All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

insulin lispro 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	5002	133107-64-9

Description:

Molecule	Description
Synonyms: insulin lispro BS lyumjev insulin lispro protamine recombinant insulin lispro protamine insulin lispro humalog insulin lispro recombinant humalog lispro	Insulin that has been modified so that the B-chain contains a LYSINE at position 28 instead of a PROLINE and a PROLINE at position 29 instead of a LYSINE. It is used to manage BLOOD GLUCOSE levels in patients with TYPE 2 DIABETES. Molecular weight: 5807.63 Formula: C257H383N65O77S6 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 2299.07 ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
40	U	P
40	U	P
40	U	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
April 30, 1996	EMA	Eli Lilly Nederland B.V.
June 14, 1996	FDA	LILLY
March 25, 2020	PMDA	Eli Lilly Japan K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Blood glucose increased	2777.74	11.05	1380	53423	82376	63351843
Hypoglycaemia	1402.19	11.05	784	54019	59281	63374938
Blood glucose decreased	653.11	11.05	332	54471	20620	63413599
Diabetic ketoacidosis	639.40	11.05	325	54478	20180	63414039
Diabetes mellitus inadequate control	531.38	11.05	260	54543	14866	63419353
Hyperglycaemia	401.72	11.05	314	54489	41553	63392666
Glycosylated haemoglobin increased	384.93	11.05	196	54607	12202	63422017
Blood glucose abnormal	377.53	11.05	168	54635	7724	63426495
Blood glucose fluctuation	297.15	11.05	121	54682	4455	63429764
Incorrect dose administered	277.70	11.05	299	54504	59669	63374550
Eye haemorrhage	234.11	11.05	124	54679	8372	63425847
Wrong product administered	207.98	11.05	103	54700	6038	63428181
Accidental underdose	164.64	11.05	50	54753	753	63433466
Diabetic retinopathy	156.12	11.05	63	54740	2264	63431955
Hypoglycaemic coma	143.30	11.05	61	54742	2514	63431705
Systemic lupus erythematosus	136.08	11.05	12	54791	208906	63225313
Glossodynia	136.00	11.05	4	54799	178872	63255347
Ketoacidosis	132.34	11.05	68	54735	4310	63429909
Contraindicated product administered	118.94	11.05	22	54781	217626	63216593
Abdominal discomfort	112.48	11.05	69	54734	320816	63113403
Drug intolerance	111.53	11.05	64	54739	308597	63125622
Eye discharge	106.55	11.05	66	54737	5997	63428222
Underdose	104.99	11.05	124	54679	27332	63406887
Treatment failure	104.80	11.05	22	54781	199021	63235198
Gangrene	100.93	11.05	64	54739	6059	63428160
Hypoglycaemic unconsciousness	96.25	11.05	33	54770	744	63433475
Alopecia	96.00	11.05	90	54713	337446	63096773
Blindness	94.80	11.05	105	54698	21594	63412625
Insulin resistance	92.30	11.05	33	54770	845	63433374
Diabetic retinal oedema	91.50	11.05	26	54777	306	63433913
Arterial occlusive disease	90.13	11.05	59	54744	5899	63428320
Product storage error	90.05	11.05	86	54717	14870	63419349
Joint swelling	85.62	11.05	94	54709	327572	63106647
Acute kidney injury	85.02	11.05	450	54353	262965	63171254
Therapeutic product effect decreased	83.77	11.05	31	54772	193156	63241063
Cardiac failure congestive	83.11	11.05	220	54583	92213	63342006
Infusion related reaction	82.97	11.05	55	54748	245466	63188753
Rash	82.80	11.05	231	54572	560640	62873579
Pericarditis	81.86	11.05	9	54794	131570	63302649
Synovitis	81.03	11.05	30	54773	186888	63247331
Cataract	80.26	11.05	162	54641	56891	63377328
Hepatic enzyme increased	75.86	11.05	40	54763	202288	63231931
Discomfort	75.75	11.05	25	54778	167349	63266870
Arthropathy	74.84	11.05	56	54747	234736	63199483
Hypoglycaemia unawareness	74.65	11.05	18	54785	104	63434115
Hypoglycaemic seizure	73.26	11.05	24	54779	468	63433751
Off label use	71.92	11.05	319	54484	674143	62760076
Infective pulmonary exacerbation of cystic fibrosis	71.52	11.05	60	54743	8757	63425462
Product dispensing error	71.22	11.05	64	54739	10241	63423978
Arthralgia	68.50	11.05	257	54546	569453	62864766
Visual acuity reduced	66.52	11.05	88	54715	21738	63412481
Product complaint	64.80	11.05	67	54736	12742	63421477
Intercepted product selection error	63.87	11.05	12	54791	13	63434206
Nasal obstruction	61.49	11.05	30	54773	1701	63432518
Increased insulin requirement	60.09	11.05	14	54789	68	63434151
Helicobacter infection	58.59	11.05	6	54797	92779	63341440
Diabetic neuropathy	56.92	11.05	38	54765	3926	63430293
Visual impairment	56.62	11.05	181	54622	84265	63349954
Swelling	55.76	11.05	95	54708	275283	63158936
Angina pectoris	55.55	11.05	96	54707	29982	63404237
Renal failure	53.31	11.05	222	54581	117430	63316789
Multi-organ disorder	53.10	11.05	26	54777	1486	63432733
Lower respiratory tract infection	52.84	11.05	24	54779	132283	63301936
Throat clearing	52.04	11.05	30	54773	2389	63431830
Product administration error	51.57	11.05	79	54724	22318	63411901
Toxicity to various agents	51.25	11.05	84	54719	247166	63187053
Intercepted product dispensing error	50.82	11.05	13	54790	99	63434120
Loss of consciousness	50.51	11.05	219	54584	117902	63316317
Eye pruritus	50.43	11.05	71	54732	18600	63415619
Injury associated with device	49.90	11.05	34	54769	3632	63430587
Product dose omission issue	49.47	11.05	359	54444	233954	63200265
Musculoskeletal stiffness	49.23	11.05	52	54751	184566	63249653
Anti-insulin antibody increased	48.00	11.05	11	54792	49	63434170
Cerebrovascular accident	46.73	11.05	201	54602	107823	63326396
Folliculitis	45.85	11.05	4	54799	70313	63363906
Product use issue	44.69	11.05	76	54727	220444	63213775
Irritable bowel syndrome	43.57	11.05	9	54794	82403	63351816
Anti-insulin antibody positive	42.09	11.05	11	54792	92	63434127
Pre-eclampsia	39.55	11.05	44	54759	9089	63425130
Hypoglycaemia neonatal	37.98	11.05	18	54785	957	63433262
Diabetes mellitus	36.83	11.05	119	54684	55691	63378528
Diabetic foot	36.72	11.05	20	54783	1427	63432792
Anti-insulin antibody	36.01	11.05	8	54795	30	63434189
Shock hypoglycaemic	35.40	11.05	10	54793	115	63434104
