insulin aspart Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4981	116094-23-6

Description:

Molecule	Description
Synonyms: insulin aspart protamine recombinant insulin aspart protamine insulin aspart protamine crystalline insulin aspart insulin aspart recombinant novolog insulin aspart [rDNA origin] novorapid	Insulin that has been modified to contain an ASPARTIC ACID instead of a PROLINE at position 38 of the B-chain. Molecular weight: 5825.60 Formula: C256H381N65O79S6 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 2345.16 ALOGS: ROTB: None

Molecule

Description

Synonyms:

insulin aspart protamine recombinant
insulin aspart protamine
insulin aspart protamine crystalline
insulin aspart
insulin aspart recombinant
novolog
insulin aspart [rDNA origin]
novorapid

Insulin that has been modified to contain an ASPARTIC ACID instead of a PROLINE at position 38 of the B-chain.

Molecular weight: 5825.60
Formula: C256H381N65O79S6
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 2345.16
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
40	U	P
40	U	P
40	U	P

ADMET properties:

None

Approvals:

Date	Agency	Company
Sept. 20, 2019	PMDA	Novo Nordisk Pharma Ltd.
Sept. 7, 1999	EMA
June 7, 2000	FDA	NOVO NORDISK INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Diabetic ketoacidosis	1316.21	10.34	539	45432	17671	46622420
Hypoglycaemia	1233.43	10.34	729	45242	53620	46586471
Blood glucose increased	1102.08	10.34	753	45218	71260	46568831
Hyperglycaemia	368.77	10.34	293	45678	34778	46605313
Blood glucose decreased	354.95	10.34	225	45746	18667	46621424
Diabetes mellitus inadequate control	354.43	10.34	198	45773	13016	46627075
Ketoacidosis	231.81	10.34	101	45870	3854	46636237
Glycosylated haemoglobin increased	215.46	10.34	134	45837	10742	46629349
Hypoglycaemic unconsciousness	178.83	10.34	54	45917	692	46639399
Diabetic retinopathy	175.87	10.34	71	45900	2231	46637860
Hypoglycaemic coma	171.55	10.34	72	45899	2502	46637589
Exposure during pregnancy	149.01	10.34	329	45642	107883	46532208
Blood glucose fluctuation	144.54	10.34	74	45897	4072	46636019
Product leakage	143.74	10.34	39	45932	330	46639761
Acute kidney injury	121.90	10.34	507	45464	235348	46404743
Drug ineffective	111.32	10.34	323	45648	677515	45962576
Rheumatoid arthritis	94.57	10.34	60	45911	240155	46399936
Blood glucose abnormal	79.31	10.34	60	45911	6612	46633479
Completed suicide	75.12	10.34	25	45946	145895	46494196
Hypoglycaemia unawareness	73.04	10.34	18	45953	99	46639992
Hypoglycaemic seizure	72.82	10.34	25	45946	493	46639598
Diabetes mellitus	71.98	10.34	155	45816	49910	46590181
Diabetic metabolic decompensation	68.58	10.34	30	45941	1155	46638936
Diabetic neuropathy	68.32	10.34	44	45927	3745	46636346
Anti-insulin antibody positive	60.64	10.34	15	45956	84	46640007
Ketosis	59.28	10.34	21	45950	456	46639635
Hypoglycaemia neonatal	58.39	10.34	25	45946	913	46639178
Liquid product physical issue	58.18	10.34	22	45949	578	46639513
Premature baby	57.95	10.34	80	45891	18032	46622059
Drug intolerance	57.44	10.34	37	45934	147012	46493079
Diabetic ketosis	55.79	10.34	16	45955	169	46639922
