infliximab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
chimeric origin 4974 170277-31-3

Description:

MoleculeDescription

Synonyms:

  • INFLIXIMAB-QBTX
  • inflectra
  • infliximab
  • remicade
  • infliximab-dyyb
Infliximab products neutralize the biological activity of TNF-alpha by binding with high affinity to the soluble and transmembrane forms of TNF-alpha and inhibit binding of TNF-alpha with its receptors. Infliximab products do not neutralize TNF-beta (lymphotoxin-alpha), a related cytokine that utilizes the same receptors as TNF-alpha. Biological activities attributed to TNF-alpha include: induction of pro-inflammatory cytokines such as interleukins (IL) 1 and 6, enhancement of leukocyte migration by increasing endothelial layer permeability and expression of adhesion molecules by endothelial cells and leukocytes, activation of neutrophil and eosinophil functional activity, induction of acute phase reactants and other liver proteins, as well as tissue degrading enzymes produced by synoviocytes and/or chondrocytes. Cells expressing transmembrane TNF-alpha bound by infliximab products can be lysed in vitro or in vivo. Infliximab products inhibit the functional activity of TNF-alpha in a wide variety of in vitro bioassays utilizing human fibroblasts, endothelial cells, neutrophils, B and T-lymphocytes and epithelial cells. The relationship of these biological response markers to the mechanism(s) by which infliximab products exert their clinical effects is unknown. Anti-TNF-alpha antibodies reduce disease activity in the cotton-top tamarin colitis model, and decrease synovitis and joint erosions in a murine model of collagen-induced arthritis. Infliximab products prevent disease in transgenic mice that develop polyarthritis as a result of constitutive expression of human TNF-alpha, and when administered after disease onset, allow eroded joints to heal.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3.75 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 24, 1998 FDA CENTOCOR INC
Aug. 13, 1999 EMA
Jan. 17, 2002 PMDA Tanabe Seiyaku

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Infusion related reaction 5938.96 11.42 6672 356545 162885 50079022
Drug ineffective 3387.50 11.42 13150 350067 806183 49435724
Product use issue 3356.45 11.42 4715 358502 144760 50097147
Off label use 2616.41 11.42 8391 354826 466035 49775872
Systemic lupus erythematosus 2106.30 11.42 3685 359532 136937 50104970
Lupus-like syndrome 2071.41 11.42 1115 362102 8376 50233531
Contraindicated product administered 1937.33 11.42 3672 359545 145286 50096621
Drug intolerance 1826.12 11.42 4510 358707 214594 50027313
Treatment failure 1691.23 11.42 3313 359904 134324 50107583
Pemphigus 1614.71 11.42 3005 360212 117161 50124746
Alopecia 1406.82 11.42 4404 358813 240643 50001264
Intentional product use issue 1391.84 11.42 2196 361021 74722 50167185
Condition aggravated 1358.13 11.42 4945 358272 292113 49949794
Synovitis 1338.76 11.42 2828 360389 121037 50120870
Arthropathy 1308.03 11.42 3245 359972 154661 50087246
Glossodynia 1249.24 11.42 2639 360578 112930 50128977
Toxicity to various agents 1239.35 11.42 71 363146 212428 50029479
Hand deformity 1124.64 11.42 2324 360893 97875 50144032
Death 1052.50 11.42 511 362706 324868 49917039
Therapeutic product effect decreased 1027.62 11.42 2701 360516 133349 50108558
Acute kidney injury 938.80 11.42 240 362977 227818 50014089
Abdominal discomfort 933.01 11.42 3706 359511 227935 50013972
Drug interaction 877.40 11.42 182 363035 199439 50042468
Joint swelling 847.73 11.42 3745 359472 241541 50000366
Completed suicide 846.84 11.42 21 363196 131868 50110039
Wound 802.13 11.42 2104 361113 103690 50138217
Anti-cyclic citrullinated peptide antibody positive 797.21 11.42 1642 361575 68945 50172962
Inappropriate schedule of product administration 791.40 11.42 1654 361563 70177 50171730
Pericarditis 766.54 11.42 1724 361493 76965 50164942
Intestinal resection 707.91 11.42 344 362873 2023 50239884
Tuberculosis 687.37 11.42 574 362643 9509 50232398
Fall 660.14 11.42 863 362354 334069 49907838
Blood pressure fluctuation 658.74 11.42 1031 362186 34792 50207115
Skin cancer 642.92 11.42 536 362681 8858 50233049
Discomfort 623.68 11.42 1952 361265 106428 50135479
Hepatic enzyme increased 617.00 11.42 2277 360940 135103 50106804
Swelling 610.55 11.42 2955 360262 197917 50043990
Rheumatoid factor positive 608.33 11.42 1198 362019 48661 50193246
Transplant dysfunction 592.36 11.42 387 362830 4297 50237610
Maternal exposure during pregnancy 554.40 11.42 2444 360773 157334 50084573
Drug specific antibody present 546.43 11.42 326 362891 3042 50238865
Rheumatoid arthritis 546.10 11.42 2881 360336 199669 50042238
Basal cell carcinoma 544.81 11.42 752 362465 22604 50219303
Neutropenia 532.47 11.42 198 363019 147767 50094140
Anaemia 530.11 11.42 619 362598 251837 49990070
Febrile neutropenia 527.58 11.42 47 363170 97620 50144287
Breast cancer 515.28 11.42 1024 362193 41866 50200041
Drug level below therapeutic 502.50 11.42 321 362896 3419 50238488
Arthralgia 490.25 11.42 5052 358165 433650 49808257
Exposure during pregnancy 489.92 11.42 1941 361276 119074 50122833
Pulmonary tuberculosis 484.82 11.42 330 362887 3943 50237964
Fistula 471.49 11.42 424 362793 7794 50234113
Hyponatraemia 462.69 11.42 69 363148 96070 50145837
Disseminated tuberculosis 459.36 11.42 264 362953 2282 50239625
Asthenia 455.43 11.42 1010 362207 318032 49923875
Frequent bowel movements 454.59 11.42 530 362687 13388 50228519
Haematochezia 438.57 11.42 918 362299 38964 50202943
Hypersensitivity 433.17 11.42 2834 360383 212327 50029580
Hypotension 425.27 11.42 645 362572 234824 50007083
Product dose omission issue 424.42 11.42 416 362801 183422 50058485
Somnolence 417.55 11.42 302 362915 154683 50087224
White blood cell count decreased 402.06 11.42 167 363050 116555 50125352
Ovarian cyst 398.31 11.42 497 362720 13499 50228408
Helicobacter infection 390.14 11.42 1002 362215 48700 50193207
Drug abuse 389.92 11.42 8 363209 59838 50182069
Constipation 388.86 11.42 456 362761 185252 50056655
Duodenal ulcer perforation 387.87 11.42 948 362269 44663 50197244
Malignant neoplasm progression 386.97 11.42 26 363191 68098 50173809
Red blood cell sedimentation rate increased 383.39 11.42 727 362490 28689 50213218
Intentional overdose 382.91 11.42 15 363202 62489 50179418
Diarrhoea 382.75 11.42 2566 360651 585910 49655997
Injection site pain 382.16 11.42 159 363058 110865 50131042
Therapeutic product effect incomplete 378.43 11.42 1478 361739 90037 50151870
Psoriasis 371.36 11.42 1215 362002 67785 50174122
Transplant rejection 370.49 11.42 399 362818 9210 50232697
Platelet count decreased 370.39 11.42 130 363087 100596 50141311
Disease progression 364.23 11.42 117 363100 95749 50146158
Electrocardiogram QT prolonged 355.13 11.42 3 363214 51883 50190024
Cardiac arrest 341.87 11.42 89 363128 83562 50158345
Loss of personal independence in daily activities 336.96 11.42 1188 362029 68862 50173045
C-reactive protein abnormal 326.82 11.42 658 362559 27151 50214756
Overdose 321.03 11.42 157 363060 99570 50142337
Dizziness 320.96 11.42 1338 361879 345031 49896876
Insomnia 317.45 11.42 477 362740 174388 50067519
Seizure 314.39 11.42 232 362985 117642 50124265
Colectomy 309.14 11.42 191 363026 1909 50239998
Neuropathy peripheral 307.42 11.42 155 363062 96602 50145305
Flushing 302.30 11.42 1113 362104 65902 50176005
Injection site erythema 301.91 11.42 82 363135 74854 50167053
Intestinal stenosis 299.72 11.42 201 363016 2339 50239568
Acne 291.68 11.42 513 362704 19082 50222825
Thrombocytopenia 289.81 11.42 293 362924 127380 50114527
Hyperkalaemia 286.44 11.42 14 363203 48075 50193832
Oedema peripheral 285.62 11.42 432 362785 157529 50084378
Blood iron abnormal 279.28 11.42 214 363003 3112 50238795
Anal fistula 276.53 11.42 197 363020 2545 50239362
Pain 271.05 11.42 5733 357484 573170 49668737
Decreased appetite 268.66 11.42 658 362559 200265 50041642
Balance disorder 261.38 11.42 90 363127 70500 50171407
Sleep disorder due to general medical condition, insomnia type 256.10 11.42 643 362574 30804 50211103
Musculoskeletal stiffness 254.89 11.42 1687 361530 126794 50115113
Knee arthroplasty 252.20 11.42 694 362523 35152 50206755
Hypokalaemia 252.18 11.42 160 363057 87832 50154075
Cardiac failure 251.94 11.42 115 363102 75925 50165982
Bradycardia 251.20 11.42 75 363142 64351 50177556
Atrial fibrillation 249.09 11.42 218 362999 101527 50140380
Hypoglycaemia 247.53 11.42 43 363174 53538 50188369
Psoriatic arthropathy 247.45 11.42 822 362395 46210 50195697
Drug level decreased 246.13 11.42 268 362949 6265 50235642
Pancytopenia 244.68 11.42 150 363067 83880 50158027
Faecal calprotectin increased 243.46 11.42 166 363051 1989 50239918
Dehydration 238.76 11.42 457 362760 151992 50089915
Herpes zoster 237.69 11.42 1073 362144 69713 50172194
Coma 237.23 11.42 58 363159 56821 50185086
Agitation 235.61 11.42 48 363169 53336 50188571
Cardio-respiratory arrest 232.63 11.42 51 363166 53841 50188066
Hallucination 232.63 11.42 30 363187 46627 50195280
Blood glucose increased 228.43 11.42 113 363104 71211 50170696
Memory impairment 226.46 11.42 145 363072 79215 50162692
Therapeutic response shortened 224.15 11.42 271 362946 7118 50234789
Hip arthroplasty 221.93 11.42 597 362620 29832 50212075
Poor venous access 220.47 11.42 319 362898 10021 50231886
Anal abscess 220.24 11.42 197 363020 3594 50238313
Blood creatinine increased 217.53 11.42 139 363078 76021 50165886
Neutrophil count decreased 214.67 11.42 36 363181 45990 50195917
Gastrointestinal haemorrhage 213.31 11.42 131 363086 73190 50168717
Drug specific antibody 209.55 11.42 142 363075 1683 50240224
Suicide attempt 209.51 11.42 56 363161 51676 50190231
Cardiac failure congestive 205.08 11.42 182 363035 84200 50157707
Renal failure 203.12 11.42 281 362936 106352 50135555
Anxiety 202.73 11.42 628 362589 176978 50064929
Rheumatic fever 201.63 11.42 402 362815 16465 50225442
Rash 200.83 11.42 4322 358895 433149 49808758
International normalised ratio increased 198.52 11.42 35 363182 43117 50198790
Lymphoma 197.17 11.42 291 362926 9310 50232597
Epistaxis 196.38 11.42 107 363110 63847 50178060
Rhabdomyolysis 194.80 11.42 25 363192 39002 50202905
Gastrooesophageal reflux disease 194.11 11.42 158 363059 76270 50165637
Fluid retention 193.77 11.42 61 363156 50588 50191319
Uveitis 192.37 11.42 283 362934 9027 50232880
Histoplasmosis disseminated 191.93 11.42 118 363099 1168 50240739
Anal fissure 191.66 11.42 167 363050 2938 50238969
C-reactive protein increased 188.65 11.42 960 362257 65514 50176393
Sedation 188.64 11.42 7 363210 30603 50211304
Pyoderma gangrenosum 188.46 11.42 159 363058 2672 50239235
Haemoglobin decreased 186.63 11.42 396 362821 126820 50115087
Drug hypersensitivity 186.20 11.42 2678 360539 248332 49993575
Intentional product misuse 184.75 11.42 53 363164 46681 50195226
Hyperglycaemia 182.48 11.42 23 363194 36382 50205525
Blood parathyroid hormone decreased 180.99 11.42 239 362978 6875 50235032
Granuloma skin 180.77 11.42 216 363001 5602 50236305
Dyspnoea exertional 180.08 11.42 71 363146 51162 50190745
Panniculitis 179.36 11.42 261 362956 8242 50233665
Depressed level of consciousness 179.34 11.42 74 363143 51879 50190028
Product quality issue 177.52 11.42 11 363206 30847 50211060
Metabolic acidosis 177.49 11.42 32 363185 38793 50203114
Cognitive disorder 176.35 11.42 49 363168 44074 50197833
Colitis ulcerative 174.88 11.42 379 362838 16475 50225432
Arthritis 174.49 11.42 1143 362074 85578 50156329
Therapeutic response decreased 173.79 11.42 736 362481 46495 50195412
Mucosal inflammation 173.23 11.42 38 363179 40104 50201803
Infection 173.16 11.42 1951 361266 171003 50070904
Confusional state 172.60 11.42 717 362500 185211 50056696
Wrong technique in product usage process 168.79 11.42 94 363123 55416 50186491
Inflammation 167.89 11.42 831 362386 56081 50185826
Depression 167.55 11.42 616 362601 164807 50077100
Urinary tract infection 166.63 11.42 935 362282 223085 50018822
Nausea 166.18 11.42 3830 359387 701568 49540339
Neoplasm progression 165.93 11.42 11 363206 29146 50212761
Bone pain 165.09 11.42 66 363151 47163 50194744
Lactic acidosis 164.95 11.42 22 363195 33333 50208574
Demyelination 163.53 11.42 209 363008 5817 50236090
Injection site swelling 158.57 11.42 51 363166 41722 50200185
Tremor 156.83 11.42 372 362845 114531 50127376
Peritoneal tuberculosis 155.54 11.42 74 363143 412 50241495
Mucous stools 155.27 11.42 144 363073 2758 50239149
Swollen joint count increased 154.94 11.42 335 362882 14538 50227369
Muscle spasms 151.83 11.42 432 362785 125121 50116786
Blood bilirubin increased 151.78 11.42 24 363193 32014 50209893
Pulmonary embolism 151.32 11.42 314 362903 101390 50140517
Injection site pruritus 150.48 11.42 51 363166 40360 50201547
Pneumocystis jirovecii pneumonia 147.89 11.42 326 362891 14337 50227570
Red blood cell sedimentation rate abnormal 147.81 11.42 348 362869 15995 50225912
Bone erosion 146.29 11.42 284 362933 11403 50230504
Serum sickness 145.95 11.42 131 363086 2401 50239506
Pulmonary oedema 145.75 11.42 85 363132 48853 50193054
Full blood count decreased 145.49 11.42 3 363214 22343 50219564
Dysarthria 144.95 11.42 44 363173 37359 50204548
Rheumatoid nodule 144.46 11.42 297 362920 12438 50229469
Hypervolaemia 143.99 11.42 10 363207 25489 50216418
Adverse event 143.58 11.42 659 362558 43104 50198803
Polyarthritis 142.66 11.42 226 362991 7701 50234206
Ankylosing spondylitis 141.17 11.42 213 363004 6952 50234955
Hypoxia 140.98 11.42 97 363120 51026 50190881
Dry mouth 140.33 11.42 118 363099 56060 50185847
Dysgeusia 139.97 11.42 52 363165 38864 50203043
Drug reaction with eosinophilia and systemic symptoms 139.96 11.42 19 363198 28405 50213502
Feeling abnormal 139.42 11.42 449 362768 125043 50116864
Drug withdrawal syndrome 138.31 11.42 11 363206 25070 50216837
Folliculitis 137.96 11.42 603 362614 38622 50203285
Pulmonary hypertension 135.63 11.42 36 363181 33381 50208526
Vision blurred 135.47 11.42 222 362995 78425 50163482
Mental status changes 134.67 11.42 46 363171 36226 50205681
Ileostomy 134.14 11.42 90 363127 1048 50240859
Irritability 133.07 11.42 22 363195 28404 50213503
Cerebrovascular accident 132.83 11.42 302 362915 94378 50147529
Disorientation 131.75 11.42 45 363172 35439 50206468
Muscular weakness 131.73 11.42 305 362912 94708 50147199
Heart rate irregular 131.39 11.42 370 362847 18990 50222917
Intentional self-injury 130.69 11.42 9 363208 23103 50218804
Malignant melanoma 130.65 11.42 249 362968 9859 50232048
Histoplasmosis 130.06 11.42 105 363112 1654 50240253
Body temperature fluctuation 129.67 11.42 110 363107 1863 50240044
Pustular psoriasis 128.98 11.42 151 363066 3830 50238077
Sopor 128.12 11.42 3 363214 19876 50222031
Pneumonia legionella 127.39 11.42 93 363124 1251 50240656
Vascular access complication 127.13 11.42 87 363130 1049 50240858
Orthostatic hypotension 127.02 11.42 28 363189 29453 50212454
Musculoskeletal deformity 126.59 11.42 82 363135 896 50241011
Encephalopathy 126.47 11.42 42 363175 33669 50208238
Lethargy 125.74 11.42 102 363115 49330 50192577
Abscess 124.85 11.42 300 362917 13972 50227935
Injection site bruising 124.29 11.42 54 363163 36714 50205193
Full blood count abnormal 124.24 11.42 12 363205 23376 50218531
Unresponsive to stimuli 124.18 11.42 33 363184 30576 50211331
Clostridium difficile infection 123.57 11.42 433 362784 25006 50216901
Chest discomfort 121.57 11.42 1106 362111 91616 50150291
Drug tolerance decreased 120.07 11.42 227 362990 8933 50232974
Dysphagia 119.85 11.42 234 362983 77284 50164623
Therapy cessation 119.85 11.42 21 363196 25990 50215917
Therapy interrupted 119.57 11.42 6 363211 20146 50221761
Plasma cell myeloma 119.31 11.42 38 363179 31284 50210623
Palmar-plantar erythrodysaesthesia syndrome 119.20 11.42 6 363211 20092 50221815
Ileal stenosis 117.68 11.42 92 363125 1380 50240527
Hypomagnesaemia 117.60 11.42 14 363203 23142 50218765
B-cell lymphoma 116.91 11.42 125 363092 2860 50239047
Respiratory failure 116.76 11.42 305 362912 90876 50151031
Hodgkin's disease 116.24 11.42 72 363145 723 50241184
Tenosynovitis 115.86 11.42 243 362974 10322 50231585
Accidental overdose 115.32 11.42 6 363211 19527 50222380
Pulmonary arterial hypertension 114.64 11.42 8 363209 20311 50221596
Deep vein thrombosis 113.57 11.42 221 362996 73083 50168824
Disturbance in attention 113.29 11.42 41 363176 31145 50210762
Contrast media allergy 113.15 11.42 103 363114 1924 50239983
Urinary retention 112.58 11.42 25 363192 26165 50215742
Lymph node tuberculosis 111.89 11.42 69 363148 687 50241220
Suicidal ideation 111.51 11.42 140 363077 55245 50186662
Irritable bowel syndrome 110.20 11.42 689 362528 50752 50191155
Respiratory arrest 109.79 11.42 39 363178 29970 50211937
Joint destruction 109.71 11.42 138 363079 3778 50238129
Pouchitis 109.52 11.42 56 363161 373 50241534
Antinuclear antibody positive 109.01 11.42 176 363041 6096 50235811
Melaena 108.91 11.42 29 363188 26835 50215072
Delirium 108.62 11.42 70 363147 38122 50203785
Hypophagia 108.57 11.42 32 363185 27696 50214211
Toxic epidermal necrolysis 108.33 11.42 12 363205 20980 50220927
Enthesopathy 106.62 11.42 188 363029 7005 50234902
Blood calcium decreased 106.45 11.42 12 363205 20694 50221213
Pulmonary fibrosis 106.06 11.42 401 362816 24036 50217871
Pneumonia aspiration 105.65 11.42 45 363172 30959 50210948
Abdominal pain upper 105.20 11.42 690 362527 158619 50083288
Non-Hodgkin's lymphoma 105.17 11.42 84 363133 1302 50240605
Osteonecrosis of jaw 104.92 11.42 51 363166 32475 50209432
Pain in extremity 104.11 11.42 1357 361860 271508 49970399
Muscle injury 103.88 11.42 534 362683 36577 50205330
Cough 102.58 11.42 1172 362045 240092 50001815
Muscle spasticity 102.33 11.42 5 363212 17179 50224728
Throat tightness 102.26 11.42 356 362861 20491 50221416
Blood creatine phosphokinase increased 102.20 11.42 31 363186 26336 50215571
Withdrawal syndrome 101.99 11.42 6 363211 17584 50224323
Large intestinal stenosis 101.05 11.42 90 363127 1632 50240275
Asthma 101.05 11.42 317 362900 89020 50152887
Erythema nodosum 100.64 11.42 132 363085 3771 50238136
Hypothyroidism 100.58 11.42 60 363157 34065 50207842
Squamous cell carcinoma 100.47 11.42 191 363026 7548 50234359
Altered state of consciousness 100.27 11.42 18 363199 21892 50220015
Skin necrosis 100.02 11.42 233 362984 10634 50231273
Device issue 99.17 11.42 13 363204 19959 50221948
Lymphocyte count decreased 98.29 11.42 33 363184 26274 50215633
Device dislocation 97.96 11.42 18 363199 21528 50220379
Human antichimeric antibody positive 97.83 11.42 83 363134 1406 50240501
Blood alkaline phosphatase increased 97.24 11.42 76 363141 37450 50204457
Agranulocytosis 97.17 11.42 18 363199 21403 50220504
Drug level above therapeutic 97.11 11.42 130 363087 3790 50238117
Haematoma 96.66 11.42 49 363168 30461 50211446
Abortion spontaneous 96.12 11.42 570 362647 41202 50200705
Vomiting 96.00 11.42 2546 360671 458212 49783695
Dyskinesia 95.64 11.42 40 363177 27821 50214086
Blood potassium decreased 95.51 11.42 75 363142 36870 50205037
Aggression 95.23 11.42 18 363199 21098 50220809
Back pain 94.64 11.42 1066 362151 218964 50022943
Cervical dysplasia 94.19 11.42 108 363109 2677 50239230
Blood urea increased 92.74 11.42 27 363190 23558 50218349
Dry skin 92.47 11.42 104 363113 43087 50198820
Ascites 92.45 11.42 73 363144 35788 50206119
Neurotoxicity 92.12 11.42 3 363214 14737 50227170
Diarrhoea haemorrhagic 91.81 11.42 183 363034 7492 50234415
Lung neoplasm malignant 91.76 11.42 282 362935 15202 50226705
Nightmare 91.73 11.42 6 363211 16080 50225827
Acute respiratory failure 91.52 11.42 46 363171 28736 50213171
Type IV hypersensitivity reaction 88.62 11.42 99 363118 2383 50239524
Arthrodesis 88.52 11.42 99 363118 2386 50239521
Aphasia 88.44 11.42 47 363170 28447 50213460
Right ventricular failure 87.55 11.42 7 363210 15886 50226021
Hepatic function abnormal 87.48 11.42 64 363153 32617 50209290
Tuberculous pleurisy 87.15 11.42 47 363170 354 50241553
Hallucination, visual 86.80 11.42 9 363208 16573 50225334
Physical disability 86.21 11.42 85 363132 1762 50240145
Abnormal behaviour 86.05 11.42 18 363199 19640 50222267
Body height below normal 86.00 11.42 87 363130 1862 50240045
Thrombosis 85.90 11.42 169 363048 55664 50186243
Stevens-Johnson syndrome 85.35 11.42 25 363192 21727 50220180
Bronchitis chronic 84.68 11.42 121 363096 3756 50238151
Rash maculo-papular 84.08 11.42 43 363174 26598 50215309
Bone marrow failure 83.65 11.42 47 363170 27577 50214330
Disability 83.62 11.42 241 362976 12534 50229373
Cerebral haemorrhage 83.40 11.42 45 363172 27007 50214900
Upper gastrointestinal haemorrhage 83.17 11.42 9 363208 16026 50225881
Cardiac disorder 83.06 11.42 112 363105 42867 50199040
Injection site haemorrhage 82.91 11.42 25 363192 21321 50220586
Red blood cell sedimentation rate 82.90 11.42 115 363102 3471 50238436
Syncope 82.52 11.42 419 362798 102583 50139324
Renal impairment 82.40 11.42 273 362944 75388 50166519
Emotional distress 82.24 11.42 52 363165 28611 50213296
Multiple organ dysfunction syndrome 82.17 11.42 147 363070 50190 50191717
Pneumonia viral 81.81 11.42 163 363054 6671 50235236
Femur fracture 81.54 11.42 89 363128 37375 50204532
Neutropenic sepsis 81.50 11.42 5 363212 14142 50227765
Cervix carcinoma 81.41 11.42 96 363121 2454 50239453
Cholestasis 80.16 11.42 41 363176 25360 50216547
Urinary incontinence 79.81 11.42 52 363165 28156 50213751
Device malfunction 79.68 11.42 8 363209 15113 50226794
Heart rate decreased 78.25 11.42 489 362728 36008 50205899
Premature labour 77.55 11.42 219 362998 11257 50230650
Acute myocardial infarction 77.48 11.42 58 363159 29215 50212692
Listeriosis 77.32 11.42 70 363147 1298 50240609
Gastrointestinal disorder 77.24 11.42 1026 362191 93430 50148477
Infusion site reaction 77.07 11.42 87 363130 2119 50239788
Product administration error 76.64 11.42 23 363194 19676 50222231
Sleep apnoea syndrome 76.11 11.42 38 363179 23830 50218077
Hepatocellular injury 75.94 11.42 46 363171 25901 50216006
DNA antibody positive 75.66 11.42 40 363177 288 50241619
Chronic kidney disease 75.49 11.42 105 363112 39666 50202241
Antibody test positive 75.44 11.42 88 363129 2223 50239684
Hepatosplenic T-cell lymphoma 75.37 11.42 49 363168 539 50241368
Onychomycosis 73.73 11.42 131 363086 4911 50236996
Ill-defined disorder 73.68 11.42 656 362561 53998 50187909
Myalgia 73.45 11.42 556 362661 123763 50118144
Meningitis listeria 73.23 11.42 45 363172 445 50241462
Dermatitis psoriasiform 73.18 11.42 75 363142 1631 50240276
Diabetic ketoacidosis 73.01 11.42 19 363198 17853 50224054
Myoclonus 72.86 11.42 9 363208 14461 50227446
Generalised tonic-clonic seizure 72.42 11.42 50 363167 26260 50215647
Surgical failure 72.42 11.42 57 363160 864 50241043
Lymphoproliferative disorder 72.18 11.42 96 363121 2781 50239126
Mobility decreased 71.96 11.42 884 362333 79064 50162843
Headache 71.93 11.42 2940 360277 503595 49738312
Blood sodium decreased 71.56 11.42 31 363186 21116 50220791
Spinal column injury 71.53 11.42 76 363141 1726 50240181
Dry eye 71.23 11.42 75 363142 32020 50209887
Status epilepticus 70.89 11.42 7 363210 13399 50228508
Atypical mycobacterial infection 70.77 11.42 54 363163 780 50241127
Myocardial infarction 70.26 11.42 364 362853 88663 50153244
Bronchitis 69.80 11.42 449 362768 103710 50138197
Dysuria 69.80 11.42 61 363156 28443 50213464
Chronic obstructive pulmonary disease 69.72 11.42 177 363040 53258 50188649
Depressed mood 69.53 11.42 85 363132 33938 50207969
Haematemesis 69.52 11.42 58 363159 27667 50214240
Gamma-glutamyltransferase increased 69.44 11.42 66 363151 29557 50212350
Sinus bradycardia 69.40 11.42 7 363210 13176 50228731
Sciatica 69.39 11.42 321 362896 21061 50220846
Accidental exposure to product 68.71 11.42 40 363177 23017 50218890
Haemoptysis 68.55 11.42 50 363167 25523 50216384
Type 2 diabetes mellitus 68.43 11.42 452 362765 33923 50207984
Speech disorder 68.32 11.42 93 363124 35455 50206452
Hepatic failure 67.74 11.42 79 363138 32204 50209703
Psychotic disorder 67.66 11.42 36 363181 21776 50220131
Injection site mass 67.33 11.42 15 363202 15665 50226242
Respiratory depression 66.97 11.42 5 363212 12005 50229902
Anaphylactic reaction 66.90 11.42 637 362580 53418 50188489
Intestinal operation 66.67 11.42 41 363176 406 50241501
Circulatory collapse 66.60 11.42 30 363187 19970 50221937
Metastases to bone 66.49 11.42 23 363194 17972 50223935
Injection site rash 66.46 11.42 17 363200 16160 50225747
Contraindication to vaccination 65.82 11.42 34 363183 232 50241675
Arrhythmia 65.39 11.42 85 363132 33047 50208860
Female genital tract fistula 65.25 11.42 104 363113 3562 50238345
Pollakiuria 64.76 11.42 46 363171 23805 50218102
Hallucination, auditory 64.27 11.42 3 363214 10725 50231182
Blood potassium increased 64.06 11.42 19 363198 16379 50225528
Restlessness 63.94 11.42 52 363165 25121 50216786
Anal cancer 63.91 11.42 41 363176 440 50241467
Ulcer 63.89 11.42 301 362916 19899 50222008
Sinus tachycardia 63.70 11.42 37 363180 21317 50220590
Red blood cell count decreased 63.55 11.42 90 363127 33745 50208162
Skin exfoliation 63.53 11.42 89 363128 33523 50208384
