insulin lispro 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
5002 133107-64-9

Description:

MoleculeDescription

Synonyms:

  • insulin lispro BS
  • lyumjev
  • insulin lispro protamine recombinant
  • insulin lispro protamine
  • insulin lispro
  • humalog
  • insulin lispro recombinant
  • humalog lispro
Insulin that has been modified so that the B-chain contains a LYSINE at position 28 instead of a PROLINE and a PROLINE at position 29 instead of a LYSINE. It is used to manage BLOOD GLUCOSE levels in patients with TYPE 2 DIABETES.
  • Molecular weight: 5807.63
  • Formula: C257H383N65O77S6
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 2299.07
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
40 U P
40 U P
40 U P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
March 25, 2020 PMDA Eli Lilly Japan K.K.
June 14, 1996 FDA LILLY
April 30, 1996 EMA Eli Lilly Nederland B.V.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood glucose increased 3224.38 10.88 1540 68855 93706 90464346
Hypoglycaemia 1619.83 10.88 876 69519 68972 90489080
Blood glucose decreased 733.55 10.88 360 70035 23069 90534983
Diabetic ketoacidosis 701.94 10.88 354 70041 24053 90533999
Diabetes mellitus inadequate control 593.56 10.88 290 70105 18394 90539658
Hyperglycaemia 477.24 10.88 361 70034 50609 90507443
Blood glucose abnormal 415.55 10.88 184 70211 9308 90548744
Glycosylated haemoglobin increased 407.63 10.88 212 70183 15350 90542702
Gangrene 379.65 10.88 190 70205 12686 90545366
Eye haemorrhage 378.18 10.88 176 70219 10004 90548048
Arterial occlusive disease 365.04 10.88 183 70212 12263 90545789
Blood glucose fluctuation 338.84 10.88 133 70262 4950 90553102
Neurologic neglect syndrome 313.34 10.88 148 70247 8699 90549353
Carotid artery thrombosis 312.54 10.88 149 70246 8943 90549109
Incorrect dose administered 299.15 10.88 337 70058 78593 90479459
Adjustment disorder 289.33 10.88 144 70251 9498 90548554
Personality disorder 276.61 10.88 152 70243 12292 90545760
Cataract 254.94 10.88 297 70098 71795 90486257
Sensory loss 248.40 10.88 162 70233 17913 90540139
Angina pectoris 245.97 10.88 220 70175 38940 90519112
Hemiplegia 239.78 10.88 152 70243 16008 90542044
Wrong product administered 234.51 10.88 116 70279 7549 90550503
Glossodynia 229.83 10.88 4 70391 321775 90236277
Motor dysfunction 227.41 10.88 157 70238 19073 90538979
Systemic lupus erythematosus 225.61 10.88 14 70381 361882 90196170
Affect lability 224.33 10.88 152 70243 17911 90540141
Skin haemorrhage 221.48 10.88 161 70234 21219 90536833
Coordination abnormal 210.35 10.88 156 70239 21200 90536852
Sinus congestion 204.55 10.88 170 70225 27254 90530798
Multi-organ disorder 202.83 10.88 73 70322 2127 90555925
Sneezing 197.94 10.88 173 70222 29696 90528356
Eating disorder 196.98 10.88 168 70227 27905 90530147
Cerebrovascular accident 194.17 10.88 346 70049 123187 90434865
Accidental underdose 183.76 10.88 57 70338 1034 90557018
Respiratory tract congestion 182.12 10.88 159 70236 27251 90530801
Hemiparesis 180.76 10.88 169 70226 31650 90526402
Pericarditis 172.78 10.88 9 70386 270142 90287910
Sinus disorder 171.24 10.88 170 70225 34277 90523775
Drug intolerance 169.26 10.88 68 70327 447523 90110529
Abdominal discomfort 167.15 10.88 81 70314 477247 90080805
Hypoglycaemic coma 163.98 10.88 68 70327 2922 90555130
Aphasia 162.49 10.88 183 70212 42629 90515423
Diabetic retinopathy 160.28 10.88 65 70330 2637 90555415
Synovitis 160.03 10.88 31 70364 329721 90228331
Joint swelling 157.96 10.88 98 70297 503202 90054850
Helicobacter infection 153.60 10.88 5 70390 226845 90331207
Infusion related reaction 153.25 10.88 66 70329 416714 90141338
Hepatic enzyme increased 151.47 10.88 46 70349 360690 90197362
Treatment failure 150.84 10.88 27 70368 303901 90254151
Cardiac failure congestive 150.67 10.88 273 70122 98421 90459631
Contraindicated product administered 147.34 10.88 34 70361 320105 90237947
Alopecia 145.11 10.88 104 70291 494967 90063085
Folliculitis 144.00 10.88 3 70392 204350 90353702
Ketoacidosis 143.00 10.88 75 70320 5520 90552532
Muscle spasticity 139.21 10.88 154 70241 35168 90522884
Product storage error 135.64 10.88 118 70277 20123 90537929
Arthropathy 133.02 10.88 59 70336 366183 90191869
Rhinorrhoea 131.89 10.88 242 70153 88074 90469978
Cystitis 131.67 10.88 207 70188 66511 90491541
Dysarthria 128.89 10.88 184 70211 54298 90503754
Therapeutic product effect decreased 126.68 10.88 30 70365 277541 90280511
Irritable bowel syndrome 120.77 10.88 11 70384 207437 90350615
Lower respiratory tract infection 118.59 10.88 25 70370 250634 90307418
Insulin resistance 116.51 10.88 41 70354 1117 90556935
Off label use 115.97 10.88 453 69942 1101799 89456253
Skin exfoliation 115.47 10.88 197 70198 67716 90490336
Discomfort 113.30 10.88 36 70359 274299 90283753
Rash 108.03 10.88 292 70103 795808 89762244
Eye discharge 103.74 10.88 70 70325 8188 90549864
Blindness 103.26 10.88 115 70280 26453 90531599
Acute kidney injury 102.42 10.88 506 69889 319881 90238171
Hypoglycaemic unconsciousness 102.12 10.88 34 70361 780 90557272
Thyroid disorder 102.04 10.88 95 70300 17690 90540362
Arthralgia 101.57 10.88 291 70104 778231 89779821
Swelling 100.92 10.88 106 70289 418952 90139100
Diabetic retinal oedema 96.87 10.88 28 70367 394 90557658
Blood pressure increased 93.49 10.88 351 70044 196866 90361186
Nasal obstruction 93.42 10.88 44 70351 2568 90555484
Stomatitis 92.47 10.88 49 70346 274649 90283403
Malnutrition 91.13 10.88 91 70304 18467 90539585
Psoriatic arthropathy 90.71 10.88 32 70363 228303 90329749
Musculoskeletal stiffness 88.49 10.88 61 70334 296471 90261581
Blister 88.04 10.88 44 70351 254954 90303098
Arthritis 87.09 10.88 307 70088 167008 90391044
Mobility decreased 86.97 10.88 43 70352 250691 90307361
Palpitations 84.61 10.88 266 70129 136462 90421590
Ill-defined disorder 84.29 10.88 20 70375 184871 90373181
Infective pulmonary exacerbation of cystic fibrosis 83.53 10.88 67 70328 10212 90547840
Product dispensing error 83.14 10.88 72 70323 12201 90545851
Fall 82.52 10.88 648 69747 481162 90076890
Influenza 81.69 10.88 266 70129 138998 90419054
Hypoglycaemic seizure 80.79 10.88 26 70369 534 90557518
Throat clearing 77.34 10.88 44 70351 3803 90554249
Wound 77.07 10.88 73 70322 302907 90255145
Liver injury 74.76 10.88 20 70375 170547 90387505
Influenza like illness 73.85 10.88 181 70214 80430 90477622
Hypoglycaemia unawareness 70.78 10.88 17 70378 109 90557943
Bursitis 69.07 10.88 10 70385 131644 90426408
Dysphagia 69.06 10.88 218 70177 112060 90445992
Visual acuity reduced 68.98 10.88 88 70307 23322 90534730
Product complaint 67.77 10.88 67 70328 13433 90544619
Pulmonary oedema 67.39 10.88 149 70246 61931 90496121
Blood cholesterol increased 67.25 10.88 39 70356 207973 90350079
Insulin C-peptide decreased 66.64 10.88 14 70381 43 90558009
Fibromyalgia 66.22 10.88 39 70356 206230 90351822
C-reactive protein abnormal 66.11 10.88 10 70385 127419 90430633
Product dose omission issue 65.45 10.88 419 69976 291268 90266784
Joint range of motion decreased 65.22 10.88 13 70382 135630 90422422
Intercepted product selection error 64.67 10.88 12 70383 14 90558038
Chest discomfort 64.49 10.88 245 70150 138120 90419932
Type 2 diabetes mellitus 63.05 10.88 40 70355 203204 90354848
Impaired healing 62.44 10.88 54 70341 234145 90323907
Renal failure 61.91 10.88 233 70162 130774 90427278
Increased insulin requirement 60.42 10.88 14 70381 75 90557977
Diabetic neuropathy 60.41 10.88 40 70355 4534 90553518
Expired product administered 60.29 10.88 47 70348 6875 90551177
Lip dry 59.69 10.88 5 70390 100950 90457102
Injury associated with device 56.46 10.88 38 70357 4426 90553626