Lactic acidosis	54.60	10.34	110	45861	33799	46606292
Product quality issue	54.28	10.34	113	45858	35535	46604556
Treatment failure	51.42	10.34	14	45957	93073	46547018
Toxicity to various agents	51.11	10.34	81	45890	211685	46428406
Drug hypersensitivity	50.98	10.34	102	45869	243723	46396368
Arthralgia	48.43	10.34	190	45781	364413	46275678
Pain	47.34	10.34	276	45695	476672	46163419
Arthropathy	44.47	10.34	14	45957	84686	46555405
Ketonuria	44.06	10.34	16	45955	374	46639717
Bicuspid aortic valve	43.18	10.34	12	45959	112	46639979
Pre-eclampsia	41.34	10.34	45	45926	7949	46632142
Wrong product administered	40.70	10.34	38	45933	5592	46634499
Synovitis	40.34	10.34	6	45965	61069	46579022
Joint swelling	39.60	10.34	64	45907	166009	46474082
Conjunctival abrasion	39.49	10.34	9	45962	33	46640058
Diabetic nephropathy	38.03	10.34	21	45950	1347	46638744
Euglycaemic diabetic ketoacidosis	37.81	10.34	24	45947	1992	46638099
Contraindicated product administered	37.27	10.34	16	45955	79931	46560160
Hyperkalaemia	36.98	10.34	122	45849	50587	46589504
Caesarean section	35.69	10.34	61	45910	16542	46623549
Insulin resistance	35.07	10.34	16	45955	681	46639410
Chronic kidney disease	35.03	10.34	104	45867	40767	46599324
Alopecia	34.73	10.34	67	45904	162347	46477744
Congenital aortic valve stenosis	34.30	10.34	9	45962	66	46640025
Renal failure	34.24	10.34	210	45761	113384	46526707
Type 1 diabetes mellitus	34.21	10.34	26	45945	2884	46637207
Infusion related reaction	32.51	10.34	31	45940	101177	46538914
Systemic lupus erythematosus	32.09	10.34	12	45959	65168	46574923
Neonatal respiratory distress syndrome	30.59	10.34	23	45948	2510	46637581
Infective pulmonary exacerbation of cystic fibrosis	30.54	10.34	45	45926	10762	46629329
Hyper IgE syndrome	28.41	10.34	10	45961	213	46639878
Musculoskeletal stiffness	28.13	10.34	33	45938	97960	46542131
Blood ketone body	28.03	10.34	7	45964	41	46640050
Polyuria	28.00	10.34	35	45936	7160	46632931
Therapeutic product effect incomplete	27.44	10.34	22	45949	78131	46561960
Therapeutic product effect decreased	26.88	10.34	25	45946	82576	46557515
Hypoglycaemic encephalopathy	26.15	10.34	10	45961	271	46639820
Lipodystrophy acquired	25.96	10.34	17	45954	1488	46638603
Pancreatitis	25.82	10.34	98	45873	43529	46596562
Bladder agenesis	25.27	10.34	8	45963	121	46639970
Foetal exposure during pregnancy	25.18	10.34	77	45894	30670	46609421
HELLP syndrome	25.15	10.34	14	45957	912	46639179
Cloacal exstrophy	24.80	10.34	8	45963	129	46639962
Diabetic gastroparesis	24.29	10.34	9	45962	223	46639868
Dehydration	24.28	10.34	252	45719	159288	46480803
Gastrointestinal malformation	23.93	10.34	8	45963	145	46639946
Device failure	23.21	10.34	29	45942	5930	46634161
Lethargy	22.51	10.34	105	45866	51066	46589025
Sinusitis	21.72	10.34	61	45910	129707	46510384
Anti-insulin antibody increased	21.59	10.34	6	45965	56	46640035
Congenital genital malformation	21.46	10.34	7	45964	117	46639974
Tethered cord syndrome	21.20	10.34	8	45963	209	46639882
International normalised ratio abnormal	20.88	10.34	20	45951	3039	46637052
Caudal regression syndrome	20.83	10.34	7	45964	129	46639962
