insulin aspart 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4981 116094-23-6

Description:

MoleculeDescription

Synonyms:

  • insulin aspart protamine recombinant
  • insulin aspart protamine
  • insulin aspart protamine crystalline
  • insulin aspart
  • insulin aspart recombinant
  • novolog
  • insulin aspart [rDNA origin]
  • novorapid
Insulin that has been modified to contain an ASPARTIC ACID instead of a PROLINE at position 38 of the B-chain.
  • Molecular weight: 5825.60
  • Formula: C256H381N65O79S6
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 2345.16
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
40 U P
40 U P
40 U P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Sept. 20, 2019 PMDA Novo Nordisk Pharma Ltd.
Sept. 7, 1999 EMA NovoRapid
June 7, 2000 FDA NOVO NORDISK INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Diabetic ketoacidosis 1917.50 10.85 703 63988 23704 90540052
Hypoglycaemia 1768.10 10.85 903 63788 68945 90494811
Blood glucose increased 1602.87 10.85 940 63751 94306 90469450
Hyperglycaemia 558.24 10.85 384 64307 50586 90513170
Blood glucose decreased 557.55 10.85 291 64400 23138 90540618
Diabetes mellitus inadequate control 502.38 10.85 252 64439 18432 90545324
Acute kidney injury 338.63 10.85 722 63969 319665 90244091
Ketoacidosis 278.88 10.85 116 64575 5479 90558277
Hypoglycaemic coma 275.41 10.85 97 64594 2893 90560863
Diabetic retinopathy 265.57 10.85 92 64599 2610 90561146
Glycosylated haemoglobin increased 249.10 10.85 149 64542 15413 90548343
Blood glucose fluctuation 245.34 10.85 103 64588 4980 90558776
Hypoglycaemic unconsciousness 218.85 10.85 60 64631 754 90563002
Synovitis 194.19 10.85 10 64681 329742 90234014
Glossodynia 185.63 10.85 11 64680 321768 90241988
Product leakage 182.31 10.85 59 64632 1349 90562407
Lactic acidosis 179.07 10.85 200 64491 50263 90513493
Diabetic metabolic decompensation 178.39 10.85 63 64628 1894 90561862
Blood glucose abnormal 176.03 10.85 100 64591 9392 90554364
Arthropathy 175.85 10.85 26 64665 366216 90197540
Systemic lupus erythematosus 173.04 10.85 26 64665 361870 90201886
Infusion related reaction 166.12 10.85 46 64645 416734 90147022
Pericarditis 156.52 10.85 9 64682 270142 90293614
Treatment failure 147.21 10.85 21 64670 303907 90259849
Human rhinovirus test positive 142.49 10.85 44 64647 859 90562897
Alopecia 142.20 10.85 89 64602 494982 90068774
Respiratory syncytial virus test positive 139.71 10.85 45 64646 1013 90562743
Contraindicated product administered 137.91 10.85 30 64661 320109 90243647
Wound 137.61 10.85 25 64666 302955 90260801
Drug intolerance 136.26 10.85 75 64616 447516 90116240
Joint swelling 135.79 10.85 97 64594 503203 90060553
Helicobacter infection 130.05 10.85 8 64683 226842 90336914
Diabetic neuropathy 112.17 10.85 58 64633 4516 90559240
Irritable bowel syndrome 111.27 10.85 10 64681 207438 90356318
Viral test positive 104.29 10.85 32 64659 611 90563145
Discomfort 102.50 10.85 34 64657 274301 90289455
Therapeutic product effect decreased 100.94 10.85 36 64655 277535 90286221
Hypoglycaemia unawareness 99.09 10.85 22 64669 104 90563652
Dehydration 97.51 10.85 333 64358 194114 90369642
Abdominal discomfort 93.79 10.85 122 64569 477206 90086550
Rheumatoid arthritis 93.71 10.85 73 64618 362541 90201215
Pneumonia haemophilus 91.56 10.85 36 64655 1467 90562289
Impaired healing 91.10 10.85 27 64664 234172 90329584
Anti-insulin antibody positive 90.17 10.85 20 64671 94 90563662
Hyper IgE syndrome 89.90 10.85 27 64664 478 90563278
Hepatic enzyme increased 87.79 10.85 77 64614 360659 90203097
Liquid product physical issue 87.01 10.85 35 64656 1515 90562241
Drug ineffective 86.48 10.85 607 64084 1383691 89180065
Myocardial infarction 85.39 10.85 215 64476 105757 90457999
Hypoglycaemic seizure 82.96 10.85 26 64665 534 90563222
Hyperkalaemia 82.16 10.85 158 64533 64806 90498950
Pain 81.18 10.85 401 64290 995940 89567816
Bursitis 80.71 10.85 3 64688 131651 90432105
Foetal exposure during pregnancy 79.95 10.85 124 64567 42851 90520905
Musculoskeletal stiffness 77.48 10.85 59 64632 296473 90267283
Arthralgia 77.00 10.85 291 64400 778231 89785525
Tongue biting 76.26 10.85 35 64656 2098 90561658
Diabetic ketosis 74.64 10.85 24 64667 537 90563219
Mast cell activation syndrome 72.60 10.85 31 64660 1563 90562193
Oesophageal spasm 72.16 10.85 39 64652 3322 90560434
Heart sounds 71.80 10.85 28 64663 1116 90562640
Psoriatic arthropathy 71.25 10.85 37 64654 228298 90335458
Mouth haemorrhage 70.13 10.85 54 64637 8447 90555309
Ketosis 69.78 10.85 25 64666 784 90562972
Prolonged expiration 69.24 10.85 28 64663 1229 90562527
Blister 66.27 10.85 51 64640 254947 90308809
Renal failure 65.32 10.85 224 64467 130783 90432973
Swelling 65.29 10.85 125 64566 418933 90144823
Hypoglycaemia neonatal 65.29 10.85 26 64665 1096 90562660
Hypersensitivity 64.60 10.85 143 64548 454534 90109222
Blood cholesterol increased 64.46 10.85 34 64657 207978 90355778
Joint range of motion decreased 64.18 10.85 10 64681 135633 90428123
Mobility decreased 62.83 10.85 52 64639 250682 90313074
Sleep apnoea syndrome 62.43 10.85 94 64597 31653 90532103
Insulin resistance 61.06 10.85 25 64666 1133 90562623
Liver injury 60.50 10.85 23 64668 170544 90393212
Oesophageal pain 60.10 10.85 38 64653 4336 90559420
Lip dry 59.56 10.85 3 64688 100952 90462804
Euglycaemic diabetic ketoacidosis 59.20 10.85 43 64648 6158 90557598
Ill-defined disorder 59.11 10.85 29 64662 184862 90378894
Restrictive pulmonary disease 58.06 10.85 30 64661 2332 90561424
Gastrointestinal disorder 57.49 10.85 59 64632 256628 90307128
Chronic kidney disease 57.35 10.85 117 64574 50074 90513682
Sinusitis 57.31 10.85 98 64593 342990 90220766
Infective pulmonary exacerbation of cystic fibrosis 57.18 10.85 52 64639 10227 90553529
Diabetes mellitus 56.89 10.85 136 64555 64739 90499017
Product physical issue 55.75 10.85 40 64651 5620 90558136
Grip strength decreased 53.84 10.85 3 64688 92573 90471183
Wrong product administered 53.21 10.85 44 64647 7621 90556135
Exposure during pregnancy 53.06 10.85 321 64370 238089 90325667
Product use issue 52.61 10.85 97 64594 329822 90233934
Polyuria 52.38 10.85 49 64642 9991 90553765
Lipodystrophy acquired 51.50 10.85 24 64667 1490 90562266
Product quality issue 50.89 10.85 148 64543 79177 90484579
Device failure 50.84 10.85 41 64650 6856 90556900
Hyperhidrosis 49.73 10.85 211 64480 136094 90427662
Premature baby 48.95 10.85 74 64617 25003 90538753
Therapeutic product effect incomplete 48.83 10.85 40 64651 193856 90369900
Ketonuria 48.61 10.85 19 64672 762 90562994
Night sweats 47.99 10.85 16 64675 128750 90435006
Drug hypersensitivity 47.89 10.85 170 64521 463439 90100317
Nasopharyngitis 47.80 10.85 141 64550 406963 90156793
Lethargy 46.62 10.85 124 64567 63015 90500741
Pulmonary fibrosis 46.39 10.85 10 64681 107493 90456263
Stomatitis 46.29 10.85 78 64613 274620 90289136
Premature delivery 46.24 10.85 92 64599 38670 90525086
Respiration abnormal 45.71 10.85 41 64650 7922 90555834
Cerebrovascular accident 45.66 10.85 192 64499 123341 90440415
Conjoined twins 44.29 10.85 16 64675 514 90563242
Urinary tract infection 43.80 10.85 370 64321 305262 90258494
Diabetic nephropathy 42.55 10.85 22 64669 1712 90562044
Peripheral venous disease 42.51 10.85 5 64686 83916 90479840
Caesarean section 42.35 10.85 59 64632 18518 90545238
Dialysis 42.07 10.85 46 64645 11283 90552473
Hydrops foetalis 42.03 10.85 16 64675 597 90563159
Hypercholesterolaemia 40.38 10.85 11 64680 100881 90462875
Hip arthroplasty 39.98 10.85 4 64687 76204 90487552
International normalised ratio abnormal 39.78 10.85 28 64663 3817 90559939
Inflammation 38.90 10.85 42 64649 178550 90385206
Lower respiratory tract infection 38.80 10.85 75 64616 250584 90313172
Insulin autoimmune syndrome 38.70 10.85 11 64680 159 90563597
Prescribed overdose 38.41 10.85 11 64680 97614 90466142
Depressive symptom 38.07 10.85 31 64660 5254 90558502
Neonatal respiratory distress syndrome 37.83 10.85 25 64666 3076 90560680
Dyspnoea 37.54 10.85 857 63834 880098 89683658
Lymphoedema 36.43 10.85 47 64644 13706 90550050
Completed suicide 36.42 10.85 30 64661 145028 90418728
Pre-eclampsia 36.14 10.85 42 64649 11006 90552750
Rash 36.03 10.85 379 64312 795721 89768035
Blindness transient 35.61 10.85 28 64663 4515 90559241
Appetite disorder 35.52 10.85 38 64653 9095 90554661
Tongue injury 35.32 10.85 14 64677 583 90563173
Off label use 34.75 10.85 566 64125 1101686 89462070
Sleep disorder 34.50 10.85 55 64636 197975 90365781
Polycystic ovaries 34.22 10.85 30 64661 5624 90558132
Rales 34.20 10.85 49 64642 15778 90547978
Hypoaesthesia 33.92 10.85 113 64578 314097 90249659
Productive cough 33.48 10.85 126 64565 76937 90486819
Knee arthroplasty 33.42 10.85 9 64682 83173 90480583
Autoimmune disorder 33.40 10.85 7 64684 76737 90487019
Respiratory failure 33.37 10.85 170 64521 118248 90445508
Abscess 33.04 10.85 53 64638 18838 90544918
Impaired gastric emptying 32.73 10.85 43 64648 12766 90550990
Dyspepsia 32.70 10.85 57 64634 198103 90365653
