insulin aspart 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4981 116094-23-6

Description:

MoleculeDescription

Synonyms:

  • insulin aspart protamine recombinant
  • insulin aspart protamine
  • insulin aspart protamine crystalline
  • insulin aspart
  • insulin aspart recombinant
  • novolog
  • insulin aspart [rDNA origin]
  • novorapid
Insulin that has been modified to contain an ASPARTIC ACID instead of a PROLINE at position 38 of the B-chain.
  • Molecular weight: 5825.60
  • Formula: C256H381N65O79S6
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 2345.16
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
40 U P
40 U P
40 U P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 20, 2019 PMDA Novo Nordisk Pharma Ltd.
Sept. 7, 1999 EMA NovoRapid
June 7, 2000 FDA NOVO NORDISK INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Diabetic ketoacidosis 1392.54 10.81 550 46663 17322 50540589
Hypoglycaemia 1212.60 10.81 704 46509 52877 50505034
Blood glucose increased 1179.81 10.81 767 46446 70557 50487354
Blood glucose decreased 402.46 10.81 236 46977 17975 50539936
Hyperglycaemia 370.89 10.81 292 46921 36113 50521798
Diabetes mellitus inadequate control 318.79 10.81 181 47032 12964 50544947
Ketoacidosis 209.01 10.81 92 47121 3803 50554108
Glycosylated haemoglobin increased 199.54 10.81 124 47089 10482 50547429
Diabetic retinopathy 182.39 10.81 71 47142 2139 50555772
Hypoglycaemic unconsciousness 161.76 10.81 49 47164 673 50557238
Blood glucose fluctuation 160.23 10.81 78 47135 4068 50553843
Acute kidney injury 158.46 10.81 520 46693 227538 50330373
Hypoglycaemic coma 158.00 10.81 65 47148 2268 50555643
Product leakage 153.84 10.81 44 47169 488 50557423
Drug ineffective 138.16 10.81 356 46857 818977 49738934
Diabetic metabolic decompensation 123.73 10.81 48 47165 1432 50556479
Blood glucose abnormal 103.25 10.81 69 47144 6603 50551308
Drug intolerance 102.77 10.81 38 47175 219066 50338845
Arthropathy 93.79 10.81 17 47196 157889 50400022
Synovitis 89.06 10.81 7 47206 123858 50434053
Systemic lupus erythematosus 88.29 10.81 13 47200 140609 50417302
Contraindicated product administered 84.34 10.81 18 47195 148940 50408971
Diabetic neuropathy 83.16 10.81 48 47165 3543 50554368
Product quality issue 83.05 10.81 122 47091 30736 50527175
Joint swelling 82.32 10.81 65 47148 245221 50312690
Treatment failure 81.34 10.81 15 47198 137622 50420289
Alopecia 77.23 10.81 69 47144 244978 50312933
Infusion related reaction 75.22 10.81 32 47181 169525 50388386
Glossodynia 74.15 10.81 10 47203 115559 50442352
Hypoglycaemic seizure 72.76 10.81 24 47189 441 50557470
Exposure during pregnancy 72.54 10.81 263 46950 120752 50437159
Hyper IgE syndrome 70.32 10.81 23 47190 411 50557500
Liquid product physical issue 67.61 10.81 26 47187 757 50557154
Hypoglycaemia unawareness 64.89 10.81 16 47197 94 50557817
Pain 63.73 10.81 301 46912 578602 49979309
Arthralgia 63.00 10.81 205 47008 438497 50119414
Diabetic ketosis 60.49 10.81 17 47196 176 50557735
Rheumatoid arthritis 58.05 10.81 62 47151 202488 50355423
Anti-insulin antibody positive 57.41 10.81 14 47199 78 50557833
Pericarditis 55.03 10.81 5 47208 78684 50479227
Ketosis 54.76 10.81 20 47193 503 50557408
Completed suicide 53.69 10.81 28 47185 131861 50426050
Hypoglycaemia neonatal 50.50 10.81 22 47191 886 50557025
Therapeutic product effect decreased 49.57 10.81 33 47180 136017 50421894
Toxicity to various agents 49.54 10.81 76 47137 212423 50345488
Infective pulmonary exacerbation of cystic fibrosis 49.28 10.81 48 47165 7861 50550050
Abdominal discomfort 49.22 10.81 88 47125 231553 50326358
Hyperkalaemia 49.04 10.81 126 47087 47963 50509948
Wound 48.46 10.81 19 47194 105775 50452136
Restrictive pulmonary disease 46.79 10.81 24 47189 1400 50556511
Drug hypersensitivity 45.95 10.81 104 47109 250906 50307005
Lactic acidosis 45.59 10.81 98 47115 33257 50524654
Discomfort 44.12 10.81 23 47190 108357 50449554
Lipodystrophy acquired 42.52 10.81 22 47191 1307 50556604
Chronic kidney disease 42.42 10.81 106 47107 39665 50518246
Wrong product administered 42.06 10.81 37 47176 5323 50552588
Premature baby 41.60 10.81 67 47146 18270 50539641
Euglycaemic diabetic ketoacidosis 40.86 10.81 28 47185 2791 50555120
Heart sounds 40.79 10.81 17 47196 613 50557298
Diabetes mellitus 40.57 10.81 119 47094 48914 50508997
Foetal exposure during pregnancy 40.43 10.81 83 47130 27276 50530635
Musculoskeletal stiffness 39.45 10.81 37 47176 128444 50429467
Renal failure 39.25 10.81 200 47013 106433 50451478
Prolonged expiration 38.58 10.81 17 47196 704 50557207
Ketonuria 38.37 10.81 15 47198 457 50557454
Myocardial infarction 37.82 10.81 174 47039 88853 50469058
Oesophageal spasm 36.14 10.81 24 47189 2272 50555639
Polycystic ovaries 34.42 10.81 24 47189 2460 50555451
Dehydration 33.93 10.81 251 46962 152198 50405713
Sleep apnoea syndrome 33.62 10.81 71 47142 23797 50534114
Polyuria 33.19 10.81 37 47176 7084 50550827
Helicobacter infection 32.59 10.81 4 47209 49698 50508213
Sinusitis 32.56 10.81 69 47144 170489 50387422
Insulin resistance 32.50 10.81 15 47198 693 50557218
Bladder agenesis 32.45 10.81 10 47203 146 50557765
Cloacal exstrophy 32.01 10.81 10 47203 153 50557758