Type 1 diabetes mellitus	35.39	11.05	28	54775	3762	63430457
Drug ineffective	35.07	11.05	664	54139	1044101	62390118
Pain	34.91	11.05	441	54362	740187	62694032
Stomatitis	34.86	11.05	41	54762	138684	63295535
Exposure during pregnancy	34.35	11.05	241	54562	155306	63278913
Transcription medication error	33.74	11.05	11	54792	211	63434008
Blister	33.01	11.05	38	54765	129776	63304443
Completed suicide	32.55	11.05	47	54756	145626	63288593
Large for dates baby	32.14	11.05	13	54790	470	63433749
Neurologic neglect syndrome	31.83	11.05	23	54780	2698	63431521
Carotid artery thrombosis	31.28	11.05	23	54780	2771	63431448
Hyperkalaemia	30.86	11.05	110	54693	54093	63380126
Transient tachypnoea of the newborn	30.51	11.05	9	54794	122	63434097
Rheumatoid arthritis	29.43	11.05	116	54687	253703	63180516
Wound	28.91	11.05	61	54742	163202	63271017
Wrong technique in product usage process	28.50	11.05	118	54685	62222	63371997
Pancreatic carcinoma	28.41	11.05	34	54769	7594	63426625
Mobility decreased	28.15	11.05	38	54765	121121	63313098
Ill-defined disorder	28.00	11.05	18	54785	81737	63352482
Ventricular septal defect	27.93	11.05	26	54777	4352	63429867
Keratitis	27.16	11.05	23	54780	3399	63430820
Diabetic complication	27.07	11.05	14	54789	899	63433320
Epileptic encephalopathy	26.90	11.05	10	54793	287	63433932
Intentional product use issue	26.89	11.05	43	54760	127849	63306370
Pseudomonal bacteraemia	26.79	11.05	17	54786	1611	63432608
Chronic kidney disease	26.59	11.05	93	54710	45305	63388914
Thyroid disorder	26.19	11.05	47	54756	15115	63419104
Rhonchi	26.16	11.05	20	54783	2556	63431663
Diabetic nephropathy	25.98	11.05	16	54787	1438	63432781
Acute respiratory failure	25.97	11.05	77	54726	34408	63399811
Hip arthroplasty	25.60	11.05	5	54798	47641	63386578
Sopor	25.47	11.05	58	54745	22106	63412113
Small for dates baby	25.34	11.05	23	54780	3728	63430491
Treatment noncompliance	25.00	11.05	80	54723	37245	63396974
Neuropathic arthropathy	24.38	11.05	9	54794	253	63433966
Malignant neoplasm progression	24.36	11.05	21	54782	82100	63352119
Urinary tract obstruction	24.33	11.05	18	54785	2190	63432029
Dopamine transporter scintigraphy abnormal	24.21	11.05	7	54796	88	63434131
Croup infectious	24.11	11.05	11	54792	536	63433683
Cystic fibrosis	23.83	11.05	21	54782	3275	63430944
Expired product administered	23.76	11.05	28	54775	6153	63428066
Device operational issue	23.61	11.05	9	54794	277	63433942
Personality disorder	23.47	11.05	27	54776	5784	63428435
Premature delivery	23.17	11.05	68	54735	30213	63404006
Blood ketone body	22.98	11.05	6	54797	50	63434169
Anaemia	22.88	11.05	368	54435	293062	63141157
Intensive care unit acquired weakness	22.66	11.05	12	54791	809	63433410
Secretion discharge	22.53	11.05	39	54764	12192	63422027
Disease progression	22.46	11.05	45	54758	122713	63311506
Generalised oedema	22.33	11.05	45	54758	15773	63418446
Dyspnoea exertional	22.18	11.05	107	54696	60195	63374024
Myocardial infarction	22.17	11.05	155	54648	99738	63334481
Psoriatic arthropathy	21.98	11.05	28	54775	91492	63342727
Ischaemic stroke	21.77	11.05	48	54755	17909	63416310
Insulin C-peptide decreased	21.69	11.05	5	54798	23	63434196
Eye irritation	21.48	11.05	54	54749	21917	63412302
Coronary artery disease	21.32	11.05	69	54734	32308	63401911
Endometrial disorder	20.96	11.05	11	54792	728	63433491
Retinopathy	20.82	11.05	19	54784	3100	63431119
Fall	20.28	11.05	462	54341	391872	63042347
Patella fracture	20.22	11.05	16	54787	2150	63432069
Loss of personal independence in daily activities	20.18	11.05	33	54770	97257	63336962
Wrong patient received product	19.96	11.05	16	54787	2191	63432028
Knee arthroplasty	19.88	11.05	11	54792	54195	63380024
Drug hypersensitivity	19.87	11.05	172	54631	310515	63123704
Blood ketone body increased	19.70	11.05	8	54795	292	63433927
Hospitalisation	19.46	11.05	133	54670	84948	63349271
General physical health deterioration	19.38	11.05	262	54541	201140	63233079
Diabetic hyperglycaemic coma	19.33	11.05	5	54798	40	63434179
Electrolyte imbalance	19.27	11.05	49	54754	20027	63414192
Hypersensitivity	19.18	11.05	161	54642	292524	63141695
Foetal exposure during pregnancy	19.17	11.05	66	54737	31896	63402323
Red blood cell sedimentation rate increased	19.14	11.05	7	54796	43975	63390244
Vitreous haemorrhage	18.83	11.05	15	54788	2035	63432184
Pertussis	18.79	11.05	10	54793	681	63433538
Intercepted product prescribing error	18.76	11.05	7	54796	203	63434016
Enterococcus test positive	18.68	11.05	12	54791	1161	63433058
Malnutrition	18.66	11.05	41	54762	15257	63418962
Peritonitis bacterial	18.59	11.05	22	54781	4857	63429362
Liver injury	18.54	11.05	15	54788	60505	63373714
Adverse drug reaction	18.52	11.05	25	54778	79689	63354530
Diabetic coma	18.44	11.05	10	54793	707	63433512
Oedema peripheral	18.43	11.05	247	54556	189264	63244955
Urine ketone body present	18.20	11.05	16	54787	2487	63431732
Product use in unapproved indication	18.20	11.05	86	54717	178994	63255225
Gastrointestinal disorder	17.86	11.05	56	54747	131183	63303036
Insomnia	17.67	11.05	111	54692	215141	63219078
Urinary tract infection	17.39	11.05	323	54480	264361	63169858
Gastric disorder	17.29	11.05	71	54732	37298	63396921
Medication error	17.27	11.05	90	54713	52194	63382025
Renal impairment	17.26	11.05	133	54670	88222	63345997
Fasting	17.24	11.05	4	54799	19	63434200
Pulmonary oedema	17.13	11.05	93	54710	54780	63379439
Inflammatory marker increased	16.99	11.05	25	54778	6814	63427405
Neuropathy peripheral	16.89	11.05	161	54642	113506	63320713
Dermatitis bullous	16.82	11.05	28	54775	8480	63425739
Blood cholesterol increased	16.75	11.05	35	54768	93997	63340222
Gestational hypertension	16.68	11.05	15	54788	2402	63431817
Hyperinsulinaemic hypoglycaemia	16.61	11.05	5	54798	73	63434146
Impaired gastric emptying	16.55	11.05	31	54772	10301	63423918
Chest pain	16.50	11.05	270	54533	215689	63218530
Euglycaemic diabetic ketoacidosis	16.43	11.05	18	54785	3656	63430563