Product dispensing error 32.60 10.85 42 64649 12231 90551525
Contusion 32.45 10.85 83 64608 251133 90312623
Anaphylactic reaction 32.31 10.85 136 64555 87388 90476368
General physical health deterioration 32.29 10.85 137 64554 354978 90208778
Rhabdomyolysis 32.26 10.85 95 64596 51161 90512595
Type 1 diabetes mellitus 32.11 10.85 27 64664 4785 90558971
Gastrointestinal malformation 32.06 10.85 10 64681 202 90563554
Red blood cell sedimentation rate increased 31.23 10.85 10 64681 82585 90481171
Mental status changes 31.23 10.85 86 64605 44593 90519163
Schizencephaly 31.10 10.85 11 64680 332 90563424
Therapy non-responder 31.07 10.85 31 64660 136673 90427083
Gastrointestinal disorder congenital 30.99 10.85 9 64682 141 90563615
Cerebral haemorrhage foetal 30.95 10.85 11 64680 337 90563419
Dyslipidaemia 30.71 10.85 37 64654 10070 90553686
Loss of consciousness 30.65 10.85 188 64503 140050 90423706
Blood ketone body increased 30.55 10.85 11 64680 350 90563406
Bladder agenesis 30.47 10.85 9 64682 150 90563606
Fall 30.46 10.85 498 64193 481312 90082444
Infection 30.33 10.85 144 64547 361950 90201806
Cloacal exstrophy 30.09 10.85 9 64682 157 90563599
Genitalia external ambiguous 30.09 10.85 9 64682 157 90563599
Osteoarthritis 29.90 10.85 59 64632 195671 90368085
Urosepsis 29.78 10.85 54 64637 21178 90542578
Congenital genital malformation 29.72 10.85 9 64682 164 90563592
Flank pain 29.69 10.85 51 64640 19171 90544585
Hospitalisation 29.44 10.85 174 64517 127926 90435830
Intentional product use issue 29.31 10.85 70 64621 216822 90346934
C-reactive protein increased 29.18 10.85 53 64638 181336 90382420
Congenital ectopic bladder 28.86 10.85 8 64683 105 90563651
Nail disorder 28.75 10.85 4 64687 59063 90504693
Cellulitis 28.50 10.85 135 64556 91202 90472554
Caudal regression syndrome 28.48 10.85 9 64682 190 90563566
Dermo-hypodermitis 28.09 10.85 13 64678 794 90562962
Neural tube defect 28.09 10.85 9 64682 199 90563557
Meconium stain 27.84 10.85 9 64682 205 90563551
Polyhydramnios 27.67 10.85 19 64672 2489 90561267
Product use in unapproved indication 27.41 10.85 135 64556 336101 90227655
Hypoglycaemic encephalopathy 27.40 10.85 10 64681 331 90563425
Ultrasound antenatal screen 27.36 10.85 9 64682 217 90563539
Medical device site cellulitis 27.36 10.85 9 64682 217 90563539
Diabetic hepatopathy 27.29 10.85 5 64686 6 90563750
Diabetic gastroparesis 27.29 10.85 10 64681 335 90563421
Unresponsive to stimuli 27.26 10.85 74 64617 38047 90525709
Type 2 diabetes mellitus 27.14 10.85 66 64625 203178 90360578
Hyperglycaemic hyperosmolar nonketotic syndrome 26.95 10.85 15 64676 1354 90562402
Coronavirus test positive 26.81 10.85 13 64678 882 90562874
Fracture blisters 26.72 10.85 7 64684 73 90563683
Congenital multiplex arthrogryposis 26.72 10.85 7 64684 73 90563683
Musculoskeletal pain 26.70 10.85 51 64640 171200 90392556
Blood ketone body 26.55 10.85 7 64684 75 90563681
Restless legs syndrome 26.40 10.85 53 64638 22417 90541339
Acute myocardial infarction 26.23 10.85 69 64622 34821 90528935
Abdominal pain 26.11 10.85 412 64279 395309 90168447
Cystic fibrosis 26.07 10.85 22 64669 3919 90559837
Increased insulin requirement 25.98 10.85 7 64684 82 90563674
Abortion spontaneous 25.68 10.85 91 64600 53965 90509791
Injury 25.64 10.85 65 64626 197284 90366472
Wound infection 25.50 10.85 23 64668 106379 90457377
Tethered cord syndrome 25.04 10.85 9 64682 285 90563471
Sepsis neonatal 24.91 10.85 11 64680 602 90563154
Foot deformity 24.83 10.85 6 64685 59645 90504111
Intentional overdose 24.56 10.85 132 64559 93702 90470054
Fibromyalgia 24.50 10.85 71 64620 206198 90357558
Gait inability 24.27 10.85 42 64649 146414 90417342
Hallucination 23.96 10.85 102 64589 65857 90497899
Medical device site abscess 23.93 10.85 8 64683 203 90563553
Prescribed underdose 23.61 10.85 12 64679 75007 90488749
Hepatocellular injury 23.56 10.85 59 64632 28899 90534857
Anaemia 23.53 10.85 368 64323 352434 90211322
Cardiac failure congestive 23.28 10.85 135 64556 98559 90465197
Epilepsy 23.23 10.85 15 64676 82191 90481565
Suicide attempt 23.20 10.85 111 64580 75288 90488468
Pancreatitis 23.10 10.85 105 64586 69721 90494035
Product storage error 22.90 10.85 47 64644 20194 90543562
Onychomadesis 22.66 10.85 3 64688 45995 90517761
Dyspnoea exertional 22.66 10.85 107 64584 72181 90491575
Pancreatitis acute 22.62 10.85 62 64629 32053 90531703
Diabetic ketoacidotic hyperglycaemic coma 22.53 10.85 6 64685 67 90563689
Diabetic hyperosmolar coma 22.43 10.85 9 64682 387 90563369
Joint stiffness 22.39 10.85 14 64677 78028 90485728
Anencephaly 22.39 10.85 9 64682 389 90563367
Angina pectoris 22.23 10.85 70 64621 39090 90524666
Bicuspid aortic valve 22.19 10.85 7 64684 147 90563609
Vomiting 22.16 10.85 727 63964 787566 89776190
Toxicity to various agents 22.08 10.85 118 64573 287728 90276028
Amnesia 22.02 10.85 27 64664 108478 90455278
Sciatica 21.90 10.85 24 64667 101358 90462398
Hypervolaemia 21.85 10.85 62 64629 32695 90531061
Vision blurred 21.71 10.85 144 64547 110149 90453607
Large intestine polyp 21.68 10.85 30 64661 9356 90554400
Accidental underdose 21.60 10.85 12 64679 1079 90562677
Laryngitis 21.33 10.85 5 64686 50748 90513008
Anal atresia 21.32 10.85 9 64682 441 90563315
Generalised oedema 21.27 10.85 44 64647 19009 90544747
Immunodeficiency 20.87 10.85 3 64688 43231 90520525
Fear-related avoidance of activities 20.71 10.85 7 64684 184 90563572
Somnolence 20.54 10.85 234 64457 208850 90354906
Dextrocardia 20.27 10.85 5 64686 40 90563716
Adverse event 20.08 10.85 33 64658 117385 90446371
Coronary artery disease 19.91 10.85 61 64630 33562 90530194
Multiple lentigines syndrome 19.90 10.85 7 64684 208 90563548
Diabetic foot 19.53 10.85 13 64678 1618 90562138
Palpitations 19.27 10.85 165 64526 136563 90427193
End stage renal disease 19.21 10.85 27 64664 8544 90555212
Exostosis 19.11 10.85 7 64684 53127 90510629
Disorientation 19.05 10.85 72 64619 44042 90519714
Sepsis 18.92 10.85 204 64487 179610 90384146
Pneumonia 18.83 10.85 592 64099 637467 89926289
Fatigue 18.83 10.85 655 64036 1153368 89410388
Decreased insulin requirement 18.76 10.85 6 64685 132 90563624
Hyperglycaemic unconsciousness 18.74 10.85 3 64688 0 90563756
Dry mouth 18.63 10.85 68 64623 183991 90379765
Metabolic acidosis 18.62 10.85 84 64607 55592 90508164
Diabetic retinal oedema 18.54 10.85 8 64683 414 90563342
Device delivery system issue 18.52 10.85 13 64678 1765 90561991
Meningomyelocele 18.26 10.85 9 64682 633 90563123
Hepatic cytolysis 18.23 10.85 56 64635 30860 90532896
Pancreatic carcinoma 18.20 10.85 26 64665 8351 90555405
Hepatic encephalopathy 18.03 10.85 34 64657 13738 90550018
Hip fracture 17.75 10.85 58 64633 33019 90530737
Umbilical cord abnormality 17.74 10.85 9 64682 673 90563083
Obesity 17.71 10.85 30 64661 105477 90458279
Taste disorder 17.71 10.85 11 64680 61535 90502221
Carcinoid crisis 17.67 10.85 7 64684 291 90563465
Abortion induced 17.65 10.85 31 64660 11857 90551899
Coeliac disease 17.59 10.85 5 64686 44605 90519151
Blood insulin decreased 17.51 10.85 4 64687 22 90563734
Tinnitus 17.51 10.85 69 64622 43033 90520723
Lymphangiectasia 17.48 10.85 5 64686 74 90563682
Incorrect dose administered by device 17.43 10.85 21 64670 5716 90558040
Headache 17.39 10.85 476 64215 862270 89701486
Cholestasis 17.15 10.85 61 64630 36238 90527518
Mesenteric arterial occlusion 17.13 10.85 6 64685 176 90563580
Blood loss anaemia 17.12 10.85 28 64663 10112 90553644
Diabetic coma 17.03 10.85 9 64682 733 90563023
Back injury 17.01 10.85 6 64685 46616 90517140
Renal impairment 16.90 10.85 131 64560 105290 90458466
Therapeutic drug monitoring analysis incorrectly performed 16.76 10.85 7 64684 334 90563422
Shoulder dystocia 16.66 10.85 3 64688 3 90563753
Product administration error 16.65 10.85 49 64642 26374 90537382
Maculopathy 16.60 10.85 14 64677 2492 90561264
Peripheral swelling 16.53 10.85 202 64489 412904 90150852
Blood test abnormal 16.33 10.85 42 64649 20910 90542846
Obstructive airways disorder 16.33 10.85 48 64643 25821 90537935
Left ventricular hypertrophy 16.28 10.85 21 64670 6123 90557633
Exomphalos 16.25 10.85 8 64683 561 90563195
Acute painful neuropathy of rapid glycaemic control 16.20 10.85 3 64688 4 90563752
Product container issue 16.15 10.85 13 64678 2168 90561588
Retinopathy 16.08 10.85 16 64675 3518 90560238
Acute respiratory distress syndrome 16.02 10.85 51 64640 28635 90535121
Sopor 15.82 10.85 46 64645 24598 90539158
Expired product administered 15.80 10.85 22 64669 6900 90556856
Hepatic steatosis 15.70 10.85 60 64631 36885 90526871
Diabetic hyperglycaemic coma 15.70 10.85 4 64687 37 90563719
Congenital bladder anomaly 15.68 10.85 6 64685 227 90563529
Wrong technique in product usage process 15.66 10.85 96 64595 71475 90492281
Immunosuppressant drug level increased 15.66 10.85 18 64673 4662 90559094
Spina bifida 15.59 10.85 9 64682 871 90562885
Resting tremor 15.56 10.85 9 64682 874 90562882
Neisseria infection 15.55 10.85 5 64686 112 90563644
Foetal hypokinesia 15.52 10.85 8 64683 619 90563137
Pemphigoid 15.34 10.85 25 64666 9001 90554755
