Target Card Uniprot Example: P23975

insulin aspart 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4981	116094-23-6

Description:

Molecule	Description
Synonyms: insulin aspart protamine recombinant insulin aspart protamine insulin aspart protamine crystalline insulin aspart insulin aspart recombinant novolog insulin aspart [rDNA origin] novorapid	Insulin that has been modified to contain an ASPARTIC ACID instead of a PROLINE at position 38 of the B-chain. Molecular weight: 5825.60 Formula: C256H381N65O79S6 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 2345.16 ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
40	U	P
40	U	P
40	U	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Sept. 20, 2019	PMDA	Novo Nordisk Pharma Ltd.
Sept. 7, 1999	EMA	NovoRapid
June 7, 2000	FDA	NOVO NORDISK INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Diabetic ketoacidosis	1392.54	10.81	550	46663	17322	50540589
Hypoglycaemia	1212.60	10.81	704	46509	52877	50505034
Blood glucose increased	1179.81	10.81	767	46446	70557	50487354
Blood glucose decreased	402.46	10.81	236	46977	17975	50539936
Hyperglycaemia	370.89	10.81	292	46921	36113	50521798
Diabetes mellitus inadequate control	318.79	10.81	181	47032	12964	50544947
Ketoacidosis	209.01	10.81	92	47121	3803	50554108
Glycosylated haemoglobin increased	199.54	10.81	124	47089	10482	50547429
Diabetic retinopathy	182.39	10.81	71	47142	2139	50555772
Hypoglycaemic unconsciousness	161.76	10.81	49	47164	673	50557238
Blood glucose fluctuation	160.23	10.81	78	47135	4068	50553843
Acute kidney injury	158.46	10.81	520	46693	227538	50330373
Hypoglycaemic coma	158.00	10.81	65	47148	2268	50555643
Product leakage	153.84	10.81	44	47169	488	50557423
Drug ineffective	138.16	10.81	356	46857	818977	49738934
Diabetic metabolic decompensation	123.73	10.81	48	47165	1432	50556479
Blood glucose abnormal	103.25	10.81	69	47144	6603	50551308
Drug intolerance	102.77	10.81	38	47175	219066	50338845
Arthropathy	93.79	10.81	17	47196	157889	50400022
Synovitis	89.06	10.81	7	47206	123858	50434053
Systemic lupus erythematosus	88.29	10.81	13	47200	140609	50417302
Contraindicated product administered	84.34	10.81	18	47195	148940	50408971
Diabetic neuropathy	83.16	10.81	48	47165	3543	50554368
Product quality issue	83.05	10.81	122	47091	30736	50527175
Joint swelling	82.32	10.81	65	47148	245221	50312690
Treatment failure	81.34	10.81	15	47198	137622	50420289
Alopecia	77.23	10.81	69	47144	244978	50312933
Infusion related reaction	75.22	10.81	32	47181	169525	50388386
Glossodynia	74.15	10.81	10	47203	115559	50442352
Hypoglycaemic seizure	72.76	10.81	24	47189	441	50557470
Exposure during pregnancy	72.54	10.81	263	46950	120752	50437159
Hyper IgE syndrome	70.32	10.81	23	47190	411	50557500
Liquid product physical issue	67.61	10.81	26	47187	757	50557154
Hypoglycaemia unawareness	64.89	10.81	16	47197	94	50557817
Pain	63.73	10.81	301	46912	578602	49979309
Arthralgia	63.00	10.81	205	47008	438497	50119414
Diabetic ketosis	60.49	10.81	17	47196	176	50557735
Rheumatoid arthritis	58.05	10.81	62	47151	202488	50355423
Anti-insulin antibody positive	57.41	10.81	14	47199	78	50557833
Pericarditis	55.03	10.81	5	47208	78684	50479227
Ketosis	54.76	10.81	20	47193	503	50557408
Completed suicide	53.69	10.81	28	47185	131861	50426050
Hypoglycaemia neonatal	50.50	10.81	22	47191	886	50557025
Therapeutic product effect decreased	49.57	10.81	33	47180	136017	50421894
Toxicity to various agents	49.54	10.81	76	47137	212423	50345488
Infective pulmonary exacerbation of cystic fibrosis	49.28	10.81	48	47165	7861	50550050
Abdominal discomfort	49.22	10.81	88	47125	231553	50326358
Hyperkalaemia	49.04	10.81	126	47087	47963	50509948
Wound	48.46	10.81	19	47194	105775	50452136
Restrictive pulmonary disease	46.79	10.81	24	47189	1400	50556511
Drug hypersensitivity	45.95	10.81	104	47109	250906	50307005
Lactic acidosis	45.59	10.81	98	47115	33257	50524654
Discomfort	44.12	10.81	23	47190	108357	50449554
Lipodystrophy acquired	42.52	10.81	22	47191	1307	50556604
Chronic kidney disease	42.42	10.81	106	47107	39665	50518246
Wrong product administered	42.06	10.81	37	47176	5323	50552588
Premature baby	41.60	10.81	67	47146	18270	50539641
Euglycaemic diabetic ketoacidosis	40.86	10.81	28	47185	2791	50555120
Heart sounds	40.79	10.81	17	47196	613	50557298
Diabetes mellitus	40.57	10.81	119	47094	48914	50508997
Foetal exposure during pregnancy	40.43	10.81	83	47130	27276	50530635
Musculoskeletal stiffness	39.45	10.81	37	47176	128444	50429467
Renal failure	39.25	10.81	200	47013	106433	50451478
Prolonged expiration	38.58	10.81	17	47196	704	50557207
Ketonuria	38.37	10.81	15	47198	457	50557454
Myocardial infarction	37.82	10.81	174	47039	88853	50469058
Oesophageal spasm	36.14	10.81	24	47189	2272	50555639
Polycystic ovaries	34.42	10.81	24	47189	2460	50555451
Dehydration	33.93	10.81	251	46962	152198	50405713
Sleep apnoea syndrome	33.62	10.81	71	47142	23797	50534114
Polyuria	33.19	10.81	37	47176	7084	50550827
Helicobacter infection	32.59	10.81	4	47209	49698	50508213
Sinusitis	32.56	10.81	69	47144	170489	50387422
Insulin resistance	32.50	10.81	15	47198	693	50557218
Bladder agenesis	32.45	10.81	10	47203	146	50557765
Cloacal exstrophy	32.01	10.81	10	47203	153	50557758
