etanercept 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
Tumour Necrosis Factor (TNF) receptors 4978 185243-69-0

Description:

MoleculeDescription

Synonyms:

  • etanercept-szzs
  • erelzi
  • etanercept
  • enbrel
  • TNR 001
  • TNR-001
  • etanercept (genetical recombination)
A recombinant version of soluble human TNF receptor fused to an IgG FC fragment that binds specifically to TUMOR NECROSIS FACTOR and inhibits its binding with endogenous TNF receptors. It prevents the inflammatory effect of TNF and is used to treat RHEUMATOID ARTHRITIS; PSORIATIC ARTHRITIS and ANKYLOSING SPONDYLITIS.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
7 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Jan. 19, 2005 PMDA WYETH LEDERLE JAPAN, WYETH
Nov. 2, 1998 FDA IMMUNEX
Feb. 3, 2000 EMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Injection site erythema 39382.65 12.47 21520 1232742 76982 89297203
Injection site pain 35844.60 12.47 24869 1229393 148830 89225355
Injection site pruritus 21987.59 12.47 11943 1242319 41891 89332294
Injection site swelling 20315.72 12.47 11759 1242503 48080 89326105
Injection site reaction 14452.35 12.47 11198 1243064 80882 89293303
Injection site bruising 12598.14 12.47 8261 1246001 44046 89330139
Injection site warmth 11792.81 12.47 5458 1248804 12057 89362128
Drug ineffective 7928.53 12.47 38845 1215417 1345453 88028732
Injection site rash 6277.45 12.47 4005 1250257 20168 89354017
Wrong technique in product usage process 5558.98 12.47 5861 1248401 65710 89308475
Arthralgia 5485.85 12.47 23271 1230991 755251 88618934
Injection site haemorrhage 5308.87 12.47 3835 1250427 24483 89349702
Injection site urticaria 5220.38 12.47 3200 1251062 14811 89359374
Joint swelling 3588.64 12.47 15117 1239145 488183 88886002
Therapeutic product effect decreased 3561.52 12.47 10142 1244120 267429 89106756
Injection site discolouration 3338.38 12.47 1899 1252363 7421 89366764
Injection site induration 3255.24 12.47 1946 1252316 8522 89365663
Acute kidney injury 3016.49 12.47 426 1253836 319961 89054224
Pain in extremity 2856.49 12.47 13069 1241193 437460 88936725
Toxicity to various agents 2817.17 12.47 338 1253924 287508 89086677
Drug interaction 2734.38 12.47 313 1253949 276140 89098045
Hypotension 2583.77 12.47 659 1253603 324738 89049447
Pain 2535.86 12.47 22894 1231368 973447 88400738
Product storage error 2421.88 12.47 2105 1252157 18136 89356049
Therapeutic product effect incomplete 2387.18 12.47 6984 1247278 186912 89187273
Anaemia 2328.53 12.47 984 1253278 351818 89022367
Death 2280.30 12.47 1789 1252473 454762 88919423
Device issue 2097.27 12.47 2308 1251954 27229 89346956
Nasopharyngitis 2004.55 12.47 10999 1243263 396105 88978080
Febrile neutropenia 1969.60 12.47 46 1254216 158303 89215882
Accidental exposure to product 1959.59 12.47 2666 1251596 39700 89334485
Injection site mass 1958.88 12.47 1944 1252318 20146 89354039
Sinusitis 1935.16 12.47 9627 1244635 333461 89040724
Completed suicide 1930.62 12.47 13 1254249 145045 89229140
Treatment failure 1839.27 12.47 8703 1245559 295225 89078960
Neutropenia 1736.16 12.47 481 1253781 224423 89149762
Constipation 1728.35 12.47 860 1253402 279535 89094650
Musculoskeletal stiffness 1649.73 12.47 8290 1245972 288242 89085943
Swelling 1605.58 12.47 10607 1243655 408451 88965734
Contraindicated product administered 1588.26 12.47 8670 1245592 311469 89062716
Dyspnoea 1482.82 12.47 6717 1247545 874238 88499947
Drug intolerance 1476.68 12.47 10924 1243338 436667 88937518
Hyponatraemia 1463.51 12.47 98 1254164 133440 89240745
Therapy interrupted 1445.78 12.47 2535 1251727 47573 89326612
Malignant neoplasm progression 1419.93 12.47 10 1254252 106860 89267325
Injection site haematoma 1406.56 12.47 985 1253277 5937 89368248
Disease progression 1330.31 12.47 273 1253989 156342 89217843
Thrombocytopenia 1301.33 12.47 630 1253632 208095 89166090
Diarrhoea 1299.52 12.47 7659 1246603 931531 88442654
Dehydration 1276.00 12.47 546 1253716 193901 89180284
Intentional overdose 1191.66 12.47 21 1254241 93813 89280372
Arthropathy 1163.60 12.47 8862 1245400 357380 89016805
Injection site discomfort 1162.30 12.47 826 1253436 5114 89369071
Product dose omission issue 1154.66 12.47 7447 1246815 284240 89089945
Abdominal pain 1125.38 12.47 2370 1251892 393351 88980834
Mobility decreased 1101.02 12.47 6575 1247687 244159 89130026
Cardiac arrest 1093.49 12.47 97 1254165 104838 89269347
Therapeutic response decreased 1081.89 12.47 3210 1251052 86519 89287666
Seizure 1078.25 12.47 382 1253880 152247 89221938
Vomiting 1023.03 12.47 6555 1247707 781738 88592447
Synovitis 1013.66 12.47 7919 1246343 321833 89052352
Somnolence 1000.35 12.47 853 1253409 208231 89165954
Bradycardia 966.42 12.47 46 1254216 83801 89290384
Pancytopenia 966.26 12.47 237 1254025 120026 89254159
Musculoskeletal pain 960.51 12.47 4801 1249461 166450 89207735
Oxygen saturation decreased 947.31 12.47 171 1254091 107312 89266873
Electrocardiogram QT prolonged 938.05 12.47 12 1254250 72444 89301741
Hypokalaemia 928.11 12.47 327 1253935 130789 89243396
Tachycardia 911.71 12.47 524 1253738 157149 89217036
Drug abuse 900.53 12.47 61 1254201 82286 89291899
Haemoglobin decreased 898.94 12.47 565 1253697 161391 89212794
Musculoskeletal disorder 870.40 12.47 1278 1252984 20491 89353694
Suicide attempt 845.02 12.47 49 1254213 75350 89298835
Injection site recall reaction 844.76 12.47 287 1253975 123 89374062
Injection site extravasation 839.21 12.47 815 1253447 8204 89365981
Respiratory failure 833.59 12.47 298 1253964 118120 89256065
Depressed level of consciousness 819.70 12.47 46 1254216 72738 89301447
Peripheral swelling 818.04 12.47 9028 1245234 404078 88970107
Injection site macule 813.50 12.47 302 1253960 255 89373930
Joint stiffness 811.32 12.47 2652 1251610 75390 89298795
Hyperkalaemia 799.49 12.47 21 1254241 64943 89309242
Pulmonary embolism 798.31 12.47 406 1253856 130414 89243771
Nausea 795.11 12.47 10720 1243542 1099596 88274589
Hypoxia 776.23 12.47 59 1254203 72340 89301845
Platelet count decreased 759.87 12.47 478 1253784 136491 89237694
Product use in unapproved indication 751.18 12.47 2277 1251985 333959 89040226
Gastrointestinal haemorrhage 750.48 12.47 165 1254097 90083 89284102
Arthritis 745.10 12.47 4405 1249857 162910 89211275
Renal failure 736.74 12.47 450 1253812 130557 89243628
Neutrophil count decreased 719.22 12.47 76 1254186 71456 89302729
Infection 712.33 12.47 7904 1246358 354190 89019995
Hypoglycaemia 700.26 12.47 75 1254187 69773 89304412
Syncope 683.75 12.47 502 1253760 132161 89242024
Drug hypersensitivity 682.00 12.47 9584 1244678 454025 88920160
Sepsis 680.34 12.47 894 1253368 178920 89195265
Multiple sclerosis relapse 671.26 12.47 10 1254252 52295 89321890
Cardio-respiratory arrest 661.50 12.47 57 1254205 63083 89311102
Coma 661.07 12.47 106 1254156 72526 89301659
Agitation 652.76 12.47 80 1254182 67018 89307167
Lactic acidosis 646.12 12.47 10 1254252 50453 89323732
Tremor 641.72 12.47 703 1253559 152470 89221715
Weight decreased 639.91 12.47 2891 1251371 377019 88997166
Atrial fibrillation 634.11 12.47 549 1253713 133062 89241123
Underdose 625.05 12.47 1905 1252357 52112 89322073
Blood pressure increased 621.76 12.47 1110 1253152 196107 89178078
Metabolic acidosis 621.41 12.47 37 1254225 55639 89318546
Deep vein thrombosis 620.64 12.47 245 1254017 91375 89282810
Alopecia 609.47 12.47 9928 1244334 485143 88889042
Overdose 609.08 12.47 772 1253490 156937 89217248
Sedation 602.65 12.47 13 1254249 48158 89326027
Red blood cell sedimentation rate abnormal 597.56 12.47 1145 1253117 23059 89351126
Cardiac failure 595.19 12.47 391 1253871 109105 89265080
Injection site irritation 594.59 12.47 562 1253700 5453 89368732
Fear of injection 591.62 12.47 658 1253604 7857 89366328
Injury associated with device 588.63 12.47 491 1253771 3973 89370212
Rhabdomyolysis 587.83 12.47 29 1254233 51227 89322958
Hallucination 587.57 12.47 102 1254160 65857 89308328
Nodule 584.86 12.47 1201 1253061 25485 89348700
Heart rate increased 575.64 12.47 432 1253830 112470 89261715
Surgery 570.78 12.47 1637 1252625 43250 89330935
Asthenia 566.98 12.47 4695 1249567 529056 88845129
Blood pressure decreased 566.77 12.47 166 1254096 74729 89299456
Knee arthroplasty 556.86 12.47 2456 1251806 80726 89293459
Neoplasm progression 556.56 12.47 12 1254250 44474 89329711
Device expulsion 542.16 12.47 4 1254258 40882 89333303
White blood cell count decreased 541.75 12.47 924 1253338 166185 89208000
Myelosuppression 541.19 12.47 56 1254206 53535 89320650
International normalised ratio increased 532.50 12.47 30 1254232 47286 89326899
Pleural effusion 531.61 12.47 460 1253802 111531 89262654
Neuropathy peripheral 531.48 12.47 668 1253594 136302 89237883
Hypersensitivity 524.16 12.47 9022 1245240 445655 88928530
Decreased appetite 517.52 12.47 3072 1251190 373468 89000717
Multiple organ dysfunction syndrome 510.67 12.47 155 1254107 68181 89306004
Incorrect dose administered by device 508.76 12.47 505 1253757 5232 89368953
Respiratory tract congestion 508.35 12.47 1153 1253109 26257 89347928
Bronchitis 505.72 12.47 3738 1250524 149189 89224996
Pulmonary oedema 505.14 12.47 119 1254143 61961 89312224
Haematochezia 499.78 12.47 178 1254084 70735 89303450
Hyperglycaemia 497.71 12.47 60 1254202 50910 89323275
Skin plaque 485.97 12.47 644 1253618 9331 89364854
Condition aggravated 485.76 12.47 11218 1243044 584327 88789858
Dysarthria 483.65 12.47 85 1254177 54397 89319788
Hand deformity 481.79 12.47 6240 1248022 290122 89084063
Serotonin syndrome 478.86 12.47 9 1254253 37878 89336307
Suicidal ideation 478.48 12.47 211 1254051 73644 89300541
Injection site inflammation 475.30 12.47 438 1253824 4103 89370082
Fall 474.20 12.47 4322 1249940 477488 88896697
Encephalopathy 472.97 12.47 47 1254215 46397 89327788
Drug reaction with eosinophilia and systemic symptoms 472.42 12.47 30 1254232 42728 89331457
Blood bilirubin increased 464.36 12.47 36 1254226 43434 89330751
Ascites 464.18 12.47 57 1254205 47683 89326502
Drug dose omission by device 462.62 12.47 637 1253625 9594 89364591
Mental status changes 460.84 12.47 43 1254219 44636 89329549
Mucosal inflammation 458.06 12.47 116 1254146 57509 89316676
Dyspnoea exertional 456.65 12.47 214 1254048 72074 89302111
Systemic lupus erythematosus 455.88 12.47 7287 1246975 354609 89019576
Anxiety 453.18 12.47 2476 1251786 307296 89066889
Cognitive disorder 450.11 12.47 198 1254064 69209 89304976
Orthostatic hypotension 448.61 12.47 34 1254228 41793 89332392
Blood creatinine increased 446.33 12.47 446 1253816 100940 89273245
Dizziness 446.15 12.47 5618 1248644 583666 88790519
Injection site vesicles 445.22 12.47 408 1253854 3792 89370393
Foetal exposure during pregnancy 433.71 12.47 45 1254217 42930 89331255
Palpitations 428.63 12.47 772 1253490 135956 89238229
Blood pressure systolic increased 422.33 12.47 140 1254122 58205 89315980
Unresponsive to stimuli 420.42 12.47 27 1254235 38094 89336091
Transplant dysfunction 419.34 12.47 438 1253824 4844 89369341
Flushing 416.92 12.47 366 1253896 88125 89286060
Cardiac failure congestive 415.47 12.47 451 1253811 98243 89275942
Hypomagnesaemia 415.05 12.47 18 1254244 35570 89338615
Unevaluable event 414.88 12.47 1681 1252581 53167 89321018
Pemphigus 411.34 12.47 6581 1247681 320283 89053902
Oropharyngeal pain 411.11 12.47 2868 1251394 112319 89261866
Chest discomfort 408.48 12.47 810 1253452 137555 89236630
Acute respiratory failure 405.84 12.47 56 1254206 42862 89331323
Off label use 404.89 12.47 11896 1242366 1090356 88283829
Pneumonia aspiration 402.70 12.47 47 1254215 40893 89333292
Drug ineffective for unapproved indication 395.89 12.47 214 1254048 66430 89307755
Dysphagia 392.90 12.47 590 1253672 111688 89262497
Psoriasis 392.33 12.47 3435 1250827 144319 89229866
Hepatic function abnormal 386.08 12.47 84 1254178 46204 89327981
Herpes zoster 385.15 12.47 2435 1251827 92209 89281976
Cerebrovascular accident 384.98 12.47 700 1253562 122833 89251352
Angioedema 384.39 12.47 209 1254053 64667 89309518
Colitis 371.69 12.47 256 1254006 69686 89304499
Heart rate decreased 369.11 12.47 139 1254123 53366 89320819
Paranasal sinus hypersecretion 367.79 12.47 381 1253881 4170 89370015
Respiratory arrest 366.16 12.47 24 1254238 33287 89340898
Renal impairment 364.03 12.47 559 1253703 104862 89269323
Influenza 354.99 12.47 3209 1251053 136055 89238130
Melaena 354.90 12.47 35 1254227 34762 89339423
Respiratory distress 354.03 12.47 57 1254205 38889 89335296
Cholestasis 353.75 12.47 43 1254219 36256 89337929
Hypervolaemia 353.09 12.47 26 1254236 32731 89341454
Pharyngitis streptococcal 346.05 12.47 628 1253634 12114 89362071
Drug level increased 345.30 12.47 8 1254254 27754 89346431
Osteonecrosis of jaw 344.93 12.47 62 1254200 39041 89335144
Intentional self-injury 344.89 12.47 14 1254248 29320 89344865
Blood glucose increased 344.53 12.47 489 1253773 94757 89279428
Cytokine release syndrome 344.34 12.47 9 1254253 27964 89346221
Blood alkaline phosphatase increased 343.41 12.47 118 1254144 47961 89326224
Plasma cell myeloma 342.75 12.47 73 1254189 40755 89333430
Lymphocyte count decreased 340.40 12.47 42 1254220 35008 89339177
Therapy non-responder 340.32 12.47 3134 1251128 133570 89240615
Toxic epidermal necrolysis 338.99 12.47 30 1254232 32498 89341687
COVID-19 337.52 12.47 1200 1253062 167643 89206542
Rectal haemorrhage 335.29 12.47 390 1253872 82354 89291831
Disorientation 335.18 12.47 97 1254165 44017 89330168
Finger deformity 334.68 12.47 1110 1253152 31787 89342398
No adverse event 333.97 12.47 270 1253992 67712 89306473