Peripheral swelling	16.22	11.05	149	54654	265793	63168426
Thyroid cancer	16.14	11.05	22	54781	5589	63428630
C-reactive protein abnormal	15.99	11.05	10	54793	46086	63388133
Motor dysfunction	15.65	11.05	31	54772	10730	63423489
Dawn phenomenon	15.63	11.05	3	54800	4	63434215
Dry mouth	15.60	11.05	27	54776	77836	63356383
Foetal hypokinesia	15.49	11.05	8	54795	512	63433707
Sepsis	15.47	11.05	201	54602	152922	63281297
Hemiplegia	14.96	11.05	28	54775	9295	63424924
Caesarean section	14.74	11.05	40	54763	16992	63417227
Anuria	14.60	11.05	33	54770	12518	63421701
End stage renal disease	14.56	11.05	23	54780	6670	63427549
Nasopharyngitis	14.42	11.05	145	54658	254112	63180107
Ketosis	14.26	11.05	8	54795	605	63433614
Congestive hepatopathy	14.18	11.05	15	54788	2927	63431292
Vascular parkinsonism	14.02	11.05	5	54798	127	63434092
Infusion site pain	13.99	11.05	39	54764	16830	63417389
Renal disorder	13.97	11.05	61	54742	32913	63401306
Pancreatic disorder	13.93	11.05	14	54789	2574	63431645
Peripheral sensorimotor neuropathy	13.81	11.05	11	54792	1492	63432727
Cutaneous amyloidosis	13.78	11.05	3	54800	10	63434209
Chronic obstructive pulmonary disease	13.75	11.05	97	54706	62589	63371630
Incorrect product dosage form administered	13.50	11.05	5	54798	142	63434077
Premature baby	13.48	11.05	44	54759	20691	63413528
Tachypnoea	13.38	11.05	39	54764	17263	63416956
Blood pressure increased	13.27	11.05	205	54598	161857	63272362
Adjustment disorder	13.23	11.05	15	54788	3163	63431056
Sensory loss	13.13	11.05	28	54775	10210	63424009
Fatigue	13.13	11.05	630	54173	887398	62546821
Product prescribing error	13.00	11.05	51	54752	26238	63407981
Blindness unilateral	12.96	11.05	21	54782	6220	63427999
Device expulsion	12.93	11.05	7	54796	34915	63399304
Bursitis	12.90	11.05	8	54795	37033	63397186
Hypoacusis	12.89	11.05	48	54755	24103	63410116
Postprandial hypoglycaemia	12.72	11.05	4	54799	68	63434151
Flank pain	12.70	11.05	37	54766	16373	63417846
Cellulitis	12.63	11.05	117	54686	81841	63352378
Febrile neutropenia	12.55	11.05	56	54747	118393	63315826
Hypervolaemia	12.37	11.05	53	54750	28360	63405859
Listeraemia	12.36	11.05	4	54799	75	63434144
Adenocarcinoma pancreas	12.35	11.05	9	54794	1069	63433150
White blood cell count decreased	12.32	11.05	70	54733	139034	63295185
Arteriosclerosis	12.30	11.05	27	54776	10039	63424180
Sinus congestion	12.28	11.05	39	54764	18084	63416135
Skin haemorrhage	12.25	11.05	27	54776	10067	63424152
Product name confusion	12.21	11.05	4	54799	78	63434141
Localised infection	12.13	11.05	55	54748	30155	63404064
Drug abuse	12.08	11.05	28	54775	72490	63361729
Cardiac death	11.87	11.05	7	54796	582	63433637
Polydipsia	11.84	11.05	15	54788	3549	63430670
Pyelonephritis	11.81	11.05	38	54765	17740	63416479
Pallor	11.79	11.05	55	54748	30513	63403706
Infection	11.66	11.05	134	54669	229039	63205180
Hypertriglyceridaemia	11.58	11.05	20	54783	6239	63427980
Dehydration	11.53	11.05	212	54591	173142	63261077
Hepatic cirrhosis	11.44	11.05	47	54756	24687	63409532
Toe amputation	11.25	11.05	11	54792	1956	63432263
Coronary artery occlusion	11.20	11.05	23	54780	8168	63426051
Gastroschisis	11.16	11.05	6	54797	417	63433802
Blood potassium increased	11.15	11.05	38	54765	18271	63415948

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Blood glucose increased	1879.50	11.16	1118	42588	65600	34847625
Hypoglycaemia	1193.58	11.16	780	42926	53860	34859365
Blood glucose decreased	421.63	11.16	241	43465	12996	34900229
Diabetic ketoacidosis	386.73	11.16	255	43451	17777	34895448
Hyperglycaemia	374.23	11.16	344	43362	39136	34874089
Diabetes mellitus inadequate control	339.77	11.16	211	43495	13253	34899972
Glycosylated haemoglobin increased	299.28	11.16	183	43523	11177	34902048
Blood glucose abnormal	290.29	11.16	144	43562	5808	34907417
Incorrect dose administered	236.38	11.16	272	43434	40243	34872982
Wrong product administered	156.19	11.16	92	43614	5242	34907983
Hypoglycaemic coma	155.81	11.16	71	43635	2360	34910865
Hypoglycaemic unconsciousness	146.74	11.16	50	43656	748	34912477
Anti-insulin antibody positive	128.72	11.16	33	43673	165	34913060
Toxicity to various agents	122.02	11.16	49	43657	200313	34712912
Blood glucose fluctuation	121.69	11.16	71	43635	3973	34909252
Diabetic retinopathy	94.67	11.16	46	43660	1771	34911454
Accidental underdose	89.81	11.16	31	43675	483	34912742
Underdose	87.93	11.16	97	43609	13683	34899542
Intercepted product selection error	83.22	11.16	16	43690	10	34913215
Ketoacidosis	76.63	11.16	54	43652	4189	34909036
Product storage error	71.50	11.16	68	43638	8054	34905171
Hypoglycaemic seizure	69.56	11.16	23	43683	312	34912913
Drug abuse	62.28	11.16	23	43683	99073	34814152
Off label use	56.37	11.16	302	43404	419222	34494003
Product dispensing error	56.13	11.16	53	43653	6221	34907004
Hypoglycaemia unawareness	55.65	11.16	16	43690	131	34913094
Completed suicide	54.96	11.16	27	43679	98141	34815084
Acute kidney injury	54.77	11.16	602	43104	304386	34608839
Infusion site pain	51.65	11.16	41	43665	3810	34909415
Diabetic metabolic decompensation	47.90	11.16	29	43677	1737	34911488
Infective pulmonary exacerbation of cystic fibrosis	47.10	11.16	50	43656	6751	34906474
Diabetic neuropathy	46.51	11.16	40	43666	4157	34909068
Product complaint	45.65	11.16	46	43660	5844	34907381
Insulin resistance	44.65	11.16	20	43686	638	34912587
Foetal disorder	43.30	11.16	21	43685	805	34912420
Intercepted product dispensing error	40.67	11.16	11	43695	70	34913155
Anti-insulin antibody	39.78	11.16	9	43697	23	34913202
Blindness	38.42	11.16	68	43638	14918	34898307
Anti-insulin antibody increased	36.15	11.16	10	43696	70	34913155
Impaired gastric emptying	34.44	11.16	31	43675	3422	34909803
Neutropenia neonatal	34.04	11.16	17	43689	695	34912530
Visual impairment	32.82	11.16	109	43597	35693	34877532
Wrong technique in product usage process	32.49	11.16	109	43597	35877	34877348