Genitalia external ambiguous	32.01	10.81	10	47203	153	50557758
Oesophageal pain	31.83	10.81	24	47189	2778	50555133
Congenital ectopic bladder	31.61	10.81	9	47204	98	50557813
Swelling	31.50	10.81	90	47123	200782	50357129
Caudal regression syndrome	31.37	10.81	10	47203	164	50557747
Lethargy	30.92	10.81	109	47104	49323	50508588
Gastrointestinal malformation	30.77	10.81	10	47203	175	50557736
Meconium stain	30.25	10.81	10	47203	185	50557726
Anencephaly	29.34	10.81	10	47203	204	50557707
Gastrointestinal disorder congenital	29.23	10.81	9	47204	131	50557780
Congenital genital malformation	28.56	10.81	9	47204	142	50557769
Tethered cord syndrome	28.42	10.81	10	47203	225	50557686
Product physical issue	28.33	10.81	27	47186	4305	50553606
Pre-eclampsia	27.96	10.81	36	47177	8008	50549903
Hypersensitivity	27.79	10.81	105	47108	215056	50342855
Coronavirus test positive	27.73	10.81	13	47200	623	50557288
Blood ketone body	27.59	10.81	7	47206	47	50557864
Pancreatitis	27.54	10.81	95	47118	42519	50515392
Neural tube defect	26.43	10.81	9	47204	183	50557728
Respiration abnormal	26.38	10.81	28	47185	5074	50552837
Diabetic nephropathy	26.05	10.81	16	47197	1323	50556588
Sepsis neonatal	25.83	10.81	11	47202	419	50557492
Irritable bowel syndrome	25.68	10.81	8	47205	51433	50506478
Diabetic gastroparesis	25.56	10.81	9	47204	203	50557708
Type 1 diabetes mellitus	25.46	10.81	22	47191	3091	50554820
Therapeutic product effect incomplete	25.10	10.81	29	47184	91486	50466425
Fracture blisters	24.36	10.81	7	47206	79	50557832
Dyslipidaemia	24.35	10.81	29	47184	5959	50551952
Accidental underdose	24.29	10.81	12	47201	646	50557265
Anal atresia	23.48	10.81	10	47203	381	50557530
Vomiting	23.24	10.81	578	46635	460180	50097731
International normalised ratio abnormal	23.06	10.81	20	47193	2823	50555088
Cystic fibrosis	22.93	10.81	20	47193	2844	50555067
Device failure	22.86	10.81	27	47186	5501	50552410
Impaired gastric emptying	22.77	10.81	34	47179	8684	50549227
Nasopharyngitis	22.49	10.81	98	47115	192829	50365082
Bicuspid aortic valve	22.36	10.81	7	47206	108	50557803
Cerebrovascular accident	22.26	10.81	158	47055	94522	50463389
Hospitalisation	21.31	10.81	122	47091	67815	50490096
Mobility decreased	21.21	10.81	26	47187	79922	50477989
Diabetic hyperosmolar coma	20.72	10.81	9	47204	360	50557551
Off label use	20.65	10.81	315	46898	474111	50083800
Acute myocardial infarction	20.45	10.81	67	47146	29206	50528705
Hyperhidrosis	20.31	10.81	148	47065	89278	50468633
Caesarean section	20.28	10.81	45	47168	15594	50542317
Neonatal respiratory distress syndrome	20.19	10.81	18	47195	2636	50555275
Meningomyelocele	19.86	10.81	10	47203	561	50557350
Large intestine polyp	19.73	10.81	29	47184	7303	50550608
Flank pain	19.62	10.81	40	47173	13075	50544836
Dialysis	19.41	10.81	33	47180	9405	50548506
Umbilical cord abnormality	19.34	10.81	10	47203	593	50557318
Rash	19.19	10.81	290	46923	437181	50120730
Depressive symptom	19.15	10.81	19	47194	3181	50554730
Gastrointestinal disorder	19.04	10.81	37	47176	94419	50463492
Productive cough	18.79	10.81	98	47115	52596	50505315
Hip arthroplasty	18.65	10.81	3	47210	30426	50527485
Dyspnoea	18.61	10.81	654	46559	546954	50010957
Premature delivery	18.22	10.81	56	47157	23607	50534304
Spina bifida	17.98	10.81	10	47203	687	50557224
Shoulder dystocia	17.93	10.81	3	47210	0	50557911
Hyperglycaemic unconsciousness	17.93	10.81	3	47210	0	50557911
Diabetic ketoacidotic hyperglycaemic coma	17.77	10.81	5	47208	52	50557859
Fear-related avoidance of activities	17.67	10.81	6	47207	121	50557790
Restless legs syndrome	17.61	10.81	43	47170	15854	50542057
Abscess	17.32	10.81	40	47173	14232	50543679
Fatigue	17.26	10.81	516	46697	707085	49850826
Exomphalos	17.25	10.81	9	47204	544	50557367
Congenital anomaly	17.22	10.81	13	47200	1508	50556403
Knee arthroplasty	17.14	10.81	6	47207	35840	50522071
Decreased insulin requirement	17.14	10.81	6	47207	133	50557778
Device operational issue	16.88	10.81	7	47206	249	50557662
Product use issue	16.76	10.81	77	47136	149398	50408513
Hypervolaemia	16.61	10.81	57	47156	25442	50532469
Abdominal pain	16.58	10.81	311	46902	235917	50321994
Blood ketone body increased	16.53	10.81	7	47206	263	50557648
Hepatic enzyme increased	16.48	10.81	69	47144	137311	50420600
Hypoglycaemic encephalopathy	16.33	10.81	7	47206	271	50557640
Maculopathy	16.24	10.81	14	47199	1960	50555951
Impaired healing	16.20	10.81	25	47188	69761	50488150
Appetite disorder	16.19	10.81	24	47189	6090	50551821
Diabetic hepatopathy	15.86	10.81	3	47210	3	50557908
Foetal hypokinesia	15.78	10.81	8	47205	455	50557456
White blood cell count decreased	15.68	10.81	56	47157	116666	50441245
Product container issue	15.68	10.81	12	47201	1420	50556491
Rhabdomyolysis	15.62	10.81	75	47138	38952	50518959
Product dispensing error	15.60	10.81	29	47184	8862	50549049
Product administration error	15.52	10.81	47	47166	19652	50538259
Acute painful neuropathy of rapid glycaemic control	15.40	10.81	3	47210	4	50557907
Pemphigoid	15.38	10.81	23	47190	5884	50552027
Device expulsion	15.27	10.81	4	47209	28818	50529093
Hepatic encephalopathy	15.15	10.81	30	47183	9606	50548305
Lymphoedema	15.07	10.81	29	47184	9093	50548818
Headache	15.04	10.81	359	46854	506176	50051735
