infliximab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
chimeric origin 4974 170277-31-3

Description:

MoleculeDescription

Synonyms:

  • INFLIXIMAB-QBTX
  • inflectra
  • infliximab
  • remicade
  • infliximab-dyyb
Infliximab products neutralize the biological activity of TNF-alpha by binding with high affinity to the soluble and transmembrane forms of TNF-alpha and inhibit binding of TNF-alpha with its receptors. Infliximab products do not neutralize TNF-beta (lymphotoxin-alpha), a related cytokine that utilizes the same receptors as TNF-alpha. Biological activities attributed to TNF-alpha include: induction of pro-inflammatory cytokines such as interleukins (IL) 1 and 6, enhancement of leukocyte migration by increasing endothelial layer permeability and expression of adhesion molecules by endothelial cells and leukocytes, activation of neutrophil and eosinophil functional activity, induction of acute phase reactants and other liver proteins, as well as tissue degrading enzymes produced by synoviocytes and/or chondrocytes. Cells expressing transmembrane TNF-alpha bound by infliximab products can be lysed in vitro or in vivo. Infliximab products inhibit the functional activity of TNF-alpha in a wide variety of in vitro bioassays utilizing human fibroblasts, endothelial cells, neutrophils, B and T-lymphocytes and epithelial cells. The relationship of these biological response markers to the mechanism(s) by which infliximab products exert their clinical effects is unknown. Anti-TNF-alpha antibodies reduce disease activity in the cotton-top tamarin colitis model, and decrease synovitis and joint erosions in a murine model of collagen-induced arthritis. Infliximab products prevent disease in transgenic mice that develop polyarthritis as a result of constitutive expression of human TNF-alpha, and when administered after disease onset, allow eroded joints to heal.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3.75 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Aug. 24, 1998 FDA CENTOCOR INC
Aug. 13, 1999 EMA
Jan. 17, 2002 PMDA Tanabe Seiyaku

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Infusion related reaction 4761.80 11.46 10623 744458 406157 89467209
Off label use 3224.75 11.46 17817 737264 1084435 88788931
Intentional product use issue 2791.92 11.46 5809 749272 211083 89662283
Product use issue 2455.46 11.46 7159 747922 322760 89550606
Condition aggravated 2153.73 11.46 10232 744849 585313 89288053
Systemic lupus erythematosus 2047.65 11.46 7147 747934 354749 89518617
Toxicity to various agents 1980.82 11.46 101 754980 287745 89585621
Contraindicated product administered 1972.27 11.46 6506 748575 313633 89559733
Drug ineffective 1958.85 11.46 18808 736273 1365490 88507876
Drug intolerance 1692.44 11.46 7795 747286 439796 89433570
Acute kidney injury 1687.00 11.46 314 754767 320073 89553293
Pemphigus 1681.21 11.46 6259 748822 320605 89552761
Treatment failure 1620.99 11.46 5889 749192 298039 89575327
Synovitis 1588.45 11.46 6184 748897 323568 89549798
Drug interaction 1574.23 11.46 218 754863 276235 89597131
Death 1566.50 11.46 932 754149 455619 89417747
Glossodynia 1523.45 11.46 6002 749079 315777 89557589
Arthropathy 1479.21 11.46 6506 748575 359736 89513630
Alopecia 1414.29 11.46 7970 747111 487101 89386265
Inappropriate schedule of product administration 1371.96 11.46 3513 751568 146420 89726946
Hand deformity 1328.90 11.46 5436 749645 290926 89582440
Therapeutic product effect decreased 1221.91 11.46 5063 750018 272508 89600858
Lupus-like syndrome 1173.01 11.46 1724 753357 47122 89826244
Neutropenia 1126.04 11.46 248 754833 224656 89648710
Completed suicide 1099.37 11.46 22 755059 145036 89728330
Febrile neutropenia 1053.67 11.46 67 755014 158282 89715084
Wound 1048.85 11.46 5147 749934 297833 89575533
Abdominal discomfort 1027.86 11.46 7150 747931 470178 89403188
Fall 1014.48 11.46 1528 753553 480282 89393084
Anaemia 998.49 11.46 882 754199 351920 89521446
Anti-cyclic citrullinated peptide antibody positive 947.00 11.46 4192 750889 232241 89641125
Joint swelling 932.84 11.46 7275 747806 496025 89377341
Drug specific antibody present 883.95 11.46 559 754522 4955 89868411
Pericarditis 868.95 11.46 4496 750585 265655 89607711
Drug level below therapeutic 849.50 11.46 556 754525 5258 89868108
Swelling 825.63 11.46 6146 748935 412912 89460454
Hepatic enzyme increased 822.40 11.46 5482 749599 355254 89518112
Intestinal resection 817.03 11.46 426 754655 2501 89870865
Injection site pain 804.40 11.46 225 754856 173474 89699892
Product dose omission issue 763.33 11.46 782 754299 290905 89582461
Hyponatraemia 751.04 11.46 109 754972 133429 89739937
Hypotension 746.12 11.46 970 754111 324427 89548939
Fistula 736.82 11.46 689 754392 11400 89861966
Disease progression 732.44 11.46 199 754882 156416 89716950
Malignant neoplasm progression 714.55 11.46 44 755037 106826 89766540
Discomfort 711.51 11.46 4309 750772 270026 89603340
Intentional overdose 703.95 11.46 16 755065 93818 89779548
Rheumatoid factor positive 701.02 11.46 3062 752019 168588 89704778
Somnolence 700.44 11.46 438 754643 208646 89664720
White blood cell count decreased 657.62 11.46 284 754797 166825 89706541
Arthralgia 647.17 11.46 9576 745505 768946 89104420
Hypersensitivity 640.13 11.46 6187 748894 448490 89424876
Haematochezia 634.09 11.46 1648 753433 69265 89804101
Drug level decreased 628.79 11.46 573 754508 9157 89864209
Platelet count decreased 625.67 11.46 182 754899 136787 89736579
Neuropathy peripheral 623.84 11.46 183 754898 136787 89736579
Drug abuse 621.83 11.46 13 755068 82334 89791032
Helicobacter infection 616.79 11.46 3608 751473 223242 89650124
Tuberculosis 604.43 11.46 629 754452 11920 89861446
Duodenal ulcer perforation 582.58 11.46 3490 751591 217798 89655568
Anal fissure 566.56 11.46 421 754660 4964 89868402
Electrocardiogram QT prolonged 565.71 11.46 7 755074 72449 89800917
Cardiac arrest 564.41 11.46 97 754984 104838 89768528
Maternal exposure during pregnancy 559.42 11.46 5005 750076 355058 89518308
Blood pressure fluctuation 551.00 11.46 1296 753785 51117 89822249
Seizure 533.23 11.46 304 754777 152325 89721041
Faecal calprotectin increased 528.79 11.46 359 754722 3628 89869738
Skin cancer 528.21 11.46 607 754474 12912 89860454
Injection site erythema 512.64 11.46 99 754982 98403 89774963
Exposure during pregnancy 505.13 11.46 3560 751521 234850 89638516
Pancytopenia 501.52 11.46 187 754894 120076 89753290
Transplant dysfunction 500.62 11.46 388 754693 4894 89868472
Cardiac failure 490.06 11.46 151 754930 109345 89764021
Atrial fibrillation 487.33 11.46 252 754829 133359 89740007
Constipation 477.02 11.46 1014 754067 279381 89593985
Basal cell carcinoma 469.68 11.46 929 754152 32460 89840906
Hyperkalaemia 462.17 11.46 18 755063 64946 89808420
Balance disorder 458.27 11.46 121 754960 96959 89776407
Frequent bowel movements 455.48 11.46 1270 753811 55665 89817701
Pulmonary tuberculosis 447.11 11.46 350 754731 4484 89868882
Neutrophil count decreased 440.13 11.46 43 755038 71489 89801877
Anal fistula 431.91 11.46 327 754754 3974 89869392
Thrombocytopenia 419.37 11.46 682 754399 208043 89665323
Disseminated tuberculosis 416.13 11.46 288 754793 3011 89870355
Dehydration 414.91 11.46 610 754471 193837 89679529
Uveitis 408.98 11.46 580 754501 15323 89858043
Hallucination 407.54 11.46 39 755042 65920 89807446
Suicide attempt 407.00 11.46 69 755012 75330 89798036
Bradycardia 400.56 11.46 102 754979 83745 89789621
Coma 399.81 11.46 63 755018 72569 89800797
Hypoglycaemia 399.75 11.46 54 755027 69794 89803572
Colectomy 399.21 11.46 283 754798 3084 89870282
Folliculitis 399.12 11.46 2993 752088 201360 89672006
Diarrhoea 393.72 11.46 5488 749593 933702 88939664
Hypokalaemia 388.58 11.46 313 754768 130803 89742563
Musculoskeletal stiffness 386.52 11.46 3973 751108 292559 89580807
Psoriatic arthropathy 385.02 11.46 3233 751848 225102 89648264
Renal failure 380.49 11.46 319 754762 130688 89742678
Blood creatinine increased 379.05 11.46 185 754896 101201 89772165
Cognitive disorder 375.78 11.46 63 755018 69344 89804022
C-reactive protein abnormal 373.81 11.46 2069 753012 125360 89748006
Asthenia 370.47 11.46 2764 752317 530987 89342379
Blood glucose increased 363.43 11.46 169 754912 95077 89778289
Depressed level of consciousness 362.53 11.46 81 755000 72703 89800663
Sedation 362.12 11.46 8 755073 48163 89825203
Pyoderma gangrenosum 359.37 11.46 298 754783 4166 89869200
Urinary tract infection 356.16 11.46 1326 753755 304306 89569060
Breast cancer 355.59 11.46 1121 753960 52640 89820726
Cardiac failure congestive 354.18 11.46 190 754891 98504 89774862
Sleep disorder due to general medical condition, insomnia type 350.17 11.46 2048 753033 126646 89746720
Tremor 346.22 11.46 461 754620 152712 89720654
Agitation 343.75 11.46 70 755011 67028 89806338
Cardio-respiratory arrest 342.53 11.46 57 755024 63083 89810283
Rheumatic fever 338.54 11.46 2311 752770 150810 89722556
Gastrointestinal haemorrhage 338.41 11.46 164 754917 90084 89783282
Intestinal stenosis 337.82 11.46 253 754828 3021 89870345
Irritable bowel syndrome 336.37 11.46 2912 752169 204536 89668830
Metabolic acidosis 333.43 11.46 37 755044 55639 89817727
Dry skin 331.85 11.46 159 754922 87914 89785452
Rhabdomyolysis 328.38 11.46 26 755055 51230 89822136
Epistaxis 327.96 11.46 149 754932 84976 89788390
Red blood cell sedimentation rate increased 325.23 11.46 1458 753623 81137 89792229
Dyspnoea exertional 324.69 11.46 99 754982 72189 89801177
Device expulsion 323.53 11.46 3 755078 40883 89832483
Mucosal inflammation 319.41 11.46 49 755032 57576 89815790
Lactic acidosis 316.69 11.46 28 755053 50435 89822931
Ovarian cyst 315.75 11.46 539 754542 16779 89856587
Nausea 311.95 11.46 6967 748114 1103349 88770017
Hyperglycaemia 310.03 11.46 32 755049 50938 89822428
Inflammation 309.13 11.46 2544 752537 176048 89697318
Anal abscess 307.55 11.46 304 754777 5404 89867962
Cough 306.94 11.46 1809 753272 367153 89506213
Psoriasis 305.50 11.46 2194 752887 145560 89727806
Poor venous access 304.95 11.46 568 754513 18959 89854407
Neoplasm progression 304.44 11.46 16 755065 44470 89828896
Muscle injury 302.87 11.46 2511 752570 174143 89699223
Hypoxia 302.78 11.46 112 754969 72287 89801079
Blood iron abnormal 300.23 11.46 257 754824 3763 89869603
Impaired healing 297.51 11.46 3122 751959 231077 89642289
Wrong technique in product usage process 297.17 11.46 112 754969 71459 89801907
Injection site swelling 295.21 11.46 68 755013 59771 89813595
Drug specific antibody 295.21 11.46 210 754871 2302 89871064
Pulmonary embolism 293.32 11.46 396 754685 130424 89742942
Therapy interrupted 288.50 11.46 38 755043 50070 89823296
Haemoglobin decreased 284.27 11.46 575 754506 161381 89711985
Dysarthria 282.95 11.46 55 755026 54427 89818939
Pain 282.26 11.46 10544 744537 985797 88887569
Myelosuppression 278.53 11.46 54 755027 53537 89819829
Cerebrovascular accident 276.91 11.46 374 754707 123159 89750207
Therapeutic response shortened 276.43 11.46 598 754483 22281 89851085
Loss of personal independence in daily activities 273.87 11.46 2008 753073 134097 89739269
Infection 273.74 11.46 4387 750694 357707 89515659
Dysphagia 273.51 11.46 319 754762 111959 89761407
Vision blurred 273.40 11.46 309 754772 109984 89763382
Therapeutic product effect incomplete 271.34 11.46 2637 752444 191259 89682107
C-reactive protein increased 271.29 11.46 2502 752579 178887 89694479
International normalised ratio increased 269.76 11.46 37 755044 47279 89826087
Swollen joint count increased 266.68 11.46 1713 753368 109493 89763873
Bone pain 260.70 11.46 95 754986 61888 89811478
Weight increased 256.63 11.46 4898 750183 413029 89460337
Feeling abnormal 256.58 11.46 639 754442 166596 89706770
Respiratory failure 254.96 11.46 369 754712 118049 89755317
Injection site pruritus 254.24 11.46 67 755014 53767 89819599
Skin exfoliation 250.70 11.46 126 754955 67787 89805579
Drug reaction with eosinophilia and systemic symptoms 247.20 11.46 32 755049 42726 89830640
Abscess 247.07 11.46 510 754571 18381 89854985
Pulmonary oedema 246.51 11.46 104 754977 61976 89811390
Transplant rejection 245.79 11.46 407 754674 12351 89861015
Blood cholesterol increased 243.35 11.46 2728 752353 205284 89668082
Injection site bruising 241.57 11.46 68 755013 52239 89821127
Ill-defined disorder 241.50 11.46 2479 752602 182412 89690954
Blood bilirubin increased 240.84 11.46 37 755044 43433 89829933
Oedema peripheral 237.67 11.46 1222 753859 256693 89616673
Orthostatic hypotension 233.11 11.46 35 755046 41792 89831574
Mucous stools 232.23 11.46 252 754829 5019 89868347
Encephalopathy 230.66 11.46 52 755029 46392 89826974
Type 2 diabetes mellitus 229.42 11.46 2647 752434 200597 89672769
Erythema nodosum 226.97 11.46 259 754822 5465 89867901
Full blood count decreased 226.90 11.46 4 755077 29685 89843681
Hypervolaemia 226.64 11.46 11 755070 32746 89840620
Acne 226.10 11.46 634 754447 27873 89845493
Mental status changes 226.00 11.46 48 755033 44631 89828735
Hypomagnesaemia 225.35 11.46 19 755062 35569 89837797
Mobility decreased 221.68 11.46 3121 751960 247613 89625753
Drug level above therapeutic 220.52 11.46 257 754824 5552 89867814
Full blood count abnormal 219.96 11.46 24 755057 36573 89836793
Pulmonary hypertension 218.57 11.46 44 755037 42479 89830887
Overdose 218.24 11.46 634 754447 157075 89716291
Disturbance in attention 218.01 11.46 61 755020 47048 89826318
Hypothyroidism 217.46 11.46 85 754996 53042 89820324
Red blood cell sedimentation rate abnormal 216.78 11.46 563 754518 23641 89849725
Dizziness 216.36 11.46 3530 751551 585754 89287612
Rheumatoid arthritis 216.12 11.46 4231 750850 358383 89514983
Suicidal ideation 215.43 11.46 179 754902 73676 89799690
Dysgeusia 213.65 11.46 85 754996 52475 89820891
Disorientation 211.97 11.46 53 755028 44061 89829305
Drug hypersensitivity 211.94 11.46 5207 749874 458402 89414964
Adverse event 210.33 11.46 1686 753395 115732 89757634
Renal impairment 210.19 11.46 346 754735 105075 89768291
Knee arthroplasty 209.14 11.46 1297 753784 81885 89791481
Cytokine release syndrome 208.89 11.46 5 755076 27968 89845398
Plasma cell myeloma 206.23 11.46 44 755037 40784 89832582
Ileostomy 206.09 11.46 153 754928 1801 89871565
Intentional self-injury 205.72 11.46 9 755072 29325 89844041
Palmar-plantar erythrodysaesthesia syndrome 205.54 11.46 6 755075 28017 89845349
Blister 205.30 11.46 3123 751958 251875 89621491
Irritability 200.69 11.46 29 755052 35633 89837733
Deep vein thrombosis 199.69 11.46 283 754798 91337 89782029
Hip arthroplasty 198.37 11.46 1199 753882 75009 89798357
Urinary retention 198.34 11.46 37 755044 37707 89835659
Rash 197.34 11.46 8307 746774 787793 89085573
Unresponsive to stimuli 196.87 11.46 39 755042 38082 89835284
Drug withdrawal syndrome 194.47 11.46 11 755070 28712 89844654
Acute respiratory failure 194.14 11.46 58 755023 42860 89830506
Sepsis 192.20 11.46 807 754274 179007 89694359
Histoplasmosis disseminated 192.09 11.46 157 754924 2148 89871218
Aphasia 191.59 11.46 59 755022 42753 89830613
Toxic epidermal necrolysis 191.32 11.46 23 755058 32505 89840861
Altered state of consciousness 191.25 11.46 20 755061 31512 89841854
Agranulocytosis 191.18 11.46 31 755050 34971 89838395
Flushing 190.99 11.46 1328 753753 87163 89786203
Sopor 189.67 11.46 3 755078 24641 89848725
Dyspnoea 189.57 11.46 5743 749338 875212 88998154
Blood calcium decreased 188.70 11.46 17 755064 30165 89843201
Accidental exposure to product 188.49 11.46 59 755022 42307 89831059
Chronic obstructive pulmonary disease 188.29 11.46 202 754879 73627 89799739
Multiple organ dysfunction syndrome 188.00 11.46 175 754906 68161 89805205
Fibromyalgia 187.73 11.46 2581 752500 203688 89669678
Device dislocation 185.81 11.46 22 755059 31460 89841906
Hepatic function abnormal 183.05 11.46 78 755003 46210 89827156
Pneumonia aspiration 182.17 11.46 57 755024 40883 89832483
Pulmonary arterial hypertension 180.52 11.46 9 755072 26178 89847188
Device issue 178.46 11.46 19 755062 29518 89843848
Back pain 178.13 11.46 1735 753346 315440 89557926
Dyskinesia 177.28 11.46 43 755038 36491 89836875
Dry eye 177.02 11.46 134 754947 57797 89815569
General physical health deterioration 176.36 11.46 4035 751046 351080 89522286
Ascites 175.56 11.46 89 754992 47651 89825715
Lethargy 174.52 11.46 161 754920 62978 89810388
Clostridium difficile infection 173.24 11.46 679 754402 35566 89837800
Lymphocyte count decreased 172.55 11.46 40 755041 35010 89838356
Osteonecrosis of jaw 171.23 11.46 56 755025 39047 89834319
Liver injury 168.33 11.46 2166 752915 168401 89704965
Granuloma skin 167.19 11.46 311 754770 10369 89862997
Ileal stenosis 166.15 11.46 149 754932 2329 89871037
Haematoma 165.65 11.46 59 755022 38989 89834377
Blood urea increased 161.56 11.46 29 755052 30384 89842982
No adverse event 161.44 11.46 197 754884 67785 89805581
Lower respiratory tract infection 161.33 11.46 2960 752121 247699 89625667
Blood parathyroid hormone decreased 161.17 11.46 331 754750 11885 89861481
Hypophagia 159.96 11.46 50 755031 35887 89837479
Neurotoxicity 159.67 11.46 4 755077 21463 89851903
Syncope 158.68 11.46 569 754512 132094 89741272
Myocardial infarction 158.57 11.46 410 754671 105562 89767804
Myalgia 158.30 11.46 835 754246 174290 89699076
Cerebral haemorrhage 157.34 11.46 46 755035 34476 89838890
Cholestasis 157.17 11.46 53 755028 36246 89837120
Cardiac disorder 156.03 11.46 146 754935 56726 89816640
Gastrointestinal disorder 155.15 11.46 3002 752079 253685 89619681
Pulmonary fibrosis 154.69 11.46 1471 753610 106032 89767334
Panniculitis 153.53 11.46 359 754722 14099 89859267
Anxiety 153.40 11.46 1745 753336 308027 89565339
Therapy cessation 150.77 11.46 57 755024 36304 89837062
Respiratory arrest 150.70 11.46 45 755036 33266 89840100
Injection site haemorrhage 150.44 11.46 27 755054 28291 89845075
Hallucination, visual 149.94 11.46 11 755070 23081 89850285
Aggression 149.34 11.46 22 755059 26646 89846720
Upper gastrointestinal haemorrhage 149.03 11.46 11 755070 22965 89850401
Blood potassium decreased 148.93 11.46 108 754973 47619 89825747
Peritoneal tuberculosis 148.39 11.46 79 755002 487 89872879
Rash maculo-papular 148.01 11.46 78 755003 40855 89832511
Arthritis 145.91 11.46 2078 753003 165237 89708129
Withdrawal syndrome 145.48 11.46 11 755070 22513 89850853
Blood creatine phosphokinase increased 145.02 11.46 51 755030 33972 89839394
Blood alkaline phosphatase increased 144.63 11.46 113 754968 47966 89825400
Urinary incontinence 144.30 11.46 66 755015 37500 89835866
Muscle spasticity 142.13 11.46 58 755023 35264 89838102
Polyarthritis 140.53 11.46 403 754678 17947 89855419
Melaena 140.24 11.46 57 755024 34740 89838626
Depressed mood 140.06 11.46 127 754954 50095 89823271
Stevens-Johnson syndrome 139.78 11.46 36 755045 29340 89844026
Generalised tonic-clonic seizure 139.33 11.46 58 755023 34845 89838521
Device malfunction 139.09 11.46 9 755072 20968 89852398
Obstructive airways disorder 138.87 11.46 24 755057 25845 89847521
Serum sickness 138.30 11.46 159 754922 3383 89869983
Bone marrow failure 137.85 11.46 48 755033 32173 89841193
Emotional distress 136.85 11.46 67 755014 36595 89836771
Vomiting 136.08 11.46 5282 749799 783011 89090355
Pleural effusion 133.49 11.46 481 754600 111510 89761856
Herpes zoster 133.17 11.46 1289 753792 93355 89780011
Sinus disorder 133.13 11.46 60 755021 34387 89838979
Injection site rash 132.95 11.46 21 755060 24152 89849214
Diabetic ketoacidosis 132.45 11.46 22 755059 24385 89848981
Metastases to bone 131.90 11.46 26 755055 25479 89847887
Psychotic disorder 131.10 11.46 48 755033 31182 89842184
Bone erosion 130.30 11.46 822 754259 52199 89821167
Leukopenia 129.92 11.46 418 754663 100292 89773074
Neutropenic sepsis 129.03 11.46 5 755076 18125 89855241
Demyelination 128.63 11.46 238 754843 7902 89865464
Ventricular tachycardia 128.17 11.46 25 755056 24683 89848683
Right ventricular failure 128.06 11.46 8 755073 19197 89854169
Body temperature fluctuation 127.86 11.46 124 754957 2151 89871215
Rheumatoid nodule 127.41 11.46 414 754667 19752 89853614
Acute myocardial infarction 126.87 11.46 66 755015 34824 89838542
Facet joint syndrome 126.85 11.46 1316 753765 97073 89776293
Transient ischaemic attack 126.71 11.46 104 754977 43072 89830294
Status epilepticus 125.44 11.46 8 755073 18866 89854500
Ejection fraction decreased 125.25 11.46 32 755049 26221 89847145
Thrombosis 125.15 11.46 264 754817 72987 89800379
Eosinophilia 124.69 11.46 41 755040 28492 89844874
Lymphoma 124.66 11.46 319 754762 13272 89860094
Product dose omission in error 124.36 11.46 13 755068 20490 89852876
Haemoptysis 124.21 11.46 61 755020 33259 89840107
Abnormal behaviour 123.68 11.46 20 755061 22608 89850758
Blood sodium decreased 123.66 11.46 38 755043 27575 89845791
Cardiogenic shock 122.30 11.46 27 755054 24441 89848925
Pneumonia 122.24 11.46 4221 750860 633838 89239528
Injection site mass 121.92 11.46 19 755062 22071 89851295
Product administration error 120.81 11.46 35 755046 26388 89846978
Respiratory tract infection 119.52 11.46 192 754889 58886 89814480
Dysuria 119.28 11.46 92 754989 39309 89834057
Affect lability 119.03 11.46 8 755073 18055 89855311
Sinusitis bacterial 118.90 11.46 111 754970 1832 89871534
Drug tolerance decreased 118.14 11.46 556 754525 31574 89841792
Arrhythmia 118.11 11.46 107 754974 42225 89831141
Accidental overdose 117.76 11.46 44 755037 28229 89845137
Hemiparesis 117.48 11.46 59 755022 31760 89841606
Joint range of motion decreased 117.18 11.46 1682 753399 133961 89739405
Chronic kidney disease 116.50 11.46 148 754933 50043 89823323
Malignant melanoma 116.20 11.46 296 754785 12280 89861086
Sinus tachycardia 116.06 11.46 46 755035 28467 89844899
Productive cough 114.63 11.46 299 754782 76764 89796602
Sleep apnoea syndrome 114.05 11.46 61 755020 31686 89841680
Circulatory collapse 113.84 11.46 33 755048 24871 89848495
Oxygen saturation decreased 113.81 11.46 484 754597 106999 89766367
Hepatic failure 113.75 11.46 98 754983 39630 89833736
Grip strength decreased 113.14 11.46 1225 753856 91351 89782015
Aphthous ulcer 112.94 11.46 359 754722 16928 89856438
Restlessness 112.54 11.46 80 755001 35640 89837726
Femur fracture 112.12 11.46 131 754950 45951 89827415
Sciatica 111.89 11.46 1315 753766 100067 89773299
Inappropriate antidiuretic hormone secretion 111.78 11.46 15 755066 19490 89853876
Hallucination, auditory 111.70 11.46 5 755076 15970 89857396
Hyperlipidaemia 111.13 11.46 27 755054 22889 89850477
Defaecation urgency 110.80 11.46 192 754889 6050 89867316
Speech disorder 110.47 11.46 130 754951 45455 89827911
Sinus bradycardia 110.28 11.46 8 755073 16944 89856422
Schizophrenia 110.10 11.46 3 755078 14911 89858455
Hodgkin's disease 109.63 11.46 72 755009 685 89872681
Exposure to SARS-CoV-2 109.38 11.46 118 754963 2334 89871032
Myoclonus 109.24 11.46 15 755066 19153 89854213
Device difficult to use 109.21 11.46 10 755071 17515 89855851
Extrapyramidal disorder 108.08 11.46 7 755074 16296 89857070
Musculoskeletal deformity 107.71 11.46 104 754977 1794 89871572
Angioedema 107.36 11.46 238 754843 64638 89808728
Histoplasmosis 107.08 11.46 111 754970 2093 89871273
Joint destruction 106.83 11.46 297 754784 12990 89860376
Vertigo 106.82 11.46 267 754814 69544 89803822
Injury 106.58 11.46 2270 752811 195079 89678287
Poisoning 105.63 11.46 5 755076 15212 89858154
Tinnitus 105.44 11.46 122 754959 42980 89830386
Pollakiuria 105.20 11.46 73 755008 32932 89840434
Swelling face 104.69 11.46 338 754743 81014 89792352
Large intestinal stenosis 104.15 11.46 116 754965 2381 89870985
Pneumonia legionella 104.00 11.46 102 754979 1795 89871571
Mydriasis 103.99 11.46 5 755076 15007 89858359
Labelled drug-drug interaction medication error 103.85 11.46 4 755077 14578 89858788
Decreased appetite 103.51 11.46 2368 752713 374172 89499194
Hepatocellular injury 103.50 11.46 56 755025 28902 89844464
Dysphonia 103.11 11.46 233 754848 62851 89810515
Acute hepatic failure 102.93 11.46 30 755051 22531 89850835
Renal disorder 102.90 11.46 98 754983 37761 89835605
Motor dysfunction 102.88 11.46 18 755063 19212 89854154
Respiratory depression 102.34 11.46 7 755074 15568 89857798
Vascular access complication 102.20 11.46 113 754968 2300 89871066
Muscle twitching 101.92 11.46 37 755044 24165 89849201
Lymph node tuberculosis 101.82 11.46 71 755010 752 89872614
Therapeutic response decreased 101.76 11.46 1170 753911 88559 89784807
Anal stenosis 101.70 11.46 61 755020 487 89872879
Stomatitis 101.20 11.46 3001 752080 271697 89601669
Dermatitis atopic 100.36 11.46 35 755046 23437 89849929
Pouchitis 99.53 11.46 65 755016 612 89872754
Abdominal pain 99.40 11.46 4137 750944 391584 89481782
Anuria 99.32 11.46 6 755075 14812 89858554
Haematemesis 99.26 11.46 81 755000 33645 89839721
Nightmare 98.91 11.46 29 755052 21696 89851670
Mammoplasty 98.69 11.46 67 755014 677 89872689
Tenosynovitis 98.37 11.46 306 754775 14261 89859105
Intentional product misuse 98.28 11.46 398 754683 89206 89784160
Bursitis 97.72 11.46 1591 753490 130063 89743303
Cervical dysplasia 97.69 11.46 143 754938 3891 89869475
Jaundice 97.08 11.46 77 755004 32440 89840926
Small intestinal resection 97.01 11.46 64 755017 614 89872752
Parkinsonism 96.42 11.46 5 755076 14060 89859306
Insomnia 96.25 11.46 2081 753000 331393 89541973
Coronary artery disease 96.20 11.46 83 754998 33540 89839826
Ileocaecal resection 96.15 11.46 59 755022 493 89872873
Human antichimeric antibody positive 96.00 11.46 95 754986 1691 89871675
Bronchitis 96.00 11.46 813 754268 152114 89721252
Paradoxical psoriasis 95.98 11.46 51 755030 313 89873053
Gamma-glutamyltransferase increased 95.48 11.46 105 754976 37847 89835519
Blood pressure diastolic abnormal 95.29 11.46 24 755057 19857 89853509
Sneezing 95.28 11.46 66 755015 29803 89843563
B-cell lymphoma 95.26 11.46 134 754947 3512 89869854
Subdural haematoma 94.92 11.46 13 755068 16632 89856734
Prescribed overdose 94.69 11.46 1236 753845 96389 89776977
Delusion 94.63 11.46 5 755076 13835 89859531
Faecal calprotectin abnormal 94.60 11.46 42 755039 161 89873205
Ankylosing spondylitis 94.41 11.46 282 754799 12851 89860515
Non-Hodgkin's lymphoma 94.24 11.46 84 754997 1302 89872064
Blood potassium increased 93.92 11.46 28 755053 20721 89852645
Dystonia 93.89 11.46 14 755067 16805 89856561
Lip dry 93.71 11.46 1268 753813 99687 89773679
Pancreatitis acute 93.45 11.46 78 755003 32037 89841329
Coeliac disease 93.03 11.46 664 754417 43946 89829420
Enthesopathy 92.84 11.46 227 754854 9177 89864189
Coordination abnormal 92.78 11.46 31 755050 21325 89852041
Blood pressure systolic abnormal 92.43 11.46 24 755057 19454 89853912
Diarrhoea haemorrhagic 92.39 11.46 245 754836 10418 89862948
Cerebral infarction 91.37 11.46 54 755027 26542 89846824
Haematuria 90.86 11.46 94 754987 34843 89838523
Electrolyte imbalance 90.76 11.46 42 755039 23703 89849663
Ataxia 89.99 11.46 20 755061 18022 89855344
Needle issue 89.44 11.46 7 755074 13927 89859439
Unevaluable event 89.30 11.46 203 754878 54645 89818721
Rhinitis allergic 89.17 11.46 16 755065 16769 89856597
Tuberculous pleurisy 89.03 11.46 52 755029 393 89872973
Intestinal anastomosis 87.97 11.46 68 755013 854 89872512
Heart rate irregular 87.80 11.46 418 754663 23850 89849516
Coagulopathy 87.78 11.46 42 755039 23247 89850119
Injection site urticaria 87.78 11.46 21 755060 17990 89855376
Blood glucose decreased 87.17 11.46 43 755038 23386 89849980
Treatment noncompliance 87.05 11.46 188 754893 51539 89821827
Incorrect drug administration rate 86.69 11.46 156 754925 5067 89868299
Liver disorder 86.49 11.46 1456 753625 119813 89753553
Angina pectoris 86.27 11.46 120 754961 39040 89834326
Hypercholesterolaemia 85.90 11.46 1248 753833 99644 89773722
Cytopenia 85.72 11.46 20 755061 17429 89855937
Premature delivery 85.17 11.46 119 754962 38643 89834723
Device breakage 84.93 11.46 9 755072 14035 89859331
Ventricular fibrillation 84.93 11.46 9 755072 14035 89859331
Leukocytosis 84.48 11.46 80 755001 30910 89842456
Eye irritation 84.39 11.46 95 754986 33883 89839483
Injection site warmth 84.23 11.46 21 755060 17494 89855872
Pustular psoriasis 84.16 11.46 342 754739 18214 89855152
Heart rate decreased 83.95 11.46 746 754335 52759 89820607
Skin necrosis 83.92 11.46 321 754760 16620 89856746
Urticaria 83.70 11.46 3292 751789 309442 89563924
Lymphopenia 83.62 11.46 43 755038 22838 89850528
Ileectomy 83.47 11.46 44 755037 265 89873101
Thirst 83.45 11.46 17 755064 16278 89857088
Subarachnoid haemorrhage 83.18 11.46 23 755058 17881 89855485
Contrast media allergy 83.13 11.46 115 754966 2966 89870400
Nasopharyngitis 83.12 11.46 4168 750913 402936 89470430
Antinuclear antibody positive 82.80 11.46 215 754866 9026 89864340
Red blood cell count decreased 82.62 11.46 163 754918 46188 89827178
Body height below normal 82.43 11.46 96 754985 2072 89871294
Pneumocystis jirovecii pneumonia 81.63 11.46 377 754704 21239 89852127
Eye pruritus 81.42 11.46 73 755008 28954 89844412
Brain oedema 81.39 11.46 22 755059 17363 89856003
Antibody test positive 81.30 11.46 112 754969 2877 89870489
Red blood cell sedimentation rate 81.02 11.46 142 754939 4516 89868850
Colectomy total 81.01 11.46 37 755044 154 89873212
Drug level abnormal 80.91 11.46 43 755038 264 89873102
Muscular weakness 80.64 11.46 1223 753858 205443 89667923
Mania 80.61 11.46 11 755070 14113 89859253
Hidradenitis 80.17 11.46 136 754945 4211 89869155
Left ventricular dysfunction 80.09 11.46 13 755068 14656 89858710
Intestinal operation 80.08 11.46 56 755025 596 89872770
Rales 80.05 11.46 17 755064 15810 89857556
Gastrointestinal inflammation 79.72 11.46 174 754907 6522 89866844
Akathisia 79.68 11.46 3 755078 11156 89862210
Hepatic cytolysis 79.48 11.46 84 754997 30832 89842534
Lymphoproliferative disorder 79.47 11.46 134 754947 4128 89869238
Hypoacusis 79.37 11.46 69 755012 27781 89845585
Hyperbilirubinaemia 79.19 11.46 11 755070 13925 89859441
Peripheral swelling 79.15 11.46 4204 750877 408902 89464464
Ischaemic stroke 79.02 11.46 43 755038 22123 89851243
Pneumonitis 79.01 11.46 155 754926 44015 89829351
Aplastic anaemia 78.99 11.46 9 755072 13260 89860106
Tricuspid valve incompetence 78.66 11.46 21 755060 16710 89856656
Anhedonia 78.56 11.46 4 755077 11427 89861939
Dementia 78.43 11.46 51 755030 23810 89849556
Transfusion 78.43 11.46 24 755057 17464 89855902
Diplopia 78.42 11.46 74 755007 28640 89844726
Chromaturia 78.02 11.46 31 755050 19156 89854210
Blood lactate dehydrogenase increased 77.93 11.46 61 755020 25871 89847495
Rectal abscess 77.33 11.46 78 755003 1422 89871944
Cholangitis sclerosing 77.29 11.46 94 754987 2127 89871239
Peripheral venous disease 77.04 11.46 1052 754029 82869 89790497
Gastritis 76.89 11.46 144 754937 41609 89831757
Metastases to liver 76.63 11.46 76 755005 28731 89844635
Head injury 76.58 11.46 88 754993 31100 89842266
Glomerular filtration rate decreased 76.36 11.46 23 755058 16909 89856457
Tumour lysis syndrome 76.34 11.46 4 755077 11148 89862218
Diabetes mellitus inadequate control 76.28 11.46 30 755051 18654 89854712
Exposure via skin contact 76.02 11.46 3 755078 10702 89862664
Hiatus hernia 75.78 11.46 60 755021 25301 89848065
Dermatitis psoriasiform 75.52 11.46 102 754979 2570 89870796
Skin haemorrhage 75.46 11.46 42 755039 21338 89852028
Metastases to central nervous system 75.27 11.46 26 755055 17516 89855850
Hypophosphataemia 75.03 11.46 16 755065 14838 89858528
Complication associated with device 74.96 11.46 34 755047 19415 89853951
Acidosis 74.91 11.46 9 755072 12727 89860639
Alanine aminotransferase increased 74.76 11.46 628 754453 117710 89755656
Gastrooesophageal reflux disease 74.63 11.46 957 754124 165380 89707986
Obesity 74.59 11.46 1265 753816 104242 89769124
Hip fracture 74.23 11.46 100 754981 32977 89840389
Injection site induration 74.11 11.46 3 755078 10465 89862901
Urine output decreased 73.90 11.46 9 755072 12594 89860772
Pain in jaw 73.82 11.46 183 754898 47802 89825564
Hypertension 73.77 11.46 4584 750497 452948 89420418
Onychomycosis 73.73 11.46 549 754532 36827 89836539
Haemorrhage intracranial 73.26 11.46 18 755063 15144 89858222
Psychomotor hyperactivity 73.08 11.46 10 755071 12803 89860563
Acute generalised exanthematous pustulosis 72.93 11.46 13 755068 13690 89859676
DNA antibody positive 72.76 11.46 43 755038 333 89873033
Squamous cell carcinoma 72.71 11.46 217 754864 9884 89863482
Burning sensation 72.67 11.46 277 754804 63175 89810191
Cholelithiasis 72.65 11.46 211 754870 52295 89821071
Swollen tongue 72.48 11.46 173 754908 45783 89827583
Hypothermia 72.37 11.46 20 755061 15555 89857811
Deep vein thrombosis postoperative 72.26 11.46 905 754176 69904 89803462
Proctocolectomy 71.80 11.46 28 755053 70 89873296
Aspartate aminotransferase increased 71.66 11.46 532 754549 102405 89770961
Listeriosis 71.03 11.46 80 755001 1663 89871703
Respiratory tract congestion 71.00 11.46 74 755007 27336 89846030
Neuralgia 70.93 11.46 95 754986 31405 89841961
Anal cancer 70.29 11.46 50 755031 548 89872818
Device leakage 70.28 11.46 3 755078 9988 89863378
Deformity 69.93 11.46 242 754839 11928 89861438