Cutaneous amyloidosis	32.26	11.16	8	43698	34	34913191
Medication error	32.11	11.16	87	43619	25478	34887747
Retinopathy	32.11	11.16	24	43682	2040	34911185
Febrile neutropenia	31.15	11.16	79	43627	136770	34776455
Sopor	31.02	11.16	55	43651	12081	34901144
Hypoaldosteronism	30.98	11.16	11	43695	187	34913038
Pancreatic carcinoma	30.42	11.16	46	43660	8855	34904370
Product dose omission issue	30.13	11.16	254	43452	119457	34793768
Hyperkalaemia	29.20	11.16	167	43539	69222	34844003
Diabetic gastroparesis	27.71	11.16	9	43697	115	34913110
Skin ulcer	27.30	11.16	75	43631	22141	34891084
Diaphragmatic disorder	27.23	11.16	18	43688	1257	34911968
Type 1 diabetes mellitus	27.20	11.16	30	43676	4228	34908997
Oedematous pancreatitis	27.15	11.16	13	43693	484	34912741
Dehydration	26.73	11.16	264	43442	129705	34783520
Left atrial dilatation	26.23	11.16	21	43685	1975	34911250
Diabetic foot infection	26.09	11.16	14	43692	665	34912560
Toe amputation	25.85	11.16	23	43683	2501	34910724
Visual acuity reduced	25.56	11.16	60	43646	16089	34897136
Systemic infection	25.45	11.16	32	43674	5180	34908045
Hospitalisation	25.30	11.16	139	43567	56763	34856462
Shock hypoglycaemic	25.24	11.16	8	43698	94	34913131
Infusion site induration	25.20	11.16	10	43696	234	34912991
Diabetic nephropathy	25.05	11.16	21	43685	2107	34911118
Diabetic coma	24.72	11.16	15	43691	902	34912323
Loss of personal independence in daily activities	23.90	11.16	6	43700	33173	34880052
Haemoglobin increased	23.49	11.16	25	43681	3384	34909841
Product monitoring error	23.17	11.16	28	43678	4353	34908872
Haematocrit increased	23.13	11.16	20	43686	2093	34911132
Leg amputation	22.40	11.16	20	43686	2184	34911041
Diabetic foot	22.02	11.16	22	43684	2766	34910459
Mucosal dryness	21.88	11.16	16	43690	1315	34911910
Treatment failure	21.69	11.16	16	43690	46681	34866544
Ketosis	21.21	11.16	11	43695	487	34912738
Cardiac failure congestive	21.11	11.16	177	43529	83093	34830132
Renal disorder	21.10	11.16	75	43631	25405	34887820
Premature baby	20.95	11.16	63	43643	19570	34893655
VACTERL syndrome	20.78	11.16	6	43700	50	34913175
Pseudolymphoma	20.75	11.16	12	43694	660	34912565
Acute respiratory failure	20.64	11.16	85	43621	30843	34882382
Weight increased	20.61	11.16	192	43514	92841	34820384
Increased insulin requirement	20.59	11.16	7	43699	104	34913121
Loss of consciousness	20.57	11.16	175	43531	82492	34830733
Oedema peripheral	19.81	11.16	233	43473	119579	34793646
Cerebrovascular accident	19.78	11.16	177	43529	84634	34828591
Multiple organ dysfunction syndrome	19.16	11.16	42	43664	76524	34836701
Pseudohyponatraemia	19.13	11.16	6	43700	68	34913157
Neutropenia	18.71	11.16	117	43589	156661	34756564
Product use in unapproved indication	18.34	11.16	80	43626	117419	34795806
Mucosal inflammation	18.24	11.16	13	43693	38609	34874616
Blood ketone body	18.17	11.16	6	43700	81	34913144
Device operational issue	17.56	11.16	7	43699	166	34913059
Diabetes mellitus	17.27	11.16	109	43597	46764	34866461
Malignant neoplasm progression	16.95	11.16	55	43651	87991	34825234
Balanoposthitis	16.57	11.16	13	43693	1187	34912038
Localised infection	16.52	11.16	54	43652	17533	34895692
Rash	16.32	11.16	189	43517	222563	34690662
Drug resistance	16.30	11.16	6	43700	25921	34887304
Treatment noncompliance	16.28	11.16	74	43632	28026	34885199
Fall	16.12	11.16	349	43357	202536	34710689
Somnolence	15.95	11.16	78	43628	111038	34802187
Chronic kidney disease	15.92	11.16	97	43609	41113	34872112
Injection site pain	15.83	11.16	93	43613	38912	34874313
Incorrect product formulation administered	15.77	11.16	4	43702	19	34913206
Cold sweat	15.69	11.16	37	43669	9950	34903275
Intentional product use issue	15.64	11.16	32	43674	59784	34853441
Serotonin syndrome	15.58	11.16	3	43703	19930	34893295
Expired product administered	15.50	11.16	20	43686	3321	34909904
Disease progression	15.43	11.16	76	43630	108001	34805224
Cellulitis	15.29	11.16	116	43590	52835	34860390
Product name confusion	15.18	11.16	5	43701	67	34913158
Injury associated with device	15.15	11.16	12	43694	1111	34912114
Arthralgia	15.03	11.16	138	43568	169903	34743322
Road traffic accident	14.99	11.16	52	43654	17398	34895827
Poor quality product administered	14.97	11.16	15	43691	1892	34911333
Agitation	14.76	11.16	31	43675	57368	34855857
Osteomyelitis	14.67	11.16	49	43657	16087	34897138
Hemivertebra	14.64	11.16	6	43700	153	34913072
Intraventricular haemorrhage	14.63	11.16	20	43686	3511	34909714
Hypervolaemia	14.62	11.16	56	43650	19653	34893572
Drug dependence	14.57	11.16	6	43700	24211	34889014
Meningitis aseptic	14.49	11.16	19	43687	3205	34910020
Foot amputation	14.48	11.16	10	43696	751	34912474
Lipohypertrophy	14.37	11.16	7	43699	271	34912954
Rheumatoid arthritis	14.31	11.16	16	43690	38222	34875003
Drug ineffective for unapproved indication	14.07	11.16	6	43700	23709	34889516
Enterobacter pneumonia	13.92	11.16	5	43701	88	34913137
Hypoglycaemic encephalopathy	13.88	11.16	7	43699	292	34912933
Bone marrow failure	13.62	11.16	10	43696	29243	34883982
Diabetic hyperglycaemic coma	13.58	11.16	4	43702	36	34913189
Peritonitis bacterial	13.49	11.16	26	43680	6084	34907141
Epididymitis	13.47	11.16	16	43690	2443	34910782
Pulmonary embolism	13.46	11.16	62	43644	89684	34823541
Joint swelling	13.28	11.16	35	43671	59855	34853370
Presyncope	13.21	11.16	53	43653	19006	34894219
Oedematous kidney	13.20	11.16	4	43702	40	34913185
Cystic fibrosis	12.94	11.16	13	43693	1645	34911580
Atrial fibrillation	12.94	11.16	220	43486	122173	34791052
Weight loss poor	12.93	11.16	6	43700	208	34913017
Myelosuppression	12.91	11.16	4	43702	19261	34893964
Hepatic encephalopathy	12.82	11.16	44	43662	14641	34898584
Injection site nodule	12.78	11.16	13	43693	1670	34911555
Primary biliary cholangitis	12.64	11.16	6	43700	219	34913006
Insulin C-peptide decreased	12.62	11.16	4	43702	47	34913178
Post streptococcal glomerulonephritis	12.41	11.16	5	43701	122	34913103