Resting tremor	14.96	10.81	9	47204	717	50557194
Sputum increased	14.87	10.81	13	47200	1854	50556057
Extradural haematoma	14.59	10.81	12	47201	1575	50556336
Systemic infection	14.49	10.81	14	47199	2269	50555642
Loss of consciousness	14.47	10.81	155	47058	104198	50453713
Immunosuppressant drug level increased	14.34	10.81	16	47197	3066	50554845
Diabetic foot	14.33	10.81	11	47202	1307	50556604
Blister	14.32	10.81	37	47176	85381	50472530
Left ventricular hypertrophy	14.27	10.81	20	47193	4825	50553086
Cholestasis	14.18	10.81	54	47159	25347	50532564
Carcinoid crisis	14.18	10.81	6	47207	225	50557686
Angina pectoris	14.07	10.81	55	47158	26133	50531778
Intentional overdose	13.93	10.81	103	47110	62401	50495510
High risk pregnancy	13.79	10.81	5	47208	123	50557788
Urinary tract infection	13.73	10.81	289	46924	223731	50334180
Hyperglycaemic hyperosmolar nonketotic syndrome	13.59	10.81	8	47205	612	50557299
Fluid retention	13.37	10.81	87	47126	50562	50507349
Mental status changes	13.31	10.81	68	47145	36204	50521707
Rales	13.27	10.81	29	47184	9949	50547962
Anti-insulin antibody increased	13.13	10.81	4	47209	56	50557855
Splenic thrombosis	13.12	10.81	3	47210	12	50557899
Infection	13.08	10.81	101	47112	172853	50385058
Conjoined twins	13.07	10.81	6	47207	274	50557637
Therapeutic response decreased	12.91	10.81	15	47198	47216	50510695
Ataxia	12.91	10.81	35	47178	13751	50544160
Oedema peripheral	12.87	10.81	213	47000	157748	50400163
Renal hypertension	12.86	10.81	5	47208	150	50557761
Macrosomia	12.82	10.81	4	47209	61	50557850
Incorrect dose administered by device	12.79	10.81	16	47197	3459	50554452
Multiple lentigines syndrome	12.77	10.81	5	47208	153	50557758
Diabetic coma	12.71	10.81	8	47205	691	50557220
Sopor	12.57	10.81	44	47169	19835	50538076
Retinopathy	12.48	10.81	14	47199	2698	50555213
Malaise	12.44	10.81	405	46808	335127	50222784
Foetal macrosomia	12.36	10.81	4	47209	69	50557842
Congenital aortic valve stenosis	12.36	10.81	4	47209	69	50557842
Diabetic retinal oedema	12.20	10.81	6	47207	320	50557591
Bursitis	11.87	10.81	3	47210	22132	50535779
Pancreas transplant	11.84	10.81	3	47210	20	50557891
Pancreatic carcinoma	11.83	10.81	21	47192	6193	50551718
Cardiac septal hypertrophy	11.80	10.81	5	47208	188	50557723
Jaundice neonatal	11.62	10.81	8	47205	803	50557108
Blood ketone body present	11.59	10.81	3	47210	22	50557889
Drug abuse	11.58	10.81	24	47189	59822	50498089
Haemodialysis complication	11.56	10.81	5	47208	198	50557713
Incorrect dose administered	11.49	10.81	81	47132	48333	50509578
Polymorphic light eruption	11.37	10.81	3	47210	24	50557887
Adrenal adenoma	11.34	10.81	8	47205	835	50557076
Glucose-6-phosphate dehydrogenase deficiency	11.30	10.81	5	47208	209	50557702
Hip fracture	11.24	10.81	51	47162	25880	50532031
Hepatocellular injury	11.22	10.81	51	47162	25896	50532015
Selective eating disorder	11.19	10.81	11	47202	1821	50556090
Cellulitis	11.17	10.81	108	47105	70690	50487221
Therapy non-responder	11.16	10.81	19	47194	51003	50506908
Neutrophil count decreased	11.15	10.81	16	47197	46010	50511901
Febrile neutropenia	11.13	10.81	50	47163	97617	50460294
Dermo-hypodermitis	10.96	10.81	5	47208	225	50557686
Intentional product use issue	10.94	10.81	36	47177	76882	50481029
Anogenital warts	10.93	10.81	6	47207	402	50557509
Eczema	10.86	10.81	46	47167	22656	50535255

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoglycaemia	1086.55	10.71	742	41985	47604	29484196
Blood glucose increased	624.31	10.71	582	42145	58402	29473398
Diabetic ketoacidosis	613.12	10.71	346	42381	15727	29516073
Blood glucose decreased	342.99	10.71	215	42512	11854	29519946
Diabetes mellitus inadequate control	257.07	10.71	180	42547	11954	29519846
Hyperglycaemia	237.96	10.71	270	42457	34017	29497783
Hypoglycaemic unconsciousness	205.24	10.71	66	42661	697	29531103
Hypoglycaemic coma	179.37	10.71	79	42648	2084	29529716
Blood glucose fluctuation	174.80	10.71	91	42636	3506	29528294
Appendicolith	132.78	10.71	75	42652	3405	29528395
Ketoacidosis	93.82	10.71	61	42666	3578	29528222
Drug abuse	88.93	10.71	7	42720	79876	29451924
Toxicity to various agents	84.49	10.71	76	42651	173585	29358215
Glycosylated haemoglobin increased	84.34	10.71	85	42642	9341	29522459
Appendicitis	76.42	10.71	78	42649	8701	29523099
Acute kidney injury	70.16	10.71	636	42091	264631	29267169
Diabetic retinopathy	67.88	10.71	37	42690	1565	29530235
Product quality issue	67.23	10.71	98	42629	15797	29516003
Diabetic metabolic decompensation	66.44	10.71	35	42692	1381	29530419
Blood glucose abnormal	65.14	10.71	56	42671	5027	29526773
Hypoglycaemic seizure	64.20	10.71	22	42705	287	29531513
Completed suicide	62.59	10.71	26	42701	90220	29441580
Drug ineffective	55.90	10.71	303	42424	362867	29168933
Product leakage	53.89	10.71	21	42706	402	29531398
Anti-insulin antibody positive	52.90	10.71	17	42710	179	29531621
Ascites	50.21	10.71	141	42586	36478	29495322
Cardiogenic shock	46.13	10.71	92	42635	19098	29512702
Hypoglycaemia neonatal	44.69	10.71	29	42698	1695	29530105
Stress	43.47	10.71	96	42631	21394	29510406
Abdominal distension	42.99	10.71	155	42572	45756	29486044
Device malfunction	39.73	10.71	55	42672	8452	29523348
Hyperkalaemia	38.34	10.71	183	42544	61209	29470591