Genitalia external ambiguous 32.01 10.81 10 47203 153 50557758
Oesophageal pain 31.83 10.81 24 47189 2778 50555133
Congenital ectopic bladder 31.61 10.81 9 47204 98 50557813
Swelling 31.50 10.81 90 47123 200782 50357129
Caudal regression syndrome 31.37 10.81 10 47203 164 50557747
Lethargy 30.92 10.81 109 47104 49323 50508588
Gastrointestinal malformation 30.77 10.81 10 47203 175 50557736
Meconium stain 30.25 10.81 10 47203 185 50557726
Anencephaly 29.34 10.81 10 47203 204 50557707
Gastrointestinal disorder congenital 29.23 10.81 9 47204 131 50557780
Congenital genital malformation 28.56 10.81 9 47204 142 50557769
Tethered cord syndrome 28.42 10.81 10 47203 225 50557686
Product physical issue 28.33 10.81 27 47186 4305 50553606
Pre-eclampsia 27.96 10.81 36 47177 8008 50549903
Hypersensitivity 27.79 10.81 105 47108 215056 50342855
Coronavirus test positive 27.73 10.81 13 47200 623 50557288
Blood ketone body 27.59 10.81 7 47206 47 50557864
Pancreatitis 27.54 10.81 95 47118 42519 50515392
Neural tube defect 26.43 10.81 9 47204 183 50557728
Respiration abnormal 26.38 10.81 28 47185 5074 50552837
Diabetic nephropathy 26.05 10.81 16 47197 1323 50556588
Sepsis neonatal 25.83 10.81 11 47202 419 50557492
Irritable bowel syndrome 25.68 10.81 8 47205 51433 50506478
Diabetic gastroparesis 25.56 10.81 9 47204 203 50557708
Type 1 diabetes mellitus 25.46 10.81 22 47191 3091 50554820
Therapeutic product effect incomplete 25.10 10.81 29 47184 91486 50466425
Fracture blisters 24.36 10.81 7 47206 79 50557832
Dyslipidaemia 24.35 10.81 29 47184 5959 50551952
Accidental underdose 24.29 10.81 12 47201 646 50557265
Anal atresia 23.48 10.81 10 47203 381 50557530
Vomiting 23.24 10.81 578 46635 460180 50097731
International normalised ratio abnormal 23.06 10.81 20 47193 2823 50555088
Cystic fibrosis 22.93 10.81 20 47193 2844 50555067
Device failure 22.86 10.81 27 47186 5501 50552410
Impaired gastric emptying 22.77 10.81 34 47179 8684 50549227
Nasopharyngitis 22.49 10.81 98 47115 192829 50365082
Bicuspid aortic valve 22.36 10.81 7 47206 108 50557803
Cerebrovascular accident 22.26 10.81 158 47055 94522 50463389
Hospitalisation 21.31 10.81 122 47091 67815 50490096
Mobility decreased 21.21 10.81 26 47187 79922 50477989
Diabetic hyperosmolar coma 20.72 10.81 9 47204 360 50557551
Off label use 20.65 10.81 315 46898 474111 50083800
Acute myocardial infarction 20.45 10.81 67 47146 29206 50528705
Hyperhidrosis 20.31 10.81 148 47065 89278 50468633
Caesarean section 20.28 10.81 45 47168 15594 50542317
Neonatal respiratory distress syndrome 20.19 10.81 18 47195 2636 50555275
Meningomyelocele 19.86 10.81 10 47203 561 50557350
Large intestine polyp 19.73 10.81 29 47184 7303 50550608
Flank pain 19.62 10.81 40 47173 13075 50544836
Dialysis 19.41 10.81 33 47180 9405 50548506
Umbilical cord abnormality 19.34 10.81 10 47203 593 50557318
Rash 19.19 10.81 290 46923 437181 50120730
Depressive symptom 19.15 10.81 19 47194 3181 50554730
Gastrointestinal disorder 19.04 10.81 37 47176 94419 50463492
Productive cough 18.79 10.81 98 47115 52596 50505315
Hip arthroplasty 18.65 10.81 3 47210 30426 50527485
Dyspnoea 18.61 10.81 654 46559 546954 50010957
Premature delivery 18.22 10.81 56 47157 23607 50534304
Spina bifida 17.98 10.81 10 47203 687 50557224
Shoulder dystocia 17.93 10.81 3 47210 0 50557911
Hyperglycaemic unconsciousness 17.93 10.81 3 47210 0 50557911
Diabetic ketoacidotic hyperglycaemic coma 17.77 10.81 5 47208 52 50557859
Fear-related avoidance of activities 17.67 10.81 6 47207 121 50557790
Restless legs syndrome 17.61 10.81 43 47170 15854 50542057
Abscess 17.32 10.81 40 47173 14232 50543679
Fatigue 17.26 10.81 516 46697 707085 49850826
Exomphalos 17.25 10.81 9 47204 544 50557367
Congenital anomaly 17.22 10.81 13 47200 1508 50556403
Knee arthroplasty 17.14 10.81 6 47207 35840 50522071
Decreased insulin requirement 17.14 10.81 6 47207 133 50557778
Device operational issue 16.88 10.81 7 47206 249 50557662
Product use issue 16.76 10.81 77 47136 149398 50408513
Hypervolaemia 16.61 10.81 57 47156 25442 50532469
Abdominal pain 16.58 10.81 311 46902 235917 50321994
Blood ketone body increased 16.53 10.81 7 47206 263 50557648
Hepatic enzyme increased 16.48 10.81 69 47144 137311 50420600
Hypoglycaemic encephalopathy 16.33 10.81 7 47206 271 50557640
Maculopathy 16.24 10.81 14 47199 1960 50555951
Impaired healing 16.20 10.81 25 47188 69761 50488150
Appetite disorder 16.19 10.81 24 47189 6090 50551821
Diabetic hepatopathy 15.86 10.81 3 47210 3 50557908
Foetal hypokinesia 15.78 10.81 8 47205 455 50557456
White blood cell count decreased 15.68 10.81 56 47157 116666 50441245
Product container issue 15.68 10.81 12 47201 1420 50556491
Rhabdomyolysis 15.62 10.81 75 47138 38952 50518959
Product dispensing error 15.60 10.81 29 47184 8862 50549049
Product administration error 15.52 10.81 47 47166 19652 50538259
Acute painful neuropathy of rapid glycaemic control 15.40 10.81 3 47210 4 50557907
Pemphigoid 15.38 10.81 23 47190 5884 50552027
Device expulsion 15.27 10.81 4 47209 28818 50529093
Hepatic encephalopathy 15.15 10.81 30 47183 9606 50548305
Lymphoedema 15.07 10.81 29 47184 9093 50548818
Headache 15.04 10.81 359 46854 506176 50051735