Ejection fraction decreased 62.91 11.42 27 363190 18493 50223414
Tuberculin test positive 61.75 11.42 94 363123 3092 50238815
Red cell distribution width decreased 61.39 11.42 56 363161 1049 50240858
Colectomy total 61.07 11.42 27 363190 123 50241784
Nephrolithiasis 60.69 11.42 442 362775 34251 50207656
Dyspnoea 60.43 11.42 3265 359952 544343 49697564
Hyperlipidaemia 60.21 11.42 25 363192 17465 50224442
Extrapyramidal disorder 60.05 11.42 7 363210 11763 50230144
Wheelchair user 60.01 11.42 119 363098 4853 50237054
Mammoplasty 59.96 11.42 40 363177 461 50241446
Impaired healing 59.96 11.42 765 362452 69021 50172886
Hyperhidrosis 59.65 11.42 386 362831 89040 50152867
Vertigo 59.24 11.42 183 363034 51649 50190258
Amyotrophic lateral sclerosis 59.13 11.42 54 363163 1013 50240894
Anuria 59.12 11.42 6 363211 11238 50230669
Gastrointestinal inflammation 59.06 11.42 113 363104 4487 50237420
Salmonellosis 58.88 11.42 50 363167 848 50241059
Ventricular tachycardia 58.84 11.42 20 363197 15801 50226106
Subdural haematoma 58.46 11.42 11 363206 12936 50228971
Transient ischaemic attack 58.22 11.42 88 363129 32122 50209785
Renal disorder 58.04 11.42 67 363150 27438 50214469
Ileectomy 58.04 11.42 26 363191 123 50241784
Blood cholesterol increased 57.95 11.42 629 362588 54586 50187321
Grip strength decreased 57.73 11.42 205 363012 11916 50229991
Therapy non-responder 57.66 11.42 590 362627 50432 50191475
Mydriasis 57.66 11.42 5 363212 10622 50231285
Neoplasm malignant 57.40 11.42 328 362889 23387 50218520
Leukopenia 57.36 11.42 269 362948 67259 50174648
Delusion 57.27 11.42 5 363212 10564 50231343
Oedema 57.04 11.42 284 362933 69897 50172010
Pain in jaw 56.82 11.42 119 363098 38309 50203598
Electrolyte imbalance 56.79 11.42 26 363191 17143 50224764
Pleural effusion 56.70 11.42 347 362870 81107 50160800
Fear 56.58 11.42 17 363200 14532 50227375
Obstructive airways disorder 56.14 11.42 21 363196 15631 50226276
Eosinophilia 56.09 11.42 32 363185 18620 50223287
Pancreatitis acute 55.87 11.42 53 363164 23759 50218148
Sleep disorder 55.52 11.42 217 363000 57066 50184841
Blood glucose decreased 55.11 11.42 31 363186 18180 50223727
Jaundice 55.10 11.42 65 363152 26364 50215543
Sepsis 54.75 11.42 650 362567 132275 50109632
Nervousness 54.50 11.42 71 363146 27580 50214327
Haematuria 54.47 11.42 62 363155 25551 50216356
Injection site warmth 54.29 11.42 16 363201 13850 50228057
Epilepsy 54.22 11.42 45 363172 21522 50220385
Liver function test increased 54.22 11.42 342 362875 25264 50216643
Mycobacterium avium complex infection 53.85 11.42 78 363139 2452 50239455
Anal stenosis 53.68 11.42 32 363185 298 50241609
Proctectomy 53.38 11.42 19 363198 41 50241866
Muscle twitching 53.21 11.42 22 363195 15409 50226498
Acute hepatic failure 53.02 11.42 23 363194 15654 50226253
Coronary artery disease 52.97 11.42 82 363135 29644 50212263
Defaecation urgency 52.56 11.42 85 363132 2948 50238959
Vaginal fistula 52.52 11.42 34 363183 371 50241536
Coeliac disease 52.23 11.42 159 363058 8526 50233381
Leukocytosis 52.11 11.42 51 363166 22528 50219379
Ataxia 52.01 11.42 17 363200 13769 50228138
Urticaria 51.91 11.42 1257 361960 128304 50113603
Inappropriate antidiuretic hormone secretion 51.76 11.42 15 363202 13128 50228779
Unevaluable event 51.69 11.42 164 363053 45902 50196005
Drug level abnormal 51.66 11.42 21 363196 74 50241833
Head injury 51.24 11.42 58 363159 23962 50217945
Urine output decreased 51.22 11.42 7 363210 10414 50231493
Pneumonia 50.93 11.42 2209 361008 376192 49865715
Wheezing 50.47 11.42 251 362966 61796 50180111
Myelosuppression 50.42 11.42 17 363200 13500 50228407
Intestinal obstruction 50.16 11.42 343 362874 26040 50215867
Cytokine release syndrome 49.89 11.42 3 363214 8631 50233276
Ventricular fibrillation 49.81 11.42 8 363209 10551 50231356
Abdominal abscess 49.67 11.42 97 363120 3911 50237996
Sinus disorder 49.59 11.42 36 363181 18422 50223485
Cardiogenic shock 49.49 11.42 25 363192 15574 50226333
Mean platelet volume decreased 49.44 11.42 60 363157 1582 50240325
Dyspepsia 49.33 11.42 320 362897 73777 50168130
Cytomegalovirus infection 49.24 11.42 257 362960 17705 50224202
Hysterectomy 48.91 11.42 146 363071 7744 50234163
Listeria sepsis 48.77 11.42 38 363179 567 50241340
Infectious mononucleosis 48.74 11.42 60 363157 1606 50240301
Hypocalcaemia 48.72 11.42 73 363144 26743 50215164
Coagulopathy 48.21 11.42 35 363182 17909 50223998
Dystonia 48.10 11.42 13 363204 11913 50229994
Sensitivity to weather change 48.10 11.42 122 363095 5879 50236028
Hemiparesis 47.77 11.42 44 363173 20004 50221903
Mania 47.77 11.42 10 363207 10906 50231001
Productive cough 47.70 11.42 205 363012 52489 50189418
Peptic ulcer haemorrhage 47.37 11.42 47 363170 982 50240925
Cholangitis sclerosing 47.31 11.42 51 363166 1178 50240729
Adverse drug reaction 47.28 11.42 605 362612 54617 50187290
General physical health deterioration 47.25 11.42 1348 361869 141086 50100821
Haemorrhage intracranial 47.14 11.42 15 363202 12359 50229548
Rectal abscess 46.87 11.42 47 363170 995 50240912
Chromaturia 46.87 11.42 23 363194 14567 50227340
Lower respiratory tract infection 46.78 11.42 951 362266 94250 50147657
Ankle arthroplasty 46.74 11.42 49 363168 1095 50240812
Treatment noncompliance 46.59 11.42 91 363126 30059 50211848
Diabetes mellitus inadequate control 46.54 11.42 18 363199 13127 50228780
Small intestinal resection 46.34 11.42 31 363186 359 50241548
No adverse event 46.34 11.42 108 363109 33470 50208437
Psychomotor hyperactivity 46.31 11.42 6 363211 9295 50232612
Haematocrit decreased 46.29 11.42 115 363102 34861 50207046
Cerebral infarction 46.26 11.42 52 363165 21552 50220355
Cutaneous lupus erythematosus 46.10 11.42 71 363146 2360 50239547
Intestinal fistula 45.92 11.42 41 363176 746 50241161
Parkinsonism 45.80 11.42 5 363212 8842 50233065
Ankle operation 45.63 11.42 50 363167 1177 50240730
Acidosis 45.52 11.42 9 363208 10218 50231689
X-ray abnormal 45.52 11.42 74 363143 2578 50239329
Abdominal pain 45.47 11.42 2102 361115 234126 50007781
Injection site induration 45.42 11.42 4 363213 8393 50233514
Mental impairment 45.18 11.42 15 363202 12029 50229878
Lip ulceration 44.93 11.42 60 363157 1745 50240162
Tricuspid valve incompetence 44.37 11.42 18 363199 12752 50229155
Blood pressure diastolic abnormal 44.36 11.42 7 363210 9354 50232553
Affect lability 44.33 11.42 6 363211 8992 50232915
Neuralgia 44.27 11.42 55 363162 21808 50220099
Tinnitus 44.27 11.42 84 363133 28048 50213859
Blister 44.22 11.42 860 362357 84558 50157349
Tonsillar ulcer 44.19 11.42 27 363190 264 50241643
Subcutaneous abscess 44.19 11.42 104 363113 4778 50237129
Thirst 44.12 11.42 11 363206 10639 50231268
Cholecystitis chronic 44.12 11.42 8 363209 9661 50232246
Product use in unapproved indication 44.10 11.42 1116 362101 114703 50127204
Medication error 43.76 11.42 124 363093 35980 50205927
Brain oedema 43.69 11.42 17 363200 12353 50229554
Transfusion 43.53 11.42 19 363198 12886 50229021
Device breakage 43.35 11.42 8 363209 9539 50232368
Tubulointerstitial nephritis 43.08 11.42 28 363189 15183 50226724
T-cell lymphoma 43.01 11.42 36 363181 598 50241309
Deformity 42.83 11.42 140 363077 7800 50234107
Lymphoedema 42.83 11.42 7 363210 9115 50232792
Cutaneous T-cell lymphoma 42.72 11.42 49 363168 1215 50240692
Dialysis 42.66 11.42 8 363209 9430 50232477
Antinuclear antibody increased 42.52 11.42 48 363169 1169 50240738
Laboratory test abnormal 42.33 11.42 63 363154 23145 50218762
Abnormal dreams 42.27 11.42 8 363209 9369 50232538
Fine motor skill dysfunction 42.25 11.42 92 363125 4011 50237896
Rectal stenosis 42.24 11.42 22 363195 153 50241754
Obliterative bronchiolitis 42.20 11.42 59 363158 1794 50240113
Ischaemic stroke 41.69 11.42 32 363185 15916 50225991
Caesarean section 41.66 11.42 222 362995 15417 50226490
Meningitis tuberculous 41.61 11.42 33 363184 506 50241401
Wrist surgery 41.54 11.42 39 363178 759 50241148
Schizophrenia 41.48 11.42 3 363214 7394 50234513
Ear pain 41.46 11.42 88 363129 28195 50213712
Thinking abnormal 41.38 11.42 9 363208 9558 50232349
Device difficult to use 41.37 11.42 10 363207 9876 50232031
Exposure via father 41.04 11.42 25 363192 243 50241664
Gastritis 40.93 11.42 112 363105 32871 50209036
Hidradenitis 40.75 11.42 60 363157 1915 50239992
Needle issue 40.65 11.42 3 363214 7272 50234635
Cytopenia 40.61 11.42 7 363210 8768 50233139
Double stranded DNA antibody 40.55 11.42 20 363197 122 50241785
Tonsillitis 40.42 11.42 101 363116 4822 50237085
Paranoia 40.40 11.42 12 363205 10336 50231571
Paradoxical psoriasis 40.16 11.42 20 363197 125 50241782
Complication associated with device 40.14 11.42 28 363189 14627 50227280
Product prescribing error 40.11 11.42 55 363162 20906 50221001
Product complaint 40.10 11.42 16 363201 11450 50230457
Hypothermia 40.05 11.42 18 363199 11998 50229909
Vaginal haemorrhage 39.79 11.42 72 363145 24479 50217428
Malignant respiratory tract neoplasm 39.70 11.42 15 363202 41 50241866
Product substitution issue 39.65 11.42 26 363191 14031 50227876
Injection site urticaria 39.64 11.42 19 363198 12198 50229709
Left ventricular dysfunction 39.56 11.42 13 363204 10493 50231414
Proctitis 38.96 11.42 58 363159 1870 50240037
Restless legs syndrome 38.95 11.42 34 363183 15863 50226044
Pseudopolyp 38.91 11.42 24 363193 239 50241668
Tumour lysis syndrome 38.91 11.42 4 363213 7417 50234490
Prothrombin time prolonged 38.87 11.42 8 363209 8830 50233077
Serum ferritin decreased 38.72 11.42 53 363164 1579 50240328
Drug exposure before pregnancy 38.67 11.42 36 363181 693 50241214
Retinitis 38.46 11.42 57 363160 1830 50240077
Feeling jittery 38.34 11.42 16 363201 11144 50230763
Joint effusion 38.28 11.42 190 363027 12831 50229076
Pneumonia cryptococcal 38.24 11.42 34 363183 615 50241292
Skin ulcer 37.82 11.42 404 362813 34914 50206993
Hyperbilirubinaemia 37.54 11.42 11 363206 9559 50232348
Joint arthroplasty 37.48 11.42 60 363157 2063 50239844
Extrapulmonary tuberculosis 37.41 11.42 25 363192 289 50241618
Bone disorder 37.11 11.42 48 363169 18704 50223203
Dementia 37.07 11.42 36 363181 15961 50225946
Hypovolaemia 36.91 11.42 11 363206 9454 50232453
Mood altered 36.88 11.42 23 363194 12750 50229157
Cardiomegaly 36.82 11.42 36 363181 15909 50225998
Mean cell volume decreased 36.77 11.42 67 363150 2562 50239345
Liver disorder 36.75 11.42 419 362798 36803 50205104
Abdominal distension 36.72 11.42 340 362877 72563 50169344
Rectal haemorrhage 36.71 11.42 431 362786 38127 50203780
Blood loss anaemia 36.57 11.42 7 363210 8132 50233775
Glomerular filtration rate decreased 36.48 11.42 19 363198 11633 50230274
Incorrect dose administered 36.34 11.42 518 362699 47896 50194011
Hiatus hernia 36.26 11.42 47 363170 18297 50223610
Hepatic encephalopathy 36.15 11.42 12 363205 9624 50232283
Hip fracture 36.11 11.42 83 363134 25848 50216059
Ageusia 36.10 11.42 19 363198 11564 50230343
Cholelithiasis 36.07 11.42 145 363072 37828 50204079
Salivary hypersecretion 36.04 11.42 3 363214 6588 50235319
Smear cervix abnormal 36.01 11.42 68 363149 2673 50239234
Injection site discolouration 35.95 11.42 4 363213 6970 50234937
Blood lactate dehydrogenase increased 35.78 11.42 53 363164 19509 50222398
Osteonecrosis 35.63 11.42 67 363150 22450 50219457
Liver function test abnormal 35.55 11.42 480 362737 43859 50198048
Lower respiratory tract infection viral 35.50 11.42 33 363184 634 50241273
Renal injury 35.47 11.42 9 363208 8602 50233305
Tuberculosis gastrointestinal 35.35 11.42 25 363192 319 50241588
Suffocation feeling 35.33 11.42 44 363173 1192 50240715
Diffuse large B-cell lymphoma 35.31 11.42 105 363112 5557 50236350
Cardiac failure acute 35.20 11.42 8 363209 8242 50233665
Pyrexia 35.19 11.42 2304 360913 377899 49864008
Atrial flutter 34.51 11.42 10 363207 8753 50233154
Troponin increased 34.39 11.42 8 363209 8110 50233797
Enterostomy 34.07 11.42 19 363198 154 50241753
Burning sensation 34.07 11.42 189 363028 45257 50196650
Hypoacusis 33.95 11.42 60 363157 20587 50221320
Varicella 33.83 11.42 51 363166 1663 50240244
Haemodynamic instability 33.80 11.42 8 363209 8016 50233891
Mesenteritis 33.66 11.42 18 363199 133 50241774
Coccidioidomycosis 33.59 11.42 36 363181 826 50241081
Chronic recurrent multifocal osteomyelitis 33.53 11.42 13 363204 39 50241868
Diplopia 33.49 11.42 54 363163 19206 50222701
Faecal calprotectin abnormal 33.09 11.42 14 363203 56 50241851
Swelling face 33.07 11.42 231 362986 52364 50189543
Metastases to central nervous system 33.01 11.42 20 363197 11262 50230645
Haemorrhage 32.98 11.42 236 362981 53205 50188702
Atelectasis 32.93 11.42 50 363167 18220 50223687
Seasonal allergy 32.90 11.42 34 363183 14642 50227265
Petechiae 32.84 11.42 25 363192 12487 50229420
SAPHO syndrome 32.82 11.42 15 363202 75 50241832
Blood pressure abnormal 32.79 11.42 26 363191 12721 50229186
Hair follicle tumour benign 32.71 11.42 25 363192 362 50241545
Torus fracture 32.67 11.42 17 363200 118 50241789
Mental disorder 32.59 11.42 68 363149 21923 50219984
Fear of injection 32.37 11.42 107 363110 5996 50235911
Obstruction 32.36 11.42 56 363161 2055 50239852
Alanine aminotransferase increased 32.30 11.42 443 362774 87916 50153991
Respiratory acidosis 32.26 11.42 3 363214 6025 50235882
Pruritus allergic 32.22 11.42 40 363177 1080 50240827
Haemodialysis 32.10 11.42 10 363207 8352 50233555
Acute generalised exanthematous pustulosis 32.04 11.42 12 363205 8926 50232981
Enterocutaneous fistula 32.02 11.42 41 363176 1143 50240764
Night sweats 32.01 11.42 128 363089 33446 50208461
Shock haemorrhagic 31.99 11.42 10 363207 8334 50233573
Proctocolectomy 31.97 11.42 12 363205 32 50241875
Visual acuity reduced 31.80 11.42 60 363157 20079 50221828
Cardiac murmur 31.72 11.42 19 363198 10765 50231142
Rales 31.64 11.42 16 363201 9962 50231945
Colostomy 31.42 11.42 31 363186 643 50241264
Skin burning sensation 31.31 11.42 17 363200 10168 50231739
Device leakage 31.26 11.42 3 363214 5875 50236032
Upper respiratory tract infection 31.21 11.42 312 362905 65586 50176321
Soft tissue disorder 31.04 11.42 83 363134 4131 50237776
Incorrect drug administration rate 31.01 11.42 62 363155 2544 50239363
Flatulence 30.90 11.42 108 363109 29350 50212557
Musculoskeletal disorder 30.89 11.42 222 362995 17127 50224780
Colon cancer 30.84 11.42 134 363083 8557 50233350
Eye irritation 30.81 11.42 47 363170 17093 50224814
Anorectal disorder 30.78 11.42 45 363172 1427 50240480
Aspiration 30.68 11.42 14 363203 9250 50232657
Hypophosphataemia 30.66 11.42 11 363206 8403 50233504
Impaired gastric emptying 30.62 11.42 134 363083 8584 50233323
Henoch-Schonlein purpura 30.62 11.42 37 363180 971 50240936
Oligohydramnios 30.41 11.42 3 363214 5747 50236160
Taste disorder 30.13 11.42 11 363206 8313 50233594
Aplastic anaemia 29.95 11.42 9 363208 7694 50234213
Injection site haematoma 29.95 11.42 4 363213 6056 50235851
Lymphopenia 29.88 11.42 41 363176 15580 50226327
Activated partial thromboplastin time prolonged 29.86 11.42 5 363212 6397 50235510
Hepatitis acute 29.71 11.42 10 363207 7951 50233956
Device occlusion 29.71 11.42 4 363213 6019 50235888
Fracture 29.45 11.42 47 363170 16786 50225121
Small intestinal stenosis 29.26 11.42 26 363191 470 50241437
Opportunistic infection 29.04 11.42 47 363170 1631 50240276
Lung cancer metastatic 29 11.42 56 363161 2239 50239668
Subarachnoid haemorrhage 28.97 11.42 21 363196 10755 50231152
Toxic encephalopathy 28.85 11.42 3 363214 5512 50236395
Myelodysplastic syndrome 28.66 11.42 40 363177 15092 50226815
Drug eruption 28.61 11.42 277 362940 23329 50218578
Onychomadesis 28.46 11.42 72 363145 3464 50238443
Motor dysfunction 28.43 11.42 11 363206 8020 50233887
Supraventricular tachycardia 28.31 11.42 30 363187 12771 50229136
Mean cell haemoglobin decreased 28.15 11.42 69 363148 3254 50238653
Crohn's disease 27.86 11.42 86 363131 4647 50237260
Sudden death 27.65 11.42 15 363202 8976 50232931
Stress cardiomyopathy 27.59 11.42 11 363206 7876 50234031
Guttate psoriasis 27.38 11.42 22 363195 344 50241563
Nail disorder 27.37 11.42 140 363077 9568 50232339
Large intestinal ulcer 27.37 11.42 65 363152 3004 50238903
Lung neoplasm 27.34 11.42 93 363124 5289 50236618
Intestinal anastomosis 27.25 11.42 21 363196 308 50241599
Growth retardation 27.09 11.42 36 363181 1042 50240865
Respiratory tract infection 26.91 11.42 128 363089 31889 50210018
Small intestine carcinoma 26.86 11.42 22 363195 354 50241553
Eye pain 26.78 11.42 109 363108 28340 50213567
Eosinophil count increased 26.77 11.42 15 363202 8815 50233092
Aspartate aminotransferase increased 26.76 11.42 396 362821 77602 50164305
Swollen tongue 26.76 11.42 110 363107 28520 50213387
Urine abnormality 26.72 11.42 6 363211 6232 50235675
Ileostomy closure 26.69 11.42 14 363203 99 50241808
Arthritis enteropathic 26.58 11.42 18 363199 213 50241694
Tuberculosis liver 26.57 11.42 8 363209 7 50241900
Drug level increased 26.56 11.42 62 363155 19206 50222701
Limb operation 26.56 11.42 68 363149 3296 50238611
Thrombotic microangiopathy 26.55 11.42 15 363202 8776 50233131
Shoulder arthroplasty 26.50 11.42 69 363148 3379 50238528
Polyuria 26.48 11.42 9 363208 7112 50234795
Haemolytic anaemia 26.46 11.42 17 363200 9275 50232632
Neuroendocrine carcinoma of the skin 26.38 11.42 24 363193 448 50241459
Amnesia 26.38 11.42 186 363031 42074 50199833
Dysphonia 26.37 11.42 167 363050 38725 50203182
Macular degeneration 26.30 11.42 39 363178 14349 50227558
Metabolic encephalopathy 26.24 11.42 3 363214 5118 50236789
Disease susceptibility 26.07 11.42 17 363200 188 50241719
Pneumonitis 25.98 11.42 116 363101 29394 50212513
Neck deformity 25.90 11.42 49 363168 1929 50239978
Hypercalcaemia 25.88 11.42 269 362948 23083 50218824
Hypotonia 25.86 11.42 13 363204 8121 50233786
Stoma creation 25.74 11.42 9 363208 18 50241889
Sneezing 25.74 11.42 38 363179 14006 50227901
Neck mass 25.57 11.42 67 363150 3294 50238613
Anastomotic stenosis 25.36 11.42 18 363199 231 50241676
Muscle rigidity 25.34 11.42 20 363197 9809 50232098
Nephropathy toxic 25.27 11.42 13 363204 8016 50233891
Paraesthesia 25.27 11.42 663 362554 119580 50122327
Skin discolouration 25.23 11.42 135 363082 32622 50209285
Diabetic eye disease 25.22 11.42 15 363202 139 50241768
Bartholin's cyst 25.13 11.42 7 363210 3 50241904
Micturition urgency 25.10 11.42 14 363203 8250 50233657
Peripheral sensory neuropathy 25.09 11.42 8 363209 6583 50235324
Peripheral swelling 25.08 11.42 1758 361459 204178 50037729
Hypermobility syndrome 25.00 11.42 29 363188 728 50241179
Immune thrombocytopenia 25.00 11.42 17 363200 9000 50232907
Blood pressure systolic abnormal 24.98 11.42 12 363205 7694 50234213
Shock 24.97 11.42 71 363146 20579 50221328
Intestinal sepsis 24.91 11.42 18 363199 238 50241669
Intestinal tuberculosis 24.91 11.42 12 363205 69 50241838
Oliguria 24.84 11.42 14 363203 8202 50233705
Bundle branch block left 24.74 11.42 7 363210 6223 50235684
Granuloma 24.73 11.42 84 363133 4774 50237133
Adhesiolysis 24.71 11.42 8 363209 11 50241896
Exercise tolerance decreased 24.62 11.42 3 363214 4871 50237036
Fistula discharge 24.56 11.42 32 363185 908 50240999
Blood triglycerides increased 24.47 11.42 27 363190 11285 50230622
Duodenal ulcer 24.45 11.42 9 363208 6766 50235141
Secondary amyloidosis 24.24 11.42 9 363208 23 50241884
Angina pectoris 24.24 11.42 101 363116 26087 50215820
Nocturia 24.18 11.42 9 363208 6721 50235186
Apathy 24.09 11.42 12 363205 7536 50234371
Investigation abnormal 24.06 11.42 37 363180 1228 50240679
Sports injury 23.98 11.42 9 363208 24 50241883
Bowen's disease 23.90 11.42 17 363200 219 50241688
Oxygen saturation abnormal 23.85 11.42 57 363160 2645 50239262
Hypoaesthesia 23.85 11.42 713 362504 126544 50115363
Pneumocystis jirovecii infection 23.84 11.42 37 363180 1238 50240669
Gastrointestinal carcinoma 23.84 11.42 40 363177 1431 50240476
Lupus vasculitis 23.83 11.42 23 363194 464 50241443
Oxygen saturation decreased 23.73 11.42 376 362841 72872 50169035
Pulmonary congestion 23.57 11.42 46 363171 15201 50226706
Blood calcium increased 23.56 11.42 13 363204 7706 50234201
Infusion site erythema 23.47 11.42 17 363200 8710 50233197
Middle insomnia 23.37 11.42 22 363195 9899 50232008
Coordination abnormal 23.37 11.42 29 363188 11505 50230402
Pathological fracture 23.36 11.42 13 363204 7669 50234238
Tooth disorder 23.33 11.42 92 363125 24136 50217771
Genital haemorrhage 23.28 11.42 9 363208 6565 50235342
Osteopenia 23.27 11.42 55 363162 16963 50224944
Dysstasia 23.26 11.42 59 363158 17760 50224147
Brachiocephalic artery stenosis 23.21 11.42 9 363208 27 50241880
Papilloma viral infection 23.16 11.42 37 363180 1270 50240637
Incorrect dosage administered 23.12 11.42 43 363174 1671 50240236
Progressive multifocal leukoencephalopathy 23.01 11.42 29 363188 11428 50230479
Mycobacterium marinum infection 22.90 11.42 16 363201 200 50241707
Anaplastic large-cell lymphoma 22.86 11.42 12 363205 85 50241822
Ventricular extrasystoles 22.86 11.42 25 363192 10491 50231416
Concomitant disease aggravated 22.77 11.42 15 363202 8076 50233831
Ovarian cancer 22.76 11.42 85 363132 5064 50236843
Skin hyperpigmentation 22.75 11.42 5 363212 5271 50236636
Abscess intestinal 22.74 11.42 38 363179 1355 50240552
Mitral valve incompetence 22.68 11.42 58 363159 17413 50224494
Epstein-Barr virus infection 22.67 11.42 105 363112 6892 50235015
Clear cell renal cell carcinoma 22.62 11.42 35 363182 1168 50240739
Visual impairment 22.61 11.42 349 362868 67926 50173981
Poor quality sleep 22.60 11.42 54 363163 16592 50225315
Rib fracture 22.57 11.42 67 363150 19154 50222753
Nystagmus 22.55 11.42 6 363211 5555 50236352
Incorrect product administration duration 22.52 11.42 20 363197 9255 50232652
Lipase increased 22.50 11.42 17 363200 8524 50233383
Inflammatory bowel disease 22.49 11.42 65 363152 3385 50238522
Bradyphrenia 22.49 11.42 8 363209 6144 50235763
Application site erythema 22.42 11.42 3 363214 4535 50237372
Renal tubular necrosis 22.29 11.42 24 363193 10144 50231763
Metastases to liver 22.25 11.42 72 363145 20032 50221875
Amenorrhoea 22.21 11.42 17 363200 8467 50233440
Faecal volume decreased 22.16 11.42 14 363203 146 50241761
Faeces discoloured 22.14 11.42 52 363165 16072 50225835
Polyneuropathy 22.06 11.42 33 363184 12098 50229809
Decubitus ulcer 22.05 11.42 21 363196 9397 50232510
Thyroid cancer 22.03 11.42 73 363144 4096 50237811
Dental caries 21.96 11.42 23 363194 9844 50232063
Lower gastrointestinal haemorrhage 21.86 11.42 11 363206 6868 50235039
Pelvic abscess 21.85 11.42 38 363179 1400 50240507
Jaundice cholestatic 21.72 11.42 5 363212 5106 50236801
Respiratory syncytial virus infection 21.67 11.42 5 363212 5097 50236810
Proteinuria 21.62 11.42 55 363162 16542 50225365
Gastrointestinal scarring 21.62 11.42 16 363201 220 50241687
Cardiomyopathy 21.61 11.42 50 363167 15536 50226371
Spinal fracture 21.56 11.42 50 363167 15523 50226384
Rectal cancer 21.53 11.42 42 363175 1692 50240215
Lung adenocarcinoma 21.50 11.42 72 363145 4062 50237845
Mycobacterial infection 21.47 11.42 40 363177 1556 50240351
Product substitution 21.47 11.42 7 363210 10 50241897
Protein urine present 21.43 11.42 6 363211 5371 50236536
Anger 21.42 11.42 30 363187 11303 50230604
Heavy menstrual bleeding 21.41 11.42 50 363167 15487 50226420
Colostomy closure 21.37 11.42 13 363204 126 50241781
Acute pulmonary histoplasmosis 21.20 11.42 13 363204 128 50241779
Temperature intolerance 21.19 11.42 14 363203 7525 50234382
Glycosylated haemoglobin increased 21.14 11.42 27 363190 10579 50231328
Atrioventricular block 21.13 11.42 10 363207 6468 50235439
Cervix carcinoma stage 0 21.11 11.42 18 363199 307 50241600
Product physical issue 21.08 11.42 3 363214 4329 50237578
Epicondylitis 21.04 11.42 44 363173 1865 50240042
Atrioventricular block complete 21.04 11.42 13 363204 7242 50234665
Metastases to lung 21.00 11.42 29 363188 10991 50230916
Peritonitis bacterial 20.96 11.42 4 363213 4657 50237250
Ophthalmic herpes zoster 20.95 11.42 41 363176 1656 50240251
Neutrophil count increased 20.94 11.42 44 363173 14151 50227756
Hypertensive crisis 20.94 11.42 39 363178 13115 50228792
Apnoea 20.88 11.42 12 363205 6954 50234953
Emotional disorder 20.75 11.42 33 363184 11803 50230104
Weight increased 20.66 11.42 1700 361517 200191 50041716
Infusion site extravasation 20.65 11.42 102 363115 6874 50235033
Musculoskeletal chest pain 20.60 11.42 66 363151 18420 50223487
Joint tuberculosis 20.57 11.42 12 363205 107 50241800
Ankle deformity 20.54 11.42 20 363197 408 50241499
Legionella infection 20.54 11.42 20 363197 408 50241499
Device failure 20.54 11.42 7 363210 5521 50236386
Ammonia increased 20.49 11.42 3 363214 4238 50237669
Accident 20.38 11.42 82 363135 5059 50236848
Pericarditis tuberculous 20.35 11.42 7 363210 13 50241894
Gingival graft 20.35 11.42 7 363210 13 50241894
Blood creatine increased 20.34 11.42 5 363212 4882 50237025
Aplasia pure red cell 20.32 11.42 3 363214 4212 50237695
Eye movement disorder 20.23 11.42 4 363213 4541 50237366
Lupus hepatitis 20.16 11.42 8 363209 26 50241881
Hot flush 20.14 11.42 211 363006 43958 50197949
Carcinoma in situ of skin 20.11 11.42 15 363202 209 50241698
Loss of therapeutic response 20.10 11.42 14 363203 174 50241733
Clonus 20.06 11.42 3 363214 4172 50237735
