All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

insulin lispro 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	5002	133107-64-9

Description:

Molecule	Description
Synonyms: insulin lispro BS lyumjev insulin lispro protamine recombinant insulin lispro protamine insulin lispro humalog insulin lispro recombinant humalog lispro	Insulin that has been modified so that the B-chain contains a LYSINE at position 28 instead of a PROLINE and a PROLINE at position 29 instead of a LYSINE. It is used to manage BLOOD GLUCOSE levels in patients with TYPE 2 DIABETES. Molecular weight: 5807.63 Formula: C257H383N65O77S6 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 2299.07 ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
40	U	P
40	U	P
40	U	P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
March 25, 2020	PMDA	Eli Lilly Japan K.K.
June 14, 1996	FDA	LILLY
April 30, 1996	EMA	Eli Lilly Nederland B.V.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Blood glucose increased	3224.38	10.88	1540	68855	93706	90464346
Hypoglycaemia	1619.83	10.88	876	69519	68972	90489080
Blood glucose decreased	733.55	10.88	360	70035	23069	90534983
Diabetic ketoacidosis	701.94	10.88	354	70041	24053	90533999
Diabetes mellitus inadequate control	593.56	10.88	290	70105	18394	90539658
Hyperglycaemia	477.24	10.88	361	70034	50609	90507443
Blood glucose abnormal	415.55	10.88	184	70211	9308	90548744
Glycosylated haemoglobin increased	407.63	10.88	212	70183	15350	90542702
Gangrene	379.65	10.88	190	70205	12686	90545366
Eye haemorrhage	378.18	10.88	176	70219	10004	90548048
Arterial occlusive disease	365.04	10.88	183	70212	12263	90545789
Blood glucose fluctuation	338.84	10.88	133	70262	4950	90553102
Neurologic neglect syndrome	313.34	10.88	148	70247	8699	90549353
Carotid artery thrombosis	312.54	10.88	149	70246	8943	90549109
Incorrect dose administered	299.15	10.88	337	70058	78593	90479459
Adjustment disorder	289.33	10.88	144	70251	9498	90548554
Personality disorder	276.61	10.88	152	70243	12292	90545760
Cataract	254.94	10.88	297	70098	71795	90486257
Sensory loss	248.40	10.88	162	70233	17913	90540139
Angina pectoris	245.97	10.88	220	70175	38940	90519112
Hemiplegia	239.78	10.88	152	70243	16008	90542044
Wrong product administered	234.51	10.88	116	70279	7549	90550503
Glossodynia	229.83	10.88	4	70391	321775	90236277
Motor dysfunction	227.41	10.88	157	70238	19073	90538979
Systemic lupus erythematosus	225.61	10.88	14	70381	361882	90196170
Affect lability	224.33	10.88	152	70243	17911	90540141
Skin haemorrhage	221.48	10.88	161	70234	21219	90536833
Coordination abnormal	210.35	10.88	156	70239	21200	90536852
Sinus congestion	204.55	10.88	170	70225	27254	90530798
Multi-organ disorder	202.83	10.88	73	70322	2127	90555925
Sneezing	197.94	10.88	173	70222	29696	90528356
Eating disorder	196.98	10.88	168	70227	27905	90530147
Cerebrovascular accident	194.17	10.88	346	70049	123187	90434865
Accidental underdose	183.76	10.88	57	70338	1034	90557018
Respiratory tract congestion	182.12	10.88	159	70236	27251	90530801
Hemiparesis	180.76	10.88	169	70226	31650	90526402
Pericarditis	172.78	10.88	9	70386	270142	90287910
Sinus disorder	171.24	10.88	170	70225	34277	90523775
Drug intolerance	169.26	10.88	68	70327	447523	90110529
Abdominal discomfort	167.15	10.88	81	70314	477247	90080805
Hypoglycaemic coma	163.98	10.88	68	70327	2922	90555130
Aphasia	162.49	10.88	183	70212	42629	90515423
Diabetic retinopathy	160.28	10.88	65	70330	2637	90555415
Synovitis	160.03	10.88	31	70364	329721	90228331
Joint swelling	157.96	10.88	98	70297	503202	90054850
Helicobacter infection	153.60	10.88	5	70390	226845	90331207
Infusion related reaction	153.25	10.88	66	70329	416714	90141338
Hepatic enzyme increased	151.47	10.88	46	70349	360690	90197362
Treatment failure	150.84	10.88	27	70368	303901	90254151
Cardiac failure congestive	150.67	10.88	273	70122	98421	90459631
Contraindicated product administered	147.34	10.88	34	70361	320105	90237947
Alopecia	145.11	10.88	104	70291	494967	90063085
Folliculitis	144.00	10.88	3	70392	204350	90353702
Ketoacidosis	143.00	10.88	75	70320	5520	90552532
Muscle spasticity	139.21	10.88	154	70241	35168	90522884
Product storage error	135.64	10.88	118	70277	20123	90537929
Arthropathy	133.02	10.88	59	70336	366183	90191869
Rhinorrhoea	131.89	10.88	242	70153	88074	90469978
Cystitis	131.67	10.88	207	70188	66511	90491541
Dysarthria	128.89	10.88	184	70211	54298	90503754
Therapeutic product effect decreased	126.68	10.88	30	70365	277541	90280511
Irritable bowel syndrome	120.77	10.88	11	70384	207437	90350615
Lower respiratory tract infection	118.59	10.88	25	70370	250634	90307418
Insulin resistance	116.51	10.88	41	70354	1117	90556935
Off label use	115.97	10.88	453	69942	1101799	89456253
Skin exfoliation	115.47	10.88	197	70198	67716	90490336
Discomfort	113.30	10.88	36	70359	274299	90283753
Rash	108.03	10.88	292	70103	795808	89762244
Eye discharge	103.74	10.88	70	70325	8188	90549864
Blindness	103.26	10.88	115	70280	26453	90531599
Acute kidney injury	102.42	10.88	506	69889	319881	90238171
Hypoglycaemic unconsciousness	102.12	10.88	34	70361	780	90557272
Thyroid disorder	102.04	10.88	95	70300	17690	90540362
Arthralgia	101.57	10.88	291	70104	778231	89779821
Swelling	100.92	10.88	106	70289	418952	90139100
Diabetic retinal oedema	96.87	10.88	28	70367	394	90557658
Blood pressure increased	93.49	10.88	351	70044	196866	90361186
Nasal obstruction	93.42	10.88	44	70351	2568	90555484
Stomatitis	92.47	10.88	49	70346	274649	90283403
Malnutrition	91.13	10.88	91	70304	18467	90539585
Psoriatic arthropathy	90.71	10.88	32	70363	228303	90329749
Musculoskeletal stiffness	88.49	10.88	61	70334	296471	90261581
Blister	88.04	10.88	44	70351	254954	90303098
Arthritis	87.09	10.88	307	70088	167008	90391044
Mobility decreased	86.97	10.88	43	70352	250691	90307361
Palpitations	84.61	10.88	266	70129	136462	90421590
Ill-defined disorder	84.29	10.88	20	70375	184871	90373181
Infective pulmonary exacerbation of cystic fibrosis	83.53	10.88	67	70328	10212	90547840
Product dispensing error	83.14	10.88	72	70323	12201	90545851
Fall	82.52	10.88	648	69747	481162	90076890
Influenza	81.69	10.88	266	70129	138998	90419054
Hypoglycaemic seizure	80.79	10.88	26	70369	534	90557518
Throat clearing	77.34	10.88	44	70351	3803	90554249
Wound	77.07	10.88	73	70322	302907	90255145
Liver injury	74.76	10.88	20	70375	170547	90387505
Influenza like illness	73.85	10.88	181	70214	80430	90477622
Hypoglycaemia unawareness	70.78	10.88	17	70378	109	90557943
Bursitis	69.07	10.88	10	70385	131644	90426408
Dysphagia	69.06	10.88	218	70177	112060	90445992
Visual acuity reduced	68.98	10.88	88	70307	23322	90534730
Product complaint	67.77	10.88	67	70328	13433	90544619
Pulmonary oedema	67.39	10.88	149	70246	61931	90496121
Blood cholesterol increased	67.25	10.88	39	70356	207973	90350079
Insulin C-peptide decreased	66.64	10.88	14	70381	43	90558009
Fibromyalgia	66.22	10.88	39	70356	206230	90351822
C-reactive protein abnormal	66.11	10.88	10	70385	127419	90430633
Product dose omission issue	65.45	10.88	419	69976	291268	90266784
Joint range of motion decreased	65.22	10.88	13	70382	135630	90422422
Intercepted product selection error	64.67	10.88	12	70383	14	90558038
Chest discomfort	64.49	10.88	245	70150	138120	90419932
Type 2 diabetes mellitus	63.05	10.88	40	70355	203204	90354848
Impaired healing	62.44	10.88	54	70341	234145	90323907
Renal failure	61.91	10.88	233	70162	130774	90427278
Increased insulin requirement	60.42	10.88	14	70381	75	90557977
Diabetic neuropathy	60.41	10.88	40	70355	4534	90553518
Expired product administered	60.29	10.88	47	70348	6875	90551177
Lip dry	59.69	10.88	5	70390	100950	90457102
Injury associated with device	56.46	10.88	38	70357	4426	90553626
Product administration error	54.93	10.88	84	70311	26339	90531713
Underdose	54.56	10.88	126	70269	53891	90504161
Hypersensitivity	54.12	10.88	177	70218	454500	90103552
Loss of consciousness	53.96	10.88	234	70161	140004	90418048
Dry mouth	52.09	10.88	40	70355	184019	90374033
Intentional product use issue	51.99	10.88	55	70340	216837	90341215
Blood insulin increased	51.76	10.88	14	70381	152	90557900
Type 1 diabetes mellitus	51.57	10.88	37	70358	4775	90553277
Anti-insulin antibody increased	50.93	10.88	11	70384	40	90558012
Neuropathy peripheral	50.01	10.88	225	70170	136745	90421307
Sleep disorder	48.84	10.88	49	70346	197981	90360071
Injury	48.48	10.88	49	70346	197300	90360752
Product use issue	47.67	10.88	117	70278	329802	90228250
Intercepted product dispensing error	47.66	10.88	13	70382	146	90557906
Anti-insulin antibody positive	47.00	10.88	12	70383	102	90557950
Drug hypersensitivity	45.69	10.88	195	70200	463414	90094638
Pericardial effusion	45.27	10.88	93	70302	36740	90521312
Pre-eclampsia	44.96	10.88	49	70346	10999	90547053
Pulmonary fibrosis	44.54	10.88	14	70381	107489	90450563
Toxicity to various agents	44.04	10.88	99	70296	287747	90270305
Prescribed overdose	43.62	10.88	11	70384	97614	90460438
Product use in unapproved indication	43.46	10.88	126	70269	336110	90221942
Night sweats	43.25	10.88	23	70372	128743	90429309
Diabetic foot	42.07	10.88	22	70373	1609	90556443
Inflammation	42.01	10.88	46	70349	178546	90379506
Hypoaesthesia	41.15	10.88	117	70278	314093	90243959
Diabetes mellitus	40.83	10.88	127	70268	64748	90493304
Peripheral swelling	40.54	10.88	174	70221	412932	90145120
Hypoglycaemia neonatal	40.43	10.88	19	70376	1103	90556949
Peripheral venous disease	40.43	10.88	8	70387	83913	90474139
Insomnia	40.22	10.88	129	70266	333345	90224707
Hip arthroplasty	39.48	10.88	6	70389	76202	90481850
Eye pruritus	38.92	10.88	76	70319	28951	90529101
Wound infection	38.79	10.88	17	70378	106385	90451667
Visual impairment	38.67	10.88	204	70191	132161	90425891
Grip strength decreased	38.45	10.88	12	70383	92564	90465488
Secretion discharge	38.04	10.88	54	70341	15842	90542210
Pseudomonal bacteraemia	37.93	10.88	22	70373	1972	90556080
Migraine	37.57	10.88	56	70339	190336	90367716
Anti-insulin antibody	37.50	10.88	8	70387	27	90558025
Drug ineffective	37.46	10.88	806	69589	1383492	89174560
Shock hypoglycaemic	37.02	10.88	10	70385	108	90557944
Myocardial infarction	36.39	10.88	171	70224	105801	90452251
Large for dates baby	36.07	10.88	14	70381	505	90557547
Hyperkalaemia	35.32	10.88	121	70274	64843	90493209
Scleroedema	35.32	10.88	10	70385	130	90557922
Wrong technique in product usage process	35.22	10.88	129	70266	71442	90486610
C-reactive protein increased	35.16	10.88	54	70341	181335	90376717
Insulinoma	35.11	10.88	10	70385	133	90557919
Knee arthroplasty	34.16	10.88	11	70384	83171	90474881
Red blood cell sedimentation rate increased	33.78	10.88	11	70384	82584	90475468
Lung disorder	33.73	10.88	40	70355	149843	90408209
Dyspnoea exertional	33.66	10.88	128	70267	72160	90485892