Wrong product administered	35.39	10.71	38	42689	4493	29527307
Diabetic neuropathy	32.03	10.71	33	42694	3720	29528080
Liquid product physical issue	29.90	10.71	13	42714	332	29531468
Diabetic foot	29.59	10.71	25	42702	2191	29529609
Periodontitis	29.55	10.71	23	42704	1794	29530006
Pulmonary valve stenosis congenital	29.28	10.71	10	42717	129	29531671
Vomiting	28.71	10.71	448	42279	211812	29319988
Chronic kidney disease	27.59	10.71	115	42612	36301	29495499
Insulin resistance	27.35	10.71	14	42713	520	29531280
Hypoglycaemia unawareness	27.33	10.71	9	42718	103	29531697
Diabetic nephropathy	26.59	10.71	22	42705	1873	29529927
Cutaneous amyloidosis	26.30	10.71	7	42720	35	29531765
Infective pulmonary exacerbation of cystic fibrosis	25.71	10.71	38	42689	6198	29525602
Lymphangitis	24.51	10.71	13	42714	520	29531280
Diabetic ketoacidotic hyperglycaemic coma	24.41	10.71	9	42718	147	29531653
Gallbladder neoplasm	23.43	10.71	6	42721	25	29531775
Insulin autoimmune syndrome	23.08	10.71	10	42717	253	29531547
Febrile neutropenia	22.98	10.71	84	42643	112156	29419644
Diabetic macroangiopathy	22.94	10.71	5	42722	8	29531792
Pemphigoid	22.78	10.71	40	42687	7541	29524259
Foetal exposure during pregnancy	22.63	10.71	103	42624	33764	29498036
Cystic fibrosis	22.36	10.71	18	42709	1474	29530326
Hypoglycaemic encephalopathy	22.21	10.71	10	42717	278	29531522
Diabetic complication	21.86	10.71	13	42714	650	29531150
Loss of consciousness	21.75	10.71	182	42545	73874	29457926
Bronchopneumopathy	21.68	10.71	11	42716	401	29531399
Vitreous haemorrhage	21.48	10.71	20	42707	1993	29529807
Diabetes mellitus	20.16	10.71	112	42615	39719	29492081
Congenital bladder anomaly	19.54	10.71	9	42718	264	29531536
Congenital cystic kidney disease	19.16	10.71	10	42717	387	29531413
Product use in unapproved indication	19.13	10.71	63	42664	86812	29444988
Anti-insulin antibody	19.13	10.71	5	42722	23	29531777
Sepsis	18.81	10.71	300	42427	142382	29389418
Genitalia external ambiguous	18.37	10.71	8	42719	205	29531595
Wrong technique in device usage process	18.22	10.71	14	42713	1071	29530729
Therapeutic product effect incomplete	18.12	10.71	18	42709	39287	29492513
Treatment failure	18.11	10.71	16	42711	36923	29494877
Diabetic coma	17.51	10.71	12	42715	768	29531032
Death	17.30	10.71	370	42357	341714	29190086
Infusion related reaction	17.10	10.71	23	42704	43863	29487937
General physical health deterioration	17.01	10.71	225	42502	102632	29429168
Hallucination	16.85	10.71	24	42703	44688	29487112
Pancreatitis	16.77	10.71	96	42631	34418	29497382
Renal aplasia	16.76	10.71	11	42716	655	29531145
Gingival hypertrophy	16.73	10.71	16	42711	1649	29530151
Aggression	16.71	10.71	16	42711	35525	29496275
Toe amputation	16.70	10.71	18	42709	2137	29529663
Adenocarcinoma pancreas	16.67	10.71	14	42713	1217	29530583
Diabetic ketosis	16.56	10.71	6	42721	93	29531707
Osteitis	16.46	10.71	15	42712	1454	29530346
Hepatic cirrhosis	16.36	10.71	52	42675	14392	29517408
Disease progression	16.30	10.71	62	42665	81854	29449946
Incorrect dose administered	16.20	10.71	92	42635	32892	29498908
Impaired gastric emptying	16.09	10.71	21	42706	3049	29528751
Fine motor skill dysfunction	15.76	10.71	15	42712	1536	29530264
Product administration error	15.74	10.71	51	42676	14259	29517541
Product physical issue	15.41	10.71	17	42710	2071	29529729
Diabetic foot infection	15.07	10.71	10	42717	607	29531193
Hyperinsulinaemic hypoglycaemia	14.97	10.71	5	42722	60	29531740
Cardiac output decreased	14.60	10.71	11	42716	817	29530983
Polycythaemia neonatorum	14.55	10.71	3	42724	3	29531797
Ventricular fibrillation	14.42	10.71	53	42674	15780	29516020
Hepatotoxicity	14.36	10.71	4	42723	17863	29513937
Condition aggravated	14.17	10.71	139	42588	146156	29385644
Cold sweat	14.08	10.71	36	42691	8806	29522994
Foetal hypokinesia	14.02	10.71	8	42719	370	29531430
Blood ketone body increased	13.94	10.71	8	42719	374	29531426
Truncus arteriosus persistent	13.89	10.71	4	42723	28	29531772
Skin ulcer	13.88	10.71	59	42668	18781	29513019
Hyponatraemia	13.81	10.71	154	42573	67479	29464321
Dry gangrene	13.77	10.71	8	42719	383	29531417
Herpes zoster reactivation	13.60	10.71	7	42720	263	29531537
Treatment noncompliance	13.53	10.71	70	42657	24157	29507643
Neonatal respiratory depression	13.38	10.71	8	42719	404	29531396
Ketosis	13.19	10.71	8	42719	415	29531385
Product complaint	13.09	10.71	26	42701	5379	29526421
Overdose	13.08	10.71	65	42662	79754	29452046
Nausea	13.05	10.71	526	42201	288729	29243071
Trisomy 18	12.60	10.71	6	42721	190	29531610
Spermatic cord disorder	12.48	10.71	3	42724	9	29531791
Pneumobilia	12.37	10.71	4	42723	43	29531757
Heart disease congenital	12.29	10.71	12	42715	1268	29530532
Drug resistance	12.26	10.71	8	42719	21532	29510268
Postprandial hypoglycaemia	12.24	10.71	3	42724	10	29531790
Anxiety	12.08	10.71	73	42654	85292	29446508
Hyperhidrosis	11.86	10.71	144	42583	64396	29467404
Basophil count abnormal	11.81	10.71	3	42724	12	29531788
Hunger	11.76	10.71	12	42715	1337	29530463
Abdominal pain	11.76	10.71	267	42460	135090	29396710
Product label issue	11.72	10.71	6	42721	223	29531577
Hepatocellular carcinoma	11.57	10.71	29	42698	7009	29524791
Insulin-requiring type 2 diabetes mellitus	11.56	10.71	5	42722	126	29531674