Abdominal discomfort 332.39 12.47 8803 1245459 468525 88905660
Chest pain 324.34 12.47 2844 1251418 316801 89057384
Aphasia 323.71 12.47 95 1254167 42717 89331468
Psychotic disorder 322.24 12.47 30 1254232 31200 89342985
Glossodynia 321.92 12.47 6247 1248015 315532 89058653
Pulmonary hypertension 318.53 12.47 96 1254166 42427 89331758
Urinary retention 317.85 12.47 67 1254195 37677 89336508
Alanine aminotransferase increased 317.41 12.47 731 1253531 117607 89256578
Altered state of consciousness 315.68 12.47 34 1254228 31498 89342687
Drug withdrawal syndrome 314.82 12.47 21 1254241 28702 89345483
Injection site hypersensitivity 314.44 12.47 276 1253986 2411 89371774
Myalgia 313.75 12.47 1301 1252961 173824 89200361
Exposure during pregnancy 312.14 12.47 1974 1252288 236436 89137749
C-reactive protein abnormal 307.46 12.47 2902 1251360 124527 89249658
Generalised tonic-clonic seizure 306.45 12.47 56 1254206 34847 89339338
Hepatic cytolysis 305.31 12.47 35 1254227 30881 89343304
Agranulocytosis 303.38 12.47 58 1254204 34944 89339241
Device dislocation 300.24 12.47 40 1254222 31442 89342743
Hepatic failure 298.84 12.47 89 1254173 39639 89334546
Chronic kidney disease 296.90 12.47 162 1254100 50029 89324156
Pulmonary arterial hypertension 296.54 12.47 16 1254246 26171 89348014
Balance disorder 296.36 12.47 557 1253705 96523 89277662
Inflammation 295.68 12.47 3774 1250488 174818 89199367
Blood calcium decreased 288.67 12.47 38 1254224 30144 89344041
Aspartate aminotransferase increased 288.24 12.47 621 1253641 102316 89271869
Blood creatine phosphokinase increased 287.32 12.47 60 1254202 33963 89340222
Bone marrow failure 286.58 12.47 50 1254212 32171 89342014
Ventricular tachycardia 286.49 12.47 13 1254249 24695 89349490
Blood pressure fluctuation 286.36 12.47 186 1254076 52227 89321958
Impaired healing 284.93 12.47 4690 1249572 229509 89144676
Haematemesis 283.73 12.47 60 1254202 33666 89340519
Gamma-glutamyltransferase increased 283.70 12.47 86 1254176 37866 89336319
Asthma 283.22 12.47 2073 1252189 240087 89134098
Red blood cell sedimentation rate increased 271.81 12.47 2017 1252245 80578 89293607
Neurotoxicity 271.71 12.47 5 1254257 21462 89352723
Dermatitis atopic 270.04 12.47 13 1254249 23459 89350726
Loss of personal independence in daily activities 269.72 12.47 2977 1251285 133128 89241057
Pancreatitis acute 268.41 12.47 58 1254204 32057 89342128
Cardiogenic shock 267.85 12.47 18 1254244 24450 89349735
Jaundice 267.18 12.47 61 1254201 32456 89341729
Stevens-Johnson syndrome 267.01 12.47 43 1254219 29333 89344852
Acute myocardial infarction 266.41 12.47 76 1254186 34814 89339371
Hepatocellular injury 266.35 12.47 41 1254221 28917 89345268
Sinus tachycardia 265.40 12.47 39 1254223 28474 89345711
Hemiparesis 264.85 12.47 58 1254204 31761 89342424
Acute hepatic failure 264.47 12.47 11 1254251 22550 89351635
Shock 264.11 12.47 41 1254221 28737 89345448
Therapy cessation 262.82 12.47 1099 1253163 35262 89338923
Eosinophilia 261.07 12.47 41 1254221 28492 89345693
Full blood count decreased 259.88 12.47 48 1254214 29641 89344544
Lethargy 258.61 12.47 295 1253967 62844 89311341
Diabetic ketoacidosis 258.49 12.47 21 1254241 24386 89349799
Posterior reversible encephalopathy syndrome 258.21 12.47 12 1254250 22327 89351858
Adverse reaction 255.99 12.47 949 1253313 28763 89345422
Arrhythmia 254.26 12.47 134 1254128 42198 89331987
Rheumatoid nodule 253.00 12.47 732 1253530 19434 89354751
Electrolyte imbalance 252.68 12.47 20 1254242 23725 89350460
Foot operation 252.58 12.47 450 1253812 8551 89365634
Foot deformity 252.20 12.47 1550 1252712 58101 89316084
Withdrawal syndrome 251.25 12.47 15 1254247 22509 89351676
Obstructive airways disorder 251.22 12.47 31 1254231 25838 89348347
Leukocytosis 250.93 12.47 60 1254202 30930 89343255
Hepatic enzyme increased 249.18 12.47 6647 1247615 354089 89020096
Upper gastrointestinal haemorrhage 248.33 12.47 18 1254244 22958 89351227
Pneumonia 248.08 12.47 6828 1247434 631231 88742954
Premature delivery 247.52 12.47 113 1254149 38649 89335536
Aggression 247.02 12.47 37 1254225 26631 89347554
Confusional state 246.45 12.47 3809 1250453 382396 88991789
Septic shock 246.35 12.47 495 1253767 83665 89290520
Inappropriate antidiuretic hormone secretion 245.03 12.47 5 1254257 19500 89354685
Leukopenia 242.88 12.47 657 1253605 100053 89274132
Blood urea increased 242.13 12.47 61 1254201 30352 89343833
Ejection fraction decreased 241.85 12.47 37 1254225 26216 89347969
Tuberculin test positive 240.33 12.47 277 1253985 3448 89370737
Haemorrhage 238.35 12.47 369 1253893 69000 89305185
Tachypnoea 238.27 12.47 14 1254248 21295 89352890
Epistaxis 237.94 12.47 514 1253748 84611 89289574
Blood potassium decreased 237.63 12.47 187 1254075 47540 89326645
Loss of consciousness 236.99 12.47 1065 1253197 139173 89235012
Status epilepticus 236.46 12.47 5 1254257 18869 89355316
Contusion 234.69 12.47 4828 1249434 246388 89127797
Accidental overdose 234.39 12.47 52 1254210 28221 89345964
Circulatory collapse 234.28 12.47 33 1254229 24871 89349314
Cerebral haemorrhage 234.28 12.47 92 1254170 34430 89339755
Rash 234.04 12.47 13354 1240908 782746 88591439
Infusion site pain 233.48 12.47 9 1254253 19729 89354456
Shoulder arthroplasty 232.92 12.47 288 1253974 3878 89370307
Increased tendency to bruise 231.50 12.47 510 1253752 11380 89362805
Blood lactate dehydrogenase increased 231.16 12.47 40 1254222 25892 89348293
Coronary artery disease 230.83 12.47 88 1254174 33535 89340650
Gait disturbance 229.61 12.47 4964 1249298 255532 89118653
Haematoma 229.56 12.47 127 1254135 38921 89335264
Disturbance in attention 229.03 12.47 189 1254073 46920 89327265
Small intestinal obstruction 228.45 12.47 17 1254245 21217 89352968
Injection site nodule 227.53 12.47 295 1253967 4178 89370007
Sinus headache 226.06 12.47 357 1253905 6119 89368066
Hallucination, visual 225.90 12.47 27 1254235 23065 89351120
Rash maculo-papular 225.34 12.47 144 1254118 40789 89333396
Blood pressure diastolic decreased 225.11 12.47 48 1254214 26778 89347407
Ear infection 225.09 12.47 1696 1252566 68079 89306106
Pyrexia 220.81 12.47 7213 1247049 653272 88720913
Blood pressure diastolic abnormal 216.53 12.47 15 1254247 19866 89354319
Dyskinesia 215.98 12.47 118 1254144 36416 89337769
Urinary incontinence 215.37 12.47 126 1254136 37440 89336745
Antibiotic therapy 213.97 12.47 161 1254101 1102 89373083
Neck pain 213.68 12.47 2466 1251796 111497 89262688
Metastases to bone 213.28 12.47 46 1254216 25459 89348726
Restlessness 213.17 12.47 114 1254148 35606 89338579
Macular degeneration 212.58 12.47 131 1254131 37839 89336346
Neutropenic sepsis 211.98 12.47 9 1254253 18121 89356064
Clostridium difficile colitis 211.78 12.47 54 1254208 26652 89347533
Paraesthesia oral 210.55 12.47 87 1254175 31572 89342613
Pericardial effusion 210.52 12.47 124 1254138 36709 89337476
Chondrolysis 208.48 12.47 90 1254172 155 89374030
Cholelithiasis 207.88 12.47 252 1254010 52254 89321931
Rheumatoid factor positive 207.78 12.47 3435 1250827 168215 89205970
Emotional distress 207.33 12.47 125 1254137 36537 89337648
Blood iron abnormal 205.86 12.47 266 1253996 3754 89370431
Right ventricular failure 204.85 12.47 16 1254246 19189 89354996
Gastrooesophageal reflux disease 204.62 12.47 1403 1252859 164934 89209251
Knee operation 204.00 12.47 354 1253908 6582 89367603
Hypocalcaemia 202.25 12.47 173 1254089 42195 89331990
Wound 200.94 12.47 5554 1248708 297426 89076759
Respiratory depression 199.75 12.47 3 1254259 15572 89358613
Bacteraemia 199.66 12.47 34 1254228 22266 89351919
Tubulointerstitial nephritis 199.52 12.47 52 1254210 25291 89348894
Coagulopathy 198.88 12.47 40 1254222 23249 89350936
Rubber sensitivity 198.41 12.47 220 1254042 2617 89371568
Full blood count abnormal 198.39 12.47 131 1254131 36466 89337719
Device difficult to use 196.12 12.47 611 1253651 16914 89357271
Thrombosis 195.98 12.47 453 1253809 72798 89301387
Joint destruction 195.20 12.47 511 1253751 12776 89361409
Myoclonus 193.60 12.47 20 1254242 19148 89355037
Neuroleptic malignant syndrome 193.21 12.47 3 1254259 15093 89359092
Oedema 193.02 12.47 1805 1252457 198490 89175695
Angina pectoris 191.75 12.47 156 1254106 39004 89335181
Abnormal behaviour 190.88 12.47 40 1254222 22588 89351597
Acute respiratory distress syndrome 190.50 12.47 79 1254183 28607 89345578
Adverse drug reaction 189.21 12.47 2457 1251805 114244 89259941
Cerebral infarction 188.68 12.47 66 1254196 26530 89347655
Extrapyramidal disorder 187.65 12.47 9 1254253 16294 89357891
Treatment noncompliance 187.61 12.47 265 1253997 51462 89322723
Breast cancer 187.28 12.47 1331 1252931 52430 89321755
Haematuria 186.78 12.47 127 1254135 34810 89339375
Female genital tract fistula 184.79 12.47 17 1254245 17851 89356334
Hypothermia 184.58 12.47 7 1254255 15568 89358617
Demyelination 183.87 12.47 371 1253891 7769 89366416
Vision blurred 183.70 12.47 842 1253420 109451 89264734
Cytomegalovirus infection 183.66 12.47 69 1254193 26533 89347652
Therapeutic product effect delayed 183.45 12.47 239 1254023 3402 89370783
Upper respiratory tract infection 182.90 12.47 2640 1251622 125678 89248507
Dystonia 182.28 12.47 13 1254249 16806 89357379
Lymphopenia 180.03 12.47 47 1254215 22834 89351351
Hip arthroplasty 179.52 12.47 1727 1252535 74481 89299704
Labelled drug-drug interaction medication error 178.34 12.47 5 1254257 14577 89359608
Face oedema 177.65 12.47 51 1254211 23267 89350918
Proctitis 177.01 12.47 8 1254254 15251 89358934
Oedema peripheral 176.76 12.47 2508 1251754 255407 89118778
Premature baby 176.59 12.47 63 1254199 25014 89349171
Hypothyroidism 176.47 12.47 289 1253973 52838 89321347
Sinus bradycardia 175.66 12.47 16 1254246 16936 89357249
Cyanosis 175.65 12.47 29 1254233 19426 89354759
Haematocrit decreased 175.09 12.47 192 1254070 41640 89332545
Anuria 174.45 12.47 7 1254255 14811 89359374
Blood sodium decreased 173.98 12.47 82 1254180 27531 89346654
Blood pressure systolic abnormal 173.72 12.47 30 1254232 19448 89354737
Fluid retention 173.37 12.47 630 1253632 87461 89286724
Intestinal obstruction 173.15 12.47 155 1254107 36976 89337209
Localised infection 172.65 12.47 919 1253343 32643 89341542
Frequent bowel movements 172.57 12.47 328 1253934 56607 89317578
Eczema 172.46 12.47 291 1253971 52579 89321606
Presyncope 172.20 12.47 114 1254148 31691 89342494
Parkinsonism 171.36 12.47 5 1254257 14060 89360125
Metastases to central nervous system 170.39 12.47 21 1254241 17521 89356664
Product prescribing error 170.16 12.47 103 1254159 30042 89344143
Infusion site erythema 169.78 12.47 4 1254258 13666 89360519
Subdural haematoma 169.07 12.47 17 1254245 16628 89357557
Anti-cyclic citrullinated peptide antibody positive 168.98 12.47 4377 1249885 232056 89142129
Arthropod bite 167.25 12.47 373 1253889 8394 89365791
Poisoning 167.14 12.47 11 1254251 15206 89358979
Cytopenia 166.80 12.47 22 1254240 17427 89356758
Brain oedema 165.99 12.47 22 1254240 17363 89356822
Myocardial infarction 165.98 12.47 827 1253435 105145 89269040
Corrective lens user 165.55 12.47 78 1254184 182 89374003
Flatulence 165.40 12.47 197 1254065 41170 89333015
Ill-defined disorder 164.66 12.47 3529 1250733 181362 89192823
Renal tubular necrosis 164.48 12.47 9 1254253 14546 89359639
Ischaemic stroke 164.29 12.47 51 1254211 22115 89352070
Metastases to liver 163.20 12.47 98 1254164 28709 89345476
Adverse event 163.10 12.47 2405 1251857 115013 89259172
Gastritis 162.54 12.47 203 1254059 41550 89332635
Depression 162.05 12.47 3056 1251206 297545 89076640
Grip strength decreased 161.98 12.47 1977 1252285 90599 89283586
Troponin increased 160.79 12.47 5 1254257 13276 89360909
Osteoarthritis 159.83 12.47 3690 1250572 192040 89182145
Chronic obstructive pulmonary disease 158.88 12.47 508 1253754 73321 89300864
Abdominal distension 158.42 12.47 1106 1253156 129495 89244690
Joint injury 158.31 12.47 880 1253382 31784 89342401
Tooth infection 157.96 12.47 625 1253637 19545 89354640
Device failure 157.76 12.47 316 1253946 6581 89367604
Injection site injury 157.48 12.47 122 1254140 877 89373308
Joint arthroplasty 156.47 12.47 216 1254046 3261 89370924
Speech disorder 156.10 12.47 243 1254019 45342 89328843
Product dose omission in error 155.91 12.47 45 1254217 20458 89353727
Transfusion 155.83 12.47 27 1254235 17461 89356724
Haemorrhage intracranial 155.28 12.47 15 1254247 15147 89359038
Shock haemorrhagic 154.38 12.47 3 1254259 12242 89361943
COVID-19 pneumonia 153.60 12.47 32 1254230 18145 89356040
Complication associated with device 152.93 12.47 40 1254222 19409 89354776
Schizophrenia 152.09 12.47 15 1254247 14899 89359286
Ataxia 151.97 12.47 32 1254230 18010 89356175
Mycobacterium tuberculosis complex test positive 151.58 12.47 184 1254078 2428 89371757
Gastroenteritis 151.31 12.47 110 1254152 29119 89345066
Respiratory rate increased 151.00 12.47 21 1254241 15980 89358205
Mydriasis 150.75 12.47 16 1254246 14996 89359189
Mania 150.00 12.47 12 1254250 14112 89360073
Acidosis 149.99 12.47 6 1254256 12730 89361455
Joint effusion 149.75 12.47 605 1253657 19105 89355080
Hypoalbuminaemia 149.69 12.47 21 1254241 15876 89358309
Personality disorder 149.54 12.47 5 1254257 12439 89361746
Haemoptysis 148.42 12.47 145 1254117 33175 89341010
Thrombotic microangiopathy 147.77 12.47 21 1254241 15722 89358463
Acute generalised exanthematous pustulosis 147.34 12.47 11 1254251 13692 89360493
Joint warmth 146.89 12.47 150 1254112 1612 89372573
Diabetes mellitus inadequate control 145.82 12.47 39 1254223 18645 89355540