Blood ketone body present	12.25	11.16	4	43702	52	34913173
Glycogen storage disease type VIII	12.24	11.16	3	43703	12	34913213
Impaired insulin secretion	12.24	11.16	3	43703	12	34913213
Blindness unilateral	12.15	11.16	21	43685	4521	34908704
Impaired fasting glucose	12.13	11.16	6	43700	240	34912985
Diabetic gangrene	11.95	11.16	6	43700	248	34912977
Postprandial hypoglycaemia	11.87	11.16	3	43703	14	34913211
Toxic epidermal necrolysis	11.79	11.16	56	43650	21590	34891635
Cataract	11.65	11.16	64	43642	26122	34887103
Eye haemorrhage	11.64	11.16	20	43686	4285	34908940
Lichenoid keratosis	11.62	11.16	15	43691	2493	34910732
Respiratory depression	11.58	11.16	3	43703	16242	34896983
Neuroleptic malignant syndrome	11.53	11.16	4	43702	17930	34895295
Sedation	11.41	11.16	6	43700	21000	34892225
Retrognathia	11.30	11.16	6	43700	279	34912946
Blood pressure fluctuation	11.28	11.16	9	43697	25240	34887985
Pancreatic carcinoma metastatic	11.21	11.16	16	43690	2924	34910301

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoglycaemia	2211.74	10.04	1314	75166	100280	79567628
Blood glucose increased	1977.45	10.04	1280	75200	113695	79554213
Diabetic ketoacidosis	729.41	10.04	437	76043	33685	79634223
Diabetes mellitus inadequate control	661.02	10.04	364	76116	23900	79644008
Hyperglycaemia	614.92	10.04	522	75958	69813	79598095
Blood glucose decreased	589.39	10.04	347	76133	25887	79642021
Glycosylated haemoglobin increased	433.22	10.04	255	76225	19005	79648903
Blood glucose fluctuation	246.91	10.04	123	76357	6559	79661349
Blood glucose abnormal	243.13	10.04	142	76338	10424	79657484
Hypoglycaemic coma	241.48	10.04	109	76371	4651	79663257
Acute kidney injury	166.72	10.04	956	75524	518448	79149460
Ketoacidosis	166.18	10.04	100	76380	7754	79660154
Anti-insulin antibody positive	153.28	10.04	39	76441	257	79667651
Toxicity to various agents	150.37	10.04	111	76369	421429	79246479
Hypoglycaemic unconsciousness	132.91	10.04	48	76432	1135	79666773
Wrong product administered	120.28	10.04	86	76394	8926	79658982
Hypoglycaemic seizure	113.86	10.04	39	76441	785	79667123
Infective pulmonary exacerbation of cystic fibrosis	97.35	10.04	88	76392	12763	79655145
Off label use	94.56	10.04	499	75981	906716	78761192
Product complaint	94.48	10.04	88	76392	13261	79654647
Drug intolerance	93.50	10.04	70	76410	264049	79403859
Gangrene	91.77	10.04	73	76407	8891	79659017
Diabetic retinopathy	91.21	10.04	49	76431	3057	79664851
Systemic lupus erythematosus	89.60	10.04	7	76473	121142	79546766
Cardiac failure congestive	86.71	10.04	317	76163	142085	79525823
Insulin resistance	84.27	10.04	36	76444	1343	79666565
Completed suicide	82.12	10.04	69	76411	245698	79422210
Incorrect dose administered	82.00	10.04	208	76272	76422	79591486
Eye haemorrhage	80.24	10.04	70	76410	9687	79658221
Glossodynia	79.23	10.04	5	76475	103332	79564576
Treatment failure	77.81	10.04	33	76447	170453	79497455
Anti-insulin antibody increased	77.68	10.04	19	76461	104	79667804
Hypoglycaemia unawareness	74.19	10.04	21	76459	217	79667691
Rash	68.89	10.04	303	76177	578055	79089853
Drug ineffective	68.24	10.04	686	75794	1080227	78587681
Therapeutic product effect decreased	68.20	10.04	36	76444	163827	79504081
Joint swelling	67.36	10.04	108	76372	288538	79379370
Arterial occlusive disease	66.21	10.04	59	76421	8397	79659511
Hyperkalaemia	64.91	10.04	249	76231	114149	79553759
Loss of consciousness	63.69	10.04	324	76156	167619	79500289
Alopecia	63.53	10.04	77	76403	231278	79436630
Synovitis	62.90	10.04	33	76447	150701	79517207
Pericarditis	62.58	10.04	12	76468	104224	79563684
Arthralgia	61.94	10.04	310	76170	571493	79096415
Infusion related reaction	61.78	10.04	78	76402	230159	79437749
Increased insulin requirement	60.56	10.04	17	76463	170	79667738
Anti-insulin antibody	59.50	10.04	14	76466	63	79667845
Abdominal discomfort	59.26	10.04	93	76387	250634	79417274
Arthropathy	55.22	10.04	53	76427	177058	79490850
Nasal obstruction	54.90	10.04	31	76449	2133	79665775
Accidental underdose	54.32	10.04	23	76457	839	79667069
Acute respiratory failure	53.97	10.04	152	76328	59389	79608519
Drug abuse	52.71	10.04	47	76433	162644	79505264
Sopor	52.58	10.04	105	76375	32905	79635003
Product administration error	50.37	10.04	101	76379	31745	79636163
Diabetic neuropathy	49.92	10.04	44	76436	6172	79661736
Cutaneous amyloidosis	48.62	10.04	11	76469	40	79667868
Pancreatic carcinoma	47.79	10.04	62	76418	13515	79654393
Throat clearing	46.56	10.04	30	76450	2624	79665284
Helicobacter infection	46.41	10.04	6	76474	69698	79598210
Lower respiratory tract infection	46.01	10.04	34	76446	129186	79538722
Angina pectoris	45.85	10.04	131	76349	51601	79616307
General physical health deterioration	45.45	10.04	433	76047	274805	79393103
Oedema peripheral	45.24	10.04	404	76076	251884	79416024
Shock hypoglycaemic	42.80	10.04	14	76466	243	79667665
Multi-organ disorder	42.33	10.04	28	76452	2560	79665348
Type 1 diabetes mellitus	42.14	10.04	42	76438	6877	79661031
Dehydration	41.24	10.04	391	76089	247796	79420112
Diabetic metabolic decompensation	40.38	10.04	30	76450	3302	79664606
Musculoskeletal stiffness	40.31	10.04	66	76414	174942	79492966
Diabetic foot	40.25	10.04	31	76449	3601	79664307
Product storage error	37.91	10.04	61	76419	16165	79651743
Cerebrovascular accident	37.30	10.04	266	76214	155026	79512882
Device operational issue	37.02	10.04	14	76466	378	79667530
Hepatic enzyme increased	35.75	10.04	76	76404	182534	79485374
Intentional product use issue	35.37	10.04	57	76423	152055	79515853
Muscle injury	35.36	10.04	3	76477	48558	79619350
Cataract	35.05	10.04	135	76345	61985	79605923
Diabetes mellitus	34.57	10.04	158	76322	78232	79589676
Diabetic nephropathy	34.53	10.04	26	76454	2921	79664987
Cystic fibrosis	34.27	10.04	29	76451	3851	79664057
Stomatitis	34.12	10.04	55	76425	146702	79521206
Contraindicated product administered	33.92	10.04	62	76418	157476	79510432
Anaemia	33.81	10.04	607	75873	444408	79223500