Atrial fibrillation 15.19 10.85 154 64537 133457 90430299
Hypothermia 15.13 10.85 34 64657 15541 90548215
Road traffic accident 15.12 10.85 34 64657 107592 90456164
Treatment noncompliance 15.08 10.85 75 64616 51652 90512104
Incorrect dose administered 14.90 10.85 102 64589 78828 90484928
Anti-insulin antibody increased 14.83 10.85 4 64687 47 90563709
Cardiac septal hypertrophy 14.65 10.85 6 64685 272 90563484
Syncope 14.65 10.85 152 64539 132511 90431245
Extradural haematoma 14.62 10.85 12 64679 2056 90561700
Amniorrhexis 14.61 10.85 4 64687 50 90563706
Abdominal distension 14.59 10.85 150 64541 130451 90433305
Leukocytosis 14.57 10.85 52 64639 30938 90532818
High risk pregnancy 14.56 10.85 5 64686 138 90563618
Therapeutic drug monitoring analysis not performed 14.50 10.85 10 64681 1319 90562437
Jaundice neonatal 14.44 10.85 9 64682 1001 90562755
Fluid retention 14.42 10.85 110 64581 87981 90475775
Swollen tongue 14.38 10.85 68 64623 45888 90517868
Finger deformity 14.31 10.85 3 64688 32894 90530862
Essential hypertension 14.31 10.85 20 64671 6295 90557461
Blood creatine phosphokinase increased 14.25 10.85 55 64636 33968 90529788
Trisomy 18 14.23 10.85 5 64686 148 90563608
Vitreous haemorrhage 14.05 10.85 13 64678 2613 90561143
Butterfly rash 14.05 10.85 12 64679 2173 90561583
Troponin increased 14.04 10.85 30 64661 13251 90550505
Pyelonephritis 13.88 10.85 40 64651 21276 90542480
Blood insulin increased 13.83 10.85 5 64686 161 90563595
Accidental overdose 13.78 10.85 48 64643 28225 90535531
Macrosomia 13.75 10.85 4 64687 63 90563693
Acidosis 13.73 10.85 29 64662 12707 90551049
Blood pressure decreased 13.67 10.85 96 64595 74799 90488957
Congenital aortic valve stenosis 13.64 10.85 4 64687 65 90563691
Oedema peripheral 13.55 10.85 259 64432 257656 90306100
Renal hypertension 13.55 10.85 5 64686 171 90563585
Lung disorder 13.49 10.85 58 64633 149825 90413931
Hypophagia 13.38 10.85 56 64635 35881 90527875
Macular oedema 13.35 10.85 17 64674 4892 90558864
Blindness cortical 13.04 10.85 7 64684 588 90563168
Injection site reaction 13.01 10.85 29 64662 92051 90471705
Anogenital warts 13.01 10.85 7 64684 591 90563165
Blood ketone body present 12.91 10.85 4 64687 79 90563677
Therapeutic response decreased 12.89 10.85 28 64663 89701 90474055
Threatened labour 12.84 10.85 8 64683 890 90562866
Sputum increased 12.75 10.85 13 64678 2944 90560812
Selective eating disorder 12.64 10.85 11 64680 2042 90561714
Weight increased 12.63 10.85 216 64475 417711 90146045
Paraesthesia 12.60 10.85 116 64575 250210 90313546
Pancreas transplant 12.51 10.85 3 64688 21 90563735
Cystitis 12.46 10.85 86 64605 66632 90497124
Splenic thrombosis 12.39 10.85 3 64688 22 90563734
Myelosuppression 12.35 10.85 12 64679 53579 90510177
Drug interaction 12.34 10.85 271 64420 276182 90287574
Pharyngeal swelling 12.34 10.85 24 64667 9920 90553836
Gout 12.33 10.85 33 64658 16826 90546930
Haemodialysis complication 12.31 10.85 5 64686 222 90563534
Agitation 12.25 10.85 86 64605 67012 90496744
Type III immune complex mediated reaction 12.24 10.85 6 64685 417 90563339
Glucose-6-phosphate dehydrogenase deficiency 12.12 10.85 5 64686 231 90563525
Suspected product quality issue 12.12 10.85 6 64685 426 90563330
Medical device site infection 12.11 10.85 6 64685 427 90563329
Congenital diaphragmatic hernia 12.08 10.85 5 64686 233 90563523
Polymorphic light eruption 12.05 10.85 3 64688 25 90563731
Urachal abnormality 12.02 10.85 5 64686 236 90563520
Thirst 12.02 10.85 32 64659 16263 90547493
Device operational issue 11.97 10.85 8 64683 1002 90562754
COVID-19 11.96 10.85 178 64513 168665 90395091
Eye haemorrhage 11.94 10.85 24 64667 10156 90553600
Intestinal malrotation 11.94 10.85 6 64685 440 90563316
Swelling face 11.90 10.85 99 64592 81253 90482503
Ataxia 11.89 10.85 34 64657 18008 90545748
Condition aggravated 11.86 10.85 329 64362 595216 89968540
Neutropenia 11.85 10.85 103 64588 224801 90338955
Persistent cloaca 11.77 10.85 5 64686 249 90563507
Cataract subcapsular 11.70 10.85 7 64684 724 90563032
Visual acuity reduced 11.63 10.85 40 64651 23370 90540386
Respiratory tract haemorrhage 11.60 10.85 6 64685 467 90563289
Hyponatraemia 11.59 10.85 146 64545 133392 90430364
Liver disorder 11.49 10.85 46 64645 121223 90442533
Carpal tunnel decompression 11.47 10.85 8 64683 1075 90562681
Intraventricular haemorrhage neonatal 11.46 10.85 5 64686 266 90563490
Sleep disorder therapy 11.45 10.85 6 64685 480 90563276
Device malfunction 11.45 10.85 37 64654 20940 90542816
Non-alcoholic steatohepatitis 11.42 10.85 10 64681 1872 90561884
Congenital mitral valve incompetence 11.39 10.85 3 64688 32 90563724
Adverse drug reaction 11.23 10.85 44 64647 116657 90447099
Blindness 11.17 10.85 43 64648 26525 90537231
Bronchitis 11.14 10.85 162 64529 152765 90410991
Arthritis 11.01 10.85 72 64619 167243 90396513
Urinary hesitation 10.93 10.85 11 64680 2452 90561304
Hypernatraemia 10.86 10.85 22 64669 9365 90554391
Necrobiosis lipoidica diabeticorum 10.85 10.85 3 64688 39 90563717
DNA antibody negative 10.85 10.85 3 64688 39 90563717

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 1315.34 11.16 930 64855 58924 42496626
Blood glucose increased 740.00 11.16 728 65057 72971 42482579
Diabetic ketoacidosis 692.77 11.16 431 65354 21936 42533614
Blood glucose decreased 380.55 11.16 250 65535 13969 42541581
Diabetes mellitus inadequate control 362.57 11.16 250 65535 15140 42540410
Hyperglycaemia 303.50 11.16 364 65421 45495 42510055
Appendicolith 264.96 11.16 196 65589 13260 42542290
Hypoglycaemic coma 252.59 11.16 110 65675 2634 42552916
Blood glucose fluctuation 229.64 11.16 121 65664 4466 42551084
Hypoglycaemic unconsciousness 207.20 11.16 68 65717 716 42554834
Appendicitis 207.11 11.16 204 65581 20409 42535141
Pulmonary vasculitis 179.47 11.16 115 65670 6151 42549399
Respiratory symptom 162.92 11.16 136 65649 10970 42544580
Neuritis 146.35 11.16 101 65684 6119 42549431
Blood phosphorus increased 139.09 11.16 131 65654 12394 42543156
Toxicity to various agents 136.96 11.16 93 65692 229043 42326507
Cardiogenic shock 136.02 11.16 217 65568 35423 42520127
Drug ineffective 134.40 11.16 511 65274 629686 41925864
Ascites 130.02 11.16 277 65508 56401 42499149
Stress 129.03 11.16 239 65546 43973 42511577
Drug abuse 126.89 11.16 9 65776 104762 42450788
Ventricular fibrillation 124.11 11.16 190 65595 29933 42525617
Total lung capacity abnormal 120.98 11.16 79 65706 4364 42551186
Myasthenia gravis 119.86 11.16 136 65649 16001 42539549
Abdominal distension 117.10 11.16 307 65478 71428 42484122
Eosinophilic granulomatosis with polyangiitis 110.87 11.16 98 65687 8540 42547010
Neurological symptom 109.98 11.16 104 65681 9887 42545663
Hyperphosphataemia 109.40 11.16 117 65668 12887 42542663
Ketoacidosis 107.68 11.16 79 65706 5273 42550277
Glycosylated haemoglobin increased 94.42 11.16 108 65677 12816 42542734
Diabetic retinopathy 90.89 11.16 50 65735 2013 42553537
Pulmonary alveolar haemorrhage 90.46 11.16 113 65672 14703 42540847
Spirometry abnormal 88.14 11.16 69 65716 5077 42550473
Analgesic therapy 87.72 11.16 76 65709 6448 42549102
Product quality issue 85.50 11.16 121 65664 17761 42537789
Vasculitis 84.33 11.16 122 65663 18272 42537278
Sleep disorder therapy 84.09 11.16 76 65709 6818 42548732
Hyponatraemia 82.78 11.16 343 65442 101119 42454431
Incorrect route of product administration 81.96 11.16 140 65645 24165 42531385
Forced expiratory volume decreased 79.39 11.16 77 65708 7553 42547997
Blood uric acid increased 77.01 11.16 107 65678 15440 42540110
Blood glucose abnormal 76.83 11.16 73 65712 6980 42548570
Drug therapy 75.21 11.16 69 65716 6311 42549239
Conjunctivitis allergic 73.75 11.16 66 65719 5845 42549705
Mite allergy 72.36 11.16 61 65724 4985 42550565
Normochromic normocytic anaemia 72.02 11.16 79 65706 8952 42546598
Mycotic allergy 71.95 11.16 60 65725 4831 42550719
Hypophosphataemia 71.09 11.16 121 65664 20824 42534726
Dust allergy 69.44 11.16 61 65724 5271 42550279
Diabetic metabolic decompensation 68.81 11.16 42 65743 2060 42553490
Thrombosis 67.59 11.16 246 65539 68265 42487285
Antineutrophil cytoplasmic antibody positive 67.24 11.16 55 65730 4310 42551240
Pulmonary fibrosis 66.53 11.16 135 65650 26546 42529004
Hypoglycaemic seizure 64.41 11.16 24 65761 377 42555173
Disease progression 62.40 11.16 78 65707 143578 42411972
Full blood count abnormal 61.66 11.16 140 65645 29736 42525814
Antacid therapy 61.50 11.16 54 65731 4663 42550887
Neuralgia 59.53 11.16 126 65659 25521 42530029
Diabetic foot 58.77 11.16 44 65741 3029 42552521
End stage renal disease 57.98 11.16 97 65688 16461 42539089
Bacterial infection 57.93 11.16 131 65654 27748 42527802
Obstructive airways disorder 57.89 11.16 122 65663 24637 42530913
Completed suicide 57.74 11.16 39 65746 96426 42459124
Product leakage 57.47 11.16 27 65758 775 42554775
Anticoagulant therapy 57.30 11.16 51 65734 4484 42551066
Sleep disorder due to a general medical condition 56.83 11.16 99 65686 17354 42538196
Lung disorder 56.83 11.16 183 65602 47740 42507810