Nervousness 69.53 11.46 110 754971 33946 89839420
Onychomadesis 69.44 11.46 636 754445 45362 89828004
Gait inability 69.44 11.46 1654 753427 144802 89728564
Hemiplegia 69.26 11.46 24 755057 16136 89857230
Insurance issue 68.97 11.46 6 755075 10952 89862414
Skin discolouration 68.96 11.46 168 754913 44147 89829219
Cardiac failure acute 68.78 11.46 9 755072 11920 89861446
Hepatosplenic T-cell lymphoma 68.67 11.46 52 755029 632 89872734
Polyneuropathy 68.25 11.46 38 755043 19303 89854063
Thrombotic microangiopathy 68.13 11.46 23 755058 15720 89857646
Depression 67.96 11.46 1945 753136 298656 89574710
Haematocrit decreased 67.96 11.46 155 754926 41677 89831689
Seasonal allergy 67.89 11.46 55 755026 22928 89850438
Pericardial effusion 66.97 11.46 128 754953 36705 89836661
Myelodysplastic syndrome 66.93 11.46 46 755035 20857 89852509
Premature labour 66.71 11.46 254 754827 13122 89860244
Therapy non-responder 66.69 11.46 1550 753531 135154 89738212
Contraindication to vaccination 66.45 11.46 36 755045 231 89873135
Salmonellosis 66.14 11.46 67 755014 1228 89872138
Abnormal dreams 66.10 11.46 8 755073 11249 89862117
Anorectal disorder 65.92 11.46 83 754998 1948 89871418
Hyperhidrosis 65.76 11.46 772 754309 135533 89737833
Colitis ulcerative 65.73 11.46 780 754301 59486 89813880
Nasal polyps 65.73 11.46 7 755074 10873 89862493
Skin burning sensation 65.72 11.46 41 755040 19570 89853796
Throat tightness 65.08 11.46 445 754636 29039 89844327
Arthrodesis 64.74 11.46 101 754980 2911 89870455
Mood altered 64.49 11.46 31 755050 17113 89856253
Disability 64.39 11.46 569 754512 40176 89833190
Bronchitis chronic 64.33 11.46 130 754951 4613 89868753
Muscle rigidity 63.52 11.46 20 755061 14289 89859077
Hepatic encephalopathy 63.41 11.46 18 755063 13754 89859612
Nail disorder 63.33 11.46 762 754319 58305 89815061
Tonsillitis 63.32 11.46 163 754918 6806 89866560
Infectious mononucleosis 63.08 11.46 81 755000 1940 89871426
Paranoia 63.00 11.46 15 755066 12893 89860473
Product prescribing error 62.85 11.46 96 754985 30049 89843317
Hysterectomy 62.82 11.46 226 754855 11358 89862008
Mesenteritis 62.78 11.46 38 755043 309 89873057
Haemodynamic instability 62.77 11.46 11 755070 11728 89861638
Thinking abnormal 62.72 11.46 11 755070 11721 89861645
Asthma 62.57 11.46 1537 753544 240623 89632743
Adverse drug reaction 62.21 11.46 1340 753741 115361 89758005
Visual acuity reduced 62.00 11.46 62 755019 23348 89850018
Surgical failure 61.98 11.46 57 755024 922 89872444
Dialysis 61.95 11.46 10 755071 11319 89862047
Jaundice cholestatic 61.87 11.46 6 755075 10037 89863329
Atypical mycobacterial infection 61.82 11.46 72 755009 1554 89871812
Nephropathy toxic 61.43 11.46 15 755066 12673 89860693
Restless legs syndrome 61.26 11.46 58 755023 22412 89850954
Fear 61.10 11.46 31 755050 16591 89856775
Blood calcium increased 60.89 11.46 13 755068 12045 89861321
Blood lactic acid increased 60.56 11.46 3 755078 8775 89864591
Ulcer 60.40 11.46 475 754606 32407 89840959
Wound infection 60.38 11.46 1233 753848 105169 89768197
Cervix carcinoma 60.35 11.46 104 754977 3262 89870104
Mental impairment 60.24 11.46 32 755049 16688 89856678
Shock haemorrhagic 60.22 11.46 14 755067 12231 89861135
Proteinuria 60.19 11.46 63 755018 23228 89850138
Blood loss anaemia 60.05 11.46 7 755074 10133 89863233
Toxic encephalopathy 59.93 11.46 3 755078 8696 89864670
Pseudopolyp 59.91 11.46 39 755042 365 89873001
Arterial occlusive disease 59.70 11.46 15 755066 12431 89860935
Mycobacterium marinum infection 59.44 11.46 35 755046 269 89873097
Autoimmune disorder 59.39 11.46 934 754147 75810 89797556
Gangrene 58.97 11.46 17 755064 12859 89860507
Shock 58.70 11.46 93 754988 28685 89844681
Stress cardiomyopathy 58.69 11.46 19 755062 13336 89860030
Wheelchair user 58.67 11.46 170 754911 7615 89865751
Vaginal haemorrhage 58.33 11.46 107 754974 31164 89842202
Lip swelling 58.03 11.46 149 754932 38461 89834905
Lymphoedema 57.96 11.46 21 755060 13732 89859634
Pain in extremity 57.79 11.46 3116 751965 447413 89425953
Hypocalcaemia 57.36 11.46 172 754909 42196 89831170
Osteonecrosis 57.22 11.46 81 755000 26160 89847206
Renal tubular necrosis 56.80 11.46 25 755056 14530 89858836
Meningitis listeria 56.50 11.46 47 755034 660 89872706
Tubulointerstitial nephritis 56.49 11.46 77 755004 25266 89848100
Troponin increased 56.44 11.46 20 755061 13261 89860105
Hypotonia 56.32 11.46 13 755068 11413 89861953
Cardiomegaly 56.26 11.46 45 755036 18880 89854486
Type IV hypersensitivity reaction 56.12 11.46 110 754971 3816 89869550
Bone disorder 55.95 11.46 66 755015 23054 89850312
Hypovolaemia 55.86 11.46 17 755064 12414 89860952
Intentional dose omission 55.79 11.46 40 755041 17743 89855623
Eye pain 55.79 11.46 185 754896 43983 89829383
Spinal column injury 55.72 11.46 79 755002 2086 89871280
Headache 55.69 11.46 6316 748765 856430 89016936
Metastases to lung 55.59 11.46 32 755049 15959 89857407
Palpitations 55.43 11.46 803 754278 135925 89737441
Respiratory acidosis 55.30 11.46 3 755078 8116 89865250
Cholecystitis chronic 55.27 11.46 8 755073 9818 89863548
Breast cancer stage III 54.86 11.46 999 754082 83448 89789918
Blood pressure abnormal 54.39 11.46 50 755031 19595 89853771
Vaginal fistula 54.35 11.46 43 755038 560 89872806
Rib fracture 54.33 11.46 85 754996 26350 89847016
Renal injury 53.90 11.46 10 755071 10233 89863133
X-ray abnormal 53.61 11.46 597 754484 44827 89828539
Incorrect dose administered 53.49 11.46 940 754141 77990 89795376
Red cell distribution width decreased 53.40 11.46 78 755003 2118 89871248
Intestinal obstruction 53.34 11.46 508 754573 36623 89836743
Poor quality sleep 53.07 11.46 77 755004 24616 89848750
Product complaint 52.98 11.46 23 755058 13477 89859889
Glycosylated haemoglobin increased 52.89 11.46 32 755049 15530 89857836
Prothrombin time prolonged 52.60 11.46 9 755072 9763 89863603
Blood thyroid stimulating hormone increased 52.56 11.46 7 755074 9148 89864218
Aspiration 52.32 11.46 33 755048 15660 89857706
Adjustment disorder with depressed mood 52.31 11.46 712 754369 56041 89817325
Macular degeneration 52.23 11.46 153 754928 37817 89835549
Ageusia 51.97 11.46 35 755046 16041 89857325
Lacrimation increased 51.92 11.46 91 754990 26971 89846395
Atrial flutter 51.54 11.46 13 755068 10745 89862621
Injection site discolouration 51.47 11.46 8 755073 9312 89864054
Initial insomnia 51.40 11.46 8 755073 9302 89864064
Concomitant disease aggravated 51.31 11.46 16 755065 11502 89861864
Peripheral sensory neuropathy 50.95 11.46 8 755073 9242 89864124
Product storage error 50.91 11.46 56 755025 20185 89853181
Product substitution issue 50.85 11.46 45 755036 17963 89855403
Nephropathy 50.84 11.46 8 755073 9227 89864139
Cardiac murmur 50.74 11.46 46 755035 18148 89855218
Dislocation of vertebra 50.71 11.46 700 754381 55268 89818098
Ileal ulcer 50.56 11.46 53 755028 1013 89872353
Immunodeficiency 50.47 11.46 567 754514 42667 89830699
Infusion site reaction 50.45 11.46 301 754780 18738 89854628
Fracture 50.30 11.46 66 755015 22010 89851356
Eosinophil count increased 50.21 11.46 23 755058 13058 89860308
Febrile bone marrow aplasia 50.20 11.46 10 755071 9728 89863638
Drug tolerance 49.90 11.46 287 754794 17629 89855737
Mitral valve incompetence 49.63 11.46 69 755012 22455 89850911
Abortion spontaneous 49.35 11.46 677 754404 53379 89819987
Sinus congestion 49.25 11.46 96 754985 27328 89846038
Physical disability 49.17 11.46 105 754976 3876 89869490
Tachycardia 48.96 11.46 972 754109 156701 89716665
Sudden death 48.87 11.46 15 755066 10894 89862472
Posterior reversible encephalopathy syndrome 48.66 11.46 69 755012 22270 89851096
Nephrolithiasis 48.65 11.46 624 754457 48461 89824905
Cardiomyopathy 48.55 11.46 58 755023 20148 89853218
Osteopenia 48.20 11.46 73 755008 22929 89850437
Progressive multifocal leukoencephalopathy 48.09 11.46 36 755045 15619 89857747
Oligohydramnios 48.01 11.46 3 755078 7198 89866168
Spinal fracture 47.96 11.46 68 755013 21948 89851418
Renal function test abnormal 47.93 11.46 3 755078 7188 89866178
Atelectasis 47.81 11.46 81 755000 24328 89849038
Vascular device infection 47.48 11.46 20 755061 11932 89861434
Haemolytic anaemia 47.40 11.46 19 755062 11678 89861688
Neutrophil count increased 47.30 11.46 55 755026 19335 89854031
Rash papular 47.26 11.46 60 755021 20295 89853071
Device occlusion 46.88 11.46 10 755071 9272 89864094
Tuberculin test positive 46.88 11.46 99 754982 3626 89869740
Fluid retention 46.82 11.46 488 754593 87603 89785763
Enterostomy 46.71 11.46 24 755057 136 89873230
Polyuria 46.45 11.46 13 755068 10027 89863339
Apathy 46.28 11.46 17 755064 11023 89862343
Ankle arthroplasty 46.28 11.46 84 754997 2747 89870619
Prescribed underdose 46.14 11.46 880 754201 74139 89799227
COVID-19 pneumonia 46.04 11.46 50 755031 18127 89855239
Proctectomy 46.03 11.46 26 755055 183 89873183
Rectal stenosis 45.63 11.46 28 755053 234 89873132
Sensory loss 45.47 11.46 50 755031 18025 89855341
Tonsillar ulcer 45.46 11.46 30 755051 288 89873078
Ventricular extrasystoles 45.38 11.46 27 755054 13223 89860143
Blood test abnormal 45.36 11.46 65 755016 20887 89852479
Hepatitis acute 45.25 11.46 17 755064 10870 89862496
Antinuclear antibody increased 45.20 11.46 55 755026 1245 89872121
Foetal exposure during pregnancy 45.18 11.46 194 754887 42781 89830585
Toxic skin eruption 45.05 11.46 39 755042 15735 89857631
Upper-airway cough syndrome 44.98 11.46 36 755045 15099 89858267
Live birth 44.97 11.46 917 754164 78190 89795176
Temperature intolerance 44.87 11.46 22 755059 12008 89861358
Mental disorder 44.62 11.46 130 754951 32188 89841178
Hyperthyroidism 44.59 11.46 52 755029 18258 89855108
Metabolic encephalopathy 44.46 11.46 3 755078 6749 89866617
Cystitis 44.45 11.46 349 754732 66369 89806997
Illness 44.42 11.46 452 754629 81517 89791849
Nocturia 44.35 11.46 15 755066 10240 89863126
Intestinal fistula 44.29 11.46 49 755032 998 89872368
Gout 44.25 11.46 45 755036 16814 89856552
Anger 44.18 11.46 30 755051 13690 89859676
Transaminases increased 44.13 11.46 160 754921 37032 89836334
Subcutaneous abscess 44.06 11.46 139 754942 6527 89866839
Septic shock 44.01 11.46 468 754613 83692 89789674
Liver function test increased 43.83 11.46 970 754111 83885 89789481
Multiple sclerosis 43.74 11.46 105 754976 27735 89845631
Hyperreflexia 43.71 11.46 3 755078 6654 89866712
Petechiae 43.66 11.46 40 755041 15701 89857665
Salivary hypersecretion 43.53 11.46 11 755070 9081 89864285
Personality change 43.49 11.46 5 755076 7316 89866050
Decubitus ulcer 43.46 11.46 22 755059 11791 89861575
Dermatitis contact 43.42 11.46 30 755051 13565 89859801
Stoma obstruction 43.30 11.46 26 755055 208 89873158
Osteoarthritis 43.25 11.46 2020 753061 193710 89679656
Bundle branch block left 43.02 11.46 7 755074 7878 89865488
Haemodialysis 43.02 11.46 10 755071 8737 89864629
Henoch-Schonlein purpura 42.81 11.46 60 755021 1567 89871799
Genital haemorrhage 42.69 11.46 10 755071 8692 89864674
Infusion site extravasation 42.66 11.46 185 754896 10143 89863223
Activated partial thromboplastin time prolonged 42.58 11.46 7 755074 7818 89865548
Haemorrhage 42.52 11.46 371 754710 68998 89804368
Product label confusion 42.47 11.46 331 754750 22519 89850847
Post-traumatic stress disorder 42.27 11.46 4 755077 6824 89866542
Drug exposure before pregnancy 42.24 11.46 46 755035 920 89872446
Heavy menstrual bleeding 42.20 11.46 66 755015 20464 89852902
Road traffic accident 42.11 11.46 1185 753896 106441 89766925
Amyotrophic lateral sclerosis 42.03 11.46 54 755027 1294 89872072
Granulocytopenia 42.01 11.46 3 755078 6438 89866928
Pneumonia viral 41.92 11.46 165 754916 8658 89864708
Obliterative bronchiolitis 41.88 11.46 78 755003 2603 89870763
Rectal haemorrhage 41.84 11.46 943 754138 81801 89791565
Eating disorder 41.68 11.46 109 754972 27964 89845402
Colostomy 41.44 11.46 53 755028 1264 89872102
Rectal tenesmus 41.43 11.46 50 755031 1122 89872244
Amenorrhoea 41.41 11.46 23 755058 11699 89861667
Supraventricular tachycardia 41.31 11.46 45 755036 16291 89857075
Unintended pregnancy 41.18 11.46 7 755074 7630 89865736
Listeria sepsis 41.15 11.46 40 755041 696 89872670
Hot flush 41.13 11.46 308 754773 59180 89814186
Blood creatine increased 40.79 11.46 5 755076 6962 89866404
Hepatic steatosis 40.57 11.46 164 754917 36781 89836585
Streptococcal infection 40.56 11.46 144 754937 7189 89866177
Blood triglycerides increased 40.56 11.46 33 755048 13728 89859638
Emotional disorder 40.55 11.46 39 755042 14958 89858408
Exercise tolerance decreased 40.54 11.46 7 755074 7544 89865822
Injection site haematoma 40.45 11.46 5 755076 6917 89866449
Nystagmus 40.38 11.46 6 755075 7221 89866145
Myopathy 40.36 11.46 32 755049 13486 89859880
Blood pressure inadequately controlled 40.31 11.46 3 755078 6221 89867145
Drug level increased 40.30 11.46 109 754972 27653 89845713
Oliguria 40.28 11.46 19 755062 10605 89862761
Mean platelet volume decreased 40.18 11.46 81 755000 2869 89870497
Double stranded DNA antibody 40.17 11.46 21 755060 124 89873242
Infusion site erythema 40.02 11.46 33 755048 13637 89859729
Abdominal abscess 39.99 11.46 117 754964 5270 89868096
Hereditary angioedema 39.98 11.46 14 755067 9351 89864015
Acute myeloid leukaemia 39.96 11.46 69 755012 20571 89852795
Pain of skin 39.90 11.46 45 755036 16037 89857329
Fistula discharge 39.87 11.46 47 755034 1028 89872338
Joint arthroplasty 39.87 11.46 89 754992 3388 89869978
Lung disorder 39.86 11.46 1577 753504 148306 89725060
Peptic ulcer haemorrhage 39.81 11.46 48 755033 1076 89872290
Colitis ischaemic 39.75 11.46 27 755054 12319 89861047
Atrioventricular block 39.71 11.46 12 755069 8803 89864563
Blindness 39.57 11.46 103 754978 26465 89846901
Blood uric acid increased 39.53 11.46 8 755073 7696 89865670
Rash macular 39.51 11.46 125 754956 30155 89843211
Skin laceration 39.49 11.46 100 754981 25935 89847431
Vitamin D deficiency 39.47 11.46 53 755028 17503 89855863
Memory impairment 39.45 11.46 1297 753784 195947 89677419
Bradykinesia 39.43 11.46 5 755076 6783 89866583
Rhinorrhoea 39.27 11.46 509 754572 87807 89785559
Catatonia 38.99 11.46 3 755078 6053 89867313
Ankle operation 38.94 11.46 55 755026 1447 89871919
Hyperuricaemia 38.90 11.46 5 755076 6714 89866652
Blepharospasm 38.90 11.46 664 754417 54781 89818585
Tachypnoea 38.79 11.46 74 755007 21235 89852131
Hypertensive crisis 38.67 11.46 55 755026 17729 89855637
Body height decreased 38.65 11.46 26 755055 11923 89861443
Hypercapnia 38.59 11.46 5 755076 6672 89866694
Hospitalisation 38.48 11.46 794 754287 127306 89746060
Extra dose administered 38.29 11.46 14 755067 9104 89864262
Dysstasia 38.17 11.46 96 754985 24956 89848410
Purpura 38.16 11.46 40 755041 14738 89858628
Feeling jittery 38.14 11.46 43 755038 15328 89858038
White blood cell count abnormal 38.07 11.46 8 755073 7496 89865870
Atrioventricular block complete 38.05 11.46 17 755064 9794 89863572
Multiple-drug resistance 38.02 11.46 9 755072 7767 89865599
Immune thrombocytopenia 37.99 11.46 33 755048 13293 89860073
Hepatitis cholestatic 37.94 11.46 12 755069 8549 89864817
Nasal oedema 37.88 11.46 5 755076 6579 89866787
SAPHO syndrome 37.87 11.46 20 755061 121 89873245
Anticipatory anxiety 37.83 11.46 49 755032 1184 89872182
Urine abnormality 37.74 11.46 9 755072 7728 89865638
Hallucinations, mixed 37.68 11.46 3 755078 5886 89867480
Hypogammaglobulinaemia 37.62 11.46 21 755060 10653 89862713
Internal haemorrhage 37.58 11.46 4 755077 6216 89867150
Eyelid ptosis 37.53 11.46 14 755067 8992 89864374
Malignant respiratory tract neoplasm 37.52 11.46 15 755066 41 89873325
Sinusitis 37.52 11.46 3333 751748 339755 89533611
Hydronephrosis 37.48 11.46 29 755052 12373 89860993
Flatulence 37.48 11.46 197 754884 41170 89832196
Gastric ulcer 37.46 11.46 111 754970 27337 89846029
Tooth disorder 37.38 11.46 133 754948 30957 89842409
Product availability issue 37.35 11.46 8 755073 7396 89865970
Skin toxicity 37.03 11.46 6 755075 6773 89866593
Enterocutaneous fistula 36.97 11.46 55 755026 1519 89871847
Hypoalbuminaemia 36.76 11.46 47 755034 15850 89857516
Caesarean section 36.71 11.46 273 754808 18304 89855062
Blood magnesium decreased 36.70 11.46 46 755035 15647 89857719
Tuberculosis gastrointestinal 36.69 11.46 29 755052 377 89872989
Pulmonary congestion 36.69 11.46 66 755015 19367 89853999
Loss of therapeutic response 36.62 11.46 58 755023 1694 89871672
Dental caries 36.60 11.46 25 755056 11372 89861994
Protein urine present 36.37 11.46 7 755074 6977 89866389
Paternal exposure during pregnancy 36.36 11.46 27 755054 318 89873048
Partial seizures 36.31 11.46 8 755073 7252 89866114
Middle insomnia 36.23 11.46 52 755029 16699 89856667
Intervertebral disc degeneration 36.02 11.46 55 755026 17219 89856147
Bacteraemia 35.92 11.46 83 754998 22217 89851149
Low birth weight baby 35.79 11.46 17 755064 9450 89863916
Device failure 35.73 11.46 7 755074 6890 89866476
Anastomotic stenosis 35.71 11.46 29 755052 393 89872973
IgA nephropathy 35.67 11.46 41 755040 872 89872494
Faeces discoloured 35.44 11.46 78 755003 21242 89852124
Chronic recurrent multifocal osteomyelitis 35.36 11.46 15 755066 50 89873316
Lip ulceration 35.36 11.46 65 755016 2147 89871219
Pruritus allergic 35.34 11.46 57 755024 1691 89871675
Hepatotoxicity 35.30 11.46 230 754851 45612 89827754
Exposure via father 35.22 11.46 25 755056 273 89873093
Acute pulmonary oedema 35.01 11.46 18 755063 9562 89863804
Eye movement disorder 34.97 11.46 5 755076 6193 89867173
Diastolic dysfunction 34.86 11.46 9 755072 7324 89866042
Facial pain 34.81 11.46 35 755046 13147 89860219
Back injury 34.79 11.46 564 754517 46058 89827308
Vein rupture 34.73 11.46 55 755026 1606 89871760
Fistula repair 34.58 11.46 14 755067 40 89873326
Respiratory distress 34.44 11.46 187 754894 38759 89834607
Small intestinal stenosis 34.34 11.46 36 755045 688 89872678
Bronchitis bacterial 34.31 11.46 42 755039 957 89872409
Panic attack 34.29 11.46 109 754972 26256 89847110
Arthritis enteropathic 34.26 11.46 28 755053 383 89872983
Tension headache 34.23 11.46 10 755071 7499 89865867
Ear injury 34.20 11.46 26 755055 318 89873048
Erythema multiforme 34.10 11.46 31 755050 12215 89861151
Clonus 33.98 11.46 4 755077 5746 89867620
Apnoea 33.94 11.46 18 755063 9396 89863970
Large intestinal ulcer 33.94 11.46 90 754991 3827 89869539
Presyncope 33.79 11.46 143 754938 31662 89841704
Respiratory syncytial virus infection 33.64 11.46 23 755058 10457 89862909
Lipase increased 33.56 11.46 26 755055 11085 89862281
Meningitis tuberculous 33.53 11.46 34 755047 624 89872742
Product physical issue 33.29 11.46 4 755077 5656 89867710
Bradyphrenia 33.15 11.46 11 755070 7601 89865765
Joint effusion 33.10 11.46 279 754802 19431 89853935
End stage renal disease 33.01 11.46 15 755066 8556 89864810
Wrist surgery 32.89 11.46 40 755041 905 89872461
Influenza like illness 32.81 11.46 473 754608 80138 89793228
Sleep disorder due to a general medical condition 32.68 11.46 228 754853 44510 89828856
Candida infection 32.67 11.46 159 754922 33898 89839468
Pathological fracture 32.64 11.46 20 755061 9640 89863726
Sports injury 32.57 11.46 12 755069 24 89873342
Electrocardiogram abnormal 32.52 11.46 23 755058 10275 89863091
Cholecystitis acute 32.43 11.46 19 755062 9385 89863981
Hepatomegaly 32.29 11.46 38 755043 13288 89860078
Aplasia pure red cell 32.27 11.46 3 755078 5191 89868175
Lower gastrointestinal haemorrhage 32.06 11.46 17 755064 8875 89864491
Retinitis 32.04 11.46 474 754607 37984 89835382
Lung opacity 32.02 11.46 6 755075 6096 89867270
Oral mucosal blistering 31.97 11.46 9 755072 6915 89866451
Hypertonia 31.97 11.46 3 755078 5152 89868214
Stupor 31.93 11.46 4 755077 5478 89867888
Aortic arteriosclerosis 31.93 11.46 12 755069 7672 89865694
Torus fracture 31.85 11.46 19 755062 150 89873216
Graft versus host disease 31.76 11.46 14 755067 8130 89865236
Stoma creation 31.72 11.46 18 755063 128 89873238
Hypertriglyceridaemia 31.66 11.46 13 755068 7876 89865490
Blood thyroid stimulating hormone decreased 31.53 11.46 5 755076 5735 89867631
Incorrect dose administered by device 31.51 11.46 5 755076 5732 89867634
T-cell lymphoma 31.46 11.46 36 755045 762 89872604
Low density lipoprotein increased 31.37 11.46 14 755067 8071 89865295
Dyslipidaemia 31.36 11.46 23 755058 10084 89863282
Substance abuse 31.36 11.46 4 755077 5402 89867964
Orthopnoea 31.34 11.46 9 755072 6826 89866540
Vaginal abscess 31.33 11.46 30 755051 512 89872854
Oesophagitis 31.31 11.46 60 755021 17189 89856177
Brain natriuretic peptide increased 31.31 11.46 6 755075 5999 89867367
Neoplasm malignant 31.20 11.46 425 754656 33455 89839911
Musculoskeletal pain 31.18 11.46 1735 753346 169516 89703850
Muscle spasms 31.15 11.46 1748 753333 250135 89623231
Lung squamous cell carcinoma recurrent 31.11 11.46 10 755071 10 89873356
Acute respiratory distress syndrome 31.08 11.46 128 754953 28558 89844808
Suspected COVID-19 31.07 11.46 69 755012 2617 89870749
Oral discomfort 31.07 11.46 25 755056 10458 89862908
Major depression 30.93 11.46 23 755058 10012 89863354
Pulmonary haemorrhage 30.89 11.46 14 755067 7999 89865367
Overweight 30.79 11.46 6 755075 5928 89867438
Inflammatory bowel disease 30.74 11.46 104 754977 5067 89868299
Vulval abscess 30.71 11.46 40 755041 972 89872394
Coma scale abnormal 30.69 11.46 5 755076 5621 89867745
Product prescribing issue 30.67 11.46 14 755067 7965 89865401
Ammonia increased 30.66 11.46 3 755078 4983 89868383
Catheter site pain 30.34 11.46 5 755076 5574 89867792
Cholecystitis 30.30 11.46 60 755021 16980 89856386
Left ventricular hypertrophy 30.26 11.46 7 755074 6137 89867229
Blood glucose abnormal 30.24 11.46 21 755060 9471 89863895
Smear cervix abnormal 30.12 11.46 75 755006 3067 89870299
Suffocation feeling 30.11 11.46 51 755030 1577 89871789
Abscess intestinal 30.00 11.46 56 755025 1872 89871494
Wisdom teeth removal 29.99 11.46 34 755047 712 89872654
Crying 29.98 11.46 111 754970 25534 89847832
Catheter site erythema 29.95 11.46 3 755078 4891 89868475
Haemorrhagic diathesis 29.93 11.46 5 755076 5519 89867847
Coccidioidomycosis 29.92 11.46 43 755038 1150 89872216
Foot deformity 29.90 11.46 679 754402 58972 89814394
Device related infection 29.89 11.46 112 754969 25674 89847692
Product administration interrupted 29.86 11.46 36 755045 12456 89860910
Extrapulmonary tuberculosis 29.86 11.46 26 755055 390 89872976
Application site erythema 29.86 11.46 4 755077 5204 89868162
Mean cell volume decreased 29.82 11.46 94 754987 4412 89868954
Hair follicle tumour benign 29.75 11.46 26 755055 392 89872974
Cataract 29.70 11.46 422 754659 71670 89801696
Cervix carcinoma stage 0 29.65 11.46 30 755051 549 89872817
Peritonitis bacterial 29.58 11.46 4 755077 5167 89868199
Blood chloride decreased 29.58 11.46 8 755073 6311 89867055
Snoring 29.24 11.46 4 755077 5122 89868244
Lower limb fracture 29.18 11.46 921 754160 84092 89789274
Cutaneous T-cell lymphoma 28.98 11.46 50 755031 1570 89871796
Cardiac failure chronic 28.69 11.46 6 755075 5640 89867726
Intermenstrual bleeding 28.60 11.46 21 755060 9202 89864164
Limb injury 28.57 11.46 150 754931 31358 89842008
Mycobacterium avium complex infection 28.52 11.46 87 754994 4011 89869355
Intestinal tuberculosis 28.52 11.46 16 755065 111 89873255
Visual impairment 28.49 11.46 862 754219 131503 89741863
Central nervous system lesion 28.44 11.46 33 755048 11613 89861753
Musculoskeletal disorder 28.43 11.46 292 754789 21477 89851889
Laboratory test abnormal 28.32 11.46 218 754863 41636 89831730
Influenza 28.26 11.46 914 754167 138350 89735016
Spinal osteoarthritis 27.93 11.46 75 755006 19073 89854293
Serum ferritin decreased 27.85 11.46 65 755016 2549 89870817
Eye swelling 27.72 11.46 138 754943 29248 89844118
Dermatitis bullous 27.69 11.46 27 755054 10289 89863077
Neutrophilia 27.64 11.46 7 755074 5771 89867595
Night sweats 27.60 11.46 1325 753756 127441 89745925
Eructation 27.49 11.46 30 755051 10852 89862514
C-reactive protein 27.48 11.46 390 754691 30977 89842389
Patent ductus arteriosus 27.45 11.46 3 755078 4566 89868800
Injection site irritation 27.44 11.46 8 755073 6007 89867359
Vulval disorder 27.41 11.46 44 755037 1300 89872066
Acute graft versus host disease 27.40 11.46 6 755075 5462 89867904
Cutaneous lupus erythematosus 27.38 11.46 72 755009 3046 89870320
Pruritus genital 27.36 11.46 3 755078 4555 89868811
Metabolic disorder 27.35 11.46 14 755067 7456 89865910
Scleroderma 27.35 11.46 9 755072 6252 89867114
Infected fistula 27.32 11.46 20 755061 230 89873136
Hypersomnia 27.32 11.46 90 754991 21441 89851925
Lower respiratory tract infection viral 27.31 11.46 37 755044 935 89872431
Lung neoplasm malignant 27.28 11.46 316 754765 23957 89849409
Drooling 27.27 11.46 3 755078 4543 89868823
Skin abrasion 27.26 11.46 32 755049 11203 89862163
Non-cardiac chest pain 27.10 11.46 11 755070 6710 89866656
COVID-19 27.02 11.46 1691 753390 167152 89706214
Euphoric mood 26.97 11.46 6 755075 5403 89867963
Haemolysis 26.88 11.46 19 755062 8491 89864875
Sexual dysfunction 26.81 11.46 4 755077 4800 89868566
Anal fistula infection 26.78 11.46 11 755070 33 89873333
Investigation abnormal 26.74 11.46 59 755022 2228 89871138
Dysphoria 26.62 11.46 9 755072 6145 89867221
Atrioventricular block second degree 26.55 11.46 3 755078 4449 89868917
Atrial septal defect 26.52 11.46 18 755063 8216 89865150
Mycobacterium chelonae infection 26.51 11.46 30 755051 627 89872739
Muscle strain 26.41 11.46 25 755056 9662 89863704
Enterocolitis 26.41 11.46 29 755052 10461 89862905
Gastrointestinal scarring 26.23 11.46 25 755056 424 89872942
International normalised ratio decreased 26.21 11.46 4 755077 4720 89868646
Brain injury 26.17 11.46 16 755065 7722 89865644
Lupus vulgaris 26.16 11.46 524 754557 44535 89828831
Depressive symptom 26.08 11.46 6 755075 5279 89868087
Cellulitis 26.00 11.46 571 754510 90766 89782600
Drug resistance 25.94 11.46 148 754933 30301 89843065
Epstein-Barr virus associated lymphoproliferative disorder 25.93 11.46 64 755017 2603 89870763
Foetal growth restriction 25.82 11.46 24 755057 9356 89864010
Omphalitis 25.78 11.46 17 755064 163 89873203
Therapy change 25.74 11.46 19 755062 8303 89865063
Spinal compression fracture 25.67 11.46 55 755026 15123 89858243
Haemorrhagic stroke 25.60 11.46 11 755070 6485 89866881
Metastases to lymph nodes 25.56 11.46 36 755045 11653 89861713
Growth retardation 25.54 11.46 50 755031 1733 89871633
Blood phosphorus increased 25.52 11.46 3 755078 4315 89869051
Atrial tachycardia 25.49 11.46 9 755072 5981 89867385
Thoracic vertebral fracture 25.49 11.46 7 755074 5467 89867899
Peripheral arterial occlusive disease 25.44 11.46 4 755077 4617 89868749
Bundle branch block right 25.34 11.46 7 755074 5446 89867920
Renal cyst 25.34 11.46 43 755038 12907 89860459
Cerebral haematoma 25.30 11.46 3 755078 4286 89869080
Soft tissue disorder 25.25 11.46 86 754995 4204 89869162
Viral infection 25.15 11.46 222 754859 41192 89832174
Myocardial ischaemia 25.12 11.46 48 755033 13766 89859600
Dizziness postural 25.11 11.46 23 755058 9030 89864336
Pericarditis tuberculous 25.10 11.46 9 755072 16 89873350
Vitreous floaters 25.00 11.46 16 755065 7533 89865833
Femoral neck fracture 24.99 11.46 29 755052 10204 89863162
Legionella infection 24.97 11.46 26 755055 493 89872873
Autoimmune haemolytic anaemia 24.86 11.46 8 755073 5637 89867729
Polydipsia 24.86 11.46 3 755078 4228 89869138
Tuberculosis liver 24.76 11.46 9 755072 17 89873349
Increased tendency to bruise 24.66 11.46 38 755043 11852 89861514
Loss of consciousness 24.63 11.46 937 754144 139301 89734065
Ventricular hypokinesia 24.55 11.46 7 755074 5334 89868032
Foot fracture 24.50 11.46 126 754955 26480 89846886
Pulmonary function test decreased 24.50 11.46 4 755077 4490 89868876
Pathogen resistance 24.50 11.46 19 755062 8096 89865270
Anti-cyclic citrullinated peptide antibody 24.47 11.46 340 754741 26881 89846485
Systemic infection 24.41 11.46 5 755076 4770 89868596
Nail operation 24.39 11.46 51 755030 1855 89871511
Brachiocephalic artery stenosis 24.35 11.46 10 755071 30 89873336
Escherichia urinary tract infection 24.26 11.46 49 755032 13766 89859600
Ocular sarcoidosis 24.18 11.46 13 755068 82 89873284
Cerebral ischaemia 24.17 11.46 15 755066 7181 89866185
Chronic graft versus host disease 24.16 11.46 3 755078 4136 89869230
Bartholin's cyst 24.10 11.46 7 755074 3 89873363
Skin atrophy 24.06 11.46 8 755073 5521 89867845
Scratch 24.05 11.46 28 755053 9838 89863528
Blood immunoglobulin E increased 23.98 11.46 4 755077 4421 89868945
Adverse reaction 23.90 11.46 364 754717 29348 89844018
Nasal congestion 23.88 11.46 521 754560 82893 89790473
Left ventricular failure 23.88 11.46 13 755068 6687 89866679
Guttate psoriasis 23.87 11.46 27 755054 564 89872802
Stoma closure 23.85 11.46 17 755064 187 89873179
Congestive cardiomyopathy 23.79 11.46 16 755065 7338 89866028
Product dispensing error 23.79 11.46 41 755040 12232 89861134
Urine analysis abnormal 23.71 11.46 7 755074 5214 89868152
Tooth loss 23.69 11.46 17 755064 7537 89865829
Hypoxic-ischaemic encephalopathy 23.64 11.46 5 755076 4663 89868703
Respiration abnormal 23.59 11.46 19 755062 7944 89865422
Haemoglobin abnormal 23.57 11.46 15 755066 7085 89866281
Drain placement 23.55 11.46 13 755068 87 89873279
Blood urine present 23.49 11.46 70 755011 17208 89856158
Faecal volume decreased 23.42 11.46 19 755062 257 89873109
Splenomegaly 23.42 11.46 45 755036 12879 89860487
Myocarditis 23.37 11.46 50 755031 13756 89859610
Bone tuberculosis 23.30 11.46 20 755061 294 89873072
Anastomotic ulcer 23.25 11.46 27 755054 581 89872785
Lupus vasculitis 23.25 11.46 27 755054 581 89872785
Methaemoglobinaemia 23.22 11.46 3 755078 4012 89869354
Ventricular arrhythmia 23.21 11.46 4 755077 4317 89869049
Maternal exposure timing unspecified 23.21 11.46 288 754793 22195 89851171
Small intestine carcinoma 23.19 11.46 25 755056 494 89872872
Clostridium difficile colitis 23.19 11.46 129 754952 26577 89846789
Arteriosclerosis 23.17 11.46 34 755047 10819 89862547
Intracranial pressure increased 23.15 11.46 14 755067 6797 89866569
Skin fissures 23.08 11.46 92 754989 20717 89852649
Pseudomonal sepsis 23.07 11.46 4 755077 4298 89869068
Rheumatoid lung 23.06 11.46 81 755000 4022 89869344
Carotid artery occlusion 23.05 11.46 12 755069 6330 89867036
Intestinal ischaemia 22.98 11.46 24 755057 8859 89864507
Faecaloma 22.94 11.46 32 755049 10399 89862967
Lung consolidation 22.90 11.46 6 755075 4834 89868532
Nerve compression 22.66 11.46 33 755048 10533 89862833
Failure to thrive 22.59 11.46 22 755059 8389 89864977
Nasal discomfort 22.50 11.46 9 755072 5539 89867827
Proctitis ulcerative 22.49 11.46 20 755061 309 89873057
Hypoventilation 22.47 11.46 8 755073 5288 89868078
Obsessive-compulsive disorder 22.45 11.46 5 755076 4499 89868867
Chest discomfort 22.36 11.46 1387 753694 136978 89736388
Incorrect product administration duration 22.35 11.46 84 754997 19238 89854128
Rectal discharge 22.35 11.46 32 755049 853 89872513
Supraventricular extrasystoles 22.20 11.46 8 755073 5249 89868117
Hypovolaemic shock 22.20 11.46 16 755065 7078 89866288
Joint dislocation 22.19 11.46 507 754574 44075 89829291
Appetite disorder 22.17 11.46 26 755055 9107 89864259
Drug effective for unapproved indication 22.16 11.46 127 754954 7791 89865575
Musculoskeletal chest pain 22.14 11.46 112 754969 23638 89849728
Cerebellar syndrome 22.14 11.46 3 755078 3869 89869497
Bowen's disease 22.09 11.46 17 755064 212 89873154
Skin hyperpigmentation 22.04 11.46 15 755066 6836 89866530
Deafness neurosensory 21.97 11.46 15 755066 6826 89866540
Pyoderma 21.96 11.46 25 755056 526 89872840
International normalised ratio abnormal 21.93 11.46 3 755078 3842 89869524
Portal hypertension 21.91 11.46 6 755075 4695 89868671
Catheterisation cardiac 21.87 11.46 7 755074 4949 89868417
Lumbar vertebral fracture 21.84 11.46 18 755063 7440 89865926
Ileostomy closure 21.82 11.46 19 755062 285 89873081
Hair texture abnormal 21.81 11.46 6 755075 4681 89868685
Nervous system disorder 21.78 11.46 99 754982 21494 89851872
Pharyngitis streptococcal 21.74 11.46 181 754900 12561 89860805
Opportunistic infection 21.72 11.46 53 755028 2140 89871226
Galactorrhoea 21.71 11.46 6 755075 4666 89868700
Varicella 21.64 11.46 56 755025 2346 89871020
Ventricular septal defect 21.56 11.46 9 755072 5398 89867968
Tachyarrhythmia 21.55 11.46 9 755072 5397 89867969
Alopecia universalis 21.50 11.46 15 755066 159 89873207
Paronychia 21.43 11.46 21 755060 7985 89865381
Mood swings 21.43 11.46 94 754987 20608 89852758
Duodenal ulcer 21.31 11.46 29 755052 9523 89863843
Increased appetite 21.29 11.46 41 755040 11724 89861642
Bowel movement irregularity 21.28 11.46 109 754972 6405 89866961
Foetal death 21.20 11.46 265 754816 20458 89852908
Loose tooth 21.16 11.46 3 755078 3740 89869626
Gingival graft 21.16 11.46 14 755067 135 89873231
Diabetic eye disease 21.04 11.46 15 755066 165 89873201
Tooth fracture 21.03 11.46 46 755035 12554 89860812
Brain death 21.00 11.46 4 755077 4017 89869349
Anaplastic large-cell lymphoma 20.96 11.46 12 755069 87 89873279
Cachexia 20.89 11.46 16 755065 6862 89866504
Crohn's disease 20.89 11.46 88 754993 4763 89868603