Cellulitis	11.56	10.71	109	42618	45731	29486069
Neutrophil count decreased	11.48	10.71	29	42698	43538	29488262
Hydrops foetalis	11.45	10.71	6	42721	234	29531566
Funguria	11.41	10.71	4	42723	56	29531744
Pancreatic carcinoma	11.27	10.71	29	42698	7121	29524679
Gangrene	11.08	10.71	21	42706	4197	29527603
Mucosal inflammation	10.91	10.71	18	42709	31577	29500223
Device failure	10.89	10.71	14	42713	2002	29529798
Peritonitis bacterial	10.84	10.71	25	42702	5731	29526069
Euglycaemic diabetic ketoacidosis	10.80	10.71	16	42711	2614	29529186
Haemolytic anaemia	10.75	10.71	34	42693	9385	29522415

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoglycaemia	2061.27	9.91	1291	74144	88601	64334696
Diabetic ketoacidosis	1678.67	9.91	779	74656	29066	64394231
Blood glucose increased	1395.45	9.91	1050	74385	97023	64326274
Blood glucose decreased	623.14	9.91	369	75066	22754	64400543
Hyperglycaemia	552.21	9.91	503	74932	60465	64362832
Diabetes mellitus inadequate control	499.28	9.91	311	75124	21010	64402287
Hypoglycaemic unconsciousness	321.85	9.91	97	75338	1024	64422273
Hypoglycaemic coma	321.70	9.91	137	75298	4137	64419160
Blood glucose fluctuation	263.41	9.91	132	75303	5823	64417474
Ketoacidosis	262.68	9.91	138	75297	6725	64416572
Acute kidney injury	219.13	9.91	1071	74364	448169	63975128
Diabetic retinopathy	213.65	9.91	91	75344	2748	64420549
Glycosylated haemoglobin increased	212.84	9.91	165	75270	15854	64407443
Product leakage	184.88	9.91	56	75379	602	64422695
Diabetic metabolic decompensation	177.76	9.91	79	75356	2649	64420648
Product quality issue	158.81	9.91	185	75250	29614	64393683
Appendicolith	147.87	9.91	75	75360	3394	64419903
Drug ineffective	143.71	9.91	504	74931	839743	63583554
Completed suicide	129.86	9.91	50	75385	224364	64198933
Toxicity to various agents	129.07	9.91	141	75294	363372	64059925
Blood glucose abnormal	123.19	9.91	94	75341	8819	64414478
Hypoglycaemic seizure	112.76	9.91	40	75395	728	64422569
Anti-insulin antibody positive	96.21	9.91	28	75407	259	64423038
Hypoglycaemia unawareness	90.15	9.91	24	75411	154	64423143
Drug intolerance	84.75	9.91	58	75377	187934	64235363
Synovitis	83.97	9.91	9	75426	99081	64324216
Diabetic neuropathy	83.92	9.91	62	75373	5539	64417758
Infusion related reaction	82.13	9.91	45	75390	164422	64258875
Liquid product physical issue	80.39	9.91	32	75403	810	64422487
Arthropathy	78.63	9.91	22	75413	120945	64302352
Drug abuse	77.35	9.91	29	75406	132345	64290952
Hyperkalaemia	77.17	9.91	277	75158	100852	64322445
Infective pulmonary exacerbation of cystic fibrosis	72.68	9.91	79	75356	11717	64411580
Appendicitis	71.88	9.91	84	75351	13485	64409812
Joint swelling	71.53	9.91	88	75347	215294	64208003
Diabetic ketosis	65.28	9.91	22	75413	341	64422956
Treatment failure	62.75	9.91	29	75406	116787	64306510
Wrong product administered	62.68	9.91	60	75375	7660	64415637
Hyper IgE syndrome	62.27	9.91	23	75412	472	64422825
Hand deformity	60.86	9.91	3	75432	62768	64360529
Arthralgia	59.79	9.91	290	75145	441970	63981327
Pain	59.66	9.91	391	75044	553120	63870177
Exposure during pregnancy	57.75	9.91	211	75224	77464	64345833
Ketosis	57.01	9.91	26	75409	927	64422370
Rheumatoid arthritis	56.81	9.91	65	75370	164229	64259068
Systemic lupus erythematosus	56.60	9.91	11	75424	77601	64345696
Alopecia	55.73	9.91	67	75368	165623	64257674
Chronic kidney disease	55.16	9.91	171	75264	57748	64365549
Contraindicated product administered	53.09	9.91	30	75405	107799	64315498
Diabetic nephropathy	50.50	9.91	34	75401	2620	64420677
Insulin resistance	50.46	9.91	25	75410	1075	64422222
Glossodynia	47.53	9.91	9	75426	64687	64358610
Vomiting	46.46	9.91	903	74532	550214	63873083
Euglycaemic diabetic ketoacidosis	45.74	9.91	43	75392	5367	64417930
Drug hypersensitivity	44.26	9.91	137	75298	237678	64185619
Sinusitis	43.97	9.91	64	75371	145864	64277433
Therapeutic product effect decreased	43.96	9.91	42	75393	115309	64307988
Product physical issue	42.52	9.91	34	75401	3415	64419882
Diabetic ketoacidotic hyperglycaemic coma	41.90	9.91	14	75421	211	64423086
Abdominal distension	40.35	9.91	220	75215	95774	64327523
Pemphigoid	39.02	9.91	61	75374	12925	64410372
Device malfunction	38.66	9.91	72	75363	17561	64405736
Cystic fibrosis	38.43	9.91	32	75403	3402	64419895
Oesophageal spasm	37.94	9.91	28	75407	2497	64420800
Therapeutic product effect incomplete	37.91	9.91	39	75396	103443	64319854
Diabetic foot	37.85	9.91	30	75405	2975	64420322
Pancreatitis	37.81	9.91	154	75281	59453	64363844
Diabetes mellitus	37.72	9.91	166	75269	66308	64356989
Cardiogenic shock	35.88	9.91	101	75334	32326	64390971
Heart sounds	34.66	9.91	16	75419	587	64422710
Lactic acidosis	34.57	9.91	153	75282	61257	64362040
Ascites	34.55	9.91	154	75281	61847	64361450
Hypoglycaemic encephalopathy	34.43	9.91	16	75419	596	64422701
Abdominal discomfort	33.93	9.91	105	75330	182217	64241080
Hyperhidrosis	33.77	9.91	256	75179	124664	64298633
Product administration error	33.48	9.91	89	75346	27554	64395743
Ketonuria	33.18	9.91	19	75416	1098	64422199
Nasopharyngitis	33.00	9.91	118	75317	195955	64227342
Pericarditis	32.83	9.91	16	75419	62500	64360797
Abdominal pain	32.71	9.91	530	74905	311845	64111452