Impaired gastric emptying	20.52	10.34	32	45939	8040	46632051
Genitalia external ambiguous	20.49	10.34	7	45964	136	46639955
Diabetic foot	19.97	10.34	15	45956	1635	46638456
Meconium stain	19.18	10.34	7	45964	166	46639925
Glossodynia	18.96	10.34	10	45961	44363	46595728
Atrial septal defect	18.81	10.34	27	45944	6305	46633786
Diabetic hyperosmolar coma	18.54	10.34	9	45962	441	46639650
Gastrointestinal disorder congenital	18.41	10.34	6	45965	100	46639991
Large intestine polyp	18.39	10.34	30	45941	7831	46632260
Fear-related avoidance of activities	18.25	10.34	6	45965	103	46639988
Acute painful neuropathy of rapid glycaemic control	17.77	10.34	3	45968	0	46640091
Hyperglycaemic unconsciousness	17.77	10.34	3	45968	0	46640091
Cystic fibrosis	17.76	10.34	20	45951	3668	46636423
Hospitalisation	17.73	10.34	115	45856	63270	46576821
Gastroschisis	17.70	10.34	7	45964	208	46639883
Product physical issue	17.65	10.34	23	45948	4904	46635187
Device expulsion	17.52	10.34	3	45968	27539	46612552
Loss of consciousness	16.95	10.34	172	45799	108066	46532025
Headache	16.95	10.34	351	45620	478001	46162090
Anal atresia	16.90	10.34	8	45963	371	46639720
Abdominal discomfort	16.84	10.34	84	45887	151081	46489010
Decreased insulin requirement	16.82	10.34	6	45965	133	46639958
Restrictive pulmonary disease	16.77	10.34	12	45959	1214	46638877
Acute myocardial infarction	16.70	10.34	69	45902	31855	46608236
Macrosomia	16.63	10.34	5	45966	63	46640028
Congenital ectopic bladder	16.49	10.34	5	45966	65	46640026
Nasopharyngitis	16.35	10.34	87	45884	153911	46486180
Diabetic ketoacidotic hyperglycaemic coma	16.22	10.34	5	45966	69	46640022
Blood ketone body increased	15.92	10.34	7	45964	273	46639818
Accidental underdose	15.86	10.34	9	45962	609	46639482
Cholestasis	15.57	10.34	60	45911	26833	46613258
Oesophageal spasm	15.50	10.34	14	45957	1975	46638116
Foetal hypokinesia	15.46	10.34	8	45963	450	46639641
Febrile neutropenia	15.45	10.34	45	45926	94582	46545509
Hepatic encephalopathy	15.22	10.34	32	45939	10125	46629966
Premature delivery	15.11	10.34	52	45919	22017	46618074
Pemphigoid	15.08	10.34	23	45948	5668	46634423
Resting tremor	15.06	10.34	9	45962	671	46639420
Hyperhidrosis	14.99	10.34	144	45827	89164	46550927
Product administration error	14.92	10.34	48	45923	19633	46620458
Meningomyelocele	14.86	10.34	8	45963	488	46639603
Anencephaly	14.81	10.34	6	45965	190	46639901
Congenital mitral valve incompetence	14.52	10.34	4	45967	36	46640055
Left ventricular hypertrophy	14.51	10.34	21	45950	4942	46635149
Foetal distress syndrome	14.30	10.34	11	45960	1242	46638849
Rhabdomyolysis	14.24	10.34	80	45891	41829	46598262
Retinal aneurysm	14.22	10.34	6	45965	211	46639880
Dialysis	14.16	10.34	31	45940	10085	46630006
Device operational issue	14.15	10.34	6	45965	214	46639877
Congenital anomaly	14.13	10.34	12	45959	1560	46638531
Fatigue	14.07	10.34	475	45496	608222	46031869
Maculopathy	13.87	10.34	12	45959	1599	46638492
Myocardial infarction	13.86	10.34	152	45819	97376	46542715
Mobility decreased	13.82	10.34	24	45947	60570	46579521
Multiple lentigines syndrome	13.67	10.34	6	45965	233	46639858
Carcinoid crisis	13.41	10.34	6	45965	244	46639847