Sleep disorder 55.54 11.16 182 65603 47913 42507637
Off label use 54.58 11.16 678 65107 637657 41917893
Dry mouth 54.47 11.16 160 65625 39719 42515831
Hypothyroidism 54.04 11.16 139 65646 31945 42523605
General physical health deterioration 54.04 11.16 409 65376 150837 42404713
Anti-insulin antibody positive 52.58 11.16 17 65768 170 42555380
Trisomy 18 52.54 11.16 26 65759 839 42554711
Blood cholesterol increased 51.55 11.16 122 65663 26619 42528931
Hydrops foetalis 51.42 11.16 26 65759 879 42554671
Cleft lip and palate 50.70 11.16 26 65759 906 42554644
Activated partial thromboplastin time prolonged 50.22 11.16 89 65696 15814 42539736
Febrile neutropenia 49.41 11.16 136 65649 185567 42369983
Multiple organ dysfunction syndrome 46.35 11.16 282 65503 96753 42458797
Iron deficiency 45.87 11.16 70 65715 10991 42544559
Acute kidney injury 44.94 11.16 806 64979 366531 42189019
Nodule 44.65 11.16 74 65711 12460 42543090
Insulin autoimmune syndrome 44.64 11.16 20 65765 513 42555037
Vomiting 44.06 11.16 659 65126 289064 42266486
Haemoptysis 44.03 11.16 164 65621 46003 42509547
Hypoglycaemia neonatal 43.84 11.16 32 65753 2118 42553432
Treatment failure 43.64 11.16 21 65764 62603 42492947
Ultrasound antenatal screen 43.56 11.16 20 65765 544 42555006
Liquid product physical issue 42.37 11.16 22 65763 787 42554763
Diabetic neuropathy 42.33 11.16 43 65742 4459 42551091
Hyperkalaemia 41.76 11.16 239 65546 80219 42475331
Sepsis 41.38 11.16 480 65305 198854 42356696
Capillaritis 40.61 11.16 31 65754 2197 42553353
Aortic stenosis 40.07 11.16 58 65727 8687 42546863
Bronchopulmonary aspergillosis allergic 39.78 11.16 42 65743 4556 42550994
Insulin resistance 39.43 11.16 21 65764 792 42554758
Diabetic nephropathy 39.25 11.16 31 65754 2310 42553240
Troponin increased 36.77 11.16 87 65698 18975 42536575
Increased insulin requirement 36.25 11.16 12 65773 130 42555420
Hyperlipidaemia 36.01 11.16 93 65692 21423 42534127
Congenital hiatus hernia 35.96 11.16 46 65739 6128 42549422
Gout 35.89 11.16 110 65675 27945 42527605
Chronic kidney disease 34.86 11.16 155 65630 47086 42508464
Arteriosclerosis 34.59 11.16 82 65703 17907 42537643
Bacteroides infection 34.50 11.16 30 65755 2557 42552993
Blood calcium increased 34.35 11.16 53 65732 8401 42547149
Ulcer 33.87 11.16 77 65708 16364 42539186
Arteriosclerosis coronary artery 32.57 11.16 82 65703 18595 42536955
Myelosuppression 32.37 11.16 11 65774 40450 42515100
Diabetic complication 32.22 11.16 18 65767 747 42554803
Hypoglycaemia unawareness 31.28 11.16 11 65774 145 42555405
Wrong product administered 31.05 11.16 43 65742 6183 42549367
Abortion spontaneous 30.18 11.16 14 65771 390 42555160
Hypoglycaemic encephalopathy 29.93 11.16 13 65772 309 42555241
Cutaneous amyloidosis 29.53 11.16 8 65777 40 42555510
Constipation 29.40 11.16 381 65404 161910 42393640
Blood ketone body increased 29.24 11.16 15 65770 523 42555027
Abdominal pain 29.18 11.16 434 65351 190037 42365513
Asthma 29.05 11.16 180 65605 62134 42493416
Diabetic ketosis 28.87 11.16 12 65773 255 42555295
Infusion related reaction 28.54 11.16 31 65754 60775 42494775
Overdose 28.03 11.16 77 65708 105187 42450363
Pulmonary valve stenosis congenital 28.02 11.16 10 65775 138 42555412
Pulmonary embolism 27.97 11.16 295 65490 119317 42436233
Therapy non-responder 27.58 11.16 25 65760 53334 42502216
Swelling 26.50 11.16 160 65625 54725 42500825
Aggression 26.22 11.16 18 65767 44145 42511405
Pemphigoid 26.21 11.16 56 65729 11411 42544139
Neutropenia 25.77 11.16 191 65594 199240 42356310
Hepatotoxicity 25.76 11.16 4 65781 25163 42530387
Device malfunction 25.69 11.16 58 65727 12269 42543281
Haematochezia 25.06 11.16 32 65753 58404 42497146
Total lung capacity decreased 24.68 11.16 29 65756 3541 42552009
Drug resistance 24.61 11.16 11 65774 34237 42521313
Arthralgia 24.45 11.16 201 65584 205037 42350513
Periodontitis 24.30 11.16 23 65762 2188 42553362
Lymphangitis 23.87 11.16 14 65771 638 42554912
Vitreous haemorrhage 23.60 11.16 25 65760 2722 42552828
Nightmare 23.39 11.16 5 65780 25007 42530543
Mucosal inflammation 23.36 11.16 25 65760 49349 42506201
Chronic obstructive pulmonary disease 22.68 11.16 171 65614 62943 42492607
Gallbladder neoplasm 22.49 11.16 6 65779 28 42555522
Bronchopneumopathy 22.29 11.16 13 65772 586 42554964
Diabetic macroangiopathy 22.24 11.16 5 65780 9 42555541
Diabetic ketoacidotic hyperglycaemic coma 22.20 11.16 9 65776 179 42555371
Anti-insulin antibody 21.99 11.16 6 65779 31 42555519
Cystic fibrosis 21.87 11.16 21 65764 2034 42553516
Wheezing 21.74 11.16 152 65633 54629 42500921
Infective pulmonary exacerbation of cystic fibrosis 21.22 11.16 41 65744 7777 42547773
Hallucination 21.21 11.16 35 65750 57472 42498078
Cold sweat 21.08 11.16 51 65734 11279 42544271
Serotonin syndrome 20.72 11.16 7 65778 25838 42529712
Impaired gastric emptying 20.07 11.16 29 65756 4337 42551213
Sedation 20.06 11.16 11 65774 30464 42525086
Diabetes mellitus 20.03 11.16 160 65625 59927 42495623
Blood test abnormal 19.78 11.16 54 65731 12852 42542698
Malignant neoplasm progression 19.74 11.16 93 65692 108307 42447243
Adenocarcinoma pancreas 19.27 11.16 17 65768 1477 42554073
Cough 19.17 11.16 179 65606 177924 42377626
Pleuritic pain 19.07 11.16 37 65748 7040 42548510
Pyrexia 19.07 11.16 463 65322 393579 42161971
Toe amputation 18.94 11.16 23 65762 2906 42552644
Product physical issue 18.89 11.16 24 65761 3175 42552375
Intentional product use issue 18.78 11.16 53 65732 71780 42483770
Microsporidia infection 18.77 11.16 15 65770 1137 42554413
Congenital bladder anomaly 18.70 11.16 9 65776 273 42555277
Rash 18.62 11.16 308 65477 276646 42278904
Product use in unapproved indication 17.93 11.16 190 65595 184266 42371284
Measles 17.65 11.16 9 65776 310 42555240
Loss of consciousness 17.63 11.16 219 65566 92135 42463415
Intentional product misuse 17.56 11.16 159 65626 61741 42493809
Foetal exposure during pregnancy 17.45 11.16 129 65656 47182 42508368
Osteitis 17.36 11.16 17 65768 1687 42553863
Blood pressure fluctuation 17.30 11.16 10 65775 26898 42528652
Therapeutic product effect decreased 17.24 11.16 21 65764 39129 42516421
Congenital cystic kidney disease 17.20 11.16 10 65775 448 42555102
Drug ineffective for unapproved indication 17.11 11.16 28 65757 46135 42509415
Euglycaemic diabetic ketoacidosis 17.00 11.16 31 65754 5629 42549921
Genitalia external ambiguous 16.95 11.16 8 65777 232 42555318
Campylobacter test positive 16.80 11.16 6 65779 83 42555467
Nausea 16.45 11.16 759 65026 396040 42159510
Product contamination with body fluid 16.43 11.16 3 65782 0 42555550
Diabetic gangrene 16.31 11.16 8 65777 253 42555297
Rhinorrhoea 16.30 11.16 15 65770 31779 42523771
Diabetic coma 16.24 11.16 13 65772 988 42554562
Acute myeloid leukaemia 16.22 11.16 7 65778 22249 42533301
Pain 16.22 11.16 273 65512 244575 42310975
Skin ulcer 15.96 11.16 80 65705 25521 42530029
Sinusitis 15.46 11.16 31 65754 47261 42508289
Device failure 15.29 11.16 20 65765 2723 42552827
Pancytopenia 15.08 11.16 113 65672 117630 42437920
Blood creatinine increased 15.05 11.16 246 65539 109757 42445793
Respiratory failure 15.01 11.16 126 65659 128006 42427544
Blood pressure increased 14.94 11.16 94 65691 101834 42453716
Heart rate increased 14.89 11.16 38 65747 53217 42502333
Varicose vein 14.83 11.16 15 65770 1547 42554003
Depression 14.68 11.16 106 65679 111257 42444293
Therapeutic drug monitoring analysis incorrectly performed 14.66 11.16 8 65777 317 42555233
Renal aplasia 14.50 11.16 11 65774 772 42554778
Haemophagocytic lymphohistiocytosis 14.49 11.16 5 65780 18217 42537333
Polycythaemia neonatorum 14.35 11.16 3 65782 3 42555547
Peripheral artery haematoma 14.28 11.16 5 65780 65 42555485
Drug reaction with eosinophilia and systemic symptoms 14.26 11.16 27 65758 42048 42513502
Skin wrinkling 14.18 11.16 9 65776 473 42555077
Gangrene 14.06 11.16 27 65758 5099 42550451
Hyperinsulinaemic hypoglycaemia 14.04 11.16 6 65779 137 42555413
Gingival hypertrophy 13.93 11.16 18 65767 2421 42553129
Somnolence 13.92 11.16 300 65485 140805 42414745
Truncus arteriosus persistent 13.75 11.16 4 65781 27 42555523
Neutrophil count decreased 13.65 11.16 51 65734 63364 42492186
Poisoning 13.62 11.16 3 65782 14696 42540854
Nasopharyngitis 13.62 11.16 75 65710 83921 42471629
Hunger 13.49 11.16 16 65769 1972 42553578
Microalbuminuria 13.43 11.16 11 65774 863 42554687
Aspiration 13.42 11.16 59 65726 17827 42537723
Dyspnoea 13.38 11.16 822 64963 441799 42113751
Headache 13.33 11.16 275 65510 239094 42316456
Foetal hypokinesia 13.30 11.16 8 65777 382 42555168
Haemolytic anaemia 13.20 11.16 45 65740 12082 42543468
Prostate cancer 13.16 11.16 31 65754 44612 42510938
Ketosis 13.10 11.16 11 65774 894 42554656
Cardiac arrest 13.03 11.16 107 65678 109213 42446337
Insulin-requiring type 2 diabetes mellitus 12.97 11.16 6 65779 166 42555384
Rheumatoid arthritis 12.89 11.16 29 65756 42411 42513139
Pancreatic carcinoma 12.84 11.16 38 65747 9468 42546082
Vitamin B12 increased 12.77 11.16 8 65777 411 42555139