Perirectal abscess 20.04 11.42 28 363189 851 50241056
Sigmoidectomy 20.02 11.42 7 363210 14 50241893
Cutaneous tuberculosis 19.92 11.42 13 363204 144 50241763
International normalised ratio decreased 19.89 11.42 3 363214 4145 50237762
Iritis 19.85 11.42 51 363166 2477 50239430
Gastrointestinal stenosis 19.84 11.42 14 363203 178 50241729
Mycobacterium chelonae infection 19.81 11.42 20 363197 427 50241480
Salpingectomy 19.77 11.42 14 363203 179 50241728
Hypoalbuminaemia 19.76 11.42 25 363192 9835 50232072
Substance abuse 19.73 11.42 3 363214 4121 50237786
Takayasu's arteritis 19.72 11.42 5 363212 0 50241907
Pulmonary haemorrhage 19.72 11.42 11 363206 6481 50235426
Blood magnesium decreased 19.68 11.42 31 363186 11129 50230778
Rheumatoid lung 19.64 11.42 50 363167 2415 50239492
Coma scale abnormal 19.63 11.42 5 363212 4766 50237141
Mouth ulceration 19.51 11.42 296 362921 27728 50214179
Fistula repair 19.51 11.42 8 363209 29 50241878
Therapeutic product effect variable 19.51 11.42 31 363186 1059 50240848
Eyelid ptosis 19.50 11.42 10 363207 6177 50235730
Chest pain 19.50 11.42 1054 362163 175828 50066079
Vaginal abscess 19.40 11.42 18 363199 345 50241562
Squamous cell carcinoma of lung 19.34 11.42 26 363191 761 50241146
Enzyme level increased 19.33 11.42 17 363200 303 50241604
Erythema 19.25 11.42 1258 361959 145156 50096751
Anaphylactoid reaction 19.23 11.42 61 363156 3345 50238562
Nasal congestion 19.15 11.42 255 362962 50865 50191042
Intercepted product prescribing error 19.12 11.42 13 363204 155 50241752
Complications of bone marrow transplant 19.11 11.42 20 363197 446 50241461
Hyperuricaemia 19.07 11.42 5 363212 4675 50237232
Colitis ischaemic 19.05 11.42 24 363193 9459 50232448
Bacterial translocation 19.05 11.42 13 363204 156 50241751
Posterior reversible encephalopathy syndrome 19.04 11.42 50 363167 14878 50227029
Weight decreased 19.04 11.42 1349 361868 219896 50022011
Sleep disorder due to a general medical condition 19 11.42 15 363202 7356 50234551
Multiple sclerosis 18.99 11.42 79 363138 20414 50221493
Azotaemia 18.99 11.42 3 363214 4005 50237902
Eructation 18.98 11.42 14 363203 7107 50234800
Product label confusion 18.98 11.42 21 363196 500 50241407
Contusion 18.98 11.42 637 362580 111546 50130361
Anorectal ulcer 18.93 11.42 9 363208 50 50241857
Colon dysplasia 18.91 11.42 8 363209 32 50241875
Hydronephrosis 18.90 11.42 20 363197 8521 50233386
Hypertonia 18.76 11.42 3 363214 3970 50237937
Bone tuberculosis 18.71 11.42 14 363203 196 50241711
Vulval abscess 18.64 11.42 24 363193 673 50241234
Non-consummation 18.51 11.42 9 363208 53 50241854
Angioedema 18.41 11.42 177 363040 37499 50204408
White blood cell count abnormal 18.37 11.42 8 363209 5432 50236475
Dermatitis contact 18.31 11.42 21 363196 8625 50233282
Orthopnoea 18.22 11.42 9 363208 5680 50236227
Spinal osteoarthritis 18.13 11.42 47 363170 14045 50227862
Rhinitis allergic 18.13 11.42 15 363202 7185 50234722
Gastric ulcer 18.01 11.42 85 363132 21220 50220687
Nerve injury 17.99 11.42 20 363197 8330 50233577
Product storage error 17.94 11.42 38 363179 12186 50229721
Hodgkin's disease stage II 17.85 11.42 6 363211 10 50241897
Dizziness postural 17.83 11.42 11 363206 6134 50235773
Hemiplegia 17.82 11.42 16 363201 7365 50234542
Anal fistula infection 17.82 11.42 7 363210 22 50241885
Patent ductus arteriosus 17.78 11.42 3 363214 3817 50238090
Rash erythematous 17.78 11.42 162 363055 34690 50207217
Cholecystitis acute 17.65 11.42 15 363202 7091 50234816
Extranodal marginal zone B-cell lymphoma (MALT type) 17.59 11.42 19 363198 440 50241467
Muscle strain 17.56 11.42 15 363202 7073 50234834
Plasmablastic lymphoma 17.55 11.42 13 363204 179 50241728
Herpes ophthalmic 17.54 11.42 29 363188 1025 50240882
Pyoderma 17.42 11.42 14 363203 219 50241688
Premature delivery 17.41 11.42 99 363118 23564 50218343
Catheter site pain 17.41 11.42 3 363214 3759 50238148
Presyncope 17.40 11.42 102 363115 24096 50217811
Lip swelling 17.40 11.42 105 363112 24631 50217276
Disseminated coccidioidomycosis 17.35 11.42 8 363209 41 50241866
Nephropathy 17.33 11.42 8 363209 5250 50236657
Ectopic pregnancy 17.31 11.42 46 363171 2281 50239626
Catatonia 17.25 11.42 3 363214 3733 50238174
Hepatomegaly 17.18 11.42 32 363185 10761 50231146
Euphoric mood 17.17 11.42 4 363213 4051 50237856
Unintended pregnancy 17.14 11.42 7 363210 4939 50236968
Erythema multiforme 17.06 11.42 24 363193 9026 50232881
Bundle branch block right 17.05 11.42 6 363211 4639 50237268
Skin abrasion 17.03 11.42 20 363197 8130 50233777
Tongue disorder 17.03 11.42 119 363098 9097 50232810
Paternal exposure during pregnancy 17.00 11.42 9 363208 65 50241842
Non-cardiac chest pain 17.00 11.42 10 363207 5722 50236185
Drug-induced liver injury 16.88 11.42 125 363092 27970 50213937
Gastrointestinal stoma complication 16.87 11.42 35 363182 1475 50240432
Spleen tuberculosis 16.81 11.42 5 363212 4 50241903
Hodgkin's disease mixed cellularity stage unspecified 16.81 11.42 5 363212 4 50241903
Live birth 16.78 11.42 186 363031 16222 50225685
Hyperaemia 16.77 11.42 42 363175 2008 50239899
Cardiac pacemaker insertion 16.72 11.42 3 363214 3650 50238257
Electrocardiogram abnormal 16.62 11.42 18 363199 7587 50234320
Rectal cancer metastatic 16.56 11.42 14 363203 236 50241671
Left ventricular hypertrophy 16.56 11.42 7 363210 4838 50237069
Oropharyngeal cancer 16.54 11.42 7 363210 28 50241879
Bedridden 16.53 11.42 26 363191 9341 50232566
Bone density decreased 16.53 11.42 136 363081 10939 50230968
Initial insomnia 16.52 11.42 8 363209 5107 50236800
Atrioventricular block second degree 16.51 11.42 3 363214 3618 50238289
Haemorrhagic diathesis 16.51 11.42 4 363213 3944 50237963
Neoplasm skin 16.48 11.42 28 363189 1012 50240895
Retching 16.47 11.42 43 363174 12819 50229088
Adjustment disorder with depressed mood 16.44 11.42 51 363166 2763 50239144
Epstein-Barr virus associated lymphoproliferative disorder 16.41 11.42 37 363180 1652 50240255
Oral discomfort 16.41 11.42 20 363197 7997 50233910
Vasculitis 16.38 11.42 163 363054 13828 50228079
Oral mucosal blistering 16.37 11.42 7 363210 4805 50237102
Crying 16.36 11.42 83 363134 20333 50221574
Brain natriuretic peptide increased 16.36 11.42 6 363211 4521 50237386
Large intestine anastomosis 16.35 11.42 7 363210 29 50241878
Hepatitis cholestatic 16.34 11.42 12 363205 6105 50235802
Laryngeal cancer 16.33 11.42 11 363206 129 50241778
Scleroderma 16.30 11.42 7 363210 4794 50237113
Multiple system atrophy 16.30 11.42 13 363204 201 50241706
Stupor 16.27 11.42 3 363214 3580 50238327
Intermenstrual bleeding 16.18 11.42 15 363202 6799 50235108
Feeling hot 16.18 11.42 382 362835 38820 50203087
Colorectal cancer 16.18 11.42 33 363184 1374 50240533
Central nervous system lesion 16.13 11.42 27 363190 9462 50232445
Diastolic dysfunction 16.08 11.42 9 363208 5293 50236614
Drug dependence 16.02 11.42 80 363137 19679 50222228
Blood thyroid stimulating hormone decreased 16.00 11.42 5 363212 4167 50237740
Metabolic disorder 15.99 11.42 9 363208 5277 50236630
Proctitis ulcerative 15.99 11.42 14 363203 248 50241659
Squamous cell carcinoma of the vagina 15.98 11.42 6 363211 16 50241891
Vein rupture 15.97 11.42 25 363192 843 50241064
Diffuse large B-cell lymphoma stage II 15.93 11.42 8 363209 51 50241856
Gastrointestinal fistula 15.90 11.42 17 363200 389 50241518
Hypoxic-ischaemic encephalopathy 15.85 11.42 4 363213 3838 50238069
Haemolysis 15.82 11.42 12 363205 6004 50235903
Blood uric acid increased 15.81 11.42 4 363213 3830 50238077
Hospitalisation 15.78 11.42 369 362848 67568 50174339
Anal dilatation 15.78 11.42 4 363213 0 50241907
Malignant melanoma of sites other than skin 15.78 11.42 4 363213 0 50241907
Sydenham's chorea 15.78 11.42 4 363213 0 50241907
Tonsillar neoplasm 15.78 11.42 4 363213 0 50241907
Infection in an immunocompromised host 15.77 11.42 18 363199 444 50241463
Gout 15.74 11.42 37 363180 11433 50230474
Dysplasia 15.73 11.42 22 363195 669 50241238
Cystitis 15.72 11.42 225 362992 44339 50197568
Haemorrhagic stroke 15.68 11.42 9 363208 5219 50236688
Dyslipidaemia 15.67 11.42 12 363205 5976 50235931
Blood chloride decreased 15.66 11.42 8 363209 4953 50236954
Therapy change 15.66 11.42 9 363208 5216 50236691
Urticarial vasculitis 15.58 11.42 20 363197 559 50241348
Incontinence 15.54 11.42 30 363187 9955 50231952
Malignant melanoma in situ 15.51 11.42 24 363193 801 50241106
Blood glucose abnormal 15.48 11.42 15 363202 6657 50235250
Anorectal operation 15.48 11.42 6 363211 18 50241889
Vitamin D deficiency 15.47 11.42 37 363180 11365 50230542
Bursitis infective 15.46 11.42 30 363187 1204 50240703
Hypovolaemic shock 15.46 11.42 9 363208 5179 50236728
Ovarian cancer metastatic 15.41 11.42 23 363194 743 50241164
Graft versus host disease 15.33 11.42 13 363204 6153 50235754
Urine analysis abnormal 15.33 11.42 6 363211 4344 50237563
Vasculitis necrotising 15.31 11.42 19 363198 513 50241394
Pericardial effusion 15.30 11.42 114 363103 25475 50216432
Fibromyalgia 15.26 11.42 427 362790 44551 50197356
Low density lipoprotein increased 15.18 11.42 11 363206 5635 50236272
Partial seizures 15.13 11.42 8 363209 4857 50237050
Drug screen positive 15.13 11.42 3 363214 3399 50238508
Aortic arteriosclerosis 15.12 11.42 10 363207 5372 50236535
COVID-19 pneumonia 15.11 11.42 23 363194 8372 50233535
Acute pulmonary oedema 15.01 11.42 18 363199 7249 50234658
Monocyte count increased 15.01 11.42 79 363138 5460 50236447
Influenza 15.00 11.42 509 362708 89029 50152878
Osteoporosis 15.00 11.42 229 362988 44650 50197257
Psychiatric symptom 14.99 11.42 7 363210 4563 50237344
COVID-19 14.95 11.42 240 362977 46422 50195485
Tachypnoea 14.91 11.42 54 363163 14523 50227384
Postoperative wound infection 14.83 11.42 108 363109 8367 50233540
Foot fracture 14.81 11.42 84 363133 20007 50221900
Vitreous floaters 14.76 11.42 10 363207 5304 50236603
IgA nephropathy 14.74 11.42 17 363200 424 50241483
Creatinine urine abnormal 14.71 11.42 7 363210 39 50241868
Orbital apex syndrome 14.71 11.42 7 363210 39 50241868
Myopathy 14.63 11.42 27 363190 9112 50232795
Dysphoria 14.63 11.42 8 363209 4766 50237141
Hyperthyroidism 14.62 11.42 42 363175 12133 50229774
Body temperature decreased 14.61 11.42 181 363036 16214 50225693
Cytomegalovirus gastrointestinal infection 14.60 11.42 14 363203 280 50241627
Septic shock 14.58 11.42 306 362911 56869 50185038
Hepatotoxicity 14.57 11.42 125 363092 27101 50214806
Cerebellar syndrome 14.56 11.42 3 363214 3308 50238599
Body height decreased 14.54 11.42 26 363191 8882 50233025
Perineal abscess 14.49 11.42 13 363204 238 50241669
Vitamin B12 deficiency 14.48 11.42 5 363212 3911 50237996
Streptococcal infection 14.47 11.42 70 363147 4678 50237229
Vaginal flatulence 14.45 11.42 13 363204 239 50241668
Back disorder 14.45 11.42 28 363189 9277 50232630
Adjusted calcium decreased 14.38 11.42 10 363207 124 50241783
Nasopharyngeal cancer 14.38 11.42 6 363211 23 50241884
Enterocolonic fistula 14.38 11.42 6 363211 23 50241884
Hypertriglyceridaemia 14.38 11.42 11 363206 5480 50236427
Latent tuberculosis 14.37 11.42 42 363175 2201 50239706
Arteriosclerosis 14.37 11.42 27 363190 9050 50232857
Intervertebral disc degeneration 14.35 11.42 49 363168 13412 50228495
Skin laceration 14.32 11.42 78 363139 18764 50223143
Superficial spreading melanoma stage unspecified 14.31 11.42 10 363207 125 50241782
Retroperitoneal abscess 14.31 11.42 10 363207 125 50241782
Salpingo-oophorectomy 14.30 11.42 5 363212 10 50241897
Joint stiffness 14.30 11.42 301 362916 30007 50211900
Ocular sarcoidosis 14.29 11.42 7 363210 42 50241865
Muscle tightness 14.23 11.42 33 363184 10247 50231660
Spinal compression fracture 14.23 11.42 45 363172 12611 50229296
Neutrophilia 14.23 11.42 4 363213 3571 50238336
Limb injury 14.22 11.42 86 363131 20164 50221743
Hypersomnia 14.21 11.42 59 363158 15255 50226652
Tonsil cancer 14.21 11.42 12 363205 202 50241705
Precancerous cells present 14.21 11.42 29 363188 1208 50240699
Gangrene 14.18 11.42 8 363209 4684 50237223
Loose tooth 14.17 11.42 3 363214 3247 50238660
Gastrointestinal stoma output abnormal 14.15 11.42 7 363210 43 50241864
Blood glucose fluctuation 14.15 11.42 6 363211 4140 50237767
Steroid dependence 14.14 11.42 15 363202 340 50241567
Toxic skin eruption 14.11 11.42 38 363179 11213 50230694
Pharyngeal paraesthesia 14.07 11.42 32 363185 1437 50240470
Laryngeal disorder 14.04 11.42 24 363193 872 50241035
Peripheral arterial occlusive disease 14.00 11.42 4 363213 3533 50238374
Pelvic pain 13.97 11.42 38 363179 11175 50230732
Failure to thrive 13.95 11.42 15 363202 6343 50235564
Infected cyst 13.87 11.42 23 363194 815 50241092
Enterocolitis 13.85 11.42 16 363201 6551 50235356
Serum sickness-like reaction 13.84 11.42 17 363200 454 50241453
Vulval disorder 13.83 11.42 21 363196 689 50241218
Increased tendency to bruise 13.80 11.42 29 363188 9327 50232580
Circumstance or information capable of leading to medication error 13.79 11.42 3 363214 3185 50238722
Intestinal ulcer 13.79 11.42 27 363190 1091 50240816
Ear infection bacterial 13.77 11.42 7 363210 46 50241861
Blood phosphorus decreased 13.73 11.42 5 363212 3784 50238123
Antibody test abnormal 13.72 11.42 17 363200 458 50241449
Lacrimation increased 13.66 11.42 69 363148 16923 50224984
Histone antibody positive 13.65 11.42 8 363209 72 50241835
Adrenal atrophy 13.63 11.42 6 363211 27 50241880
Meningitis coccidioides 13.63 11.42 6 363211 27 50241880
Infected fistula 13.62 11.42 9 363208 102 50241805
Pharyngitis streptococcal 13.60 11.42 109 363108 8699 50233208
Ear injury 13.59 11.42 11 363206 174 50241733
Enteropathy-associated T-cell lymphoma 13.56 11.42 4 363213 3 50241904
Respiratory tract carcinoma in situ 13.56 11.42 4 363213 3 50241904
Endometrial neoplasm 13.56 11.42 4 363213 3 50241904
Pericarditis lupus 13.56 11.42 4 363213 3 50241904
Ventricular septal defect 13.55 11.42 6 363211 4035 50237872
Hypercholesterolaemia 13.54 11.42 136 363081 11567 50230340
Genital cyst 13.52 11.42 7 363210 48 50241859
Tonsillitis streptococcal 13.52 11.42 7 363210 48 50241859
Gastroenteritis salmonella 13.47 11.42 18 363199 524 50241383
Oesophagitis 13.41 11.42 50 363167 13333 50228574
Stoma obstruction 13.41 11.42 5 363212 13 50241894
Brain injury 13.40 11.42 14 363203 6000 50235907
Intentional dose omission 13.37 11.42 10 363207 5040 50236867
Viral pericarditis 13.29 11.42 6 363211 29 50241878
Anastomotic ulcer 13.28 11.42 13 363204 267 50241640
Hunger 13.27 11.42 7 363210 4256 50237651
Incorrect route of product administration 13.25 11.42 79 363138 18587 50223320
Lip and/or oral cavity cancer 13.24 11.42 14 363203 316 50241591
Joint injury 13.24 11.42 225 362992 21564 50220343
Cytomegalovirus colitis 13.24 11.42 37 363180 1890 50240017
C-reactive protein decreased 13.23 11.42 22 363195 781 50241126
Skin hypertrophy 13.21 11.42 3 363214 3092 50238815
Ventricular hypokinesia 13.20 11.42 6 363211 3974 50237933
End stage renal disease 13.19 11.42 13 363204 5724 50236183
Clostridium difficile colitis 13.18 11.42 74 363143 17668 50224239
Skin atrophy 13.17 11.42 7 363210 4238 50237669
Foetal exposure during pregnancy 13.17 11.42 129 363088 27230 50214677
Cholecystitis 13.15 11.42 53 363164 13818 50228089
Panic attack 13.14 11.42 83 363134 19259 50222648
Uterine carcinoma in situ 13.13 11.42 6 363211 30 50241877
Bartholinitis 13.13 11.42 6 363211 30 50241877
Eye pruritus 13.11 11.42 46 363171 12488 50229419
Pulmonary function test decreased 13.10 11.42 4 363213 3384 50238523
Myelitis 13.09 11.42 28 363189 1206 50240701
Acute graft versus host disease 13.08 11.42 6 363211 3952 50237955
Coronary artery occlusion 13.08 11.42 21 363196 7482 50234425
Device related infection 13.07 11.42 91 363126 20644 50221263
Tooth loss 13.05 11.42 15 363202 6155 50235752
Ileal ulcer 13.03 11.42 16 363201 427 50241480
Hodgkin's disease nodular sclerosis 13.03 11.42 4 363213 4 50241903
Bladder repair 13.03 11.42 8 363209 79 50241828
Pathogen resistance 12.96 11.42 13 363204 5676 50236231
Hair texture abnormal 12.95 11.42 5 363212 3651 50238256
Post transplant lymphoproliferative disorder 12.95 11.42 7 363210 4197 50237710
Dyspnoea at rest 12.90 11.42 5 363212 3642 50238265
Hereditary angioedema 12.90 11.42 12 363205 5430 50236477
Cerebral ischaemia 12.89 11.42 14 363203 5894 50236013
Pleuropericarditis 12.89 11.42 12 363205 231 50241676
Cutaneous leishmaniasis 12.86 11.42 8 363209 81 50241826
Hepatitis 12.86 11.42 154 363063 31299 50210608
Wisdom teeth removal 12.80 11.42 16 363201 435 50241472
Appetite disorder 12.78 11.42 15 363202 6099 50235808
Low birth weight baby 12.76 11.42 14 363203 5867 50236040
Optic neuritis 12.75 11.42 89 363128 6801 50235106
Gastrointestinal toxicity 12.72 11.42 9 363208 4668 50237239
Serum amyloid A protein increased 12.71 11.42 9 363208 115 50241792
Vulval cancer stage 0 12.71 11.42 9 363208 115 50241792
Rash papular 12.69 11.42 47 363170 12557 50229350
Sluggishness 12.67 11.42 8 363209 4405 50237502
Intestinal ischaemia 12.66 11.42 18 363199 6739 50235168
Postoperative abscess 12.63 11.42 14 363203 334 50241573
Ventricular arrhythmia 12.63 11.42 4 363213 3305 50238602
Hypertonic bladder 12.62 11.42 3 363214 2997 50238910
Omphalitis 12.62 11.42 8 363209 84 50241823
Jejunectomy 12.57 11.42 4 363213 5 50241902
Myocardial ischaemia 12.57 11.42 42 363175 11571 50230336
Perineal fistula 12.53 11.42 6 363211 34 50241873
Sexual dysfunction 12.52 11.42 4 363213 3288 50238619
Occult blood positive 12.52 11.42 4 363213 3287 50238620
Neck surgery 12.51 11.42 31 363186 1472 50240435
Ovarian epithelial cancer 12.49 11.42 13 363204 288 50241619
Nasal septum disorder 12.46 11.42 9 363208 119 50241788
Normal newborn 12.36 11.42 18 363199 6673 50235234
Injection site irritation 12.33 11.42 8 363209 4342 50237565
Increased appetite 12.27 11.42 26 363191 8335 50233572
Major depression 12.25 11.42 19 363198 6865 50235042
DNA antibody 12.25 11.42 6 363211 36 50241871
Malignant melanoma stage I 12.25 11.42 6 363211 36 50241871
Sinus congestion 12.25 11.42 55 363162 13916 50227991
Photophobia 12.23 11.42 60 363157 14827 50227080
Thoracic vertebral fracture 12.23 11.42 7 363210 4066 50237841
Crepitations 12.22 11.42 16 363201 6203 50235704
Anorectal stenosis 12.22 11.42 5 363212 18 50241889
Alveolitis 12.19 11.42 43 363174 2491 50239416
Genital herpes 12.19 11.42 32 363185 1575 50240332
Aphthous ulcer 12.19 11.42 123 363094 10474 50231433
Application site pain 12.18 11.42 6 363211 3792 50238115
B-cell lymphoma stage IV 12.15 11.42 4 363213 6 50241901
Vulval neoplasm 12.15 11.42 4 363213 6 50241901
Tuberculosis of central nervous system 12.14 11.42 13 363204 298 50241609
Lung consolidation 12.08 11.42 6 363211 3774 50238133
Catheterisation cardiac 12.05 11.42 7 363210 4033 50237874
Purpura 12.04 11.42 34 363183 9877 50232030
Small intestine adenocarcinoma 12.01 11.42 5 363212 19 50241888
Embolic stroke 11.96 11.42 5 363212 3479 50238428
Diverticulum intestinal 11.93 11.42 15 363202 5918 50235989
Breast neoplasm 11.92 11.42 28 363189 1285 50240622
Electrocardiogram ST segment elevation 11.90 11.42 5 363212 3468 50238439
Necrotising fasciitis streptococcal 11.85 11.42 6 363211 39 50241868
Leishmaniasis 11.85 11.42 7 363210 64 50241843
Angiolipoma 11.83 11.42 3 363214 0 50241907
Paget's disease of nipple 11.83 11.42 3 363214 0 50241907
Chronic granulomatous disease 11.83 11.42 3 363214 0 50241907
Mastoidectomy 11.83 11.42 3 363214 0 50241907
Lung squamous cell carcinoma stage III 11.83 11.42 3 363214 0 50241907
Panel-reactive antibody 11.83 11.42 3 363214 0 50241907
Faecal calprotectin 11.83 11.42 3 363214 0 50241907
Juvenile melanoma benign 11.83 11.42 3 363214 0 50241907
Biliary neoplasm 11.83 11.42 3 363214 0 50241907
Tuberculosis of genitourinary system 11.83 11.42 3 363214 0 50241907
Systemic viral infection 11.83 11.42 3 363214 0 50241907
Atrial septal defect 11.77 11.42 17 363200 6324 50235583
Galactorrhoea 11.76 11.42 6 363211 3717 50238190
Facial pain 11.73 11.42 23 363194 7586 50234321
Blood parathyroid hormone increased 11.72 11.42 3 363214 2851 50239056
Incoherent 11.69 11.42 8 363209 4222 50237685
Renal function test abnormal 11.69 11.42 3 363214 2846 50239061
Onychoclasis 11.69 11.42 12 363205 5184 50236723
Nail operation 11.68 11.42 16 363201 477 50241430
Hyperadrenocorticism 11.67 11.42 13 363204 312 50241595
Anal skin tags 11.63 11.42 13 363204 313 50241594
Obesity 11.61 11.42 177 363040 16598 50225309
Jaw disorder 11.60 11.42 11 363206 4932 50236975
Metastatic squamous cell carcinoma 11.60 11.42 11 363206 217 50241690
Eating disorder 11.59 11.42 64 363153 15345 50226562
Ulcerative keratitis 11.58 11.42 40 363177 2293 50239614
Vaginal haematoma 11.57 11.42 9 363208 134 50241773
Blood urine present 11.56 11.42 50 363167 12783 50229124
Diffuse alveolar damage 11.56 11.42 21 363196 801 50241106
Abortion incomplete 11.54 11.42 4 363213 3122 50238785
Sarcoma 11.54 11.42 14 363203 369 50241538
Supraventricular extrasystoles 11.53 11.42 7 363210 3937 50237970
Staphylococcus test positive 11.51 11.42 5 363212 3401 50238506
Drug tolerance 11.50 11.42 68 363149 4908 50236999
Haemophilus infection 11.48 11.42 24 363193 1017 50240890
Parosmia 11.47 11.42 9 363208 4427 50237480
Eye infection toxoplasmal 11.45 11.42 12 363205 268 50241639
Portal hypertension 11.43 11.42 5 363212 3387 50238520

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Infusion related reaction 4460.70 12.15 2779 148417 41107 29382224
Off label use 3362.53 12.15 5699 145497 295101 29128230
Product use issue 3343.82 12.15 2471 148725 48973 29374358
Intentional product use issue 1892.88 12.15 1637 149559 40861 29382470
Drug ineffective 1558.67 12.15 4710 146486 358460 29064871
Inappropriate schedule of product administration 1398.67 12.15 1412 149784 43060 29380271
Blood pressure fluctuation 1339.88 12.15 978 150218 18916 29404415
Tuberculosis 999.71 12.15 559 150637 6637 29416694
Intestinal resection 954.34 12.15 337 150859 1125 29422206
Condition aggravated 880.06 12.15 2155 149041 144140 29279191
Pulmonary tuberculosis 767.15 12.15 395 150801 3920 29419411
Acute kidney injury 749.50 12.15 215 150981 265052 29158279
Drug level below therapeutic 719.23 12.15 377 150819 3894 29419437
Disseminated tuberculosis 712.80 12.15 295 150901 1667 29421664
Lupus-like syndrome 711.49 12.15 307 150889 1955 29421376
Toxicity to various agents 708.01 12.15 46 151150 173615 29249716
Drug specific antibody present 697.08 12.15 314 150882 2247 29421084
Frequent bowel movements 690.13 12.15 484 150712 8755 29414576
Fistula 678.01 12.15 386 150810 4753 29418578
Death 673.38 12.15 465 150731 341619 29081712
Drug interaction 649.18 12.15 114 151082 197271 29226060
Haematochezia 566.14 12.15 815 150381 36168 29387163
Skin cancer 510.98 12.15 390 150806 8078 29415253
Heart rate decreased 508.59 12.15 632 150564 24280 29399051
Febrile neutropenia 456.26 12.15 30 151166 112210 29311121
Joint swelling 443.50 12.15 859 150337 48771 29374560
Therapeutic product effect decreased 443.30 12.15 644 150552 28807 29394524
Arthralgia 440.92 12.15 1640 149556 137977 29285354
Colectomy 436.95 12.15 193 151003 1310 29422021
Anal abscess 412.99 12.15 284 150912 4967 29418364
Anal fistula 397.93 12.15 255 150941 3940 29419391
Lymphoma 389.65 12.15 355 150841 9473 29413858
Flushing 382.25 12.15 596 150600 28396 29394935
Drug abuse 381.92 12.15 5 151191 79878 29343453
Apparent death 359.90 12.15 224 150972 3280 29420051
Weight increased 344.98 12.15 1016 150180 75651 29347680
Therapeutic response shortened 341.55 12.15 244 150952 4547 29418784
Heart rate irregular 337.88 12.15 375 150821 12742 29410589
Synovitis 334.78 12.15 342 150854 10548 29412783
Anaemia 329.93 12.15 325 150871 200626 29222705
Thrombocytopenia 322.35 12.15 143 151053 134680 29288651
Drug level decreased 321.51 12.15 262 150934 5985 29417346
Drug intolerance 316.92 12.15 738 150458 47641 29375690
Faecal calprotectin increased 315.82 12.15 156 151040 1405 29421926
Urticaria 315.49 12.15 794 150402 53866 29369465
Completed suicide 312.21 12.15 45 151151 90201 29333130
Blood pressure increased 309.34 12.15 954 150242 72849 29350482
Contraindicated product administered 306.73 12.15 421 150775 17845 29405486
Herpes zoster 300.49 12.15 546 150650 29506 29393825
Basal cell carcinoma 299.53 12.15 400 150796 16510 29406821
Neutropenia 294.53 12.15 153 151043 131558 29291773
Confusional state 291.24 12.15 145 151051 127732 29295599
Abscess 284.62 12.15 298 150898 9464 29413867
Intestinal stenosis 276.74 12.15 152 151044 1736 29421595
Platelet count decreased 276.55 12.15 95 151101 104577 29318754
Treatment failure 273.79 12.15 592 150604 36347 29386984
Hypersensitivity 271.99 12.15 736 150460 52167 29371164
Histoplasmosis 260.99 12.15 131 151065 1225 29422106
Overdose 253.52 12.15 50 151146 79769 29343562
Malignant neoplasm progression 252.72 12.15 38 151158 73821 29349510
C-reactive protein abnormal 247.23 12.15 230 150966 6306 29417025
Ileal stenosis 246.20 12.15 122 151074 1107 29422224
Hyperkalaemia 241.86 12.15 19 151177 61373 29361958
Blood creatinine increased 241.31 12.15 68 151128 85034 29338297
Clostridium difficile infection 231.28 12.15 345 150851 15796 29407535
Pneumonia legionella 224.72 12.15 125 151071 1466 29421865
