infliximab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
chimeric origin 4974 170277-31-3

Description:

MoleculeDescription

Synonyms:

  • INFLIXIMAB-QBTX
  • inflectra
  • infliximab
  • remicade
  • infliximab-dyyb
Infliximab products neutralize the biological activity of TNF-alpha by binding with high affinity to the soluble and transmembrane forms of TNF-alpha and inhibit binding of TNF-alpha with its receptors. Infliximab products do not neutralize TNF-beta (lymphotoxin-alpha), a related cytokine that utilizes the same receptors as TNF-alpha. Biological activities attributed to TNF-alpha include: induction of pro-inflammatory cytokines such as interleukins (IL) 1 and 6, enhancement of leukocyte migration by increasing endothelial layer permeability and expression of adhesion molecules by endothelial cells and leukocytes, activation of neutrophil and eosinophil functional activity, induction of acute phase reactants and other liver proteins, as well as tissue degrading enzymes produced by synoviocytes and/or chondrocytes. Cells expressing transmembrane TNF-alpha bound by infliximab products can be lysed in vitro or in vivo. Infliximab products inhibit the functional activity of TNF-alpha in a wide variety of in vitro bioassays utilizing human fibroblasts, endothelial cells, neutrophils, B and T-lymphocytes and epithelial cells. The relationship of these biological response markers to the mechanism(s) by which infliximab products exert their clinical effects is unknown. Anti-TNF-alpha antibodies reduce disease activity in the cotton-top tamarin colitis model, and decrease synovitis and joint erosions in a murine model of collagen-induced arthritis. Infliximab products prevent disease in transgenic mice that develop polyarthritis as a result of constitutive expression of human TNF-alpha, and when administered after disease onset, allow eroded joints to heal.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3.75 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 13, 1999 EMA
Aug. 24, 1998 FDA CENTOCOR INC
Jan. 17, 2002 PMDA Tanabe Seiyaku

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Infusion related reaction 5425.41 11.99 8106 496605 237415 62746896
Off label use 4304.54 11.99 13404 491307 661058 62323253
Intentional product use issue 3239.09 11.99 4511 500200 123381 62860930
Product use issue 3191.95 11.99 6031 498680 214489 62769822
Drug ineffective 2875.05 11.99 16028 488683 1028737 61955574
Condition aggravated 2488.99 11.99 7926 496785 394291 62590020
Systemic lupus erythematosus 2238.27 11.99 5050 499661 203868 62780443
Contraindicated product administered 2144.83 11.99 5091 499620 212557 62771754
Inappropriate schedule of product administration 1907.25 11.99 3158 501553 100807 62883504
Drug intolerance 1883.74 11.99 6058 498653 302603 62681708
Lupus-like syndrome 1844.23 11.99 1275 503436 14020 62970291
Pemphigus 1825.87 11.99 4313 500398 179413 62804898
Treatment failure 1742.92 11.99 4451 500260 194592 62789719
Toxicity to various agents 1649.13 11.99 75 504636 247175 62737136
Synovitis 1591.94 11.99 4137 500574 182781 62801530
Alopecia 1525.84 11.99 6004 498707 331532 62652779
Arthropathy 1511.23 11.99 4696 500015 230096 62754215
Glossodynia 1484.24 11.99 3921 500790 174955 62809356
Death 1427.35 11.99 596 504115 373785 62610526
Hand deformity 1321.15 11.99 3494 501217 155963 62828348
Acute kidney injury 1305.47 11.99 255 504456 263160 62721151
Therapeutic product effect decreased 1177.21 11.99 3793 500918 189394 62794917
Drug interaction 1173.48 11.99 204 504507 228927 62755384
Abdominal discomfort 1104.07 11.99 5259 499452 315626 62668685
Completed suicide 1054.11 11.99 21 504690 145652 62838659
Wound 1022.97 11.99 3237 501474 160026 62824285
Anti-cyclic citrullinated peptide antibody positive 940.17 11.99 2525 502186 113687 62870624
Pericarditis 893.90 11.99 2684 502027 128895 62855416
Joint swelling 887.41 11.99 5025 499686 322641 62661670
Fall 846.60 11.99 1129 503582 391205 62593106
Drug level below therapeutic 800.63 11.99 493 504218 4373 62979938
Neutropenia 763.15 11.99 222 504489 174783 62809528
Swelling 760.86 11.99 4247 500464 271131 62713180
Discomfort 760.17 11.99 2985 501726 164389 62819922
Anaemia 758.31 11.99 729 503982 292701 62691610
Arthralgia 754.70 11.99 7368 497343 562342 62421969
Intestinal resection 742.87 11.99 390 504321 2458 62981853
Blood pressure fluctuation 738.26 11.99 1323 503388 44994 62939317
Febrile neutropenia 736.91 11.99 53 504658 118396 62865915
Hepatic enzyme increased 724.53 11.99 3357 501354 198971 62785340
Rheumatoid factor positive 704.72 11.99 1856 502855 82550 62901761
Drug specific antibody present 676.65 11.99 422 504289 3837 62980474
Fistula 648.81 11.99 588 504123 9805 62974506
Hyponatraemia 639.73 11.99 71 504640 111829 62872482
Tuberculosis 629.72 11.99 598 504113 10613 62973698
Maternal exposure during pregnancy 627.53 11.99 3424 501287 216638 62767673
Haematochezia 608.33 11.99 1327 503384 52217 62932094
Frequent bowel movements 585.71 11.99 815 503896 22207 62962104
Disease progression 572.56 11.99 136 504575 122622 62861689
Product dose omission issue 569.95 11.99 613 504098 233700 62750611
Hypersensitivity 568.67 11.99 4128 500583 288557 62695754
Skin cancer 566.89 11.99 571 504140 10924 62973387
Hypotension 566.74 11.99 805 503906 271799 62712512
Transplant dysfunction 542.65 11.99 387 504324 4485 62979826
Injection site pain 533.05 11.99 183 504528 129617 62854694
Drug abuse 526.26 11.99 10 504701 72508 62911803
Helicobacter infection 523.27 11.99 1776 502935 91009 62893302
Duodenal ulcer perforation 517.31 11.99 1698 503013 85511 62898800
Intentional overdose 516.10 11.99 16 504695 74136 62910175
Malignant neoplasm progression 515.80 11.99 35 504676 82086 62902225
Somnolence 502.02 11.99 410 504301 178275 62806036
Basal cell carcinoma 490.79 11.99 834 503877 27157 62957154
White blood cell count decreased 489.31 11.99 247 504464 138857 62845454
Faecal calprotectin increased 487.85 11.99 309 504402 2894 62981417
Asthenia 481.94 11.99 1508 503203 382096 62602215
Anal fissure 478.98 11.99 346 504365 4097 62980214
Drug level decreased 478.63 11.99 440 504271 7479 62976832
Platelet count decreased 478.05 11.99 163 504548 115959 62868352
Exposure during pregnancy 471.51 11.99 2462 502249 153085 62831226
Pulmonary tuberculosis 469.33 11.99 344 504367 4173 62980138
Therapeutic response shortened 459.67 11.99 519 504192 11369 62972942
Cardiac arrest 450.76 11.99 93 504618 92452 62891859
Neuropathy peripheral 448.47 11.99 171 504540 113496 62870815
Electrocardiogram QT prolonged 445.71 11.99 5 504706 59525 62924786
Disseminated tuberculosis 430.22 11.99 274 504437 2593 62981718
Constipation 428.18 11.99 705 504006 224238 62760073
Red blood cell sedimentation rate increased 420.01 11.99 1018 503693 42964 62941347
Seizure 418.54 11.99 269 504442 132365 62851946
Thrombocytopenia 414.49 11.99 355 504356 150802 62833509
Rheumatoid arthritis 408.01 11.99 3427 501284 250392 62733919
Breast cancer 401.69 11.99 1062 503649 47321 62936990
Injection site erythema 394.04 11.99 89 504622 83085 62901226
Diarrhoea 391.83 11.99 3720 500991 711646 62272665
Atrial fibrillation 374.27 11.99 232 504479 116404 62867907
Uveitis 373.87 11.99 480 504231 12073 62972238
Balance disorder 371.66 11.99 105 504606 84317 62899994
Cardiac failure 368.84 11.99 124 504587 89018 62895293
Loss of personal independence in daily activities 368.35 11.99 1642 503069 95648 62888663
Anal fistula 365.71 11.99 269 504442 3282 62981029
Hyperkalaemia 365.70 11.99 15 504696 54188 62930123
Colectomy 363.80 11.99 238 504473 2368 62981943
C-reactive protein abnormal 363.74 11.99 993 503718 45103 62939208
Pancytopenia 357.86 11.99 161 504550 96772 62887539
Overdose 355.47 11.99 239 504472 114839 62869472
Poor venous access 351.81 11.99 507 504204 14278 62970033
Therapeutic product effect incomplete 350.70 11.99 1938 502773 123118 62861193
Psoriasis 347.76 11.99 1492 503219 85465 62898846
Hypokalaemia 344.97 11.99 198 504513 103606 62880705
Psoriatic arthropathy 343.74 11.99 1541 503170 89979 62894332
Pain 342.93 11.99 7994 496717 732634 62251677
Dehydration 332.87 11.99 540 504171 172814 62811497
Ovarian cyst 329.69 11.99 512 504199 15433 62968878
Coma 327.59 11.99 58 504653 64306 62920005
Musculoskeletal stiffness 326.42 11.99 2548 502163 182070 62802241
Hallucination 317.77 11.99 33 504678 54784 62929527
Bradycardia 315.14 11.99 95 504616 73132 62911179
Hypoglycaemia 312.60 11.99 51 504660 60014 62924297
Neutrophil count decreased 309.49 11.99 41 504670 56365 62927946
Oedema peripheral 307.52 11.99 654 504057 188857 62795454
Blood iron abnormal 304.25 11.99 250 504461 3626 62980685
Cardio-respiratory arrest 303.06 11.99 55 504656 59904 62924407
Insomnia 300.70 11.99 804 503907 214448 62769863
Transplant rejection 300.52 11.99 399 504312 10381 62973930
Intestinal stenosis 300.46 11.99 220 504491 2664 62981647
Dizziness 299.62 11.99 2094 502617 427831 62556480
Agitation 297.36 11.99 57 504654 59700 62924611
Renal failure 296.85 11.99 298 504413 117354 62866957
Blood glucose increased 295.53 11.99 148 504563 83608 62900703
Cardiac failure congestive 293.57 11.99 186 504525 92247 62892064
Sleep disorder due to general medical condition, insomnia type 292.03 11.99 997 503714 51220 62933091
Suicide attempt 286.91 11.99 66 504645 60852 62923459
Gastrointestinal haemorrhage 285.58 11.99 144 504567 81032 62903279
Blood creatinine increased 281.41 11.99 175 504536 87669 62896642
Acne 281.38 11.99 592 504119 22701 62961610
Rheumatic fever 279.76 11.99 866 503845 42245 62942066
Depressed level of consciousness 279.26 11.99 74 504637 62004 62922307
Cognitive disorder 274.03 11.99 55 504656 55760 62928551
Sedation 271.39 11.99 8 504703 38801 62945510
Pyoderma gangrenosum 266.26 11.99 225 504486 3400 62980911
Rhabdomyolysis 258.56 11.99 25 504686 43926 62940385
Knee arthroplasty 255.60 11.99 979 503732 53227 62931084
Inflammation 253.03 11.99 1308 503403 80965 62903346
Epistaxis 249.89 11.99 133 504578 72592 62911719
Hyperglycaemia 248.46 11.99 23 504688 41844 62942467
Flushing 247.97 11.99 1218 503493 73869 62910442
International normalised ratio increased 247.07 11.99 37 504674 46388 62937923
Tremor 246.30 11.99 420 504291 131819 62852492
Urinary tract infection 245.39 11.99 1175 503536 263509 62720802
Metabolic acidosis 244.32 11.99 34 504677 45035 62939276
Hip arthroplasty 243.40 11.99 883 503828 46763 62937548
Dyspnoea exertional 240.66 11.99 89 504622 60213 62924098
Gastrooesophageal reflux disease 240.38 11.99 243 504468 95396 62888915
C-reactive protein increased 239.43 11.99 1428 503283 93279 62891032
Drug specific antibody 239.38 11.99 177 504534 2178 62982133
Anal abscess 239.29 11.99 236 504475 4396 62979915
Wrong technique in product usage process 237.28 11.99 99 504612 62241 62922070
Mucosal inflammation 237.26 11.99 43 504668 46885 62937426
Neoplasm progression 236.32 11.99 13 504698 36415 62947896
Mucous stools 231.74 11.99 223 504488 4025 62980286
Drug level above therapeutic 230.19 11.99 235 504476 4570 62979741
Decreased appetite 228.92 11.99 1121 503590 249931 62734380
Pulmonary embolism 226.23 11.99 361 504350 116323 62867988
Folliculitis 223.95 11.99 1129 503582 69188 62915123
Abscess 223.08 11.99 442 504269 16226 62968085
Rash 220.76 11.99 5926 498785 554945 62429366
Haemoglobin decreased 220.48 11.99 521 504190 144964 62839347
Bone pain 217.46 11.99 81 504630 54560 62929751
Lactic acidosis 214.48 11.99 26 504685 38261 62946050
Swollen joint count increased 213.63 11.99 702 504009 35352 62948959
Nausea 212.67 11.99 5175 499536 849296 62135015
Hypoxia 211.90 11.99 105 504606 59687 62924624
Memory impairment 209.33 11.99 315 504396 103943 62880368
Anxiety 204.33 11.99 961 503750 216580 62767731
Histoplasmosis disseminated 203.31 11.99 133 504578 1323 62982988
Pulmonary oedema 202.71 11.99 91 504620 54782 62929529
Injection site swelling 202.37 11.99 63 504648 47509 62936802
Vision blurred 202.29 11.99 260 504451 91664 62892647
Blood bilirubin increased 199.02 11.99 29 504682 37111 62947200
Red blood cell sedimentation rate abnormal 198.65 11.99 467 504244 19315 62964996
Therapy interrupted 197.58 11.99 16 504695 32439 62951872
Cerebrovascular accident 197.57 11.99 347 504364 107677 62876634
Arthritis 196.52 11.99 1585 503126 114336 62869975
Intentional product misuse 192.83 11.99 123 504588 60794 62923517
Infection 189.97 11.99 2713 501998 226460 62757851
Drug reaction with eosinophilia and systemic symptoms 189.48 11.99 23 504688 33813 62950498
Respiratory failure 188.28 11.99 325 504386 101533 62882778
Dysarthria 188.18 11.99 53 504658 42658 62941653
Depression 188.07 11.99 862 503849 195630 62788681
Adverse event 187.93 11.99 1045 503666 66514 62917797
Full blood count decreased 187.14 11.99 4 504707 26020 62958291
Drug hypersensitivity 186.50 11.99 3487 501224 307200 62677111
Orthostatic hypotension 185.27 11.99 32 504679 36128 62948183
Pulmonary hypertension 183.44 11.99 36 504675 37087 62947224
Injection site pruritus 182.72 11.99 65 504646 45051 62939260
Hypervolaemia 181.67 11.99 11 504700 28402 62955909
Weight increased 179.66 11.99 2992 501719 257800 62726511
Muscle injury 178.60 11.99 1006 503705 64339 62919972
Mental status changes 178.48 11.99 47 504664 39552 62944759
Dysphagia 177.49 11.99 268 504443 88317 62895994
Irritable bowel syndrome 177.48 11.99 1193 503518 81219 62903092
Herpes zoster 177.16 11.99 1193 503518 81269 62903042
Full blood count abnormal 176.53 11.99 22 504689 31695 62952616
Feeling abnormal 175.04 11.99 599 504112 147793 62836518
Product quality issue 174.68 11.99 36 504675 35829 62948482
Granuloma skin 174.53 11.99 271 504440 8166 62976145
Encephalopathy 173.76 11.99 46 504665 38574 62945737
Disorientation 173.73 11.99 49 504662 39403 62944908
Hypomagnesaemia 172.64 11.99 15 504696 28722 62955589
Drug withdrawal syndrome 172.46 11.99 11 504700 27183 62957128
Irritability 171.58 11.99 24 504687 31670 62952641
Blood parathyroid hormone decreased 169.32 11.99 290 504421 9501 62974810
Plasma cell myeloma 168.86 11.99 39 504672 35866 62948445
Injection site bruising 168.68 11.99 61 504650 41849 62942462
Dysgeusia 168.61 11.99 80 504631 46630 62937681
Intentional self-injury 167.14 11.99 9 504702 25678 62958633
Suicidal ideation 166.88 11.99 150 504561 62271 62922040
Panniculitis 165.92 11.99 313 504398 11072 62973239
Ileostomy 165.69 11.99 118 504593 1364 62982947
Deep vein thrombosis 165.51 11.99 256 504455 83544 62900767
Erythema nodosum 165.36 11.99 199 504512 4676 62979635
Drug tolerance decreased 163.11 11.99 401 504310 17072 62967239
Unresponsive to stimuli 162.52 11.99 35 504676 33781 62950530
Sopor 161.01 11.99 3 504708 22161 62962150
Therapy cessation 160.40 11.99 25 504686 30432 62953879
Disturbance in attention 159.90 11.99 52 504659 38137 62946174
Hypothyroidism 158.57 11.99 70 504641 42562 62941749
Blood calcium decreased 158.38 11.99 14 504697 26437 62957874
Incorrect dose administered 157.83 11.99 914 503797 59054 62925257
Fluid retention 156.51 11.99 146 504565 59540 62924771
Palmar-plantar erythrodysaesthesia syndrome 156.49 11.99 6 504705 23009 62961302
Demyelination 152.64 11.99 229 504482 6691 62977620
Body temperature fluctuation 151.96 11.99 134 504577 2151 62982160
Therapeutic response decreased 151.18 11.99 921 503790 60604 62923707
Clostridium difficile infection 150.66 11.99 552 504159 29370 62954941
Urinary retention 150.53 11.99 29 504682 30272 62954039
Peritoneal tuberculosis 149.86 11.99 75 504636 421 62983890
Dry skin 148.17 11.99 140 504571 56747 62927564
Lymphoma 147.48 11.99 310 504401 11877 62972434
Pulmonary arterial hypertension 146.62 11.99 8 504703 22569 62961742
Muscular weakness 146.25 11.99 491 504220 121862 62862449
Bone erosion 145.08 11.99 387 504324 17330 62966981
Dyspnoea 144.04 11.99 4081 500630 657232 62327079
Respiratory arrest 142.91 11.99 41 504670 32604 62951707
Acute respiratory failure 142.56 11.99 48 504663 34437 62949874
Heart rate irregular 142.30 11.99 447 504264 21974 62962337
Device dislocation 140.25 11.99 19 504692 25686 62958625
Lethargy 139.91 11.99 143 504568 55864 62928447
Osteonecrosis of jaw 139.87 11.99 52 504659 35071 62949240
Haematoma 139.59 11.99 51 504660 34769 62949542
Agranulocytosis 138.51 11.99 18 504693 25116 62959195
Altered state of consciousness 136.82 11.99 19 504692 25211 62959100
Dyskinesia 136.80 11.99 42 504669 31960 62952351
Pulmonary fibrosis 135.86 11.99 652 504059 39157 62945154
Polyarthritis 135.71 11.99 269 504442 9877 62974434
Back pain 135.65 11.99 1393 503318 262752 62721559
Mobility decreased 135.59 11.99 1517 503194 119642 62864669
Type 2 diabetes mellitus 135.37 11.99 921 503790 62947 62921364
Rheumatoid nodule 134.73 11.99 369 504342 16786 62967525
Hypophagia 133.66 11.99 41 504670 31218 62953093
Exposure to SARS-CoV-2 133.39 11.99 111 504600 1640 62982671
Renal impairment 132.54 11.99 318 504393 88037 62896274
Blood creatine phosphokinase increased 131.77 11.99 39 504672 30391 62953920
Cough 131.67 11.99 1591 503120 291152 62693159
Myocardial infarction 131.27 11.99 384 504327 99509 62884802
Device issue 131.13 11.99 17 504694 23764 62960547
Toxic epidermal necrolysis 130.71 11.99 22 504689 25312 62958999
Lymphocyte count decreased 130.62 11.99 39 504672 30218 62954093
Ascites 130.60 11.99 81 504630 40647 62943664
Asthma 130.25 11.99 546 504165 127015 62857296
Serum sickness 130.01 11.99 136 504575 2724 62981587
Pneumonia aspiration 129.59 11.99 56 504655 34484 62949827
Heart rate decreased 129.54 11.99 709 504002 44851 62939460
Melaena 129.53 11.99 40 504671 30325 62953986
Blood potassium decreased 128.75 11.99 88 504623 41938 62942373
Vomiting 128.03 11.99 3429 501282 556188 62428123
Cardiac disorder 127.79 11.99 129 504582 50687 62933624
Colitis ulcerative 126.90 11.99 476 504235 25615 62958696
Multiple organ dysfunction syndrome 126.42 11.99 159 504552 56593 62927718
Aphasia 126.22 11.99 52 504659 32948 62951363
Blood urea increased 125.36 11.99 28 504683 26351 62957960
Chronic obstructive pulmonary disease 125.22 11.99 190 504521 62496 62921815
Withdrawal syndrome 124.15 11.99 9 504702 19988 62964323
Cerebral haemorrhage 123.20 11.99 45 504666 30684 62953627
Aggression 122.14 11.99 20 504691 23478 62960833
Blood cholesterol increased 121.46 11.99 1212 503499 92820 62891491
Muscle spasms 121.39 11.99 735 503976 155415 62828896
Liver injury 120.77 11.99 860 503851 59660 62924651
Neurotoxicity 120.66 11.99 3 504708 16987 62967324
Impaired healing 120.28 11.99 1296 503415 101246 62883065
Cholestasis 119.89 11.99 42 504669 29392 62954919
Sepsis 119.43 11.99 720 503991 152403 62831908
Malignant melanoma 118.31 11.99 272 504439 11084 62973227
Histoplasmosis 118.10 11.99 109 504602 1862 62982449
Hepatic function abnormal 117.53 11.99 75 504636 37067 62947244
Pneumocystis jirovecii pneumonia 116.48 11.99 347 504364 16567 62967744
Syncope 115.21 11.99 510 504201 116875 62867436
Pustular psoriasis 115.00 11.99 162 504549 4464 62979847
Muscle spasticity 114.52 11.99 18 504693 21776 62962535
Joint destruction 114.51 11.99 190 504521 6062 62978249
Ill-defined disorder 114.06 11.99 1071 503640 80684 62903627
Hallucination, visual 113.44 11.99 11 504700 19287 62965024
Vascular access complication 113.30 11.99 110 504601 2008 62982303
Hodgkin's disease 113.21 11.99 74 504637 735 62983576
Upper gastrointestinal haemorrhage 112.81 11.99 10 504701 18842 62965469
Blood alkaline phosphatase increased 112.77 11.99 105 504606 42862 62941449
Tenosynovitis 111.61 11.99 300 504411 13495 62970816
Musculoskeletal deformity 111.35 11.99 104 504607 1805 62982506
Sinusitis bacterial 111.24 11.99 92 504619 1347 62982964
Injection site haemorrhage 111.22 11.99 28 504683 24286 62960025
Enthesopathy 111.16 11.99 225 504486 8389 62975922
Blister 111.13 11.99 1546 503165 128268 62856043
Ileal stenosis 111.02 11.99 99 504612 1614 62982697
Device malfunction 110.97 11.99 8 504703 17849 62966462
Bone marrow failure 110.67 11.99 47 504664 29243 62955068
Abnormal behaviour 109.68 11.99 19 504692 21407 62962904
Aphthous ulcer 109.65 11.99 300 504411 13638 62970673
Neutropenic sepsis 109.37 11.99 5 504706 16433 62967878
Right ventricular failure 108.85 11.99 7 504704 17181 62967130
Gastrointestinal disorder 108.34 11.99 1553 503158 129686 62854625
Sleep apnoea syndrome 108.09 11.99 48 504663 29085 62955226
Stevens-Johnson syndrome 107.99 11.99 32 504679 24918 62959393
Defaecation urgency 107.96 11.99 149 504562 4026 62980285
Urinary incontinence 107.84 11.99 60 504651 31954 62952357
Acute myocardial infarction 107.07 11.99 61 504650 32063 62952248
Lymph node tuberculosis 106.75 11.99 71 504640 728 62983583
Pneumonia 106.39 11.99 2791 501920 453976 62530335
Accidental overdose 106.32 11.99 27 504684 23282 62961029
Pouchitis 106.06 11.99 60 504651 447 62983864
Pneumonia legionella 105.63 11.99 95 504616 1567 62982744
Emotional distress 105.38 11.99 64 504647 32485 62951826
Leukopenia 105.30 11.99 292 504419 76998 62907313
Skin exfoliation 104.34 11.99 113 504598 42989 62941322
B-cell lymphoma 104.15 11.99 130 504581 3175 62981136
Confusional state 103.84 11.99 1291 503420 235089 62749222
Ankylosing spondylitis 103.79 11.99 246 504465 10228 62974083
Chronic kidney disease 103.42 11.99 125 504586 45273 62939038
Diabetic ketoacidosis 103.19 11.99 19 504692 20486 62963825
Psychotic disorder 102.49 11.99 38 504673 25674 62958637
Generalised tonic-clonic seizure 101.23 11.99 52 504659 28964 62955347
Thrombosis 101.18 11.99 228 504483 64527 62919784
Pleural effusion 100.79 11.99 390 504321 92820 62891491
Accidental exposure to product 100.35 11.99 46 504665 27359 62956952
Obstructive airways disorder 100.34 11.99 21 504690 20678 62963633
Contrast media allergy 100.01 11.99 109 504602 2292 62982019
Cytokine release syndrome 99.90 11.99 3 504708 14311 62970000
Bronchitis 98.71 11.99 585 504126 124350 62859961
Transient ischaemic attack 98.21 11.99 93 504618 37660 62946651
Ejection fraction decreased 97.84 11.99 28 504683 22304 62962007
Blood sodium decreased 96.41 11.99 36 504675 24216 62960095
Non-Hodgkin's lymphoma 96.30 11.99 84 504627 1328 62982983
Myalgia 95.79 11.99 726 503985 145803 62838508
Hepatocellular injury 95.63 11.99 49 504662 27332 62956979
Abdominal pain 95.59 11.99 3030 501681 290426 62693885
Human antichimeric antibody positive 95.43 11.99 91 504620 1623 62982688
Poisoning 95.15 11.99 3 504708 13697 62970614
Product administration error 94.64 11.99 30 504681 22367 62961944
Arrhythmia 94.56 11.99 98 504613 38042 62946269
Injection site mass 94.50 11.99 17 504694 18639 62965672
Status epilepticus 94.15 11.99 7 504704 15226 62969085
Skin necrosis 93.99 11.99 284 504427 13666 62970645
Femur fracture 92.98 11.99 117 504594 41639 62942672
Metastases to bone 92.74 11.99 26 504685 20993 62963318
Haemoptysis 92.28 11.99 57 504654 28669 62955642
Dry eye 92.04 11.99 113 504598 40648 62943663
Circulatory collapse 91.61 11.99 30 504681 21908 62962403
Ventricular tachycardia 91.40 11.99 23 504688 19956 62964355
No adverse event 91.18 11.99 117 504594 41288 62943023
Rash maculo-papular 90.95 11.99 72 504639 31824 62952487
COVID-19 90.81 11.99 1332 503379 111771 62872540
Antinuclear antibody positive 90.50 11.99 198 504513 7801 62976510
Large intestinal stenosis 90.41 11.99 94 504617 1869 62982442
Tuberculous pleurisy 90.37 11.99 51 504660 378 62983933
Hyperhidrosis 89.45 11.99 497 504214 107339 62876972
Injection site rash 89.31 11.99 20 504691 18789 62965522
Depressed mood 89.10 11.99 113 504598 40078 62944233
Dysuria 89.07 11.99 82 504629 33656 62950655
Sinus bradycardia 89.05 11.99 7 504704 14544 62969767
Speech disorder 88.24 11.99 116 504595 40513 62943798
Diarrhoea haemorrhagic 88.12 11.99 211 504500 8831 62975480
Renal disorder 87.22 11.99 80 504631 32894 62951417
Red blood cell sedimentation rate 86.88 11.99 146 504565 4708 62979603
Hepatic failure 86.84 11.99 93 504618 35563 62948748
Myoclonus 85.93 11.99 12 504699 15856 62968455
Restlessness 85.87 11.99 65 504646 29388 62954923
Respiratory depression 85.64 11.99 6 504705 13709 62970602
Muscle twitching 85.54 11.99 25 504686 19643 62964668
Sinus tachycardia 85.40 11.99 43 504668 24225 62960086
Haematemesis 85.03 11.99 70 504641 30342 62953969
Hallucination, auditory 85.00 11.99 4 504707 12820 62971491
Hyperlipidaemia 84.89 11.99 25 504686 19546 62964765
Body height below normal 83.87 11.99 95 504616 2088 62982223
Cervical dysplasia 83.55 11.99 115 504596 3099 62981212
Unevaluable event 83.52 11.99 177 504534 51209 62933102
Pain in extremity 83.42 11.99 2002 502709 329484 62654827
Disability 82.09 11.99 326 504385 18021 62966290
Physical disability 81.70 11.99 105 504606 2643 62981668
Throat tightness 81.61 11.99 403 504308 24484 62959827
Pollakiuria 81.01 11.99 62 504649 27875 62956436
Coronary artery disease 80.48 11.99 83 504628 32294 62952017
Anal stenosis 79.92 11.99 48 504663 405 62983906
Dry mouth 79.62 11.99 333 504378 77530 62906781
Extrapyramidal disorder 79.62 11.99 7 504704 13277 62971034
Electrolyte imbalance 79.47 11.99 30 504681 20046 62964265
Eosinophilia 79.06 11.99 41 504670 22715 62961596
Nightmare 78.84 11.99 27 504684 19167 62965144
Acute hepatic failure 78.42 11.99 24 504687 18303 62966008
Blood potassium increased 78.30 11.99 24 504687 18285 62966026
Intestinal operation 77.90 11.99 50 504661 480 62983831
Mammoplasty 77.74 11.99 51 504660 510 62983801
Squamous cell carcinoma 77.30 11.99 195 504516 8437 62975874
Subdural haematoma 77.20 11.99 11 504700 14317 62969994
Anuria 76.92 11.99 6 504705 12545 62971766
Chest discomfort 76.79 11.99 1265 503446 108704 62875607
Lymphoproliferative disorder 76.77 11.99 110 504601 3080 62981231
Myelosuppression 76.19 11.99 47 504664 23656 62960655
Delusion 75.79 11.99 5 504706 12012 62972299
Arthrodesis 75.51 11.99 102 504609 2699 62981612
Pancreatitis acute 75.37 11.99 63 504648 27103 62957208
Mydriasis 75.33 11.99 5 504706 11951 62972360
Antibody test positive 75.15 11.99 100 504611 2607 62981704
Jaundice 74.98 11.99 73 504638 29178 62955133
Haematuria 74.47 11.99 73 504638 29084 62955227
Sinus disorder 74.43 11.99 52 504659 24501 62959810
Coagulopathy 74.42 11.99 35 504676 20509 62963802
Hepatosplenic T-cell lymphoma 74.39 11.99 51 504660 552 62983759
Inappropriate antidiuretic hormone secretion 74.31 11.99 16 504695 15446 62968865
Deformity 74.19 11.99 233 504478 11451 62972860
Anhedonia 74.14 11.99 3 504708 10971 62973340
Abdominal pain upper 74.10 11.99 1174 503537 205270 62779041
Gamma-glutamyltransferase increased 74.07 11.99 97 504614 33934 62950377
Cardiogenic shock 74.05 11.99 25 504686 17907 62966404
Delirium 73.35 11.99 185 504526 50356 62933955
Sciatica 72.73 11.99 495 504216 33829 62950482
Listeriosis 72.15 11.99 74 504637 1447 62982864
Lower respiratory tract infection 72.08 11.99 1464 503247 130843 62853468
Premature labour 71.86 11.99 241 504470 12263 62972048
Type IV hypersensitivity reaction 71.32 11.99 101 504610 2797 62981514
DNA antibody positive 70.90 11.99 41 504670 320 62983991
Abortion spontaneous 70.23 11.99 627 504084 46568 62937743
Bronchitis chronic 70.15 11.99 125 504586 4228 62980083
Drug level abnormal 69.73 11.99 30 504681 111 62984200
Hemiparesis 69.66 11.99 50 504661 23232 62961079
General physical health deterioration 69.62 11.99 2095 502616 199307 62785004
Blood glucose decreased 69.52 11.99 40 504671 20912 62963399
Gastrointestinal inflammation 69.36 11.99 144 504567 5468 62978843
Dystonia 69.12 11.99 13 504698 13806 62970505
Thirst 68.57 11.99 14 504697 14027 62970284
Injection site warmth 68.54 11.99 18 504693 15177 62969134
Device difficult to use 68.53 11.99 10 504701 12786 62971525
Ulcer 68.08 11.99 397 504314 25710 62958601
Cerebral infarction 68.04 11.99 54 504657 23839 62960472
Blood pressure diastolic abnormal 67.97 11.99 16 504695 14526 62969785
Cervix carcinoma 67.69 11.99 101 504610 2936 62981375
Rectal abscess 67.45 11.99 66 504645 1217 62983094
Ileectomy 67.30 11.99 31 504680 140 62984171
Head injury 67.23 11.99 71 504640 27325 62956986
Vertigo 67.05 11.99 247 504464 59640 62924671
Surgical failure 66.95 11.99 58 504653 908 62983403
Ataxia 66.66 11.99 19 504692 15176 62969135
Needle issue 66.39 11.99 4 504707 10372 62973939
Schizophrenia 66.30 11.99 3 504708 9949 62974362
Infusion site reaction 65.68 11.99 109 504602 3478 62980833
Tinnitus 65.51 11.99 114 504597 35514 62948797
Urine output decreased 65.49 11.99 7 504704 11363 62972948
Grip strength decreased 65.49 11.99 350 504361 21937 62962374
Mania 65.47 11.99 10 504701 12357 62971954
Contraindication to vaccination 65.10 11.99 35 504676 233 62984078
Leukocytosis 65.01 11.99 66 504645 25869 62958442
Blood lactate dehydrogenase increased 64.88 11.99 53 504658 23063 62961248
Productive cough 64.83 11.99 270 504441 62938 62921373
Diabetes mellitus inadequate control 64.38 11.99 20 504691 15106 62969205