Irritable bowel syndrome	33.68	10.04	9	76471	62232	79605676
Treatment noncompliance	33.18	10.04	118	76362	52150	79615758
Pre-eclampsia	32.69	10.04	37	76443	7004	79660904
Systemic infection	31.96	10.04	43	76437	9709	79658199
Folliculitis	31.94	10.04	7	76473	55373	79612535
Medication error	31.50	10.04	140	76340	68502	79599406
Peritonitis bacterial	31.07	10.04	42	76438	9525	79658383
Loss of personal independence in daily activities	30.47	10.04	32	76448	102548	79565360
Swelling	29.87	10.04	107	76373	216604	79451304
Transcription medication error	28.36	10.04	12	76468	437	79667471
Red blood cell sedimentation rate increased	28.19	10.04	5	76475	45937	79621971
Toe amputation	28.09	10.04	26	76454	3885	79664023
Keratitis	27.74	10.04	27	76453	4295	79663613
Hyperinsulinaemic hypoglycaemia	27.47	10.04	9	76471	157	79667751
Carotid artery thrombosis	27.34	10.04	23	76457	3030	79664878
Diabetic foot infection	27.31	10.04	14	76466	793	79667115
Impaired gastric emptying	27.08	10.04	41	76439	10312	79657596
Renal failure	26.89	10.04	303	76177	200665	79467243
Hypoaldosteronism	26.68	10.04	11	76469	375	79667533
Ill-defined disorder	26.63	10.04	15	76465	65860	79602048
Asthenia	26.50	10.04	660	75820	511029	79156879
Diaphragmatic disorder	26.39	10.04	18	76462	1732	79666176
Neurologic neglect syndrome	26.24	10.04	22	76458	2885	79665023
Febrile neutropenia	26.23	10.04	123	76357	230876	79437032
Hypervolaemia	25.92	10.04	95	76385	42595	79625313
Ketosis	25.55	10.04	15	76465	1111	79666797
Rhonchi	25.51	10.04	25	76455	4011	79663897
Infusion site induration	25.44	10.04	15	76465	1120	79666788
Rheumatoid arthritis	24.87	10.04	109	76371	208361	79459547
Blood ketone body	24.61	10.04	8	76472	136	79667772
Postprandial hypoglycaemia	24.09	10.04	7	76473	80	79667828
Diabetic coma	24.09	10.04	15	76465	1236	79666672
Diabetic retinal oedema	24.03	10.04	10	76470	349	79667559
Hip arthroplasty	23.99	10.04	3	76477	35753	79632155
Blister	23.99	10.04	49	76431	119427	79548481
Syncope	23.76	10.04	270	76210	179179	79488729
Hypersensitivity	23.53	10.04	151	76329	262088	79405820
Chronic kidney disease	23.24	10.04	125	76355	66029	79601879
Renal impairment	23	10.04	242	76238	157541	79510367
Cellulitis	22.89	10.04	181	76299	108879	79559029
Product name confusion	22.82	10.04	8	76472	173	79667735
Sepsis	22.77	10.04	374	76106	269054	79398854
Left atrial dilatation	22.72	10.04	21	76459	3132	79664776
Fall	22.64	10.04	620	75860	487009	79180899
Product dose omission issue	22.57	10.04	348	76132	247189	79420719
Retinopathy	22.56	10.04	23	76457	3868	79664040
Renal disorder	22.53	10.04	90	76390	42015	79625893
Atrial fibrillation	22.38	10.04	289	76191	197597	79470311
Weight increased	22.33	10.04	382	76098	277004	79390904
Endometrial disorder	21.74	10.04	11	76469	606	79667302
Myelosuppression	21.48	10.04	6	76474	40290	79627618
Gastrointestinal disorder	21.38	10.04	54	76426	122151	79545757
Mobility decreased	21.37	10.04	54	76426	122121	79545787
Hypovolaemia	21.01	10.04	50	76430	17641	79650267
Epileptic encephalopathy	20.93	10.04	10	76470	486	79667422
Product dispensing error	20.89	10.04	42	76438	13221	79654687
Malignant neoplasm progression	20.89	10.04	64	76416	135926	79531982
Disease progression	20.44	10.04	99	76381	184263	79483645
Epididymitis	20.36	10.04	16	76464	1914	79665994
Product use issue	20.29	10.04	118	76362	209704	79458204
Haematocrit increased	20.11	10.04	22	76458	4012	79663896
Product use in unapproved indication	20.07	10.04	149	76331	250210	79417698
Oedematous pancreatitis	19.99	10.04	13	76467	1155	79666753
Personality disorder	19.99	10.04	27	76453	6119	79661789
Vitreous haemorrhage	19.83	10.04	21	76459	3692	79664216
Foot amputation	19.64	10.04	12	76468	956	79666952
Drug resistance	19.52	10.04	8	76472	42205	79625703
Adverse drug reaction	19.39	10.04	21	76459	66371	79601537
Diabetic hyperglycaemic coma	19.34	10.04	6	76474	87	79667821
Hepatic encephalopathy	19.31	10.04	59	76421	24107	79643801
Presyncope	19.04	10.04	84	76396	40970	79626938
Electrolyte imbalance	18.99	10.04	69	76411	30812	79637096
Eye discharge	18.85	10.04	26	76454	6008	79661900
Discomfort	18.67	10.04	60	76420	125557	79542351
Haemoglobin increased	18.53	10.04	26	76454	6106	79661802
Hyperhidrosis	18.30	10.04	224	76256	151268	79516640
Patella fracture	18.30	10.04	15	76465	1906	79666002
Localised infection	18.28	10.04	78	76402	37497	79630411
Pertussis	18.15	10.04	11	76469	864	79667044
Thyroid disorder	18.05	10.04	41	76439	14038	79653870
Glycogen storage disease type VIII	18.03	10.04	4	76476	13	79667895
Glomerular filtration rate decreased	17.75	10.04	55	76425	22647	79645261
Blood insulin increased	17.49	10.04	8	76472	352	79667556
Dyspnoea exertional	17.45	10.04	143	76337	86930	79580978
Diabetic gastroparesis	17.45	10.04	8	76472	354	79667554
Neutropenia	17.43	10.04	184	76296	287526	79380382
Neuropathic arthropathy	17.38	10.04	8	76472	357	79667551
Pseudolymphoma	17.24	10.04	12	76468	1193	79666715
Balanoposthitis	17.10	10.04	11	76469	959	79666949
Blindness	17.10	10.04	63	76417	28320	79639588
Dyspnoea	17.07	10.04	994	75486	856031	78811877
Pseudohyponatraemia	17.06	10.04	6	76474	131	79667777
Croup infectious	16.97	10.04	10	76470	746	79667162
C-reactive protein abnormal	16.86	10.04	13	76467	48354	79619554
Dermatitis bullous	16.64	10.04	40	76440	14205	79653703
Neutropenic sepsis	16.49	10.04	3	76477	27061	79640847
Hemiplegia	16.44	10.04	41	76439	14898	79653010
Cognitive disorder	16.44	10.04	26	76454	69900	79598008
Insomnia	16.43	10.04	153	76327	245017	79422891
Euglycaemic diabetic ketoacidosis	16.36	10.04	26	76454	6818	79661090
Secretion discharge	16.29	10.04	41	76439	14981	79652927
Cold sweat	16.22	10.04	47	76433	18652	79649256
Drug hypersensitivity	16.20	10.04	196	76284	298720	79369188
Intensive care unit acquired weakness	16.16	10.04	14	76466	1919	79665989
Insulin C-peptide decreased	16.15	10.04	5	76475	72	79667836