Resting tremor 14.96 10.81 9 47204 717 50557194
Sputum increased 14.87 10.81 13 47200 1854 50556057
Extradural haematoma 14.59 10.81 12 47201 1575 50556336
Systemic infection 14.49 10.81 14 47199 2269 50555642
Loss of consciousness 14.47 10.81 155 47058 104198 50453713
Immunosuppressant drug level increased 14.34 10.81 16 47197 3066 50554845
Diabetic foot 14.33 10.81 11 47202 1307 50556604
Blister 14.32 10.81 37 47176 85381 50472530
Left ventricular hypertrophy 14.27 10.81 20 47193 4825 50553086
Cholestasis 14.18 10.81 54 47159 25347 50532564
Carcinoid crisis 14.18 10.81 6 47207 225 50557686
Angina pectoris 14.07 10.81 55 47158 26133 50531778
Intentional overdose 13.93 10.81 103 47110 62401 50495510
High risk pregnancy 13.79 10.81 5 47208 123 50557788
Urinary tract infection 13.73 10.81 289 46924 223731 50334180
Hyperglycaemic hyperosmolar nonketotic syndrome 13.59 10.81 8 47205 612 50557299
Fluid retention 13.37 10.81 87 47126 50562 50507349
Mental status changes 13.31 10.81 68 47145 36204 50521707
Rales 13.27 10.81 29 47184 9949 50547962
Anti-insulin antibody increased 13.13 10.81 4 47209 56 50557855
Splenic thrombosis 13.12 10.81 3 47210 12 50557899
Infection 13.08 10.81 101 47112 172853 50385058
Conjoined twins 13.07 10.81 6 47207 274 50557637
Therapeutic response decreased 12.91 10.81 15 47198 47216 50510695
Ataxia 12.91 10.81 35 47178 13751 50544160
Oedema peripheral 12.87 10.81 213 47000 157748 50400163
Renal hypertension 12.86 10.81 5 47208 150 50557761
Macrosomia 12.82 10.81 4 47209 61 50557850
Incorrect dose administered by device 12.79 10.81 16 47197 3459 50554452
Multiple lentigines syndrome 12.77 10.81 5 47208 153 50557758
Diabetic coma 12.71 10.81 8 47205 691 50557220
Sopor 12.57 10.81 44 47169 19835 50538076
Retinopathy 12.48 10.81 14 47199 2698 50555213
Malaise 12.44 10.81 405 46808 335127 50222784
Foetal macrosomia 12.36 10.81 4 47209 69 50557842
Congenital aortic valve stenosis 12.36 10.81 4 47209 69 50557842
Diabetic retinal oedema 12.20 10.81 6 47207 320 50557591
Bursitis 11.87 10.81 3 47210 22132 50535779
Pancreas transplant 11.84 10.81 3 47210 20 50557891
Pancreatic carcinoma 11.83 10.81 21 47192 6193 50551718
Cardiac septal hypertrophy 11.80 10.81 5 47208 188 50557723
Jaundice neonatal 11.62 10.81 8 47205 803 50557108
Blood ketone body present 11.59 10.81 3 47210 22 50557889
Drug abuse 11.58 10.81 24 47189 59822 50498089
Haemodialysis complication 11.56 10.81 5 47208 198 50557713
Incorrect dose administered 11.49 10.81 81 47132 48333 50509578
Polymorphic light eruption 11.37 10.81 3 47210 24 50557887
Adrenal adenoma 11.34 10.81 8 47205 835 50557076
Glucose-6-phosphate dehydrogenase deficiency 11.30 10.81 5 47208 209 50557702
Hip fracture 11.24 10.81 51 47162 25880 50532031
Hepatocellular injury 11.22 10.81 51 47162 25896 50532015
Selective eating disorder 11.19 10.81 11 47202 1821 50556090
Cellulitis 11.17 10.81 108 47105 70690 50487221
Therapy non-responder 11.16 10.81 19 47194 51003 50506908
Neutrophil count decreased 11.15 10.81 16 47197 46010 50511901
Febrile neutropenia 11.13 10.81 50 47163 97617 50460294
Dermo-hypodermitis 10.96 10.81 5 47208 225 50557686
Intentional product use issue 10.94 10.81 36 47177 76882 50481029
Anogenital warts 10.93 10.81 6 47207 402 50557509
Eczema 10.86 10.81 46 47167 22656 50535255

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 1086.55 10.71 742 41985 47604 29484196
Blood glucose increased 624.31 10.71 582 42145 58402 29473398
Diabetic ketoacidosis 613.12 10.71 346 42381 15727 29516073
Blood glucose decreased 342.99 10.71 215 42512 11854 29519946
Diabetes mellitus inadequate control 257.07 10.71 180 42547 11954 29519846
Hyperglycaemia 237.96 10.71 270 42457 34017 29497783
Hypoglycaemic unconsciousness 205.24 10.71 66 42661 697 29531103
Hypoglycaemic coma 179.37 10.71 79 42648 2084 29529716
Blood glucose fluctuation 174.80 10.71 91 42636 3506 29528294
Appendicolith 132.78 10.71 75 42652 3405 29528395
Ketoacidosis 93.82 10.71 61 42666 3578 29528222
Drug abuse 88.93 10.71 7 42720 79876 29451924
Toxicity to various agents 84.49 10.71 76 42651 173585 29358215
Glycosylated haemoglobin increased 84.34 10.71 85 42642 9341 29522459
Appendicitis 76.42 10.71 78 42649 8701 29523099
Acute kidney injury 70.16 10.71 636 42091 264631 29267169
Diabetic retinopathy 67.88 10.71 37 42690 1565 29530235
Product quality issue 67.23 10.71 98 42629 15797 29516003
Diabetic metabolic decompensation 66.44 10.71 35 42692 1381 29530419
Blood glucose abnormal 65.14 10.71 56 42671 5027 29526773
Hypoglycaemic seizure 64.20 10.71 22 42705 287 29531513
Completed suicide 62.59 10.71 26 42701 90220 29441580
Drug ineffective 55.90 10.71 303 42424 362867 29168933
Product leakage 53.89 10.71 21 42706 402 29531398
Anti-insulin antibody positive 52.90 10.71 17 42710 179 29531621
Ascites 50.21 10.71 141 42586 36478 29495322
Cardiogenic shock 46.13 10.71 92 42635 19098 29512702
Hypoglycaemia neonatal 44.69 10.71 29 42698 1695 29530105
Stress 43.47 10.71 96 42631 21394 29510406
Abdominal distension 42.99 10.71 155 42572 45756 29486044
Device malfunction 39.73 10.71 55 42672 8452 29523348
Hyperkalaemia 38.34 10.71 183 42544 61209 29470591