Product administration error 54.93 10.88 84 70311 26339 90531713
Underdose 54.56 10.88 126 70269 53891 90504161
Hypersensitivity 54.12 10.88 177 70218 454500 90103552
Loss of consciousness 53.96 10.88 234 70161 140004 90418048
Dry mouth 52.09 10.88 40 70355 184019 90374033
Intentional product use issue 51.99 10.88 55 70340 216837 90341215
Blood insulin increased 51.76 10.88 14 70381 152 90557900
Type 1 diabetes mellitus 51.57 10.88 37 70358 4775 90553277
Anti-insulin antibody increased 50.93 10.88 11 70384 40 90558012
Neuropathy peripheral 50.01 10.88 225 70170 136745 90421307
Sleep disorder 48.84 10.88 49 70346 197981 90360071
Injury 48.48 10.88 49 70346 197300 90360752
Product use issue 47.67 10.88 117 70278 329802 90228250
Intercepted product dispensing error 47.66 10.88 13 70382 146 90557906
Anti-insulin antibody positive 47.00 10.88 12 70383 102 90557950
Drug hypersensitivity 45.69 10.88 195 70200 463414 90094638
Pericardial effusion 45.27 10.88 93 70302 36740 90521312
Pre-eclampsia 44.96 10.88 49 70346 10999 90547053
Pulmonary fibrosis 44.54 10.88 14 70381 107489 90450563
Toxicity to various agents 44.04 10.88 99 70296 287747 90270305
Prescribed overdose 43.62 10.88 11 70384 97614 90460438
Product use in unapproved indication 43.46 10.88 126 70269 336110 90221942
Night sweats 43.25 10.88 23 70372 128743 90429309
Diabetic foot 42.07 10.88 22 70373 1609 90556443
Inflammation 42.01 10.88 46 70349 178546 90379506
Hypoaesthesia 41.15 10.88 117 70278 314093 90243959
Diabetes mellitus 40.83 10.88 127 70268 64748 90493304
Peripheral swelling 40.54 10.88 174 70221 412932 90145120
Hypoglycaemia neonatal 40.43 10.88 19 70376 1103 90556949
Peripheral venous disease 40.43 10.88 8 70387 83913 90474139
Insomnia 40.22 10.88 129 70266 333345 90224707
Hip arthroplasty 39.48 10.88 6 70389 76202 90481850
Eye pruritus 38.92 10.88 76 70319 28951 90529101
Wound infection 38.79 10.88 17 70378 106385 90451667
Visual impairment 38.67 10.88 204 70191 132161 90425891
Grip strength decreased 38.45 10.88 12 70383 92564 90465488
Secretion discharge 38.04 10.88 54 70341 15842 90542210
Pseudomonal bacteraemia 37.93 10.88 22 70373 1972 90556080
Migraine 37.57 10.88 56 70339 190336 90367716
Anti-insulin antibody 37.50 10.88 8 70387 27 90558025
Drug ineffective 37.46 10.88 806 69589 1383492 89174560
Shock hypoglycaemic 37.02 10.88 10 70385 108 90557944
Myocardial infarction 36.39 10.88 171 70224 105801 90452251
Large for dates baby 36.07 10.88 14 70381 505 90557547
Hyperkalaemia 35.32 10.88 121 70274 64843 90493209
Scleroedema 35.32 10.88 10 70385 130 90557922
Wrong technique in product usage process 35.22 10.88 129 70266 71442 90486610
C-reactive protein increased 35.16 10.88 54 70341 181335 90376717
Insulinoma 35.11 10.88 10 70385 133 90557919
Knee arthroplasty 34.16 10.88 11 70384 83171 90474881
Red blood cell sedimentation rate increased 33.78 10.88 11 70384 82584 90475468
Lung disorder 33.73 10.88 40 70355 149843 90408209
Dyspnoea exertional 33.66 10.88 128 70267 72160 90485892
Contusion 33.29 10.88 93 70302 251123 90306929
Gait inability 33.05 10.88 39 70356 146417 90411635
Transcription medication error 32.89 10.88 11 70384 256 90557796
Infection 32.83 10.88 157 70238 361937 90196115
Chronic kidney disease 32.27 10.88 99 70296 50092 90507960
Autoimmune disorder 31.78 10.88 10 70385 76734 90481318
Nausea 31.72 10.88 1105 69290 1109211 89448841
Sciatica 31.36 10.88 20 70375 101362 90456690
Hypercholesterolaemia 31.08 10.88 20 70375 100872 90457180
Acute respiratory failure 30.78 10.88 88 70307 42830 90515222
Diabetic complication 30.58 10.88 15 70380 958 90557094
Transient tachypnoea of the newborn 30.54 10.88 9 70386 136 90557916
Pancreatic carcinoma 30.40 10.88 35 70360 8342 90549710
Coronary artery disease 30.25 10.88 75 70320 33548 90524504
Sopor 30.02 10.88 62 70333 24582 90533470
Diabetic nephropathy 30.02 10.88 18 70377 1716 90556336
Endometrial disorder 29.88 10.88 14 70381 807 90557245
Psoriasis 29.33 10.88 206 70189 147548 90410504
Adverse drug reaction 28.62 10.88 29 70366 116672 90441380
Myelosuppression 28.27 10.88 4 70391 53587 90504465
Nail disorder 27.69 10.88 6 70389 59061 90498991
Lupus-like syndrome 27.34 10.88 3 70392 48843 90509209
Premature delivery 27.33 10.88 79 70316 38683 90519369
Ischaemic stroke 27.28 10.88 56 70339 22110 90535942
Epilepsy 27.14 10.88 15 70380 82191 90475861
Intensive care unit acquired weakness 27.12 10.88 14 70381 997 90557055
Sepsis 27.01 10.88 235 70160 179579 90378473
Renal tubular disorder 26.26 10.88 21 70374 3186 90554866
Keratitis 26.12 10.88 23 70372 3983 90554069
Euglycaemic diabetic ketoacidosis 26.10 10.88 28 70367 6173 90551879
Croup infectious 25.89 10.88 12 70383 675 90557377
Urinary tract infection 25.75 10.88 356 70039 305276 90252776
Urinary tract obstruction 25.73 10.88 18 70377 2231 90555821
Ventricular septal defect 25.60 10.88 26 70369 5381 90552671
Rhonchi 25.46 10.88 20 70375 2958 90555094
Vitreous haemorrhage 25.44 10.88 19 70376 2607 90555445
Epileptic encephalopathy 25.30 10.88 10 70385 379 90557673
Diabetic coma 25.01 10.88 12 70383 730 90557322
Cutaneous amyloidosis 24.70 10.88 5 70390 12 90558040
Chronic obstructive pulmonary disease 24.52 10.88 118 70277 73711 90484341
Device operational issue 24.29 10.88 13 70382 997 90557055
Urticaria 24.22 10.88 143 70252 312591 90245461
Dopamine transporter scintigraphy abnormal 24.18 10.88 7 70388 99 90557953
Cellulitis 24.13 10.88 137 70258 91200 90466852
Live birth 23.93 10.88 16 70379 79091 90478961
Disease progression 23.83 10.88 54 70341 156561 90401491
Bone erosion 23.64 10.88 6 70389 53015 90505037
Anaemia 23.56 10.88 395 70000 352407 90205645
Enterococcus test positive 23.54 10.88 14 70381 1315 90556737
Lower limb fracture 23.38 10.88 19 70376 84994 90473058
Joint stiffness 23.32 10.88 16 70379 78026 90480026
Generalised oedema 23.29 10.88 48 70347 19005 90539047
Medical device site abscess 23.27 10.88 8 70387 203 90557849
Dyspepsia 22.94 10.88 78 70317 198082 90359970
Medical device site cellulitis 22.73 10.88 8 70387 218 90557834
Pertussis 22.73 10.88 12 70383 895 90557157
Cystic fibrosis 22.50 10.88 21 70374 3920 90554132
Blood ketone body increased 22.50 10.88 9 70386 352 90557700
Infusion site pain 22.12 10.88 48 70347 19690 90538362
Hyperinsulinaemic hypoglycaemia 22.12 10.88 7 70388 136 90557916
Renal impairment 22.11 10.88 149 70246 105272 90452780
Neck pain 22.01 10.88 34 70361 113929 90444123
Non-cardiogenic pulmonary oedema 21.95 10.88 13 70382 1211 90556841
Dehydration 21.78 10.88 239 70156 194208 90363844
Small for dates baby 21.77 10.88 23 70372 4984 90553068
Patella fracture 21.57 10.88 17 70378 2526 90555526
Malignant neoplasm progression 21.50 10.88 31 70364 106839 90451213
Blood ketone body 21.34 10.88 6 70389 76 90557976
Treatment noncompliance 21.19 10.88 88 70307 51639 90506413
Congestive hepatopathy 20.96 10.88 18 70377 3015 90555037
Osteoarthritis 20.70 10.88 80 70315 195650 90362402
Retinopathy 20.51 10.88 19 70376 3515 90554537
Diabetic hyperglycaemic coma 20.31 10.88 5 70390 36 90558016
Exostosis 20.15 10.88 8 70387 53126 90504926
Therapeutic product effect incomplete 20.03 10.88 80 70315 193816 90364236
Foetal exposure during pregnancy 19.92 10.88 76 70319 42899 90515153
Condition aggravated 19.92 10.88 334 70061 595211 89962841
Paraesthesia 19.62 10.88 114 70281 250212 90307840
Asthenia 19.60 10.88 548 69847 533203 90024849
Peritonitis bacterial 19.43 10.88 22 70373 5149 90552903
Antibody test negative 19.43 10.88 5 70390 44 90558008
Urine ketone body present 19.40 10.88 16 70379 2536 90555516
Cough 19.38 10.88 398 69997 368564 90189488