Spondyloarthropathy 20.88 11.46 37 755044 1187 89872179
Muscle tightness 20.87 11.46 51 755030 13388 89859978
Paranasal sinus hypersecretion 20.86 11.46 6 755075 4545 89868821
Performance status decreased 20.84 11.46 5 755076 4275 89869091
Chronic disease 20.83 11.46 16 755065 199 89873167
Fine motor skill dysfunction 20.82 11.46 95 754986 5324 89868042
Pharyngeal paraesthesia 20.81 11.46 66 755015 3108 89870258
Atypical femur fracture 20.73 11.46 14 755067 6407 89866959
Cystitis haemorrhagic 20.69 11.46 10 755071 5503 89867863
Drug dependence 20.67 11.46 151 754930 29176 89844190
Hypermobility syndrome 20.65 11.46 31 755050 863 89872503
Serum sickness-like reaction 20.65 11.46 25 755056 563 89872803
Perineal abscess 20.53 11.46 20 755061 349 89873017
Therapeutic reaction time decreased 20.52 11.46 3 755078 3655 89869711
Hyperaesthesia 20.52 11.46 36 755045 10666 89862700
Areflexia 20.49 11.46 3 755078 3650 89869716
Intestinal sepsis 20.48 11.46 19 755062 311 89873055
Weight fluctuation 20.39 11.46 253 754828 19496 89853870
Faecal calprotectin 20.37 11.46 6 755075 3 89873363
Cytomegalovirus infection 20.29 11.46 323 754758 26279 89847087
Gastrointestinal bacterial overgrowth 20.28 11.46 29 755052 772 89872594
Lupus hepatitis 20.24 11.46 8 755073 21 89873345
Signet-ring cell carcinoma 20.24 11.46 8 755073 21 89873345
Vein collapse 20.24 11.46 35 755046 1101 89872265
Cytomegalovirus gastrointestinal infection 20.21 11.46 21 755060 397 89872969
Pus in stool 20.15 11.46 10 755071 52 89873314
Extrasystoles 20.13 11.46 11 755070 5646 89867720
Residual urine volume increased 20.09 11.46 12 755069 95 89873271
Coronary artery occlusion 20.08 11.46 25 755056 8529 89864837
Cardiac dysfunction 20.07 11.46 3 755078 3594 89869772
Post transplant lymphoproliferative disorder 20.07 11.46 17 755064 6932 89866434
Sinus node dysfunction 20.03 11.46 10 755071 5402 89867964
Tonsillitis streptococcal 20.03 11.46 13 755068 121 89873245
Infusion site haemorrhage 20.02 11.46 10 755071 5401 89867965
Omentoplasty 19.98 11.46 8 755073 22 89873344
Sensitivity to weather change 19.95 11.46 135 754946 8779 89864587
Anosmia 19.92 11.46 32 755049 9816 89863550
Clear cell renal cell carcinoma 19.89 11.46 42 755039 1538 89871828
White blood cells urine positive 19.89 11.46 15 755066 6483 89866883
Granuloma 19.87 11.46 103 754978 6082 89867284
Cardiac pacemaker insertion 19.85 11.46 6 755075 4401 89868965
Peripheral coldness 19.82 11.46 55 755026 13837 89859529
Product administered to patient of inappropriate age 19.79 11.46 7 755074 4646 89868720
Procedural pain 19.75 11.46 180 754901 33180 89840186
Throat clearing 19.73 11.46 4 755077 3843 89869523
Product use complaint 19.59 11.46 3 755078 3530 89869836
Amylase increased 19.58 11.46 18 755063 7054 89866312
Ear infection bacterial 19.57 11.46 16 755065 219 89873147
Bruxism 19.54 11.46 6 755075 4357 89869009
Hypertransaminasaemia 19.50 11.46 67 755014 15758 89857608
Adhesiolysis 19.48 11.46 8 755073 24 89873342
Ileus paralytic 19.43 11.46 9 755072 5076 89868290
Blood glucose fluctuation 19.41 11.46 9 755072 5074 89868292
Urine odour abnormal 19.40 11.46 19 755062 7225 89866141
Intestinal ulcer 19.28 11.46 43 755038 1636 89871730
Anaphylactic reaction 19.26 11.46 903 754178 86621 89786745
Temperature regulation disorder 19.25 11.46 196 754885 14383 89858983
Device defective 19.23 11.46 3 755078 3483 89869883
Varices oesophageal 19.23 11.46 4 755077 3775 89869591
Sluggishness 19.23 11.46 13 755068 5946 89867420
Iritis 19.22 11.46 71 755010 3615 89869751
Rotator cuff syndrome 19.21 11.46 68 755013 15851 89857515
Stenosis 19.20 11.46 49 755032 2035 89871331
Diverticulum intestinal 19.17 11.46 29 755052 9113 89864253
Sensory disturbance 19.16 11.46 65 755016 15348 89858018
Onychoclasis 19.13 11.46 20 755061 7379 89865987
Injection site discomfort 19.11 11.46 13 755068 5927 89867439
Mean cell haemoglobin decreased 19.10 11.46 96 754985 5599 89867767
Disease susceptibility 19.10 11.46 17 755064 263 89873103
Blood phosphorus decreased 19.09 11.46 9 755072 5025 89868341
Drug screen positive 19.07 11.46 4 755077 3753 89869613
Rectal cancer 19.06 11.46 52 755029 2249 89871117
Photopsia 19.03 11.46 9 755072 5015 89868351
Occult blood positive 19.01 11.46 5 755076 4018 89869348
Drug effect less than expected 19.00 11.46 14 755067 6124 89867242
Impetigo 18.99 11.46 41 755040 1525 89871841
Takayasu's arteritis 18.98 11.46 5 755076 0 89873366
Anal dilatation 18.98 11.46 5 755076 0 89873366
Epigastric discomfort 18.97 11.46 21 755060 7547 89865819
Colon cancer 18.96 11.46 156 754925 10788 89862578
Respiratory alkalosis 18.95 11.46 3 755078 3445 89869921
Ecchymosis 18.95 11.46 47 755034 12276 89861090
Cerebral disorder 18.95 11.46 12 755069 5682 89867684
Aortic stenosis 18.92 11.46 15 755066 6321 89867045
Drug specific antibody absent 18.91 11.46 12 755069 107 89873259
Poor quality product administered 18.90 11.46 5 755076 4003 89869363
Somatic symptom disorder 18.90 11.46 3 755078 3438 89869928
Photophobia 18.87 11.46 102 754979 21167 89852199
Blood parathyroid hormone increased 18.87 11.46 3 755078 3434 89869932
Colon dysplasia 18.85 11.46 13 755068 135 89873231
Lip neoplasm malignant stage unspecified 18.79 11.46 8 755073 27 89873339
BK virus infection 18.73 11.46 7 755074 4491 89868875
Conjunctival haemorrhage 18.73 11.46 5 755076 3979 89869387
Disseminated intravascular coagulation 18.72 11.46 104 754977 21434 89851932
Incoherent 18.72 11.46 9 755072 4968 89868398
Catheter site infection 18.70 11.46 12 755069 5642 89867724
Colostomy closure 18.70 11.46 13 755068 137 89873229
Disseminated coccidioidomycosis 18.70 11.46 13 755068 137 89873229
Product distribution issue 18.70 11.46 4 755077 3701 89869665
Pneumothorax 18.67 11.46 89 754992 19078 89854288
Lung cancer metastatic 18.60 11.46 60 755021 2851 89870515
Application site pain 18.59 11.46 8 755073 4712 89868654
Sickle cell anaemia with crisis 18.56 11.46 20 755061 7277 89866089
Wrong technique in device usage process 18.47 11.46 13 755068 5822 89867544
Enteropathic spondylitis 18.41 11.46 9 755072 45 89873321
Gastrointestinal wall thickening 18.41 11.46 49 755032 2088 89871278
Anxiety disorder 18.36 11.46 9 755072 4913 89868453
Large intestine anastomosis 18.36 11.46 8 755073 29 89873337
Pre-existing condition improved 18.35 11.46 30 755051 9139 89864227
Diabetes mellitus 18.34 11.46 406 754675 64469 89808897
Incorrect dosage administered 18.32 11.46 59 755022 2801 89870565
Compression fracture 18.31 11.46 28 755053 8761 89864605
Red blood cell count increased 18.25 11.46 4 755077 3639 89869727
Hodgkin's disease stage II 18.20 11.46 6 755075 7 89873359
Blood creatinine abnormal 18.12 11.46 6 755075 4151 89869215
Fluid intake reduced 18.08 11.46 6 755075 4146 89869220
Embolism venous 18.08 11.46 4 755077 3616 89869750
Spinal operation 18.04 11.46 36 755045 10160 89863206
Ear pruritus 18.03 11.46 18 755063 6785 89866581
Anorectal discomfort 18.02 11.46 61 755020 2973 89870393
Gastrointestinal toxicity 18.01 11.46 32 755049 9435 89863931
Scoliosis 17.96 11.46 29 755052 8878 89864488
Genital cyst 17.95 11.46 9 755072 48 89873318
Enterococcal infection 17.92 11.46 35 755046 9956 89863410
Blood culture positive 17.85 11.46 10 755071 5062 89868304
Glossitis 17.84 11.46 4 755077 3583 89869783
Coronavirus infection 17.84 11.46 12 755069 5503 89867863
Upper respiratory tract infection 17.83 11.46 880 754201 127438 89745928
Intestinal transit time decreased 17.76 11.46 6 755075 8 89873358
Neck deformity 17.67 11.46 49 755032 2140 89871226
Vasculitis necrotising 17.66 11.46 25 755056 659 89872707
Anorectal ulcer 17.66 11.46 9 755072 50 89873316
Platelet count abnormal 17.63 11.46 7 755074 4328 89869038
Skin ulcer 17.58 11.46 544 754537 49531 89823835
Papilloma viral infection 17.57 11.46 43 755038 1739 89871627
Neoplasm recurrence 17.55 11.46 3 755078 3256 89870110
Enterocolonic fistula 17.52 11.46 9 755072 51 89873315
Hydrocephalus 17.48 11.46 15 755066 6079 89867287
Cytomegalovirus colitis 17.47 11.46 65 755016 3321 89870045
Sputum discoloured 17.43 11.46 99 754982 20292 89853074
Bladder disorder 17.43 11.46 40 755041 10732 89862634
Carcinoma in situ of skin 17.39 11.46 15 755066 222 89873144
Breast cancer metastatic 17.36 11.46 66 755015 15066 89858300
Staphylococcal bacteraemia 17.36 11.46 22 755059 7447 89865919
White blood cell count increased 17.28 11.46 427 754654 66814 89806552
Self-medication 17.26 11.46 3 755078 3217 89870149
Non-consummation 17.24 11.46 9 755072 53 89873313
Chills 17.21 11.46 911 754170 131070 89742296
Eosinophil count decreased 17.20 11.46 3 755078 3209 89870157
Circumstance or information capable of leading to medication error 17.18 11.46 10 755071 4957 89868409
Renal tubular disorder 17.16 11.46 3 755078 3204 89870162
Electrocardiogram ST segment elevation 17.15 11.46 6 755075 4010 89869356
Food allergy 17.10 11.46 303 754778 25175 89848191
Nodule 17.08 11.46 315 754766 26371 89846995
Post procedural inflammation 17.06 11.46 12 755069 129 89873237
C-reactive protein decreased 17.03 11.46 32 755049 1075 89872291
Pneumonia cryptococcal 17.01 11.46 34 755047 1197 89872169
Blood sodium increased 16.98 11.46 3 755078 3179 89870187
Skin swelling 16.97 11.46 18 755063 6596 89866770
Finger deformity 16.97 11.46 376 754705 32521 89840845
Retching 16.93 11.46 92 754989 19067 89854299
Ocular icterus 16.90 11.46 6 755075 3974 89869392
Autonomic nervous system imbalance 16.86 11.46 4 755077 3446 89869920
Klebsiella infection 16.85 11.46 38 755043 10259 89863107
Endophthalmitis 16.83 11.46 9 755072 4676 89868690
Female genital tract fistula 16.81 11.46 225 754856 17643 89855723
Feeling cold 16.78 11.46 147 754934 27318 89846048
Mastitis 16.75 11.46 59 755022 2934 89870432
Brain herniation 16.73 11.46 7 755074 4193 89869173
Hepatic cyst 16.71 11.46 18 755063 6550 89866816
Hunger 16.68 11.46 18 755063 6545 89866821
Vulval neoplasm 16.66 11.46 5 755076 3 89873363
Tonsillar neoplasm 16.66 11.46 5 755076 3 89873363
Stricturoplasty 16.66 11.46 5 755076 3 89873363
Acute pulmonary histoplasmosis 16.61 11.46 12 755069 135 89873231
Enuresis 16.60 11.46 4 755077 3410 89869956
Varicose vein 16.59 11.46 22 755059 7305 89866061
Product substitution 16.58 11.46 9 755072 58 89873308
Interstitial lung disease 16.58 11.46 497 754584 75908 89797458
Steroid dependence 16.57 11.46 49 755032 2220 89871146
Blood magnesium increased 16.56 11.46 4 755077 3404 89869962
Short stature 16.55 11.46 31 755050 1039 89872327
Plasmablastic lymphoma 16.54 11.46 15 755066 238 89873128
Exostosis 16.53 11.46 569 754512 52565 89820801
Complications of bone marrow transplant 16.50 11.46 20 755061 451 89872915
Ischaemia 16.49 11.46 12 755069 5283 89868083
Pyrexia 16.48 11.46 5084 749997 655401 89217965
Gastrointestinal stenosis 16.48 11.46 16 755065 278 89873088
Meniscus injury 16.44 11.46 27 755054 8210 89865156
Vitamin B12 deficiency 16.43 11.46 23 755058 7463 89865903
Neck mass 16.39 11.46 70 755011 3812 89869554
Micturition urgency 16.38 11.46 44 755037 11189 89862177
Laryngeal disorder 16.31 11.46 32 755049 1111 89872255
Perirectal abscess 16.29 11.46 29 755052 934 89872432
Bronchiectasis 16.21 11.46 114 754967 22216 89851150
Thrombosis in device 16.19 11.46 3 755078 3072 89870294
Oral pain 16.18 11.46 184 754897 32499 89840867
Muscle haemorrhage 16.11 11.46 4 755077 3342 89870024
Hodgkin's disease mixed cellularity stage unspecified 16.08 11.46 5 755076 4 89873362
Dyspnoea at rest 16.08 11.46 10 755071 4781 89868585
Pulse absent 16.08 11.46 16 755065 6039 89867327
Endometriosis 16.06 11.46 98 754983 6150 89867216
Hyperparathyroidism 16.05 11.46 4 755077 3333 89870033
Intestinal dilatation 16.04 11.46 49 755032 2261 89871105
Electroencephalogram abnormal 16.04 11.46 7 755074 4089 89869277
Ankle deformity 15.99 11.46 20 755061 466 89872900
Hepatic necrosis 15.99 11.46 18 755063 6420 89866946
Fistula inflammation 15.97 11.46 6 755075 13 89873353
Escherichia infection 15.95 11.46 73 755008 15822 89857544
Product monitoring error 15.93 11.46 9 755072 4535 89868831
Ligament sprain 15.91 11.46 65 755016 14534 89858832
Product preparation error 15.88 11.46 39 755042 10222 89863144
Embolic stroke 15.88 11.46 7 755074 4065 89869301
Paraesthesia 15.87 11.46 1834 753247 248492 89624874
Pemphigoid 15.86 11.46 32 755049 8994 89864372
Breast pain 15.81 11.46 40 755041 10378 89862988
Lumbar spinal stenosis 15.79 11.46 14 755067 5583 89867783
Craniocerebral injury 15.77 11.46 4 755077 3294 89870072
Ectopic pregnancy 15.72 11.46 61 755020 3180 89870186
Sleep disorder 15.64 11.46 1882 753199 196148 89677218
Joint tuberculosis 15.64 11.46 12 755069 149 89873217
Thermal burn 15.63 11.46 20 755061 6742 89866624
Peritonitis 15.61 11.46 98 754983 19607 89853759
Blood immunoglobulin G decreased 15.61 11.46 5 755076 3533 89869833
Anal ulcer 15.60 11.46 26 755055 793 89872573
Rash morbilliform 15.60 11.46 7 755074 4022 89869344
Retinopathy 15.58 11.46 5 755076 3529 89869837
Spleen tuberculosis 15.56 11.46 5 755076 5 89873361
Communication disorder 15.54 11.46 4 755077 3262 89870104
Carbohydrate antigen 125 increased 15.54 11.46 4 755077 3262 89870104
Viral pericarditis 15.54 11.46 7 755074 28 89873338
Skin induration 15.51 11.46 4 755077 3258 89870108
Pulmonary toxicity 15.47 11.46 47 755034 11484 89861882
Muscle atrophy 15.44 11.46 29 755052 8372 89864994
Precancerous cells present 15.40 11.46 38 755043 1545 89871821
Cutaneous tuberculosis 15.37 11.46 13 755068 187 89873179
Proctalgia 15.37 11.46 119 754962 8079 89865287
Haemarthrosis 15.36 11.46 7 755074 3987 89869379
Gastric disorder 15.36 11.46 191 754890 33193 89840173
Aplasia 15.35 11.46 7 755074 3984 89869382
Salpingectomy 15.30 11.46 18 755063 393 89872973
Bedridden 15.26 11.46 51 755030 12097 89861269
Vitamin D decreased 15.25 11.46 50 755031 11929 89861437
Joint noise 15.20 11.46 13 755068 5277 89868089
Facial paralysis 15.20 11.46 72 755009 15462 89857904
Body temperature decreased 15.20 11.46 281 754800 23535 89849831
General symptom 15.19 11.46 188 754893 14480 89858886
Sydenham's chorea 15.18 11.46 4 755077 0 89873366
Otitis externa bacterial 15.18 11.46 4 755077 0 89873366
Atypical mycobacterial lymphadenitis 15.18 11.46 4 755077 0 89873366
Malignant melanoma of sites other than skin 15.18 11.46 4 755077 0 89873366
Drain site complication 15.18 11.46 4 755077 0 89873366
Chronic granulomatous disease 15.18 11.46 4 755077 0 89873366
Facial paresis 15.16 11.46 7 755074 3956 89869410
Pelvic pain 15.14 11.46 71 755010 15286 89858080
Feeling of despair 15.10 11.46 4 755077 3200 89870166
Fear of injection 15.09 11.46 122 754959 8393 89864973
Rebound effect 15.06 11.46 35 755046 9349 89864017
Tenderness 15.04 11.46 147 754934 26721 89846645
Angioimmunoblastic T-cell lymphoma 15.00 11.46 14 755067 231 89873135
Pneumatosis intestinalis 14.91 11.46 5 755076 3432 89869934
Cerebral atrophy 14.90 11.46 15 755066 5631 89867735
Aortic valve incompetence 14.89 11.46 20 755061 6604 89866762
Scleritis 14.88 11.46 84 754997 5124 89868242
Neurogenic bladder 14.86 11.46 6 755075 3672 89869694
Gastrointestinal carcinoma 14.86 11.46 47 755034 2210 89871156
Diffuse large B-cell lymphoma 14.85 11.46 123 754958 8522 89864844
Thyroid disorder 14.85 11.46 87 754994 17698 89855668
Distributive shock 14.82 11.46 5 755076 3419 89869947
Superficial spreading melanoma stage unspecified 14.81 11.46 12 755069 162 89873204
Duodenitis 14.79 11.46 9 755072 4354 89869012
Metastatic malignant melanoma 14.77 11.46 38 755043 1586 89871780
Multiple system atrophy 14.77 11.46 13 755068 198 89873168
Lip blister 14.74 11.46 3 755078 2875 89870491
Oral disorder 14.73 11.46 41 755040 10304 89863062
Nephrotic syndrome 14.70 11.46 24 755057 7315 89866051
Staphylococcus test positive 14.68 11.46 9 755072 4336 89869030
Joint stiffness 14.66 11.46 793 754288 77249 89796117
Abortion incomplete 14.65 11.46 4 755077 3136 89870230
Small intestine operation 14.65 11.46 7 755074 33 89873333
Pulmonary alveolar haemorrhage 14.64 11.46 17 755064 5981 89867385
Pelvic abscess 14.61 11.46 44 755037 2014 89871352
Gastrointestinal perforation 14.59 11.46 9 755072 4323 89869043
Anastomotic complication 14.57 11.46 16 755065 323 89873043
Acute coronary syndrome 14.56 11.46 44 755037 10769 89862597
Hyperpyrexia 14.56 11.46 11 755070 4750 89868616
Gastrointestinal mucosa hyperaemia 14.56 11.46 13 755068 202 89873164
Feeling drunk 14.54 11.46 11 755070 4747 89868619
Procedural haemorrhage 14.54 11.46 4 755077 3120 89870246
Obstruction 14.52 11.46 68 755013 3853 89869513
Impaired gastric emptying 14.50 11.46 167 754914 12642 89860724
Blood bicarbonate decreased 14.50 11.46 4 755077 3115 89870251
Blood pressure diastolic increased 14.49 11.46 168 754913 12738 89860628
Petit mal epilepsy 14.48 11.46 12 755069 4946 89868420
Arteriosclerosis coronary artery 14.48 11.46 37 755044 9566 89863800
Coronary arterial stent insertion 14.47 11.46 3 755078 2837 89870529
Drug eruption 14.45 11.46 392 754689 35015 89838351
Feeding disorder 14.45 11.46 86 754995 17426 89855940
Jaw disorder 14.41 11.46 15 755066 5544 89867822
Squamous cell carcinoma of the vagina 14.37 11.46 6 755075 19 89873347
Pneumocystis jirovecii infection 14.32 11.46 42 755039 1894 89871472
International normalised ratio fluctuation 14.32 11.46 4 755077 3089 89870277
Necrotising fasciitis streptococcal 14.32 11.46 8 755073 55 89873311
Proctitis 14.29 11.46 192 754889 15067 89858299
Cytomegalovirus infection reactivation 14.27 11.46 27 755054 7773 89865593
Abdominal pain upper 14.24 11.46 2496 752585 330178 89543188
Laryngitis 14.19 11.46 537 754544 50216 89823150
Vitamin B12 decreased 14.13 11.46 14 755067 5296 89868070
Gastrointestinal fistula 14.08 11.46 20 755061 529 89872837
Intercepted product prescribing error 14.05 11.46 15 755066 293 89873073
Osteolysis 14.01 11.46 6 755075 3544 89869822
Angle closure glaucoma 13.99 11.46 3 755078 2772 89870594
Viral tonsillitis 13.91 11.46 5 755076 9 89873357
Coronary artery stenosis 13.88 11.46 14 755067 5252 89868114
Hyperaemia 13.87 11.46 51 755030 2591 89870775
Polycystic ovaries 13.83 11.46 16 755065 5638 89867728
Swelling of eyelid 13.82 11.46 15 755066 5439 89867927
Shoulder arthroplasty 13.81 11.46 70 755011 4096 89869270
Chronic respiratory failure 13.75 11.46 3 755078 2738 89870628
Joint injury 13.72 11.46 363 754718 32301 89841065
Faecal calprotectin decreased 13.72 11.46 7 755074 39 89873327
Anorectal operation 13.72 11.46 6 755075 22 89873344
Logorrhoea 13.65 11.46 3 755078 2724 89870642
Mean cell volume increased 13.64 11.46 13 755068 5008 89868358
Walking aid user 13.62 11.46 390 754691 35116 89838250
Cardiac myxoma 13.62 11.46 15 755066 304 89873062
Pregnancy 13.61 11.46 640 754441 61407 89811959
Product supply issue 13.61 11.46 4 755077 2988 89870378
Gingival swelling 13.59 11.46 13 755068 5000 89868366
Oropharyngeal cancer 13.58 11.46 7 755074 40 89873326
Endometrial neoplasm 13.57 11.46 5 755076 10 89873356
Eosinophilic pleural effusion 13.55 11.46 11 755070 149 89873217
Neoplasm skin 13.53 11.46 57 755024 3085 89870281
Pelvic fracture 13.49 11.46 73 755008 15146 89858220
Protein total decreased 13.45 11.46 24 755057 7065 89866301
Neuroendocrine carcinoma of the skin 13.45 11.46 25 755056 833 89872533
Mouth ulceration 13.44 11.46 432 754649 39542 89833824
Chloropsia 13.43 11.46 8 755073 63 89873303
Polymyalgia rheumatica 13.39 11.46 13 755068 4964 89868402
Sacroiliitis 13.37 11.46 70 755011 4149 89869217
Injection site hypersensitivity 13.36 11.46 3 755078 2684 89870682
Stomal hernia 13.35 11.46 15 755066 311 89873055
Dysgraphia 13.34 11.46 7 755074 3676 89869690
Nerve block 13.30 11.46 25 755056 840 89872526
Eczema infected 13.25 11.46 11 755070 154 89873212
Ileal perforation 13.20 11.46 19 755062 509 89872857
Osteosclerosis 13.19 11.46 10 755071 4310 89869056
Creatinine urine abnormal 13.17 11.46 7 755074 43 89873323
Muscle contractions involuntary 13.16 11.46 4 755077 2924 89870442
Sinus headache 13.14 11.46 21 755060 6455 89866911
Laryngeal cancer 13.14 11.46 11 755070 156 89873210
Serum ferritin increased 13.11 11.46 26 755055 7355 89866011
Rectal cancer metastatic 13.01 11.46 14 755067 276 89873090
Madarosis 12.99 11.46 7 755074 3622 89869744
Cytomegalovirus mononucleosis 12.97 11.46 4 755077 3 89873363
Respiratory tract carcinoma in situ 12.97 11.46 4 755077 3 89873363
Vascular procedure complication 12.97 11.46 4 755077 3 89873363
Gingival bleeding 12.93 11.46 72 755009 14831 89858535
Diffuse large B-cell lymphoma stage II 12.92 11.46 8 755073 68 89873298
Limb operation 12.92 11.46 73 755008 4454 89868912
Blood cholesterol abnormal 12.90 11.46 4 755077 2886 89870480
Skin erosion 12.90 11.46 6 755075 3376 89869990
Granulomatous liver disease 12.86 11.46 26 755055 923 89872443
Angina unstable 12.83 11.46 25 755056 7118 89866248
Culture urine positive 12.81 11.46 8 755073 3817 89869549
Growth failure 12.79 11.46 16 755065 373 89872993
Orbital apex syndrome 12.79 11.46 7 755074 46 89873320
Pleural fibrosis 12.78 11.46 7 755074 3589 89869777
Meningitis coccidioides 12.77 11.46 6 755075 27 89873339
Oesophageal spasm 12.76 11.46 6 755075 3355 89870011
Odynophagia 12.76 11.46 36 755045 9007 89864359
Paranasal sinus discomfort 12.73 11.46 20 755061 6190 89867176
Toothache 12.70 11.46 121 754960 22109 89851257
Fistulotomy 12.68 11.46 5 755076 13 89873353
Monocyte count decreased 12.67 11.46 3 755078 2588 89870778
Tetany 12.62 11.46 3 755078 2581 89870785
Herpes ophthalmic 12.61 11.46 34 755047 1460 89871906
Mitral valve disease 12.60 11.46 3 755078 2579 89870787
Nasopharyngeal cancer 12.60 11.46 6 755075 28 89873338
Flank pain 12.59 11.46 101 754980 19121 89854245
Therapy partial responder 12.59 11.46 120 754961 21923 89851443
Subcutaneous drug absorption impaired 12.51 11.46 170 754911 13375 89859991
Retroperitoneal haemorrhage 12.48 11.46 5 755076 3075 89870291
Disease complication 12.48 11.46 8 755073 3764 89869602
Bicytopenia 12.48 11.46 8 755073 3763 89869603
Hodgkin's disease nodular sclerosis 12.45 11.46 4 755077 4 89873362
Drain removal 12.45 11.46 4 755077 4 89873362
Blood pH decreased 12.43 11.46 3 755078 2555 89870811
Abscess bacterial 12.42 11.46 13 755068 248 89873118
Kounis syndrome 12.40 11.46 3 755078 2550 89870816
Quadriparesis 12.37 11.46 3 755078 2546 89870820
Foot operation 12.36 11.46 122 754959 8879 89864487
Ophthalmic herpes zoster 12.34 11.46 51 755030 2737 89870629
Pupillary reflex impaired 12.34 11.46 3 755078 2542 89870824
Hepatic cirrhosis 12.33 11.46 645 754436 62608 89810758
Infrequent bowel movements 12.33 11.46 34 755047 1480 89871886
Essential hypertension 12.33 11.46 21 755060 6294 89867072
Antibody test abnormal 12.32 11.46 23 755058 769 89872597
Uterine carcinoma in situ 12.28 11.46 6 755075 30 89873336
Erythema of eyelid 12.25 11.46 6 755075 3277 89870089
Eye infection bacterial 12.25 11.46 14 755067 296 89873070
Diabetic neuropathy 12.24 11.46 12 755069 4562 89868804
Conjunctivitis 12.21 11.46 153 754928 26553 89846813
Lung neoplasm 12.21 11.46 97 754984 6638 89866728
Intestinal mucosal atrophy 12.17 11.46 5 755076 15 89873351
Systemic candida 12.17 11.46 14 755067 4945 89868421
Myasthenia gravis 12.16 11.46 24 755057 6801 89866565
Thyroidectomy 12.14 11.46 31 755050 1288 89872078
Extranodal marginal zone B-cell lymphoma (MALT type) 12.12 11.46 19 755062 550 89872816
Gastrointestinal stoma complication 12.12 11.46 46 755035 2373 89870993
Uterine haemorrhage 12.12 11.46 13 755068 4739 89868627
Musculoskeletal discomfort 12.11 11.46 114 754967 20877 89852489
Capillary leak syndrome 12.05 11.46 4 755077 2763 89870603
Tongue disorder 12.03 11.46 141 754940 10719 89862647
Axial spondyloarthritis 11.98 11.46 20 755061 611 89872755
Bladder repair 11.98 11.46 9 755072 108 89873258
Gastric ulcer haemorrhage 11.97 11.46 16 755065 5295 89868071
Wrong product administered 11.97 11.46 29 755052 7636 89865730
Mean cell haemoglobin increased 11.97 11.46 9 755072 3896 89869470
Squamous cell carcinoma of lung 11.95 11.46 27 755054 1036 89872330
Ejection fraction abnormal 11.95 11.46 3 755078 2488 89870878
Pulmonary pain 11.95 11.46 15 755066 5099 89868267
Papule 11.93 11.46 31 755050 7971 89865395
Electrocardiogram T wave inversion 11.93 11.46 8 755073 3675 89869691
Liver function test abnormal 11.92 11.46 528 754553 50317 89823049
Blood potassium abnormal 11.91 11.46 5 755076 2989 89870377
Macular oedema 11.89 11.46 14 755067 4895 89868471
Ear pain 11.87 11.46 378 754703 57324 89816042
Glucose tolerance impaired 11.86 11.46 31 755050 7954 89865412
Cutaneous leishmaniasis 11.84 11.46 9 755072 110 89873256
Endocarditis 11.84 11.46 26 755055 7087 89866279
Mouth swelling 11.83 11.46 18 755063 5644 89867722
Tuberculosis of eye 11.82 11.46 6 755075 33 89873333
Rhonchi 11.80 11.46 5 755076 2973 89870393
Product residue present 11.79 11.46 11 755070 4280 89869086
Fibrin D dimer increased 11.76 11.46 17 755064 5443 89867923
Tongue oedema 11.73 11.46 17 755064 5437 89867929
Wrist fracture 11.72 11.46 79 755002 15545 89857821
Ocular discomfort 11.70 11.46 22 755059 6348 89867018
Hyperventilation 11.70 11.46 24 755057 6704 89866662
Biliary colic 11.66 11.46 10 755071 4053 89869313
Generalised oedema 11.63 11.46 102 754979 18951 89854415
Blood pressure systolic decreased 11.59 11.46 39 755042 9231 89864135
Respiratory symptom 11.56 11.46 11 755070 4241 89869125
Eyelid oedema 11.56 11.46 53 755028 11481 89861885
Oesophageal stenosis 11.56 11.46 9 755072 3827 89869539
Paraparesis 11.54 11.46 5 755076 2933 89870433
Neck injury 11.53 11.46 3 755078 2429 89870937
Electrocardiogram T wave abnormal 11.51 11.46 4 755077 2684 89870682
Malignant anorectal neoplasm 11.50 11.46 5 755076 18 89873348
Large intestine operation 11.50 11.46 5 755076 18 89873348
Chest pain 11.49 11.46 2420 752661 317225 89556141
Mucormycosis 11.47 11.46 9 755072 3812 89869554

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 5775.87 12.43 11269 215710 627066 41767290
Intentional product use issue 5080.32 12.43 3690 223289 68143 42326213
Infusion related reaction 4483.96 12.43 3205 223774 57601 42336755
Inappropriate schedule of product administration 2976.05 12.43 3078 223901 92824 42301532
Product use issue 2631.74 12.43 2601 224378 74150 42320206
Condition aggravated 2420.07 12.43 4681 222298 256073 42138283
Blood pressure fluctuation 1607.81 12.43 1252 225727 25656 42368700
Drug ineffective 1232.91 12.43 6585 220394 623612 41770744
Drug level below therapeutic 1206.06 12.43 622 226357 5923 42388433
Weight increased 1180.69 12.43 2085 224894 105898 42288458
Haematochezia 1175.08 12.43 1501 225478 56935 42337421
Intestinal resection 1166.96 12.43 421 226558 1443 42392913
Fistula 1144.10 12.43 640 226339 7272 42387084
Acute kidney injury 1084.87 12.43 308 226671 367029 42027327
Death 1043.16 12.43 611 226368 470574 41923782
Frequent bowel movements 1037.85 12.43 882 226097 20525 42373831
Drug specific antibody present 1017.62 12.43 474 226505 3532 42390824
Toxicity to various agents 936.17 12.43 76 226903 229060 42165296
Drug interaction 933.61 12.43 152 226827 266847 42127509
Drug level decreased 922.87 12.43 606 226373 9371 42384985
Tuberculosis 899.22 12.43 599 226380 9500 42384856
Heart rate decreased 881.04 12.43 1029 225950 35503 42358853
Arthralgia 840.42 12.43 2700 224279 202538 42191818
Faecal calprotectin increased 810.50 12.43 374 226605 2720 42391636
Febrile neutropenia 771.22 12.43 57 226922 185646 42208710
Lupus-like syndrome 745.13 12.43 355 226624 2799 42391557
Disseminated tuberculosis 744.86 12.43 343 226636 2481 42391875
Pulmonary tuberculosis 714.73 12.43 415 226564 5086 42389270
Therapeutic product effect decreased 619.94 12.43 896 226083 38254 42356102
Colectomy 617.78 12.43 284 226695 2045 42392311
Anal fistula 585.83 12.43 382 226597 5831 42388525
Anal abscess 581.94 12.43 416 226563 7434 42386922
Therapeutic response shortened 573.52 12.43 517 226462 13037 42381319
Skin cancer 556.91 12.43 473 226506 10989 42383367
Neutropenia 550.23 12.43 188 226791 199243 42195113
Anaemia 540.05 12.43 422 226557 279856 42114500
Abscess 528.48 12.43 505 226474 13743 42380613
Weight decreased 520.63 12.43 2339 224640 205609 42188747
Blood pressure increased 520.32 12.43 1451 225528 100477 42293879
Thrombocytopenia 518.64 12.43 183 226796 190096 42204260
Anal fissure 505.95 12.43 327 226652 4912 42389444
Drug abuse 496.74 12.43 13 226966 104758 42289598
Flushing 435.15 12.43 739 226240 36289 42358067
Intestinal stenosis 408.51 12.43 228 226751 2576 42391780
Malignant neoplasm progression 395.94 12.43 54 226925 108346 42286010
Platelet count decreased 384.83 12.43 129 226850 138452 42255904
Disease progression 384.75 12.43 142 226837 143514 42250842
Joint swelling 383.67 12.43 1005 225974 67017 42327339
Heart rate irregular 381.57 12.43 449 226530 15601 42378755
Hyponatraemia 379.10 12.43 47 226932 101415 42292941
Treatment failure 377.76 12.43 949 226030 61675 42332681
Apparent death 369.33 12.43 236 226743 3472 42390884
Uveitis 367.95 12.43 341 226638 8917 42385439
Clostridium difficile infection 359.16 12.43 519 226460 22140 42372216
Completed suicide 347.71 12.43 50 226929 96415 42297941
Incorrect dose administered 345.21 12.43 827 226152 52147 42342209
Abdominal pain 336.18 12.43 1943 225036 188528 42205828
Ileal stenosis 335.40 12.43 175 226804 1709 42392647
Herpes zoster 334.99 12.43 679 226300 38198 42356158
Basal cell carcinoma 331.95 12.43 501 226478 22232 42372124
Lymphoma 331.13 12.43 395 226584 13926 42380430
Overdose 327.29 12.43 79 226900 105185 42289171
Hyperkalaemia 324.45 12.43 28 226951 80430 42313926
Synovitis 318.97 12.43 404 226575 15163 42379193
Poor venous access 311.45 12.43 279 226700 6973 42387383
Confusional state 310.27 12.43 262 226717 167335 42227021
Urticaria 308.24 12.43 981 225998 73055 42321301
Blood creatinine increased 294.02 12.43 109 226870 109894 42284462
Hypotension 292.29 12.43 582 226397 257049 42137307
C-reactive protein abnormal 285.69 12.43 297 226682 8964 42385392
Drug level above therapeutic 281.30 12.43 241 226738 5665 42388691
Cardiac arrest 276.32 12.43 118 226861 109202 42285154
Rhabdomyolysis 268.55 12.43 46 226933 77973 42316383
Pyoderma gangrenosum 267.78 12.43 153 226826 1814 42392542
Drug specific antibody 267.38 12.43 96 226883 323 42394033
Intestinal obstruction 265.13 12.43 500 226479 26658 42367698
Renal impairment 264.54 12.43 128 226851 110100 42284256
Histoplasmosis disseminated 259.09 12.43 153 226826 1938 42392418
Ileostomy 252.42 12.43 122 226857 996 42393360
Pancytopenia 251.73 12.43 158 226821 117585 42276771
Malignant melanoma 248.78 12.43 278 226701 9122 42385234
White blood cell count decreased 247.46 12.43 140 226839 110256 42284100
Arthropathy 246.75 12.43 510 226469 29087 42365269
Hepatosplenic T-cell lymphoma 246.16 12.43 95 226884 411 42393945
Histoplasmosis 245.96 12.43 140 226839 1647 42392709
Contraindicated product administered 238.94 12.43 459 226520 24813 42369543
Hypersensitivity 234.99 12.43 883 226096 71487 42322869
Intentional overdose 234.44 12.43 9 226970 51447 42342909
Large intestinal stenosis 231.15 12.43 139 226840 1824 42392532
Somnolence 230.20 12.43 247 226732 140858 42253498
Incorrect drug administration rate 228.94 12.43 143 226836 2017 42392339
Neutrophil count decreased 228.17 12.43 33 226946 63382 42330974
Red blood cell sedimentation rate abnormal 227.83 12.43 178 226801 3658 42390698
Fall 223.52 12.43 582 226397 233938 42160418
Drug intolerance 220.72 12.43 931 226048 79493 42314863
Atrial fibrillation 220.40 12.43 251 226728 139342 42255014
Mucous stools 219.66 12.43 148 226831 2392 42391964
Seizure 217.51 12.43 193 226786 120368 42273988
Cytokine release syndrome 216.92 12.43 4 226975 44523 42349833
Body temperature fluctuation 215.91 12.43 125 226854 1522 42392834
Hypoglycaemia 215.69 12.43 31 226948 59823 42334533
Metabolic acidosis 211.92 12.43 17 226962 51841 42342515
Cardiac failure 211.55 12.43 156 226823 106700 42287656
Nephrolithiasis 211.46 12.43 548 226431 36282 42358074
Lymph node tuberculosis 211.15 12.43 86 226893 441 42393915
Arthritis 210.54 12.43 595 226384 41470 42352886
Diarrhoea haemorrhagic 207.52 12.43 230 226749 7477 42386879
Hallucination 206.72 12.43 30 226949 57477 42336879
Cardio-respiratory arrest 205.27 12.43 33 226946 58603 42335753
Electrocardiogram QT prolonged 203.75 12.43 13 226966 47932 42346424
Lactic acidosis 202.57 12.43 9 226970 45252 42349104
COVID-19 202.38 12.43 1180 225799 114768 42279588
International normalised ratio increased 199.06 12.43 15 226964 48153 42346203
Pneumonia legionella 195.78 12.43 132 226847 2136 42392220
Colitis ulcerative 195.10 12.43 431 226548 25744 42368612
Constipation 191.32 12.43 358 226621 161933 42232423
Hypokalaemia 190.02 12.43 72 226907 71649 42322707
Delirium 189.71 12.43 27 226952 52492 42341864
Blood glucose increased 187.06 12.43 79 226900 73620 42320736
Diverticulitis 183.49 12.43 387 226592 22386 42371970
Erythema nodosum 182.51 12.43 117 226862 1731 42392625
Weight fluctuation 182.03 12.43 190 226789 5761 42388595
Gastrointestinal inflammation 178.34 12.43 167 226812 4425 42389931
