Insulin
FDA EPC N0000175453 Insulin Analog
CHEBI has role CHEBI:35526 antidiabetic
FDA EPC N0000175944 Insulin
MeSH PA D007004 Hypoglycemic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352
Diabetes mellitus type 1 indication 46635009 DOID:9744




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Insulin receptor Kinase AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
D04477 KEGG_DRUG
4020998 VUID
N0000179468 NUI
4017559 VANDF
4017569 VANDF
4019786 VANDF
4020998 VANDF
4021213 VANDF
CHEBI:5931 CHEBI
CHEMBL1201538 ChEMBL_ID
CHEMBL1201611 ChEMBL_ID
DB00046 DRUGBANK_ID
DB00030 DRUGBANK_ID
135805 RXNORM
283144 MMSL
335485 MMSL
4882 MMSL
4885 MMSL
4886 MMSL
6127 MMSL
8603 MMSL
d00262 MMSL
d04369 MMSL
d04373 MMSL
d04511 MMSL
000869 NDDF
000870 NDDF
006061 NDDF
006518 NDDF
007750 NDDF
126210001 SNOMEDCT_US
388454007 SNOMEDCT_US
412210000 SNOMEDCT_US
417423002 SNOMEDCT_US
420609005 SNOMEDCT_US
426313003 SNOMEDCT_US
96367001 SNOMEDCT_US
D061268 MESH_DESCRIPTOR_UI
C0293359 UMLSCUI
C0795635 UMLSCUI
7278 INN_ID
16132438 PUBCHEM_CID
5186 INN_ID
118984375 PUBCHEM_CID
GFX7QIS1II UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Humalog HUMAN PRESCRIPTION DRUG LABEL 1 0002-7510 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 34 sections
Humalog HUMAN PRESCRIPTION DRUG LABEL 1 0002-7510 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 34 sections
Humalog HUMAN PRESCRIPTION DRUG LABEL 1 0002-7510 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 34 sections
Humalog Mix75/25 HUMAN PRESCRIPTION DRUG LABEL 1 0002-7511 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 30 sections
Humalog Mix75/25 HUMAN PRESCRIPTION DRUG LABEL 1 0002-7511 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 30 sections
Humalog Mix50/50 HUMAN PRESCRIPTION DRUG LABEL 1 0002-7512 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 30 sections
Humalog Mix50/50 HUMAN PRESCRIPTION DRUG LABEL 1 0002-7512 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 30 sections
Humalog HUMAN PRESCRIPTION DRUG LABEL 1 0002-7516 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 34 sections
Humalog HUMAN PRESCRIPTION DRUG LABEL 1 0002-7516 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 34 sections
Humalog HUMAN PRESCRIPTION DRUG LABEL 1 0002-7516 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 34 sections
Humalog HUMAN PRESCRIPTION DRUG LABEL 1 0002-7533 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 34 sections
HumalogKwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-7712 INJECTION, SOLUTION 200 [iU] SUBCUTANEOUS BLA 34 sections
HumalogKwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-7712 INJECTION, SOLUTION 200 [iU] SUBCUTANEOUS BLA 34 sections
HumalogKwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-7712 INJECTION, SOLUTION 200 [iU] SUBCUTANEOUS BLA 34 sections
Humalog Junior KwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-7714 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 34 sections
Humalog Junior KwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-7714 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 34 sections
Humalog Junior KwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-7714 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 34 sections
LYUMJEV HUMAN PRESCRIPTION DRUG LABEL 1 0002-7726 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 34 sections
LYUMJEV HUMAN PRESCRIPTION DRUG LABEL 1 0002-7726 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 34 sections
LYUMJEV HUMAN PRESCRIPTION DRUG LABEL 1 0002-7726 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 34 sections
LYUMJEV HUMAN PRESCRIPTION DRUG LABEL 1 0002-7728 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 34 sections
LYUMJEV HUMAN PRESCRIPTION DRUG LABEL 1 0002-7728 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 34 sections
LYUMJEV HUMAN PRESCRIPTION DRUG LABEL 1 0002-7728 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 34 sections
Insulin Lispro HUMAN PRESCRIPTION DRUG LABEL 1 0002-7737 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 34 sections
Insulin Lispro HUMAN PRESCRIPTION DRUG LABEL 1 0002-7737 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 34 sections
Insulin Lispro HUMAN PRESCRIPTION DRUG LABEL 1 0002-7737 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 34 sections
Insulin Lispro Junior KwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-7752 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 34 sections
Insulin Lispro Junior KwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-7752 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 34 sections
Insulin Lispro Junior KwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-7752 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 34 sections
LYUMJEV KwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-8207 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 34 sections