Diabetic foot infection 12.77 11.16 10 65775 736 42554814
Oedema peripheral 12.69 11.16 287 65498 135789 42419761
Hyperglycaemic hyperosmolar nonketotic syndrome 12.63 11.16 14 65771 1604 42553946
Herpes zoster reactivation 12.60 11.16 8 65777 421 42555129
Myelodysplastic syndrome 12.55 11.16 10 65775 22735 42532815
Leukopenia 12.53 11.16 66 65719 74680 42480870
Cardiovascular disorder 12.34 11.16 47 65738 13318 42542232
Spermatic cord disorder 12.28 11.16 3 65782 9 42555541
Hypoxia 12.26 11.16 163 65622 69623 42485927
Dysmetria 12.23 11.16 10 65775 783 42554767
Brain oedema 12.12 11.16 5 65780 16322 42539228
Neonatal respiratory depression 11.99 11.16 8 65777 458 42555092
Micturition urgency 11.95 11.16 43 65742 11855 42543695
COVID-19 11.85 11.16 118 65667 115830 42439720
Product storage error 11.83 11.16 41 65744 11099 42544451
Paraesthesia 11.69 11.16 66 65719 73393 42482157
Lung opacity 11.65 11.16 27 65758 5810 42549740
Basophil count abnormal 11.62 11.16 3 65782 12 42555538
Tachycardia 11.56 11.16 100 65685 100987 42454563
Cardiac output decreased 11.55 11.16 11 65774 1054 42554496
Foot amputation 11.55 11.16 10 65775 847 42554703
Suicidal ideation 11.53 11.16 37 65748 48124 42507426
Pneumonitis 11.49 11.16 30 65755 41688 42513862
Suspected product tampering 11.42 11.16 3 65782 13 42555537
Drug dependence 11.40 11.16 17 65768 29077 42526473
Dry gangrene 11.38 11.16 8 65777 499 42555051
Haemorrhagic stroke 11.37 11.16 31 65754 7371 42548179
Disseminated intravascular coagulation 11.24 11.16 13 65772 24781 42530769
Inflammation 11.22 11.16 22 65763 33825 42521725
Hepatic cirrhosis 11.19 11.16 60 65725 19642 42535908

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 2850.08 10.26 1660 111273 114444 110361922
Diabetic ketoacidosis 2163.24 10.26 990 111943 41068 110435298
Blood glucose increased 1796.36 10.26 1306 111627 131190 110345176
Blood glucose decreased 787.01 10.26 446 112487 29042 110447324
Hyperglycaemia 782.85 10.26 668 112265 84422 110391944
Diabetes mellitus inadequate control 742.90 10.26 431 112502 29344 110447022
Hypoglycaemic coma 519.14 10.26 200 112733 5333 110471033
Blood glucose fluctuation 394.71 10.26 181 112752 7517 110468849
Hypoglycaemic unconsciousness 379.69 10.26 109 112824 1111 110475255
Appendicolith 344.01 10.26 202 112731 14053 110462313
Acute kidney injury 338.10 10.26 1413 111520 634017 109842349
Ketoacidosis 333.96 10.26 176 112757 9911 110466455
Diabetic retinopathy 296.20 10.26 118 112815 3446 110472920
Glycosylated haemoglobin increased 262.26 10.26 207 112726 23412 110452954
Appendicitis 258.57 10.26 222 112711 28242 110448124
Synovitis 230.43 10.26 12 112921 274080 110202286
Pulmonary vasculitis 221.54 10.26 116 112817 6444 110469922
Diabetic metabolic decompensation 216.98 10.26 97 112836 3792 110472574
Infusion related reaction 210.17 10.26 64 112869 381098 110095268
Hand deformity 207.42 10.26 3 112930 218503 110257863
Product leakage 205.22 10.26 73 112860 1545 110474821
Arthropathy 190.99 10.26 32 112901 287490 110188876
Blood glucose abnormal 189.92 10.26 134 112799 12782 110463584
Glossodynia 182.63 10.26 11 112922 221993 110254373
Respiratory symptom 178.99 10.26 137 112796 14808 110461558
Systemic lupus erythematosus 178.82 10.26 24 112909 254314 110222052
Neuritis 173.68 10.26 103 112830 7296 110469070
Blood phosphorus increased 172.42 10.26 139 112794 16201 110460165
Treatment failure 171.09 10.26 37 112896 277197 110199169
Joint swelling 164.41 10.26 127 112806 442718 110033648
Drug ineffective 163.27 10.26 901 112032 1519639 108956727
Total lung capacity abnormal 154.65 10.26 81 112852 4502 110471864
Ventricular fibrillation 151.98 10.26 199 112734 41114 110435252
Myasthenia gravis 150.68 10.26 145 112788 21366 110455000
Helicobacter infection 149.63 10.26 9 112924 181868 110294498
Cardiogenic shock 147.49 10.26 233 112700 57105 110419261
Alopecia 146.66 10.26 96 112837 364657 110111709
Folliculitis 145.22 10.26 6 112927 167647 110308719
Hyperphosphataemia 145.20 10.26 126 112807 16255 110460111
Pericarditis 144.14 10.26 25 112908 219089 110257277
Irritable bowel syndrome 141.83 10.26 6 112927 164209 110312157
Ascites 138.34 10.26 298 112635 92510 110383856
Eosinophilic granulomatosis with polyangiitis 130.26 10.26 99 112834 10587 110465779
Therapeutic product effect decreased 129.33 10.26 44 112889 244272 110232094
Stress 129.04 10.26 313 112620 105035 110371331
Anti-insulin antibody positive 127.46 10.26 34 112899 257 110476109
Lactic acidosis 125.92 10.26 287 112646 92524 110383842
Contraindicated product administered 125.83 10.26 48 112885 248219 110228147
Muscle injury 125.55 10.26 4 112929 140803 110335563
Hyperkalaemia 125.20 10.26 363 112570 135433 110340933
Analgesic therapy 124.68 10.26 83 112850 7201 110469165
Abdominal distension 123.76 10.26 427 112506 174676 110301690
Sleep disorder therapy 122.76 10.26 83 112850 7388 110468978
Arthralgia 122.22 10.26 399 112534 779233 109697133
Human rhinovirus test positive 119.92 10.26 46 112887 1211 110475155
Respiratory syncytial virus test positive 119.08 10.26 48 112885 1446 110474920
Rheumatoid arthritis 118.87 10.26 80 112853 299533 110176833
Toxicity to various agents 118.02 10.26 193 112740 480362 109996004
Diabetic neuropathy 117.98 10.26 79 112854 6920 110469446
Hypoglycaemic seizure 116.29 10.26 42 112891 930 110475436
Spirometry abnormal 114.80 10.26 71 112862 5426 110470940
Pain 112.74 10.26 547 112386 954408 109521958
Neurological symptom 108.92 10.26 105 112828 15503 110460863
Pulmonary alveolar haemorrhage 108.71 10.26 118 112815 20032 110456334
Drug therapy 108.02 10.26 76 112857 7215 110469151
C-reactive protein abnormal 107.95 10.26 6 112927 129689 110346677
Hypoglycaemia unawareness 106.72 10.26 29 112904 237 110476129
Bursitis 102.27 10.26 8 112925 129910 110346456
Blood uric acid increased 100.63 10.26 117 112816 21412 110454954
Psoriatic arthropathy 99.76 10.26 38 112895 196723 110279643
Liquid product physical issue 99.26 10.26 43 112890 1557 110474809
Sinusitis 99.16 10.26 94 112839 296594 110179772
Hepatic enzyme increased 97.83 10.26 110 112823 320782 110155584
End stage renal disease 97.54 10.26 115 112818 21358 110455008
Abdominal discomfort 96.84 10.26 158 112775 393700 110082666
Thrombosis 95.88 10.26 286 112647 108376 110367990
Completed suicide 95.75 10.26 65 112868 242316 110234050
Mobility decreased 94.69 10.26 63 112870 237359 110239007
Forced expiratory volume decreased 94.52 10.26 90 112843 13086 110463280
Wound 93.78 10.26 62 112871 234375 110241991
Impaired healing 93.27 10.26 42 112891 196675 110279691
Obstructive airways disorder 92.74 10.26 168 112765 45981 110430385
Product quality issue 90.76 10.26 226 112707 77073 110399293
Dust allergy 89.95 10.26 63 112870 5938 110470428
Mite allergy 89.50 10.26 62 112871 5741 110470625
Hyponatraemia 89.21 10.26 449 112484 217204 110259162
Conjunctivitis allergic 88.45 10.26 66 112867 6865 110469501
Diabetic ketosis 88.39 10.26 34 112899 902 110475464
Antacid therapy 87.91 10.26 60 112873 5424 110470942
Sepsis 87.33 10.26 603 112330 326743 110149623
Viral test positive 86.89 10.26 33 112900 845 110475521
Insulin resistance 86.48 10.26 40 112893 1694 110474672
Chronic kidney disease 86.38 10.26 220 112713 76071 110400295
Normochromic normocytic anaemia 85.81 10.26 85 112848 12972 110463394
Mycotic allergy 85.75 10.26 61 112872 5893 110470473
Hypophosphataemia 85.54 10.26 135 112798 33047 110443319
Lip dry 85.28 10.26 4 112929 100079 110376287
Insulin autoimmune syndrome 84.82 10.26 31 112902 711 110475655
Ill-defined disorder 83.42 10.26 28 112905 156825 110319541
Discomfort 82.92 10.26 59 112874 214648 110261718
Antineutrophil cytoplasmic antibody positive 82.47 10.26 56 112877 5020 110471346
Anticoagulant therapy 82.03 10.26 57 112876 5304 110471062
Nasopharyngitis 80.44 10.26 177 112756 394184 110082182
Multiple organ dysfunction syndrome 79.97 10.26 337 112596 151373 110324993
Diabetic nephropathy 77.58 10.26 47 112886 3461 110472905
Infective pulmonary exacerbation of cystic fibrosis 77.07 10.26 85 112848 14686 110461680
Diabetic foot 75.78 10.26 49 112884 4046 110472320
Haemoptysis 73.87 10.26 199 112734 71155 110405211
Hyper IgE syndrome 72.49 10.26 27 112906 654 110475712
Hydrops foetalis 72.44 10.26 28 112905 753 110475613
Dehydration 71.66 10.26 510 112423 279001 110197365
Hypersensitivity 71.64 10.26 195 112738 403803 110072563
Ultrasound antenatal screen 71.55 10.26 27 112906 679 110475687
Euglycaemic diabetic ketoacidosis 71.49 10.26 73 112860 11550 110464816
Product physical issue 71.16 10.26 51 112882 4985 110471381
Ketosis 70.83 10.26 35 112898 1719 110474647
Joint range of motion decreased 69.76 10.26 19 112914 121813 110354553
Drug abuse 69.49 10.26 48 112885 177363 110299003
Oesophageal spasm 68.17 10.26 44 112889 3622 110472744
Wrong product administered 67.71 10.26 69 112864 10891 110465475
Activated partial thromboplastin time prolonged 67.59 10.26 98 112835 22270 110454096
Inflammation 67.18 10.26 59 112874 193179 110283187
