certolizumab pegol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
humanized origin 4968 428863-50-7

Description:

MoleculeDescription

Synonyms:

  • certolizumab pegol
  • cimzia
  • certolizumab
A polyethylene-glycolated Fab' fragment of TUMOR NECROSIS FACTOR antibody that binds specifically to TNF-ALPHA and neutralises it in a dose-dependent manner. It also inhibits the production of lipopolysaccharide-induced TNF-ALPHA and IL-1 BETA and is used to treat RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
14 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 1, 2009 EMA
April 22, 2008 FDA UCB INC
Dec. 25, 2012 PMDA UCB Japan Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 3656.04 19.04 12031 290146 1032734 62154111
Pemphigus 3468.64 19.04 4316 297861 179410 63007435
Systemic lupus erythematosus 3195.21 19.04 4425 297752 204493 62982352
Contraindicated product administered 3137.45 19.04 4481 297696 213167 62973678
Glossodynia 2923.70 19.04 3914 298263 174962 63011883
Hand deformity 2461.68 19.04 3395 298782 156062 63030783
Maternal exposure during pregnancy 2431.34 19.04 4007 298170 216055 62970790
Alopecia 2393.84 19.04 5079 297098 332457 62854388
Swelling 2322.81 19.04 4455 297722 270923 62915922
Abdominal discomfort 2229.12 19.04 4789 297388 316096 62870749
Arthropathy 2168.23 19.04 3950 298227 230842 62956003
Drug intolerance 2114.13 19.04 4581 297596 304080 62882765
Synovitis 2031.64 19.04 3380 298797 183538 63003307
Joint swelling 1971.43 19.04 4619 297558 323047 62863798
Wound 1960.05 19.04 3089 299088 160174 63026671
Therapeutic product effect decreased 1870.37 19.04 3319 298858 189868 62996977
Anti-cyclic citrullinated peptide antibody positive 1820.03 19.04 2493 299684 113719 63073126
Pericarditis 1617.91 19.04 2518 299659 129061 63057784
Pain 1525.69 19.04 7249 294928 733379 62453466
Discomfort 1515.31 19.04 2794 299383 164580 63022265
Hypersensitivity 1502.98 19.04 3885 298292 288800 62898045
Treatment failure 1336.67 19.04 2934 299243 196109 62990736
Folliculitis 1153.83 19.04 1544 300633 68773 63118072
Muscle injury 1143.60 19.04 1481 300696 63864 63122981
Rash 1087.78 19.04 5402 296775 555469 62631376
Irritable bowel syndrome 1072.40 19.04 1620 300557 80792 63106053
Duodenal ulcer perforation 1061.38 19.04 1662 300515 85547 63101298
Rheumatoid factor positive 1055.73 19.04 1629 300548 82777 63104068
Helicobacter infection 1031.71 19.04 1697 300480 91088 63095757
Hepatic enzyme increased 1023.77 19.04 2673 299504 199655 62987190
Lower respiratory tract infection 1015.80 19.04 2061 300116 130246 63056599
Acute kidney injury 1010.69 19.04 61 302116 263354 62923491
Product use issue 990.32 19.04 2788 299389 217732 62969113
Drug interaction 984.57 19.04 22 302155 229109 62957736
Blister 983.33 19.04 2011 300166 127803 63059042
Toxicity to various agents 970.97 19.04 50 302127 247200 62939645
Anaemia 937.19 19.04 140 302037 293290 62893555
Maternal exposure before pregnancy 921.16 19.04 527 301650 7076 63179769
Hypotension 920.83 19.04 109 302068 272495 62914350
Rheumatoid arthritis 918.51 19.04 2974 299203 250845 62936000
Ill-defined disorder 878.90 19.04 1473 300704 80282 63106563
Sleep disorder due to general medical condition, insomnia type 847.85 19.04 1141 301036 51076 63135769
Impaired healing 835.56 19.04 1638 300539 100904 63085941
Death 824.17 19.04 376 301801 374005 62812840
Infection 813.31 19.04 2668 299509 226505 62960340
Fall 804.90 19.04 433 301744 391901 62794944
Infusion related reaction 783.15 19.04 2758 299419 242763 62944082
Constipation 637.15 19.04 145 302032 224798 62962047
Gastrointestinal disorder 593.82 19.04 1665 300512 129574 63057271
Rheumatic fever 575.42 19.04 858 301319 42253 63144592
Arthralgia 564.93 19.04 4630 297547 565080 62621765
Thrombocytopenia 561.74 19.04 41 302136 151116 63035729
Sinusitis 536.34 19.04 2318 299859 224335 62962510
Febrile neutropenia 518.03 19.04 9 302168 118440 63068405
Psoriatic arthropathy 513.98 19.04 1259 300918 90261 63096584
Neutropenia 509.29 19.04 106 302071 174899 63011946
Stomatitis 499.42 19.04 1624 300553 137101 63049744
Peripheral swelling 491.26 19.04 2531 299646 263411 62923434
Maternal exposure during breast feeding 474.02 19.04 279 301898 3962 63182883
Musculoskeletal stiffness 473.09 19.04 1935 300242 182683 63004162
Hip arthroplasty 471.69 19.04 828 301349 46818 63140027
Dehydration 468.79 19.04 123 302054 173231 63013614
Swollen joint count increased 457.61 19.04 701 301476 35353 63151492
Hyponatraemia 450.69 19.04 19 302158 111881 63074964
Seizure 430.61 19.04 60 302117 132574 63054271
Cough 424.98 19.04 460 301717 292283 62894562
Blood iron abnormal 420.16 19.04 250 301927 3626 63183219
Knee arthroplasty 411.33 19.04 841 301336 53365 63133480
Tremor 408.38 19.04 69 302108 132170 63054675
Nausea 405.75 19.04 2400 299777 852071 62334774
Haemoglobin decreased 405.37 19.04 97 302080 145388 63041457
Disease progression 399.77 19.04 55 302122 122703 63064142
Platelet count decreased 382.97 19.04 50 302127 116072 63070773
Renal failure 375.45 19.04 56 302121 117596 63069249
Dizziness 370.08 19.04 949 301228 428976 62757869
Oxygen saturation decreased 367.19 19.04 12 302165 88573 63098272
Nasopharyngitis 366.15 19.04 2264 299913 251993 62934852
Cardiac arrest 362.04 19.04 19 302158 92526 63094319
Pancytopenia 360.89 19.04 26 302151 96907 63089938
Somnolence 358.78 19.04 202 301975 178483 63008362
Respiratory failure 350.37 19.04 38 302139 101820 63085025
Pulmonary embolism 347.06 19.04 67 302110 116617 63070228
White blood cell count decreased 341.05 19.04 118 302059 138986 63047859
Tachycardia 336.66 19.04 75 302102 118081 63068764
Intentional overdose 331.21 19.04 4 302173 74148 63112697
Hypokalaemia 329.85 19.04 50 302127 103754 63083091
Neuropathy peripheral 326.18 19.04 71 302106 113596 63073249
Liver injury 324.29 19.04 818 301359 59702 63127143
Drug abuse 323.51 19.04 4 302173 72514 63114331
Type 2 diabetes mellitus 323.37 19.04 845 301332 63023 63123822
Anxiety 320.93 19.04 337 301840 217204 62969641
Sepsis 314.79 19.04 168 302009 152955 63033890
Fatigue 314.03 19.04 5943 296234 882085 62304760
Renal impairment 296.28 19.04 36 302141 88319 63098526
Overdose 293.73 19.04 91 302086 114987 63071858
Product availability issue 288.74 19.04 202 301975 3919 63182926
Weight decreased 286.22 19.04 552 301625 276246 62910599
Cardiac failure congestive 285.85 19.04 48 302129 92385 63094460
Bradycardia 283.41 19.04 16 302161 73211 63113634
Cardiac failure 278.54 19.04 45 302132 89097 63097748
Gastrointestinal haemorrhage 274.85 19.04 32 302145 81144 63105701
Coma 273.04 19.04 7 302170 64357 63122488
Cerebrovascular accident 271.11 19.04 88 302089 107936 63078909
Cardio-respiratory arrest 268.84 19.04 3 302174 59956 63126889
Depressed level of consciousness 266.22 19.04 6 302171 62072 63124773
Balance disorder 262.93 19.04 43 302134 84379 63102466
Myalgia 262.07 19.04 189 301988 146340 63040505
Mobility decreased 261.86 19.04 1207 300970 119952 63066893
Blood cholesterol increased 260.14 19.04 1010 301167 93022 63093823
Loss of personal independence in daily activities 259.45 19.04 1033 301144 96257 63090588
Electrocardiogram QT prolonged 258.28 19.04 5 302172 59525 63127320
Adverse event 257.52 19.04 807 301370 66752 63120093
Blood pressure increased 255.14 19.04 237 301940 161825 63025020
Pregnancy 249.80 19.04 546 301631 36290 63150555
Dysphagia 248.79 19.04 58 302119 88527 63098318
Dyspnoea 248.78 19.04 1987 300190 659326 62527519
Syncope 248.35 19.04 124 302053 117261 63069584
Chest discomfort 246.82 19.04 107 302070 109862 63076983
Night sweats 245.19 19.04 644 301533 48170 63138675
Neutrophil count decreased 243.66 19.04 5 302172 56401 63130444
Diarrhoea 242.91 19.04 2208 299969 713158 62473687
Hyperkalaemia 241.73 19.04 3 302174 54200 63132645
Gastrooesophageal reflux disease 241.61 19.04 77 302100 95562 63091283
Suicide attempt 236.71 19.04 13 302164 60905 63125940
Deep vein thrombosis 235.08 19.04 55 302122 83745 63103100
Hypoglycaemia 232.83 19.04 13 302164 60052 63126793
Therapeutic product effect incomplete 231.62 19.04 1192 300985 123864 63062981
Agitation 231.43 19.04 13 302164 59744 63127101
Hypoxia 228.54 19.04 14 302163 59778 63127067
Hallucination 221.71 19.04 9 302168 54808 63132037
Flushing 219.29 19.04 45 302132 75042 63111803
Oedema peripheral 214.59 19.04 357 301820 189154 62997691
Feeling abnormal 209.76 19.04 238 301939 148154 63038691
COVID-19 immunisation 208.79 19.04 121 302056 1666 63185179
C-reactive protein abnormal 207.37 19.04 584 301593 45512 63141333
Hyperhidrosis 206.35 19.04 129 302048 107707 63079138
Heart rate increased 206.29 19.04 95 302082 94143 63092702
Asthenia 204.34 19.04 1035 301142 382569 62804276
Multiple organ dysfunction syndrome 203.47 19.04 18 302159 56734 63130111
Pulmonary oedema 203.41 19.04 15 302162 54858 63131987
Blood pressure decreased 202.73 19.04 33 302144 64989 63121856
Therapy interrupted 202.08 19.04 465 301712 31990 63154855
International normalised ratio increased 200.99 19.04 4 302173 46421 63140424
Cognitive disorder 199.30 19.04 18 302159 55797 63131048
Epistaxis 197.62 19.04 51 302126 72674 63114171
Depression 196.81 19.04 399 301778 196093 62990752
Chills 196.56 19.04 151 302026 113227 63073618
Pleural effusion 196.34 19.04 99 302078 93111 63093734
Chest pain 196.14 19.04 463 301714 215496 62971349
Muscle spasticity 191.79 19.04 360 301817 21434 63165411
Suicidal ideation 189.51 19.04 34 302143 62387 63124458
Palpitations 189.45 19.04 155 302022 112615 63074230
Dyspnoea exertional 189.37 19.04 30 302147 60272 63126573
Vision blurred 188.64 19.04 101 302076 91823 63095022
Blood creatinine increased 186.99 19.04 92 302085 87752 63099093
Foot deformity 186.74 19.04 411 301766 27442 63159403
Vomiting 186.26 19.04 1735 300442 557882 62628963
Mucosal inflammation 182.37 19.04 10 302167 46918 63139927
Rhabdomyolysis 181.95 19.04 6 302171 43945 63142900
Chronic kidney disease 178.54 19.04 9 302168 45389 63141456
Lethargy 177.84 19.04 27 302150 55980 63130865
Ear pain 174.78 19.04 470 301707 35648 63151197
Pruritus 174.70 19.04 2549 299628 358904 62827941
Adverse drug reaction 172.79 19.04 795 301382 78919 63107926
Bone erosion 170.24 19.04 304 301873 17413 63169432
Heart rate decreased 170.18 19.04 12 302165 45548 63141297
Pneumonia 165.58 19.04 1385 300792 455382 62731463
Metabolic acidosis 165.13 19.04 13 302164 45056 63141789
Encephalopathy 164.56 19.04 4 302173 38616 63148229
General physical health deterioration 164.30 19.04 1571 300606 199831 62987014
Intentional product use issue 164.19 19.04 1107 301070 126785 63060060
Hyperglycaemia 162.45 19.04 9 302168 41858 63144987
Blood bilirubin increased 161.59 19.04 3 302174 37137 63149708
Body temperature increased 159.32 19.04 463 301714 36729 63150116
Neoplasm progression 158.26 19.04 3 302174 36425 63150420
Drug tolerance decreased 156.72 19.04 291 301886 17182 63169663
Injection site discolouration 156.45 19.04 190 301987 7658 63179187
Breast feeding 155.57 19.04 78 302099 787 63186058
Pulmonary hypertension 153.91 19.04 5 302172 37118 63149727
Bone pain 152.96 19.04 36 302141 54605 63132240
Osteonecrosis of jaw 152.15 19.04 3 302174 35120 63151725
Plasma cell myeloma 151.92 19.04 4 302173 35901 63150944
Blood glucose increased 151.05 19.04 107 302070 83649 63103196
Productive cough 149.12 19.04 57 302120 63151 63123694
No adverse event 149.00 19.04 485 301692 40920 63145925
Ascites 148.51 19.04 12 302165 40716 63146129
Leukopenia 148.48 19.04 92 302085 77198 63109647
Contusion 148.45 19.04 1221 300956 148823 63038022
Hepatic failure 147.13 19.04 5 302172 35651 63151194
Disorientation 145.61 19.04 11 302166 39441 63147404