Coeliac disease 64.34 11.99 236 504475 12561 62971750
Wheelchair user 64.34 11.99 150 504561 6169 62978142
Device breakage 64.24 11.99 8 504703 11534 62972777
Ventricular fibrillation 64.20 11.99 9 504702 11858 62972453
Parkinsonism 63.95 11.99 5 504706 10434 62973877
Affect lability 63.88 11.99 7 504704 11144 62973167
Epilepsy 63.27 11.99 73 504638 26992 62957319
Adverse drug reaction 63.26 11.99 937 503774 78777 62905534
Transfusion 63.21 11.99 21 504690 15196 62969115
Colectomy total 62.88 11.99 30 504681 149 62984162
Tricuspid valve incompetence 62.83 11.99 19 504692 14602 62969709
Anal cancer 62.40 11.99 44 504667 500 62983811
Atypical mycobacterial infection 62.38 11.99 59 504652 1041 62983270
Cholangitis sclerosing 62.34 11.99 71 504640 1570 62982741
Therapy non-responder 62.13 11.99 897 503814 75004 62909307
Cholelithiasis 62.04 11.99 163 504548 43762 62940549
Dermatitis psoriasiform 62.02 11.99 83 504628 2176 62982135
Spinal column injury 61.97 11.99 79 504632 1972 62982339
Gastritis 61.88 11.99 127 504584 37176 62947135
Mesenteritis 61.52 11.99 36 504675 288 62984023
Ischaemic stroke 61.43 11.99 33 504678 17924 62966387
Onychomycosis 60.68 11.99 169 504542 7763 62976548
Akathisia 60.15 11.99 3 504708 9143 62975168
Cytopenia 60.01 11.99 10 504701 11591 62972720
Red cell distribution width decreased 59.98 11.99 78 504633 1987 62982324
Chromaturia 59.76 11.99 29 504682 16688 62967623
Acidosis 59.65 11.99 9 504702 11224 62973087
Injection site urticaria 59.20 11.99 19 504692 14054 62970257
Meningitis listeria 59.18 11.99 46 504665 613 62983698
Red blood cell count decreased 58.81 11.99 149 504562 40496 62943815
Haemorrhage intracranial 58.46 11.99 17 504694 13402 62970909
Complication associated with device 58.38 11.99 31 504680 16947 62967364
Brain oedema 58.25 11.99 20 504691 14175 62970136
Blood pressure systolic abnormal 58.24 11.99 17 504694 13369 62970942
Mental impairment 57.96 11.99 20 504691 14131 62970180
Hypocalcaemia 57.83 11.99 102 504609 31611 62952700
Respiratory tract infection 57.78 11.99 155 504556 41328 62942983
Hypothermia 57.73 11.99 18 504693 13563 62970748
Injection site induration 57.71 11.99 4 504707 9222 62975089
Intestinal obstruction 57.57 11.99 432 504279 30467 62953844
Neuralgia 57.35 11.99 73 504638 25853 62958458
Pneumonia viral 56.91 11.99 165 504546 7757 62976554
Oxygen saturation decreased 56.88 11.99 441 504270 88144 62896167
Abnormal dreams 56.83 11.99 8 504703 10508 62973803
Hypophosphataemia 56.62 11.99 11 504700 11415 62972896
Left ventricular dysfunction 56.41 11.99 13 504698 11975 62972336
Seasonal allergy 56.40 11.99 50 504661 20900 62963411
Hiatus hernia 56.39 11.99 53 504658 21541 62962770
Mycobacterium marinum infection 56.39 11.99 32 504679 240 62984071
Paraesthesia 56.18 11.99 893 503818 156073 62828238
Vaginal haemorrhage 56.16 11.99 82 504629 27405 62956906
Faecal calprotectin abnormal 56.10 11.99 23 504688 73 62984238
Headache 56.07 11.99 4305 500406 628936 62355375
Tumour lysis syndrome 55.94 11.99 4 504707 8986 62975325
Hyperbilirubinaemia 55.83 11.99 11 504700 11303 62973008
Cholecystitis chronic 55.72 11.99 8 504703 10353 62973958
Rales 55.47 11.99 16 504695 12681 62971630
Fibromyalgia 54.99 11.99 922 503789 79498 62904813
Vaginal fistula 54.92 11.99 38 504673 418 62983893
Hypoacusis 54.47 11.99 67 504644 24084 62960227
Pain in jaw 54.40 11.99 171 504540 43325 62940986
Paranoia 54.29 11.99 13 504698 11666 62972645
Tuberculin test positive 54.26 11.99 99 504612 3412 62980899
Pneumonitis 54.21 11.99 125 504586 35097 62949214
Hidradenitis 54.16 11.99 88 504623 2758 62981553
Nephrolithiasis 54.11 11.99 541 504170 41443 62942868
Dialysis 53.91 11.99 9 504702 10418 62973893
Fear 53.90 11.99 29 504682 15737 62968574
Treatment noncompliance 53.87 11.99 137 504574 37188 62947123
Subarachnoid haemorrhage 53.83 11.99 23 504688 14260 62970051
Liver disorder 53.70 11.99 658 504053 53029 62931282
Mood altered 53.58 11.99 25 504686 14718 62969593
Psychomotor hyperactivity 53.40 11.99 10 504701 10653 62973658
Glomerular filtration rate decreased 53.34 11.99 20 504691 13421 62970890
Haematocrit decreased 53.29 11.99 149 504562 39191 62945120
Thinking abnormal 53.26 11.99 10 504701 10633 62973678
Salmonellosis 52.89 11.99 56 504655 1138 62983173
Lymphopenia 52.72 11.99 41 504670 18286 62966025
Small intestinal resection 52.52 11.99 38 504673 451 62983860
Lymphoedema 52.45 11.99 14 504697 11678 62972633
Product substitution issue 52.42 11.99 31 504680 15965 62968346
Diplopia 52.29 11.99 67 504644 23661 62960650
Motor dysfunction 51.99 11.99 11 504700 10750 62973561
Dysphonia 51.60 11.99 199 504512 47415 62936896
Bone disorder 51.52 11.99 56 504655 21270 62963041
Laboratory test abnormal 51.43 11.99 84 504627 26828 62957483
Hypovolaemia 51.38 11.99 11 504700 10662 62973649
Burning sensation 51.20 11.99 240 504471 54167 62930144
Angioedema 51.00 11.99 202 504509 47763 62936548
Hip fracture 50.90 11.99 98 504613 29376 62954935
Lung neoplasm malignant 50.83 11.99 298 504413 19335 62964976
X-ray abnormal 50.83 11.99 161 504550 7949 62976362
Swelling face 50.76 11.99 296 504415 63179 62921132
Amyotrophic lateral sclerosis 50.55 11.99 54 504657 1109 62983202
Acute generalised exanthematous pustulosis 50.34 11.99 13 504698 11086 62973225
Proctectomy 50.26 11.99 23 504688 102 62984209
Nervousness 50.09 11.99 107 504604 30872 62953439
Prothrombin time prolonged 50.02 11.99 8 504703 9556 62974755
Cardiac failure acute 49.73 11.99 8 504703 9515 62974796
Hepatic encephalopathy 49.69 11.99 14 504697 11268 62973043
Dementia 49.23 11.99 46 504665 18748 62965563
Rhinitis allergic 49.03 11.99 16 504695 11711 62972600
Mean platelet volume decreased 48.73 11.99 81 504630 2588 62981723
Premature delivery 48.62 11.99 105 504606 30176 62954135
Sleep disorder due to a general medical condition 48.60 11.99 18 504693 12170 62972141
Product prescribing error 48.44 11.99 84 504627 26205 62958106
Osteonecrosis 48.35 11.99 75 504636 24455 62959856
Blood loss anaemia 48.29 11.99 7 504704 8994 62975317
Shock haemorrhagic 48.04 11.99 10 504701 9885 62974426
Metastases to central nervous system 47.97 11.99 22 504689 13083 62971228
Aplastic anaemia 47.86 11.99 9 504702 9560 62974751
Restless legs syndrome 47.78 11.99 46 504665 18485 62965826
Visual acuity reduced 47.72 11.99 62 504649 21764 62962547
Product complaint 47.68 11.99 21 504690 12788 62971523
Hysterectomy 47.61 11.99 175 504536 9324 62974987
Troponin increased 47.57 11.99 11 504700 10110 62974201
Haemodynamic instability 47.37 11.99 8 504703 9182 62975129
Ankle arthroplasty 47.32 11.99 65 504646 1748 62982563
Cardiomegaly 46.27 11.99 43 504668 17571 62966740
Stoma creation 46.25 11.99 16 504695 26 62984285
Incorrect drug administration rate 45.88 11.99 99 504612 3863 62980448
Joint arthroplasty 45.84 11.99 80 504631 2661 62981650
Infectious mononucleosis 45.41 11.99 66 504645 1873 62982438
Angina pectoris 45.29 11.99 108 504603 29970 62954341
Aspiration 45.03 11.99 15 504696 10836 62973475
Metastases to liver 44.97 11.99 74 504637 23565 62960746
Renal injury 44.89 11.99 10 504701 9429 62974882
Joint effusion 44.85 11.99 260 504451 16800 62967511
Antinuclear antibody increased 44.80 11.99 54 504657 1271 62983040
Device leakage 44.61 11.99 3 504708 7093 62977218
Proctocolectomy 44.51 11.99 17 504694 42 62984269
Rectal haemorrhage 44.41 11.99 590 504121 48440 62935871
Paradoxical psoriasis 44.23 11.99 26 504685 210 62984101
Device occlusion 43.98 11.99 4 504707 7383 62976928
Macular degeneration 43.91 11.99 79 504632 24297 62960014
Supraventricular tachycardia 43.55 11.99 30 504681 14241 62970070
Alanine aminotransferase increased 43.55 11.99 572 504139 103198 62881113
Loss of therapeutic response 43.55 11.99 38 504673 601 62983710
Wheezing 43.47 11.99 518 504193 95077 62889234
Aspartate aminotransferase increased 43.46 11.99 483 504228 89794 62894517
Atrial flutter 43.28 11.99 12 504699 9760 62974551
Double stranded DNA antibody 43.19 11.99 22 504689 129 62984182
Rectal stenosis 43.14 11.99 25 504686 196 62984115
Tonsillar ulcer 43.10 11.99 28 504683 275 62984036
Stress cardiomyopathy 42.99 11.99 11 504700 9439 62974872
Ankle operation 42.78 11.99 52 504659 1235 62983076
Intestinal fistula 42.75 11.99 44 504667 864 62983447
Mycobacterium avium complex infection 42.66 11.99 83 504628 3005 62981306
Retinitis 42.55 11.99 127 504584 6069 62978242
Sudden death 42.40 11.99 15 504696 10434 62973877
Injection site discolouration 42.34 11.99 6 504705 7842 62976469
Anticipatory anxiety 42.32 11.99 51 504660 1200 62983111
Peptic ulcer haemorrhage 41.92 11.99 47 504664 1021 62983290
Pseudopolyp 41.91 11.99 27 504684 261 62984050
Respiratory acidosis 41.75 11.99 3 504708 6712 62977599
Tonsillitis 41.73 11.99 120 504591 5615 62978696
Pruritus allergic 41.72 11.99 57 504654 1525 62982786
Drug exposure before pregnancy 41.72 11.99 44 504667 890 62983421
Anorectal disorder 41.64 11.99 60 504651 1689 62982622
Subcutaneous abscess 41.60 11.99 118 504593 5478 62978833
Obliterative bronchiolitis 41.54 11.99 66 504645 2029 62982282
Haemodialysis 41.51 11.99 10 504701 8937 62975374
Upper respiratory tract infection 41.49 11.99 434 504277 81613 62902698
Pyrexia 41.47 11.99 3199 501512 467279 62517032
Thrombotic microangiopathy 41.44 11.99 16 504695 10545 62973766
Fracture 41.42 11.99 57 504654 19527 62964784
Liver function test increased 41.41 11.99 421 504290 32390 62951921
Abdominal abscess 41.32 11.99 103 504608 4423 62979888
Anaphylactic reaction 41.29 11.99 747 503964 65353 62918958
Hospitalisation 41.03 11.99 455 504256 84626 62899685
Muscle rigidity 41.03 11.99 20 504691 11480 62972831
Vein rupture 40.95 11.99 50 504661 1193 62983118
Jaundice cholestatic 40.95 11.99 5 504706 7319 62976992
Listeria sepsis 40.88 11.99 39 504672 696 62983615
Toxic encephalopathy 40.73 11.99 3 504708 6576 62977735
Mental disorder 40.69 11.99 91 504620 25828 62958483
Eosinophil count increased 40.54 11.99 18 504693 10910 62973401
Osteopenia 40.44 11.99 59 504652 19726 62964585
Skin discolouration 40.41 11.99 159 504552 37669 62946642
Caesarean section 39.96 11.99 252 504459 16780 62967531
Skin burning sensation 39.89 11.99 26 504685 12708 62971603
Injection site haematoma 39.88 11.99 4 504707 6828 62977483
Nephropathy toxic 39.51 11.99 13 504698 9466 62974845
Coordination abnormal 39.38 11.99 31 504680 13742 62970569
Myelodysplastic syndrome 39.37 11.99 45 504666 16709 62967602
Oligohydramnios 39.13 11.99 3 504708 6363 62977948
Ageusia 39.12 11.99 31 504680 13697 62970614
Tubulointerstitial nephritis 39.09 11.99 61 504650 19842 62964469
Mean cell volume decreased 38.95 11.99 93 504618 3885 62980426
Salivary hypersecretion 38.80 11.99 7 504704 7659 62976652
Polyuria 38.75 11.99 10 504701 8532 62975779
Henoch-Schonlein purpura 38.67 11.99 47 504664 1116 62983195
Blood calcium increased 38.67 11.99 13 504698 9337 62974974
Lip ulceration 38.49 11.99 63 504648 1987 62982324
Product dose omission in error 38.42 11.99 7 504704 7605 62976706
Exposure via father 38.36 11.99 25 504686 247 62984064
Stoma obstruction 38.36 11.99 20 504691 124 62984187
Hypotonia 38.24 11.99 13 504698 9272 62975039
Malignant respiratory tract neoplasm 38.21 11.99 15 504696 41 62984270
Swollen tongue 37.99 11.99 145 504566 34655 62949656
Polyneuropathy 37.87 11.99 36 504675 14553 62969758
T-cell lymphoma 37.85 11.99 36 504675 640 62983671
Fistula discharge 37.70 11.99 45 504666 1048 62983263
Blood thyroid stimulating hormone increased 37.66 11.99 6 504705 7188 62977123
Petechiae 37.61 11.99 33 504678 13864 62970447
Cutaneous lupus erythematosus 37.60 11.99 73 504638 2639 62981672
Renal tubular necrosis 37.56 11.99 24 504687 11854 62972457
Rib fracture 37.42 11.99 77 504634 22520 62961791
Peripheral swelling 37.20 11.99 2522 502189 263420 62720891
Haemolytic anaemia 37.06 11.99 17 504694 10108 62974203
Cutaneous T-cell lymphoma 36.81 11.99 50 504661 1330 62982981
Immune thrombocytopenia 36.70 11.99 19 504692 10537 62973774
Neoplasm malignant 36.66 11.99 381 504330 29480 62954831
Intestinal anastomosis 36.63 11.99 30 504681 433 62983878
Blood pressure abnormal 36.61 11.99 40 504671 15158 62969153
Atelectasis 36.60 11.99 72 504639 21411 62962900
Shock 36.33 11.99 83 504628 23380 62960931
Gingival graft 36.21 11.99 13 504698 25 62984286
Posterior reversible encephalopathy syndrome 36.17 11.99 51 504660 17294 62967017
SAPHO syndrome 36.02 11.99 17 504694 82 62984229
Drug use disorder 35.99 11.99 104 504607 4880 62979431
Meningitis tuberculous 35.93 11.99 33 504678 560 62983751
Musculoskeletal disorder 35.88 11.99 284 504427 20360 62963951
Cytomegalovirus infection 35.74 11.99 287 504424 20665 62963646
Activated partial thromboplastin time prolonged 35.53 11.99 6 504705 6887 62977424
Hepatitis acute 35.48 11.99 14 504697 9106 62975205
Proteinuria 35.43 11.99 61 504650 19084 62965227
Cardiomyopathy 35.39 11.99 53 504658 17531 62966780
Peripheral sensory neuropathy 35.22 11.99 8 504703 7443 62976868
Wrist surgery 35.19 11.99 39 504672 836 62983475
Female genital tract fistula 35.18 11.99 136 504575 7423 62976888
Sensitivity to weather change 35.16 11.99 132 504579 7105 62977206
Chronic recurrent multifocal osteomyelitis 34.97 11.99 14 504697 41 62984270
Mitral valve incompetence 34.85 11.99 64 504647 19530 62964781
Metastases to lung 34.84 11.99 30 504681 12720 62971591
Urticaria 34.83 11.99 1632 503079 164170 62820141
Sneezing 34.68 11.99 57 504654 18161 62966150
Chest pain 34.68 11.99 1384 503327 214575 62769736
Prescribed underdose 34.67 11.99 375 504336 29314 62954997
Insurance issue 34.67 11.99 4 504707 6117 62978194
Suffocation feeling 34.64 11.99 48 504663 1302 62983009
Blood triglycerides increased 34.59 11.99 29 504682 12459 62971852
Small intestinal stenosis 34.56 11.99 32 504679 549 62983762
Bundle branch block left 34.55 11.99 7 504704 7052 62977259
Fistula repair 34.35 11.99 13 504698 31 62984280
Incorrect product administration duration 34.28 11.99 25 504686 11521 62972790
Amenorrhoea 34.24 11.99 18 504693 9896 62974415
Concomitant disease aggravated 33.82 11.99 15 504696 9097 62975214
Eye irritation 33.79 11.99 78 504633 21893 62962418
Coccidioidomycosis 33.76 11.99 40 504671 924 62983387
Pericardial effusion 33.62 11.99 124 504587 29934 62954377
Extrapulmonary tuberculosis 33.58 11.99 25 504686 311 62984000
Lip swelling 33.54 11.99 130 504581 30933 62953378
Hypertransaminasaemia 33.52 11.99 6 504705 6603 62977708
Dysstasia 33.48 11.99 74 504637 21092 62963219
Enterocutaneous fistula 33.37 11.99 48 504663 1349 62982962
Nasopharyngitis 33.26 11.99 2398 502313 251859 62732452
Hypoalbuminaemia 33.21 11.99 27 504684 11778 62972533
Anger 33.20 11.99 30 504681 12426 62971885
Hydronephrosis 33.09 11.99 22 504689 10640 62973671
Incorrect dosage administered 32.94 11.99 59 504652 2004 62982307
Enterostomy 32.89 11.99 20 504691 173 62984138
Taste disorder 32.86 11.99 36 504675 13626 62970685
Atrioventricular block 32.75 11.99 10 504701 7637 62976674
Visual impairment 32.74 11.99 473 504238 83973 62900338
Lipase increased 32.70 11.99 19 504692 9881 62974430
Lower gastrointestinal haemorrhage 32.58 11.99 11 504700 7879 62976432
Progressive multifocal leukoencephalopathy 32.52 11.99 33 504678 12938 62971373
Nocturia 32.50 11.99 12 504699 8129 62976182
Metabolic encephalopathy 32.40 11.99 4 504707 5805 62978506
Eye pruritus 32.31 11.99 62 504649 18609 62965702
Decubitus ulcer 32.26 11.99 22 504689 10498 62973813
Abscess intestinal 32.21 11.99 51 504660 1563 62982748
Oliguria 32.21 11.99 16 504695 9085 62975226
Bronchitis bacterial 32.18 11.99 37 504674 827 62983484
Cardiac murmur 32.16 11.99 41 504670 14511 62969800
Faecal volume decreased 31.86 11.99 19 504692 158 62984153
Pulmonary congestion 31.78 11.99 56 504655 17362 62966949
Glycosylated haemoglobin increased 31.71 11.99 31 504680 12367 62971944
Lung squamous cell carcinoma recurrent 31.57 11.99 10 504701 10 62984301
Atrioventricular block complete 31.55 11.99 13 504698 8238 62976073
Serum ferritin decreased 31.52 11.99 58 504653 2012 62982299
Pharyngeal paraesthesia 31.49 11.99 57 504654 1952 62982359
Feeling jittery 31.49 11.99 36 504675 13367 62970944
Emotional disorder 31.36 11.99 36 504675 13343 62970968
Temperature intolerance 31.36 11.99 16 504695 8948 62975363
Ventricular extrasystoles 31.33 11.99 28 504683 11659 62972652
Onychomadesis 31.32 11.99 110 504601 5730 62978581
Body temperature decreased 31.29 11.99 272 504439 20047 62964264
Tuberculosis gastrointestinal 31.26 11.99 25 504686 348 62983963
Pneumonia cryptococcal 31.16 11.99 35 504676 762 62983549
Dental caries 31.15 11.99 24 504687 10755 62973556
Septic shock 31.07 11.99 359 504352 66270 62918041
Torus fracture 30.87 11.99 18 504693 143 62984168
Vitamin D deficiency 30.85 11.99 39 504672 13853 62970458
Nystagmus 30.79 11.99 6 504705 6214 62978097
Middle insomnia 30.76 11.99 33 504678 12610 62971701
Genital haemorrhage 30.66 11.99 10 504701 7322 62976989
Hemiplegia 30.64 11.99 18 504693 9305 62975006
Febrile bone marrow aplasia 30.62 11.99 10 504701 7315 62976996
Adjustment disorder with depressed mood 30.49 11.99 161 504550 10043 62974268
Poor quality sleep 30.48 11.99 71 504640 19864 62964447
Spinal fracture 30.47 11.99 62 504649 18209 62966102
Blood magnesium decreased 30.42 11.99 36 504675 13162 62971149
Urine abnormality 30.38 11.99 9 504702 7010 62977301
Apathy 30.32 11.99 16 504695 8778 62975533
Internal haemorrhage 30.21 11.99 3 504708 5162 62979149
Hair follicle tumour benign 30.12 11.99 26 504685 405 62983906
Protein urine present 30.10 11.99 6 504705 6114 62978197
Haemorrhage 29.95 11.99 325 504386 60697 62923614
Myopathy 29.77 11.99 27 504684 11164 62973147
Hypercapnia 29.66 11.99 4 504707 5427 62978884
Multiple sclerosis 29.65 11.99 97 504614 24275 62960036
Disseminated coccidioidomycosis 29.64 11.99 13 504698 51 62984260
Nasal polyps 29.53 11.99 6 504705 6033 62978278
Fine motor skill dysfunction 29.52 11.99 95 504616 4730 62979581
Infusion site extravasation 29.46 11.99 162 504549 10264 62974047
Prescribed overdose 29.29 11.99 407 504304 33746 62950565
Product storage error 29.22 11.99 46 504665 14910 62969401
Blood uric acid increased 29.20 11.99 4 504707 5363 62978948
Pathological fracture 29.12 11.99 17 504694 8817 62975494
Heavy menstrual bleeding 29.06 11.99 61 504650 17712 62966599
Smear cervix abnormal 28.98 11.99 69 504642 2877 62981434
Large intestinal ulcer 28.98 11.99 76 504635 3368 62980943
Infusion site erythema 28.96 11.99 30 504681 11649 62972662
Product physical issue 28.85 11.99 3 504708 4977 62979334
Flatulence 28.72 11.99 160 504551 34542 62949769
Blood creatine increased 28.59 11.99 5 504706 5596 62978715
Ear pain 28.57 11.99 169 504542 35949 62948362
Skin ulcer 28.50 11.99 491 504220 42554 62941757
Neutrophil count increased 28.50 11.99 55 504656 16472 62967839
Unintended pregnancy 28.48 11.99 7 504704 6172 62978139
COVID-19 pneumonia 28.43 11.99 43 504668 14166 62970145
Duodenal ulcer 28.42 11.99 13 504698 7743 62976568
Post-traumatic stress disorder 28.36 11.99 4 504707 5247 62979064
Eye movement disorder 28.20 11.99 4 504707 5224 62979087
Mycobacterium chelonae infection 28.16 11.99 27 504684 485 62983826
Proctitis 27.91 11.99 101 504610 5340 62978971
Medication error 27.90 11.99 273 504438 52011 62932300
Exercise tolerance decreased 27.86 11.99 5 504706 5492 62978819
Tooth disorder 27.81 11.99 122 504589 28035 62956276
Spinal osteoarthritis 27.79 11.99 54 504657 16132 62968179
Application site erythema 27.79 11.99 3 504708 4832 62979479
Hepatic cytolysis 27.69 11.99 50 504661 15357 62968954
Infected fistula 27.69 11.99 19 504692 206 62984105
Nephropathy 27.68 11.99 8 504703 6333 62977978
Gastric ulcer 27.65 11.99 98 504613 23939 62960372
Dermatitis contact 27.61 11.99 28 504683 10980 62973331
Rheumatoid lung 27.50 11.99 80 504631 3768 62980543
Intervertebral disc degeneration 27.43 11.99 52 504659 15680 62968631
Suspected COVID-19 27.39 11.99 62 504649 2500 62981811
Device failure 27.34 11.99 7 504704 6004 62978307
Bowel movement irregularity 27.24 11.99 98 504613 5166 62979145
Hereditary angioedema 27.21 11.99 13 504698 7549 62976762
Sleep disorder 27.20 11.99 470 504241 81096 62903215
Colitis ischaemic 27.12 11.99 27 504684 10681 62973630
Cholecystitis acute 27.08 11.99 16 504695 8244 62976067
White blood cell count abnormal 27.02 11.99 8 504703 6234 62978077
Hyperuricaemia 26.97 11.99 5 504706 5365 62978946
Rectal tenesmus 26.94 11.99 34 504677 840 62983471
Guttate psoriasis 26.76 11.99 25 504686 434 62983877
Toxic skin eruption 26.75 11.99 38 504673 12847 62971464
Diastolic dysfunction 26.75 11.99 9 504702 6462 62977849
Bradyphrenia 26.69 11.99 11 504700 6969 62977342
Systemic infection 26.51 11.99 3 504708 4657 62979654
Ammonia increased 26.48 11.99 3 504708 4653 62979658
Initial insomnia 26.46 11.99 8 504703 6149 62978162
Mean cell haemoglobin decreased 26.45 11.99 96 504615 5083 62979228
Sports injury 26.38 11.99 10 504701 24 62984287
Pulmonary haemorrhage 26.37 11.99 12 504699 7169 62977142
Hypertonia 26.34 11.99 3 504708 4634 62979677
Clonus 26.33 11.99 3 504708 4633 62979678
Dyspepsia 26.24 11.99 615 504096 101581 62882730
IgA nephropathy 26.14 11.99 28 504683 577 62983734
Gastrointestinal scarring 26.06 11.99 22 504689 332 62983979
Intentional dose omission 25.97 11.99 16 504695 8059 62976252
Skin laceration 25.85 11.99 93 504618 22615 62961696
Varicella 25.77 11.99 51 504660 1870 62982441
Lupus vasculitis 25.76 11.99 27 504684 542 62983769
Gout 25.75 11.99 41 504670 13230 62971081
Peritonitis bacterial 25.70 11.99 4 504707 4875 62979436
Bradykinesia 25.69 11.99 5 504706 5183 62979128
Fear of injection 25.65 11.99 119 504592 7045 62977266
Impaired gastric emptying 25.58 11.99 155 504556 10177 62974134
Foetal exposure during pregnancy 25.57 11.99 149 504562 31813 62952498
Intestinal tuberculosis 25.55 11.99 13 504698 76 62984235
Influenza 25.55 11.99 663 504048 108059 62876252
Lower respiratory tract infection viral 25.53 11.99 34 504677 887 62983424
Wisdom teeth removal 25.53 11.99 27 504684 548 62983763
Anastomotic stenosis 25.52 11.99 20 504691 270 62984041
Coma scale abnormal 25.45 11.99 5 504706 5148 62979163
Eye pain 25.42 11.99 161 504550 33693 62950618
Hypertensive crisis 25.38 11.99 52 504659 15234 62969077
Orthopnoea 25.38 11.99 9 504702 6252 62978059
Tachypnoea 25.36 11.99 63 504648 17239 62967072
Metabolic disorder 25.27 11.99 10 504701 6493 62977818
Aplasia pure red cell 25.24 11.99 3 504708 4484 62979827
Dermatitis atopic 25.23 11.99 24 504687 9700 62974611
Product label confusion 25.21 11.99 49 504662 1773 62982538
Substance abuse 25.19 11.99 4 504707 4803 62979508
Catatonia 25.17 11.99 3 504708 4474 62979837
Ear infection bacterial 25.16 11.99 16 504695 151 62984160
Azotaemia 25.13 11.99 3 504708 4468 62979843
Arthritis enteropathic 24.98 11.99 20 504691 279 62984032
Colostomy 24.96 11.99 34 504677 907 62983404
Body height decreased 24.86 11.99 26 504685 10052 62974259
Nail disorder 24.83 11.99 183 504528 12832 62971479
Erythema 24.78 11.99 1668 503043 174083 62810228
Mouth ulceration 24.72 11.99 384 504327 32600 62951711
Hypercholesterolaemia 24.69 11.99 269 504442 21065 62963246
Enterocolitis 24.68 11.99 16 504695 7842 62976469
Drug eruption 24.63 11.99 342 504369 28352 62955959
Amnesia 24.58 11.99 303 504408 55282 62929029
Device related infection 24.56 11.99 99 504612 23293 62961018
Central nervous system lesion 24.52 11.99 29 504682 10606 62973705
Ileostomy closure 24.51 11.99 18 504693 219 62984092
Hepatitis cholestatic 24.48 11.99 12 504699 6866 62977445
Paternal exposure during pregnancy 24.45 11.99 14 504697 107 62984204
Bartholin's cyst 24.43 11.99 7 504704 3 62984308
Diffuse large B-cell lymphoma 24.41 11.99 112 504599 6600 62977711
Faeces discoloured 24.41 11.99 71 504640 18438 62965873
Partial seizures 24.37 11.99 8 504703 5834 62978477
Soft tissue disorder 24.33 11.99 84 504627 4338 62979973
Tachycardia 24.32 11.99 734 503977 117422 62866889
Apnoea 24.30 11.99 17 504694 8005 62976306
Hyperthyroidism 24.29 11.99 50 504661 14623 62969688
Dislocation of vertebra 24.28 11.99 134 504577 8501 62975810
Disease susceptibility 24.27 11.99 17 504694 191 62984120
Transaminases increased 24.16 11.99 148 504563 31219 62953092
Weight fluctuation 24.11 11.99 147 504564 9672 62974639
Joint range of motion decreased 24.10 11.99 377 504334 32051 62952260
Small intestine carcinoma 24.08 11.99 24 504687 453 62983858
Abdominal distension 24.01 11.99 515 504196 86100 62898211
Eyelid ptosis 23.93 11.99 14 504697 7253 62977058
Granuloma 23.89 11.99 100 504611 5661 62978650
Respiratory syncytial virus infection 23.86 11.99 13 504698 7005 62977306
Lung cancer metastatic 23.85 11.99 59 504652 2521 62981790
Brain natriuretic peptide increased 23.85 11.99 6 504705 5207 62979104
Diabetic eye disease 23.81 11.99 15 504696 139 62984172
Non-cardiac chest pain 23.80 11.99 10 504701 6262 62978049
Acute pulmonary oedema 23.78 11.99 18 504693 8140 62976171
Hypermobility syndrome 23.77 11.99 31 504680 792 62983519
Catheter site erythema 23.71 11.99 3 504708 4273 62980038
Stupor 23.70 11.99 3 504708 4272 62980039
Oral mucosal blistering 23.66 11.99 8 504703 5725 62978586
Presyncope 23.60 11.99 127 504584 27658 62956653
Hypovolaemic shock 23.60 11.99 10 504701 6231 62978080
Patent ductus arteriosus 23.52 11.99 3 504708 4247 62980064
Tuberculosis liver 23.51 11.99 8 504703 12 62984299
Anal fistula infection 23.45 11.99 10 504701 36 62984275
Electrocardiogram abnormal 23.42 11.99 23 504688 9156 62975155
Aortic arteriosclerosis 23.40 11.99 10 504701 6199 62978112
Drug level increased 23.38 11.99 97 504614 22639 62961672
Proctitis ulcerative 23.38 11.99 19 504692 271 62984040
Hot flush 23.33 11.99 277 504434 50882 62933429
Injection site reaction 23.32 11.99 326 504385 58198 62926113
Oesophagitis 23.31 11.99 53 504658 14955 62969356
Dyslipidaemia 23.29 11.99 15 504696 7378 62976933
Opportunistic infection 23.26 11.99 49 504662 1880 62982431
Purpura 23.22 11.99 34 504677 11351 62972960
Snoring 23.18 11.99 3 504708 4199 62980112
Lacrimation increased 23.15 11.99 85 504626 20546 62963765
Clear cell renal cell carcinoma 23.11 11.99 42 504669 1443 62982868
Breast cancer stage I 23.07 11.99 13 504698 6876 62977435
Bone tuberculosis 23.07 11.99 17 504694 208 62984103
Nerve injury 23.06 11.99 27 504684 9919 62974392
International normalised ratio decreased 23.02 11.99 4 504707 4497 62979814
Hepatomegaly 22.82 11.99 37 504674 11852 62972459
Left ventricular hypertrophy 22.67 11.99 7 504704 5308 62979003
Vitamin B12 deficiency 22.59 11.99 7 504704 5296 62979015
Therapy change 22.59 11.99 10 504701 6071 62978240
Catheter site pain 22.55 11.99 5 504706 4730 62979581
Urine analysis abnormal 22.51 11.99 6 504705 5010 62979301
Depressive symptom 22.45 11.99 3 504708 4099 62980212
Blood chloride decreased 22.41 11.99 8 504703 5534 62978777
Cystitis 22.38 11.99 305 504406 54686 62929625
Rash papular 22.37 11.99 58 504653 15644 62968667
Haemolysis 22.34 11.99 13 504698 6755 62977556
Brachiocephalic artery stenosis 22.32 11.99 9 504702 27 62984284
Graft versus host disease 22.31 11.99 13 504698 6750 62977561
Blood glucose abnormal 22.27 11.99 18 504693 7874 62976437
Growth retardation 22.25 11.99 39 504672 1302 62983009
Intestinal sepsis 22.17 11.99 19 504692 293 62984018
Hypertriglyceridaemia 22.16 11.99 11 504700 6248 62978063
Bowen's disease 22.15 11.99 17 504694 222 62984089
Failure to thrive 22.14 11.99 15 504696 7183 62977128
Erythema multiforme 22.11 11.99 29 504682 10140 62974171
Eczema infected 22.09 11.99 10 504701 43 62984268
Sexual dysfunction 22.02 11.99 4 504707 4355 62979956
Myocardial ischaemia 21.99 11.99 43 504668 12816 62971495
Muscle tightness 21.94 11.99 38 504673 11862 62972449
Tension headache 21.82 11.99 7 504704 5179 62979132
Cholecystitis 21.76 11.99 57 504654 15320 62968991
Acute myeloid leukaemia 21.73 11.99 67 504644 17080 62967231
Drug tolerance 21.70 11.99 111 504600 6838 62977473
Respiratory tract congestion 21.67 11.99 71 504640 17761 62966550
Tonsillitis streptococcal 21.66 11.99 11 504700 64 62984247
Facet joint syndrome 21.65 11.99 168 504543 11970 62972341
Euphoric mood 21.64 11.99 6 504705 4881 62979430
Arteriosclerosis 21.59 11.99 29 504682 10037 62974274
Epstein-Barr virus associated lymphoproliferative disorder 21.56 11.99 47 504664 1847 62982464
Blood thyroid stimulating hormone decreased 21.55 11.99 5 504706 4585 62979726
Hypoxic-ischaemic encephalopathy 21.51 11.99 4 504707 4283 62980028
Vaginal abscess 21.34 11.99 22 504689 433 62983878
Oral discomfort 21.31 11.99 25 504686 9176 62975135
Panic attack 21.30 11.99 98 504613 22233 62962078
Salpingectomy 21.24 11.99 17 504694 237 62984074
Brain injury 21.23 11.99 15 504696 7028 62977283
Neuroendocrine carcinoma of the skin 21.19 11.99 25 504686 575 62983736