Troponin increased 67.12 10.26 114 112819 29652 110446714
Off label use 66.78 10.26 1105 111828 1499080 108977286
Blood ketone body increased 65.54 10.26 27 112906 861 110475505
Liver injury 63.99 10.26 37 112896 150376 110325990
Trisomy 18 63.84 10.26 24 112909 597 110475769
Drug intolerance 63.58 10.26 208 112725 406304 110070062
Grip strength decreased 62.92 10.26 5 112928 80169 110396197
Vasculitis 62.65 10.26 123 112810 35750 110440616
Heart sounds 62.14 10.26 28 112905 1115 110475251
Pneumonia haemophilus 61.65 10.26 37 112896 2678 110473688
Neuralgia 61.45 10.26 146 112787 48332 110428034
Abdominal pain 61.22 10.26 796 112137 512193 109964173
Aortic stenosis 61.08 10.26 71 112862 12988 110463378
Gout 61.00 10.26 123 112810 36443 110439923
Bacterial infection 60.92 10.26 141 112792 45895 110430471
Increased insulin requirement 60.26 10.26 18 112915 213 110476153
Cleft lip and palate 60.01 10.26 24 112909 708 110475658
Tongue biting 58.95 10.26 37 112896 2902 110473464
Intentional product use issue 58.54 10.26 102 112831 247804 110228562
Night sweats 58.38 10.26 32 112901 133951 110342415
Blister 57.94 10.26 89 112844 227287 110249079
Iron deficiency 57.37 10.26 82 112851 18394 110457972
Peripheral venous disease 56.62 10.26 9 112924 84108 110392258
Diabetes mellitus 54.90 10.26 224 112709 99157 110377209
Full blood count abnormal 54.71 10.26 153 112780 55899 110420467
Prolonged expiration 54.00 10.26 28 112905 1524 110474842
Hypoglycaemic encephalopathy 53.71 10.26 22 112911 691 110475675
Arteriosclerosis 53.41 10.26 93 112840 24674 110451692
Congenital hiatus hernia 53.17 10.26 47 112886 6212 110470154
Osteoarthritis 53.05 10.26 65 112868 182558 110293808
Therapy non-responder 52.34 10.26 50 112883 157257 110319109
Incorrect route of product administration 52.19 10.26 164 112769 63897 110412469
Hyperhidrosis 51.67 10.26 348 112585 186950 110289416
Mouth haemorrhage 51.20 10.26 66 112867 13422 110462944
Oesophageal pain 50.71 10.26 42 112891 5083 110471283
Product use issue 50.46 10.26 157 112776 311538 110164828
Hypoaesthesia 50.35 10.26 159 112774 314064 110162302
Rash 49.94 10.26 567 112366 820397 109655969
Arteriosclerosis coronary artery 49.90 10.26 91 112842 25027 110451339
Capillaritis 49.66 10.26 31 112902 2408 110473958
Sleep disorder due to a general medical condition 49.64 10.26 141 112792 51971 110424395
Pemphigoid 49.17 10.26 79 112854 19628 110456738
Gastrointestinal disorder 48.96 10.26 109 112824 241843 110234523
Musculoskeletal stiffness 48.14 10.26 137 112796 279685 110196681
Vomiting 47.75 10.26 1242 111691 909433 109566933
Hyperlipidaemia 47.66 10.26 110 112823 35738 110440628
Dyspnoea 47.63 10.26 1472 111461 1105400 109370966
Ketonuria 47.39 10.26 25 112908 1410 110474956
Loss of consciousness 47.31 10.26 353 112580 195953 110280413
Nail disorder 47.23 10.26 3 112930 57932 110418434
Autoimmune disorder 46.42 10.26 6 112927 65477 110410889
Stomatitis 45.98 10.26 133 112800 270109 110206257
Hypothyroidism 45.69 10.26 171 112762 72728 110403638
Red blood cell sedimentation rate increased 45.22 10.26 12 112921 78290 110398076
Hip arthroplasty 45.18 10.26 3 112930 55810 110420556
C-reactive protein increased 45.06 10.26 97 112836 217822 110258544
Diabetic ketoacidotic hyperglycaemic coma 44.74 10.26 15 112918 264 110476102
Headache 44.17 10.26 635 112298 881742 109594624
Musculoskeletal pain 43.48 10.26 75 112858 182948 110293418
Productive cough 43.46 10.26 231 112702 114074 110362292
Contusion 43.34 10.26 110 112823 233251 110243115
Blood test abnormal 42.89 10.26 92 112841 28462 110447904
Bacteroides infection 42.25 10.26 30 112903 2889 110473477
Diabetic hepatopathy 42.08 10.26 8 112925 7 110476359
Myelosuppression 41.87 10.26 22 112911 94318 110382048
Infection 41.69 10.26 209 112724 361991 110114375
Myocardial infarction 41.62 10.26 337 112596 191746 110284620
Somnolence 40.36 10.26 473 112460 296976 110179390
Dyspepsia 40.32 10.26 84 112849 190881 110285485
Cold sweat 40.25 10.26 77 112856 21954 110454412
Cutaneous amyloidosis 40.22 10.26 10 112923 55 110476311
Vitreous haemorrhage 39.86 10.26 35 112898 4585 110471781
Restrictive pulmonary disease 39.30 10.26 30 112903 3229 110473137
Cystic fibrosis 39.14 10.26 35 112898 4696 110471670
Coronary artery disease 39.13 10.26 161 112772 71529 110404837
Product use in unapproved indication 38.94 10.26 282 112651 447095 110029271
Anaemia 38.86 10.26 779 112154 546307 109930059
Constipation 38.85 10.26 546 112387 357240 110119126
Pulmonary embolism 38.51 10.26 361 112572 214113 110262253
Mast cell activation syndrome 37.78 10.26 22 112911 1506 110474860
Respiration abnormal 37.24 10.26 48 112885 9761 110466605
Device failure 36.78 10.26 41 112892 7166 110469200
Blood creatinine increased 36.50 10.26 315 112618 182574 110293792
Bronchopulmonary aspergillosis allergic 36.41 10.26 44 112889 8382 110467984
Gait inability 36.07 10.26 52 112881 136324 110340042
Impaired gastric emptying 35.59 10.26 55 112878 13220 110463146
Onychomadesis 35.41 10.26 3 112930 45660 110430706
Fibromyalgia 35.39 10.26 76 112857 170833 110305533
Rales 35.21 10.26 78 112855 24661 110451705
Hyperglycaemic hyperosmolar nonketotic syndrome 34.75 10.26 27 112906 2982 110473384
Blood calcium increased 34.13 10.26 64 112869 17976 110458390
Wound infection 34.07 10.26 29 112904 96436 110379930
Adjustment disorder with depressed mood 33.71 10.26 3 112930 43880 110432486
Obesity 33.28 10.26 40 112893 113311 110363055
Dialysis 32.73 10.26 66 112867 19553 110456813
Paraesthesia 32.71 10.26 158 112775 276363 110200003
Injury 32.57 10.26 84 112849 177181 110299185
Type 2 diabetes mellitus 32.55 10.26 84 112849 177148 110299218
Febrile neutropenia 32.46 10.26 190 112743 316577 110159789
Chronic obstructive pulmonary disease 32.02 10.26 206 112727 108952 110367414
Arthritis 31.89 10.26 78 112855 167508 110308858
Sleep apnoea syndrome 31.53 10.26 102 112831 40345 110436021
Renal failure 31.48 10.26 362 112571 226212 110250154
Device malfunction 31.34 10.26 76 112857 25482 110450884
Prescribed overdose 31.33 10.26 26 112907 87555 110388811
Adverse event 31.31 10.26 39 112894 108770 110367596
Therapeutic drug monitoring analysis incorrectly performed 31.13 10.26 15 112918 697 110475669
Disease progression 30.90 10.26 136 112797 243898 110232468
Hypoxia 30.12 10.26 231 112702 129284 110347082
Sciatica 30.00 10.26 30 112903 92369 110383997
Polyuria 29.98 10.26 60 112873 17678 110458688
Lower respiratory tract infection 29.87 10.26 137 112796 242969 110233397
Tongue injury 29.72 10.26 14 112919 618 110475748
Polycystic ovaries 29.27 10.26 30 112903 4766 110471600
Product administration error 29.14 10.26 94 112839 37123 110439243
Knee arthroplasty 29.04 10.26 15 112918 64933 110411433
Foot deformity 28.82 10.26 7 112926 48473 110427893
Caesarean section 28.65 10.26 51 112882 13766 110462600
Onychomycosis 28.63 10.26 3 112930 38528 110437838
Drug resistance 28.37 10.26 11 112922 56363 110420003
Premature delivery 28.32 10.26 82 112851 30550 110445816
Lethargy 28.31 10.26 178 112755 93398 110382968
Dyslipidaemia 28.19 10.26 55 112878 15910 110460456
Adverse drug reaction 28.16 10.26 40 112893 105519 110370847
Pre-eclampsia 27.75 10.26 39 112894 8611 110467755
Injection site reaction 27.70 10.26 30 112903 89040 110387326
Laryngitis 27.52 10.26 5 112928 42406 110433960
Pregnancy 27.35 10.26 9 112924 51058 110425308
Total lung capacity decreased 27.30 10.26 35 112898 7079 110469287
Pancreatitis acute 27.29 10.26 128 112805 60146 110416220
Lymphoedema 27.05 10.26 52 112881 14877 110461489
Appetite disorder 26.93 10.26 41 112892 9728 110466638
Cellulitis 26.70 10.26 220 112713 125796 110350570
Hepatic encephalopathy 26.47 10.26 76 112857 28180 110448186
Prescribed underdose 26.36 10.26 17 112916 65157 110411209
Fatigue 26.15 10.26 997 111936 1214961 109261405
Coeliac disease 26.14 10.26 6 112927 43181 110433185
Taste disorder 25.19 10.26 18 112915 65369 110410997
Type 1 diabetes mellitus 24.98 10.26 38 112895 9009 110467357
Product dispensing error 24.93 10.26 53 112880 16292 110460074
Exostosis 24.78 10.26 8 112925 45948 110430418
Epilepsy 24.78 10.26 40 112893 100169 110376197
Bronchopneumopathy 24.58 10.26 14 112919 919 110475447
Tremor 24.56 10.26 315 112618 201917 110274449
Drug hypersensitivity 24.36 10.26 322 112611 453768 110022598
Immunodeficiency 24.31 10.26 5 112928 38833 110437533
Back injury 24.27 10.26 9 112924 47390 110428976
Fracture blisters 24.15 10.26 7 112926 74 110476292
Treatment noncompliance 24.08 10.26 142 112791 72848 110403518
Blindness transient 23.96 10.26 30 112903 5926 110470440
Exposure during pregnancy 23.93 10.26 269 112664 167155 110309211
Hepatocellular carcinoma 23.82 10.26 39 112894 9841 110466525
Polyhydramnios 23.76 10.26 18 112915 1915 110474451
Blood ketone body present 23.59 10.26 8 112925 146 110476220
Urosepsis 23.59 10.26 77 112856 30598 110445768
Hyperglycaemic unconsciousness 23.55 10.26 4 112929 0 110476366
Adenocarcinoma pancreas 23.34 10.26 19 112914 2244 110474122
Dermo-hypodermitis 23.19 10.26 16 112917 1472 110474894