Grip strength decreased 143.93 19.04 324 301853 21963 63164882
Unresponsive to stimuli 142.21 19.04 4 302173 33812 63153033
Wrong technique in product usage process 140.90 19.04 60 302117 62280 63124565
Rheumatoid nodule 139.44 19.04 274 301903 16881 63169964
Mental status changes 138.12 19.04 14 302163 39585 63147260
Dyskinesia 137.57 19.04 3 302174 31999 63154846
Atrial fibrillation 137.33 19.04 214 301963 116422 63070423
Septic shock 137.00 19.04 73 302104 66556 63120289
Respiratory arrest 136.77 19.04 4 302173 32641 63154204
Fibromyalgia 135.47 19.04 747 301430 79673 63107172
Dysarthria 134.67 19.04 21 302156 42690 63144155
Orthostatic hypotension 133.69 19.04 10 302167 36150 63150695
Condition aggravated 131.27 19.04 2663 299514 399554 62787291
Lymphocyte count decreased 129.43 19.04 3 302174 30254 63156591
Pneumonia aspiration 129.29 19.04 9 302168 34531 63152314
Acute respiratory failure 129.04 19.04 9 302168 34476 63152369
Urinary tract infection 128.66 19.04 736 301441 263948 62922897
Hypophagia 126.85 19.04 5 302172 31254 63155591
Asthma 126.83 19.04 260 301917 127301 63059544
Dysgeusia 126.43 19.04 33 302144 46677 63140168
Angioedema 125.86 19.04 36 302141 47929 63138916
Full blood count abnormal 125.64 19.04 6 302171 31711 63155134
Decreased appetite 125.32 19.04 692 301485 250360 62936485
Blood alkaline phosphatase increased 124.93 19.04 26 302151 42941 63143904
Disturbance in attention 124.53 19.04 17 302160 38172 63148673
Respiratory disorder 121.52 19.04 436 301741 38646 63148199
Dysphonia 120.82 19.04 38 302139 47576 63139269
Emotional distress 120.34 19.04 9 302168 32540 63154305
Haemorrhage 118.10 19.04 72 302105 60950 63125895
Thrombosis 117.72 19.04 82 302095 64673 63122172
Urinary retention 116.07 19.04 7 302170 30294 63156551
Alanine aminotransferase increased 115.98 19.04 197 301980 103573 63083272
Liver function test abnormal 112.74 19.04 44 302133 48137 63138708
Joint stiffness 112.69 19.04 446 301731 41423 63145422
Muscle spasms 112.60 19.04 374 301803 155776 63031069
Myocardial infarction 112.23 19.04 189 301988 99704 63087141
Urticaria 112.14 19.04 1245 300932 164557 63022288
Haematocrit decreased 111.95 19.04 25 302152 39315 63147530
Red blood cell sedimentation rate increased 111.60 19.04 460 301717 43522 63143323
Presyncope 110.89 19.04 5 302172 27780 63159065
Blood creatine phosphokinase increased 110.86 19.04 9 302168 30421 63156424
Colitis microscopic 109.30 19.04 175 302002 9164 63177681
Respiratory distress 108.63 19.04 16 302161 33935 63152910
Intentional self-injury 108.16 19.04 3 302174 25684 63161161
Injection site reaction 107.67 19.04 557 301620 57967 63128878
Transient ischaemic attack 107.41 19.04 24 302153 37729 63149116
Cardiac disorder 106.95 19.04 54 302123 50762 63136083
Aphasia 106.87 19.04 15 302162 32985 63153860
Pain in jaw 106.36 19.04 37 302140 43459 63143386
Onychomycosis 105.96 19.04 158 302019 7774 63179071
Speech disorder 105.67 19.04 31 302146 40598 63146247
Jaundice 105.60 19.04 9 302168 29242 63157603
Chronic obstructive pulmonary disease 105.45 19.04 86 302091 62600 63124245
Melaena 105.22 19.04 11 302166 30354 63156491
Aspartate aminotransferase increased 104.97 19.04 167 302010 90110 63096735
Fluid retention 104.04 19.04 79 302098 59607 63127238
Pericardial effusion 103.87 19.04 11 302166 30047 63156798
Full blood count decreased 102.84 19.04 5 302172 26019 63160826
Tinnitus 102.68 19.04 22 302155 35606 63151239
Cerebral haemorrhage 101.82 19.04 13 302164 30716 63156129
Arrhythmia 101.23 19.04 28 302149 38112 63148733
Cholestasis 101.13 19.04 11 302166 29423 63157422
Blood potassium decreased 100.63 19.04 37 302140 41989 63144856
Sleep apnoea syndrome 99.81 19.04 11 302166 29122 63157723
Rhinorrhoea 99.51 19.04 99 302078 65478 63121367
Altered state of consciousness 99.21 19.04 5 302172 25225 63161620
Hepatic function abnormal 99.08 19.04 27 302150 37115 63149730
Agranulocytosis 98.77 19.04 5 302172 25129 63161716
Feeling hot 98.02 19.04 59 302118 50295 63136550
Femur fracture 97.91 19.04 38 302139 41718 63145127
Coronary artery disease 97.48 19.04 18 302159 32359 63154486
Pulmonary fibrosis 96.81 19.04 411 301766 39398 63147447
Cholelithiasis 96.54 19.04 44 302133 43881 63142964
Acute myocardial infarction 96.42 19.04 18 302159 32106 63154739
Vertigo 96.05 19.04 86 302091 59801 63127044
Blood urea increased 95.55 19.04 8 302169 26371 63160474
Sinus tachycardia 94.83 19.04 5 302172 24263 63162582
Drug level increased 94.47 19.04 3 302174 22733 63164112
Restlessness 93.95 19.04 14 302163 29439 63157406
Urinary incontinence 93.85 19.04 19 302158 31995 63154850
Haematemesis 93.54 19.04 16 302161 30396 63156449
Nasal congestion 93.06 19.04 105 302072 65555 63121290
Irritability 92.51 19.04 19 302158 31675 63155170
Glaucoma 92.44 19.04 247 301930 18658 63168187
Hepatocellular injury 92.15 19.04 11 302166 27370 63159475
Generalised tonic-clonic seizure 92.08 19.04 14 302163 29002 63157843
Pallor 92.02 19.04 17 302160 30551 63156294
Stevens-Johnson syndrome 91.95 19.04 7 302170 24943 63161902
Blood sodium decreased 91.71 19.04 6 302171 24246 63162599
Shock 91.16 19.04 5 302172 23458 63163387
Hot flush 90.09 19.04 67 302110 51092 63135753
Accidental exposure to product 89.83 19.04 12 302165 27393 63159452
Rectal haemorrhage 89.23 19.04 62 302115 48968 63137877
Blood pressure fluctuation 89.13 19.04 55 302122 46262 63140583
Erythema 88.99 19.04 482 301695 175269 63011576
Eosinophilia 87.95 19.04 5 302172 22751 63164094
Systemic lupus erythematosus rash 87.54 19.04 78 302099 2174 63184671
Throat irritation 87.06 19.04 35 302142 37612 63149233
Blood lactate dehydrogenase increased 86.59 19.04 6 302171 23110 63163735
Off label use 86.49 19.04 3979 298198 670483 62516362
Haemoptysis 86.42 19.04 16 302161 28710 63158135
Weight increased 86.35 19.04 1731 300446 259061 62927784
Blood calcium decreased 85.71 19.04 12 302165 26439 63160406
Joint dislocation 85.32 19.04 239 301938 18561 63168284
Gamma-glutamyltransferase increased 84.86 19.04 28 302149 34003 63152842
Haematoma 84.48 19.04 30 302147 34790 63152055
Red blood cell count decreased 84.33 19.04 44 302133 40601 63146244
Leukocytosis 83.49 19.04 12 302165 25923 63160922
Ejection fraction decreased 83.06 19.04 6 302171 22326 63164519
Head injury 82.98 19.04 15 302162 27381 63159464
Pustular psoriasis 82.62 19.04 106 302071 4520 63182325
Hypercholesterolaemia 82.31 19.04 256 301921 21078 63165767
Skin exfoliation 81.82 19.04 52 302125 43050 63143795
Hemiparesis 81.80 19.04 8 302169 23274 63163571
Obstructive airways disorder 81.72 19.04 4 302173 20695 63166150
Dry skin 81.68 19.04 90 302087 56797 63130048
Red blood cell sedimentation rate 81.67 19.04 108 302069 4746 63182099
Muscular weakness 81.51 19.04 303 301874 122050 63064795
Transaminases increased 81.45 19.04 24 302153 31343 63155502
Depressed mood 81.20 19.04 45 302132 40146 63146699
Tenosynovitis 80.78 19.04 193 301984 13602 63173243
Live birth 80.58 19.04 287 301890 25343 63161502
Psoriasis 80.30 19.04 697 301480 86260 63100585
Prescribed overdose 80.27 19.04 349 301828 33804 63153041
Psychotic disorder 80.25 19.04 13 302164 25699 63161146
Swollen tongue 79.42 19.04 33 302144 34767 63152078
Ventricular tachycardia 78.43 19.04 4 302173 19975 63166870
Metastases to liver 78.32 19.04 10 302167 23629 63163216
Haematuria 78.14 19.04 21 302156 29136 63157709
Proteinuria 77.89 19.04 3 302174 19142 63167703
Pneumonitis 77.84 19.04 35 302142 35187 63151658
Drug dependence 77.27 19.04 12 302165 24471 63162374
Metastases to bone 77.17 19.04 6 302171 21013 63165832
Macular degeneration 76.81 19.04 12 302165 24364 63162481
Enthesopathy 76.67 19.04 143 302034 8471 63178374
Abnormal behaviour 76.24 19.04 7 302170 21419 63165426
Pancreatitis acute 75.83 19.04 18 302159 27148 63159697
Hip fracture 75.72 19.04 23 302154 29451 63157394
Aggression 75.35 19.04 11 302166 23487 63163358
Nail disorder 75.05 19.04 181 301996 12834 63174011
Hypothyroidism 74.85 19.04 56 302121 42576 63144269
Heart rate irregular 73.05 19.04 10 302167 22411 63164434
Visual acuity reduced 72.88 19.04 9 302168 21817 63165028
Angina pectoris 72.83 19.04 26 302151 30052 63156793
Renal disorder 72.51 19.04 33 302144 32941 63153904
Coagulopathy 72.34 19.04 7 302170 20537 63166308
Disseminated intravascular coagulation 71.20 19.04 5 302172 19046 63167799
Circulatory collapse 70.97 19.04 10 302167 21928 63164917
Back pain 70.91 19.04 860 301317 263285 62923560
Lower limb fracture 70.89 19.04 265 301912 23956 63162889
Product label confusion 70.61 19.04 63 302114 1759 63185086
Onychomadesis 70.50 19.04 111 302066 5729 63181116
Upper gastrointestinal haemorrhage 70.30 19.04 5 302172 18847 63167998
Crying 70.23 19.04 13 302164 23330 63163515
Nervousness 69.70 19.04 30 302147 30949 63155896
Hypoacusis 69.42 19.04 15 302162 24136 63162709
Abdominal pain 69.05 19.04 982 301195 292474 62894371
Adjustment disorder with depressed mood 68.87 19.04 151 302026 10053 63176792
Lymphopenia 67.94 19.04 5 302172 18322 63168523
Complication associated with device 67.94 19.04 3 302174 16975 63169870
Device issue 67.89 19.04 15 302162 23766 63163079
Cyanosis 67.74 19.04 3 302174 16932 63169913
Lip dry 67.60 19.04 194 301983 15276 63171569
Deep vein thrombosis postoperative 67.59 19.04 160 302017 11209 63175636
Blood pressure diastolic decreased 67.55 19.04 13 302164 22693 63164152
Withdrawal syndrome 67.38 19.04 8 302169 19989 63166856
Exostosis 66.76 19.04 212 301965 17650 63169195
Dysuria 66.41 19.04 39 302138 33699 63153146
Feeling cold 66.34 19.04 16 302161 23872 63162973
Product administration error 66.26 19.04 13 302164 22384 63164461
Facet joint syndrome 65.95 19.04 165 302012 11973 63174872
Acute myeloid leukaemia 65.56 19.04 4 302173 17143 63169702
X-ray abnormal 65.26 19.04 129 302048 7981 63178864
Blood parathyroid hormone decreased 65.08 19.04 144 302033 9647 63177198
Acute respiratory distress syndrome 64.89 19.04 16 302161 23518 63163327
Pancreatitis 64.67 19.04 83 302094 48972 63137873
Confusional state 64.48 19.04 1526 300651 234854 62951991
SARS-CoV-2 test negative 64.24 19.04 36 302141 463 63186382
Inflammation 64.15 19.04 636 301541 81637 63105208
Diplopia 63.76 19.04 17 302160 23711 63163134
Restless legs syndrome 63.47 19.04 7 302170 18524 63168321
Injury 63.45 19.04 579 301598 72668 63114177
Haematochezia 63.23 19.04 98 302079 53446 63133399
Mitral valve incompetence 63.23 19.04 9 302168 19585 63167260
Abdominal distension 62.71 19.04 207 301970 86408 63100437
Skin lesion 62.64 19.04 34 302143 30687 63156158
Anti-cyclic citrullinated peptide antibody 62.42 19.04 114 302063 6644 63180201
Panic attack 61.93 19.04 15 302162 22316 63164529
Flatulence 61.68 19.04 45 302132 34657 63152188
Oral pain 61.53 19.04 29 302148 28365 63158480
Infusion site pain 61.42 19.04 5 302172 16864 63169981
Blindness 61.31 19.04 14 302163 21685 63165160
Lupus-like syndrome 61.30 19.04 186 301991 15109 63171736
Myelodysplastic syndrome 60.90 19.04 5 302172 16749 63170096
Bedridden 60.86 19.04 151 302026 10900 63175945
Multiple sclerosis 60.86 19.04 20 302157 24352 63162493
Memory impairment 60.77 19.04 272 301905 103986 63082859
Laboratory test abnormal 60.65 19.04 26 302151 26886 63159959
Device malfunction 60.52 19.04 7 302170 17850 63168995
Retinitis 60.40 19.04 107 302070 6089 63180756
Product substitution issue 60.36 19.04 4 302173 15992 63170853
Cytomegalovirus infection 60.25 19.04 13 302164 20939 63165906
Mental disorder 60.09 19.04 24 302153 25895 63160950
Colitis 60.04 19.04 86 302091 48442 63138403
Rash maculo-papular 59.83 19.04 39 302138 31857 63154988
Diabetes mellitus inadequate control 59.47 19.04 3 302174 15123 63171722