Infection	16.13	10.04	151	76329	241561	79426347
Intercepted product dispensing error	16.11	10.04	6	76474	155	79667753
Blood creatinine increased	16.10	10.04	223	76257	154834	79513074
Psychotic disorder	15.92	10.04	10	76470	41392	79626516
Hospitalisation	15.89	10.04	149	76331	94087	79573821
Pseudomonal bacteraemia	15.70	10.04	17	76463	3065	79664843
Polydipsia	15.66	10.04	25	76455	6580	79661328
Underdose	15.50	10.04	68	76412	33083	79634825
Blood cholesterol increased	15.43	10.04	36	76444	83684	79584224
Mucosal dryness	15.34	10.04	18	76462	3541	79664367
Intraventricular haemorrhage	15.18	10.04	21	76459	4866	79663042
Enterococcus test positive	15.14	10.04	14	76466	2090	79665818
Nasopharyngitis	15.12	10.04	163	76317	253718	79414190
Bone marrow failure	15.11	10.04	16	76464	51091	79616817
C-reactive protein increased	15.05	10.04	68	76412	128959	79538949
Product monitoring error	14.99	10.04	29	76451	8877	79659031
Dawn phenomenon	14.91	10.04	3	76477	5	79667903
Neuroleptic malignant syndrome	14.88	10.04	4	76476	27555	79640353
Gastric disorder	14.72	10.04	73	76407	37360	79630548
Knee arthroplasty	14.60	10.04	12	76468	43236	79624672
Generalised oedema	14.60	10.04	53	76427	23656	79644252
Serotonin syndrome	14.58	10.04	13	76467	45014	79622894
Mucosal inflammation	14.33	10.04	32	76448	75548	79592360
Drug dependence	14.16	10.04	11	76469	40758	79627150
Urinary tract obstruction	14.10	10.04	20	76460	4745	79663163
Somogyi phenomenon	13.96	10.04	3	76477	8	79667900
Blood pressure fluctuation	13.94	10.04	27	76453	67118	79600790
Posterior reversible encephalopathy syndrome	13.85	10.04	4	76476	26277	79641631
Mouth ulceration	13.79	10.04	10	76470	38384	79629524
Tendonitis	13.77	10.04	3	76477	23827	79644081
Vascular parkinsonism	13.62	10.04	5	76475	124	79667784
Adenocarcinoma pancreas	13.62	10.04	13	76467	2020	79665888
Malnutrition	13.60	10.04	50	76430	22452	79645456
Acute myocardial infarction	13.59	10.04	123	76357	76913	79590995
Post streptococcal glomerulonephritis	13.55	10.04	5	76475	126	79667782
Product prescribing error	13.32	10.04	81	76399	44732	79623176
Leg amputation	13.31	10.04	17	76463	3649	79664259
Skin haemorrhage	13.31	10.04	33	76447	11948	79655960
Fibromyalgia	13.24	10.04	26	76454	64314	79603594
Expired product administered	13.17	10.04	24	76456	7027	79660881
Respiratory depression	13.16	10.04	5	76475	27625	79640283
Dry mouth	13.11	10.04	42	76438	87977	79579931
Fasting	13.09	10.04	4	76476	55	79667853
Hypoxia	13.05	10.04	154	76326	103089	79564819
Intercepted product selection error	13.04	10.04	3	76477	12	79667896
Extrapyramidal disorder	12.81	10.04	3	76477	22676	79645232
Enterobacter pneumonia	12.79	10.04	5	76475	148	79667760
Paraesthesia	12.70	10.04	108	76372	176215	79491693
Neck pain	12.67	10.04	34	76446	75383	79592525
Electrocardiogram abnormal	12.58	10.04	40	76440	16697	79651211
Device failure	12.57	10.04	22	76458	6239	79661669
Psoriatic arthropathy	12.49	10.04	36	76444	77963	79589945
Urinary tract infection	12.42	10.04	348	76132	274164	79393744
Blood ketone body increased	12.27	10.04	8	76472	714	79667194
Multiple sclerosis relapse	12.22	10.04	16	76464	46517	79621391
Diabetic complication	12.21	10.04	10	76470	1269	79666639
Hypercreatinaemia	12.18	10.04	6	76474	312	79667596
Urine ketone body present	12.11	10.04	16	76464	3549	79664359
Bursitis	12.03	10.04	10	76470	35834	79632074
Skin ulcer	11.99	10.04	91	76389	54059	79613849
Exposure during pregnancy	11.98	10.04	149	76331	100983	79566925
Chronic obstructive pulmonary disease	11.97	10.04	130	76350	85289	79582619
Varices oesophageal	11.97	10.04	21	76459	5970	79661938
Neutrophil count decreased	11.89	10.04	48	76432	93911	79573997
Basal cell carcinoma	11.86	10.04	11	76469	37364	79630544
Pancreatitis	11.85	10.04	109	76371	68466	79599442
Product quality issue	11.83	10.04	64	76416	33876	79634032
Dystonia	11.76	10.04	3	76477	21396	79646512
Urinary tract candidiasis	11.73	10.04	8	76472	769	79667139
Gastrointestinal haemorrhage	11.71	10.04	203	76277	147516	79520392
Chest pain	11.70	10.04	354	76126	281950	79385958
Peripheral arterial occlusive disease	11.66	10.04	25	76455	8233	79659675
Heart rate decreased	11.59	10.04	32	76448	70284	79597624
White blood cell count decreased	11.56	10.04	120	76360	188168	79479740
Migraine	11.52	10.04	44	76436	87449	79580459
Pancreatic carcinoma metastatic	11.47	10.04	16	76464	3737	79664171
Obstructive airways disorder	11.42	10.04	60	76420	31399	79636509
Listeraemia	11.39	10.04	4	76476	87	79667821
Somnolence	11.37	10.04	161	76319	238820	79429088
Sleep disorder	11.33	10.04	43	76437	85634	79582274
Vomiting	11.33	10.04	762	75718	665066	79002842
Visual acuity reduced	11.25	10.04	57	76423	29412	79638496
Pyelonephritis	11.24	10.04	44	76436	20344	79647564
Early satiety	11.19	10.04	10	76470	1429	79666479
Renal transplant	11.18	10.04	13	76467	2534	79665374
Dyskinesia	11.15	10.04	16	76464	44757	79623151
Pain	11.06	10.04	557	75923	703245	78964663
Blood ketone body present	10.94	10.04	4	76476	98	79667810
Myocardial infarction	10.87	10.04	242	76238	183887	79484021
Agitation	10.78	10.04	54	76426	99661	79568247
Hypoaesthesia	10.73	10.04	115	76365	179237	79488671
Gestational hypertension	10.70	10.04	11	76469	1868	79666040
Sedation	10.66	10.04	21	76459	51874	79616034
Cardiac disorder	10.60	10.04	103	76377	65654	79602254
Ischaemic stroke	10.57	10.04	61	76419	33070	79634838
Congestive hepatopathy	10.49	10.04	17	76463	4530	79663378
Insulin autoimmune syndrome	10.45	10.04	6	76474	426	79667482
Pulmonary oedema	10.44	10.04	130	76350	88124	79579784
Carbon dioxide abnormal	10.40	10.04	6	76474	430	79667478
Device expulsion	10.29	10.04	6	76474	25855	79642053
Ischaemic hepatitis	10.28	10.04	15	76465	3649	79664259
Hypoxic-ischaemic encephalopathy	10.28	10.04	23	76457	7797	79660111
Necrobiosis lipoidica diabeticorum	10.27	10.04	3	76477	35	79667873
Myocarditis	10.24	10.04	4	76476	21729	79646179