Electrolyte imbalance 19.32 10.88 51 70344 23694 90534358
Pancreatic disorder 19.26 10.88 17 70378 2954 90555098
Onychomycosis 19.23 10.88 3 70392 37373 90520679
Vomiting 19.17 10.88 771 69624 787522 89770530
Prescribed underdose 19.14 10.88 18 70377 75001 90483051
Laryngitis 18.67 10.88 8 70387 50745 90507307
Rubella antibody negative 18.48 10.88 3 70392 0 90558052
Neuropathic arthropathy 18.41 10.88 8 70387 386 90557666
Drug-induced liver injury 18.36 10.88 26 70369 90292 90467760
Adverse event 18.25 10.88 40 70355 117378 90440674
Obesity 18.06 10.88 34 70361 105473 90452579
Hypoacusis 17.96 10.88 55 70340 27795 90530257
Impaired gastric emptying 17.74 10.88 34 70361 12775 90545277
Fasting 17.66 10.88 4 70391 19 90558033
Renal disorder 17.59 10.88 67 70328 37792 90520260
Anxiety 17.55 10.88 338 70057 309434 90248618
Obstructive airways disorder 17.55 10.88 52 70343 25817 90532235
Completed suicide 17.54 10.88 56 70339 145002 90413050
Caesarean section 17.31 10.88 42 70353 18535 90539517
Muscle spasms 17.03 10.88 120 70275 251763 90306289
Exposure via eye contact 17.03 10.88 4 70391 23 90558029
Wrong patient received product 16.98 10.88 17 70378 3460 90554592
Gestational hypertension 16.88 10.88 16 70379 3046 90555006
Intercepted product prescribing error 16.87 10.88 7 70388 301 90557751
Loss of personal independence in daily activities 16.84 10.88 52 70343 136053 90421999
Delirium 16.68 10.88 35 70360 104324 90453728
Blindness unilateral 16.65 10.88 25 70370 7711 90550341
Blindness transient 16.52 10.88 19 70376 4524 90553528
Eye irritation 16.51 10.88 61 70334 33917 90524135
Road traffic accident 16.46 10.88 37 70358 107589 90450463
Pruritus 16.42 10.88 309 70086 541216 90016836
Therapy non-responder 16.38 10.88 53 70342 136651 90421401
Dermatitis bullous 16.32 10.88 29 70366 10287 90547765
Lactic acidosis 16.28 10.88 80 70315 50383 90507669
Localised infection 16.09 10.88 60 70335 33502 90524550
End stage renal disease 16.08 10.88 26 70369 8545 90549507
Dawn phenomenon 15.95 10.88 3 70392 4 90558048
Peripheral sensorimotor neuropathy 15.92 10.88 13 70382 2032 90556020
Mitral valve stenosis 15.84 10.88 11 70384 1348 90556704
Drug tolerance decreased 15.61 10.88 3 70392 32127 90525925
Ketosis 15.59 10.88 9 70386 800 90557252
Chest pain 15.55 10.88 341 70054 319304 90238748
Frequent bowel movements 15.32 10.88 13 70382 56922 90501130
Exposure during pregnancy 15.20 10.88 265 70130 238145 90319907
Foetal hypokinesia 14.88 10.88 8 70387 619 90557433
Cardiac hypertrophy 14.83 10.88 10 70385 1168 90556884
Type III immune complex mediated reaction 14.74 10.88 7 70388 416 90557636
Myalgia 14.73 10.88 204 70191 174921 90383131
Vascular parkinsonism 14.73 10.88 5 70390 122 90557930
Urosepsis 14.71 10.88 43 70352 21189 90536863
Back injury 14.69 10.88 9 70386 46613 90511439
Pallor 14.69 10.88 59 70336 34106 90523946
Pyelonephritis 14.60 10.88 43 70352 21273 90536779
Hospitalisation 14.59 10.88 158 70237 127942 90430110
Product prescribing error 14.55 10.88 54 70341 30091 90527961
Glomerular filtration rate decreased 14.43 10.88 37 70358 16895 90541157
Hypervolaemia 14.43 10.88 57 70338 32700 90525352
Muscular weakness 14.38 10.88 233 70162 206433 90351619
Diabetic metabolic decompensation 14.32 10.88 12 70383 1945 90556107
Device expulsion 14.18 10.88 7 70388 40879 90517173
Cardiac disorder 14.17 10.88 84 70311 56788 90501264
Pneumonia 14.11 10.88 618 69777 637441 89920611
Arteriosclerosis 14.04 10.88 28 70367 10825 90547227
Pain 14.03 10.88 632 69763 995709 89562343
Rectal haemorrhage 13.86 10.88 27 70368 82717 90475335
Hepatitis 13.76 10.88 21 70374 70718 90487334
Incorrect product dosage form administered 13.66 10.88 5 70390 153 90557899
Gastrointestinal haemorrhage 13.57 10.88 118 70277 90130 90467922
Inflammatory marker increased 13.43 10.88 25 70370 9189 90548863
Musculoskeletal pain 13.41 10.88 78 70317 171173 90386879
Nerve compression 13.36 10.88 27 70368 10539 90547513
Poor quality product administered 13.31 10.88 16 70379 3992 90554060
Anuria 13.27 10.88 33 70362 14785 90543267
White blood cell count decreased 13.14 10.88 76 70319 167033 90391019
Liver function test increased 13.11 10.88 29 70366 84826 90473226
Thyroid cancer 13.09 10.88 20 70375 6264 90551788
Listeraemia 12.98 10.88 4 70391 71 90557981
Cardiac death 12.56 10.88 7 70388 581 90557471
Full blood count abnormal 12.52 10.88 59 70336 36538 90521514
Adenocarcinoma pancreas 12.50 10.88 9 70386 1167 90556885
Blood potassium increased 12.48 10.88 40 70355 20709 90537343
Flank pain 12.43 10.88 38 70357 19184 90538868
Depression 12.31 10.88 162 70233 300439 90257613
Hypertriglyceridaemia 12.25 10.88 22 70373 7867 90550185
Wheezing 12.21 10.88 122 70273 237958 90320094
Coronary artery occlusion 12.21 10.88 23 70372 8531 90549521
Syncope 12.18 10.88 157 70238 132506 90425546
Premature baby 12.16 10.88 45 70350 25032 90533020
Injection site pain 12.14 10.88 196 70199 173503 90384549
Anaemia of malignant disease 12.07 10.88 7 70388 627 90557425
Radiation overdose 11.91 10.88 3 70392 24 90558028
Tachypnoea 11.85 10.88 40 70355 21269 90536783
Myelopathy 11.85 10.88 14 70381 3430 90554622
Gastroschisis 11.83 10.88 6 70389 412 90557640
Toe amputation 11.77 10.88 11 70384 2058 90555994
Polyhydramnios 11.77 10.88 12 70383 2496 90555556
Amnesia 11.69 10.88 44 70351 108461 90449591
Micturition disorder 11.61 10.88 13 70382 3007 90555045
Maternal drugs affecting foetus 11.59 10.88 17 70378 5138 90552914
Taste disorder 11.28 10.88 19 70376 61527 90496525
Heart rate decreased 11.28 10.88 15 70380 53490 90504562
Amputation 11.18 10.88 5 70390 259 90557793
Pancreatic cyst 11.15 10.88 11 70384 2199 90555853
Mental status changes 11.14 10.88 66 70329 44613 90513439
Food allergy 11.13 10.88 3 70392 25475 90532577
Polydipsia 11.06 10.88 15 70380 4216 90553836
Clostridium test positive 10.98 10.88 17 70378 5384 90552668
Ascites 10.94 10.88 69 70326 47671 90510381
Postprandial hypoglycaemia 10.91 10.88 4 70391 123 90557929
Malaise 10.91 10.88 558 69837 585428 89972624

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood glucose increased 2107.58 10.97 1219 48714 72480 42498922
Hypoglycaemia 1334.47 10.97 845 49088 59009 42512393
Blood glucose decreased 479.95 10.97 263 49670 13956 42557446
Diabetic ketoacidosis 412.51 10.97 281 49652 22086 42549316
Hyperglycaemia 404.51 10.97 373 49560 45486 42525916
Diabetes mellitus inadequate control 389.45 10.97 236 49697 15154 42556248
Blood glucose abnormal 331.56 10.97 163 49770 6890 42564512
Glycosylated haemoglobin increased 316.25 10.97 194 49739 12730 42558672
Incorrect dose administered 229.03 10.97 296 49637 52678 42518724
Hypoglycaemic coma 180.42 10.97 80 49853 2664 42568738
Wrong product administered 177.10 10.97 103 49830 6123 42565279
Hypoglycaemic unconsciousness 166.94 10.97 54 49879 730 42570672
Blood glucose fluctuation 144.18 10.97 81 49852 4506 42566896
Accidental underdose 133.90 10.97 44 49889 627 42570775
Anti-insulin antibody positive 132.72 10.97 33 49900 154 42571248
Toxicity to various agents 122.02 10.97 58 49875 229078 42342324
Product storage error 114.72 10.97 99 49834 11041 42560361
Off label use 97.52 10.97 402 49531 637933 41933469
Diabetic retinopathy 94.92 10.97 47 49886 2016 42569386
Intercepted product selection error 86.00 10.97 17 49916 17 42571385
Ketoacidosis 84.08 10.97 61 49872 5291 42566111
Underdose 78.08 10.97 97 49836 16569 42554833
Hypoglycaemic seizure 70.88 10.97 24 49909 377 42571025
Diabetic metabolic decompensation 65.73 10.97 37 49896 2065 42569337
Product dispensing error 59.37 10.97 58 49875 7581 42563821
Drug abuse 58.06 10.97 25 49908 104746 42466656