Neuropathy peripheral 177.82 12.43 168 226811 101685 42292671
Coma 176.91 12.43 35 226944 53519 42340837
Cardiac failure congestive 175.95 12.43 120 226859 85482 42308874
Inflammation 172.54 12.43 482 226497 33365 42360991
Drug reaction with eosinophilia and systemic symptoms 171.35 12.43 14 226965 42061 42352295
Systemic lupus erythematosus 169.25 12.43 228 226751 9096 42385260
Bone erosion 166.92 12.43 158 226821 4245 42390111
Defaecation urgency 166.35 12.43 146 226833 3548 42390808
Intentional product misuse 164.21 12.43 62 226917 61838 42332518
Neoplasm malignant 163.33 12.43 369 226610 22374 42371982
Body temperature decreased 161.81 12.43 282 226697 14131 42380225
Chest discomfort 158.89 12.43 716 226263 62900 42331456
Fistula discharge 158.42 12.43 89 226890 1019 42393337
Disability 157.91 12.43 176 226803 5757 42388599
Mycobacterium marinum infection 156.96 12.43 70 226909 465 42393891
Respiratory failure 156.90 12.43 276 226703 127856 42266500
Erythema 156.58 12.43 1054 225925 107739 42286617
Hypoxia 155.61 12.43 89 226890 69697 42324659
Hyperglycaemia 151.42 12.43 30 226949 45829 42348527
Bradycardia 150.38 12.43 140 226839 85344 42309012
Infusion site extravasation 143.15 12.43 161 226818 5320 42389036
Colectomy total 141.99 12.43 58 226921 300 42394056
Meningitis listeria 141.73 12.43 70 226909 602 42393754
Depressed level of consciousness 141.40 12.43 40 226939 47930 42346426
Pneumonia aspiration 139.95 12.43 46 226933 50032 42344324
Tuberculous pleurisy 139.91 12.43 61 226918 381 42393975
Myelosuppression 138.88 12.43 24 226955 40437 42353919
Aphthous ulcer 138.43 12.43 164 226815 5737 42388619
Mental status changes 138.11 12.43 28 226951 42087 42352269
Asthenia 137.66 12.43 903 226076 279890 42114466
Sedation 136.56 12.43 6 226973 30469 42363887
Gastrointestinal haemorrhage 136.22 12.43 193 226786 97533 42296823
Disorientation 135.49 12.43 17 226962 36372 42357984
Oedema peripheral 135.43 12.43 330 226649 135746 42258610
Malaise 135.14 12.43 1724 225255 210432 42183924
Rectal haemorrhage 135.04 12.43 573 226406 49033 42345323
Hodgkin's disease 133.51 12.43 72 226907 756 42393600
Injection site pain 132.78 12.43 71 226908 57727 42336629
Inflammatory bowel disease 130.67 12.43 125 226854 3404 42390952
Peritoneal tuberculosis 130.36 12.43 55 226924 313 42394043
Acute myocardial infarction 129.93 12.43 74 226905 58091 42336265
Squamous cell carcinoma 129.15 12.43 241 226738 12741 42381615
IgA nephropathy 127.82 12.43 104 226875 2270 42392086
Rectal abscess 127.35 12.43 91 226888 1624 42392732
Surgery 126.69 12.43 286 226693 17330 42377026
Mucosal inflammation 125.15 12.43 53 226926 49321 42345035
Vein rupture 124.88 12.43 73 226906 906 42393450
Full blood count abnormal 124.30 12.43 9 226970 29867 42364489
Antinuclear antibody positive 122.79 12.43 87 226892 1531 42392825
Encephalopathy 122.69 12.43 34 226945 41299 42353057
Rheumatoid factor negative 122.51 12.43 73 226906 941 42393415
Sarcoidosis 122.49 12.43 123 226856 3559 42390797
Exposure to SARS-CoV-2 122.30 12.43 61 226918 537 42393819
Loss of personal independence in daily activities 121.62 12.43 557 226422 49259 42345097
Musculoskeletal stiffness 120.96 12.43 618 226361 57147 42337209
Ileectomy 119.83 12.43 42 226937 129 42394227
Ascites 118.40 12.43 78 226901 56600 42337756
Psoriasis 118.33 12.43 543 226436 48061 42346295
Decreased appetite 117.88 12.43 578 226401 192559 42201797
Ileocaecal resection 117.73 12.43 53 226926 361 42393995
Lymphoproliferative disorder 116.54 12.43 114 226865 3193 42391163
Cardiogenic shock 116.23 12.43 24 226955 35616 42358740
Plasma cell myeloma 115.99 12.43 54 226925 47524 42346832
Blood pressure diastolic decreased 115.17 12.43 202 226777 10173 42384183
Red blood cell sedimentation rate increased 115.10 12.43 197 226782 9727 42384629
Spinal instability 115.04 12.43 59 226920 554 42393802
Agitation 114.67 12.43 104 226875 64210 42330146
Orthostatic hypotension 114.50 12.43 14 226965 30556 42363800
Acne 113.56 12.43 235 226744 13409 42380947
Blood urea increased 113.55 12.43 19 226960 32774 42361582
Suicide attempt 112.88 12.43 52 226927 46048 42348308
Aggression 112.59 12.43 47 226932 44116 42350240
Multiple organ dysfunction syndrome 112.54 12.43 216 226763 96819 42297537
Chondropathy 112.53 12.43 74 226905 1146 42393210
Dehydration 112.36 12.43 383 226596 141384 42252972
Hypomagnesaemia 111.89 12.43 11 226968 28477 42365879
Therapeutic product effect incomplete 111.60 12.43 703 226276 70236 42324120
Atlantoaxial instability 111.42 12.43 52 226927 389 42393967
Serotonin syndrome 109.82 12.43 7 226972 25838 42368518
C-reactive protein increased 109.57 12.43 645 226334 62915 42331441
Loss of therapeutic response 108.72 12.43 74 226905 1217 42393139
Ventricular fibrillation 107.58 12.43 16 226963 30107 42364249
Henoch-Schonlein purpura 107.03 12.43 90 226889 2060 42392296
Intestinal operation 106.99 12.43 42 226937 192 42394164
Bone cyst 105.46 12.43 80 226899 1571 42392785
Knee arthroplasty 104.07 12.43 176 226803 8605 42385751
Drug hypersensitivity 103.66 12.43 893 226086 98496 42295860
Altered state of consciousness 103.44 12.43 16 226963 29243 42365113
Non-Hodgkin's lymphoma 103.38 12.43 75 226904 1372 42392984
Memory impairment 102.38 12.43 71 226908 50151 42344205
Rash maculo-papular 102.10 12.43 36 226943 37467 42356889
No adverse event 101.96 12.43 40 226939 38981 42355375
Wrong technique in product usage process 101.46 12.43 50 226929 42585 42351771
Cutaneous leishmaniasis 101.17 12.43 42 226937 228 42394128
Hypocalcaemia 101.17 12.43 19 226960 30154 42364202
Therapeutic response decreased 101.09 12.43 428 226551 36584 42357772
Leukopenia 100.83 12.43 151 226828 74595 42319761
Toxic epidermal necrolysis 100.80 12.43 12 226967 26738 42367618
Dry mouth 100.76 12.43 43 226936 39836 42354520
Chronic kidney disease 100.05 12.43 64 226915 47177 42347179
Neoplasm progression 99.97 12.43 17 226962 28983 42365373
Aspartate aminotransferase increased 99.21 12.43 161 226818 77002 42317354
Hypervolaemia 99.05 12.43 6 226973 23119 42371237
Blood creatine phosphokinase increased 97.66 12.43 69 226910 48269 42346087
Coronary artery disease 96.81 12.43 86 226893 53634 42340722
Dizziness 96.80 12.43 855 226124 248399 42145957
Feeling hot 96.56 12.43 310 226669 23172 42371184
Oropharyngeal pain 96.22 12.43 465 226514 42045 42352311
Rheumatoid arthritis 95.89 12.43 464 226515 41976 42352380
Suicidal ideation 95.66 12.43 70 226909 48091 42346265
Small intestinal resection 95.62 12.43 54 226925 625 42393731
Haematuria 95.47 12.43 100 226879 57699 42336657
Pulmonary oedema 95.14 12.43 86 226893 53186 42341170
Proctocolectomy 94.45 12.43 37 226942 168 42394188
Obstructive airways disorder 93.56 12.43 11 226968 24748 42369608
Pouchitis 93.51 12.43 60 226919 889 42393467
Dysphagia 93.23 12.43 152 226827 72567 42321789
Full blood count decreased 92.28 12.43 4 226975 20556 42373800
Haemoptysis 91.83 12.43 67 226912 46100 42348256
Pleural effusion 91.71 12.43 242 226737 96924 42297432
Tumour lysis syndrome 91.62 12.43 7 226972 22224 42372132
Agranulocytosis 91.19 12.43 25 226954 30587 42363769
Pain 90.07 12.43 1816 225163 243032 42151324
Drug tolerance decreased 90.06 12.43 85 226894 2275 42392081
Impaired work ability 89.97 12.43 199 226780 11892 42382464
Drug eruption 89.82 12.43 299 226680 22776 42371580
Blood bilirubin increased 89.81 12.43 57 226922 42195 42352161
Urinary retention 89.66 12.43 57 226922 42157 42352199
Listeriosis 89.31 12.43 68 226911 1343 42393013
Chronic obstructive pulmonary disease 88.56 12.43 124 226855 62990 42331366
Lung neoplasm malignant 86.33 12.43 261 226718 18886 42375470
Troponin increased 84.60 12.43 4 226975 19058 42375298
Cytomegalovirus colitis 84.21 12.43 105 226874 3876 42390480
Alanine aminotransferase abnormal 83.85 12.43 117 226862 4827 42389529
Neurotoxicity 83.46 12.43 13 226966 23638 42370718
Cholangitis sclerosing 83.30 12.43 74 226905 1828 42392528
Enthesopathy 83.00 12.43 115 226864 4713 42389643
Septic shock 83.00 12.43 233 226746 91439 42302917
B-cell lymphoma 82.93 12.43 116 226863 4797 42389559
Upper gastrointestinal haemorrhage 82.62 12.43 29 226950 30270 42364086
Ventricular tachycardia 82.02 12.43 29 226950 30131 42364225
Hypothyroidism 82.01 12.43 34 226945 32050 42362306
Diabetic ketoacidosis 81.94 12.43 11 226968 22356 42372000
Pulmonary thrombosis 81.82 12.43 154 226825 8194 42386162
Alanine aminotransferase increased 81.30 12.43 223 226756 88183 42306173
Subdural haematoma 81.01 12.43 13 226966 23125 42371231
Gamma-glutamyltransferase increased 80.58 12.43 36 226943 32461 42361895
Haemoglobin decreased 80.43 12.43 397 226582 132074 42262282
Legionella infection 80.24 12.43 46 226933 549 42393807
Cognitive disorder 79.92 12.43 41 226938 34131 42360225
Colon cancer 79.69 12.43 166 226813 9515 42384841
Sleep disorder due to a general medical condition 79.66 12.43 3 226976 17450 42376906
Respiratory arrest 79.60 12.43 26 226953 28398 42365958
Small intestinal stenosis 79.33 12.43 53 226926 844 42393512
Dysarthria 78.87 12.43 58 226921 39749 42354607
Hepatic failure 78.80 12.43 53 226926 38047 42356309
Stevens-Johnson syndrome 78.69 12.43 12 226967 22166 42372190
Dislocation of vertebra 78.60 12.43 41 226938 400 42393956
Enterostomy 78.50 12.43 27 226952 77 42394279
Mineral metabolism disorder 78.41 12.43 40 226939 371 42393985
Throat tightness 78.32 12.43 164 226815 9435 42384921
Hallucination, visual 77.81 12.43 10 226969 21010 42373346
Blood alkaline phosphatase increased 77.55 12.43 41 226938 33556 42360800
Unresponsive to stimuli 77.53 12.43 35 226944 31368 42362988
Hypophosphataemia 77.45 12.43 10 226969 20935 42373421
Cerebral haemorrhage 76.91 12.43 57 226922 38909 42355447
Hypophagia 76.66 12.43 24 226955 26932 42367424
Pneumonia 76.55 12.43 1690 225289 420459 41973897
Impaired quality of life 75.31 12.43 205 226774 13972 42380384
Intestinal fistula 74.89 12.43 57 226922 1125 42393231
Hyperlipidaemia 73.31 12.43 13 226966 21503 42372853
Irritability 73.21 12.43 29 226950 28099 42366257
Pericarditis 73.02 12.43 196 226783 13248 42381108
Stoma creation 72.29 12.43 26 226953 88 42394268
Haemorrhage intracranial 72.04 12.43 5 226974 17187 42377169
Activated partial thromboplastin time prolonged 71.69 12.43 3 226976 15900 42378456
Balance disorder 71.55 12.43 89 226890 47556 42346800
Dyskinesia 71.50 12.43 23 226956 25367 42368989
Drug withdrawal syndrome 71.33 12.43 14 226965 21535 42372821
Faeces soft 71.31 12.43 108 226871 4804 42389552
Pallor 71.24 12.43 324 226655 28562 42365794
Joint ankylosis 70.98 12.43 64 226915 1613 42392743
Tooth fracture 70.94 12.43 99 226880 4085 42390271
Pregnancy of partner 70.62 12.43 38 226941 397 42393959
Eosinophilia 70.44 12.43 44 226935 32855 42361501
Infected fistula 70.26 12.43 31 226948 200 42394156
Mass 69.79 12.43 148 226831 8591 42385765
Wheezing 69.75 12.43 115 226864 54666 42339690
Fluid retention 69.50 12.43 41 226938 31578 42362778
Hyperbilirubinaemia 69.16 12.43 13 226966 20622 42373734
Jaundice 69.04 12.43 50 226929 34539 42359817
End stage renal disease 68.85 12.43 5 226974 16553 42377803
Abscess intestinal 68.83 12.43 65 226914 1741 42392615
Therapy interrupted 68.51 12.43 17 226962 22233 42372123
Salmonellosis 68.07 12.43 56 226923 1242 42393114
Proctectomy 67.99 12.43 27 226952 128 42394228
Serum sickness 67.98 12.43 71 226908 2154 42392202
Tenosynovitis 67.84 12.43 103 226876 4592 42389764
Blood pressure systolic increased 67.71 12.43 312 226667 27656 42366700
Latent tuberculosis 67.45 12.43 62 226917 1603 42392753
Contraindication to vaccination 67.20 12.43 18 226961 12 42394344
Pharyngitis streptococcal 67.20 12.43 93 226886 3807 42390549
Abdominal abscess 66.99 12.43 107 226872 4986 42389370
Demyelination 66.66 12.43 88 226891 3441 42390915
Heart rate increased 66.65 12.43 499 226480 52756 42341600
Perirectal abscess 65.97 12.43 64 226915 1774 42392582
Myoclonus 65.95 12.43 7 226972 17058 42377298
Cytopenia 65.56 12.43 8 226971 17489 42376867
Angioedema 65.21 12.43 78 226901 42399 42351957
Dyspnoea exertional 65.04 12.43 104 226875 50044 42344312
Sepsis 64.25 12.43 715 226264 198619 42195737
Blood cholesterol increased 64.17 12.43 31 226948 26710 42367646
Ankylosing spondylitis 64.04 12.43 126 226853 6930 42387426
Myasthenia gravis 63.98 12.43 6 226973 16131 42378225
Lethargy 63.93 12.43 94 226885 46796 42347560
Disturbance in attention 63.87 12.43 40 226939 29826 42364530
Blood uric acid increased 63.77 12.43 5 226974 15542 42378814
Small intestinal obstruction 63.69 12.43 218 226761 16843 42377513
Pulmonary hypertension 63.51 12.43 23 226956 23546 42370810
Drug effective for unapproved indication 63.32 12.43 121 226858 6512 42387844
Acute respiratory failure 63.30 12.43 68 226911 38790 42355566
Proctitis 63.07 12.43 78 226901 2855 42391501
Melaena 62.90 12.43 68 226911 38678 42355678
Gait disturbance 62.80 12.43 288 226691 97712 42296644
Poisoning 62.40 12.43 4 226975 14695 42379661
Urinary tract infection 62.31 12.43 294 226685 98990 42295366
Extrapulmonary tuberculosis 61.76 12.43 26 226953 147 42394209
Colitis 61.49 12.43 442 226537 46130 42348226
Blood potassium increased 61.44 12.43 12 226967 18524 42375832
Blood pressure diastolic increased 61.34 12.43 117 226862 6288 42388068
Sinus tachycardia 61.27 12.43 17 226962 20636 42373720
Aspiration 60.52 12.43 11 226968 17875 42376481
Product quality issue 60.50 12.43 11 226968 17871 42376485
Sinus bradycardia 60.31 12.43 5 226974 14848 42379508
Wisdom teeth removal 60.28 12.43 29 226950 234 42394122
Testicular seminoma (pure) 60.21 12.43 27 226952 182 42394174
Terminal state 59.66 12.43 94 226885 4329 42390027
Pneumocystis jirovecii pneumonia 59.55 12.43 279 226700 24902 42369454
Haematocrit decreased 59.22 12.43 59 226920 34849 42359507
Miosis 59.10 12.43 3 226976 13443 42380913
Joint lock 58.90 12.43 53 226926 1332 42393024
Terminal ileitis 58.71 12.43 38 226941 572 42393784
Steroid dependence 58.56 12.43 118 226861 6604 42387752
Abnormal behaviour 58.56 12.43 34 226945 26417 42367939
Anal stenosis 58.44 12.43 31 226948 314 42394042
Clear cell renal cell carcinoma 58.42 12.43 51 226928 1230 42393126
Iritis 58.31 12.43 59 226920 1723 42392633
Diarrhoea 58.20 12.43 1942 225037 458907 41935449
Rectal cancer 58.17 12.43 67 226912 2273 42392083
Type IV hypersensitivity reaction 57.61 12.43 68 226911 2369 42391987
Polyarthritis 57.46 12.43 100 226879 5004 42389352
Insomnia 57.43 12.43 381 226598 117872 42276484
Asthma 57.41 12.43 157 226822 62157 42332199
Withdrawal syndrome 57.25 12.43 6 226973 14769 42379587
Respiratory depression 56.97 12.43 15 226964 18853 42375503
Hyperphosphataemia 56.85 12.43 3 226976 13001 42381355
Pustular psoriasis 56.39 12.43 63 226916 2066 42392290
Skin laceration 56.35 12.43 184 226795 13874 42380482
Labelled drug-drug interaction medication error 56.28 12.43 8 226971 15574 42378782
Drug level abnormal 56.03 12.43 29 226950 278 42394078
Tooth loss 55.64 12.43 88 226891 4066 42390290
Glomerular filtration rate decreased 55.45 12.43 10 226969 16341 42378015
Ear infection bacterial 55.32 12.43 17 226962 29 42394327
Vomiting 55.26 12.43 1150 225829 288573 42105783
Psoriatic arthropathy 54.97 12.43 271 226708 24696 42369660
Multiple sclerosis relapse 54.74 12.43 6 226973 14258 42380098
Hip arthroplasty 54.67 12.43 100 226879 5205 42389151
Blood lactate dehydrogenase increased 54.31 12.43 36 226943 26045 42368311
Ophthalmic herpes zoster 54.30 12.43 46 226933 1064 42393292
Faecal calprotectin abnormal 54.14 12.43 29 226950 300 42394056
Bone marrow failure 53.81 12.43 58 226921 33035 42361321
Lymphocyte count decreased 53.19 12.43 42 226937 27767 42366589
Dry skin 53.10 12.43 111 226868 48227 42346129
Fatigue 53.07 12.43 1844 225135 433797 41960559
Joint arthroplasty 53.02 12.43 43 226936 934 42393422
Ischaemic stroke 53.01 12.43 26 226953 22207 42372149
Cutaneous T-cell lymphoma 52.71 12.43 59 226920 1939 42392417
Pseudopolyp 52.66 12.43 28 226951 285 42394071
Infectious mononucleosis 52.57 12.43 38 226941 691 42393665
Anal cancer 52.37 12.43 32 226947 433 42393923
Intentional self-injury 52.20 12.43 9 226970 15193 42379163
Tuberculosis gastrointestinal 52.02 12.43 26 226953 230 42394126
Cerebrovascular accident 51.85 12.43 304 226675 96856 42297500
Vasectomy 51.74 12.43 17 226962 40 42394316
Intestinal sepsis 51.56 12.43 38 226941 713 42393643
Onychoclasis 51.44 12.43 67 226912 2585 42391771
Incorrect route of product administration 51.36 12.43 33 226946 24272 42370084
Sinusitis bacterial 51.29 12.43 34 226945 534 42393822
Colostomy 51.14 12.43 35 226944 581 42393775
Paradoxical psoriasis 51.05 12.43 22 226957 133 42394223
Device issue 51.05 12.43 6 226973 13503 42380853
Subarachnoid haemorrhage 50.96 12.43 8 226971 14464 42379892
Joint stiffness 50.95 12.43 163 226816 12159 42382197
Renal failure 50.55 12.43 505 226474 143221 42251135
Pelvic abscess 50.49 12.43 43 226936 1002 42393354
Haematemesis 50.14 12.43 52 226927 30147 42364209
Tooth infection 49.92 12.43 123 226856 7888 42386468
Speech disorder 49.65 12.43 49 226930 29072 42365284
Anti-cyclic citrullinated peptide antibody positive 49.65 12.43 56 226923 1856 42392500
Prostate cancer 49.62 12.43 407 226572 44236 42350120
Oedema 49.43 12.43 129 226850 51872 42342484
Hepatotoxicity 49.42 12.43 37 226942 25130 42369226
Anuria 49.36 12.43 3 226976 11529 42382827
Ileostomy closure 49.17 12.43 18 226961 65 42394291
Cytology abnormal 49.12 12.43 29 226950 367 42393989
Generalised tonic-clonic seizure 49.01 12.43 41 226938 26338 42368018
Short stature 48.84 12.43 30 226949 410 42393946
Rectal stenosis 48.83 12.43 24 226955 204 42394152
Psychotic disorder 48.83 12.43 50 226929 29158 42365198
Angina pectoris 48.82 12.43 62 226917 32834 42361522
T-cell lymphoma 48.79 12.43 44 226935 1109 42393247
Blood sodium decreased 48.47 12.43 18 226961 18144 42376212
Accidental exposure to product 48.39 12.43 24 226955 20369 42373987
Coagulopathy 48.34 12.43 29 226950 22133 42372223
Antinuclear antibody increased 48.21 12.43 28 226951 343 42394013
Haematoma 47.96 12.43 47 226932 27976 42366380
Delusion 47.88 12.43 10 226969 14724 42379632
Restlessness 47.85 12.43 51 226928 29198 42365158
Cholestasis 47.73 12.43 63 226916 32816 42361540
Transient ischaemic attack 47.61 12.43 66 226913 33673 42360683
Hepatocellular injury 47.55 12.43 34 226945 23644 42370712
Dystonia 47.55 12.43 6 226973 12784 42381572
Sports injury 47.53 12.43 21 226958 136 42394220
Syncope 47.39 12.43 322 226657 99084 42295272
Intestinal ulcer 47.36 12.43 42 226937 1035 42393321
Red blood cell count decreased 47.17 12.43 63 226916 32652 42361704
Coccidioidomycosis 46.91 12.43 38 226941 824 42393532
Bladder transitional cell carcinoma 46.39 12.43 64 226915 2612 42391744
Appendicectomy 46.20 12.43 48 226931 1447 42392909
Epstein Barr virus positive mucocutaneous ulcer 46.06 12.43 32 226947 545 42393811
Hepatic cytolysis 45.96 12.43 45 226934 26799 42367557
Erectile dysfunction 45.94 12.43 39 226940 24874 42369482
Glycosylated haemoglobin increased 45.84 12.43 7 226972 12917 42381439
Neutropenic sepsis 45.69 12.43 14 226965 15932 42378424
DNA antibody positive 45.44 12.43 16 226963 50 42394306
Ejection fraction decreased 45.30 12.43 31 226948 22056 42372300
Enterovesical fistula 45.22 12.43 39 226940 925 42393431
Tongue disorder 45.12 12.43 93 226886 5290 42389066
Inappropriate antidiuretic hormone secretion 44.81 12.43 16 226963 16525 42377831
Throat irritation 44.72 12.43 162 226817 12874 42381482
Gastrointestinal infection 44.66 12.43 106 226873 6637 42387719
Transplant rejection 44.61 12.43 9 226970 13579 42380777
Neutrophil count increased 44.49 12.43 25 226954 19779 42374577
Renal tubular necrosis 44.46 12.43 21 226958 18333 42376023
Hepatic encephalopathy 44.38 12.43 16 226963 16426 42377930
Proctalgia 44.30 12.43 109 226870 6984 42387372
White coat hypertension 44.11 12.43 26 226953 328 42394028
Bladder neoplasm 44.10 12.43 47 226932 1460 42392896
Adenocarcinoma 43.71 12.43 55 226924 2049 42392307
Circulatory collapse 43.59 12.43 37 226942 23599 42370757
Colostomy closure 43.55 12.43 15 226964 43 42394313
Skin exfoliation 43.50 12.43 98 226881 41455 42352901
Urine output decreased 43.22 12.43 4 226975 10869 42383487
Rectal tenesmus 43.14 12.43 41 226938 1107 42393249
Device leakage 43.07 12.43 3 226976 10282 42384074
Leukocytosis 43.04 12.43 57 226922 29651 42364705
Arthritis bacterial 43.00 12.43 96 226883 5772 42388584
Nephropathy toxic 42.78 12.43 18 226961 16820 42377536
Renal injury 42.76 12.43 7 226972 12273 42382083
Paranoia 42.63 12.43 11 226968 14015 42380341
Loss of consciousness 42.62 12.43 302 226677 92052 42302304
Nasopharyngitis 42.59 12.43 656 226323 83340 42311016
Cell marker increased 42.56 12.43 28 226951 434 42393922
Febrile bone marrow aplasia 42.54 12.43 3 226976 10178 42384178
Stress 42.32 12.43 390 226589 43822 42350534
Influenza 41.91 12.43 511 226468 61664 42332692
Anaphylactic reaction 41.90 12.43 379 226600 42364 42351992
Injection site erythema 41.88 12.43 28 226951 20167 42374189
Tongue neoplasm malignant stage unspecified 41.81 12.43 35 226944 796 42393560
Hypernatraemia 41.79 12.43 3 226976 10029 42384327
Pericarditis tuberculous 41.50 12.43 16 226963 69 42394287
Depressed mood 41.44 12.43 38 226941 23346 42371010
Osteonecrosis of jaw 41.44 12.43 25 226954 19024 42375332
Product administration error 41.43 12.43 23 226956 18320 42376036
Intervertebral disc space narrowing 41.34 12.43 40 226939 1105 42393251
Renal cell carcinoma 41.27 12.43 91 226888 5426 42388930
Gastrointestinal stoma complication 41.21 12.43 46 226933 1507 42392849
Drug ineffective for unapproved indication 41.10 12.43 401 226578 45762 42348594
Aplastic anaemia 41.08 12.43 8 226971 12376 42381980
Venous injury 41.06 12.43 25 226954 336 42394020
Muscular weakness 41.04 12.43 268 226711 83230 42311126
Lymphopenia 40.70 12.43 33 226946 21530 42372826
Myocardial infarction 40.63 12.43 443 226536 123566 42270790
Chills 40.43 12.43 715 226264 93351 42301005
Streptococcal infection 40.18 12.43 96 226883 6036 42388320
Treatment noncompliance 40.13 12.43 88 226891 37584 42356772
Eosinophil count increased 40.13 12.43 5 226974 10758 42383598
Oxygen saturation abnormal 40.12 12.43 51 226928 1920 42392436
Atelectasis 39.94 12.43 27 226952 19334 42375022
Atrial flutter 39.89 12.43 21 226958 17230 42377126
Anorectal disorder 39.84 12.43 41 226938 1222 42393134
Pulmonary arterial hypertension 39.83 12.43 4 226975 10183 42384173
Cyst 39.79 12.43 88 226891 5258 42389098
Depression 39.68 12.43 390 226589 110973 42283383
Cytomegalovirus infection 39.45 12.43 301 226678 32005 42362351
Alopecia areata 39.19 12.43 24 226955 326 42394030
Brain oedema 39.06 12.43 19 226960 16308 42378048
Thrombotic microangiopathy 38.86 12.43 15 226964 14767 42379589
Pathogen resistance 38.83 12.43 7 226972 11443 42382913
Mental impairment 38.73 12.43 9 226970 12308 42382048
Sleep disorder 38.69 12.43 129 226850 47966 42346390
Hyperthyroidism 38.63 12.43 14 226965 14327 42380029
Tuberculin test positive 38.54 12.43 39 226940 1139 42393217
Neuralgia 38.41 12.43 48 226931 25599 42368757
Varicella 38.24 12.43 51 226928 2014 42392342
Cerebral infarction 38.23 12.43 67 226912 31102 42363254
Renal colic 38.19 12.43 51 226928 2017 42392339
Hand fracture 38.15 12.43 61 226918 2845 42391511
Respiratory distress 38.04 12.43 106 226873 41714 42352642
Therapy non-responder 37.92 12.43 443 226536 52916 42341440
Illness 37.90 12.43 245 226734 24685 42369671
Immunosuppression 37.89 12.43 115 226864 8338 42386018
Subcutaneous abscess 37.69 12.43 78 226901 4450 42389906
Headache 37.68 12.43 1596 225383 237773 42156583
Erythrodermic psoriasis 37.45 12.43 37 226942 1049 42393307
Suspected COVID-19 37.33 12.43 42 226937 1388 42392968
Aphasia 37.20 12.43 44 226935 24039 42370317
Ankle deformity 37.17 12.43 20 226959 209 42394147
Parkinsonism 37.12 12.43 6 226973 10617 42383739
Postoperative abscess 37.05 12.43 25 226954 405 42393951
Transurethral prostatectomy 37.05 12.43 25 226954 405 42393951
Cardiomegaly 36.48 12.43 22 226957 16744 42377612
Salivary hypersecretion 36.45 12.43 7 226972 10936 42383420
Epstein-Barr virus associated lymphoma 36.18 12.43 36 226943 1030 42393326
Hiccups 36.13 12.43 10 226969 12161 42382195
Thyroid cancer 36.08 12.43 46 226933 1737 42392619
Double stranded DNA antibody 36.08 12.43 11 226968 18 42394338
Campylobacter infection 35.99 12.43 41 226938 1374 42392982
Osteosclerosis 35.61 12.43 42 226937 1462 42392894
Pneumonitis 35.58 12.43 109 226870 41609 42352747
Burns second degree 35.27 12.43 91 226888 6005 42388351
Needle issue 35.26 12.43 3 226976 8724 42385632
Post procedural infection 35.18 12.43 88 226891 5697 42388659
Respiratory symptom 35.15 12.43 8 226971 11098 42383258
Mobility decreased 35.09 12.43 314 226665 34992 42359364
Tooth extraction 35.06 12.43 85 226894 5395 42388961
Mycobacterial infection 35.02 12.43 56 226923 2612 42391744
Hypovolaemia 34.92 12.43 9 226970 11476 42382880
Growth retardation 34.64 12.43 53 226926 2379 42391977
Colon dysplasia 34.63 12.43 19 226960 207 42394149
Mania 34.60 12.43 7 226972 10540 42383816
Enterocutaneous fistula 34.58 12.43 38 226941 1223 42393133
Plasmablastic lymphoma 34.57 12.43 28 226951 607 42393749
Gastric haemorrhage 34.45 12.43 7 226972 10508 42383848
Shock haemorrhagic 34.39 12.43 22 226957 16220 42378136
Pyrexia 34.34 12.43 1732 225247 392310 42002046
White blood cell count increased 34.20 12.43 124 226855 44963 42349393
Contusion 34.19 12.43 112 226867 41873 42352483
Dyspnoea 34.03 12.43 1970 225009 440651 41953705
Breath sounds abnormal 33.97 12.43 11 226968 12082 42382274
Hidradenitis 33.79 12.43 44 226935 1697 42392659
Acute pulmonary histoplasmosis 33.79 12.43 18 226961 184 42394172
Diabetes mellitus inadequate control 33.76 12.43 20 226959 15370 42378986
Listeria sepsis 33.71 12.43 19 226960 219 42394137
Peritonsillar abscess 33.52 12.43 25 226954 478 42393878
Opportunistic infection 33.41 12.43 47 226932 1954 42392402
Product dose omission issue 33.24 12.43 600 226379 153765 42240591
Product prescribing error 33.06 12.43 55 226924 26057 42368299
Acidosis 33.05 12.43 12 226967 12267 42382089
Intestinal perforation 33.05 12.43 130 226849 10744 42383612
Cardiac disorder 33.02 12.43 141 226838 48791 42345565
Seminoma 32.97 12.43 21 226958 307 42394049
Mitral valve incompetence 32.69 12.43 24 226955 16465 42377891
Hernia 32.54 12.43 131 226848 10942 42383414
Psychomotor hyperactivity 32.54 12.43 9 226970 10949 42383407
Cardiac failure acute 32.41 12.43 16 226963 13617 42380739
Intestinal anastomosis 32.40 12.43 24 226955 454 42393902
Nocturia 32.33 12.43 12 226967 12100 42382256
Ostomy bag placement 32.21 12.43 10 226969 18 42394338
Body temperature increased 32.14 12.43 202 226777 20156 42374200
Seronegative arthritis 32.04 12.43 36 226943 1188 42393168
Cutaneous lymphoma 31.94 12.43 15 226964 114 42394242
Prothrombin time prolonged 31.66 12.43 6 226973 9463 42384893
Epilepsy 31.42 12.43 57 226922 26114 42368242
Blood calcium decreased 31.39 12.43 10 226969 11098 42383258
Toxic skin eruption 31.33 12.43 17 226962 13713 42380643
Obesity 31.30 12.43 25 226954 16434 42377922
Dermatitis psoriasiform 31.29 12.43 47 226932 2075 42392281
Fistula repair 31.20 12.43 10 226969 21 42394335
Substance abuse 31.18 12.43 5 226974 8900 42385456
Diffuse large B-cell lymphoma 31.18 12.43 116 226863 9338 42385018
Acute hepatic failure 31.15 12.43 27 226952 17046 42377310
Drug specific antibody absent 31.10 12.43 13 226966 72 42394284
Shock 31.04 12.43 68 226911 29053 42365303
Gynaecomastia 31.03 12.43 14 226965 12553 42381803
Periumbilical abscess 30.95 12.43 13 226966 73 42394283
Acute myeloid leukaemia 30.94 12.43 44 226935 22212 42372144
Hepatic steatosis 30.92 12.43 208 226771 21240 42373116
Anxiety 30.78 12.43 445 226534 118115 42276241
COVID-19 pneumonia 30.77 12.43 42 226937 21571 42372785
Superficial spreading melanoma stage unspecified 30.68 12.43 18 226961 225 42394131
Tonsillitis 30.53 12.43 54 226925 2737 42391619
Muscle rigidity 30.46 12.43 13 226966 12046 42382310
Crohn's disease 30.43 12.43 56 226923 2928 42391428
Ear infection 30.37 12.43 142 226837 12662 42381694
Testis cancer 30.30 12.43 39 226940 1487 42392869
Nasal congestion 30.15 12.43 264 226715 29237 42365119
Arteriosclerosis coronary artery 30.07 12.43 33 226946 18644 42375712
Ataxia 30.03 12.43 25 226954 16100 42378256
Adrenal insufficiency 29.85 12.43 34 226945 18890 42375466
Arteriosclerosis 29.83 12.43 31 226948 17958 42376398
Left ventricular dysfunction 29.69 12.43 12 226967 11489 42382867
Tricuspid valve incompetence 29.68 12.43 11 226968 11102 42383254
Chromaturia 29.52 12.43 25 226954 15964 42378392
Epstein-Barr virus infection 29.39 12.43 116 226863 9602 42384754
Catarrh 29.27 12.43 84 226895 5902 42388454
Rhinitis 29.27 12.43 134 226845 11843 42382513
Skin infection 29.20 12.43 113 226866 9267 42385089
Arrhythmia 29.20 12.43 113 226866 40204 42354152
Haematotoxicity 29.12 12.43 11 226968 10974 42383382
Unevaluable event 28.95 12.43 90 226889 34198 42360158
Neoplasm prostate 28.87 12.43 18 226961 253 42394103
Pollakiuria 28.87 12.43 47 226932 22458 42371898
Wrist fracture 28.45 12.43 48 226931 2342 42392014
Generalised oedema 28.29 12.43 24 226955 15312 42379044
Lung neoplasm 28.18 12.43 71 226908 4617 42389739
Neurogenic shock 28.04 12.43 19 226960 310 42394046
Blood triglycerides increased 27.97 12.43 26 226953 15870 42378486
Anal fissure haemorrhage 27.92 12.43 12 226967 72 42394284
Pyoderma 27.77 12.43 15 226964 158 42394198
Electrolyte imbalance 27.77 12.43 30 226949 17071 42377285
Drainage 27.73 12.43 11 226968 52 42394304
Haemodialysis 27.66 12.43 10 226969 10250 42384106
Episcleritis 27.62 12.43 16 226963 195 42394161
Axial spondyloarthritis 27.51 12.43 23 226956 522 42393834
Hyperuricaemia 27.50 12.43 8 226971 9416 42384940
Hepatitis cholestatic 27.48 12.43 9 226970 9815 42384541
Anastomotic ulcer 27.47 12.43 22 226957 469 42393887
Exposure during pregnancy 27.37 12.43 6 226973 8542 42385814
Gastroenteritis salmonella 27.33 12.43 26 226953 703 42393653
Granuloma 27.28 12.43 64 226915 3977 42390379
Feeling cold 27.27 12.43 139 226840 12834 42381522
Colonoscopy abnormal 27.25 12.43 12 226967 77 42394279
Immune recovery uveitis 27.25 12.43 12 226967 77 42394279
Schizophrenia 27.25 12.43 11 226968 10539 42383817
Ventricular extrasystoles 27.19 12.43 19 226960 13371 42380985
Chlamydial infection 27.14 12.43 18 226961 283 42394073
Small intestine carcinoma 27.05 12.43 25 226954 651 42393705
Ageusia 27.02 12.43 14 226965 11591 42382765
Physical disability 26.93 12.43 41 226938 1832 42392524
Polyneuropathy 26.83 12.43 36 226943 18625 42375731
Osteolysis 26.72 12.43 59 226920 3521 42390835
Dysuria 26.69 12.43 81 226898 31015 42363341
Antibody test positive 26.58 12.43 26 226953 728 42393628
Polyuria 26.58 12.43 10 226969 10001 42384355
Fistula inflammation 26.54 12.43 7 226972 4 42394352
Bowel movement irregularity 26.53 12.43 58 226921 3438 42390918
Obstruction 26.47 12.43 54 226925 3049 42391307
Injury 26.44 12.43 49 226930 22267 42372089
Rheumatoid factor positive 26.39 12.43 27 226952 799 42393557
Drain placement 26.38 12.43 12 226967 84 42394272
Angina unstable 26.37 12.43 14 226965 11434 42382922
Pulmonary alveolar haemorrhage 26.35 12.43 24 226955 14792 42379564
Faecal calprotectin decreased 26.34 12.43 9 226970 25 42394331
Hyperammonaemia 26.27 12.43 5 226974 7861 42386495
Injection site papule 26.26 12.43 19 226960 346 42394010
Urinary incontinence 26.19 12.43 47 226932 21621 42372735
Tachypnoea 26.17 12.43 47 226932 21615 42372741
Device dislocation 26.10 12.43 5 226974 7826 42386530
Sudden death 26.09 12.43 30 226949 16599 42377757
Eye laser surgery 26.08 12.43 9 226970 26 42394330
Circumcision 25.96 12.43 10 226969 43 42394313
Gastrointestinal carcinoma 25.75 12.43 41 226938 1905 42392451
Cytomegalovirus enteritis 25.59 12.43 24 226955 637 42393719
Electrocardiogram abnormal 25.52 12.43 11 226968 10134 42384222
Postoperative wound infection 25.51 12.43 77 226902 5565 42388791
Hepatitis acute 25.50 12.43 8 226971 8967 42385389
Burn infection 25.44 12.43 6 226973 0 42394356
Hodgkin's disease nodular sclerosis 25.38 12.43 7 226972 6 42394350
Decubitus ulcer 25.36 12.43 12 226967 10465 42383891
Sacroiliitis 25.19 12.43 41 226938 1941 42392415
Oral surgery 25.14 12.43 23 226956 591 42393765
Thinking abnormal 25.12 12.43 4 226975 7157 42387199
Serum sickness-like reaction 25.11 12.43 16 226963 234 42394122
Hypothermia 25.09 12.43 18 226961 12497 42381859
Vein collapse 25.00 12.43 15 226964 196 42394160
Malignant melanoma stage I 24.93 12.43 12 226967 97 42394259
Polychondritis 24.92 12.43 19 226960 376 42393980
Hypertransaminasaemia 24.87 12.43 9 226970 9218 42385138
Blood potassium decreased 24.83 12.43 44 226935 20340 42374016
Apathy 24.78 12.43 7 226972 8399 42385957
Pneumocystis jirovecii infection 24.67 12.43 50 226929 2810 42391546
Status epilepticus 24.56 12.43 28 226951 15550 42378806