Contusion	33.29	10.88	93	70302	251123	90306929
Gait inability	33.05	10.88	39	70356	146417	90411635
Transcription medication error	32.89	10.88	11	70384	256	90557796
Infection	32.83	10.88	157	70238	361937	90196115
Chronic kidney disease	32.27	10.88	99	70296	50092	90507960
Autoimmune disorder	31.78	10.88	10	70385	76734	90481318
Nausea	31.72	10.88	1105	69290	1109211	89448841
Sciatica	31.36	10.88	20	70375	101362	90456690
Hypercholesterolaemia	31.08	10.88	20	70375	100872	90457180
Acute respiratory failure	30.78	10.88	88	70307	42830	90515222
Diabetic complication	30.58	10.88	15	70380	958	90557094
Transient tachypnoea of the newborn	30.54	10.88	9	70386	136	90557916
Pancreatic carcinoma	30.40	10.88	35	70360	8342	90549710
Coronary artery disease	30.25	10.88	75	70320	33548	90524504
Sopor	30.02	10.88	62	70333	24582	90533470
Diabetic nephropathy	30.02	10.88	18	70377	1716	90556336
Endometrial disorder	29.88	10.88	14	70381	807	90557245
Psoriasis	29.33	10.88	206	70189	147548	90410504
Adverse drug reaction	28.62	10.88	29	70366	116672	90441380
Myelosuppression	28.27	10.88	4	70391	53587	90504465
Nail disorder	27.69	10.88	6	70389	59061	90498991
Lupus-like syndrome	27.34	10.88	3	70392	48843	90509209
Premature delivery	27.33	10.88	79	70316	38683	90519369
Ischaemic stroke	27.28	10.88	56	70339	22110	90535942
Epilepsy	27.14	10.88	15	70380	82191	90475861
Intensive care unit acquired weakness	27.12	10.88	14	70381	997	90557055
Sepsis	27.01	10.88	235	70160	179579	90378473
Renal tubular disorder	26.26	10.88	21	70374	3186	90554866
Keratitis	26.12	10.88	23	70372	3983	90554069
Euglycaemic diabetic ketoacidosis	26.10	10.88	28	70367	6173	90551879
Croup infectious	25.89	10.88	12	70383	675	90557377
Urinary tract infection	25.75	10.88	356	70039	305276	90252776
Urinary tract obstruction	25.73	10.88	18	70377	2231	90555821
Ventricular septal defect	25.60	10.88	26	70369	5381	90552671
Rhonchi	25.46	10.88	20	70375	2958	90555094
Vitreous haemorrhage	25.44	10.88	19	70376	2607	90555445
Epileptic encephalopathy	25.30	10.88	10	70385	379	90557673
Diabetic coma	25.01	10.88	12	70383	730	90557322
Cutaneous amyloidosis	24.70	10.88	5	70390	12	90558040
Chronic obstructive pulmonary disease	24.52	10.88	118	70277	73711	90484341
Device operational issue	24.29	10.88	13	70382	997	90557055
Urticaria	24.22	10.88	143	70252	312591	90245461
Dopamine transporter scintigraphy abnormal	24.18	10.88	7	70388	99	90557953
Cellulitis	24.13	10.88	137	70258	91200	90466852
Live birth	23.93	10.88	16	70379	79091	90478961
Disease progression	23.83	10.88	54	70341	156561	90401491
Bone erosion	23.64	10.88	6	70389	53015	90505037
Anaemia	23.56	10.88	395	70000	352407	90205645
Enterococcus test positive	23.54	10.88	14	70381	1315	90556737
Lower limb fracture	23.38	10.88	19	70376	84994	90473058
Joint stiffness	23.32	10.88	16	70379	78026	90480026
Generalised oedema	23.29	10.88	48	70347	19005	90539047
Medical device site abscess	23.27	10.88	8	70387	203	90557849
Dyspepsia	22.94	10.88	78	70317	198082	90359970
Medical device site cellulitis	22.73	10.88	8	70387	218	90557834
Pertussis	22.73	10.88	12	70383	895	90557157
Cystic fibrosis	22.50	10.88	21	70374	3920	90554132
Blood ketone body increased	22.50	10.88	9	70386	352	90557700
Infusion site pain	22.12	10.88	48	70347	19690	90538362
Hyperinsulinaemic hypoglycaemia	22.12	10.88	7	70388	136	90557916
Renal impairment	22.11	10.88	149	70246	105272	90452780
Neck pain	22.01	10.88	34	70361	113929	90444123
Non-cardiogenic pulmonary oedema	21.95	10.88	13	70382	1211	90556841
Dehydration	21.78	10.88	239	70156	194208	90363844
Small for dates baby	21.77	10.88	23	70372	4984	90553068
Patella fracture	21.57	10.88	17	70378	2526	90555526
Malignant neoplasm progression	21.50	10.88	31	70364	106839	90451213
Blood ketone body	21.34	10.88	6	70389	76	90557976
Treatment noncompliance	21.19	10.88	88	70307	51639	90506413
Congestive hepatopathy	20.96	10.88	18	70377	3015	90555037
Osteoarthritis	20.70	10.88	80	70315	195650	90362402
Retinopathy	20.51	10.88	19	70376	3515	90554537
Diabetic hyperglycaemic coma	20.31	10.88	5	70390	36	90558016
Exostosis	20.15	10.88	8	70387	53126	90504926
Therapeutic product effect incomplete	20.03	10.88	80	70315	193816	90364236
Foetal exposure during pregnancy	19.92	10.88	76	70319	42899	90515153
Condition aggravated	19.92	10.88	334	70061	595211	89962841
Paraesthesia	19.62	10.88	114	70281	250212	90307840
Asthenia	19.60	10.88	548	69847	533203	90024849
Peritonitis bacterial	19.43	10.88	22	70373	5149	90552903
Antibody test negative	19.43	10.88	5	70390	44	90558008
Urine ketone body present	19.40	10.88	16	70379	2536	90555516
Cough	19.38	10.88	398	69997	368564	90189488
Electrolyte imbalance	19.32	10.88	51	70344	23694	90534358
Pancreatic disorder	19.26	10.88	17	70378	2954	90555098
Onychomycosis	19.23	10.88	3	70392	37373	90520679
Vomiting	19.17	10.88	771	69624	787522	89770530
Prescribed underdose	19.14	10.88	18	70377	75001	90483051
Laryngitis	18.67	10.88	8	70387	50745	90507307
Rubella antibody negative	18.48	10.88	3	70392	0	90558052
Neuropathic arthropathy	18.41	10.88	8	70387	386	90557666
Drug-induced liver injury	18.36	10.88	26	70369	90292	90467760
Adverse event	18.25	10.88	40	70355	117378	90440674
Obesity	18.06	10.88	34	70361	105473	90452579
Hypoacusis	17.96	10.88	55	70340	27795	90530257
Impaired gastric emptying	17.74	10.88	34	70361	12775	90545277
Fasting	17.66	10.88	4	70391	19	90558033
Renal disorder	17.59	10.88	67	70328	37792	90520260
Anxiety	17.55	10.88	338	70057	309434	90248618
Obstructive airways disorder	17.55	10.88	52	70343	25817	90532235
Completed suicide	17.54	10.88	56	70339	145002	90413050
Caesarean section	17.31	10.88	42	70353	18535	90539517
Muscle spasms	17.03	10.88	120	70275	251763	90306289
Exposure via eye contact	17.03	10.88	4	70391	23	90558029
Wrong patient received product	16.98	10.88	17	70378	3460	90554592
Gestational hypertension	16.88	10.88	16	70379	3046	90555006
Intercepted product prescribing error	16.87	10.88	7	70388	301	90557751
Loss of personal independence in daily activities	16.84	10.88	52	70343	136053	90421999
Delirium	16.68	10.88	35	70360	104324	90453728
Blindness unilateral	16.65	10.88	25	70370	7711	90550341
Blindness transient	16.52	10.88	19	70376	4524	90553528
Eye irritation	16.51	10.88	61	70334	33917	90524135
Road traffic accident	16.46	10.88	37	70358	107589	90450463
Pruritus	16.42	10.88	309	70086	541216	90016836
Therapy non-responder	16.38	10.88	53	70342	136651	90421401
Dermatitis bullous	16.32	10.88	29	70366	10287	90547765
Lactic acidosis	16.28	10.88	80	70315	50383	90507669
Localised infection	16.09	10.88	60	70335	33502	90524550
End stage renal disease	16.08	10.88	26	70369	8545	90549507
Dawn phenomenon	15.95	10.88	3	70392	4	90558048
Peripheral sensorimotor neuropathy	15.92	10.88	13	70382	2032	90556020
Mitral valve stenosis	15.84	10.88	11	70384	1348	90556704
Drug tolerance decreased	15.61	10.88	3	70392	32127	90525925
Ketosis	15.59	10.88	9	70386	800	90557252
Chest pain	15.55	10.88	341	70054	319304	90238748
Frequent bowel movements	15.32	10.88	13	70382	56922	90501130
Exposure during pregnancy	15.20	10.88	265	70130	238145	90319907
Foetal hypokinesia	14.88	10.88	8	70387	619	90557433
Cardiac hypertrophy	14.83	10.88	10	70385	1168	90556884
Type III immune complex mediated reaction	14.74	10.88	7	70388	416	90557636
Myalgia	14.73	10.88	204	70191	174921	90383131
Vascular parkinsonism	14.73	10.88	5	70390	122	90557930
Urosepsis	14.71	10.88	43	70352	21189	90536863
Back injury	14.69	10.88	9	70386	46613	90511439
Pallor	14.69	10.88	59	70336	34106	90523946
Pyelonephritis	14.60	10.88	43	70352	21273	90536779
Hospitalisation	14.59	10.88	158	70237	127942	90430110
Product prescribing error	14.55	10.88	54	70341	30091	90527961
Glomerular filtration rate decreased	14.43	10.88	37	70358	16895	90541157
Hypervolaemia	14.43	10.88	57	70338	32700	90525352
Muscular weakness	14.38	10.88	233	70162	206433	90351619
Diabetic metabolic decompensation	14.32	10.88	12	70383	1945	90556107
Device expulsion	14.18	10.88	7	70388	40879	90517173
Cardiac disorder	14.17	10.88	84	70311	56788	90501264
Pneumonia	14.11	10.88	618	69777	637441	89920611
Arteriosclerosis	14.04	10.88	28	70367	10825	90547227
Pain	14.03	10.88	632	69763	995709	89562343
Rectal haemorrhage	13.86	10.88	27	70368	82717	90475335
Hepatitis	13.76	10.88	21	70374	70718	90487334
Incorrect product dosage form administered	13.66	10.88	5	70390	153	90557899
Gastrointestinal haemorrhage	13.57	10.88	118	70277	90130	90467922
Inflammatory marker increased	13.43	10.88	25	70370	9189	90548863
Musculoskeletal pain	13.41	10.88	78	70317	171173	90386879
Nerve compression	13.36	10.88	27	70368	10539	90547513
Poor quality product administered	13.31	10.88	16	70379	3992	90554060
Anuria	13.27	10.88	33	70362	14785	90543267
White blood cell count decreased	13.14	10.88	76	70319	167033	90391019
Liver function test increased	13.11	10.88	29	70366	84826	90473226
Thyroid cancer	13.09	10.88	20	70375	6264	90551788
Listeraemia	12.98	10.88	4	70391	71	90557981
Cardiac death	12.56	10.88	7	70388	581	90557471
Full blood count abnormal	12.52	10.88	59	70336	36538	90521514
Adenocarcinoma pancreas	12.50	10.88	9	70386	1167	90556885
Blood potassium increased	12.48	10.88	40	70355	20709	90537343
Flank pain	12.43	10.88	38	70357	19184	90538868
Depression	12.31	10.88	162	70233	300439	90257613
Hypertriglyceridaemia	12.25	10.88	22	70373	7867	90550185
Wheezing	12.21	10.88	122	70273	237958	90320094
Coronary artery occlusion	12.21	10.88	23	70372	8531	90549521
Syncope	12.18	10.88	157	70238	132506	90425546
Premature baby	12.16	10.88	45	70350	25032	90533020
Injection site pain	12.14	10.88	196	70199	173503	90384549
Anaemia of malignant disease	12.07	10.88	7	70388	627	90557425
Radiation overdose	11.91	10.88	3	70392	24	90558028
Tachypnoea	11.85	10.88	40	70355	21269	90536783
Myelopathy	11.85	10.88	14	70381	3430	90554622
Gastroschisis	11.83	10.88	6	70389	412	90557640
Toe amputation	11.77	10.88	11	70384	2058	90555994
Polyhydramnios	11.77	10.88	12	70383	2496	90555556
Amnesia	11.69	10.88	44	70351	108461	90449591
Micturition disorder	11.61	10.88	13	70382	3007	90555045
Maternal drugs affecting foetus	11.59	10.88	17	70378	5138	90552914
Taste disorder	11.28	10.88	19	70376	61527	90496525
Heart rate decreased	11.28	10.88	15	70380	53490	90504562
Amputation	11.18	10.88	5	70390	259	90557793
Pancreatic cyst	11.15	10.88	11	70384	2199	90555853
Mental status changes	11.14	10.88	66	70329	44613	90513439
Food allergy	11.13	10.88	3	70392	25475	90532577
Polydipsia	11.06	10.88	15	70380	4216	90553836
Clostridium test positive	10.98	10.88	17	70378	5384	90552668
Ascites	10.94	10.88	69	70326	47671	90510381
Postprandial hypoglycaemia	10.91	10.88	4	70391	123	90557929
Malaise	10.91	10.88	558	69837	585428	89972624