Foetal disorder 56.93 10.97 27 49906 1052 42570350
Hypoglycaemia unawareness 55.74 10.97 16 49917 140 42571262
Acute kidney injury 55.31 10.97 665 49268 366672 42204730
Insulin resistance 54.40 10.97 24 49909 789 42570613
Diabetic neuropathy 52.52 10.97 43 49890 4459 42566943
Infusion site pain 51.64 10.97 46 49887 5349 42566053
Product complaint 47.61 10.97 46 49887 5931 42565471
Infective pulmonary exacerbation of cystic fibrosis 47.48 10.97 52 49881 7766 42563636
Neutropenia neonatal 45.44 10.97 22 49911 898 42570504
Blindness 43.91 10.97 77 49856 17901 42553501
Cutaneous amyloidosis 41.87 10.97 10 49923 38 42571364
Anti-insulin antibody increased 41.65 10.97 11 49922 68 42571334
Anti-insulin antibody 39.07 10.97 9 49924 28 42571374
Intercepted product dispensing error 37.85 10.97 11 49922 101 42571301
Visual impairment 37.04 10.97 123 49810 42990 42528412
Hyperkalaemia 36.14 10.97 188 49745 80270 42491132
Wrong technique in product usage process 36.06 10.97 121 49812 42514 42528888
Completed suicide 35.89 10.97 36 49897 96429 42474973
Impaired gastric emptying 35.53 10.97 34 49899 4332 42567070
Pancreatic carcinoma 34.75 10.97 49 49884 9457 42561945
Product use in unapproved indication 34.72 10.97 106 49827 184350 42387052
Retinopathy 33.58 10.97 25 49908 2256 42569146
Dehydration 32.98 10.97 281 49652 141486 42429916
Diabetic coma 32.33 10.97 18 49915 983 42570419
Ketosis 31.23 10.97 17 49916 888 42570514
Myelosuppression 31.17 10.97 5 49928 40456 42530946
Cardiac failure congestive 31.14 10.97 189 49744 85413 42485989
Product dose omission issue 30.82 10.97 296 49637 154069 42417333
Type 1 diabetes mellitus 30.75 10.97 35 49898 5452 42565950
Systemic infection 30.53 10.97 34 49899 5171 42566231
Disease progression 30.40 10.97 78 49855 143578 42427824
Left atrial dilatation 30.26 10.97 24 49909 2378 42569024
Sopor 30.26 10.97 55 49878 13147 42558255
Treatment failure 30.11 10.97 18 49915 62606 42508796
Toe amputation 30.09 10.97 26 49907 2903 42568499
Febrile neutropenia 29.99 10.97 114 49819 185589 42385813
Diabetic foot 29.01 10.97 26 49907 3047 42568355
Diabetic foot infection 28.52 10.97 15 49918 731 42570671
Skin ulcer 28.50 10.97 80 49853 25521 42545881
Diabetic gastroparesis 28.43 10.97 9 49924 113 42571289
Multiple organ dysfunction syndrome 27.97 10.97 44 49889 96991 42474411
Increased insulin requirement 27.09 10.97 9 49924 133 42571269
Haematocrit increased 26.80 10.97 23 49910 2544 42568858
Shock hypoglycaemic 26.74 10.97 8 49925 82 42571320
Hypoaldosteronism 26.48 10.97 11 49922 311 42571091
Diaphragmatic disorder 26.28 10.97 17 49916 1222 42570180
Mucosal dryness 26.07 10.97 19 49914 1659 42569743
Visual acuity reduced 25.91 10.97 61 49872 17489 42553913
Expired product administered 25.82 10.97 28 49905 4135 42567267
Oedematous pancreatitis 25.45 10.97 14 49919 747 42570655
Loss of consciousness 24.69 10.97 189 49744 92165 42479237
Product monitoring error 24.43 10.97 28 49905 4395 42567007
Insulin autoimmune syndrome 24.10 10.97 12 49921 521 42570881
Drug ineffective for unapproved indication 24.03 10.97 12 49921 46151 42525251
Medication error 23.66 10.97 89 49844 33065 42538337
Cerebrovascular accident 23.33 10.97 194 49739 96966 42474436
Mumps antibody test negative 23.00 10.97 4 49929 0 42571402
Meningomyelocele 22.85 10.97 9 49924 221 42571181
Premature baby 22.57 10.97 69 49864 23084 42548318
Diabetic nephropathy 22.48 10.97 20 49913 2321 42569081
Leg amputation 22.44 10.97 21 49912 2602 42568800
Haemoglobin increased 22.32 10.97 29 49904 5177 42566225
Oedema peripheral 21.98 10.97 250 49683 135826 42435576
Amylase decreased 21.96 10.97 7 49926 90 42571312
Acetonaemia 21.75 10.97 9 49924 252 42571150
Road traffic accident 21.58 10.97 60 49873 19033 42552369
Device operational issue 21.48 10.97 9 49924 260 42571142
Congenital multiplex arthrogryposis 21.36 10.97 9 49924 264 42571138
Mucosal inflammation 21.30 10.97 16 49917 49358 42522044
Pseudolymphoma 21.26 10.97 12 49921 673 42570729
Localised infection 21.07 10.97 62 49871 20311 42551091
Drug resistance 20.91 10.97 7 49926 34241 42537161
VACTERL syndrome 20.85 10.97 6 49927 53 42571349
Renal disorder 20.85 10.97 78 49855 28902 42542500
Infusion site induration 20.68 10.97 10 49923 407 42570995
Fall 20.11 10.97 386 49547 234134 42337268
Hypoglycaemic encephalopathy 19.93 10.97 9 49924 313 42571089
Cold sweat 19.66 10.97 42 49891 11288 42560114
Neutropenia 19.55 10.97 145 49788 199286 42372116
Osteomyelitis 19.36 10.97 56 49877 18167 42553235
Hospitalisation 19.24 10.97 151 49782 74179 42497223
Loss of personal independence in daily activities 19.21 10.97 18 49915 49798 42521604
Malignant neoplasm progression 19.18 10.97 64 49869 108336 42463066
Sedation 19.01 10.97 6 49927 30469 42540933
Acute respiratory failure 18.98 10.97 93 49840 38765 42532637
Intentional product use issue 18.47 10.97 35 49898 71798 42499604
Immunosuppressant drug level decreased 18.35 10.97 16 49917 1808 42569594
Weight increased 18.17 10.97 200 49733 107783 42463619
Hypervolaemia 18.12 10.97 64 49869 23061 42548341
Somnolence 17.74 10.97 95 49838 141010 42430392
Chronic kidney disease 17.61 10.97 105 49828 47136 42524266
Peritonitis bacterial 17.38 10.97 30 49903 6885 42564517
Measles antibody negative 17.25 10.97 3 49930 0 42571402
Rubella antibody negative 17.25 10.97 3 49930 0 42571402
Rash 17.20 10.97 225 49708 276729 42294673
Poor quality product administered 16.96 10.97 17 49916 2291 42569111
Lower respiratory tract infection 16.96 10.97 14 49919 41192 42530210
Cellulitis 16.43 10.97 126 49807 61459 42509943
Blood ketone body 16.24 10.97 6 49927 123 42571279
Pulmonary embolism 15.89 10.97 79 49854 119533 42451869
Balanoposthitis 15.87 10.97 14 49919 1607 42569795
Pseudohyponatraemia 15.80 10.97 6 49927 133 42571269
Intraventricular haemorrhage 15.67 10.97 21 49912 3863 42567539
Injury associated with device 15.58 10.97 13 49920 1384 42570018
Hemivertebra 15.48 10.97 6 49927 141 42571261
Joint swelling 15.10 10.97 36 49897 67986 42503416
Musculoskeletal stiffness 14.98 10.97 28 49905 57737 42513665
Diabetic wound 14.92 10.97 5 49928 76 42571326
Drug intolerance 14.56 10.97 47 49886 80377 42491025
Cytomegalovirus infection 14.55 10.97 10 49923 32296 42539106
Liquid product physical issue 14.51 10.97 10 49923 799 42570603
Syncope 14.44 10.97 179 49754 99227 42472175
Agitation 14.31 10.97 34 49899 64280 42507122
Therapy partial responder 14.29 10.97 3 49930 20018 42551384
Product name confusion 14.24 10.97 5 49928 88 42571314
Lipohypertrophy 14.23 10.97 7 49926 296 42571106
Injection site nodule 14.22 10.97 15 49918 2146 42569256
Atrial fibrillation 14.15 10.97 236 49697 139357 42432045
Arthralgia 14.14 10.97 163 49770 205075 42366327
Foot amputation 13.99 10.97 10 49923 847 42570555
Microalbuminuria 13.81 10.97 10 49923 864 42570538
Varices oesophageal 13.78 10.97 21 49912 4344 42567058
Neutrophil count decreased 13.73 10.97 34 49899 63381 42508021
Insulin C-peptide increased 13.60 10.97 5 49928 101 42571301
Insulin C-peptide decreased 13.46 10.97 4 49929 40 42571362
Cataract 13.38 10.97 71 49862 30533 42540869
Meningitis aseptic 13.36 10.97 21 49912 4461 42566941
Hepatic encephalopathy 13.31 10.97 46 49887 16396 42555006
Respiratory depression 13.12 10.97 3 49930 18865 42552537
Post streptococcal glomerulonephritis 13.04 10.97 5 49928 114 42571288
Treatment noncompliance 12.95 10.97 82 49851 37590 42533812
Incorrect product formulation administered 12.72 10.97 4 49929 49 42571353
Presyncope 12.72 10.97 56 49877 22331 42549071
Erythema 12.71 10.97 75 49858 108718 42462684
Diabetic complication 12.66 10.97 9 49924 756 42570646