Spine malformation	13.36	10.34	6	45965	246	46639845
Heart sounds	13.34	10.34	6	45965	247	46639844
Suicide attempt	13.10	10.34	96	45875	54940	46585151
Jaundice neonatal	13.09	10.34	9	45962	854	46639237
Type 2 diabetes mellitus	12.89	10.34	46	45925	19829	46620262
Immunosuppressant drug level increased	12.83	10.34	16	45955	3266	46636825
Congenital musculoskeletal anomaly	12.81	10.34	7	45964	440	46639651
Conjoined twins	12.74	10.34	6	45965	275	46639816
Oesophageal pain	12.60	10.34	14	45957	2529	46637562
Pericarditis	12.47	10.34	4	45967	23923	46616168
Foetal macrosomia	12.37	10.34	4	45967	65	46640026
High risk pregnancy	12.27	10.34	5	45966	161	46639930
Diabetic retinal oedema	12.19	10.34	7	45964	484	46639607
Pyelonephritis	12.14	10.34	38	45933	15319	46624772
White blood cell count decreased	12.13	10.34	63	45908	112168	46527923
Acidosis	12.12	10.34	31	45940	11143	46628948
Blood ketone body present	12.10	10.34	3	45968	17	46640074
Neutrophil count decreased	12.06	10.34	15	45956	43411	46596680
Intentional overdose	12.05	10.34	107	45864	64837	46575254
Abdominal pain	12.03	10.34	304	45667	229727	46410364
Cerebrovascular accident	11.94	10.34	152	45819	100887	46539204
Injection site abscess	11.91	10.34	9	45962	990	46639101
Hyperglycaemic hyperosmolar nonketotic syndrome	11.68	10.34	7	45964	524	46639567
Polyhydramnios	11.66	10.34	12	45959	1987	46638104
Vomiting	11.65	10.34	551	45420	452243	46187848
Death	11.62	10.34	247	45724	335301	46304790
Exomphalos	11.59	10.34	7	45964	532	46639559
Lipoatrophy	11.54	10.34	6	45965	341	46639750
Diabetic coma	11.53	10.34	8	45963	770	46639321
Pancreas transplant	11.43	10.34	3	45968	22	46640069
Polymorphic light eruption	11.43	10.34	3	45968	22	46640069
Pancreatic carcinoma	11.43	10.34	22	45949	6535	46633556
Fluid overload	11.38	10.34	55	45916	27130	46612961
Neural tube defect	11.37	10.34	5	45966	195	46639896
Polycystic ovaries	11.29	10.34	10	45961	1374	46638717
Bone pain	11.22	10.34	18	45953	46872	46593219
Incorrect dose administered	11.16	10.34	80	45891	45470	46594621
Blood pressure diastolic decreased	11.09	10.34	35	45936	14176	46625915
Prolonged expiration	10.99	10.34	6	45965	376	46639715
Glucose-6-phosphate dehydrogenase deficiency	10.96	10.34	5	45966	213	46639878
Bursitis	10.92	10.34	3	45968	19839	46620252
Anogenital warts	10.91	10.34	6	45965	382	46639709
Umbilical cord abnormality	10.88	10.34	7	45964	595	46639496
Therapeutic response decreased	10.87	10.34	16	45955	43129	46596962
Product container issue	10.86	10.34	11	45960	1788	46638303
Sleep apnoea syndrome	10.84	10.34	47	45924	22154	46617937
Adrenal adenoma	10.73	10.34	8	45963	862	46639229
Knee arthroplasty	10.61	10.34	5	45966	23660	46616431
Sepsis neonatal	10.61	10.34	6	45965	403	46639688
Median nerve injury	10.61	10.34	3	45968	30	46640061
Ataxia	10.59	10.34	34	45937	13896	46626195
Off label use	10.57	10.34	289	45682	379552	46260539
Cataract subcapsular	10.49	10.34	7	45964	632	46639459
Device malfunction	10.49	10.34	33	45938	13341	46626750
Drug abuse	10.46	10.34	30	45941	63378	46576713
Hepatocellular injury	10.46	10.34	57	45914	29465	46610626
Hypothermia	10.43	10.34	31	45940	12152	46627939