Ankle arthroplasty 59.24 19.04 57 302120 1756 63185089
Nightmare 59.24 19.04 10 302167 19184 63167661
Insurance issue 58.76 19.04 105 302072 6016 63180829
Ischaemic stroke 58.53 19.04 8 302169 17949 63168896
Diabetic ketoacidosis 58.40 19.04 13 302164 20492 63166353
Granuloma skin 58.25 19.04 126 302051 8311 63178534
Tachypnoea 58.10 19.04 7 302170 17295 63169550
Arthrodesis 57.77 19.04 69 302108 2732 63184113
Muscle twitching 56.97 19.04 12 302165 19656 63167189
Transfusion 56.85 19.04 4 302173 15213 63171632
Blood pressure systolic increased 56.68 19.04 86 302091 47311 63139534
Drug tolerance 56.48 19.04 111 302066 6838 63180007
Deformity 56.46 19.04 152 302025 11532 63175313
Coeliac disease 56.42 19.04 161 302016 12636 63174209
Blood glucose decreased 56.32 19.04 15 302162 20937 63165908
White blood cell count increased 56.28 19.04 90 302087 48471 63138374
Loss of consciousness 55.94 19.04 331 301846 117790 63069055
Tubulointerstitial nephritis 55.92 19.04 13 302164 19890 63166955
Panniculitis 55.92 19.04 149 302028 11236 63175609
Body temperature decreased 55.66 19.04 14 302163 20305 63166540
Lip swelling 55.57 19.04 40 302137 31023 63155822
Dementia 55.41 19.04 11 302166 18783 63168062
Vaginal haemorrhage 55.21 19.04 31 302146 27456 63159389
Nerve injury 54.88 19.04 136 302041 9810 63177035
Electrolyte imbalance 54.67 19.04 14 302163 20062 63166783
Prescribed underdose 54.20 19.04 282 301895 29407 63157438
Dislocation of vertebra 54.04 19.04 124 302053 8511 63178334
Cerebral infarction 53.97 19.04 23 302154 23870 63162975
Hypocalcaemia 53.96 19.04 43 302134 31670 63155175
Rib fracture 53.92 19.04 20 302157 22577 63164268
Swelling face 53.71 19.04 141 302036 63334 63123511
Seasonal allergy 52.65 19.04 17 302160 20933 63165912
Hyperlipidaemia 52.63 19.04 14 302163 19557 63167288
Gastritis 52.48 19.04 60 302117 37243 63149602
Hepatic cytolysis 52.32 19.04 6 302171 15401 63171444
Epilepsy 52.27 19.04 32 302145 27033 63159812
Hiatus hernia 51.71 19.04 19 302158 21575 63165270
Bacteraemia 51.47 19.04 10 302167 17338 63169507
Acute hepatic failure 51.43 19.04 12 302165 18315 63168530
Bone disorder 50.68 19.04 19 302158 21307 63165538
Peritonitis 50.66 19.04 10 302167 17144 63169701
Intentional dose omission 50.59 19.04 116 302061 7959 63178886
Osteonecrosis 50.23 19.04 27 302150 24503 63162342
Subdural haematoma 50.14 19.04 5 302172 14323 63172522
Transaminases abnormal 49.84 19.04 34 302143 632 63186213
Myoclonus 49.57 19.04 8 302169 15860 63170985
Limb injury 49.37 19.04 30 302147 25447 63161398
Mental impairment 49.36 19.04 5 302172 14146 63172699
Ileus 49.34 19.04 6 302171 14719 63172126
Eye pruritus 49.00 19.04 14 302163 18657 63168188
Inability to afford medication 48.71 19.04 58 302119 2289 63184556
Myelosuppression 48.67 19.04 26 302151 23677 63163168
Peripheral venous disease 48.39 19.04 173 302004 15304 63171541
Maternal exposure timing unspecified 47.97 19.04 105 302072 6982 63179863
Joint range of motion decreased 47.91 19.04 291 301886 32137 63154708
Caesarean section 47.91 19.04 184 301993 16848 63169997
Lupus vulgaris 47.82 19.04 95 302082 5899 63180946
Metastases to central nervous system 47.39 19.04 4 302173 13101 63173744
Bronchospasm 47.16 19.04 12 302165 17268 63169577
Poor quality sleep 46.97 19.04 18 302159 19917 63166928
Sleep disorder 46.93 19.04 594 301583 80972 63105873
Hyperthyroidism 46.74 19.04 7 302170 14666 63172179
Tricuspid valve incompetence 46.52 19.04 7 302170 14614 63172231
Lacrimation increased 46.38 19.04 20 302157 20611 63166234
Drug hypersensitivity 46.34 19.04 1863 300314 308824 62878021
Twin pregnancy 46.33 19.04 41 302136 1132 63185713
Glomerular filtration rate decreased 46.23 19.04 5 302172 13436 63173409
Haemorrhoids 45.92 19.04 24 302153 22126 63164719
Skin reaction 45.59 19.04 165 302012 14684 63172161
Neuralgia 45.58 19.04 34 302143 25892 63160953
Impaired quality of life 45.26 19.04 6 302171 13777 63173068
Left ventricular dysfunction 45.23 19.04 3 302174 11985 63174860
Ageusia 45.02 19.04 6 302171 13722 63173123
Pneumothorax 44.94 19.04 11 302166 16250 63170595
Face oedema 44.80 19.04 20 302157 20192 63166653
Abdominal pain lower 44.73 19.04 34 302143 25644 63161201
Device related infection 44.70 19.04 28 302149 23364 63163481
Blood triglycerides increased 44.65 19.04 4 302173 12484 63174361
C-reactive protein increased 44.42 19.04 665 301512 94042 63092803
Polyneuropathy 44.16 19.04 8 302169 14581 63172264
Oropharyngeal pain 44.09 19.04 266 301911 94221 63092624
Eye pain 43.88 19.04 58 302119 33796 63153049
Anal abscess 43.88 19.04 79 302098 4553 63182292
Infusion site erythema 43.83 19.04 3 302174 11676 63175169
Lung infiltration 43.63 19.04 8 302169 14455 63172390
Device difficult to use 43.41 19.04 5 302172 12791 63174054
Hypermobility syndrome 43.39 19.04 34 302143 789 63186056
Supraventricular tachycardia 42.82 19.04 8 302169 14263 63172582
Paraesthesia oral 42.76 19.04 19 302158 19237 63167608
Adverse reaction 42.71 19.04 126 302051 10077 63176768
Hypophosphataemia 42.69 19.04 3 302174 11423 63175422
Sensory disturbance 42.47 19.04 7 302170 13665 63173180
Therapeutic response unexpected 42.47 19.04 18 302159 18741 63168104
Procedural pain 42.36 19.04 25 302152 21544 63165301
Neutrophil count increased 42.27 19.04 13 302164 16514 63170331
Rash macular 41.91 19.04 30 302147 23334 63163511
Cardiac murmur 41.90 19.04 9 302168 14543 63172302
Acidosis 41.83 19.04 3 302174 11230 63175615
Mania 41.54 19.04 5 302172 12362 63174483
Cardiomegaly 41.34 19.04 16 302161 17598 63169247
Cardiomyopathy 41.23 19.04 16 302161 17568 63169277
Lymphoedema 41.12 19.04 4 302173 11688 63175157
Product complaint 41.06 19.04 6 302171 12803 63174042
Toothache 41.00 19.04 20 302157 19179 63167666
Skin laceration 40.94 19.04 29 302148 22679 63164166
Throat tightness 40.79 19.04 35 302142 24852 63161993
Blood albumin decreased 40.79 19.04 10 302167 14756 63172089
Ankylosing spondylitis 40.69 19.04 126 302051 10348 63176497
COVID-19 pneumonia 40.48 19.04 9 302168 14200 63172645
Blood magnesium decreased 40.46 19.04 7 302170 13191 63173654
Sneezing 40.42 19.04 18 302159 18200 63168645
Pollakiuria 40.32 19.04 44 302133 27893 63158952
Osteopenia 40.19 19.04 22 302155 19763 63167082
Clostridium difficile colitis 40.17 19.04 24 302153 20545 63166300
Delusion 40.01 19.04 5 302172 12012 63174833
Blood pressure diastolic abnormal 39.87 19.04 10 302167 14532 63172313
Musculoskeletal disorder 39.71 19.04 199 301978 20445 63166400
Urine output decreased 39.70 19.04 4 302173 11366 63175479
Nephrolithiasis 39.51 19.04 338 301839 41646 63145199
Rash erythematous 39.44 19.04 90 302087 42420 63144425
Cellulitis 39.15 19.04 229 301948 81729 63105116
Hypoalbuminaemia 39.09 19.04 5 302172 11800 63175045
Foot operation 38.97 19.04 98 302079 7133 63179712
Coordination abnormal 38.69 19.04 9 302168 13764 63173081
Diabetes mellitus 38.61 19.04 136 302041 55674 63131171
Acute generalised exanthematous pustulosis 38.51 19.04 4 302173 11095 63175750
Faeces discoloured 38.45 19.04 20 302157 18489 63168356
Exposure during pregnancy 38.43 19.04 991 301186 154556 63032289
Sputum discoloured 38.12 19.04 15 302162 16332 63170513
Musculoskeletal chest pain 37.91 19.04 27 302150 21056 63165789
Cold sweat 37.80 19.04 6 302171 12041 63174804
Eosinophil count increased 37.76 19.04 4 302173 10924 63175921
Breast cancer metastatic 37.68 19.04 6 302171 12012 63174833
Pelvic pain 37.65 19.04 9 302168 13510 63173335
Sciatica 37.55 19.04 286 301891 34038 63152807
Extremity contracture 37.53 19.04 38 302139 1247 63185598
Aspiration 37.42 19.04 4 302173 10847 63175998
Eating disorder 37.40 19.04 22 302155 18994 63167851
Anger 37.33 19.04 7 302170 12449 63174396
Hepatomegaly 37.13 19.04 6 302171 11883 63174962
Mood altered 36.98 19.04 12 302165 14731 63172114
Paraesthesia 36.96 19.04 525 301652 156441 63030404
Skin discolouration 36.81 19.04 78 302099 37750 63149095
Bunion operation 36.63 19.04 38 302139 1284 63185561
Retching 36.60 19.04 12 302165 14633 63172212
Thinking abnormal 36.50 19.04 4 302173 10639 63176206
Dry eye 36.45 19.04 88 302089 40673 63146172
Rhinitis allergic 36.44 19.04 6 302171 11721 63175124
Tongue disorder 36.32 19.04 122 302055 10458 63176387
Splenomegaly 36.29 19.04 5 302172 11152 63175693
Oesophagitis 36.29 19.04 13 302164 14995 63171850
Rales 36.26 19.04 8 302169 12689 63174156
Respiratory rate increased 36.25 19.04 10 302167 13638 63173207
Schizophrenia 36.09 19.04 3 302174 9949 63176896
Tuberculin test positive 36.00 19.04 62 302115 3449 63183396
Decubitus ulcer 35.97 19.04 4 302173 10516 63176329
Abnormal dreams 35.95 19.04 4 302173 10512 63176333
Sudden death 35.65 19.04 4 302173 10445 63176400
Gastric ulcer 35.65 19.04 37 302140 24000 63162845
Autoimmune disorder 35.49 19.04 169 302008 17008 63169837
Skin necrosis 35.45 19.04 146 302031 13804 63173041
Myocarditis 35.11 19.04 4 302173 10321 63176524
Feeding disorder 35.10 19.04 10 302167 13352 63173493
Myocardial ischaemia 34.95 19.04 9 302168 12850 63173995
Chromaturia 34.82 19.04 18 302159 16699 63170146
Hallucination, auditory 34.81 19.04 9 302168 12815 63174030
Cardiac failure acute 34.18 19.04 3 302174 9520 63177325
Middle insomnia 34.08 19.04 9 302168 12634 63174211
Gallbladder disorder 34.05 19.04 24 302153 18818 63168027
Incontinence 33.89 19.04 7 302170 11625 63175220
Cataract 33.75 19.04 148 302029 56905 63129940
Immune thrombocytopenia 33.71 19.04 5 302172 10551 63176294
Petechiae 33.67 19.04 12 302165 13885 63172960
COVID-19 33.53 19.04 360 301817 112743 63074102
Head discomfort 33.51 19.04 11 302166 13404 63173441
Spinal compression fracture 33.48 19.04 13 302164 14270 63172575
Blood calcium increased 33.41 19.04 3 302174 9347 63177498
Emotional disorder 33.37 19.04 11 302166 13368 63173477
Drug ineffective for unapproved indication 33.35 19.04 70 302107 33993 63152852
Hemiplegia 33.29 19.04 3 302174 9320 63177525
Choking 33.17 19.04 4 302173 9875 63176970
Sinus disorder 32.93 19.04 41 302136 24512 63162333
Incorrect dose administered 32.84 19.04 160 302017 59808 63127037
Basal cell carcinoma 32.76 19.04 237 301940 27754 63159091
Metastases to lung 32.66 19.04 10 302167 12740 63174105
Malnutrition 32.57 19.04 16 302161 15282 63171563
Hepatic encephalopathy 32.44 19.04 7 302170 11275 63175570
Uveitis 32.39 19.04 132 302045 12421 63174424
Sensory loss 32.35 19.04 5 302172 10233 63176612
Disease susceptibility 32.33 19.04 17 302160 191 63186654
Pseudomonas infection 32.15 19.04 7 302170 11206 63175639
Hypokinesia 32.15 19.04 13 302164 13923 63172922
Prothrombin time prolonged 31.80 19.04 4 302173 9560 63177285
Incorrect product administration duration 31.54 19.04 8 302169 11538 63175307
Facial pain 31.52 19.04 6 302171 10555 63176290
Therapy non-responder 31.44 19.04 522 301655 75379 63111466
Chronic sinusitis 31.27 19.04 11 302166 12832 63174013
Breath sounds abnormal 31.16 19.04 7 302170 10966 63175879
Upper-airway cough syndrome 31.02 19.04 8 302169 11410 63175435
Thirst 30.95 19.04 14 302163 14027 63172818
Spinal fracture 30.80 19.04 25 302152 18246 63168599
Fear of injection 30.49 19.04 89 302088 7075 63179770
C-reactive protein 30.44 19.04 70 302107 4812 63182033
Hypoaesthesia oral 30.32 19.04 12 302165 13021 63173824
Motor dysfunction 30.29 19.04 7 302170 10754 63176091
Ventricular extrasystoles 30.24 19.04 9 302168 11678 63175167
Paranoia 30.20 19.04 9 302168 11670 63175175
Hyperthermia 30.03 19.04 4 302173 9152 63177693
Fine motor skill dysfunction 29.88 19.04 69 302108 4756 63182089
Tuberculosis 29.81 19.04 119 302058 11092 63175753
Liver function test increased 29.75 19.04 262 301915 32549 63154296
Gait inability 29.74 19.04 384 301793 52575 63134270