Pancreatitis 145.04 12.47 488 1253774 69338 89304847
Haematotoxicity 144.02 12.47 7 1254255 12528 89361657
Hemiplegia 143.88 12.47 25 1254237 16135 89358050
Anhedonia 143.31 12.47 3 1254259 11428 89362757
Abdominal pain lower 143.10 12.47 124 1254138 30053 89344132
Dysgeusia 143.07 12.47 322 1253940 52238 89321947
Myelodysplastic syndrome 143.01 12.47 55 1254207 20848 89353337
Malnutrition 142.47 12.47 40 1254222 18518 89355667
Ventricular fibrillation 140.95 12.47 15 1254247 14029 89360156
Tricuspid valve incompetence 140.26 12.47 30 1254232 16701 89357484
Infusion site swelling 139.81 12.47 5 1254257 11715 89362470
Lower respiratory tract infection 139.33 12.47 4496 1249766 246163 89128022
Hypertension 138.63 12.47 5057 1249205 452475 88921710
Sleep disorder due to general medical condition, insomnia type 137.23 12.47 2524 1251738 126170 89248015
Muscle rigidity 136.88 12.47 18 1254244 14291 89359894
Deformity 136.83 12.47 425 1253837 11745 89362440
Tardive dyskinesia 136.51 12.47 3 1254259 10927 89363258
Injection site papule 136.47 12.47 108 1254154 804 89373381
Transient ischaemic attack 135.95 12.47 243 1254019 42933 89331252
Acute myeloid leukaemia 135.20 12.47 58 1254204 20582 89353603
Therapy partial responder 135.02 12.47 68 1254194 21975 89352210
Chronic sinusitis 134.80 12.47 81 1254181 23721 89350464
Left ventricular dysfunction 134.38 12.47 21 1254241 14648 89359537
Clostridium difficile infection 134.13 12.47 183 1254079 36062 89338123
Haemodynamic instability 133.46 12.47 7 1254255 11732 89362453
Pharyngitis 131.94 12.47 628 1253634 21319 89352866
Vaginal discharge 131.86 12.47 52 1254210 19412 89354773
Colitis ulcerative 131.55 12.47 412 1253850 59854 89314331
Malaise 131.47 12.47 9608 1244654 576378 88797807
Transaminases increased 131.46 12.47 194 1254068 36998 89337187
Toxic skin eruption 130.78 12.47 29 1254233 15745 89358440
Acne 130.25 12.47 756 1253506 27751 89346434
Vascular device infection 130.22 12.47 9 1254253 11943 89362242
Supraventricular tachycardia 129.59 12.47 33 1254229 16303 89357882
Poor venous access 129.31 12.47 54 1254208 19473 89354712
Sleep apnoea syndrome 129.27 12.47 149 1254113 31598 89342587
Joint fluid drainage 129.09 12.47 60 1254202 134 89374051
Pallor 128.97 12.47 170 1254092 33995 89340190
Joint lock 128.30 12.47 168 1254094 2404 89371781
Body temperature decreased 128.08 12.47 86 1254176 23730 89350455
Circumstance or information capable of leading to medication error 127.57 12.47 239 1254023 4728 89369457
Rales 127.44 12.47 31 1254231 15796 89358389
Nightmare 127.21 12.47 71 1254191 21654 89352531
Anaphylactic shock 127.01 12.47 150 1254112 31467 89342718
Delirium 126.94 12.47 883 1253379 103476 89270709
Disseminated intravascular coagulation 126.68 12.47 70 1254192 21468 89352717
Limb operation 126.61 12.47 226 1254036 4301 89369884
Ileus 126.40 12.47 36 1254226 16510 89357675
Affect lability 126.13 12.47 46 1254216 18017 89356168
Cardiomegaly 125.86 12.47 52 1254210 18873 89355312
Mitral valve incompetence 125.68 12.47 78 1254184 22446 89351739
Rhinitis allergic 125.52 12.47 38 1254224 16747 89357438
Lip swelling 125.48 12.47 213 1254049 38397 89335788
Hallucination, auditory 125.33 12.47 33 1254229 15942 89358243
Device malfunction 125.21 12.47 599 1253663 20378 89353807
Vertigo 124.72 12.47 519 1253743 69292 89304893
Joint noise 124.16 12.47 245 1254017 5045 89369140
Swollen tongue 123.90 12.47 283 1253979 45673 89328512
Subarachnoid haemorrhage 122.67 12.47 47 1254215 17857 89356328
Wheezing 122.28 12.47 2440 1251822 235640 89138545
Spinal operation 122.06 12.47 364 1253898 9832 89364353
Oliguria 121.85 12.47 6 1254256 10618 89363567
Osteonecrosis 121.81 12.47 110 1254152 26131 89348054
Aplastic anaemia 121.55 12.47 19 1254243 13250 89360935
Anal incontinence 120.90 12.47 37 1254225 16193 89357992
Pneumonitis 120.71 12.47 270 1253992 43900 89330285
Febrile bone marrow aplasia 120.36 12.47 3 1254259 9735 89364450
Glomerular filtration rate decreased 120.15 12.47 42 1254220 16890 89357295
Procedural pain 119.89 12.47 172 1254090 33188 89340997
Drug resistance 119.62 12.47 147 1254115 30302 89343883
Myocarditis 119.39 12.47 23 1254239 13783 89360402
Discomfort 118.43 12.47 4782 1249480 269553 89104632
Impaired work ability 118.37 12.47 556 1253706 18770 89355415
Tinnitus 118.18 12.47 263 1253999 42839 89331346
Jaundice cholestatic 117.37 12.47 5 1254257 10038 89364147
Intentional product misuse 117.33 12.47 1817 1252445 87787 89286398
Psoriatic arthropathy 117.03 12.47 4057 1250205 224278 89149907
Hyperhidrosis 116.87 12.47 1263 1252999 135042 89239143
Mental disorder 115.78 12.47 167 1254095 32151 89342034
Hypernatraemia 115.61 12.47 3 1254259 9384 89364801
Ear pain 115.56 12.47 1265 1252997 56437 89317748
Second primary malignancy 115.49 12.47 7 1254255 10371 89363814
Adjustment disorder 115.42 12.47 4 1254258 9638 89364547
Folliculitis 115.24 12.47 3672 1250590 200681 89173504
Infusion site extravasation 114.83 12.47 7 1254255 10321 89363864
Wrist surgery 114.47 12.47 99 1254163 846 89373339
Product administration interrupted 114.17 12.47 18 1254244 12474 89361711
Ovarian cyst 114.07 12.47 509 1253753 16809 89357376
Red blood cell count decreased 113.53 12.47 300 1253962 46051 89328134
Urine output decreased 113.31 12.47 19 1254243 12584 89361601
Decreased immune responsiveness 113.09 12.47 321 1253941 8427 89365758
Muscle injury 112.43 12.47 3222 1251040 173432 89200753
Rhinorrhoea 112.26 12.47 1782 1252480 86534 89287651
Stress cardiomyopathy 111.85 12.47 24 1254238 13331 89360854
Delusion 111.65 12.47 27 1254235 13813 89360372
Blood magnesium decreased 111.23 12.47 39 1254223 15654 89358531
Iritis 110.86 12.47 190 1254072 3496 89370689
Paranoia 110.58 12.47 22 1254240 12886 89361299
Complication of device insertion 110.46 12.47 9 1254253 10427 89363758
Blood loss anaemia 109.42 12.47 8 1254254 10132 89364053
Tumour lysis syndrome 109.18 12.47 13 1254249 11139 89363046
Radiculopathy 109.04 12.47 60 1254202 18445 89355740
Lower gastrointestinal haemorrhage 108.93 12.47 3 1254259 8889 89365296
Heart rate irregular 108.79 12.47 105 1254157 24163 89350022
Limb deformity 108.16 12.47 201 1254061 3951 89370234
Renal injury 107.95 12.47 9 1254253 10234 89363951
Nephropathy toxic 107.91 12.47 22 1254240 12666 89361519
Aspiration 107.84 12.47 41 1254221 15652 89358533
Myocardial ischaemia 107.50 12.47 29 1254233 13785 89360400
Bone erosion 107.39 12.47 1165 1253097 51856 89322329
Cardiac failure acute 107.21 12.47 18 1254244 11911 89362274
Chondropathy 107.01 12.47 152 1254110 2360 89371825
Irritability 106.72 12.47 207 1254055 35455 89338730
Lipase increased 106.23 12.47 14 1254248 11097 89363088
Deafness transitory 105.89 12.47 136 1254126 1907 89372278
Injection site laceration 105.86 12.47 45 1254217 73 89374112
Nasal polyps 105.74 12.47 13 1254249 10867 89363318
Rebound effect 105.43 12.47 6 1254256 9378 89364807
Pericarditis 104.85 12.47 4657 1249605 265494 89108691
Hypovolaemia 104.80 12.47 22 1254240 12409 89361776
Enterococcal infection 104.69 12.47 9 1254253 9982 89364203
Hyperthermia 103.82 12.47 11 1254251 10324 89363861
Atrioventricular block first degree 103.78 12.47 3 1254259 8508 89365677
Transplant rejection 103.69 12.47 400 1253862 12358 89361827
Klebsiella infection 103.34 12.47 11 1254251 10286 89363899
Apathy 102.98 12.47 15 1254247 11025 89363160
Fine motor skill dysfunction 102.75 12.47 230 1254032 5189 89368996
Cholecystitis chronic 102.56 12.47 9 1254253 9817 89364368
Acute coronary syndrome 102.49 12.47 14 1254248 10799 89363386
Haemolytic anaemia 102.18 12.47 19 1254243 11678 89362507
Proteinuria 101.85 12.47 103 1254159 23188 89350997
Drug level decreased 101.32 12.47 9 1254253 9721 89364464
Irritable bowel syndrome 101.13 12.47 3665 1250597 203783 89170402
Hospitalisation 100.80 12.47 1210 1253052 126890 89247295
Device related infection 100.76 12.47 125 1254137 25661 89348524
Motor dysfunction 100.02 12.47 72 1254190 19158 89355027
Fibromyalgia 100.02 12.47 3642 1250620 202627 89171558
Sinus congestion 99.64 12.47 686 1253576 26738 89347447
Bronchospasm 99.53 12.47 84 1254178 20625 89353560
Viral upper respiratory tract infection 99.38 12.47 304 1253958 8330 89365855
Hypophagia 98.75 12.47 219 1254043 35718 89338467
Bronchitis chronic 98.70 12.47 209 1254053 4534 89369651
Myopathy 98.59 12.47 32 1254230 13486 89360699
Injection site paraesthesia 98.58 12.47 80 1254182 620 89373565
Cardiac disorder 98.39 12.47 428 1253834 56444 89317741
Hospice care 98.33 12.47 10 1254252 9694 89364491
Cardiomyopathy 98.30 12.47 81 1254181 20125 89354060
Blood albumin decreased 98.26 12.47 55 1254207 16748 89357437
End stage renal disease 97.79 12.47 5 1254257 8566 89365619
Atelectasis 96.77 12.47 117 1254145 24292 89349893
Headache 95.88 12.47 13477 1240785 849269 88524916
Oesophagitis 95.88 12.47 60 1254202 17189 89356996
Joint range of motion decreased 95.63 12.47 2507 1251755 133136 89241049
Ventricular extrasystoles 95.52 12.47 32 1254230 13218 89360967
Eye disorder 95.32 12.47 678 1253584 26712 89347473
Hydronephrosis 94.71 12.47 27 1254235 12375 89361810
Blood lactic acid increased 94.51 12.47 7 1254255 8771 89365414
Device use error 94.35 12.47 266 1253996 6955 89367230
Oral candidiasis 94.24 12.47 220 1254042 35235 89338950
Prothrombin time prolonged 94.18 12.47 12 1254250 9760 89364425
Psychomotor hyperactivity 94.03 12.47 30 1254232 12783 89361402
Diplopia 93.69 12.47 158 1254104 28556 89345629
Arterial occlusive disease 93.39 12.47 28 1254234 12418 89361767
Arthrodesis 92.89 12.47 157 1254105 2855 89371330
Failure to thrive 92.62 12.47 6 1254256 8405 89365780
Vaginal haemorrhage 92.29 12.47 183 1254079 31088 89343097
Atrioventricular block complete 92.29 12.47 13 1254249 9798 89364387
Hypertransaminasaemia 92.25 12.47 52 1254210 15773 89358412
Chromaturia 92 12.47 78 1254184 19109 89355076
Metastases to lung 91.15 12.47 54 1254208 15937 89358248
Polyneuropathy 91.07 12.47 80 1254182 19261 89354924
Uterine perforation 90.90 12.47 3 1254259 7551 89366634
Dementia 90.81 12.47 118 1254144 23743 89350442
Drug dependence 90.59 12.47 167 1254095 29160 89345025
Furuncle 90.58 12.47 270 1253992 7291 89366894
Low birth weight baby 90.34 12.47 12 1254250 9455 89364730
Incorrect disposal of product 90.28 12.47 88 1254174 890 89373295
Anaphylactic reaction 90.27 12.47 775 1253487 86749 89287436
Sensory loss 89.75 12.47 71 1254191 18004 89356181
Chills 89.07 12.47 1287 1252975 130694 89243491
Tuberculosis 88.89 12.47 377 1253885 12172 89362013
Hypotonia 88.89 12.47 24 1254238 11402 89362783
Extra dose administered 88.61 12.47 303 1253959 8815 89365370
Increased upper airway secretion 88.43 12.47 177 1254085 3684 89370501
Blister 88.06 12.47 4345 1249917 250653 89123532
Faeces discoloured 87.96 12.47 99 1254163 21221 89352964
Enterocolitis 87.55 12.47 19 1254243 10471 89363714
Apnoea 87.33 12.47 13 1254249 9401 89364784
Acute pulmonary oedema 87.12 12.47 14 1254248 9566 89364619
Hyperthyroidism 87.10 12.47 75 1254187 18235 89355950
Eosinophil count increased 86.90 12.47 36 1254226 13045 89361140
Hepatitis acute 86.35 12.47 22 1254240 10865 89363320
Peritonitis 86.33 12.47 87 1254175 19618 89354567
General physical health deterioration 86.19 12.47 4025 1250237 351090 89023095
Blood potassium increased 85.99 12.47 96 1254166 20653 89353532
Product quality issue 85.61 12.47 694 1253568 78631 89295554
Depressed mood 84.44 12.47 382 1253880 49840 89324345
Erythema multiforme 84.14 12.47 32 1254230 12214 89361971
Skin ulcer 83.96 12.47 1061 1253201 49014 89325171
Respiratory acidosis 83.23 12.47 8 1254254 8111 89366074
Therapeutic response delayed 83.22 12.47 79 1254183 771 89373414
Gangrene 83.04 12.47 37 1254225 12839 89361346
Shoulder operation 83.02 12.47 147 1254115 2779 89371406
Ageusia 82.56 12.47 61 1254201 16015 89358170
Impaired quality of life 82.51 12.47 120 1254142 23024 89351161
Elbow deformity 82.14 12.47 103 1254159 1408 89372777
Abortion induced 81.79 12.47 31 1254231 11857 89362328
Haemodialysis 81.32 12.47 12 1254250 8735 89365450
Salivary hypersecretion 81.09 12.47 14 1254248 9078 89365107
Faecaloma 80.98 12.47 22 1254240 10409 89363776
Coordination abnormal 80.88 12.47 106 1254156 21250 89352935
Haemolysis 80.70 12.47 11 1254251 8499 89365686
Nephropathy 80.68 12.47 15 1254247 9220 89364965
Bradykinesia 80.61 12.47 3 1254259 6785 89367400
Middle insomnia 80.44 12.47 68 1254194 16683 89357502
Toothache 80.12 12.47 555 1253707 21675 89352510
Medication error 79.29 12.47 768 1253494 83884 89290301
Product complaint 79.22 12.47 44 1254218 13456 89360729
Haemorrhoids 79.03 12.47 156 1254106 26546 89347639
Neutrophil count increased 78.95 12.47 91 1254171 19299 89354886
Hepatomegaly 78.82 12.47 43 1254219 13283 89360902
Colitis ischaemic 78.81 12.47 36 1254226 12310 89361875
Bone pain 78.07 12.47 519 1253743 61464 89312721
Enteritis 77.84 12.47 23 1254239 10298 89363887
Rash pruritic 77.29 12.47 1582 1252680 80632 89293553
Limb discomfort 76.95 12.47 836 1253426 37224 89336961
Activated partial thromboplastin time prolonged 76.91 12.47 9 1254253 7816 89366369
Metabolic encephalopathy 76.84 12.47 4 1254258 6748 89367437
Cardiac murmur 76.70 12.47 83 1254179 18111 89356074
Cytomegalovirus viraemia 76.40 12.47 8 1254254 7578 89366607
Eating disorder 76.38 12.47 172 1254090 27901 89346284
Genital haemorrhage 76.31 12.47 14 1254248 8688 89365497
Hepatic necrosis 75.93 12.47 3 1254259 6435 89367750
Dry skin 75.91 12.47 815 1253447 87258 89286927
Ankle deformity 75.85 12.47 59 1254203 427 89373758