Atrioventricular block second degree 21.10 11.99 3 504708 3911 62980400
Crohn's disease 20.94 11.99 86 504625 4827 62979484
Skin abrasion 20.91 11.99 26 504685 9303 62975008
Peripheral arterial occlusive disease 20.91 11.99 4 504707 4197 62980114
Adhesiolysis 20.88 11.99 8 504703 20 62984291
Post transplant lymphoproliferative disorder 20.80 11.99 7 504704 5024 62979287
Haemorrhagic stroke 20.78 11.99 10 504701 5782 62978529
Product substitution 20.77 11.99 7 504704 10 62984301
Legionella infection 20.74 11.99 22 504689 448 62983863
Vulval abscess 20.70 11.99 30 504681 849 62983462
Obesity 20.68 11.99 344 504367 29608 62954703
Colon cancer 20.65 11.99 142 504569 9736 62974575
Rectal cancer 20.64 11.99 50 504661 2108 62982203
Pneumocystis jirovecii infection 20.64 11.99 40 504671 1444 62982867
Bundle branch block right 20.58 11.99 7 504704 4991 62979320
End stage renal disease 20.52 11.99 14 504697 6679 62977632
Anaplastic large-cell lymphoma 20.51 11.99 12 504699 96 62984215
Investigation abnormal 20.51 11.99 47 504664 1911 62982400
Hepatic steatosis 20.50 11.99 139 504572 28630 62955681
Low birth weight baby 20.44 11.99 16 504695 7113 62977198
Musculoskeletal chest pain 20.43 11.99 92 504619 20991 62963320
Wound infection 20.37 11.99 260 504451 21150 62963161
Haemorrhagic diathesis 20.36 11.99 5 504706 4410 62979901
Neck mass 20.31 11.99 69 504642 3534 62980777
Neutrophilia 20.29 11.99 5 504706 4401 62979910
Scleroderma 20.26 11.99 9 504702 5453 62978858
Papilloma viral infection 20.25 11.99 41 504670 1529 62982782
Blindness 20.24 11.99 96 504615 21603 62962708
Retching 20.18 11.99 55 504656 14590 62969721
Facial pain 20.14 11.99 33 504678 10528 62973783
Neck deformity 20.14 11.99 49 504662 2072 62982239
Deep vein thrombosis postoperative 20.08 11.99 157 504554 11212 62973099
Skin hyperpigmentation 20.08 11.99 11 504700 5910 62978401
Intermenstrual bleeding 20.06 11.99 20 504691 7906 62976405
Multiple-drug resistance 20.01 11.99 8 504703 5162 62979149
Acute pulmonary histoplasmosis 19.98 11.99 13 504698 128 62984183
Product use in unapproved indication 19.93 11.99 1668 503043 177412 62806899
Colostomy closure 19.90 11.99 13 504698 129 62984182
Streptococcal infection 19.90 11.99 95 504616 5692 62978619
Intestinal ischaemia 19.89 11.99 18 504693 7450 62976861
Low density lipoprotein increased 19.89 11.99 13 504698 6344 62977967
Gangrene 19.87 11.99 12 504699 6111 62978200
Dermatitis bullous 19.83 11.99 23 504688 8485 62975826
Blood pressure diastolic increased 19.82 11.99 142 504569 9868 62974443
Anti-cyclic citrullinated peptide antibody 19.76 11.99 106 504605 6652 62977659
Inflammatory bowel disease 19.75 11.99 73 504638 3900 62980411
Pyoderma 19.70 11.99 19 504692 344 62983967
Upper-airway cough syndrome 19.68 11.99 38 504673 11380 62972931
Perineal abscess 19.67 11.99 18 504693 304 62984007
Crying 19.66 11.99 107 504604 23236 62961075
Intercepted product prescribing error 19.60 11.99 15 504696 195 62984116
Back disorder 19.58 11.99 36 504675 10981 62973330
White blood cell count increased 19.52 11.99 270 504441 48291 62936020
Joint injury 19.46 11.99 337 504374 29235 62955076
Major depression 19.43 11.99 21 504690 7997 62976314
Cerebral ischaemia 19.42 11.99 15 504696 6713 62977598
Spinal compression fracture 19.41 11.99 54 504657 14229 62970082
Foot fracture 19.39 11.99 111 504600 23803 62960508
Lupus hepatitis 19.37 11.99 8 504703 26 62984285
Hypogammaglobulinaemia 19.35 11.99 17 504694 7138 62977173
Pus in stool 19.31 11.99 9 504702 42 62984269
Renal function test abnormal 19.23 11.99 3 504708 3650 62980661
Anal dilatation 19.21 11.99 5 504706 0 62984311
Takayasu's arteritis 19.21 11.99 5 504706 0 62984311
Steroid dependence 19.21 11.99 43 504668 1721 62982590
Clostridium difficile colitis 19.19 11.99 91 504620 20478 62963833
Blood test abnormal 19.15 11.99 62 504649 15567 62968744
Pulmonary function test decreased 19.14 11.99 4 504707 3943 62980368
Gastrointestinal toxicity 19.06 11.99 20 504691 7721 62976590
Drug screen positive 19.06 11.99 3 504708 3626 62980685
Normal newborn 18.96 11.99 23 504688 8318 62975993
Tooth loss 18.89 11.99 16 504695 6840 62977471
Sinus congestion 18.84 11.99 77 504634 18046 62966265
Joint tuberculosis 18.80 11.99 12 504699 114 62984197
Injection site irritation 18.78 11.99 8 504703 4970 62979341
Blood phosphorus decreased 18.75 11.99 6 504705 4447 62979864
Oedema 18.74 11.99 612 504099 97010 62887301
Enteropathic spondylitis 18.72 11.99 8 504703 29 62984282
Dysphoria 18.71 11.99 8 504703 4958 62979353
Pericarditis tuberculous 18.70 11.99 7 504704 16 62984295
Pharyngitis streptococcal 18.65 11.99 147 504564 10525 62973786
Cutaneous tuberculosis 18.64 11.99 13 504698 145 62984166
Tongue disorder 18.63 11.99 146 504565 10434 62973877
Influenza like illness 18.62 11.99 397 504314 66427 62917884
Spinal operation 18.59 11.99 23 504688 8248 62976063
Acute graft versus host disease 18.59 11.99 6 504705 4422 62979889
C-reactive protein decreased 18.54 11.99 30 504681 937 62983374
Extra dose administered 18.53 11.99 14 504697 6336 62977975
Oxygen saturation abnormal 18.52 11.99 66 504645 3463 62980848
Fistula inflammation 18.47 11.99 6 504705 7 62984304
Blood immunoglobulin E increased 18.46 11.99 4 504707 3845 62980466
Palpitations 18.45 11.99 721 503990 112049 62872262
Cerebellar syndrome 18.42 11.99 3 504708 3536 62980775
Carcinoma in situ of skin 18.40 11.99 15 504696 215 62984096
Hypercalcaemia 18.37 11.99 322 504389 28000 62956311
Product availability issue 18.36 11.99 5 504706 4116 62980195
Gastrointestinal stenosis 18.36 11.99 14 504697 181 62984130
Skin atrophy 18.33 11.99 8 504703 4898 62979413
Ventricular arrhythmia 18.32 11.99 4 504707 3824 62980487
Live birth 18.31 11.99 296 504415 25334 62958977
Ventricular hypokinesia 18.28 11.99 7 504704 4637 62979674
Ventricular septal defect 18.26 11.99 6 504705 4372 62979939
Perirectal abscess 18.19 11.99 29 504682 894 62983417
Coronary artery occlusion 18.18 11.99 23 504688 8168 62976143
Atrial septal defect 18.15 11.99 17 504694 6921 62977390
Anorectal ulcer 18.06 11.99 9 504702 50 62984261
Catheterisation cardiac 18.02 11.99 7 504704 4596 62979715
Proctalgia 17.98 11.99 96 504615 6014 62978297
Obsessive-compulsive disorder 17.95 11.99 5 504706 4055 62980256
Thoracic vertebral fracture 17.95 11.99 7 504704 4585 62979726
Supraventricular extrasystoles 17.93 11.99 7 504704 4582 62979729
Infusion site haemorrhage 17.91 11.99 9 504702 5077 62979234
Vascular device infection 17.88 11.99 19 504692 7293 62977018
Bacteraemia 17.85 11.99 74 504637 17274 62967037
Blood glucose fluctuation 17.84 11.99 7 504704 4569 62979742
Cervix carcinoma stage 0 17.84 11.99 18 504693 345 62983966
Eating disorder 17.82 11.99 84 504627 18932 62965379
Respiratory distress 17.81 11.99 178 504533 33773 62950538
Joint dislocation 17.76 11.99 228 504483 18572 62965739
Lung neoplasm 17.74 11.99 94 504617 5872 62978439
Obstruction 17.73 11.99 60 504651 3067 62981244
Non-consummation 17.64 11.99 9 504702 53 62984258
Vitreous floaters 17.60 11.99 13 504698 5953 62978358
Muscle strain 17.58 11.99 24 504687 8250 62976061
Lupus vulgaris 17.52 11.99 94 504617 5900 62978411
Brain death 17.51 11.99 3 504708 3407 62980904
Nasal discomfort 17.41 11.99 8 504703 4752 62979559
Loose tooth 17.39 11.99 3 504708 3391 62980920
Hypoventilation 17.37 11.99 8 504703 4746 62979565
Hair texture abnormal 17.37 11.99 6 504705 4237 62980074
Left ventricular failure 17.29 11.99 12 504699 5675 62978636
Complications of bone marrow transplant 17.26 11.99 20 504691 451 62983860
Hodgkin's disease stage II 17.25 11.99 6 504705 10 62984301
Occult blood positive 17.23 11.99 4 504707 3666 62980645
Accident 17.23 11.99 94 504617 5938 62978373
Limb injury 17.22 11.99 125 504586 25352 62958959
Iritis 17.20 11.99 60 504651 3115 62981196
Dizziness postural 17.13 11.99 20 504691 7356 62976955
Anorectal discomfort 17.10 11.99 53 504658 2586 62981725
Electrocardiogram ST segment elevation 17.06 11.99 5 504706 3922 62980389
Therapeutic product effect variable 17.05 11.99 33 504678 1190 62983121
Pelvic pain 17.01 11.99 53 504658 13466 62970845
Pelvic abscess 16.95 11.99 40 504671 1658 62982653
Neoplasm skin 16.94 11.99 38 504673 1523 62982788
Lip neoplasm malignant stage unspecified 16.89 11.99 7 504704 23 62984288
Laryngeal disorder 16.89 11.99 30 504681 1012 62983299
Eructation 16.88 11.99 25 504686 8308 62976003
Candida infection 16.88 11.99 144 504567 28207 62956104
Sensory loss 16.85 11.99 35 504676 10203 62974108
Splenomegaly 16.84 11.99 40 504671 11117 62973194
Ankle deformity 16.81 11.99 20 504691 464 62983847
Plasmablastic lymphoma 16.81 11.99 14 504697 207 62984104
Galactorrhoea 16.80 11.99 6 504705 4149 62980162
Infrequent bowel movements 16.79 11.99 34 504677 1268 62983043
International normalised ratio abnormal 16.76 11.99 3 504708 3301 62981010
Lung consolidation 16.75 11.99 6 504705 4142 62980169
Gastrointestinal carcinoma 16.73 11.99 46 504665 2097 62982214
Mycobacterial infection 16.72 11.99 41 504670 1742 62982569
Ophthalmic herpes zoster 16.69 11.99 45 504666 2028 62982283
Conjunctival haemorrhage 16.66 11.99 4 504707 3583 62980728
Enzyme level increased 16.63 11.99 17 504694 331 62983980
Cardiac pacemaker insertion 16.61 11.99 6 504705 4120 62980191
White coat hypertension 16.59 11.99 24 504687 678 62983633
Onychoclasis 16.57 11.99 15 504696 6207 62978104
Pain of skin 16.56 11.99 43 504668 11591 62972720
Micturition urgency 16.56 11.99 32 504679 9579 62974732
Rash erythematous 16.51 11.99 238 504473 42272 62942039
Autoimmune haemolytic anaemia 16.42 11.99 8 504703 4593 62979718
Hypoaesthesia 16.38 11.99 1135 503576 167258 62817053
SARS-CoV-2 test positive 16.37 11.99 115 504596 7941 62976370
Pathogen resistance 16.36 11.99 16 504695 6382 62977929
Portal hypertension 16.34 11.99 5 504706 3814 62980497
Hodgkin's disease mixed cellularity stage unspecified 16.31 11.99 5 504706 4 62984307
Arterial occlusive disease 16.30 11.99 14 504697 5944 62978367
Rotator cuff syndrome 16.24 11.99 54 504657 13448 62970863
Shoulder arthroplasty 16.24 11.99 69 504642 3933 62980378
Hypersomnia 16.19 11.99 81 504630 17974 62966337
Sluggishness 16.18 11.99 11 504700 5258 62979053
Antibody test abnormal 16.15 11.99 21 504690 535 62983776
Ectopic pregnancy 16.12 11.99 51 504660 2516 62981795
Ileus paralytic 16.11 11.99 8 504703 4543 62979768
Maternal exposure timing unspecified 16.09 11.99 104 504607 6983 62977328
Amylase increased 16.07 11.99 16 504695 6329 62977982
Epicondylitis 15.98 11.99 46 504665 2154 62982157
Limb operation 15.97 11.99 69 504642 3962 62980349
Hepatotoxicity 15.97 11.99 203 504508 36838 62947473
Chronic disease 15.94 11.99 12 504699 152 62984159
Endometriosis 15.94 11.99 84 504627 5236 62979075
Viral infection 15.92 11.99 194 504517 35469 62948842
Nerve compression 15.88 11.99 30 504681 9057 62975254
Tooth fracture 15.86 11.99 41 504670 11069 62973242
Photopsia 15.85 11.99 8 504703 4501 62979810
Increased tendency to bruise 15.80 11.99 38 504673 10514 62973797
Appetite disorder 15.79 11.99 21 504690 7300 62977011
Spleen tuberculosis 15.79 11.99 5 504706 5 62984306
Escherichia urinary tract infection 15.69 11.99 46 504665 11916 62972395
Large intestine anastomosis 15.67 11.99 7 504704 29 62984282
Viral pericarditis 15.67 11.99 7 504704 29 62984282
Varices oesophageal 15.66 11.99 3 504708 3145 62981166
Joint stiffness 15.66 11.99 440 504271 41429 62942882
Loss of consciousness 15.65 11.99 773 503938 117348 62866963
Blood phosphorus increased 15.64 11.99 3 504708 3142 62981169
Lip dry 15.64 11.99 190 504521 15280 62969031
Myocarditis 15.60 11.99 37 504674 10288 62974023
Stomatitis 15.57 11.99 1293 503418 137432 62846879
Genital cyst 15.56 11.99 8 504703 48 62984263
Extrasystoles 15.54 11.99 11 504700 5149 62979162
Product dispensing error 15.51 11.99 37 504674 10268 62974043
Herpes ophthalmic 15.49 11.99 33 504678 1276 62983035
Tachyarrhythmia 15.48 11.99 8 504703 4442 62979869
Lumbar vertebral fracture 15.48 11.99 14 504697 5796 62978515
Sinus node dysfunction 15.46 11.99 9 504702 4676 62979635
Short stature 15.46 11.99 23 504688 667 62983644
Areflexia 15.45 11.99 3 504708 3115 62981196
Scleritis 15.45 11.99 73 504638 4355 62979956
Squamous cell carcinoma of lung 15.41 11.99 27 504684 901 62983410
Performance status decreased 15.41 11.99 5 504706 3673 62980638
Sydenham's chorea 15.37 11.99 4 504707 0 62984311
Malignant melanoma of sites other than skin 15.37 11.99 4 504707 0 62984311
Tonsillar neoplasm 15.37 11.99 4 504707 0 62984311
Mastitis 15.36 11.99 51 504660 2581 62981730
Large intestine operation 15.32 11.99 5 504706 6 62984305
Vulval disorder 15.30 11.99 26 504685 846 62983465
Congestive cardiomyopathy 15.19 11.99 16 504695 6166 62978145
Eye infection toxoplasmal 15.18 11.99 15 504696 280 62984031
Acute respiratory distress syndrome 15.17 11.99 117 504594 23417 62960894
Multiple system atrophy 15.14 11.99 13 504698 201 62984110
Squamous cell carcinoma of the vagina 15.13 11.99 6 504705 17 62984294
Epigastric discomfort 15.09 11.99 19 504692 6761 62977550
Ileal ulcer 15.07 11.99 19 504692 469 62983842
Blood urine present 15.06 11.99 65 504646 15004 62969307
Rectal cancer metastatic 15.03 11.99 14 504697 242 62984069
Femoral neck fracture 15.01 11.99 28 504683 8495 62975816
Liver function test abnormal 14.99 11.99 495 504216 47686 62936625
Circumstance or information capable of leading to medication error 14.96 11.99 6 504705 3864 62980447
Intestinal ulcer 14.92 11.99 34 504677 1377 62982934
Blood parathyroid hormone increased 14.89 11.99 3 504708 3035 62981276
Anorectal operation 14.88 11.99 6 504705 18 62984293
Foot deformity 14.75 11.99 307 504404 27546 62956765
Meniscus injury 14.75 11.99 21 504690 7093 62977218
Diverticulum intestinal 14.75 11.99 19 504692 6694 62977617
Eye infection bacterial 14.73 11.99 13 504698 209 62984102
Histone antibody positive 14.69 11.99 9 504702 79 62984232
Rash macular 14.67 11.99 117 504594 23247 62961064
Gastrointestinal stoma complication 14.66 11.99 40 504671 1815 62982496
Nerve block 14.64 11.99 24 504687 758 62983553
Small intestine operation 14.63 11.99 7 504704 35 62984276
Anastomotic ulcer 14.58 11.99 17 504694 386 62983925
Thrombosis in device 14.56 11.99 3 504708 2987 62981324
Cytomegalovirus gastrointestinal infection 14.56 11.99 15 504696 295 62984016
Incoherent 14.53 11.99 9 504702 4521 62979790
Abscess bacterial 14.52 11.99 13 504698 213 62984098
Paranasal sinus hypersecretion 14.48 11.99 6 504705 3789 62980522
Enterocolonic fistula 14.48 11.99 7 504704 36 62984275
Product monitoring error 14.45 11.99 9 504702 4507 62979804
Extranodal marginal zone B-cell lymphoma (MALT type) 14.43 11.99 19 504692 490 62983821
Blood culture positive 14.39 11.99 10 504701 4725 62979586
Embolic stroke 14.36 11.99 6 504705 3770 62980541
Incontinence 14.35 11.99 46 504665 11586 62972725
Blood pressure increased 14.34 11.99 1485 503226 160577 62823734
Drug resistance 14.32 11.99 115 504596 22818 62961493
Diffuse large B-cell lymphoma stage II 14.32 11.99 8 504703 58 62984253
Respiration abnormal 14.26 11.99 18 504693 6399 62977912
Nervous system disorder 14.21 11.99 89 504622 18677 62965634
Overweight 14.20 11.99 6 504705 3745 62980566
Skin induration 14.19 11.99 4 504707 3219 62981092
Anaphylactoid reaction 14.19 11.99 63 504648 3660 62980651
Epstein-Barr virus infection 14.13 11.99 111 504600 7939 62976372
Urine odour abnormal 14.12 11.99 18 504693 6371 62977940
Jaw disorder 14.12 11.99 13 504698 5336 62978975
Respiratory disorder 14.08 11.99 222 504489 38860 62945451
Precancerous cells present 14.04 11.99 34 504677 1433 62982878
Foetal growth restriction 14.04 11.99 24 504687 7529 62976782
Muscle haemorrhage 13.90 11.99 4 504707 3175 62981136
Orbital apex syndrome 13.89 11.99 7 504704 40 62984271
Cytomegalovirus colitis 13.88 11.99 46 504665 2326 62981985
Gingival swelling 13.87 11.99 9 504702 4409 62979902
Application site pain 13.85 11.99 8 504703 4174 62980137
Hydrocephalus 13.85 11.99 13 504698 5287 62979024
Gastrointestinal fistula 13.83 11.99 18 504693 459 62983852
Ileus 13.82 11.99 65 504646 14660 62969651
Ovarian cancer 13.76 11.99 88 504623 5888 62978423
Alopecia universalis 13.73 11.99 10 504701 120 62984191
Sensory disturbance 13.64 11.99 59 504652 13613 62970698
Nail operation 13.63 11.99 25 504686 865 62983446
Seronegative arthritis 13.62 11.99 65 504646 3894 62980417
Ocular icterus 13.60 11.99 6 504705 3650 62980661
Salpingo-oophorectomy 13.59 11.99 6 504705 24 62984287
Abortion incomplete 13.58 11.99 4 504707 3127 62981184
Skin hypertrophy 13.53 11.99 5 504706 3386 62980925
Fluid intake reduced 13.50 11.99 6 504705 3635 62980676
Retinopathy 13.50 11.99 4 504707 3115 62981196
Bacterial translocation 13.49 11.99 13 504698 235 62984076
Faecal calprotectin decreased 13.48 11.99 7 504704 43 62984268
Creatinine urine abnormal 13.48 11.99 7 504704 43 62984268
Red blood cell count increased 13.45 11.99 4 504707 3108 62981203
Coronary arterial stent insertion 13.45 11.99 3 504708 2826 62981485
Psychiatric symptom 13.43 11.99 13 504698 5210 62979101
Laryngeal cancer 13.42 11.99 11 504700 159 62984152
Hyperaemia 13.39 11.99 44 504667 2215 62982096
Lung adenocarcinoma 13.37 11.99 72 504639 4525 62979786
Glossitis 13.25 11.99 4 504707 3078 62981233
Dyspnoea at rest 13.23 11.99 8 504703 4071 62980240
Rectal discharge 13.23 11.99 21 504690 645 62983666
Faecaloma 13.20 11.99 27 504684 7914 62976397
Sickle cell anaemia with crisis 13.18 11.99 17 504694 5986 62978325
Infection in an immunocompromised host 13.17 11.99 22 504689 706 62983605
Endometrial neoplasm 13.16 11.99 4 504707 3 62984308
Respiratory tract carcinoma in situ 13.16 11.99 4 504707 3 62984308
Cytomegalovirus mononucleosis 13.16 11.99 4 504707 3 62984308
Faecal calprotectin 13.16 11.99 4 504707 3 62984308
Atypical mycobacterial lymphadenitis 13.16 11.99 4 504707 3 62984308
Pericarditis lupus 13.16 11.99 4 504707 3 62984308
Drain removal 13.16 11.99 4 504707 3 62984308
Eye swelling 13.14 11.99 124 504587 23794 62960517
Aortic valve incompetence 13.10 11.99 17 504694 5971 62978340
Atypical femur fracture 13.09 11.99 14 504697 5358 62978953
Mood swings 13.08 11.99 88 504623 18160 62966151
Vasculitis necrotising 13.08 11.99 19 504692 539 62983772
White blood cells urine positive 13.07 11.99 13 504698 5145 62979166
Meningitis coccidioides 13.04 11.99 6 504705 27 62984284
Hyperaesthesia 13.00 11.99 35 504676 9323 62974988
Self-medication 12.99 11.99 3 504708 2760 62981551
Vitamin D decreased 12.99 11.99 40 504671 10202 62974109
Cellulitis 12.97 11.99 526 504185 81432 62902879
Scoliosis 12.96 11.99 27 504684 7861 62976450
Superficial spreading melanoma stage unspecified 12.94 11.99 10 504701 132 62984179
Fistulotomy 12.91 11.99 5 504706 13 62984298
Catheter site infection 12.90 11.99 12 504699 4902 62979409
Serum sickness-like reaction 12.89 11.99 18 504693 492 62983819
Polycystic ovaries 12.86 11.99 10 504701 4461 62979850
Hypertension 12.86 11.99 2463 502248 276840 62707471
Odynophagia 12.83 11.99 25 504686 7461 62976850
Atrial tachycardia 12.82 11.99 9 504702 4231 62980080
Malignant melanoma in situ 12.81 11.99 25 504686 907 62983404
Cachexia 12.79 11.99 16 504695 5710 62978601
Bruxism 12.78 11.99 6 504705 3519 62980792
Post procedural inflammation 12.73 11.99 7 504704 49 62984262
Oropharyngeal cancer 12.73 11.99 7 504704 49 62984262
Haemoglobin abnormal 12.69 11.99 13 504698 5075 62979236
Increased appetite 12.65 11.99 37 504674 9593 62974718
Omphalitis 12.64 11.99 9 504702 104 62984207
Hodgkin's disease nodular sclerosis 12.63 11.99 4 504707 4 62984307
Respiratory alkalosis 12.57 11.99 3 504708 2698 62981613
Diabetic neuropathy 12.55 11.99 8 504703 3956 62980355
Adrenal atrophy 12.54 11.99 6 504705 30 62984281
Uterine carcinoma in situ 12.54 11.99 6 504705 30 62984281
Nasopharyngeal cancer 12.54 11.99 6 504705 30 62984281
Thyroidectomy 12.48 11.99 28 504683 1122 62983189
Muscle atrophy 12.48 11.99 23 504688 7010 62977301
Procedural haemorrhage 12.48 11.99 3 504708 2685 62981626
Peripheral coldness 12.45 11.99 52 504659 12113 62972198
Monocyte count increased 12.43 11.99 102 504609 7391 62976920
Blood cholesterol abnormal 12.36 11.99 3 504708 2668 62981643
Tonsil cancer 12.36 11.99 12 504699 219 62984092
Intracranial pressure increased 12.32 11.99 14 504697 5213 62979098
Blood bicarbonate decreased 12.32 11.99 4 504707 2937 62981374
Ligament sprain 12.31 11.99 56 504655 12744 62971567
Foot operation 12.30 11.99 99 504612 7132 62977179
Somatic symptom disorder 12.29 11.99 3 504708 2657 62981654
Ocular sarcoidosis 12.28 11.99 7 504704 53 62984258
Brain herniation 12.23 11.99 7 504704 3670 62980641
Electroencephalogram abnormal 12.20 11.99 7 504704 3665 62980646
Abnormal faeces 12.19 11.99 80 504631 5400 62978911
Jejunectomy 12.17 11.99 4 504707 5 62984306
Cystitis haemorrhagic 12.14 11.99 9 504702 4114 62980197
Neoplasm recurrence 12.14 11.99 3 504708 2635 62981676
Ischaemia 12.12 11.99 12 504699 4760 62979551
Pre-existing condition improved 12.10 11.99 30 504681 8214 62976097
Tuberculosis of eye 12.09 11.99 6 504705 33 62984278
Gait disturbance 12.07 11.99 1273 503438 181905 62802406
Colon injury 12.06 11.99 11 504700 185 62984126
Poor quality product administered 12.02 11.99 5 504706 3151 62981160

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 5859.70 12.22 9223 186628 410301 34350779
Intentional product use issue 4802.19 12.22 3385 192466 56431 34704649
Infusion related reaction 4211.83 12.22 2983 192868 50074 34711006
Inappropriate schedule of product administration 3382.16 12.22 2794 193057 59502 34701578
Product use issue 3166.89 12.22 2707 193144 60509 34700571
Condition aggravated 2529.54 12.22 4135 191716 188061 34573019
Blood pressure fluctuation 1717.31 12.22 1295 194556 23954 34737126
Drug ineffective 1344.79 12.22 5570 190281 451181 34309899
Weight increased 1158.59 12.22 1957 193894 91076 34670004
Drug level below therapeutic 1110.57 12.22 569 195282 5046 34756034
Intestinal resection 1042.15 12.22 386 195465 1363 34759717
Frequent bowel movements 1018.80 12.22 722 195129 12065 34749015
Fistula 1005.12 12.22 569 195282 6271 34754809
Acute kidney injury 987.56 12.22 248 195603 304740 34456340
Haematochezia 964.71 12.22 1245 194606 45289 34715791
Death 921.69 12.22 547 195304 397502 34363578
Tuberculosis 913.39 12.22 580 195271 7997 34753083
Toxicity to various agents 910.68 12.22 53 195798 200309 34560771
Drug specific antibody present 887.47 12.22 412 195439 2873 34758207
Heart rate decreased 875.37 12.22 982 194869 30763 34730317
Drug interaction 866.54 12.22 120 195731 225826 34535254
Arthralgia 786.75 12.22 2412 193439 167629 34593451
Pulmonary tuberculosis 729.73 12.22 407 195444 4347 34756733
Disseminated tuberculosis 711.28 12.22 313 195538 1892 34759188
Therapeutic response shortened 691.08 12.22 461 195390 6943 34754137
Drug level decreased 685.71 12.22 469 195382 7377 34753703
Lupus-like syndrome 668.73 12.22 321 195530 2435 34758645
Faecal calprotectin increased 653.00 12.22 308 195543 2236 34758844
Febrile neutropenia 640.88 12.22 30 195821 136819 34624261
Blood pressure increased 547.89 12.22 1393 194458 86709 34674371
Colectomy 546.23 12.22 247 195604 1607 34759473
Drug abuse 522.81 12.22 6 195845 99090 34661990
Abscess 506.07 12.22 464 195387 11353 34749727
Anal abscess 495.94 12.22 357 195494 6116 34754964
Skin cancer 493.80 12.22 431 195420 9866 34751214
Therapeutic product effect decreased 481.63 12.22 768 195083 33975 34727105
Anaemia 473.80 12.22 369 195482 232966 34528114
Thrombocytopenia 469.26 12.22 146 195705 156101 34604979
Weight decreased 468.06 12.22 2091 193760 174210 34586870
Anal fistula 462.94 12.22 319 195532 5080 34756000
Incorrect dose administered 454.67 12.22 815 195036 39700 34721380
Neutropenia 437.10 12.22 166 195685 156612 34604468
Heart rate irregular 423.59 12.22 482 195369 15325 34745755
Anal fissure 419.44 12.22 275 195576 4015 34757065
Joint swelling 396.28 12.22 970 194881 58920 34702160
Completed suicide 388.04 12.22 47 195804 98121 34662959
Flushing 382.86 12.22 667 195184 31753 34729327
Confusional state 364.53 12.22 176 195675 143984 34617096
Platelet count decreased 359.07 12.22 112 195739 119605 34641475
Apparent death 352.39 12.22 232 195619 3412 34757668
Malignant neoplasm progression 343.46 12.22 44 195807 88002 34673078
Poor venous access 328.19 12.22 255 195596 4928 34756152
Disease progression 327.89 12.22 99 195752 107978 34653102
Synovitis 325.61 12.22 398 195453 13668 34747412
Drug level above therapeutic 321.83 12.22 233 195618 4028 34757052
Hyponatraemia 316.15 12.22 44 195807 82647 34678433
Overdose 313.83 12.22 64 195787 90995 34670085
Treatment failure 312.73 12.22 760 195091 45937 34715143
Urticaria 311.16 12.22 910 194941 61467 34699613
Lymphoma 310.99 12.22 367 195484 12140 34748940
Hyperkalaemia 309.76 12.22 20 195831 69369 34691711
Uveitis 309.30 12.22 289 195562 7246 34753834
Intestinal stenosis 302.72 12.22 175 195676 2011 34759069
Herpes zoster 299.98 12.22 622 195229 33777 34727303
Blood creatinine increased 286.26 12.22 88 195763 94888 34666192
Drug intolerance 281.87 12.22 853 194998 58717 34702363
Clostridium difficile infection 278.79 12.22 430 195421 18468 34742612
Abdominal pain 278.23 12.22 1716 194135 161902 34599178
Cardiac arrest 272.52 12.22 99 195752 96060 34665020
Basal cell carcinoma 271.56 12.22 434 195417 19224 34741856
C-reactive protein abnormal 270.44 12.22 287 195564 8423 34752657
Hypotension 263.56 12.22 528 195323 221121 34539959
Contraindicated product administered 262.79 12.22 449 195402 21032 34740048
Ileal stenosis 261.64 12.22 136 195715 1245 34759835
Renal impairment 260.00 12.22 102 195749 94411 34666669
Body temperature fluctuation 248.42 12.22 140 195711 1527 34759553
Rhabdomyolysis 247.47 12.22 42 195809 68121 34692959
Histoplasmosis 241.26 12.22 133 195718 1385 34759695
Hypersensitivity 240.61 12.22 821 195030 60214 34700866
Somnolence 238.98 12.22 165 195686 110951 34650129
Hypoglycaemia 226.41 12.22 22 195829 54618 34706462
Malignant melanoma 225.76 12.22 252 195599 7838 34753242
Fall 224.63 12.22 503 195348 202382 34558698
Hepatosplenic T-cell lymphoma 223.46 12.22 88 195763 382 34760698
Arthropathy 218.88 12.22 473 195378 26434 34734646
White blood cell count decreased 218.49 12.22 132 195719 95313 34665767
Histoplasmosis disseminated 215.47 12.22 119 195732 1244 34759836
Red blood cell sedimentation rate abnormal 215.20 12.22 171 195680 3418 34757662
Intestinal obstruction 212.37 12.22 424 195427 22398 34738682
Pancytopenia 211.74 12.22 136 195715 95021 34666059
Pyoderma gangrenosum 210.05 12.22 119 195732 1312 34759768
Pneumonia legionella 209.97 12.22 131 195720 1746 34759334
Atrial fibrillation 208.31 12.22 227 195624 122166 34638914
Hallucination 207.53 12.22 23 195828 51475 34709605
International normalised ratio increased 207.23 12.22 15 195836 47312 34713768
Lymph node tuberculosis 206.91 12.22 83 195768 382 34760698
Intentional overdose 206.11 12.22 9 195842 43665 34717415
Cardio-respiratory arrest 205.24 12.22 32 195819 55241 34705839
Nephrolithiasis 203.34 12.22 494 195357 29839 34731241
Seizure 199.77 12.22 176 195675 104681 34656399
Neutrophil count decreased 198.12 12.22 26 195825 51078 34710002
Cardiac failure congestive 197.92 12.22 110 195741 83160 34677920
Cardiac failure 190.26 12.22 140 195711 91108 34669972
Diverticulitis 184.15 12.22 370 195481 19634 34741446
Colitis ulcerative 183.50 12.22 331 195520 16189 34744891
Blood glucose increased 183.44 12.22 72 195779 66646 34694434
Metabolic acidosis 182.52 12.22 17 195834 43663 34717417
Large intestinal stenosis 179.43 12.22 111 195740 1456 34759624
Weight fluctuation 179.25 12.22 181 195670 5004 34756076
Electrocardiogram QT prolonged 179.24 12.22 13 195838 40939 34720141
Mucous stools 176.30 12.22 115 195736 1663 34759417
Delirium 171.44 12.22 22 195829 43969 34717111
Gastrointestinal haemorrhage 170.33 12.22 147 195704 88330 34672750
Drug specific antibody 169.34 12.22 66 195785 277 34760803
Lactic acidosis 168.02 12.22 6 195845 34766 34726314
Body temperature decreased 165.43 12.22 277 195574 12757 34748323
Diarrhoea haemorrhagic 164.04 12.22 196 195655 6568 34754512
COVID-19 163.50 12.22 862 194989 76688 34684392
Constipation 161.13 12.22 328 195523 136654 34624426
Erythema 160.69 12.22 947 194904 87833 34673247
Hypokalaemia 159.74 12.22 63 195788 58151 34702929
Coma 157.51 12.22 32 195819 45646 34715434
Fistula discharge 157.09 12.22 83 195768 788 34760292
Respiratory failure 156.92 12.22 228 195623 108344 34652736
Arthritis 156.84 12.22 458 195393 30888 34730192
Bradycardia 156.83 12.22 116 195735 75302 34685778
Infusion site extravasation 154.50 12.22 154 195697 4190 34756890
Defaecation urgency 152.34 12.22 122 195729 2467 34758613
Bone erosion 151.48 12.22 147 195704 3868 34757212