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Blood glucose increased	2107.58	10.97	1219	48714	72480	42498922
Hypoglycaemia	1334.47	10.97	845	49088	59009	42512393
Blood glucose decreased	479.95	10.97	263	49670	13956	42557446
Diabetic ketoacidosis	412.51	10.97	281	49652	22086	42549316
Hyperglycaemia	404.51	10.97	373	49560	45486	42525916
Diabetes mellitus inadequate control	389.45	10.97	236	49697	15154	42556248
Blood glucose abnormal	331.56	10.97	163	49770	6890	42564512
Glycosylated haemoglobin increased	316.25	10.97	194	49739	12730	42558672
Incorrect dose administered	229.03	10.97	296	49637	52678	42518724
Hypoglycaemic coma	180.42	10.97	80	49853	2664	42568738
Wrong product administered	177.10	10.97	103	49830	6123	42565279
Hypoglycaemic unconsciousness	166.94	10.97	54	49879	730	42570672
Blood glucose fluctuation	144.18	10.97	81	49852	4506	42566896
Accidental underdose	133.90	10.97	44	49889	627	42570775
Anti-insulin antibody positive	132.72	10.97	33	49900	154	42571248
Toxicity to various agents	122.02	10.97	58	49875	229078	42342324
Product storage error	114.72	10.97	99	49834	11041	42560361
Off label use	97.52	10.97	402	49531	637933	41933469
Diabetic retinopathy	94.92	10.97	47	49886	2016	42569386
Intercepted product selection error	86.00	10.97	17	49916	17	42571385
Ketoacidosis	84.08	10.97	61	49872	5291	42566111
Underdose	78.08	10.97	97	49836	16569	42554833
Hypoglycaemic seizure	70.88	10.97	24	49909	377	42571025
Diabetic metabolic decompensation	65.73	10.97	37	49896	2065	42569337
Product dispensing error	59.37	10.97	58	49875	7581	42563821
Drug abuse	58.06	10.97	25	49908	104746	42466656
Foetal disorder	56.93	10.97	27	49906	1052	42570350
Hypoglycaemia unawareness	55.74	10.97	16	49917	140	42571262
Acute kidney injury	55.31	10.97	665	49268	366672	42204730
Insulin resistance	54.40	10.97	24	49909	789	42570613
Diabetic neuropathy	52.52	10.97	43	49890	4459	42566943
Infusion site pain	51.64	10.97	46	49887	5349	42566053
Product complaint	47.61	10.97	46	49887	5931	42565471
Infective pulmonary exacerbation of cystic fibrosis	47.48	10.97	52	49881	7766	42563636
Neutropenia neonatal	45.44	10.97	22	49911	898	42570504
Blindness	43.91	10.97	77	49856	17901	42553501
Cutaneous amyloidosis	41.87	10.97	10	49923	38	42571364
Anti-insulin antibody increased	41.65	10.97	11	49922	68	42571334
Anti-insulin antibody	39.07	10.97	9	49924	28	42571374
Intercepted product dispensing error	37.85	10.97	11	49922	101	42571301
Visual impairment	37.04	10.97	123	49810	42990	42528412
Hyperkalaemia	36.14	10.97	188	49745	80270	42491132
Wrong technique in product usage process	36.06	10.97	121	49812	42514	42528888
Completed suicide	35.89	10.97	36	49897	96429	42474973
Impaired gastric emptying	35.53	10.97	34	49899	4332	42567070
Pancreatic carcinoma	34.75	10.97	49	49884	9457	42561945
Product use in unapproved indication	34.72	10.97	106	49827	184350	42387052
Retinopathy	33.58	10.97	25	49908	2256	42569146
Dehydration	32.98	10.97	281	49652	141486	42429916
Diabetic coma	32.33	10.97	18	49915	983	42570419
Ketosis	31.23	10.97	17	49916	888	42570514
Myelosuppression	31.17	10.97	5	49928	40456	42530946
Cardiac failure congestive	31.14	10.97	189	49744	85413	42485989
Product dose omission issue	30.82	10.97	296	49637	154069	42417333
Type 1 diabetes mellitus	30.75	10.97	35	49898	5452	42565950
Systemic infection	30.53	10.97	34	49899	5171	42566231
Disease progression	30.40	10.97	78	49855	143578	42427824
Left atrial dilatation	30.26	10.97	24	49909	2378	42569024
Sopor	30.26	10.97	55	49878	13147	42558255
Treatment failure	30.11	10.97	18	49915	62606	42508796
Toe amputation	30.09	10.97	26	49907	2903	42568499
Febrile neutropenia	29.99	10.97	114	49819	185589	42385813
Diabetic foot	29.01	10.97	26	49907	3047	42568355
Diabetic foot infection	28.52	10.97	15	49918	731	42570671
Skin ulcer	28.50	10.97	80	49853	25521	42545881
Diabetic gastroparesis	28.43	10.97	9	49924	113	42571289
Multiple organ dysfunction syndrome	27.97	10.97	44	49889	96991	42474411
Increased insulin requirement	27.09	10.97	9	49924	133	42571269
Haematocrit increased	26.80	10.97	23	49910	2544	42568858
Shock hypoglycaemic	26.74	10.97	8	49925	82	42571320
Hypoaldosteronism	26.48	10.97	11	49922	311	42571091
Diaphragmatic disorder	26.28	10.97	17	49916	1222	42570180
Mucosal dryness	26.07	10.97	19	49914	1659	42569743
Visual acuity reduced	25.91	10.97	61	49872	17489	42553913
Expired product administered	25.82	10.97	28	49905	4135	42567267
Oedematous pancreatitis	25.45	10.97	14	49919	747	42570655
Loss of consciousness	24.69	10.97	189	49744	92165	42479237
Product monitoring error	24.43	10.97	28	49905	4395	42567007
Insulin autoimmune syndrome	24.10	10.97	12	49921	521	42570881
Drug ineffective for unapproved indication	24.03	10.97	12	49921	46151	42525251
Medication error	23.66	10.97	89	49844	33065	42538337
Cerebrovascular accident	23.33	10.97	194	49739	96966	42474436
Mumps antibody test negative	23.00	10.97	4	49929	0	42571402
Meningomyelocele	22.85	10.97	9	49924	221	42571181
Premature baby	22.57	10.97	69	49864	23084	42548318
Diabetic nephropathy	22.48	10.97	20	49913	2321	42569081
Leg amputation	22.44	10.97	21	49912	2602	42568800
Haemoglobin increased	22.32	10.97	29	49904	5177	42566225
Oedema peripheral	21.98	10.97	250	49683	135826	42435576
Amylase decreased	21.96	10.97	7	49926	90	42571312
Acetonaemia	21.75	10.97	9	49924	252	42571150
Road traffic accident	21.58	10.97	60	49873	19033	42552369
Device operational issue	21.48	10.97	9	49924	260	42571142
Congenital multiplex arthrogryposis	21.36	10.97	9	49924	264	42571138
Mucosal inflammation	21.30	10.97	16	49917	49358	42522044
Pseudolymphoma	21.26	10.97	12	49921	673	42570729
Localised infection	21.07	10.97	62	49871	20311	42551091
Drug resistance	20.91	10.97	7	49926	34241	42537161
VACTERL syndrome	20.85	10.97	6	49927	53	42571349
Renal disorder	20.85	10.97	78	49855	28902	42542500
Infusion site induration	20.68	10.97	10	49923	407	42570995
Fall	20.11	10.97	386	49547	234134	42337268
Hypoglycaemic encephalopathy	19.93	10.97	9	49924	313	42571089
Cold sweat	19.66	10.97	42	49891	11288	42560114
Neutropenia	19.55	10.97	145	49788	199286	42372116
Osteomyelitis	19.36	10.97	56	49877	18167	42553235
Hospitalisation	19.24	10.97	151	49782	74179	42497223
Loss of personal independence in daily activities	19.21	10.97	18	49915	49798	42521604
Malignant neoplasm progression	19.18	10.97	64	49869	108336	42463066
Sedation	19.01	10.97	6	49927	30469	42540933
Acute respiratory failure	18.98	10.97	93	49840	38765	42532637
Intentional product use issue	18.47	10.97	35	49898	71798	42499604
Immunosuppressant drug level decreased	18.35	10.97	16	49917	1808	42569594
Weight increased	18.17	10.97	200	49733	107783	42463619
Hypervolaemia	18.12	10.97	64	49869	23061	42548341
Somnolence	17.74	10.97	95	49838	141010	42430392
Chronic kidney disease	17.61	10.97	105	49828	47136	42524266
Peritonitis bacterial	17.38	10.97	30	49903	6885	42564517
Measles antibody negative	17.25	10.97	3	49930	0	42571402
Rubella antibody negative	17.25	10.97	3	49930	0	42571402
Rash	17.20	10.97	225	49708	276729	42294673
Poor quality product administered	16.96	10.97	17	49916	2291	42569111
Lower respiratory tract infection	16.96	10.97	14	49919	41192	42530210
Cellulitis	16.43	10.97	126	49807	61459	42509943
Blood ketone body	16.24	10.97	6	49927	123	42571279
Pulmonary embolism	15.89	10.97	79	49854	119533	42451869
Balanoposthitis	15.87	10.97	14	49919	1607	42569795
Pseudohyponatraemia	15.80	10.97	6	49927	133	42571269
Intraventricular haemorrhage	15.67	10.97	21	49912	3863	42567539
Injury associated with device	15.58	10.97	13	49920	1384	42570018
Hemivertebra	15.48	10.97	6	49927	141	42571261
Joint swelling	15.10	10.97	36	49897	67986	42503416
Musculoskeletal stiffness	14.98	10.97	28	49905	57737	42513665
Diabetic wound	14.92	10.97	5	49928	76	42571326
Drug intolerance	14.56	10.97	47	49886	80377	42491025
Cytomegalovirus infection	14.55	10.97	10	49923	32296	42539106
Liquid product physical issue	14.51	10.97	10	49923	799	42570603
Syncope	14.44	10.97	179	49754	99227	42472175
Agitation	14.31	10.97	34	49899	64280	42507122
Therapy partial responder	14.29	10.97	3	49930	20018	42551384
Product name confusion	14.24	10.97	5	49928	88	42571314
Lipohypertrophy	14.23	10.97	7	49926	296	42571106
Injection site nodule	14.22	10.97	15	49918	2146	42569256
Atrial fibrillation	14.15	10.97	236	49697	139357	42432045
Arthralgia	14.14	10.97	163	49770	205075	42366327
Foot amputation	13.99	10.97	10	49923	847	42570555
Microalbuminuria	13.81	10.97	10	49923	864	42570538
Varices oesophageal	13.78	10.97	21	49912	4344	42567058
Neutrophil count decreased	13.73	10.97	34	49899	63381	42508021
Insulin C-peptide increased	13.60	10.97	5	49928	101	42571301
Insulin C-peptide decreased	13.46	10.97	4	49929	40	42571362
Cataract	13.38	10.97	71	49862	30533	42540869
Meningitis aseptic	13.36	10.97	21	49912	4461	42566941
Hepatic encephalopathy	13.31	10.97	46	49887	16396	42555006
Respiratory depression	13.12	10.97	3	49930	18865	42552537
Post streptococcal glomerulonephritis	13.04	10.97	5	49928	114	42571288
Treatment noncompliance	12.95	10.97	82	49851	37590	42533812
Incorrect product formulation administered	12.72	10.97	4	49929	49	42571353
Presyncope	12.72	10.97	56	49877	22331	42549071
Erythema	12.71	10.97	75	49858	108718	42462684
Diabetic complication	12.66	10.97	9	49924	756	42570646
Glycogen storage disease type VIII	12.44	10.97	3	49930	12	42571390
Impaired insulin secretion	12.44	10.97	3	49930	12	42571390
Condition aggravated	12.37	10.97	223	49710	260531	42310871
Diabetes mellitus	12.35	10.97	116	49817	59971	42511431
Pyrexia	12.22	10.97	360	49573	393682	42177720
Eye haemorrhage	12.20	10.97	21	49912	4809	42566593
Trigger finger	12.17	10.97	10	49923	1042	42570360
Lymphopenia	12.17	10.97	5	49928	21558	42549844
Subarachnoid haemorrhage	12.17	10.97	41	49892	14431	42556971
Oedematous kidney	12.04	10.97	4	49929	59	42571343
Psychotic disorder	11.92	10.97	10	49923	29198	42542204
Sleep disorder	11.87	10.97	24	49909	48071	42523331
Blindness unilateral	11.78	10.97	22	49911	5366	42566036
Stomatitis	11.69	10.97	26	49907	50303	42521099
Retrognathia	11.65	10.97	6	49927	280	42571122
Serotonin syndrome	11.64	10.97	8	49925	25837	42545565
Epididymitis	11.63	10.97	16	49917	3018	42568384
C-reactive protein increased	11.60	10.97	37	49896	63523	42507879
Injection site pain	11.59	10.97	111	49822	57687	42513715
Malaise	11.59	10.97	328	49605	211828	42359574
Bone marrow failure	11.57	10.97	13	49920	33080	42538322
Pancreatitis acute	11.50	10.97	73	49860	33491	42537911
Clostridium test positive	11.45	10.97	22	49911	5483	42565919
Cystic fibrosis	11.33	10.97	13	49920	2042	42569360
Hydrops foetalis	11.31	10.97	9	49924	896	42570506
Vitreous haemorrhage	11.31	10.97	15	49918	2732	42568670
Blood ketone body present	11.21	10.97	4	49929	74	42571328
Pancreatic carcinoma metastatic	11.10	10.97	16	49917	3150	42568252
Impaired fasting glucose	11.00	10.97	6	49927	315	42571087
Extra dose administered	10.99	10.97	22	49911	5647	42565755