Incontinence 75.69 12.47 46 1254216 13389 89360796
Sickle cell anaemia with crisis 75.31 12.47 7 1254255 7290 89366895
Hypogammaglobulinaemia 74.84 12.47 27 1254235 10647 89363538
Aspergillus infection 74.84 12.47 28 1254234 10795 89363390
Urinary tract infection 74.77 12.47 3461 1250801 302171 89072014
Fistula 74.48 12.47 37 1254225 12052 89362133
Foetal growth restriction 74.31 12.47 19 1254243 9361 89364824
Immune system disorder 74.01 12.47 344 1253918 11561 89362624
Cholecystitis 73.78 12.47 76 1254186 16964 89357221
Renal disorder 73.66 12.47 272 1253990 37587 89336598
Ankle operation 73.21 12.47 97 1254165 1405 89372780
Bronchopulmonary aspergillosis 73.12 12.47 33 1254229 11365 89362820
Hypertriglyceridaemia 72.94 12.47 11 1254251 7878 89366307
Swelling face 72.89 12.47 746 1253516 80606 89293579
Concomitant disease aggravated 72.88 12.47 34 1254228 11484 89362701
Hip surgery 72.87 12.47 172 1254090 4023 89370162
Asphyxia 72.81 12.47 7 1254255 7096 89367089
Spinal pain 72.59 12.47 419 1253843 15348 89358837
Device breakage 72.50 12.47 53 1254209 13991 89360194
Atypical femur fracture 72.46 12.47 4 1254258 6417 89367768
Partial seizures 72.24 12.47 8 1254254 7252 89366933
Dysuria 72.20 12.47 290 1253972 39111 89335074
Pseudomonas infection 71.80 12.47 60 1254202 14805 89359380
Polyuria 71.07 12.47 25 1254237 10015 89364170
Dyspepsia 71.04 12.47 2143 1252119 196017 89178168
Respiratory syncytial virus infection 70.99 12.47 28 1254234 10452 89363733
Helicobacter infection 70.90 12.47 3829 1250433 223021 89151164
Pneumothorax 70.69 12.47 97 1254165 19070 89355115
Atrial septal defect 70.61 12.47 14 1254248 8220 89365965
Panic attack 70.55 12.47 163 1254099 26202 89347983
Kidney infection 70.53 12.47 606 1253656 25310 89348875
Hereditary angioedema 70.39 12.47 21 1254241 9344 89364841
Hypovolaemic shock 70.12 12.47 8 1254254 7086 89367099
Miosis 69.97 12.47 22 1254240 9462 89364723
Amylase increased 69.84 12.47 8 1254254 7064 89367121
Blood calcium increased 69.75 12.47 40 1254222 12018 89362167
Hypertensive crisis 69.71 12.47 86 1254176 17698 89356487
Product prescribing issue 69.62 12.47 13 1254249 7966 89366219
Muscle spasms 69.56 12.47 2814 1251448 249069 89125116
Rheumatoid factor increased 69.54 12.47 122 1254140 2289 89371896
Atrial flutter 69.25 12.47 31 1254231 10727 89363458
Urosepsis 69.11 12.47 117 1254145 21115 89353070
Uveitis 68.95 12.47 416 1253846 15487 89358698
Mental impairment 68.59 12.47 78 1254184 16642 89357543
Hyperlipidaemia 68.58 12.47 133 1254129 22783 89351402
Epilepsy 68.34 12.47 767 1253495 81439 89292746
Dissociation 67.83 12.47 7 1254255 6708 89367477
Atrioventricular block 67.67 12.47 19 1254243 8796 89365389
Forced expiratory volume decreased 67.52 12.47 3 1254259 5805 89368380
Peripheral sensory neuropathy 67.28 12.47 22 1254240 9228 89364957
Secretion discharge 67.14 12.47 413 1253849 15483 89358702
Incorrect product administration duration 67.11 12.47 102 1254160 19220 89354965
Hiatus hernia 66.89 12.47 158 1254104 25203 89348982
Dialysis 66.37 12.47 37 1254225 11292 89362893
Blood pressure diastolic increased 66.24 12.47 49 1254213 12857 89361328
Nasal oedema 66.16 12.47 7 1254255 6577 89367608
Breast cancer metastatic 66.07 12.47 67 1254195 15065 89359120
Rheumatoid factor negative 66.03 12.47 60 1254202 551 89373634
Feeling abnormal 65.96 12.47 2888 1251374 164347 89209838
Angina unstable 65.95 12.47 10 1254252 7133 89367052
Restless legs syndrome 65.88 12.47 132 1254130 22338 89351847
Potentiating drug interaction 65.57 12.47 3 1254259 5659 89368526
Catheter site infection 65.47 12.47 3 1254259 5651 89368534
Immune thrombocytopenia 65.35 12.47 53 1254209 13273 89360912
Lung opacity 65.32 12.47 5 1254257 6097 89368088
Liver function test increased 65.31 12.47 1587 1252675 83268 89290917
SLE arthritis 65.22 12.47 64 1254198 653 89373532
Drug-induced liver injury 64.75 12.47 870 1253392 89448 89284737
Disease recurrence 64.75 12.47 284 1253978 37369 89336816
Haemophagocytic lymphohistiocytosis 64.64 12.47 71 1254191 15388 89358797
Sleep disorder due to a general medical condition 64.52 12.47 359 1253903 44379 89329806
Major depression 64.46 12.47 29 1254233 10006 89364179
Decubitus ulcer 64.41 12.47 42 1254220 11771 89362414
Granulocytopenia 64.33 12.47 7 1254255 6434 89367751
Eye irritation 64.23 12.47 247 1254015 33731 89340454
Device occlusion 64.20 12.47 24 1254238 9258 89364927
Gait inability 64.08 12.47 2557 1251705 143899 89230286
Musculoskeletal deformity 64.01 12.47 103 1254159 1795 89372390
Diastolic dysfunction 63.87 12.47 12 1254250 7321 89366864
White blood cell count increased 63.84 12.47 608 1253654 66633 89307552
Skin toxicity 63.72 12.47 9 1254253 6770 89367415
Clonus 63.62 12.47 4 1254258 5746 89368439
Rhinovirus infection 63.51 12.47 5 1254257 5958 89368227
Blood triglycerides increased 63.50 12.47 58 1254204 13703 89360482
Injection site oedema 62.66 12.47 98 1254164 1665 89372520
Product substitution issue 62.61 12.47 95 1254167 17913 89356272
Nystagmus 62.58 12.47 12 1254250 7215 89366970
Animal bite 62.53 12.47 136 1254126 3007 89371178
Catatonia 61.99 12.47 6 1254256 6050 89368135
Sudden death 61.95 12.47 37 1254225 10872 89363313
Throat tightness 61.95 12.47 205 1254057 29279 89344906
Macule 61.90 12.47 123 1254139 2546 89371639
Thirst 61.59 12.47 81 1254181 16214 89357971
Ketoacidosis 61.58 12.47 4 1254258 5591 89368594
Disability 61.51 12.47 847 1253415 39898 89334287
Dermatitis bullous 61.44 12.47 33 1254229 10283 89363902
Unintended pregnancy 61.41 12.47 15 1254247 7622 89366563
Arteriosclerosis 61.37 12.47 37 1254225 10816 89363369
Bradyphrenia 61.11 12.47 15 1254247 7597 89366588
Left ventricular hypertrophy 60.55 12.47 7 1254255 6137 89368048
Exercise tolerance decreased 60.39 12.47 15 1254247 7536 89366649
Iron deficiency anaemia 60.37 12.47 150 1254112 23512 89350673
Surgical failure 60.15 12.47 71 1254191 908 89373277
Orthopnoea 59.93 12.47 11 1254251 6824 89367361
Hyperreflexia 59.93 12.47 10 1254252 6647 89367538
Electrocardiogram abnormal 59.80 12.47 34 1254228 10264 89363921
Arteriosclerosis coronary artery 59.76 12.47 29 1254233 9574 89364611
Intestinal ischaemia 59.73 12.47 24 1254238 8859 89365326
Pemphigoid 59.70 12.47 25 1254237 9001 89365184
Gastrointestinal disorder 59.65 12.47 4222 1250040 252465 89121720
Rib fracture 59.63 12.47 178 1254084 26257 89347928
Blood thyroid stimulating hormone increased 59.53 12.47 26 1254236 9129 89365056
Body height decreased 59.25 12.47 47 1254215 11902 89362283
Somnambulism 59.18 12.47 8 1254254 6220 89367965
Blood parathyroid hormone decreased 59.12 12.47 329 1253933 11887 89362298
Clostridium test positive 59.04 12.47 4 1254258 5397 89368788
Muscle twitching 59.00 12.47 157 1254105 24045 89350140
Drug level below therapeutic 58.89 12.47 6 1254256 5808 89368377
Panniculitis 58.79 12.47 372 1253890 14086 89360099
Meniscus injury 58.76 12.47 248 1254014 7989 89366196
Gallbladder operation 58.70 12.47 123 1254139 2648 89371537
Malignant melanoma 58.42 12.47 335 1253927 12241 89361944
Wheelchair user 58.37 12.47 238 1254024 7547 89366638
Ventricular hypokinesia 58.25 12.47 4 1254258 5337 89368848
Head injury 58.13 12.47 228 1254034 30960 89343225
Nocturia 57.93 12.47 35 1254227 10220 89363965
Blindness 57.72 12.47 182 1254080 26386 89347799
Hypoventilation 57.66 12.47 4 1254258 5292 89368893
Protein urine present 57.58 12.47 13 1254249 6971 89367214
Granuloma skin 57.37 12.47 296 1253966 10384 89363801
Inappropriate schedule of product administration 57.35 12.47 1607 1252655 148326 89225859
Lung infiltration 56.70 12.47 77 1254185 15205 89358980
Stress 56.66 12.47 1502 1252760 79893 89294292
Oral mucosal exfoliation 56.52 12.47 94 1254168 1686 89372499
Systemic lupus erythematosus rash 56.50 12.47 111 1254151 2278 89371907
Cyst 56.50 12.47 408 1253854 16153 89358032
Aplasia pure red cell 56.33 12.47 4 1254258 5190 89368995
Oligohydramnios 56.26 12.47 15 1254247 7186 89366999
Diverticulitis 56.00 12.47 908 1253354 44279 89329906
Cytomegalovirus infection reactivation 55.95 12.47 19 1254243 7781 89366404
Neck surgery 55.62 12.47 101 1254161 1949 89372236
Escherichia bacteraemia 55.38 12.47 7 1254255 5728 89368457
Proctalgia 55.37 12.47 22 1254240 8176 89366009
Pyelonephritis 55.27 12.47 134 1254128 21182 89353003
Product preparation error 55.25 12.47 37 1254225 10224 89363961
C-reactive protein increased 55.14 12.47 3054 1251208 178335 89195850
Tendon operation 54.97 12.47 42 1254220 295 89373890
Upper respiratory tract congestion 54.96 12.47 109 1254153 2253 89371932
Product availability issue 54.93 12.47 17 1254245 7387 89366798
Diverticulum intestinal 54.81 12.47 29 1254233 9113 89365072
Elbow operation 54.68 12.47 46 1254216 377 89373808
Serum ferritin increased 54.67 12.47 17 1254245 7364 89366821
Rheumatoid lung 54.45 12.47 152 1254110 3951 89370234
Product physical issue 54.43 12.47 7 1254255 5653 89368532
Hyperuricaemia 54.41 12.47 13 1254249 6706 89367479
Respiration abnormal 54.39 12.47 21 1254241 7942 89366243
Swelling of eyelid 54.29 12.47 6 1254256 5448 89368737
Blood phosphorus decreased 54.24 12.47 4 1254258 5030 89369155
Periorbital swelling 54.11 12.47 3 1254259 4795 89369390
Retching 54.09 12.47 115 1254147 19044 89355141
Bedridden 54.09 12.47 320 1253942 11828 89362357
Coma scale abnormal 54 12.47 7 1254255 5619 89368566
Venoocclusive liver disease 53.96 12.47 9 1254253 5984 89368201
Atrial tachycardia 53.92 12.47 9 1254253 5981 89368204
Odynophagia 53.75 12.47 29 1254233 9014 89365171
Initial insomnia 53.69 12.47 31 1254231 9279 89364906
Abnormal dreams 53.68 12.47 46 1254216 11211 89362974
Immune-mediated enterocolitis 53.57 12.47 3 1254259 4754 89369431
Bundle branch block left 53.52 12.47 21 1254241 7864 89366321
Gastroenteritis viral 53.40 12.47 649 1253613 29706 89344479
Pollakiuria 53.15 12.47 255 1254007 32750 89341435
Azotaemia 52.94 12.47 6 1254256 5342 89368843
Blood pressure inadequately controlled 52.50 12.47 11 1254251 6213 89367972
Intestinal perforation 52.46 12.47 69 1254193 13812 89360373
Hypoxic-ischaemic encephalopathy 52.40 12.47 3 1254259 4665 89369520
Guttate psoriasis 52.36 12.47 52 1254210 539 89373646
Pre-existing condition improved 52.21 12.47 31 1254231 9138 89365047
Metabolic disorder 52.20 12.47 19 1254243 7451 89366734
Ileus paralytic 52.15 12.47 5 1254257 5080 89369105
Tenosynovitis 52.10 12.47 363 1253899 14204 89359981
Systemic inflammatory response syndrome 52.00 12.47 13 1254249 6503 89367682
Brain injury 51.88 12.47 21 1254241 7717 89366468
Blood pressure systolic decreased 51.86 12.47 32 1254230 9238 89364947
Tongue oedema 51.84 12.47 7 1254255 5447 89368738
Bunion operation 51.80 12.47 78 1254184 1280 89372905
Supraventricular extrasystoles 51.79 12.47 6 1254256 5251 89368934
Pulmonary haemorrhage 51.72 12.47 23 1254239 7990 89366195
Duodenal ulcer perforation 51.62 12.47 3641 1250621 217647 89156538
Graft versus host disease 51.59 12.47 24 1254238 8120 89366065
Pulmonary fibrosis 51.55 12.47 1896 1252366 105607 89268578
Joint surgery 51.52 12.47 47 1254215 434 89373751
Candida infection 51.48 12.47 269 1253993 33788 89340397
Skin discolouration 51.43 12.47 881 1253381 43434 89330751
Endodontic procedure 51.41 12.47 134 1254128 3341 89370844
Iron deficiency 51.30 12.47 35 1254227 9577 89364608
Pathogen resistance 51.28 12.47 24 1254238 8091 89366094
Ventricular septal defect 51.25 12.47 7 1254255 5400 89368785
Induration 51.21 12.47 85 1254177 1522 89372663
Application site erythema 51.16 12.47 6 1254256 5202 89368983
Premature labour 51.06 12.47 66 1254196 13310 89360875
Hot flush 51.05 12.47 551 1253711 58937 89315248
Pneumonia bacterial 51.03 12.47 61 1254201 12729 89361456
Bone swelling 51.02 12.47 89 1254173 1662 89372523
Petechiae 51.00 12.47 87 1254175 15654 89358531
Systemic infection 50.87 12.47 4 1254258 4771 89369414
Cataract operation 50.72 12.47 194 1254068 5969 89368216
Drug effective for unapproved indication 50.68 12.47 23 1254239 7895 89366290
Spinal column injury 50.49 12.47 100 1254162 2065 89372120
Obsessive-compulsive disorder 50.23 12.47 3 1254259 4501 89369684
Nasal congestion 50.19 12.47 1511 1252751 81903 89292282
Ecchymosis 49.99 12.47 58 1254204 12265 89361920
Muscular weakness 49.97 12.47 2343 1251919 204323 89169862
Femoral neck fracture 49.80 12.47 41 1254221 10192 89363993
Periorbital oedema 49.75 12.47 16 1254246 6783 89367402
Depressive symptom 49.72 12.47 7 1254255 5278 89368907
Endophthalmitis 49.70 12.47 4 1254258 4681 89369504
Aortic arteriosclerosis 49.68 12.47 22 1254240 7662 89366523
Pharyngeal swelling 49.45 12.47 39 1254223 9905 89364280
Diarrhoea haemorrhagic 49.13 12.47 45 1254217 10618 89363567
Musculoskeletal discomfort 49.07 12.47 475 1253787 20516 89353669
Amenorrhoea 48.83 12.47 54 1254208 11668 89362517
Enthesopathy 48.70 12.47 258 1254004 9146 89365039
Venous thrombosis 48.36 12.47 9 1254253 5528 89368657
Peritonitis bacterial 48.29 12.47 7 1254255 5164 89369021
Back pain 48.24 12.47 5055 1249207 312120 89062065
Blood creatine increased 48.21 12.47 18 1254244 6949 89367236
Wrong product administered 47.92 12.47 23 1254239 7642 89366543
Cholecystitis acute 47.89 12.47 36 1254226 9368 89364817
Ventricular arrhythmia 47.83 12.47 3 1254259 4318 89369867
Blood chloride decreased 47.81 12.47 14 1254248 6305 89367880
Polycystic ovaries 47.68 12.47 10 1254252 5644 89368541
Tumour marker increased 47.49 12.47 11 1254251 5796 89368389
Cerebral ischaemia 47.49 12.47 20 1254242 7176 89367009
Abortion spontaneous 47.48 12.47 498 1253764 53558 89320627