Influenza 29.50 19.04 353 301824 108369 63078476
Purpura 29.03 19.04 9 302168 11376 63175469
Blood iron decreased 28.99 19.04 17 302160 14704 63172141
Pulmonary toxicity 28.97 19.04 105 302072 9350 63177495
Eructation 28.92 19.04 3 302174 8330 63178515
Subarachnoid haemorrhage 28.84 19.04 16 302161 14267 63172578
Dysstasia 28.75 19.04 35 302142 21131 63165714
Renal cyst 28.41 19.04 7 302170 10295 63176550
Immobile 28.40 19.04 77 302100 5866 63180979
Diabetic eye disease 28.03 19.04 14 302163 140 63186705
Post procedural complication 28.00 19.04 24 302153 17050 63169795
Heavy menstrual bleeding 27.92 19.04 26 302151 17747 63169098
Central nervous system lesion 27.86 19.04 8 302169 10627 63176218
Intestinal perforation 27.86 19.04 11 302166 11952 63174893
Anal incontinence 27.71 19.04 15 302162 13561 63173284
Exposure via breast milk 27.51 19.04 41 302136 2016 63184829
Syringe issue 27.27 19.04 49 302128 2820 63184025
Seronegative arthritis 27.19 19.04 59 302118 3900 63182945
Eye haemorrhage 27.19 19.04 4 302173 8492 63178353
Treatment noncompliance 27.15 19.04 89 302088 37236 63149609
Amenorrhoea 26.83 19.04 7 302170 9907 63176938
Impaired gastric emptying 26.65 19.04 8 302169 10324 63176521
Toxic skin eruption 26.65 19.04 14 302163 12871 63173974
Blood pressure abnormal 26.63 19.04 20 302157 15178 63171667
Cystitis 26.61 19.04 153 302024 54838 63132007
Latent tuberculosis 26.43 19.04 46 302131 2581 63184264
Glycosylated haemoglobin increased 26.35 19.04 13 302164 12385 63174460
Cholecystitis acute 26.18 19.04 4 302173 8256 63178589
Therapy partial responder 26.17 19.04 9 302168 10649 63176196
Eye swelling 26.16 19.04 46 302131 23872 63162973
Vitamin D deficiency 26.03 19.04 17 302160 13875 63172970
Rash papular 25.84 19.04 22 302155 15680 63171165
Abdominal tenderness 25.77 19.04 4 302173 8162 63178683
Gastroenteritis 25.73 19.04 55 302122 26535 63160310
Micturition urgency 25.61 19.04 7 302170 9604 63177241
Intervertebral disc protrusion 25.57 19.04 46 302131 23663 63163182
Abortion 25.49 19.04 44 302133 2452 63184393
Disease recurrence 25.47 19.04 60 302117 27970 63158875
Aspergillus infection 25.46 19.04 4 302173 8089 63178756
Skin disorder 25.37 19.04 65 302112 29442 63157403
Epstein-Barr virus infection 25.28 19.04 4 302173 8046 63178799
Premature labour 25.26 19.04 14 302163 12490 63174355
Colitis ulcerative 25.22 19.04 54 302123 26037 63160808
Apnoea 25.16 19.04 4 302173 8018 63178827
Deafness 25.13 19.04 29 302148 17928 63168917
Wrist fracture 24.96 19.04 17 302160 13570 63173275
Lipase increased 24.94 19.04 8 302169 9892 63176953
Blood pressure systolic decreased 24.82 19.04 3 302174 7394 63179451
Scoliosis 24.59 19.04 4 302173 7884 63178961
Muscle tightness 24.51 19.04 13 302164 11887 63174958
Arteriosclerosis coronary artery 24.48 19.04 5 302172 8368 63178477
Burning sensation 24.42 19.04 155 302022 54252 63132593
Enterococcal infection 24.42 19.04 4 302173 7844 63179001
Hypersomnia 24.37 19.04 30 302147 18025 63168820
Hepatic cirrhosis 24.26 19.04 201 301976 24533 63162312
Malaise 24.25 19.04 1679 300498 414275 62772570
Dermatitis atopic 24.24 19.04 8 302169 9716 63177129
Muscle strain 24.06 19.04 5 302172 8269 63178576
Spinal osteoarthritis 23.91 19.04 25 302152 16161 63170684
Pulmonary thrombosis 23.83 19.04 6 302171 8696 63178149
Borrelia infection 23.61 19.04 15 302162 246 63186599
Concomitant disease aggravated 23.60 19.04 7 302170 9105 63177740
Cholecystitis 23.57 19.04 23 302154 15354 63171491
Breast cancer stage III 23.54 19.04 105 302072 10281 63176564
Nervous system disorder 23.47 19.04 33 302144 18733 63168112
Respiratory syncytial virus infection 23.17 19.04 3 302174 7015 63179830
Weight fluctuation 22.91 19.04 9 302168 9810 63177035
Axial spondyloarthritis 22.74 19.04 17 302160 367 63186478
Peripheral sensory neuropathy 22.74 19.04 4 302173 7447 63179398
Atrial flutter 22.73 19.04 9 302168 9763 63177082
Drug level decreased 22.59 19.04 5 302172 7914 63178931
Anosmia 22.49 19.04 3 302174 6857 63179988
Tooth loss 22.47 19.04 3 302174 6853 63179992
Normal newborn 22.36 19.04 6 302171 8335 63178510
Apathy 22.34 19.04 7 302170 8787 63178058
Platelet count increased 22.29 19.04 31 302146 17680 63169165
Pemphigoid 22.29 19.04 4 302173 7340 63179505
Genital haemorrhage 22.23 19.04 4 302173 7328 63179517
Eczema 22.13 19.04 79 302098 32212 63154633
Electrocardiogram abnormal 22.11 19.04 8 302169 9171 63177674
Diverticulum 22.03 19.04 15 302162 11976 63174869
Cerebral ischaemia 21.92 19.04 3 302174 6725 63180120
Hepatitis acute 21.88 19.04 8 302169 9112 63177733
Nail operation 21.86 19.04 24 302153 866 63185979
Drug resistance 21.72 19.04 48 302129 22885 63163960
Ecchymosis 21.58 19.04 13 302164 11081 63175764
Ulcer 21.40 19.04 204 301973 25903 63160942
Injection site pallor 21.38 19.04 9 302168 58 63186787
Gout 21.34 19.04 19 302158 13252 63173593
Skin fissures 21.25 19.04 14 302163 11374 63175471
Headache 21.23 19.04 2665 299512 630576 62556269
Small intestinal obstruction 21.23 19.04 34 302143 18303 63168542
Amnesia 21.21 19.04 166 302011 55419 63131426
Breast cancer female 21.11 19.04 20 302157 13539 63173306
Polyp 21.03 19.04 3 302174 6518 63180327
Escherichia infection 20.83 19.04 18 302159 12736 63174109
Bradyphrenia 20.76 19.04 4 302173 6976 63179869
Focal peritonitis 20.66 19.04 6 302171 9 63186836
Gastric haemorrhage 20.50 19.04 3 302174 6395 63180450
Hepatitis cholestatic 20.33 19.04 4 302173 6874 63179971
Low density lipoprotein increased 20.32 19.04 3 302174 6354 63180491
Atelectasis 20.32 19.04 45 302132 21438 63165407
Osteoarthritis 20.30 19.04 596 301581 94747 63092098
Rheumatic disorder 20.21 19.04 45 302132 3027 63183818
Alanine aminotransferase abnormal 20.18 19.04 57 302120 4447 63182398
Paralysis 20.12 19.04 11 302166 9889 63176956
Osteoporosis 20.07 19.04 384 301793 56954 63129891
Duodenal ulcer 20.02 19.04 6 302171 7750 63179095
Pain in extremity 19.97 19.04 1334 300843 330152 62856693
Haemophagocytic lymphohistiocytosis 19.92 19.04 13 302164 10614 63176231
Large intestine polyp 19.83 19.04 7 302170 8150 63178695
Stress 19.81 19.04 214 301963 66953 63119892
Ligament sprain 19.79 19.04 19 302158 12781 63174064
Limb fracture 19.74 19.04 7 302170 26 63186819
Emphysema 19.68 19.04 14 302163 10924 63175921
Temperature intolerance 19.66 19.04 9 302168 8955 63177890
Diverticulum intestinal 19.64 19.04 4 302173 6709 63180136
Failure to thrive 19.64 19.04 5 302172 7193 63179652
Nodule 19.64 19.04 169 302008 20857 63165988
Bladder disorder 19.59 19.04 9 302168 8937 63177908
Congestive cardiomyopathy 19.58 19.04 3 302174 6179 63180666
Asphyxia 19.57 19.04 3 302174 6178 63180667
Therapeutic response decreased 19.52 19.04 406 301771 61119 63125726
Dermatitis psoriasiform 19.48 19.04 37 302140 2222 63184623
Wrong product administered 19.40 19.04 3 302174 6138 63180707
Eyelid oedema 19.40 19.04 13 302164 10466 63176379
Retinal deposits 19.32 19.04 9 302168 76 63186769
Gangrene 19.32 19.04 3 302174 6120 63180725
Tenderness 19.21 19.04 50 302127 22528 63164317
Hypertransaminasaemia 19.21 19.04 4 302173 6605 63180240
Eye irritation 19.20 19.04 48 302129 21923 63164922
Immune reconstitution inflammatory syndrome 19.16 19.04 3 302174 6081 63180764

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 1323.50 19.53 1772 28280 454979 34471900
Synovitis 581.78 19.53 270 29782 13796 34913083
Treatment failure 413.09 19.53 333 29719 46364 34880515
No adverse event 362.96 19.53 233 29819 22694 34904185
Joint swelling 332.12 19.53 328 29724 59562 34867317
Maternal exposure before pregnancy 302.20 19.53 80 29972 711 34926168
Rheumatoid arthritis 301.10 19.53 255 29797 37983 34888896
Therapeutic product effect decreased 294.92 19.53 242 29810 34501 34892378
Loss of personal independence in daily activities 273.03 19.53 227 29825 32952 34893927
Maternal exposure during pregnancy 269.30 19.53 115 29937 4803 34922076
Product dose omission issue 250.16 19.53 402 29650 119309 34807570
Pain 247.11 19.53 543 29509 204132 34722747
C-reactive protein abnormal 226.18 19.53 122 29930 8588 34918291
Drug hypersensitivity 221.93 19.53 308 29744 80221 34846658
Arthropathy 216.98 19.53 182 29870 26725 34900154
Therapy interrupted 211.23 19.53 137 29915 13560 34913319
Product availability issue 210.41 19.53 74 29978 1813 34925066
Tenosynovitis 202.18 19.53 92 29960 4478 34922401
Contraindicated product administered 197.81 19.53 157 29895 21324 34905555
Enthesopathy 195.08 19.53 90 29962 4523 34922356
Musculoskeletal stiffness 191.59 19.53 218 29834 46462 34880417
Drug intolerance 188.77 19.53 244 29808 59326 34867553
Arthralgia 183.66 19.53 432 29620 169609 34757270
Red blood cell sedimentation rate abnormal 183.61 19.53 80 29972 3509 34923370
Alanine aminotransferase abnormal 178.29 19.53 85 29967 4603 34922276
Psoriasis 160.49 19.53 182 29870 38630 34888249
Ankylosing spondylitis 155.34 19.53 82 29970 5522 34921357
Toxicity to various agents 146.57 19.53 6 30046 200356 34726523
Tongue disorder 139.20 19.53 75 29977 5264 34921615
Drug interaction 138.83 19.53 16 30036 225930 34700949
Psoriatic arthropathy 135.50 19.53 122 29930 19676 34907203
Acute kidney injury 133.46 19.53 48 30004 304940 34621939
Bone erosion 120.58 19.53 62 29990 3953 34922926
Hypotension 113.21 19.53 26 30026 221623 34705256
Surgery 112.50 19.53 95 29957 14062 34912817
C-reactive protein increased 110.41 19.53 180 29872 53918 34872961
Infection 107.85 19.53 240 29812 90675 34836204
Tendonitis 104.40 19.53 76 29976 9064 34917815
Gastric disorder 101.98 19.53 85 29967 12356 34914523
Exposure via breast milk 96.97 19.53 43 30009 1967 34924912
Frequent bowel movements 95.87 19.53 83 29969 12704 34914175
Cytology abnormal 95.48 19.53 28 30024 373 34926506
Therapeutic product effect incomplete 94.88 19.53 162 29890 50379 34876500
Anti-cyclic citrullinated peptide antibody positive 94.00 19.53 41 30011 1802 34925077
Neutropenia 91.62 19.53 13 30039 156765 34770114
Mobility decreased 91.58 19.53 121 29931 30007 34896872
Confusional state 88.98 19.53 10 30042 144150 34782729
COVID-19 immunisation 88.56 19.53 24 30028 235 34926644
Physical disability 87.59 19.53 36 30016 1363 34925516
Insurance issue 86.88 19.53 40 30012 1999 34924880
Low birth weight baby 86.38 19.53 64 29988 7841 34919038
Premature baby 86.13 19.53 95 29957 19538 34907341
Knee arthroplasty 85.25 19.53 62 29990 7382 34919497
Injection site pain 82.57 19.53 132 29920 38873 34888006
Inflammation 81.95 19.53 111 29941 28184 34898695
Thrombocytopenia 74.57 19.53 21 30031 156226 34770653
Polyarthritis 73.89 19.53 47 30005 4493 34922386
Joint lock 73.72 19.53 31 30021 1244 34925635
Arthritis 73.20 19.53 111 29941 31235 34895644
Seronegative arthritis 72.83 19.53 29 30023 1010 34925869
Renal failure 71.38 19.53 13 30039 130544 34796335
Hypersensitivity 71.05 19.53 160 29892 60875 34866004
Anaemia 70.97 19.53 58 29994 233277 34693602
Pancytopenia 68.99 19.53 3 30049 95154 34831725
Prerenal failure 67.88 19.53 34 30018 2050 34924829
Nasopharyngitis 65.93 19.53 169 29883 69799 34857080
Disease progression 65.42 19.53 8 30044 108069 34818810
Completed suicide 65.37 19.53 5 30047 98163 34828716
Fine motor skill dysfunction 63.45 19.53 31 30021 1771 34925108
Drug abuse 63.38 19.53 6 30046 99090 34827789
Rash 63.09 19.53 366 29686 222386 34704493
Rheumatoid factor negative 62.70 19.53 25 30027 874 34926005
Skin mass 61.75 19.53 40 30012 3945 34922934
Hand deformity 61.71 19.53 39 30013 3686 34923193
Renal impairment 59.71 19.53 6 30046 94507 34832372
Red blood cell sedimentation rate 59.19 19.53 26 30026 1162 34925717
Joint ankylosis 58.23 19.53 28 30024 1544 34925335
Bone cyst 57.76 19.53 28 30024 1572 34925307