Wrong product administered 35.39 10.71 38 42689 4493 29527307
Diabetic neuropathy 32.03 10.71 33 42694 3720 29528080
Liquid product physical issue 29.90 10.71 13 42714 332 29531468
Diabetic foot 29.59 10.71 25 42702 2191 29529609
Periodontitis 29.55 10.71 23 42704 1794 29530006
Pulmonary valve stenosis congenital 29.28 10.71 10 42717 129 29531671
Vomiting 28.71 10.71 448 42279 211812 29319988
Chronic kidney disease 27.59 10.71 115 42612 36301 29495499
Insulin resistance 27.35 10.71 14 42713 520 29531280
Hypoglycaemia unawareness 27.33 10.71 9 42718 103 29531697
Diabetic nephropathy 26.59 10.71 22 42705 1873 29529927
Cutaneous amyloidosis 26.30 10.71 7 42720 35 29531765
Infective pulmonary exacerbation of cystic fibrosis 25.71 10.71 38 42689 6198 29525602
Lymphangitis 24.51 10.71 13 42714 520 29531280
Diabetic ketoacidotic hyperglycaemic coma 24.41 10.71 9 42718 147 29531653
Gallbladder neoplasm 23.43 10.71 6 42721 25 29531775
Insulin autoimmune syndrome 23.08 10.71 10 42717 253 29531547
Febrile neutropenia 22.98 10.71 84 42643 112156 29419644
Diabetic macroangiopathy 22.94 10.71 5 42722 8 29531792
Pemphigoid 22.78 10.71 40 42687 7541 29524259
Foetal exposure during pregnancy 22.63 10.71 103 42624 33764 29498036
Cystic fibrosis 22.36 10.71 18 42709 1474 29530326
Hypoglycaemic encephalopathy 22.21 10.71 10 42717 278 29531522
Diabetic complication 21.86 10.71 13 42714 650 29531150
Loss of consciousness 21.75 10.71 182 42545 73874 29457926
Bronchopneumopathy 21.68 10.71 11 42716 401 29531399
Vitreous haemorrhage 21.48 10.71 20 42707 1993 29529807
Diabetes mellitus 20.16 10.71 112 42615 39719 29492081
Congenital bladder anomaly 19.54 10.71 9 42718 264 29531536
Congenital cystic kidney disease 19.16 10.71 10 42717 387 29531413
Product use in unapproved indication 19.13 10.71 63 42664 86812 29444988
Anti-insulin antibody 19.13 10.71 5 42722 23 29531777
Sepsis 18.81 10.71 300 42427 142382 29389418
Genitalia external ambiguous 18.37 10.71 8 42719 205 29531595
Wrong technique in device usage process 18.22 10.71 14 42713 1071 29530729
Therapeutic product effect incomplete 18.12 10.71 18 42709 39287 29492513
Treatment failure 18.11 10.71 16 42711 36923 29494877
Diabetic coma 17.51 10.71 12 42715 768 29531032
Death 17.30 10.71 370 42357 341714 29190086
Infusion related reaction 17.10 10.71 23 42704 43863 29487937
General physical health deterioration 17.01 10.71 225 42502 102632 29429168
Hallucination 16.85 10.71 24 42703 44688 29487112
Pancreatitis 16.77 10.71 96 42631 34418 29497382
Renal aplasia 16.76 10.71 11 42716 655 29531145
Gingival hypertrophy 16.73 10.71 16 42711 1649 29530151
Aggression 16.71 10.71 16 42711 35525 29496275
Toe amputation 16.70 10.71 18 42709 2137 29529663
Adenocarcinoma pancreas 16.67 10.71 14 42713 1217 29530583
Diabetic ketosis 16.56 10.71 6 42721 93 29531707
Osteitis 16.46 10.71 15 42712 1454 29530346
Hepatic cirrhosis 16.36 10.71 52 42675 14392 29517408
Disease progression 16.30 10.71 62 42665 81854 29449946
Incorrect dose administered 16.20 10.71 92 42635 32892 29498908
Impaired gastric emptying 16.09 10.71 21 42706 3049 29528751
Fine motor skill dysfunction 15.76 10.71 15 42712 1536 29530264
Product administration error 15.74 10.71 51 42676 14259 29517541
Product physical issue 15.41 10.71 17 42710 2071 29529729
Diabetic foot infection 15.07 10.71 10 42717 607 29531193
Hyperinsulinaemic hypoglycaemia 14.97 10.71 5 42722 60 29531740
Cardiac output decreased 14.60 10.71 11 42716 817 29530983
Polycythaemia neonatorum 14.55 10.71 3 42724 3 29531797
Ventricular fibrillation 14.42 10.71 53 42674 15780 29516020
Hepatotoxicity 14.36 10.71 4 42723 17863 29513937
Condition aggravated 14.17 10.71 139 42588 146156 29385644
Cold sweat 14.08 10.71 36 42691 8806 29522994
Foetal hypokinesia 14.02 10.71 8 42719 370 29531430
Blood ketone body increased 13.94 10.71 8 42719 374 29531426
Truncus arteriosus persistent 13.89 10.71 4 42723 28 29531772
Skin ulcer 13.88 10.71 59 42668 18781 29513019
Hyponatraemia 13.81 10.71 154 42573 67479 29464321
Dry gangrene 13.77 10.71 8 42719 383 29531417
Herpes zoster reactivation 13.60 10.71 7 42720 263 29531537
Treatment noncompliance 13.53 10.71 70 42657 24157 29507643
Neonatal respiratory depression 13.38 10.71 8 42719 404 29531396
Ketosis 13.19 10.71 8 42719 415 29531385
Product complaint 13.09 10.71 26 42701 5379 29526421
Overdose 13.08 10.71 65 42662 79754 29452046
Nausea 13.05 10.71 526 42201 288729 29243071
Trisomy 18 12.60 10.71 6 42721 190 29531610
Spermatic cord disorder 12.48 10.71 3 42724 9 29531791
Pneumobilia 12.37 10.71 4 42723 43 29531757
Heart disease congenital 12.29 10.71 12 42715 1268 29530532
Drug resistance 12.26 10.71 8 42719 21532 29510268
Postprandial hypoglycaemia 12.24 10.71 3 42724 10 29531790
Anxiety 12.08 10.71 73 42654 85292 29446508
Hyperhidrosis 11.86 10.71 144 42583 64396 29467404
Basophil count abnormal 11.81 10.71 3 42724 12 29531788
Hunger 11.76 10.71 12 42715 1337 29530463
Abdominal pain 11.76 10.71 267 42460 135090 29396710
Product label issue 11.72 10.71 6 42721 223 29531577
Hepatocellular carcinoma 11.57 10.71 29 42698 7009 29524791
Insulin-requiring type 2 diabetes mellitus 11.56 10.71 5 42722 126 29531674