Bundle branch block right 47.33 12.47 9 1254253 5444 89368741
Escherichia urinary tract infection 46.96 12.47 74 1254188 13741 89360444
Thrombocytosis 46.94 12.47 19 1254243 6982 89367203
Synovial cyst 46.93 12.47 301 1253961 11451 89362734
Embedded device 46.87 12.47 3 1254259 4245 89369940
Carpal tunnel decompression 46.83 12.47 66 1254196 1017 89373168
Body height below normal 46.82 12.47 97 1254165 2071 89372114
Thyroid neoplasm 46.67 12.47 142 1254120 3879 89370306
Low turnover osteopathy 46.47 12.47 3 1254259 4215 89369970
Lymphoma 46.46 12.47 335 1253927 13256 89360929
Intracranial pressure increased 46.46 12.47 18 1254244 6793 89367392
Lip oedema 46.44 12.47 5 1254257 4634 89369551
Eye movement disorder 46.40 12.47 14 1254248 6184 89368001
Haemorrhagic stroke 46.29 12.47 16 1254246 6480 89367705
Sexual dysfunction 46.06 12.47 6 1254256 4798 89369387
Human antichimeric antibody positive 45.95 12.47 86 1254176 1700 89372485
Pre-eclampsia 45.91 12.47 51 1254211 10997 89363188
Sensitisation 45.91 12.47 3 1254259 4172 89370013
Dyspnoea at rest 45.89 12.47 6 1254256 4785 89369400
Duodenal ulcer 45.59 12.47 39 1254223 9513 89364672
Cachexia 45.57 12.47 19 1254243 6859 89367326
Latent tuberculosis 45.30 12.47 116 1254146 2860 89371325
Faeces soft 44.77 12.47 24 1254238 7487 89366698
Pseudomonal sepsis 44.74 12.47 4 1254258 4298 89369887
Euphoric mood 44.73 12.47 10 1254252 5399 89368786
Tachyarrhythmia 44.69 12.47 10 1254252 5396 89368789
Spinal fusion surgery 44.47 12.47 307 1253955 11976 89362209
Product administration error 44.40 12.47 201 1254061 26222 89347963
Post procedural haemorrhage 44.39 12.47 34 1254228 8764 89365421
Cardiovascular disorder 44.24 12.47 74 1254188 13418 89360767
Skin mass 44.22 12.47 212 1254050 7218 89366967
Brain natriuretic peptide increased 44.17 12.47 14 1254248 5991 89368194
Stillbirth 44.05 12.47 24 1254238 7419 89366766
Cystitis haemorrhagic 44.00 12.47 11 1254251 5502 89368683
Device power source issue 43.98 12.47 57 1254205 807 89373378
Eye operation 43.76 12.47 108 1254154 2601 89371584
Joint laxity 43.76 12.47 106 1254156 2522 89371663
Blood immunoglobulin E increased 43.72 12.47 5 1254257 4420 89369765
Stridor 43.59 12.47 7 1254255 4786 89369399
Renal cyst 43.42 12.47 70 1254192 12880 89361305
Respiratory rate decreased 43.39 12.47 3 1254259 3980 89370205
Oxygen consumption increased 43.36 12.47 6 1254256 4583 89369602
Neutrophilia 43.35 12.47 13 1254249 5765 89368420
Post transplant lymphoproliferative disorder 43.22 12.47 21 1254241 6928 89367257
Infection susceptibility increased 43.12 12.47 136 1254126 3790 89370395
Device dispensing error 43.11 12.47 29 1254233 162 89374023
Intervertebral disc protrusion 42.97 12.47 570 1253692 26626 89347559
Blood thyroid stimulating hormone decreased 42.91 12.47 13 1254249 5727 89368458
Central nervous system lesion 42.89 12.47 59 1254203 11587 89362598
Drooling 42.82 12.47 6 1254256 4540 89369645
Personality change 42.76 12.47 24 1254238 7297 89366888
Escherichia infection 42.75 12.47 98 1254164 15797 89358388
International normalised ratio decreased 42.74 12.47 7 1254255 4717 89369468
Dyslipidaemia 42.72 12.47 46 1254216 10061 89364124
Blood culture positive 42.71 12.47 9 1254253 5063 89369122
Tooth abscess 42.69 12.47 380 1253882 16033 89358152
Gastritis erosive 42.65 12.47 20 1254242 6735 89367450
Obstruction 42.58 12.47 3 1254259 3918 89370267
Exposure to toxic agent 42.53 12.47 29 1254233 7938 89366247
Embolism 42.52 12.47 41 1254221 9440 89364745
Blood phosphorus increased 42.36 12.47 5 1254257 4313 89369872
Ankylosing spondylitis 42.21 12.47 319 1253943 12814 89361371
Injection site hypoaesthesia 42.14 12.47 49 1254213 616 89373569
Injection site coldness 41.97 12.47 23 1254239 82 89374103
Tension headache 41.90 12.47 26 1254236 7483 89366702
Vulvovaginal mycotic infection 41.90 12.47 186 1254076 6128 89368057
Red cell distribution width increased 41.86 12.47 65 1254197 12142 89362043
Pelvic pain 41.85 12.47 94 1254168 15263 89358922
Basal cell carcinoma 41.77 12.47 672 1253590 32717 89341468
Fatigue 41.74 12.47 17132 1237130 1136891 88237294
Contrast media allergy 41.74 12.47 115 1254147 2966 89371219
Behaviour disorder 41.64 12.47 7 1254255 4628 89369557
Purpura 41.48 12.47 89 1254173 14689 89359496
Ischaemia 41.42 12.47 11 1254251 5284 89368901
Culture urine positive 41.33 12.47 3 1254259 3822 89370363
Hypoaesthesia oral 41.29 12.47 97 1254165 15503 89358682
Metastases to lymph nodes 41.28 12.47 61 1254201 11628 89362557
Local reaction 41.28 12.47 53 1254209 743 89373442
Polydipsia 41.25 12.47 5 1254257 4226 89369959
Pneumonia fungal 41.13 12.47 23 1254239 7008 89367177
Pruritus allergic 41.08 12.47 81 1254181 1667 89372518
Hyperpyrexia 41.02 12.47 8 1254254 4753 89369432
Weight fluctuation 41.02 12.47 138 1254124 19611 89354574
Patent ductus arteriosus 40.83 12.47 7 1254255 4562 89369623
Cough 40.82 12.47 5764 1248498 363198 89010987
Device deployment issue 40.75 12.47 9 1254253 4900 89369285
Disturbance in social behaviour 40.71 12.47 5 1254257 4183 89370002
Sensory disturbance 40.67 12.47 96 1254166 15317 89358868
Psychiatric symptom 40.62 12.47 24 1254238 7094 89367091
Polyarthritis 40.35 12.47 410 1253852 17940 89356245
Protein total decreased 40.32 12.47 24 1254238 7065 89367120
Red blood cell sedimentation rate 40.30 12.47 149 1254113 4509 89369676
Portal hypertension 40.29 12.47 8 1254254 4693 89369492
Therapeutic response shortened 40.29 12.47 171 1254091 22708 89351477
Lymphoedema 40.14 12.47 81 1254181 13672 89360513
Dermatitis allergic 39.97 12.47 391 1253871 16936 89357249
Disability assessment scale score increased 39.96 12.47 4 1254258 3927 89370258
Lung consolidation 39.92 12.47 9 1254253 4831 89369354
Cardiac tamponade 39.91 12.47 14 1254248 5618 89368567
Injection site anaesthesia 39.84 12.47 17 1254245 28 89374157
Aortic valve incompetence 39.73 12.47 21 1254241 6603 89367582
Ammonia increased 39.69 12.47 10 1254252 4976 89369209
Lung transplant 39.59 12.47 3 1254259 3689 89370496
Electrocardiogram T wave inversion 39.47 12.47 3 1254259 3680 89370505
Petit mal epilepsy 39.36 12.47 10 1254252 4948 89369237
Eyelid ptosis 39.18 12.47 40 1254222 8966 89365219
Pustular psoriasis 39.10 12.47 411 1253851 18145 89356040
Scar excision 38.99 12.47 20 1254242 60 89374125
Spinal compression fracture 38.89 12.47 96 1254166 15082 89359103
Blood prolactin increased 38.88 12.47 3 1254259 3634 89370551
Rash papular 38.81 12.47 442 1253820 19913 89354272
Splenomegaly 38.68 12.47 75 1254187 12849 89361336
Glycosylated haemoglobin increased 38.66 12.47 100 1254162 15462 89358723
Exposure via skin contact 38.66 12.47 55 1254207 10650 89363535
Gastric ulcer 38.63 12.47 222 1254040 27226 89346959
Sneezing 38.44 12.47 604 1253658 29265 89344920
Cerebral atrophy 38.38 12.47 15 1254247 5631 89368554
Skin reaction 38.19 12.47 409 1253853 18144 89356041
Faecal calprotectin increased 38.17 12.47 5 1254257 3982 89370203
Laryngeal oedema 38.15 12.47 24 1254238 6857 89367328
Mass excision 37.97 12.47 35 1254227 328 89373857
Maternal drugs affecting foetus 37.95 12.47 12 1254250 5143 89369042
Fluid intake reduced 37.91 12.47 6 1254256 4146 89370039
Reversible cerebral vasoconstriction syndrome 37.63 12.47 6 1254256 4124 89370061
Mucous stools 37.53 12.47 13 1254249 5258 89368927
Flank pain 37.46 12.47 138 1254124 19084 89355101
Diffuse large B-cell lymphoma recurrent 37.43 12.47 3 1254259 3523 89370662
Pulmonary arterial pressure increased 37.28 12.47 5 1254257 3911 89370274
Movement disorder 37.04 12.47 242 1254020 28777 89345408
Hypopnoea 37.03 12.47 8 1254254 4423 89369762
Hydrocephalus 37.02 12.47 19 1254243 6075 89368110
Peripheral ischaemia 37.00 12.47 16 1254246 5651 89368534
Vitamin D deficiency 36.93 12.47 122 1254140 17434 89356751
Neurogenic bladder 36.73 12.47 4 1254258 3674 89370511
Aortic stenosis 36.68 12.47 21 1254241 6315 89367870
Application site pain 36.56 12.47 10 1254252 4710 89369475
Scleritis 36.53 12.47 156 1254106 5052 89369133
Long QT syndrome 36.48 12.47 6 1254256 4031 89370154
Rash morbilliform 36.39 12.47 6 1254256 4023 89370162
Haemoglobin increased 36.38 12.47 30 1254232 7451 89366734
Staphylococcal bacteraemia 36.26 12.47 30 1254232 7439 89366746
Sinus disorder 36.14 12.47 674 1253588 33773 89340412
Abnormal faeces 36.11 12.47 24 1254238 6658 89367527
Mucormycosis 36.09 12.47 5 1254257 3816 89370369
Drug effect less than expected 36.02 12.47 20 1254242 6118 89368067
Embolism venous 35.99 12.47 4 1254258 3616 89370569
Cholangitis 35.93 12.47 28 1254234 7154 89367031
Exposure to communicable disease 35.79 12.47 45 1254217 617 89373568
Sinus node dysfunction 35.78 12.47 15 1254247 5397 89368788
Intermenstrual bleeding 35.73 12.47 45 1254217 9178 89365007
Cardiac dysfunction 35.70 12.47 4 1254258 3593 89370592
Neoplasm malignant 35.23 12.47 662 1253600 33218 89340967
Performance status decreased 35.22 12.47 8 1254254 4272 89369913
Intentional dose omission 35.20 12.47 389 1253873 17394 89356791
Abdominal wall haematoma 35.18 12.47 3 1254259 3349 89370836
Blood glucose decreased 34.88 12.47 186 1254076 23243 89350942
Skin exfoliation 34.83 12.47 696 1253566 67217 89306968
Embolic stroke 34.76 12.47 7 1254255 4065 89370120
Increased appetite 34.59 12.47 69 1254193 11696 89362489
Aphthous ulcer 34.42 12.47 123 1254139 17164 89357021
Immune reconstitution inflammatory syndrome 34.31 12.47 28 1254234 6991 89367194
Scratch 34.20 12.47 244 1254018 9622 89364563
Immobile 34.14 12.47 177 1254085 6221 89367964
International normalised ratio abnormal 34.12 12.47 6 1254256 3839 89370346
Maternal exposure during breast feeding 34.07 12.47 22 1254240 6198 89367987
Necrosis 34.05 12.47 25 1254237 6585 89367600
Endocarditis 34 12.47 29 1254233 7084 89367101
Large intestine perforation 33.99 12.47 51 1254211 9661 89364524
Neoplasm recurrence 33.97 12.47 3 1254259 3256 89370929
Pulmonary function test decreased 33.92 12.47 10 1254252 4484 89369701
Skin hyperpigmentation 33.90 12.47 27 1254235 6824 89367361
Haemoglobin abnormal 33.87 12.47 29 1254233 7071 89367114
Incorrect dose administered 33.86 12.47 832 1253430 78098 89296087
Occupational exposure to product 33.82 12.47 94 1254168 2437 89371748
Coronavirus infection 33.80 12.47 17 1254245 5498 89368687
Cardiac failure chronic 33.71 12.47 18 1254244 5628 89368557
Nerve injury 33.60 12.47 266 1253996 10840 89363345
Sensitivity to weather change 33.58 12.47 225 1254037 8689 89365496
Toe operation 33.55 12.47 59 1254203 1109 89373076
Inadequate analgesia 33.52 12.47 3 1254259 3221 89370964
Bronchiectasis 33.40 12.47 177 1254085 22153 89352032
Acute graft versus host disease in skin 33.40 12.47 12 1254250 4744 89369441
Anosmia 33.24 12.47 53 1254209 9795 89364390
Hepatitis fulminant 33.22 12.47 7 1254255 3938 89370247
Colonoscopy 33.16 12.47 74 1254188 1666 89372519
Dental care 33.11 12.47 62 1254200 1226 89372959
Hypokinesia 33.07 12.47 109 1254153 15588 89358597
Skin papilloma 33.04 12.47 160 1254102 5470 89368715
Epidural injection 32.94 12.47 10 1254252 0 89374185
Ventricular dysfunction 32.72 12.47 6 1254256 3725 89370460
Non-cardiac chest pain 32.62 12.47 27 1254235 6694 89367491
Incoherent 32.58 12.47 14 1254248 4963 89369222
Dermatitis exfoliative 32.55 12.47 18 1254244 5518 89368667
Oesophageal pain 32.53 12.47 10 1254252 4364 89369821
Muscle haemorrhage 32.51 12.47 4 1254258 3342 89370843
Hypoproteinaemia 32.46 12.47 3 1254259 3139 89371046
Galactorrhoea 32.45 12.47 12 1254250 4660 89369525
Haemoperitoneum 32.43 12.47 5 1254257 3523 89370662
Cerebellar syndrome 32.34 12.47 7 1254255 3865 89370320
Intervertebral disc operation 32.34 12.47 51 1254211 873 89373312
Ovarian neoplasm 32.30 12.47 51 1254211 874 89373311
Weight increased 32.28 12.47 5185 1249077 412742 88961443
Lymphocyte percentage decreased 32.27 12.47 3 1254259 3124 89371061
Gout 32.22 12.47 122 1254140 16737 89357448
Stress at work 32.20 12.47 64 1254198 1325 89372860
Staphylococcus test positive 32.19 12.47 10 1254252 4335 89369850
Occult blood positive 32.16 12.47 8 1254254 4015 89370170
Feeling cold 32.11 12.47 235 1254027 27230 89346955
Gastrointestinal perforation 32.04 12.47 10 1254252 4322 89369863
Tonsillar ulcer 31.98 12.47 30 1254232 288 89373897
Electrocardiogram ST segment depression 31.97 12.47 4 1254258 3299 89370886
Neonatal respiratory distress syndrome 31.94 12.47 3 1254259 3098 89371087
Epstein-Barr virus infection 31.86 12.47 59 1254203 10285 89363900
Oropharyngeal discomfort 31.82 12.47 36 1254226 7699 89366486
Low density lipoprotein increased 31.79 12.47 39 1254223 8046 89366139
Juvenile idiopathic arthritis 31.76 12.47 124 1254138 3853 89370332
Post procedural infection 31.75 12.47 262 1254000 10812 89363373
Dental operation 31.65 12.47 70 1254192 1566 89372619
Injection site cellulitis 31.62 12.47 67 1254195 1454 89372731
Thrombotic thrombocytopenic purpura 31.62 12.47 9 1254253 4129 89370056
Congestive cardiomyopathy 31.61 12.47 33 1254229 7321 89366864
Diverticulum 31.52 12.47 76 1254186 12037 89362148
Total lung capacity decreased 31.42 12.47 7 1254255 3788 89370397
Small for dates baby 31.34 12.47 15 1254247 4992 89369193
Fibrosis 31.33 12.47 22 1254240 5930 89368255
Anaemia macrocytic 31.33 12.47 12 1254250 4560 89369625
SARS-CoV-2 test positive 31.25 12.47 67 1254195 11061 89363124
Spider vein 31.25 12.47 33 1254229 370 89373815
Carpal tunnel syndrome 31.22 12.47 485 1253777 23443 89350742
Pruritus genital 31.17 12.47 12 1254250 4546 89369639
Hepatic lesion 31.16 12.47 20 1254242 5653 89368532