Malignant melanoma 223.92 12.15 227 150969 6934 29416397
Arthropathy 223.59 12.15 398 150798 21156 29402175
Disease progression 222.18 12.15 71 151125 81845 29341486
Histoplasmosis disseminated 218.66 12.15 110 151086 1034 29422297
Hepatosplenic T-cell lymphoma 218.48 12.15 82 151114 340 29422991
Hyponatraemia 215.53 12.15 42 151154 67591 29355740
Red blood cell sedimentation rate abnormal 211.04 12.15 137 151059 2166 29421165
Diverticulitis 207.37 12.15 345 150851 17359 29405972
Cardiac arrest 207.23 12.15 89 151107 85502 29337829
Lymph node tuberculosis 203.72 12.15 79 151117 365 29422966
Body temperature fluctuation 199.56 12.15 112 151084 1338 29421993
Rhabdomyolysis 197.51 12.15 36 151160 60772 29362559
Somnolence 195.72 12.15 119 151077 93836 29329495
Hypotension 194.59 12.15 442 150754 193912 29229419
Nephrolithiasis 188.79 12.15 407 150789 24927 29398404
Hypoglycaemia 187.54 12.15 16 151180 48330 29375001
Renal impairment 186.89 12.15 91 151105 81242 29342089
Abdominal pain 182.18 12.15 1250 149946 134107 29289224
Intestinal obstruction 173.63 12.15 335 150861 18942 29404389
Neoplasm malignant 173.57 12.15 311 150885 16614 29406717
Incorrect dose administered 172.55 12.15 462 150734 32522 29390809
International normalised ratio increased 171.25 12.15 15 151181 44357 29378974
Poor venous access 169.90 12.15 136 151060 3025 29420306
Hallucination 167.56 12.15 17 151179 44695 29378636
Uveitis 167.04 12.15 178 151018 5769 29417562
Fall 165.34 12.15 418 150778 176760 29246571
Colitis ulcerative 163.34 12.15 259 150937 12510 29410821
Large intestinal stenosis 161.64 12.15 96 151100 1285 29422046
Intentional overdose 160.31 12.15 9 151187 38519 29384812
Cardio-respiratory arrest 159.99 12.15 32 151164 50569 29372762
Neutrophil count decreased 157.10 12.15 19 151177 43548 29379783
Mycobacterium marinum infection 155.97 12.15 58 151138 233 29423098
White blood cell count decreased 155.68 12.15 119 151077 83243 29340088
Systemic lupus erythematosus 154.36 12.15 118 151078 2448 29420883
Anal fissure 153.46 12.15 122 151074 2686 29420645
Bone erosion 151.02 12.15 120 151076 2640 29420691
Pancytopenia 149.93 12.15 123 151073 83045 29340286
Pyoderma gangrenosum 149.56 12.15 84 151112 1005 29422326
Blood glucose increased 148.13 12.15 58 151138 58926 29364405
Disability 147.30 12.15 145 151051 4271 29419060
Cardiac failure congestive 147.28 12.15 106 151090 76475 29346856
Erythema 147 12.15 769 150427 74837 29348494
Chest discomfort 146.14 12.15 542 150654 45441 29377890
Bradycardia 145.41 12.15 77 151119 65552 29357779
Psoriasis 143.67 12.15 426 150770 31801 29391530
Seizure 141.95 12.15 160 151036 92963 29330368
Cardiac failure 140.77 12.15 119 151077 79168 29344163
Drug level above therapeutic 139.93 12.15 124 151072 3186 29420145
Lactic acidosis 139.88 12.15 3 151193 30244 29393087
Meningitis listeria 139.63 12.15 58 151138 331 29423000
Electrocardiogram QT prolonged 137.34 12.15 13 151183 36124 29387207
Tuberculous pleurisy 137.11 12.15 56 151140 304 29423027
Squamous cell carcinoma 136.77 12.15 212 150984 10039 29413292
Drug hypersensitivity 135.20 12.15 699 150497 67707 29355624
Metabolic acidosis 134.38 12.15 17 151179 37645 29385686
Hodgkin's disease 134.34 12.15 72 151124 780 29422551
Delirium 133.04 12.15 21 151175 39376 29383955
Weight decreased 132.85 12.15 1265 149931 149640 29273691
Constipation 132.54 12.15 238 150958 113922 29309409
Antinuclear antibody positive 131.49 12.15 83 151113 1247 29422084
Diarrhoea haemorrhagic 131.12 12.15 156 151040 5718 29417613
Drug specific antibody 128.00 12.15 49 151147 217 29423114
Knee arthroplasty 127.57 12.15 153 151043 5656 29417675
Peritoneal tuberculosis 126.80 12.15 53 151143 308 29423023
Atrial fibrillation 126.49 12.15 216 150980 105430 29317901
Arthritis 126.38 12.15 346 150850 24673 29398658
Gastrointestinal haemorrhage 125.23 12.15 133 151063 79400 29343931
Decreased appetite 124.12 12.15 358 150838 144984 29278347
Rheumatoid arthritis 123.87 12.15 404 150792 31748 29391583
Drug eruption 122.47 12.15 267 150929 16474 29406857
Asthenia 120.92 12.15 628 150568 214622 29208709
Fatigue 119.64 12.15 1041 150155 315780 29107551
Rheumatoid factor negative 119.38 12.15 66 151130 764 29422567
Prostate cancer 119.10 12.15 343 150853 25184 29398147
Colectomy total 118.19 12.15 38 151158 86 29423245
Infusion site extravasation 114.34 12.15 108 151088 3019 29420312
Surgery 113.86 12.15 211 150985 11568 29411763
Coma 112.73 12.15 31 151165 39419 29383912
Hyperglycaemia 111.95 12.15 20 151176 34267 29389064
Aggression 109.20 12.15 24 151172 35517 29387814
Therapeutic product effect incomplete 109.15 12.15 444 150752 38861 29384470
Body temperature decreased 108.10 12.15 195 151001 10469 29412862
Vein rupture 107.69 12.15 58 151138 635 29422696
Hypokalaemia 106.70 12.15 62 151134 50141 29373190
Mental status changes 106.47 12.15 24 151172 34903 29388428
Bone cyst 106.30 12.15 54 151142 519 29422812
Sarcoidosis 105.86 12.15 96 151100 2544 29420787
Non-Hodgkin's lymphoma 103.85 12.15 75 151121 1422 29421909
Depressed level of consciousness 103.75 12.15 30 151166 36912 29386419
Disorientation 103.67 12.15 14 151182 29501 29393830
Respiratory failure 103.55 12.15 213 150983 96918 29326413
Blood urea increased 101.98 12.15 12 151184 28100 29395231
Red blood cell sedimentation rate increased 101.92 12.15 156 151040 7305 29416026
Drug reaction with eosinophilia and systemic symptoms 101.42 12.15 12 151184 27980 29395351
Lymphoproliferative disorder 99.59 12.15 91 151105 2436 29420895
Musculoskeletal stiffness 99.18 12.15 417 150779 37041 29386290
Therapeutic response decreased 98.34 12.15 314 150882 24397 29398934
B-cell lymphoma 98.02 12.15 109 151087 3709 29419622
Rectal abscess 97.99 12.15 61 151135 893 29422438
Loss of personal independence in daily activities 96.49 12.15 318 150878 25122 29398209
Lung neoplasm malignant 96.07 12.15 221 150975 14136 29409195
Agitation 96.04 12.15 73 151123 51231 29372100
Ileostomy 95.61 12.15 48 151148 449 29422882
Dizziness 95.25 12.15 574 150622 189110 29234221
Chondropathy 95.24 12.15 59 151137 856 29422475
Cutaneous leishmaniasis 94.55 12.15 37 151159 176 29423155
Pneumonia aspiration 94.09 12.15 35 151161 36702 29386629
Mucous stools 92.96 12.15 63 151133 1074 29422257
Atlantoaxial instability 92.92 12.15 42 151154 303 29423028
Acute myocardial infarction 91.85 12.15 68 151128 48370 29374961
Henoch-Schonlein purpura 91.44 12.15 66 151130 1250 29422081
Type IV hypersensitivity reaction 91.13 12.15 63 151133 1111 29422220
Dehydration 87.07 12.15 298 150898 114450 29308881
Cholangitis sclerosing 86.95 12.15 59 151137 1008 29422323
Pouchitis 86.13 12.15 48 151148 565 29422766
Spinal instability 84.47 12.15 40 151156 325 29423006
Dislocation of vertebra 84.07 12.15 41 151155 358 29422973
Encephalopathy 83.94 12.15 27 151169 31016 29392315
Mineral metabolism disorder 83.75 12.15 40 151156 332 29422999
Pericarditis 83.55 12.15 156 151040 8601 29414730
Diarrhoea 83.13 12.15 1200 149996 331498 29091833
Hypoxia 81.76 12.15 73 151123 47306 29376025
Pneumocystis jirovecii pneumonia 81.71 12.15 229 150967 16550 29406781
C-reactive protein increased 81.71 12.15 444 150752 43819 29379512
Neuropathy peripheral 81.54 12.15 149 151047 70878 29352453
Plasma cell myeloma 81.51 12.15 44 151152 37071 29386260
Orthostatic hypotension 81.24 12.15 10 151186 22619 29400712
Intestinal operation 80.85 12.15 31 151165 138 29423193
Perirectal abscess 80.80 12.15 64 151132 1401 29421930
Intentional product misuse 80.76 12.15 38 151158 34623 29388708
Suicide attempt 78.55 12.15 38 151158 34072 29389259
Legionella infection 78.47 12.15 41 151155 420 29422911
Pulmonary thrombosis 78.28 12.15 129 151067 6436 29416895
Feeling hot 78.01 12.15 214 150982 15274 29408057
Enthesopathy 77.98 12.15 96 151100 3647 29419684
Enterostomy 77.98 12.15 26 151170 69 29423262
Listeriosis 77.77 12.15 52 151144 866 29422465
Small intestinal resection 77.30 12.15 39 151157 369 29422962
Accidental overdose 76.77 12.15 3 151193 17590 29405741
Onychoclasis 76.76 12.15 67 151129 1686 29421645
Cytomegalovirus colitis 76.69 12.15 78 151118 2391 29420940
Joint ankylosis 76.14 12.15 39 151157 382 29422949
Neoplasm progression 75.45 12.15 5 151191 18607 29404724
Haemoglobin decreased 75.25 12.15 292 150904 108083 29315248
Alanine aminotransferase abnormal 75.19 12.15 84 151112 2873 29420458
Fistula discharge 74.10 12.15 39 151157 406 29422925
Erythema nodosum 73.93 12.15 51 151145 896 29422435
Tenosynovitis 73.39 12.15 93 151103 3640 29419691
Memory impairment 73.38 12.15 48 151148 36422 29386909
Blood creatine phosphokinase increased 73.33 12.15 60 151136 40584 29382747
Drug tolerance decreased 72.53 12.15 58 151138 1288 29422043
Serum sickness 72.38 12.15 65 151131 1700 29421631
Inflammation 72.25 12.15 268 150928 22460 29400871
Oedema peripheral 71.91 12.15 279 150917 103278 29320053
Inflammatory bowel disease 71.77 12.15 73 151123 2238 29421093
Mucosal inflammation 71.54 12.15 36 151160 31559 29391772
Pulmonary oedema 71.18 12.15 68 151128 42667 29380664
Hypervolaemia 70.29 12.15 5 151191 17540 29405791
Demyelination 70.26 12.15 77 151119 2577 29420754
Hypomagnesaemia 69.91 12.15 5 151191 17463 29405868
Proctectomy 69.86 12.15 21 151175 34 29423297
Colon cancer 68.87 12.15 133 151063 7522 29415809
IgA nephropathy 68.85 12.15 51 151145 1007 29422324
Altered state of consciousness 68.52 12.15 10 151186 19879 29403452
Haematuria 68.12 12.15 75 151121 44064 29379267
Impaired quality of life 67.63 12.15 75 151121 2544 29420787
Gastrointestinal inflammation 67.32 12.15 80 151116 2928 29420403
Urinary retention 66.91 12.15 40 151156 31858 29391473
Respiratory arrest 65.50 12.15 25 151171 25808 29397523
Chronic kidney disease 65.40 12.15 54 151142 36362 29386969
Aspartate aminotransferase increased 65.29 12.15 129 151067 59596 29363735
Ileectomy 65.10 12.15 19 151177 26 29423305
Contraindication to vaccination 64.36 12.15 17 151179 11 29423320
Leukopenia 64.07 12.15 115 151081 55088 29368243
Blood alkaline phosphatase increased 63.37 12.15 33 151163 28373 29394958
Cerebrovascular accident 62.99 12.15 193 151003 76718 29346613
Salmonellosis 62.89 12.15 42 151154 698 29422633
Hepatic failure 62.69 12.15 42 151154 31470 29391861
Blood bilirubin increased 62.44 12.15 49 151147 33844 29389487
Extrapulmonary tuberculosis 62.38 12.15 22 151174 73 29423258
Hypophagia 62.30 12.15 15 151181 20857 29402474
Oedema 62.24 12.15 69 151127 40414 29382917
Pallor 61.95 12.15 242 150954 20782 29402549
Coronary artery disease 61.90 12.15 81 151115 44109 29379222
Alanine aminotransferase increased 61.75 12.15 173 151023 70771 29352560
Defaecation urgency 61.27 12.15 59 151137 1690 29421641
Iritis 61.04 12.15 51 151145 1207 29422124
Toxic epidermal necrolysis 60.55 12.15 10 151186 18143 29405188
Irritability 60.36 12.15 19 151177 22133 29401198
Ascites 60.14 12.15 59 151137 36560 29386771
Incorrect drug administration rate 59.82 12.15 49 151147 1127 29422204
Drug withdrawal syndrome 59.78 12.15 10 151186 17974 29405357
Jaundice 59.70 12.15 38 151158 29258 29394073
Psoriatic arthropathy 59.65 12.15 188 151008 14503 29408828
Acne 59.57 12.15 140 151056 9080 29414251
Weight fluctuation 59.46 12.15 88 151108 3998 29419333
Ankylosing spondylitis 59.42 12.15 89 151107 4087 29419244
Joint lock 59.34 12.15 48 151148 1084 29422247
Cognitive disorder 59.15 12.15 23 151173 23476 29399855
Dyskinesia 58.75 12.15 15 151181 20046 29403285
Haemorrhage intracranial 58.67 12.15 4 151192 14538 29408793
Subdural haematoma 58.55 12.15 11 151185 18182 29405149
Wrong technique in product usage process 58.44 12.15 45 151151 31383 29391948
Gamma-glutamyltransferase increased 58.26 12.15 32 151164 26705 29396626
Suicidal ideation 58.10 12.15 55 151141 34661 29388670
Pustular psoriasis 58.04 12.15 54 151142 1480 29421851
Dysphagia 58.02 12.15 121 151075 54805 29368526
Unresponsive to stimuli 57.83 12.15 28 151168 25098 29398233
Dysarthria 57.81 12.15 44 151152 30867 29392464
Hypocalcaemia 57.62 12.15 17 151179 20648 29402683
Balance disorder 57.43 12.15 60 151136 36110 29387221
Cerebral haemorrhage 57.18 12.15 46 151150 31380 29391951
Urinary tract infection 56.83 12.15 185 151011 72169 29351162
Intervertebral disc space narrowing 56.68 12.15 40 151156 730 29422601
Bladder transitional cell carcinoma 55.98 12.15 66 151130 2395 29420936
T-cell lymphoma 55.44 12.15 42 151154 859 29422472
Abscess intestinal 55.26 12.15 51 151145 1383 29421948
Stevens-Johnson syndrome 55.22 12.15 9 151187 16488 29406843
Intestinal fistula 54.35 12.15 41 151155 833 29422498
Dysgeusia 54.15 12.15 24 151172 22650 29400681
Haemoptysis 53.99 12.15 46 151150 30504 29392827
Coccidioidomycosis 53.81 12.15 36 151160 600 29422731
Lethargy 53.55 12.15 68 151128 37512 29385819
Terminal state 53.38 12.15 77 151119 3417 29419914
Hip arthroplasty 53.34 12.15 80 151116 3678 29419653
Fluid retention 53.10 12.15 27 151169 23533 29399798
Oxygen saturation abnormal 53.08 12.15 46 151150 1146 29422185
Arthritis bacterial 53.00 12.15 87 151109 4326 29419005
Small intestinal obstruction 52.90 12.15 167 151029 12894 29410437
Mass 52.66 12.15 114 151082 6997 29416334
Gait disturbance 52.59 12.15 195 151001 73154 29350177
Product quality issue 52.47 12.15 9 151187 15886 29407445
Rectal cancer 52.02 12.15 56 151140 1836 29421495
Tooth loss 51.85 12.15 78 151118 3596 29419735
Cutaneous T-cell lymphoma 51.81 12.15 47 151149 1246 29422085
Tuberculosis gastrointestinal 51.64 12.15 24 151172 186 29423145
Latent tuberculosis 51.52 12.15 43 151153 1016 29422315
Oropharyngeal pain 51.51 12.15 290 150906 28995 29394336
Diabetic ketoacidosis 51.13 12.15 10 151186 16063 29407268
Osteonecrosis of jaw 51.01 12.15 11 151185 16499 29406832
Ischaemic stroke 50.70 12.15 10 151186 15967 29407364
Ventricular tachycardia 50.68 12.15 26 151170 22548 29400783
Full blood count abnormal 50.68 12.15 8 151188 15005 29408326
Pulmonary hypertension 50.63 12.15 16 151180 18592 29404739
Throat tightness 50.61 12.15 112 151084 6979 29416352
Unevaluable event 50.29 12.15 47 151149 29804 29393527
Product use in unapproved indication 50.19 12.15 671 150525 86204 29337127
Rash maculo-papular 50.18 12.15 31 151165 24258 29399073
Bone marrow failure 50.16 12.15 40 151156 27409 29395922
Pain 50.11 12.15 1188 150008 170244 29253087
Skin laceration 50.00 12.15 147 151049 10915 29412416
Abnormal behaviour 49.93 12.15 28 151168 23099 29400232
Cardiogenic shock 49.61 12.15 18 151178 19172 29404159
Diffuse large B-cell lymphoma 49.23 12.15 103 151093 6173 29417158
Cytomegalovirus infection 49.15 12.15 242 150954 22973 29400358
Blood potassium increased 49.02 12.15 8 151188 14643 29408688
Antinuclear antibody increased 48.72 12.15 26 151170 279 29423052
Ileostomy closure 48.66 12.15 16 151180 40 29423291
Hallucination, visual 48.49 12.15 9 151187 15006 29408325
Angioedema 48.39 12.15 55 151141 31860 29391471
Insomnia 47.99 12.15 262 150934 88499 29334832
Tumour lysis syndrome 47.78 12.15 7 151189 13877 29409454
Pregnancy of partner 47.55 12.15 26 151170 294 29423037
Myoclonus 47.48 12.15 6 151190 13303 29410028
Haematocrit decreased 47.38 12.15 47 151149 28975 29394356
Cytology abnormal 47.32 12.15 28 151168 372 29422959
Osteosclerosis 47.17 12.15 42 151154 1086 29422245
Melaena 46.97 12.15 54 151142 31122 29392209
Heart rate increased 46.65 12.15 350 150846 38588 29384743
Upper gastrointestinal haemorrhage 46.64 12.15 27 151169 21887 29401444
Pleural effusion 46.58 12.15 199 150997 71709 29351622
Testicular seminoma (pure) 46.32 12.15 16 151180 49 29423282
Eosinophilia 46.18 12.15 28 151168 22133 29401198
Tongue neoplasm malignant stage unspecified 46.06 12.15 32 151164 569 29422762
Speech disorder 45.89 12.15 32 151164 23484 29399847
Cell marker increased 45.57 12.15 28 151168 400 29422931
Pseudopolyp 45.22 12.15 22 151174 191 29423140
Varicella 45.04 12.15 46 151150 1417 29421914
Pelvic abscess 44.95 12.15 37 151159 857 29422474
Joint arthroplasty 44.92 12.15 33 151163 643 29422688
Injection site pain 44.90 12.15 60 151136 32386 29390945
Impaired work ability 44.76 12.15 93 151103 5547 29417784
Labelled drug-drug interaction medication error 44.57 12.15 5 151191 12154 29411177
Bladder cancer 44.28 12.15 133 151063 9994 29413337
Chills 44.23 12.15 558 150638 70742 29352589
Syncope 44.09 12.15 240 150956 81131 29342200
Proctocolectomy 44.08 12.15 16 151180 59 29423272
Abdominal abscess 44.06 12.15 74 151122 3750 29419581
Hyperbilirubinaemia 44.05 12.15 11 151185 14923 29408408
Renal cell carcinoma 43.98 12.15 83 151113 4613 29418718
Joint stiffness 43.89 12.15 127 151069 9346 29413985
Haematemesis 43.62 12.15 37 151159 24589 29398742
Stomatitis 43.56 12.15 332 150864 36781 29386550
Intentional self-injury 43.54 12.15 6 151190 12455 29410876
Depression 43.51 12.15 256 150940 84891 29338440
Pericarditis tuberculous 43.47 12.15 16 151180 62 29423269
Agranulocytosis 43.37 12.15 25 151171 20315 29403016
Drug use disorder 43.19 12.15 69 151127 3353 29419978
Tooth fracture 43.12 12.15 66 151130 3090 29420241
Bladder neoplasm 43.08 12.15 42 151154 1222 29422109
Tuberculin test positive 42.99 12.15 39 151157 1034 29422297
Glomerular filtration rate decreased 42.94 12.15 4 151192 11262 29412069
Clear cell renal cell carcinoma 42.85 12.15 38 151158 977 29422354
Sinus bradycardia 41.96 12.15 5 151191 11598 29411733
Colostomy 41.86 12.15 26 151170 379 29422952
Anal cancer 41.81 12.15 25 151171 339 29422992
Drug ineffective for unapproved indication 41.38 12.15 163 151033 14051 29409280
Infected fistula 41.22 12.15 17 151179 95 29423236
Angina pectoris 41.14 12.15 49 151147 27801 29395530
Nightmare 41.09 12.15 5 151191 11412 29411919
Haematoma 40.96 12.15 35 151161 23177 29400154
Anaphylactic reaction 40.79 12.15 261 150935 27312 29396019
Disturbance in attention 40.70 12.15 30 151166 21394 29401937
Ventricular fibrillation 40.67 12.15 15 151181 15818 29407513
Psychotic disorder 40.65 12.15 27 151169 20327 29403004
Small intestinal stenosis 40.21 12.15 26 151170 408 29422923
Brain oedema 40.16 12.15 7 151189 12213 29411118
Pharyngitis streptococcal 39.91 12.15 51 151145 2013 29421318
Polyarthritis 39.80 12.15 72 151124 3873 29419458
Physical disability 39.65 12.15 40 151156 1214 29422117
Coagulopathy 39.65 12.15 21 151175 17886 29405445
Poisoning 39.59 12.15 3 151193 9990 29413341
Colon dysplasia 39.42 12.15 17 151179 108 29423223
Colostomy closure 39.40 12.15 13 151183 33 29423298
Loss of consciousness 39.26 12.15 220 150976 73836 29349495
Sinus tachycardia 39.18 12.15 14 151182 15055 29408276
Venous injury 39.11 12.15 22 151174 264 29423067
Serum sickness-like reaction 39.00 12.15 16 151180 88 29423243
Neurotoxicity 38.99 12.15 13 151183 14600 29408731
Multiple sclerosis relapse 38.74 12.15 6 151190 11413 29411918
Acute pulmonary histoplasmosis 38.68 12.15 18 151178 140 29423191
Thyroid cancer 38.66 12.15 41 151155 1321 29422010
Rectal haemorrhage 38.29 12.15 305 150891 34244 29389087
Dry mouth 38.25 12.15 33 151163 21751 29401580
Listeria sepsis 38.14 12.15 18 151178 145 29423186
Intestinal ulcer 38.10 12.15 32 151164 763 29422568
Delusion 37.81 12.15 6 151190 11210 29412121
Hepatic encephalopathy 37.68 12.15 10 151186 13025 29410306
Tongue disorder 37.44 12.15 77 151119 4559 29418772
Medication error 37.40 12.15 32 151164 21179 29402152
Anxiety 37.35 12.15 269 150927 85096 29338235
Appendicectomy 37.30 12.15 32 151164 786 29422545
Chronic obstructive pulmonary disease 37.02 12.15 98 151098 40857 29382474
Anal stenosis 37.00 12.15 17 151179 128 29423203
Pneumonia cryptococcal 36.70 12.15 31 151165 745 29422586
Therapy cessation 36.65 12.15 14 151182 14448 29408883
Double stranded DNA antibody 36.52 12.15 11 151185 18 29423313
Acute respiratory failure 36.35 12.15 49 151147 26353 29396978
Myelosuppression 36.08 12.15 9 151187 12218 29411113
Urine output decreased 35.97 12.15 3 151193 9235 29414096
Erythrodermic psoriasis 35.88 12.15 31 151165 769 29422562
Renal injury 35.44 12.15 5 151191 10197 29413134
Dermatitis psoriasiform 35.43 12.15 36 151160 1102 29422229
Drug-induced liver injury 35.42 12.15 35 151161 21620 29401711
Depressed mood 35.38 12.15 20 151176 16428 29406903
Body temperature increased 35.17 12.15 157 151039 14308 29409023
Hepatocellular injury 35.14 12.15 34 151162 21209 29402122
Anti-cyclic citrullinated peptide antibody positive 35.09 12.15 31 151165 793 29422538
Intestinal sepsis 34.97 12.15 24 151172 418 29422913
Proctalgia 34.87 12.15 71 151125 4174 29419157
Epstein-Barr virus infection 34.78 12.15 93 151103 6536 29416795
Red blood cell count decreased 34.76 12.15 48 151148 25554 29397777
Blood sodium decreased 34.68 12.15 16 151180 14751 29408580
Erectile dysfunction 34.49 12.15 25 151171 17984 29405347
Malaise 34.32 12.15 1063 150133 158539 29264792
Hiccups 34.12 12.15 3 151193 8850 29414481
Mobility decreased 33.91 12.15 237 150959 25543 29397788
Rectal stenosis 33.86 12.15 17 151179 159 29423172
Lung neoplasm 33.78 12.15 71 151125 4269 29419062
Nephropathy toxic 33.57 12.15 7 151189 10749 29412582
Epstein-Barr virus associated lymphoma 33.42 12.15 26 151170 554 29422777
Troponin increased 33.10 12.15 4 151192 9179 29414152
Respiratory depression 32.79 12.15 14 151182 13509 29409822
Blood lactate dehydrogenase increased 32.64 12.15 30 151166 19179 29404152
Rheumatoid factor positive 32.60 12.15 27 151169 631 29422700
No adverse event 32.52 12.15 25 151171 17453 29405878
Hyperlipidaemia 32.22 12.15 12 151184 12578 29410753
Sports injury 32.20 12.15 15 151181 117 29423214
Therapy interrupted 31.90 12.15 3 151193 8383 29414948
Fistula repair 31.86 12.15 9 151187 10 29423321
Small intestine carcinoma 31.80 12.15 24 151172 488 29422843
Cerebral infarction 31.79 12.15 48 151148 24627 29398704
Crohn's disease 31.75 12.15 56 151140 2953 29420378
Neoplasm prostate 31.73 12.15 17 151179 184 29423147
Wisdom teeth removal 31.61 12.15 13 151183 72 29423259
Multiple organ dysfunction syndrome 31.58 12.15 191 151005 62925 29360406
Renal colic 31.57 12.15 40 151156 1565 29421766
Pneumocystis jirovecii infection 31.56 12.15 38 151158 1410 29421921
Septic shock 31.47 12.15 189 151007 62371 29360960
Hepatotoxicity 31.45 12.15 27 151169 17840 29405491
Blood pressure diastolic decreased 31.44 12.15 93 151103 6929 29416402
Faecal calprotectin abnormal 31.42 12.15 17 151179 188 29423143
Renal tubular necrosis 31.38 12.15 17 151179 14298 29409033
DNA antibody positive 31.37 12.15 12 151184 53 29423278
Dystonia 31.14 12.15 6 151190 9743 29413588
Aspiration 31.01 12.15 7 151189 10173 29413158
Dyspnoea exertional 30.98 12.15 90 151106 36400 29386931
Myocardial infarction 30.93 12.15 388 150808 109908 29313423
Mania 30.68 12.15 4 151192 8659 29414672
Treatment noncompliance 30.38 12.15 48 151148 24179 29399152
Cardiac disorder 30.13 12.15 94 151102 37169 29386162
Miosis 30.11 12.15 3 151193 8006 29415325
Enterovesical fistula 29.98 12.15 25 151171 590 29422741
Subcutaneous abscess 29.96 12.15 59 151137 3385 29419946
Product administration error 29.93 12.15 18 151178 14292 29409039
Ankle deformity 29.87 12.15 17 151179 209 29423122
Atrial flutter 29.73 12.15 17 151179 13877 29409454
Injection site papule 29.73 12.15 19 151177 292 29423039
Hyperhidrosis 29.57 12.15 479 150717 64061 29359270
Lymphocyte count decreased 29.44 12.15 33 151163 19238 29404093
White blood cell count increased 29.39 12.15 96 151100 37420 29385911
Ophthalmic herpes zoster 29.23 12.15 27 151169 733 29422598
Prothrombin time prolonged 29.16 12.15 5 151191 8827 29414504
Atypical mycobacterial infection 29.11 12.15 26 151170 675 29422656
Obstructive airways disorder 29.04 12.15 10 151186 11006 29412325
Device issue 29.03 12.15 3 151193 7777 29415554
Subarachnoid haemorrhage 28.86 12.15 7 151189 9685 29413646
Transplant rejection 28.74 12.15 6 151190 9206 29414125
Neutropenic sepsis 28.66 12.15 12 151184 11715 29411616
Adverse event 28.61 12.15 154 151042 15137 29408194
Blood calcium decreased 28.60 12.15 6 151190 9176 29414155
Restlessness 28.60 12.15 43 151153 22102 29401229
Therapy non-responder 28.52 12.15 262 150934 30649 29392682
Rectal tenesmus 28.51 12.15 25 151171 633 29422698
Circulatory collapse 28.50 12.15 32 151164 18641 29404690
Infectious mononucleosis 28.45 12.15 23 151173 519 29422812
Throat irritation 28.25 12.15 104 151092 8681 29414650
Product dose omission issue 28.18 12.15 336 150860 96047 29327284
Generalised tonic-clonic seizure 27.92 12.15 34 151162 19105 29404226
Glycosylated haemoglobin increased 27.69 12.15 7 151189 9419 29413912
Neutrophil count increased 27.54 12.15 21 151175 14721 29408610
Mononeuropathy multiplex 27.52 12.15 14 151182 135 29423196
Ageusia 27.52 12.15 6 151190 8932 29414399
Cutaneous lymphoma 27.47 12.15 12 151184 79 29423252
Dyspepsia 27.29 12.15 72 151124 30053 29393278
Injection site erythema 27.22 12.15 19 151177 13937 29409394
Hypernatraemia 27.17 12.15 3 151193 7383 29415948
Gastric haemorrhage 27.13 12.15 7 151189 9290 29414041
Antibody test positive 27.07 12.15 24 151172 617 29422714
Renal failure 26.97 12.15 435 150761 118164 29305167
Wrist fracture 26.91 12.15 36 151160 1487 29421844