Mycobacterium marinum infection 149.64 12.22 58 195793 239 34760841
Therapeutic product effect incomplete 148.56 12.22 619 195232 49922 34711158
Meningitis listeria 148.25 12.22 67 195784 435 34760645
Erythema nodosum 147.69 12.22 94 195757 1300 34759780
Neoplasm malignant 147.33 12.22 337 195514 19568 34741512
Hyperglycaemia 146.23 12.22 23 195828 39457 34721623
Loss of personal independence in daily activities 145.61 12.22 463 195388 32716 34728364
Ileostomy 145.27 12.22 73 195778 618 34760462
Neuropathy peripheral 144.30 12.22 152 195699 83111 34677969
Systemic lupus erythematosus 141.73 12.22 137 195714 3587 34757493
Depressed level of consciousness 141.65 12.22 33 195818 42808 34718272
Decreased appetite 140.90 12.22 470 195381 165922 34595158
Musculoskeletal stiffness 138.20 12.22 573 195278 46107 34714973
Drug reaction with eosinophilia and systemic symptoms 137.51 12.22 13 195838 32999 34728081
Colectomy total 136.89 12.22 48 195803 138 34760942
Mental status changes 134.85 12.22 25 195826 38058 34723022
Tuberculous pleurisy 134.65 12.22 58 195793 330 34760750
Disorientation 133.25 12.22 15 195836 33173 34727907
Asthenia 131.03 12.22 821 195030 244430 34516650
Aggression 130.85 12.22 29 195822 38935 34722145
Chest discomfort 130.28 12.22 628 195223 53902 34707178
Disability 128.80 12.22 146 195705 4619 34756461
Surgery 128.08 12.22 260 195591 13897 34747183
Blood urea increased 126.36 12.22 12 195839 30352 34730728
Hodgkin's disease 125.92 12.22 72 195779 809 34760271
Inflammation 125.21 12.22 396 195455 27899 34733181
Acute myocardial infarction 124.69 12.22 73 195778 53646 34707434
Oedema peripheral 122.87 12.22 309 195542 119503 34641577
Antinuclear antibody positive 122.71 12.22 84 195767 1322 34759758
Intentional product misuse 122.46 12.22 51 195800 45560 34715520
Peritoneal tuberculosis 121.01 12.22 53 195798 316 34760764
Vein rupture 120.82 12.22 71 195780 843 34760237
Pneumonia aspiration 120.58 12.22 42 195809 41861 34719219
Malaise 119.68 12.22 1577 194274 184248 34576832
Rectal abscess 118.95 12.22 82 195769 1306 34759774
Squamous cell carcinoma 118.71 12.22 223 195628 11252 34749828
Psoriasis 118.49 12.22 481 195370 38331 34722749
Dehydration 118.49 12.22 355 195496 129614 34631466
Hypoxia 118.11 12.22 82 195769 55013 34706067
Plasma cell myeloma 117.80 12.22 44 195807 41993 34719087
Impaired quality of life 117.76 12.22 154 195697 5664 34755416
Encephalopathy 117.18 12.22 27 195824 35292 34725788
Rheumatoid factor negative 116.64 12.22 69 195782 830 34760250
Aphthous ulcer 115.03 12.22 141 195710 4854 34756226
Cytokine release syndrome 113.95 12.22 3 195848 22874 34738206
Agitation 113.34 12.22 93 195758 57306 34703774
Suicide attempt 111.20 12.22 40 195811 39076 34722004
Exposure to SARS-CoV-2 111.05 12.22 56 195795 478 34760602
Drug hypersensitivity 110.84 12.22 802 195049 79727 34681353
Red blood cell sedimentation rate increased 108.73 12.22 189 195662 8973 34752107
Acne 108.25 12.22 210 195641 10856 34750224
Lymphoproliferative disorder 107.83 12.22 103 195748 2656 34758424
Inflammatory bowel disease 106.59 12.22 105 195746 2815 34758265
Therapeutic response decreased 106.51 12.22 384 195467 28929 34732151
Drug eruption 105.59 12.22 297 195554 19601 34741479
Knee arthroplasty 103.67 12.22 165 195686 7279 34753801
Orthostatic hypotension 103.34 12.22 12 195839 25907 34735173
Ascites 102.93 12.22 67 195784 46504 34714576
Hypomagnesaemia 101.47 12.22 5 195846 21846 34739234
Memory impairment 100.34 12.22 59 195792 43259 34717821
Bone cyst 99.73 12.22 78 195773 1522 34759558
Dizziness 98.69 12.22 768 195083 217753 34543327
C-reactive protein increased 98.41 12.22 578 195273 53520 34707560
Blood pressure diastolic decreased 98.17 12.22 180 195671 8914 34752166
Mucosal inflammation 97.69 12.22 47 195804 38575 34722505
Blood creatine phosphokinase increased 97.16 12.22 66 195785 44791 34716289
Sedation 96.93 12.22 5 195846 21001 34740079
Haematuria 96.53 12.22 83 195768 49983 34711097
Non-Hodgkin's lymphoma 96.48 12.22 75 195776 1450 34759630
Incorrect drug administration rate 95.36 12.22 78 195773 1627 34759453
Henoch-Schonlein purpura 94.99 12.22 77 195774 1585 34759495
Sarcoidosis 94.71 12.22 98 195753 2790 34758290
Gastrointestinal inflammation 93.92 12.22 107 195744 3404 34757676
Intestinal operation 93.68 12.22 39 195812 201 34760879
Rheumatoid arthritis 93.21 12.22 443 195408 37795 34723285
Cardiogenic shock 93.12 12.22 18 195833 26600 34734480
Pouchitis 92.19 12.22 54 195797 637 34760443
Aspartate aminotransferase increased 91.50 12.22 149 195702 67634 34693446
Chronic kidney disease 91.46 12.22 59 195792 41151 34719929
Pulmonary oedema 91.38 12.22 79 195772 47450 34713630
Feeling hot 91.14 12.22 277 195574 19095 34741985
Haemoglobin decreased 91.00 12.22 358 195493 120414 34640666
Cutaneous leishmaniasis 90.93 12.22 37 195814 178 34760902
Oropharyngeal pain 90.82 12.22 417 195434 35068 34726012
Pain 90.20 12.22 1629 194222 203046 34558034
Leukopenia 89.78 12.22 133 195718 62723 34698357
Coronary artery disease 89.63 12.22 83 195768 48222 34712858
Atlantoaxial instability 89.24 12.22 42 195809 303 34760777
Listeriosis 88.19 12.22 61 195790 977 34760103
Altered state of consciousness 87.87 12.22 12 195839 22881 34738199
Neoplasm progression 87.59 12.22 13 195838 23287 34737793
Chondropathy 87.14 12.22 59 195792 911 34760169
Hypervolaemia 86.98 12.22 6 195845 19703 34741377
Rectal haemorrhage 86.55 12.22 450 195401 39799 34721281
Respiratory arrest 86.21 12.22 25 195826 28018 34733062
Cerebrovascular accident 85.92 12.22 220 195631 84591 34676489
Hepatic failure 85.86 12.22 43 195808 34488 34726592
Wrong technique in product usage process 84.79 12.22 48 195803 35938 34725142
Full blood count decreased 84.44 12.22 4 195847 18084 34742996
Suicidal ideation 84.08 12.22 62 195789 40326 34720754
Alanine aminotransferase abnormal 84.08 12.22 117 195734 4571 34756509
Alanine aminotransferase increased 83.92 12.22 207 195644 80608 34680472
Toxic epidermal necrolysis 83.90 12.22 11 195840 21635 34739445
Cognitive disorder 83.87 12.22 28 195823 28665 34732415
Hypocalcaemia 83.76 12.22 17 195834 24272 34736808
Dysphagia 83.38 12.22 138 195713 62243 34698837
Urinary retention 83.23 12.22 50 195801 36238 34724842
Blood bilirubin increased 82.07 12.22 57 195794 38239 34722841
Small intestinal resection 81.59 12.22 45 195806 469 34760611
Ventricular fibrillation 81.41 12.22 15 195836 22939 34738141
Spinal instability 80.99 12.22 40 195811 325 34760755
Fatigue 80.95 12.22 1527 194324 369126 34391954
Multiple organ dysfunction syndrome 80.38 12.22 195 195656 76371 34684709
Cerebral haemorrhage 80.33 12.22 48 195803 34889 34726191
Jaundice 80.33 12.22 39 195812 31843 34729237
Mineral metabolism disorder 80.27 12.22 40 195811 332 34760748
Lung neoplasm malignant 80.22 12.22 247 195604 17148 34743932
B-cell lymphoma 79.91 12.22 110 195741 4253 34756827
Drug tolerance decreased 79.86 12.22 75 195776 1892 34759188
Legionella infection 79.74 12.22 44 195807 459 34760621
Dysarthria 79.67 12.22 48 195803 34734 34726346
Ileectomy 79.58 12.22 24 195827 34 34761046
Enthesopathy 78.10 12.22 112 195739 4501 34756579
Rash maculo-papular 77.68 12.22 31 195820 28420 34732660
Subdural haematoma 77.68 12.22 11 195840 20410 34740670
Ventricular tachycardia 77.57 12.22 26 195825 26553 34734527
Cholangitis sclerosing 77.36 12.22 64 195787 1357 34759723
Dislocation of vertebra 77.00 12.22 41 195810 396 34760684
Unresponsive to stimuli 76.99 12.22 29 195822 27540 34733540
Loss of therapeutic response 76.73 12.22 46 195805 568 34760512
Hypophagia 76.49 12.22 20 195831 24002 34737078
Haemoptysis 76.49 12.22 51 195800 34955 34726125
Blood pressure diastolic increased 76.42 12.22 116 195735 4909 34756171
IgA nephropathy 75.34 12.22 60 195791 1203 34759877
Gamma-glutamyltransferase increased 74.80 12.22 35 195816 29196 34731884
Type IV hypersensitivity reaction 74.79 12.22 63 195788 1371 34759709
Enterostomy 74.73 12.22 27 195824 87 34760993
Drug withdrawal syndrome 74.71 12.22 11 195840 19823 34741257
Dry mouth 74.34 12.22 38 195813 30127 34730953
Pulmonary thrombosis 74.21 12.22 142 195709 7265 34753815
Irritability 74.10 12.22 23 195828 24667 34736413
Full blood count abnormal 73.54 12.22 9 195842 18659 34742421
Stevens-Johnson syndrome 73.39 12.22 9 195842 18630 34742450
Blood alkaline phosphatase increased 72.85 12.22 42 195809 31133 34729947
Pleural effusion 71.93 12.22 226 195625 81320 34679760
Pneumonia 71.32 12.22 1520 194331 361107 34399973
Upper gastrointestinal haemorrhage 71.00 12.22 27 195824 25491 34735589
Tumour lysis syndrome 70.30 12.22 7 195844 17052 34744028
Injection site pain 70.04 12.22 69 195782 38936 34722144
Haemorrhage intracranial 69.94 12.22 5 195846 15941 34745139
Joint ankylosis 69.77 12.22 63 195788 1509 34759571
Angioedema 69.59 12.22 64 195787 37310 34723770
Proctocolectomy 69.50 12.22 26 195825 95 34760985
Perirectal abscess 69.43 12.22 65 195786 1633 34759447
Hallucination, visual 69.06 12.22 9 195842 17782 34743298
Illness 68.92 12.22 199 195652 13330 34747750
Dyskinesia 68.86 12.22 20 195831 22393 34738687
Cytomegalovirus colitis 68.04 12.22 81 195770 2703 34758377
Accidental overdose 67.59 12.22 15 195836 20125 34740955
Fluid retention 67.57 12.22 33 195818 26854 34734226
Depression 67.41 12.22 297 195554 96801 34664279
Tenosynovitis 67.39 12.22 104 195747 4466 34756614
Blood pressure systolic increased 67.31 12.22 281 195570 22671 34738409
Onychoclasis 66.91 12.22 67 195784 1833 34759247
Contraindication to vaccination 66.90 12.22 18 195833 11 34761069
Agranulocytosis 66.62 12.22 25 195826 23796 34737284
Balance disorder 66.24 12.22 78 195773 40576 34720504
Impaired work ability 65.94 12.22 130 195721 6800 34754280
Pericarditis 65.93 12.22 178 195673 11467 34749613
Heart rate increased 65.72 12.22 465 195386 45878 34715202
Diabetic ketoacidosis 65.66 12.22 11 195840 18021 34743059
Septic shock 65.55 12.22 196 195655 71638 34689442
Pulmonary hypertension 65.53 12.22 18 195833 20906 34740174
Melaena 65.38 12.22 61 195790 35319 34725761
Myelosuppression 65.36 12.22 14 195837 19251 34741829
Product quality issue 65.21 12.22 9 195842 17026 34744054
Colon cancer 64.94 12.22 147 195704 8474 34752606
Eosinophilia 64.67 12.22 33 195818 26189 34734891
Pneumocystis jirovecii pneumonia 63.94 12.22 249 195602 19461 34741619
Diarrhoea 63.74 12.22 1681 194170 388231 34372849
Chronic obstructive pulmonary disease 63.72 12.22 110 195741 48808 34712272
Throat tightness 63.49 12.22 143 195708 8215 34752865
Proctectomy 63.07 12.22 24 195827 93 34760987
Osteonecrosis of jaw 62.78 12.22 12 195839 17877 34743203
Insomnia 62.74 12.22 334 195517 103573 34657507
Blood potassium increased 62.47 12.22 9 195842 16486 34744594
Ischaemic stroke 62.46 12.22 13 195838 18237 34742843
Abnormal behaviour 62.21 12.22 31 195820 24938 34736142
Disturbance in attention 62.00 12.22 34 195817 25911 34735169
Lethargy 61.69 12.22 84 195767 41038 34720042
Urinary tract infection 61.55 12.22 252 195599 83829 34677251
Psychotic disorder 61.46 12.22 30 195821 24422 34736658
Neurotoxicity 61.28 12.22 13 195838 17997 34743083
Pallor 61.21 12.22 294 195557 25186 34735894
Mass 60.89 12.22 136 195715 7769 34753311
Iritis 60.54 12.22 56 195795 1385 34759695
Serum sickness 60.48 12.22 65 195786 1935 34759145
Haematocrit decreased 60.18 12.22 55 195796 32161 34728919
Extrapulmonary tuberculosis 59.74 12.22 22 195829 76 34761004
Bone marrow failure 59.48 12.22 46 195805 29207 34731873
Faeces soft 59.14 12.22 85 195766 3423 34757657
Joint lock 58.37 12.22 52 195799 1223 34759857
Myoclonus 58.25 12.22 7 195844 14718 34746362
Therapy interrupted 58.10 12.22 5 195846 13692 34747388
Oedema 57.64 12.22 105 195746 45636 34715444
Dyspnoea exertional 57.58 12.22 96 195755 43183 34717897
Acute respiratory failure 57.53 12.22 53 195798 30875 34730205
Syncope 57.44 12.22 290 195561 91161 34669919
Withdrawal syndrome 57.35 12.22 3 195848 12452 34748628
Anal stenosis 57.25 12.22 26 195825 171 34760909
Myocardial infarction 57.19 12.22 420 195431 120665 34640415
Labelled drug-drug interaction medication error 56.93 12.22 8 195843 14931 34746149
Pregnancy of partner 56.88 12.22 31 195820 315 34760765
Sepsis 56.70 12.22 628 195223 165933 34595147
Psoriatic arthropathy 56.20 12.22 240 195611 19558 34741522
Sinus tachycardia 56.14 12.22 14 195837 17346 34743734
Vomiting 56.14 12.22 1013 194838 246608 34514472
Poisoning 56.12 12.22 3 195848 12223 34748857
Salmonellosis 56.09 12.22 46 195805 963 34760117
Dysgeusia 56.03 12.22 40 195811 26457 34734623
Terminal state 55.88 12.22 88 195763 3846 34757234
Infected fistula 55.87 12.22 25 195826 158 34760922
Haematemesis 55.81 12.22 44 195807 27667 34733413
White coat hypertension 55.74 12.22 25 195826 159 34760921
Hyperbilirubinaemia 55.61 12.22 13 195838 16830 34744250
Obstructive airways disorder 55.21 12.22 10 195841 15484 34745596
Renal failure 55.09 12.22 467 195384 130090 34630990
No adverse event 54.85 12.22 30 195821 22897 34738183
Sinus bradycardia 54.26 12.22 5 195846 12958 34748122
Glomerular filtration rate decreased 54.25 12.22 5 195846 12956 34748124
Demyelination 54.23 12.22 78 195773 3143 34757937
Brain oedema 53.62 12.22 7 195844 13814 34747266
Gait disturbance 53.46 12.22 270 195581 84870 34676210
Intentional self-injury 53.37 12.22 7 195844 13764 34747316
Ankylosing spondylitis 53.17 12.22 105 195746 5499 34755581
Loss of consciousness 53.14 12.22 260 195591 82407 34678673
Drug level abnormal 52.93 12.22 25 195826 182 34760898
Multiple sclerosis relapse 52.55 12.22 6 195845 13127 34747953
Pustular psoriasis 52.47 12.22 55 195796 1590 34759490
Joint arthroplasty 52.45 12.22 42 195809 849 34760231
Abscess intestinal 52.44 12.22 55 195796 1591 34759489
Ileocaecal resection 52.31 12.22 18 195833 48 34761032
Coagulopathy 51.71 12.22 23 195828 19766 34741314
Small intestinal obstruction 51.67 12.22 192 195659 14674 34746406
Joint stiffness 51.63 12.22 156 195695 10717 34750363
Small intestinal stenosis 51.63 12.22 34 195817 500 34760580
Unevaluable event 51.53 12.22 64 195787 32526 34728554
Speech disorder 51.46 12.22 41 195810 25645 34735435
Angina pectoris 51.28 12.22 60 195791 31303 34729777
Haematoma 51.13 12.22 41 195810 25564 34735516
Ileostomy closure 51.02 12.22 18 195833 53 34761027
Respiratory depression 50.82 12.22 14 195837 16231 34744849
Steroid dependence 50.69 12.22 52 195799 1465 34759615
Colostomy 50.42 12.22 33 195818 480 34760600
Hepatotoxicity 50.12 12.22 29 195822 21456 34739624
Intestinal fistula 50.05 12.22 43 195808 962 34760118
Pseudopolyp 49.91 12.22 25 195826 210 34760870
Pharyngitis streptococcal 49.65 12.22 68 195783 2616 34758464
Enterovesical fistula 49.39 12.22 39 195812 772 34760308
Faecal calprotectin abnormal 49.22 12.22 25 195826 217 34760863
Hepatic encephalopathy 49.15 12.22 11 195840 14674 34746406
Coccidioidomycosis 49.13 12.22 38 195813 729 34760351
Intestinal sepsis 49.10 12.22 36 195815 635 34760445
Tuberculosis gastrointestinal 49.02 12.22 25 195826 219 34760861
Troponin increased 48.74 12.22 4 195847 11385 34749695
Oxygen saturation abnormal 48.53 12.22 51 195800 1479 34759601
Cutaneous T-cell lymphoma 48.31 12.22 51 195800 1487 34759593
T-cell lymphoma 48.18 12.22 42 195809 959 34760121
Erectile dysfunction 47.93 12.22 28 195823 20609 34740471
Tooth loss 47.63 12.22 81 195770 3777 34757303
Ear infection bacterial 47.62 12.22 12 195839 3 34761077
Subarachnoid haemorrhage 47.60 12.22 7 195844 12628 34748452
Delusion 47.60 12.22 7 195844 12628 34748452
Antinuclear antibody increased 47.53 12.22 28 195823 334 34760746
Hip arthroplasty 47.52 12.22 88 195763 4391 34756689
Anti-cyclic citrullinated peptide antibody positive 47.33 12.22 55 195796 1788 34759292
Bladder transitional cell carcinoma 47.22 12.22 66 195785 2589 34758491
Rectal cancer 47.14 12.22 60 195791 2147 34758933
Blood lactate dehydrogenase increased 46.94 12.22 36 195815 22954 34738126
Tongue neoplasm malignant stage unspecified 46.53 12.22 35 195816 643 34760437
Hyperlipidaemia 46.44 12.22 12 195839 14517 34746563
Pyrexia 46.43 12.22 1467 194384 331546 34429534
Hepatocellular injury 46.35 12.22 34 195817 22177 34738903
Anuria 46.30 12.22 3 195848 10382 34750698
Blood cholesterol increased 46.14 12.22 29 195822 20514 34740566
Rectal tenesmus 45.61 12.22 38 195813 814 34760266
Polyarthritis 45.43 12.22 87 195764 4453 34756627
Clear cell renal cell carcinoma 45.17 12.22 43 195808 1104 34759976
Red blood cell count decreased 45.08 12.22 58 195793 29032 34732048
Hypothyroidism 44.92 12.22 31 195820 20871 34740209
Cytology abnormal 44.89 12.22 28 195823 373 34760707
Tongue disorder 44.71 12.22 95 195756 5244 34755836
Restlessness 44.69 12.22 46 195805 25436 34735644
Skin laceration 44.69 12.22 163 195688 12346 34748734
Stoma creation 44.46 12.22 14 195837 25 34761055
Testicular seminoma (pure) 44.18 12.22 16 195835 52 34761028
Throat irritation 43.96 12.22 145 195706 10440 34750640
Therapy cessation 43.93 12.22 20 195831 16953 34744127
Blood sodium decreased 43.88 12.22 18 195833 16233 34744847
Tooth fracture 43.70 12.22 76 195775 3609 34757471
Aspiration 43.17 12.22 8 195843 12186 34748894
Venous injury 43.11 12.22 25 195826 289 34760791
Abdominal abscess 43.01 12.22 81 195770 4094 34756986
Wheezing 42.99 12.22 106 195745 41296 34719784
Renal tubular necrosis 42.94 12.22 17 195834 15663 34745417
Neutropenic sepsis 42.82 12.22 12 195839 13755 34747325
Cell marker increased 42.74 12.22 28 195823 408 34760672
Renal injury 42.65 12.22 6 195845 11189 34749891
Atrial flutter 42.46 12.22 17 195834 15557 34745523
Pelvic abscess 42.40 12.22 38 195813 901 34760179
Intervertebral disc space narrowing 42.40 12.22 40 195811 1015 34760065
Depressed mood 42.39 12.22 28 195823 19289 34741791
Cerebral infarction 42.28 12.22 55 195796 27400 34733680
Wisdom teeth removal 41.99 12.22 18 195833 101 34760979
Tooth infection 41.90 12.22 107 195744 6664 34754416
Hypophosphataemia 41.79 12.22 6 195845 11020 34750060
Miosis 41.79 12.22 3 195848 9532 34751548
Bladder neoplasm 41.78 12.22 45 195806 1343 34759737
Arthritis bacterial 41.77 12.22 90 195761 5016 34756064
Urine output decreased 41.73 12.22 4 195847 10045 34751035
Circulatory collapse 41.62 12.22 34 195817 21004 34740076
Cholestasis 41.48 12.22 54 195797 26894 34734186
Pericarditis tuberculous 41.27 12.22 16 195835 66 34761014
Anal cancer 41.21 12.22 28 195823 435 34760645
Glycosylated haemoglobin increased 41.20 12.22 7 195844 11353 34749727
Chills 41.02 12.22 660 195191 80383 34680697
Nephropathy toxic 41.00 12.22 10 195841 12578 34748502
Dystonia 40.88 12.22 6 195845 10839 34750241
Sinusitis bacterial 40.72 12.22 28 195823 444 34760636
Anaphylactic reaction 40.60 12.22 315 195536 31986 34729094
Device issue 40.32 12.22 4 195847 9773 34751307
Mobility decreased 40.22 12.22 298 195553 29830 34731250
Lymphocyte count decreased 39.49 12.22 41 195810 22581 34738499
Prostate cancer 39.45 12.22 367 195484 39282 34721798
Gastrointestinal infection 39.44 12.22 95 195756 5703 34755377
Leukocytosis 39.38 12.22 46 195805 24019 34737061
Body temperature increased 39.28 12.22 197 195654 17171 34743909
Intestinal ulcer 39.20 12.22 36 195815 882 34760198
Colon dysplasia 39.18 12.22 18 195833 122 34760958
Tuberculin test positive 38.99 12.22 40 195811 1127 34759953
Acute hepatic failure 38.97 12.22 15 195836 14059 34747021
Latent tuberculosis 38.96 12.22 43 195808 1320 34759760
Transient ischaemic attack 38.85 12.22 59 195792 27554 34733526
Infectious mononucleosis 38.78 12.22 31 195820 625 34760455
Suspected COVID-19 38.76 12.22 41 195810 1198 34759882
Colitis 38.35 12.22 351 195500 37399 34723681
Osteosclerosis 38.24 12.22 42 195809 1282 34759798
Product administration error 38.21 12.22 22 195829 16322 34744758
Transplant rejection 38.19 12.22 6 195845 10305 34750775
Renal cell carcinoma 37.93 12.22 86 195765 4962 34756118
Ejection fraction decreased 37.83 12.22 31 195820 19123 34741957
Listeria sepsis 37.79 12.22 19 195832 161 34760919
Aplastic anaemia 37.50 12.22 5 195846 9711 34751369
Neutrophil count increased 37.42 12.22 25 195826 17121 34743959
Generalised tonic-clonic seizure 37.39 12.22 38 195813 21136 34739944
Activated partial thromboplastin time prolonged 37.36 12.22 3 195848 8692 34752388
Atelectasis 37.16 12.22 27 195824 17700 34743380
Contusion 37.05 12.22 94 195757 36270 34724810
Proctalgia 37.05 12.22 92 195759 5631 34755449
Blood uric acid increased 37.04 12.22 5 195846 9619 34751461
Rectal stenosis 36.82 12.22 19 195832 171 34760909
Appendicectomy 36.66 12.22 38 195813 1084 34759996
Paranoia 36.65 12.22 11 195840 12057 34749023
Varicella 36.47 12.22 46 195805 1631 34759449
Colostomy closure 36.43 12.22 13 195838 40 34761040
Ataxia 36.36 12.22 16 195835 13837 34747243
Physical disability 36.35 12.22 42 195809 1357 34759723
Cytomegalovirus infection 36.32 12.22 261 195590 25874 34735206
Cardiac disorder 36.29 12.22 122 195729 43004 34718076
Hypernatraemia 36.28 12.22 3 195848 8487 34752593
Pneumonia cryptococcal 35.81 12.22 34 195817 870 34760210
Cardiomegaly 35.78 12.22 21 195830 15417 34745663
Gastric haemorrhage 35.76 12.22 7 195844 10254 34750826
Acute pulmonary histoplasmosis 35.56 12.22 18 195833 155 34760925
Double stranded DNA antibody 35.53 12.22 11 195840 18 34761062
Urinary incontinence 35.51 12.22 32 195819 18842 34742238
Ankle deformity 35.26 12.22 20 195831 221 34760859
Diffuse large B-cell lymphoma 35.24 12.22 106 195745 7264 34753816
Fistula repair 35.03 12.22 10 195841 10 34761070
Pulmonary arterial hypertension 34.95 12.22 4 195847 8735 34752345
Hiccups 34.88 12.22 7 195844 10075 34751005
Haemodynamic instability 34.25 12.22 6 195845 9517 34751563
White blood cell count increased 34.23 12.22 117 195734 41034 34720046
Pneumonitis 34.19 12.22 88 195763 33790 34727290
Mania 34.19 12.22 6 195845 9505 34751575
Subcutaneous abscess 34.07 12.22 70 195781 3773 34757307
Mental impairment 34.01 12.22 8 195843 10314 34750766
Hand fracture 33.90 12.22 51 195800 2141 34758939
Ophthalmic herpes zoster 33.79 12.22 33 195818 875 34760205
Anxiety 33.74 12.22 375 195476 99053 34662027
Proctitis 33.71 12.22 54 195797 2395 34758685
Product dose omission issue 33.68 12.22 470 195381 119241 34641839
Prothrombin time prolonged 33.67 12.22 6 195845 9400 34751680
Injection site erythema 33.61 12.22 24 195827 15875 34745205
Muscular weakness 33.37 12.22 255 195596 72642 34688438
Sports injury 33.36 12.22 16 195835 121 34760959
Thyroid cancer 33.27 12.22 44 195807 1636 34759444
Product prescribing error 33.22 12.22 48 195803 22879 34738201
Vasectomy 33.14 12.22 12 195839 39 34761041
Haemodialysis 33.06 12.22 9 195842 10517 34750563
Blood calcium decreased 32.87 12.22 8 195843 10076 34751004
Nightmare 32.76 12.22 20 195831 14371 34746709
Respiratory distress 32.74 12.22 97 195754 35568 34725512
Dermatitis psoriasiform 32.47 12.22 41 195810 1455 34759625
Mitral valve incompetence 32.33 12.22 22 195829 14921 34746159
Drug use disorder 32.16 12.22 72 195779 4119 34756961
Erythrodermic psoriasis 31.97 12.22 32 195819 875 34760205
Pathogen resistance 31.94 12.22 7 195844 9475 34751605
Chromaturia 31.92 12.22 21 195830 14499 34746581
Treatment noncompliance 31.54 12.22 69 195782 28031 34733049
Inappropriate antidiuretic hormone secretion 31.52 12.22 16 195835 12737 34748343
Serum sickness-like reaction 31.49 12.22 16 195835 139 34760941
Acidosis 31.43 12.22 11 195840 10934 34750146
Exposure during pregnancy 31.33 12.22 6 195845 8928 34752152
Anorectal disorder 31.13 12.22 35 195816 1097 34759983
Therapy non-responder 31.10 12.22 346 195505 38800 34722280
Dyspnoea 31.08 12.22 1761 194090 375021 34386059
Arrhythmia 31.02 12.22 100 195751 35708 34725372
Aphasia 31.00 12.22 45 195806 21409 34739671
Wrist fracture 30.66 12.22 45 195806 1847 34759233
Psychomotor hyperactivity 30.65 12.22 8 195843 9614 34751466
Cyst 30.60 12.22 74 195777 4454 34756626
DNA antibody positive 30.31 12.22 12 195839 53 34761027
Diabetes mellitus inadequate control 30.24 12.22 19 195832 13445 34747635
Renal colic 30.18 12.22 44 195807 1795 34759285
Epstein-Barr virus associated lymphoma 30.10 12.22 27 195824 641 34760439
Angina unstable 29.74 12.22 14 195837 11639 34749441
Eosinophil count increased 29.55 12.22 6 195845 8566 34752514
Muscle rigidity 29.47 12.22 11 195840 10507 34750573
Polychondritis 29.36 12.22 18 195833 232 34760848
Injury 29.30 12.22 44 195807 20643 34740437
Lymphopenia 29.20 12.22 29 195822 16306 34744774
Shock 29.14 12.22 57 195794 24122 34736958
Rheumatoid factor positive 28.92 12.22 27 195824 676 34760404
Tonsillitis 28.87 12.22 50 195801 2366 34758714
Stress 28.74 12.22 278 195573 30069 34731011
Peritonsillar abscess 28.61 12.22 21 195830 371 34760709
Episcleritis 28.43 12.22 16 195835 174 34760906
COVID-19 pneumonia 28.23 12.22 32 195819 16935 34744145
Cardiac failure acute 28.07 12.22 12 195839 10558 34750522
Myelodysplastic syndrome 28.04 12.22 40 195811 19168 34741912
Drug ineffective for unapproved indication 28.01 12.22 228 195623 23487 34737593
Nasopharyngitis 27.98 12.22 549 195302 69419 34691661
Nasal congestion 27.95 12.22 223 195628 22834 34738246
Neoplasm prostate 27.91 12.22 18 195833 255 34760825
Salivary hypersecretion 27.89 12.22 7 195844 8637 34752443
Tricuspid valve incompetence 27.70 12.22 10 195841 9750 34751330
Medication error 27.69 12.22 64 195787 25501 34735579
Oligoarthritis 27.52 12.22 14 195837 122 34760958
Parkinsonism 27.43 12.22 6 195845 8132 34752948
Epilepsy 27.38 12.22 49 195802 21446 34739634
Lung neoplasm 27.24 12.22 72 195779 4579 34756501
Cutaneous lymphoma 27.14 12.22 13 195838 98 34760982
Substance abuse 27.08 12.22 5 195846 7636 34753444
Adenocarcinoma 27.01 12.22 43 195808 1897 34759183
Hypovolaemia 27.00 12.22 9 195842 9225 34751855
Epstein-Barr virus infection 26.91 12.22 99 195752 7529 34753551
Pyoderma 26.85 12.22 14 195837 129 34760951
Vein collapse 26.82 12.22 15 195836 161 34760919
Thrombotic microangiopathy 26.78 12.22 13 195838 10617 34750463
Pollakiuria 26.76 12.22 43 195808 19631 34741449
Crohn's disease 26.72 12.22 56 195795 3061 34758019
Status epilepticus 26.72 12.22 19 195832 12595 34748485
Seronegative arthritis 26.67 12.22 31 195820 1008 34760072
Intestinal perforation 26.62 12.22 111 195740 8949 34752131
Injection site papule 26.56 12.22 19 195832 322 34760758
Hyperthyroidism 26.50 12.22 13 195838 10553 34750527
Antibody test abnormal 26.38 12.22 16 195835 202 34760878
Osteolysis 26.34 12.22 56 195795 3092 34757988
Drug specific antibody absent 26.29 12.22 12 195839 80 34761000
Sacroiliitis 26.29 12.22 37 195814 1461 34759619
Infusion site pain 26.09 12.22 63 195788 3788 34757292
Injection site reaction 25.86 12.22 21 195830 13012 34748068
Listeria encephalitis 25.84 12.22 10 195841 41 34761039
Blood loss anaemia 25.75 12.22 7 195844 8187 34752893
Hidradenitis 25.65 12.22 31 195820 1051 34760029
Left ventricular dysfunction 25.57 12.22 12 195839 9995 34751085
Plasmablastic lymphoma 25.31 12.22 19 195832 348 34760732
Electrolyte imbalance 25.29 12.22 26 195825 14386 34746694
Stomatitis 25.29 12.22 356 195495 42158 34718922
Small intestine carcinoma 25.28 12.22 24 195827 614 34760466
Hyperammonaemia 25.25 12.22 3 195848 6364 34754716
Intestinal anastomosis 25.19 12.22 17 195834 261 34760819
Ostomy bag placement 25.14 12.22 6 195845 0 34761080
Fistula inflammation 25.14 12.22 6 195845 0 34761080
Burn infection 25.14 12.22 6 195845 0 34761080
Tachypnoea 25.07 12.22 40 195811 18312 34742768
Dental implantation 25.06 12.22 11 195840 66 34761014
Hodgkin's disease nodular sclerosis 25.03 12.22 7 195844 6 34761074
Hyperuricaemia 25.03 12.22 7 195844 8036 34753044
Feeling cold 25 12.22 122 195729 10517 34750563
Nocturia 24.95 12.22 13 195838 10197 34750883
Right ventricular failure 24.93 12.22 9 195842 8775 34752305
Dysuria 24.81 12.22 74 195777 27078 34734002
Colonoscopy abnormal 24.79 12.22 11 195840 68 34761012
Hypoacusis 24.75 12.22 33 195818 16268 34744812
Skin mass 24.68 12.22 63 195788 3922 34757158
Asthma 24.68 12.22 139 195712 42517 34718563
Muscle spasms 24.67 12.22 572 195279 74429 34686651
Antibody test positive 24.65 12.22 24 195827 634 34760446
Device dislocation 24.64 12.22 3 195848 6246 34754834
Bowel movement irregularity 24.62 12.22 53 195798 2952 34758128
Generalised oedema 24.61 12.22 20 195831 12388 34748692
Anal fissure haemorrhage 24.52 12.22 7 195844 7 34761073
Hypothermia 24.37 12.22 15 195836 10733 34750347
Elbow operation 24.37 12.22 13 195838 126 34760954
Blood triglycerides increased 24.33 12.22 26 195825 14133 34746947
Pneumocystis jirovecii infection 24.32 12.22 39 195812 1731 34759349
Toxic skin eruption 24.31 12.22 17 195834 11368 34749712
Ventricular extrasystoles 24.26 12.22 19 195832 11989 34749091
Needle issue 24.21 12.22 3 195848 6162 34754918
Immunosuppression 24.10 12.22 84 195767 6220 34754860
Thinking abnormal 24.07 12.22 3 195848 6134 34754946