Skin laceration 31.09 12.47 520 1253742 25515 89348670
Bone lesion 31.07 12.47 26 1254236 6411 89367774
Congestive hepatopathy 31.06 12.47 3 1254259 3030 89371155
Ankle arthroplasty 31.03 12.47 98 1254164 2733 89371452
Cytomegalovirus test positive 31.01 12.47 6 1254256 3585 89370600
Rotator cuff syndrome 30.95 12.47 347 1253915 15572 89358613
Thrombophlebitis 30.94 12.47 14 1254248 4814 89369371
Self-medication 30.92 12.47 4 1254258 3216 89370969
Cold sweat 30.91 12.47 96 1254166 13985 89360200
Platelet count increased 30.83 12.47 166 1254096 20693 89353492
Retinal haemorrhage 30.75 12.47 21 1254241 5743 89368442
Pathological fracture 30.74 12.47 54 1254208 9606 89364579
Glaucoma 30.74 12.47 430 1253832 20325 89353860
Self-injurious ideation 30.71 12.47 4 1254258 3199 89370986
Abdominal tenderness 30.70 12.47 51 1254211 9273 89364912
Neutrophil percentage increased 30.68 12.47 3 1254259 3000 89371185
Decreased activity 30.67 12.47 41 1254221 8151 89366034
Duodenitis 30.65 12.47 11 1254251 4352 89369833
Loose body in joint 30.60 12.47 63 1254199 1339 89372846
Hypoglycaemic coma 30.51 12.47 3 1254259 2987 89371198
Exostosis 30.50 12.47 957 1253305 52177 89322008
Drug tolerance decreased 30.43 12.47 619 1253643 31511 89342674
Growth failure 30.42 12.47 32 1254230 357 89373828
Defaecation urgency 30.39 12.47 25 1254237 6217 89367968
Blood immunoglobulin G decreased 30.37 12.47 6 1254256 3532 89370653
Hyperventilation 30.29 12.47 29 1254233 6699 89367486
Accident 30.21 12.47 182 1254080 6772 89367413
Phlebitis 30.11 12.47 35 1254227 7395 89366790
Walking aid user 30.07 12.47 673 1253589 34833 89339352
Mean cell volume increased 29.99 12.47 16 1254246 5005 89369180
Focal dyscognitive seizures 29.97 12.47 4 1254258 3140 89371045
Compression fracture 29.95 12.47 47 1254215 8742 89365443
Haemarthrosis 29.94 12.47 9 1254253 3985 89370200
Bone graft 29.92 12.47 52 1254210 968 89373217
Injection site pustule 29.83 12.47 20 1254242 111 89374074
Anger 29.79 12.47 94 1254168 13626 89360559
Bilirubin conjugated increased 29.79 12.47 4 1254258 3126 89371059
Areflexia 29.72 12.47 7 1254255 3646 89370539
Neutrophil count abnormal 29.70 12.47 10 1254252 4118 89370067
Eye infection 29.70 12.47 315 1253947 13939 89360246
Extrasystoles 29.66 12.47 21 1254241 5636 89368549
Breath sounds abnormal 29.63 12.47 111 1254151 15275 89358910
Anal fissure 29.56 12.47 19 1254243 5366 89368819
Progressive multifocal leukoencephalopathy 29.46 12.47 114 1254148 15541 89358644
Amnesia 29.32 12.47 1215 1253047 107290 89266895
Knee deformity 29.28 12.47 66 1254196 1496 89372689
Communication disorder 29.19 12.47 5 1254257 3261 89370924
Affective disorder 29.18 12.47 39 1254223 7754 89366431
Tooth extraction 29.15 12.47 265 1253997 11248 89362937
Mass 29.14 12.47 337 1253925 15240 89358945
Taste disorder 29.13 12.47 639 1253623 60907 89313278
Drug screen positive 29.02 12.47 8 1254254 3749 89370436
Fibrin D dimer increased 28.98 12.47 20 1254242 5440 89368745
Cross sensitivity reaction 28.80 12.47 3 1254259 2854 89371331
Macular oedema 28.80 12.47 16 1254246 4893 89369292
Malabsorption 28.79 12.47 18 1254244 5160 89369025
Wound dehiscence 28.74 12.47 23 1254239 5799 89368386
Spinal stenosis 28.70 12.47 368 1253894 17056 89357129
Pyelonephritis acute 28.70 12.47 20 1254242 5412 89368773
Sleep terror 28.52 12.47 13 1254249 4451 89369734
Blood chloride increased 28.50 12.47 5 1254257 3205 89370980
Pseudomembranous colitis 28.49 12.47 9 1254253 3859 89370326
Persecutory delusion 28.48 12.47 5 1254257 3203 89370982
Appendicitis 28.40 12.47 62 1254200 10169 89364016
Intentional product use issue 28.37 12.47 2599 1251663 214293 89159892
Sinus pain 28.26 12.47 20 1254242 5369 89368816
Conjunctival haemorrhage 28.07 12.47 10 1254252 3974 89370211
Ocular icterus 28.02 12.47 10 1254252 3970 89370215
Hysterectomy 28.00 12.47 264 1253998 11320 89362865
Arthropod sting 27.98 12.47 58 1254204 1239 89372946
Neurological decompensation 27.91 12.47 7 1254255 3494 89370691
Abdominal pain upper 27.84 12.47 4108 1250154 328566 89045619
Acute graft versus host disease 27.76 12.47 21 1254241 5447 89368738
Malignant pleural effusion 27.71 12.47 4 1254258 2960 89371225
Extravasation 27.71 12.47 4 1254258 2960 89371225
Nail disorder 27.64 12.47 1039 1253223 58028 89316157
Insomnia 27.55 12.47 4121 1250141 329353 89044832
Arteriospasm coronary 27.47 12.47 18 1254244 5032 89369153
Escherichia sepsis 27.45 12.47 24 1254238 5792 89368393
Chronic respiratory failure 27.32 12.47 3 1254259 2738 89371447
Autonomic nervous system imbalance 27.31 12.47 7 1254255 3443 89370742
Pneumonia cytomegaloviral 27.29 12.47 5 1254257 3106 89371079
Maternal exposure before pregnancy 27.13 12.47 73 1254189 11140 89363045
Paronychia 27.10 12.47 43 1254219 7963 89366222
Colorectal cancer 27.04 12.47 10 1254252 3883 89370302
White blood cells urine positive 27.00 12.47 30 1254232 6468 89367717
Eructation 26.98 12.47 70 1254192 10812 89363373
Bone disorder 26.96 12.47 460 1253802 22660 89351525
Prescription drug used without a prescription 26.95 12.47 6 1254256 3249 89370936
Rotator cuff repair 26.94 12.47 85 1254177 2369 89371816
Orthosis user 26.94 12.47 19 1254243 116 89374069
Enuresis 26.88 12.47 7 1254255 3407 89370778
Generalised oedema 26.87 12.47 154 1254108 18899 89355286
Injection site scar 26.87 12.47 56 1254206 1201 89372984
Pneumonia klebsiella 26.81 12.47 5 1254257 3067 89371118
Epicondylitis 26.80 12.47 88 1254174 2506 89371679
Anal fistula 26.75 12.47 13 1254249 4288 89369897
Type I hypersensitivity 26.70 12.47 12 1254250 4143 89370042
Drug abuser 26.67 12.47 3 1254259 2687 89371498
Urine analysis abnormal 26.57 12.47 20 1254242 5201 89368984
Pulmonary thrombosis 26.56 12.47 60 1254202 9722 89364463
Ulcer 26.52 12.47 619 1253643 32263 89341922
Burn infection 26.48 12.47 15 1254247 58 89374127
Choking 26.44 12.47 82 1254180 11951 89362234
Gastrointestinal sounds abnormal 26.38 12.47 15 1254247 4528 89369657
Meningitis aseptic 26.29 12.47 33 1254229 6740 89367445
Peripheral coldness 26.25 12.47 101 1254161 13791 89360394
Physical disability 26.21 12.47 117 1254145 3864 89370321
Injection site dryness 26.19 12.47 40 1254222 665 89373520
Device related sepsis 26.19 12.47 17 1254245 4776 89369409
Mesenteritis 26.17 12.47 28 1254234 319 89373866
Spinal cord compression 26.05 12.47 18 1254244 4893 89369292
Mammoplasty 25.95 12.47 41 1254221 703 89373482
Vitreous haemorrhage 25.86 12.47 3 1254259 2623 89371562
Autoimmune haemolytic anaemia 25.80 12.47 24 1254238 5621 89368564
Urine abnormality 25.77 12.47 42 1254220 7695 89366490
Hypertonic bladder 25.76 12.47 14 1254248 4334 89369851
Coronary artery stenosis 25.75 12.47 21 1254241 5245 89368940
Osteoporosis 25.65 12.47 1606 1252656 94925 89279260
Arthritis infective 25.61 12.47 194 1254068 7798 89366387
Plasmacytoma 25.58 12.47 4 1254258 2789 89371396
Biliary dyskinesia 25.52 12.47 3 1254259 2596 89371589
Eosinophilic pneumonia 25.33 12.47 4 1254258 2769 89371416
Tetany 25.33 12.47 3 1254259 2581 89371604
Metastases to peritoneum 25.18 12.47 13 1254249 4142 89370043
Hepatitis toxic 25.15 12.47 10 1254252 3715 89370470
Injection site exfoliation 25.08 12.47 34 1254228 504 89373681
Haemorrhoidal haemorrhage 25.08 12.47 22 1254240 5301 89368884
Exposed bone in jaw 25.04 12.47 5 1254257 2921 89371264
Prosthesis user 25.03 12.47 15 1254247 66 89374119
Red cell distribution width decreased 24.97 12.47 77 1254185 2119 89372066
Urine ketone body present 24.92 12.47 3 1254259 2549 89371636
Pulmonary function test abnormal 24.91 12.47 4 1254258 2735 89371450
Reaction to preservatives 24.91 12.47 23 1254239 216 89373969
Injection site infection 24.90 12.47 80 1254182 2252 89371933
Nail pitting 24.88 12.47 27 1254235 313 89373872
Faeces hard 24.86 12.47 7 1254255 3235 89370950
Anxiety disorder 24.86 12.47 19 1254243 4903 89369282
Parosmia 24.86 12.47 37 1254225 7032 89367153
Acute psychosis 24.84 12.47 6 1254256 3072 89371113
Ventricular hypertrophy 24.78 12.47 8 1254254 3383 89370802
Metastasis 24.77 12.47 29 1254233 6108 89368077
Visual field defect 24.72 12.47 38 1254224 7128 89367057
Injection site erosion 24.69 12.47 16 1254246 83 89374102
Paradoxical drug reaction 24.64 12.47 26 1254236 5740 89368445
Streptococcal infection 24.64 12.47 180 1254082 7153 89367032
Pulmonary alveolar haemorrhage 24.58 12.47 28 1254234 5970 89368215
Cell death 24.57 12.47 6 1254256 3049 89371136
Bruxism 24.49 12.47 15 1254247 4348 89369837
Rash erythematous 24.49 12.47 1119 1253143 63985 89310200
Hypoaesthesia 24.46 12.47 4817 1249445 309393 89064792
Diabetic retinopathy 24.45 12.47 4 1254258 2698 89371487
Coronary artery occlusion 24.44 12.47 51 1254211 8503 89365682
Synovectomy 24.38 12.47 22 1254240 200 89373985
Dental implantation 24.37 12.47 44 1254218 845 89373340
Cyst removal 24.36 12.47 34 1254228 519 89373666
Heavy menstrual bleeding 24.32 12.47 175 1254087 20355 89353830
Inflammatory marker increased 24.31 12.47 214 1254048 9000 89365185
Dyschezia 24.30 12.47 5 1254257 2860 89371325
Polymyalgia rheumatica 24.15 12.47 20 1254242 4957 89369228
Laryngospasm 24.11 12.47 8 1254254 3325 89370860
Cardiopulmonary failure 24.07 12.47 14 1254248 4174 89370011
Bicytopenia 24.06 12.47 11 1254251 3760 89370425
Lower respiratory tract infection viral 24.01 12.47 46 1254216 926 89373259
Mean cell haemoglobin increased 23.99 12.47 12 1254250 3893 89370292
Intraventricular haemorrhage 23.87 12.47 3 1254259 2466 89371719
High density lipoprotein decreased 23.83 12.47 4 1254258 2647 89371538
Urticaria 23.80 12.47 4789 1249473 307945 89066240
Antibody test positive 23.71 12.47 93 1254169 2896 89371289
Menopause 23.70 12.47 100 1254162 3221 89370964
Micturition urgency 23.67 12.47 78 1254184 11155 89363030
Left ventricular failure 23.63 12.47 35 1254227 6665 89367520
Blood parathyroid hormone increased 23.58 12.47 9 1254253 3428 89370757
Rhinitis 23.56 12.47 102 1254160 13470 89360715
Wrist deformity 23.50 12.47 98 1254164 3140 89371045
Cutaneous T-cell lymphoma 23.49 12.47 62 1254200 1558 89372627
Hepatotoxicity 23.45 12.47 470 1253792 45372 89328813
Ischaemic cardiomyopathy 23.36 12.47 4 1254258 2609 89371576
Social avoidant behaviour 23.31 12.47 9 1254253 3404 89370781
Paralysis 23.30 12.47 81 1254181 11397 89362788
Staphylococcal infection 23.14 12.47 854 1253408 47585 89326600
Amyotrophic lateral sclerosis 23.12 12.47 55 1254207 1293 89372892
Neuralgia 23.09 12.47 302 1253960 31198 89342987
Monocyte count decreased 23.09 12.47 4 1254258 2587 89371598
Ligament rupture 23.08 12.47 108 1254154 3640 89370545
Renal function test abnormal 23.06 12.47 40 1254222 7151 89367034
Tendonitis 23.05 12.47 420 1253842 20952 89353233
Dermatitis exfoliative generalised 23.04 12.47 26 1254236 5567 89368618
Cytomegalovirus colitis 23.01 12.47 9 1254253 3377 89370808
Lacunar infarction 22.91 12.47 9 1254253 3368 89370817
Dysphoria 22.84 12.47 31 1254231 6123 89368062
Lactose intolerance 22.82 12.47 9 1254253 3360 89370825
Tenoplasty 22.76 12.47 20 1254242 175 89374010
Type IV hypersensitivity reaction 22.74 12.47 13 1254249 3913 89370272
Night sweats 22.74 12.47 2074 1252188 126692 89247493
Eosinophil count decreased 22.73 12.47 8 1254254 3204 89370981
Duodenal ulcer haemorrhage 22.66 12.47 4 1254258 2552 89371633
Oral pain 22.64 12.47 317 1253945 32366 89341819
Right ventricular dysfunction 22.55 12.47 3 1254259 2361 89371824
Bacterial test positive 22.55 12.47 26 1254236 5513 89368672
Mean cell haemoglobin concentration decreased 22.48 12.47 17 1254245 4411 89369774
Nephrotic syndrome 22.48 12.47 42 1254220 7297 89366888
Vulvovaginal candidiasis 22.47 12.47 13 1254249 3887 89370298
Injection site plaque 22.28 12.47 19 1254243 159 89374026
Decreased interest 22.27 12.47 17 1254245 4390 89369795
Normal newborn 22.27 12.47 211 1254051 23151 89351034
Laryngeal disorder 22.22 12.47 49 1254213 1094 89373091
Product administered to patient of inappropriate age 22.21 12.47 19 1254243 4634 89369551
Chronic graft versus host disease 22.18 12.47 15 1254247 4124 89370061
Bipolar disorder 22.12 12.47 58 1254204 8927 89365258
Oral surgery 22.05 12.47 60 1254202 1536 89372649
Clostridial infection 22.04 12.47 19 1254243 4617 89369568
Hypersomnia 22.04 12.47 191 1254071 21340 89352845
Herpes simplex 21.93 12.47 70 1254192 10111 89364074
Product label confusion 21.90 12.47 441 1253821 22409 89351776
Ejection fraction abnormal 21.86 12.47 4 1254258 2487 89371698
Intra-abdominal haemorrhage 21.86 12.47 5 1254257 2657 89371528
Incorrect drug administration rate 21.82 12.47 24 1254238 5199 89368986
Scab 21.76 12.47 218 1254044 9503 89364682
Procedural haemorrhage 21.74 12.47 8 1254254 3116 89371069
Eyelid oedema 21.70 12.47 84 1254178 11450 89362735
Laryngitis 21.69 12.47 884 1253378 49869 89324316
Haemolytic uraemic syndrome 21.69 12.47 6 1254256 2805 89371380
Fracture 21.64 12.47 198 1254064 21878 89352307
Hyperaemia 21.62 12.47 5 1254257 2637 89371548
Hypersensitivity pneumonitis 21.58 12.47 14 1254248 3934 89370251
Sputum increased 21.56 12.47 7 1254255 2950 89371235
Hepatic cyst 21.56 12.47 36 1254226 6532 89367653
Skin injury 21.52 12.47 73 1254189 2115 89372070
Product use complaint 21.49 12.47 11 1254251 3522 89370663
Hangnail 21.44 12.47 11 1254251 33 89374152
Linear IgA disease 21.42 12.47 3 1254259 2271 89371914
Mood altered 21.36 12.47 144 1254118 17000 89357185
Steroid dependence 21.36 12.47 3 1254259 2266 89371919
Pain in jaw 21.35 12.47 503 1253759 47482 89326703
Essential hypertension 21.30 12.47 34 1254228 6281 89367904
Joint dislocation 21.29 12.47 786 1253476 43796 89330389