Product dose omission in error 24.55 12.43 7 226972 8347 42386009
Prescribed underdose 24.55 12.43 12 226967 10270 42384086
Pseudopolyposis 24.43 12.43 11 226968 75 42394281
Pharyngitis 24.41 12.43 103 226876 8787 42385569
Post transplant lymphoproliferative disorder 24.40 12.43 9 226970 9111 42385245
Breast feeding 24.39 12.43 7 226972 8 42394348
Taste disorder 24.23 12.43 12 226967 10195 42384161
Proteinuria 24.22 12.43 54 226925 22929 42371427
Therapy cessation 24.14 12.43 45 226934 20405 42373951
Eosinophilic oesophagitis 24.08 12.43 24 226955 688 42393668
Normochromic normocytic anaemia 24.01 12.43 9 226970 9022 42385334
Gastrointestinal fistula 23.99 12.43 22 226957 567 42393789
Injection site pruritus 23.98 12.43 10 226969 9395 42384961
Tooth abscess 23.97 12.43 85 226894 6683 42387673
Gastrointestinal mucosa hyperaemia 23.96 12.43 18 226961 348 42394008
Anorectal discomfort 23.86 12.43 43 226936 2212 42392144
Pain in extremity 23.84 12.43 1005 225974 149599 42244757
Hypopnoea 23.77 12.43 94 226885 7788 42386568
Migraine 23.72 12.43 223 226756 25191 42369165
Renal neoplasm 23.67 12.43 34 226945 1441 42392915
Vision blurred 23.61 12.43 178 226801 53521 42340835
Dental implantation 23.49 12.43 11 226968 83 42394273
Muscle spasms 23.37 12.43 612 226367 85432 42308924
Blister 23.31 12.43 72 226907 27418 42366938
Listeria encephalitis 23.27 12.43 10 226969 60 42394296
Brain natriuretic peptide increased 23.26 12.43 4 226975 6766 42387590
Blood calcium increased 23.20 12.43 8 226971 8446 42385910
Visual acuity reduced 23.12 12.43 36 226943 17514 42376842
Hypoacusis 23.12 12.43 40 226939 18662 42375694
Pneumonia cryptococcal 23.10 12.43 34 226945 1474 42392882
Right ventricular failure 23.04 12.43 11 226968 9544 42384812
Genital cancer male 23.03 12.43 6 226973 3 42394353
Skin mass 22.99 12.43 67 226912 4749 42389607
Visual impairment 22.93 12.43 135 226844 42978 42351378
Neuritis 22.92 12.43 3 226976 6217 42388139
Graft versus host disease 22.91 12.43 21 226958 12904 42381452
Antiphospholipid syndrome 22.82 12.43 22 226957 605 42393751
Aortic stenosis 22.78 12.43 9 226970 8736 42385620
Granulocytopenia 22.76 12.43 5 226974 7109 42387247
Elbow operation 22.76 12.43 13 226966 154 42394202
Hypogammaglobulinaemia 22.69 12.43 18 226961 11873 42382483
Colon injury 22.67 12.43 12 226967 121 42394235
Productive cough 22.64 12.43 171 226808 51396 42342960
Bronchiectasis 22.62 12.43 169 226810 17850 42376506
Sleep apnoea syndrome 22.58 12.43 51 226928 21557 42372799
Pericardial effusion 22.54 12.43 80 226899 29195 42365161
Ocular hyperaemia 22.52 12.43 154 226825 15809 42378547
Behaviour disorder 22.49 12.43 5 226974 7049 42387307
Gastric ulcer haemorrhage 22.47 12.43 3 226976 6124 42388232
Concomitant disease aggravated 22.39 12.43 4 226975 6582 42387774
Haemolytic anaemia 22.34 12.43 19 226960 12108 42382248
Oligoarthritis 22.32 12.43 14 226965 199 42394157
Tooth disorder 22.22 12.43 124 226855 11855 42382501
Gastrointestinal stenosis 22.19 12.43 13 226966 162 42394194
Infective pulmonary exacerbation of cystic fibrosis 22.16 12.43 7 226972 7811 42386545
SARS-CoV-2 test positive 22.14 12.43 95 226884 8165 42386191
Eye infection 22.11 12.43 62 226917 4299 42390057
Left ventricular hypertrophy 22.06 12.43 11 226968 9308 42385048
Toxic encephalopathy 22.02 12.43 5 226974 6948 42387408
Therapy partial responder 21.96 12.43 46 226933 19975 42374381
Atrioventricular block first degree 21.94 12.43 4 226975 6487 42387869
Injection site reaction 21.93 12.43 31 226948 15690 42378666
Drug-induced liver injury 21.90 12.43 117 226862 38156 42356200
Device malfunction 21.88 12.43 20 226959 12307 42382049
Atrioventricular block 21.80 12.43 12 226967 9603 42384753
Gastric ulcer 21.72 12.43 40 226939 18222 42376134
Pulseless electrical activity 21.46 12.43 9 226970 8428 42385928
SAPHO syndrome 21.44 12.43 18 226961 411 42393945
Palpitations 21.42 12.43 385 226594 50412 42343944
Skin injury 21.40 12.43 45 226934 2596 42391760
Blood lactic acid increased 21.40 12.43 8 226971 8031 42386325
Hypotonia 21.33 12.43 12 226967 9487 42384869
Hodgkin's disease stage II 21.32 12.43 6 226973 6 42394350
Overgrowth bacterial 21.31 12.43 12 226967 138 42394218
Atypical mycobacterial infection 21.21 12.43 31 226948 1335 42393021
Pemphigoid 21.08 12.43 18 226961 11449 42382907
Benign prostatic hyperplasia 20.95 12.43 51 226928 21001 42373355
Stenosis 20.89 12.43 39 226940 2062 42392294
Pharyngeal paraesthesia 20.89 12.43 25 226954 884 42393472
Acute pulmonary oedema 20.80 12.43 10 226969 8641 42385715
Methaemoglobinaemia 20.77 12.43 3 226976 5771 42388585
Catatonia 20.76 12.43 4 226975 6235 42388121
Antibody test abnormal 20.76 12.43 16 226963 322 42394034
Gingival pain 20.73 12.43 95 226884 8399 42385957
Atrioventricular block complete 20.70 12.43 18 226961 11346 42383010
Fistula of small intestine 20.65 12.43 21 226958 617 42393739
Gastrointestinal tract irritation 20.63 12.43 16 226963 325 42394031
Blood glucose abnormal 20.56 12.43 6 226973 7047 42387309
Gastrointestinal cancer metastatic 20.55 12.43 10 226969 83 42394273
Acute graft versus host disease 20.52 12.43 9 226970 8206 42386150
Post procedural discharge 20.51 12.43 16 226963 328 42394028
Myelodysplastic syndrome 20.43 12.43 58 226921 22687 42371669
Low birth weight baby 20.38 12.43 14 226965 9941 42384415
Lip neoplasm malignant stage unspecified 20.34 12.43 7 226972 20 42394336
Lip and/or oral cavity cancer 20.28 12.43 18 226961 444 42393912
Blood pressure diastolic abnormal 20.24 12.43 4 226975 6124 42388232
Skin plaque 20.23 12.43 73 226906 5790 42388566
Granuloma skin 20.22 12.43 28 226951 1147 42393209
Immune thrombocytopenia 20.14 12.43 18 226961 11198 42383158
Lung disorder 20.06 12.43 161 226818 47762 42346594
Bundle branch block right 20.06 12.43 9 226970 8097 42386259
Stomatitis 20.01 12.43 378 226601 49951 42344405
Cystitis escherichia 20.01 12.43 13 226966 197 42394159
Polyomavirus-associated nephropathy 20.01 12.43 3 226976 5612 42388744
Laryngeal neoplasm 19.97 12.43 8 226971 39 42394317
Device occlusion 19.96 12.43 10 226969 8440 42385916
Stoma site abscess 19.91 12.43 9 226970 62 42394294
Anaphylactoid reaction 19.87 12.43 47 226932 2936 42391420
Ventricular hypokinesia 19.80 12.43 6 226973 6878 42387478
Laryngeal cancer 19.80 12.43 22 226957 717 42393639
Bladder cancer 19.79 12.43 157 226822 16890 42377466
Osteoarthritis 19.79 12.43 208 226771 24197 42370159
Vaccination complication 19.79 12.43 9 226970 63 42394293
Drug clearance increased 19.73 12.43 11 226968 124 42394232
Thymus disorder 19.63 12.43 14 226965 249 42394107
Road traffic accident 19.58 12.43 171 226808 18922 42375434
Enterocolonic fistula 19.58 12.43 10 226969 93 42394263
Blood loss anaemia 19.52 12.43 14 226965 9722 42384634
Wound 19.52 12.43 157 226822 16960 42377396
Mood altered 19.49 12.43 17 226962 10701 42383655
Dialysis 19.49 12.43 21 226958 11965 42382391
Myeloid leukaemia 19.44 12.43 18 226961 470 42393886
Duodenal ulcer 19.43 12.43 22 226957 12257 42382099
Liver injury 19.36 12.43 46 226933 19102 42375254
Haemodynamic instability 19.33 12.43 23 226956 12534 42381822
Infusion site pain 19.32 12.43 68 226911 5327 42389029
Hospitalisation 19.28 12.43 279 226700 74051 42320305
Fear 19.21 12.43 18 226961 10947 42383409
Obsessive-compulsive disorder 19.18 12.43 6 226973 6737 42387619
Respiratory acidosis 19.18 12.43 5 226974 6326 42388030
Tuberculosis of central nervous system 19.14 12.43 13 226966 213 42394143
Inadequate diet 19.06 12.43 11 226968 133 42394223
Upper limb fracture 19.02 12.43 69 226910 5487 42388869
Partial seizures 18.99 12.43 4 226975 5855 42388501
Abnormal faeces 18.98 12.43 55 226924 3886 42390470
Red blood cell sedimentation rate 18.98 12.43 26 226953 1054 42393302
Nasopharyngeal cancer 18.92 12.43 11 226968 135 42394221
Scleral discolouration 18.92 12.43 15 226964 315 42394041
Ileocolectomy 18.92 12.43 6 226973 12 42394344
Cortical dysplasia 18.87 12.43 5 226974 3 42394353
Dementia 18.81 12.43 37 226942 16443 42377913
Hypercapnia 18.79 12.43 3 226976 5358 42388998
Endodontic procedure 18.74 12.43 19 226960 556 42393800
Complications of transplanted kidney 18.74 12.43 3 226976 5347 42389009
Protein urine present 18.72 12.43 4 226975 5797 42388559
Mineral supplementation 18.71 12.43 10 226969 103 42394253
Neoplasm skin 18.66 12.43 26 226953 1071 42393285
Intercepted product preparation error 18.61 12.43 8 226971 7381 42386975
Blood pressure decreased 18.57 12.43 424 226555 57908 42336448
Phototherapy 18.57 12.43 7 226972 28 42394328
Hypercalcaemia 18.56 12.43 43 226936 18015 42376341
Ileal ulcer 18.54 12.43 24 226955 920 42393436
Amnesia 18.54 12.43 83 226896 28354 42366002
Groin abscess 18.53 12.43 23 226956 845 42393511
Mycobacterium tuberculosis complex test positive 18.48 12.43 31 226948 1505 42392851
Discharge 18.47 12.43 19 226960 566 42393790
Pulmonary function test decreased 18.40 12.43 4 226975 5728 42388628
Embolism 18.37 12.43 12 226967 8751 42385605
Cryptitis 18.36 12.43 14 226965 277 42394079
Metabolic encephalopathy 18.34 12.43 3 226976 5262 42389094
Disseminated aspergillosis 18.32 12.43 33 226946 1697 42392659
Adhesiolysis 18.29 12.43 6 226973 14 42394342
Infusion related hypersensitivity reaction 18.29 12.43 13 226966 230 42394126
Deafness 18.24 12.43 26 226953 13114 42381242
Gout 18.22 12.43 82 226897 27973 42366383
Allergic fungal rhinosinusitis 18.21 12.43 8 226971 51 42394305
Cholangiocarcinoma 18.20 12.43 32 226947 1614 42392742
Spleen tuberculosis 18.19 12.43 7 226972 30 42394326
Hemiparesis 18.17 12.43 41 226938 17335 42377021
Epstein-Barr virus infection reactivation 18.16 12.43 42 226937 2585 42391771
Spinal cord injury cervical 18.15 12.43 14 226965 282 42394074
Gallbladder operation 18.15 12.43 19 226960 578 42393778
Tympanic membrane perforation 18.13 12.43 17 226962 451 42393905
Gastritis erosive 18.12 12.43 6 226973 6497 42387859
Ingrown hair 18.07 12.43 12 226967 189 42394167
Hypoxic-ischaemic encephalopathy 18.04 12.43 3 226976 5199 42389157
Parosmia 18.02 12.43 85 226894 7606 42386750
Anti-saccharomyces cerevisiae antibody 18.01 12.43 6 226973 15 42394341
Peripheral arterial occlusive disease 17.87 12.43 7 226972 6831 42387525
Escherichia bacteraemia 17.78 12.43 3 226976 5146 42389210
Intestinal adenocarcinoma 17.78 12.43 9 226970 82 42394274
Dermatitis atopic 17.76 12.43 24 226955 12380 42381976
Lipase increased 17.76 12.43 18 226961 10548 42383808
Myocardial ischaemia 17.70 12.43 43 226936 17719 42376637
Anal fistula infection 17.66 12.43 7 226972 33 42394323
Oesophageal adenocarcinoma 17.65 12.43 24 226955 966 42393390
Sexual dysfunction 17.60 12.43 7 226972 6768 42387588
Protein total decreased 17.57 12.43 5 226974 5971 42388385
Blindness 17.54 12.43 44 226935 17934 42376422
T-cell lymphoma refractory 17.49 12.43 7 226972 34 42394322
Anorectal stenosis 17.47 12.43 6 226973 17 42394339
Foreign body in eye 17.38 12.43 11 226968 159 42394197
Cutaneous nocardiosis 17.19 12.43 12 226967 206 42394150
Disseminated varicella zoster virus infection 17.16 12.43 21 226958 760 42393596
Cholecystectomy 17.14 12.43 48 226931 3326 42391030
Haemophagocytic lymphohistiocytosis 17.06 12.43 160 226819 18062 42376294
Mouth haemorrhage 17.05 12.43 6 226973 6255 42388101
Rectal discharge 17.00 12.43 14 226965 311 42394045
Anal dilation procedure 16.96 12.43 4 226975 0 42394356
Anal neoplasm 16.96 12.43 4 226975 0 42394356
Benign renal neoplasm 16.96 12.43 4 226975 0 42394356
Hepatic echinococciasis 16.96 12.43 4 226975 0 42394356
Amyotrophic lateral sclerosis 16.93 12.43 25 226954 1087 42393269
Urosepsis 16.91 12.43 34 226945 14986 42379370
Leishmaniasis 16.90 12.43 16 226963 430 42393926
Ingrowing nail 16.89 12.43 25 226954 1089 42393267
Subileus 16.82 12.43 49 226930 3472 42390884
Emotional distress 16.80 12.43 38 226941 16055 42378301
Gastrooesophageal reflux disease 16.73 12.43 156 226823 44867 42349489
Angiolymphoid hyperplasia with eosinophilia 16.71 12.43 10 226969 130 42394226
Accident at work 16.68 12.43 23 226956 938 42393418
Basosquamous carcinoma 16.65 12.43 9 226970 95 42394261
Ear neoplasm 16.58 12.43 8 226971 65 42394291
Rash 16.58 12.43 1260 225719 275694 42118662
Eye inflammation 16.56 12.43 46 226933 3172 42391184
Accidental overdose 16.54 12.43 86 226893 28244 42366112
Serum ferritin decreased 16.53 12.43 23 226956 946 42393410
Perineal fistula 16.53 12.43 6 226973 21 42394335
Scleral hyperaemia 16.48 12.43 8 226971 66 42394290
Metastatic malignant melanoma 16.47 12.43 38 226941 2335 42392021
Oesophageal fibrosis 16.47 12.43 11 226968 175 42394181
Pathological fracture 16.38 12.43 4 226975 5289 42389067
Stress at work 16.36 12.43 13 226966 274 42394082
Abscess rupture 16.28 12.43 8 226971 68 42394288
Muscle spasticity 16.23 12.43 8 226971 6814 42387542
Gastrointestinal scarring 16.21 12.43 11 226968 180 42394176
Tonsillitis bacterial 16.15 12.43 7 226972 43 42394313
Tonsil cancer 16.11 12.43 25 226954 1136 42393220
Fear of injection 16.08 12.43 34 226945 1969 42392387
Epstein-Barr virus test positive 16.03 12.43 19 226960 665 42393691
Infection 15.99 12.43 740 226239 111328 42283028
Oral pustule 15.98 12.43 12 226967 232 42394124
Anal ulcer 15.95 12.43 25 226954 1146 42393210
Throat cancer 15.95 12.43 28 226951 1411 42392945
Dyslipidaemia 15.88 12.43 16 226963 9402 42384954
Bile duct cancer 15.83 12.43 19 226960 674 42393682
Peripheral sensory neuropathy 15.81 12.43 14 226965 8748 42385608
Injection site bruising 15.80 12.43 23 226956 11502 42382854
Bone pain 15.78 12.43 69 226910 23723 42370633
Histone antibody positive 15.76 12.43 5 226974 10 42394346
Performance status decreased 15.76 12.43 3 226976 4717 42389639
Diffuse large B-cell lymphoma stage IV 15.75 12.43 17 226962 536 42393820
Pharyngeal neoplasm 15.72 12.43 6 226973 25 42394331
Rheumatoid factor 15.70 12.43 8 226971 74 42394282
Neurological symptom 15.70 12.43 18 226961 9973 42384383
Prescribed overdose 15.66 12.43 28 226951 12899 42381457
Blood test abnormal 15.59 12.43 28 226951 12878 42381478
Polyp 15.54 12.43 57 226922 4557 42389799
Muscle abscess 15.50 12.43 22 226957 922 42393434
Ammonia increased 15.47 12.43 3 226976 4656 42389700
Cytomegalovirus enterocolitis 15.44 12.43 27 226952 1356 42393000
Hypovolaemic shock 15.43 12.43 14 226965 8645 42385711
Precancerous cells present 15.39 12.43 7 226972 49 42394307
Pulmonary haemorrhage 15.38 12.43 23 226956 11374 42382982
Haemolysis 15.37 12.43 17 226962 9572 42384784
Brain injury 15.36 12.43 11 226968 7644 42386712
Pancreatitis acute 15.35 12.43 110 226869 33454 42360902
Ileus paralytic 15.30 12.43 11 226968 7630 42386726
Neuroendocrine carcinoma of the skin 15.27 12.43 22 226957 935 42393421
Testicular mass 15.25 12.43 10 226969 154 42394202
Double stranded DNA antibody positive 15.22 12.43 11 226968 200 42394156
Rectal fissure 15.20 12.43 14 226965 363 42393993
Ileocolostomy 15.19 12.43 6 226973 28 42394328
Carotid artery stenosis 15.17 12.43 5 226974 5431 42388925
Dysphonia 15.17 12.43 89 226890 28361 42365995
Nasal turbinate abnormality 15.15 12.43 7 226972 51 42394305
Incarcerated parastomal hernia 15.15 12.43 5 226974 12 42394344
Anorectal swelling 15.15 12.43 5 226974 12 42394344
Hepatitis B reactivation 15.10 12.43 3 226976 4575 42389781
Duodenal ulcer haemorrhage 15.09 12.43 6 226973 5802 42388554
Salmonella sepsis 15.09 12.43 10 226969 157 42394199
Arthrodesis 15.06 12.43 17 226962 564 42393792
Intestinal tuberculosis 15.03 12.43 10 226969 158 42394198
Chronic recurrent multifocal osteomyelitis 15.02 12.43 6 226973 29 42394327
Hydronephrosis 15.01 12.43 25 226954 11840 42382516
Supraventricular tachycardia 14.92 12.43 27 226952 12381 42381975
Angiopathy 14.91 12.43 5 226974 5372 42388984
Hepatitis fulminant 14.86 12.43 4 226975 4955 42389401
Colon cancer metastatic 14.85 12.43 30 226949 1682 42392674
Hand deformity 14.81 12.43 49 226930 3719 42390637
Mononeuropathy multiplex 14.81 12.43 16 226963 505 42393851
Prerenal failure 14.78 12.43 37 226942 2396 42391960
Therapeutic product effect delayed 14.78 12.43 28 226951 1497 42392859
Pertussis 14.77 12.43 15 226964 440 42393916
Growth disorder 14.75 12.43 8 226971 85 42394271
Malignant respiratory tract neoplasm 14.74 12.43 4 226975 3 42394353
Gliomatosis cerebri 14.74 12.43 4 226975 3 42394353
Staphylococcus test 14.74 12.43 4 226975 3 42394353
Large intestine operation 14.74 12.43 4 226975 3 42394353
Lung cancer metastatic 14.70 12.43 42 226937 2944 42391412
Metastases to bone 14.64 12.43 36 226943 14773 42379583
Dizziness postural 14.62 12.43 12 226967 7783 42386573
Mixed liver injury 14.61 12.43 3 226976 4471 42389885
Lymphadenitis bacterial 14.60 12.43 7 226972 56 42394300
Acute respiratory distress syndrome 14.60 12.43 97 226882 30011 42364345
Cyanosis 14.58 12.43 133 226846 14898 42379458
Spondyloarthropathy 14.57 12.43 21 226958 893 42393463
Blood thyroid stimulating hormone increased 14.54 12.43 5 226974 5287 42389069
Adverse event 14.52 12.43 191 226788 23449 42370907
Gastrointestinal wall thickening 14.52 12.43 31 226948 1808 42392548
Meningitis tuberculous 14.51 12.43 18 226961 661 42393695
Blood glucose decreased 14.50 12.43 34 226945 14185 42380171
Drug level increased 14.49 12.43 81 226898 26119 42368237
Squamous cell carcinoma of lung 14.44 12.43 35 226944 2221 42392135
Angiocentric lymphoma 14.41 12.43 16 226963 521 42393835
Liver function test abnormal 14.41 12.43 107 226872 32284 42362072
Amylase increased 14.40 12.43 9 226970 6720 42387636
Cerebral haematoma 14.25 12.43 6 226973 5604 42388752
Product complaint 14.23 12.43 7 226972 5970 42388386
Ventricular hypertrophy 14.22 12.43 4 226975 4812 42389544
Linitis plastica 14.21 12.43 4 226975 4 42394352
Keratomileusis 14.21 12.43 4 226975 4 42394352
Varicella post vaccine 14.21 12.43 4 226975 4 42394352
Septic pulmonary embolism 14.16 12.43 9 226970 131 42394225
Radial nerve palsy 14.14 12.43 8 226971 93 42394263
Abscess limb 14.12 12.43 51 226928 4046 42390310
Abdominal hernia 14.10 12.43 42 226937 3013 42391343
Azotaemia 14.09 12.43 7 226972 5937 42388419
Hyperhidrosis 14.08 12.43 603 226376 89909 42304447
Electrocardiogram ST segment elevation 14.07 12.43 7 226972 5932 42388424
Disseminated intravascular coagulation 14.07 12.43 76 226903 24718 42369638
Furuncle 14.07 12.43 48 226931 3702 42390654
Acute generalised exanthematous pustulosis 14.04 12.43 15 226964 8580 42385776
Infusion site swelling 14.02 12.43 44 226935 3248 42391108
Ventricular arrhythmia 14.00 12.43 8 226971 6271 42388085
Product administered to patient of inappropriate age 13.97 12.43 4 226975 4757 42389599
Localised infection 13.96 12.43 168 226811 20205 42374151
Faecaloma 13.96 12.43 8 226971 6262 42388094
Viral infection 13.95 12.43 182 226797 22301 42372055
Herpes ophthalmic 13.93 12.43 18 226961 689 42393667
Urethral polyp 13.90 12.43 7 226972 63 42394293
Omphalitis 13.89 12.43 5 226974 17 42394339
Ligament operation 13.89 12.43 5 226974 17 42394339
Meniscus operation 13.89 12.43 5 226974 17 42394339
Narcotic bowel syndrome 13.87 12.43 9 226970 136 42394220
Metastases to central nervous system 13.87 12.43 21 226958 10334 42384022
Multifocal motor neuropathy 13.82 12.43 9 226970 137 42394219
Hordeolum 13.81 12.43 28 226951 1574 42392782
Dyshidrotic eczema 13.78 12.43 10 226969 183 42394173
Cytomegalovirus infection reactivation 13.73 12.43 24 226955 11154 42383202
Staphylococcal skin infection 13.71 12.43 22 226957 1029 42393327
Colitis ischaemic 13.71 12.43 11 226968 7215 42387141
Rhinovirus infection 13.68 12.43 9 226970 6539 42387817
Wrist deformity 13.68 12.43 13 226966 351 42394005
Pulmonary sarcoidosis 13.67 12.43 19 226960 781 42393575
Rheumatoid nodule 13.66 12.43 41 226938 2954 42391402
Lung opacity 13.65 12.43 7 226972 5830 42388526
Gingival bleeding 13.65 12.43 15 226964 8470 42385886
Intestinal ischaemia 13.61 12.43 18 226961 9370 42384986
Incorrect dosage administered 13.61 12.43 29 226950 1689 42392667
Oesophagitis 13.60 12.43 39 226940 15208 42379148
Heart rate abnormal 13.55 12.43 34 226945 2205 42392151
Bowen's disease 13.54 12.43 9 226970 142 42394214
Thyroiditis subacute 13.53 12.43 7 226972 67 42394289
Rales 13.53 12.43 25 226954 11375 42382981
Psychiatric symptom 13.53 12.43 3 226976 4238 42390118
Eye infection bacterial 13.50 12.43 8 226971 102 42394254
Apnoea 13.45 12.43 13 226966 7790 42386566
Jejunal stenosis 13.45 12.43 7 226972 68 42394288
Abdominal operation 13.43 12.43 9 226970 144 42394212
Dysgeusia 13.34 12.43 117 226862 34072 42360284
Nystagmus 13.34 12.43 6 226973 5390 42388966
Abdominal adhesions 13.33 12.43 29 226950 1713 42392643
Anti-platelet antibody 13.33 12.43 4 226975 6 42394350
Small intestine operation 13.33 12.43 4 226975 6 42394350
Biopsy skin 13.33 12.43 4 226975 6 42394350
Small intestine carcinoma metastatic 13.33 12.43 4 226975 6 42394350
Wound infection 13.29 12.43 83 226896 8263 42386093
Exposure to communicable disease 13.28 12.43 10 226969 194 42394162
Sarcoma 13.26 12.43 14 226965 430 42393926
Ear operation 13.26 12.43 5 226974 20 42394336
Food poisoning 13.26 12.43 38 226941 2668 42391688
Prostatic specific antigen increased 13.20 12.43 46 226933 16879 42377477
Lewis-Sumner syndrome 13.19 12.43 7 226972 71 42394285
Tooth hypoplasia 13.18 12.43 11 226968 249 42394107
Cardiomyopathy 13.17 12.43 55 226924 19155 42375201
Injection site rash 13.14 12.43 7 226972 5705 42388651
Rash morbilliform 13.12 12.43 3 226976 4150 42390206
Oropharyngeal cancer 13.10 12.43 7 226972 72 42394284
Transaminases increased 13.07 12.43 112 226867 32773 42361583
Lymphoedema 13.04 12.43 5 226974 4943 42389413
Dyspepsia 13.02 12.43 149 226830 41203 42353153
Keratoacanthoma 12.97 12.43 20 226959 904 42393452
Small cell lung cancer extensive stage 12.95 12.43 4 226975 7 42394349
Inflammation of lacrimal passage 12.95 12.43 4 226975 7 42394349
Pulmonary granuloma 12.93 12.43 28 226951 1649 42392707
Probiotic therapy 12.92 12.43 9 226970 154 42394202
Cataract 12.91 12.43 232 226747 30372 42363984
Injection site mass 12.89 12.43 16 226963 8559 42385797
Eye infection toxoplasmal 12.87 12.43 12 226967 316 42394040
Renal tubular disorder 12.87 12.43 5 226974 4904 42389452
Wound infection bacterial 12.81 12.43 12 226967 318 42394038
Iridocyclitis 12.78 12.43 33 226946 2178 42392178
Enteritis 12.77 12.43 100 226879 10716 42383640
Infective glossitis 12.72 12.43 3 226976 0 42394356
Malignant melanoma of sites other than skin 12.72 12.43 3 226976 0 42394356
Hodgkin's disease stage IV 12.72 12.43 3 226976 0 42394356
Aneurysmal bone cyst 12.72 12.43 3 226976 0 42394356
Nephroblastoma 12.72 12.43 3 226976 0 42394356
Gingival operation 12.72 12.43 3 226976 0 42394356
Laryngitis viral 12.72 12.43 3 226976 0 42394356
Prostate ablation 12.72 12.43 3 226976 0 42394356
Intestinal transit time increased 12.72 12.43 3 226976 0 42394356
Stoma site rash 12.72 12.43 3 226976 0 42394356
Anal fistula repair 12.72 12.43 3 226976 0 42394356
Cytomegalovirus mononucleosis 12.72 12.43 3 226976 0 42394356
Lupus pleurisy 12.72 12.43 3 226976 0 42394356
Splenitis 12.72 12.43 3 226976 0 42394356
Epithelioid sarcoma 12.72 12.43 3 226976 0 42394356
Jejunectomy 12.72 12.43 3 226976 0 42394356
Exploratory operation 12.72 12.43 3 226976 0 42394356
Dientamoeba infection 12.72 12.43 3 226976 0 42394356
Brain neoplasm benign 12.71 12.43 5 226974 23 42394333
Blood pressure abnormal 12.71 12.43 21 226958 9977 42384379
Haemothorax 12.67 12.43 6 226973 5230 42389126
Intestinal intraepithelial lymphocytes increased 12.65 12.43 10 226969 209 42394147
Transplant failure 12.62 12.43 3 226976 4041 42390315
Coronary artery aneurysm 12.62 12.43 8 226971 116 42394240
Nephritis bacterial 12.61 12.43 4 226975 8 42394348
Cyclic neutropenia 12.61 12.43 4 226975 8 42394348
Lower gastrointestinal haemorrhage 12.57 12.43 24 226955 10784 42383572
Neuroendocrine carcinoma 12.56 12.43 15 226964 529 42393827
Osteosarcoma recurrent 12.56 12.43 8 226971 117 42394239
Peritonitis bacterial 12.54 12.43 11 226968 6904 42387452
Tendonitis 12.53 12.43 93 226886 9801 42384555
Eyelid infection 12.52 12.43 6 226973 48 42394308
Biopsy 12.48 12.43 12 226967 329 42394027

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 8852.95 11.80 26846 755517 1473339 108333597
Intentional product use issue 8278.14 11.80 9462 772901 238444 109568492
Infusion related reaction 5623.23 11.80 9837 772526 371325 109435611
Inappropriate schedule of product administration 5073.46 11.80 6711 775652 196926 109610010
Condition aggravated 4873.70 11.80 13754 768609 721082 109085854
Product use issue 4035.36 11.80 7606 774757 304089 109502847
Acute kidney injury 2949.68 11.80 481 781882 634949 109171987
Toxicity to various agents 2898.76 11.80 116 782247 480439 109326497
Drug interaction 2519.85 11.80 294 782069 499889 109307047
Death 2266.14 11.80 1057 781306 697812 109109124
Drug level below therapeutic 2028.26 11.80 1175 781188 10498 109796438
Blood pressure fluctuation 2016.35 11.80 2566 779797 72258 109734678
Drug ineffective 1906.59 11.80 17707 764656 1502833 108304103
Treatment failure 1837.33 11.80 5199 777164 272035 109534901
Febrile neutropenia 1784.37 11.80 116 782247 316651 109490285
Synovitis 1765.72 11.80 5088 777275 269004 109537932
Arthralgia 1695.12 11.80 10350 772013 769282 109037654
Neutropenia 1682.85 11.80 308 782055 374312 109432624
Drug specific antibody present 1635.04 11.80 912 781451 7522 109799414
Drug intolerance 1564.26 11.80 6351 776012 400161 109406775
Drug level decreased 1556.89 11.80 1186 781177 17362 109789574
Intestinal resection 1551.01 11.80 689 781674 3240 109803696
Haematochezia 1519.85 11.80 2842 779521 112682 109694254
Contraindicated product administered 1518.61 11.80 4525 777838 243742 109563194
Anaemia 1514.17 11.80 1006 781357 546080 109260856
Therapeutic product effect decreased 1511.52 11.80 4471 777892 239845 109567091
Completed suicide 1496.86 11.80 48 782315 242333 109564603
Weight increased 1470.93 11.80 6372 775991 413272 109393664
Fistula 1458.33 11.80 1056 781307 14243 109792693
Systemic lupus erythematosus 1318.44 11.80 4378 777985 249960 109556976
Arthropathy 1288.47 11.80 4716 777647 282806 109524130
Joint swelling 1283.62 11.80 6361 776002 436484 109370452
Faecal calprotectin increased 1233.25 11.80 701 781662 6018 109800918
Anal fissure 1222.69 11.80 801 781562 9080 109797856
Frequent bowel movements 1189.35 11.80 1949 780414 69441 109737495
Drug abuse 1157.45 11.80 19 782344 177392 109629544
Hyponatraemia 1107.22 11.80 123 782240 217530 109589406
Therapeutic response shortened 1103.82 11.80 1199 781164 28384 109778552
Hypotension 1072.20 11.80 1277 781086 522572 109284364
Hand deformity 1067.59 11.80 3688 778675 214818 109592118
Lupus-like syndrome 1025.28 11.80 1352 781011 39440 109767496
Fall 1019.29 11.80 1688 780675 601794 109205142
Pemphigus 990.86 11.80 3555 778808 211015 109595921
Glossodynia 987.85 11.80 3634 778729 218370 109588566
Disease progression 958.68 11.80 269 782094 243765 109563171
Alopecia 953.57 11.80 5092 777271 359661 109447275
Malignant neoplasm progression 947.94 11.80 76 782287 174491 109632445
Cardiac arrest 938.31 11.80 137 782226 196616 109610320
Thrombocytopenia 934.47 11.80 664 781699 348221 109458715
Anti-cyclic citrullinated peptide antibody positive 917.18 11.80 3104 779259 178880 109628056
Platelet count decreased 908.98 11.80 252 782111 230191 109576745
Hypersensitivity 853.04 11.80 5329 777034 398669 109408267
Skin cancer 831.99 11.80 814 781549 16970 109789966
Intentional overdose 825.95 11.80 24 782339 132477 109674459
Pancytopenia 821.54 11.80 232 782131 209381 109597555
Anal fistula 817.01 11.80 589 781774 7884 109799052
Hyperkalaemia 816.99 11.80 33 782330 135763 109671173
White blood cell count decreased 814.12 11.80 302 782061 229088 109577848
Disseminated tuberculosis 810 11.80 486 781877 4660 109802276
Wound 807.86 11.80 3544 778819 230893 109576043
Pericarditis 804.78 11.80 3377 778986 215737 109591199
Somnolence 795.26 11.80 567 781796 296882 109510054
Atrial fibrillation 782.54 11.80 322 782041 229320 109577616
Tuberculosis 782.38 11.80 787 781576 16987 109789949
Heart rate decreased 776.80 11.80 1772 780591 80984 109725952
Uveitis 771.95 11.80 858 781505 20852 109786084
Anal abscess 748.83 11.80 637 781726 11001 109795935
Rheumatoid factor positive 715.54 11.80 2304 780059 129336 109677600
Pulmonary tuberculosis 696.57 11.80 552 781811 8587 109798349
Cardiac failure 693.22 11.80 231 782132 187395 109619541
Electrocardiogram QT prolonged 689.36 11.80 17 782346 108943 109697993
Seizure 678.19 11.80 359 782004 220826 109586110
Poor venous access 672.98 11.80 849 781514 23673 109783263
Rhabdomyolysis 657.60 11.80 51 782312 120350 109686586
Neuropathy peripheral 654.89 11.80 225 782138 179052 109627884
Abscess 643.75 11.80 880 781483 26589 109780347
Blood creatinine increased 640.18 11.80 246 782117 182643 109624293
Hepatic enzyme increased 638.73 11.80 4171 778192 316721 109490215
Neutrophil count decreased 633.90 11.80 61 782302 120880 109686056
C-reactive protein abnormal 630.33 11.80 2186 780177 127509 109679427
Cardiac failure congestive 626.28 11.80 149 782214 150851 109656085
Helicobacter infection 622.21 11.80 2744 779619 179133 109627803
Colectomy 618.83 11.80 386 781977 3992 109802944
Hypoglycaemia 615.36 11.80 56 782307 116048 109690888
Swelling 613.96 11.80 4420 777943 346621 109460315
Cardio-respiratory arrest 613.59 11.80 56 782307 115780 109691156
Abdominal discomfort 609.47 11.80 4818 777545 389040 109417896
Coma 590.81 11.80 70 782293 117799 109689137
Hypokalaemia 580.44 11.80 282 782081 182166 109624770
Duodenal ulcer perforation 577.83 11.80 2641 779722 175059 109631877
Inflammation 573.70 11.80 2797 779566 190441 109616495
Injection site pain 573.69 11.80 270 782093 177652 109629284
Pyoderma gangrenosum 556.38 11.80 393 781970 5083 109801853
Metabolic acidosis 554.00 11.80 39 782324 99705 109707231
Drug level above therapeutic 546.92 11.80 533 781830 11055 109795881
Gastrointestinal haemorrhage 541.68 11.80 246 782117 165272 109641664
Musculoskeletal stiffness 539.64 11.80 3609 778754 276213 109530723
Bradycardia 537.97 11.80 213 782150 155304 109651632
Hallucination 532.02 11.80 51 782312 101381 109705555
Intestinal stenosis 527.44 11.80 359 782004 4356 109802580
Lactic acidosis 525.15 11.80 33 782330 92778 109714158
Depressed level of consciousness 521.91 11.80 84 782279 112194 109694742
Respiratory failure 516.87 11.80 457 781906 214875 109592061
Renal failure 515.39 11.80 505 781858 226069 109580867
Folliculitis 510.81 11.80 2445 779918 165208 109641728
Discomfort 503.39 11.80 2912 779451 211795 109595141
Incorrect dose administered 502.79 11.80 1746 780617 101895 109705041
Renal impairment 493.34 11.80 367 781996 188078 109618858
Hypoxia 491.57 11.80 152 782211 129363 109677573
Psoriasis 486.22 11.80 2122 780241 137871 109669065
International normalised ratio increased 470.36 11.80 38 782325 86734 109720202
Dehydration 463.47 11.80 790 781573 278721 109528215
Basal cell carcinoma 460.31 11.80 1001 781362 44269 109762667
Hyperglycaemia 459.19 11.80 38 782325 85052 109721884
Clostridium difficile infection 456.04 11.80 1086 781277 51043 109755893
Irritable bowel syndrome 454.18 11.80 2330 780033 161885 109645051
Cytokine release syndrome 452.42 11.80 9 782354 70297 109736639
Sedation 452.15 11.80 8 782355 69675 109737261
Drug specific antibody 450.08 11.80 269 782094 2559 109804377
Sleep disorder due to general medical condition, insomnia type 450.00 11.80 1706 780657 103937 109702999
Heart rate irregular 447.66 11.80 841 781522 33433 109773503
Red blood cell sedimentation rate increased 446.87 11.80 1394 780969 76908 109730028
Myelosuppression 442.06 11.80 69 782294 94271 109712665
Therapeutic product effect incomplete 440.09 11.80 2901 779462 220904 109586032
Acne 438.43 11.80 823 781540 32697 109774239
Psoriatic arthropathy 437.59 11.80 2632 779731 194129 109612807
Drug reaction with eosinophilia and systemic symptoms 433.95 11.80 40 782323 82055 109724881
Blood glucose increased 433.40 11.80 197 782166 132299 109674637
Constipation 427.01 11.80 1213 781150 356573 109450363
Suicide attempt 422.90 11.80 105 782258 103289 109703647
Mucosal inflammation 420.69 11.80 84 782279 96057 109710879
C-reactive protein increased 419.00 11.80 2809 779554 215110 109591826
Maternal exposure during pregnancy 412.70 11.80 3152 779211 251731 109555205
Transplant dysfunction 411.78 11.80 393 781970 7935 109799001
Balance disorder 409.14 11.80 156 782207 116404 109690532
Multiple organ dysfunction syndrome 406.80 11.80 288 782075 151422 109655514
Ovarian cyst 399.36 11.80 493 781870 13437 109793499
Mucous stools 398.60 11.80 354 782009 6493 109800443
Muscle injury 388.72 11.80 1997 780366 138810 109668126
Red blood cell sedimentation rate abnormal 383.79 11.80 651 781712 23858 109783078
Impaired healing 383.14 11.80 2544 779819 194173 109612763
Serotonin syndrome 382.95 11.80 7 782356 59146 109747790
Mental status changes 381.98 11.80 45 782318 76077 109730859
Agitation 374.60 11.80 165 782198 112886 109694050