Cellulitis 11.56 10.71 109 42618 45731 29486069
Neutrophil count decreased 11.48 10.71 29 42698 43538 29488262
Hydrops foetalis 11.45 10.71 6 42721 234 29531566
Funguria 11.41 10.71 4 42723 56 29531744
Pancreatic carcinoma 11.27 10.71 29 42698 7121 29524679
Gangrene 11.08 10.71 21 42706 4197 29527603
Mucosal inflammation 10.91 10.71 18 42709 31577 29500223
Device failure 10.89 10.71 14 42713 2002 29529798
Peritonitis bacterial 10.84 10.71 25 42702 5731 29526069
Euglycaemic diabetic ketoacidosis 10.80 10.71 16 42711 2614 29529186
Haemolytic anaemia 10.75 10.71 34 42693 9385 29522415

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 2061.27 9.91 1291 74144 88601 64334696
Diabetic ketoacidosis 1678.67 9.91 779 74656 29066 64394231
Blood glucose increased 1395.45 9.91 1050 74385 97023 64326274
Blood glucose decreased 623.14 9.91 369 75066 22754 64400543
Hyperglycaemia 552.21 9.91 503 74932 60465 64362832
Diabetes mellitus inadequate control 499.28 9.91 311 75124 21010 64402287
Hypoglycaemic unconsciousness 321.85 9.91 97 75338 1024 64422273
Hypoglycaemic coma 321.70 9.91 137 75298 4137 64419160
Blood glucose fluctuation 263.41 9.91 132 75303 5823 64417474
Ketoacidosis 262.68 9.91 138 75297 6725 64416572
Acute kidney injury 219.13 9.91 1071 74364 448169 63975128
Diabetic retinopathy 213.65 9.91 91 75344 2748 64420549
Glycosylated haemoglobin increased 212.84 9.91 165 75270 15854 64407443
Product leakage 184.88 9.91 56 75379 602 64422695
Diabetic metabolic decompensation 177.76 9.91 79 75356 2649 64420648
Product quality issue 158.81 9.91 185 75250 29614 64393683
Appendicolith 147.87 9.91 75 75360 3394 64419903
Drug ineffective 143.71 9.91 504 74931 839743 63583554
Completed suicide 129.86 9.91 50 75385 224364 64198933
Toxicity to various agents 129.07 9.91 141 75294 363372 64059925
Blood glucose abnormal 123.19 9.91 94 75341 8819 64414478
Hypoglycaemic seizure 112.76 9.91 40 75395 728 64422569
Anti-insulin antibody positive 96.21 9.91 28 75407 259 64423038
Hypoglycaemia unawareness 90.15 9.91 24 75411 154 64423143
Drug intolerance 84.75 9.91 58 75377 187934 64235363
Synovitis 83.97 9.91 9 75426 99081 64324216
Diabetic neuropathy 83.92 9.91 62 75373 5539 64417758
Infusion related reaction 82.13 9.91 45 75390 164422 64258875
Liquid product physical issue 80.39 9.91 32 75403 810 64422487
Arthropathy 78.63 9.91 22 75413 120945 64302352
Drug abuse 77.35 9.91 29 75406 132345 64290952
Hyperkalaemia 77.17 9.91 277 75158 100852 64322445
Infective pulmonary exacerbation of cystic fibrosis 72.68 9.91 79 75356 11717 64411580
Appendicitis 71.88 9.91 84 75351 13485 64409812
Joint swelling 71.53 9.91 88 75347 215294 64208003
Diabetic ketosis 65.28 9.91 22 75413 341 64422956
Treatment failure 62.75 9.91 29 75406 116787 64306510
Wrong product administered 62.68 9.91 60 75375 7660 64415637
Hyper IgE syndrome 62.27 9.91 23 75412 472 64422825
Hand deformity 60.86 9.91 3 75432 62768 64360529
Arthralgia 59.79 9.91 290 75145 441970 63981327
Pain 59.66 9.91 391 75044 553120 63870177
Exposure during pregnancy 57.75 9.91 211 75224 77464 64345833
Ketosis 57.01 9.91 26 75409 927 64422370
Rheumatoid arthritis 56.81 9.91 65 75370 164229 64259068
Systemic lupus erythematosus 56.60 9.91 11 75424 77601 64345696
Alopecia 55.73 9.91 67 75368 165623 64257674
Chronic kidney disease 55.16 9.91 171 75264 57748 64365549
Contraindicated product administered 53.09 9.91 30 75405 107799 64315498
Diabetic nephropathy 50.50 9.91 34 75401 2620 64420677
Insulin resistance 50.46 9.91 25 75410 1075 64422222
Glossodynia 47.53 9.91 9 75426 64687 64358610
Vomiting 46.46 9.91 903 74532 550214 63873083
Euglycaemic diabetic ketoacidosis 45.74 9.91 43 75392 5367 64417930
Drug hypersensitivity 44.26 9.91 137 75298 237678 64185619
Sinusitis 43.97 9.91 64 75371 145864 64277433
Therapeutic product effect decreased 43.96 9.91 42 75393 115309 64307988
Product physical issue 42.52 9.91 34 75401 3415 64419882
Diabetic ketoacidotic hyperglycaemic coma 41.90 9.91 14 75421 211 64423086
Abdominal distension 40.35 9.91 220 75215 95774 64327523
Pemphigoid 39.02 9.91 61 75374 12925 64410372
Device malfunction 38.66 9.91 72 75363 17561 64405736
Cystic fibrosis 38.43 9.91 32 75403 3402 64419895
Oesophageal spasm 37.94 9.91 28 75407 2497 64420800
Therapeutic product effect incomplete 37.91 9.91 39 75396 103443 64319854
Diabetic foot 37.85 9.91 30 75405 2975 64420322
Pancreatitis 37.81 9.91 154 75281 59453 64363844
Diabetes mellitus 37.72 9.91 166 75269 66308 64356989
Cardiogenic shock 35.88 9.91 101 75334 32326 64390971
Heart sounds 34.66 9.91 16 75419 587 64422710
Lactic acidosis 34.57 9.91 153 75282 61257 64362040
Ascites 34.55 9.91 154 75281 61847 64361450
Hypoglycaemic encephalopathy 34.43 9.91 16 75419 596 64422701
Abdominal discomfort 33.93 9.91 105 75330 182217 64241080
Hyperhidrosis 33.77 9.91 256 75179 124664 64298633
Product administration error 33.48 9.91 89 75346 27554 64395743
Ketonuria 33.18 9.91 19 75416 1098 64422199
Nasopharyngitis 33.00 9.91 118 75317 195955 64227342
Pericarditis 32.83 9.91 16 75419 62500 64360797
Abdominal pain 32.71 9.91 530 74905 311845 64111452
Polycystic ovaries 32.61 9.91 24 75411 2131 64421166