Neurogenic shock 23.97 12.22 16 195835 241 34760839
Polyuria 23.97 12.22 9 195842 8565 34752515
Ageusia 23.92 12.22 14 195837 10294 34750786
Decubitus ulcer 23.90 12.22 10 195841 8911 34752169
Sudden death 23.87 12.22 30 195821 15171 34745909
Fear of injection 23.84 12.22 36 195815 1516 34759564
Amnesia 23.84 12.22 73 195778 26490 34734590
Electrocardiogram abnormal 23.77 12.22 11 195840 9236 34751844
Accidental exposure to product 23.73 12.22 22 195829 12780 34748300
Gastrointestinal stoma complication 23.71 12.22 33 195818 1289 34759791
Myasthenia gravis 23.63 12.22 5 195846 6935 34754145
Atypical mycobacterial infection 23.52 12.22 27 195824 866 34760214
Anastomotic ulcer 23.51 12.22 18 195833 340 34760740
Periumbilical abscess 23.49 12.22 10 195841 55 34761025
Enterocutaneous fistula 23.48 12.22 29 195822 1006 34760074
Gynaecomastia 23.38 12.22 14 195837 10166 34750914
Fear 23.23 12.22 15 195836 10461 34750619
Ear infection 23.10 12.22 116 195735 10115 34750965
Oral surgery 23.04 12.22 22 195829 567 34760513
Colon injury 22.86 12.22 9 195842 39 34761041
Obesity 22.86 12.22 23 195828 12855 34748225
Genital cancer male 22.73 12.22 6 195845 3 34761077
Cortical dysplasia 22.73 12.22 6 195845 3 34761077
Sleep apnoea syndrome 22.72 12.22 50 195801 20271 34740809
Renal neoplasm 22.71 12.22 32 195819 1265 34759815
Seminoma 22.70 12.22 15 195836 222 34760858
Taste disorder 22.69 12.22 6 195845 7149 34753931
Blood potassium decreased 22.67 12.22 41 195810 17874 34743206
Gastrointestinal stenosis 22.62 12.22 12 195839 115 34760965
Overgrowth bacterial 22.62 12.22 12 195839 115 34760965
Blister 22.59 12.22 60 195791 22798 34738282
Transurethral prostatectomy 22.56 12.22 18 195833 362 34760718
Post procedural infection 22.43 12.22 69 195782 4787 34756293
Drainage 22.41 12.22 7 195844 12 34761068
Tooth abscess 22.39 12.22 78 195773 5775 34755305
Skin injury 22.32 12.22 44 195807 2301 34758779
Gastrooesophageal reflux disease 22.26 12.22 123 195728 37801 34723279
Faecal calprotectin decreased 22.25 12.22 10 195841 64 34761016
Skin infection 22.11 12.22 94 195757 7643 34753437
Antiphospholipid syndrome 22.08 12.22 20 195831 481 34760599
Acute myeloid leukaemia 22.08 12.22 43 195808 18227 34742853
Oesophagitis 22.07 12.22 25 195826 13236 34747844
Pharyngeal paraesthesia 22.02 12.22 23 195828 662 34760418
Mycobacterial infection 21.94 12.22 44 195807 2330 34758750
Hernia 21.88 12.22 109 195742 9474 34751606
Cytomegalovirus enteritis 21.88 12.22 20 195831 487 34760593
SARS-CoV-2 test positive 21.78 12.22 78 195773 5855 34755225
Adrenal insufficiency 21.77 12.22 28 195823 14019 34747061
Gastrointestinal carcinoma 21.77 12.22 38 195813 1810 34759270
Mononeuropathy multiplex 21.67 12.22 14 195837 199 34760881
Atrioventricular block 21.66 12.22 9 195842 8054 34753026
Shock haemorrhagic 21.66 12.22 19 195832 11335 34749745
Apathy 21.63 12.22 6 195845 6926 34754154
Mycobacterium haemophilum infection 21.61 12.22 11 195840 96 34760984
Atrioventricular block first degree 21.56 12.22 4 195847 6088 34754992
Acute graft versus host disease 21.51 12.22 5 195846 6498 34754582
Headache 21.45 12.22 1350 194501 199285 34561795
Product use in unapproved indication 21.44 12.22 833 195018 116666 34644414
Abscess rupture 21.43 12.22 8 195843 29 34761051
Drain placement 21.38 12.22 10 195841 71 34761009
Hepatic cytolysis 21.35 12.22 30 195821 14466 34746614
Visual acuity reduced 21.31 12.22 36 195815 16113 34744967
Pericardial effusion 21.27 12.22 69 195782 24593 34736487
Gastrointestinal cancer metastatic 21.26 12.22 10 195841 72 34761008
Emotional distress 21.24 12.22 32 195819 14994 34746086
Scleral discolouration 21.23 12.22 15 195836 249 34760831
Schizophrenia 21.22 12.22 11 195840 8655 34752425
Hepatitis acute 21.21 12.22 8 195843 7593 34753487
Blood pressure decreased 21.20 12.22 406 195445 51109 34709971
Hepatitis cholestatic 21.14 12.22 9 195842 7938 34753142
Dialysis 21.09 12.22 19 195832 11189 34749891
Infusion site oedema 21.08 12.22 14 195837 209 34760871
Ecchymosis 21.02 12.22 6 195845 6797 34754283
Hodgkin's disease stage II 21.02 12.22 6 195845 6 34761074
Vision blurred 20.92 12.22 161 195690 45802 34715278
Prescribed underdose 20.92 12.22 12 195839 8921 34752159
Phototherapy 20.83 12.22 8 195843 32 34761048
Cystitis escherichia 20.79 12.22 13 195838 174 34760906
Proteinuria 20.73 12.22 46 195805 18596 34742484
Gastroenteritis salmonella 20.71 12.22 20 195831 523 34760557
Gastric ulcer haemorrhage 20.66 12.22 3 195848 5463 34755617
Haemolytic anaemia 20.65 12.22 17 195834 10462 34750618
Ocular hyperaemia 20.57 12.22 122 195729 11330 34749750
Gastric ulcer 20.55 12.22 35 195816 15615 34745465
Spleen tuberculosis 20.25 12.22 7 195844 19 34761061
Granuloma skin 20.12 12.22 30 195821 1249 34759831
Breast feeding 20.10 12.22 6 195845 8 34761072
Injection site pruritus 20.08 12.22 7 195844 6976 34754104
Lip neoplasm malignant stage unspecified 19.99 12.22 7 195844 20 34761060
Laryngeal cancer 19.98 12.22 23 195828 740 34760340
Tooth extraction 19.84 12.22 65 195786 4663 34756417
Ulcer 19.83 12.22 100 195751 8735 34752345
Graft versus host disease 19.78 12.22 18 195833 10551 34750529
Dry skin 19.74 12.22 99 195752 31188 34729892
Pain in extremity 19.70 12.22 882 194969 125631 34635449
Incorrect route of product administration 19.67 12.22 33 195818 14812 34746268
Malignant melanoma stage I 19.67 12.22 10 195841 87 34760993
Concomitant disease aggravated 19.63 12.22 4 195847 5697 34755383
Visual impairment 19.47 12.22 119 195732 35683 34725397
Heart rate abnormal 19.46 12.22 36 195815 1795 34759285
Brain natriuretic peptide increased 19.43 12.22 4 195847 5655 34755425
Sleep disorder due to a general medical condition 19.42 12.22 3 195848 5218 34755862
Gallbladder operation 19.36 12.22 19 195832 507 34760573
Myocardial ischaemia 19.32 12.22 43 195808 17365 34743715
Anal fistula infection 19.27 12.22 7 195844 23 34761057
Infective pulmonary exacerbation of cystic fibrosis 19.25 12.22 7 195844 6794 34754286
Bundle branch block right 19.23 12.22 9 195842 7507 34753573
Immune thrombocytopenia 19.11 12.22 14 195837 9138 34751942
Anaphylactoid reaction 19.04 12.22 41 195810 2284 34758796
Tinnitus 18.99 12.22 54 195797 20064 34741016
Obsessive-compulsive disorder 18.96 12.22 4 195847 5560 34755520
Ileocolectomy 18.95 12.22 6 195845 11 34761069
Left ventricular hypertrophy 18.92 12.22 11 195840 8119 34752961
Blood lactic acid increased 18.91 12.22 7 195844 6721 34754359
Red blood cell sedimentation rate 18.89 12.22 28 195823 1160 34759920
Myeloid leukaemia 18.87 12.22 17 195834 406 34760674
Duodenal ulcer 18.87 12.22 18 195833 10314 34750766
Enterocolonic fistula 18.83 12.22 10 195841 96 34760984
Hepatic steatosis 18.78 12.22 171 195680 18191 34742889
Sexual dysfunction 18.68 12.22 6 195845 6297 34754783
Acute pulmonary oedema 18.47 12.22 9 195842 7334 34753746
Catatonia 18.44 12.22 3 195848 5022 34756058
Endodontic procedure 18.36 12.22 17 195834 421 34760659
Hemiparesis 18.32 12.22 38 195813 15740 34745340
Pulmonary function test decreased 18.19 12.22 3 195848 4972 34756108
Lip and/or oral cavity cancer 18.15 12.22 16 195835 371 34760709
Liver function test abnormal 18.12 12.22 101 195750 30973 34730107
Device occlusion 18.08 12.22 7 195844 6538 34754542
Pulseless electrical activity 17.89 12.22 9 195842 7202 34753878
Hypotonia 17.75 12.22 11 195840 7842 34753238
Anti-saccharomyces cerevisiae antibody 17.71 12.22 6 195845 15 34761065
Pseudopolyposis 17.69 12.22 8 195843 52 34761028
Testis cancer 17.64 12.22 30 195821 1399 34759681
Gastrointestinal mucosa hyperaemia 17.57 12.22 14 195837 281 34760799
Staphylococcal bacteraemia 17.55 12.22 13 195838 8439 34752641
Incorrect dosage administered 17.54 12.22 28 195823 1238 34759842
Discharge 17.52 12.22 15 195836 334 34760746
Anorectal swelling 17.51 12.22 5 195846 5 34761075
Lewis-Sumner syndrome 17.49 12.22 7 195844 32 34761048
Laryngeal neoplasm 17.49 12.22 7 195844 32 34761048
Cardiomyopathy 17.47 12.22 43 195808 16765 34744315
Prerenal failure 17.35 12.22 37 195814 2047 34759033
Protein urine present 17.33 12.22 4 195847 5224 34755856
Atrioventricular block complete 17.29 12.22 16 195835 9303 34751777
Oesophageal adenocarcinoma 17.25 12.22 23 195828 862 34760218
Serum ferritin decreased 17.24 12.22 21 195830 718 34760362
Chlamydial infection 17.23 12.22 13 195838 240 34760840
Tuberculosis of central nervous system 17.20 12.22 12 195839 195 34760885
Polyneuropathy 17.19 12.22 36 195815 14860 34746220
Accident at work 17.18 12.22 22 195829 792 34760288
Partial seizures 17.12 12.22 3 195848 4757 34756323
Osteoarthritis 17.11 12.22 184 195667 20458 34740622
Blood glucose abnormal 17.06 12.22 6 195845 5946 34755134
Cutaneous nocardiosis 17.05 12.22 11 195840 156 34760924
Neoplasm skin 17.03 12.22 22 195829 799 34760281
Groin abscess 17.02 12.22 20 195831 658 34760422
Abnormal faeces 17.02 12.22 49 195802 3276 34757804
Gastritis erosive 16.97 12.22 6 195845 5926 34755154
Pharyngeal neoplasm 16.92 12.22 6 195845 18 34761062
Paradoxical psoriasis 16.92 12.22 6 195845 18 34761062
Coordination abnormal 16.88 12.22 11 195840 7633 34753447
Opportunistic infection 16.87 12.22 32 195819 1626 34759454
Hordeolum 16.84 12.22 25 195826 1037 34760043
Infusion site swelling 16.79 12.22 41 195810 2483 34758597
Foreign body in eye 16.78 12.22 10 195841 122 34760958
Anal neoplasm 16.76 12.22 4 195847 0 34761080
Benign renal neoplasm 16.76 12.22 4 195847 0 34761080
Anal dilation procedure 16.76 12.22 4 195847 0 34761080
Small intestine carcinoma metastatic 16.76 12.22 4 195847 0 34761080
Granuloma 16.73 12.22 48 195803 3203 34757877
Drug-induced liver injury 16.65 12.22 94 195757 28738 34732342
Epstein Barr virus positive mucocutaneous ulcer 16.52 12.22 15 195836 362 34760718
Anorectal discomfort 16.51 12.22 35 195816 1929 34759151
Postoperative wound infection 16.49 12.22 62 195789 4764 34756316
Mycobacterium tuberculosis complex test positive 16.49 12.22 28 195823 1304 34759776
Urosepsis 16.46 12.22 29 195822 12770 34748310
Tympanic membrane perforation 16.45 12.22 14 195837 309 34760771
Post transplant lymphoproliferative disorder 16.42 12.22 8 195843 6520 34754560
Cerebral haematoma 16.40 12.22 3 195848 4612 34756468
Influenza 16.39 12.22 379 195472 49287 34711793
Skin plaque 16.37 12.22 60 195791 4554 34756526
Dizziness postural 16.36 12.22 7 195844 6157 34754923
Arteriosclerosis coronary artery 16.32 12.22 28 195823 12457 34748623
Embolism 16.31 12.22 12 195839 7817 34753263
Intestinal adenocarcinoma 16.30 12.22 8 195843 64 34761016
Superficial spreading melanoma stage unspecified 16.24 12.22 11 195840 170 34760910
Basosquamous carcinoma 16.14 12.22 9 195842 96 34760984
Leishmaniasis 16.12 12.22 14 195837 318 34760762
Epstein-Barr virus infection reactivation 16.10 12.22 25 195826 1079 34760001
Dyspepsia 16.10 12.22 130 195721 36602 34724478
Hyperhidrosis 16.09 12.22 546 195305 75146 34685934
Lymphadenitis bacterial 16.08 12.22 7 195844 41 34761039
Multifocal motor neuropathy 16.08 12.22 7 195844 41 34761039
Circumcision 16.02 12.22 6 195845 22 34761058
Hypoxic-ischaemic encephalopathy 15.99 12.22 3 195848 4529 34756551
Oesophageal fibrosis 15.97 12.22 11 195840 175 34760905
Hypogammaglobulinaemia 15.95 12.22 12 195839 7728 34753352
Terminal ileitis 15.93 12.22 12 195839 221 34760859
Device malfunction 15.92 12.22 21 195830 10400 34750680
Deafness 15.91 12.22 24 195827 11241 34749839
Mood altered 15.88 12.22 16 195835 8936 34752144
Sleep disorder 15.87 12.22 108 195743 31580 34729500
Eye inflammation 15.80 12.22 37 195814 2181 34758899
Arthrodesis 15.73 12.22 16 195835 446 34760634
Anal ulcer 15.72 12.22 22 195829 864 34760216
Hydronephrosis 15.65 12.22 21 195830 10325 34750755
Eyelid infection 15.62 12.22 6 195845 24 34761056
Nasopharyngeal cancer 15.61 12.22 10 195841 140 34760940
Ear neoplasm 15.60 12.22 8 195843 71 34761009
Disseminated intravascular coagulation 15.56 12.22 66 195785 21750 34739330
Toxic encephalopathy 15.55 12.22 5 195846 5244 34755836
Hyperphosphataemia 15.52 12.22 3 195848 4434 34756646
Histone antibody positive 15.51 12.22 5 195846 10 34761070
Electrocardiogram ST segment elevation 15.50 12.22 5 195846 5233 34755847
Pulmonary haemorrhage 15.50 12.22 21 195830 10283 34750797
Thyroiditis subacute 15.42 12.22 7 195844 46 34761034
Lipase increased 15.40 12.22 18 195833 9398 34751682
Stress at work 15.39 12.22 12 195839 233 34760847
Abdominal operation 15.38 12.22 9 195842 106 34760974
Blood pressure diastolic abnormal 15.36 12.22 4 195847 4814 34756266
Rheumatoid factor 15.32 12.22 8 195843 74 34761006
Pathological fracture 15.29 12.22 3 195848 4388 34756692
Upper limb fracture 15.28 12.22 60 195791 4706 34756374
Blood glucose decreased 15.27 12.22 32 195819 13205 34747875
Ventricular hypokinesia 15.23 12.22 6 195845 5546 34755534
Dementia 15.23 12.22 34 195817 13714 34747366
Cyanosis 15.22 12.22 123 195728 12641 34748439
Perineal fistula 15.20 12.22 5 195846 11 34761069
Product complaint 15.15 12.22 7 195844 5883 34755197
Oral pustule 15.13 12.22 12 195839 239 34760841
Peripheral arterial occlusive disease 15.08 12.22 7 195844 5867 34755213
Breath sounds abnormal 15.06 12.22 10 195841 6871 34754209
Adverse event 15.06 12.22 167 195684 18710 34742370
Skin exfoliation 15.01 12.22 91 195760 27341 34733739
Protein total decreased 15.00 12.22 5 195846 5125 34755955
Wound 14.99 12.22 138 195713 14726 34746354
Dermatitis acneiform 14.94 12.22 8 195843 6181 34754899
Precancerous cells present 14.82 12.22 7 195844 51 34761029
Streptococcal infection 14.75 12.22 61 195790 4900 34756180
Liver injury 14.74 12.22 39 195812 14839 34746241
Colitis ischaemic 14.73 12.22 9 195842 6466 34754614
Blood albumin decreased 14.68 12.22 34 195817 13538 34747542
Rheumatoid nodule 14.67 12.22 43 195808 2904 34758176
Road traffic accident 14.67 12.22 156 195695 17294 34743786
Squamous cell carcinoma of lung 14.65 12.22 33 195818 1896 34759184
Respiratory acidosis 14.63 12.22 5 195846 5045 34756035
Salmonella sepsis 14.63 12.22 10 195841 157 34760923
Hypercapnia 14.62 12.22 3 195848 4252 34756828
Omphalitis 14.62 12.22 5 195846 13 34761067
Postoperative abscess 14.62 12.22 13 195838 305 34760775
Radial nerve palsy 14.62 12.22 8 195843 82 34760998
Arteriosclerosis 14.61 12.22 28 195823 11940 34749140
Neuroendocrine carcinoma of the skin 14.57 12.22 20 195831 771 34760309
Staphylococcus test 14.54 12.22 4 195847 3 34761077
Gliomatosis cerebri 14.54 12.22 4 195847 3 34761077
Malignant respiratory tract neoplasm 14.54 12.22 4 195847 3 34761077
Carotid artery stenosis 14.49 12.22 5 195846 5014 34756066
Drug level increased 14.47 12.22 69 195782 22027 34739053
Respiratory tract infection 14.46 12.22 59 195792 19653 34741427
Hypoalbuminaemia 14.41 12.22 29 195822 12145 34748935
Tonsillitis bacterial 14.40 12.22 6 195845 31 34761049
Therapeutic product effect delayed 14.40 12.22 26 195825 1272 34759808
Ventricular hypertrophy 14.35 12.22 4 195847 4603 34756477
Double stranded DNA antibody positive 14.35 12.22 11 195840 208 34760872
Hepatitis fulminant 14.30 12.22 3 195848 4187 34756893
Mouth haemorrhage 14.19 12.22 6 195845 5313 34755767
Low birth weight baby 14.17 12.22 14 195837 7891 34753189
Apnoea 14.16 12.22 10 195841 6654 34754426
Tubulointerstitial nephritis 14.15 12.22 65 195786 20959 34740121
Eye laser surgery 14.10 12.22 5 195846 15 34761065
Performance status decreased 14.05 12.22 3 195848 4134 34756946
Keratomileusis 14.01 12.22 4 195847 4 34761076
Amylase increased 14.00 12.22 8 195843 5960 34755120
Behaviour disorder 13.99 12.22 5 195846 4905 34756175
Neuralgia 13.94 12.22 41 195810 15072 34746008
Intestinal tuberculosis 13.92 12.22 9 195842 128 34760952
Diplopia 13.92 12.22 48 195803 16795 34744285
Throat cancer 13.89 12.22 25 195826 1220 34759860
Obstruction 13.85 12.22 40 195811 2679 34758401
Coronary artery aneurysm 13.83 12.22 8 195843 92 34760988
Hepatocellular carcinoma 13.81 12.22 13 195838 7496 34753584
Demyelinating polyneuropathy 13.80 12.22 25 195826 1226 34759854
Dyslipidaemia 13.72 12.22 13 195838 7475 34753605
Pemphigoid 13.72 12.22 17 195834 8649 34752431
Bronchiectasis 13.68 12.22 98 195753 9703 34751377
Cholangiocarcinoma 13.68 12.22 26 195825 1323 34759757
Bile duct cancer 13.66 12.22 18 195833 667 34760413
Muscle spasticity 13.66 12.22 8 195843 5880 34755200
Visceral leishmaniasis 13.65 12.22 17 195834 595 34760485
Ear discomfort 13.59 12.22 39 195812 2603 34758477
Blindness 13.58 12.22 41 195810 14945 34746135
Supraventricular tachycardia 13.57 12.22 26 195825 11091 34749989
Narcotic bowel syndrome 13.57 12.22 9 195842 134 34760946
Pancreatitis acute 13.56 12.22 97 195754 28044 34733036
Alopecia areata 13.55 12.22 11 195840 227 34760853
Hypercalcaemia 13.53 12.22 43 195808 15425 34745655
Bladder cancer 13.44 12.22 145 195706 16133 34744947
Colon cancer metastatic 13.44 12.22 29 195822 1618 34759462
Prostatic specific antigen increased 13.42 12.22 40 195811 14640 34746440
Amyotrophic lateral sclerosis 13.40 12.22 22 195829 996 34760084
Scleral hyperaemia 13.38 12.22 7 195844 65 34761015
SAPHO syndrome 13.37 12.22 12 195839 285 34760795
Petechiae 13.37 12.22 20 195831 9398 34751682
Rectal fissure 13.33 12.22 13 195838 344 34760736
Alopecia 13.32 12.22 201 195650 24154 34736926
Bone pain 13.31 12.22 65 195786 20621 34740459
Infection 13.31 12.22 630 195221 90285 34670795
Disseminated aspergillosis 13.29 12.22 19 195832 761 34760319
Vaccination complication 13.29 12.22 7 195844 66 34761014
Rheumatoid lung 13.28 12.22 21 195830 921 34760159
Lung cancer metastatic 13.24 12.22 40 195811 2747 34758333
Peritonitis bacterial 13.21 12.22 9 195842 6101 34754979
Blood parathyroid hormone decreased 13.17 12.22 27 195824 1453 34759627
Tendon operation 13.14 12.22 6 195845 40 34761040
Anti-platelet antibody 13.13 12.22 4 195847 6 34761074
Small intestine operation 13.13 12.22 4 195847 6 34761074
Scleritis 13.11 12.22 16 195835 548 34760532
Therapy partial responder 13.09 12.22 21 195830 9595 34751485
Wound infection 13.09 12.22 76 195775 7003 34754077
Gastrointestinal viral infection 13.07 12.22 11 195840 239 34760841
Ischaemic cardiomyopathy 13.05 12.22 10 195841 6379 34754701
Gastrointestinal dysplasia 13.02 12.22 5 195846 20 34761060
Wrist deformity 12.97 12.22 13 195838 356 34760724
Glioma 12.97 12.22 13 195838 356 34760724
Rash 12.97 12.22 1073 194778 221679 34539401
Bowen's disease 12.91 12.22 9 195842 146 34760934
Faecaloma 12.91 12.22 7 195844 5370 34755710
Rhinovirus infection 12.91 12.22 4 195847 4295 34756785
Tonsil cancer 12.89 12.22 23 195828 1115 34759965
Systemic lupus erythematosus rash 12.85 12.22 7 195844 71 34761009
Hepatitis B reactivation 12.85 12.22 3 195848 3888 34757192
Panniculitis 12.85 12.22 32 195819 1962 34759118
Duodenal ulcer haemorrhage 12.83 12.22 6 195845 5007 34756073
Exposure to communicable disease 12.81 12.22 9 195842 148 34760932
Cerebral ischaemia 12.78 12.22 10 195841 6312 34754768
Renal tubular disorder 12.77 12.22 5 195846 4638 34756442
Small cell lung cancer extensive stage 12.75 12.22 4 195847 7 34761073
Staphylococcal skin infection 12.70 12.22 20 195831 874 34760206
Gastrointestinal tract irritation 12.67 12.22 12 195839 306 34760774
Intestinal ischaemia 12.64 12.22 15 195836 7779 34753301
Azotaemia 12.62 12.22 6 195845 4961 34756119
Polyomavirus-associated nephropathy 12.62 12.22 3 195848 3841 34757239
Rectal discharge 12.62 12.22 11 195840 251 34760829
Pharyngitis 12.62 12.22 82 195769 7862 34753218
Stoma site rash 12.57 12.22 3 195848 0 34761080
Lupus pleurisy 12.57 12.22 3 195848 0 34761080
Dientamoeba infection 12.57 12.22 3 195848 0 34761080
Epithelioid sarcoma 12.57 12.22 3 195848 0 34761080
Aneurysmal bone cyst 12.57 12.22 3 195848 0 34761080
Nephroblastoma 12.57 12.22 3 195848 0 34761080
Intestinal transit time increased 12.57 12.22 3 195848 0 34761080
Hodgkin's disease stage IV 12.57 12.22 3 195848 0 34761080
Arthritis salmonella 12.57 12.22 3 195848 0 34761080
Anal fistula repair 12.57 12.22 3 195848 0 34761080
Laryngitis viral 12.57 12.22 3 195848 0 34761080
Jejunectomy 12.57 12.22 3 195848 0 34761080
Malignant palate neoplasm 12.57 12.22 3 195848 0 34761080
Biopsy skin 12.57 12.22 3 195848 0 34761080
Malignant melanoma of sites other than skin 12.57 12.22 3 195848 0 34761080
Exploratory operation 12.57 12.22 3 195848 0 34761080
Extrasystoles 12.52 12.22 3 195848 3820 34757260
International normalised ratio decreased 12.43 12.22 5 195846 4562 34756518
Meningitis herpes 12.41 12.22 4 195847 8 34761072
Cyclic neutropenia 12.41 12.22 4 195847 8 34761072
Nephritis bacterial 12.41 12.22 4 195847 8 34761072
Pulmonary sarcoidosis 12.41 12.22 16 195835 580 34760500
Drug clearance increased 12.36 12.22 8 195843 114 34760966
Bloody discharge 12.36 12.22 15 195836 511 34760569
Symptom recurrence 12.33 12.22 18 195833 735 34760345
Septic pulmonary embolism 12.33 12.22 6 195845 47 34761033
Immune reconstitution inflammatory syndrome associated tuberculosis 12.32 12.22 14 195837 444 34760636
Fluctuance 12.30 12.22 5 195846 24 34761056
Carcinoma in situ of skin 12.29 12.22 7 195844 78 34761002
Acute respiratory distress syndrome 12.27 12.22 90 195761 25879 34735201
Discomfort 12.25 12.22 161 195690 18777 34742303
Inadequate diet 12.24 12.22 8 195843 116 34760964
Atrial septal defect 12.23 12.22 14 195837 7378 34753702
Tuberculosis liver 12.23 12.22 6 195845 48 34761032

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 10470.80 11.54 20331 514635 886884 78322538
Intentional product use issue 8445.74 11.54 7463 527503 144649 79064773
Infusion related reaction 6024.94 11.54 7560 527406 222677 78986745
Inappropriate schedule of product administration 6023.84 11.54 5840 529126 127788 79081634
Product use issue 5517.28 11.54 6908 528058 202914 79006508
Condition aggravated 5165.39 11.54 10755 524211 490369 78719053
Drug ineffective 2786.71 11.54 14411 520555 1066502 78142920
Toxicity to various agents 2441.59 11.54 88 534878 421452 78787970
Blood pressure fluctuation 2417.94 11.54 2603 532363 64542 79144880
Acute kidney injury 2260.36 11.54 385 534581 519019 78690403
Drug interaction 1938.63 11.54 250 534716 414933 78794489
Death 1932.04 11.54 696 534270 565818 78643604
Treatment failure 1865.07 11.54 3760 531206 166726 79042696
Drug level below therapeutic 1816.00 11.54 1009 533957 8761 79200661
Drug intolerance 1752.10 11.54 4788 530178 259331 78950091
Synovitis 1701.93 11.54 3369 531597 147365 79062057
Arthralgia 1684.50 11.54 7935 527031 563868 78645554
Contraindicated product administered 1621.97 11.54 3389 531577 154149 79055273
Completed suicide 1447.71 11.54 44 534922 245723 78963699
Therapeutic product effect decreased 1430.31 11.54 3299 531667 160564 79048858
Weight increased 1424.64 11.54 4593 530373 272793 78936629
Lupus-like syndrome 1414.91 11.54 977 533989 12880 79196542
Haematochezia 1397.92 11.54 2278 532688 85367 79124055
Frequent bowel movements 1391.96 11.54 1325 533641 28214 79181208
Intestinal resection 1384.82 11.54 618 534348 3139 79206283
Drug specific antibody present 1316.22 11.54 716 534250 5936 79203486
Therapeutic response shortened 1269.70 11.54 965 534001 14898 79194524
Systemic lupus erythematosus 1261.41 11.54 2619 532347 118530 79090892
Febrile neutropenia 1252.61 11.54 74 534892 230925 78978497
Joint swelling 1229.58 11.54 4491 530475 284155 78925267
Fistula 1206.44 11.54 863 534103 12077 79197345
Arthropathy 1203.39 11.54 3241 531725 173870 79035552
Anaemia 1152.31 11.54 788 534178 444227 78765195
Neutropenia 1147.50 11.54 262 534704 287448 78921974
Drug level decreased 1145.82 11.54 873 534093 13529 79195893
Faecal calprotectin increased 1075.79 11.54 589 534377 4952 79204470
Drug abuse 1030.94 11.54 11 534955 162680 79046742
Pemphigus 944.35 11.54 2073 532893 97509 79111913
Alopecia 935.50 11.54 3541 531425 227814 78981608
Hand deformity 924.63 11.54 2109 532857 101810 79107612
Anal fissure 923.12 11.54 600 534366 7103 79202319
Fall 899.36 11.54 1173 533793 486456 78722966
Hyponatraemia 892.69 11.54 82 534884 177766 79031656
Heart rate decreased 882.81 11.54 1645 533321 68671 79140751
Skin cancer 867.84 11.54 756 534210 14284 79195138
Anti-cyclic citrullinated peptide antibody positive 842.41 11.54 1778 533188 81365 79128057
Tuberculosis 823.15 11.54 737 534229 14461 79194961
Disseminated tuberculosis 818.59 11.54 447 534519 3736 79205686
Incorrect dose administered 817.67 11.54 1674 533292 74956 79134466
Thrombocytopenia 803.88 11.54 387 534579 264872 78944550
Hypotension 801.68 11.54 1069 533897 439248 78770174
Glossodynia 789.61 11.54 1977 532989 101360 79108062
Hypersensitivity 784.62 11.54 3661 531305 258578 78950844
Cardiac arrest 775.27 11.54 115 534851 171981 79037441
Pulmonary tuberculosis 761.93 11.54 537 534429 7328 79202094
Pericarditis 743.37 11.54 1943 533023 102293 79107129
Disease progression 730.50 11.54 170 534796 184192 79025230
Poor venous access 708.55 11.54 735 534231 17414 79192008
Platelet count decreased 702.35 11.54 216 534750 194448 79014974
Malignant neoplasm progression 692.41 11.54 59 534907 135931 79073491
Hyperkalaemia 664.29 11.54 23 534943 114375 79095047
Rheumatoid factor positive 664.25 11.54 1329 533637 58510 79150912
Wound 639.32 11.54 1972 532994 114207 79095215
Anal fistula 633.27 11.54 457 534509 6487 79202935
Atrial fibrillation 626.96 11.54 271 534695 197615 79011807
Uveitis 618.55 11.54 660 534306 16170 79193252
Intentional overdose 605.95 11.54 24 534942 105936 79103486
White blood cell count decreased 601.06 11.54 255 534711 188033 79021389
Anal abscess 592.31 11.54 496 534470 8859 79200563
Pancytopenia 590.55 11.54 188 534778 165557 79043865
Overdose 587.17 11.54 250 534716 183956 79025466
C-reactive protein abnormal 585.19 11.54 1114 533852 47253 79162169
Somnolence 584.00 11.54 449 534517 238532 78970890
Colectomy 582.36 11.54 332 534634 3042 79206380
Heart rate irregular 580.85 11.54 893 534073 31786 79177636
Abscess 563.50 11.54 732 534234 22219 79187203
Cardiac failure congestive 560.70 11.54 133 534833 142269 79067153
Drug level above therapeutic 555.41 11.54 464 534502 8259 79201163
Therapeutic product effect incomplete 553.01 11.54 2145 532821 139500 79069922
Psoriasis 546.21 11.54 1577 533389 88010 79121412
Abdominal discomfort 542.94 11.54 3201 531765 247526 78961896
Electrocardiogram QT prolonged 536.19 11.54 15 534951 90371 79119051
Cardio-respiratory arrest 533.90 11.54 54 534912 108456 79100966
Red blood cell sedimentation rate increased 533.57 11.54 1040 533926 44902 79164520
Cardiac failure 531.79 11.54 187 534779 154655 79054767
Seizure 526.94 11.54 306 534660 188528 79020894
Rhabdomyolysis 524.28 11.54 45 534921 103086 79106336
Hypoglycaemia 520.11 11.54 43 534923 101551 79107871
Discomfort 517.29 11.54 1935 533031 123682 79085740
Rheumatoid arthritis 506.35 11.54 2745 532221 205725 79003697
Swelling 503.95 11.54 2820 532146 213891 78995531
Gastrointestinal haemorrhage 499.46 11.54 183 534783 147536 79061886
Acne 497.34 11.54 753 534213 26437 79182985
Blood creatinine increased 482.17 11.54 218 534748 154839 79054583
Transplant dysfunction 474.09 11.54 391 534575 6830 79202592
Musculoskeletal stiffness 468.75 11.54 2368 532598 172640 79036782
Coma 465.51 11.54 62 534904 100587 79108835
Helicobacter infection 460.13 11.54 1263 533703 68441 79140981
Hypokalaemia 459.76 11.54 195 534771 143845 79065577
Loss of personal independence in daily activities 454.24 11.54 1618 533348 100962 79108460
Hepatic enzyme increased 451.85 11.54 2417 532549 180193 79029229
Neutrophil count decreased 448.90 11.54 52 534914 93907 79115515
Duodenal ulcer perforation 448.33 11.54 1211 533755 65000 79144422
Bradycardia 443.21 11.54 177 534789 135380 79074042
Hallucination 436.97 11.54 37 534929 85708 79123714
Basal cell carcinoma 436.35 11.54 848 534118 36527 79172895
Neuropathy peripheral 432.62 11.54 203 534763 141102 79068320
Inflammation 429.95 11.54 1496 533470 92257 79117165
COVID-19 428.23 11.54 2142 532824 155532 79053890
International normalised ratio increased 427.82 11.54 38 534928 84683 79124739
Metabolic acidosis 419.51 11.54 36 534930 82493 79126929
Depressed level of consciousness 418.46 11.54 72 534894 96580 79112842
Blood pressure increased 412.86 11.54 2628 532338 208732 79000690
Ovarian cyst 412.52 11.54 466 534500 12189 79197233
Intestinal stenosis 410.04 11.54 276 534690 3478 79205944
Renal failure 404.08 11.54 451 534515 200517 79008905
Arthritis 401.43 11.54 1681 533285 113199 79096223
Weight decreased 399.55 11.54 3886 531080 351312 78858110
Respiratory failure 398.88 11.54 375 534591 180536 79028886
Oedema peripheral 397.04 11.54 676 534290 251612 78957810
Body temperature fluctuation 397.04 11.54 272 534694 3535 79205887
Pyoderma gangrenosum 396.05 11.54 281 534685 3877 79205545
Clostridium difficile infection 393.53 11.54 879 534087 41806 79167616