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoglycaemia	1185.32	10.40	795	41928	50186	29859569
Blood glucose increased	605.88	10.40	580	42143	60950	29848805
Diabetic ketoacidosis	605.41	10.40	341	42382	15645	29894110
Blood glucose decreased	303.39	10.40	204	42519	12849	29896906
Diabetes mellitus inadequate control	302.75	10.40	202	42521	12560	29897195
Hypoglycaemic unconsciousness	226.21	10.40	72	42651	744	29909011
Hypoglycaemic coma	213.57	10.40	91	42632	2240	29907515
Hyperglycaemia	213.37	10.40	257	42466	34943	29874812
Blood glucose fluctuation	165.86	10.40	88	42635	3573	29906182
Ketoacidosis	100.30	10.40	64	42659	3682	29906073
Glycosylated haemoglobin increased	88.46	10.40	87	42636	9404	29900351
Drug abuse	82.60	10.40	10	42713	82062	29827693
Anti-insulin antibody positive	81.18	10.40	24	42699	189	29909566
Toxicity to various agents	79.91	10.40	81	42642	177102	29732653
Diabetic retinopathy	79.08	10.40	42	42681	1708	29908047
Completed suicide	73.66	10.40	25	42698	99467	29810288
Acute kidney injury	73.47	10.40	652	42071	273190	29636565
Hypoglycaemic seizure	72.46	10.40	24	42699	284	29909471
Hypoglycaemia neonatal	55.11	10.40	32	42691	1551	29908204
Blood glucose abnormal	54.28	10.40	51	42672	5208	29904547
Diabetic metabolic decompensation	51.66	10.40	29	42694	1317	29908438
Product leakage	50.81	10.40	19	42704	328	29909427
Hyperkalaemia	46.48	10.40	202	42521	65808	29843947
Drug ineffective	46.00	10.40	291	42432	340096	29569659
Appendicolith	44.21	10.40	23	42700	896	29908859
Product quality issue	43.52	10.40	88	42635	18686	29891069
Wrong product administered	42.41	10.40	42	42681	4576	29905179
Hypoglycaemia unawareness	38.88	10.40	12	42711	111	29909644
Device malfunction	37.74	10.40	52	42671	8059	29901696
Diabetic nephropathy	35.89	10.40	26	42697	1843	29907912
Hypoglycaemic encephalopathy	34.89	10.40	13	42710	222	29909533
Anti-insulin antibody	33.38	10.40	8	42715	24	29909731
Diabetes mellitus	33.28	10.40	133	42590	41732	29868023
Periodontitis	31.09	10.40	23	42700	1684	29908071
Cutaneous amyloidosis	30.85	10.40	8	42715	36	29909719
Loss of consciousness	29.43	10.40	204	42519	79171	29830584
Diabetic foot	29.06	10.40	27	42696	2718	29907037
Pulmonary valve stenosis congenital	28.66	10.40	10	42713	140	29909615
Diabetic neuropathy	27.44	10.40	31	42692	3928	29905827
Vitreous haemorrhage	26.79	10.40	23	42700	2087	29907668
Death	25.47	10.40	358	42365	356925	29552830
Insulin autoimmune syndrome	24.17	10.40	10	42713	228	29909527
Gallbladder neoplasm	23.51	10.40	6	42717	25	29909730
Pemphigoid	23.35	10.40	40	42683	7488	29902267
Chronic kidney disease	23.05	10.40	111	42612	37727	29872028
Diabetic macroangiopathy	23.00	10.40	5	42718	8	29909747
Liquid product physical issue	22.44	10.40	10	42713	275	29909480
Product complaint	22.31	10.40	34	42689	5772	29903983
Insulin resistance	21.28	10.40	12	42711	550	29909205
Diabetic coma	20.89	10.40	14	42709	875	29908880
Vomiting	20.81	10.40	434	42289	219384	29690371
Congenital cystic kidney disease	20.50	10.40	10	42713	339	29909416
Diabetic ketoacidotic hyperglycaemic coma	20.26	10.40	8	42715	161	29909594
Pancreatitis	19.38	10.40	103	42620	36387	29873368
Congenital bladder anomaly	18.67	10.40	9	42714	297	29909458
Hyperkinetic heart syndrome	18.50	10.40	7	42716	125	29909630
Diabetic complication	18.11	10.40	13	42710	908	29908847
Cystic fibrosis	17.83	10.40	19	42704	2255	29907500
Genitalia external ambiguous	17.49	10.40	8	42715	234	29909521
Adenocarcinoma pancreas	17.45	10.40	15	42708	1363	29908392
Pancreatic carcinoma	17.29	10.40	36	42687	7801	29901954
Gingival hypertrophy	17.16	10.40	16	42707	1617	29908138