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoglycaemia	2551.63	10.54	1466	95785	114638	110377410
Blood glucose increased	2487.52	10.54	1511	95740	130985	110361063
Diabetic ketoacidosis	811.56	10.54	489	96762	41569	110450479
Diabetes mellitus inadequate control	753.14	10.54	413	96838	29362	110462686
Blood glucose decreased	704.66	10.54	394	96857	29094	110462954
Hyperglycaemia	704.51	10.54	590	96661	84500	110407548
Glycosylated haemoglobin increased	461.68	10.54	277	96974	23342	110468706
Gangrene	351.76	10.54	204	97047	16137	110475911
Arterial occlusive disease	321.30	10.54	188	97063	15120	110476928
Blood glucose fluctuation	303.13	10.54	144	97107	7554	110484494
Carotid artery thrombosis	298.25	10.54	153	97098	9485	110482563
Neurologic neglect syndrome	297.60	10.54	151	97100	9147	110482901
Blood glucose abnormal	296.08	10.54	168	97083	12748	110479300
Hypoglycaemic coma	285.70	10.54	125	97126	5408	110486640
Adjustment disorder	270.85	10.54	149	97102	10646	110481402
Personality disorder	265.06	10.54	156	97095	12681	110479367
Sensory loss	216.12	10.54	167	97084	21290	110470758
Hemiplegia	211.53	10.54	169	97082	22613	110469435
Affect lability	209.74	10.54	155	97096	18482	110473566
Skin haemorrhage	207.04	10.54	173	97078	24654	110467394
Angina pectoris	203.03	10.54	262	96989	62033	110430015
Ketoacidosis	186.02	10.54	114	97137	9973	110482075
Acute kidney injury	184.60	10.54	1069	96182	634361	109857687
Systemic lupus erythematosus	182.82	10.54	10	97241	254328	110237720
Eye haemorrhage	181.98	10.54	119	97132	11655	110480393
Motor dysfunction	180.97	10.54	159	97092	24247	110467801
Sneezing	180.52	10.54	179	97072	31805	110460243
Sinus congestion	180.36	10.54	175	97076	30284	110461764
Cataract	177.31	10.54	279	96972	79206	110412842
Coordination abnormal	176.43	10.54	159	97092	25069	110466979
Eating disorder	174.72	10.54	173	97078	30685	110461363
Glossodynia	172.09	10.54	5	97246	221999	110270049
Multi-organ disorder	170.09	10.54	75	97176	3306	110488742
Wrong product administered	167.51	10.54	110	97141	10850	110481198
Off label use	164.50	10.54	721	96530	1499464	108992584
Sinus disorder	164.39	10.54	172	97079	32556	110459492
Anti-insulin antibody positive	162.34	10.54	40	97211	251	110491797
Respiratory tract congestion	161.89	10.54	166	97085	30691	110461357
Drug intolerance	159.62	10.54	79	97172	406433	110085615
Hypoglycaemic unconsciousness	154.79	10.54	53	97198	1167	110490881
Cardiac failure congestive	152.64	10.54	380	96871	150620	110341428
Cerebrovascular accident	149.56	10.54	423	96828	180861	110311187
Pericarditis	144.80	10.54	13	97238	219101	110272947
Synovitis	142.64	10.54	33	97218	274059	110217989
Hemiparesis	138.91	10.54	182	97069	43721	110448327
Helicobacter infection	137.74	10.54	5	97246	181872	110310176
Treatment failure	135.38	10.54	38	97213	277196	110214852
Toxicity to various agents	135.12	10.54	134	97117	480421	110011627
Joint swelling	134.55	10.54	115	97136	442730	110049318
Infusion related reaction	128.48	10.54	89	97162	381073	110110975
Accidental underdose	124.94	10.54	46	97205	1259	110490789
Muscle spasticity	124.83	10.54	156	97095	35759	110456289
Hypoglycaemic seizure	122.44	10.54	42	97209	930	110491118
Folliculitis	122.33	10.54	6	97245	167647	110324401
Product storage error	121.49	10.54	121	97130	21607	110470441
Aphasia	119.17	10.54	198	97053	58799	110433249
Lower respiratory tract infection	117.44	10.54	34	97217	243072	110248976
Insulin resistance	115.66	10.54	47	97204	1687	110490361
Alopecia	115.39	10.54	91	97160	364662	110127386
Therapeutic product effect decreased	114.70	10.54	36	97215	244280	110247768
Arthropathy	114.15	10.54	55	97196	287467	110204581
Incorrect dose administered	113.44	10.54	269	96982	103372	110388676
Muscle injury	109.74	10.54	3	97248	140804	110351244
Irritable bowel syndrome	107.80	10.54	10	97241	164205	110327843
Infective pulmonary exacerbation of cystic fibrosis	107.05	10.54	95	97156	14676	110477372
Abdominal discomfort	104.84	10.54	115	97136	393743	110098305
Diabetic retinopathy	102.87	10.54	54	97197	3510	110488538
Cystitis	99.38	10.54	195	97056	65841	110426207
Rash	98.03	10.54	381	96870	820583	109671465
Product complaint	97.57	10.54	88	97163	13884	110478164
Rhinorrhoea	94.02	10.54	249	97002	102417	110389631
Hepatic enzyme increased	93.02	10.54	87	97164	320805	110171243
Arthralgia	92.95	10.54	362	96889	779270	109712778
Dysarthria	90.61	10.54	217	97034	83904	110408144
Stomatitis	88.54	10.54	65	97186	270177	110221871
Anti-insulin antibody increased	85.50	10.54	20	97231	97	110491951
Thyroid disorder	84.89	10.54	89	97162	16880	110475168
Musculoskeletal stiffness	84.52	10.54	73	97178	279749	110212299
Ill-defined disorder	81.34	10.54	19	97232	156834	110335214
Nasal obstruction	80.64	10.54	45	97206	3305	110488743
Drug ineffective	79.84	10.54	905	96346	1519635	108972413
Fall	78.79	10.54	844	96407	602638	109889410
Hyperkalaemia	76.46	10.54	278	96973	135518	110356530
Psoriatic arthropathy	76.02	10.54	39	97212	196722	110295326
Swelling	75.50	10.54	120	97131	350921	110141127
Fibromyalgia	75.32	10.54	28	97223	170881	110321167
C-reactive protein abnormal	75.09	10.54	12	97239	129683	110362365
Skin exfoliation	74.66	10.54	207	97044	87444	110404604
Mobility decreased	74.08	10.54	60	97191	237362	110254686
Hypoglycaemia unawareness	73.68	10.54	21	97230	245	110491803
Bursitis	73.05	10.54	13	97238	129905	110362143
Loss of consciousness	73.02	10.54	354	96897	195952	110296096
Malnutrition	72.57	10.54	104	97147	27175	110464873
Lip dry	71.68	10.54	4	97247	100079	110391969
Throat clearing	67.46	10.54	44	97207	4289	110487759
Increased insulin requirement	67.43	10.54	19	97232	212	110491836
Blister	66.63	10.54	61	97190	227315	110264733
Blood cholesterol increased	66.50	10.54	40	97211	184745	110307303
Palpitations	64.99	10.54	295	96956	158917	110333131
Arthritis	64.34	10.54	305	96946	167281	110324767
Blood pressure increased	63.60	10.54	417	96834	257956	110234092
Hypersensitivity	63.15	10.54	166	97085	403832	110088216
Intentional product use issue	63.08	10.54	75	97176	247831	110244217
Cutaneous amyloidosis	63.07	10.54	14	97237	51	110491997
Product use in unapproved indication	62.46	10.54	194	97057	447183	110044865
Anti-insulin antibody	61.26	10.54	14	97237	60	110491988
Contraindicated product administered	61.18	10.54	77	97174	248190	110243858
Diabetic neuropathy	60.90	10.54	50	97201	6949	110485099
Joint range of motion decreased	60.76	10.54	16	97235	121816	110370232
Influenza like illness	60.30	10.54	193	97058	88219	110403829
Diabetic metabolic decompensation	59.35	10.54	39	97212	3850	110488198
Dehydration	58.72	10.54	434	96817	279077	110212971
Influenza	58.67	10.54	299	96952	168802	110323246
Acute respiratory failure	58.51	10.54	172	97079	75088	110416960
Insulin C-peptide decreased	57.07	10.54	14	97237	86	110491962
Blood insulin increased	56.87	10.54	19	97232	387	110491661
Sopor	56.29	10.54	109	97142	36437	110455611
Myelosuppression	56.28	10.54	8	97243	94332	110397716
Product administration error	56.11	10.54	110	97141	37107	110454941
Type 1 diabetes mellitus	55.48	10.54	53	97198	8994	110483054
Chest discomfort	54.56	10.54	299	96952	173549	110318499
Dysphagia	53.57	10.54	272	96979	153328	110338720
Expired product administered	53.42	10.54	50	97201	8270	110483778
Pancreatic carcinoma	52.32	10.54	65	97186	14807	110477241
Dry mouth	51.39	10.54	60	97191	199888	110292160
Red blood cell sedimentation rate increased	50.77	10.54	5	97246	78297	110413751
Diabetic foot	50.49	10.54	36	97215	4059	110487989
Sleep disorder	49.57	10.54	61	97190	198583	110293465
Wound	49.57	10.54	81	97170	234356	110257692