Granuloma skin 57.35 19.53 26 30026 1253 34925626
Abdominal pain 57.26 19.53 285 29767 163333 34763546
Tuberculosis 56.98 19.53 52 30000 8525 34918354
Abdominal abscess 55.28 19.53 38 30014 4137 34922742
Drug tolerance decreased 55.12 19.53 29 30023 1938 34924941
Peripheral swelling 54.51 19.53 167 29885 76374 34850505
Palmoplantar pustulosis 54.29 19.53 14 30038 111 34926768
Pustular psoriasis 54.06 19.53 27 30025 1618 34925261
Joint stiffness 53.64 19.53 56 29996 10817 34916062
White blood cell count decreased 53.25 19.53 9 30043 95436 34831443
Blood parathyroid hormone decreased 50.73 19.53 25 30027 1455 34925424
Herpes zoster 50.27 19.53 99 29953 34300 34892579
Injection site reaction 50.26 19.53 59 29993 12974 34913905
Dyspnoea 50.11 19.53 162 29890 376620 34550259
Panniculitis 49.16 19.53 27 30025 1967 34924912
Gastrointestinal infection 48.31 19.53 40 30012 5758 34921121
Foetal exposure during pregnancy 46.70 19.53 102 29950 37999 34888880
Latent tuberculosis 46.65 19.53 23 30029 1340 34925539
Cardiac arrest 45.70 19.53 13 30039 96146 34830733
Constipation 45.51 19.53 31 30021 136951 34789928
Skin injury 45.08 19.53 27 30025 2318 34924561
Basal cell carcinoma 43.61 19.53 68 29984 19590 34907289
Seizure 43.23 19.53 18 30034 104839 34822040
Tachycardia 43.08 19.53 10 30042 84762 34842117
Neck mass 42.99 19.53 23 30029 1590 34925289
Platelet count decreased 42.64 19.53 25 30027 119692 34807187
Osteolysis 42.50 19.53 29 30023 3119 34923760
Sinusitis 42.12 19.53 103 29949 41299 34885580
Intentional dose omission 42.01 19.53 30 30022 3470 34923409
Rheumatoid nodule 41.82 19.53 28 30024 2919 34923960
Hyponatraemia 41.54 19.53 10 30042 82681 34844198
Rhabdomyolysis 41.34 19.53 5 30047 68158 34858721
Off label use 40.82 19.53 544 29508 418980 34507899
Axial spondyloarthritis 39.99 19.53 14 30038 338 34926541
Injection site bruising 39.86 19.53 43 30009 8620 34918259
Mass 39.50 19.53 41 30011 7864 34919015
Nephrolithiasis 39.23 19.53 83 29969 30250 34896629
Asthenia 38.75 19.53 97 29955 245154 34681725
Prostate cancer 38.60 19.53 97 29955 39552 34887327
Bradycardia 38.12 19.53 9 30043 75409 34851470
Crohn's disease 38.06 19.53 27 30025 3090 34923789
Blood creatinine increased 38.04 19.53 17 30035 94959 34831920
Inflammatory bowel disease 37.30 19.53 26 30026 2894 34923985
Impaired work ability 36.55 19.53 37 30015 6893 34919986
Localised infection 36.48 19.53 59 29993 17528 34909351
Musculoskeletal pain 36.28 19.53 83 29969 31880 34894999
Pruritus 35.46 19.53 226 29826 141755 34785124
Fistula 35.12 19.53 36 30016 6804 34920075
Erythema 34.87 19.53 160 29892 88620 34838259
Product use in unapproved indication 34.68 19.53 30 30022 117469 34809410
Upper respiratory tract infection 34.42 19.53 83 29969 32976 34893903
Syncope 34.14 19.53 18 30034 91433 34835446
Skin necrosis 34.11 19.53 33 30019 5820 34921059
Therapeutic response decreased 33.14 19.53 76 29976 29237 34897642
Respiratory failure 32.92 19.53 27 30025 108545 34818334
Ill-defined disorder 32.09 19.53 49 30003 13860 34913019
Decreased appetite 31.91 19.53 59 29993 166333 34760546
Disability 31.87 19.53 29 30023 4736 34922143
Cardio-respiratory arrest 31.29 19.53 5 30047 55268 34871611
Overdose 31.05 19.53 20 30032 91039 34835840
Somnolence 30.85 19.53 30 30022 111086 34815793
Gastrointestinal haemorrhage 30.76 19.53 19 30033 88458 34838421
Hepatic fibrosis 30.73 19.53 28 30024 4579 34922300
Hallucination 30.68 19.53 4 30048 51494 34875385
Swelling 30.66 19.53 93 29959 42273 34884606
Hospitalisation 30.60 19.53 113 29939 56789 34870090
Oxygen saturation decreased 30.17 19.53 5 30047 53813 34873066
Mycobacterium tuberculosis complex test positive 30.01 19.53 17 30035 1315 34925564
Limb discomfort 29.96 19.53 42 30010 11005 34915874
Rheumatoid factor 29.93 19.53 8 30044 74 34926805
Hip arthroplasty 29.45 19.53 27 30025 4452 34922427
Rectal abscess 29.36 19.53 17 30035 1371 34925508
Hypokalaemia 29.31 19.53 7 30045 58207 34868672
Motor dysfunction 29.29 19.53 33 30019 6941 34919938
Skin ulcer 28.96 19.53 61 29991 22155 34904724
Hypoglycaemia 28.65 19.53 6 30046 54634 34872245
Oedema 28.63 19.53 3 30049 45738 34881141
Body mass index abnormal 28.60 19.53 9 30043 154 34926725
Septic shock 28.54 19.53 13 30039 71821 34855058
Blood creatine phosphokinase increased 27.92 19.53 3 30049 44854 34882025
Abscess 27.79 19.53 42 30010 11775 34915104
Maternal exposure during breast feeding 27.71 19.53 17 30035 1524 34925355
Fear of injection 27.60 19.53 17 30035 1535 34925344
Rheumatoid factor positive 27.50 19.53 13 30039 690 34926189
Multiple organ dysfunction syndrome 27.23 19.53 16 30036 76550 34850329
Anal fistula 26.97 19.53 28 30024 5371 34921508
Rheumatoid factor increased 26.91 19.53 12 30040 556 34926323
Agitation 26.82 19.53 8 30044 57391 34869488
Vomiting 26.61 19.53 116 29936 247505 34679374
Immobilisation syndrome 26.21 19.53 10 30042 310 34926569
Cardiac failure congestive 26.13 19.53 20 30032 83250 34843629
Anal abscess 26.12 19.53 30 30022 6443 34920436
Therapeutic response shortened 26.05 19.53 32 30020 7372 34919507
Dyspepsia 25.98 19.53 80 29972 36652 34890227
Ligament calcification 25.95 19.53 9 30043 211 34926668
Hepatic steatosis 25.80 19.53 52 30000 18310 34908569
Tremor 25.70 19.53 20 30032 82567 34844312
Bladder transitional cell carcinoma 25.70 19.53 20 30032 2635 34924244
Plasma cell myeloma 25.69 19.53 3 30049 42034 34884845
Sacroiliitis 25.61 19.53 16 30036 1482 34925397
Headache 25.47 19.53 274 29778 200361 34726518
Sepsis 25.40 19.53 67 29985 166494 34760385
Haematuria 25.24 19.53 6 30046 50060 34876819
Oedema peripheral 25.23 19.53 40 30012 119772 34807107
International normalised ratio increased 25.23 19.53 5 30047 47322 34879557
Folliculitis 25.22 19.53 25 30027 4541 34922338
Fall 24.99 19.53 90 29962 202795 34724084
Delirium 24.85 19.53 4 30048 43987 34882892
Injection site erythema 24.74 19.53 47 30005 15852 34911027
Atrial fibrillation 24.71 19.53 42 30010 122351 34804528
Metabolic acidosis 24.61 19.53 4 30048 43676 34883203
Balance disorder 24.60 19.53 3 30049 40651 34886228
Rheumatoid lung 23.90 19.53 13 30039 929 34925950
Perirectal abscess 23.77 19.53 16 30036 1682 34925197
Dysphagia 23.69 19.53 12 30040 62369 34864510
Hyperglycaemia 23.68 19.53 3 30049 39477 34887402
Hypoxia 23.44 19.53 9 30043 55086 34871793
Loss of consciousness 23.31 19.53 22 30030 82645 34844234
Joint range of motion decreased 23.18 19.53 30 30022 7282 34919597
Dermatitis psoriasiform 23.14 19.53 15 30037 1481 34925398
Death 23.09 19.53 225 29827 397824 34529055
Ulcer 23.08 19.53 33 30019 8802 34918077
Ascites 22.67 19.53 6 30046 46565 34880314
Metastatic bronchial carcinoma 22.45 19.53 9 30043 319 34926560
Therapy non-responder 22.10 19.53 79 29973 39067 34887812
Bradycardia foetal 21.55 19.53 9 30043 355 34926524
Pulmonary oedema 21.53 19.53 7 30045 47522 34879357
Inappropriate schedule of product administration 21.36 19.53 108 29944 62188 34864691
Pharyngitis streptococcal 21.29 19.53 18 30034 2666 34924213
Quarantine 21.20 19.53 5 30047 26 34926853
Pneumonia aspiration 21.17 19.53 5 30047 41898 34884981
Hepatic function abnormal 21.06 19.53 6 30046 44357 34882522
Acute myocardial infarction 20.90 19.53 10 30042 53709 34873170
Bronchitis 20.63 19.53 81 29971 41882 34884997
Cellulitis 20.45 19.53 95 29957 52856 34874023
Haemoglobin decreased 20.43 19.53 46 30006 120726 34806153
Mental status changes 20.34 19.53 4 30048 38079 34888800
Tendon disorder 20.22 19.53 18 30034 2857 34924022
Dysarthria 20.02 19.53 3 30049 34779 34892100
Foot deformity 19.97 19.53 22 30030 4515 34922364
Foot fracture 19.84 19.53 23 30029 4988 34921891
Injection site rash 19.79 19.53 21 30031 4132 34922747
Dizziness 19.63 19.53 109 29943 218412 34708467

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 2791.57 20.07 7693 205195 1073220 78458280
Synovitis 2738.38 20.07 2639 210249 148095 79383405
Contraindicated product administered 2662.04 20.07 2651 210237 154887 79376613
Pemphigus 2429.32 20.07 2059 210829 97523 79433977
Drug intolerance 2381.41 20.07 3214 209674 260905 79270595
Hand deformity 2326.89 20.07 2046 210842 101873 79429627
Systemic lupus erythematosus 2280.64 20.07 2164 210724 118985 79412515
Joint swelling 2198.26 20.07 3240 209648 285406 79246094
Glossodynia 2134.22 20.07 1944 210944 101393 79430107
Anti-cyclic citrullinated peptide antibody positive 2088.91 20.07 1749 211139 81394 79450106
Therapeutic product effect decreased 2063.83 20.07 2360 210528 161503 79369997
Arthropathy 1925.11 20.07 2366 210522 174745 79356755
Swelling 1863.70 20.07 2579 210309 214132 79317368
Pericarditis 1697.95 20.07 1721 211167 102515 79428985
Maternal exposure during pregnancy 1680.57 20.07 1944 210944 134594 79396906
Alopecia 1662.36 20.07 2529 210359 228826 79302674
Abdominal discomfort 1603.53 20.07 2598 210290 248129 79283371
Wound 1598.28 20.07 1753 211135 114426 79417074
Hypersensitivity 1506.81 20.07 2590 210298 259649 79271851
Treatment failure 1475.26 20.07 2036 210852 168450 79363050
Discomfort 1305.68 20.07 1642 211246 123975 79407525
Duodenal ulcer perforation 1229.83 20.07 1175 211713 65036 79466464
Helicobacter infection 1184.25 20.07 1178 211710 68526 79462974
Rheumatoid factor positive 1182.31 20.07 1099 211789 58740 79472760
Hepatic enzyme increased 1140.10 20.07 1873 211015 180737 79350763
Acute kidney injury 1117.69 20.07 68 212820 519336 79012164
Folliculitis 1057.32 20.07 998 211890 54382 79477118
Irritable bowel syndrome 1024.33 20.07 1034 211854 61207 79470293
Muscle injury 1021.82 20.07 924 211964 47637 79483863
Drug interaction 1002.94 20.07 22 212866 415161 79116339
Pain 991.46 20.07 4102 208786 699700 78831800
Sleep disorder due to general medical condition, insomnia type 968.39 20.07 855 212033 42701 79488799
Toxicity to various agents 944.74 20.07 43 212845 421497 79110003
Blister 893.31 20.07 1332 211556 118144 79413356
Lower respiratory tract infection 865.44 20.07 1369 211519 127851 79403649
Hypotension 839.24 20.07 97 212791 440220 79091280
Rheumatoid arthritis 836.74 20.07 1769 211119 206701 79324799
Rash 829.75 20.07 3392 209496 574966 78956534
Infection 808.46 20.07 1907 210981 239805 79291695
Anaemia 784.22 20.07 125 212763 444890 79086610
Impaired healing 769.37 20.07 1055 211833 86600 79444900
Infusion related reaction 732.70 20.07 1782 211106 228455 79303045
Arthralgia 724.28 20.07 3230 209658 568573 78962927
Sinusitis 702.49 20.07 1587 211301 193914 79337586
Musculoskeletal stiffness 697.26 20.07 1481 211407 173527 79357973
Maternal exposure before pregnancy 695.55 20.07 303 212585 4070 79527430
Ill-defined disorder 670.88 20.07 853 212035 65022 79466478
Completed suicide 618.32 20.07 7 212881 245760 79285740
Peripheral swelling 615.40 20.07 1846 211042 267771 79263729
Thrombocytopenia 590.78 20.07 28 212860 265231 79266269
Febrile neutropenia 574.79 20.07 8 212880 230991 79300509
Death 572.71 20.07 408 212480 566106 78965394
Rheumatic fever 567.16 20.07 526 212362 27999 79503501
Product use issue 563.70 20.07 1524 211364 208298 79323202
Psoriatic arthropathy 563.29 20.07 856 212032 77143 79454357
Fall 529.44 20.07 324 212564 487305 79044195
Neutropenia 524.42 20.07 73 212815 287637 79243863
Gastrointestinal disorder 510.70 20.07 1055 211833 121150 79410350
Hip arthroplasty 452.29 20.07 517 212371 35239 79496261
Knee arthroplasty 443.35 20.07 562 212326 42686 79488814
Constipation 436.58 20.07 109 212779 282941 79248559
Nasopharyngitis 435.26 20.07 1578 211310 252303 79279197
Swollen joint count increased 429.37 20.07 409 212479 22518 79508982
Loss of personal independence in daily activities 427.84 20.07 885 212003 101695 79429805