Erythema nodosum 365.66 11.80 333 782030 6320 109800616
Cognitive disorder 365.50 11.80 85 782278 87426 109719510
Encephalopathy 364.90 11.80 66 782297 80989 109725947
Flushing 359.36 11.80 1582 780781 103154 109703782
Pneumonia aspiration 355.37 11.80 71 782292 81162 109725774
Product dose omission issue 353.74 11.80 1133 781230 320649 109486287
Dysarthria 352.74 11.80 81 782282 84040 109722896
Injection site erythema 351.18 11.80 114 782249 94062 109712874
Sepsis 349.88 11.80 1167 781196 326179 109480757
Disorientation 346.74 11.80 45 782318 70626 109736310
Acute myocardial infarction 346.68 11.80 83 782280 83694 109723242
Neoplasm progression 345.39 11.80 30 782333 64565 109742371
Histoplasmosis disseminated 344.21 11.80 257 782106 3642 109803294
Arthritis 343.86 11.80 2196 780167 165390 109641546
Oedema peripheral 342.90 11.80 1184 781179 327476 109479460
Loss of personal independence in daily activities 340.02 11.80 2017 780346 148003 109658933
Pulmonary oedema 339.75 11.80 143 782220 100516 109706420
Rheumatic fever 339.39 11.80 1740 780623 120839 109686097
Exposure during pregnancy 337.44 11.80 2184 780179 165240 109641696
Ascites 334.51 11.80 119 782244 92689 109714247
Hypomagnesaemia 334.10 11.80 24 782339 60346 109746590
Drug hypersensitivity 332.83 11.80 4778 777585 449312 109357624
Chronic obstructive pulmonary disease 330.32 11.80 180 782183 108978 109697958
Weight decreased 329.68 11.80 4891 777472 463166 109343770
Body temperature fluctuation 329.30 11.80 247 782116 3526 109803410
Dysphagia 329.27 11.80 360 782003 153240 109653696
Aphthous ulcer 329.09 11.80 560 781803 20576 109786360
Haemoglobin decreased 326.47 11.80 804 781559 247923 109559013
Orthostatic hypotension 325.48 11.80 42 782321 66207 109740729
Multiple sclerosis relapse 325.01 11.80 6 782357 50234 109756702
Dyspnoea exertional 320.16 11.80 168 782195 103892 109703044
Blood bilirubin increased 314.90 11.80 75 782288 75897 109731039
Altered state of consciousness 312.98 11.80 25 782338 57601 109749335
COVID-19 311.18 11.80 2870 779493 242190 109564746
Cerebrovascular accident 309.09 11.80 503 781860 180781 109626155
Abdominal pain 307.15 11.80 5217 777146 507772 109299164
Respiratory arrest 306.54 11.80 29 782334 58270 109748666
Incorrect drug administration rate 305.29 11.80 277 782086 5231 109801705
Mobility decreased 304.22 11.80 2786 779577 234636 109572300
Ill-defined disorder 302.07 11.80 2023 780340 154830 109652106
Defaecation urgency 301.20 11.80 340 782023 8407 109798529
Rheumatoid arthritis 299.85 11.80 3341 779022 296272 109510664
Toxic epidermal necrolysis 298.85 11.80 28 782335 56699 109750237
Asthenia 298.22 11.80 3276 779087 685723 109121213
Wrong technique in product usage process 294.94 11.80 124 782239 87224 109719712
Coronary artery disease 294.73 11.80 72 782291 71618 109735318
Agranulocytosis 294.32 11.80 43 782320 61717 109745219
Infection 294.13 11.80 3882 778481 358318 109448618
Full blood count abnormal 291.78 11.80 29 782334 56023 109750913
Blood pressure increased 289.75 11.80 2948 779415 255425 109551511
Urinary retention 288.41 11.80 69 782294 69614 109737322
Hypervolaemia 287.73 11.80 15 782348 49445 109757491
Ileal stenosis 287.47 11.80 215 782148 3055 109803881
Cardiogenic shock 287.44 11.80 34 782329 57304 109749632
Ileostomy 284.02 11.80 189 782174 2203 109804733
Leukopenia 282.69 11.80 383 781980 148408 109658528
Nasopharyngitis 279.17 11.80 4125 778238 390236 109416700
Unresponsive to stimuli 278.52 11.80 56 782307 63734 109743202
Urticaria 278.11 11.80 3463 778900 315394 109491542
Pleural effusion 277.60 11.80 521 781842 177188 109629748
Pain 270.26 11.80 8745 773618 946210 108860726
Blood creatine phosphokinase increased 268.02 11.80 91 782272 72986 109733950
Intentional product misuse 264.95 11.80 330 782033 132574 109674362
Blood urea increased 264.84 11.80 37 782326 54920 109752016
Pulmonary hypertension 264.18 11.80 38 782325 55182 109751754
Plasma cell myeloma 263.08 11.80 61 782302 62875 109744061
Fibromyalgia 261.79 11.80 2087 780276 168822 109638114
Palmar-plantar erythrodysaesthesia syndrome 261.01 11.80 6 782357 41019 109765917
Myocardial infarction 259.86 11.80 611 781752 191472 109615464
Hypothyroidism 258.44 11.80 96 782267 72803 109734133
Upper gastrointestinal haemorrhage 255.40 11.80 28 782335 50068 109756868
Neurotoxicity 254.68 11.80 10 782353 42197 109764739
Dry skin 254.00 11.80 232 782131 107421 109699515
Acute respiratory failure 253.85 11.80 107 782256 75153 109731783
Rash maculo-papular 252.80 11.80 104 782259 74118 109732818
Swollen joint count increased 250.97 11.80 1215 781148 82446 109724490
Syncope 250.13 11.80 675 781688 201861 109605075
Ventricular tachycardia 249.83 11.80 30 782333 49979 109756957
Pneumonia 249.21 11.80 4535 777828 872179 108934757
Cerebral haemorrhage 248.74 11.80 75 782288 64893 109742043
Bone erosion 248.52 11.80 808 781555 45563 109761373
Pulmonary embolism 245.62 11.80 741 781622 213733 109593203
Haemoptysis 244.63 11.80 99 782264 71255 109735681
Urinary tract infection 244.53 11.80 1332 781031 324950 109481986
Large intestinal stenosis 243.39 11.80 207 782156 3573 109803363
Diarrhoea 242.31 11.80 6176 776187 1133329 108673607
Gastrointestinal disorder 238.80 11.80 2691 779672 239261 109567675
Obstructive airways disorder 237.30 11.80 25 782338 46124 109760812
Dyspnoea 236.69 11.80 5994 776369 1100878 108706058
Aggression 236.61 11.80 63 782300 59147 109747789
Exposure to SARS-CoV-2 234.75 11.80 182 782181 2737 109804199
Melaena 233.12 11.80 97 782266 68660 109738276
Ventricular fibrillation 229.84 11.80 16 782347 41297 109765639
Herpes zoster 227.70 11.80 1429 780934 106950 109699986
Dyskinesia 227.06 11.80 44 782319 51402 109755534
Blister 226.70 11.80 2534 779829 224842 109582094
Lymphocyte count decreased 226.69 11.80 62 782301 57181 109749755
Lymph node tuberculosis 226.66 11.80 124 782239 980 109805956
Bone marrow failure 224.73 11.80 65 782298 57783 109749153
Vision blurred 224.61 11.80 353 782010 128669 109678267
Type 2 diabetes mellitus 221.54 11.80 2069 780294 175163 109631773
Diabetic ketoacidosis 220.92 11.80 21 782342 42037 109764899
Haematuria 220.60 11.80 159 782204 82846 109724090
Tremor 220.07 11.80 715 781648 201517 109605419
Infusion site extravasation 217.59 11.80 335 782028 11299 109795637
Skin exfoliation 212.66 11.80 184 782179 87467 109719469
Facet joint syndrome 211.14 11.80 1289 781074 95539 109711397
Gastrointestinal inflammation 210.83 11.80 296 782067 9173 109797763
Suicidal ideation 210.47 11.80 212 782151 93725 109713211
Aphasia 210.30 11.80 77 782286 58920 109748016
Hypophagia 210.28 11.80 56 782307 52570 109754366
Hallucination, visual 210.10 11.80 19 782344 39586 109767350
Hepatic failure 209.93 11.80 112 782251 68627 109738309
Intentional self-injury 209.67 11.80 14 782349 37415 109769521
Disturbance in attention 209.32 11.80 88 782275 61907 109745029
Eosinophilia 209.27 11.80 74 782289 57862 109749074
Haematoma 208.99 11.80 76 782287 58400 109748536
Blood alkaline phosphatase increased 205.97 11.80 123 782240 70812 109736124
Device expulsion 202.70 11.80 3 782360 30888 109776048
Intestinal obstruction 201.90 11.80 829 781534 52398 109754538
Stevens-Johnson syndrome 200.99 11.80 43 782320 46858 109760078
Lower respiratory tract infection 200.70 11.80 2614 779749 240492 109566444
Full blood count decreased 199.31 11.80 6 782357 32093 109774843
Lethargy 198.67 11.80 221 782142 93355 109713581
Drug withdrawal syndrome 197.26 11.80 20 782343 38034 109768902
Cholestasis 197.22 11.80 105 782258 64413 109742523
Histoplasmosis 196.90 11.80 165 782198 2788 109804148
Jaundice 195.36 11.80 87 782276 59149 109747787
Joint range of motion decreased 194.95 11.80 1503 780860 120329 109686607
Subdural haematoma 194.70 11.80 17 782346 36437 109770499
Accidental exposure to product 194.61 11.80 56 782307 49952 109756984
Stomatitis 194.32 11.80 2835 779528 267407 109539529
Granuloma skin 191.82 11.80 311 782052 10972 109795964
Breast cancer 191.80 11.80 655 781708 37887 109769049
Sinusitis bacterial 191.38 11.80 150 782213 2294 109804642
Hepatosplenic T-cell lymphoma 190.03 11.80 107 782256 900 109806036
Therapy interrupted 189.86 11.80 58 782305 49764 109757172
Lymphoma 189.27 11.80 432 781931 19739 109787197
Generalised tonic-clonic seizure 187.22 11.80 76 782287 54604 109752332
Irritability 187.05 11.80 53 782310 47756 109759180
Adverse event 186.90 11.80 1365 780998 107444 109699492
Angioedema 186.62 11.80 254 782109 98246 109708690
Bursitis 186.27 11.80 1563 780800 128355 109678581
Pulmonary arterial hypertension 185.97 11.80 11 782352 32557 109774379
Pneumonia legionella 185.20 11.80 173 782190 3396 109803540
Blood parathyroid hormone decreased 183.28 11.80 331 782032 12758 109794178
Blood calcium decreased 182.82 11.80 20 782343 35825 109771111
Overdose 180.33 11.80 945 781418 232849 109574087
Tumour lysis syndrome 180.25 11.80 9 782354 30792 109776144
Weight fluctuation 178.38 11.80 447 781916 21698 109785238
Fistula discharge 176.25 11.80 122 782241 1524 109805412
Vomiting 175.95 11.80 5002 777361 905673 108901263
Diarrhoea haemorrhagic 175.42 11.80 360 782003 15279 109791657
Peritoneal tuberculosis 175.35 11.80 85 782278 505 109806431
Panniculitis 175.15 11.80 359 782004 15223 109791713
Transient ischaemic attack 174.73 11.80 119 782244 63863 109743073
Sinus tachycardia 174.67 11.80 49 782314 44444 109762492
Peripheral swelling 174.67 11.80 3912 778451 400122 109406814
Myoclonus 174.59 11.80 16 782347 32982 109773954
Mycobacterium marinum infection 174.07 11.80 92 782271 673 109806263
Extrapyramidal disorder 173.63 11.80 7 782356 28860 109778076
Rectal abscess 172.28 11.80 147 782216 2549 109804387
Sinus bradycardia 171.32 11.80 9 782354 29474 109777462
Malignant melanoma 171.12 11.80 373 781990 16518 109790418
Hypophosphataemia 170.55 11.80 18 782345 33164 109773772
Inappropriate antidiuretic hormone secretion 169.86 11.80 20 782343 33831 109773105
Malaise 169.78 11.80 6074 776289 665745 109141191
Injection site pruritus 169.49 11.80 75 782288 51183 109755753
Device issue 169.39 11.80 22 782341 34513 109772423
Poisoning 168.76 11.80 9 782354 29096 109777840
Neutropenic sepsis 167.91 11.80 13 782350 30733 109776203
Gamma-glutamyltransferase increased 167.47 11.80 114 782249 61195 109745741
Lymphoproliferative disorder 167.24 11.80 230 782133 6988 109799948
Blood cholesterol increased 167.05 11.80 2021 780342 182764 109624172
Haematemesis 166.75 11.80 106 782257 59002 109747934
Knee arthroplasty 166.70 11.80 903 781460 64045 109742891
Withdrawal syndrome 166.61 11.80 15 782348 31365 109775571
Hyperlipidaemia 166.16 11.80 27 782336 35821 109771115
Osteonecrosis of jaw 165.61 11.80 66 782297 47951 109758985
Respiratory depression 165.41 11.80 17 782346 31984 109774952
Therapeutic response decreased 165.40 11.80 1210 781153 95289 109711647
Lip dry 165.33 11.80 1244 781119 98839 109708097
Sinusitis 163.91 11.80 2980 779383 293708 109513228
Septic shock 163.13 11.80 569 781794 156959 109649977
Drug tolerance decreased 162.37 11.80 496 781867 27044 109779892
Labelled drug-drug interaction medication error 161.13 11.80 12 782351 29290 109777646
Injection site swelling 160.78 11.80 121 782242 61669 109745267
Hallucination, auditory 160.14 11.80 6 782357 26391 109780545
Chronic kidney disease 159.96 11.80 182 782181 76109 109730827
Bone pain 158.89 11.80 136 782227 64997 109741939
Dizziness 158.61 11.80 3745 778618 694448 109112488
Hip arthroplasty 158.43 11.80 798 781565 55015 109751921
Enthesopathy 157.75 11.80 302 782061 12176 109794760
Cardiac disorder 157.74 11.80 184 782179 76096 109730840
Injection site bruising 157.32 11.80 83 782280 51180 109755756
Ejection fraction decreased 156.84 11.80 47 782316 40833 109766103
Rheumatoid nodule 156.53 11.80 403 781960 19893 109787043
Cerebral infarction 156.05 11.80 86 782277 51752 109755184
Sciatica 155.74 11.80 1154 781209 91245 109715691
Psychotic disorder 154.08 11.80 84 782279 50853 109756083
Epistaxis 153.87 11.80 444 781919 129928 109677008
Arrhythmia 153.61 11.80 159 782204 69416 109737520
Device dislocation 153.58 11.80 21 782342 31683 109775253
Anal stenosis 153.54 11.80 79 782284 543 109806393
Nausea 153.04 11.80 7166 775197 1228524 108578412
Hepatocellular injury 152.48 11.80 84 782279 50558 109756378
Abnormal behaviour 151.39 11.80 44 782319 38995 109767941
Restlessness 150.50 11.80 107 782256 56152 109750784
Circulatory collapse 150.08 11.80 58 782305 42935 109764001
Loss of consciousness 149.96 11.80 796 781567 195510 109611426
Subarachnoid haemorrhage 147.92 11.80 18 782345 29684 109777252
Hyperbilirubinaemia 146.97 11.80 21 782342 30650 109776286
Polyarthritis 146.73 11.80 377 781986 18586 109788350
Coagulopathy 146.49 11.80 53 782310 40858 109766078
Disability 146.35 11.80 509 781854 29714 109777222
Aspartate aminotransferase increased 146.02 11.80 608 781755 159328 109647608
Torsade de pointes 144.97 11.80 3 782360 22597 109784339
Blood potassium decreased 144.66 11.80 103 782260 54011 109752925
Vein rupture 143.70 11.80 130 782233 2445 109804491
Troponin increased 143.52 11.80 20 782343 29746 109777190
Grip strength decreased 143.00 11.80 1015 781348 79159 109727777
Urinary incontinence 142.83 11.80 83 782280 48504 109758432
Product administration error 142.40 11.80 43 782320 37174 109769762
Ischaemic stroke 141.85 11.80 57 782306 41206 109765730
Blood sodium decreased 141.76 11.80 47 782316 38272 109768664
Paradoxical psoriasis 141.70 11.80 71 782292 458 109806478
Blood potassium increased 141.42 11.80 31 782332 33218 109773718
Renal tubular necrosis 141.15 11.80 23 782340 30452 109776484
Small intestinal resection 140.54 11.80 92 782271 1041 109805895
Colitis ulcerative 140.08 11.80 983 781380 76380 109730556
Anuria 139.66 11.80 8 782355 24333 109782603
Creatinine renal clearance decreased 139.52 11.80 3 782360 21812 109785124
Pneumonitis 139.35 11.80 203 782160 76328 109730608
No adverse event 139.28 11.80 191 782172 73648 109733288
Dysgeusia 138.18 11.80 175 782188 69810 109737126
Mydriasis 138.09 11.80 4 782359 22153 109784783
Tenosynovitis 137.84 11.80 335 782028 15948 109790988
Peripheral venous disease 137.50 11.80 1043 781320 83074 109723862
Miosis 136.89 11.80 4 782359 21979 109784957
Angina pectoris 136.81 11.80 143 782220 62152 109744784
Ileectomy 136.36 11.80 58 782305 240 109806696
Leukocytosis 135.50 11.80 109 782254 53719 109753217
Parkinsonism 134.74 11.80 5 782358 22182 109784754
Pouchitis 134.43 11.80 97 782266 1300 109805636
Haemorrhage intracranial 133.87 11.80 22 782341 28947 109777989
Shock 133.05 11.80 110 782253 53478 109753458
Hypocalcaemia 132.68 11.80 160 782203 65206 109741730
Speech disorder 132.24 11.80 144 782219 61425 109745511
Body temperature decreased 132.07 11.80 565 781798 36370 109770566
Alanine aminotransferase increased 131.72 11.80 761 781602 183012 109623924
Coeliac disease 131.52 11.80 630 781733 42557 109764379
Status epilepticus 131.16 11.80 31 782332 31540 109775396
Lymphopenia 130.90 11.80 60 782303 40110 109766826
Osteoarthritis 129.69 11.80 1912 780451 180711 109626225
Hemiparesis 129.05 11.80 75 782288 43828 109763108
Loss of therapeutic response 128.96 11.80 121 782242 2389 109804547
Depressed mood 128.65 11.80 144 782219 60665 109746271
Pericardial effusion 127.17 11.80 130 782233 57087 109749849
Faecal calprotectin abnormal 126.77 11.80 58 782305 296 109806640
Activated partial thromboplastin time prolonged 126.38 11.80 8 782355 22360 109784576
Cytopenia 126.24 11.80 29 782334 30087 109776849
Acute hepatic failure 125.98 11.80 50 782313 36418 109770518
Ileocaecal resection 125.83 11.80 68 782295 523 109806413
Neoplasm malignant 125.80 11.80 559 781804 36584 109770352
Nephrolithiasis 125.01 11.80 850 781513 65362 109741574
Apparent death 124.97 11.80 127 782236 2775 109804161
Electrolyte imbalance 124.30 11.80 53 782310 36975 109769961
Right ventricular failure 123.83 11.80 18 782345 25936 109781000
Hepatic cytolysis 123.60 11.80 124 782239 54929 109752007
Salmonellosis 123.26 11.80 112 782251 2119 109804817
Deep vein thrombosis 123.26 11.80 539 781824 139348 109667588
Blood lactate dehydrogenase increased 123.02 11.80 81 782282 44253 109762683
Dystonia 122.87 11.80 18 782345 25787 109781149
Aplastic anaemia 122.87 11.80 14 782349 24294 109782642
Drug level abnormal 122.85 11.80 66 782297 501 109806435
Dysuria 122.71 11.80 147 782216 60084 109746852
Delusion 121.80 11.80 13 782350 23742 109783194
Transplant rejection 121.79 11.80 417 781946 24150 109782786
Hepatic encephalopathy 120.88 11.80 26 782337 28230 109778706
Brain oedema 120.68 11.80 35 782328 31063 109775873
Diabetes mellitus inadequate control 120.26 11.80 31 782332 29744 109777192
Mammoplasty 120.26 11.80 60 782303 383 109806553
Nephropathy toxic 120.21 11.80 24 782339 27454 109779482
Left ventricular dysfunction 120.09 11.80 13 782350 23480 109783456
Schizophrenia 119.84 11.80 9 782354 21817 109785119
Tuberculous pleurisy 119.81 11.80 70 782293 636 109806300
Decreased appetite 119.14 11.80 2513 779850 473333 109333603
Therapy cessation 119.09 11.80 86 782277 44771 109762165
IgA nephropathy 119.03 11.80 129 782234 3044 109803892
Haematocrit decreased 118.80 11.80 177 782186 65940 109740996
Inflammatory bowel disease 118.38 11.80 196 782167 7038 109799898
Meningitis listeria 117.87 11.80 87 782276 1210 109805726
Blood uric acid increased 117.86 11.80 9 782354 21520 109785416
Tricuspid valve incompetence 117.59 11.80 15 782348 23858 109783078
Glomerular filtration rate decreased 117.24 11.80 30 782333 28926 109778010
Pancreatitis acute 116.64 11.80 153 782210 60121 109746815
Hidradenitis 115.44 11.80 162 782201 5018 109801918
Therapy non-responder 114.86 11.80 1655 780708 155652 109651284
End stage renal disease 114.72 11.80 10 782353 21463 109785473
Henoch-Schonlein purpura 113.92 11.80 135 782228 3522 109803414
Hypernatraemia 111.95 11.80 3 782360 17830 109789106
Nail disorder 111.92 11.80 748 781615 57187 109749749
Thrombotic microangiopathy 110.95 11.80 34 782329 29115 109777821
Cardiomegaly 110.83 11.80 34 782329 29096 109777840
Onychomadesis 110.58 11.80 625 781738 45038 109761898
Emotional distress 110.18 11.80 93 782270 44754 109762182
Colectomy total 110.14 11.80 59 782304 445 109806491
Second primary malignancy 109.97 11.80 4 782359 18064 109788872
General physical health deterioration 109.91 11.80 3856 778507 421439 109385497
Arteriosclerosis coronary artery 109.75 11.80 22 782341 25096 109781840
Ataxia 109.52 11.80 38 782325 30070 109776866
Accidental overdose 109.38 11.80 123 782240 51711 109755225
Atrial flutter 108.66 11.80 20 782343 24242 109782694
Rash 107.51 11.80 6956 775407 814008 108992928
Affect lability 107.32 11.80 6 782357 18631 109788305
Hypothermia 106.97 11.80 27 782336 26275 109780661
Shock haemorrhagic 106.97 11.80 30 782333 27217 109779719
Injury 106.59 11.80 1805 780558 175460 109631476
Ankylosing spondylitis 106.27 11.80 296 782067 15316 109791620
Pseudopolyp 105.61 11.80 63 782300 597 109806339
Cardiac failure acute 105.40 11.80 21 782342 24057 109782879
Pustular psoriasis 104.77 11.80 270 782093 13335 109793601
Acidosis 104.36 11.80 17 782346 22514 109784422
Proctocolectomy 103.82 11.80 45 782318 197 109806739
Demyelination 103.35 11.80 215 782148 9214 109797722
Cholangitis sclerosing 103.04 11.80 127 782236 3455 109803481
Wound infection 102.95 11.80 1090 781273 95375 109711561
Obesity 102.52 11.80 1240 781123 112111 109694825
Polyneuropathy 102.48 11.80 49 782314 31963 109774973
Blood pressure diastolic abnormal 102.14 11.80 28 782335 25787 109781149
Blood pressure systolic abnormal 102.05 11.80 25 782338 24825 109782111
Haematotoxicity 102.03 11.80 14 782349 21068 109785868
Needle issue 101.94 11.80 6 782357 17834 109789102
Hyperphosphataemia 101.93 11.80 3 782360 16378 109790558
Blood phosphorus increased 101.65 11.80 3 782360 16337 109790599
Urine output decreased 101.59 11.80 11 782352 19865 109787071
Listeriosis 101.38 11.80 112 782251 2702 109804234
Treatment noncompliance 101.22 11.80 229 782134 72761 109734175
Device malfunction 100.60 11.80 28 782335 25530 109781406
Coordination abnormal 100.50 11.80 27 782336 25201 109781735
Muscle spasticity 100.49 11.80 65 782298 35850 109771086
Hodgkin's disease 100.29 11.80 66 782297 754 109806182
Cutaneous leishmaniasis 99.91 11.80 51 782312 344 109806592
Onychomycosis 99.06 11.80 536 781827 37995 109768941
Intestinal operation 99.00 11.80 59 782304 558 109806378
Aspiration 98.88 11.80 46 782317 30487 109776449
Respiratory distress 98.87 11.80 212 782151 68662 109738274
Oliguria 98.83 11.80 9 782354 18648 109788288
Respiratory tract infection 98.26 11.80 226 782137 71391 109735545
Hyperthyroidism 98.03 11.80 42 782321 29219 109777717
Neuralgia 98.03 11.80 119 782244 48359 109758577
Mania 97.88 11.80 15 782348 20781 109786155
Joint destruction 97.87 11.80 230 782133 10713 109796223
Device difficult to use 97.17 11.80 10 782353 18795 109788141
Serum sickness 97.01 11.80 137 782226 4269 109802667
Paranoia 96.92 11.80 20 782343 22354 109784582
Hypertension 96.83 11.80 4474 777889 505610 109301326
Liver injury 96.12 11.80 1547 780816 148866 109658070
Metastases to bone 95.96 11.80 51 782312 31321 109775615
Anhedonia 95.37 11.80 3 782360 15425 109791511
Human antichimeric antibody positive 95.36 11.80 87 782276 1655 109805281
Rectal haemorrhage 94.85 11.80 1279 781084 118554 109688382
Infectious mononucleosis 94.52 11.80 97 782266 2145 109804791
Visual acuity reduced 94.51 11.80 55 782308 32118 109774818
Night sweats 94.41 11.80 1401 780962 132582 109674354
Productive cough 94.39 11.80 451 781912 113854 109693082
Myelodysplastic syndrome 94.23 11.80 76 782287 37408 109769528
Breast cancer stage III 94.03 11.80 914 781449 78203 109728733
Product dose omission in error 93.97 11.80 25 782338 23487 109783449
Hepatotoxicity 93.66 11.80 192 782171 63208 109743728
Injection site rash 93.41 11.80 25 782338 23394 109783542
Muscle rigidity 93.34 11.80 27 782336 24004 109782932
Throat tightness 93.06 11.80 476 781887 33013 109773923
Gait inability 92.98 11.80 1418 780945 134958 109671978
Acute myeloid leukaemia 92.44 11.80 80 782283 38030 109768906
Diplopia 92.19 11.80 96 782267 41798 109765138
Sleep apnoea syndrome 92.07 11.80 90 782273 40357 109766579
Red blood cell count decreased 91.28 11.80 207 782156 65716 109741220
Deep vein thrombosis postoperative 91.25 11.80 725 781638 58566 109748370
Antinuclear antibody positive 91.22 11.80 201 782162 8967 109797969
Anorectal disorder 91.20 11.80 105 782258 2654 109804282
Immune effector cell-associated neurotoxicity syndrome 90.93 11.80 3 782360 14779 109792157
Hepatic function abnormal 90.78 11.80 325 782038 88970 109717966
Proteinuria 89.99 11.80 90 782273 39928 109767008
Pulmonary fibrosis 89.98 11.80 1111 781252 100931 109706005
Device leakage 89.90 11.80 6 782357 16042 109790894
Pollakiuria 89.88 11.80 108 782255 44087 109762849
Chromaturia 89.41 11.80 48 782315 29312 109777624
Myalgia 89.40 11.80 1074 781289 221307 109585629
Cough 89.27 11.80 2534 779829 459107 109347829
Eosinophil count increased 88.82 11.80 20 782343 21038 109785898
Hypovolaemia 88.63 11.80 22 782341 21652 109785284
Sudden death 88.37 11.80 31 782332 24364 109782572
Liver disorder 88.30 11.80 1456 780907 140787 109666149
Dialysis 88.24 11.80 16 782347 19603 109787333
Psychomotor hyperactivity 88.10 11.80 18 782345 20259 109786677
Confusional state 88.02 11.80 2583 779780 466097 109340839
Product prescribing error 87.84 11.80 142 782221 51189 109755747
Musculoskeletal deformity 87.84 11.80 79 782284 1474 109805462
Renal injury 86.94 11.80 14 782349 18699 109788237
Mental impairment 86.90 11.80 26 782337 22613 109784323
Muscle twitching 86.77 11.80 52 782311 29883 109777053
Dry eye 86.70 11.80 164 782199 55629 109751307
Hysterectomy 86.58 11.80 183 782180 7931 109799005
Rectal stenosis 86.53 11.80 48 782315 391 109806545
Pulseless electrical activity 86.35 11.80 9 782354 16748 109790188
Oropharyngeal pain 85.94 11.80 1390 780973 133886 109673050
Blood glucose decreased 85.79 11.80 51 782312 29437 109777499
Drug dose omission by device 85.72 11.80 4 782359 14512 109792424
Rheumatoid factor negative 85.36 11.80 72 782291 1228 109805708
Mitral valve incompetence 84.50 11.80 67 782296 33262 109773674
Toxic encephalopathy 84.32 11.80 6 782357 15208 109791728
B-cell lymphoma 84.19 11.80 168 782195 6986 109799950
COVID-19 pneumonia 84.14 11.80 83 782280 37060 109769876
Femur fracture 83.89 11.80 115 782248 44354 109762582
Anal cancer 83.72 11.80 59 782304 760 109806176
Rales 83.70 11.80 35 782328 24704 109782232
Dislocation of vertebra 83.56 11.80 563 781800 43158 109763778
Atelectasis 83.20 11.80 82 782281 36630 109770306
Neutrophil count increased 82.53 11.80 74 782289 34578 109772358
Infected fistula 82.43 11.80 49 782314 461 109806475
Intestinal fistula 82.32 11.80 80 782283 1653 109805283
Toxic skin eruption 82.31 11.80 46 782317 27469 109779467
Myasthenia gravis 82.04 11.80 25 782338 21486 109785450
Tachycardia 81.70 11.80 1120 781243 225525 109581411
Thirst 81.40 11.80 26 782337 21681 109785255
Febrile bone marrow aplasia 81.29 11.80 13 782350 17452 109789484
Stoma creation 81.08 11.80 36 782327 169 109806767
Haemodialysis 80.67 11.80 14 782349 17705 109789231
Suspected COVID-19 80.47 11.80 111 782252 3382 109803554
Blood pressure diastolic increased 80.27 11.80 304 782059 18503 109788433
Autoimmune disorder 80.04 11.80 761 781602 64722 109742214
Transfusion 80.01 11.80 40 782323 25432 109781504
Hiatus hernia 79.95 11.80 48 782315 27558 109779378
Injection site mass 79.83 11.80 37 782326 24576 109782360
Dermatitis psoriasiform 79.78 11.80 113 782250 3531 109803405
Proctectomy 79.61 11.80 42 782321 306 109806630
Enterostomy 79.43 11.80 36 782327 179 109806757
Myocardial ischaemia 79.26 11.80 45 782318 26639 109780297
Squamous cell carcinoma 79.26 11.80 299 782064 18164 109788772
Atrioventricular block complete 79.04 11.80 22 782341 20060 109786876
Glycosylated haemoglobin increased 78.97 11.80 34 782329 23585 109783351
Interstitial lung disease 78.81 11.80 619 781744 138715 109668221
Body height below normal 78.66 11.80 85 782278 1999 109804937
Infective pulmonary exacerbation of cystic fibrosis 78.58 11.80 7 782356 14764 109792172
Blood calcium increased 78.41 11.80 16 782347 18024 109788912
Blood loss anaemia 78.32 11.80 16 782347 18009 109788927
Tachypnoea 78.29 11.80 98 782265 39297 109767639
Tonsillitis 78.28 11.80 177 782186 8036 109798900
Oxygen saturation decreased 78.20 11.80 721 781642 156261 109650675
Non-Hodgkin's lymphoma 78.18 11.80 72 782291 1387 109805549
Hypoacusis 78.16 11.80 80 782283 35111 109771825
Cardiac failure chronic 77.85 11.80 5 782358 13806 109793130
Prothrombin time prolonged 77.80 11.80 14 782349 17247 109789689
Asthma 77.77 11.80 1273 781090 249018 109557918
Acute generalised exanthematous pustulosis 77.67 11.80 28 782335 21636 109785300
Metastases to central nervous system 77.65 11.80 32 782331 22785 109784151
Road traffic accident 77.62 11.80 1128 781235 106270 109700666
Ear infection bacterial 77.28 11.80 38 782325 234 109806702
Gout 76.90 11.80 87 782276 36479 109770457
Polyuria 76.54 11.80 16 782347 17722 109789214
Haemodynamic instability 76.44 11.80 33 782330 22855 109784081
Dysphonia 76.09 11.80 278 782085 75651 109731285
Blindness 75.93 11.80 87 782276 36272 109770664
Wisdom teeth removal 75.85 11.80 55 782308 743 109806193
Cardiomyopathy 75.84 11.80 75 782288 33450 109773486
Musculoskeletal pain 75.80 11.80 1762 780601 181261 109625675
Red blood cell sedimentation rate 75.75 11.80 134 782229 5080 109801856
Extrapulmonary tuberculosis 75.62 11.80 48 782315 513 109806423
Renal disorder 75.53 11.80 147 782216 49332 109757604
Blood lactic acid increased 75.41 11.80 11 782352 15810 109791126
Atrioventricular block 75.40 11.80 14 782349 16863 109790073
Skin necrosis 75.31 11.80 327 782036 21185 109785751
Respiratory acidosis 75.07 11.80 6 782357 13820 109793116
Ventricular extrasystoles 75.05 11.80 33 782330 22608 109784328
Delirium 74.91 11.80 603 781760 134422 109672514
Unevaluable event 74.88 11.80 195 782168 59032 109747904
Cholelithiasis 74.81 11.80 216 782147 63206 109743730
Salivary hypersecretion 74.59 11.80 16 782347 17405 109789531
Feeling abnormal 74.45 11.80 868 781495 179843 109627093
Hyperammonaemia 74.45 11.80 6 782357 13726 109793210
Sinus disorder 74.29 11.80 73 782290 32655 109774281
Peripheral sensory neuropathy 74.17 11.80 14 782349 16666 109790270
Blood pressure diastolic decreased 74.00 11.80 471 781892 35414 109771522
Dementia 73.81 11.80 69 782294 31604 109775332
Acute respiratory distress syndrome 73.69 11.80 167 782196 53031 109753905
Hepatitis cholestatic 73.46 11.80 17 782346 17549 109789387
Hypercholesterolaemia 73.32 11.80 973 781390 89864 109717072
Dermatitis atopic 73.15 11.80 45 782318 25496 109781440
Abscess intestinal 73.14 11.80 103 782260 3201 109803735
Gastric ulcer 73.13 11.80 105 782258 39722 109767214
Erythema 72.88 11.80 2633 779730 288814 109518122
Pharyngitis streptococcal 72.62 11.80 233 782130 13044 109793892
Mixed liver injury 72.41 11.80 3 782360 12076 109794860
Hyperuricaemia 71.89 11.80 9 782354 14522 109792414
Drug eruption 71.86 11.80 636 781727 53023 109753913
Blepharospasm 71.85 11.80 647 781716 54204 109752732
Bowel movement irregularity 71.81 11.80 164 782199 7496 109799440
Haemolytic anaemia 71.74 11.80 29 782334 20891 109786045
Vascular access complication 71.71 11.80 89 782274 2439 109804497
Diastolic dysfunction 71.40 11.80 4 782359 12400 109794536
Personality disorder 71.32 11.80 5 782358 12832 109794104
Muscular weakness 71.29 11.80 1282 781081 247186 109559750
Rectal tenesmus 71.28 11.80 84 782279 2178 109804758
Legionella infection 71.26 11.80 57 782306 899 109806037
Hepatitis acute 71.22 11.80 22 782341 18744 109788192
Exposure via skin contact 70.57 11.80 6 782357 13141 109793795
Hypogammaglobulinaemia 70.21 11.80 27 782336 20049 109786887
Antibody test positive 70.16 11.80 98 782265 3022 109803914
Tinnitus 70.09 11.80 208 782155 60332 109746604
Acute pulmonary oedema 69.99 11.80 17 782346 16979 109789957
Immunosuppressant drug level increased 69.99 11.80 3 782360 11721 109795215
Adjustment disorder with depressed mood 69.95 11.80 541 781822 43342 109763594
Head injury 69.92 11.80 123 782240 42894 109764042
Decubitus ulcer 69.90 11.80 21 782342 18215 109788721
Prescribed overdose 69.81 11.80 936 781427 86645 109720291
Graft versus host disease 69.68 11.80 23 782340 18783 109788153
Live birth 69.45 11.80 775 781588 68709 109738227
Device breakage 69.42 11.80 8 782355 13761 109793175
DNA antibody positive 69.18 11.80 38 782325 303 109806633
Chest discomfort 69.04 11.80 1664 780699 172184 109634752
Pulmonary alveolar haemorrhage 68.99 11.80 28 782335 20122 109786814
Drug effective for unapproved indication 68.94 11.80 239 782124 13928 109793008
Contraindication to vaccination 68.92 11.80 33 782330 190 109806746
Small intestinal stenosis 68.82 11.80 64 782299 1249 109805687
Mesenteritis 68.68 11.80 39 782324 334 109806602
Surgical failure 68.16 11.80 55 782308 879 109806057
Disseminated intravascular coagulation 68.06 11.80 117 782246 41169 109765767
Thrombosis 68.04 11.80 469 781894 108193 109698743
Injection site haemorrhage 67.93 11.80 80 782283 32948 109773988
Feeling hot 67.87 11.80 962 781401 90144 109716792
Arteriosclerosis 67.71 11.80 46 782317 24721 109782215
Fear 67.63 11.80 40 782323 23153 109783783
Electrocardiogram abnormal 67.39 11.80 24 782339 18685 109788251
Blood triglycerides increased 67.35 11.80 43 782320 23883 109783053
Clear cell renal cell carcinoma 67.16 11.80 90 782273 2666 109804270
Haemorrhagic stroke 67.11 11.80 9 782354 13780 109793156
X-ray abnormal 67.05 11.80 481 781882 37636 109769300
Pathogen resistance 66.56 11.80 21 782342 17651 109789285
Premature delivery 66.49 11.80 71 782292 30561 109776375
Anxiety 66.45 11.80 1895 780468 343183 109463753
Supraventricular tachycardia 65.91 11.80 46 782317 24376 109782560
Abdominal abscess 65.84 11.80 173 782190 8646 109798290
Nasal polyps 65.73 11.80 8 782355 13192 109793744
Ear infection 65.60 11.80 706 781657 62026 109744910
Sports injury 65.53 11.80 31 782332 173 109806763
Metabolic encephalopathy 65.46 11.80 3 782360 11057 109795879
Hemiplegia 65.44 11.80 40 782323 22742 109784194
Hip fracture 65.21 11.80 92 782271 35059 109771877
Infusion site reaction 65.16 11.80 273 782090 17409 109789527
Device occlusion 64.90 11.80 14 782349 15171 109791765
Erectile dysfunction 64.82 11.80 25 782338 18531 109788405
Atlantoaxial instability 64.68 11.80 35 782328 270 109806666
Thinking abnormal 64.63 11.80 14 782349 15126 109791810
Contrast media allergy 64.62 11.80 99 782264 3324 109803612
Rhinitis allergic 64.53 11.80 23 782340 17899 109789037
Posterior reversible encephalopathy syndrome 64.45 11.80 87 782276 33774 109773162
Tuberculosis gastrointestinal 64.42 11.80 45 782318 571 109806365
Concomitant disease aggravated 64.27 11.80 18 782345 16346 109790590
Swelling face 64.16 11.80 386 781977 91935 109715001