Glycogen storage disease type VIII 12.44 10.97 3 49930 12 42571390
Impaired insulin secretion 12.44 10.97 3 49930 12 42571390
Condition aggravated 12.37 10.97 223 49710 260531 42310871
Diabetes mellitus 12.35 10.97 116 49817 59971 42511431
Pyrexia 12.22 10.97 360 49573 393682 42177720
Eye haemorrhage 12.20 10.97 21 49912 4809 42566593
Trigger finger 12.17 10.97 10 49923 1042 42570360
Lymphopenia 12.17 10.97 5 49928 21558 42549844
Subarachnoid haemorrhage 12.17 10.97 41 49892 14431 42556971
Oedematous kidney 12.04 10.97 4 49929 59 42571343
Psychotic disorder 11.92 10.97 10 49923 29198 42542204
Sleep disorder 11.87 10.97 24 49909 48071 42523331
Blindness unilateral 11.78 10.97 22 49911 5366 42566036
Stomatitis 11.69 10.97 26 49907 50303 42521099
Retrognathia 11.65 10.97 6 49927 280 42571122
Serotonin syndrome 11.64 10.97 8 49925 25837 42545565
Epididymitis 11.63 10.97 16 49917 3018 42568384
C-reactive protein increased 11.60 10.97 37 49896 63523 42507879
Injection site pain 11.59 10.97 111 49822 57687 42513715
Malaise 11.59 10.97 328 49605 211828 42359574
Bone marrow failure 11.57 10.97 13 49920 33080 42538322
Pancreatitis acute 11.50 10.97 73 49860 33491 42537911
Clostridium test positive 11.45 10.97 22 49911 5483 42565919
Cystic fibrosis 11.33 10.97 13 49920 2042 42569360
Hydrops foetalis 11.31 10.97 9 49924 896 42570506
Vitreous haemorrhage 11.31 10.97 15 49918 2732 42568670
Blood ketone body present 11.21 10.97 4 49929 74 42571328
Pancreatic carcinoma metastatic 11.10 10.97 16 49917 3150 42568252
Impaired fasting glucose 11.00 10.97 6 49927 315 42571087
Extra dose administered 10.99 10.97 22 49911 5647 42565755

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 2551.63 10.54 1466 95785 114638 110377410
Blood glucose increased 2487.52 10.54 1511 95740 130985 110361063
Diabetic ketoacidosis 811.56 10.54 489 96762 41569 110450479
Diabetes mellitus inadequate control 753.14 10.54 413 96838 29362 110462686
Blood glucose decreased 704.66 10.54 394 96857 29094 110462954
Hyperglycaemia 704.51 10.54 590 96661 84500 110407548
Glycosylated haemoglobin increased 461.68 10.54 277 96974 23342 110468706
Gangrene 351.76 10.54 204 97047 16137 110475911
Arterial occlusive disease 321.30 10.54 188 97063 15120 110476928
Blood glucose fluctuation 303.13 10.54 144 97107 7554 110484494
Carotid artery thrombosis 298.25 10.54 153 97098 9485 110482563
Neurologic neglect syndrome 297.60 10.54 151 97100 9147 110482901
Blood glucose abnormal 296.08 10.54 168 97083 12748 110479300
Hypoglycaemic coma 285.70 10.54 125 97126 5408 110486640
Adjustment disorder 270.85 10.54 149 97102 10646 110481402
Personality disorder 265.06 10.54 156 97095 12681 110479367
Sensory loss 216.12 10.54 167 97084 21290 110470758
Hemiplegia 211.53 10.54 169 97082 22613 110469435
Affect lability 209.74 10.54 155 97096 18482 110473566
Skin haemorrhage 207.04 10.54 173 97078 24654 110467394
Angina pectoris 203.03 10.54 262 96989 62033 110430015
Ketoacidosis 186.02 10.54 114 97137 9973 110482075
Acute kidney injury 184.60 10.54 1069 96182 634361 109857687
Systemic lupus erythematosus 182.82 10.54 10 97241 254328 110237720
Eye haemorrhage 181.98 10.54 119 97132 11655 110480393
Motor dysfunction 180.97 10.54 159 97092 24247 110467801
Sneezing 180.52 10.54 179 97072 31805 110460243
Sinus congestion 180.36 10.54 175 97076 30284 110461764
Cataract 177.31 10.54 279 96972 79206 110412842
Coordination abnormal 176.43 10.54 159 97092 25069 110466979
Eating disorder 174.72 10.54 173 97078 30685 110461363
Glossodynia 172.09 10.54 5 97246 221999 110270049
Multi-organ disorder 170.09 10.54 75 97176 3306 110488742
Wrong product administered 167.51 10.54 110 97141 10850 110481198
Off label use 164.50 10.54 721 96530 1499464 108992584
Sinus disorder 164.39 10.54 172 97079 32556 110459492
Anti-insulin antibody positive 162.34 10.54 40 97211 251 110491797
Respiratory tract congestion 161.89 10.54 166 97085 30691 110461357
Drug intolerance 159.62 10.54 79 97172 406433 110085615
Hypoglycaemic unconsciousness 154.79 10.54 53 97198 1167 110490881
Cardiac failure congestive 152.64 10.54 380 96871 150620 110341428
Cerebrovascular accident 149.56 10.54 423 96828 180861 110311187
Pericarditis 144.80 10.54 13 97238 219101 110272947
Synovitis 142.64 10.54 33 97218 274059 110217989
Hemiparesis 138.91 10.54 182 97069 43721 110448327
Helicobacter infection 137.74 10.54 5 97246 181872 110310176
Treatment failure 135.38 10.54 38 97213 277196 110214852
Toxicity to various agents 135.12 10.54 134 97117 480421 110011627
Joint swelling 134.55 10.54 115 97136 442730 110049318
Infusion related reaction 128.48 10.54 89 97162 381073 110110975
Accidental underdose 124.94 10.54 46 97205 1259 110490789
Muscle spasticity 124.83 10.54 156 97095 35759 110456289
Hypoglycaemic seizure 122.44 10.54 42 97209 930 110491118
Folliculitis 122.33 10.54 6 97245 167647 110324401
Product storage error 121.49 10.54 121 97130 21607 110470441
Aphasia 119.17 10.54 198 97053 58799 110433249
Lower respiratory tract infection 117.44 10.54 34 97217 243072 110248976
Insulin resistance 115.66 10.54 47 97204 1687 110490361
Alopecia 115.39 10.54 91 97160 364662 110127386
Therapeutic product effect decreased 114.70 10.54 36 97215 244280 110247768
Arthropathy 114.15 10.54 55 97196 287467 110204581
Incorrect dose administered 113.44 10.54 269 96982 103372 110388676
Muscle injury 109.74 10.54 3 97248 140804 110351244
Irritable bowel syndrome 107.80 10.54 10 97241 164205 110327843
Infective pulmonary exacerbation of cystic fibrosis 107.05 10.54 95 97156 14676 110477372
Abdominal discomfort 104.84 10.54 115 97136 393743 110098305
Diabetic retinopathy 102.87 10.54 54 97197 3510 110488538
Cystitis 99.38 10.54 195 97056 65841 110426207
Rash 98.03 10.54 381 96870 820583 109671465
Product complaint 97.57 10.54 88 97163 13884 110478164
Rhinorrhoea 94.02 10.54 249 97002 102417 110389631
Hepatic enzyme increased 93.02 10.54 87 97164 320805 110171243
Arthralgia 92.95 10.54 362 96889 779270 109712778
Dysarthria 90.61 10.54 217 97034 83904 110408144
Stomatitis 88.54 10.54 65 97186 270177 110221871
Anti-insulin antibody increased 85.50 10.54 20 97231 97 110491951
Thyroid disorder 84.89 10.54 89 97162 16880 110475168
Musculoskeletal stiffness 84.52 10.54 73 97178 279749 110212299
Ill-defined disorder 81.34 10.54 19 97232 156834 110335214
Nasal obstruction 80.64 10.54 45 97206 3305 110488743
Drug ineffective 79.84 10.54 905 96346 1519635 108972413
Fall 78.79 10.54 844 96407 602638 109889410
Hyperkalaemia 76.46 10.54 278 96973 135518 110356530
Psoriatic arthropathy 76.02 10.54 39 97212 196722 110295326
Swelling 75.50 10.54 120 97131 350921 110141127
Fibromyalgia 75.32 10.54 28 97223 170881 110321167
C-reactive protein abnormal 75.09 10.54 12 97239 129683 110362365
Skin exfoliation 74.66 10.54 207 97044 87444 110404604
Mobility decreased 74.08 10.54 60 97191 237362 110254686
Hypoglycaemia unawareness 73.68 10.54 21 97230 245 110491803
Bursitis 73.05 10.54 13 97238 129905 110362143
Loss of consciousness 73.02 10.54 354 96897 195952 110296096
Malnutrition 72.57 10.54 104 97147 27175 110464873
Lip dry 71.68 10.54 4 97247 100079 110391969
Throat clearing 67.46 10.54 44 97207 4289 110487759
Increased insulin requirement 67.43 10.54 19 97232 212 110491836
Blister 66.63 10.54 61 97190 227315 110264733
Blood cholesterol increased 66.50 10.54 40 97211 184745 110307303
Palpitations 64.99 10.54 295 96956 158917 110333131
Arthritis 64.34 10.54 305 96946 167281 110324767
Blood pressure increased 63.60 10.54 417 96834 257956 110234092
Hypersensitivity 63.15 10.54 166 97085 403832 110088216
Intentional product use issue 63.08 10.54 75 97176 247831 110244217