Stomatitis 424.42 20.07 1096 211792 145661 79385839
C-reactive protein abnormal 419.41 20.07 579 212309 47788 79483712
Hyponatraemia 419.16 20.07 12 212876 177836 79353664
Renal failure 393.24 20.07 40 212848 200928 79330572
Mobility decreased 391.62 20.07 949 211939 121226 79410274
Cardiac arrest 390.18 20.07 16 212872 172080 79359420
Pregnancy 375.21 20.07 409 212479 26442 79505058
Disease progression 367.81 20.07 34 212854 184328 79347172
Pancytopenia 357.89 20.07 21 212867 165724 79365776
Maternal exposure during breast feeding 353.95 20.07 165 212723 2620 79528880
Dehydration 348.64 20.07 114 212774 248073 79283427
Seizure 343.73 20.07 48 212840 188786 79342714
Haemoglobin decreased 337.69 20.07 88 212800 222031 79309469
Adverse event 330.56 20.07 584 212304 59630 79471870
Respiratory failure 326.91 20.07 47 212841 180864 79350636
Renal impairment 325.98 20.07 25 212863 157758 79373742
Platelet count decreased 324.24 20.07 63 212825 194601 79336899
Drug hypersensitivity 323.84 20.07 1616 211272 297300 79234200
Sepsis 318.02 20.07 161 212727 269267 79262233
Somnolence 314.79 20.07 122 212766 238859 79292641
Fibromyalgia 313.95 20.07 593 212295 63747 79467753
Bradycardia 305.93 20.07 13 212875 135544 79395956
Oxygen saturation decreased 299.38 20.07 10 212878 129037 79402463
Gastrointestinal haemorrhage 295.27 20.07 27 212861 147692 79383808
Tachycardia 288.83 20.07 61 212827 177707 79353793
Hyperkalaemia 288.75 20.07 3 212885 114395 79417105
Foot deformity 280.90 20.07 334 212554 23740 79507760
Tremor 277.08 20.07 58 212830 170025 79361475
Night sweats 276.62 20.07 498 212390 51597 79479903
Cardiac failure congestive 271.74 20.07 31 212857 142371 79389129
Therapeutic product effect incomplete 269.71 20.07 912 211976 140733 79390767
Type 2 diabetes mellitus 265.80 20.07 516 212372 56606 79474894
Cardio-respiratory arrest 264.58 20.07 5 212883 108505 79422995
Blood cholesterol increased 261.45 20.07 644 212244 83076 79448424
Pulmonary embolism 260.87 20.07 68 212820 171586 79359914
Intentional overdose 257.88 20.07 5 212883 105955 79425545
Overdose 256.20 20.07 86 212802 184120 79347380
Coma 248.03 20.07 4 212884 100645 79430855
Syncope 247.45 20.07 85 212803 179364 79352136
Bone erosion 246.12 20.07 270 212618 17577 79513923
Multiple organ dysfunction syndrome 245.71 20.07 20 212868 120226 79411274
Hypokalaemia 243.26 20.07 45 212843 143995 79387505
Cough 239.40 20.07 381 212507 366408 79165092
Rhabdomyolysis 239.18 20.07 8 212880 103123 79428377
Cardiac failure 237.86 20.07 60 212828 154782 79376718
Depressed level of consciousness 237.51 20.07 4 212884 96648 79434852
Dyspnoea 235.90 20.07 1335 211553 855690 78675810
Neutrophil count decreased 234.70 20.07 3 212885 93956 79437544
Tenosynovitis 229.72 20.07 244 212644 15310 79516190
Rheumatoid nodule 228.74 20.07 257 212631 17181 79514319
Hypoglycaemia 228.38 20.07 10 212878 101584 79429916
White blood cell count decreased 227.41 20.07 109 212779 188179 79343321
Enthesopathy 224.81 20.07 211 212677 11397 79520103
Electrocardiogram QT prolonged 217.05 20.07 5 212883 90381 79441119
Hypoxia 214.24 20.07 16 212872 103227 79428273
Grip strength decreased 211.23 20.07 276 212612 21593 79509907
Contusion 205.96 20.07 865 212023 147911 79383589
Agitation 205.36 20.07 16 212872 99699 79431801
Cerebrovascular accident 199.95 20.07 82 212806 155210 79376290
Dysphagia 196.13 20.07 43 212845 122093 79409407
Inflammation 188.50 20.07 615 212273 93138 79438362
Hallucination 187.71 20.07 10 212878 85735 79445765
Red blood cell sedimentation rate increased 187.47 20.07 393 212495 45549 79485951
Liver injury 186.89 20.07 445 212443 56169 79475331
Adverse drug reaction 184.73 20.07 489 212399 65903 79465597
Neuropathy peripheral 182.92 20.07 74 212814 141231 79390269
Blood creatinine increased 180.84 20.07 94 212794 154963 79376537
Metabolic acidosis 179.50 20.07 10 212878 82519 79448981
Pulmonary oedema 176.69 20.07 16 212872 88238 79443262
Blood pressure decreased 172.45 20.07 29 212859 99437 79432063
Psoriasis 172.36 20.07 579 212309 89008 79442492
Urticaria 171.94 20.07 960 211928 184241 79347259
Ear pain 170.38 20.07 311 212577 32558 79498942
Epistaxis 169.73 20.07 44 212844 111471 79420029
Deep vein thrombosis 168.88 20.07 56 212832 120863 79410637
Balance disorder 168.81 20.07 30 212858 98827 79432673
Pruritus 167.92 20.07 1700 211188 392948 79138552
Breast feeding 166.50 20.07 65 212823 647 79530853
C-reactive protein increased 165.36 20.07 733 212155 128294 79403206
Suicide attempt 163.46 20.07 16 212872 82916 79448584
Joint stiffness 162.79 20.07 346 212542 40484 79491016
Fatigue 159.48 20.07 3417 209471 926310 78605190
Atrial fibrillation 159.13 20.07 176 212712 197710 79333790
Ascites 158.81 20.07 11 212877 75551 79455949
Drug tolerance decreased 157.93 20.07 184 212704 12794 79518706
Hyperglycaemia 157.82 20.07 7 212881 70328 79461172
Glaucoma 155.63 20.07 226 212662 19535 79511965
Hyperhidrosis 154.04 20.07 108 212780 151384 79380116
Muscle spasticity 153.93 20.07 235 212653 21240 79510260
Product availability issue 153.90 20.07 108 212780 3839 79527661
Chronic kidney disease 153.85 20.07 5 212883 66149 79465351
Myalgia 153.84 20.07 161 212727 185480 79346020
Pleural effusion 152.46 20.07 100 212788 145162 79386338
Mental status changes 152.46 20.07 6 212882 66953 79464547
Leukopenia 152.46 20.07 60 212828 116453 79415047
Chest discomfort 150.43 20.07 91 212797 137953 79393547
Septic shock 149.91 20.07 70 212818 122731 79408769
Lower limb fracture 149.70 20.07 242 212646 22973 79508527
Lethargy 149.43 20.07 20 212868 81272 79450228
Dizziness 148.79 20.07 812 212076 525629 79005871
Pustular psoriasis 147.88 20.07 114 212774 4692 79526808
Red blood cell sedimentation rate 147.66 20.07 121 212767 5444 79526056
Blood creatine phosphokinase increased 146.91 20.07 7 212881 66083 79465417
Dyspnoea exertional 145.29 20.07 28 212860 87045 79444455
Therapy interrupted 144.40 20.07 282 212606 31059 79500441
Pneumonia aspiration 142.95 20.07 9 212879 66958 79464542
Myocardial infarction 142.36 20.07 169 212719 183960 79347540
Anxiety 142.24 20.07 280 212608 248232 79283268
Oedema peripheral 142.05 20.07 287 212601 252001 79279499
Colitis microscopic 141.74 20.07 159 212729 10609 79520891
Heart rate decreased 140.08 20.07 13 212875 70303 79461197
Tongue disorder 139.06 20.07 179 212709 13796 79517704
COVID-19 immunisation 138.90 20.07 70 212818 1329 79530171
Blood parathyroid hormone decreased 137.70 20.07 155 212733 10381 79521119
Hepatic failure 137.64 20.07 6 212882 61206 79470294
Injection site reaction 136.95 20.07 388 212500 54397 79477103
Acute myocardial infarction 136.82 20.07 21 212867 77015 79454485
Blood pressure increased 136.38 20.07 221 212667 211139 79320361
Alanine aminotransferase abnormal 136.11 20.07 142 212746 8725 79522775
Flushing 135.92 20.07 34 212854 88234 79443266
Joint range of motion decreased 134.95 20.07 284 212604 32998 79498502
Cognitive disorder 133.93 20.07 15 212873 69911 79461589
Asthenia 133.43 20.07 810 212078 510879 79020621
Facet joint syndrome 132.15 20.07 157 212731 11145 79520355
Unresponsive to stimuli 130.51 20.07 4 212884 55784 79475716
Blood bilirubin increased 129.95 20.07 13 212875 66219 79465281
Lip dry 129.76 20.07 182 212706 15236 79516264
Haematuria 128.78 20.07 16 212872 68820 79462680
Deep vein thrombosis postoperative 128.44 20.07 151 212737 10601 79520899
Dysarthria 128.27 20.07 15 212873 67607 79463893
Disorientation 126.69 20.07 11 212877 62765 79468735
Weight decreased 126.17 20.07 504 212384 354694 79176806
Panniculitis 125.53 20.07 160 212728 12211 79519289
Granuloma skin 125.12 20.07 138 212750 9036 79522464
Haemoptysis 124.25 20.07 6 212882 55993 79475507
Plasma cell myeloma 123.94 20.07 4 212884 53255 79478245
Blood glucose increased 123.59 20.07 77 212811 114898 79416602
Neoplasm progression 123.53 20.07 3 212885 51679 79479821
Heart rate increased 122.81 20.07 86 212802 120638 79410862
Orthostatic hypotension 121.54 20.07 7 212881 56157 79475343
Arthritis 120.52 20.07 616 212272 114264 79417236
Chills 119.71 20.07 151 212737 160083 79371417
Ankylosing spondylitis 119.36 20.07 155 212733 12050 79519450
Adjustment disorder with depressed mood 119.31 20.07 134 212754 8952 79522548
Onychomycosis 119.17 20.07 128 212760 8133 79523367
Exposure during pregnancy 118.74 20.07 560 212328 100572 79430928
Acute respiratory failure 116.00 20.07 12 212876 59529 79471971
Nail disorder 115.10 20.07 150 212738 11702 79519798
Gastric disorder 114.74 20.07 286 212602 37147 79494353
Suicidal ideation 114.49 20.07 31 212857 76309 79455191
Melaena 114.28 20.07 14 212874 60876 79470624
Respiratory distress 113.03 20.07 12 212876 58327 79473173
Injury 113.01 20.07 458 212430 77038 79454462
Hepatic function abnormal 112.87 20.07 28 212860 73079 79458421
Haemorrhage 112.66 20.07 51 212837 91067 79440433
Hypomagnesaemia 111.08 20.07 3 212885 46908 79484592
Vision blurred 110.97 20.07 73 212815 105825 79425675
Haematocrit decreased 110.53 20.07 16 212872 61296 79470204
Pulmonary hypertension 110.52 20.07 4 212884 48076 79483424
Injection site discolouration 109.88 20.07 118 212770 7496 79524004
Prescribed overdose 109.42 20.07 283 212605 37600 79493900
Coronary artery disease 109.35 20.07 21 212867 65453 79466047
Mucosal inflammation 109.09 20.07 33 212855 75547 79455953
Cerebral haemorrhage 108.88 20.07 13 212875 57660 79473840
Gastrooesophageal reflux disease 107.71 20.07 73 212815 104173 79427327
Anti-cyclic citrullinated peptide antibody 106.90 20.07 103 212785 5749 79525751
Urinary retention 106.33 20.07 13 212875 56617 79474883
Agranulocytosis 106.17 20.07 3 212885 45027 79486473
Jaundice 105.90 20.07 10 212878 53339 79478161
Aggression 105.41 20.07 8 212880 50950 79480550
General physical health deterioration 105.32 20.07 1161 211727 274077 79257423
Onychomadesis 104.81 20.07 97 212791 5145 79526355
Angioedema 104.79 20.07 36 212852 75999 79455501
Hypercholesterolaemia 104.21 20.07 206 212682 22889 79508611
Blood urea increased 102.82 20.07 7 212881 48783 79482717
Weight increased 102.47 20.07 1162 211726 276224 79255276
Live birth 101.79 20.07 181 212707 18563 79512937
Osteonecrosis of jaw 101.48 20.07 3 212885 43223 79488277
Condition aggravated 100.91 20.07 1888 211000 499236 79032264
Cholestasis 100.24 20.07 11 212877 52098 79479402
Peripheral venous disease 100.08 20.07 164 212724 15745 79515755
Intentional product use issue 99.81 20.07 722 212166 151390 79380110
Bursitis 99.67 20.07 264 212624 35580 79495920
Productive cough 99.38 20.07 56 212832 88275 79443225
Chest pain 99.29 20.07 402 212486 281902 79249598
Nausea 99.12 20.07 1881 211007 955315 78576185
Shock 98.81 20.07 4 212884 43544 79487956
Vomiting 98.71 20.07 1221 211667 664607 78866893
Maternal exposure timing unspecified 98.44 20.07 98 212790 5694 79525806
Osteoarthritis 97.81 20.07 477 212411 86832 79444668
Tendonitis 97.37 20.07 204 212684 23626 79507874
Drug tolerance 97.32 20.07 118 212770 8557 79522943
Hypophagia 97.11 20.07 6 212882 45361 79486139
Blood alkaline phosphatase increased 97.09 20.07 25 212863 63639 79467861
Exostosis 97.02 20.07 167 212721 16691 79514809
Joint dislocation 96.43 20.07 167 212721 16772 79514728
Altered state of consciousness 96.26 20.07 5 212883 43817 79487683
Sciatica 95.76 20.07 248 212640 32974 79498526
Off label use 95.09 20.07 3127 209761 904088 78627412
Coeliac disease 92.57 20.07 132 212756 11219 79520281
Body temperature increased 92.51 20.07 295 212593 44125 79487375
Aphasia 92.13 20.07 9 212879 46723 79484777
Systemic lupus erythematosus rash 92.00 20.07 59 212829 1801 79529699
Respiratory disorder 91.69 20.07 296 212592 44560 79486940