Completed suicide	49.17	10.54	86	97165	242295	110249753
Inflammation	48.58	10.54	59	97192	193179	110298869
Discomfort	48.44	10.54	71	97180	214636	110277412
Pulmonary oedema	46.80	10.54	194	97057	100465	110391583
Migraine	45.76	10.54	50	97201	171602	110320446
Impaired healing	45.41	10.54	64	97187	196653	110295395
Shock hypoglycaemic	44.65	10.54	14	97237	231	110491817
C-reactive protein increased	43.59	10.54	78	97173	217841	110274207
Hypoaesthesia	43.31	10.54	137	97114	314086	110177962
Liver injury	42.13	10.54	42	97209	150371	110341677
Peripheral venous disease	42.03	10.54	11	97240	84106	110407942
Type 2 diabetes mellitus	41.57	10.54	57	97194	177175	110314873
Drug hypersensitivity	41.48	10.54	232	97019	453858	110038190
Device operational issue	41.00	10.54	20	97231	1112	110490936
Grip strength decreased	40.99	10.54	10	97241	80164	110411884
Drug abuse	38.73	10.54	60	97191	177351	110314697
Insomnia	38.18	10.54	175	97076	360415	110131633
Ketosis	38.01	10.54	22	97229	1732	110490316
Systemic infection	37.93	10.54	45	97206	9774	110482274
Diabetic coma	37.42	10.54	20	97231	1348	110490700
Pre-eclampsia	37.38	10.54	42	97209	8608	110483440
Renal failure	37.37	10.54	333	96918	226241	110265807
No adverse event	37.26	10.54	146	97105	73693	110418355
Infection	37.04	10.54	178	97073	362022	110130026
Peritonitis bacterial	36.99	10.54	46	97205	10487	110481561
Sciatica	36.15	10.54	18	97233	92381	110399667
Autoimmune disorder	35.85	10.54	7	97244	65476	110426572
Asthenia	35.18	10.54	823	96428	688176	109803872
Hip arthroplasty	35.06	10.54	4	97247	55809	110436239
Product dose omission issue	34.71	10.54	434	96817	321348	110170700
Diabetic nephropathy	34.66	10.54	27	97224	3481	110488567
Hypervolaemia	34.66	10.54	109	97142	49351	110442697
Syncope	34.60	10.54	300	96951	202236	110289812
Cellulitis	34.47	10.54	209	97042	125807	110366241
Paraesthesia	34.40	10.54	126	97125	276395	110215653
Toe amputation	33.64	10.54	29	97222	4309	110487739
Euglycaemic diabetic ketoacidosis	33.42	10.54	46	97205	11577	110480471
Wound infection	33.16	10.54	22	97229	96443	110395605
Oedema peripheral	32.81	10.54	437	96814	328223	110163825
Scleroedema	32.36	10.54	10	97241	157	110491891
Pericardial effusion	32.07	10.54	117	97134	57100	110434948
Gait inability	31.84	10.54	44	97207	136332	110355716
Disease progression	31.82	10.54	109	97142	243925	110248123
Injury	31.51	10.54	68	97183	177197	110314851
Cystic fibrosis	31.47	10.54	29	97222	4702	110487346
Psoriasis	31.46	10.54	221	97030	139772	110352276
Adverse drug reaction	31.29	10.54	28	97223	105531	110386517
Live birth	31.26	10.54	11	97240	69473	110422575
Vomiting	31.08	10.54	1033	96218	909642	109582406
Anaemia	30.90	10.54	663	96588	546423	109945625
Osteoarthritis	30.88	10.54	72	97179	182551	110309497
Hypercholesterolaemia	30.84	10.54	21	97230	90816	110401232
Chronic kidney disease	30.84	10.54	141	97110	76150	110415898
Hyperinsulinaemic hypoglycaemia	30.59	10.54	11	97240	281	110491767
Diabetes mellitus	30.54	10.54	170	97081	99211	110392837
Endometrial disorder	30.51	10.54	14	97237	678	110491370
Insulinoma	30.39	10.54	10	97241	194	110491854
Diabetic foot infection	30.18	10.54	15	97236	869	110491179
Sepsis	30.12	10.54	429	96822	326917	110165131
Prescribed overdose	30.07	10.54	20	97231	87561	110404487
Nail disorder	30.06	10.54	7	97244	57928	110434120
Insulin autoimmune syndrome	29.58	10.54	14	97237	728	110491320
Night sweats	29.54	10.54	45	97206	133938	110358110
Onychomadesis	29.38	10.54	3	97248	45660	110446388
Product dispensing error	29.25	10.54	52	97199	16293	110475755
Product use issue	28.58	10.54	159	97092	311536	110180512
Renal impairment	28.56	10.54	272	96979	188173	110303875
Secretion discharge	28.32	10.54	58	97193	20186	110471862
Left atrial dilatation	28.02	10.54	24	97227	3536	110488512
Impaired gastric emptying	27.40	10.54	45	97206	13230	110478818
Atrial fibrillation	27.05	10.54	315	96936	229327	110262721
Drug resistance	26.99	10.54	8	97243	56366	110435682
Epilepsy	26.91	10.54	29	97222	100180	110391868
Clostridium test positive	26.76	10.54	40	97211	10853	110481195
Renal disorder	26.74	10.54	100	97151	49379	110442669
Localised infection	26.68	10.54	91	97160	42957	110449091
Contusion	26.67	10.54	110	97141	233251	110258797
Neck pain	26.53	10.54	42	97209	123088	110368960
Knee arthroplasty	26.40	10.54	12	97239	64936	110427112
Diabetic retinal oedema	26.11	10.54	11	97240	433	110491615
Treatment noncompliance	25.96	10.54	130	97121	72860	110419188
Retinopathy	25.38	10.54	25	97226	4404	110487644
Obesity	25.05	10.54	38	97213	113313	110378735
Transcription medication error	24.98	10.54	12	97239	645	110491403
Rhonchi	24.96	10.54	25	97226	4493	110487555
Vitreous haemorrhage	24.49	10.54	25	97226	4595	110487453
Diaphragmatic disorder	24.22	10.54	17	97234	1869	110490179
Keratitis	24.00	10.54	26	97225	5118	110486930
Infusion site induration	23.97	10.54	15	97236	1361	110490687
Lung disorder	23.75	10.54	80	97171	179967	110312081
Blindness	23.55	10.54	78	97173	36281	110455767
Peripheral swelling	23.23	10.54	235	97016	403799	110088249
Dyspnoea exertional	23.22	10.54	164	97087	103896	110388152
Drug ineffective for unapproved indication	23.19	10.54	34	97217	102804	110389244
Loss of personal independence in daily activities	23.14	10.54	62	97189	149958	110342090
Haematocrit increased	23.02	10.54	25	97226	4934	110487114
Blood ketone body	22.95	10.54	8	97243	186	110491862
Myocardial infarction	22.85	10.54	264	96987	191819	110300229
Medical device site abscess	22.33	10.54	8	97243	202	110491846
Glomerular filtration rate decreased	22.33	10.54	66	97185	28890	110463158
Frequent bowel movements	22.30	10.54	18	97233	71372	110420676
Obstructive airways disorder	22.28	10.54	90	97161	46059	110445989
Therapy non-responder	22.07	10.54	68	97183	157239	110334809
Hypoaldosteronism	21.80	10.54	11	97240	658	110491390
Haemoglobin increased	21.63	10.54	33	97218	9114	110482934
Medical device site cellulitis	21.59	10.54	8	97243	223	110491825
Product name confusion	21.56	10.54	8	97243	224	110491824
Bone erosion	21.45	10.54	7	97244	46364	110445684
Hepatic encephalopathy	21.41	10.54	64	97187	28192	110463856
Hypovolaemia	21.30	10.54	54	97197	21620	110470428
Ischaemic stroke	21.15	10.54	82	97169	41181	110450867
Pruritus	21.11	10.54	372	96879	581188	109910860
Urticaria	21.11	10.54	179	97072	318678	110173370
Febrile neutropenia	20.90	10.54	178	97073	316589	110175459
Hyperhidrosis	20.77	10.54	254	96997	187044	110305004
Cough	20.70	10.54	542	96709	461099	110030949
Pseudomonal bacteraemia	20.23	10.54	22	97229	4349	110487699
Urinary tract infection	20.22	10.54	401	96850	325881	110166167
Malignant neoplasm progression	20.12	10.54	82	97169	174485	110317563
Postprandial hypoglycaemia	20.08	10.54	7	97244	163	110491885
Delirium	19.93	10.54	57	97194	134968	110357080
Pertussis	19.81	10.54	13	97238	1280	110490768
Joint stiffness	19.73	10.54	18	97233	67225	110424823
Dermatitis bullous	19.71	10.54	46	97205	17483	110474565
Diabetic hyperglycaemic coma	19.61	10.54	6	97245	91	110491957
Exostosis	19.46	10.54	8	97243	45948	110446100
Finger deformity	19.29	10.54	3	97248	33089	110458959
Intraventricular haemorrhage	19.26	10.54	24	97227	5483	110486565
Oedematous pancreatitis	19.16	10.54	14	97237	1640	110490408
Blood creatinine increased	18.99	10.54	245	97006	182644	110309404
Neuropathy peripheral	18.97	10.54	241	97010	179036	110313012
Mucosal dryness	18.94	10.54	21	97230	4242	110487806
Foot amputation	18.91	10.54	12	97239	1116	110490932
Muscular weakness	18.77	10.54	315	96936	248153	110243895
Intensive care unit acquired weakness	18.76	10.54	16	97235	2343	110489705
Epileptic encephalopathy	18.70	10.54	10	97241	675	110491373