Gastrointestinal necrosis 21.22 12.47 9 1254253 3216 89370969
Labelled drug-drug interaction issue 21.22 12.47 3 1254259 2255 89371930
Psychotic symptom 21.20 12.47 3 1254259 2253 89371932
Thyroiditis 21.13 12.47 12 1254250 3625 89370560
Blood uric acid increased 21.12 12.47 47 1254215 7657 89366528
Hip fracture 21.11 12.47 326 1253936 32751 89341434
Electric shock 21.11 12.47 62 1254200 1660 89372525
Klebsiella bacteraemia 21.02 12.47 5 1254257 2587 89371598
Pneumonia influenzal 21.00 12.47 3 1254259 2237 89371948
Haemothorax 20.97 12.47 4 1254258 2414 89371771
Myositis 20.89 12.47 223 1254039 23905 89350280
Multiple-drug resistance 20.86 12.47 48 1254214 7728 89366457
Anticipatory anxiety 20.82 12.47 50 1254212 1183 89373002
Leukoencephalopathy 20.80 12.47 22 1254240 4851 89369334
Nocardiosis 20.76 12.47 5 1254257 2565 89371620
Blood sodium increased 20.75 12.47 9 1254253 3173 89371012
Metastases to meninges 20.75 12.47 13 1254249 3722 89370463
Vascular access complication 20.72 12.47 77 1254185 2336 89371849
Hypertensive emergency 20.71 12.47 3 1254259 2214 89371971
Megacolon 20.67 12.47 3 1254259 2211 89371974
Immunisation 20.66 12.47 3 1254259 2210 89371975
Hiccups 20.64 12.47 8 1254254 3018 89371167
Infiltration anaesthesia 20.61 12.47 19 1254243 178 89374007
Carotid artery occlusion 20.59 12.47 35 1254227 6307 89367878
Troponin I increased 20.58 12.47 5 1254257 2550 89371635
Quadriparesis 20.51 12.47 5 1254257 2544 89371641
Internal haemorrhage 20.50 12.47 34 1254228 6186 89367999
Craniocerebral injury 20.46 12.47 10 1254252 3288 89370897
Anaphylactoid reaction 20.42 12.47 19 1254243 4449 89369736
Nasal ulcer 20.38 12.47 82 1254180 2584 89371601
Onychomycosis 20.36 12.47 669 1253593 36707 89337478
Rocky mountain spotted fever 20.33 12.47 11 1254251 38 89374147
Therapy change 20.27 12.47 54 1254208 8268 89365917
Rash pustular 20.24 12.47 185 1254077 7864 89366321
Hepatosplenic T-cell lymphoma 20.23 12.47 35 1254227 649 89373536
Anal haemorrhage 20.21 12.47 5 1254257 2519 89371666
Retinal toxicity 20.19 12.47 54 1254208 1368 89372817
Urinary sediment present 20.17 12.47 3 1254259 2171 89372014
Gastric disorder 20.15 12.47 605 1253657 32779 89341406
Hypochromic anaemia 20.13 12.47 3 1254259 2168 89372017
Malignant neoplasm of conjunctiva 20.12 12.47 11 1254251 39 89374146
Injection related reaction 20.12 12.47 46 1254216 1053 89373132
Carbohydrate antigen 125 increased 20.12 12.47 10 1254252 3256 89370929
Product preparation issue 20.09 12.47 4 1254258 2342 89371843
Iridocyclitis 20.04 12.47 102 1254160 3559 89370626
Hepatitis B virus test positive 19.94 12.47 20 1254242 210 89373975
Organ failure 19.90 12.47 9 1254253 3096 89371089
Thinking abnormal 19.86 12.47 89 1254173 11643 89362542
Infected bite 19.78 12.47 69 1254193 2028 89372157
Injection site streaking 19.73 12.47 10 1254252 29 89374156
Feeling drunk 19.73 12.47 22 1254240 4736 89369449
Nasal discharge discolouration 19.66 12.47 85 1254177 2768 89371417
Investigation abnormal 19.66 12.47 73 1254189 2214 89371971
Normochromic normocytic anaemia 19.65 12.47 25 1254237 5077 89369108
Hearing aid user 19.65 12.47 12 1254250 55 89374130
Pulse abnormal 19.62 12.47 9 1254253 3070 89371115
Weight bearing difficulty 19.61 12.47 85 1254177 2771 89371414
Haematocrit increased 19.61 12.47 9 1254253 3069 89371116
Secondary immunodeficiency 19.57 12.47 3 1254259 2123 89372062
Monoclonal immunoglobulin present 19.55 12.47 3 1254259 2121 89372064
Angle closure glaucoma 19.49 12.47 7 1254255 2768 89371417
Breast cancer stage I 19.48 12.47 68 1254194 9556 89364629
Bacterial sepsis 19.38 12.47 24 1254238 4931 89369254
Chorea 19.38 12.47 3 1254259 2107 89372078
Gestational diabetes 19.31 12.47 78 1254184 10504 89363681
Back disorder 19.30 12.47 478 1253784 25153 89349032
Rheumatic fever 19.27 12.47 2411 1251851 150710 89223475
Prothrombin time shortened 19.27 12.47 4 1254258 2274 89371911
Gallbladder disorder 19.25 12.47 178 1254084 19625 89354560
Trismus 19.23 12.47 23 1254239 4798 89369387
Chronic disease 19.20 12.47 19 1254243 196 89373989
Small intestinal haemorrhage 19.18 12.47 4 1254258 2267 89371918
Subacute cutaneous lupus erythematosus 19.17 12.47 13 1254249 3569 89370616
Pulmonary sarcoidosis 19.12 12.47 50 1254212 1249 89372936
Polyp 19.08 12.47 49 1254213 7595 89366590
Ear pruritus 19.07 12.47 41 1254221 6762 89367423
Intestinal haemorrhage 19.07 12.47 20 1254242 4427 89369758
Device defective 18.99 12.47 97 1254165 3389 89370796
Angiopathy 18.96 12.47 29 1254233 5451 89368734
Spinal disorder 18.96 12.47 246 1254016 11433 89362752
Animal scratch 18.84 12.47 62 1254200 1768 89372417
Urine leukocyte esterase positive 18.82 12.47 11 1254251 3271 89370914
Meniscus operation 18.71 12.47 15 1254247 114 89374071
Pharyngeal oedema 18.69 12.47 281 1253981 13490 89360695
Large intestinal ulcer 18.69 12.47 16 1254246 3901 89370284
Fungal infection 18.68 12.47 745 1253517 41916 89332269
Bladder disorder 18.67 12.47 81 1254181 10691 89363494
Enterocolitis infectious 18.59 12.47 3 1254259 2044 89372141
Toe amputation 18.59 12.47 67 1254195 2002 89372183
Neurological symptom 18.59 12.47 42 1254220 6805 89367380
Lip ulceration 18.51 12.47 70 1254192 2142 89372043
Listless 18.48 12.47 11 1254251 3238 89370947
Cerebral venous sinus thrombosis 18.47 12.47 5 1254257 2371 89371814
Dilatation ventricular 18.47 12.47 5 1254257 2371 89371814
Sensitive skin 18.46 12.47 12 1254250 3369 89370816
Non-small cell lung cancer 18.45 12.47 20 1254242 4361 89369824
Bite 18.45 12.47 29 1254233 495 89373690
Alcohol abuse 18.42 12.47 3 1254259 2030 89372155
Tendon disorder 18.40 12.47 157 1254105 6543 89367642
Device placement issue 18.38 12.47 3 1254259 2027 89372158
Coeliac disease 18.38 12.47 774 1253488 43836 89330349
Disease susceptibility 18.36 12.47 21 1254241 259 89373926
Wound infection pseudomonas 18.30 12.47 3 1254259 2020 89372165
International normalised ratio fluctuation 18.27 12.47 10 1254252 3083 89371102
Blood urine present 18.25 12.47 152 1254110 17126 89357059
Carbon dioxide decreased 18.22 12.47 8 1254254 2800 89371385
Infusion site infection 18.19 12.47 7 1254255 2653 89371532
Transaminases abnormal 18.15 12.47 35 1254227 708 89373477
Spinal laminectomy 18.14 12.47 38 1254224 818 89373367
Acinetobacter infection 18.11 12.47 3 1254259 2005 89372180
Steroid diabetes 18.11 12.47 6 1254256 2496 89371689
Lymph node pain 18.03 12.47 60 1254202 1721 89372464
Pelvic venous thrombosis 18.03 12.47 3 1254259 1998 89372187
Miliaria 18.00 12.47 53 1254209 1421 89372764
Extranodal marginal zone B-cell lymphoma (MALT type) 18.00 12.47 30 1254232 539 89373646
Intramedullary rod insertion 17.99 12.47 4 1254258 2168 89372017
Central venous catheterisation 17.98 12.47 8 1254254 2778 89371407
Hypertensive heart disease 17.97 12.47 7 1254255 2633 89371552
Dermatitis psoriasiform 17.95 12.47 79 1254183 2593 89371592
Device use issue 17.92 12.47 15 1254247 3698 89370487
Bursitis 17.88 12.47 2083 1252179 129571 89244614
Jugular vein thrombosis 17.86 12.47 14 1254248 3567 89370618
Ileal stenosis 17.84 12.47 6 1254256 2472 89371713
Bladder repair 17.82 12.47 14 1254248 103 89374082
Mucosal disorder 17.81 12.47 8 1254254 2763 89371422
Stem cell transplant 17.78 12.47 4 1254258 2150 89372035
Capillary leak syndrome 17.77 12.47 8 1254254 2759 89371426
Peripheral motor neuropathy 17.68 12.47 3 1254259 1970 89372215
Mood swings 17.66 12.47 192 1254070 20510 89353675
Conjunctival hyperaemia 17.65 12.47 11 1254251 3158 89371027
Bradyarrhythmia 17.64 12.47 6 1254256 2455 89371730
Dizziness postural 17.64 12.47 65 1254197 8988 89365197
Product taste abnormal 17.63 12.47 6 1254256 2454 89371731
Skin necrosis 17.61 12.47 331 1253931 16610 89357575
Pulmonary infarction 17.59 12.47 9 1254253 2883 89371302
Eye pruritus 17.55 12.47 289 1253973 28738 89345447
Sternal fracture 17.54 12.47 9 1254253 2878 89371307
Tongue biting 17.53 12.47 4 1254258 2129 89372056
Splenic infarction 17.45 12.47 4 1254258 2123 89372062
Refusal of treatment by patient 17.43 12.47 33 1254229 5705 89368480
Sacroiliitis 17.43 12.47 109 1254153 4110 89370075
Intervertebral disc compression 17.39 12.47 47 1254215 1198 89372987
Genital abscess 17.37 12.47 22 1254240 304 89373881
Varices oesophageal 17.35 12.47 16 1254246 3763 89370422
Tenderness 17.33 12.47 491 1253771 26377 89347808
Peptic ulcer haemorrhage 17.31 12.47 44 1254218 1080 89373105
Tendon rupture 17.31 12.47 200 1254062 9043 89365142
Spinal meningioma benign 17.30 12.47 14 1254248 108 89374077
Muscle atrophy 17.25 12.47 59 1254203 8342 89365843
Subileus 17.24 12.47 15 1254247 3629 89370556
Tinea pedis 17.24 12.47 55 1254207 1542 89372643
JC virus infection 17.24 12.47 8 1254254 2711 89371474
Anion gap increased 17.23 12.47 5 1254257 2265 89371920
Left atrial dilatation 17.23 12.47 3 1254259 1933 89372252
Cytomegalovirus chorioretinitis 17.16 12.47 6 1254256 2413 89371772
Apraxia 17.13 12.47 5 1254257 2257 89371928
Torticollis 17.06 12.47 7 1254255 2551 89371634
Lymphadenopathy 17.05 12.47 786 1253476 44989 89329196
Sputum culture positive 17.03 12.47 5 1254257 2248 89371937
Liver abscess 17.02 12.47 14 1254248 3482 89370703
Optic neuropathy 17.02 12.47 8 1254254 2690 89371495
False positive tuberculosis test 16.99 12.47 7 1254255 10 89374175
Hepatitis B reactivation 16.89 12.47 18 1254244 3956 89370229
Periodontitis 16.89 12.47 17 1254245 3836 89370349
Oesophageal candidiasis 16.87 12.47 44 1254218 6785 89367400
Appetite disorder 16.87 12.47 67 1254195 9066 89365119
Injection site hyperaesthesia 16.84 12.47 11 1254251 58 89374127
Gastrointestinal motility disorder 16.83 12.47 37 1254225 6054 89368131
Carotid artery stenosis 16.81 12.47 30 1254232 5304 89368881
Pelvic floor muscle weakness 16.80 12.47 12 1254250 75 89374110
Extradural haematoma 16.75 12.47 4 1254258 2064 89372121
Mean platelet volume decreased 16.72 12.47 83 1254179 2867 89371318
Urinary tract infection bacterial 16.70 12.47 39 1254223 6246 89367939
Tooth fracture 16.67 12.47 256 1254006 12344 89361841
Paraparesis 16.63 12.47 10 1254252 2928 89371257
Parathyroid disorder 16.63 12.47 35 1254227 756 89373429
Multiple fractures 16.63 12.47 204 1254058 9358 89364827
Gastric ulcer haemorrhage 16.62 12.47 30 1254232 5281 89368904
Device alarm issue 16.60 12.47 3 1254259 1882 89372303
Microcytic anaemia 16.56 12.47 17 1254245 3801 89370384
Blood glucose fluctuation 16.55 12.47 28 1254234 5055 89369130
Seroma 16.52 12.47 11 1254251 3049 89371136
Polyhydramnios 16.50 12.47 7 1254255 2501 89371684
Pericardial haemorrhage 16.49 12.47 3 1254259 1873 89372312
Sunburn 16.49 12.47 89 1254173 3178 89371007
Neck mass 16.48 12.47 101 1254161 3781 89370404
Infected bunion 16.47 12.47 5 1254257 0 89374185
Smear cervix 16.47 12.47 5 1254257 0 89374185
Multi-organ disorder 16.42 12.47 5 1254257 2195 89371990
Large intestinal stenosis 16.38 12.47 7 1254255 2490 89371695
Bursa disorder 16.34 12.47 17 1254245 187 89373998
Pneumomediastinum 16.31 12.47 4 1254258 2027 89372158
Device mechanical issue 16.30 12.47 43 1254219 1080 89373105
Nasal mucosal disorder 16.26 12.47 3 1254259 1854 89372331
Gingival injury 16.24 12.47 9 1254253 33 89374152
Respiratory symptom 16.21 12.47 21 1254241 4231 89369954
Product container issue 16.20 12.47 5 1254257 2176 89372009
Ear congestion 16.19 12.47 92 1254170 3350 89370835
Mucosal erosion 16.11 12.47 3 1254259 1842 89372343
Humerus fracture 16.11 12.47 75 1254187 9710 89364475
Norovirus infection 16.10 12.47 3 1254259 1841 89372344
Nasal obstruction 16.08 12.47 8 1254254 2604 89371581
Blood creatinine decreased 16.08 12.47 42 1254220 6473 89367712
Autoimmune hepatitis 16.07 12.47 81 1254181 10270 89363915
Strabismus 16.06 12.47 7 1254255 2461 89371724
Syringe issue 16.06 12.47 19 1254243 3983 89370202
Nephrogenic anaemia 16.04 12.47 7 1254255 2459 89371726
Liver transplant 16.01 12.47 6 1254256 2311 89371874
Adrenocortical insufficiency acute 15.97 12.47 8 1254254 2593 89371592
Recurrent cancer 15.96 12.47 7 1254255 2452 89371733
Oesophageal ulcer 15.94 12.47 29 1254233 5090 89369095
Mouth haemorrhage 15.94 12.47 62 1254200 8439 89365746
Pelvic inflammatory disease 15.93 12.47 3 1254259 1827 89372358
Gastrointestinal inflammation 15.90 12.47 44 1254218 6652 89367533
Device allergy 15.87 12.47 10 1254252 49 89374136
Multiple system atrophy 15.87 12.47 17 1254245 194 89373991
Metastases to spine 15.86 12.47 17 1254245 3726 89370459
Infected dermal cyst 15.84 12.47 26 1254236 461 89373724
Needle issue 15.80 12.47 276 1253986 13658 89360527
Intercepted product administration error 15.79 12.47 37 1254225 861 89373324
Intra-abdominal haematoma 15.77 12.47 5 1254257 2139 89372046
Acute lymphocytic leukaemia 15.70 12.47 10 1254252 2838 89371347
Breast scan 15.69 12.47 6 1254256 6 89374179
Vocal cord paralysis 15.64 12.47 7 1254255 2423 89371762
Hyperparathyroidism secondary 15.57 12.47 3 1254259 1798 89372387
Nail bed inflammation 15.57 12.47 3 1254259 1798 89372387
Antinuclear antibody positive 15.57 12.47 196 1254066 9045 89365140
Melkersson-Rosenthal syndrome 15.56 12.47 7 1254255 14 89374171
Paraesthesia 15.53 12.47 3142 1251120 247184 89127001
Contraindication to medical treatment 15.51 12.47 38 1254224 911 89373274
Abdominal abscess 15.49 12.47 32 1254230 5355 89368830
Hyporeflexia 15.44 12.47 6 1254256 2260 89371925
Hyperphagia 15.39 12.47 10 1254252 2808 89371377
Spinal nerve stimulator implantation 15.37 12.47 15 1254247 152 89374033
Emotional disorder 15.37 12.47 133 1254129 14864 89359321
Hodgkin's disease 15.34 12.47 33 1254229 724 89373461