Polycystic ovaries	32.61	9.91	24	75411	2131	64421166
Restrictive pulmonary disease	32.44	9.91	24	75411	2148	64421149
Insulin autoimmune syndrome	32.05	9.91	13	75422	346	64422951
Loss of consciousness	32.04	9.91	289	75146	148076	64275221
Cutaneous amyloidosis	31.57	9.91	8	75427	41	64423256
Helicobacter infection	31.21	9.91	4	75431	38358	64384939
Blood ketone body increased	30.90	9.91	15	75420	617	64422680
Dehydration	30.33	9.91	387	75048	216376	64206921
Prolonged expiration	29.94	9.91	16	75419	807	64422490
Oesophageal pain	29.65	9.91	27	75408	3236	64420061
Vitreous haemorrhage	28.96	9.91	26	75409	3059	64420238
Dyslipidaemia	28.58	9.91	44	75391	9198	64414099
Musculoskeletal stiffness	28.20	9.91	64	75371	123142	64300155
Irritable bowel syndrome	27.88	9.91	5	75430	37364	64385933
Febrile neutropenia	27.09	9.91	120	75315	187537	64235760
Headache	27.08	9.91	446	74989	529021	63894276
Stress	26.28	9.91	140	75295	60394	64362903
Incorrect dose administered	26.02	9.91	140	75295	60625	64362672
Lethargy	25.70	9.91	159	75276	72435	64350862
Pre-eclampsia	25.66	9.91	34	75401	6197	64417100
Impaired gastric emptying	24.59	9.91	40	75395	8764	64414533
Product use in unapproved indication	24.27	9.91	115	75320	176503	64246794
Off label use	24.16	9.91	560	74875	632246	63791051
Blood ketone body	23.33	9.91	8	75427	131	64423166
Cold sweat	23.07	9.91	56	75379	16399	64406898
Fracture blisters	22.80	9.91	7	75428	79	64423218
Device operational issue	22.31	9.91	10	75425	342	64422955
Neutrophil count decreased	22.14	9.91	35	75400	77161	64346136
Discomfort	21.96	9.91	38	75397	80840	64342457
Hepatocellular carcinoma	21.88	9.91	37	75398	8366	64414931
Mobility decreased	21.82	9.91	42	75393	85798	64337499
Type 1 diabetes mellitus	21.77	9.91	30	75405	5675	64417622
Sepsis	21.60	9.91	384	75051	229957	64193340
Renal failure	21.57	9.91	315	75120	181373	64241924
Intentional product use issue	21.44	9.91	50	75385	95314	64327983
Treatment noncompliance	21.28	9.91	104	75331	43378	64379919
Muscle injury	20.93	9.91	3	75432	26434	64396863
Diabetic hepatopathy	20.77	9.91	4	75431	3	64423294
Lymphangitis	20.74	9.91	15	75420	1296	64422001
Folliculitis	20.43	9.91	5	75430	30072	64393225
Dyspnoea	20.36	9.91	1031	74404	717643	63705654
Device failure	20.34	9.91	29	75406	5663	64417634
Foetal macrosomia	20.24	9.91	4	75431	4	64423293
Gastrointestinal disorder	20.20	9.91	47	75388	89662	64333635
Bronchopneumopathy	20.10	9.91	11	75424	582	64422715
Coronavirus test positive	20.08	9.91	13	75422	938	64422359
Drug resistance	19.98	9.91	8	75427	35094	64388203
Hospitalisation	19.68	9.91	153	75282	75054	64348243
Respiration abnormal	19.44	9.91	30	75405	6285	64417012
C-reactive protein abnormal	19.40	9.91	5	75430	29042	64394255
Gallbladder neoplasm	19.29	9.91	6	75429	71	64423226
Decreased insulin requirement	18.94	9.91	7	75428	144	64423153
Polyuria	18.77	9.91	44	75391	12599	64410698
Blood pressure fluctuation	18.48	9.91	20	75415	51851	64371446
Cellulitis	18.48	9.91	179	75256	93478	64329819
Hepatotoxicity	18.43	9.91	12	75423	39950	64383347
Sleep apnoea syndrome	18.07	9.91	76	75359	29756	64393541
Hepatic encephalopathy	18.05	9.91	60	75375	21006	64402291
Adenocarcinoma pancreas	18.01	9.91	16	75419	1857	64421440
Myocardial infarction	17.94	9.91	283	75152	165538	64257759
Fear-related avoidance of activities	17.92	9.91	6	75429	91	64423206
Product container issue	17.89	9.91	12	75423	919	64422378
Swelling	17.78	9.91	112	75323	160106	64263191
Periodontitis	17.60	9.91	23	75412	4136	64419161
Hyperglycaemic unconsciousness	17.26	9.91	3	75432	0	64423297
Wrong technique in device usage process	17.23	9.91	19	75416	2863	64420434
Fluid retention	17.14	9.91	124	75311	59482	64363815
Hypervolaemia	16.93	9.91	89	75346	38196	64385101
Sputum increased	16.80	9.91	21	75414	3614	64419683
C-reactive protein increased	16.71	9.91	56	75379	94853	64328444
Foetal hypokinesia	16.66	9.91	8	75427	321	64422976
Anti-insulin antibody increased	16.62	9.91	6	75429	115	64423182
Lower respiratory tract infection	16.54	9.91	56	75379	94558	64328739
Hypothermia	16.52	9.91	56	75379	19800	64403497
Wound	16.48	9.91	41	75394	76436	64346861
Haemorrhagic stroke	16.29	9.91	36	75399	9915	64413382
Blood insulin increased	16.17	9.91	8	75427	343	64422954
Gangrene	16.13	9.91	30	75405	7308	64415989
Hyperinsulinaemic hypoglycaemia	15.94	9.91	6	75429	130	64423167
Pancreatitis acute	15.88	9.91	95	75340	42760	64380537
Blood ketone body present	15.86	9.91	5	75430	62	64423235
Diabetic hyperosmolar coma	15.64	9.91	10	75425	706	64422591
Hip arthroplasty	15.62	9.91	3	75432	21348	64401949
Diabetic macroangiopathy	15.49	9.91	6	75429	141	64423156
Systemic infection	15.42	9.91	22	75413	4299	64418998
Diabetic gastroparesis	15.36	9.91	7	75428	249	64423048
Insulin-requiring type 2 diabetes mellitus	15.33	9.91	6	75429	145	64423152
Anti-insulin antibody	15.30	9.91	5	75430	70	64423227
Hyperglycaemic hyperosmolar nonketotic syndrome	15.18	9.91	14	75421	1705	64421592
Hyperglycaemic seizure	15.18	9.91	3	75432	3	64423294
Arthritis	15.06	9.91	49	75386	83765	64339532
Product dispensing error	15.03	9.91	38	75397	11412	64411885
Increased insulin requirement	14.92	9.91	6	75429	156	64423141
Acute painful neuropathy of rapid glycaemic control	14.72	9.91	3	75432	4	64423293