Mucosal inflammation	18.69	10.54	35	97216	96106	110395942
Glycogen storage disease type VIII	18.37	10.54	4	97247	13	110492035
Patella fracture	18.37	10.54	16	97235	2410	110489638
Nausea	18.33	10.54	1291	95960	1234399	109257649
Musculoskeletal pain	18.08	10.54	91	97160	182932	110309116
Epididymitis	18.05	10.54	16	97235	2468	110489580
Presyncope	18.04	10.54	88	97163	48799	110443249
Pseudolymphoma	17.92	10.54	12	97239	1223	110490825
Cold sweat	17.74	10.54	51	97200	21980	110470068
Acetonaemia	17.57	10.54	9	97242	556	110491492
Neuropathic arthropathy	17.54	10.54	9	97242	558	110491490
Onychomycosis	17.50	10.54	6	97245	38525	110453523
Amylase decreased	17.47	10.54	7	97244	242	110491806
Neutropenic sepsis	17.45	10.54	3	97248	30743	110461305
Diabetic gastroparesis	17.33	10.54	8	97243	393	110491655
Coronary artery disease	17.19	10.54	115	97136	71575	110420473
Croup infectious	17.18	10.54	11	97240	1039	110491009
Neutrophil count decreased	17.16	10.54	52	97199	120889	110371159
Pneumonia	17.06	10.54	938	96313	875776	109616272
Electrolyte imbalance	16.92	10.54	71	97180	36957	110455091
Lower limb fracture	16.90	10.54	25	97226	75323	110416725
Gastrointestinal haemorrhage	16.88	10.54	221	97030	165297	110326751
Sedation	16.75	10.54	22	97229	69661	110422387
Product monitoring error	16.75	10.54	29	97222	8898	110483150
Balanoposthitis	16.74	10.54	12	97239	1364	110490684
Muscle spasms	16.73	10.54	160	97091	277997	110214051
Diabetic wound	16.58	10.54	5	97246	72	110491976
Product prescribing error	16.57	10.54	89	97162	51242	110440806
Immunosuppressant drug level decreased	16.55	10.54	16	97235	2755	110489293
Adverse reaction	16.55	10.54	3	97248	29591	110462457
Depression	16.45	10.54	189	97062	317146	110174902
Acute myocardial infarction	16.40	10.54	128	97123	83649	110408399
Diabetic complication	16.39	10.54	12	97239	1410	110490638
Cognitive disorder	16.02	10.54	33	97218	87478	110404570
Enterococcus test positive	15.92	10.54	16	97235	2888	110489160
Poor quality product administered	15.87	10.54	20	97231	4621	110487427
Pancreatitis acute	15.87	10.54	99	97152	60175	110431873
Hypoxia	15.85	10.54	179	97072	129336	110362712
Polydipsia	15.78	10.54	26	97225	7662	110484386
Psychotic disorder	15.72	10.54	13	97238	50924	110441124
Hypoglycaemic encephalopathy	15.60	10.54	9	97242	704	110491344
Congestive hepatopathy	15.52	10.54	21	97230	5199	110486849
Insulin C-peptide increased	15.47	10.54	6	97245	190	110491858
Microalbuminuria	15.44	10.54	11	97240	1238	110490810
Dawn phenomenon	15.17	10.54	3	97248	5	110492043
Pseudohyponatraemia	15.13	10.54	6	97245	202	110491846
Pulmonary fibrosis	15.11	10.54	43	97208	101999	110390049
Dyspepsia	15.10	10.54	102	97149	190863	110301185
Serotonin syndrome	14.92	10.54	18	97233	59135	110432913
Generalised oedema	14.92	10.54	60	97191	30644	110461404
Head injury	14.86	10.54	76	97175	42941	110449107
Non-cardiogenic pulmonary oedema	14.85	10.54	13	97238	1971	110490077
Blindness transient	14.81	10.54	22	97229	5934	110486114
Chronic obstructive pulmonary disease	14.80	10.54	154	97097	109004	110383044
Full blood count abnormal	14.71	10.54	92	97159	55960	110436088
Infusion site pain	14.69	10.54	41	97210	17378	110474670
Basal cell carcinoma	14.67	10.54	11	97240	45259	110446789
Condition aggravated	14.64	10.54	514	96737	734322	109757726
Intercepted product dispensing error	14.64	10.54	6	97245	220	110491828
Chest pain	14.64	10.54	434	96817	375941	110116107
White blood cell count decreased	14.63	10.54	130	97121	229260	110262788
Cardiac disorder	14.63	10.54	116	97135	76164	110415884
Eye discharge	14.58	10.54	27	97224	8727	110483321
Heart rate decreased	14.49	10.54	32	97219	82724	110409324
Colitis ulcerative	14.31	10.54	29	97222	77334	110414714
Post streptococcal glomerulonephritis	14.28	10.54	5	97246	118	110491930
Varices oesophageal	14.28	10.54	24	97227	7191	110484857
Vascular parkinsonism	14.24	10.54	5	97246	119	110491929
Somogyi phenomenon	14.22	10.54	3	97248	8	110492040
Arteriosclerosis	14.18	10.54	51	97200	24716	110467332
Urinary tract obstruction	14.16	10.54	20	97231	5157	110486891
Leg amputation	14.14	10.54	18	97233	4200	110487848
Laryngitis	14.14	10.54	10	97241	42401	110449647
Hypotension	14.11	10.54	579	96672	523270	109968778
Glycosylated haemoglobin decreased	13.93	10.54	9	97242	863	110491185
Tendonitis	13.84	10.54	3	97248	26080	110465968
Electrocardiogram abnormal	13.82	10.54	42	97209	18667	110473381
Blood ketone body increased	13.78	10.54	9	97242	879	110491169
Neutropenia	13.78	10.54	239	97012	374381	110117667
Dystonia	13.62	10.54	3	97248	25802	110466246
Injury associated with device	13.58	10.54	18	97233	4371	110487677
Lactic acidosis	13.58	10.54	133	97118	92678	110399370
Back injury	13.54	10.54	13	97238	47386	110444662
Medication error	13.52	10.54	147	97104	105219	110386829
Peripheral arterial occlusive disease	13.47	10.54	27	97224	9253	110482795
Adenocarcinoma pancreas	13.39	10.54	13	97238	2250	110489798
Adverse event	13.24	10.54	50	97201	108759	110383289
Weight decreased	13.22	10.54	520	96731	467537	110024511
Blood ketone body present	13.18	10.54	5	97246	149	110491899
Bone marrow failure	13.16	10.54	19	97232	57829	110434219
Myocarditis	13.11	10.54	5	97246	30050	110461998
Osteomyelitis	12.88	10.54	65	97186	36535	110455513
Pancreatic cyst	12.84	10.54	14	97237	2776	110489272
Fasting	12.82	10.54	4	97247	65	110491983
Pyelonephritis	12.80	10.54	50	97201	25200	110466848
Renal transplant	12.77	10.54	15	97236	3223	110488825
Renal tubular disorder	12.48	10.54	23	97228	7406	110484642
Exposure via eye contact	12.44	10.54	3	97248	17	110492031
Bradycardia	12.42	10.54	199	97052	155318	110336730
Urine ketone body present	12.25	10.54	16	97235	3830	110488218
Device expulsion	12.11	10.54	6	97245	30885	110461163
Therapy partial responder	12.01	10.54	9	97242	37052	110454996
Maternal exposure during pregnancy	11.99	10.54	155	97096	254728	110237320
Hypoxic-ischaemic encephalopathy	11.97	10.54	25	97226	8822	110483226
Visual acuity reduced	11.93	10.54	58	97193	32115	110459933
Arrhythmia	11.84	10.54	103	97148	69472	110422576
Skin ulcer	11.77	10.54	96	97155	63549	110428499
Mouth ulceration	11.77	10.54	15	97236	48123	110443925
Intercepted product selection error	11.77	10.54	3	97248	22	110492026
Listeraemia	11.77	10.54	4	97247	86	110491962
Device failure	11.72	10.54	22	97229	7185	110484863
Therapeutic product effect incomplete	11.71	10.54	133	97118	223672	110268376
Gestational hypertension	11.68	10.54	12	97239	2222	110489826
Respiratory depression	11.40	10.54	7	97244	31994	110460054
Neuroleptic malignant syndrome	11.39	10.54	8	97243	34051	110457997
Cytomegalovirus infection	11.32	10.54	19	97232	54425	110437623
Pancreatic carcinoma metastatic	11.26	10.54	16	97235	4148	110487900
Drug reaction with eosinophilia and systemic symptoms	11.15	10.54	36	97215	82059	110409989
Hypercreatinaemia	11.10	10.54	6	97245	414	110491634
Erythema	11.02	10.54	185	97066	291262	110200786
General physical health deterioration	10.98	10.54	468	96783	424827	110067221
Tinnitus	10.94	10.54	23	97228	60517	110431531
Amputation	10.92	10.54	8	97243	941	110491107
Necrotising fasciitis	10.91	10.54	22	97229	7569	110484479
Pulmonary congestion	10.90	10.54	55	97196	30911	110461137
Poisoning	10.89	10.54	6	97245	29099	110462949
Drug dependence	10.83	10.54	17	97234	50003	110442045
Hypertension	10.80	10.54	354	96897	509730	109982318
Prescribed underdose	10.77	10.54	26	97225	65148	110426900
Ear pain	10.68	10.54	19	97232	53207	110438841
Dyspnoea	10.64	10.54	1120	96131	1105752	109386296
Colitis	10.61	10.54	50	97201	102273	110389775
Anaemia of malignant disease	10.57	10.54	8	97243	988	110491060