Liver function test abnormal 91.53 20.07 29 212859 64446 79467054
Loss of consciousness 91.15 20.07 195 212693 167748 79363752
Haematemesis 91.11 20.07 15 212873 52249 79479251
Feeling abnormal 90.50 20.07 180 212708 159019 79372481
Pallor 90.39 20.07 13 212875 50049 79481451
Blood iron abnormal 89.80 20.07 52 212836 1315 79530185
Dislocation of vertebra 89.73 20.07 108 212780 7772 79523728
Autoimmune disorder 89.68 20.07 160 212728 16452 79515048
Retinitis 89.55 20.07 92 212796 5551 79525949
Ventricular tachycardia 88.42 20.07 6 212882 41929 79489571
Pulmonary fibrosis 88.28 20.07 289 212599 43823 79487677
Blood lactate dehydrogenase increased 87.54 20.07 4 212884 39166 79492334
Restlessness 86.49 20.07 11 212877 46481 79485019
Presyncope 86.19 20.07 6 212882 41048 79490452
Skin necrosis 86.07 20.07 165 212723 17922 79513578
Seronegative arthritis 84.61 20.07 82 212806 4610 79526890
Arrhythmia 84.45 20.07 29 212859 61243 79470257
Upper gastrointestinal haemorrhage 84.18 20.07 7 212881 41373 79490127
Pericardial effusion 83.50 20.07 12 212876 46225 79485275
Emotional distress 83.46 20.07 6 212882 39963 79491537
Pneumonia 82.98 20.07 1252 211636 658994 78872506
Red blood cell sedimentation rate abnormal 82.81 20.07 177 212711 20786 79510714
Generalised tonic-clonic seizure 82.64 20.07 10 212878 43900 79487600
Full blood count abnormal 81.92 20.07 7 212881 40467 79491033
Psychotic disorder 81.55 20.07 8 212880 41394 79490106
Caesarean section 81.27 20.07 131 212757 12404 79519096
Haematochezia 80.79 20.07 69 212819 87576 79443924
Lupus-like syndrome 80.70 20.07 138 212750 13719 79517781
Dysgeusia 80.66 20.07 26 212862 57151 79474349
Arthrodesis 80.47 20.07 60 212828 2347 79529153
Disturbance in attention 79.31 20.07 19 212869 50782 79480718
Depression 79.20 20.07 304 212584 216486 79315014
Leukocytosis 79.12 20.07 11 212877 43444 79488056
Wrong technique in product usage process 78.66 20.07 50 212838 73825 79457675
Palpitations 78.28 20.07 136 212752 126474 79405026
Blood potassium decreased 77.49 20.07 15 212873 46497 79485003
Abnormal behaviour 77.41 20.07 5 212883 36416 79495084
Deformity 77.31 20.07 111 212777 9494 79522006
Pneumonitis 76.91 20.07 33 212855 60827 79470673
Speech disorder 76.38 20.07 25 212863 54420 79477080
Transient ischaemic attack 76.06 20.07 23 212865 52672 79478828
Stevens-Johnson syndrome 76.02 20.07 8 212880 39158 79492342
Sinus tachycardia 75.76 20.07 6 212882 36902 79494598
Angina pectoris 75.72 20.07 22 212866 51710 79479790
Blood sodium decreased 75.63 20.07 3 212885 33252 79498248
Urinary incontinence 75.33 20.07 10 212878 40899 79490601
Gamma-glutamyltransferase increased 75.15 20.07 26 212862 54654 79476846
Therapy non-responder 74.91 20.07 462 212426 91843 79439657
Eosinophilia 74.76 20.07 15 212873 45330 79486170
Hepatocellular injury 73.91 20.07 18 212870 47575 79483925
Proteinuria 73.69 20.07 3 212885 32499 79499001
Coagulopathy 73.50 20.07 6 212882 36000 79495500
Intentional self-injury 73.48 20.07 3 212885 32416 79499084
Disseminated intravascular coagulation 73.09 20.07 6 212882 35836 79495664
Pancreatitis acute 72.78 20.07 21 212867 49583 79481917
Basal cell carcinoma 71.35 20.07 241 212647 37134 79494366
Musculoskeletal pain 71.30 20.07 493 212395 101861 79429639
Obstructive airways disorder 71.00 20.07 3 212885 31456 79500044
Bone pain 70.80 20.07 30 212858 55712 79475788
Cytomegalovirus infection 70.53 20.07 14 212874 42630 79488870
Tinnitus 70.36 20.07 16 212872 44317 79487183
Fine motor skill dysfunction 70.33 20.07 79 212809 5278 79526222
Diarrhoea 70.12 20.07 1803 211085 878686 78652814
Rectal haemorrhage 69.19 20.07 61 212827 76239 79455261
Irritability 69.12 20.07 13 212875 41131 79490369
Skin reaction 68.52 20.07 140 212748 15928 79515572
Gait inability 68.22 20.07 325 212563 58592 79472908
Circulatory collapse 67.50 20.07 10 212878 37658 79493842
Ejection fraction decreased 67.27 20.07 7 212881 34570 79496930
Ulcer 66.98 20.07 204 212684 29768 79501732
Haematoma 66.44 20.07 28 212860 52167 79479333
Drug dependence 66.15 20.07 14 212874 40755 79490745
Lymphopenia 65.53 20.07 4 212884 30553 79500947
Rheumatoid factor negative 65.03 20.07 40 212848 1133 79530367
Subdural haematoma 64.83 20.07 5 212883 31429 79500071
Musculoskeletal disorder 64.81 20.07 163 212725 21285 79510215
Fear of injection 64.04 20.07 89 212799 7385 79524115
Dysuria 63.79 20.07 28 212860 50923 79480577
Acute myeloid leukaemia 63.45 20.07 5 212883 30880 79500620
Depressed mood 63.34 20.07 25 212863 48455 79483045
Blood calcium decreased 63.06 20.07 6 212882 31813 79499687
Herpes zoster 62.86 20.07 445 212443 92638 79438862
Chronic obstructive pulmonary disease 62.22 20.07 82 212806 85337 79446163
Product dose omission issue 62.19 20.07 967 211921 246570 79284930
Blood pressure fluctuation 61.71 20.07 53 212835 67092 79464408
Diabetic ketoacidosis 61.28 20.07 9 212879 34113 79497387
Red blood cell count decreased 61.12 20.07 39 212849 57474 79474026
Thrombosis 60.99 20.07 81 212807 84019 79447481
Cerebral infarction 60.60 20.07 23 212865 45653 79485847
Bacteraemia 60.49 20.07 8 212880 32816 79498684
Mitral valve incompetence 60.48 20.07 4 212884 28561 79502939
Hemiparesis 60.34 20.07 9 212879 33724 79497776
Cardiac disorder 60.32 20.07 52 212836 65705 79465795
Tubulointerstitial nephritis 60.28 20.07 14 212874 38221 79493279
Latent tuberculosis 59.34 20.07 58 212830 3295 79528205
Myoclonus 58.19 20.07 4 212884 27656 79503844
Product administration error 58.12 20.07 8 212880 31838 79499662
Foot operation 57.93 20.07 74 212814 5659 79525841
Acute respiratory distress syndrome 57.12 20.07 23 212865 44044 79487456
Rash maculo-papular 56.94 20.07 40 212848 56038 79475462
Pain in jaw 56.78 20.07 26 212862 46125 79485375
Nerve injury 56.63 20.07 95 212793 9297 79522203
Head injury 56.36 20.07 15 212873 37354 79494146
Tachypnoea 56.34 20.07 9 212879 32054 79499446
C-reactive protein 56.30 20.07 68 212820 4911 79526589
Breast cancer stage III 56.09 20.07 97 212791 9729 79521771
Abortion spontaneous 56.09 20.07 190 212698 29317 79502183
Twin pregnancy 56.00 20.07 33 212855 863 79530637
Adverse reaction 55.88 20.07 94 212794 9220 79522280
Premature delivery 55.54 20.07 163 212725 23304 79508196
Cyanosis 54.91 20.07 3 212885 25179 79506321
Status epilepticus 54.55 20.07 3 212885 25038 79506462
Myelodysplastic syndrome 54.40 20.07 8 212880 30293 79501207
Decreased appetite 54.01 20.07 619 212269 341799 79189701
Abdominal pain 53.65 20.07 725 212163 388844 79142656
Withdrawal syndrome 53.39 20.07 5 212883 26849 79504651
Full blood count decreased 53.30 20.07 5 212883 26814 79504686
White blood cell count increased 52.98 20.07 73 212815 74560 79456940
X-ray abnormal 52.49 20.07 71 212817 5742 79525758
Hypothyroidism 52.37 20.07 38 212850 52354 79479146
Sleep disorder 52.37 20.07 400 212488 85277 79446223
Transaminases abnormal 51.92 20.07 31 212857 831 79530669
Fluid retention 51.89 20.07 66 212822 69743 79461757
Vertigo 51.67 20.07 65 212823 69017 79462483
Cholelithiasis 51.61 20.07 39 212849 52625 79478875
Axial spondyloarthritis 51.47 20.07 27 212861 559 79530941
Tuberculin test positive 51.27 20.07 54 212834 3354 79528146
Bedridden 51.22 20.07 105 212783 11974 79519526
Ischaemic stroke 50.53 20.07 13 212875 33118 79498382
Accidental exposure to product 50.32 20.07 11 212877 31311 79500189
Pneumothorax 49.65 20.07 8 212880 28315 79503185
Tuberculosis 49.63 20.07 119 212769 15079 79516421
Acute hepatic failure 49.56 20.07 10 212878 30103 79501397
Disability 49.54 20.07 128 212760 16992 79514508
Heart rate irregular 49.51 20.07 13 212875 32666 79498834
Diplopia 49.41 20.07 14 212874 33452 79498048
Electrolyte imbalance 49.30 20.07 11 212877 30870 79500630
Feeling hot 49.22 20.07 52 212836 59682 79471818
Cytology abnormal 48.67 20.07 22 212866 324 79531176
Glomerular filtration rate decreased 48.60 20.07 3 212885 22699 79508801
Gastric ulcer 48.57 20.07 15 212873 33890 79497610
Feeling cold 48.42 20.07 9 212879 28720 79502780
Therapeutic response decreased 48.33 20.07 325 212563 66528 79464972
Hepatic cirrhosis 48.27 20.07 203 212685 34703 79496797
Intentional dose omission 47.69 20.07 85 212803 8732 79522768
Bronchopulmonary aspergillosis 47.56 20.07 3 212885 22291 79509209
Throat irritation 47.44 20.07 25 212863 40921 79490579
Physical disability 47.39 20.07 51 212837 3247 79528253
Dry skin 46.79 20.07 68 212820 67927 79463573
Ankle arthroplasty 46.54 20.07 36 212852 1489 79530011
Hypocalcaemia 46.37 20.07 39 212849 49885 79481615
Obesity 46.05 20.07 201 212687 34924 79496576
Visual acuity reduced 46.04 20.07 11 212877 29458 79502042
Palmoplantar pustulosis 45.97 20.07 25 212863 558 79530942
Blindness 45.53 20.07 10 212878 28373 79503127
Inability to afford medication 45.44 20.07 46 212842 2727 79528773
Myocardial ischaemia 45.21 20.07 7 212881 25512 79505988
Transfusion 45.12 20.07 3 212885 21327 79510173
Transaminases increased 44.97 20.07 43 212845 51700 79479800
Rhinorrhoea 44.97 20.07 84 212804 75990 79455510
Hepatic cytolysis 44.72 20.07 9 212879 27142 79504358
Extremity contracture 44.58 20.07 37 212851 1695 79529805
Polyneuropathy 44.24 20.07 6 212882 24145 79507355
Bunion operation 44.15 20.07 29 212859 923 79530577
Osteoporosis 43.99 20.07 271 212617 53841 79477659
Nasal congestion 43.96 20.07 86 212802 76466 79455034
Neutrophil count increased 43.95 20.07 12 212876 29384 79502116
Wound infection 43.43 20.07 152 212736 23839 79507661
Myocarditis 43.33 20.07 4 212884 21729 79509771
Myopathy 43.18 20.07 3 212885 20560 79510940
Dysphonia 43.07 20.07 53 212835 56819 79474681
Respiratory rate increased 43.00 20.07 4 212884 21596 79509904
Flatulence 42.69 20.07 31 212857 42693 79488807
Sudden death 42.67 20.07 5 212883 22506 79508994
Metastases to bone 42.60 20.07 7 212881 24420 79507080
Cardiomyopathy 42.55 20.07 12 212876 28762 79502738
Ileus 42.52 20.07 9 212879 26202 79505298
Swollen tongue 42.39 20.07 31 212857 42539 79488961
Supraventricular tachycardia 42.18 20.07 4 212884 21266 79510234
Blood pressure diastolic decreased 42.16 20.07 14 212874 30202 79501298
Hepatic encephalopathy 41.98 20.07 7 212881 24159 79507341
Myelosuppression 41.90 20.07 28 212860 40268 79491232
Lip swelling 41.78 20.07 29 212859 40882 79490618
Nightmare 41.71 20.07 9 212879 25852 79505648
Nephrolithiasis 41.52 20.07 264 212624 53027 79478473
Femur fracture 41.36 20.07 26 212862 38626 79492874
Sleep apnoea syndrome 41.20 20.07 23 212865 36455 79495045
Acidosis 41.16 20.07 3 212885 19759 79511741
Tricuspid valve incompetence 41.04 20.07 3 212885 19709 79511791
Cardiomegaly 40.85 20.07 10 212878 26342 79505158
Colitis 40.69 20.07 84 212804 73223 79458277
Foot fracture 40.43 20.07 140 212748 21841 79509659
Nodule 40.18 20.07 144 212744 22850 79508650
Delusion 40.08 20.07 4 212884 20419 79511081
Joint destruction 39.89 20.07 63 212825 5862 79525638
Abdominal distension 39.77 20.07 174 212714 119476 79412024
Product substitution issue 39.67 20.07 4 212884 20252 79511248
Aspergillus infection 39.65 20.07 3 212885 19158 79512342
Hyperthyroidism 39.55 20.07 6 212882 22203 79509297
Bronchospasm 39.39 20.07 9 212879 24850 79506650
Ear infection 39.18 20.07 189 212699 34243 79497257
COVID-19 pneumonia 39.16 20.07 14 212874 28835 79502665
Cardiac failure acute 39.07 20.07 3 212885 18926 79512574
Skin exfoliation 39.00 20.07 54 212834 55046 79476454
Lung infiltration 39 20.07 7 212881 22905 79508595
Pseudomonas infection 38.75 20.07 5 212883 20898 79510602
Hypoacusis 38.65 20.07 16 212872 30134 79501366
Hot flush 38.63 20.07 54 212834 54823 79476677
Rheumatoid lung 38.56 20.07 52 212836 4193 79527307
Lupus vulgaris 38.33 20.07 46 212842 3300 79528200