Pancreatitis acute	10.23	10.04	82	76398	49522	79618386
Aggression	10.14	10.04	21	76459	50937	79616971
Insulin C-peptide increased	10.12	10.04	4	76476	122	79667786
Itching scar	10.12	10.04	3	76477	37	79667871
Glycosylated haemoglobin decreased	10.06	10.04	7	76473	695	79667213

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A10AB04	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, fast-acting
ATC	A10AC04	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, intermediate-acting
ATC	A10AD04	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
FDA CS	M0011417	Insulin
FDA Chemical/Ingredient	N0000004931	Insulin
FDA EPC	N0000175453	Insulin Analog
CHEBI has role	CHEBI:35526	antidiabetic
FDA EPC	N0000175944	Insulin
MeSH PA	D007004	Hypoglycemic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Diabetes mellitus type 2	indication	44054006	DOID:9352
Diabetes mellitus type 1	indication	46635009	DOID:9744

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Insulin receptor	Kinase	P06213	INSR_HUMAN	AGONIST				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D04477	KEGG_DRUG
4020998	VUID
N0000179468	NUI
4017559	VANDF
4017569	VANDF
4019786	VANDF
4020998	VANDF
4021213	VANDF
CHEBI:5931	CHEBI
CHEMBL1201538	ChEMBL_ID
CHEMBL1201611	ChEMBL_ID
DB00046	DRUGBANK_ID
DB00030	DRUGBANK_ID
135805	RXNORM
283144	MMSL
335485	MMSL
4882	MMSL
4885	MMSL
4886	MMSL
6127	MMSL
8603	MMSL
d00262	MMSL
d04369	MMSL
d04373	MMSL
d04511	MMSL
000869	NDDF
000870	NDDF
006061	NDDF
006518	NDDF
007750	NDDF
126210001	SNOMEDCT_US
388454007	SNOMEDCT_US
412210000	SNOMEDCT_US
417423002	SNOMEDCT_US
420609005	SNOMEDCT_US
426313003	SNOMEDCT_US
96367001	SNOMEDCT_US
D061268	MESH_DESCRIPTOR_UI
C0293359	UMLSCUI
C0795635	UMLSCUI
7278	INN_ID
16132438	PUBCHEM_CID
5186	INN_ID
118984375	PUBCHEM_CID
GFX7QIS1II	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Humalog	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7510	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	34 sections
Humalog	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7510	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	34 sections
Humalog	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7510	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	34 sections
Humalog Mix75/25	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7511	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humalog Mix75/25	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7511	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humalog Mix50/50	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7512	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humalog Mix50/50	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7512	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humalog	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7516	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	34 sections
Humalog	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7516	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	34 sections
Humalog	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7516	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	34 sections
Humalog	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7533	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	34 sections
HumalogKwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7712	INJECTION, SOLUTION	200 [iU]	SUBCUTANEOUS	BLA	34 sections
HumalogKwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7712	INJECTION, SOLUTION	200 [iU]	SUBCUTANEOUS	BLA	34 sections
HumalogKwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7712	INJECTION, SOLUTION	200 [iU]	SUBCUTANEOUS	BLA	34 sections
Humalog Junior KwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7714	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	34 sections
Humalog Junior KwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7714	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	34 sections
Humalog Junior KwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7714	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	34 sections
LYUMJEV	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7726	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	34 sections
LYUMJEV	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7726	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	34 sections
LYUMJEV	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7726	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	34 sections
LYUMJEV	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7728	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	34 sections
LYUMJEV	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7728	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	34 sections
LYUMJEV	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7728	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	34 sections
Insulin Lispro	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7737	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	34 sections
Insulin Lispro	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7737	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	34 sections
Insulin Lispro	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7737	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	34 sections
Insulin Lispro Junior KwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7752	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	34 sections
Insulin Lispro Junior KwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7752	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	34 sections
Insulin Lispro Junior KwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7752	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	34 sections
LYUMJEV KwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-8207	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	34 sections