Restrictive pulmonary disease 32.44 9.91 24 75411 2148 64421149
Insulin autoimmune syndrome 32.05 9.91 13 75422 346 64422951
Loss of consciousness 32.04 9.91 289 75146 148076 64275221
Cutaneous amyloidosis 31.57 9.91 8 75427 41 64423256
Helicobacter infection 31.21 9.91 4 75431 38358 64384939
Blood ketone body increased 30.90 9.91 15 75420 617 64422680
Dehydration 30.33 9.91 387 75048 216376 64206921
Prolonged expiration 29.94 9.91 16 75419 807 64422490
Oesophageal pain 29.65 9.91 27 75408 3236 64420061
Vitreous haemorrhage 28.96 9.91 26 75409 3059 64420238
Dyslipidaemia 28.58 9.91 44 75391 9198 64414099
Musculoskeletal stiffness 28.20 9.91 64 75371 123142 64300155
Irritable bowel syndrome 27.88 9.91 5 75430 37364 64385933
Febrile neutropenia 27.09 9.91 120 75315 187537 64235760
Headache 27.08 9.91 446 74989 529021 63894276
Stress 26.28 9.91 140 75295 60394 64362903
Incorrect dose administered 26.02 9.91 140 75295 60625 64362672
Lethargy 25.70 9.91 159 75276 72435 64350862
Pre-eclampsia 25.66 9.91 34 75401 6197 64417100
Impaired gastric emptying 24.59 9.91 40 75395 8764 64414533
Product use in unapproved indication 24.27 9.91 115 75320 176503 64246794
Off label use 24.16 9.91 560 74875 632246 63791051
Blood ketone body 23.33 9.91 8 75427 131 64423166
Cold sweat 23.07 9.91 56 75379 16399 64406898
Fracture blisters 22.80 9.91 7 75428 79 64423218
Device operational issue 22.31 9.91 10 75425 342 64422955
Neutrophil count decreased 22.14 9.91 35 75400 77161 64346136
Discomfort 21.96 9.91 38 75397 80840 64342457
Hepatocellular carcinoma 21.88 9.91 37 75398 8366 64414931
Mobility decreased 21.82 9.91 42 75393 85798 64337499
Type 1 diabetes mellitus 21.77 9.91 30 75405 5675 64417622
Sepsis 21.60 9.91 384 75051 229957 64193340
Renal failure 21.57 9.91 315 75120 181373 64241924
Intentional product use issue 21.44 9.91 50 75385 95314 64327983
Treatment noncompliance 21.28 9.91 104 75331 43378 64379919
Muscle injury 20.93 9.91 3 75432 26434 64396863
Diabetic hepatopathy 20.77 9.91 4 75431 3 64423294
Lymphangitis 20.74 9.91 15 75420 1296 64422001
Folliculitis 20.43 9.91 5 75430 30072 64393225
Dyspnoea 20.36 9.91 1031 74404 717643 63705654
Device failure 20.34 9.91 29 75406 5663 64417634
Foetal macrosomia 20.24 9.91 4 75431 4 64423293
Gastrointestinal disorder 20.20 9.91 47 75388 89662 64333635
Bronchopneumopathy 20.10 9.91 11 75424 582 64422715
Coronavirus test positive 20.08 9.91 13 75422 938 64422359
Drug resistance 19.98 9.91 8 75427 35094 64388203
Hospitalisation 19.68 9.91 153 75282 75054 64348243
Respiration abnormal 19.44 9.91 30 75405 6285 64417012
C-reactive protein abnormal 19.40 9.91 5 75430 29042 64394255
Gallbladder neoplasm 19.29 9.91 6 75429 71 64423226
Decreased insulin requirement 18.94 9.91 7 75428 144 64423153
Polyuria 18.77 9.91 44 75391 12599 64410698
Blood pressure fluctuation 18.48 9.91 20 75415 51851 64371446
Cellulitis 18.48 9.91 179 75256 93478 64329819
Hepatotoxicity 18.43 9.91 12 75423 39950 64383347
Sleep apnoea syndrome 18.07 9.91 76 75359 29756 64393541
Hepatic encephalopathy 18.05 9.91 60 75375 21006 64402291
Adenocarcinoma pancreas 18.01 9.91 16 75419 1857 64421440
Myocardial infarction 17.94 9.91 283 75152 165538 64257759
Fear-related avoidance of activities 17.92 9.91 6 75429 91 64423206
Product container issue 17.89 9.91 12 75423 919 64422378
Swelling 17.78 9.91 112 75323 160106 64263191
Periodontitis 17.60 9.91 23 75412 4136 64419161
Hyperglycaemic unconsciousness 17.26 9.91 3 75432 0 64423297
Wrong technique in device usage process 17.23 9.91 19 75416 2863 64420434
Fluid retention 17.14 9.91 124 75311 59482 64363815
Hypervolaemia 16.93 9.91 89 75346 38196 64385101
Sputum increased 16.80 9.91 21 75414 3614 64419683
C-reactive protein increased 16.71 9.91 56 75379 94853 64328444
Foetal hypokinesia 16.66 9.91 8 75427 321 64422976
Anti-insulin antibody increased 16.62 9.91 6 75429 115 64423182
Lower respiratory tract infection 16.54 9.91 56 75379 94558 64328739
Hypothermia 16.52 9.91 56 75379 19800 64403497
Wound 16.48 9.91 41 75394 76436 64346861
Haemorrhagic stroke 16.29 9.91 36 75399 9915 64413382
Blood insulin increased 16.17 9.91 8 75427 343 64422954
Gangrene 16.13 9.91 30 75405 7308 64415989
Hyperinsulinaemic hypoglycaemia 15.94 9.91 6 75429 130 64423167
Pancreatitis acute 15.88 9.91 95 75340 42760 64380537
Blood ketone body present 15.86 9.91 5 75430 62 64423235
Diabetic hyperosmolar coma 15.64 9.91 10 75425 706 64422591
Hip arthroplasty 15.62 9.91 3 75432 21348 64401949
Diabetic macroangiopathy 15.49 9.91 6 75429 141 64423156
Systemic infection 15.42 9.91 22 75413 4299 64418998
Diabetic gastroparesis 15.36 9.91 7 75428 249 64423048
Insulin-requiring type 2 diabetes mellitus 15.33 9.91 6 75429 145 64423152
Anti-insulin antibody 15.30 9.91 5 75430 70 64423227
Hyperglycaemic hyperosmolar nonketotic syndrome 15.18 9.91 14 75421 1705 64421592
Hyperglycaemic seizure 15.18 9.91 3 75432 3 64423294
Arthritis 15.06 9.91 49 75386 83765 64339532
Product dispensing error 15.03 9.91 38 75397 11412 64411885
Increased insulin requirement 14.92 9.91 6 75429 156 64423141
Acute painful neuropathy of rapid glycaemic control 14.72 9.91 3 75432 4 64423293