Listeria encephalitis 26.73 12.15 10 151186 41 29423290
Testis cancer 26.66 12.15 28 151168 892 29422439
Adenocarcinoma 26.58 12.15 37 151159 1588 29421743
Enterocutaneous fistula 26.57 12.15 26 151170 760 29422571
Vomiting 26.52 12.15 855 150341 211405 29211926
Acute hepatic failure 26.48 12.15 14 151182 11938 29411393
Colitis 26.42 12.15 260 150936 30988 29392343
Haemodialysis 26.30 12.15 9 151187 9945 29413386
Cholestasis 26.21 12.15 50 151146 23412 29399919
Pneumonia 26.06 12.15 1355 149841 318817 29104514
Pyoderma 25.93 12.15 12 151184 92 29423239
Pathogen resistance 25.92 12.15 5 151191 8111 29415220
Oral surgery 25.83 12.15 22 151174 535 29422796
Exposure during pregnancy 25.82 12.15 6 151190 8548 29414783
Blood cholesterol increased 25.74 12.15 25 151171 15570 29407761
Burn infection 25.69 12.15 6 151190 0 29423331
Hodgkin's disease nodular sclerosis 25.67 12.15 7 151189 6 29423325
Epilepsy 25.58 12.15 34 151162 18398 29404933
Contusion 25.46 12.15 78 151118 31017 29392314
Osteoarthritis 25.33 12.15 169 151027 17934 29405397
Angina unstable 25.17 12.15 12 151184 10853 29412478
Drug specific antibody absent 25.15 12.15 10 151186 50 29423281
Pulmonary arterial hypertension 25.07 12.15 4 151192 7445 29415886
Atelectasis 25.03 12.15 25 151171 15367 29407964
Gastrointestinal carcinoma 24.87 12.15 31 151165 1193 29422138
Antiphospholipid syndrome 24.82 12.15 19 151177 395 29422936
Seronegative arthritis 24.79 12.15 27 151169 897 29422434
Pyrexia 24.79 12.15 1210 149986 286412 29136919
Eosinophil count increased 24.71 12.15 4 151192 7365 29415966
Seminoma 24.67 12.15 15 151181 210 29423121
Mental impairment 24.62 12.15 8 151188 9133 29414198
Overgrowth bacterial 24.58 12.15 12 151184 105 29423226
Injury 24.58 12.15 37 151159 19009 29404322
Intestinal perforation 24.57 12.15 94 151102 7992 29415339
Periumbilical abscess 24.38 12.15 10 151186 55 29423276
Substance abuse 24.36 12.15 3 151193 6784 29416547
Paranoia 24.31 12.15 10 151186 9867 29413464
Ataxia 24.24 12.15 16 151180 12087 29411244
Skin mass 24.14 12.15 54 151142 3389 29419942
Product prescribing error 24.10 12.15 34 151162 17942 29405389
Muscle rigidity 24.03 12.15 9 151187 9402 29413929
Cardiomegaly 24.03 12.15 21 151175 13755 29409576
Prerenal failure 23.88 12.15 37 151159 1751 29421580
Hand fracture 23.78 12.15 35 151161 1582 29421749
Haemodynamic instability 23.71 12.15 6 151190 8067 29415264
Scleral discolouration 23.55 12.15 15 151181 229 29423102
Cyanosis 23.52 12.15 117 151079 11150 29412181
Anastomotic ulcer 23.30 12.15 16 151180 279 29423052
Genital cancer male 23.27 12.15 6 151190 3 29423328
Aplastic anaemia 23.21 12.15 5 151191 7505 29415826
Proctitis 23.09 12.15 40 151156 2079 29421252
Hypophosphataemia 23.06 12.15 6 151190 7918 29415413
Myeloid leukaemia 22.89 12.15 17 151179 337 29422994
Leukocytosis 22.80 12.15 46 151150 21096 29402235
Blood pressure diastolic increased 22.76 12.15 55 151141 3631 29419700
Salivary hypersecretion 22.76 12.15 5 151191 7404 29415927
Tooth infection 22.59 12.15 71 151125 5468 29417863
Gastrointestinal cancer metastatic 22.50 12.15 10 151186 69 29423262
Hypothyroidism 22.43 12.15 29 151167 15877 29407454
Hidradenitis 22.40 12.15 23 151173 713 29422618
Mycobacterium tuberculosis complex test positive 22.34 12.15 27 151169 1006 29422325
Transient ischaemic attack 22.33 12.15 54 151142 23216 29400115
Mitral valve incompetence 22.30 12.15 21 151175 13272 29410059
Urinary incontinence 22.27 12.15 31 151165 16450 29406881
Aphasia 22.26 12.15 40 151156 19158 29404173
Postoperative abscess 22.15 12.15 13 151183 170 29423161
Injection site reaction 22.13 12.15 15 151181 11173 29412158
Tooth abscess 22.06 12.15 66 151130 4948 29418383
Acidosis 22.05 12.15 11 151185 9694 29413637
Spleen tuberculosis 22.03 12.15 7 151189 15 29423316
Renal neoplasm 21.91 12.15 28 151168 1105 29422226
Diabetes mellitus inadequate control 21.77 12.15 18 151178 12116 29411215
Laryngeal cancer 21.72 12.15 22 151174 671 29422660
Ejection fraction decreased 21.64 12.15 30 151166 15948 29407383
Hodgkin's disease stage II 21.56 12.15 6 151190 6 29423325
Phototherapy 21.54 12.15 8 151188 32 29423299
White coat hypertension 21.43 12.15 9 151187 53 29423278
Cortical dysplasia 21.41 12.15 5 151191 0 29423331
Aphthous ulcer 21.27 12.15 57 151139 4011 29419320
Fear 21.25 12.15 11 151185 9493 29413838
Gastrointestinal infection 21.20 12.15 55 151141 3796 29419535
Oesophageal adenocarcinoma 21.17 12.15 23 151173 762 29422569
Malignant melanoma stage I 20.94 12.15 10 151186 83 29423248
Lip and/or oral cavity cancer 20.79 12.15 15 151181 284 29423047
Psychomotor hyperactivity 20.73 12.15 8 151188 8205 29415126
Sepsis 20.72 12.15 563 150633 142119 29281212
Myelodysplastic syndrome 20.69 12.15 37 151159 17757 29405574
Squamous cell carcinoma of lung 20.65 12.15 33 151163 1604 29421727
Breast feeding 20.64 12.15 6 151190 8 29423323
Chromaturia 20.58 12.15 21 151175 12781 29410550
Throat cancer 20.55 12.15 23 151173 788 29422543
Sacroiliitis 20.47 12.15 27 151169 1100 29422231
Osteolysis 20.36 12.15 32 151164 1533 29421798
Cystitis escherichia 20.31 12.15 12 151184 159 29423172
Parkinsonism 20.26 12.15 6 151190 7272 29416059
Opportunistic infection 20.15 12.15 31 151165 1458 29421873
Hypovolaemia 20.03 12.15 8 151188 8037 29415294
Emotional distress 19.94 12.15 25 151171 13870 29409461
Acute graft versus host disease 19.89 12.15 3 151193 5821 29417510
Blood potassium decreased 19.89 12.15 31 151165 15703 29407628
Inappropriate antidiuretic hormone secretion 19.88 12.15 16 151180 10916 29412415
Scleritis 19.87 12.15 15 151181 305 29423026
Pollakiuria 19.83 12.15 35 151161 16881 29406450
Alopecia 19.81 12.15 166 151030 18918 29404413
Tuberculosis of central nervous system 19.77 12.15 11 151185 129 29423202
Cutaneous nocardiosis 19.77 12.15 11 151185 129 29423202
Cytomegalovirus enteritis 19.77 12.15 17 151179 419 29422912
Pain in extremity 19.74 12.15 720 150476 109713 29313618
Antibody test abnormal 19.70 12.15 11 151185 130 29423201
Gastrointestinal stoma complication 19.64 12.15 27 151169 1145 29422186
Drug level abnormal 19.61 12.15 10 151186 97 29423234
Transurethral prostatectomy 19.59 12.15 15 151181 312 29423019
Shock 19.50 12.15 51 151145 21353 29401978
Generalised oedema 19.49 12.15 17 151179 11148 29412183
Status epilepticus 19.38 12.15 16 151180 10778 29412553
Post procedural infection 19.26 12.15 57 151139 4248 29419083
Blister 19.25 12.15 46 151150 19860 29403471
Faeces discoloured 19.18 12.15 24 151172 13327 29410004
Hyperammonaemia 19.15 12.15 3 151193 5660 29417671
Pneumonitis 19.15 12.15 76 151120 27968 29395363
Wheezing 19.13 12.15 96 151100 33144 29390187
Drainage 19.07 12.15 5 151191 3 29423328
Thyroiditis subacute 19.04 12.15 7 151189 27 29423304
Neoplasm skin 19.01 12.15 19 151177 570 29422761
Muscle spasms 18.94 12.15 451 150745 64631 29358700
Gastroenteritis salmonella 18.89 12.15 16 151180 386 29422945
Polyuria 18.87 12.15 7 151189 7355 29415976
Laryngeal neoplasm 18.85 12.15 7 151189 28 29423303
Polychondritis 18.80 12.15 11 151185 143 29423188
Lymphopenia 18.74 12.15 25 151171 13508 29409823
Basosquamous carcinoma 18.71 12.15 9 151187 76 29423255
Cardiac failure acute 18.62 12.15 12 151184 9180 29414151
Hyperuricaemia 18.60 12.15 6 151190 6883 29416448
Blood triglycerides increased 18.51 12.15 23 151173 12811 29410520
Blood loss anaemia 18.47 12.15 7 151189 7259 29416072
Gallbladder operation 18.36 12.15 17 151179 463 29422868
Heart rate abnormal 18.36 12.15 31 151165 1578 29421753
Tricuspid valve incompetence 18.35 12.15 10 151186 8384 29414947
Nocturia 18.23 12.15 10 151186 8352 29414979
Neuroendocrine carcinoma of the skin 18.20 12.15 19 151177 601 29422730
Lewis-Sumner syndrome 18.11 12.15 7 151189 32 29423299
Liver injury 18.03 12.15 23 151173 12667 29410664
Intestinal tuberculosis 17.94 12.15 9 151187 84 29423247
Right ventricular failure 17.84 12.15 9 151187 7881 29415450
Respiratory distress 17.76 12.15 94 151102 32012 29391319
Anaphylactoid reaction 17.75 12.15 34 151162 1911 29421420
Elbow operation 17.71 12.15 10 151186 121 29423210
Hernia 17.60 12.15 87 151109 8271 29415060
Oesophagitis 17.58 12.15 21 151175 11902 29411429
Atrioventricular block first degree 17.58 12.15 3 151193 5316 29418015
Left ventricular dysfunction 17.52 12.15 12 151184 8890 29414441
Histone antibody positive 17.49 12.15 5 151191 6 29423325
Hypothermia 17.47 12.15 13 151183 9226 29414105
Lymphadenitis bacterial 17.46 12.15 6 151190 18 29423313
Cardiac murmur 17.44 12.15 6 151190 6607 29416724
Ventricular extrasystoles 17.42 12.15 17 151179 10565 29412766
Intestinal anastomosis 17.39 12.15 12 151184 211 29423120
Immunosuppression 17.35 12.15 63 151133 5223 29418108
Apathy 17.34 12.15 5 151191 6166 29417165
Anal ulcer 17.26 12.15 19 151177 639 29422692
Tonsillitis 17.14 12.15 34 151162 1961 29421370
Hepatic steatosis 17.13 12.15 133 151063 14813 29408518
Anal neoplasm 17.13 12.15 4 151192 0 29423331
Small intestine carcinoma metastatic 17.13 12.15 4 151192 0 29423331
Fistula inflammation 17.13 12.15 4 151192 0 29423331
Benign renal neoplasm 17.13 12.15 4 151192 0 29423331
Nasopharyngeal cancer 17.02 12.15 10 151186 131 29423200
Foreign body in eye 17.00 12.15 8 151188 64 29423267
Radial nerve palsy 17.00 12.15 8 151188 64 29423267
Enterocolonic fistula 16.99 12.15 9 151187 95 29423236
Lung cancer metastatic 16.94 12.15 38 151158 2389 29420942
Tooth extraction 16.90 12.15 53 151143 4076 29419255
Oesophageal fibrosis 16.88 12.15 11 151185 175 29423156
Toxic skin eruption 16.86 12.15 15 151181 9742 29413589
Wound infection 16.84 12.15 68 151128 5928 29417403
Tinnitus 16.81 12.15 34 151162 15580 29407751
Double stranded DNA antibody positive 16.72 12.15 11 151185 178 29423153
Sudden death 16.72 12.15 29 151167 14081 29409250
Multifocal motor neuropathy 16.70 12.15 7 151189 41 29423290
Perineal fistula 16.67 12.15 5 151191 8 29423323
Fine motor skill dysfunction 16.54 12.15 29 151167 1522 29421809
Bile duct cancer 16.50 12.15 18 151178 599 29422732
Hepatic function abnormal 16.37 12.15 287 150909 38972 29384359
Ear neoplasm 16.29 12.15 8 151188 71 29423260
Disseminated aspergillosis 16.28 12.15 15 151181 406 29422925
Cyst 16.24 12.15 51 151145 3926 29419405
Leishmaniasis 16.20 12.15 13 151183 290 29423041
Alopecia areata 16.16 12.15 11 151185 189 29423142
Dialysis 16.12 12.15 17 151179 10191 29413140
Oral pustule 16.11 12.15 12 151184 239 29423092
Postoperative wound infection 16.10 12.15 53 151143 4183 29419148
Herpes zoster oticus 16.07 12.15 9 151187 107 29423224
Arrhythmia 16.05 12.15 94 151102 31219 29392112
Ecchymosis 16.04 12.15 6 151190 6274 29417057
Rheumatoid factor 16.01 12.15 8 151188 74 29423257
Prescribed underdose 15.99 12.15 10 151186 7776 29415555
Sleep apnoea syndrome 15.98 12.15 42 151154 17557 29405774
Blood albumin decreased 15.80 12.15 22 151174 11673 29411658
Accidental exposure to product 15.79 12.15 19 151177 10734 29412597
Ocular hyperaemia 15.79 12.15 90 151106 9037 29414294
Neoplasm 15.76 12.15 52 151144 4109 29419222
Gastric ulcer haemorrhage 15.75 12.15 3 151193 4911 29418420
Dizziness postural 15.74 12.15 4 151192 5363 29417968
Demyelinating polyneuropathy 15.73 12.15 24 151172 1120 29422211
Atrioventricular block 15.73 12.15 8 151188 6974 29416357
Oral herpes 15.72 12.15 55 151141 4477 29418854
Blood pressure decreased 15.72 12.15 323 150873 45154 29378177
Anorectal disorder 15.68 12.15 22 151174 951 29422380
Gastric ulcer 15.68 12.15 30 151166 14031 29409300
Ileocolectomy 15.65 12.15 5 151191 11 29423320
Blood uric acid increased 15.62 12.15 5 151191 5763 29417568
Tympanic membrane perforation 15.61 12.15 12 151184 251 29423080
Decubitus ulcer 15.57 12.15 9 151187 7302 29416029
Abdominal discomfort 15.56 12.15 163 151033 47740 29375591
Intestinal adenocarcinoma 15.54 12.15 7 151189 50 29423281
Rash pustular 15.48 12.15 56 151140 4635 29418696
Viral infection 15.46 12.15 129 151067 14681 29408650
Thrombotic microangiopathy 15.42 12.15 13 151183 8668 29414663
Cardiovascular disorder 15.39 12.15 88 151108 8847 29414484
Loss of therapeutic response 15.37 12.15 13 151183 313 29423018
Lip neoplasm malignant stage unspecified 15.35 12.15 5 151191 12 29423319
Gastrointestinal dysplasia 15.35 12.15 5 151191 12 29423319
Dysuria 15.20 12.15 61 151135 22379 29400952
Arthrodesis 15.20 12.15 15 151181 443 29422888
Mycobacterial infection 15.19 12.15 31 151165 1825 29421506
Hyperthyroidism 15.16 12.15 13 151183 8595 29414736
Neurogenic shock 15.14 12.15 10 151186 163 29423168
Dyslipidaemia 15.14 12.15 6 151190 6055 29417276
Taste disorder 15.13 12.15 3 151193 4773 29418558
Hypoacusis 15.03 12.15 32 151164 14391 29408940
Shock haemorrhagic 14.98 12.15 16 151180 9535 29413796
Malignant respiratory tract neoplasm 14.90 12.15 4 151192 3 29423328
Staphylococcus test 14.90 12.15 4 151192 3 29423328
COVID-19 pneumonia 14.88 12.15 16 151180 9506 29413825
Cholecystectomy 14.85 12.15 36 151160 2381 29420950
Needle issue 14.71 12.15 3 151193 4680 29418651
Haemophagocytic lymphohistiocytosis 14.66 12.15 98 151098 10406 29412925
Immune reconstitution inflammatory syndrome associated tuberculosis 14.65 12.15 14 151182 397 29422934
Episcleritis 14.62 12.15 9 151187 129 29423202
Vision blurred 14.61 12.15 133 151063 40043 29383288
Aortic bruit 14.58 12.15 10 151186 174 29423157
Dental implantation 14.56 12.15 7 151189 59 29423272
Exposure to communicable disease 14.50 12.15 9 151187 131 29423200
Dermatitis acneiform 14.45 12.15 5 151191 5486 29417845
Narcotic bowel syndrome 14.44 12.15 9 151187 132 29423199
Hypercalcaemia 14.42 12.15 27 151169 12732 29410599
Granuloma 14.40 12.15 36 151160 2428 29420903
Wrist deformity 14.38 12.15 13 151183 343 29422988
Stoma creation 14.37 12.15 4 151192 4 29423327
Hypergammaglobulinaemia benign monoclonal 14.31 12.15 11 151185 230 29423101
Pharyngeal mass 14.31 12.15 5 151191 16 29423315
Steroid dependence 14.29 12.15 12 151184 286 29423045
Infective pulmonary exacerbation of cystic fibrosis 14.27 12.15 7 151189 6229 29417102
Vaccination complication 14.27 12.15 7 151189 62 29423269
Exposure to SARS-CoV-2 14.27 12.15 9 151187 135 29423196
Injection site pruritus 14.27 12.15 6 151190 5843 29417488
Glioma 14.19 12.15 12 151184 289 29423042
Drain placement 14.17 12.15 7 151189 63 29423268
Graft versus host disease 14.15 12.15 17 151179 9611 29413720
Sexual dysfunction 14.12 12.15 6 151190 5808 29417523
Pharyngeal neoplasm 14.09 12.15 5 151191 17 29423314
Hepatitis cholestatic 13.96 12.15 9 151187 6884 29416447
Infusion site oedema 13.93 12.15 9 151187 141 29423190
Blood lactic acid increased 13.93 12.15 6 151190 5760 29417571
Pseudopolyposis 13.93 12.15 6 151190 38 29423293
Upper limb fracture 13.91 12.15 49 151147 4002 29419329
Ileocaecal resection 13.91 12.15 4 151192 5 29423326
Visual acuity reduced 13.90 12.15 35 151161 14841 29408490
Circumcision 13.87 12.15 5 151191 18 29423313
Fear of injection 13.85 12.15 19 151177 804 29422527
Palpitations 13.83 12.15 239 150957 32365 29390966
Salmonella sepsis 13.82 12.15 9 151187 143 29423188
Skin infection 13.78 12.15 68 151128 6459 29416872
Visceral leishmaniasis 13.71 12.15 15 151181 501 29422830
Hepatitis acute 13.69 12.15 8 151188 6454 29416877
Bowen's disease 13.66 12.15 9 151187 146 29423185
Brain neoplasm benign 13.66 12.15 5 151191 19 29423312
Hemiparesis 13.60 12.15 34 151162 14452 29408879
Headache 13.58 12.15 1049 150147 172958 29250373
Varicella zoster pneumonia 13.54 12.15 7 151189 70 29423261
Pericardial effusion 13.53 12.15 59 151137 21149 29402182
Acute pulmonary oedema 13.53 12.15 9 151187 6770 29416561
Colon cancer metastatic 13.53 12.15 26 151170 1465 29421866
Anti-platelet antibody 13.49 12.15 4 151192 6 29423325
Coordination abnormal 13.46 12.15 10 151186 7104 29416227
Haemolytic anaemia 13.46 12.15 17 151179 9402 29413929
Gastrointestinal mucosa hyperaemia 13.39 12.15 11 151185 254 29423077
Bundle branch block right 13.29 12.15 9 151187 6708 29416623
Device occlusion 13.29 12.15 6 151190 5602 29417729
Amnesia 13.26 12.15 65 151131 22578 29400753
Retroperitoneal abscess 13.25 12.15 9 151187 154 29423177
Bone pain 13.25 12.15 49 151147 18403 29404928
Therapy partial responder 13.23 12.15 5 151191 5194 29418137
Limb discomfort 13.19 12.15 89 151107 9479 29413852
Sensitivity to weather change 13.19 12.15 25 151171 1394 29421937
Small cell lung cancer extensive stage 13.11 12.15 4 151192 7 29423324
Arthroscopic surgery 13.11 12.15 4 151192 7 29423324
Ligament operation 13.11 12.15 4 151192 7 29423324
Acute myeloid leukaemia 13.11 12.15 42 151154 16471 29406860
Rectal discharge 13.10 12.15 9 151187 157 29423174
Coronary artery aneurysm 13.05 12.15 7 151189 76 29423255
Axial spondyloarthritis 13.04 12.15 11 151185 264 29423067
Illness 13.02 12.15 68 151128 6606 29416725
Gastrointestinal obstruction 12.99 12.15 17 151179 687 29422644
Feeling cold 12.98 12.15 86 151110 9105 29414226
Electrocardiogram abnormal 12.96 12.15 11 151185 7311 29416020
Hypoxic-ischaemic encephalopathy 12.94 12.15 3 151193 4281 29419050
Hordeolum 12.94 12.15 18 151178 772 29422559
Bone tuberculosis 12.89 12.15 12 151184 329 29423002
Carcinoma in situ of skin 12.89 12.15 7 151189 78 29423253
Low birth weight baby 12.88 12.15 9 151187 6599 29416732
Duodenal ulcer 12.86 12.15 17 151179 9221 29414110
Precancerous cells present 12.86 12.15 6 151190 47 29423284
Intestinal transit time increased 12.84 12.15 3 151193 0 29423331
Aneurysmal bone cyst 12.84 12.15 3 151193 0 29423331
Lupus pleurisy 12.84 12.15 3 151193 0 29423331
Nephroblastoma 12.84 12.15 3 151193 0 29423331
Ear infection bacterial 12.84 12.15 3 151193 0 29423331
Biopsy skin 12.84 12.15 3 151193 0 29423331
Arthritis salmonella 12.84 12.15 3 151193 0 29423331
Malignant palate neoplasm 12.84 12.15 3 151193 0 29423331
Dientamoeba infection 12.84 12.15 3 151193 0 29423331
Malignant neoplasm of thorax 12.84 12.15 3 151193 0 29423331
Malignant melanoma of sites other than skin 12.84 12.15 3 151193 0 29423331
Hodgkin's disease stage IV 12.84 12.15 3 151193 0 29423331
Anal dilation procedure 12.84 12.15 3 151193 0 29423331
Jejunectomy 12.84 12.15 3 151193 0 29423331
Laryngitis viral 12.84 12.15 3 151193 0 29423331
Germ cell cancer 12.81 12.15 7 151189 79 29423252
Penile squamous cell carcinoma 12.81 12.15 7 151189 79 29423252
Small intestine adenocarcinoma 12.80 12.15 8 151188 118 29423213
Cyclic neutropenia 12.77 12.15 4 151192 8 29423323
Meningitis herpes 12.77 12.15 4 151192 8 29423323
Drug level increased 12.77 12.15 51 151145 18736 29404595
Tuberculosis liver 12.75 12.15 6 151190 48 29423283
Peripheral arterial occlusive disease 12.72 12.15 5 151191 5071 29418260
Superficial spreading melanoma stage unspecified 12.72 12.15 9 151187 165 29423166
Amyotrophic lateral sclerosis 12.69 12.15 19 151177 872 29422459
Groin abscess 12.69 12.15 15 151181 546 29422785
Abdominal operation 12.66 12.15 7 151189 81 29423250
Faeces soft 12.65 12.15 35 151161 2510 29420821
Gynaecomastia 12.63 12.15 14 151182 8203 29415128
Pruritus 12.61 12.15 724 150472 116125 29307206
Immune thrombocytopenia 12.57 12.15 13 151183 7864 29415467
Tubulointerstitial nephritis 12.57 12.15 47 151149 17596 29405735
Myocardial ischaemia 12.56 12.15 41 151155 15987 29407344
Pulmonary nocardiosis 12.56 12.15 15 151181 552 29422779
Colonic fistula 12.54 12.15 12 151184 341 29422990
Granuloma skin 12.51 12.15 16 151180 632 29422699
Skin plaque 12.49 12.15 45 151151 3717 29419614
Ankle operation 12.47 12.15 10 151186 223 29423108
Epstein Barr virus positive mucocutaneous ulcer 12.46 12.15 11 151185 281 29423050
Rectal fissure 12.46 12.15 11 151185 281 29423050
Suspected COVID-19 12.45 12.15 15 151181 557 29422774
Colonoscopy abnormal 12.44 12.15 6 151190 51 29423280
Gastritis erosive 12.42 12.15 6 151190 5387 29417944
Pulmonary function test decreased 12.41 12.15 3 151193 4160 29419171
Pertussis 12.40 12.15 9 151187 172 29423159
Infusion site pain 12.40 12.15 38 151158 2887 29420444
Obsessive-compulsive disorder 12.33 12.15 4 151192 4572 29418759
Gingival bleeding 12.30 12.15 9 151187 6444 29416887
Glomerulonephritis 12.30 12.15 27 151169 1673 29421658
Spondyloarthropathy 12.30 12.15 14 151182 489 29422842
Diffuse large B-cell lymphoma stage IV 12.28 12.15 10 151186 228 29423103
Appendicitis perforated 12.27 12.15 27 151169 1676 29421655
Tongue neoplasm 12.26 12.15 5 151191 27 29423304
Autoantibody positive 12.24 12.15 6 151190 53 29423278
Pulseless electrical activity 12.23 12.15 9 151187 6425 29416906
Deep vein thrombosis 12.22 12.15 382 150814 57017 29366314
Dysplastic naevus syndrome 12.17 12.15 4 151192 10 29423321
Anorectal stenosis 12.17 12.15 4 151192 10 29423321

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Infusion related reaction 6603.68 11.40 6314 368339 158153 63965926
Off label use 6274.18 11.40 12252 362401 620554 63503525
Product use issue 6074.73 11.40 5817 368836 145898 63978181
Intentional product use issue 3681.72 11.40 3588 371065 91776 64032303
Drug ineffective 3394.12 11.40 11611 363042 828636 63295443
Inappropriate schedule of product administration 2667.44 11.40 2975 371678 89311 64034768
Condition aggravated 2372.24 11.40 6066 368587 366360 63757719
Blood pressure fluctuation 2081.26 11.40 1995 372658 49876 64074203
Treatment failure 1771.42 11.40 2742 371911 114074 64010005
Toxicity to various agents 1762.20 11.40 84 374569 363429 63760650
Drug intolerance 1735.36 11.40 3550 371103 184442 63939637
Acute kidney injury 1589.64 11.40 337 374316 448903 63675176
Lupus-like syndrome 1541.78 11.40 832 373821 7959 64116120
Contraindicated product administered 1523.83 11.40 2451 372202 105378 64018701
Synovitis 1471.27 11.40 2304 372349 96786 64027293
Drug interaction 1382.29 11.40 224 374429 361859 63762220
Death 1366.47 11.40 549 374104 482156 63641923
Therapeutic product effect decreased 1296.69 11.40 2369 372284 112982 64011097
Intestinal resection 1276.02 11.40 527 374126 2541 64121538
Joint swelling 1258.49 11.40 3402 371251 211980 63912099
Systemic lupus erythematosus 1209.73 11.40 1846 372807 75766 64048313
Drug level below therapeutic 1165.72 11.40 652 374001 6732 64117347
Completed suicide 1119.40 11.40 42 374611 224372 63899707
Arthropathy 1096.72 11.40 2269 372384 118698 64005381
Arthralgia 1035.87 11.40 5187 369466 437073 63687006
Drug specific antibody present 1034.87 11.40 534 374119 4620 64119459
Frequent bowel movements 999.09 11.40 838 373815 17467 64106612
Skin cancer 972.54 11.40 694 373959 11280 64112799
Tuberculosis 932.95 11.40 700 373953 12338 64111741
Alopecia 901.46 11.40 2551 372102 163139 63960940
Haematochezia 879.16 11.40 1466 373187 64907 64059172
Disseminated tuberculosis 862.14 11.40 422 374231 3223 64120856
Febrile neutropenia 834.77 11.40 68 374585 187589 63936490
Pemphigus 831.20 11.40 1361 373292 59340 64064739
Pulmonary tuberculosis 824.79 11.40 518 374135 6726 64117353
Hand deformity 792.28 11.40 1357 373296 61414 64062665
Neutropenia 756.88 11.40 226 374427 239398 63884681
Anaemia 751.93 11.40 657 373996 378023 63746056
Anti-cyclic citrullinated peptide antibody positive 727.41 11.40 1147 373506 48415 64075664
Drug abuse 725.17 11.40 8 374645 132366 63991713
Fall 697.45 11.40 838 373815 415988 63708091
Fistula 691.57 11.40 521 374132 9240 64114839
Hypersensitivity 682.59 11.40 2597 372056 193855 63930224
Rheumatoid arthritis 676.43 11.40 2296 372357 161998 63962081
Pericarditis 670.52 11.40 1259 373394 61257 64062822
Glossodynia 666.84 11.40 1281 373372 63415 64060664
Therapeutic response shortened 627.24 11.40 500 374153 9670 64114409
Rheumatoid factor positive 596.97 11.40 868 373785 34070 64090009
Hyponatraemia 594.71 11.40 79 374574 148260 63975819
Drug level decreased 583.49 11.40 505 374148 10998 64113081
Hypotension 576.51 11.40 825 373828 380149 63743930
Cardiac arrest 572.23 11.40 102 374551 153962 63970117
Heart rate decreased 562.13 11.40 1086 373567 53981 64070098
Psoriasis 557.80 11.40 1265 373388 70438 64053641
Transplant dysfunction 547.49 11.40 390 374263 6318 64117761
Therapeutic product effect incomplete 540.64 11.40 1571 373082 101911 64022168
Faecal calprotectin increased 535.63 11.40 307 374346 3333 64120746
Thrombocytopenia 520.19 11.40 329 374324 223472 63900607
Platelet count decreased 517.07 11.40 165 374488 167546 63956533
Anal abscess 512.58 11.40 392 374261 7116 64116963
Heart rate irregular 508.02 11.40 708 373945 26705 64097374
C-reactive protein abnormal 501.12 11.40 725 373928 28322 64095757
Basal cell carcinoma 497.82 11.40 746 373907 30092 64093987
Hyperkalaemia 496.90 11.40 21 374632 101108 64022971
Ovarian cyst 495.77 11.40 452 374201 10566 64113513
Anal fistula 488.73 11.40 331 374322 4922 64119157
Wound 488.29 11.40 1250 373403 75227 64048852
Red blood cell sedimentation rate increased 483.52 11.40 741 373912 30494 64093585
Overdose 483.09 11.40 162 374491 159404 63964675
Malignant neoplasm progression 482.64 11.40 48 374605 112823 64011256
White blood cell count decreased 473.06 11.40 163 374490 157674 63966405
Somnolence 469.63 11.40 302 374351 203343 63920736
Weight increased 465.19 11.40 2456 372197 210892 63913187
Disease progression 455.57 11.40 129 374524 141551 63982528