Febrile neutropenia	17.15	10.40	86	42637	106607	29803148
Dry gangrene	17.09	10.40	8	42715	247	29909508
Agranulocytosis	16.86	10.40	69	42654	21873	29887882
Ketosis	16.81	10.40	9	42714	372	29909383
Renal aplasia	16.71	10.40	11	42712	667	29909088
Lymphangitis	16.62	10.40	10	42713	518	29909237
Treatment failure	16.58	10.40	15	42708	34664	29875091
Product use in unapproved indication	16.55	10.40	52	42671	73641	29836114
Hepatotoxicity	16.42	10.40	3	42720	18142	29891613
Hyperinsulinaemic hypoglycaemia	16.13	10.40	5	42718	47	29909708
Wrong technique in device usage process	15.52	10.40	12	42711	939	29908816
Incorrect dose administered	15.19	10.40	87	42636	31599	29878156
Rheumatoid arthritis	15.16	10.40	22	42701	41175	29868580
Skin ulcer	15.06	10.40	60	42663	18789	29890966
Foetal exposure during pregnancy	14.99	10.40	97	42626	36774	29872981
Cystic fibrosis related diabetes	14.62	10.40	6	42717	134	29909621
Toe amputation	14.61	10.40	17	42706	2224	29907531
Therapeutic product effect incomplete	14.61	10.40	16	42707	33818	29875937
Polycythaemia neonatorum	14.59	10.40	3	42720	3	29909752
Cardiac output decreased	14.22	10.40	11	42712	861	29908894
Blood ketone body increased	14.20	10.40	8	42715	366	29909389
Foetal hypokinesia	14.14	10.40	8	42715	369	29909386
Infective pulmonary exacerbation of cystic fibrosis	14.04	10.40	35	42688	8537	29901218
Insomnia	14.01	10.40	77	42646	93259	29816496
Truncus arteriosus persistent	13.82	10.40	4	42719	29	29909726
Diabetic foot infection	13.81	10.40	10	42713	708	29909047
Hypospadias	13.72	10.40	18	42705	2661	29907094
Hepatic encephalopathy	13.70	10.40	48	42675	14144	29895611
Lichen myxoedematosus	13.38	10.40	3	42720	6	29909749
Product physical issue	13.36	10.40	16	42707	2158	29907597
Product administration error	13.34	10.40	48	42675	14329	29895426
Neonatal respiratory depression	13.11	10.40	8	42715	425	29909330
Anxiety	13.02	10.40	75	42648	89796	29819959
Hepatic cirrhosis	12.84	10.40	51	42672	15948	29893807
Infusion related reaction	12.75	10.40	24	42699	40540	29869215
Heart disease congenital	12.60	10.40	12	42711	1246	29908509
Gangrene	12.36	10.40	23	42700	4591	29905164
Aggression	12.36	10.40	21	42702	36886	29872869
Appendicitis	12.15	10.40	27	42696	6117	29903638
Pneumobilia	12.03	10.40	4	42719	48	29909707
Jaundice neonatal	12.02	10.40	11	42712	1086	29908669
Disease progression	11.93	10.40	66	42657	79808	29829947
Eye haemorrhage	11.90	10.40	20	42703	3687	29906068
Device failure	11.89	10.40	15	42708	2133	29907622
Treatment noncompliance	11.89	10.40	69	42654	25184	29884571
Oedematous pancreatitis	11.84	10.40	7	42716	351	29909404
Postprandial hypoglycaemia	11.66	10.40	3	42720	13	29909742
Malaise	11.60	10.40	316	42407	166646	29743109
Drug withdrawal syndrome	11.49	10.40	7	42716	19802	29889953
Trisomy 18	11.46	10.40	6	42717	237	29909518
Hallucination	11.45	10.40	34	42689	49025	29860730
Spermatic cord disorder	11.31	10.40	3	42720	15	29909740
Impaired gastric emptying	11.24	10.40	18	42705	3188	29906567
Headache	11.11	10.40	188	42535	182118	29727637
Shock haemorrhagic	10.97	10.40	35	42688	9830	29899925
Hydrops foetalis	10.86	10.40	6	42717	264	29909491
Overdose	10.86	10.40	73	42650	84264	29825491
Ascites	10.85	10.40	88	42635	35833	29873922
Bronchopneumopathy	10.82	10.40	7	42716	412	29909343
Cold sweat	10.82	10.40	33	42690	9049	29900706
Post transplant distal limb syndrome	10.66	10.40	6	42717	274	29909481
Mucosal inflammation	10.53	10.40	17	42706	30477	29879278
Ankyloglossia congenital	10.46	10.40	6	42717	284	29909471
Neuropathic arthropathy	10.43	10.40	5	42718	163	29909592