Hypersensitivity	14.59	9.91	153	75282	196299	64226998
Gingival hypertrophy	14.54	9.91	17	75418	2730	64420567
Oedema peripheral	14.51	9.91	335	75100	209982	64213315
Injection site reaction	14.51	9.91	20	75415	46644	64376653
Dry gangrene	14.32	9.91	10	75425	818	64422479
Respiratory arrest	14.28	9.91	25	75410	52960	64370337
Product prescribing error	14.25	9.91	80	75355	35189	64388108
Disease progression	14.24	9.91	102	75333	141578	64281719
Premature delivery	14.23	9.91	51	75384	18538	64404759
Cerebrovascular accident	14.20	9.91	233	75202	137350	64285947
Poisoning	14.17	9.91	4	75431	21875	64401422
Blood cholesterol increased	14.07	9.91	23	75412	50043	64373254
Fine motor skill dysfunction	14.01	9.91	22	75413	4677	64418620
Loss of personal independence in daily activities	13.99	9.91	41	75394	72413	64350884
Product complaint	13.98	9.91	38	75397	11916	64411381
Heart rate decreased	13.94	9.91	27	75408	55040	64368257
White blood cell count decreased	13.82	9.91	118	75317	157719	64265578
Glucose-6-phosphate dehydrogenase deficiency	13.65	9.91	7	75428	324	64422973
Diabetic coma	13.62	9.91	11	75424	1120	64422177
Red blood cell sedimentation rate increased	13.58	9.91	10	75425	31225	64392072
Dialysis	13.45	9.91	47	75388	16873	64406424
Product odour abnormal	13.44	9.91	11	75424	1142	64422155
Device expulsion	13.44	9.91	4	75431	21132	64402165
Diabetic retinal oedema	13.34	9.91	7	75428	340	64422957
Malaise	13.21	9.91	578	74857	395669	64027628
Nonreassuring foetal heart rate pattern	13.11	9.91	3	75432	9	64423288
Angina pectoris	13.09	9.91	94	75341	44987	64378310
Retrograde ejaculation	13.05	9.91	6	75429	218	64423079
International normalised ratio abnormal	13.04	9.91	22	75413	4966	64418331
End stage renal disease	12.96	9.91	34	75401	10441	64412856
Therapy non-responder	12.93	9.91	37	75398	65862	64357435
Peritonitis bacterial	12.92	9.91	31	75404	9012	64414285
Cardiac failure	12.86	9.91	222	75213	132151	64291146
Adverse drug reaction	12.67	9.91	21	75414	45443	64377854
Sedation	12.66	9.91	18	75417	41444	64381853
Myelosuppression	12.66	9.91	6	75429	23824	64399473
Erythema	12.58	9.91	149	75286	186921	64236376
Infection	12.53	9.91	147	75288	184733	64238564
Hepatocellular injury	12.38	9.91	93	75342	45142	64378155
Hepatic enzyme increased	12.36	9.91	95	75340	129848	64293449
Intentional overdose	12.31	9.91	160	75275	89784	64333513
Large intestine polyp	12.23	9.91	34	75401	10803	64412494
Dialysis device insertion	12.05	9.91	4	75431	59	64423238
Swollen tongue	12.02	9.91	76	75359	34878	64388419
Fall	11.96	9.91	599	74836	416227	64007070
Acetonaemia	11.92	9.91	6	75429	267	64423030
Heart rate irregular	11.63	9.91	9	75426	27404	64395893
Mental status changes	11.62	9.91	116	75319	61046	64362251
Bone pain	11.47	9.91	24	75411	47548	64375749
Accidental underdose	11.46	9.91	8	75427	654	64422643
Hot flush	11.42	9.91	23	75412	46212	64377085
Appetite disorder	11.29	9.91	24	75411	6437	64416860
Acute myocardial infarction	11.28	9.91	128	75307	69590	64353707
Flank pain	11.21	9.91	43	75392	16146	64407151
Oral herpes	11.13	9.91	6	75429	22146	64401151
Lymphoedema	11.10	9.91	31	75404	9874	64413423
Foot amputation	11.05	9.91	8	75427	693	64422604
Cystic fibrosis related diabetes	11.02	9.91	5	75430	176	64423121
Conjunctivitis	11.01	9.91	5	75430	20349	64402948
Hypokalaemia	10.98	9.91	202	75233	121701	64301596
Condition aggravated	10.92	9.91	342	75093	372084	64051213
Ventricular fibrillation	10.92	9.91	56	75379	23804	64399493
Renal impairment	10.89	9.91	220	75215	134797	64288500
Neutropenia	10.88	9.91	206	75229	239418	64183879
Postprandial hypoglycaemia	10.88	9.91	4	75431	81	64423216
Maculopathy	10.87	9.91	14	75421	2482	64420815
Hepatic cirrhosis	10.86	9.91	60	75375	26238	64397059
Diabetic foot infection	10.83	9.91	8	75427	714	64422583
Subdural haemorrhage	10.82	9.91	21	75414	5282	64418015
Rash	10.73	9.91	433	75002	458116	63965181
High risk pregnancy	10.70	9.91	4	75431	85	64423212
Drug delivery system issue	10.69	9.91	3	75432	24	64423273
Depressive symptom	10.67	9.91	19	75416	4477	64418820
Progressive multifocal leukoencephalopathy	10.63	9.91	4	75431	18228	64405069
Incorrect dose administered by device	10.62	9.91	18	75417	4079	64419218
Multiple lentigines syndrome	10.55	9.91	5	75430	195	64423102
Basophil count abnormal	10.48	9.91	3	75432	26	64423271
Polymorphic light eruption	10.48	9.91	3	75432	26	64423271
Acute myeloid leukaemia	10.45	9.91	10	75425	27453	64395844
Glomerular filtration rate decreased	10.44	9.91	48	75387	19524	64403773
Impaired healing	10.42	9.91	36	75399	60437	64362860
Renal artery stenosis	10.42	9.91	15	75420	2954	64420343
Necrotising soft tissue infection	10.36	9.91	5	75430	203	64423094
Immunodeficiency	10.35	9.91	3	75432	16121	64407176
Eye haemorrhage	10.21	9.91	27	75408	8333	64414964
Multiple organ dysfunction syndrome	10.19	9.91	171	75264	101242	64322055
Threatened labour	10.18	9.91	7	75428	558	64422739
Leg amputation	10.16	9.91	16	75419	3411	64419886
Body mass index abnormal	10.11	9.91	5	75430	214	64423083
Rhabdomyolysis	10.08	9.91	157	75278	91569	64331728
Dyspepsia	10.05	9.91	54	75381	80258	64343039
Ill-defined disorder	9.98	9.91	23	75412	44029	64379268