Sleep disorder due to general medical condition, insomnia type 392.70 11.54 889 534077 42667 79166755
Flushing 388.84 11.54 1390 533576 86878 79122544
Dehydration 386.92 11.54 669 534297 247518 78961904
Asthenia 384.84 11.54 1945 533021 509744 78699678
Constipation 378.07 11.54 836 534130 282214 78927208
Hyperglycaemia 373.59 11.54 25 534941 70310 79139112
Red blood cell sedimentation rate abnormal 367.12 11.54 569 534397 20394 79189028
C-reactive protein increased 365.36 11.54 1774 533192 127253 79082169
Mucous stools 365.25 11.54 292 534674 4870 79204552
Lactic acidosis 365.09 11.54 28 534938 70331 79139091
Renal impairment 364.65 11.54 313 534653 157470 79051952
Maternal exposure during pregnancy 358.84 11.54 1838 533128 134700 79074722
Blood glucose increased 347.60 11.54 168 534798 114807 79094615
Injection site pain 335.14 11.54 230 534736 129608 79079814
Psoriatic arthropathy 331.41 11.54 1214 533752 76785 79132637
Hypoxia 327.46 11.54 141 534825 103102 79106320
Drug specific antibody 325.47 11.54 209 534757 2419 79207003
Balance disorder 323.25 11.54 129 534837 98728 79110694
Drug reaction with eosinophilia and systemic symptoms 321.19 11.54 30 534936 64214 79145208
Agitation 319.75 11.54 134 534832 99581 79109841
Sedation 313.90 11.54 7 534959 51888 79157534
Histoplasmosis disseminated 313.55 11.54 196 534770 2157 79207265
Mental status changes 310.20 11.54 41 534925 66918 79142504
Suicide attempt 304.44 11.54 89 534877 82843 79126579
Mucosal inflammation 300.59 11.54 69 534897 75511 79133911
Pain 298.85 11.54 6489 528477 697313 78512109
Acute myocardial infarction 297.22 11.54 75 534891 76961 79132461
Bone erosion 296.69 11.54 473 534493 17374 79192048
Abdominal pain 295.84 11.54 3948 531018 385621 78823801
Respiratory arrest 295.53 11.54 24 534942 57526 79151896
Drug hypersensitivity 295.19 11.54 3185 531781 295731 78913691
Folliculitis 293.33 11.54 928 534038 54452 79154970
Disorientation 289.47 11.54 39 534927 62737 79146685
Intentional product misuse 287.74 11.54 139 534827 95026 79114396
Encephalopathy 285.67 11.54 53 534913 67344 79142078
Multiple sclerosis relapse 282.54 11.54 6 534960 46527 79162895
Cognitive disorder 281.79 11.54 62 534904 69864 79139558
Pulmonary oedema 280.73 11.54 120 534846 88134 79121288
Confusional state 276.72 11.54 1145 533821 316852 78892570
Exposure during pregnancy 269.57 11.54 1367 533599 99765 79109657
Cerebrovascular accident 268.00 11.54 391 534575 154901 79054521
Irritable bowel syndrome 267.99 11.54 973 533993 61268 79148154
Erythema nodosum 264.75 11.54 246 534720 5071 79204351
Pneumonia aspiration 264.60 11.54 62 534904 66905 79142517
Herpes zoster 262.85 11.54 1279 533687 91804 79117618
Exposure to SARS-CoV-2 261.69 11.54 166 534800 1878 79207544
Injection site erythema 259.01 11.54 100 534866 78097 79131325
Neoplasm progression 258.72 11.54 24 534942 51658 79157764
Multiple organ dysfunction syndrome 257.13 11.54 256 534710 119990 79089432
Orthostatic hypotension 256.35 11.54 36 534930 56128 79153294
Haemoglobin decreased 255.81 11.54 708 534258 221411 78988011
Defaecation urgency 255.00 11.54 251 534715 5573 79203849
Dysarthria 254.84 11.54 69 534897 67553 79141869
Blood bilirubin increased 254.51 11.54 65 534901 66167 79143255
Hypomagnesaemia 251.12 11.54 16 534950 46895 79162527
Ascites 248.02 11.54 98 534868 75464 79133958
Coronary artery disease 246.38 11.54 67 534899 65407 79144015
Muscle injury 245.61 11.54 801 534165 47760 79161662
Aphthous ulcer 244.99 11.54 421 534545 16468 79192954
Ileal stenosis 242.23 11.54 168 534798 2230 79207192
Product dose omission issue 240.64 11.54 852 534114 246685 78962737
Hypervolaemia 236.39 11.54 12 534954 42678 79166744
Leukopenia 235.70 11.54 260 534706 116253 79093169
Dyspnoea exertional 234.49 11.54 147 534819 86926 79122496
Lymph node tuberculosis 234.11 11.54 121 534845 893 79208529
Blood creatine phosphokinase increased 233.45 11.54 76 534890 66014 79143408
Unresponsive to stimuli 231.93 11.54 46 534920 55742 79153680
Pulmonary hypertension 231.16 11.54 26 534940 48054 79161368
Myocardial infarction 231.07 11.54 562 534404 183567 79025855
Dysphagia 230.50 11.54 288 534678 121848 79087574
Decreased appetite 226.12 11.54 1358 533608 341060 78868362
Therapeutic response decreased 224.71 11.54 967 533999 65886 79143536
Blood urea increased 223.33 11.54 31 534935 48759 79160663
Infection 223.16 11.54 2542 532424 239170 78970252
Wrong technique in product usage process 221.66 11.54 109 534857 73766 79135656
Dizziness 221.21 11.54 2361 532605 524080 78685342
Urinary retention 220.65 11.54 54 534912 56576 79152846
Altered state of consciousness 220.30 11.54 20 534946 43802 79165620
Chronic obstructive pulmonary disease 216.84 11.54 154 534812 85265 79124157
Urticaria 215.13 11.54 2041 532925 183160 79026262
Sepsis 214.96 11.54 1002 533964 268426 78940996
Cytokine release syndrome 213.37 11.54 6 534960 35992 79173430
Cerebral haemorrhage 213.31 11.54 61 534905 57612 79151810
Plasma cell myeloma 213.03 11.54 48 534918 53211 79156211
Breast cancer 211.92 11.54 601 534365 33180 79176242
Aggression 211.88 11.54 42 534924 50916 79158506
Weight fluctuation 211.60 11.54 322 534644 11353 79198069
Ileostomy 211.06 11.54 136 534830 1584 79207838
Pneumonia 210.98 11.54 3139 531827 657107 78552315
Toxic epidermal necrolysis 209.64 11.54 26 534940 44555 79164867
Diarrhoea 206.65 11.54 4422 530544 876067 78333355
Rheumatic fever 206.51 11.54 535 534431 27990 79181432
Lymphoma 206.02 11.54 398 534568 17062 79192360
Knee arthroplasty 204.18 11.54 697 534269 42551 79166871
Pneumonia legionella 203.99 11.54 164 534802 2758 79206664
Agranulocytosis 202.87 11.54 30 534936 45000 79164422
Syncope 202.86 11.54 577 534389 178872 79030550
Large intestinal stenosis 200.88 11.54 161 534805 2695 79206727
Melaena 199.79 11.54 79 534887 60811 79148611
Palmar-plantar erythrodysaesthesia syndrome 198.35 11.54 5 534961 33129 79176293
Drug tolerance decreased 198.17 11.54 331 534635 12647 79196775
Granuloma skin 196.77 11.54 274 534692 8900 79200522
Histoplasmosis 196.15 11.54 147 534819 2218 79207204
Ventricular tachycardia 195.87 11.54 25 534941 41910 79167512
Vomiting 194.03 11.54 3221 531745 662607 78546815
Cardiogenic shock 193.34 11.54 26 534940 41888 79167534
Upper gastrointestinal haemorrhage 192.48 11.54 25 534941 41355 79168067
Delirium 191.67 11.54 171 534795 84456 79124966
Blood parathyroid hormone decreased 191.53 11.54 291 534675 10245 79199177
Colitis ulcerative 188.40 11.54 587 534379 34155 79175267
Pleural effusion 188.10 11.54 436 534530 144826 79064596
Infusion site extravasation 187.76 11.54 282 534684 9826 79199596
Panniculitis 186.87 11.54 314 534652 12057 79197365
Hepatosplenic T-cell lymphoma 186.26 11.54 99 534867 779 79208643
Acute respiratory failure 186.12 11.54 83 534883 59458 79149964
Transplant rejection 185.60 11.54 406 534560 19031 79190391
Hip arthroplasty 184.62 11.54 594 534372 35162 79174260
Full blood count abnormal 184.58 11.54 26 534940 40448 79168974
Disability 182.47 11.54 374 534592 16746 79192676
Haematoma 180.89 11.54 62 534904 52133 79157289
Enthesopathy 179.84 11.54 298 534668 11310 79198112
Dyskinesia 179.78 11.54 40 534926 44733 79164689
Intestinal obstruction 178.84 11.54 665 534301 42355 79167067
Pulmonary embolism 177.52 11.54 575 534391 171079 79038343
Haematuria 177.50 11.54 122 534844 68714 79140708
Neurotoxicity 177.36 11.54 10 534956 32508 79176914
Haemoptysis 176.72 11.54 77 534889 55922 79153500
Bone marrow failure 176.61 11.54 61 534905 51046 79158376
Impaired healing 175.94 11.54 1098 533868 86557 79122865
Hepatic failure 173.76 11.54 97 534869 61115 79148307
Mycobacterium marinum infection 172.37 11.54 77 534889 392 79209030
Mobility decreased 172.17 11.54 1405 533561 120770 79088652
Gastrointestinal disorder 171.49 11.54 1404 533562 120801 79088621
Hypophagia 171.49 11.54 46 534920 45321 79164101
Drug withdrawal syndrome 171.45 11.54 17 534949 34701 79174721
Peritoneal tuberculosis 171.41 11.54 79 534887 438 79208984
Intentional self-injury 170.76 11.54 12 534954 32407 79177015
Body temperature decreased 170.51 11.54 539 534427 31606 79177816
Nasopharyngitis 169.48 11.54 2516 532450 251365 78958057
Fistula discharge 167.45 11.54 108 534858 1260 79208162
Urinary tract infection 167.09 11.54 1116 533850 273396 78936026
Memory impairment 166.93 11.54 309 534657 111425 79097997
Dyspnoea 166.68 11.54 4428 530538 852597 78356825
Sinusitis bacterial 166.13 11.54 119 534847 1668 79207754
Diabetic ketoacidosis 165.18 11.54 18 534948 34104 79175318
Malaise 165.17 11.54 4378 530588 485491 78723931
Lymphoproliferative disorder 164.95 11.54 196 534770 5419 79204003
Dysgeusia 164.63 11.54 89 534877 57088 79152334
Vision blurred 164.37 11.54 286 534680 105612 79103810
Jaundice 164.21 11.54 76 534890 53273 79156149
Rheumatoid nodule 163.96 11.54 362 534604 17076 79192346
Tenosynovitis 163.66 11.54 338 534628 15216 79194206
Malignant melanoma 163.02 11.54 327 534639 14414 79195008
Accidental overdose 161.70 11.54 34 534932 39547 79169875
Subdural haematoma 161.69 11.54 13 534953 31421 79178001
Blood alkaline phosphatase increased 161.29 11.54 115 534851 63549 79145873
Ventricular fibrillation 159.33 11.54 15 534951 31911 79177511
Lymphocyte count decreased 159.06 11.54 59 534907 47230 79162192
Blood calcium decreased 158.66 11.54 15 534951 31804 79177618
Hypothyroidism 157.63 11.54 77 534889 52315 79157107
Irritability 156.88 11.54 41 534925 41103 79168319
Hallucination, visual 156.58 11.54 18 534948 32711 79176711
Disturbance in attention 155.39 11.54 73 534893 50728 79158694
Stevens-Johnson syndrome 155.24 11.54 36 534930 39130 79170292
Lethargy 155.13 11.54 190 534776 81102 79128320
Fluid retention 154.59 11.54 144 534822 69665 79139757
Vein rupture 154.44 11.54 120 534846 1916 79207506
Gastrooesophageal reflux disease 154.22 11.54 290 534676 103956 79105466
Osteonecrosis of jaw 153.91 11.54 49 534917 43177 79166245
Full blood count decreased 153.54 11.54 6 534960 26813 79182609
Adverse event 153.50 11.54 804 534162 59410 79150012
Rash maculo-papular 153.31 11.54 93 534873 55985 79153437
Pulmonary arterial hypertension 150.86 11.54 10 534956 28356 79181066
Suicidal ideation 149.32 11.54 175 534791 76165 79133257
Diarrhoea haemorrhagic 149.26 11.54 296 534670 12938 79196484
Incorrect drug administration rate 148.12 11.54 158 534808 3868 79205554
Therapy interrupted 148.04 11.54 18 534948 31323 79178099
Swollen joint count increased 146.84 11.54 411 534555 22516 79186906
Rectal abscess 146.80 11.54 119 534847 2026 79207396
Labelled drug-drug interaction medication error 146.32 11.54 10 534956 27640 79181782
Therapy cessation 145.98 11.54 36 534930 37526 79171896
Haematemesis 145.23 11.54 85 534881 52179 79157243
Cholestasis 144.44 11.54 85 534881 52024 79157398
Poisoning 143.52 11.54 6 534960 25266 79184156
Eosinophilia 142.06 11.54 63 534903 45282 79164140
Obstructive airways disorder 141.62 11.54 21 534945 31438 79177984
Withdrawal syndrome 141.27 11.54 10 534956 26844 79182578
Neutropenic sepsis 139.75 11.54 11 534955 27053 79182369
Pouchitis 138.42 11.54 85 534881 904 79208518
Myoclonus 138.03 11.54 13 534953 27647 79181775
Psychotic disorder 137.00 11.54 53 534913 41349 79168073
Sinus bradycardia 136.97 11.54 8 534958 25239 79184183
Gastrointestinal inflammation 136.62 11.54 208 534758 7336 79202086
Insomnia 135.86 11.54 1024 533942 244146 78965276
Aphasia 135.64 11.54 72 534894 46660 79162762
Neoplasm malignant 134.97 11.54 495 534471 31315 79178107
Polyarthritis 132.93 11.54 269 534697 11933 79197489
Sinus tachycardia 132.91 11.54 41 534925 36867 79172555
Hepatocellular injury 132.82 11.54 77 534889 47516 79161906
Respiratory depression 132.67 11.54 15 534951 27615 79181807
Abnormal behaviour 131.98 11.54 40 534926 36381 79173041
Ill-defined disorder 131.44 11.54 824 534142 65051 79144371
Blood potassium increased 130.73 11.54 20 534946 29255 79180167
Nephrolithiasis 130.67 11.54 704 534262 52587 79156835
Tremor 130.62 11.54 641 534325 169442 79039980
Gamma-glutamyltransferase increased 130.54 11.54 105 534861 54575 79154847
Loss of consciousness 130.09 11.54 631 534335 167312 79042110
Coagulopathy 129.66 11.54 40 534926 35966 79173456
Myelosuppression 129.40 11.54 54 534912 40242 79169180
Transient ischaemic attack 128.56 11.54 99 534867 52596 79156826
Muscular weakness 128.54 11.54 597 534369 160132 79049290
Generalised tonic-clonic seizure 128.40 11.54 67 534899 43843 79165579
Cardiac disorder 128.33 11.54 151 534815 65606 79143816
Ischaemic stroke 128.27 11.54 32 534934 33099 79176323
Meningitis listeria 127.42 11.54 83 534883 986 79208436
Depression 127.08 11.54 891 534075 215899 78993523
Chest discomfort 126.46 11.54 1450 533516 136594 79072828
Chronic kidney disease 125.82 11.54 155 534811 65999 79143423
Tumour lysis syndrome 125.68 11.54 9 534957 23930 79185492
Apparent death 124.55 11.54 123 534843 2742 79206680
Cerebral infarction 124.51 11.54 76 534890 45600 79163822
Erythema 124.21 11.54 2147 532819 221143 78988279
Pustular psoriasis 123.79 11.54 157 534809 4649 79204773
Anal stenosis 123.75 11.54 62 534904 425 79208997
Extrapyramidal disorder 123.61 11.54 7 534959 22672 79186750
Product quality issue 123.49 11.54 37 534929 33903 79175519
Urinary incontinence 123.26 11.54 60 534906 40849 79168573
Device dislocation 122.46 11.54 15 534951 25955 79183467
Device issue 122.25 11.54 18 534948 27090 79182332
Blood potassium decreased 121.84 11.54 81 534885 46431 79162991
Bone pain 121.06 11.54 117 534849 55625 79153797
Tuberculous pleurisy 120.71 11.54 67 534899 580 79208842
Arrhythmia 120.32 11.54 140 534826 61132 79148290
Ejection fraction decreased 119.94 11.54 41 534925 34536 79174886
Oropharyngeal pain 118.97 11.54 1189 533777 108164 79101258
Circulatory collapse 118.53 11.54 52 534914 37616 79171806
Peripheral swelling 117.37 11.54 2497 532469 267120 78942302
Hallucination, auditory 117.22 11.54 5 534961 20688 79188734
Blister 117.19 11.54 1272 533694 118204 79091218
Demyelination 116.37 11.54 200 534766 7823 79201599
Loss of therapeutic response 116.19 11.54 73 534893 811 79208611
Injection site pruritus 115.75 11.54 70 534896 42213 79167209
Torsade de pointes 115.27 11.54 3 534963 19309 79190113
Restlessness 113.86 11.54 87 534879 46405 79163017
Inappropriate antidiuretic hormone secretion 112.99 11.54 20 534946 26293 79183129
Rash 112.25 11.54 4846 530120 573512 78635910
Drug eruption 112.22 11.54 587 534379 43348 79166074
Product administration error 111.79 11.54 37 534929 31809 79177613
Angioedema 111.16 11.54 213 534753 75822 79133600
Acute hepatic failure 111.08 11.54 32 534934 30081 79179341
Blood sodium decreased 110.99 11.54 42 534924 33213 79176209
Deep vein thrombosis 110.96 11.54 426 534540 120493 79088929
Therapy non-responder 110.96 11.54 1025 533941 91280 79118142
Speech disorder 110.62 11.54 121 534845 54324 79155098
Haemorrhage intracranial 110.13 11.54 21 534945 26172 79183250
Renal tubular necrosis 109.79 11.54 18 534948 25021 79184401
Anuria 109.71 11.54 8 534958 20955 79188467
Subarachnoid haemorrhage 108.60 11.54 17 534949 24448 79184974
Ileectomy 108.43 11.54 44 534922 168 79209254
Right ventricular failure 107.37 11.54 15 534951 23482 79185940
Hepatic encephalopathy 106.80 11.54 17 534949 24149 79185273
Joint destruction 106.79 11.54 163 534803 5762 79203660
Electrolyte imbalance 104.75 11.54 38 534928 30843 79178579
Brain oedema 104.65 11.54 21 534945 25242 79184180
Henoch-Schonlein purpura 104.41 11.54 109 534857 2601 79206821
Leukocytosis 104.29 11.54 83 534883 43372 79166050
Delusion 103.52 11.54 9 534957 20414 79189008
Physical disability 103.34 11.54 119 534847 3179 79206243
Status epilepticus 103.34 11.54 21 534945 25020 79184402
Ankylosing spondylitis 103.25 11.54 243 534723 11962 79197460
Small intestinal resection 103.00 11.54 69 534897 862 79208560
Ulcer 102.58 11.54 436 534530 29536 79179886
Listeriosis 102.30 11.54 99 534867 2151 79207271
Lower respiratory tract infection 102.12 11.54 1320 533646 127900 79081522
Hypocalcaemia 101.38 11.54 111 534855 49813 79159609
Serum sickness 101.21 11.54 124 534842 3542 79205880
Mydriasis 100.82 11.54 4 534962 17639 79191783
Hodgkin's disease 100.62 11.54 66 534900 794 79208628
Cytopenia 100.60 11.54 10 534956 20373 79189049
Asthma 100.36 11.54 515 534451 134580 79074842
Hyperbilirubinaemia 100.28 11.54 21 534945 24497 79184925
Shock 99.80 11.54 87 534879 43461 79165961
Faecal calprotectin abnormal 99.76 11.54 41 534925 163 79209259
Colectomy total 99.51 11.54 49 534917 322 79209100
Hyperlipidaemia 99.49 11.54 26 534940 26067 79183355
Throat tightness 99.45 11.54 411 534555 27496 79181926
Salmonellosis 99.25 11.54 89 534877 1749 79207673
Accidental exposure to product 98.93 11.54 43 534923 31279 79178143
Diabetes mellitus inadequate control 98.79 11.54 21 534945 24243 79185179
Epistaxis 98.41 11.54 399 534567 111116 79098306
Septic shock 98.24 11.54 456 534510 122345 79087077
Antinuclear antibody positive 98.20 11.54 184 534782 7706 79201716
Blood lactate dehydrogenase increased 97.59 11.54 72 534894 39098 79170324
Pneumonitis 97.52 11.54 161 534805 60699 79148723
Injection site bruising 96.30 11.54 80 534886 40922 79168500
Mammoplasty 95.99 11.54 45 534921 261 79209161
Human antichimeric antibody positive 95.69 11.54 83 534883 1558 79207864
Dry skin 95.50 11.54 195 534771 67800 79141622
Impaired quality of life 95.20 11.54 261 534705 14125 79195297
Cutaneous leishmaniasis 94.75 11.54 45 534921 270 79209152
Drug level abnormal 94.44 11.54 47 534919 317 79209105
Tricuspid valve incompetence 93.90 11.54 11 534955 19701 79189721
Haematocrit decreased 93.84 11.54 167 534799 61145 79148277
Atrial flutter 93.81 11.54 16 534950 21609 79187813
B-cell lymphoma 92.87 11.54 157 534809 6058 79203364
Aspartate aminotransferase increased 92.86 11.54 547 534419 138094 79071328
Dystonia 92.46 11.54 16 534950 21383 79188039
Angina pectoris 92.42 11.54 127 534839 51605 79157817
Cardiomegaly 91.83 11.54 31 534935 26321 79183101
Anxiety 91.46 11.54 1147 533819 247365 78962057
Musculoskeletal deformity 91.34 11.54 79 534887 1477 79207945
Urine output decreased 91.19 11.54 8 534958 18014 79191408
Troponin increased 91.09 11.54 11 534955 19244 79190178
Parkinsonism 90.75 11.54 5 534961 16579 79192843
Hypophosphataemia 90.31 11.54 13 534953 19900 79189522
Ataxia 89.83 11.54 28 534938 25011 79184411
Depressed mood 89.68 11.54 116 534850 48364 79161058
Pancreatitis acute 89.40 11.54 121 534845 49483 79159939
Nausea 89.19 11.54 5387 529579 951809 78257613
Dysuria 89.11 11.54 127 534839 50824 79158598
Miosis 88.83 11.54 4 534962 15785 79193637
Emotional distress 87.84 11.54 83 534883 39886 79169536
Glomerular filtration rate decreased 87.75 11.54 22 534944 22680 79186742
Alanine aminotransferase increased 87.65 11.54 684 534282 161886 79047536
Cholangitis sclerosing 87.47 11.54 98 534868 2539 79206883
Left ventricular dysfunction 86.97 11.54 13 534953 19348 79190074
Hypothermia 86.09 11.54 23 534943 22723 79186699
Oliguria 86.00 11.54 6 534960 16303 79193119
Blood pressure diastolic increased 85.68 11.54 253 534713 14289 79195133
Injection site swelling 84.91 11.54 115 534851 47017 79162405
Fibromyalgia 84.79 11.54 729 534237 63611 79145811
Inflammatory bowel disease 84.77 11.54 143 534823 5508 79203914
Rheumatoid factor negative 84.37 11.54 67 534899 1106 79208316
Pseudopolyp 84.18 11.54 47 534919 412 79209010
Contrast media allergy 84.12 11.54 94 534872 2428 79206994
Hemiparesis 84.05 11.54 62 534904 33671 79175751
Red blood cell sedimentation rate 83.72 11.54 141 534825 5424 79203998
Sinusitis 83.54 11.54 1806 533160 193695 79015727
Hypernatraemia 83.53 11.54 3 534963 14448 79194974
Sciatica 82.88 11.54 441 534525 32781 79176641
Aplastic anaemia 82.83 11.54 11 534955 17894 79191528
Acidosis 82.75 11.54 16 534950 19746 79189676
Pulmonary fibrosis 82.58 11.54 543 534423 43569 79165853
Intestinal operation 82.50 11.54 49 534917 488 79208934
Skin necrosis 82.31 11.54 288 534678 17799 79191623
Sleep apnoea syndrome 82.24 11.54 74 534892 36404 79173018
Squamous cell carcinoma 81.98 11.54 261 534705 15361 79194061
Body height below normal 81.66 11.54 84 534882 1969 79207453
Stomatitis 81.51 11.54 1411 533555 145346 79064076
Hidradenitis 80.88 11.54 101 534865 2943 79206479
Mania 80.35 11.54 13 534953 18247 79191175
Lymphopenia 80.32 11.54 53 534913 30504 79178918
Suspected COVID-19 80.14 11.54 102 534864 3031 79206391
Non-Hodgkin's lymphoma 79.46 11.54 72 534894 1435 79207987
Unevaluable event 79.26 11.54 158 534808 55427 79153995
Pericardial effusion 79.14 11.54 117 534849 46120 79163302
Muscle spasticity 78.88 11.54 23 534943 21452 79187970
Proctectomy 78.85 11.54 35 534931 175 79209247
Proctocolectomy 78.82 11.54 33 534933 139 79209283
Extrapulmonary tuberculosis 78.47 11.54 43 534923 362 79209060
Bowel movement irregularity 77.95 11.54 147 534819 6187 79203235
Cardiac failure acute 77.85 11.54 16 534950 18913 79190509
Legionella infection 77.74 11.54 55 534911 755 79208667
Haemodialysis 77.60 11.54 14 534952 18154 79191268
Vascular access complication 77.41 11.54 84 534882 2098 79207324
Blood pressure diastolic decreased 77.37 11.54 404 534562 29812 79179610
Dialysis 77.20 11.54 15 534951 18447 79190975
Paranoia 76.73 11.54 18 534948 19414 79190008
Pyrexia 76.41 11.54 3748 531218 674961 78534461
Nightmare 76.30 11.54 39 534927 25822 79183600
Type 2 diabetes mellitus 75.68 11.54 648 534318 56474 79152948
Epilepsy 75.34 11.54 98 534868 40762 79168660
Haemodynamic instability 75.10 11.54 13 534953 17369 79192053
Muscle twitching 75.09 11.54 36 534930 24728 79184694
Nephropathy toxic 74.76 11.54 22 534944 20397 79189025
Needle issue 74.55 11.54 3 534963 13065 79196357
Infected fistula 74.29 11.54 42 534924 378 79209044
Surgical failure 74.27 11.54 55 534911 814 79208608
Rectal stenosis 74.08 11.54 40 534926 326 79209096
Device malfunction 73.41 11.54 26 534940 21422 79188000
Stoma creation 73.30 11.54 26 534940 61 79209361
Hypovolaemia 72.67 11.54 15 534951 17676 79191746
Schizophrenia 72.60 11.54 9 534957 15431 79193991
Intestinal fistula 72.50 11.54 67 534899 1371 79208051
Skin exfoliation 72.40 11.54 164 534802 54936 79154486
Renal injury 72.39 11.54 13 534953 16914 79192508
Visual acuity reduced 72.35 11.54 55 534911 29414 79180008
Prothrombin time prolonged 72.22 11.54 13 534953 16886 79192536
Thirst 72.05 11.54 18 534948 18601 79190821
Myocardial ischaemia 71.61 11.54 41 534925 25478 79183944
Blood pressure diastolic abnormal 71.58 11.54 20 534946 19182 79190240
IgA nephropathy 71.52 11.54 73 534893 1695 79207727
Arteriosclerosis coronary artery 71.36 11.54 16 534950 17800 79191622
Chromaturia 71.35 11.54 42 534924 25704 79183718
Shock haemorrhagic 70.95 11.54 23 534943 20037 79189385
Sudden death 70.94 11.54 31 534935 22480 79186942
Arthrodesis 70.67 11.54 84 534882 2323 79207099
Mental impairment 70.64 11.54 20 534946 19016 79190406
Blood loss anaemia 70.56 11.54 10 534956 15488 79193934
Product prescribing error 70.45 11.54 120 534846 44693 79164729
Contraindication to vaccination 70.45 11.54 33 534933 191 79209231
Activated partial thromboplastin time prolonged 70.17 11.54 7 534959 14221 79195201
Cholelithiasis 69.81 11.54 156 534810 52508 79156914
Coeliac disease 69.29 11.54 200 534766 11151 79198271
Eosinophil count increased 69.24 11.54 15 534951 17090 79192332
Tuberculin test positive 68.96 11.54 99 534867 3309 79206113
Pollakiuria 68.29 11.54 90 534876 37227 79172195
Blood glucose decreased 68.28 11.54 46 534920 26188 79183234
Thrombotic microangiopathy 68.10 11.54 25 534941 20144 79189278
Aspiration 68.04 11.54 25 534941 20133 79189289
Grip strength decreased 67.91 11.54 309 534657 21560 79187862
Tinnitus 67.62 11.54 121 534845 44212 79165210
Supraventricular tachycardia 67.49 11.54 29 534937 21241 79188181
Deformity 67.32 11.54 178 534788 9427 79199995
Joint stiffness 67.21 11.54 487 534479 40343 79169079
Dermatitis psoriasiform 66.84 11.54 88 534878 2706 79206716
Muscle rigidity 66.53 11.54 25 534941 19857 79189565
Cardiomyopathy 66.52 11.54 57 534909 28717 79180705
Atlantoaxial instability 66.43 11.54 35 534931 270 79209152
Oxygen saturation abnormal 66.16 11.54 114 534852 4468 79204954
Infusion site reaction 65.66 11.54 98 534868 3395 79206027
Anorectal disorder 65.65 11.54 79 534887 2214 79207208
Drug use disorder 65.45 11.54 165 534801 8486 79200936
Myelodysplastic syndrome 65.33 11.54 64 534902 30237 79179185
Ear infection bacterial 65.25 11.54 28 534938 127 79209295
Atelectasis 65.18 11.54 72 534894 32185 79177237
Dry mouth 65.09 11.54 336 534630 87683 79121739
Femur fracture 65.00 11.54 99 534867 38553 79170869
Mineral metabolism disorder 64.95 11.54 35 534931 284 79209138
Pulseless electrical activity 64.79 11.54 9 534957 14151 79195271
Blood uric acid increased 64.78 11.54 7 534959 13353 79196069
Gastritis 64.57 11.54 141 534825 47852 79161570
Infectious mononucleosis 64.52 11.54 74 534892 1968 79207454
Anal cancer 64.36 11.54 49 534917 758 79208664
Mitral valve incompetence 64.33 11.54 58 534908 28507 79180915
Mesenteritis 64.25 11.54 36 534930 318 79209104
Blood pressure systolic abnormal 64.22 11.54 18 534948 17229 79192193
Rectal haemorrhage 63.91 11.54 788 534178 75512 79133910
Psychomotor hyperactivity 63.84 11.54 17 534949 16832 79192590
Fear 63.61 11.54 34 534932 21952 79187470
Paradoxical psoriasis 63.55 11.54 32 534934 222 79209200
Red blood cell count decreased 63.42 11.54 187 534779 57326 79152096
White blood cell count increased 63.38 11.54 271 534695 74362 79135060
Hiatus hernia 63.24 11.54 39 534927 23273 79186149
Diplopia 63.02 11.54 79 534887 33387 79176035
End stage renal disease 63.00 11.54 5 534961 12215 79197207
Clear cell renal cell carcinoma 62.97 11.54 82 534884 2494 79206928
Treatment noncompliance 62.81 11.54 163 534803 52105 79157317
Atrioventricular block complete 62.47 11.54 17 534949 16593 79192829
Antibody test positive 62.30 11.54 85 534881 2707 79206715
Respiratory distress 61.96 11.54 193 534773 58146 79151276
Atrioventricular block 61.77 11.54 10 534956 14031 79195391
Abscess intestinal 61.76 11.54 84 534882 2667 79206755
Infective pulmonary exacerbation of cystic fibrosis 61.64 11.54 7 534959 12844 79196578
Head injury 61.61 11.54 97 534869 37272 79172150
Subcutaneous abscess 61.60 11.54 153 534813 7796 79201626
White coat hypertension 61.60 11.54 49 534917 811 79208611
Dislocation of vertebra 61.41 11.54 152 534814 7728 79201694
Granulocytopenia 60.88 11.54 4 534962 11427 79197995
Device occlusion 60.77 11.54 5 534961 11861 79197561
Metastases to bone 60.72 11.54 45 534921 24382 79185040
Hepatotoxicity 60.30 11.54 162 534804 51190 79158232
Steroid dependence 60.10 11.54 81 534885 2549 79206873
Alanine aminotransferase abnormal 59.80 11.54 162 534804 8705 79200717
Affect lability 59.78 11.54 4 534962 11255 79198167
Intestinal sepsis 59.68 11.54 49 534917 850 79208572
Polyuria 59.10 11.54 14 534952 15000 79194422
Hyperthyroidism 59.08 11.54 38 534928 22171 79187251
Renal disorder 58.91 11.54 121 534845 41984 79167438
Transfusion 58.82 11.54 35 534931 21295 79188127
Hysterectomy 58.73 11.54 130 534836 6142 79203280
Hyperammonaemia 58.73 11.54 4 534962 11089 79198333
Injection site mass 58.71 11.54 31 534935 20153 79189269
Rectal tenesmus 58.58 11.54 64 534902 1611 79207811
Salivary hypersecretion 58.55 11.54 12 534954 14212 79195210
Enterostomy 57.86 11.54 30 534936 223 79209199
Device difficult to use 57.85 11.54 10 534956 13375 79196047
Proteinuria 57.85 11.54 80 534886 32422 79177000
Rales 57.77 11.54 31 534935 19970 79189452
Injection site rash 57.74 11.54 24 534942 17930 79191492
Tuberculosis gastrointestinal 57.48 11.54 40 534926 534 79208888
Device leakage 57.23 11.54 4 534962 10852 79198570
Haemolytic anaemia 57.02 11.54 24 534942 17796 79191626
Blood phosphorus increased 56.99 11.54 3 534963 10344 79199078
Hypoacusis 56.95 11.54 71 534895 30079 79179343
Diastolic dysfunction 56.94 11.54 4 534962 10807 79198615
Wheezing 56.91 11.54 504 534462 116160 79093262
Respiratory tract infection 56.87 11.54 154 534812 48535 79160887
Polyneuropathy 56.86 11.54 47 534919 24104 79185318
Gastric ulcer 56.86 11.54 87 534879 33818 79175604
Pericarditis tuberculous 56.64 11.54 23 534943 88 79209334
Pharyngeal paraesthesia 56.47 11.54 80 534886 2641 79206781
Oesophagitis 56.29 11.54 48 534918 24241 79185181
Blood lactic acid increased 56.24 11.54 9 534957 12735 79196687
DNA antibody positive 56.23 11.54 32 534934 292 79209130
Coordination abnormal 55.90 11.54 23 534943 17289 79192133
Illness 55.63 11.54 516 534450 45995 79163427
Decubitus ulcer 55.46 11.54 18 534948 15669 79193753
Toxic encephalopathy 55.46 11.54 6 534960 11434 79197988
Feeling hot 55.36 11.54 629 534337 59105 79150317
Immune thrombocytopenia 55.35 11.54 25 534941 17780 79191642
Proctalgia 55.16 11.54 170 534796 9831 79199591