Hypersensitivity 14.59 9.91 153 75282 196299 64226998
Gingival hypertrophy 14.54 9.91 17 75418 2730 64420567
Oedema peripheral 14.51 9.91 335 75100 209982 64213315
Injection site reaction 14.51 9.91 20 75415 46644 64376653
Dry gangrene 14.32 9.91 10 75425 818 64422479
Respiratory arrest 14.28 9.91 25 75410 52960 64370337
Product prescribing error 14.25 9.91 80 75355 35189 64388108
Disease progression 14.24 9.91 102 75333 141578 64281719
Premature delivery 14.23 9.91 51 75384 18538 64404759
Cerebrovascular accident 14.20 9.91 233 75202 137350 64285947
Poisoning 14.17 9.91 4 75431 21875 64401422
Blood cholesterol increased 14.07 9.91 23 75412 50043 64373254
Fine motor skill dysfunction 14.01 9.91 22 75413 4677 64418620
Loss of personal independence in daily activities 13.99 9.91 41 75394 72413 64350884
Product complaint 13.98 9.91 38 75397 11916 64411381
Heart rate decreased 13.94 9.91 27 75408 55040 64368257
White blood cell count decreased 13.82 9.91 118 75317 157719 64265578
Glucose-6-phosphate dehydrogenase deficiency 13.65 9.91 7 75428 324 64422973
Diabetic coma 13.62 9.91 11 75424 1120 64422177
Red blood cell sedimentation rate increased 13.58 9.91 10 75425 31225 64392072
Dialysis 13.45 9.91 47 75388 16873 64406424
Product odour abnormal 13.44 9.91 11 75424 1142 64422155
Device expulsion 13.44 9.91 4 75431 21132 64402165
Diabetic retinal oedema 13.34 9.91 7 75428 340 64422957
Malaise 13.21 9.91 578 74857 395669 64027628
Nonreassuring foetal heart rate pattern 13.11 9.91 3 75432 9 64423288
Angina pectoris 13.09 9.91 94 75341 44987 64378310
Retrograde ejaculation 13.05 9.91 6 75429 218 64423079
International normalised ratio abnormal 13.04 9.91 22 75413 4966 64418331
End stage renal disease 12.96 9.91 34 75401 10441 64412856
Therapy non-responder 12.93 9.91 37 75398 65862 64357435
Peritonitis bacterial 12.92 9.91 31 75404 9012 64414285
Cardiac failure 12.86 9.91 222 75213 132151 64291146
Adverse drug reaction 12.67 9.91 21 75414 45443 64377854
Sedation 12.66 9.91 18 75417 41444 64381853
Myelosuppression 12.66 9.91 6 75429 23824 64399473
Erythema 12.58 9.91 149 75286 186921 64236376
Infection 12.53 9.91 147 75288 184733 64238564
Hepatocellular injury 12.38 9.91 93 75342 45142 64378155
Hepatic enzyme increased 12.36 9.91 95 75340 129848 64293449
Intentional overdose 12.31 9.91 160 75275 89784 64333513
Large intestine polyp 12.23 9.91 34 75401 10803 64412494
Dialysis device insertion 12.05 9.91 4 75431 59 64423238
Swollen tongue 12.02 9.91 76 75359 34878 64388419
Fall 11.96 9.91 599 74836 416227 64007070
Acetonaemia 11.92 9.91 6 75429 267 64423030
Heart rate irregular 11.63 9.91 9 75426 27404 64395893
Mental status changes 11.62 9.91 116 75319 61046 64362251
Bone pain 11.47 9.91 24 75411 47548 64375749
Accidental underdose 11.46 9.91 8 75427 654 64422643
Hot flush 11.42 9.91 23 75412 46212 64377085
Appetite disorder 11.29 9.91 24 75411 6437 64416860
Acute myocardial infarction 11.28 9.91 128 75307 69590 64353707
Flank pain 11.21 9.91 43 75392 16146 64407151
Oral herpes 11.13 9.91 6 75429 22146 64401151
Lymphoedema 11.10 9.91 31 75404 9874 64413423
Foot amputation 11.05 9.91 8 75427 693 64422604
Cystic fibrosis related diabetes 11.02 9.91 5 75430 176 64423121
Conjunctivitis 11.01 9.91 5 75430 20349 64402948
Hypokalaemia 10.98 9.91 202 75233 121701 64301596
Condition aggravated 10.92 9.91 342 75093 372084 64051213
Ventricular fibrillation 10.92 9.91 56 75379 23804 64399493
Renal impairment 10.89 9.91 220 75215 134797 64288500
Neutropenia 10.88 9.91 206 75229 239418 64183879
Postprandial hypoglycaemia 10.88 9.91 4 75431 81 64423216
Maculopathy 10.87 9.91 14 75421 2482 64420815
Hepatic cirrhosis 10.86 9.91 60 75375 26238 64397059
Diabetic foot infection 10.83 9.91 8 75427 714 64422583
Subdural haemorrhage 10.82 9.91 21 75414 5282 64418015
Rash 10.73 9.91 433 75002 458116 63965181
High risk pregnancy 10.70 9.91 4 75431 85 64423212
Drug delivery system issue 10.69 9.91 3 75432 24 64423273
Depressive symptom 10.67 9.91 19 75416 4477 64418820
Progressive multifocal leukoencephalopathy 10.63 9.91 4 75431 18228 64405069
Incorrect dose administered by device 10.62 9.91 18 75417 4079 64419218
Multiple lentigines syndrome 10.55 9.91 5 75430 195 64423102
Basophil count abnormal 10.48 9.91 3 75432 26 64423271
Polymorphic light eruption 10.48 9.91 3 75432 26 64423271
Acute myeloid leukaemia 10.45 9.91 10 75425 27453 64395844
Glomerular filtration rate decreased 10.44 9.91 48 75387 19524 64403773
Impaired healing 10.42 9.91 36 75399 60437 64362860
Renal artery stenosis 10.42 9.91 15 75420 2954 64420343
Necrotising soft tissue infection 10.36 9.91 5 75430 203 64423094
Immunodeficiency 10.35 9.91 3 75432 16121 64407176
Eye haemorrhage 10.21 9.91 27 75408 8333 64414964
Multiple organ dysfunction syndrome 10.19 9.91 171 75264 101242 64322055
Threatened labour 10.18 9.91 7 75428 558 64422739
Leg amputation 10.16 9.91 16 75419 3411 64419886
Body mass index abnormal 10.11 9.91 5 75430 214 64423083
Rhabdomyolysis 10.08 9.91 157 75278 91569 64331728
Dyspepsia 10.05 9.91 54 75381 80258 64343039
Ill-defined disorder 9.98 9.91 23 75412 44029 64379268
Disseminated intravascular coagulation 9.92 9.91 14 75421 32334 64390963