Unresponsive to stimuli 22.95 10.26 127 112806 63663 110412703
Oedema peripheral 22.64 10.26 466 112467 328194 110148172
Coronavirus test positive 22.63 10.26 15 112918 1292 110475074
International normalised ratio abnormal 22.41 10.26 30 112903 6327 110470039
Pancreatitis 22.40 10.26 168 112765 93365 110383001
Lymphangitis 22.40 10.26 16 112917 1556 110474810
Blood pressure fluctuation 22.39 10.26 26 112907 74798 110401568
Diabetic gastroparesis 22.36 10.26 10 112923 391 110475975
Joint dislocation 22.25 10.26 4 112929 34186 110442180
Blood insulin increased 22.25 10.26 10 112923 396 110475970
Hypothermia 22.03 10.26 68 112865 26234 110450132
Road traffic accident 22.03 10.26 48 112885 107350 110369016
Abortion spontaneous 21.97 10.26 81 112852 34201 110442165
Hyperinsulinaemic hypoglycaemia 21.96 10.26 9 112924 283 110476083
Hepatocellular injury 21.80 10.26 106 112827 50536 110425830
Blood ketone body 21.79 10.26 8 112925 186 110476180
Hospitalisation 21.77 10.26 232 112701 142261 110334105
Rhabdomyolysis 21.77 10.26 203 112730 120198 110356168
Anti-insulin antibody increased 21.61 10.26 7 112926 110 110476256
Neutropenia 21.45 10.26 262 112671 374358 110102008
Suspected product tampering 21.32 10.26 4 112929 3 110476363
Medical device site abscess 21.17 10.26 8 112925 202 110476164
Product storage error 20.89 10.26 59 112874 21669 110454697
Hypernatraemia 20.78 10.26 52 112881 17781 110458585
Fear-related avoidance of activities 20.58 10.26 7 112926 129 110476237
Nightmare 20.55 10.26 7 112926 38856 110437510
Medical device site cellulitis 20.43 10.26 8 112925 223 110476143
Incorrect dose administered 20.40 10.26 178 112755 103463 110372903
Anti-insulin antibody 20.32 10.26 6 112927 68 110476298
Drug ineffective for unapproved indication 20.25 10.26 47 112886 102791 110373575
Benign prostatic hyperplasia 20.03 10.26 52 112881 18182 110458184
Nodule 19.99 10.26 76 112857 32555 110443811
Insomnia 19.96 10.26 254 112679 360336 110116030
Decreased insulin requirement 19.86 10.26 7 112926 144 110476222
Diabetic macroangiopathy 19.82 10.26 7 112926 145 110476221
Migraine 19.76 10.26 99 112834 171553 110304813
Weight increased 19.55 10.26 306 112627 419338 110057028
Mental status changes 19.53 10.26 139 112794 75983 110400383
Finger deformity 19.24 10.26 5 112928 33087 110443279
Gallbladder neoplasm 19.23 10.26 6 112927 83 110476283
Swelling 19.16 10.26 248 112685 350793 110125573
Haemorrhagic stroke 19.09 10.26 43 112890 13746 110462620
Depressive symptom 18.67 10.26 32 112901 8382 110467984
Memory impairment 18.67 10.26 121 112812 196823 110279543
Neck pain 18.54 10.26 64 112869 123066 110353300
Microalbuminuria 18.46 10.26 13 112920 1236 110475130
Insulin-requiring type 2 diabetes mellitus 18.37 10.26 7 112926 181 110476185
Diabetic retinal oedema 18.35 10.26 9 112924 435 110475931
Hepatotoxicity 17.95 10.26 23 112910 63377 110412989
Incorrect dose administered by device 17.94 10.26 28 112905 6786 110469580
Cerebrovascular accident 17.82 10.26 272 112661 181012 110295354
Erythema 17.77 10.26 201 112732 291246 110185120
Toe amputation 17.69 10.26 22 112911 4316 110472050
Hypervolaemia 17.48 10.26 98 112835 49362 110427004
Foot amputation 17.27 10.26 12 112921 1116 110475250
Device operational issue 17.24 10.26 12 112921 1120 110475246
Subgaleal haematoma 17.23 10.26 6 112927 119 110476247
Peritonitis bacterial 17.05 10.26 35 112898 10498 110465868
Ulcer 16.98 10.26 88 112845 43028 110433338
Microsporidia infection 16.81 10.26 13 112920 1426 110474940
Angina pectoris 16.72 10.26 115 112818 62180 110414186
Diabetic gangrene 16.68 10.26 7 112926 234 110476132
Oral herpes 16.63 10.26 8 112925 36072 110440294
Eye haemorrhage 16.62 10.26 37 112896 11737 110464629
Leg amputation 16.58 10.26 21 112912 4197 110472169
Glomerular filtration rate decreased 16.57 10.26 66 112867 28890 110447476
Campylobacter test positive 16.44 10.26 6 112927 137 110476229
Dizziness postural 16.39 10.26 42 112891 14567 110461799
Multiple lentigines syndrome 16.27 10.26 7 112926 249 110476117
Micturition urgency 16.23 10.26 50 112883 19270 110457096
Adverse reaction 16.23 10.26 5 112928 29589 110446777
Lack of application site rotation 16.10 10.26 5 112928 68 110476298
Haematochezia 16.10 10.26 62 112871 115462 110360904
Blood potassium increased 16.08 10.26 72 112861 33177 110443189
Acute myocardial infarction 16.03 10.26 143 112790 83634 110392732
Live birth 16.02 10.26 29 112904 69455 110406911
Pyrexia 16.00 10.26 752 112181 897513 109578853
Periodontitis 16.00 10.26 23 112910 5185 110471181
Pancreatic carcinoma 15.91 10.26 42 112891 14830 110461536
Disorientation 15.84 10.26 125 112808 70546 110405820
Multiple use of single-use product 15.78 10.26 12 112921 1284 110475082
Product container issue 15.74 10.26 13 112920 1567 110474799
Intentional product misuse 15.70 10.26 206 112727 132698 110343668
Suicide attempt 15.63 10.26 168 112765 103226 110373140
Hyperglycaemic seizure 15.59 10.26 3 112930 3 110476363
Neutrophil count decreased 15.54 10.26 67 112866 120874 110355492
Product complaint 15.51 10.26 40 112893 13932 110462434
Foetal hypokinesia 15.50 10.26 8 112925 431 110475935
Fall 15.47 10.26 759 112174 602723 109873643
Palpitations 15.30 10.26 238 112695 158974 110317392
Diabetic coma 15.21 10.26 12 112921 1356 110475010
Skin turgor decreased 15.20 10.26 10 112923 850 110475516
Lower limb fracture 15.18 10.26 34 112899 75314 110401052
Product gel formation 15.13 10.26 3 112930 4 110476362
Flank pain 15.11 10.26 55 112878 23075 110453291
Measles 14.86 10.26 9 112924 662 110475704
Blood pressure diastolic abnormal 14.82 10.26 4 112929 25811 110450555
Conjunctivitis 14.82 10.26 8 112925 33784 110442582
Transient ischaemic attack 14.80 10.26 114 112819 63868 110412498
Diabetic complication 14.80 10.26 12 112921 1410 110474956
Diabetic hyperosmolar coma 14.77 10.26 10 112923 892 110475474
Lupus-like syndrome 14.73 10.26 12 112921 40780 110435586
Therapeutic response decreased 14.63 10.26 50 112883 96449 110379917
Peripheral swelling 14.60 10.26 308 112625 403726 110072640
Renal impairment 14.59 10.26 272 112661 188173 110288193
Abscess 14.44 10.26 61 112872 27408 110448958
Product contamination with body fluid 14.37 10.26 3 112930 6 110476360
Intentional overdose 14.27 10.26 202 112731 132299 110344067
Cardiac failure 14.24 10.26 270 112663 187356 110289010
Underdose 14.23 10.26 27 112906 63527 110412839
Syncope 14.21 10.26 288 112645 202248 110274118
Fluid retention 14.15 10.26 153 112780 94154 110382212
Metabolic acidosis 14.13 10.26 160 112773 99584 110376782
Poisoning 14.12 10.26 6 112927 29099 110447267
White blood cell count decreased 14.06 10.26 158 112775 229232 110247134
Acute myeloid leukaemia 14.02 10.26 11 112922 38099 110438267
Vision blurred 14.02 10.26 197 112736 128825 110347541
Aspiration 13.94 10.26 65 112868 30468 110445898
Heart rate decreased 13.86 10.26 41 112892 82715 110393651
Joint stiffness 13.83 10.26 30 112903 67213 110409153
Lymphangiectasia 13.83 10.26 5 112928 111 110476255
Hypercholesterolaemia 13.82 10.26 47 112886 90790 110385576
Amnesia 13.79 10.26 58 112875 105350 110371016
Mucosal inflammation 13.79 10.26 51 112882 96090 110380276
Malignant neoplasm progression 13.77 10.26 113 112820 174454 110301912
Ear infection 13.74 10.26 27 112906 62705 110413661
Wrong technique in device usage process 13.71 10.26 25 112908 6876 110469490
Amniorrhexis 13.66 10.26 4 112929 44 110476322
Drug reaction with eosinophilia and systemic symptoms 13.52 10.26 41 112892 82054 110394312
Hypertransaminasaemia 13.48 10.26 4 112929 24251 110452115
Anaphylactic reaction 13.43 10.26 177 112756 114123 110362243
Peripheral artery haematoma 13.43 10.26 5 112928 121 110476245
Osteoporosis 13.32 10.26 45 112888 87107 110389259
Dry gangrene 13.28 10.26 10 112923 1054 110475312
Basal cell carcinoma 13.26 10.26 16 112917 45254 110431112
Suspected product quality issue 13.18 10.26 8 112925 591 110475775
Gingival hypertrophy 13.12 10.26 19 112914 4312 110472054
Generalised oedema 13.03 10.26 64 112869 30640 110445726
Sputum increased 12.93 10.26 22 112911 5729 110470637
Pleuritic pain 12.85 10.26 41 112892 16099 110460267
Thirst 12.84 10.26 50 112883 21657 110454709
Sedation 12.81 10.26 33 112900 69650 110406716
Lipoatrophy 12.76 10.26 8 112925 626 110475740
Hepatic cytolysis 12.69 10.26 98 112835 54955 110421411
Mesenteric arterial occlusion 12.67 10.26 6 112927 268 110476098
Haematotoxicity 12.62 10.26 3 112930 21079 110455287
Device expulsion 12.57 10.26 8 112925 30883 110445483
Lung opacity 12.56 10.26 33 112900 11619 110464747
Cholestatic liver injury 12.53 10.26 25 112908 7351 110469015
Colitis ulcerative 12.48 10.26 39 112894 77324 110399042
Threatened labour 12.38 10.26 8 112925 660 110475706
Drug clearance decreased 12.37 10.26 18 112915 4104 110472262
Progressive multifocal leukoencephalopathy 12.34 10.26 5 112928 24951 110451415
Dialysis device insertion 12.34 10.26 4 112929 63 110476303
Hypokalaemia 12.32 10.26 258 112675 182190 110294176