Disseminated intravascular coagulation	9.92	9.91	14	75421	32334	64390963

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A10AB05	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, fast-acting
ATC	A10AD05	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
ATC	A10AD06	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
FDA CS	M0011417	Insulin
FDA EPC	N0000175453	Insulin Analog
CHEBI has role	CHEBI:35526	antidiabetic
FDA EPC	N0000175944	Insulin
MeSH PA	D007004	Hypoglycemic Agents

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Diabetes mellitus	indication	73211009	DOID:9351

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Insulin receptor	Kinase	P06213	INSR_HUMAN	AGONIST				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D04475	KEGG_DRUG
4021226	VUID
N0000148670	NUI
4017559	VANDF
4017569	VANDF
4019786	VANDF
4021226	VANDF
4021394	VANDF
CHEBI:5931	CHEBI
CHEMBL1201496	ChEMBL_ID
CHEMBL1201664	ChEMBL_ID
7541	INN_ID
DB01306	DRUGBANK_ID
D933668QVX	UNII
118984445	PUBCHEM_CID
118984375	PUBCHEM_CID
DB00030	DRUGBANK_ID
253182	RXNORM
15636	MMSL
17095	MMSL
327602	MMSL
37703	MMSL
4885	MMSL
4886	MMSL
d00262	MMSL
d04369	MMSL
d04697	MMSL
d04838	MMSL
126210001	SNOMEDCT_US
325072002	SNOMEDCT_US
388452006	SNOMEDCT_US
417423002	SNOMEDCT_US
420609005	SNOMEDCT_US
427292001	SNOMEDCT_US
96367001	SNOMEDCT_US
D061267	MESH_DESCRIPTOR_UI
C0123677	UMLSCUI
C0795635	UMLSCUI
5186	INN_ID
000869	NDDF
000870	NDDF
006518	NDDF
007992	NDDF
009607	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	0169-2100	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	29 sections
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	0169-2101	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	29 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	0169-2200	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	27 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	0169-2201	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	27 sections
Fiasp	HUMAN PRESCRIPTION DRUG LABEL	1	0169-3201	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	26 sections
Fiasp	HUMAN PRESCRIPTION DRUG LABEL	1	0169-3201	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	26 sections
Fiasp	HUMAN PRESCRIPTION DRUG LABEL	1	0169-3204	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	26 sections
Fiasp	HUMAN PRESCRIPTION DRUG LABEL	1	0169-3204	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	26 sections
Fiasp	HUMAN PRESCRIPTION DRUG LABEL	1	0169-3205	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	26 sections
Fiasp	HUMAN PRESCRIPTION DRUG LABEL	1	0169-3205	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	26 sections
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	0169-3303	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	29 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	0169-3685	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	27 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	0169-3696	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	27 sections
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	0169-6338	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	29 sections
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	0169-6339	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	29 sections
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	0169-7501	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	29 sections
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1664	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	NDA	29 sections
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1664	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	NDA	29 sections
NovoLog	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1665	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	NDA	29 sections
NovoLog	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1665	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	NDA	29 sections
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1678	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	NDA	29 sections
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1678	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	NDA	29 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	50090-2272	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	NDA	29 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	50090-2272	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	NDA	29 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	50090-2273	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	NDA	29 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	50090-2273	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	NDA	29 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4074	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	27 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4085	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	27 sections
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4500	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	28 sections
Insulin Aspart	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4955	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	28 sections