Colectomy 449.85 11.40 245 374408 2389 64121690
Acne 442.53 11.40 606 374047 22475 64101604
Flushing 439.93 11.40 1224 373429 77424 64046655
Swelling 428.17 11.40 1955 372698 158263 63965816
Intentional overdose 427.96 11.40 23 374630 89921 64034158
Abdominal discomfort 423.14 11.40 2136 372517 180186 63943893
Poor venous access 410.00 11.40 430 374223 11987 64112092
Hypoglycaemia 409.65 11.40 29 374624 89863 64034216
Cardiac failure congestive 403.28 11.40 128 374525 130452 63993627
Electrocardiogram QT prolonged 402.35 11.40 13 374640 79435 64044644
Atrial fibrillation 402.30 11.40 248 374405 170841 63953238
Cardio-respiratory arrest 400.08 11.40 50 374603 98343 64025736
Pancytopenia 392.97 11.40 170 374483 143139 63980940
Discomfort 392.09 11.40 1196 373457 79682 64044397
Intestinal stenosis 391.64 11.40 240 374413 2974 64121105
Rhabdomyolysis 389.56 11.40 40 374613 91686 64032393
Seizure 369.25 11.40 259 374394 166633 63957446
Asthenia 369.23 11.40 1264 373389 426780 63697299
Sleep disorder due to general medical condition, insomnia type 366.16 11.40 594 374059 25676 64098403
Blood creatinine increased 364.54 11.40 166 374487 135616 63988463
Hepatic enzyme increased 363.90 11.40 1608 373045 128335 63995744
Anal fissure 361.99 11.40 269 374384 4667 64119412
Cardiac failure 359.82 11.40 159 374494 132214 63991865
Bradycardia 359.55 11.40 119 374534 118100 64005979
Gastrointestinal haemorrhage 357.96 11.40 160 374493 132152 63991927
Helicobacter infection 355.85 11.40 727 373926 37635 64086444
Musculoskeletal stiffness 352.12 11.40 1534 373119 121672 64002407
Loss of personal independence in daily activities 349.85 11.40 1070 373583 71384 64052695
Arthritis 339.83 11.40 1166 373487 82648 64041431
Clostridium difficile infection 338.61 11.40 688 373965 35475 64088604
Duodenal ulcer perforation 336.46 11.40 669 373984 33956 64090123
Body temperature fluctuation 336.22 11.40 220 374433 3078 64121001
International normalised ratio increased 332.39 11.40 36 374617 79131 64044948
Oedema peripheral 327.06 11.40 446 374207 209871 63914208
Constipation 322.91 11.40 521 374132 228816 63895263
Incorrect dose administered 321.50 11.40 927 373726 59838 64064241
Hallucination 319.00 11.40 28 374625 72760 64051319
Coma 318.79 11.40 61 374592 87554 64036525
Drug hypersensitivity 312.94 11.40 2408 372245 235407 63888672
Hypokalaemia 312.01 11.40 159 374494 121744 64002335
Neutrophil count decreased 311.96 11.40 40 374613 77156 64046923
Herpes zoster 310.05 11.40 1089 373564 78098 64045981
Bone erosion 305.87 11.40 357 374296 11238 64112841
Confusional state 305.32 11.40 664 373989 260480 63863599
Histoplasmosis disseminated 303.35 11.40 172 374481 1826 64122253
Uveitis 300.34 11.40 370 374283 12338 64111741
C-reactive protein increased 295.43 11.40 1213 373440 93696 64030383
Metabolic acidosis 293.53 11.40 34 374619 70924 64053155
Red blood cell sedimentation rate abnormal 292.97 11.40 415 374238 15891 64108188
Breast cancer 285.39 11.40 565 374088 28583 64095496
Exposure during pregnancy 282.66 11.40 1043 373610 76632 64047447
Maternal exposure during pregnancy 282.47 11.40 1205 373448 94679 64029400
Drug specific antibody 277.36 11.40 165 374488 1930 64122149
Lactic acidosis 276.38 11.40 21 374632 61389 64062690
Inflammation 272.19 11.40 917 373736 64383 64059696
Depressed level of consciousness 271.43 11.40 69 374584 81367 64042712
Dehydration 271.22 11.40 530 374123 216233 63907846
Hyperglycaemia 271.16 11.40 22 374631 60946 64063133
Psoriatic arthropathy 270.54 11.40 702 373951 42579 64081500
Lymphoma 270.20 11.40 368 374285 13573 64110506
Abscess 265.64 11.40 434 374219 18870 64105209
Blood glucose increased 261.48 11.40 121 374532 97952 64026127
Renal failure 261.13 11.40 407 374246 181281 63942798
Transplant rejection 259.73 11.40 406 374247 16995 64107084
Pyoderma gangrenosum 258.42 11.40 183 374470 2935 64121144
Urticaria 255.26 11.40 1596 373057 145721 63978358
Blood pressure increased 252.93 11.40 1793 372860 170759 63953320
Neuropathy peripheral 252.56 11.40 188 374465 117337 64006742
Drug level above therapeutic 249.59 11.40 251 374402 6650 64117429
Respiratory failure 249.30 11.40 343 374310 160840 63963239
Agitation 246.70 11.40 102 374551 88265 64035814
Lymph node tuberculosis 242.12 11.40 116 374537 840 64123239
Dizziness 241.82 11.40 1486 373167 428677 63695402
Ileal stenosis 239.28 11.40 150 374503 1940 64122139
Diarrhoea 235.86 11.40 2878 371775 719826 63404253
Balance disorder 235.71 11.40 96 374557 83830 64040249
Decreased appetite 233.22 11.40 844 373809 280445 63843634
Pneumonia legionella 232.02 11.40 156 374497 2290 64121789
Mental status changes 230.24 11.40 39 374614 61123 64062956
Therapeutic response decreased 230.10 11.40 747 373906 51441 64072638
Respiratory arrest 227.84 11.40 22 374631 52963 64071116
Drug reaction with eosinophilia and systemic symptoms 226.71 11.40 25 374628 54192 64069887
Renal impairment 225.65 11.40 271 374382 134746 63989333
Sedation 224.76 11.40 3 374650 41459 64082620
Histoplasmosis 223.69 11.40 142 374511 1880 64122199
Intentional product misuse 221.13 11.40 72 374581 72223 64051856
Pain 217.54 11.40 4462 370191 549049 63575030
Injection site pain 216.10 11.40 197 374456 111211 64012868
Acute myocardial infarction 215.79 11.40 68 374585 69650 64054429
Colitis ulcerative 215.42 11.40 438 374215 22590 64101489
Disorientation 213.72 11.40 34 374619 55794 64068285
Delirium 213.26 11.40 68 374585 69126 64054953
Hypoxia 212.39 11.40 124 374529 88025 64036054
Multiple sclerosis relapse 210.91 11.40 6 374647 41129 64082950
Mucous stools 210.59 11.40 165 374488 3108 64120971
Haemoglobin decreased 209.34 11.40 519 374134 194544 63929535
Folliculitis 209.08 11.40 508 374145 29569 64094510
Irritable bowel syndrome 208.27 11.40 581 374072 36788 64087291
Mucosal inflammation 206.69 11.40 54 374599 62530 64061549
Suicide attempt 203.04 11.40 79 374574 70928 64053151
Pneumonia aspiration 201.83 11.40 48 374605 59223 64064856
Blood parathyroid hormone decreased 201.34 11.40 231 374422 7135 64116944
Disability 200.04 11.40 297 374356 11875 64112204
Large intestinal stenosis 199.59 11.40 142 374511 2295 64121784
Granuloma skin 198.13 11.40 209 374444 5865 64118214
Panniculitis 197.81 11.40 251 374402 8628 64115451
Pulmonary oedema 197.73 11.40 105 374548 78569 64045510
Encephalopathy 197.62 11.40 49 374604 58770 64065309
Knee arthroplasty 190.87 11.40 459 374194 26540 64097539
Dysarthria 187.35 11.40 56 374597 59350 64064729
Injection site erythema 186.17 11.40 89 374564 70711 64053368
Product dose omission issue 185.77 11.40 549 374104 194198 63929881
Hepatosplenic T-cell lymphoma 184.96 11.40 92 374561 730 64123349
Neoplasm progression 184.35 11.40 14 374639 40950 64083129
Fluid retention 181.18 11.40 60 374593 59546 64064533
Cerebrovascular accident 181.16 11.40 326 374327 137257 63986822
Peritoneal tuberculosis 180.68 11.40 78 374575 428 64123651
Muscle injury 178.95 11.40 442 374211 25995 64098084
Hypervolaemia 178.37 11.40 11 374642 38274 64085805
Blood bilirubin increased 178.36 11.40 56 374597 57497 64066582
Coronary artery disease 178.22 11.40 64 374589 60369 64063710
Infection 178.09 11.40 1748 372905 183132 63940947
Neoplasm malignant 178.07 11.40 423 374230 24265 64099814
Memory impairment 177.78 11.40 142 374511 85540 64038539
Enthesopathy 177.15 11.40 248 374405 9390 64114689
Cognitive disorder 175.42 11.40 51 374602 55036 64069043
Malignant melanoma 175.04 11.40 289 374364 12675 64111404
Orthostatic hypotension 173.30 11.40 31 374622 46707 64077372
Blood creatine phosphokinase increased 172.71 11.40 62 374591 58496 64065583
Chest discomfort 172.07 11.40 1210 373443 114896 64009183
Tenosynovitis 170.94 11.40 272 374381 11561 64112518
Rheumatoid nodule 168.10 11.40 280 374373 12371 64111708
Pulmonary hypertension 168.03 11.40 25 374628 43114 64080965
Unresponsive to stimuli 165.42 11.40 44 374609 50349 64073730
Urinary retention 165.26 11.40 41 374612 49160 64074919
Accidental overdose 164.68 11.40 7 374646 33550 64090529
Abdominal pain 164.58 11.40 2638 372015 309737 63814342
Drug tolerance decreased 162.55 11.40 202 374451 6796 64117283
Aggression 162.30 11.40 35 374618 46197 64077882
Blood urea increased 162.17 11.40 30 374623 44123 64079956
Hypomagnesaemia 162.08 11.40 15 374638 37361 64086718
Toxic epidermal necrolysis 160.94 11.40 15 374638 37151 64086928
Altered state of consciousness 159.68 11.40 17 374636 37885 64086194
Lymphoproliferative disorder 156.59 11.40 170 374483 4933 64119146
Ascites 155.43 11.40 83 374570 61918 64062161
Hip arthroplasty 154.18 11.40 366 374287 20985 64103094
Dysphagia 151.73 11.40 241 374412 106571 64017508
Gastrointestinal disorder 150.99 11.40 965 373688 88744 64035335
Melaena 150.75 11.40 61 374592 53487 64070592
Dyspnoea exertional 148.24 11.40 126 374527 73604 64050475
Palmar-plantar erythrodysaesthesia syndrome 144.88 11.40 5 374648 28814 64095265
Demyelination 144.10 11.40 188 374465 6646 64117433
Drug eruption 143.13 11.40 499 374154 35637 64088442
Cerebral haemorrhage 142.53 11.40 59 374594 51031 64073048
Leukopenia 142.33 11.40 230 374423 101012 64023067
Syncope 142.04 11.40 456 374197 157179 63966900
Pustular psoriasis 141.93 11.40 147 374506 4036 64120043
Ankylosing spondylitis 141.22 11.40 205 374448 8029 64116050
Wrong technique in product usage process 140.76 11.40 103 374550 64871 64059208
Mycobacterium marinum infection 140.23 11.40 61 374592 342 64123737
Plasma cell myeloma 138.95 11.40 47 374606 46028 64078051
Pouchitis 138.93 11.40 76 374577 748 64123331
Blood alkaline phosphatase increased 138.66 11.40 77 374576 56202 64067877
Dysgeusia 136.74 11.40 51 374602 46996 64077083
Rheumatic fever 136.13 11.40 215 374438 9079 64115000
Lethargy 135.32 11.40 133 374520 72461 64051618
Intestinal obstruction 135.10 11.40 491 374162 35795 64088284
Meningitis listeria 134.62 11.40 73 374580 705 64123374
Multiple organ dysfunction syndrome 132.84 11.40 241 374412 101172 64022907
Chronic obstructive pulmonary disease 132.63 11.40 130 374523 70918 64053161
Agranulocytosis 132.06 11.40 30 374623 38199 64085880
Insomnia 131.99 11.40 645 374008 197191 63926888
Dyskinesia 131.95 11.40 33 374620 39355 64084724
Diarrhoea haemorrhagic 131.50 11.40 235 374418 10992 64113087
Erythema nodosum 131.00 11.40 138 374515 3866 64120213
Ileostomy 130.54 11.40 84 374569 1140 64122939
Polyarthritis 130.39 11.40 216 374437 9499 64114580
Vomiting 129.87 11.40 2337 372316 548780 63575299
Upper gastrointestinal haemorrhage 129.20 11.40 24 374629 35196 64088883
Hypophagia 129.11 11.40 35 374618 39552 64084527
Product quality issue 129.10 11.40 12 374641 29787 64094292
Myocardial infarction 128.56 11.40 511 374142 165310 63958769
Haematoma 128.07 11.40 54 374599 46196 64077883
Bone marrow failure 128.03 11.40 59 374594 47893 64076186
Hepatic failure 127.74 11.40 82 374571 55312 64068767
Intentional self-injury 127.71 11.40 11 374642 29033 64095046
Infusion site extravasation 127.26 11.40 177 374476 6660 64117419
Drug withdrawal syndrome 126.92 11.40 16 374637 31275 64092804
Apparent death 126.72 11.40 113 374540 2563 64121516
Ventricular tachycardia 126.44 11.40 23 374630 34242 64089837
Haemoptysis 123.91 11.40 65 374588 48983 64075096
Haematuria 121.98 11.40 103 374550 60368 64063711
Neurotoxicity 121.54 11.40 10 374643 27394 64096685
Adverse event 121.44 11.40 503 374150 38986 64085093
Full blood count abnormal 121.22 11.40 15 374638 29742 64094337
B-cell lymphoma 119.57 11.40 153 374500 5304 64118775
Rash maculo-papular 119.28 11.40 62 374591 46964 64077115
Serum sickness 119.03 11.40 118 374535 3071 64121008
Urinary tract infection 118.71 11.40 822 373831 230774 63893305
Jaundice 118.61 11.40 67 374586 48445 64075634
Tuberculous pleurisy 118.16 11.40 61 374592 528 64123551
Squamous cell carcinoma 117.13 11.40 253 374400 13616 64110463
Subdural haematoma 117.12 11.40 13 374640 28041 64096038
Diabetic ketoacidosis 116.92 11.40 17 374636 29828 64094251
Full blood count decreased 116.86 11.40 3 374650 22579 64101500
Lymphocyte count decreased 116.81 11.40 45 374608 40654 64083425
Antinuclear antibody positive 116.62 11.40 162 374491 6088 64117991
Irritability 115.21 11.40 35 374618 36711 64087368
Gastrooesophageal reflux disease 114.89 11.40 191 374462 82952 64041127
Stevens-Johnson syndrome 114.14 11.40 29 374624 34220 64089859
Impaired healing 114.04 11.40 670 373983 59803 64064276
Salmonellosis 113.98 11.40 80 374573 1264 64122815
Haematemesis 113.35 11.40 66 374587 46933 64077146
Gamma-glutamyltransferase increased 112.97 11.40 71 374582 48439 64075640
Rash 112.48 11.40 3471 371182 455078 63669001
Defaecation urgency 112.25 11.40 127 374526 3862 64120217
Myoclonus 111.86 11.40 9 374644 25109 64098970
Vision blurred 111.82 11.40 222 374431 90094 64033985
Cardiogenic shock 110.91 11.40 26 374627 32401 64091678
Pulmonary arterial hypertension 110.47 11.40 10 374643 25357 64098722
Acute respiratory failure 109.67 11.40 78 374575 49856 64074223
Body temperature decreased 109.66 11.40 366 374287 25562 64098517
Poisoning 109.27 11.40 4 374649 21875 64102204
Therapy cessation 109.25 11.40 27 374626 32462 64091617
Physical disability 109.21 11.40 97 374556 2188 64121891
Blood calcium decreased 108.84 11.40 11 374642 25543 64098536
Hallucination, visual 108.70 11.40 16 374637 27818 64096261
Withdrawal syndrome 108.69 11.40 7 374646 23485 64100594
Pleural effusion 108.56 11.40 374 374279 126185 63997894
Vein rupture 108.49 11.40 82 374571 1461 64122618
Nephrolithiasis 108.38 11.40 522 374131 43161 64080918
Hodgkin's disease 108.12 11.40 65 374588 776 64123303
Osteonecrosis of jaw 107.89 11.40 48 374605 39777 64084302
Peripheral swelling 106.16 11.40 1756 372897 207397 63916682
Throat tightness 106.13 11.40 336 374317 22824 64101255
Dry mouth 105.50 11.40 117 374536 60301 64063778
Erythema 105.28 11.40 1598 373055 185472 63938607
Anxiety 104.95 11.40 717 373936 201932 63922147
Mobility decreased 104.86 11.40 855 373798 84985 64039094
Depression 103.84 11.40 631 374022 182660 63941419
Blood potassium increased 103.65 11.40 14 374639 25966 64098113
Cutaneous leishmaniasis 103.05 11.40 45 374608 255 64123824
Ill-defined disorder 102.59 11.40 517 374136 43535 64080544
Sinus bradycardia 102.51 11.40 8 374645 22885 64101194
Therapy non-responder 101.84 11.40 694 373959 65205 64058874
Gastrointestinal inflammation 101.56 11.40 151 374502 6044 64118035
Rectal abscess 101.27 11.40 79 374574 1478 64122601
Musculoskeletal deformity 101.18 11.40 57 374596 597 64123482
Listeriosis 100.93 11.40 87 374566 1883 64122196
Labelled drug-drug interaction medication error 100.82 11.40 7 374646 22055 64102024
Cytokine release syndrome 100.08 11.40 5 374648 20824 64103255
Human antichimeric antibody positive 99.00 11.40 75 374578 1341 64122738
Disturbance in attention 98.60 11.40 58 374595 41016 64083063
Eosinophilia 98.36 11.40 49 374604 38027 64086052
Swollen joint count increased 97.93 11.40 167 374486 7522 64116557
Loss of consciousness 97.60 11.40 486 374167 147879 63976200
Cardiac disorder 97.56 11.40 108 374545 55708 64068371
Abnormal behaviour 96.78 11.40 37 374616 33585 64090494
Contrast media allergy 96.63 11.40 88 374565 2053 64122026
Neutropenic sepsis 96.61 11.40 11 374642 23261 64100818
Hepatocellular injury 95.03 11.40 74 374579 45161 64078918
Henoch-Schonlein purpura 94.38 11.40 88 374565 2118 64121961
Small intestinal resection 94.35 11.40 57 374596 687 64123392
Joint destruction 94.31 11.40 111 374542 3525 64120554
Blood potassium decreased 94.25 11.40 59 374594 40340 64083739
Pneumonia 93.89 11.40 2504 372149 557072 63567007
Pulmonary embolism 93.67 11.40 484 374169 145872 63978207
Aphasia 92.36 11.40 62 374591 40844 64083235
Muscular weakness 92.09 11.40 403 374250 126935 63997144
Sinus tachycardia 91.69 11.40 36 374617 32152 64091927
Lower respiratory tract infection 90.71 11.40 894 373759 93720 64030359
Ischaemic stroke 90.40 11.40 28 374625 29007 64095072
Sepsis 90.39 11.40 878 373775 229463 63894616
Respiratory depression 90.35 11.40 14 374639 23429 64100650
Ventricular fibrillation 90.26 11.40 15 374638 23845 64100234
Bone pain 90.00 11.40 86 374567 47486 64076593
Speech disorder 89.98 11.40 89 374564 48352 64075727
Therapy interrupted 89.72 11.40 7 374646 20029 64104050
Non-Hodgkin's lymphoma 89.58 11.40 72 374581 1409 64122670
Incorrect drug administration rate 89.47 11.40 94 374559 2625 64121454
Generalised tonic-clonic seizure 89.20 11.40 61 374592 39796 64084283
Ulcer 88.91 11.40 315 374338 22675 64101404
Injection site pruritus 88.58 11.40 55 374598 37771 64086308
Colectomy total 88.33 11.40 37 374616 186 64123893
Rheumatoid factor negative 87.93 11.40 63 374590 1030 64123049
Nasopharyngitis 87.92 11.40 1614 373039 194459 63929620
Torsade de pointes 87.32 11.40 3 374650 17360 64106719
Product administration error 87.26 11.40 26 374627 27617 64096462
Suicidal ideation 87.25 11.40 158 374495 66384 64057695
Extrapulmonary tuberculosis 87.22 11.40 43 374610 334 64123745
Coagulopathy 87.21 11.40 38 374615 31882 64092197
Extrapyramidal disorder 87.08 11.40 7 374646 19545 64104534
Nightmare 86.95 11.40 10 374643 20983 64103096
Ileectomy 86.74 11.40 34 374619 139 64123940
Hypothyroidism 86.50 11.40 65 374588 40392 64083687
Cerebral infarction 86.41 11.40 67 374586 40977 64083102
Device issue 86.21 11.40 14 374639 22634 64101445
Cholestasis 86.20 11.40 80 374573 44792 64079287
Urinary incontinence 85.44 11.40 52 374601 36099 64087980
Body height below normal 84.56 11.40 76 374577 1742 64122337
Psychotic disorder 84.18 11.40 48 374605 34530 64089549
Skin necrosis 84.01 11.40 227 374426 14102 64109977
Haemorrhage intracranial 84.00 11.40 18 374635 23866 64100213
Anuria 83.88 11.40 7 374646 18957 64105122
Proctectomy 83.68 11.40 28 374625 63 64124016
Fistula discharge 83.59 11.40 59 374594 941 64123138
Surgical failure 83.16 11.40 54 374599 745 64123334
Device dislocation 83.10 11.40 12 374641 21166 64102913
Chronic kidney disease 82.88 11.40 130 374523 57789 64066290
Anal stenosis 82.87 11.40 40 374613 295 64123784
Arthrodesis 81.85 11.40 79 374574 1988 64122091
Hallucination, auditory 81.60 11.40 4 374649 16935 64107144
Oedema 81.34 11.40 268 374385 91667 64032412
Tumour lysis syndrome 81.17 11.40 9 374644 19431 64104648
Vascular access complication 80.87 11.40 60 374593 1038 64123041
Blood sodium decreased 80.70 11.40 35 374618 29447 64094632
Anaphylactic reaction 80.68 11.40 678 373975 67986 64056093
Weight fluctuation 80.40 11.40 160 374493 8122 64115957
Legionella infection 80.35 11.40 51 374602 675 64123404
Myelosuppression 79.75 11.40 20 374633 23810 64100269
Intestinal fistula 79.16 11.40 62 374591 1167 64122912
Pseudopolyp 78.73 11.40 41 374612 362 64123717
Tuberculin test positive 78.49 11.40 93 374560 2975 64121104
Oxygen saturation abnormal 78.05 11.40 100 374553 3471 64120608
Hepatic encephalopathy 78.03 11.40 14 374639 21052 64103027
Right ventricular failure 77.96 11.40 15 374638 21456 64102623
Cholangitis sclerosing 77.23 11.40 74 374579 1845 64122234
Asthma 76.62 11.40 289 374364 94936 64029143
Circulatory collapse 76.32 11.40 51 374602 33681 64090398
Delusion 76.08 11.40 8 374645 18006 64106073
Mammoplasty 75.73 11.40 34 374619 208 64123871
Infusion site reaction 75.67 11.40 76 374577 2010 64122069
Restlessness 75.17 11.40 72 374581 39713 64084366
Haematocrit decreased 75.08 11.40 126 374527 54529 64069550
Renal tubular necrosis 75.08 11.40 18 374635 22092 64101987
Product use in unapproved indication 75.07 11.40 1442 373211 175176 63948903
Brain oedema 74.90 11.40 18 374635 22057 64102022
Obstructive airways disorder 74.67 11.40 21 374632 23164 64100915
Type IV hypersensitivity reaction 73.49 11.40 95 374558 3327 64120752
Transient ischaemic attack 73.42 11.40 89 374564 44093 64079986
Acute hepatic failure 73.08 11.40 30 374623 26082 64097997
Mydriasis 72.55 11.40 4 374649 15308 64108771
Weight decreased 72.32 11.40 2172 372481 283567 63840512
Rectal stenosis 72.19 11.40 35 374618 261 64123818
Inappropriate antidiuretic hormone secretion 72.13 11.40 20 374633 22269 64101810
Dermatitis psoriasiform 72.06 11.40 75 374578 2071 64122008
Red blood cell sedimentation rate 71.91 11.40 98 374555 3616 64120463
Sciatica 71.90 11.40 270 374383 19994 64104085
Feeling hot 71.80 11.40 483 374170 45180 64078899
Hypocalcaemia 71.64 11.40 82 374571 41671 64082408
Pneumocystis jirovecii pneumonia 71.29 11.40 334 374319 27300 64096779
Atlantoaxial instability 71.19 11.40 35 374618 270 64123809
Diabetes mellitus inadequate control 71.15 11.40 18 374635 21303 64102776
Urine output decreased 70.49 11.40 7 374646 16485 64107594
Mineral metabolism disorder 70.33 11.40 35 374618 278 64123801
Arrhythmia 70.05 11.40 125 374528 52819 64071260
Cardiomegaly 69.96 11.40 25 374628 23659 64100420
Lung neoplasm malignant 69.75 11.40 278 374375 21170 64102909
Ejection fraction decreased 69.67 11.40 40 374613 28667 64095412
Stomatitis 69.43 11.40 956 373697 108649 64015430
Atrial flutter 69.40 11.40 14 374639 19366 64104713
Status epilepticus 69.06 11.40 20 374633 21643 64102436
Contraindication to vaccination 69.00 11.40 31 374622 190 64123889
Depressed mood 68.81 11.40 82 374571 40930 64083149
Hyperbilirubinaemia 68.67 11.40 19 374634 21186 64102893
Oliguria 68.47 11.40 4 374649 14572 64109507
Emotional distress 68.34 11.40 65 374588 35973 64088106
Leukocytosis 68.20 11.40 71 374582 37669 64086410
Tremor 67.83 11.40 543 374110 147687 63976392
Tuberculosis gastrointestinal 67.52 11.40 40 374613 464 64123615
Shock 66.82 11.40 74 374579 38166 64085913
Epilepsy 66.54 11.40 58 374595 33473 64090606
Anal cancer 66.30 11.40 43 374610 592 64123487
Bronchitis chronic 66.13 11.40 97 374556 3835 64120244
Deep vein thrombosis 66.07 11.40 350 374303 104832 64019247
Sinusitis 65.65 11.40 1202 373451 144726 63979353
Fear 65.46 11.40 18 374635 20153 64103926
Cytopenia 65.01 11.40 7 374646 15464 64108615
Hyperlipidaemia 64.95 11.40 26 374627 22950 64101129
Spinal instability 64.90 11.40 35 374618 334 64123745
Parkinsonism 64.42 11.40 5 374648 14368 64109711
Sensitivity to weather change 64.33 11.40 129 374524 6585 64117494
Muscle spasticity 64.13 11.40 10 374643 16659 64107420
Injection site bruising 63.98 11.40 70 374583 36303 64087776
Inflammatory bowel disease 63.75 11.40 103 374550 4435 64119644
T-cell lymphoma 63.69 11.40 54 374599 1142 64122937
Tricuspid valve incompetence 63.63 11.40 11 374642 16992 64107087
Electrolyte imbalance 62.95 11.40 34 374619 25209 64098870
Pulmonary fibrosis 62.90 11.40 341 374312 29537 64094542
Dystonia 62.81 11.40 16 374637 18849 64105230
Subarachnoid haemorrhage 62.63 11.40 15 374638 18423 64105656
Clear cell renal cell carcinoma 62.38 11.40 70 374583 2109 64121970
Troponin increased 62.14 11.40 8 374645 15391 64108688
Perirectal abscess 62.03 11.40 64 374589 1749 64122330
Antibody test positive 61.64 11.40 73 374580 2334 64121745
Pericarditis tuberculous 61.31 11.40 23 374630 81 64123998
Miosis 61.23 11.40 4 374649 13262 64110817
Subcutaneous abscess 61.09 11.40 130 374523 6923 64117156
DNA antibody positive 60.87 11.40 31 374622 260 64123819
Ataxia 60.79 11.40 26 374627 22058 64102021
Dysuria 60.55 11.40 94 374559 41963 64082116
Faecal calprotectin abnormal 60.44 11.40 25 374628 121 64123958
Mania 59.94 11.40 11 374642 16275 64107804
Red blood cell count decreased 59.82 11.40 119 374534 48267 64075812
Fine motor skill dysfunction 59.77 11.40 102 374551 4597 64119482
Cutaneous T-cell lymphoma 59.68 11.40 71 374582 2281 64121798
Accidental exposure to product 59.46 11.40 40 374613 26324 64097755
Enterostomy 59.23 11.40 28 374625 196 64123883
Left ventricular dysfunction 59.17 11.40 13 374640 16941 64107138
Abdominal abscess 59.06 11.40 120 374533 6184 64117895
Dialysis 59.00 11.40 13 374640 16907 64107172
Infectious mononucleosis 58.97 11.40 61 374592 1672 64122407
Glomerular filtration rate decreased 58.95 11.40 20 374633 19552 64104527
X-ray abnormal 58.94 11.40 57 374596 1438 64122641
Hypothermia 58.58 11.40 21 374632 19835 64104244
Hypernatraemia 58.32 11.40 3 374650 12186 64111893
Medication error 58.31 11.40 127 374526 49839 64074240
Varicella 58.24 11.40 74 374579 2547 64121532
Treatment noncompliance 58.12 11.40 102 374551 43380 64080699
Joint stiffness 58.04 11.40 338 374315 30066 64094013
Alanine aminotransferase increased 57.90 11.40 522 374131 138509 63985570
Haemodialysis 57.79 11.40 14 374639 17063 64107016
Femur fracture 57.53 11.40 68 374585 34067 64090012
Acidosis 57.53 11.40 16 374637 17779 64106300
Hemiparesis 57.50 11.40 53 374600 29774 64094305
Alanine aminotransferase abnormal 57.42 11.40 125 374528 6763 64117316
Intestinal operation 57.13 11.40 34 374619 398 64123681
Diffuse large B-cell lymphoma 56.64 11.40 160 374493 10201 64113878
Angina pectoris 56.49 11.40 110 374543 44971 64079108
Oropharyngeal pain 56.23 11.40 775 373878 88092 64035987
Activated partial thromboplastin time prolonged 56.03 11.40 5 374648 12826 64111253
Unevaluable event 55.93 11.40 132 374521 50357 64073722
Blood lactate dehydrogenase increased 55.64 11.40 66 374587 33012 64091067
Renal injury 55.56 11.40 11 374642 15418 64108661
Drug level abnormal 55.54 11.40 25 374628 154 64123925