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A10AB04	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, fast-acting
ATC	A10AC04	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, intermediate-acting
ATC	A10AD04	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
FDA CS	M0011417	Insulin
FDA Chemical/Ingredient	N0000004931	Insulin
FDA EPC	N0000175453	Insulin Analog
FDA EPC	N0000175944	Insulin
MeSH PA	D007004	Hypoglycemic Agents
CHEBI has role	CHEBI:35526	hypoglycemic agent
CHEBI has role	CHEBI:22587	antiviral agent
CHEBI has role	CHEBI:35469	antidepressant
CHEBI has role	CHEBI:35476	antipsychotic agent
CHEBI has role	CHEBI:35480	analgesic
CHEBI has role	CHEBI:35554	cardiovascular drug
CHEBI has role	CHEBI:35674	antihypertensive agent
CHEBI has role	CHEBI:35705	immunosuppressive agent
CHEBI has role	CHEBI:35821	anticholesteremic drug
CHEBI has role	CHEBI:39456	antiglaucoma drug
CHEBI has role	CHEBI:48407	antiparkinson drug
CHEBI has role	CHEBI:50864	insulin-sensitizing drug
CHEBI has role	CHEBI:66981	ophthalmology drug
CHEBI has role	CHEBI:73336	vulnerary
CHEBI has role	CHEBI:74518	anti-obesity agent
CHEBI has role	CHEBI:76916	hyperglycemic agent
CHEBI has role	CHEBI:145947	antiatherosclerotic agent
CHEBI has role	CHEBI:231911	renoprotective agent