Blood pressure systolic abnormal 12.26 10.26 5 112928 24845 110451521
Renal artery stenosis 12.25 10.26 17 112916 3709 110472657
Respiratory disorder 12.22 10.26 35 112898 71347 110405019
Subdural haemorrhage 12.08 10.26 23 112910 6535 110469831
Respiratory arrest 12 10.26 26 112907 58273 110418093
Feeling hot 12.00 10.26 50 112883 91056 110385310
Nonreassuring foetal heart rate pattern 11.99 10.26 3 112930 17 110476349
Postprandial hypoglycaemia 11.98 10.26 5 112928 165 110476201
Injection site atrophy 11.85 10.26 7 112926 492 110475874
Glucose-6-phosphate dehydrogenase deficiency 11.82 10.26 7 112926 494 110475872
Aplastic anaemia 11.81 10.26 5 112928 24303 110452063
Osteitis 11.80 10.26 18 112915 4278 110472088
Medical device site infection 11.74 10.26 8 112925 721 110475645
Product odour abnormal 11.71 10.26 11 112922 1572 110474794
Metabolic encephalopathy 11.60 10.26 31 112902 11029 110465337
Expired product administered 11.58 10.26 26 112907 8294 110468072
Neoplasm progression 11.56 10.26 31 112902 64564 110411802
Cardiovascular disorder 11.55 10.26 50 112883 22710 110453656
Fine motor skill dysfunction 11.55 10.26 22 112911 6252 110470114
Blood insulin decreased 11.45 10.26 3 112930 21 110476345
Cerebral infarction 11.24 10.26 91 112842 51747 110424619
Intraductal papillary-mucinous carcinoma of pancreas 11.21 10.26 3 112930 23 110476343
Intentional self-injury 11.21 10.26 13 112920 37416 110438950
Carcinoid crisis 11.16 10.26 7 112926 548 110475818
Refraction disorder 11.10 10.26 4 112929 88 110476278
Inability to afford medication 11.08 10.26 17 112916 4059 110472307
Acetonaemia 11.05 10.26 7 112926 558 110475808
Cardiac failure congestive 11.02 10.26 216 112717 150784 110325582
Septic necrosis 10.93 10.26 4 112929 92 110476274
Pharyngeal swelling 10.92 10.26 32 112901 12000 110464366
Diabetic hyperglycaemic coma 10.89 10.26 4 112929 93 110476273
Polymorphic light eruption 10.88 10.26 3 112930 26 110476340
Hot flush 10.86 10.26 33 112900 66003 110410363
Neisseria infection 10.85 10.26 5 112928 210 110476156
Injection site hypersensitivity 10.84 10.26 13 112920 2458 110473908
Pancreatic carcinoma metastatic 10.81 10.26 17 112916 4147 110472219
Large intestine polyp 10.78 10.26 37 112896 15080 110461286
Cholestasis 10.78 10.26 107 112826 64411 110411955
Hunger 10.76 10.26 22 112911 6582 110469784
Hypophagia 10.68 10.26 91 112842 52535 110423831
Foetal macrosomia 10.66 10.26 4 112929 99 110476267
Device delivery system issue 10.66 10.26 12 112921 2121 110474245
High risk pregnancy 10.62 10.26 4 112929 100 110476266
Cystic fibrosis related diabetes 10.59 10.26 5 112928 222 110476144
Swollen tongue 10.52 10.26 101 112832 60261 110416105
Injection site hypertrophy 10.51 10.26 4 112929 103 110476263
Psoriasis 10.42 10.26 92 112841 139901 110336465
Urine ketone body present 10.40 10.26 16 112917 3830 110472536
Retrograde ejaculation 10.38 10.26 6 112927 405 110475961
Diabetic foot infection 10.36 10.26 8 112925 876 110475490
Acute painful neuropathy of rapid glycaemic control 10.33 10.26 3 112930 32 110476334
Respiratory tract infection 10.26 10.26 38 112895 71579 110404787

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10AB05 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
INSULINS AND ANALOGUES
Insulins and analogues for injection, fast-acting
ATC A10AD05 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
INSULINS AND ANALOGUES
Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
ATC A10AD06 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
INSULINS AND ANALOGUES
Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
FDA CS M0011417 Insulin
FDA EPC N0000175453 Insulin Analog
FDA EPC N0000175944 Insulin
MeSH PA D007004 Hypoglycemic Agents
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35821 anticholesteremic drug
CHEBI has role CHEBI:39456 antiglaucoma drug
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:50864 insulin-sensitizing drug
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:76916 hyperglycemic agent
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

A10AB Insulins and analogues for injection, fast-acting 5 drugs
insulin beefinsulin glulisineinsulin humaninsulin lisproinsulin pork
A10AD Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting 5 drugs
insulin beefinsulin degludecinsulin humaninsulin lisproinsulin pork

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus indication 73211009 DOID:9351




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Insulin receptor Kinase AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
D04475 KEGG_DRUG
4021226 VUID
N0000148670 NUI
4017559 VANDF
4017569 VANDF
4019786 VANDF
4021226 VANDF
4021394 VANDF
CHEBI:749465 CHEBI
CHEMBL1201496 ChEMBL_ID
CHEMBL1201664 ChEMBL_ID
DB01306 DRUGBANK_ID
253182 RXNORM
15636 MMSL
17095 MMSL
327602 MMSL
37703 MMSL
4885 MMSL
4886 MMSL
d00262 MMSL
d04369 MMSL
d04697 MMSL
d04838 MMSL
000869 NDDF
000870 NDDF
006518 NDDF
007992 NDDF
009607 NDDF
126210001 SNOMEDCT_US
325072002 SNOMEDCT_US
388452006 SNOMEDCT_US
417423002 SNOMEDCT_US
420609005 SNOMEDCT_US
427292001 SNOMEDCT_US
96367001 SNOMEDCT_US
C0123677 UMLSCUI
D061267 MESH_DESCRIPTOR_UI
C0795635 UMLSCUI
DB00030 DRUGBANK_ID
7541 INN_ID
16132418 PUBCHEM_CID
118984375 PUBCHEM_CID
D933668QVX UNII
5186 INN_ID
CHEBI:5931 CHEBI
D933668QVX INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
MERILOG HUMAN PRESCRIPTION DRUG LABEL 1 0024-5927 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 34 sections
MERILOG HUMAN PRESCRIPTION DRUG LABEL 1 0024-5928 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 34 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 0169-2100 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 28 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 0169-2101 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 28 sections
NovoLog Mix 70/30 HUMAN PRESCRIPTION DRUG LABEL 1 0169-2200 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 26 sections
NovoLog Mix 70/30 HUMAN PRESCRIPTION DRUG LABEL 1 0169-2201 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 26 sections
Fiasp HUMAN PRESCRIPTION DRUG LABEL 1 0169-3201 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 26 sections
Fiasp HUMAN PRESCRIPTION DRUG LABEL 1 0169-3204 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 26 sections
Fiasp HUMAN PRESCRIPTION DRUG LABEL 1 0169-3205 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 26 sections
Fiasp HUMAN PRESCRIPTION DRUG LABEL 1 0169-3206 INJECTION, SOLUTION 100 [iU] SUBCUTANEOUS BLA 26 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 0169-3303 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 28 sections
NovoLog Mix 70/30 HUMAN PRESCRIPTION DRUG LABEL 1 0169-3685 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 26 sections
NovoLog Mix 70/30 HUMAN PRESCRIPTION DRUG LABEL 1 0169-3696 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 26 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 0169-6338 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 28 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 0169-6339 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 28 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 0169-7501 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 28 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 50090-1664 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 27 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 50090-1665 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 27 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 50090-1678 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 27 sections
NovoLog Mix 70/30 HUMAN PRESCRIPTION DRUG LABEL 1 50090-2272 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 26 sections
NOVOLOG MIX 70/30 HUMAN PRESCRIPTION DRUG LABEL 1 50090-2273 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 26 sections
NOVOLOG HUMAN PRESCRIPTION DRUG LABEL 1 50090-4500 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 27 sections
Insulin Aspart HUMAN PRESCRIPTION DRUG LABEL 1 50090-4955 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 27 sections
Insulin Aspart HUMAN PRESCRIPTION DRUG LABEL 1 50090-4956 INJECTION, SOLUTION 100 [iU] INTRAVENOUS BLA 27 sections
.Insulin Aspart Protamine and Insulin Aspart HUMAN PRESCRIPTION DRUG LABEL 1 50090-4959 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 26 sections
NovoLog Mix 70/30 HUMAN PRESCRIPTION DRUG LABEL 1 54868-5201 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS NDA 31 sections
NovoLog Mix 70/30 HUMAN PRESCRIPTION DRUG LABEL 1 54868-5327 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS NDA 31 sections
NovoLog HUMAN PRESCRIPTION DRUG LABEL 1 64725-0750 INJECTION, SOLUTION 100 [iU] INTRAVENOUS NDA 28 sections
NovoLog HUMAN PRESCRIPTION DRUG LABEL 1 68258-8899 INJECTION, SOLUTION 100 [iU] INTRAVENOUS NDA 29 sections
NovoLog Mix 70/30 HUMAN PRESCRIPTION DRUG LABEL 1 70518-2119 INJECTION, SUSPENSION 100 [iU] SUBCUTANEOUS BLA 26 sections