Body temperature decreased 38.18 20.07 19 212869 32126 79499374
Haemorrhoids 38.09 20.07 15 212873 29113 79502387
Epilepsy 37.85 20.07 32 212856 40828 79490672
Hypoalbuminaemia 37.37 20.07 6 212882 21291 79510209
Alanine aminotransferase increased 37.36 20.07 267 212621 162303 79369197
Arteriosclerosis 37.31 20.07 3 212885 18224 79513276
Muscle twitching 37.23 20.07 10 212878 24754 79506746
Clostridium difficile colitis 36.98 20.07 20 212868 32263 79499237
Device related infection 36.79 20.07 23 212865 34271 79497229
Hypermobility syndrome 36.62 20.07 21 212867 521 79530979
Hyperlipidaemia 36.56 20.07 12 212876 26081 79505419
Hallucination, auditory 35.93 20.07 6 212882 20687 79510813
Peritonitis 35.74 20.07 15 212873 28021 79503479
Urinary tract infection 35.58 20.07 517 212371 273995 79257505
Device malfunction 35.55 20.07 7 212881 21441 79510059
Skin ulcer 35.46 20.07 257 212631 53893 79477607
Crying 35.22 20.07 9 212879 23034 79508466
Dementia 35.16 20.07 11 212877 24648 79506852
Polyarthritis 35.07 20.07 91 212797 12111 79519389
Coordination abnormal 35.02 20.07 3 212885 17309 79514191
Acute generalised exanthematous pustulosis 34.87 20.07 3 212885 17251 79514249
Diverticulitis 34.82 20.07 226 212662 45710 79485790
COVID-19 34.77 20.07 262 212626 157412 79374088
Metastases to liver 34.75 20.07 16 212872 28298 79503202
Blood triglycerides increased 34.60 20.07 7 212881 21033 79510467
Insurance issue 34.58 20.07 58 212830 5675 79525825
Muscular weakness 34.54 20.07 269 212619 160460 79371040
Abdominal pain lower 34.53 20.07 21 212867 31761 79499739
Eosinophil count increased 34.50 20.07 3 212885 17102 79514398
Pancreatitis 34.44 20.07 83 212805 68492 79463008
Product label confusion 34.29 20.07 31 212857 1595 79529905
Rales 34.29 20.07 6 212882 19995 79511505
Aspartate aminotransferase increased 34.19 20.07 223 212665 138418 79393082
Atrial flutter 33.93 20.07 8 212880 21617 79509883
Hip fracture 33.88 20.07 20 212868 30741 79500759
Arteriosclerosis coronary artery 33.66 20.07 4 212884 17812 79513688
Blood glucose decreased 33.50 20.07 14 212874 26220 79505280
Petechiae 33.49 20.07 7 212881 20558 79510942
Laryngitis 32.91 20.07 106 212782 15933 79515567
Hunger 32.86 20.07 55 212833 5373 79526127
Mania 32.37 20.07 5 212883 18255 79513245
Drug resistance 32.32 20.07 39 212849 42174 79489326
Device issue 32.23 20.07 16 212872 27092 79504408
Mental disorder 32.21 20.07 22 212866 31280 79500220
Poor venous access 32.10 20.07 5 212883 18144 79513356
Mental impairment 32.01 20.07 6 212882 19030 79512470
Faeces discoloured 31.99 20.07 19 212869 29108 79502392
Splenomegaly 31.93 20.07 8 212880 20746 79510754
Epicondylitis 31.86 20.07 34 212854 2144 79529356
Pyrexia 31.70 20.07 1485 211403 677224 78854276
Disease susceptibility 31.60 20.07 16 212872 307 79531193
Ventricular extrasystoles 31.49 20.07 7 212881 19697 79511803
Subarachnoid haemorrhage 31.33 20.07 13 212875 24452 79507048
Paraesthesia oral 31.28 20.07 8 212880 20463 79511037
Immune thrombocytopenia 31.28 20.07 5 212883 17800 79513700
Oesophagitis 30.96 20.07 13 212875 24276 79507224
SARS-CoV-2 test negative 30.62 20.07 27 212861 1344 79530156
Allergy to chemicals 30.18 20.07 36 212852 2566 79528934
Intentional product misuse 30.07 20.07 141 212747 95024 79436476
Pemphigoid 30.05 20.07 3 212885 15312 79516188
Toxic skin eruption 29.95 20.07 11 212877 22282 79509218
Rash erythematous 29.74 20.07 69 212819 57700 79473800
Walking aid user 29.49 20.07 76 212812 10072 79521428
Chromaturia 29.42 20.07 16 212872 25730 79505770
Blood albumin decreased 29.29 20.07 14 212874 24229 79507271
Uveitis 29.07 20.07 105 212783 16725 79514775
Haemophagocytic lymphohistiocytosis 28.96 20.07 11 212877 21826 79509674
Joint lock 28.53 20.07 39 212849 3186 79528314
Decubitus ulcer 28.49 20.07 4 212884 15683 79515817
Enterococcal infection 28.42 20.07 4 212884 15656 79515844
Impaired work ability 28.42 20.07 116 212772 19565 79511935
Rib fracture 28.29 20.07 20 212868 27927 79503573
Diabetic eye disease 28.10 20.07 12 212876 153 79531347
Hypokinesia 28.09 20.07 8 212880 19052 79512448
Rash pruritic 27.72 20.07 303 212585 71326 79460174
Spinal fusion surgery 27.69 20.07 50 212838 5188 79526312
Rash macular 27.55 20.07 22 212866 28877 79502623
Gastritis 27.48 20.07 54 212834 47939 79483561
Joint effusion 27.48 20.07 108 212780 17906 79513594
Hiatus hernia 27.35 20.07 14 212874 23298 79508202
Cold sweat 27.28 20.07 8 212880 18691 79512809
Neck mass 27.16 20.07 45 212843 4359 79527141
Anal abscess 27.12 20.07 70 212818 9285 79522215
Paranoia 27.12 20.07 9 212879 19423 79512077
Oral pain 26.97 20.07 27 212861 31771 79499729
Atrioventricular block 26.91 20.07 3 212885 14038 79517462
Glycosylated haemoglobin increased 26.74 20.07 9 212879 19251 79512249
Muscle spasms 26.68 20.07 318 212570 174412 79357088
Toothache 26.58 20.07 10 212878 19960 79511540
Cardiac murmur 26.58 20.07 5 212883 15819 79515681
Hepatitis cholestatic 26.45 20.07 3 212885 13849 79517651
Immune reconstitution inflammatory syndrome 26.42 20.07 3 212885 13838 79517662
Hypoaesthesia 26.35 20.07 646 212242 178706 79352794
Skin discolouration 26.35 20.07 43 212845 40991 79490509
Panic attack 26.31 20.07 16 212872 24200 79507300
Renal cyst 26.19 20.07 4 212884 14728 79516772
Abortion 26.10 20.07 25 212863 1385 79530115
Prescribed underdose 26.03 20.07 151 212737 29363 79502137
Gout 26.00 20.07 17 212871 24732 79506768
Skin lesion 25.80 20.07 45 212843 41799 79489701
Kidney infection 25.63 20.07 121 212767 21730 79509770
Disseminated large cell lymphoma 25.45 20.07 9 212879 66 79531434
Cutaneous lymphoma 25.41 20.07 13 212875 255 79531245
Surgery 25.32 20.07 162 212726 32604 79498896
Joint ankylosis 25.02 20.07 30 212858 2150 79529350
Activated partial thromboplastin time prolonged 24.98 20.07 4 212884 14224 79517276
Breath sounds abnormal 24.90 20.07 6 212882 15978 79515522
Infusion site pain 24.86 20.07 4 212884 14172 79517328
Peripheral sensory neuropathy 24.44 20.07 3 212885 13030 79518470
Nervousness 24.41 20.07 32 212856 33383 79498117
Therapy partial responder 24.38 20.07 8 212880 17389 79514111
Anal incontinence 24.35 20.07 9 212879 18159 79513341
Treatment noncompliance 24.14 20.07 66 212822 52202 79479298
Limb injury 24.00 20.07 26 212862 29502 79501998
Duodenal ulcer 23.88 20.07 7 212881 16362 79515138
Anger 23.86 20.07 8 212880 17154 79514346
Respiratory tract congestion 23.77 20.07 111 212777 19843 79511657
Mood altered 23.65 20.07 9 212879 17838 79513662
Large intestine perforation 23.64 20.07 5 212883 14562 79516938
Blood test abnormal 23.35 20.07 9 212879 17701 79513799
Perirectal abscess 23.28 20.07 28 212860 2013 79529487
Myositis 23.27 20.07 11 212877 19157 79512343
Second primary malignancy 23.13 20.07 5 212883 14345 79517155
Atrioventricular block first degree 23.12 20.07 3 212885 12488 79519012
Coronary artery stenosis 23.11 20.07 3 212885 12481 79519019
Device difficult to use 22.98 20.07 4 212884 13381 79518119
Pelvic pain 22.97 20.07 4 212884 13377 79518123
Pulmonary tuberculosis 22.96 20.07 59 212829 7806 79523694
Electrocardiogram abnormal 22.92 20.07 8 212880 16729 79514771
Blood uric acid increased 22.92 20.07 4 212884 13356 79518144
Malnutrition 22.91 20.07 16 212872 22486 79509014
Product complaint 22.89 20.07 4 212884 13345 79518155
Sensory disturbance 22.83 20.07 6 212882 15071 79516429
Hepatomegaly 22.65 20.07 11 212877 18863 79512637
Face oedema 22.62 20.07 25 212863 28111 79503389
Tooth infection 22.61 20.07 105 212783 18727 79512773
Asthma 22.54 20.07 241 212647 134854 79396646
Purpura 22.51 20.07 12 212876 19515 79511985
Blood pressure systolic increased 22.51 20.07 97 212791 66889 79464611
Gait disturbance 22.48 20.07 404 212484 207102 79324398
Multiple sclerosis 22.48 20.07 16 212872 22266 79509234
Abdominal pain upper 22.36 20.07 768 212120 223051 79308449
Injection site pallor 22.35 20.07 8 212880 61 79531439
Lipase increased 22.33 20.07 8 212880 16458 79515042
Throat tightness 22.21 20.07 25 212863 27882 79503618
Hypertensive crisis 22.18 20.07 14 212874 20756 79510744
Choking 22.18 20.07 3 212885 12098 79519402
Injection site urticaria 22.14 20.07 80 212808 12746 79518754
Injection site bruising 22.09 20.07 186 212702 40816 79490684
Sensory loss 22.04 20.07 4 212884 12987 79518513
Poor quality sleep 22.04 20.07 17 212871 22705 79508795
Apathy 22.01 20.07 4 212884 12973 79518527
Renal disorder 21.91 20.07 50 212838 42055 79489445
Blood pressure diastolic abnormal 21.84 20.07 12 212876 19190 79512310
Hepatitis C 21.75 20.07 3 212885 11922 79519578
Liver function test increased 21.73 20.07 181 212707 39592 79491908
Post procedural complication 21.66 20.07 19 212869 23810 79507690
Lacrimation increased 21.57 20.07 17 212871 22460 79509040
Limb discomfort 21.56 20.07 156 212732 32694 79498806
Cholangitis 21.54 20.07 4 212884 12772 79518728
Coronary artery occlusion 21.53 20.07 7 212881 15308 79516192
Middle insomnia 21.47 20.07 8 212880 16061 79515439
Hyperuricaemia 21.45 20.07 3 212885 11796 79519704
Sputum discoloured 21.43 20.07 16 212872 21727 79509773
Neuralgia 21.42 20.07 35 212853 33349 79498151
Congestive cardiomyopathy 21.40 20.07 3 212885 11777 79519723
Quarantine 21.28 20.07 7 212881 40 79531460
Metastases to lung 21.17 20.07 11 212877 18152 79513348
Tenosynovitis stenosans 21.10 20.07 33 212855 3045 79528455
Cholecystitis acute 21.05 20.07 5 212883 13446 79518054
Benign prostatic hyperplasia 21.00 20.07 3 212885 11609 79519891
Escherichia infection 20.87 20.07 11 212877 18006 79513494
Central nervous system lesion 20.86 20.07 5 212883 13363 79518137
Dizziness postural 20.84 20.07 3 212885 11546 79519954
Incontinence 20.77 20.07 6 212882 14158 79517342
Finger deformity 20.72 20.07 55 212833 7419 79524081
Prolonged pregnancy 20.72 20.07 7 212881 44 79531456
Synovial disorder 20.68 20.07 26 212862 1957 79529543
Seasonal allergy 20.56 20.07 9 212879 16397 79515103
Facial pain 20.54 20.07 4 212884 12346 79519154
Osteonecrosis 20.51 20.07 32 212856 31063 79500437
Pollakiuria 20.50 20.07 43 212845 37274 79494226
Swelling face 20.49 20.07 109 212779 71103 79460397
Rheumatic disorder 20.47 20.07 33 212855 3125 79528375
Eye pruritus 20.45 20.07 15 212873 20555 79510945
Gestational diabetes 20.25 20.07 49 212839 6244 79525256

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AB05 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Tumor necrosis factor alpha (TNF-alpha) inhibitors
FDA MoA N0000175451 Tumor Necrosis Factor Receptor Blocking Activity
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D000079424 Tumor Necrosis Factor Inhibitors
FDA EPC N0000175610 Tumor Necrosis Factor Blocker

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Rheumatoid arthritis indication 69896004 DOID:7148
Psoriatic arthritis indication 156370009 DOID:9008
Plaque psoriasis indication 200965009
Pustular psoriasis indication 200973000
Erythrodermic psoriasis indication 200977004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Tumor necrosis factor Cytokine ANTIBODY BINDING Kd 10.05 DRUG LABEL DRUG LABEL

External reference:

IDSource
D03441 KEGG_DRUG
4028807 VUID
N0000178499 NUI
4027433 VANDF
4028807 VANDF
CHEMBL1201831 ChEMBL_ID
6774 IUPHAR_LIGAND_ID
DB08904 DRUGBANK_ID
709271 RXNORM
136438 MMSL
25282 MMSL
d07134 MMSL
012650 NDDF
430306004 SNOMEDCT_US
430307008 SNOMEDCT_US
D000068582 MESH_DESCRIPTOR_UI
C1872109 UMLSCUI
CHEMBL4297565 ChEMBL_ID
8448 INN_ID
UMD07X179E UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cimzia HUMAN PRESCRIPTION DRUG LABEL 1 50474-710 INJECTION, SOLUTION 200 mg SUBCUTANEOUS BLA 33 sections
Cimzia HUMAN PRESCRIPTION DRUG LABEL 1 50474-710 INJECTION, SOLUTION 200 mg SUBCUTANEOUS BLA 33 sections