Related Drugs by ATC class:

A10AB Insulins and analogues for injection, fast-acting 5 drugs

insulin aspartinsulin beefinsulin glulisineinsulin humaninsulin pork

A10AC Insulins and analogues for injection, intermediate-acting 3 drugs

insulin beefinsulin humaninsulin pork

A10AD Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting 5 drugs

insulin aspartinsulin beefinsulin degludecinsulin humaninsulin pork

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Diabetes mellitus type 2	indication	44054006	DOID:9352
Diabetes mellitus type 1	indication	46635009	DOID:9744

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Insulin receptor	Kinase	P06213	INSR_HUMAN	AGONIST				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D04477	KEGG_DRUG
4020998	VUID
N0000179468	NUI
4017559	VANDF
4017569	VANDF
4019786	VANDF
4020998	VANDF
4021213	VANDF
CHEBI:232799	CHEBI
CHEMBL1201538	ChEMBL_ID
CHEMBL1201611	ChEMBL_ID
DB00046	DRUGBANK_ID
135805	RXNORM
283144	MMSL
335485	MMSL
4882	MMSL
4885	MMSL
4886	MMSL
6127	MMSL
8603	MMSL
d00262	MMSL
d04369	MMSL
d04373	MMSL
d04511	MMSL
000869	NDDF
000870	NDDF
006061	NDDF
006518	NDDF
007750	NDDF
126210001	SNOMEDCT_US
388454007	SNOMEDCT_US
412210000	SNOMEDCT_US
417423002	SNOMEDCT_US
420609005	SNOMEDCT_US
426313003	SNOMEDCT_US
96367001	SNOMEDCT_US
C0293359	UMLSCUI
D061268	MESH_DESCRIPTOR_UI
C0795635	UMLSCUI
DB00030	DRUGBANK_ID
7278	INN_ID
16132438	PUBCHEM_CID
118984375	PUBCHEM_CID
GFX7QIS1II	UNII
5186	INN_ID
CHEBI:5931	CHEBI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Humalog	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7510	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	34 sections
Humalog Mix75/25	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7511	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	29 sections
Humalog Mix50/50	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7512	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	29 sections
Humalog	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7516	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	34 sections
Humalog	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7533	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	34 sections
HumalogKwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7712	INJECTION, SOLUTION	200 [iU]	SUBCUTANEOUS	BLA	34 sections
Humalog Junior KwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7714	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	34 sections
LYUMJEV	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7726	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	33 sections
LYUMJEV	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7728	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	33 sections
Insulin Lispro	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7737	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	33 sections
Insulin Lispro Junior KwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7752	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	33 sections
LYUMJEV KwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-8207	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	33 sections
HumalogTempo Pen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-8208	INJECTION, SOLUTION	200 [iU]	SUBCUTANEOUS	BLA	34 sections
Humalog Tempo Pen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-8213	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	34 sections
Insulin Lispro KwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-8222	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	33 sections
LYUMJEV KwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-8228	INJECTION, SOLUTION	200 [iU]	SUBCUTANEOUS	BLA	33 sections
Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 KwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-8233	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	29 sections
LYUMJEVTempo Pen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-8235	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	33 sections
LYUMJEVJunior KwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-8351	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	33 sections
Humalog Mix75/25 KwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-8797	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	29 sections
Humalog Mix50/50 KwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-8798	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	29 sections
HumalogKwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-8799	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	34 sections
ADMELOG	HUMAN PRESCRIPTION DRUG LABEL	1	0024-5924	INJECTION, SOLUTION	100 U	SUBCUTANEOUS	BLA	33 sections
ADMELOG	HUMAN PRESCRIPTION DRUG LABEL	1	0024-5925	INJECTION, SOLUTION	100 U	SUBCUTANEOUS	BLA	33 sections
ADMELOG	HUMAN PRESCRIPTION DRUG LABEL	1	0024-5926	INJECTION, SOLUTION	100 U	SUBCUTANEOUS	BLA	33 sections
HUMALOG	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1375	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	32 sections
HumalogKwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1663	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	32 sections
HumalogKwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4073	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	32 sections
HUMALOG	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4488	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	32 sections
Insulin Lispro	HUMAN PRESCRIPTION DRUG LABEL	1	50090-5391	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	32 sections