X-ray abnormal 55.01 11.54 121 534845 5692 79203730
Tonsillitis 54.98 11.54 132 534834 6582 79202840
Ventricular extrasystoles 54.80 11.54 32 534934 19672 79189750
COVID-19 pneumonia 54.42 11.54 68 534898 28781 79180641
Small intestinal stenosis 54.37 11.54 45 534921 790 79208632
Duodenal ulcer 54.08 11.54 21 534945 16348 79193074
Joint injury 54.04 11.54 378 534588 30957 79178465
Acute myeloid leukaemia 53.99 11.54 77 534889 30808 79178614
Respiratory acidosis 53.98 11.54 6 534960 11194 79198228
Tongue disorder 53.93 11.54 211 534755 13764 79195658
Fear of injection 53.90 11.54 140 534826 7334 79202088
SARS-CoV-2 test positive 53.70 11.54 187 534779 11529 79197893
Spinal instability 53.65 11.54 35 534931 417 79209005
No adverse event 53.64 11.54 105 534861 37087 79172335
Disseminated intravascular coagulation 53.62 11.54 99 534867 35743 79173679
Injection site induration 53.61 11.54 3 534963 9816 79199606
Febrile bone marrow aplasia 53.56 11.54 11 534955 13009 79196413
Tubulointerstitial nephritis 53.39 11.54 110 534856 38125 79171297
Systemic infection 53.18 11.54 3 534963 9749 79199673
Antinuclear antibody increased 53.17 11.54 52 534914 1145 79208277
Type IV hypersensitivity reaction 53.09 11.54 97 534869 3984 79205438
Tachypnoea 53.08 11.54 83 534883 31980 79177442
T-cell lymphoma 53.07 11.54 54 534912 1249 79208173
Hepatitis acute 52.92 11.54 19 534947 15523 79193899
Hyperuricaemia 52.82 11.54 8 534958 11791 79197631
Blood iron abnormal 52.70 11.54 55 534911 1312 79208110
Bronchitis chronic 52.67 11.54 102 534864 4380 79205042
Thinking abnormal 52.35 11.54 12 534954 13149 79196273
Faeces soft 52.12 11.54 148 534818 8175 79201247
Joint range of motion decreased 51.94 11.54 392 534574 32890 79176532
Colitis ischaemic 51.92 11.54 19 534947 15340 79194082
Pharyngitis streptococcal 51.72 11.54 174 534792 10540 79198882
Erectile dysfunction 51.54 11.54 17 534949 14647 79194775
Bronchitis 51.45 11.54 594 534372 130050 79079372
Electrocardiogram abnormal 51.26 11.54 24 534942 16713 79192709
Glycosylated haemoglobin increased 51.17 11.54 33 534933 19227 79190195
Cutaneous T-cell lymphoma 51.04 11.54 76 534890 2627 79206795
Metastases to central nervous system 50.90 11.54 23 534943 16352 79193070
Acute pulmonary oedema 50.89 11.54 16 534950 14214 79195208
Abdominal abscess 50.89 11.54 133 534833 6994 79202428
Neutrophil count increased 50.69 11.54 74 534892 29322 79180100
Ileocaecal resection 50.55 11.54 22 534944 104 79209318
Toxic skin eruption 50.52 11.54 45 534921 22248 79187174
Abnormal dreams 50.49 11.54 8 534958 11404 79198018
Anaphylactic reaction 50.45 11.54 816 534150 82927 79126495
Lymphoedema 50.01 11.54 11 534955 12402 79197020
Perirectal abscess 49.94 11.54 65 534901 1976 79207446
Onychomycosis 49.89 11.54 145 534821 8116 79201306
Lipase increased 49.83 11.54 24 534942 16442 79192980
Ankle deformity 49.79 11.54 40 534926 672 79208750
Petechiae 49.70 11.54 39 534927 20526 79188896
Wheelchair user 49.61 11.54 120 534846 6012 79203410
Posterior reversible encephalopathy syndrome 49.52 11.54 62 534904 26219 79183203
Blood triglycerides increased 49.47 11.54 41 534925 20999 79188423
Swollen tongue 49.45 11.54 135 534831 42435 79166987
Anticipatory anxiety 49.23 11.54 50 534916 1154 79208268
Wisdom teeth removal 49.04 11.54 34 534932 451 79208971
Myalgia 49.03 11.54 913 534053 184728 79024694
Enterocutaneous fistula 48.84 11.54 63 534903 1898 79207524
Graft versus host disease 48.46 11.54 20 534946 15006 79194416
Pulmonary haemorrhage 48.42 11.54 19 534947 14698 79194724
Bronchitis bacterial 48.42 11.54 55 534911 1447 79207975
Device breakage 48.34 11.54 7 534959 10668 79198754
Cytomegalovirus colitis 48.34 11.54 101 534865 4584 79204838
Haemorrhagic stroke 48.30 11.54 8 534958 11038 79198384
Acute generalised exanthematous pustulosis 48.02 11.54 28 534938 17226 79192196
Double stranded DNA antibody 47.89 11.54 17 534949 40 79209382
Amyotrophic lateral sclerosis 47.87 11.54 60 534906 1755 79207667
Peripheral sensory neuropathy 47.79 11.54 14 534952 13019 79196403
Hydronephrosis 47.62 11.54 29 534937 17425 79191997
Joint arthroplasty 47.45 11.54 74 534892 2666 79206756
Sensitivity to weather change 47.41 11.54 140 534826 7907 79201515
Hypoalbuminaemia 47.06 11.54 44 534922 21253 79188169
Hepatitis cholestatic 47.06 11.54 17 534949 13835 79195587
Concomitant disease aggravated 46.74 11.54 15 534951 13152 79196270
Rheumatoid lung 46.73 11.54 94 534872 4151 79205271
Visual impairment 46.72 11.54 394 534572 91737 79117685
Acute respiratory distress syndrome 46.65 11.54 146 534820 43921 79165501
Sports injury 46.48 11.54 23 534943 153 79209269
Gait disturbance 46.07 11.54 1050 533916 206456 79002966
Ankle operation 45.88 11.54 46 534920 1045 79208377
Neuralgia 45.81 11.54 97 534869 33287 79176135
Vaginal fistula 45.79 11.54 27 534939 265 79209157
Blood cholesterol increased 45.76 11.54 803 534163 82917 79126505
Acute graft versus host disease 45.27 11.54 7 534959 10160 79199262
Bundle branch block right 45.27 11.54 10 534956 11241 79198181
Hypercapnia 45.12 11.54 4 534962 8931 79200491
Pathogen resistance 44.80 11.54 20 534946 14322 79195100
Dementia 44.59 11.54 60 534906 24599 79184823
Sleep disorder due to a general medical condition 44.46 11.54 20 534946 14257 79195165
Hip fracture 44.23 11.54 87 534879 30674 79178748
Apathy 43.96 11.54 16 534950 12961 79196461
Complication associated with device 43.79 11.54 32 534934 17464 79191958
Varicella 43.72 11.54 74 534892 2858 79206564
Lower gastrointestinal haemorrhage 43.71 11.54 27 534939 16098 79193324
Blindness 43.71 11.54 77 534889 28306 79181116
Myopathy 43.68 11.54 44 534922 20519 79188903
Fine motor skill dysfunction 43.52 11.54 105 534861 5252 79204170
Joint effusion 43.49 11.54 237 534729 17777 79191645
Stress 43.30 11.54 763 534203 78849 79130573
Personality change 43.08 11.54 8 534958 10162 79199260
Substance abuse 43.08 11.54 9 534957 10517 79198905
Angina unstable 42.99 11.54 29 534937 16498 79192924
Nocturia 42.86 11.54 19 534947 13662 79195760
Protein urine present 42.74 11.54 8 534958 10104 79199318
Device related infection 42.72 11.54 105 534861 34189 79175233
Injection site warmth 42.69 11.54 23 534943 14784 79194638
Post transplant lymphoproliferative disorder 42.62 11.54 12 534954 11452 79197970
Arteriosclerosis 42.26 11.54 36 534930 18191 79191231
Hiccups 42.26 11.54 8 534958 10023 79199399
Terminal state 42.07 11.54 98 534868 4791 79204631
Cervix carcinoma 42.05 11.54 63 534903 2190 79207232
Retinitis 42.04 11.54 107 534859 5536 79203886
Plasmablastic lymphoma 42.03 11.54 32 534934 495 79208927
Pneumocystis jirovecii pneumonia 41.61 11.54 366 534600 32142 79177280
Liver disorder 41.54 11.54 700 534266 71717 79137705
Coronary artery stenosis 41.27 11.54 16 534950 12468 79196954
Productive cough 41.16 11.54 386 534580 87945 79121477
Blood creatine increased 41.00 11.54 7 534959 9448 79199974
Stress cardiomyopathy 40.94 11.54 12 534954 11154 79198268
Listeria sepsis 40.93 11.54 37 534929 735 79208687
Serum ferritin decreased 40.83 11.54 64 534902 2316 79207106
Aplasia pure red cell 40.82 11.54 3 534963 7807 79201615
Abortion spontaneous 40.81 11.54 338 534628 29169 79180253
Stoma obstruction 40.75 11.54 24 534942 235 79209187
Hepatic cytolysis 40.61 11.54 75 534891 27076 79182346
Premature delivery 40.53 11.54 59 534907 23408 79186014
Mood altered 40.47 11.54 36 534930 17811 79191611
Cholecystitis acute 40.11 11.54 20 534946 13431 79195991
Impaired work ability 39.75 11.54 247 534719 19434 79189988
Cervical dysplasia 39.72 11.54 60 534906 2101 79207321
Pulmonary function test decreased 39.72 11.54 3 534963 7634 79201788
Ear infection 39.68 11.54 379 534587 34053 79175369
Ventricular arrhythmia 39.56 11.54 6 534960 8834 79200588
Cholecystitis chronic 39.46 11.54 9 534957 9897 79199525
Nystagmus 39.45 11.54 9 534957 9895 79199527
Mixed liver injury 39.35 11.54 3 534963 7575 79201847
Left ventricular hypertrophy 39.28 11.54 13 534953 11178 79198244
Intestinal ischaemia 39.16 11.54 20 534946 13250 79196172
Hypomania 39.14 11.54 3 534963 7541 79201881
Hypogammaglobulinaemia 39.00 11.54 19 534947 12932 79196490
Anal fistula infection 38.95 11.54 17 534949 81 79209341
Cerebral haematoma 38.92 11.54 4 534962 7938 79201484
Osteonecrosis 38.89 11.54 95 534871 31000 79178422
Nail disorder 38.70 11.54 170 534796 11682 79197740
Coma scale abnormal 38.59 11.54 6 534960 8672 79200750
Iritis 38.49 11.54 82 534884 3773 79205649
Coronary artery occlusion 38.35 11.54 28 534938 15287 79194135
Incorrect dosage administered 38.29 11.54 68 534898 2731 79206691
Hypertransaminasaemia 38.25 11.54 16 534950 11908 79197514
Staphylococcal bacteraemia 38.23 11.54 17 534949 12201 79197221
Adjustment disorder with depressed mood 38.21 11.54 141 534825 8945 79200477
Embolic stroke 38.21 11.54 4 534962 7822 79201600
Jaundice cholestatic 38.08 11.54 14 534952 11270 79198152
Colostomy 38.07 11.54 42 534924 1069 79208353
Bradyphrenia 37.99 11.54 12 534954 10628 79198794
Ventricular hypokinesia 37.84 11.54 8 534958 9271 79200151
Medication error 37.82 11.54 287 534679 68355 79141067
Pulmonary congestion 37.81 11.54 78 534888 27022 79182400
Injection site haemorrhage 37.39 11.54 82 534884 27788 79181634
International normalised ratio decreased 37.23 11.54 5 534961 8065 79201357
Lung neoplasm malignant 37.19 11.54 316 534650 27476 79181946
Wound infection 37.12 11.54 282 534684 23709 79185713
Bradykinesia 37.07 11.54 5 534961 8038 79201384
Facet joint syndrome 36.82 11.54 162 534804 11140 79198282
Cytology abnormal 36.74 11.54 25 534941 321 79209101
Paraesthesia 36.70 11.54 901 534065 175422 79034000
Intestinal anastomosis 36.66 11.54 33 534933 652 79208770
Exercise tolerance decreased 36.62 11.54 8 534958 9063 79200359
Onychomadesis 36.59 11.54 97 534869 5145 79204277
Tachycardia 36.56 11.54 910 534056 176858 79032564
Diffuse large B-cell lymphoma 36.49 11.54 170 534796 11979 79197443
Guttate psoriasis 36.46 11.54 28 534938 439 79208983
Blood thyroid stimulating hormone increased 36.39 11.54 10 534956 9698 79199724
Suffocation feeling 36.33 11.54 51 534915 1669 79207753
Femoral neck fracture 36.11 11.54 11 534955 9973 79199449
Amylase increased 36.02 11.54 15 534951 11194 79198228
Dry eye 35.90 11.54 127 534839 36804 79172618
Gastrointestinal scarring 35.84 11.54 25 534941 335 79209087
Atypical mycobacterial infection 35.81 11.54 51 534915 1692 79207730
Hypoxic-ischaemic encephalopathy 35.71 11.54 5 534961 7815 79201607
Fistula repair 35.68 11.54 15 534951 64 79209358
Chronic recurrent multifocal osteomyelitis 35.68 11.54 15 534951 64 79209358
Hypotonia 35.65 11.54 21 534945 12849 79196573
Peritonitis bacterial 35.59 11.54 10 534956 9557 79199865
Gout 35.58 11.54 70 534896 24679 79184743
Blood chloride decreased 35.58 11.54 6 534960 8171 79201251
Feeling abnormal 35.49 11.54 805 534161 158394 79051028
Sinus disorder 35.45 11.54 60 534906 22404 79187018
Seronegative arthritis 34.99 11.54 89 534877 4603 79204819
Blood calcium increased 34.93 11.54 13 534953 10387 79199035
Oxygen saturation decreased 34.90 11.54 632 534334 128415 79081007
Ageusia 34.86 11.54 36 534930 16596 79192826
Orthopnoea 34.84 11.54 12 534954 10061 79199361
Spinal column injury 34.82 11.54 57 534909 2141 79207281
Spleen tuberculosis 34.79 11.54 12 534954 25 79209397
Clonus 34.71 11.54 3 534963 6837 79202585
Hepatic function abnormal 34.69 11.54 318 534648 72789 79136633
Dysphonia 34.64 11.54 231 534735 56641 79152781
Gastric haemorrhage 34.56 11.54 30 534936 15020 79194402
Temperature intolerance 34.55 11.54 11 534955 9694 79199728
Interstitial lung disease 34.51 11.54 539 534427 112061 79097361
Opportunistic infection 34.50 11.54 67 534899 2883 79206539
Injection site discolouration 34.46 11.54 5 534961 7609 79201813
Chest pain 34.42 11.54 1545 533421 280759 78928663
Gastric ulcer haemorrhage 34.40 11.54 9 534957 9018 79200404
Neoplasm skin 34.38 11.54 48 534918 1563 79207859
Endometriosis 34.32 11.54 76 534890 3592 79205830
Fistula inflammation 34.29 11.54 10 534956 8 79209414
Musculoskeletal disorder 34.25 11.54 254 534712 21194 79188228
Heart rate increased 34.16 11.54 1056 533910 119668 79089754
Hair follicle tumour benign 34.14 11.54 27 534939 443 79208979
Partial seizures 34.12 11.54 9 534957 8969 79200453
Hemiplegia 34.04 11.54 30 534936 14909 79194513
Azotaemia 34.03 11.54 7 534959 8269 79201153
Low density lipoprotein increased 34.02 11.54 8 534958 8614 79200808
Anorectal discomfort 33.99 11.54 75 534891 3536 79205886
Skin ulcer 33.87 11.54 531 534435 53619 79155803
Intestinal ulcer 33.85 11.54 54 534912 1984 79207438
Red cell distribution width decreased 33.85 11.54 54 534912 1984 79207438
Vasectomy 33.75 11.54 10 534956 9 79209413
Product monitoring error 33.71 11.54 9 534957 8897 79200525
Brain natriuretic peptide increased 33.68 11.54 9 534957 8891 79200531
Dyslipidaemia 33.64 11.54 18 534948 11615 79197807
Product use in unapproved indication 33.62 11.54 2026 532940 248333 78961089
Drug tolerance 33.49 11.54 131 534835 8544 79200878
Proctitis 33.33 11.54 107 534859 6325 79203097
Lung squamous cell carcinoma recurrent 33.25 11.54 10 534956 10 79209412
Intestinal tuberculosis 33.11 11.54 20 534946 206 79209216
Brain injury 33.04 11.54 18 534948 11499 79197923
Drug level increased 33.03 11.54 145 534821 39506 79169916
Bundle branch block left 33.02 11.54 18 534948 11495 79197927
Tooth infection 32.96 11.54 228 534738 18604 79190818
Erythema multiforme 32.88 11.54 42 534924 17609 79191813
Adverse drug reaction 32.85 11.54 627 534339 65765 79143657
Electrocardiogram ST segment elevation 32.72 11.54 8 534958 8389 79201033
Anastomotic ulcer 32.71 11.54 32 534934 705 79208717
Hypovolaemic shock 32.66 11.54 21 534945 12255 79197167
Product complaint 32.66 11.54 25 534941 13324 79196098
Rhinitis allergic 32.63 11.54 21 534945 12248 79197174
Oedema 32.53 11.54 585 534381 118995 79090427
Vein collapse 32.52 11.54 39 534927 1089 79208333
Malignant respiratory tract neoplasm 32.52 11.54 11 534955 21 79209401
Joint ankylosis 32.48 11.54 55 534911 2125 79207297
Maternal exposure timing unspecified 32.45 11.54 99 534867 5693 79203729
Coccidioidomycosis 32.44 11.54 42 534924 1270 79208152
Skin discolouration 32.43 11.54 153 534813 40881 79168541
SAPHO syndrome 32.34 11.54 25 534941 396 79209026
Stupor 32.32 11.54 4 534962 6868 79202554
Faecal calprotectin decreased 32.28 11.54 17 534949 131 79209291
Depressive symptom 32.10 11.54 3 534963 6420 79203002
Epstein-Barr virus associated lymphoma 31.97 11.54 38 534928 1051 79208371
Deep vein thrombosis postoperative 31.96 11.54 150 534816 10602 79198820
Faeces discoloured 31.90 11.54 95 534871 29032 79180390
Hyperphosphataemia 31.80 11.54 3 534963 6373 79203049
Anal fissure haemorrhage 31.77 11.54 13 534953 51 79209371
Duodenal ulcer haemorrhage 31.74 11.54 5 534961 7158 79202264
Wrist surgery 31.73 11.54 33 534933 784 79208638
Pulse absent 31.70 11.54 14 534952 10089 79199333
Metabolic disorder 31.58 11.54 11 534955 9159 79200263
Hypertension 31.50 11.54 2604 532362 328388 78881034
Lip swelling 31.48 11.54 154 534812 40757 79168665
Anastomotic stenosis 31.47 11.54 27 534939 499 79208923
Injection site urticaria 31.40 11.54 24 534942 12802 79196620
Hypertensive crisis 31.39 11.54 57 534909 20713 79188709
Muscle haemorrhage 31.33 11.54 3 534963 6297 79203125
Vertigo 31.28 11.54 304 534662 68778 79140644
Surgery 31.25 11.54 347 534619 32419 79177003
Bone disorder 31.14 11.54 50 534916 19063 79190359
Hepatomegaly 31.10 11.54 49 534917 18825 79190597
Premature labour 31.03 11.54 125 534841 8265 79201157
Caesarean section 30.99 11.54 166 534800 12369 79197053
Gastrointestinal stenosis 30.96 11.54 20 534946 234 79209188
Pathological fracture 30.92 11.54 16 534950 10521 79198901
Obliterative bronchiolitis 30.92 11.54 65 534901 2963 79206459
Bursitis 30.80 11.54 372 534594 35472 79173950
Ileus paralytic 30.71 11.54 13 534953 9607 79199815
Mouth ulceration 30.64 11.54 393 534573 38001 79171421
Psychomotor retardation 30.61 11.54 3 534963 6181 79203241
Colon dysplasia 30.55 11.54 19 534947 207 79209215
Ankle arthroplasty 30.42 11.54 44 534922 1481 79207941
Personality disorder 30.37 11.54 3 534963 6143 79203279
Cell marker increased 30.27 11.54 29 534937 622 79208800
Aortic arteriosclerosis 30.20 11.54 11 534955 8907 79200515
Pregnancy of partner 30.19 11.54 20 534946 245 79209177
Peripheral arterial occlusive disease 30.05 11.54 9 534957 8249 79201173
Secretion discharge 30.01 11.54 188 534778 14834 79194588
Cerebral ischaemia 29.99 11.54 19 534947 11176 79198246
Apnoea 29.83 11.54 21 534945 11683 79197739
Nephropathy 29.77 11.54 14 534952 9724 79199698
Arthritis enteropathic 29.70 11.54 21 534945 288 79209134
Blood glucose abnormal 29.61 11.54 17 534949 10549 79198873
Respiratory syncytial virus infection 29.54 11.54 13 534953 9389 79200033
Lupus vasculitis 29.44 11.54 27 534939 547 79208875
General physical health deterioration 29.41 11.54 2185 532781 273053 78936369
Antibody test abnormal 29.34 11.54 29 534937 647 79208775
Transaminases increased 29.14 11.54 215 534751 51528 79157894
Swelling face 29.12 11.54 321 534645 70891 79138531
Gastroenteritis salmonella 29.12 11.54 36 534930 1038 79208384
Sexual dysfunction 29.09 11.54 8 534958 7755 79201667
Drooling 29.05 11.54 3 534963 5931 79203491
Pruritus 29.02 11.54 3048 531918 391600 78817822
Pemphigoid 28.99 11.54 36 534930 15279 79194143
Abnormal faeces 28.96 11.54 114 534852 7457 79201965
Pain in jaw 28.84 11.54 186 534780 45965 79163457
Rectal cancer 28.69 11.54 69 534897 3444 79205978
Incoherent 28.69 11.54 8 534958 7684 79201738
Gynaecomastia 28.63 11.54 8 534958 7673 79201749
Latent tuberculosis 28.62 11.54 67 534899 3286 79206136
Nasal polyps 28.51 11.54 7 534959 7320 79202102
Purpura 28.27 11.54 55 534911 19472 79189950
Ventricular hypertrophy 28.25 11.54 6 534960 6932 79202490
Metastases to lung 28.22 11.54 49 534917 18114 79191308
Anti-cyclic citrullinated peptide antibody 28.21 11.54 95 534871 5757 79203665
Blood magnesium decreased 28.04 11.54 42 534924 16470 79192952
Joint dislocation 27.85 11.54 202 534764 16737 79192685
Spinal osteoarthritis 27.84 11.54 44 534922 16883 79192539
Large intestinal ulcer 27.82 11.54 83 534883 4714 79204708
Colon injury 27.79 11.54 19 534947 246 79209176
Cytomegalovirus infection 27.76 11.54 421 534545 42223 79167199
Performance status decreased 27.70 11.54 4 534962 6109 79203313
Renal tubular disorder 27.70 11.54 5 534961 6481 79202941
Drug specific antibody absent 27.69 11.54 18 534948 213 79209209
Enterocolitis 27.59 11.54 34 534932 14478 79194944
Tonsillar ulcer 27.59 11.54 23 534943 408 79209014
Bladder neoplasm 27.45 11.54 45 534921 1692 79207730
Brain herniation 27.40 11.54 8 534958 7455 79201967
Gastrointestinal stoma complication 27.38 11.54 57 534909 2580 79206842
Blood pressure systolic increased 27.37 11.54 615 534351 66371 79143051
Pneumonia cryptococcal 27.34 11.54 42 534924 1493 79207929
Dysstasia 27.25 11.54 95 534871 27651 79181771
Drug exposure before pregnancy 27.23 11.54 27 534939 605 79208817
Taste disorder 27.11 11.54 40 534926 15783 79193639
Drug abuser 27.10 11.54 4 534962 6009 79203413
Granuloma 27.09 11.54 119 534847 8178 79201244
Euphoric mood 27.08 11.54 9 534957 7717 79201705
Restless legs syndrome 27.05 11.54 59 534907 20033 79189389
Vaginal haemorrhage 27.01 11.54 67 534899 21750 79187672
Venous injury 26.94 11.54 30 534936 772 79208650
Ileus 26.93 11.54 88 534878 26123 79183299
Neck deformity 26.91 11.54 46 534920 1791 79207631
Breast cancer stage I 26.87 11.54 6 534960 6694 79202728
Pseudomonas infection 26.83 11.54 63 534903 20840 79188582
Blood glucose fluctuation 26.76 11.54 6 534960 6676 79202746
Ophthalmic herpes zoster 26.69 11.54 57 534909 2627 79206795
Autoimmune disorder 26.68 11.54 197 534769 16415 79193007
Neurogenic shock 26.59 11.54 27 534939 623 79208799
Pus in stool 26.57 11.54 12 534954 63 79209359
Bone cyst 26.52 11.54 66 534900 3367 79206055
Urosepsis 26.50 11.54 90 534876 26405 79183017
Osteoarthritis 26.39 11.54 770 534196 86539 79122883
Disseminated coccidioidomycosis 26.35 11.54 15 534951 137 79209285
Oral mucosal blistering 26.30 11.54 5 534961 6246 79203176
Carotid artery stenosis 26.15 11.54 13 534953 8745 79200677
Streptococcal infection 26.11 11.54 123 534843 8707 79200715
Torus fracture 26.08 11.54 13 534953 88 79209334
Drain placement 26.08 11.54 15 534951 140 79209282
Therapy partial responder 26.07 11.54 48 534918 17349 79192073
Myasthenia gravis 26.05 11.54 19 534947 10380 79199042
Pyoderma 26.03 11.54 23 534943 443 79208979
Left ventricular failure 26.03 11.54 16 534950 9565 79199857
Occult blood positive 25.97 11.54 7 534959 6876 79202546
Aplasia 25.89 11.54 10 534956 7810 79201612
Superficial spreading melanoma stage unspecified 25.78 11.54 19 534947 279 79209143
Product dose omission in error 25.71 11.54 10 534956 7778 79201644
Progressive multifocal leukoencephalopathy 25.71 11.54 63 534903 20537 79188885
Hodgkin's disease nodular sclerosis 25.70 11.54 9 534957 20 79209402
Autoimmune haemolytic anaemia 25.69 11.54 12 534954 8368 79201054
Gastritis erosive 25.67 11.54 21 534945 10826 79198596
Lung consolidation 25.64 11.54 14 534952 8933 79200489
Cutaneous lupus erythematosus 25.63 11.54 60 534906 2943 79206479
Diverticulitis 25.60 11.54 442 534524 45494 79163928
Gingival graft 25.60 11.54 7 534959 3 79209419
Vitamin D deficiency 25.56 11.54 35 534931 14244 79195178
Failure to thrive 25.55 11.54 25 534941 11819 79197603
Generalised oedema 25.48 11.54 78 534888 23631 79185791
Haemolysis 25.45 11.54 29 534937 12783 79196639
Lip dry 25.43 11.54 184 534782 15234 79194188
Insurance issue 25.41 11.54 4 534962 5729 79203693
Hydrocephalus 25.40 11.54 14 534952 8886 79200536
Ileostomy closure 25.39 11.54 19 534947 286 79209136
Extrasystoles 25.38 11.54 9 534957 7410 79202012
Eyelid ptosis 25.38 11.54 22 534944 11022 79198400
Skin burning sensation 25.33 11.54 31 534935 13241 79196181
Eye movement disorder 25.29 11.54 11 534955 8000 79201422
Rib fracture 25.27 11.54 99 534867 27848 79181574
Myocarditis 25.18 11.54 69 534897 21664 79187758
Leishmaniasis 25.17 11.54 21 534945 373 79209049
Hypertriglyceridaemia 25.13 11.54 29 534937 12711 79196711
Amnesia 25.09 11.54 286 534680 62771 79146651
Coronary arterial stent insertion 25.08 11.54 5 534961 6039 79203383
Peritonsillar abscess 25.05 11.54 31 534935 895 79208527
Product storage error 25.00 11.54 44 534922 16182 79193240
Thrombosis 24.95 11.54 405 534561 83695 79125727
Dyspepsia 24.95 11.54 547 534419 108140 79101282
Epicondylitis 24.90 11.54 49 534917 2129 79207293
Enterovesical fistula 24.90 11.54 35 534931 1147 79208275
Tendonitis 24.88 11.54 257 534709 23573 79185849
Foot deformity 24.84 11.54 259 534707 23815 79185607
Atrioventricular block second degree 24.79 11.54 9 534957 7303 79202119
Catheter site erythema 24.77 11.54 3 534963 5237 79204185
Blood phosphorus decreased 24.75 11.54 7 534959 6661 79202761
Behaviour disorder 24.63 11.54 6 534960 6307 79203115
Lacunar infarction 24.57 11.54 5 534961 5952 79203470
Dermatitis bullous 24.42 11.54 36 534930 14209 79195213
Cytomegalovirus viraemia 24.42 11.54 30 534936 12791 79196631
Methaemoglobinaemia 24.35 11.54 4 534962 5553 79203869
Gangrene 24.31 11.54 15 534951 8949 79200473
Embolism 24.30 11.54 35 534931 13947 79195475
Faecaloma 24.27 11.54 25 534941 11539 79197883
Eye infection bacterial 24.26 11.54 20 534946 349 79209073
Vascular device infection 24.19 11.54 20 534946 10256 79199166
Pulmonary thrombosis 24.11 11.54 152 534814 12019 79197403
Self-medication 24.11 11.54 3 534963 5129 79204293
Mean platelet volume decreased 24.09 11.54 56 534910 2734 79206688
Salpingectomy 24.08 11.54 16 534950 197 79209225
Stoma site rash 24.07 11.54 6 534960 0 79209422
Conjunctival haemorrhage 24.03 11.54 5 534961 5860 79203562
Fracture 23.95 11.54 71 534895 21730 79187692
Candida infection 23.89 11.54 154 534812 38060 79171362
Brachiocephalic artery stenosis 23.80 11.54 9 534957 27 79209395
Compartment syndrome 23.80 11.54 3 534963 5079 79204343
Sacroiliitis 23.74 11.54 67 534899 3687 79205735
Mycobacterial infection 23.73 11.54 66 534900 3602 79205820
Sinus node dysfunction 23.65 11.54 11 534955 7690 79201732
Amenorrhoea 23.60 11.54 11 534955 7681 79201741
Mastitis 23.51 11.54 48 534918 2143 79207279
International normalised ratio abnormal 23.46 11.54 5 534961 5763 79203659
Wrist deformity 23.45 11.54 47 534919 2070 79207352
Mycobacterium avium complex infection 23.36 11.54 76 534890 4524 79204898
Urine abnormality 23.36 11.54 13 534953 8206 79201216
Retinal haemorrhage 23.35 11.54 13 534953 8204 79201218
Haemorrhagic diathesis 23.31 11.54 6 534960 6078 79203344
Periumbilical abscess 23.30 11.54 11 534955 65 79209357
Hodgkin's disease stage II 23.09 11.54 8 534958 17 79209405
Supraventricular extrasystoles 23.02 11.54 9 534957 6978 79202444
Tuberculosis of central nervous system 23.00 11.54 22 534944 471 79208951
Libido decreased 22.94 11.54 4 534962 5317 79204105
Brain death 22.93 11.54 5 534961 5672 79203750
Perineal abscess 22.92 11.54 25 534941 628 79208794
Tachyarrhythmia 22.89 11.54 9 534957 6953 79202469
Vaginal infection 22.87 11.54 89 534877 5791 79203631
Immunodeficiency 22.84 11.54 235 534731 21533 79187889
Central nervous system lesion 22.71 11.54 34 534932 13334 79196088
Short stature 22.68 11.54 26 534940 691 79208731
Pulmonary alveolar haemorrhage 22.68 11.54 26 534940 11431 79197991
Transurethral prostatectomy 22.66 11.54 16 534950 219 79209203
Tension headache 22.61 11.54 10 534956 7201 79202221
Nodule 22.61 11.54 245 534721 22749 79186673
Intraventricular haemorrhage 22.61 11.54 3 534963 4884 79204538
Aortic stenosis 22.57 11.54 11 534955 7484 79201938
Hyperhidrosis 22.56 11.54 810 534156 150682 79058740
Cardiac murmur 22.54 11.54 45 534921 15779 79193643
Small intestine operation 22.53 11.54 10 534956 50 79209372
Cholecystitis 22.53 11.54 75 534891 22137 79187285
Splenomegaly 22.50 11.54 68 534898 20686 79188736
Blood albumin decreased 22.49 11.54 85 534881 24158 79185264
Device failure 22.46 11.54 7 534959 6254 79203168
C-reactive protein decreased 22.44 11.54 53 534913 2615 79206807
Obsessive-compulsive disorder 22.42 11.54 6 534960 5921 79203501
Chondropathy 22.33 11.54 51 534915 2461 79206961
Back pain 22.29 11.54 1747 533219 302433 78906989
Vulval abscess 22.26 11.54 27 534939 763 79208659
Product substitution issue 22.23 11.54 66 534900 20190 79189232
Blood urine present 22.23 11.54 71 534895 21226 79188196
Atrial tachycardia 22.20 11.54 10 534956 7123 79202299
BK virus infection 22.17 11.54 16 534950 8788 79200634
Burning sensation 22.14 11.54 269 534697 58363 79151059
Metastases to liver 22.12 11.54 106 534860 28208 79181214
Spondyloarthropathy 22.10 11.54 31 534935 1014 79208408
Abdominal pain upper 22.04 11.54 1252 533714 222567 78986855
Dizziness postural 22.02 11.54 27 534939 11522 79197900
Smear cervix abnormal 22.01 11.54 51 534915 2485 79206937
Blood pressure inadequately controlled 21.99 11.54 7 534959 6170 79203252
Neutrophilia 21.99 11.54 13 534953 7938 79201484
Ocular icterus 21.90 11.54 5 534961 5495 79203927
Accident 21.87 11.54 117 534849 8714 79200708
Non-cardiac chest pain 21.85 11.54 19 534947 9505 79199917
Spinal compression fracture 21.85 11.54 51 534915 16907 79192515
Mean cell volume decreased 21.84 11.54 78 534888 4869 79204553
Blood pressure abnormal 21.83 11.54 52 534914 17117 79192305
Haemothorax 21.78 11.54 5 534961 5473 79203949
Tuberculosis of eye 21.77 11.54 11 534955 77 79209345
Small intestinal obstruction 21.69 11.54 279 534687 26993 79182429
Heavy menstrual bleeding 21.58 11.54 38 534928 13973 79195449
Pneumothorax 21.57 11.54 107 534859 28216 79181206
Meningitis tuberculous 21.50 11.54 33 534933 1172 79208250
Epstein-Barr virus infection 21.49 11.54 168 534798 14248 79195174
Facial paralysis 21.47 11.54 71 534895 21001 79188421
Gastrointestinal mucosa hyperaemia 21.41 11.54 21 534945 464 79208958
Facial pain 21.38 11.54 31 534935 12319 79197103
Laboratory test abnormal 21.34 11.54 106 534860 27942 79181480
Cerebral atrophy 21.23 11.54 14 534952 8061 79201361
Injection site reaction 21.21 11.54 250 534716 54535 79154887
Lower respiratory tract infection viral 21.20 11.54 33 534933 1187 79208235
Enteropathic spondylitis 21.16 11.54 8 534958 24 79209398
Hypoventilation 21.15 11.54 11 534955 7213 79202209
Dental caries 21.13 11.54 29 534937 11791 79197631
Transplant failure 21.12 11.54 3 534963 4638 79204784
Enterococcal infection 21.07 11.54 46 534920 15614 79193808
Oesophageal carcinoma 21.04 11.54 26 534940 11058 79198364
Anaphylactoid reaction 21.03 11.54 82 534884 5340 79204082
Incorrect dose administered by device 20.97 11.54 4 534962 4985 79204437
Colon cancer 20.97 11.54 168 534798 14355 79195067
Multiple-drug resistance 20.91 11.54 17 534949 8791 79200631
Hospitalisation 20.85 11.54 477 534489 93759 79115663