Fluid retention 64.13 11.80 397 781966 93910 109713026
Immune thrombocytopenia 63.91 11.80 40 782323 22454 109784482
Adjustment disorder 63.66 11.80 3 782360 10792 109796144
Colitis ischaemic 63.54 11.80 23 782340 17727 109789209
Apathy 63.53 11.80 18 782345 16221 109790715
Pyrexia 63.22 11.80 5483 776880 892782 108914154
Streptococcal infection 63.14 11.80 195 782168 10695 109796241
Abnormal dreams 63.02 11.80 8 782355 12772 109794164
Deformity 62.73 11.80 186 782177 9974 109796962
Gangrene 62.30 11.80 19 782344 16322 109790614
Transaminases increased 62.27 11.80 234 782129 63156 109743780
Duodenal ulcer 62.27 11.80 30 782333 19484 109787452
Back injury 61.52 11.80 558 781805 46841 109760095
Cervical dysplasia 61.52 11.80 86 782277 2654 109804282
Lower limb fracture 61.18 11.80 808 781555 74540 109732396
Proctalgia 60.85 11.80 219 782144 13003 109793933
Skin haemorrhage 60.36 11.80 52 782311 24775 109782161
Granulocytopenia 60.24 11.80 9 782354 12706 109794230
Hypercapnia 60.15 11.80 5 782358 11154 109795782
Migraine 59.93 11.80 1615 780748 170037 109636899
Injection site warmth 59.89 11.80 24 782339 17381 109789555
Pericarditis tuberculous 59.82 11.80 25 782338 98 109806838
Drain placement 59.68 11.80 30 782333 195 109806741
Gastritis 59.67 11.80 188 782175 53511 109753425
Cytomegalovirus colitis 59.48 11.80 145 782218 6916 109800020
Motor dysfunction 59.48 11.80 51 782312 24355 109782581
Jaundice cholestatic 59.40 11.80 15 782348 14593 109792343
Nocturia 59.17 11.80 23 782340 16967 109789969
Arthrodesis 59.08 11.80 84 782279 2634 109804302
Hiccups 58.96 11.80 10 782353 12859 109794077
Nightmare 58.85 11.80 116 782247 38747 109768189
Substance abuse 58.64 11.80 9 782354 12454 109794482
Subcutaneous abscess 57.94 11.80 171 782192 9146 109797790
Physical disability 57.81 11.80 118 782245 4988 109801948
Pulmonary haemorrhage 57.77 11.80 22 782341 16434 109790502
Bradykinesia 57.70 11.80 5 782358 10783 109796153
Stress cardiomyopathy 57.40 11.80 20 782343 15786 109791150
Product label confusion 57.31 11.80 314 782049 22363 109784573
Acute graft versus host disease 56.87 11.80 11 782352 12870 109794066
Tuberculin test positive 56.85 11.80 97 782266 3571 109803365
Ulcer 56.69 11.80 509 781854 42607 109764329
Hypomania 56.66 11.80 4 782359 10206 109796730
Intestinal sepsis 56.64 11.80 51 782312 953 109805983
Oesophagitis 56.47 11.80 72 782291 28643 109778293
Lipase increased 56.17 11.80 31 782332 18641 109788295
Respiratory tract congestion 56.02 11.80 82 782281 30775 109776161
Respiratory symptom 55.86 11.80 18 782345 14927 109792009
Joint stiffness 55.82 11.80 724 781639 66519 109740417
Lymphoedema 55.77 11.80 18 782345 14911 109792025
Aplasia pure red cell 55.41 11.80 3 782360 9575 109797361
Bundle branch block right 55.33 11.80 10 782353 12281 109794655
Petechiae 55.28 11.80 50 782313 23267 109783669
Complication associated with device 55.25 11.80 37 782326 20036 109786900
Left ventricular hypertrophy 55.02 11.80 13 782350 13231 109793705
Mineral metabolism disorder 54.91 11.80 35 782328 377 109806559
Nephropathy 54.43 11.80 14 782349 13453 109793483
Bronchitis 54.09 11.80 783 781580 156249 109650687
Sleep disorder due to a general medical condition 54.08 11.80 188 782175 51924 109755012
Alanine aminotransferase abnormal 53.99 11.80 167 782196 9167 109797769
Aortic stenosis 53.90 11.80 13 782350 13046 109793890
Hypotonia 53.71 11.80 22 782341 15723 109791213
Stoma obstruction 53.68 11.80 31 782332 275 109806661
Skin discolouration 53.59 11.80 173 782190 48873 109758063
Hypoalbuminaemia 53.58 11.80 76 782287 28898 109778038
Antinuclear antibody increased 53.46 11.80 53 782310 1123 109805813
Pemphigoid 53.34 11.80 37 782326 19670 109787266
Blood thyroid stimulating hormone increased 53.28 11.80 11 782352 12290 109794646
White coat hypertension 53.26 11.80 56 782307 1275 109805661
Nystagmus 53.03 11.80 9 782354 11568 109795368
Ventricular hypokinesia 52.98 11.80 8 782355 11206 109795730
Myopathy 52.91 11.80 59 782304 24901 109782035
Mood altered 52.91 11.80 44 782319 21331 109785605
Femoral neck fracture 52.88 11.80 12 782351 12555 109794381
Immunodeficiency 52.87 11.80 462 781901 38376 109768560
Coronary artery stenosis 52.45 11.80 16 782347 13742 109793194
Protein urine present 52.45 11.80 9 782354 11475 109795461
Spinal instability 52.32 11.80 36 782327 445 109806491
Enterocutaneous fistula 52.29 11.80 73 782290 2250 109804686
Eosinophilic granulomatosis with polyangiitis 51.94 11.80 7 782356 10679 109796257
Hydronephrosis 51.82 11.80 42 782321 20623 109786313
Vasectomy 51.78 11.80 15 782348 10 109806926
Vascular device infection 51.76 11.80 26 782337 16486 109790450
Dissociation 51.46 11.80 5 782358 9837 109797099
Post transplant lymphoproliferative disorder 51.37 11.80 23 782340 15590 109791346
Systemic infection 51.31 11.80 5 782358 9814 109797122
Steroid dependence 51.30 11.80 154 782209 8315 109798621
Arterial occlusive disease 51.24 11.80 22 782341 15286 109791650
Injection site urticaria 51.18 11.80 29 782334 17186 109789750
Bronchitis bacterial 51.06 11.80 64 782299 1772 109805164
Blood iron abnormal 51.00 11.80 58 782305 1446 109805490
White blood cell count increased 50.76 11.80 439 781924 96403 109710533
Brain natriuretic peptide increased 50.72 11.80 9 782354 11200 109795736
Ventricular arrhythmia 50.51 11.80 6 782357 10081 109796855
Lip swelling 50.44 11.80 186 782177 50481 109756455
Carotid artery thrombosis 50.12 11.80 5 782358 9633 109797303
Lower gastrointestinal haemorrhage 49.65 11.80 35 782328 18451 109788485
Partial seizures 49.46 11.80 10 782353 11339 109795597
Skin burning sensation 49.17 11.80 49 782314 21776 109785160
Ageusia 49.17 11.80 40 782323 19605 109787331
Insurance issue 49.17 11.80 8 782355 10604 109796332
Drug tolerance 49.10 11.80 240 782123 16345 109790591
Wheelchair user 48.83 11.80 144 782219 7698 109799238
Bronchitis chronic 48.81 11.80 108 782255 4832 109802104
Faeces soft 48.50 11.80 182 782181 11028 109795908
Blood creatine increased 48.48 11.80 11 782352 11510 109795426
Metastases to lung 48.36 11.80 55 782308 23008 109783928
Metastases to liver 48.27 11.80 112 782251 35274 109771662
Azotaemia 48.10 11.80 7 782356 10078 109796858
Adverse drug reaction 48.02 11.80 1030 781333 104529 109702407
Sneezing 47.97 11.80 96 782267 31888 109775048
Erythema multiforme 47.95 11.80 47 782316 21050 109785886
Blood test abnormal 47.91 11.80 80 782283 28474 109778462
Maternal exposure timing unspecified 47.87 11.80 283 782080 20730 109786206
Bradyphrenia 47.77 11.80 12 782351 11716 109795220
Ankle deformity 47.72 11.80 40 782323 676 109806260
Behaviour disorder 47.66 11.80 6 782357 9641 109797295
Bronchopulmonary aspergillosis allergic 47.64 11.80 3 782360 8423 109798513
Drug level increased 47.62 11.80 175 782188 47544 109759392
Gastrointestinal scarring 47.54 11.80 34 782329 449 109806487
Plasmablastic lymphoma 47.39 11.80 42 782321 768 109806168
Low density lipoprotein increased 47.32 11.80 9 782354 10657 109796279
Candida infection 47.30 11.80 177 782186 47832 109759104
C-reactive protein 47.28 11.80 372 781991 29959 109776977
T-cell lymphoma 47.16 11.80 57 782306 1519 109805417
Swollen tongue 47.05 11.80 243 782120 60119 109746817
Methaemoglobinaemia 47.05 11.80 5 782358 9163 109797773
Angina unstable 46.99 11.80 29 782334 16403 109790533
Joint ankylosis 46.83 11.80 72 782291 2425 109804511
Temperature intolerance 46.77 11.80 20 782343 13930 109793006
Clonus 46.72 11.80 4 782359 8712 109798224
Hyperlactacidaemia 46.70 11.80 3 782360 8283 109798653
Pulmonary function test decreased 46.62 11.80 4 782359 8696 109798240
Device use error 46.53 11.80 5 782358 9084 109797852
Ammonia increased 46.46 11.80 3 782360 8247 109798689
Product storage error 46.45 11.80 51 782312 21677 109785259
Double stranded DNA antibody 46.44 11.80 17 782346 42 109806894
Cholecystitis acute 46.33 11.80 27 782336 15755 109791181
Device related infection 46.31 11.80 135 782228 39384 109767552
Impaired work ability 46.24 11.80 333 782030 26086 109780850
Oxygen saturation abnormal 45.97 11.80 114 782249 5497 109801439
Ileus paralytic 45.93 11.80 13 782350 11724 109795212
Pregnancy 45.87 11.80 558 781805 50509 109756427
Osteonecrosis 45.86 11.80 107 782256 33634 109773302
Intestinal ischaemia 45.65 11.80 29 782334 16150 109790786
Lung opacity 45.42 11.80 13 782350 11639 109795297
Cutaneous T-cell lymphoma 45.38 11.80 84 782279 3300 109803636
Vein collapse 45.34 11.80 51 782312 1256 109805680
Personality change 45.31 11.80 11 782352 10991 109795945
Opportunistic infection 45.10 11.80 86 782277 3457 109803479
Hypertensive crisis 45 11.80 64 782299 24308 109782628
Hypoxic-ischaemic encephalopathy 44.95 11.80 5 782358 8842 109798094
Dyslipidaemia 44.52 11.80 29 782334 15936 109791000
Blood chloride decreased 44.24 11.80 6 782357 9109 109797827
Retinitis 44.24 11.80 385 781978 31942 109774994
Injection site discolouration 44.16 11.80 6 782357 9097 109797839
Anastomotic ulcer 44.01 11.80 46 782317 1040 109805896
Bundle branch block left 43.98 11.80 18 782345 12870 109794066
Pulmonary congestion 43.88 11.80 96 782267 30870 109776066
Gastric ulcer haemorrhage 43.77 11.80 9 782354 10085 109796851
Tubulointerstitial nephritis 43.75 11.80 216 782147 54068 109752868
Anticipatory anxiety 43.55 11.80 49 782314 1207 109805729
Orthopnoea 43.51 11.80 12 782351 11009 109795927
Psychomotor retardation 43.39 11.80 3 782360 7789 109799147
Foot deformity 43.23 11.80 529 781834 47951 109758985
Purpura 43.12 11.80 66 782297 24322 109782614
Amyotrophic lateral sclerosis 43.08 11.80 63 782300 2028 109804908
Anorectal discomfort 42.81 11.80 92 782271 4034 109802902
Joint arthroplasty 42.75 11.80 84 782279 3453 109803483
Perirectal abscess 42.72 11.80 65 782298 2169 109804767
Pharyngeal paraesthesia 42.72 11.80 92 782271 4040 109802896
Exercise tolerance decreased 42.58 11.80 16 782347 12051 109794885
Brain injury 42.57 11.80 21 782342 13455 109793481
Haemorrhage 42.20 11.80 517 781846 106175 109700761
Benign prostatic hyperplasia 42.17 11.80 40 782323 18194 109788742
Gynaecomastia 42.12 11.80 8 782355 9482 109797454
Intestinal anastomosis 42.02 11.80 42 782321 899 109806037
Faeces discoloured 41.98 11.80 113 782250 33835 109773101
Amylase increased 41.89 11.80 18 782345 12501 109794435
Embolic stroke 41.86 11.80 6 782357 8737 109798199
Progressive multifocal leukoencephalopathy 41.80 11.80 70 782293 24886 109782050
Arthritis enteropathic 41.64 11.80 30 782333 401 109806535
Gastric haemorrhage 41.61 11.80 31 782332 15884 109791052
Hypertransaminasaemia 41.59 11.80 67 782296 24188 109782748
Burning sensation 41.24 11.80 303 782060 68909 109738027
SAPHO syndrome 41.24 11.80 34 782329 561 109806375
Generalised oedema 41.22 11.80 98 782265 30606 109776330
Aortic arteriosclerosis 41.19 11.80 13 782350 10925 109796011
Stupor 41.18 11.80 5 782358 8260 109798676
Complications of transplanted kidney 41.06 11.80 3 782360 7439 109799497
Blood glucose abnormal 40.99 11.80 20 782343 12896 109794040
International normalised ratio decreased 40.99 11.80 5 782358 8231 109798705
Sensory loss 40.97 11.80 55 782308 21402 109785534
Superficial spreading melanoma stage unspecified 40.91 11.80 28 782335 343 109806593
Drug specific antibody absent 40.81 11.80 24 782339 221 109806715
Neuritis 40.77 11.80 3 782360 7396 109799540
Anal fistula infection 40.75 11.80 19 782344 102 109806834
Serum ferritin decreased 40.65 11.80 75 782288 2939 109803997
Peritonitis bacterial 40.61 11.80 12 782351 10521 109796415
BK virus infection 40.54 11.80 21 782342 13085 109793851
Pain in jaw 40.47 11.80 205 782158 50972 109755964
Pregnancy of partner 40.33 11.80 26 782337 286 109806650
Cytology abnormal 40.27 11.80 27 782336 319 109806617
Tongue disorder 40.27 11.80 204 782159 14094 109792842
Cholecystitis chronic 40.12 11.80 9 782354 9491 109797445
Upper-airway cough syndrome 40.04 11.80 32 782331 15825 109791111
Intestinal ulcer 40.04 11.80 66 782297 2361 109804575
Eye pruritus 39.85 11.80 110 782253 32665 109774271
Pulse absent 39.80 11.80 15 782348 11277 109795659
Impaired quality of life 39.79 11.80 355 782008 29662 109777274
Spondyloarthropathy 39.78 11.80 53 782310 1561 109805375
Multiple-drug resistance 39.77 11.80 22 782341 13213 109793723
Endometriosis 39.75 11.80 92 782271 4242 109802694
Iritis 39.69 11.80 96 782267 4556 109802380
Ankle operation 39.64 11.80 49 782314 1337 109805599
Therapy partial responder 39.61 11.80 132 782231 36929 109770007
Epstein Barr virus positive mucocutaneous ulcer 39.57 11.80 45 782318 1122 109805814
Myocarditis 39.51 11.80 97 782266 29958 109776978
Latent tuberculosis 39.35 11.80 87 782276 3890 109803046
Chronic recurrent multifocal osteomyelitis 39.30 11.80 17 782346 74 109806862
Varicella 39.27 11.80 84 782279 3671 109803265
Cytomegalovirus infection reactivation 39.23 11.80 43 782320 18290 109788646
Apnoea 39.10 11.80 24 782339 13615 109793321
Visual impairment 39.04 11.80 692 781671 133736 109673200
Listeria sepsis 38.99 11.80 38 782325 788 109806148
Cerebral haematoma 38.95 11.80 10 782353 9622 109797314
Pseudomonas infection 38.93 11.80 87 782276 27766 109779170
Long QT syndrome 38.90 11.80 3 782360 7115 109799821
Pneumothorax 38.87 11.80 124 782239 35161 109771775
Eyelid ptosis 38.84 11.80 23 782340 13304 109793632
Urosepsis 38.77 11.80 101 782262 30574 109776362
Peripheral arterial occlusive disease 38.77 11.80 9 782354 9271 109797665
Dermatitis bullous 38.75 11.80 40 782323 17489 109789447
Renal function test abnormal 38.74 11.80 8 782355 8938 109797998
Metabolic disorder 38.69 11.80 13 782350 10497 109796439
Hypovolaemic shock 38.66 11.80 28 782335 14555 109792381
Aplasia 38.65 11.80 5 782358 7868 109799068
Cervix carcinoma 38.58 11.80 66 782297 2435 109804501
Tooth infection 38.30 11.80 279 782084 21937 109784999
Gastrointestinal bacterial overgrowth 38.04 11.80 34 782329 629 109806307
Cerebral ischaemia 38.03 11.80 19 782344 12085 109794851
Rheumatoid lung 37.99 11.80 90 782273 4214 109802722
Rib fracture 37.68 11.80 118 782245 33652 109773284
Gait disturbance 37.52 11.80 1597 780766 276611 109530325
Sacroiliitis 37.52 11.80 98 782265 4880 109802056
Drug resistance 37.46 11.80 239 782124 56135 109750801
Normochromic normocytic anaemia 37.40 11.80 23 782340 13034 109793902
Duodenal ulcer haemorrhage 37.37 11.80 6 782357 8031 109798905
Muscle haemorrhage 37.24 11.80 3 782360 6866 109800070
Intestinal tuberculosis 37.23 11.80 24 782339 264 109806672
Performance status decreased 37.19 11.80 4 782359 7262 109799674
Guttate psoriasis 37.18 11.80 31 782332 520 109806416
Terminal state 37.16 11.80 106 782257 5561 109801375
Atypical mycobacterial infection 37.12 11.80 68 782295 2650 109804286
Growth retardation 37.05 11.80 66 782297 2516 109804420
Type IV hypersensitivity reaction 36.83 11.80 110 782253 5923 109801013
Product complaint 36.81 11.80 27 782336 13945 109792991
Oral mucosal blistering 36.72 11.80 6 782357 7928 109799008
Product monitoring error 36.62 11.80 9 782354 8918 109798018
Clostridium difficile colitis 36.56 11.80 172 782191 43606 109763330
Klebsiella infection 36.49 11.80 53 782310 19956 109786980
Drooling 36.36 11.80 4 782359 7135 109799801
Atrial tachycardia 36.22 11.80 10 782353 9168 109797768
Pathological fracture 36.16 11.80 20 782343 12012 109794924
Stress 36.14 11.80 989 781374 104359 109702577
Electrocardiogram ST segment elevation 36.12 11.80 10 782353 9150 109797786
Cholecystitis 36.05 11.80 81 782282 25801 109781135
Proctitis 36.04 11.80 224 782139 16703 109790233
Coronary artery occlusion 36.00 11.80 35 782328 15737 109791199
Rectal discharge 35.87 11.80 41 782322 1028 109805908
Eye irritation 35.85 11.80 119 782244 33333 109773603
Vaginal fistula 35.81 11.80 26 782337 352 109806584
Fistula repair 35.72 11.80 16 782347 77 109806859
Autoimmune haemolytic anaemia 35.67 11.80 15 782348 10552 109796384
Left ventricular failure 35.60 11.80 18 782345 11371 109795565
Eye pain 35.58 11.80 208 782155 49891 109757045
Colon dysplasia 35.50 11.80 26 782337 357 109806579
Faecaloma 35.31 11.80 32 782331 14876 109792060
Restless legs syndrome 35.18 11.80 76 782287 24550 109782386
Lung consolidation 35.15 11.80 15 782348 10461 109796475
Colostomy 35.10 11.80 47 782316 1391 109805545
Ankle arthroplasty 35.07 11.80 64 782299 2487 109804449
Anal fissure haemorrhage 34.95 11.80 18 782345 124 109806812
Transurethral prostatectomy 34.93 11.80 23 782340 263 109806673
Staphylococcal bacteraemia 34.77 11.80 40 782323 16648 109790288
Fear of injection 34.75 11.80 140 782223 8771 109798165
SARS-CoV-2 test positive 34.74 11.80 222 782141 16713 109790223
Vertigo 34.71 11.80 420 781943 86450 109720486
Nervous system disorder 34.58 11.80 112 782251 31609 109775327
Ophthalmic herpes zoster 34.42 11.80 75 782288 3320 109803616
Haemolysis 34.22 11.80 36 782327 15603 109791333
Sexual dysfunction 34.22 11.80 9 782354 8521 109798415
Drug screen positive 34.20 11.80 3 782360 6407 109800529
Vulval abscess 34.18 11.80 37 782326 872 109806064
Hepatomegaly 34.11 11.80 62 782301 21352 109785584
Ear injury 34.09 11.80 25 782338 344 109806592
Abortion spontaneous 34.09 11.80 382 781981 33900 109773036
Bone disorder 34.07 11.80 61 782302 21131 109785805
Haemorrhagic diathesis 34.03 11.80 6 782357 7502 109799434
Joint effusion 34.03 11.80 259 782104 20646 109786290
Epstein-Barr virus associated lymphoma 33.95 11.80 50 782313 1620 109805316
Venoocclusive disease 33.81 11.80 3 782360 6347 109800589
Hair follicle tumour benign 33.59 11.80 27 782336 429 109806507
Facial paralysis 33.54 11.80 76 782287 24138 109782798
Cytomegalovirus viraemia 33.44 11.80 46 782317 17718 109789218
Faecal calprotectin decreased 33.43 11.80 16 782347 92 109806844
Ostomy bag placement 33.24 11.80 13 782350 41 109806895
Rectal cancer 33.19 11.80 79 782284 3710 109803226
Gastritis erosive 33.19 11.80 22 782341 11978 109794958
Chondropathy 33.02 11.80 67 782296 2820 109804116
Sleep terror 32.93 11.80 4 782359 6606 109800330
Rash morbilliform 32.65 11.80 8 782355 7943 109798993
Conjunctivitis allergic 32.62 11.80 5 782358 6926 109800010
Finger deformity 32.57 11.80 368 781995 32724 109774212
Spinal osteoarthritis 32.54 11.80 58 782305 20125 109786811
Coma scale abnormal 32.52 11.80 14 782349 9712 109797224
Endotracheal intubation 32.45 11.80 3 782360 6141 109800795
Euphoric mood 32.35 11.80 11 782352 8816 109798120
Gastrointestinal mucosa hyperaemia 32.34 11.80 29 782334 539 109806397
Anti-cyclic citrullinated peptide antibody 32.31 11.80 247 782116 19717 109787219
Hypertriglyceridaemia 32.29 11.80 40 782323 16114 109790822
Blood pressure abnormal 32.20 11.80 69 782294 22355 109784581
Gastroenteritis salmonella 32.14 11.80 44 782319 1331 109805605
Postoperative abscess 32.08 11.80 36 782327 884 109806052
Caesarean section 32.06 11.80 187 782176 13630 109793306
Suffocation feeling 32.02 11.80 55 782308 2036 109804900
Embolism 31.87 11.80 41 782322 16248 109790688
Adverse reaction 31.84 11.80 335 782028 29259 109777677
Fracture 31.80 11.80 81 782282 24707 109782229
Catheter site erythema 31.68 11.80 3 782360 6025 109800911
Cystitis haemorrhagic 31.64 11.80 24 782339 12185 109794751
Wrist surgery 31.63 11.80 35 782328 846 109806090
Dysstasia 31.60 11.80 123 782240 32863 109774073
Back pain 31.54 11.80 2229 780134 368767 109438169
Dust allergy 31.51 11.80 3 782360 5998 109800938
Splenomegaly 31.47 11.80 80 782283 24418 109782518
Renal tubular disorder 31.45 11.80 7 782356 7422 109799514
Spinal column injury 31.44 11.80 58 782305 2273 109804663
Fistula inflammation 31.35 11.80 10 782353 13 109806923
Neutrophilia 31.28 11.80 17 782346 10312 109796624
Nephrotic syndrome 31.22 11.80 31 782332 13800 109793136
Ventricular hypertrophy 31.14 11.80 6 782357 7039 109799897
Extrasystoles 31.12 11.80 10 782353 8308 109798628
Spleen tuberculosis 31.12 11.80 12 782351 36 109806900
Malignant respiratory tract neoplasm 30.98 11.80 11 782352 24 109806912
Eye movement disorder 30.97 11.80 15 782348 9713 109797223
Joint dislocation 30.89 11.80 374 781989 33816 109773120
Obliterative bronchiolitis 30.88 11.80 76 782287 3647 109803289
Blood magnesium decreased 30.87 11.80 59 782304 19937 109786999
Lung disorder 30.87 11.80 1564 780799 178483 109628453
Pyoderma 30.85 11.80 28 782335 529 109806407
Neurological symptom 30.83 11.80 39 782324 15569 109791367
Blood creatinine abnormal 30.79 11.80 3 782360 5889 109801047
Blood pressure inadequately controlled 30.73 11.80 8 782355 7625 109799311
Omphalitis 30.67 11.80 18 782345 165 109806771
Dermatitis contact 30.67 11.80 32 782331 13921 109793015
Pseudopolyposis 30.62 11.80 16 782347 114 109806822
Spinal fracture 30.58 11.80 72 782291 22561 109784375
Abnormal faeces 30.52 11.80 138 782225 9098 109797838
Large intestinal ulcer 30.52 11.80 100 782263 5661 109801275
Post-traumatic stress disorder 30.50 11.80 5 782358 6591 109800345
Self-medication 30.49 11.80 4 782359 6228 109800708
Neoplasm skin 30.48 11.80 69 782294 3135 109803801
Dizziness postural 30.46 11.80 35 782328 14574 109792362
Tension headache 30.36 11.80 15 782348 9603 109797333
Pseudomonal sepsis 30.28 11.80 13 782350 9033 109797903
Pulmonary vasculitis 30.27 11.80 5 782358 6555 109800381
Sinus congestion 30.20 11.80 112 782251 30347 109776589
Hyperhidrosis 30.11 11.80 1053 781310 186245 109620691
Device failure 30.09 11.80 7 782356 7200 109799736
Neurogenic shock 29.96 11.80 35 782328 899 109806037
Carotid artery stenosis 29.92 11.80 14 782349 9249 109797687
Lacrimation increased 29.91 11.80 115 782248 30835 109776101
Rash papular 29.84 11.80 98 782265 27541 109779395
Underdose 29.83 11.80 623 781740 62931 109744005
Fine motor skill dysfunction 29.80 11.80 105 782258 6169 109800767
Amenorrhoea 29.75 11.80 14 782349 9217 109797719
Liver function test increased 29.73 11.80 829 781534 87719 109719217
Cell marker increased 29.69 11.80 30 782333 651 109806285
Respiratory alkalosis 29.67 11.80 3 782360 5718 109801218
Incoherent 29.63 11.80 11 782352 8347 109798589
Presyncope 29.62 11.80 213 782150 48674 109758262
Peritonsillar abscess 29.61 11.80 37 782326 1021 109805915
Occult blood positive 29.59 11.80 8 782355 7437 109799499
Premature labour 29.53 11.80 136 782227 9036 109797900
Spinal compression fracture 29.52 11.80 53 782310 18339 109788597
Rhinovirus infection 29.51 11.80 24 782339 11765 109795171
Rash macular 29.44 11.80 157 782206 38529 109768407
Areflexia 29.43 11.80 6 782357 6763 109800173
Eosinophil count decreased 29.12 11.80 4 782359 6014 109800922
Pus in stool 29.11 11.80 13 782350 62 109806874
Peritonitis 29.10 11.80 125 782238 32482 109774454
Blood chloride increased 29.09 11.80 5 782358 6367 109800569
Testicular seminoma (pure) 29.05 11.80 17 782346 155 109806781
Haemothorax 29.02 11.80 7 782356 7024 109799912
International normalised ratio abnormal 28.99 11.80 5 782358 6352 109800584
Small intestinal obstruction 28.94 11.80 352 782011 31861 109775075
Extra dose administered 28.91 11.80 26 782337 12133 109794803
Short stature 28.82 11.80 37 782326 1050 109805886
Tonsillar ulcer 28.71 11.80 25 782338 446 109806490
Product availability issue 28.62 11.80 10 782353 7880 109799056
Eye infection bacterial 28.62 11.80 24 782339 406 109806530
Atrioventricular block second degree 28.61 11.80 11 782352 8170 109798766
Conjunctival haemorrhage 28.59 11.80 6 782357 6627 109800309
Granuloma 28.57 11.80 138 782225 9352 109797584
Lacunar infarction 28.54 11.80 5 782358 6281 109800655
Compartment syndrome 28.42 11.80 4 782359 5906 109801030
Vitamin D deficiency 28.41 11.80 55 782308 18497 109788439
Obsessive-compulsive disorder 28.37 11.80 8 782355 7233 109799703
Blood thyroid stimulating hormone decreased 28.36 11.80 8 782355 7231 109799705
Axial spondyloarthritis 28.33 11.80 33 782330 845 109806091
Brain death 28.22 11.80 6 782357 6567 109800369
Prescription drug used without a prescription 28.20 11.80 3 782360 5493 109801443
Sensitivity to weather change 28.19 11.80 143 782220 9885 109797051
Terminal ileitis 28.06 11.80 46 782317 1638 109805298
Hypoventilation 28.04 11.80 11 782352 8070 109798866
Red cell distribution width decreased 28.04 11.80 54 782309 2187 109804749
Supraventricular extrasystoles 28.00 11.80 11 782352 8062 109798874
Gastrointestinal stenosis 27.82 11.80 23 782340 381 109806555
Lung squamous cell carcinoma recurrent 27.81 11.80 10 782353 23 109806913
Product administered to patient of inappropriate age 27.78 11.80 11 782352 8025 109798911
Vaginal abscess 27.73 11.80 25 782338 468 109806468
Coccidioidomycosis 27.66 11.80 45 782318 1592 109805344
Total lung capacity decreased 27.62 11.80 8 782355 7106 109799830
Facial pain 27.61 11.80 41 782322 15298 109791638
Urine abnormality 27.51 11.80 15 782348 9081 109797855
Palmoplantar keratoderma 27.49 11.80 3 782360 5384 109801552
Social avoidant behaviour 27.37 11.80 3 782360 5366 109801570
Intervertebral disc degeneration 27.37 11.80 54 782309 18031 109788905
Anastomotic stenosis 27.35 11.80 29 782334 667 109806269
Blood phosphorus decreased 27.32 11.80 10 782353 7655 109799281
Sleep disorder 27.30 11.80 1691 780672 196953 109609983
High density lipoprotein decreased 27.29 11.80 4 782359 5729 109801207
Carotid artery occlusion 27.19 11.80 17 782346 9548 109797388
Ocular icterus 27.09 11.80 5 782358 6048 109800888
Vaginal haemorrhage 27.01 11.80 89 782274 24985 109781951
Laryngitis 27.00 11.80 436 781927 41975 109764961
Epstein-Barr virus associated lymphoproliferative disorder 26.93 11.80 85 782278 4717 109802219
Gastrointestinal fistula 26.91 11.80 34 782329 949 109805987
Hyperaesthesia 26.87 11.80 39 782324 14688 109792248
Lung transplant 26.83 11.80 3 782360 5283 109801653
Ileal ulcer 26.79 11.80 47 782316 1770 109805166
Parainfluenzae virus infection 26.79 11.80 8 782355 6966 109799970
Respiratory syncytial virus infection 26.78 11.80 38 782325 14446 109792490
Sudden cardiac death 26.68 11.80 4 782359 5633 109801303
Osteopenia 26.66 11.80 75 782288 22134 109784802
Genital haemorrhage 26.64 11.80 9 782354 7243 109799693
Insomnia 26.62 11.80 2192 780171 358398 109448538
Cerebellar syndrome 26.55 11.80 6 782357 6296 109800640
Lupus vasculitis 26.53 11.80 27 782336 591 109806345
Alopecia areata 26.51 11.80 52 782311 2135 109804801
Mycobacterial infection 26.46 11.80 80 782283 4337 109802599
Emotional disorder 26.45 11.80 46 782317 16114 109790822
Oral pain 26.31 11.80 156 782207 37288 109769648
Cellulitis 26.30 11.80 684 781679 125332 109681604
Cryptitis 26.29 11.80 22 782341 371 109806565
Kounis syndrome 26.29 11.80 5 782358 5920 109801016
Metastases to lymph nodes 26.27 11.80 41 782322 14991 109791945
Distributive shock 26.16 11.80 5 782358 5899 109801037
Blood urine present 26.16 11.80 86 782277 24159 109782777
Hepatitis fulminant 26.06 11.80 14 782349 8546 109798390
Cerebral atrophy 26.03 11.80 16 782347 9069 109797867
Anaphylactic reaction 25.99 11.80 1022 781341 113278 109693658
Brachiocephalic artery stenosis 25.93 11.80 10 782353 30 109806906
Blood iron decreased 25.86 11.80 228 782135 18986 109787950
Intraventricular haemorrhage 25.86 11.80 4 782359 5503 109801433
Incorrect dose administered by device 25.84 11.80 8 782355 6806 109800130
Drug exposure before pregnancy 25.83 11.80 28 782335 661 109806275
Sinus node dysfunction 25.82 11.80 16 782347 9031 109797905
Colon injury 25.81 11.80 22 782341 381 109806555
Lupus vulgaris 25.72 11.80 359 782004 33524 109773412
Sensory disturbance 25.55 11.80 53 782310 17376 109789560
Heavy menstrual bleeding 25.52 11.80 48 782315 16317 109790619
Troponin I increased 25.51 11.80 4 782359 5448 109801488
Joint injury 25.40 11.80 411 781952 39583 109767353
Autonomic nervous system imbalance 25.38 11.80 5 782358 5775 109801161
Mastitis 25.36 11.80 56 782307 2502 109804434
Hodgkin's disease nodular sclerosis 25.24 11.80 9 782354 20 109806916
Drug abuser 25.23 11.80 4 782359 5405 109801531
Nail operation 25.21 11.80 44 782319 1650 109805286
Product physical issue 25.20 11.80 3 782360 5033 109801903
Bone cyst 25.20 11.80 69 782294 3534 109803402
Renal cyst 25.20 11.80 57 782306 18115 109788821
Ileostomy closure 25.20 11.80 21 782342 352 109806584
Dental caries 25.15 11.80 32 782331 12741 109794195
Product prescribing issue 25.14 11.80 32 782331 12740 109794196
Bronchial secretion retention 25.13 11.80 3 782360 5021 109801915
Escherichia bacteraemia 25.06 11.80 21 782342 10143 109796793
Diabetes mellitus 25.05 11.80 524 781839 98857 109708079
Portal hypertension 25.04 11.80 15 782348 8622 109798314
Initial insomnia 24.96 11.80 22 782341 10367 109796569
Subacute cutaneous lupus erythematosus 24.93 11.80 3 782360 4991 109801945
Ileus 24.92 11.80 122 782241 30607 109776329
Scleroderma 24.86 11.80 7 782356 6334 109800602
Depression 24.82 11.80 1920 780443 315415 109491521
Intra-abdominal haemorrhage 24.81 11.80 4 782359 5338 109801598
Lung infiltration 24.78 11.80 90 782273 24538 109782398
Anaphylactic shock 24.69 11.80 239 782124 51307 109755629
Bladder neoplasm 24.68 11.80 47 782316 1887 109805049
Inhibitory drug interaction 24.63 11.80 3 782360 4944 109801992
Ischaemic cardiomyopathy 24.53 11.80 13 782350 7998 109798938
Transplant failure 24.49 11.80 5 782358 5630 109801306
Libido decreased 24.31 11.80 6 782357 5929 109801007
Neck deformity 24.28 11.80 46 782317 1840 109805096
Smear cervix abnormal 24.25 11.80 57 782306 2655 109804281
Hepatitis C 24.24 11.80 32 782331 12541 109794395
Coronary arterial stent insertion 24.19 11.80 6 782357 5909 109801027
Meningitis tuberculous 24.18 11.80 37 782326 1241 109805695
Cardiac dysfunction 24.15 11.80 7 782356 6216 109800720
Bacteraemia 24.11 11.80 188 782175 42202 109764734
Foetal death 24.03 11.80 195 782168 15850 109791086
Gastrointestinal stoma complication 24.03 11.80 64 782299 3225 109803711
Chronic graft versus host disease 23.99 11.80 19 782344 9438 109797498
Cardiopulmonary failure 23.95 11.80 13 782350 7890 109799046
Protein total decreased 23.91 11.80 25 782338 10865 109796071
Gastrooesophageal reflux disease 23.86 11.80 1035 781328 178941 109627995
Hepatic necrosis 23.85 11.80 21 782342 9901 109797035
Haemarthrosis 23.80 11.80 11 782352 7318 109799618
Skin abrasion 23.78 11.80 49 782314 16102 109790834
Failure to thrive 23.74 11.80 37 782326 13537 109793399
Exostosis 23.74 11.80 457 781906 45499 109761437
Anger 23.70 11.80 63 782300 18944 109787992
Oral discomfort 23.69 11.80 27 782336 11284 109795652
Burns second degree 23.68 11.80 113 782250 7620 109799316
Musculoskeletal disorder 23.66 11.80 255 782108 22409 109784527
Hypersomnia 23.58 11.80 110 782253 27951 109778985
Dysphoria 23.57 11.80 8 782355 6420 109800516
Torus fracture 23.53 11.80 14 782349 132 109806804
Lower respiratory tract infection viral 23.52 11.80 39 782324 1402 109805534
Vaginal infection 23.49 11.80 103 782260 6701 109800235
Enterocolitis 23.49 11.80 63 782300 18886 109788050
Antibody test abnormal 23.45 11.80 33 782330 1025 109805911
Leishmaniasis 23.25 11.80 23 782340 486 109806450
Anal ulcer 23.22 11.80 45 782318 1831 109805105
Retroperitoneal haemorrhage 23.22 11.80 7 782356 6058 109800878
Sputum increased 23.20 11.80 6 782357 5745 109801191
Neurogenic bladder 23.15 11.80 4 782359 5075 109801861
Renal tubular acidosis 23.13 11.80 3 782360 4712 109802224
Epicondylitis 23.11 11.80 54 782309 2506 109804430
Tachyarrhythmia 23.04 11.80 15 782348 8246 109798690
Fistula of small intestine 23.04 11.80 33 782330 1042 109805894
Blood immunoglobulin G decreased 23.04 11.80 5 782358 5395 109801541
Mouth ulceration 22.96 11.80 473 781890 47665 109759271
Prostatic specific antigen increased 22.95 11.80 33 782330 12478 109794458
Anorectal stenosis 22.85 11.80 10 782353 45 109806891
Non-cardiac chest pain 22.85 11.80 23 782340 10175 109796761
Small intestine operation 22.85 11.80 10 782353 45 109806891
Blood glucose fluctuation 22.84 11.80 13 782350 7685 109799251
Angiopathy 22.83 11.80 17 782346 8713 109798223
Skin ulcer 22.83 11.80 601 781762 63044 109743892
Anosmia 22.78 11.80 33 782330 12439 109794497
Polyomavirus-associated nephropathy 22.73 11.80 15 782348 8186 109798750
Injection site nodule 22.69 11.80 3 782360 4643 109802293
Hodgkin's disease stage II 22.67 11.80 8 782355 17 109806919
Circumcision 22.64 11.80 9 782354 30 109806906
Diffuse large B-cell lymphoma 22.63 11.80 191 782172 15707 109791229
Nasal oedema 22.62 11.80 10 782353 6829 109800107
Intercepted product preparation error 22.51 11.80 10 782353 6810 109800126
Immunosuppression 22.50 11.80 208 782155 17551 109789385
Diverticulum intestinal 22.41 11.80 30 782333 11689 109795247
Abscess limb 22.38 11.80 119 782244 8378 109798558
Application site erythema 22.35 11.80 6 782357 5604 109801332
Porphyria acute 22.33 11.80 217 782146 18563 109788373
Nephrogenic anaemia 22.24 11.80 3 782360 4574 109802362
Internal haemorrhage 22.24 11.80 23 782340 10048 109796888
Brain herniation 22.24 11.80 18 782345 8845 109798091
Gastric perforation 22.21 11.80 4 782359 4925 109802011
Chronic disease 22.14 11.80 16 782347 215 109806721
Eructation 22.12 11.80 41 782322 14016 109792920
Ischaemia 22.11 11.80 19 782344 9064 109797872
Temperature regulation disorder 22.06 11.80 161 782202 12665 109794271