Angioedema 55.52 11.40 179 374474 61642 64062437
Hidradenitis 55.33 11.40 68 374585 2261 64121818
IgA nephropathy 55.27 11.40 54 374599 1380 64122699
Prothrombin time prolonged 55.07 11.40 12 374641 15729 64108350
Blister 54.90 11.40 715 373938 80252 64043827
Onychomycosis 54.85 11.40 104 374549 5092 64118987
Grip strength decreased 54.55 11.40 171 374482 11553 64112526
Amyotrophic lateral sclerosis 54.21 11.40 57 374596 1593 64122486
Sleep apnoea syndrome 54.05 11.40 56 374597 29776 64094303
Hysterectomy 53.96 11.40 102 374551 4983 64119096
Aspartate aminotransferase increased 53.79 11.40 441 374212 119347 64004732
Blood glucose decreased 53.62 11.40 34 374619 23089 64100990
Cytomegalovirus colitis 53.61 11.40 88 374565 3840 64120239
Fear of injection 53.57 11.40 111 374542 5801 64118278
Dry skin 53.36 11.40 138 374515 51023 64073056
Atelectasis 53.09 11.40 48 374605 27218 64096861
General physical health deterioration 53.05 11.40 1559 373094 202866 63921213
Abscess intestinal 53.02 11.40 67 374586 2293 64121786
Injection site swelling 52.60 11.40 100 374553 41253 64082826
Pancreatitis acute 52.46 11.40 106 374547 42749 64081330
Abortion spontaneous 52.28 11.40 286 374367 24857 64099222
Cervix carcinoma 52.28 11.40 59 374594 1789 64122290
Intestinal sepsis 51.64 11.40 37 374616 605 64123474
Head injury 51.62 11.40 69 374584 32773 64091306
Product prescribing error 51.57 11.40 78 374575 35191 64088888
Wheezing 51.23 11.40 267 374386 80312 64043767
Dislocation of vertebra 51.00 11.40 76 374577 3048 64121031
Ankle deformity 50.67 11.40 37 374616 624 64123455
Paranoia 50.49 11.40 16 374637 16336 64107743
Cardiac failure acute 50.46 11.40 16 374637 16328 64107751
Mental impairment 50.45 11.40 16 374637 16327 64107752
Ankle operation 50.37 11.40 44 374609 970 64123109
Paradoxical psoriasis 50.33 11.40 22 374631 125 64123954
Arteriosclerosis coronary artery 50.13 11.40 14 374639 15515 64108564
Dyspepsia 50.01 11.40 268 374385 80044 64044035
Hypovolaemia 49.92 11.40 14 374639 15472 64108607
Nausea 49.92 11.40 3910 370743 781890 63342189
Blood loss anaemia 49.82 11.40 10 374643 13882 64110197
Pollakiuria 49.80 11.40 66 374587 31464 64092615
Enterocutaneous fistula 49.76 11.40 53 374600 1504 64122575
Salivary hypersecretion 49.60 11.40 6 374647 12107 64111972
Antinuclear antibody increased 49.58 11.40 45 374608 1045 64123034
Nephropathy toxic 49.21 11.40 20 374633 17494 64106585
Impaired quality of life 48.98 11.40 113 374540 6358 64117721
Haemodynamic instability 48.97 11.40 13 374640 14899 64109180
Blood iron abnormal 48.93 11.40 46 374607 1119 64122960
Eosinophil count increased 48.89 11.40 11 374642 14101 64109978
White blood cell count increased 48.88 11.40 207 374446 65807 64058272
Tongue disorder 48.86 11.40 168 374485 11912 64112167
Chromaturia 48.76 11.40 36 374617 22575 64101504
Cytomegalovirus infection 48.40 11.40 376 374277 36823 64087256
Listeria sepsis 48.14 11.40 35 374618 586 64123493
Double stranded DNA antibody 48.12 11.40 16 374637 35 64124044
Hypophosphataemia 48.02 11.40 13 374640 14707 64109372
Visual acuity reduced 47.99 11.40 52 374601 27089 64096990
Aplastic anaemia 47.92 11.40 11 374642 13909 64110170
Epistaxis 47.92 11.40 353 374300 97778 64026301
Dyspnoea 47.82 11.40 3562 371091 715112 63408967
Cervical dysplasia 47.72 11.40 57 374596 1839 64122240
Myocardial ischaemia 47.63 11.40 39 374614 23212 64100867
Tinnitus 47.52 11.40 78 374575 34055 64090024
Pyrexia 47.50 11.40 2708 371945 555936 63568143
Thirst 47.05 11.40 12 374641 14125 64109954
Psychomotor hyperactivity 46.70 11.40 13 374640 14438 64109641
Tubulointerstitial nephritis 46.52 11.40 67 374586 30842 64093237
Proctocolectomy 46.26 11.40 19 374634 90 64123989
Pulseless electrical activity 46.04 11.40 9 374644 12730 64111349
Sudden death 45.98 11.40 30 374623 20066 64104013
End stage renal disease 45.96 11.40 4 374649 10471 64113608
Shock haemorrhagic 45.85 11.40 20 374633 16771 64107308
Granulocytopenia 45.77 11.40 4 374649 10436 64113643
Tonsillitis 45.56 11.40 103 374550 5717 64118362
Infective pulmonary exacerbation of cystic fibrosis 45.56 11.40 7 374646 11789 64112290
Malaise 45.38 11.40 2772 371881 393475 63730604
Infected fistula 45.36 11.40 25 374628 250 64123829
Myelodysplastic syndrome 45.35 11.40 56 374597 27523 64096556
Muscle twitching 45.35 11.40 27 374626 18971 64105108
Opportunistic infection 45.25 11.40 66 374587 2596 64121483
Drug use disorder 45.03 11.40 105 374548 5949 64118130
Skin ulcer 44.83 11.40 421 374232 43553 64080526
Sports injury 44.54 11.40 21 374632 146 64123933
Loss of therapeutic response 44.36 11.40 25 374628 262 64123817
Muscle rigidity 44.36 11.40 23 374630 17450 64106629
Septic shock 44.27 11.40 395 374258 105042 64019037
Injection site rash 44.19 11.40 18 374635 15724 64108355
Hiatus hernia 44.05 11.40 31 374622 19926 64104153
Coeliac disease 44.03 11.40 118 374535 7294 64116785
Sarcoidosis 43.98 11.40 105 374548 6041 64118038
Spinal column injury 43.88 11.40 54 374599 1798 64122281
Pneumonitis 43.73 11.40 148 374505 50217 64073862
Supraventricular tachycardia 43.57 11.40 28 374625 18879 64105200
Abdominal pain upper 43.34 11.40 735 373918 174295 63949784
Terminal state 43.31 11.40 86 374567 4358 64119721
Gastric ulcer 43.12 11.40 68 374585 30166 64093913
Device occlusion 42.92 11.40 4 374649 9909 64114170
Hyperammonaemia 42.87 11.40 4 374649 9900 64114179
Iritis 42.79 11.40 70 374583 3046 64121033
Atrioventricular block 42.36 11.40 9 374644 12006 64112073
Transfusion 42.36 11.40 26 374627 17968 64106111
Petechiae 42.35 11.40 28 374625 18598 64105481
Vaginal fistula 42.34 11.40 23 374630 223 64123856
Lymphopenia 42.29 11.40 52 374601 25605 64098474
Latent tuberculosis 42.08 11.40 65 374588 2692 64121387
Gait disturbance 41.95 11.40 725 373928 171430 63952649
Blood pressure diastolic abnormal 41.87 11.40 9 374644 11908 64112171
Aspiration 41.73 11.40 23 374630 16862 64107217
Pericardial effusion 41.61 11.40 105 374548 39149 64084930
Polyuria 41.56 11.40 11 374642 12632 64111447
Cholelithiasis 41.39 11.40 131 374522 45375 64078704
Duodenal ulcer 41.35 11.40 16 374637 14419 64109660
Female genital tract fistula 41.03 11.40 63 374590 2595 64121484
Atypical mycobacterial infection 40.88 11.40 44 374609 1264 64122815
Mitral valve incompetence 40.81 11.40 53 374600 25485 64098594
Device malfunction 40.79 11.40 26 374627 17607 64106472
Proctitis 40.74 11.40 69 374584 3090 64120989
Anorectal disorder 40.35 11.40 53 374600 1886 64122193
Injection site induration 40.34 11.40 3 374650 8929 64115150
Joint effusion 40.15 11.40 170 374483 13303 64110776
Schizophrenia 40.13 11.40 8 374645 11160 64112919
Cytology abnormal 40.10 11.40 25 374628 320 64123759
Hepatitis acute 39.77 11.40 14 374639 13375 64110704
Atrioventricular block complete 39.65 11.40 17 374636 14401 64109678
Diplopia 39.32 11.40 59 374594 26706 64097373
Thrombotic microangiopathy 39.29 11.40 24 374629 16631 64107448
Hepatotoxicity 39.26 11.40 111 374542 39851 64084228
Deformity 39.19 11.40 102 374551 6195 64117884
Cardiomyopathy 39.11 11.40 54 374599 25302 64098777
Swollen tongue 39.02 11.40 91 374562 34863 64089216
Ventricular extrasystoles 38.99 11.40 27 374626 17502 64106577
Chronic recurrent multifocal osteomyelitis 38.91 11.40 15 374638 58 64124021
Wrist surgery 38.84 11.40 33 374620 700 64123379
Oesophagitis 38.74 11.40 41 374612 21589 64102490
Proctalgia 38.68 11.40 114 374539 7445 64116634
Gastritis 38.54 11.40 123 374530 42495 64081584
Serum ferritin decreased 38.53 11.40 50 374603 1758 64122321
Ageusia 38.44 11.40 16 374637 13797 64110282
Joint arthroplasty 38.25 11.40 53 374600 1987 64122092
Colon dysplasia 38.20 11.40 18 374635 125 64123954
Thinking abnormal 38.09 11.40 10 374643 11546 64112533
Decubitus ulcer 38.05 11.40 15 374638 13364 64110715
Affect lability 37.95 11.40 4 374649 8986 64115093
Intestinal tuberculosis 37.86 11.40 19 374634 154 64123925
Respiratory acidosis 37.72 11.40 6 374647 9849 64114230
Epstein-Barr virus associated lymphoma 37.59 11.40 36 374617 897 64123182
Coordination abnormal 37.54 11.40 20 374633 14944 64109135
Faeces discoloured 37.52 11.40 57 374596 25672 64098407
Toxic encephalopathy 37.51 11.40 6 374647 9809 64114270
Spleen tuberculosis 37.48 11.40 12 374641 22 64124057
Suffocation feeling 37.47 11.40 46 374607 1528 64122551
Diastolic dysfunction 37.33 11.40 4 374649 8871 64115208
Metastases to central nervous system 37.32 11.40 17 374636 13895 64110184
Hyperuricaemia 37.26 11.40 7 374646 10184 64113895
Small intestinal stenosis 37.18 11.40 31 374622 640 64123439
Hair follicle tumour benign 37.14 11.40 26 374627 409 64123670
Aphthous ulcer 37.04 11.40 161 374492 12745 64111334
Wheelchair user 36.93 11.40 83 374570 4589 64119490
Graft versus host disease 36.86 11.40 17 374636 13796 64110283
Nail disorder 36.70 11.40 122 374531 8502 64115577
Haemolytic anaemia 36.68 11.40 24 374629 16029 64108050
Hyperthyroidism 36.61 11.40 31 374622 18148 64105931
Colitis ischaemic 36.59 11.40 16 374637 13398 64110681
Renal disorder 36.41 11.40 96 374557 35269 64088810
Metastases to bone 36.30 11.40 39 374614 20396 64103683
Blood pressure diastolic increased 36.28 11.40 141 374512 10611 64113468
Blood lactic acid increased 36.25 11.40 8 374645 10393 64113686
Skin exfoliation 36.23 11.40 136 374517 44749 64079330
Erectile dysfunction 36.17 11.40 14 374639 12613 64111466
Myalgia 36.11 11.40 676 373977 157941 63966138
Haemorrhagic stroke 36.03 11.40 7 374646 9944 64114135
Abnormal dreams 36.02 11.40 8 374645 10348 64113731
Epstein-Barr virus infection 36.00 11.40 156 374497 12332 64111747
Acute graft versus host disease 35.99 11.40 5 374648 9079 64115000
Pulmonary thrombosis 35.55 11.40 138 374515 10380 64113699
Visual impairment 35.44 11.40 268 374385 73809 64050270
Injection site mass 35.33 11.40 29 374624 17241 64106838
Immune thrombocytopenia 35.14 11.40 22 374631 15044 64109035
Drug-induced liver injury 34.90 11.40 150 374503 47493 64076586
Substance abuse 34.80 11.40 6 374647 9286 64114793
Abdominal distension 34.68 11.40 373 374280 95621 64028458
Hiccups 34.66 11.40 4 374649 8372 64115707
Pharyngitis streptococcal 34.58 11.40 120 374533 8548 64115531
Gastrointestinal scarring 34.51 11.40 20 374633 222 64123857
Pneumonia viral 34.49 11.40 112 374541 7710 64116369
Neck deformity 34.40 11.40 46 374607 1666 64122413
Guttate psoriasis 34.31 11.40 24 374629 377 64123702
Cell marker increased 34.21 11.40 29 374624 613 64123466
Obliterative bronchiolitis 34.09 11.40 58 374595 2607 64121472
Device leakage 34.08 11.40 4 374649 8262 64115817
Malignant respiratory tract neoplasm 34.07 11.40 11 374642 21 64124058
Hip fracture 34.05 11.40 66 374587 27033 64097046
Colostomy 34.02 11.40 32 374621 779 64123300
Blood pressure diastolic decreased 33.93 11.40 234 374419 22067 64102012
Cutaneous lupus erythematosus 33.82 11.40 58 374595 2624 64121455
Acute pulmonary oedema 33.82 11.40 16 374637 12793 64111286
Neutrophil count increased 33.69 11.40 59 374594 25115 64098964
Bundle branch block right 33.63 11.40 9 374644 10260 64113819
Drug level increased 33.58 11.40 95 374558 34101 64089978
Proteinuria 33.57 11.40 69 374584 27654 64096425
Blood triglycerides increased 33.52 11.40 36 374617 18830 64105249
Stoma creation 33.29 11.40 10 374643 13 64124066
Protein urine present 33.07 11.40 6 374647 8950 64115129
Retinitis 33.01 11.40 50 374603 2035 64122044
Musculoskeletal disorder 32.85 11.40 197 374456 17709 64106370
Rectal haemorrhage 32.79 11.40 523 374130 61294 64062785
Concomitant disease aggravated 32.72 11.40 13 374640 11529 64112550
Gout 32.63 11.40 46 374607 21367 64102712
Premature labour 32.60 11.40 108 374545 7512 64116567
Pain in jaw 32.57 11.40 124 374529 40631 64083448
Pneumonia cryptococcal 32.43 11.40 38 374615 1201 64122878
Electrocardiogram abnormal 32.40 11.40 19 374634 13462 64110617
Diverticulitis 32.30 11.40 355 374298 38263 64085816
Mycobacterium avium complex infection 32.27 11.40 71 374582 3869 64120210
Coccidioidomycosis 32.26 11.40 36 374617 1078 64123001
Pulmonary haemorrhage 32.19 11.40 18 374635 13091 64110988
Polyneuropathy 32.08 11.40 41 374612 19853 64104226
Liver disorder 32.02 11.40 461 374192 52890 64071189
Osteonecrosis 31.91 11.40 73 374580 28156 64095923
Type 2 diabetes mellitus 31.88 11.40 320 374333 33700 64090379
Lymphoedema 31.84 11.40 9 374644 9896 64114183
Anastomotic ulcer 31.71 11.40 26 374627 524 64123555
Venous injury 31.69 11.40 27 374626 575 64123504
Arthritis bacterial 31.68 11.40 109 374544 7730 64116349
Mesenteritis 31.67 11.40 18 374635 192 64123887
Hypoacusis 31.64 11.40 64 374589 25803 64098276
Gastroenteritis salmonella 31.54 11.40 31 374622 798 64123281
Device difficult to use 31.32 11.40 9 374644 9789 64114290
Dementia 31.26 11.40 45 374608 20721 64103358
Pathogen resistance 31.12 11.40 17 374636 12526 64111553
Bladder neoplasm 31.08 11.40 41 374612 1465 64122614
Intervertebral disc space narrowing 31.08 11.40 39 374614 1325 64122754
SAPHO syndrome 31.04 11.40 16 374637 138 64123941
Arthritis enteropathic 31.03 11.40 19 374634 235 64123844
Joint injury 31.00 11.40 234 374419 22713 64101366
Nocturia 30.96 11.40 13 374640 11152 64112927
Lipase increased 30.96 11.40 23 374630 14379 64109700
Blindness 30.95 11.40 50 374603 21969 64102110
Injection site warmth 30.93 11.40 20 374633 13442 64110637
Cerebral haematoma 30.84 11.40 3 374650 7182 64116897
Bronchitis 30.83 11.40 445 374208 108298 64015781
Anastomotic stenosis 30.72 11.40 24 374629 450 64123629
Intestinal ulcer 30.71 11.40 43 374610 1628 64122451
Rectal cancer 30.66 11.40 57 374596 2749 64121330
Rales 30.63 11.40 26 374627 15203 64108876
Rheumatoid lung 30.47 11.40 53 374600 2426 64121653
Angina unstable 30.39 11.40 27 374626 15440 64108639
Peripheral sensory neuropathy 30.37 11.40 14 374639 11364 64112715
Caesarean section 30.36 11.40 138 374515 11136 64112943
Glycosylated haemoglobin increased 30.25 11.40 29 374624 15990 64108089
Feeling abnormal 30.22 11.40 570 374083 133032 63991047
Epicondylitis 30.18 11.40 45 374608 1806 64122273
Gastrointestinal carcinoma 30.01 11.40 47 374606 1970 64122109
Device breakage 29.98 11.40 7 374646 8748 64115331
Aplasia pure red cell 29.92 11.40 3 374650 7011 64117068
International normalised ratio decreased 29.90 11.40 4 374649 7474 64116605
Chondropathy 29.89 11.40 51 374602 2298 64121781
Apathy 29.70 11.40 14 374639 11218 64112861
Fibromyalgia 29.68 11.40 328 374325 35403 64088676
Ventricular arrhythmia 29.57 11.40 4 374649 7411 64116668
Onychomadesis 29.55 11.40 57 374596 2827 64121252
Temperature intolerance 29.48 11.40 6 374647 8249 64115830
Acute myeloid leukaemia 29.47 11.40 73 374580 27390 64096689
Bradyphrenia 29.41 11.40 9 374644 9397 64114682
Hepatitis cholestatic 29.40 11.40 17 374636 12138 64111941
Neuralgia 29.36 11.40 68 374585 26116 64097963
Colon cancer 29.29 11.40 149 374504 12590 64111489
Injection site discolouration 29.17 11.40 3 374650 6872 64117207
Personality change 29.17 11.40 7 374646 8586 64115493
Tonsillar ulcer 28.87 11.40 22 374631 397 64123682
Cholecystitis chronic 28.83 11.40 9 374644 9278 64114801
Exercise tolerance decreased 28.83 11.40 5 374648 7705 64116374
Complication associated with device 28.82 11.40 27 374626 15053 64109026
Suspected COVID-19 28.81 11.40 41 374612 1576 64122503
Dyslipidaemia 28.61 11.40 9 374644 9233 64114846
Ophthalmic herpes zoster 28.56 11.40 48 374605 2136 64121943
Neoplasm skin 28.52 11.40 35 374618 1162 64122917
Small intestinal obstruction 28.33 11.40 234 374419 23339 64100740
Embolic stroke 28.29 11.40 3 374650 6708 64117371
Cardiac murmur 28.22 11.40 16 374637 11547 64112532
Dry eye 28.21 11.40 81 374572 28938 64095141
Neuroendocrine carcinoma of the skin 28.21 11.40 32 374621 976 64123103
Smear cervix abnormal 28.20 11.40 50 374603 2324 64121755
Respiratory distress 28.13 11.40 183 374470 52148 64071931
Tendonitis 28.06 11.40 208 374445 20074 64104005
Heart rate increased 27.92 11.40 761 373892 97914 64026165
Lower respiratory tract infection viral 27.89 11.40 31 374622 924 64123155
Toxic skin eruption 27.85 11.40 43 374610 19241 64104838
Lupus vasculitis 27.82 11.40 23 374630 469 64123610
Leishmaniasis 27.81 11.40 20 374633 329 64123750
Nystagmus 27.77 11.40 9 374644 9059 64115020
Anaphylactoid reaction 27.71 11.40 75 374578 4663 64119416
Coronary artery occlusion 27.59 11.40 24 374629 13867 64110212
Vertigo 27.51 11.40 215 374438 58796 64065283
Accident 27.50 11.40 95 374558 6751 64117328
Disseminated intravascular coagulation 27.44 11.40 96 374557 32252 64091827
Granuloma 27.42 11.40 93 374560 6548 64117531
Cardiovascular disorder 27.42 11.40 172 374481 15709 64108370
Drug ineffective for unapproved indication 27.34 11.40 289 374364 30844 64093235
Blood chloride decreased 27.31 11.40 5 374648 7411 64116668
Meningitis tuberculous 27.31 11.40 33 374620 1078 64123001
Torus fracture 27.20 11.40 12 374641 70 64124009
Blood creatine increased 27.17 11.40 7 374646 8185 64115894
Coma scale abnormal 27.05 11.40 6 374647 7768 64116311
Blood uric acid increased 27.03 11.40 7 374646 8156 64115923
Hepatomegaly 27.01 11.40 35 374618 16847 64107232
Feeling jittery 27.00 11.40 14 374639 10621 64113458
Hodgkin's disease nodular sclerosis 26.97 11.40 9 374644 20 64124059
Pulmonary function test decreased 26.95 11.40 3 374650 6458 64117621
Low density lipoprotein increased 26.88 11.40 6 374647 7734 64116345
Coronary artery stenosis 26.83 11.40 16 374637 11232 64112847
Tachypnoea 26.70 11.40 73 374580 26498 64097581
Steroid dependence 26.69 11.40 21 374632 398 64123681
Post transplant lymphoproliferative disorder 26.65 11.40 11 374642 9533 64114546
Gastrointestinal stoma complication 26.59 11.40 47 374606 2179 64121900
Respiratory syncytial virus infection 26.55 11.40 5 374648 7263 64116816
Pallor 26.50 11.40 343 374310 38438 64085641
Blood thyroid stimulating hormone increased 26.45 11.40 6 374647 7648 64116431
Wisdom teeth removal 26.33 11.40 20 374633 359 64123720
Thyroid cancer 26.24 11.40 66 374587 3925 64120154
Hypertransaminasaemia 26.16 11.40 5 374648 7186 64116893
Red cell distribution width decreased 26.11 11.40 32 374621 1061 64123018
Respiratory tract infection 26.05 11.40 120 374533 37287 64086792
Haemorrhage 26.05 11.40 315 374338 79036 64045043
Joint ankylosis 26.05 11.40 27 374626 742 64123337
Periumbilical abscess 25.99 11.40 11 374642 57 64124022
Hypoxic-ischaemic encephalopathy 25.96 11.40 5 374648 7147 64116932
Peritonitis bacterial 25.94 11.40 10 374643 9033 64115046
Acute generalised exanthematous pustulosis 25.91 11.40 26 374627 14032 64110047
Shoulder arthroplasty 25.89 11.40 52 374601 2657 64121422
Ear infection bacterial 25.88 11.40 10 374643 39 64124040
Ankle arthroplasty 25.76 11.40 29 374624 877 64123202
Mood altered 25.70 11.40 33 374620 15946 64108133
Azotaemia 25.68 11.40 6 374647 7496 64116583
Renal cell carcinoma 25.66 11.40 86 374567 6018 64118061
Posterior reversible encephalopathy syndrome 25.40 11.40 60 374593 22886 64101193
Exposure to SARS-CoV-2 25.38 11.40 23 374630 533 64123546
Blood pressure systolic abnormal 25.37 11.40 13 374640 9929 64114150
Large intestinal ulcer 25.16 11.40 67 374586 4126 64119953
Prostate cancer 25.15 11.40 199 374454 19596 64104483
Tongue neoplasm malignant stage unspecified 25.14 11.40 29 374624 901 64123178
Gastric ulcer haemorrhage 25.09 11.40 8 374645 8135 64115944
Ventricular hypokinesia 25.09 11.40 7 374646 7762 64116317
Brachiocephalic artery stenosis 25.07 11.40 9 374644 27 64124052
Hydronephrosis 25.04 11.40 27 374626 14098 64109981
Plasmablastic lymphoma 24.99 11.40 20 374633 389 64123690
Rectal tenesmus 24.96 11.40 31 374622 1042 64123037
Clonus 24.85 11.40 3 374650 6064 64118015
Surgery 24.83 11.40 262 374391 27951 64096128
Cough 24.81 11.40 1469 373184 300679 63823400
Orthopnoea 24.75 11.40 11 374642 9123 64114956
Bone density decreased 24.73 11.40 119 374534 9833 64114246
Stupor 24.68 11.40 3 374650 6032 64118047
Pneumocystis jirovecii infection 24.61 11.40 47 374606 2314 64121765
Cholecystitis acute 24.61 11.40 18 374635 11342 64112737
Device related infection 24.59 11.40 93 374560 30533 64093546
Product complaint 24.55 11.40 20 374633 11934 64112145
Tuberculosis of central nervous system 24.48 11.40 20 374633 401 64123678
Pulmonary congestion 24.45 11.40 65 374588 23815 64100264
Lower gastrointestinal haemorrhage 24.32 11.40 27 374626 13912 64110167
Seronegative arthritis 24.27 11.40 51 374602 2692 64121387
Productive cough 24.25 11.40 290 374363 72913 64051166
Superficial spreading melanoma stage unspecified 24.25 11.40 17 374636 268 64123811
Hodgkin's disease stage II 24.22 11.40 8 374645 17 64124062
Hypoalbuminaemia 24.04 11.40 41 374612 17633 64106446
Tooth abscess 24.03 11.40 150 374503 13676 64110403
Amnesia 23.86 11.40 173 374480 48096 64075983
Pregnancy of partner 23.85 11.40 16 374637 234 64123845
Wound infection 23.83 11.40 158 374495 14706 64109373
Spondyloarthropathy 23.79 11.40 26 374627 760 64123319
Stress cardiomyopathy 23.78 11.40 12 374641 9245 64114834
COVID-19 pneumonia 23.65 11.40 37 374616 16467 64107612
Multiple allergies 23.64 11.40 81 374572 5733 64118346
Drug exposure before pregnancy 23.63 11.40 21 374632 474 64123605
Lip ulceration 23.58 11.40 42 374611 1959 64122120
Pharyngeal paraesthesia 23.58 11.40 41 374612 1876 64122203
Mycobacterial infection 23.52 11.40 53 374600 2935 64121144
Ileostomy closure 23.50 11.40 13 374640 131 64123948
Disease susceptibility 23.50 11.40 16 374637 240 64123839
Drug abuser 23.48 11.40 3 374650 5805 64118274
Left ventricular hypertrophy 23.42 11.40 13 374640 9493 64114586
Renal neoplasm 23.40 11.40 38 374615 1643 64122436
Arteriosclerosis 23.32 11.40 35 374618 15842 64108237
Apnoea 23.25 11.40 16 374637 10406 64113673
Sacroiliitis 23.24 11.40 53 374600 2959 64121120
Small intestine carcinoma 23.20 11.40 26 374627 782 64123297
Laryngeal cancer 23.20 11.40 24 374629 658 64123421
Muscle haemorrhage 23.19 11.40 3 374650 5750 64118329
Joint lock 23.17 11.40 51 374602 2780 64121299
Myopathy 23.15 11.40 42 374611 17638 64106441
Hemiplegia 23.09 11.40 24 374629 12744 64111335
Restless legs syndrome 23.01 11.40 40 374613 17076 64107003
Staphylococcal bacteraemia 22.96 11.40 16 374637 10339 64113740
Metabolic disorder 22.95 11.40 8 374645 7689 64116390
Intestinal ischaemia 22.88 11.40 20 374633 11529 64112550
Femoral neck fracture 22.87 11.40 11 374642 8713 64115366
Pruritus 22.80 11.40 2109 372544 310291 63813788
Amylase increased 22.79 11.40 14 374639 9671 64114408
Hypomania 22.66 11.40 3 374650 5651 64118428
Neck mass 22.65 11.40 63 374590 3981 64120098
Pathological fracture 22.64 11.40 12 374641 8993 64115086
Tuberculosis liver 22.57 11.40 10 374643 59 64124020
Testicular seminoma (pure) 22.55 11.40 9 374644 39 64124040
Endometriosis 22.52 11.40 50 374603 2742 64121337
Middle insomnia 22.40 11.40 25 374628 12852 64111227
Secondary amyloidosis 22.39 11.40 12 374641 113 64123966
Pyoderma 22.30 11.40 17 374636 307 64123772
Anal fistula infection 22.30 11.40 10 374643 61 64124018
Pelvic abscess 22.10 11.40 39 374614 1806 64122273
Malignant melanoma stage I 22.03 11.40 12 374641 117 64123962
Orbital apex syndrome 22.03 11.40 10 374643 63 64124016
Rib fracture 22.00 11.40 69 374584 23969 64100110
Incoherent 21.92 11.40 7 374646 7111 64116968
Duodenal ulcer haemorrhage 21.77 11.40 5 374648 6320 64117759
Mixed liver injury 21.75 11.40 3 374650 5478 64118601
Erythema multiforme 21.74 11.40 36 374617 15665 64108414
Dizziness postural 21.72 11.40 15 374638 9737 64114342
Gastrointestinal stenosis 21.69 11.40 14 374639 191 64123888
Taste disorder 21.69 11.40 14 374639 9419 64114660
Adverse drug reaction 21.66 11.40 378 374275 45086 64078993
Salpingectomy 21.64 11.40 13 374640 155 64123924
Gastric haemorrhage 21.51 11.40 28 374625 13453 64110626
Gastrointestinal cancer metastatic 21.51 11.40 14 374639 194 64123885
Herpes ophthalmic 21.49 11.40 31 374622 1207 64122872
Ileus paralytic 21.48 11.40 11 374642 8404 64115675
Hypogammaglobulinaemia 21.44 11.40 17 374636 10282 64113797
Injection site urticaria 21.39 11.40 20 374633 11161 64112918
Vulval abscess 21.36 11.40 22 374631 600 64123479
Brain injury 21.31 11.40 16 374637 9949 64114130
Maternal exposure timing unspecified 21.29 11.40 48 374605 2659 64121420
Peripheral arterial occlusive disease 21.28 11.40 7 374646 6980 64117099
Euphoric mood 21.17 11.40 6 374647 6585 64117494
Jaundice cholestatic 21.15 11.40 12 374641 8658 64115421
Blood magnesium decreased 21.06 11.40 30 374623 13875 64110204
Brain natriuretic peptide increased 20.99 11.40 9 374644 7624 64116455
Pulse absent 20.95 11.40 13 374640 8933 64115146
Bladder repair 20.90 11.40 9 374644 49 64124030
Bone disorder 20.90 11.40 41 374612 16718 64107361
Electrocardiogram ST segment elevation 20.87 11.40 8 374645 7251 64116828
Hypermobility syndrome 20.83 11.40 20 374633 500 64123579
Ventricular hypertrophy 20.80 11.40 6 374647 6510 64117569
Neoplasm prostate 20.80 11.40 12 374641 132 64123947
Drain placement 20.80 11.40 12 374641 132 64123947
Stoma site rash 20.77 11.40 5 374648 0 64124079
Anorectal ulcer 20.76 11.40 9 374644 50 64124029
Non-consummation 20.76 11.40 9 374644 50 64124029