Muscle tightness 20.84 11.54 34 534932 12880 79196542
Testicular seminoma (pure) 20.77 11.54 9 534957 42 79209380
Ischaemic cardiomyopathy 20.70 11.54 13 534953 7682 79201740
Lung transplant 20.63 11.54 3 534963 4558 79204864
Therapy change 20.60 11.54 12 534954 7387 79202035
Upper respiratory tract infection 20.59 11.54 460 534506 90708 79118714
Skin plaque 20.55 11.54 133 534833 10612 79198810
Intra-abdominal haemorrhage 20.50 11.54 3 534963 4537 79204885
Tooth abscess 20.48 11.54 182 534784 16028 79193394
Klebsiella infection 20.48 11.54 47 534919 15673 79193749
Cytomegalovirus infection reactivation 20.47 11.54 17 534949 8699 79200723
Respiratory disorder 20.47 11.54 197 534769 44659 79164763
Lip neoplasm malignant stage unspecified 20.46 11.54 8 534958 27 79209395
Tuberculosis liver 20.40 11.54 10 534956 65 79209357
Vaginal abscess 20.39 11.54 19 534947 393 79209029
Sarcoidosis 20.35 11.54 110 534856 8225 79201197
Pseudopolyposis 20.34 11.54 11 534955 90 79209332
Cough 20.31 11.54 2152 532814 364637 78844785
Areflexia 20.19 11.54 6 534960 5528 79203894
Rectal discharge 20.19 11.54 26 534940 782 79208640
Growth retardation 20.18 11.54 42 534924 1901 79207521
Large intestine operation 20.16 11.54 7 534959 15 79209407
Nervous system disorder 20.14 11.54 102 534864 26754 79182668
Rash morbilliform 20.14 11.54 8 534958 6142 79203280
Blood bicarbonate decreased 20.12 11.54 5 534961 5186 79204236
Anal dilatation 20.06 11.54 5 534961 0 79209422
Motor dysfunction 20.05 11.54 43 534923 14690 79194732
Stomal hernia 20.02 11.54 18 534948 355 79209067
Injection site haematoma 20.02 11.54 4 534962 4823 79204599
Gastrointestinal carcinoma 20.01 11.54 58 534908 3241 79206181
Orbital apex syndrome 19.91 11.54 10 534956 69 79209353
Therapeutic product effect delayed 19.89 11.54 55 534911 2991 79206431
Cerebellar syndrome 19.89 11.54 6 534960 5474 79203948
Hepatic necrosis 19.87 11.54 19 534947 9081 79200341
Intervertebral disc space narrowing 19.80 11.54 39 534927 1696 79207726
Tongue neoplasm malignant stage unspecified 19.79 11.54 30 534936 1054 79208368
Peripheral venous disease 19.78 11.54 178 534788 15731 79193691
Thrombosis in device 19.67 11.54 6 534960 5436 79203986
Application site erythema 19.66 11.54 5 534961 5105 79204317
Hepatitis C 19.61 11.54 31 534935 11894 79197528
Emotional disorder 19.57 11.54 42 534924 14345 79195077
Liver injury 19.56 11.54 508 534458 56106 79153316
Anorectal ulcer 19.51 11.54 9 534957 50 79209372
Non-consummation 19.51 11.54 9 534957 50 79209372
Troponin I increased 19.50 11.54 4 534962 4734 79204688
Takayasu's arteritis 19.47 11.54 6 534960 7 79209415
Hypermobility syndrome 19.46 11.54 21 534945 521 79208901
Laryngeal cancer 19.46 11.54 25 534941 750 79208672
Gastrointestinal cancer metastatic 19.38 11.54 14 534952 199 79209223
Myositis 19.25 11.54 65 534901 19103 79190319
Bladder repair 19.23 11.54 9 534957 52 79209370
Prescribed overdose 19.16 11.54 359 534607 37524 79171898
Respiratory alkalosis 19.12 11.54 3 534963 4308 79205114
Haemorrhage 19.11 11.54 465 534501 90653 79118769
Genital haemorrhage 19.11 11.54 9 534957 6246 79203176
Cystitis haemorrhagic 19.06 11.54 20 534946 9152 79200270
Groin abscess 19.02 11.54 36 534930 1519 79207903
High density lipoprotein decreased 19.01 11.54 4 534962 4651 79204771
Obstruction 18.93 11.54 71 534895 4539 79204883
Root canal infection 18.91 11.54 18 534948 383 79209039
Diabetic neuropathy 18.90 11.54 9 534957 6207 79203215
Carcinoma in situ of skin 18.71 11.54 13 534953 173 79209249
Ischaemia 18.66 11.54 16 534950 8059 79201363
Intercepted product prescribing error 18.64 11.54 16 534950 296 79209126
Middle insomnia 18.63 11.54 51 534915 16018 79193404
Osteopenia 18.63 11.54 62 534904 18302 79191120
Thoracic vertebral fracture 18.62 11.54 6 534960 5247 79204175
Herpes ophthalmic 18.58 11.54 35 534931 1472 79207950
Hepatitis fulminant 18.54 11.54 13 534953 7249 79202173
Skin abrasion 18.54 11.54 39 534927 13417 79196005
Malignant melanoma stage I 18.53 11.54 12 534954 141 79209281
Epstein-Barr virus associated lymphoproliferative disorder 18.52 11.54 59 534907 3473 79205949
Lewis-Sumner syndrome 18.52 11.54 8 534958 37 79209385
Bone density decreased 18.52 11.54 153 534813 13194 79196228
Arthritis bacterial 18.49 11.54 115 534851 9051 79200371
Stress at work 18.44 11.54 30 534936 1121 79208301
Immunosuppression 18.43 11.54 148 534818 12655 79196767
Nephrotic syndrome 18.42 11.54 29 534937 11145 79198277
Pelvic abscess 18.41 11.54 43 534923 2106 79207316
Neoplasm prostate 18.40 11.54 13 534953 178 79209244
Dermatitis acneiform 18.39 11.54 24 534942 9969 79199453
Intervertebral disc degeneration 18.38 11.54 50 534916 15735 79193687
Hepatocellular carcinoma 18.38 11.54 20 534946 9001 79200421
Product physical issue 18.37 11.54 3 534963 4182 79205240
Lung infiltration 18.36 11.54 85 534881 22827 79186595
Post-traumatic stress disorder 18.35 11.54 5 534961 4876 79204546
Scleroderma 18.32 11.54 7 534959 5503 79203919
Craniocerebral injury 18.30 11.54 6 534960 5190 79204232
Lip ulceration 18.28 11.54 45 534921 2280 79207142
Renal cell carcinoma 18.27 11.54 90 534876 6488 79202934
Ostomy bag placement 18.25 11.54 6 534960 10 79209412
Proctitis ulcerative 18.24 11.54 16 534950 305 79209117
Refusal of treatment by patient 18.24 11.54 20 534946 8971 79200451
Cytomegalovirus chorioretinitis 18.21 11.54 7 534959 5483 79203939
Anorectal stenosis 18.19 11.54 8 534958 39 79209383
Disease susceptibility 18.16 11.54 16 534950 307 79209115
Sensory disturbance 18.13 11.54 47 534919 15030 79194392
Axial spondyloarthritis 18.12 11.54 21 534945 565 79208857
Neuroendocrine carcinoma of the skin 18.11 11.54 32 534934 1280 79208142
Renal neoplasm 18.11 11.54 41 534925 1967 79207455
Congestive cardiomyopathy 18.10 11.54 32 534934 11748 79197674
Retroperitoneal haemorrhage 18.10 11.54 7 534959 5463 79203959
Anal skin tags 18.05 11.54 19 534947 458 79208964
Epstein Barr virus positive mucocutaneous ulcer 18.00 11.54 25 534941 810 79208612
Omphalitis 17.97 11.54 10 534956 87 79209335
Small intestine carcinoma 17.97 11.54 28 534938 1008 79208414
Joint lock 17.95 11.54 55 534911 3170 79206252
Bronchial secretion retention 17.88 11.54 3 534963 4101 79205321
Blood sodium increased 17.88 11.54 5 534961 4793 79204629
Dermatitis contact 17.85 11.54 29 534937 11004 79198418
Hernia 17.82 11.54 184 534782 16875 79192547
Obesity 17.81 11.54 333 534633 34792 79174630
Blood thyroid stimulating hormone decreased 17.81 11.54 8 534958 5708 79203714
Enterocolonic fistula 17.77 11.54 12 534954 152 79209270
Prescription drug used without a prescription 17.77 11.54 3 534963 4082 79205340
Cytomegalovirus mononucleosis 17.73 11.54 5 534961 3 79209419
Diabetic eye disease 17.71 11.54 12 534954 153 79209269
Abnormal loss of weight 17.70 11.54 18 534948 8358 79201064
Pneumocystis jirovecii infection 17.67 11.54 51 534915 2843 79206579
Dermatitis atopic 17.65 11.54 25 534941 10031 79199391
Parainfluenzae virus infection 17.63 11.54 8 534958 5674 79203748
Visceral leishmaniasis 17.62 11.54 29 534937 1094 79208328
Diverticulum intestinal 17.61 11.54 19 534947 8586 79200836
Overgrowth bacterial 17.52 11.54 13 534953 193 79209229
Gastric perforation 17.48 11.54 3 534963 4034 79205388
Psychiatric symptom 17.43 11.54 13 534953 7022 79202400
Aortic valve incompetence 17.42 11.54 23 534943 9507 79199915
Blood pH decreased 17.39 11.54 5 534961 4706 79204716
Abscess limb 17.33 11.54 93 534873 6934 79202488
Pneumonia viral 17.30 11.54 113 534853 9045 79200377
Adjustment disorder 17.26 11.54 3 534963 3997 79205425
Fistulotomy 17.24 11.54 6 534960 13 79209409
Anaemia macrocytic 17.18 11.54 8 534958 5589 79203833
Infrequent bowel movements 17.09 11.54 36 534930 1643 79207779
Ecchymosis 17.08 11.54 49 534917 15157 79194265
Procedural complication 17.05 11.54 17 534949 7966 79201456
Feeling jittery 17.05 11.54 38 534928 12803 79196619
Phototherapy 17.00 11.54 7 534959 28 79209394
Ileocolectomy 17.00 11.54 7 534959 28 79209394
Eye symptom 16.97 11.54 10 534956 98 79209324
Arterial occlusive disease 16.95 11.54 19 534947 8437 79200985
Spinal fracture 16.94 11.54 63 534903 17991 79191431
Cortical dysplasia 16.94 11.54 6 534960 14 79209408
Autonomic nervous system imbalance 16.93 11.54 5 534961 4625 79204797
Upper-airway cough syndrome 16.87 11.54 33 534933 11660 79197762
Clostridium difficile colitis 16.84 11.54 137 534829 32146 79177276
Blood culture positive 16.83 11.54 19 534947 8410 79201012
Skin hypertrophy 16.82 11.54 6 534960 4922 79204500
Eczema infected 16.81 11.54 9 534957 72 79209350
Skin tightness 16.78 11.54 8 534958 5514 79203908
Gastrointestinal infection 16.78 11.54 133 534833 11328 79198094
Nephrogenic anaemia 16.68 11.54 3 534963 3899 79205523
Anti-saccharomyces cerevisiae antibody 16.65 11.54 6 534960 15 79209407
Salmonella sepsis 16.65 11.54 17 534949 395 79209027
Bone tuberculosis 16.63 11.54 20 534946 560 79208862
Hypercholesterolaemia 16.61 11.54 232 534734 22863 79186559
Drainage 16.59 11.54 11 534955 135 79209287
Oesophageal varices haemorrhage 16.58 11.54 4 534962 4232 79205190
Gastrointestinal fistula 16.54 11.54 23 534943 746 79208676
Portal hypertension 16.53 11.54 14 534952 7094 79202328
Peritonitis 16.51 11.54 115 534851 27921 79181501
Inflammatory pain 16.50 11.54 27 534939 1014 79208408
Gastrointestinal toxicity 16.49 11.54 18 534948 8091 79201331
Congestive hepatopathy 16.46 11.54 5 534961 4542 79204880
Neurogenic bladder 16.44 11.54 4 534962 4208 79205214
Fluid intake reduced 16.40 11.54 11 534955 6277 79203145
Blood iron decreased 16.38 11.54 167 534799 15267 79194155
Nerve block 16.35 11.54 22 534944 691 79208731
Bacteraemia 16.35 11.54 141 534825 32683 79176739
Intracranial pressure increased 16.35 11.54 19 534947 8303 79201119
Cardiopulmonary failure 16.30 11.54 13 534953 6788 79202634
Deafness 16.29 11.54 79 534887 20958 79188464
Investigation abnormal 16.26 11.54 40 534926 2026 79207396
Episcleritis 16.23 11.54 27 534939 1028 79208394
Urine analysis abnormal 16.22 11.54 12 534954 6508 79202914
Chronic graft versus host disease 16.21 11.54 13 534953 6768 79202654
Mass 16.19 11.54 184 534782 17288 79192134
Exploratory operation 16.15 11.54 5 534961 6 79209416
Peripheral ischaemia 16.11 11.54 24 534942 9433 79199989
Cutaneous tuberculosis 16.10 11.54 13 534953 220 79209202
Oligoarthritis 16.09 11.54 22 534944 702 79208720
Keratomileusis 16.04 11.54 4 534962 0 79209422
Anal dilation procedure 16.04 11.54 4 534962 0 79209422
Systolic dysfunction 16.04 11.54 3 534963 3792 79205630
Anger 16.03 11.54 60 534906 17102 79192320
Small intestine adenocarcinoma 16.01 11.54 12 534954 181 79209241
Furuncle 16.01 11.54 96 534870 7458 79201964
Injection site nodule 15.96 11.54 3 534963 3777 79205645
Anaplastic large-cell lymphoma 15.96 11.54 13 534953 223 79209199
Genital cyst 15.95 11.54 8 534958 55 79209367
C-reactive protein 15.94 11.54 71 534895 4908 79204514
Haemolytic uraemic syndrome 15.91 11.54 5 534961 4444 79204978
Pseudomonal sepsis 15.84 11.54 11 534955 6163 79203259
Culture urine positive 15.84 11.54 5 534961 4430 79204992
Neck mass 15.80 11.54 65 534901 4339 79205083
Eye infection toxoplasmal 15.77 11.54 19 534947 533 79208889
Unevaluable specimen 15.73 11.54 5 534961 7 79209415
Electrocardiogram T wave abnormal 15.71 11.54 3 534963 3735 79205687
Leukoencephalopathy 15.69 11.54 18 534948 7911 79201511
Sickle cell anaemia with crisis 15.66 11.54 18 534948 7904 79201518
Presyncope 15.64 11.54 188 534778 40866 79168556
Dysplasia 15.63 11.54 31 534935 1355 79208067
Chronic disease 15.61 11.54 11 534955 150 79209272
Morning sickness 15.58 11.54 19 534947 540 79208882
Palmoplantar keratoderma 15.58 11.54 3 534963 3713 79205709
Shoulder arthroplasty 15.58 11.54 53 534913 3229 79206193
Renal function test abnormal 15.56 11.54 7 534959 4991 79204431
Hyperaesthesia 15.55 11.54 37 534929 12185 79197237
Cytomegalovirus enteritis 15.53 11.54 23 534943 791 79208631
Lumbar spinal stenosis 15.53 11.54 8 534958 5274 79204148
Carotid artery occlusion 15.53 11.54 17 534949 7630 79201792
Thrombotic thrombocytopenic purpura 15.52 11.54 12 534954 6364 79203058
Tonsil cancer 15.50 11.54 28 534938 1140 79208282
Product substitution 15.47 11.54 9 534957 86 79209336
Internal haemorrhage 15.46 11.54 22 534944 8811 79200611
Lymphocyte percentage decreased 15.45 11.54 7 534959 4969 79204453
Logorrhoea 15.45 11.54 5 534961 4360 79205062
Pruritus allergic 15.43 11.54 31 534935 1368 79208054
Haemarthrosis 15.38 11.54 10 534956 5802 79203620
Tongue oedema 15.38 11.54 15 534951 7102 79202320
Colonoscopy abnormal 15.37 11.54 12 534954 193 79209229
Joint tuberculosis 15.37 11.54 11 534955 154 79209268
Intestinal malrotation 15.33 11.54 5 534961 8 79209414
Diverticulum intestinal haemorrhagic 15.28 11.54 4 534962 4007 79205415
Crohn's disease 15.28 11.54 39 534927 2021 79207401
Septic pulmonary embolism 15.27 11.54 10 534956 120 79209302
Cryptitis 15.25 11.54 14 534952 284 79209138
Disease complication 15.24 11.54 7 534959 4930 79204492
Postoperative abscess 15.18 11.54 22 534944 742 79208680
Clinically isolated syndrome 15.16 11.54 7 534959 39 79209383
Nasal congestion 15.11 11.54 643 534323 75909 79133513
Sputum increased 15.10 11.54 6 534960 4607 79204815
Postoperative wound infection 15.10 11.54 143 534823 12818 79196604
Cervix carcinoma stage 0 15.08 11.54 13 534953 242 79209180
Peripheral vascular disorder 15.07 11.54 19 534947 8011 79201411
Intracardiac thrombus 15.05 11.54 5 534961 4288 79205134
Histone antibody positive 15.04 11.54 9 534957 91 79209331
Polychondritis 15.02 11.54 19 534947 561 79208861
Nephritis bacterial 15.02 11.54 7 534959 40 79209382
Renal tubular acidosis 14.98 11.54 3 534963 3611 79205811
Stillbirth 14.96 11.54 4 534962 3951 79205471
Palmoplantar pustulosis 14.94 11.54 19 534947 564 79208858
Lumbar vertebral fracture 14.94 11.54 15 534951 7007 79202415
Varices oesophageal 14.94 11.54 11 534955 5980 79203442
Post procedural haemorrhage 14.93 11.54 45 534921 13699 79195723
Product availability issue 14.92 11.54 4 534962 3943 79205479
Skin atrophy 14.92 11.54 10 534956 5708 79203714
Benign prostatic hyperplasia 14.90 11.54 35 534931 11577 79197845
Multifocal motor neuropathy 14.88 11.54 7 534959 41 79209381
Respiratory tract congestion 14.84 11.54 76 534890 19878 79189544
Vitamin B12 deficiency 14.81 11.54 16 534950 7225 79202197
Spondylitis 14.80 11.54 67 534899 4664 79204758
Renal cyst 14.76 11.54 50 534916 14682 79194740
Tonsillitis streptococcal 14.73 11.54 11 534955 165 79209257
Infected cyst 14.72 11.54 29 534937 1261 79208161
Jejunal stenosis 14.71 11.54 9 534957 95 79209327
Subacute cutaneous lupus erythematosus 14.67 11.54 3 534963 3558 79205864
Arthritis salmonella 14.63 11.54 5 534961 10 79209412
Rectal cancer metastatic 14.62 11.54 17 534949 459 79208963
Scleritis 14.62 11.54 63 534903 4293 79205129
Protein total decreased 14.61 11.54 24 534942 9068 79200354
Abdominal operation 14.59 11.54 19 534947 578 79208844
Oral discomfort 14.56 11.54 27 534939 9733 79199689
Diffuse large B-cell lymphoma stage II 14.56 11.54 9 534957 97 79209325
Secondary amyloidosis 14.53 11.54 12 534954 210 79209212
Product residue present 14.52 11.54 3 534963 3533 79205889
Pericardial haemorrhage 14.47 11.54 6 534960 4489 79204933
Adenocarcinoma 14.45 11.54 58 534908 3828 79205594
Hypersomnia 14.45 11.54 93 534873 22993 79186429
Breast abscess 14.43 11.54 31 534935 1435 79207987
Prostatic specific antigen increased 14.40 11.54 30 534936 10356 79199066
Bacterial vulvovaginitis 14.39 11.54 19 534947 586 79208836
Focal dyscognitive seizures 14.38 11.54 3 534963 3509 79205913
Photopsia 14.37 11.54 9 534957 5327 79204095
Small intestinal haemorrhage 14.33 11.54 5 534961 4158 79205264
Adhesiolysis 14.31 11.54 5 534961 11 79209411
Inadequate diet 14.31 11.54 13 534953 260 79209162
Spinal cord compression 14.30 11.54 13 534953 6364 79203058
Limb operation 14.27 11.54 53 534913 3373 79206049
Bradyarrhythmia 14.23 11.54 5 534961 4141 79205281
Oesophageal fibrosis 14.19 11.54 11 534955 175 79209247
Pallor 14.18 11.54 438 534528 49624 79159798
Dysphoria 14.17 11.54 7 534959 4727 79204695
Snoring 14.17 11.54 10 534956 5556 79203866
Aortic valve stenosis 14.16 11.54 9 534957 5285 79204137
Cardiac pacemaker insertion 14.12 11.54 11 534955 5811 79203611
Pregnancy 14.12 11.54 256 534710 26595 79182827
Product administered to patient of inappropriate age 14.10 11.54 10 534956 5543 79203879
Paraparesis 14.10 11.54 4 534962 3799 79205623
Papilloma viral infection 14.10 11.54 34 534932 1700 79207722
White blood cells urine positive 14.08 11.54 12 534954 6063 79203359
Foreign body in eye 14.07 11.54 13 534953 266 79209156
Oesophageal spasm 14.05 11.54 3 534963 3453 79205969
Procedural haemorrhage 14.03 11.54 7 534959 4699 79204723
Female genital tract fistula 14.01 11.54 78 534888 5897 79203525
Skin hyperpigmentation 14 11.54 17 534949 7286 79202136
Impetigo 13.99 11.54 38 534928 2045 79207377
Drug resistance 13.99 11.54 199 534767 42014 79167408
Communication disorder 13.93 11.54 5 534961 4085 79205337
Infusion site pain 13.92 11.54 151 534815 14025 79195397
Staphylococcal skin infection 13.90 11.54 32 534934 1552 79207870
Lupus pleurisy 13.83 11.54 4 534962 3 79209419
Drain removal 13.83 11.54 4 534962 3 79209419
Anal neoplasm 13.83 11.54 4 534962 3 79209419
Thyroid cancer 13.81 11.54 74 534892 5514 79203908
Vitreous floaters 13.79 11.54 17 534949 7239 79202183
Nasal discomfort 13.76 11.54 10 534956 5473 79203949
Circumcision 13.74 11.54 5 534961 13 79209409
Drain site complication 13.74 11.54 5 534961 13 79209409
Urostomy 13.74 11.54 5 534961 13 79209409
Abdominal distension 13.72 11.54 659 534307 118991 79090431
Tonsillectomy 13.72 11.54 19 534947 614 79208808
Pharyngeal neoplasm 13.68 11.54 6 534960 29 79209393
Alcoholism 13.65 11.54 4 534962 3719 79205703
Rhonchi 13.63 11.54 5 534961 4031 79205391
Gastrointestinal obstruction 13.62 11.54 34 534932 1738 79207684
Metastases to lymph nodes 13.61 11.54 31 534935 10366 79199056
Dysgraphia 13.61 11.54 5 534961 4027 79205395
Vascular stent thrombosis 13.58 11.54 4 534962 3706 79205716
Oral candidiasis 13.57 11.54 130 534836 29498 79179924
Dissociation 13.55 11.54 5 534961 4016 79205406
Dilatation atrial 13.54 11.54 4 534962 3700 79205722
Electroencephalogram abnormal 13.52 11.54 10 534956 5424 79203998
Heart rate abnormal 13.50 11.54 78 534888 5979 79203443
Electrocardiogram ST segment depression 13.46 11.54 8 534958 4870 79204552
Ear neoplasm 13.44 11.54 11 534955 190 79209232
Complications of bone marrow transplant 13.42 11.54 19 534947 627 79208795
Anal ulcer 13.40 11.54 29 534937 1349 79208073
Live birth 13.36 11.54 188 534778 18556 79190866
Product label confusion 13.35 11.54 32 534934 1594 79207828
Rotator cuff syndrome 13.35 11.54 49 534917 14046 79195376
Pneumomediastinum 13.34 11.54 4 534962 3663 79205759
Eosinophilic granulomatosis with polyangiitis 13.30 11.54 4 534962 3656 79205766
Back disorder 13.24 11.54 37 534929 11541 79197881
Enteropathy-associated T-cell lymphoma 13.23 11.54 5 534961 15 79209407
Cerebellar infarction 13.22 11.54 4 534962 3643 79205779
Electrocardiogram T wave inversion 13.22 11.54 10 534956 5362 79204060
Galactorrhoea 13.22 11.54 4 534962 3642 79205780
Benign neoplasm 13.16 11.54 25 534941 1058 79208364
Mean cell haemoglobin decreased 13.13 11.54 79 534887 6145 79203277
Stoma site abscess 13.13 11.54 12 534954 242 79209180
Double stranded DNA antibody positive 13.11 11.54 16 534950 455 79208967
Anorectal swelling 13.11 11.54 8 534958 84 79209338
Retinal artery occlusion 13.11 11.54 3 534963 3291 79206131
Skin induration 13.09 11.54 7 534959 4518 79204904
Extranodal marginal zone B-cell lymphoma (MALT type) 13.08 11.54 18 534948 578 79208844
Food poisoning 13.07 11.54 65 534901 4704 79204718
Angiopathy 13.04 11.54 17 534949 7065 79202357
Capillary leak syndrome 13.03 11.54 5 534961 3920 79205502
Acute pulmonary histoplasmosis 12.97 11.54 12 534954 246 79209176
Impaired gastric emptying 12.96 11.54 116 534850 10237 79199185
Lymphadenitis bacterial 12.96 11.54 8 534958 86 79209336
Normocytic anaemia 12.93 11.54 6 534960 4201 79205221
Hypertensive heart disease 12.93 11.54 6 534960 4200 79205222
Oophorectomy bilateral 12.91 11.54 6 534960 34 79209388
Rash papular 12.86 11.54 90 534876 21826 79187596
Renal colic 12.85 11.54 45 534921 2782 79206640
Cellulitis 12.84 11.54 599 534367 108461 79100961
Suicidal behaviour 12.84 11.54 3 534963 3244 79206178
Cutaneous nocardiosis 12.84 11.54 11 534955 203 79209219
Eye pruritus 12.80 11.54 83 534883 20487 79188935
Coronavirus infection 12.80 11.54 19 534947 7478 79201944
Application site pain 12.79 11.54 8 534958 4739 79204683
Urine ketone body present 12.76 11.54 4 534962 3561 79205861
Endodontic procedure 12.76 11.54 44 534922 2699 79206723
Bowen's disease 12.76 11.54 9 534957 123 79209299
Elbow operation 12.73 11.54 14 534952 355 79209067
Faecal calprotectin 12.72 11.54 8 534958 89 79209333
Stoma complication 12.65 11.54 21 534945 798 79208624
Tonsillitis bacterial 12.65 11.54 10 534956 164 79209258
Language disorder 12.65 11.54 3 534963 3211 79206211
HIV test positive 12.63 11.54 9 534957 125 79209297
Bile acid malabsorption 12.61 11.54 11 534955 208 79209214
Kidney fibrosis 12.60 11.54 4 534962 3531 79205891
Intestinal anastomosis complication 12.59 11.54 13 534953 306 79209116
Hair texture abnormal 12.59 11.54 4 534962 3530 79205892
Cutaneous lymphoma 12.58 11.54 12 534954 256 79209166
Vulval disorder 12.58 11.54 18 534948 600 79208822
Body height decreased 12.57 11.54 24 534942 8556 79200866
Pharyngeal cyst 12.55 11.54 5 534961 18 79209404
Plasmacytoma 12.46 11.54 7 534959 4396 79205026
Chlamydial infection 12.45 11.54 17 534949 542 79208880
Enuresis 12.43 11.54 3 534963 3173 79206249
Gliomatosis cerebri 12.42 11.54 4 534962 6 79209416
Sensory loss 12.41 11.54 45 534921 12946 79196476
Eructation 12.37 11.54 35 534931 10874 79198548
Discharge 12.35 11.54 29 534937 1425 79207997
Cyclic neutropenia 12.34 11.54 5 534961 19 79209403
Dysphemia 12.31 11.54 4 534962 3480 79205942
Nerve injury 12.30 11.54 28 534938 9364 79200058
Lung opacity 12.27 11.54 10 534956 5164 79204258
Concomitant disease progression 12.25 11.54 4 534962 3469 79205953
Cachexia 12.24 11.54 36 534930 11047 79198375
Myelopathy 12.22 11.54 8 534958 4625 79204797
Vesical fistula 12.22 11.54 9 534957 132 79209290
Large intestine anastomosis 12.21 11.54 8 534958 96 79209326
Short-bowel syndrome 12.21 11.54 17 534949 552 79208870
Stenotrophomonas infection 12.20 11.54 5 534961 3768 79205654
Serum sickness-like reaction 12.20 11.54 18 534948 617 79208805
Paronychia 12.19 11.54 21 534945 7787 79201635
Vaginal ulceration 12.17 11.54 12 534954 267 79209155
Vaginal haematoma 12.17 11.54 9 534957 133 79209289
Hyperthermia 12.15 11.54 71 534895 17966 79191456
International normalised ratio fluctuation 12.15 11.54 4 534962 3450 79205972
Catheter site pain 12.10 11.54 11 534955 5385 79204037
Oral pustule 12.10 11.54 12 534954 269 79209153
Oropharyngeal discomfort 12.09 11.54 86 534880 7080 79202342
Scarlet fever 12.05 11.54 9 534957 135 79209287
Heat oedema 12.05 11.54 4 534962 7 79209415
Lung cancer metastatic 12.04 11.54 53 534913 3646 79205776
Intermenstrual bleeding 12.04 11.54 13 534953 5871 79203551
Mastoidectomy 12.03 11.54 3 534963 0 79209422
Endometrial neoplasm 12.03 11.54 3 534963 0 79209422
Rectal injury 12.03 11.54 3 534963 0 79209422
Unhealthy diet 12.03 11.54 3 534963 0 79209422
Pericarditis lupus 12.03 11.54 3 534963 0 79209422
Pilonidal sinus repair 12.03 11.54 3 534963 0 79209422
Spinal fusion surgery 12.03 11.54 68 534898 5170 79204252
Rotavirus test positive 12.03 11.54 3 534963 0 79209422
Jejunectomy 12.03 11.54 3 534963 0 79209422
Otitis externa bacterial 12.03 11.54 3 534963 0 79209422
Herpes pharyngitis 12.03 11.54 3 534963 0 79209422
Foreign body in skin or subcutaneous tissue 12.03 11.54 3 534963 0 79209422
Platelet count abnormal 12.03 11.54 9 534957 4853 79204569
Pseudomembranous colitis 12.00 11.54 11 534955 5363 79204059
Dyspnoea at rest 11.99 11.54 19 534947 7283 79202139
Pharyngitis bacterial 11.99 11.54 12 534954 272 79209150
Glossitis 11.97 11.54 5 534961 3725 79205697
Oral pain 11.96 11.54 146 534820 31652 79177770
Sneezing 11.96 11.54 80 534886 19603 79189819
Alcohol abuse 11.94 11.54 11 534955 5352 79204070
Haemoglobin abnormal 11.92 11.54 18 534948 7036 79202386
Duodenitis 11.92 11.54 22 534944 7945 79201477
Blood immunoglobulin G decreased 11.90 11.54 4 534962 3405 79206017
Bladder transitional cell carcinoma 11.89 11.54 42 534924 2608 79206814
Alcohol use 11.88 11.54 9 534957 4822 79204600
Sluggishness 11.87 11.54 16 534950 6556 79202866
Urticarial vasculitis 11.87 11.54 17 534949 567 79208855
Rhinovirus infection 11.86 11.54 22 534944 7931 79201491
Alcohol poisoning 11.83 11.54 9 534957 4812 79204610
Eosinophil count decreased 11.82 11.54 4 534962 3392 79206030
Catheter site infection 11.82 11.54 17 534949 6778 79202644
Visual field defect 11.82 11.54 27 534939 9018 79200404
Prostate infection 11.80 11.54 18 534948 636 79208786
Salpingo-oophorectomy 11.77 11.54 5 534961 22 79209400
Bronchopulmonary aspergillosis allergic 11.77 11.54 3 534963 3058 79206364
Thyroidectomy 11.76 11.54 22 534944 920 79208502
Cardiovascular disorder 11.75 11.54 178 534788 17847 79191575
Laryngeal disorder 11.75 11.54 24 534942 1072 79208350
Nasopharyngeal cancer 11.74 11.54 10 534956 183 79209239
Paralysis 11.71 11.54 47 534919 13130 79196292
Food intolerance 11.67 11.54 54 534912 3794 79205628
Odynophagia 11.66 11.54 38 534928 11289 79198133
Meningitis coccidioides 11.64 11.54 6 534960 44 79209378
Body temperature increased 11.63 11.54 385 534581 44035 79165387
Urine odour abnormal 11.61 11.54 15 534951 6258 79203164
Serum ferritin increased 11.61 11.54 31 534935 9816 79199606
Cerebral disorder 11.59 11.54 12 534954 5526 79203896
Major depression 11.58 11.54 27 534939 8953 79200469
Increased tendency to bruise 11.55 11.54 34 534932 10430 79198992
Febrile infection 11.55 11.54 4 534962 3342 79206080

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AB02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Tumor necrosis factor alpha (TNF-alpha) inhibitors
FDA MoA N0000175451 Tumor Necrosis Factor Receptor Blocking Activity
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D000079424 Tumor Necrosis Factor Inhibitors
FDA EPC N0000175610 Tumor Necrosis Factor Blocker

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Ulcerative colitis indication 64766004 DOID:8577
Rheumatoid arthritis indication 69896004 DOID:7148
Plaque psoriasis indication 200965009
Pustular psoriasis indication 200973000
Erythrodermic psoriasis indication 200977004
Behcet's disease indication 310701003 DOID:13241
Adenosine deaminase deficiency 2 off-label use 987840791000119102




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tumor necrosis factor Cytokine ANTIBODY BINDING UNKNOWN DRUG LABEL

External reference:

IDSource
D02598 KEGG_DRUG
4021126 VUID
N0000148580 NUI
4021126 VANDF
4036143 VANDF
CHEMBL1201581 ChEMBL_ID
5004 IUPHAR_LIGAND_ID
DB00065 DRUGBANK_ID
1790539 RXNORM
11846 MMSL
230325 MMSL
33395 MMSL
33397 MMSL
353325 MMSL
7489 MMSL
d04342 MMSL
007640 NDDF
016773 NDDF
017837 NDDF
108675009 SNOMEDCT_US
386891004 SNOMEDCT_US
D000069285 MESH_DESCRIPTOR_UI
C0666743 UMLSCUI
7602 INN_ID
B72HH48FLU UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Renflexis HUMAN PRESCRIPTION DRUG LABEL 1 0006-4305 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 29 sections
Renflexis HUMAN PRESCRIPTION DRUG LABEL 1 0006-4305 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 29 sections
INFLECTRA HUMAN PRESCRIPTION DRUG LABEL 1 0069-0809 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 33 sections
INFLECTRA HUMAN PRESCRIPTION DRUG LABEL 1 0069-0809 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 33 sections
INFLECTRA HUMAN PRESCRIPTION DRUG LABEL 1 0069-0809 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 33 sections
AVSOLA HUMAN PRESCRIPTION DRUG LABEL 1 55513-670 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 33 sections
AVSOLA HUMAN PRESCRIPTION DRUG LABEL 1 55513-670 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 33 sections
AVSOLA HUMAN PRESCRIPTION DRUG LABEL 1 55513-670 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 33 sections
REMICADE HUMAN PRESCRIPTION DRUG LABEL 1 57894-030 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 31 sections
REMICADE HUMAN PRESCRIPTION DRUG LABEL 1 57894-030 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 31 sections
INFLIXIMAB HUMAN PRESCRIPTION DRUG LABEL 1 57894-160 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 32 sections
Renflexis HUMAN PRESCRIPTION DRUG LABEL 1 78206-162 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 30 sections