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10AB05 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
INSULINS AND ANALOGUES
Insulins and analogues for injection, fast-acting
ATC A10AD05 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
INSULINS AND ANALOGUES
Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
ATC A10AD06 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
INSULINS AND ANALOGUES
Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
FDA CS M0011417 Insulin
FDA EPC N0000175453 Insulin Analog
CHEBI has role CHEBI:35526 antidiabetic
FDA EPC N0000175944 Insulin
MeSH PA D007004 Hypoglycemic Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus indication 73211009 DOID:9351




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Insulin receptor Kinase AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
D04475 KEGG_DRUG
4021226 VUID
N0000148670 NUI
4017559 VANDF
4017569 VANDF
4019786 VANDF
4021226 VANDF
4021394 VANDF
CHEBI:5931 CHEBI
CHEMBL1201496 ChEMBL_ID
CHEMBL1201664 ChEMBL_ID
7541 INN_ID
DB01306 DRUGBANK_ID
D933668QVX UNII
118984445 PUBCHEM_CID
118984375 PUBCHEM_CID
DB00030 DRUGBANK_ID
253182 RXNORM
15636 MMSL
17095 MMSL
327602 MMSL
37703 MMSL
4885 MMSL
4886 MMSL
d00262 MMSL
d04369 MMSL
d04697 MMSL
d04838 MMSL
126210001 SNOMEDCT_US
325072002 SNOMEDCT_US
388452006 SNOMEDCT_US
417423002 SNOMEDCT_US
420609005 SNOMEDCT_US
427292001 SNOMEDCT_US
96367001 SNOMEDCT_US
D061267 MESH_DESCRIPTOR_UI
C0123677 UMLSCUI
C0795635 UMLSCUI
5186 INN_ID
000869 NDDF
000870 NDDF
006518 NDDF
007992 NDDF
009607 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 0169-2100 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 29 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 0169-2101 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 29 sections
NovoLog Mix 70/30 HUMAN PRESCRIPTION DRUG LABEL 1 0169-2200 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 27 sections
NovoLog Mix 70/30 HUMAN PRESCRIPTION DRUG LABEL 1 0169-2201 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 27 sections
Fiasp HUMAN PRESCRIPTION DRUG LABEL 1 0169-3201 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 26 sections
Fiasp HUMAN PRESCRIPTION DRUG LABEL 1 0169-3201 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 26 sections
Fiasp HUMAN PRESCRIPTION DRUG LABEL 1 0169-3204 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 26 sections
Fiasp HUMAN PRESCRIPTION DRUG LABEL 1 0169-3204 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 26 sections
Fiasp HUMAN PRESCRIPTION DRUG LABEL 1 0169-3205 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 26 sections
Fiasp HUMAN PRESCRIPTION DRUG LABEL 1 0169-3205 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 26 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 0169-3303 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 29 sections
NovoLog Mix 70/30 HUMAN PRESCRIPTION DRUG LABEL 1 0169-3685 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 27 sections
NovoLog Mix 70/30 HUMAN PRESCRIPTION DRUG LABEL 1 0169-3696 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 27 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 0169-6338 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 29 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 0169-6339 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 29 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 0169-7501 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 29 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 50090-1664 INJECTION, SOLUTION 100 [iU] INTRAVENOUS NDA 29 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 50090-1664 INJECTION, SOLUTION 100 [iU] INTRAVENOUS NDA 29 sections
NovoLog HUMAN PRESCRIPTION DRUG LABEL 1 50090-1665 INJECTION, SOLUTION 100 [iU] INTRAVENOUS NDA 29 sections
NovoLog HUMAN PRESCRIPTION DRUG LABEL 1 50090-1665 INJECTION, SOLUTION 100 [iU] INTRAVENOUS NDA 29 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 50090-1678 INJECTION, SOLUTION 100 [iU] INTRAVENOUS NDA 29 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 50090-1678 INJECTION, SOLUTION 100 [iU] INTRAVENOUS NDA 29 sections
NovoLog Mix 70/30 HUMAN PRESCRIPTION DRUG LABEL 1 50090-2272 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS NDA 29 sections
NovoLog Mix 70/30 HUMAN PRESCRIPTION DRUG LABEL 1 50090-2272 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS NDA 29 sections
NovoLog Mix 70/30 HUMAN PRESCRIPTION DRUG LABEL 1 50090-2273 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS NDA 29 sections
NovoLog Mix 70/30 HUMAN PRESCRIPTION DRUG LABEL 1 50090-2273 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS NDA 29 sections
NovoLog Mix 70/30 HUMAN PRESCRIPTION DRUG LABEL 1 50090-4074 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 27 sections
NovoLog Mix 70/30 HUMAN PRESCRIPTION DRUG LABEL 1 50090-4085 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 27 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 50090-4500 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 28 sections
Insulin Aspart HUMAN PRESCRIPTION DRUG LABEL 1 50090-4955 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 28 sections