Cutaneous amyloidosis 63.07 10.54 14 97237 51 110491997
Product use in unapproved indication 62.46 10.54 194 97057 447183 110044865
Anti-insulin antibody 61.26 10.54 14 97237 60 110491988
Contraindicated product administered 61.18 10.54 77 97174 248190 110243858
Diabetic neuropathy 60.90 10.54 50 97201 6949 110485099
Joint range of motion decreased 60.76 10.54 16 97235 121816 110370232
Influenza like illness 60.30 10.54 193 97058 88219 110403829
Diabetic metabolic decompensation 59.35 10.54 39 97212 3850 110488198
Dehydration 58.72 10.54 434 96817 279077 110212971
Influenza 58.67 10.54 299 96952 168802 110323246
Acute respiratory failure 58.51 10.54 172 97079 75088 110416960
Insulin C-peptide decreased 57.07 10.54 14 97237 86 110491962
Blood insulin increased 56.87 10.54 19 97232 387 110491661
Sopor 56.29 10.54 109 97142 36437 110455611
Myelosuppression 56.28 10.54 8 97243 94332 110397716
Product administration error 56.11 10.54 110 97141 37107 110454941
Type 1 diabetes mellitus 55.48 10.54 53 97198 8994 110483054
Chest discomfort 54.56 10.54 299 96952 173549 110318499
Dysphagia 53.57 10.54 272 96979 153328 110338720
Expired product administered 53.42 10.54 50 97201 8270 110483778
Pancreatic carcinoma 52.32 10.54 65 97186 14807 110477241
Dry mouth 51.39 10.54 60 97191 199888 110292160
Red blood cell sedimentation rate increased 50.77 10.54 5 97246 78297 110413751
Diabetic foot 50.49 10.54 36 97215 4059 110487989
Sleep disorder 49.57 10.54 61 97190 198583 110293465
Wound 49.57 10.54 81 97170 234356 110257692
Completed suicide 49.17 10.54 86 97165 242295 110249753
Inflammation 48.58 10.54 59 97192 193179 110298869
Discomfort 48.44 10.54 71 97180 214636 110277412
Pulmonary oedema 46.80 10.54 194 97057 100465 110391583
Migraine 45.76 10.54 50 97201 171602 110320446
Impaired healing 45.41 10.54 64 97187 196653 110295395
Shock hypoglycaemic 44.65 10.54 14 97237 231 110491817
C-reactive protein increased 43.59 10.54 78 97173 217841 110274207
Hypoaesthesia 43.31 10.54 137 97114 314086 110177962
Liver injury 42.13 10.54 42 97209 150371 110341677
Peripheral venous disease 42.03 10.54 11 97240 84106 110407942
Type 2 diabetes mellitus 41.57 10.54 57 97194 177175 110314873
Drug hypersensitivity 41.48 10.54 232 97019 453858 110038190
Device operational issue 41.00 10.54 20 97231 1112 110490936
Grip strength decreased 40.99 10.54 10 97241 80164 110411884
Drug abuse 38.73 10.54 60 97191 177351 110314697
Insomnia 38.18 10.54 175 97076 360415 110131633
Ketosis 38.01 10.54 22 97229 1732 110490316
Systemic infection 37.93 10.54 45 97206 9774 110482274
Diabetic coma 37.42 10.54 20 97231 1348 110490700
Pre-eclampsia 37.38 10.54 42 97209 8608 110483440
Renal failure 37.37 10.54 333 96918 226241 110265807
No adverse event 37.26 10.54 146 97105 73693 110418355
Infection 37.04 10.54 178 97073 362022 110130026
Peritonitis bacterial 36.99 10.54 46 97205 10487 110481561
Sciatica 36.15 10.54 18 97233 92381 110399667
Autoimmune disorder 35.85 10.54 7 97244 65476 110426572
Asthenia 35.18 10.54 823 96428 688176 109803872
Hip arthroplasty 35.06 10.54 4 97247 55809 110436239
Product dose omission issue 34.71 10.54 434 96817 321348 110170700
Diabetic nephropathy 34.66 10.54 27 97224 3481 110488567
Hypervolaemia 34.66 10.54 109 97142 49351 110442697
Syncope 34.60 10.54 300 96951 202236 110289812
Cellulitis 34.47 10.54 209 97042 125807 110366241
Paraesthesia 34.40 10.54 126 97125 276395 110215653
Toe amputation 33.64 10.54 29 97222 4309 110487739
Euglycaemic diabetic ketoacidosis 33.42 10.54 46 97205 11577 110480471
Wound infection 33.16 10.54 22 97229 96443 110395605
Oedema peripheral 32.81 10.54 437 96814 328223 110163825
Scleroedema 32.36 10.54 10 97241 157 110491891
Pericardial effusion 32.07 10.54 117 97134 57100 110434948
Gait inability 31.84 10.54 44 97207 136332 110355716
Disease progression 31.82 10.54 109 97142 243925 110248123
Injury 31.51 10.54 68 97183 177197 110314851
Cystic fibrosis 31.47 10.54 29 97222 4702 110487346
Psoriasis 31.46 10.54 221 97030 139772 110352276
Adverse drug reaction 31.29 10.54 28 97223 105531 110386517
Live birth 31.26 10.54 11 97240 69473 110422575
Vomiting 31.08 10.54 1033 96218 909642 109582406
Anaemia 30.90 10.54 663 96588 546423 109945625
Osteoarthritis 30.88 10.54 72 97179 182551 110309497
Hypercholesterolaemia 30.84 10.54 21 97230 90816 110401232
Chronic kidney disease 30.84 10.54 141 97110 76150 110415898
Hyperinsulinaemic hypoglycaemia 30.59 10.54 11 97240 281 110491767
Diabetes mellitus 30.54 10.54 170 97081 99211 110392837
Endometrial disorder 30.51 10.54 14 97237 678 110491370
Insulinoma 30.39 10.54 10 97241 194 110491854
Diabetic foot infection 30.18 10.54 15 97236 869 110491179
Sepsis 30.12 10.54 429 96822 326917 110165131
Prescribed overdose 30.07 10.54 20 97231 87561 110404487
Nail disorder 30.06 10.54 7 97244 57928 110434120
Insulin autoimmune syndrome 29.58 10.54 14 97237 728 110491320
Night sweats 29.54 10.54 45 97206 133938 110358110
Onychomadesis 29.38 10.54 3 97248 45660 110446388
Product dispensing error 29.25 10.54 52 97199 16293 110475755
Product use issue 28.58 10.54 159 97092 311536 110180512
Renal impairment 28.56 10.54 272 96979 188173 110303875
Secretion discharge 28.32 10.54 58 97193 20186 110471862
Left atrial dilatation 28.02 10.54 24 97227 3536 110488512
Impaired gastric emptying 27.40 10.54 45 97206 13230 110478818
Atrial fibrillation 27.05 10.54 315 96936 229327 110262721
Drug resistance 26.99 10.54 8 97243 56366 110435682
Epilepsy 26.91 10.54 29 97222 100180 110391868
Clostridium test positive 26.76 10.54 40 97211 10853 110481195
Renal disorder 26.74 10.54 100 97151 49379 110442669
Localised infection 26.68 10.54 91 97160 42957 110449091
Contusion 26.67 10.54 110 97141 233251 110258797
Neck pain 26.53 10.54 42 97209 123088 110368960
Knee arthroplasty 26.40 10.54 12 97239 64936 110427112
Diabetic retinal oedema 26.11 10.54 11 97240 433 110491615
Treatment noncompliance 25.96 10.54 130 97121 72860 110419188
Retinopathy 25.38 10.54 25 97226 4404 110487644
Obesity 25.05 10.54 38 97213 113313 110378735
Transcription medication error 24.98 10.54 12 97239 645 110491403
Rhonchi 24.96 10.54 25 97226 4493 110487555
Vitreous haemorrhage 24.49 10.54 25 97226 4595 110487453
Diaphragmatic disorder 24.22 10.54 17 97234 1869 110490179
Keratitis 24.00 10.54 26 97225 5118 110486930
Infusion site induration 23.97 10.54 15 97236 1361 110490687
Lung disorder 23.75 10.54 80 97171 179967 110312081
Blindness 23.55 10.54 78 97173 36281 110455767
Peripheral swelling 23.23 10.54 235 97016 403799 110088249
Dyspnoea exertional 23.22 10.54 164 97087 103896 110388152
Drug ineffective for unapproved indication 23.19 10.54 34 97217 102804 110389244
Loss of personal independence in daily activities 23.14 10.54 62 97189 149958 110342090
Haematocrit increased 23.02 10.54 25 97226 4934 110487114
Blood ketone body 22.95 10.54 8 97243 186 110491862
Myocardial infarction 22.85 10.54 264 96987 191819 110300229
Medical device site abscess 22.33 10.54 8 97243 202 110491846
Glomerular filtration rate decreased 22.33 10.54 66 97185 28890 110463158
Frequent bowel movements 22.30 10.54 18 97233 71372 110420676
Obstructive airways disorder 22.28 10.54 90 97161 46059 110445989
Therapy non-responder 22.07 10.54 68 97183 157239 110334809
Hypoaldosteronism 21.80 10.54 11 97240 658 110491390
Haemoglobin increased 21.63 10.54 33 97218 9114 110482934
Medical device site cellulitis 21.59 10.54 8 97243 223 110491825
Product name confusion 21.56 10.54 8 97243 224 110491824
Bone erosion 21.45 10.54 7 97244 46364 110445684
Hepatic encephalopathy 21.41 10.54 64 97187 28192 110463856