Pharmacologic Action:

Source	Code	Description
ATC	A10AB05	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, fast-acting
ATC	A10AD05	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
ATC	A10AD06	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
FDA CS	M0011417	Insulin
FDA EPC	N0000175453	Insulin Analog
MeSH PA	D007004	Hypoglycemic Agents

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Diabetes mellitus	indication	73211009	DOID:9351

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Insulin receptor	Kinase	P06213	INSR_HUMAN	AGONIST				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D04475	KEGG_DRUG
4021226	VUID
N0000148670	NUI
4021226	VANDF
4021394	VANDF
C0123677	UMLSCUI
CHEMBL1201496	ChEMBL_ID
CHEMBL1201664	ChEMBL_ID
DB01306	DRUGBANK_ID
D061267	MESH_DESCRIPTOR_UI
7541	INN_ID
D933668QVX	UNII
118984445	PUBCHEM_CID
284810	RXNORM
15636	MMSL
17095	MMSL
327602	MMSL
37703	MMSL
d04697	MMSL
d04838	MMSL
007992	NDDF
009607	NDDF
325072002	SNOMEDCT_US
388452006	SNOMEDCT_US
427292001	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	0169-2100	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	29 sections
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	0169-2101	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	29 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	0169-2200	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	27 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	0169-2201	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	27 sections
Fiasp	HUMAN PRESCRIPTION DRUG LABEL	1	0169-3201	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	26 sections
Fiasp	HUMAN PRESCRIPTION DRUG LABEL	1	0169-3204	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	26 sections
Fiasp	HUMAN PRESCRIPTION DRUG LABEL	1	0169-3205	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	26 sections
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	0169-3303	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	29 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	0169-3685	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	27 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	0169-3696	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	27 sections
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	0169-6338	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	29 sections
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	0169-6339	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	29 sections
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	0169-7501	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	29 sections
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1664	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	NDA	29 sections
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1664	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	NDA	29 sections
NovoLog	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1665	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	NDA	29 sections
NOVOLOG	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1678	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	NDA	29 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	50090-2272	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	NDA	29 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	50090-2272	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	NDA	29 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	50090-2273	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	NDA	29 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	50090-2273	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	NDA	29 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4074	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	27 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4085	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	27 sections
Insulin Aspart	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4955	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	28 sections
Insulin Aspart	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4956	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	BLA	28 sections
.Insulin Aspart Protamine and Insulin Aspart	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4959	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	28 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	54868-5201	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	NDA	31 sections
NovoLog Mix 70/30	HUMAN PRESCRIPTION DRUG LABEL	1	54868-5327	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	NDA	31 sections
NovoLog	HUMAN PRESCRIPTION DRUG LABEL	1	64725-0750	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	NDA	28 sections
NovoLog	HUMAN PRESCRIPTION DRUG LABEL	1	68258-8899	INJECTION, SOLUTION	100 [iU]	INTRAVENOUS	NDA	29 sections