Small intestine carcinoma 22.05 11.80 33 782330 1085 109805851
Malignant melanoma stage I 22.03 11.80 14 782349 150 109806786
Anorectal ulcer 22.02 11.80 10 782353 50 109806886
Stenotrophomonas infection 21.99 11.80 7 782356 5851 109801085
Bicytopenia 21.97 11.80 10 782353 6714 109800222
Congestive hepatopathy 21.93 11.80 5 782358 5215 109801721
Venous injury 21.93 11.80 31 782332 967 109805969
Lumbar spinal stenosis 21.93 11.80 9 782354 6424 109800512
Residual urine volume increased 21.92 11.80 12 782351 95 109806841
Blood sodium increased 21.83 11.80 6 782357 5517 109801419
Enteropathic spondylitis 21.79 11.80 9 782354 34 109806902
Retinal haemorrhage 21.79 11.80 21 782342 9480 109797456
Pneumocystis jirovecii pneumonia 21.74 11.80 424 781939 42311 109764625
Memory impairment 21.68 11.80 1155 781208 195789 109611147
Arthritis bacterial 21.68 11.80 141 782222 10679 109796257
Varices oesophageal 21.67 11.80 12 782351 7203 109799733
Upper respiratory tract infection 21.64 11.80 736 781627 130592 109676344
Thoracic vertebral fracture 21.59 11.80 10 782353 6645 109800291
Inadequate diet 21.58 11.80 18 782345 302 109806634
Blood culture positive 21.58 11.80 19 782344 8957 109797979
Colon cancer 21.55 11.80 194 782169 16249 109790687
Mouth haemorrhage 21.53 11.80 39 782324 13449 109793487
Large intestine operation 21.51 11.80 8 782355 21 109806915
Injection site haematoma 21.48 11.80 5 782358 5141 109801795
Leukoencephalopathy 21.46 11.80 20 782343 9175 109797761
Enterococcal infection 21.45 11.80 73 782290 20293 109786643
Feeling jittery 21.39 11.80 45 782318 14677 109792259
Taste disorder 21.34 11.80 610 781753 64777 109742159
Takayasu's arteritis 21.34 11.80 6 782357 3 109806933
Hepatocellular carcinoma 21.33 11.80 23 782340 9857 109797079
Middle insomnia 21.25 11.80 74 782289 20428 109786508
Hyperthermia 21.23 11.80 78 782285 21194 109785742
Depressive symptom 21.22 11.80 17 782346 8397 109798539
Diverticulum intestinal haemorrhagic 21.17 11.80 4 782359 4759 109802177
Lumbar vertebral fracture 21.15 11.80 20 782343 9111 109797825
Hereditary angioedema 21.13 11.80 12 782351 7102 109799834
Hospitalisation 21.12 11.80 809 781554 141684 109665252
Skin atrophy 21.08 11.80 10 782353 6554 109800382
Drug dependence 21.08 11.80 239 782124 49781 109757155
Platelet count abnormal 21.07 11.80 9 782354 6273 109800663
Vitamin B12 deficiency 21.06 11.80 24 782339 10031 109796905
Congestive cardiomyopathy 21.05 11.80 43 782320 14176 109792760
Arteriospasm coronary 21.00 11.80 20 782343 9080 109797856
Essential hypertension 20.89 11.80 15 782348 7832 109799104
Sickle cell anaemia with crisis 20.86 11.80 22 782341 9523 109797413
Coronavirus infection 20.86 11.80 22 782341 9523 109797413
Pneumomediastinum 20.81 11.80 5 782358 5031 109801905
Therapy change 20.79 11.80 24 782339 9973 109796963
Skin plaque 20.77 11.80 157 782206 12488 109794448
Proctitis ulcerative 20.73 11.80 21 782342 457 109806479
Cytomegalovirus mononucleosis 20.71 11.80 6 782357 4 109806932
Enterocolonic fistula 20.70 11.80 14 782349 168 109806768
Root canal infection 20.70 11.80 21 782342 458 109806478
Salpingectomy 20.68 11.80 18 782345 321 109806615
Enterovesical fistula 20.67 11.80 37 782326 1416 109805520
Thrombosis in device 20.66 11.80 6 782357 5321 109801615
Petit mal epilepsy 20.65 11.80 14 782349 7533 109799403
Adenocarcinoma 20.65 11.80 72 782291 4208 109802728
Perineal abscess 20.61 11.80 27 782336 782 109806154
Central nervous system lesion 20.60 11.80 50 782313 15503 109791433
Oesophageal carcinoma 20.55 11.80 31 782332 11493 109795443
White blood cells urine positive 20.53 11.80 14 782349 7510 109799426
Overweight 20.53 11.80 10 782353 6454 109800482
Haemolytic uraemic syndrome 20.50 11.80 5 782358 4980 109801956
Tuberculosis of central nervous system 20.44 11.80 22 782341 515 109806421
Fluid intake reduced 20.44 11.80 12 782351 6974 109799962
Tongue oedema 20.43 11.80 17 782346 8239 109798697
Tuberculosis of eye 20.42 11.80 11 782352 84 109806852
Drainage 20.40 11.80 16 782347 245 109806691
Therapeutic reaction time decreased 20.38 11.80 6 782357 5273 109801663
Stenosis 20.36 11.80 61 782302 3290 109803646
Tonsillitis streptococcal 20.35 11.80 14 782349 173 109806763
Oesophageal varices haemorrhage 20.26 11.80 5 782358 4940 109801996
Body height decreased 20.24 11.80 27 782336 10536 109796400
Mucosal dryness 20.24 11.80 3 782360 4260 109802676
Product substitution issue 20.21 11.80 89 782274 22972 109783964
Retinal artery occlusion 20.15 11.80 3 782360 4246 109802690
Blood parathyroid hormone increased 20.14 11.80 3 782360 4245 109802691
Disease complication 20.11 11.80 8 782355 5819 109801117
Blood albumin decreased 20.07 11.80 114 782249 27538 109779398
Tendonitis 20.06 11.80 277 782086 25806 109781130
Blood pressure systolic increased 20.04 11.80 747 781616 82244 109724692
Infected cyst 20.03 11.80 36 782327 1382 109805554
Pulmonary thrombosis 19.97 11.80 167 782196 13696 109793240
Gastrointestinal carcinoma 19.96 11.80 62 782301 3411 109803525
Paraparesis 19.95 11.80 4 782359 4562 109802374
Short-bowel syndrome 19.93 11.80 26 782337 750 109806186
Tooth abscess 19.89 11.80 212 782151 18577 109788359
Abnormal loss of weight 19.88 11.80 26 782337 10231 109796705
Impetigo 19.81 11.80 51 782312 2517 109804419
Anal dilatation 19.79 11.80 5 782358 0 109806936
Bladder repair 19.77 11.80 10 782353 66 109806870
Ecchymosis 19.76 11.80 60 782303 17278 109789658
Psychiatric decompensation 19.75 11.80 8 782355 5757 109801179
Lung neoplasm malignant 19.74 11.80 343 782020 33499 109773437
Poor quality sleep 19.71 11.80 117 782246 27960 109778976
Hernia 19.71 11.80 218 782145 19282 109787654
Hyporeflexia 19.58 11.80 3 782360 4157 109802779
Paronychia 19.58 11.80 30 782333 11051 109795885
Parathyroid disorder 19.53 11.80 24 782339 651 109806285
Renal colic 19.51 11.80 59 782304 3199 109803737
Faecal calprotectin 19.49 11.80 11 782352 93 109806843
Tuberculosis liver 19.49 11.80 11 782352 93 109806843
Palpitations 19.40 11.80 924 781439 158288 109648648
Anaemia macrocytic 19.39 11.80 14 782349 7289 109799647
Cytomegalovirus enterocolitis 19.38 11.80 47 782316 2234 109804702
Spinal cord compression 19.37 11.80 15 782348 7537 109799399
Culture urine positive 19.36 11.80 5 782358 4791 109802145
Furuncle 19.27 11.80 116 782247 8552 109798384
Febrile infection 19.22 11.80 4 782359 4444 109802492
Diabetic foot 19.17 11.80 3 782360 4092 109802844
Multiple sclerosis 19.16 11.80 105 782258 25593 109781343
Diabetic neuropathy 19.13 11.80 13 782350 6986 109799950
Seronegative arthritis 19.12 11.80 159 782204 13018 109793918
Escherichia infection 19.06 11.80 95 782268 23721 109783215
Non-consummation 19.06 11.80 9 782354 50 109806886
Systolic dysfunction 19.01 11.80 4 782359 4411 109802525
Incorrect dosage administered 18.98 11.80 66 782297 3852 109803084
Catheter site pain 18.96 11.80 11 782352 6435 109800501
Communication disorder 18.96 11.80 6 782357 5033 109801903
Electroencephalogram abnormal 18.93 11.80 10 782353 6163 109800773
Allergic fungal rhinosinusitis 18.91 11.80 9 782354 51 109806885
Cutaneous lupus erythematosus 18.89 11.80 61 782302 3427 109803509
Dysgraphia 18.81 11.80 5 782358 4700 109802236
Lymphocyte percentage decreased 18.81 11.80 7 782356 5303 109801633
Blood pressure systolic decreased 18.77 11.80 42 782321 13399 109793537
Increased tendency to bruise 18.77 11.80 34 782329 11724 109795212
Seminoma 18.72 11.80 16 782347 278 109806658
Intestinal malrotation 18.72 11.80 6 782357 8 109806928
C-reactive protein decreased 18.67 11.80 54 782309 2855 109804081
Pupillary reflex impaired 18.66 11.80 3 782360 4012 109802924
Wrong technique in device usage process 18.62 11.80 13 782350 6888 109800048
Urine analysis abnormal 18.60 11.80 13 782350 6884 109800052
Blood pH decreased 18.59 11.80 5 782358 4664 109802272
Breast cancer stage I 18.54 11.80 15 782348 7372 109799564
Peripheral ischaemia 18.54 11.80 31 782332 11027 109795909
Disseminated coccidioidomycosis 18.52 11.80 15 782348 241 109806695
Logorrhoea 18.48 11.80 6 782357 4951 109801985
Haemoglobin abnormal 18.47 11.80 22 782341 9016 109797920
Aortic valve stenosis 18.45 11.80 11 782352 6339 109800597
Enterobacter infection 18.44 11.80 9 782354 5802 109801134
Pulmonary toxicity 18.43 11.80 64 782299 17682 109789254
Hydrocephalus 18.42 11.80 28 782335 10347 109796589
Thrombotic thrombocytopenic purpura 18.40 11.80 14 782349 7097 109799839
Adhesiolysis 18.40 11.80 7 782356 20 109806916
Blood bicarbonate decreased 18.36 11.80 9 782354 5788 109801148
Genital cyst 18.36 11.80 9 782354 55 109806881
Neoplasm recurrence 18.36 11.80 7 782356 5225 109801711
Bradyarrhythmia 18.34 11.80 6 782357 4928 109802008
Laryngeal cancer 18.31 11.80 25 782338 754 109806182
Breath sounds abnormal 18.29 11.80 105 782258 25299 109781637
Pericardial haemorrhage 18.27 11.80 7 782356 5210 109801726
Oligoarthritis 18.26 11.80 25 782338 756 109806180
Pneumatosis intestinalis 18.26 11.80 20 782343 8509 109798427
Application site pain 18.25 11.80 8 782355 5491 109801445
Groin abscess 18.24 11.80 42 782321 1930 109805006
Bacterial infection 18.23 11.80 223 782140 45813 109761123
Capillary leak syndrome 18.19 11.80 6 782357 4902 109802034
Immune recovery uveitis 18.17 11.80 12 782351 138 109806798
Anorectal swelling 18.17 11.80 12 782351 138 109806798
Post procedural haemorrhage 18.17 11.80 53 782310 15459 109791477
Intracranial pressure increased 18.16 11.80 29 782334 10506 109796430
Catarrh 18.16 11.80 101 782262 7234 109799702
Neoplasm prostate 18.16 11.80 13 782350 172 109806764
Gastrointestinal cancer metastatic 18.14 11.80 14 782349 209 109806727
Serum sickness-like reaction 18.09 11.80 25 782338 763 109806173
Electrocardiogram ST segment depression 18.04 11.80 8 782355 5453 109801483
Screaming 18.03 11.80 6 782357 4875 109802061
Deafness neurosensory 18.02 11.80 25 782338 9594 109797342
Snoring 18.02 11.80 13 782350 6771 109800165
Hypermobility syndrome 17.99 11.80 21 782342 539 109806397
Catheter site infection 17.98 11.80 18 782345 7982 109798954
Ventricular dysfunction 17.93 11.80 16 782347 7495 109799441
Stress at work 17.91 11.80 33 782330 1292 109805644
Metastatic malignant melanoma 17.90 11.80 59 782304 3350 109803586
Stomal hernia 17.90 11.80 21 782342 542 109806394
Crying 17.88 11.80 107 782256 25521 109781415
Chest pain 17.83 11.80 2361 780002 374014 109432922
Prescribed underdose 17.81 11.80 595 781768 64579 109742357
Electrocardiogram T wave abnormal 17.80 11.80 4 782359 4213 109802723
Blood immunoglobulin E increased 17.79 11.80 16 782347 7466 109799470
Chloropsia 17.78 11.80 8 782355 39 109806897
Pain of skin 17.74 11.80 77 782286 19952 109786984
Photopsia 17.72 11.80 11 782352 6203 109800733
Hypoproteinaemia 17.69 11.80 10 782353 5935 109801001
Rhonchi 17.69 11.80 5 782358 4513 109802423
Procedural complication 17.67 11.80 20 782343 8385 109798551
Craniocerebral injury 17.64 11.80 10 782353 5924 109801012
Monocyte count decreased 17.63 11.80 3 782360 3848 109803088
Lip neoplasm malignant stage unspecified 17.62 11.80 8 782355 40 109806896
Focal dyscognitive seizures 17.61 11.80 3 782360 3846 109803090
Cerebellar infarction 17.61 11.80 4 782359 4183 109802753
Unintended pregnancy 17.61 11.80 6 782357 4802 109802134
Herpes ophthalmic 17.60 11.80 40 782323 1822 109805114
Major depression 17.60 11.80 30 782333 10591 109796345
Compression fracture 17.59 11.80 24 782339 9275 109797661
Varicella post vaccine 17.58 11.80 6 782357 11 109806925
Language disorder 17.54 11.80 3 782360 3835 109803101
Gastrointestinal wall thickening 17.52 11.80 61 782302 3562 109803374
Dyschezia 17.47 11.80 63 782300 3744 109803192
Vulval neoplasm 17.46 11.80 5 782358 3 109806933
Galactorrhoea 17.42 11.80 4 782359 4151 109802785
Peripheral vascular disorder 17.39 11.80 21 782342 8555 109798381
Diverticulitis 17.38 11.80 499 781864 53023 109753913
Colonoscopy abnormal 17.36 11.80 13 782350 185 109806751
Mycobacterium avium complex infection 17.36 11.80 85 782278 5792 109801144
Hypoaesthesia 17.35 11.80 2506 779857 311717 109495219
Gastroenteritis viral 17.33 11.80 314 782049 30912 109776024
Mean cell volume increased 17.32 11.80 20 782343 8310 109798626
Eye infection toxoplasmal 17.28 11.80 24 782339 736 109806200
Micturition urgency 17.28 11.80 74 782289 19246 109787690
Skin erosion 17.20 11.80 10 782353 5844 109801092
Colostomy closure 17.13 11.80 12 782351 153 109806783
Visual field defect 17.10 11.80 28 782335 10044 109796892
Fibrin D dimer increased 17.06 11.80 27 782336 9818 109797118
Enuresis 17.06 11.80 4 782359 4092 109802844
Carcinoma in situ of skin 17.02 11.80 13 782350 191 109806745
Cyst 16.94 11.80 185 782178 16311 109790625
Kidney fibrosis 16.94 11.80 5 782358 4387 109802549
Product dispensing error 16.94 11.80 59 782304 16286 109790650
Acute coronary syndrome 16.93 11.80 95 782268 23017 109783919
Fistulotomy 16.93 11.80 6 782357 13 109806923
Plasmacytoma 16.93 11.80 8 782355 5254 109801682
Linear IgA disease 16.92 11.80 5 782358 4384 109802552
Respiration abnormal 16.91 11.80 27 782336 9782 109797154
Drain removal 16.88 11.80 5 782358 4 109806932
Mental disorder 16.88 11.80 184 782179 38607 109768329
Vitreous floaters 16.85 11.80 24 782339 9110 109797826
Secondary immunodeficiency 16.84 11.80 6 782357 4670 109802266
Secretion discharge 16.81 11.80 218 782145 20026 109786910
Postoperative wound infection 16.80 11.80 178 782185 15575 109791361
Post procedural discharge 16.75 11.80 24 782339 758 109806178
Dysphemia 16.70 11.80 4 782359 4033 109802903
Disease susceptibility 16.68 11.80 16 782347 325 109806611
Inflammatory pain 16.54 11.80 35 782328 1518 109805418
Refusal of treatment by patient 16.49 11.80 26 782337 9468 109797468
Orbital apex syndrome 16.48 11.80 10 782353 98 109806838
Episcleritis 16.45 11.80 31 782332 1235 109805701
Angiolymphoid hyperplasia with eosinophilia 16.40 11.80 11 782352 130 109806806
Hypertensive heart disease 16.38 11.80 6 782357 4590 109802346
Reduced facial expression 16.37 11.80 3 782360 3648 109803288
Lip ulceration 16.34 11.80 50 782313 2728 109804208
Mean platelet volume decreased 16.34 11.80 56 782307 3244 109803692
Anti-saccharomyces cerevisiae antibody 16.34 11.80 6 782357 15 109806921
Stoma site rash 16.34 11.80 6 782357 15 109806921
Procedural haemorrhage 16.34 11.80 9 782354 5418 109801518
Mineral supplementation 16.31 11.80 25 782338 840 109806096
Urine odour abnormal 16.30 11.80 17 782346 7398 109799538
Intermenstrual bleeding 16.28 11.80 15 782348 6919 109800017
Polymyalgia rheumatica 16.27 11.80 13 782350 6429 109800507
Psychiatric symptom 16.22 11.80 25 782338 9188 109797748
Intestinal anastomosis complication 16.21 11.80 17 782346 386 109806550
Anal skin tags 16.20 11.80 20 782343 545 109806391
Muscle tightness 16.18 11.80 52 782311 14710 109792226
Post procedural infection 16.14 11.80 159 782204 13650 109793286
Jejunal stenosis 16.05 11.80 11 782352 135 109806801
Cytomegalovirus enteritis 16.04 11.80 28 782335 1050 109805886
Intervertebral disc space narrowing 16.04 11.80 39 782324 1857 109805079
Gingival bleeding 15.95 11.80 79 782284 19760 109787176
Escherichia test positive 15.95 11.80 3 782360 3581 109803355
Skin tightness 15.92 11.80 10 782353 5603 109801333
Sluggishness 15.92 11.80 18 782345 7549 109799387
Anaplastic large-cell lymphoma 15.89 11.80 13 782350 212 109806724
Facial paresis 15.86 11.80 12 782351 6101 109800835
Eye laser surgery 15.86 11.80 9 782354 77 109806859
Rotator cuff syndrome 15.85 11.80 63 782300 16731 109790205
Anal dilation procedure 15.83 11.80 4 782359 0 109806936
Food allergy 15.81 11.80 213 782150 19735 109787201
Left atrial dilatation 15.80 11.80 3 782360 3557 109803379
Overgrowth bacterial 15.75 11.80 14 782349 257 109806679
Vascular pseudoaneurysm 15.74 11.80 5 782358 4185 109802751
Myelopathy 15.72 11.80 10 782353 5566 109801370
Periumbilical abscess 15.71 11.80 15 782348 303 109806633
Thyroiditis 15.70 11.80 14 782349 6559 109800377
Diabetes insipidus 15.68 11.80 14 782349 6556 109800380
Blood blister 15.62 11.80 4 782359 3855 109803081
Hepatic steatosis 15.60 11.80 247 782116 48584 109758352
JC virus infection 15.60 11.80 9 782354 5281 109801655
Aortic valve incompetence 15.59 11.80 34 782329 10947 109795989
Hepatitis E 15.59 11.80 6 782357 4453 109802483
Dilatation atrial 15.58 11.80 4 782359 3848 109803088
Vascular stent thrombosis 15.57 11.80 5 782358 4156 109802780
Breast cancer metastatic 15.56 11.80 35 782328 11146 109795790
Urine ketone body present 15.54 11.80 4 782359 3842 109803094
Muscle contractions involuntary 15.50 11.80 6 782357 4438 109802498
Exploratory operation 15.46 11.80 5 782358 7 109806929
Obstruction 15.45 11.80 81 782282 5671 109801265
Eye symptom 15.45 11.80 12 782351 181 109806755
Chlamydial infection 15.44 11.80 21 782342 631 109806305
Angle closure glaucoma 15.42 11.80 3 782360 3496 109803440
Suicidal behaviour 15.41 11.80 3 782360 3494 109803442
Blood magnesium increased 15.40 11.80 4 782359 3819 109803117
Device defective 15.40 11.80 4 782359 3818 109803118
Quadriparesis 15.38 11.80 7 782356 4700 109802236
Pancreatitis necrotising 15.33 11.80 10 782353 5491 109801445
Mass 15.31 11.80 209 782154 19421 109787515
Intra-abdominal haematoma 15.26 11.80 3 782360 3469 109803467
Crohn's disease 15.24 11.80 40 782323 1998 109804938
Tongue neoplasm malignant stage unspecified 15.23 11.80 31 782332 1308 109805628
Cytomegalovirus gastrointestinal infection 15.19 11.80 22 782341 702 109806234
Ejection fraction abnormal 15.18 11.80 3 782360 3457 109803479
Nerve block 15.15 11.80 23 782340 766 109806170
Surgery 15.14 11.80 391 781972 40892 109766044
Skin swelling 15.13 11.80 21 782342 8059 109798877
Staphylococcal skin infection 15.13 11.80 38 782325 1847 109805089
Mean cell volume decreased 15.12 11.80 80 782283 5622 109801314
Post procedural inflammation 15.11 11.80 13 782350 228 109806708
Cutaneous lymphoma 15.10 11.80 14 782349 272 109806664
International normalised ratio fluctuation 15.10 11.80 5 782358 4075 109802861
Enterocolitis infectious 15.08 11.80 3 782360 3441 109803495
Paralysis 15.05 11.80 58 782305 15542 109791394
Bacterial vulvovaginitis 15.05 11.80 21 782342 647 109806289
Escherichia urinary tract infection 15.01 11.80 61 782302 16101 109790835
White blood cell count abnormal 15.01 11.80 16 782347 6893 109800043
Pelvic abscess 14.99 11.80 47 782316 2599 109804337
Paranasal sinus hypersecretion 14.98 11.80 7 782356 4627 109802309
Acrochordon 14.97 11.80 32 782331 1398 109805538
Nasal discomfort 14.96 11.80 13 782350 6168 109800768
Salpingo-oophorectomy 14.95 11.80 7 782356 38 109806898
Anaphylactoid reaction 14.95 11.80 91 782272 6735 109800201
Salmonella sepsis 14.94 11.80 17 782346 424 109806512
Periorbital oedema 14.94 11.80 31 782332 10161 109796775
Electrocardiogram T wave inversion 14.93 11.80 11 782352 5669 109801267
Skin hyperpigmentation 14.93 11.80 24 782339 8672 109798264
Graft versus host disease in skin 14.92 11.80 22 782341 8232 109798704
Systemic candida 14.90 11.80 30 782333 9944 109796992
Septic pulmonary embolism 14.90 11.80 15 782348 324 109806612
Hypophysitis 14.88 11.80 10 782353 5405 109801531
Cytomegalovirus infection 14.87 11.80 497 781866 53947 109752989
Bone tuberculosis 14.87 11.80 22 782341 716 109806220
Stoma site abscess 14.86 11.80 15 782348 325 109806611
Gastrointestinal infection 14.82 11.80 158 782205 13847 109793089
Renal neoplasm 14.81 11.80 44 782319 2362 109804574
Product substitution 14.78 11.80 11 782352 155 109806781
Humerus fracture 14.78 11.80 34 782329 10742 109796194
Klebsiella bacteraemia 14.77 11.80 8 782355 4861 109802075
Metastases to meninges 14.73 11.80 9 782354 5119 109801817
Foreign body in eye 14.71 11.80 16 782347 379 109806557
Cerebral disorder 14.62 11.80 16 782347 6810 109800126
Mean cell haemoglobin increased 14.61 11.80 11 782352 5606 109801330
Pharyngitis bacterial 14.53 11.80 14 782349 286 109806650
Platelet disorder 14.51 11.80 4 782359 3671 109803265
Intracardiac thrombus 14.50 11.80 6 782357 4262 109802674
Joint lock 14.50 11.80 57 782306 3531 109803405
Cardiac tamponade 14.47 11.80 37 782326 11270 109795666
Loss of employment 14.46 11.80 3 782360 3341 109803595
Neck mass 14.44 11.80 70 782293 4751 109802185
Rhinitis 14.44 11.80 232 782131 22313 109784623
Neck pain 14.38 11.80 1034 781329 122096 109684840
Hair texture abnormal 14.36 11.80 5 782358 3949 109802987
Dyspnoea at rest 14.36 11.80 23 782340 8323 109798613
Glucose tolerance impaired 14.35 11.80 30 782333 9807 109797129
Lip blister 14.35 11.80 3 782360 3322 109803614
Increased bronchial secretion 14.33 11.80 5 782358 3943 109802993
Shoulder arthroplasty 14.33 11.80 57 782306 3550 109803386
Listless 14.32 11.80 7 782356 4508 109802428
Sarcoidosis 14.30 11.80 144 782219 12435 109794501
Accident at work 14.29 11.80 29 782334 1221 109805715
Impulsive behaviour 14.28 11.80 3 782360 3312 109803624
Autoimmune hepatitis 14.28 11.80 164 782199 14640 109792296
Enterococcal sepsis 14.27 11.80 3 782360 3309 109803627
Phototherapy 14.26 11.80 6 782357 24 109806912
Hypokinesia 14.26 11.80 93 782270 21733 109785203
Bacterial vaginosis 14.25 11.80 31 782332 1371 109805565
Mechanical ventilation 14.23 11.80 3 782360 3304 109803632
Tonsillectomy 14.21 11.80 23 782340 810 109806126
Heart rate increased 14.19 11.80 1192 781171 142642 109664294
Campylobacter infection 14.17 11.80 43 782320 2336 109804600
Scoliosis 14.16 11.80 25 782338 8708 109798228
Large intestine anastomosis 14.12 11.80 9 782354 97 109806839
Hyperpyrexia 14.11 11.80 22 782341 8047 109798889
Benign neoplasm 14.10 11.80 28 782335 1160 109805776
Drain site complication 14.07 11.80 6 782357 25 109806911
Peptic ulcer 14.07 11.80 20 782343 7599 109799337
Tearfulness 14.07 11.80 19 782344 7376 109799560
Pallor 14.06 11.80 510 781853 55957 109750979
Emphysema 14.04 11.80 82 782281 19674 109787262
Cerebellar haemorrhage 14.01 11.80 3 782360 3268 109803668
Stoma complication 13.98 11.80 26 782337 1025 109805911
Atypical femur fracture 13.97 11.80 14 782349 6205 109800731
Palmoplantar pustulosis 13.89 11.80 25 782338 961 109805975
Paraplegia 13.88 11.80 14 782349 6186 109800750
Foot operation 13.87 11.80 94 782269 7219 109799717
Gastrointestinal obstruction 13.82 11.80 41 782322 2199 109804737
Ingrown hair 13.78 11.80 22 782341 766 109806170
Pneumonia bacterial 13.78 11.80 119 782244 26142 109780794
Diabetic eye disease 13.74 11.80 12 782351 215 109806721
Gingival graft 13.74 11.80 9 782354 102 109806834
Bronchial hyperreactivity 13.73 11.80 4 782359 3540 109803396
Intercepted product prescribing error 13.72 11.80 16 782347 410 109806526
Dermatitis acneiform 13.72 11.80 45 782318 12650 109794286
Apraxia 13.71 11.80 4 782359 3536 109803400
Quadriplegia 13.70 11.80 6 782357 4121 109802815
Visceral leishmaniasis 13.68 11.80 35 782328 1721 109805215
Oesophageal fibrosis 13.67 11.80 11 782352 175 109806761
Pseudomembranous colitis 13.66 11.80 15 782348 6376 109800560
Skin induration 13.66 11.80 7 782356 4388 109802548
Nasal crusting 13.65 11.80 23 782340 838 109806098
Endodontic procedure 13.64 11.80 51 782312 3085 109803851
Hypopituitarism 13.63 11.80 7 782356 4383 109802553
Nephritis bacterial 13.62 11.80 7 782356 48 109806888
Clinically isolated syndrome 13.62 11.80 7 782356 48 109806888
Otitis externa bacterial 13.62 11.80 4 782359 3 109806933
Gliomatosis cerebri 13.62 11.80 4 782359 3 109806933
Anal neoplasm 13.62 11.80 4 782359 3 109806933
Neutrophil percentage increased 13.60 11.80 9 782354 4904 109802032
Ischaemic hepatitis 13.58 11.80 8 782355 4640 109802296
Poor quality product administered 13.54 11.80 8 782355 4633 109802303
Chronic granulomatous disease 13.50 11.80 7 782356 49 109806887
Serum ferritin increased 13.50 11.80 41 782322 11806 109795130
Product use complaint 13.49 11.80 5 782358 3798 109803138
Urethral polyp 13.48 11.80 8 782355 75 109806861
Hypoperfusion 13.46 11.80 3 782360 3178 109803758
Haemoperitoneum 13.45 11.80 11 782352 5377 109801559
Nasopharyngeal cancer 13.42 11.80 11 782352 180 109806756
Small intestinal haemorrhage 13.41 11.80 8 782355 4610 109802326
Tonsil cancer 13.41 11.80 29 782334 1277 109805659
Double stranded DNA antibody positive 13.41 11.80 18 782345 534 109806402
Polychondritis 13.40 11.80 24 782339 919 109806017
Lewis-Sumner syndrome 13.39 11.80 8 782355 76 109806860
Regurgitation 13.38 11.80 4 782359 3481 109803455
Scratch 13.35 11.80 47 782316 12932 109794004
Nervousness 13.30 11.80 182 782181 36669 109770267
Pneumocystis jirovecii infection 13.26 11.80 64 782299 4336 109802600
Cardiac pacemaker insertion 13.24 11.80 15 782348 6286 109800650
Odynophagia 13.24 11.80 53 782310 14048 109792888
Renal cell carcinoma 13.23 11.80 95 782268 7435 109799501
Signet-ring cell carcinoma 13.22 11.80 8 782355 78 109806858
Cervix carcinoma stage 0 13.17 11.80 13 782350 274 109806662
Slow speech 13.16 11.80 4 782359 3444 109803492
Deafness 13.15 11.80 123 782240 26586 109780350
Dental operation 13.13 11.80 31 782332 1448 109805488
Pleuritic pain 13.13 11.80 64 782299 16076 109790860
Depression suicidal 13.13 11.80 9 782354 4815 109802121
Epstein-Barr virus test positive 13.11 11.80 29 782334 1297 109805639
Metastasis 13.11 11.80 24 782339 8243 109798693
Panic attack 13.11 11.80 136 782227 28804 109778132
Linitis plastica 13.09 11.80 4 782359 4 109806932
Endometrial neoplasm 13.09 11.80 4 782359 4 109806932
Thyroid cancer 13.08 11.80 82 782281 6132 109800804
Discharge 13.08 11.80 40 782323 2182 109804754
Ear infection staphylococcal 13.05 11.80 6 782357 31 109806905
Enteropathy-associated T-cell lymphoma 13.05 11.80 6 782357 31 109806905
Ileocolectomy 13.05 11.80 8 782355 80 109806856
Bone density decreased 13.01 11.80 172 782191 15870 109791066
Infusion site pain 13.00 11.80 184 782179 17235 109789701
Asphyxia 12.99 11.80 54 782309 14161 109792775
Small intestine adenocarcinoma 12.95 11.80 12 782351 233 109806703
Normocytic anaemia 12.94 11.80 16 782347 6451 109800485
Female genital tract fistula 12.93 11.80 176 782187 16343 109790593
Pharyngeal neoplasm 12.90 11.80 6 782357 32 109806904
Injection site discomfort 12.89 11.80 18 782345 6889 109800047
Tonsillitis bacterial 12.87 11.80 12 782351 235 109806701
Vaginal ulceration 12.87 11.80 13 782350 282 109806654
Breast abscess 12.84 11.80 34 782329 1707 109805229
Diffuse large B-cell lymphoma stage II 12.83 11.80 9 782354 115 109806821
Cutaneous tuberculosis 12.79 11.80 13 782350 284 109806652
Endophthalmitis 12.78 11.80 24 782339 8163 109798773
Swollen joint count 12.77 11.80 105 782258 8569 109798367
Henoch-Schonlein purpura nephritis 12.75 11.80 6 782357 33 109806903
Cortical dysplasia 12.75 11.80 6 782357 33 109806903
Food poisoning 12.75 11.80 83 782280 6289 109800647
Affective disorder 12.74 11.80 39 782324 11202 109795734
Ear neoplasm 12.74 11.80 11 782352 194 109806742
Urostomy 12.73 11.80 5 782358 16 109806920
Oesophageal spasm 12.71 11.80 5 782358 3661 109803275
Bowen's disease 12.70 11.80 9 782354 117 109806819
Vulval disorder 12.67 11.80 23 782340 890 109806046
Beta haemolytic streptococcal infection 12.66 11.80 48 782315 2923 109804013
Intestinal dilatation 12.65 11.80 55 782308 3565 109803371
Acute abdomen 12.65 11.80 4 782359 3357 109803579
HIV test positive 12.65 11.80 10 782353 155 109806781
Duodenitis 12.63 11.80 29 782334 9167 109797769
Aspergillus infection 12.60 11.80 118 782245 25498 109781438
Haemorrhagic transformation stroke 12.58 11.80 3 782360 3034 109803902
Dysplasia 12.54 11.80 35 782328 1813 109805123
Tonsillar neoplasm 12.50 11.80 5 782358 17 109806919
Cyclic neutropenia 12.50 11.80 5 782358 17 109806919
Biliary dilatation 12.47 11.80 5 782358 3620 109803316
Rectal fissure 12.44 11.80 26 782337 1118 109805818
Human herpesvirus 6 infection 12.43 11.80 17 782346 6564 109800372
Seasonal allergy 12.40 11.80 85 782278 19637 109787299
Aortic dissection 12.40 11.80 10 782353 4923 109802013
Complications of bone marrow transplant 12.38 11.80 19 782344 639 109806297
Diabetic metabolic decompensation 12.38 11.80 6 782357 3883 109803053
Injection site irritation 12.36 11.80 10 782353 4914 109802022
Cystitis 12.35 11.80 364 781999 65672 109741264
Histone antibody positive 12.33 11.80 10 782353 161 109806775
Red blood cell count increased 12.33 11.80 10 782353 4908 109802028
Seroma 12.30 11.80 4 782359 3297 109803639
Optic neuropathy 12.27 11.80 9 782354 4649 109802287
Accident 12.27 11.80 125 782238 10827 109796109
Rash erythematous 12.26 11.80 464 781899 81368 109725568
Fungaemia 12.24 11.80 15 782348 6071 109800865
Unevaluable specimen 12.21 11.80 4 782359 6 109806930
Injury associated with device 12.20 11.80 8 782355 4381 109802555
Microangiopathy 12.18 11.80 3 782360 2969 109803967
Melanocytic naevus 12.15 11.80 75 782288 5579 109801357
Eyelid oedema 12.14 11.80 61 782302 15201 109791735
Anticoagulation drug level above therapeutic 12.13 11.80 9 782354 4621 109802315
Tonic clonic movements 12.06 11.80 3 782360 2949 109803987
Restrictive pulmonary disease 12.05 11.80 4 782359 3255 109803681
Type 1 diabetes mellitus 12.05 11.80 29 782334 9018 109797918
Immune-mediated hepatitis 12.02 11.80 18 782345 6693 109800243
Laryngeal disorder 11.99 11.80 26 782337 1147 109805789
Vesical fistula 11.98 11.80 11 782352 211 109806725
Product distribution issue 11.98 11.80 8 782355 4338 109802598
Viral pericarditis 11.97 11.80 8 782355 94 109806842
Hepatorenal syndrome 11.96 11.80 9 782354 4588 109802348
Salpingo-oophorectomy bilateral 11.95 11.80 13 782350 308 109806628
Rectal cancer metastatic 11.94 11.80 17 782346 534 109806402
Bone density abnormal 11.93 11.80 57 782306 3846 109803090
Epigastric discomfort 11.92 11.80 29 782334 8986 109797950
Throat clearing 11.91 11.80 8 782355 4325 109802611
Hepatic cirrhosis 11.90 11.80 589 781774 67037 109739899
Mononucleosis syndrome 11.90 11.80 11 782352 213 109806723
Antineutrophil cytoplasmic antibody positive 11.90 11.80 11 782352 5065 109801871
Skin fissures 11.89 11.80 113 782250 24345 109782591
Prostate ablation 11.88 11.80 3 782360 0 109806936
Unhealthy diet 11.88 11.80 3 782360 0 109806936
Foreign body in skin or subcutaneous tissue 11.88 11.80 3 782360 0 109806936
Rectal injury 11.88 11.80 3 782360 0 109806936
Pilonidal sinus repair 11.88 11.80 3 782360 0 109806936
Muscle disorder 11.85 11.80 18 782345 6654 109800282
Inflammation of lacrimal passage 11.84 11.80 4 782359 7 109806929
Walking aid user 11.83 11.80 246 782117 24829 109782107
Product supply issue 11.81 11.80 6 782357 3780 109803156
Product container issue 11.80 11.80 31 782332 1549 109805387

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AB02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Tumor necrosis factor alpha (TNF-alpha) inhibitors
FDA MoA N0000175451 Tumor Necrosis Factor Receptor Blocking Activity
MeSH PA D000079424 Tumor Necrosis Factor Inhibitors
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018501 Antirheumatic Agents
FDA EPC N0000175610 Tumor Necrosis Factor Blocker
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:39456 antiglaucoma drug
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent

Related Drugs by ATC class:

L04AB Tumor necrosis factor alpha (TNF-alpha) inhibitors 4 drugs
adalimumabcertolizumab pegoletanerceptgolimumab

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Ulcerative colitis indication 64766004 DOID:8577
Rheumatoid arthritis indication 69896004 DOID:7148
Plaque psoriasis indication 200965009
Pustular psoriasis indication 200973000
Erythrodermic psoriasis indication 200977004
Behcet's disease indication 310701003 DOID:13241
Adenosine deaminase deficiency 2 off-label use 987840791000119102




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Tumor necrosis factor Cytokine ANTIBODY BINDING UNKNOWN DRUG LABEL

External reference:

IDSource
D02598 KEGG_DRUG
4021126 VUID
N0000148580 NUI
4021126 VANDF
4036143 VANDF
CHEBI:749571 CHEBI
CHEMBL1201581 ChEMBL_ID
5004 IUPHAR_LIGAND_ID
DB00065 DRUGBANK_ID
1790539 RXNORM
11846 MMSL
230325 MMSL
33395 MMSL
33397 MMSL
353325 MMSL
7489 MMSL
d04342 MMSL
007640 NDDF
016773 NDDF
017837 NDDF
108675009 SNOMEDCT_US
386891004 SNOMEDCT_US
C0666743 UMLSCUI
D000069285 MESH_DESCRIPTOR_UI
7602 INN_ID
B72HH48FLU UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Renflexis HUMAN PRESCRIPTION DRUG LABEL 1 0006-4305 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 29 sections
INFLECTRA HUMAN PRESCRIPTION DRUG LABEL 1 0069-0809 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 32 sections
AVSOLA HUMAN PRESCRIPTION DRUG LABEL 1 55513-670 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 32 sections
REMICADE HUMAN PRESCRIPTION DRUG LABEL 1 57894-030 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 31 sections
INFLIXIMAB HUMAN PRESCRIPTION DRUG LABEL 1 57894-160 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 32 sections
ZYMFENTRA HUMAN PRESCRIPTION DRUG LABEL 1 72606-047 INJECTION 120 mg SUBCUTANEOUS BLA 29 sections
Renflexis HUMAN PRESCRIPTION DRUG LABEL 1 78206-162 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 32 sections