Hypovolaemia 21.30 10.54 54 97197 21620 110470428
Ischaemic stroke 21.15 10.54 82 97169 41181 110450867
Pruritus 21.11 10.54 372 96879 581188 109910860
Urticaria 21.11 10.54 179 97072 318678 110173370
Febrile neutropenia 20.90 10.54 178 97073 316589 110175459
Hyperhidrosis 20.77 10.54 254 96997 187044 110305004
Cough 20.70 10.54 542 96709 461099 110030949
Pseudomonal bacteraemia 20.23 10.54 22 97229 4349 110487699
Urinary tract infection 20.22 10.54 401 96850 325881 110166167
Malignant neoplasm progression 20.12 10.54 82 97169 174485 110317563
Postprandial hypoglycaemia 20.08 10.54 7 97244 163 110491885
Delirium 19.93 10.54 57 97194 134968 110357080
Pertussis 19.81 10.54 13 97238 1280 110490768
Joint stiffness 19.73 10.54 18 97233 67225 110424823
Dermatitis bullous 19.71 10.54 46 97205 17483 110474565
Diabetic hyperglycaemic coma 19.61 10.54 6 97245 91 110491957
Exostosis 19.46 10.54 8 97243 45948 110446100
Finger deformity 19.29 10.54 3 97248 33089 110458959
Intraventricular haemorrhage 19.26 10.54 24 97227 5483 110486565
Oedematous pancreatitis 19.16 10.54 14 97237 1640 110490408
Blood creatinine increased 18.99 10.54 245 97006 182644 110309404
Neuropathy peripheral 18.97 10.54 241 97010 179036 110313012
Mucosal dryness 18.94 10.54 21 97230 4242 110487806
Foot amputation 18.91 10.54 12 97239 1116 110490932
Muscular weakness 18.77 10.54 315 96936 248153 110243895
Intensive care unit acquired weakness 18.76 10.54 16 97235 2343 110489705
Epileptic encephalopathy 18.70 10.54 10 97241 675 110491373
Mucosal inflammation 18.69 10.54 35 97216 96106 110395942
Glycogen storage disease type VIII 18.37 10.54 4 97247 13 110492035
Patella fracture 18.37 10.54 16 97235 2410 110489638
Nausea 18.33 10.54 1291 95960 1234399 109257649
Musculoskeletal pain 18.08 10.54 91 97160 182932 110309116
Epididymitis 18.05 10.54 16 97235 2468 110489580
Presyncope 18.04 10.54 88 97163 48799 110443249
Pseudolymphoma 17.92 10.54 12 97239 1223 110490825
Cold sweat 17.74 10.54 51 97200 21980 110470068
Acetonaemia 17.57 10.54 9 97242 556 110491492
Neuropathic arthropathy 17.54 10.54 9 97242 558 110491490
Onychomycosis 17.50 10.54 6 97245 38525 110453523
Amylase decreased 17.47 10.54 7 97244 242 110491806
Neutropenic sepsis 17.45 10.54 3 97248 30743 110461305
Diabetic gastroparesis 17.33 10.54 8 97243 393 110491655
Coronary artery disease 17.19 10.54 115 97136 71575 110420473
Croup infectious 17.18 10.54 11 97240 1039 110491009
Neutrophil count decreased 17.16 10.54 52 97199 120889 110371159
Pneumonia 17.06 10.54 938 96313 875776 109616272
Electrolyte imbalance 16.92 10.54 71 97180 36957 110455091
Lower limb fracture 16.90 10.54 25 97226 75323 110416725
Gastrointestinal haemorrhage 16.88 10.54 221 97030 165297 110326751
Sedation 16.75 10.54 22 97229 69661 110422387
Product monitoring error 16.75 10.54 29 97222 8898 110483150
Balanoposthitis 16.74 10.54 12 97239 1364 110490684
Muscle spasms 16.73 10.54 160 97091 277997 110214051
Diabetic wound 16.58 10.54 5 97246 72 110491976
Product prescribing error 16.57 10.54 89 97162 51242 110440806
Immunosuppressant drug level decreased 16.55 10.54 16 97235 2755 110489293
Adverse reaction 16.55 10.54 3 97248 29591 110462457
Depression 16.45 10.54 189 97062 317146 110174902
Acute myocardial infarction 16.40 10.54 128 97123 83649 110408399
Diabetic complication 16.39 10.54 12 97239 1410 110490638
Cognitive disorder 16.02 10.54 33 97218 87478 110404570
Enterococcus test positive 15.92 10.54 16 97235 2888 110489160
Poor quality product administered 15.87 10.54 20 97231 4621 110487427
Pancreatitis acute 15.87 10.54 99 97152 60175 110431873
Hypoxia 15.85 10.54 179 97072 129336 110362712
Polydipsia 15.78 10.54 26 97225 7662 110484386
Psychotic disorder 15.72 10.54 13 97238 50924 110441124
Hypoglycaemic encephalopathy 15.60 10.54 9 97242 704 110491344
Congestive hepatopathy 15.52 10.54 21 97230 5199 110486849
Insulin C-peptide increased 15.47 10.54 6 97245 190 110491858
Microalbuminuria 15.44 10.54 11 97240 1238 110490810
Dawn phenomenon 15.17 10.54 3 97248 5 110492043
Pseudohyponatraemia 15.13 10.54 6 97245 202 110491846
Pulmonary fibrosis 15.11 10.54 43 97208 101999 110390049
Dyspepsia 15.10 10.54 102 97149 190863 110301185
Serotonin syndrome 14.92 10.54 18 97233 59135 110432913
Generalised oedema 14.92 10.54 60 97191 30644 110461404
Head injury 14.86 10.54 76 97175 42941 110449107
Non-cardiogenic pulmonary oedema 14.85 10.54 13 97238 1971 110490077
Blindness transient 14.81 10.54 22 97229 5934 110486114
Chronic obstructive pulmonary disease 14.80 10.54 154 97097 109004 110383044
Full blood count abnormal 14.71 10.54 92 97159 55960 110436088
Infusion site pain 14.69 10.54 41 97210 17378 110474670
Basal cell carcinoma 14.67 10.54 11 97240 45259 110446789
Condition aggravated 14.64 10.54 514 96737 734322 109757726
Intercepted product dispensing error 14.64 10.54 6 97245 220 110491828
Chest pain 14.64 10.54 434 96817 375941 110116107
White blood cell count decreased 14.63 10.54 130 97121 229260 110262788
Cardiac disorder 14.63 10.54 116 97135 76164 110415884
Eye discharge 14.58 10.54 27 97224 8727 110483321
Heart rate decreased 14.49 10.54 32 97219 82724 110409324
Colitis ulcerative 14.31 10.54 29 97222 77334 110414714
Post streptococcal glomerulonephritis 14.28 10.54 5 97246 118 110491930
Varices oesophageal 14.28 10.54 24 97227 7191 110484857
Vascular parkinsonism 14.24 10.54 5 97246 119 110491929
Somogyi phenomenon 14.22 10.54 3 97248 8 110492040
Arteriosclerosis 14.18 10.54 51 97200 24716 110467332
Urinary tract obstruction 14.16 10.54 20 97231 5157 110486891
Leg amputation 14.14 10.54 18 97233 4200 110487848
Laryngitis 14.14 10.54 10 97241 42401 110449647
Hypotension 14.11 10.54 579 96672 523270 109968778
Glycosylated haemoglobin decreased 13.93 10.54 9 97242 863 110491185
Tendonitis 13.84 10.54 3 97248 26080 110465968
Electrocardiogram abnormal 13.82 10.54 42 97209 18667 110473381
Blood ketone body increased 13.78 10.54 9 97242 879 110491169
Neutropenia 13.78 10.54 239 97012 374381 110117667
Dystonia 13.62 10.54 3 97248 25802 110466246
Injury associated with device 13.58 10.54 18 97233 4371 110487677
Lactic acidosis 13.58 10.54 133 97118 92678 110399370
Back injury 13.54 10.54 13 97238 47386 110444662
Medication error 13.52 10.54 147 97104 105219 110386829
Peripheral arterial occlusive disease 13.47 10.54 27 97224 9253 110482795
Adenocarcinoma pancreas 13.39 10.54 13 97238 2250 110489798
Adverse event 13.24 10.54 50 97201 108759 110383289
Weight decreased 13.22 10.54 520 96731 467537 110024511
Blood ketone body present 13.18 10.54 5 97246 149 110491899
Bone marrow failure 13.16 10.54 19 97232 57829 110434219
Myocarditis 13.11 10.54 5 97246 30050 110461998
Osteomyelitis 12.88 10.54 65 97186 36535 110455513
Pancreatic cyst 12.84 10.54 14 97237 2776 110489272
Fasting 12.82 10.54 4 97247 65 110491983
Pyelonephritis 12.80 10.54 50 97201 25200 110466848
Renal transplant 12.77 10.54 15 97236 3223 110488825
Renal tubular disorder 12.48 10.54 23 97228 7406 110484642
Exposure via eye contact 12.44 10.54 3 97248 17 110492031
Bradycardia 12.42 10.54 199 97052 155318 110336730
Urine ketone body present 12.25 10.54 16 97235 3830 110488218
Device expulsion 12.11 10.54 6 97245 30885 110461163
Therapy partial responder 12.01 10.54 9 97242 37052 110454996
Maternal exposure during pregnancy 11.99 10.54 155 97096 254728 110237320
Hypoxic-ischaemic encephalopathy 11.97 10.54 25 97226 8822 110483226
Visual acuity reduced 11.93 10.54 58 97193 32115 110459933
Arrhythmia 11.84 10.54 103 97148 69472 110422576
Skin ulcer 11.77 10.54 96 97155 63549 110428499
Mouth ulceration 11.77 10.54 15 97236 48123 110443925