Postoperative abscess 20.74 11.40 21 374632 561 64123518
Lung neoplasm 20.72 11.40 82 374571 6223 64117856
Carcinoma in situ of skin 20.68 11.40 13 374640 169 64123910
Drug specific antibody absent 20.65 11.40 12 374641 134 64123945
Obstruction 20.61 11.40 53 374600 3195 64120884
Perineal abscess 20.59 11.40 19 374634 451 64123628
Sinus disorder 20.54 11.40 42 374611 16866 64107213
Oral mucosal blistering 20.47 11.40 3 374650 5234 64118845
Small intestine adenocarcinoma 20.42 11.40 12 374641 137 64123942
Hypotonia 20.36 11.40 21 374632 11191 64112888
Antibody test abnormal 20.35 11.40 20 374633 515 64123564
Bundle branch block left 20.34 11.40 17 374636 10017 64114062
Takayasu's arteritis 20.33 11.40 6 374647 7 64124072
Fistula repair 20.33 11.40 9 374644 53 64124026
No adverse event 20.26 11.40 91 374562 28470 64095609
Anaplastic large-cell lymphoma 20.17 11.40 13 374640 177 64123902
Transurethral prostatectomy 20.17 11.40 13 374640 177 64123902
Anorectal stenosis 20.17 11.40 8 374645 34 64124045
Ear neoplasm 20.13 11.40 11 374642 108 64123971
Overgrowth bacterial 20.12 11.40 12 374641 141 64123938
Stress 20.11 11.40 477 374176 60057 64064022
Renal tubular disorder 20.08 11.40 5 374648 5982 64118097
Blood pressure abnormal 20.08 11.40 33 374620 14402 64109677
Intestinal anastomosis 20.02 11.40 19 374634 468 64123611
Crohn's disease 20.00 11.40 39 374614 1950 64122129
Acute respiratory distress syndrome 20 11.40 138 374515 38797 64085282
Hypertensive crisis 19.98 11.40 48 374605 18200 64105879
Blood glucose fluctuation 19.92 11.40 5 374648 5950 64118129
Spinal osteoarthritis 19.75 11.40 33 374620 14308 64109771
Urine abnormality 19.74 11.40 9 374644 7353 64116726
Mouth ulceration 19.72 11.40 281 374372 32163 64091916
Pemphigoid 19.69 11.40 28 374625 12958 64111121
Bowel movement irregularity 19.68 11.40 67 374586 4726 64119353
Lewis-Sumner syndrome 19.63 11.40 8 374645 37 64124042
Psychiatric symptom 19.62 11.40 6 374647 6267 64117812
Bone cyst 19.62 11.40 41 374612 2156 64121923
Skin discolouration 19.61 11.40 122 374531 35133 64088946
C-reactive protein decreased 19.49 11.40 40 374613 2076 64122003
Partial seizures 19.49 11.40 9 374644 7298 64116781
Blood urine present 19.48 11.40 49 374604 18291 64105788
Eyelid ptosis 19.48 11.40 16 374637 9509 64114570
Aplasia 19.44 11.40 8 374645 6945 64117134
Carotid artery stenosis 19.36 11.40 11 374642 7930 64116149
Cardiac pacemaker insertion 19.35 11.40 3 374650 5020 64119059
Diabetic eye disease 19.29 11.40 12 374641 153 64123926
Drainage 19.26 11.40 7 374646 22 64124057
Blood calcium increased 19.21 11.40 13 374640 8529 64115550
International normalised ratio abnormal 19.17 11.40 3 374650 4985 64119094
Joint range of motion decreased 19.12 11.40 184 374469 19159 64104920
Bladder transitional cell carcinoma 19.10 11.40 42 374611 2288 64121791
Wrist deformity 18.97 11.40 36 374617 1764 64122315
Lip and/or oral cavity cancer 18.96 11.40 19 374634 501 64123578
Blood phosphorus increased 18.95 11.40 3 374650 4943 64119136
Performance status decreased 18.95 11.40 4 374649 5360 64118719
Stomal hernia 18.95 11.40 15 374638 287 64123792
Impaired gastric emptying 18.88 11.40 101 374552 8703 64115376
Cerebral ischaemia 18.85 11.40 18 374635 9944 64114135
Dermatitis acneiform 18.78 11.40 13 374640 8430 64115649
Mean platelet volume decreased 18.71 11.40 35 374618 1696 64122383
Adjustment disorder with depressed mood 18.70 11.40 43 374610 2414 64121665
Blood phosphorus decreased 18.68 11.40 5 374648 5700 64118379
Coronary arterial stent insertion 18.62 11.40 5 374648 5687 64118392
Cutaneous tuberculosis 18.60 11.40 13 374640 204 64123875
Mass 18.55 11.40 152 374501 15124 64108955
Secretion discharge 18.47 11.40 126 374527 11838 64112241
Joint dislocation 18.46 11.40 122 374531 11343 64112736
Eye movement disorder 18.45 11.40 9 374644 7070 64117009
Tuberculosis of eye 18.37 11.40 8 374645 45 64124034
Failure to thrive 18.32 11.40 20 374633 10384 64113695
Dysstasia 18.31 11.40 71 374582 23144 64100935
Gastrointestinal mucosa hyperaemia 18.31 11.40 17 374636 407 64123672
Enterocolonic fistula 18.25 11.40 11 374642 132 64123947
Swelling face 18.24 11.40 238 374415 58928 64065151
Vaginal abscess 18.22 11.40 15 374638 304 64123775
Blood glucose abnormal 18.19 11.40 15 374638 8898 64115181
Gangrene 18.13 11.40 10 374643 7328 64116751
Libido decreased 18.11 11.40 3 374650 4781 64119298
Extrasystoles 18.07 11.40 8 374645 6650 64117429
Phototherapy 17.98 11.40 7 374646 28 64124051
Occult blood positive 17.96 11.40 7 374646 6280 64117799
Limb operation 17.94 11.40 46 374607 2768 64121311
Embolism 17.94 11.40 27 374626 12208 64111871
Cervix carcinoma stage 0 17.92 11.40 13 374640 217 64123862
Cerebral atrophy 17.89 11.40 10 374643 7275 64116804
Lacunar infarction 17.83 11.40 5 374648 5527 64118552
Foot deformity 17.83 11.40 160 374493 16344 64107735
Hypovolaemic shock 17.79 11.40 20 374633 10246 64113833
Haemorrhagic diathesis 17.74 11.40 5 374648 5509 64118570
SARS-CoV-2 test positive 17.72 11.40 78 374575 6208 64117871
Impaired work ability 17.72 11.40 150 374503 15069 64109010
Joint tuberculosis 17.63 11.40 11 374642 141 64123938
Epstein Barr virus positive mucocutaneous ulcer 17.62 11.40 21 374632 676 64123403
Streptococcal infection 17.56 11.40 88 374565 7391 64116688
Upper respiratory tract infection 17.56 11.40 307 374346 72478 64051601
Brain herniation 17.50 11.40 8 374645 6525 64117554
Rectal cancer metastatic 17.48 11.40 17 374636 432 64123647
Gastrointestinal fistula 17.45 11.40 20 374633 617 64123462
Growth retardation 17.42 11.40 32 374621 1529 64122550
Urticarial vasculitis 17.41 11.40 17 374636 434 64123645
Heavy menstrual bleeding 17.37 11.40 27 374626 12050 64112029
Aortic arteriosclerosis 17.32 11.40 11 374642 7465 64116614
Autoimmune hepatitis 17.27 11.40 109 374544 9975 64114104
Nephropathy 17.26 11.40 14 374639 8372 64115707
Postoperative wound infection 17.26 11.40 111 374542 10225 64113854
Product substitution 17.23 11.40 9 374644 80 64123999
Conjunctival haemorrhage 17.22 11.40 4 374649 5017 64119062
Sexual dysfunction 17.21 11.40 8 374645 6463 64117616
Double stranded DNA antibody positive 17.20 11.40 16 374637 384 64123695
Disseminated coccidioidomycosis 17.17 11.40 8 374645 54 64124025
Blood pressure inadequately controlled 17.11 11.40 5 374648 5379 64118700
Incorrect dosage administered 16.99 11.40 39 374614 2187 64121892
Faecal calprotectin decreased 16.95 11.40 9 374644 83 64123996
Skin burning sensation 16.87 11.40 22 374631 10561 64113518
Paraesthesia 16.85 11.40 625 374028 133897 63990182
Pulmonary alveolar haemorrhage 16.84 11.40 19 374634 9719 64114360
Injection site haemorrhage 16.84 11.40 78 374575 24200 64099879
Faecaloma 16.80 11.40 19 374634 9709 64114370
Skin abrasion 16.79 11.40 26 374627 11619 64112460
Sigmoidectomy 16.71 11.40 6 374647 18 64124061
Lung cancer metastatic 16.69 11.40 48 374605 3092 64120987
Vaginal haemorrhage 16.68 11.40 57 374596 19287 64104792
Adenocarcinoma 16.64 11.40 50 374603 3301 64120778
Anal dilatation 16.62 11.40 4 374649 0 64124079
Premature delivery 16.56 11.40 54 374599 18535 64105544
Haemolysis 16.54 11.40 24 374629 11015 64113064
Perineal fistula 16.47 11.40 6 374647 19 64124060
Visceral leishmaniasis 16.47 11.40 24 374629 943 64123136
Bone tuberculosis 16.46 11.40 17 374636 465 64123614
Cortical dysplasia 16.43 11.40 5 374648 7 64124072
Brain death 16.42 11.40 4 374649 4857 64119222
Rectal discharge 16.37 11.40 18 374635 530 64123549
Anal skin tags 16.36 11.40 15 374638 353 64123726
Diffuse large B-cell lymphoma stage II 16.33 11.40 9 374644 90 64123989
Salmonella sepsis 16.33 11.40 15 374638 354 64123725
Gastritis erosive 16.29 11.40 19 374634 9576 64114503
Blood bicarbonate decreased 16.26 11.40 4 374649 4825 64119254
Pseudopolyposis 16.24 11.40 8 374645 62 64124017
Cytomegalovirus enteritis 16.20 11.40 20 374633 668 64123411
Mean cell volume decreased 16.18 11.40 51 374602 3455 64120624
Hypoaesthesia 16.17 11.40 652 374001 138456 63985623
Cholecystitis 16.17 11.40 59 374594 19577 64104502
Nervousness 16.06 11.40 103 374550 29453 64094626
Metastases to lung 16.04 11.40 41 374612 15223 64108856
Palmoplantar pustulosis 16.03 11.40 17 374636 480 64123599
Intestinal anastomosis complication 16.02 11.40 13 374640 258 64123821
Hypercalcaemia 15.98 11.40 264 374389 31152 64092927
Dysplasia 15.95 11.40 26 374627 1128 64122951
Lip swelling 15.94 11.40 114 374539 31793 64092286
Infected cyst 15.91 11.40 24 374629 973 64123106
Back pain 15.89 11.40 1244 373409 248927 63875152
Methaemoglobinaemia 15.87 11.40 3 374650 4345 64119734
Muscle tightness 15.85 11.40 25 374628 11090 64112989
Multifocal motor neuropathy 15.84 11.40 7 374646 41 64124038
Complications of bone marrow transplant 15.83 11.40 19 374634 616 64123463
Parainfluenzae virus infection 15.83 11.40 4 374649 4739 64119340
Stoma obstruction 15.82 11.40 8 374645 66 64124013
Eye pain 15.80 11.40 113 374540 31512 64092567
Peritonsillar abscess 15.74 11.40 21 374632 759 64123320
Ocular icterus 15.72 11.40 5 374648 5093 64118986
Retinal haemorrhage 15.67 11.40 12 374641 7386 64116693
Cutaneous nocardiosis 15.66 11.40 11 374642 174 64123905
Atrioventricular block second degree 15.65 11.40 9 374644 6445 64117634
Oesophageal fibrosis 15.61 11.40 11 374642 175 64123904
Anal squamous cell carcinoma 15.60 11.40 16 374637 434 64123645
Renal colic 15.57 11.40 39 374614 2313 64121766
Injury 15.56 11.40 230 374423 55762 64068317
Cystitis haemorrhagic 15.50 11.40 14 374639 7942 64116137
Soft tissue disorder 15.44 11.40 48 374605 3228 64120851
Pus in stool 15.41 11.40 6 374647 24 64124055
Blood iron decreased 15.39 11.40 122 374531 12020 64112059
Enterocolitis 15.34 11.40 29 374624 11989 64112090
Arthritis salmonella 15.34 11.40 5 374648 10 64124069
Vitreous floaters 15.29 11.40 9 374644 6364 64117715
Compartment syndrome 15.27 11.40 3 374650 4229 64119850
Aortic stenosis 15.26 11.40 9 374644 6356 64117723
Vaginal ulceration 15.23 11.40 12 374641 228 64123851
Device failure 15.20 11.40 7 374646 5685 64118394
Lymphadenitis bacterial 15.18 11.40 7 374646 46 64124033
Tonsil cancer 15.17 11.40 23 374630 937 64123142
Gynaecomastia 15.15 11.40 8 374645 6008 64118071
Acute pulmonary histoplasmosis 15.14 11.40 12 374641 230 64123849
Malignant melanoma in situ 15.14 11.40 33 374620 1787 64122292
Papilloma viral infection 15.08 11.40 29 374624 1435 64122644
Blood albumin decreased 15.03 11.40 67 374586 21006 64103073
Left ventricular failure 15.02 11.40 16 374637 8401 64115678
Squamous cell carcinoma of lung 15.01 11.40 35 374618 1983 64122096
Craniocerebral injury 14.99 11.40 3 374650 4173 64119906
Gastroenteritis viral 14.99 11.40 178 374475 19551 64104528
Neurogenic shock 14.89 11.40 17 374636 522 64123557
Interstitial lung disease 14.85 11.40 443 374210 97289 64026790
Self-medication 14.83 11.40 3 374650 4142 64119937
Skin hypertrophy 14.77 11.40 4 374649 4525 64119554
Immunosuppression 14.75 11.40 110 374543 10636 64113443
Urosepsis 14.73 11.40 72 374581 22022 64102057
Erythrodermic psoriasis 14.72 11.40 30 374623 1549 64122530
Optic neuritis 14.70 11.40 89 374564 8027 64116052
Lung consolidation 14.70 11.40 14 374639 7744 64116335
Vulval cancer stage 0 14.69 11.40 7 374646 50 64124029
Histone antibody positive 14.69 11.40 8 374645 78 64124001
Mastitis 14.65 11.40 34 374619 1920 64122159
Ileus 14.65 11.40 76 374577 22890 64101189
Amenorrhoea 14.64 11.40 10 374643 6529 64117550
Benign neoplasm 14.62 11.40 22 374631 890 64123189
Serum sickness-like reaction 14.61 11.40 17 374636 533 64123546
Heart rate abnormal 14.59 11.40 63 374590 4972 64119107
Hypercholesterolaemia 14.59 11.40 145 374508 15228 64108851
Nodule 14.56 11.40 164 374489 17783 64106296
Sinus node dysfunction 14.56 11.40 11 374642 6817 64117262
Spinal compression fracture 14.54 11.40 41 374612 14734 64109345
Chlamydial infection 14.53 11.40 15 374638 410 64123669
Rheumatoid factor increased 14.53 11.40 28 374625 1388 64122691
Haemothorax 14.49 11.40 5 374648 4837 64119242
Multiple-drug resistance 14.48 11.40 10 374643 6492 64117587
Ovarian cancer metastatic 14.47 11.40 16 374637 474 64123605
Adjusted calcium decreased 14.46 11.40 10 374643 154 64123925
Therapeutic product effect delayed 14.46 11.40 40 374613 2519 64121560
Foreign body in eye 14.46 11.40 11 374642 198 64123881
Vaginal flatulence 14.40 11.40 4 374649 3 64124076
Anal neoplasm 14.40 11.40 4 374649 3 64124076
Lupus pleurisy 14.40 11.40 4 374649 3 64124076
Circumcision 14.40 11.40 4 374649 3 64124076
Cytomegalovirus mononucleosis 14.40 11.40 4 374649 3 64124076
Scleroderma 14.38 11.40 5 374648 4813 64119266
Ear infection 14.34 11.40 203 374450 23201 64100878
Autoimmune haemolytic anaemia 14.33 11.40 12 374641 7064 64117015
Investigation abnormal 14.31 11.40 27 374626 1317 64122762
Sleep disorder due to a general medical condition 14.31 11.40 16 374637 8218 64115861
Intercepted product prescribing error 14.30 11.40 12 374641 250 64123829
Genital cyst 14.24 11.40 7 374646 54 64124025
Vulval disorder 14.23 11.40 16 374637 483 64123596
Alopecia areata 14.21 11.40 29 374624 1499 64122580
Muscle strain 14.16 11.40 16 374637 8178 64115901
Hepatic necrosis 14.15 11.40 17 374636 8456 64115623
Nasopharyngeal cancer 14.14 11.40 10 374643 160 64123919
Blood cholesterol increased 14.12 11.40 386 374267 49680 64074399
Epstein-Barr virus associated lymphoproliferative disorder 14.06 11.40 45 374608 3074 64121005
Hydrocephalus 14.03 11.40 14 374639 7577 64116502
Anal ulcer 14.01 11.40 24 374629 1085 64122994
Hyperaemia 14 11.40 41 374612 2668 64121411
Hyperphosphataemia 14.00 11.40 3 374650 3978 64120101
Enterovesical fistula 14.00 11.40 22 374631 925 64123154
Rheumatoid factor 14.00 11.40 9 374644 122 64123957
Respiratory disorder 13.98 11.40 138 374515 35973 64088106
Bowen's disease 13.93 11.40 9 374644 123 64123956
Central nervous system lesion 13.92 11.40 30 374623 11819 64112260
Thrombosis in device 13.91 11.40 6 374647 5065 64119014
Therapeutic product effect variable 13.89 11.40 30 374623 1614 64122465
Generalised oedema 13.87 11.40 68 374585 20785 64103294
Drug tolerance 13.87 11.40 71 374582 6014 64118065
Aortic bruit 13.83 11.40 11 374642 212 64123867
Product storage error 13.82 11.40 36 374617 13282 64110797
Burning sensation 13.80 11.40 204 374449 49460 64074619
Tachyarrhythmia 13.78 11.40 9 374644 6017 64118062
Application site erythema 13.76 11.40 5 374648 4684 64119395
Fracture 13.76 11.40 59 374594 18696 64105383
Eructation 13.75 11.40 20 374633 9171 64114908
Therapy partial responder 13.73 11.40 24 374629 10224 64113855
Sleep disorder 13.72 11.40 254 374399 59455 64064624
Cyclic neutropenia 13.69 11.40 5 374648 16 64124063
Rectal cancer stage III 13.69 11.40 5 374648 16 64124063
Oral pustule 13.68 11.40 12 374641 266 64123813
Bone density abnormal 13.67 11.40 41 374612 2704 64121375
Cerebellar syndrome 13.66 11.40 6 374647 5010 64119069
Colon injury 13.63 11.40 10 374643 170 64123909
Extranodal marginal zone B-cell lymphoma (MALT type) 13.62 11.40 16 374637 507 64123572
Areflexia 13.61 11.40 6 374647 5001 64119078
Oophoritis 13.60 11.40 6 374647 35 64124044
Bile acid malabsorption 13.58 11.40 10 374643 171 64123908
Respiratory alkalosis 13.57 11.40 3 374650 3894 64120185
Parosmia 13.53 11.40 5 374648 4635 64119444
Lip neoplasm malignant stage unspecified 13.46 11.40 5 374648 17 64124062
Purpura 13.44 11.40 53 374600 17193 64106886
Disease complication 13.43 11.40 4 374649 4251 64119828
Abscess limb 13.43 11.40 71 374582 6090 64117989
Neck surgery 13.41 11.40 28 374625 1471 64122608
Oropharyngeal discomfort 13.41 11.40 64 374589 5271 64118808
Intestinal malrotation 13.40 11.40 4 374649 5 64124074
Skin hyperpigmentation 13.40 11.40 11 374642 6540 64117539
Diverticulum intestinal 13.36 11.40 14 374639 7406 64116673
Retroperitoneal abscess 13.34 11.40 13 374640 331 64123748
Vaginal haematoma 13.33 11.40 9 374644 133 64123946
Breath sounds abnormal 13.33 11.40 30 374623 11639 64112440
Nephritis bacterial 13.32 11.40 6 374647 37 64124042
Supraventricular extrasystoles 13.30 11.40 9 374644 5906 64118173
Ovarian cancer 13.28 11.40 46 374607 3273 64120806
Portal hypertension 13.28 11.40 10 374643 6209 64117870
Large intestine anastomosis 13.27 11.40 8 374645 96 64123983
Mononeuropathy multiplex 13.25 11.40 13 374640 334 64123745
Aortic valve stenosis 13.25 11.40 5 374648 4575 64119504
Myeloid leukaemia 13.25 11.40 17 374636 591 64123488
Pharyngeal cyst 13.25 11.40 5 374648 18 64124061
Injection site papule 13.20 11.40 20 374633 814 64123265
Cytomegalovirus chorioretinitis 13.18 11.40 6 374647 4906 64119173
Emotional disorder 13.15 11.40 34 374619 12573 64111506
Thrombosis 13.15 11.40 311 374342 70331 64053748
Faeces soft 13.13 11.40 68 374585 5787 64118292
Groin abscess 13.12 11.40 26 374627 1316 64122763
Colostomy closure 13.10 11.40 10 374643 181 64123898
Chest pain 13.09 11.40 1186 373467 234794 63889285
Vaginal infection 13.08 11.40 60 374593 4860 64119219
Transplant failure 13.06 11.40 3 374650 3791 64120288
Tooth infection 13.04 11.40 136 374517 14465 64109614
Post procedural infection 13.04 11.40 98 374555 9499 64114580
Ecchymosis 13.01 11.40 40 374613 13982 64110097
Laboratory test abnormal 13.01 11.40 84 374569 23979 64100100
Ear injury 13.00 11.40 10 374643 183 64123896
Enteropathy-associated T-cell lymphoma 12.99 11.40 4 374649 6 64124073
Salpingo-oophorectomy 12.99 11.40 4 374649 6 64124073
Exploratory operation 12.99 11.40 4 374649 6 64124073
Dental caries 12.97 11.40 27 374626 10773 64113306
Genital haemorrhage 12.97 11.40 8 374645 5514 64118565
Dermatitis bullous 12.96 11.40 32 374621 12022 64112057
White coat hypertension 12.95 11.40 15 374638 468 64123611
Therapy change 12.92 11.40 11 374642 6423 64117656
Seminoma 12.91 11.40 10 374643 185 64123894
Non-cardiac chest pain 12.88 11.40 19 374634 8661 64115418
Liver function test increased 12.84 11.40 252 374401 30718 64093361
Neutrophilia 12.78 11.40 12 374641 6682 64117397
Obsessive-compulsive disorder 12.75 11.40 6 374647 4812 64119267
Oophorectomy 12.73 11.40 11 374642 239 64123840
Dyshidrotic eczema 12.70 11.40 16 374637 546 64123533
Catheter site pain 12.69 11.40 5 374648 4457 64119622
Behaviour disorder 12.69 11.40 5 374648 4457 64119622
Pseudomonas infection 12.67 11.40 57 374596 17826 64106253
Incorrect dose administered by device 12.67 11.40 4 374649 4093 64119986
Breast abscess 12.65 11.40 23 374630 1090 64122989
Pharyngeal neoplasm 12.65 11.40 5 374648 21 64124058
Hypertriglyceridaemia 12.64 11.40 29 374624 11176 64112903
Bursitis infective 12.64 11.40 24 374629 1176 64122903
Shrinking lung syndrome 12.61 11.40 4 374649 7 64124072
Vitamin D deficiency 12.61 11.40 31 374622 11661 64112418
Listeria encephalitis 12.60 11.40 12 374641 297 64123782
Skin plaque 12.55 11.40 92 374561 8848 64115231
Cutaneous lymphoma 12.54 11.40 11 374642 244 64123835
Logorrhoea 12.48 11.40 4 374649 4055 64120024
Bifidobacterium infection 12.47 11.40 5 374648 22 64124057
Mastoidectomy 12.46 11.40 3 374650 0 64124079
Jejunectomy 12.46 11.40 3 374650 0 64124079
Anal dilation procedure 12.46 11.40 3 374650 0 64124079
Endometrial neoplasm 12.46 11.40 3 374650 0 64124079
Rotavirus test positive 12.46 11.40 3 374650 0 64124079
Pericarditis lupus 12.46 11.40 3 374650 0 64124079
Meningitis coccidioides 12.46 11.40 6 374647 44 64124035
Jejunal stenosis 12.45 11.40 7 374646 73 64124006
Blood pH decreased 12.41 11.40 5 374648 4397 64119682
Hypoventilation 12.39 11.40 10 374643 5996 64118083
Progressive multifocal leukoencephalopathy 12.39 11.40 59 374594 18173 64105906
Dysphonia 12.38 11.40 192 374461 46190 64077889
Genital abscess 12.31 11.40 9 374644 152 64123927
Cytomegalovirus viraemia 12.24 11.40 28 374625 10800 64113279
Nasal septum disorder 12.22 11.40 8 374645 112 64123967
Ischaemic cardiomyopathy 12.20 11.40 13 374640 6825 64117254
Abnormal loss of weight 12.19 11.40 15 374638 7385 64116694
Eye irritation 12.18 11.40 49 374604 15807 64108272
Bladder cancer 12.17 11.40 107 374546 10867 64113212
Deafness 12.14 11.40 60 374593 18299 64105780
Gastrointestinal stoma output abnormal 12.13 11.40 6 374647 47 64124032
Musculoskeletal chest pain 12.11 11.40 74 374579 21405 64102674
Gastrointestinal toxicity 12.10 11.40 8 374645 5314 64118765
Crepitations 12.06 11.40 17 374636 7898 64116181
Multiple system atrophy 12.06 11.40 13 374640 374 64123705
Blood sodium increased 12.06 11.40 5 374648 4321 64119758
Food poisoning 12.05 11.40 46 374607 3432 64120647
Lymphomatoid papulosis 12.05 11.40 12 374641 314 64123765
Gastrointestinal obstruction 12.04 11.40 26 374627 1399 64122680
Human anti-human antibody test 12.03 11.40 13 374640 375 64123704
Impetigo 12.01 11.40 30 374623 1776 64122303
Elbow operation 12.00 11.40 11 374642 259 64123820
Vasculitis necrotising 12.00 11.40 22 374631 1050 64123029
Facial pain 11.99 11.40 17 374636 7878 64116201
Brain neoplasm benign 11.97 11.40 9 374644 159 64123920
Diabetic neuropathy 11.97 11.40 9 374644 5592 64118487
Vasculitis 11.92 11.40 159 374494 17936 64106143
Injection site haematoma 11.89 11.40 4 374649 3932 64120147
Hepatocellular carcinoma 11.89 11.40 19 374634 8384 64115695
Duodenitis 11.82 11.40 13 374640 6728 64117351
Anticipatory anxiety 11.82 11.40 11 374642 264 64123815
Bartholinitis 11.80 11.40 5 374648 26 64124053
Burn infection 11.80 11.40 5 374648 26 64124053
Candida infection 11.78 11.40 121 374532 31298 64092781
Transaminases increased 11.77 11.40 185 374468 44409 64079670
Hordeolum 11.75 11.40 34 374619 2198 64121881
Ischaemia 11.73 11.40 15 374638 7263 64116816
Blood thyroid stimulating hormone decreased 11.71 11.40 8 374645 5222 64118857
Gastric perforation 11.70 11.40 3 374650 3520 64120559
Peripheral vascular disorder 11.67 11.40 15 374638 7246 64116833
Adhesiolysis 11.66 11.40 4 374649 10 64124069
Refusal of treatment by patient 11.66 11.40 19 374634 8320 64115759
Pregnancy 11.62 11.40 178 374475 20687 64103392
Hypersomnia 11.61 11.40 67 374586 19650 64104429
Glioma 11.61 11.40 15 374638 525 64123554
Coronary artery aneurysm 11.58 11.40 8 374645 123 64123956
Anorectal discomfort 11.56 11.40 40 374613 2845 64121234
Oesophageal adenocarcinoma 11.55 11.40 18 374635 751 64123328
Thoracic vertebral fracture 11.55 11.40 6 374647 4547 64119532
Klebsiella infection 11.54 11.40 39 374614 13242 64110837
Bedridden 11.54 11.40 26 374627 10083 64113996
Aortic valve incompetence 11.53 11.40 19 374634 8282 64115797
Ileocaecal resection 11.52 11.40 6 374647 53 64124026
Retroperitoneal haemorrhage 11.50 11.40 7 374646 4861 64119218
Adenosquamous cell lung cancer 11.50 11.40 5 374648 28 64124051
Tuberculosis of genitourinary system 11.50 11.40 5 374648 28 64124051
Ileocolectomy 11.50 11.40 5 374648 28 64124051
Alcohol abuse 11.44 11.40 7 374646 4845 64119234
Appendicectomy 11.43 11.40 33 374620 2130 64121949
Demyelinating polyneuropathy 11.42 11.40 26 374627 1450 64122629
Hepatitis 11.40 11.40 191 374462 45391 64078688

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AB02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Tumor necrosis factor alpha (TNF-alpha) inhibitors
FDA MoA N0000175451 Tumor Necrosis Factor Receptor Blocking Activity
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D000079424 Tumor Necrosis Factor Inhibitors
FDA EPC N0000175610 Tumor Necrosis Factor Blocker

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Ulcerative colitis indication 64766004 DOID:8577
Rheumatoid arthritis indication 69896004 DOID:7148
Plaque psoriasis indication 200965009
Pustular psoriasis indication 200973000
Erythrodermic psoriasis indication 200977004
Behcet's disease indication 310701003 DOID:13241




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tumor necrosis factor Cytokine ANTIBODY BINDING UNKNOWN DRUG LABEL

External reference:

IDSource
D02598 KEGG_DRUG
4021126 VUID
N0000148580 NUI
4021126 VANDF
4036143 VANDF
CHEMBL1201581 ChEMBL_ID
5004 IUPHAR_LIGAND_ID
7602 INN_ID
DB00065 DRUGBANK_ID
B72HH48FLU UNII
1790539 RXNORM
11846 MMSL
230325 MMSL
33395 MMSL
33397 MMSL
353325 MMSL
7489 MMSL
d04342 MMSL
108675009 SNOMEDCT_US
386891004 SNOMEDCT_US
D000069285 MESH_DESCRIPTOR_UI
C0666743 UMLSCUI
007640 NDDF
016773 NDDF
017837 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Renflexis HUMAN PRESCRIPTION DRUG LABEL 1 0006-4305 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 29 sections
INFLECTRA HUMAN PRESCRIPTION DRUG LABEL 1 0069-0809 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 33 sections
INFLECTRA HUMAN PRESCRIPTION DRUG LABEL 1 0069-0809 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 33 sections
AVSOLA HUMAN PRESCRIPTION DRUG LABEL 1 55513-670 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 33 sections
REMICADE HUMAN PRESCRIPTION DRUG LABEL 1 57894-030 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 31 sections
REMICADE HUMAN PRESCRIPTION DRUG LABEL 1 57894-030 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 31 sections
INFLIXIMAB HUMAN PRESCRIPTION DRUG LABEL 1 57894-160 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 32 sections
Renflexis HUMAN PRESCRIPTION DRUG LABEL 1 78206-162 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS BLA 30 sections