Intercepted product selection error 11.77 10.54 3 97248 22 110492026
Listeraemia 11.77 10.54 4 97247 86 110491962
Device failure 11.72 10.54 22 97229 7185 110484863
Therapeutic product effect incomplete 11.71 10.54 133 97118 223672 110268376
Gestational hypertension 11.68 10.54 12 97239 2222 110489826
Respiratory depression 11.40 10.54 7 97244 31994 110460054
Neuroleptic malignant syndrome 11.39 10.54 8 97243 34051 110457997
Cytomegalovirus infection 11.32 10.54 19 97232 54425 110437623
Pancreatic carcinoma metastatic 11.26 10.54 16 97235 4148 110487900
Drug reaction with eosinophilia and systemic symptoms 11.15 10.54 36 97215 82059 110409989
Hypercreatinaemia 11.10 10.54 6 97245 414 110491634
Erythema 11.02 10.54 185 97066 291262 110200786
General physical health deterioration 10.98 10.54 468 96783 424827 110067221
Tinnitus 10.94 10.54 23 97228 60517 110431531
Amputation 10.92 10.54 8 97243 941 110491107
Necrotising fasciitis 10.91 10.54 22 97229 7569 110484479
Pulmonary congestion 10.90 10.54 55 97196 30911 110461137
Poisoning 10.89 10.54 6 97245 29099 110462949
Drug dependence 10.83 10.54 17 97234 50003 110442045
Hypertension 10.80 10.54 354 96897 509730 109982318
Prescribed underdose 10.77 10.54 26 97225 65148 110426900
Ear pain 10.68 10.54 19 97232 53207 110438841
Dyspnoea 10.64 10.54 1120 96131 1105752 109386296
Colitis 10.61 10.54 50 97201 102273 110389775
Anaemia of malignant disease 10.57 10.54 8 97243 988 110491060

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10AB04 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
INSULINS AND ANALOGUES
Insulins and analogues for injection, fast-acting
ATC A10AC04 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
INSULINS AND ANALOGUES
Insulins and analogues for injection, intermediate-acting
ATC A10AD04 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
INSULINS AND ANALOGUES
Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
FDA CS M0011417 Insulin
FDA Chemical/Ingredient N0000004931 Insulin
FDA EPC N0000175453 Insulin Analog
FDA EPC N0000175944 Insulin
MeSH PA D007004 Hypoglycemic Agents
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35821 anticholesteremic drug
CHEBI has role CHEBI:39456 antiglaucoma drug
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:50864 insulin-sensitizing drug
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:76916 hyperglycemic agent
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

A10AB Insulins and analogues for injection, fast-acting 5 drugs
insulin aspartinsulin beefinsulin glulisineinsulin humaninsulin pork
A10AC Insulins and analogues for injection, intermediate-acting 3 drugs
insulin beefinsulin humaninsulin pork
A10AD Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting 5 drugs
insulin aspartinsulin beefinsulin degludecinsulin humaninsulin pork

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352
Diabetes mellitus type 1 indication 46635009 DOID:9744




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Insulin receptor Kinase AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
D04477 KEGG_DRUG
4020998 VUID
N0000179468 NUI
4017559 VANDF
4017569 VANDF
4019786 VANDF
4020998 VANDF
4021213 VANDF
CHEBI:232799 CHEBI
CHEMBL1201538 ChEMBL_ID
CHEMBL1201611 ChEMBL_ID
DB00046 DRUGBANK_ID
135805 RXNORM
283144 MMSL
335485 MMSL
4882 MMSL
4885 MMSL
4886 MMSL
6127 MMSL
8603 MMSL
d00262 MMSL
d04369 MMSL
d04373 MMSL
d04511 MMSL
000869 NDDF
000870 NDDF
006061 NDDF
006518 NDDF
007750 NDDF
126210001 SNOMEDCT_US
388454007 SNOMEDCT_US
412210000 SNOMEDCT_US
417423002 SNOMEDCT_US
420609005 SNOMEDCT_US
426313003 SNOMEDCT_US
96367001 SNOMEDCT_US
C0293359 UMLSCUI
D061268 MESH_DESCRIPTOR_UI
C0795635 UMLSCUI
DB00030 DRUGBANK_ID
7278 INN_ID
16132438 PUBCHEM_CID
118984375 PUBCHEM_CID
GFX7QIS1II UNII
5186 INN_ID
CHEBI:5931 CHEBI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Humalog HUMAN PRESCRIPTION DRUG LABEL 1 0002-7510 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 34 sections
Humalog Mix75/25 HUMAN PRESCRIPTION DRUG LABEL 1 0002-7511 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 29 sections
Humalog Mix50/50 HUMAN PRESCRIPTION DRUG LABEL 1 0002-7512 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 29 sections
Humalog HUMAN PRESCRIPTION DRUG LABEL 1 0002-7516 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 34 sections
Humalog HUMAN PRESCRIPTION DRUG LABEL 1 0002-7533 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 34 sections
HumalogKwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-7712 INJECTION, SOLUTION 200 [iU] SUBCUTANEOUS BLA 34 sections
Humalog Junior KwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-7714 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 34 sections
LYUMJEV HUMAN PRESCRIPTION DRUG LABEL 1 0002-7726 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 33 sections
LYUMJEV HUMAN PRESCRIPTION DRUG LABEL 1 0002-7728 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 33 sections
Insulin Lispro HUMAN PRESCRIPTION DRUG LABEL 1 0002-7737 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 33 sections
Insulin Lispro Junior KwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-7752 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 33 sections
LYUMJEV KwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-8207 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 33 sections
HumalogTempo Pen HUMAN PRESCRIPTION DRUG LABEL 1 0002-8208 INJECTION, SOLUTION 200 [iU] SUBCUTANEOUS BLA 34 sections
Humalog Tempo Pen HUMAN PRESCRIPTION DRUG LABEL 1 0002-8213 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 34 sections
Insulin Lispro KwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-8222 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 33 sections
LYUMJEV KwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-8228 INJECTION, SOLUTION 200 [iU] SUBCUTANEOUS BLA 33 sections
Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 KwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-8233 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 29 sections
LYUMJEVTempo Pen HUMAN PRESCRIPTION DRUG LABEL 1 0002-8235 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 33 sections
LYUMJEVJunior KwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-8351 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 33 sections
Humalog Mix75/25 KwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-8797 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 29 sections
Humalog Mix50/50 KwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-8798 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 29 sections
HumalogKwikPen HUMAN PRESCRIPTION DRUG LABEL 1 0002-8799 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 34 sections
ADMELOG HUMAN PRESCRIPTION DRUG LABEL 1 0024-5924 INJECTION, SOLUTION 100 U SUBCUTANEOUS BLA 33 sections
ADMELOG HUMAN PRESCRIPTION DRUG LABEL 1 0024-5925 INJECTION, SOLUTION 100 U SUBCUTANEOUS BLA 33 sections
ADMELOG HUMAN PRESCRIPTION DRUG LABEL 1 0024-5926 INJECTION, SOLUTION 100 U SUBCUTANEOUS BLA 33 sections
HUMALOG HUMAN PRESCRIPTION DRUG LABEL 1 50090-1375 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 32 sections
HumalogKwikPen HUMAN PRESCRIPTION DRUG LABEL 1 50090-1663 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 32 sections
HumalogKwikPen HUMAN PRESCRIPTION DRUG LABEL 1 50090-4073 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 32 sections
HUMALOG HUMAN PRESCRIPTION DRUG LABEL 1 50090-4488 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 32 sections
Insulin Lispro HUMAN PRESCRIPTION DRUG LABEL 1 50090-5391 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 32 sections