Infected cyst 15.32 12.47 45 1254217 1205 89372980
Dysaesthesia 15.29 12.47 31 1254231 5224 89368961
Hypothalamo-pituitary disorder 15.28 12.47 6 1254256 2246 89371939
Apparent death 15.21 12.47 44 1254218 1168 89373017
Pneumocystis jirovecii pneumonia 15.21 12.47 209 1254053 21407 89352778
Osteolysis 15.18 12.47 16 1254246 3534 89370651
Soft tissue injury 15.17 12.47 5 1254257 2087 89372098
Snoring 15.12 12.47 30 1254232 5096 89369089
Burning sensation 15.12 12.47 1046 1253216 62406 89311779
Sudden cardiac death 15.06 12.47 6 1254256 2226 89371959
Pulmonary sepsis 15.05 12.47 6 1254256 2225 89371960
Paraplegia 15.02 12.47 15 1254247 3397 89370788
Streptococcal bacteraemia 15.00 12.47 6 1254256 2221 89371964
Kyphosis 14.98 12.47 11 1254251 2897 89371288
Nervousness 14.98 12.47 595 1253667 33461 89340724
Mean cell haemoglobin concentration abnormal 14.96 12.47 14 1254248 134 89374051
Bone marrow disorder 14.94 12.47 12 1254250 3020 89371165
Epidermal necrosis 14.89 12.47 7 1254255 2354 89371831
Labile blood pressure 14.88 12.47 4 1254258 1906 89372279
Poor quality sleep 14.88 12.47 246 1254016 24447 89349738
Micturition disorder 14.82 12.47 12 1254250 3008 89371177
Vaginal operation 14.79 12.47 6 1254256 8 89374177
Anticonvulsant drug level increased 14.78 12.47 3 1254259 1733 89372452
Portal vein thrombosis 14.75 12.47 13 1254249 3125 89371060
Enterocolitis haemorrhagic 14.74 12.47 3 1254259 1729 89372456
Dactylitis 14.74 12.47 98 1254164 3775 89370410
Foetal death 14.71 12.47 200 1254062 20523 89353662
Intentional underdose 14.68 12.47 5 1254257 2044 89372141
Hepatorenal syndrome 14.67 12.47 5 1254257 2043 89372142
Hair colour changes 14.66 12.47 16 1254246 3478 89370707
Peripheral sensorimotor neuropathy 14.64 12.47 5 1254257 2040 89372145
Vascular pseudoaneurysm 14.63 12.47 3 1254259 1720 89372465
Tumour pain 14.61 12.47 4 1254258 1883 89372302
Product administered at inappropriate site 14.59 12.47 103 1254159 4048 89370137
Product use issue 14.58 12.47 4935 1249327 324984 89049201
Erythema 14.56 12.47 3481 1250781 225765 89148420
Biliary colic 14.55 12.47 21 1254241 4042 89370143
Cutaneous vasculitis 14.54 12.47 158 1254104 7035 89367150
Synovial disorder 14.44 12.47 83 1254179 3035 89371150
Diabetic eye disease 14.42 12.47 15 1254247 165 89374020
Rhonchi 14.41 12.47 12 1254250 2966 89371219
Blood creatinine abnormal 14.38 12.47 22 1254240 4135 89370050
Idiopathic intracranial hypertension 14.37 12.47 17 1254245 3564 89370621
Large intestinal obstruction 14.33 12.47 10 1254252 2704 89371481
Hyperparathyroidism 14.32 12.47 15 1254247 3322 89370863
Thrombocytopenic purpura 14.31 12.47 4 1254258 1857 89372328
Abnormal uterine bleeding 14.26 12.47 5 1254257 2007 89372178
Swollen joint count increased 14.25 12.47 1753 1252509 109453 89264732
Myelopathy 14.20 12.47 16 1254246 3428 89370757
Focal segmental glomerulosclerosis 14.19 12.47 4 1254258 1847 89372338
Rheumatoid nodule removal 14.16 12.47 5 1254257 3 89374182
Poor quality device used 14.15 12.47 7 1254255 2286 89371899
Bone density abnormal 14.13 12.47 102 1254160 4038 89370147
Ligament operation 14.11 12.47 8 1254254 31 89374154
Talipes 14.11 12.47 3 1254259 1677 89372508
Gastric polyps 14.08 12.47 27 1254235 4645 89369540
Vitamin B12 decreased 14.07 12.47 33 1254229 5277 89368908
Mallory-Weiss syndrome 14.05 12.47 3 1254259 1672 89372513
Papule 14.04 12.47 171 1254091 7831 89366354
Lymphangiosis carcinomatosa 14.01 12.47 3 1254259 1669 89372516
Staphylococcal skin infection 13.98 12.47 43 1254219 1182 89373003
Cerebrovascular disorder 13.96 12.47 11 1254251 2795 89371390
Breast cancer recurrent 13.95 12.47 35 1254227 5468 89368717
Meningoradiculitis 13.92 12.47 13 1254249 124 89374061
Muscle contractions involuntary 13.92 12.47 12 1254250 2916 89371269
Vein rupture 13.88 12.47 3 1254259 1658 89372527
Salivary gland disorder 13.85 12.47 17 1254245 227 89373958
Feeling hot 13.85 12.47 1257 1253005 76751 89297434
Plantar fasciitis 13.84 12.47 104 1254158 4170 89370015
Arthroscopic surgery 13.83 12.47 12 1254250 103 89374082
Ureteric obstruction 13.80 12.47 6 1254256 2112 89372073
Catheterisation cardiac 13.78 12.47 30 1254232 4926 89369259
Blood bilirubin abnormal 13.72 12.47 5 1254257 1959 89372226
Bladder operation 13.68 12.47 38 1254224 985 89373200
Musculoskeletal injury 13.67 12.47 14 1254248 151 89374034
Blood iron increased 13.66 12.47 5 1254257 1954 89372231
Caesarean section 13.66 12.47 178 1254084 18399 89355786
Tongue neoplasm malignant stage unspecified 13.63 12.47 36 1254226 905 89373280
Thyroid cancer 13.62 12.47 140 1254122 6144 89368041
Ephelides 13.58 12.47 11 1254251 85 89374100
Oesophageal stenosis 13.57 12.47 20 1254242 3816 89370369
Loss of employment 13.50 12.47 79 1254183 2908 89371277
Quadriplegia 13.49 12.47 7 1254255 2224 89371961
Extremity contracture 13.48 12.47 44 1254218 1249 89372936
Pleuritic pain 13.47 12.47 87 1254175 10374 89363811
Presbyacusis 13.46 12.47 80 1254182 2962 89371223
Biliary obstruction 13.45 12.47 16 1254246 3346 89370839
Oesophageal spasm 13.44 12.47 16 1254246 3345 89370840
Toxoplasmosis 13.42 12.47 4 1254258 1781 89372404
Bipolar I disorder 13.40 12.47 6 1254256 2076 89372109
Labour induction 13.39 12.47 12 1254250 108 89374077
Bone deformity 13.39 12.47 27 1254235 565 89373620
Blood cholesterol decreased 13.34 12.47 5 1254257 1926 89372259
Pharyngeal operation 13.34 12.47 6 1254256 12 89374173
Needle track marks 13.34 12.47 6 1254256 12 89374173
Enterococcal sepsis 13.34 12.47 3 1254259 1613 89372572
Superinfection 13.34 12.47 14 1254248 3098 89371087
Red blood cells urine positive 13.28 12.47 15 1254247 3210 89370975
Palindromic rheumatism 13.24 12.47 15 1254247 183 89374002
Urinary tract operation 13.18 12.47 4 1254258 0 89374185
Mycobacterium tuberculosis complex test 13.18 12.47 4 1254258 0 89374185
Joint adhesion 13.18 12.47 4 1254258 0 89374185
Cor pulmonale 13.16 12.47 6 1254256 2054 89372131
Menstruation irregular 13.14 12.47 62 1254200 7998 89366187
Anaesthetic complication 13.12 12.47 9 1254253 2456 89371729
Tic 13.12 12.47 5 1254257 1906 89372279
Asthmatic crisis 13.11 12.47 5 1254257 1905 89372280
Suicidal behaviour 13.11 12.47 12 1254250 2832 89371353
Ligament disorder 13.09 12.47 23 1254239 432 89373753
Mast cell activation syndrome 13.08 12.47 3 1254259 1591 89372594
Optic ischaemic neuropathy 13.04 12.47 4 1254258 1748 89372437
Ovarian cancer recurrent 13.03 12.47 3 1254259 1587 89372598
Acute febrile neutrophilic dermatosis 13.01 12.47 18 1254244 3527 89370658
Enterobacter infection 13.01 12.47 10 1254252 2573 89371612
Metastases to pleura 12.98 12.47 6 1254256 2038 89372147
Hepatitis E 12.98 12.47 5 1254257 1894 89372291
Gastrointestinal oedema 12.98 12.47 3 1254259 1583 89372602
Biopsy breast 12.98 12.47 18 1254244 273 89373912
Gastric infection 12.97 12.47 97 1254165 3883 89370302
Dysphemia 12.95 12.47 14 1254248 3056 89371129
Ovarian cancer 12.93 12.47 147 1254115 6620 89367565
Bile duct stenosis 12.92 12.47 4 1254258 1738 89372447
Skin candida 12.91 12.47 4 1254258 1737 89372448
Lupus vasculitis 12.89 12.47 27 1254235 581 89373604
Vascular purpura 12.88 12.47 4 1254258 1734 89372451
Episcleritis 12.87 12.47 41 1254221 1149 89373036
Lupus-like syndrome 12.85 12.47 812 1253450 48034 89326151
Premature rupture of membranes 12.84 12.47 37 1254225 5521 89368664
Conduction disorder 12.84 12.47 4 1254258 1731 89372454
Enterocutaneous fistula 12.84 12.47 3 1254259 1571 89372614
Enteritis infectious 12.82 12.47 9 1254253 2426 89371759
Regurgitation 12.80 12.47 7 1254255 2159 89372026
Madarosis 12.76 12.47 19 1254243 3610 89370575
Blood catecholamines decreased 12.73 12.47 6 1254256 14 89374171
Mole excision 12.69 12.47 16 1254246 220 89373965
Intestinal sepsis 12.65 12.47 19 1254243 311 89373874
Exposure via partner 12.65 12.47 12 1254250 117 89374068
Upper respiratory tract inflammation 12.64 12.47 11 1254251 2661 89371524
Pelvic fracture 12.64 12.47 142 1254120 15077 89359108
Colitis microscopic 12.64 12.47 221 1254041 10938 89363247
Metastatic bronchial carcinoma 12.64 12.47 15 1254247 193 89373992
Overwork 12.63 12.47 9 1254253 56 89374129
Anorectal discomfort 12.61 12.47 14 1254248 3020 89371165
Non-small cell lung cancer stage II 12.61 12.47 5 1254257 6 89374179
Compartment syndrome 12.59 12.47 13 1254249 2899 89371286
Body tinea 12.58 12.47 61 1254201 2087 89372098
Myoglobin blood increased 12.57 12.47 3 1254259 1549 89372636
Flat affect 12.57 12.47 4 1254258 1707 89372478
Oral herpes 12.56 12.47 576 1253686 32948 89341237
Dyspareunia 12.55 12.47 12 1254250 2774 89371411
Lichenoid keratosis 12.52 12.47 10 1254252 2524 89371661
Interstitial lung disease 12.52 12.47 899 1253363 75506 89298679
Postural orthostatic tachycardia syndrome 12.49 12.47 8 1254254 2264 89371921
Medical device discomfort 12.48 12.47 7 1254255 2129 89372056

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Injection site pain 10049.29 13.99 5417 241514 52381 42322023
Injection site erythema 7006.76 13.99 3043 243888 17152 42357252
Arthralgia 4869.57 13.99 5952 240979 199286 42175118
Drug ineffective 4004.34 13.99 10186 236745 620011 41754393
Injection site swelling 3914.59 13.99 1928 245003 15045 42359359
Injection site pruritus 3678.34 13.99 1544 245387 7861 42366543
Injection site reaction 3110.07 13.99 1610 245321 14111 42360293
Therapeutic product effect decreased 3017.31 13.99 2193 244738 36957 42337447
Joint swelling 2885.39 13.99 2692 244239 65330 42309074
Injection site bruising 2674.05 13.99 1315 245616 10210 42364194
Injection site haemorrhage 2618.82 13.99 1304 245627 10432 42363972
Wrong technique in product usage process 2618.52 13.99 2086 244845 40549 42333855
Nasopharyngitis 2572.52 13.99 2786 244145 81210 42293194
Pain in extremity 2296.27 13.99 3534 243397 147070 42227334
Pain 2273.43 13.99 4619 242312 240229 42134175
Therapeutic product effect incomplete 2188.90 13.99 2363 244568 68576 42305828
Musculoskeletal stiffness 1819.67 13.99 1946 244985 55819 42318585
Accidental exposure to product 1720.89 13.99 1208 245723 19185 42355219
Product dose omission issue 1708.15 13.99 3140 243791 151225 42223179
Injection site warmth 1633.81 13.99 607 246324 2076 42372328
Acute kidney injury 1479.57 13.99 193 246738 367144 42007260
Product storage error 1425.14 13.99 857 246074 10283 42364121
Mobility decreased 1383.97 13.99 1339 245592 33967 42340437
Device issue 1345.99 13.99 887 246044 12622 42361782
Injection site rash 1340.24 13.99 657 246274 5055 42369349
Psoriasis 1174.72 13.99 1428 245503 47176 42327228
Sinusitis 1135.70 13.99 1385 245546 45907 42328497
Toxicity to various agents 1100.71 13.99 55 246876 229081 42145323
Therapeutic response decreased 1100.20 13.99 1210 245721 35802 42338602
Drug interaction 1081.84 13.99 137 246794 266862 42107542
Joint stiffness 1081.57 13.99 748 246183 11574 42362830
Musculoskeletal pain 997.89 13.99 1094 245837 32246 42342158
Arthropathy 980.67 13.99 1025 245906 28572 42345832
Arthritis 960.09 13.99 1201 245730 40864 42333540
Hypotension 924.82 13.99 185 246746 257446 42116958
Psoriatic arthropathy 916.83 13.99 914 246017 24053 42350351
Anaemia 913.65 13.99 248 246683 280030 42094374
Febrile neutropenia 906.39 13.99 40 246891 185663 42188741
Underdose 905.48 13.99 760 246171 15906 42358498
Treatment failure 871.76 13.99 1412 245519 61212 42313192
Synovitis 862.52 13.99 718 246213 14849 42359555
Skin plaque 747.04 13.99 450 246481 5413 42368991
Knee arthroplasty 716.89 13.99 510 246421 8271 42366133
Death 710.70 13.99 1021 245910 470164 41904240
Injection site mass 683.88 13.99 491 246440 8084 42366320
Injection site discomfort 638.96 13.99 299 246632 2047 42372357
Injection site discolouration 636.86 13.99 281 246650 1645 42372759
Swelling 619.60 13.99 1128 245803 53757 42320647
Neutropenia 611.79 13.99 197 246734 199234 42175170
Thrombocytopenia 608.91 13.99 174 246757 190105 42184299
Injection site induration 584.39 13.99 320 246611 3167 42371237
Injection site extravasation 577.73 13.99 306 246625 2816 42371588
Malignant neoplasm progression 577.40 13.99 10 246921 108390 42266014
Contraindicated product administered 567.53 13.99 716 246215 24556 42349848
Injection site urticaria 543.70 13.99 302 246629 3081 42371323
Peripheral swelling 541.15 13.99 1438 245493 88832 42285572
Diarrhoea 534.27 13.99 1176 245755 459673 41914731
Confusional state 522.02 13.99 161 246770 167436 42206968
Drug abuse 487.46 13.99 30 246901 104741 42269663
Hyponatraemia 481.39 13.99 26 246905 101436 42272968
Influenza 478.18 13.99 1090 245841 61085 42313319
Disease progression 475.13 13.99 123 246808 143533 42230871
Vomiting 470.93 13.99 593 246338 289130 42085274
Dyspnoea 468.47 13.99 1185 245746 441436 41932968
Completed suicide 456.78 13.99 25 246906 96440 42277964
C-reactive protein abnormal 445.44 13.99 394 246537 8867 42365537
Surgery 443.86 13.99 529 246402 17087 42357317
Constipation 438.04 13.99 196 246735 162095 42212309
Drug intolerance 426.24 13.99 1225 245706 79199 42295205
Rhabdomyolysis 404.30 13.99 10 246921 78009 42296395
Hyperkalaemia 400.01 13.99 15 246916 80443 42293961
Dehydration 389.19 13.99 167 246764 141600 42232804
Bone erosion 385.60 13.99 267 246664 4136 42370268
Back pain 383.20 13.99 1732 245199 140044 42234360
Respiratory tract congestion 375.96 13.99 330 246601 7348 42367056
Injection site haematoma 371.32 13.99 194 246737 1731 42372673
Hip arthroplasty 369.49 13.99 280 246651 5025 42369379
Product use in unapproved indication 362.73 13.99 321 246610 184135 42190269
Bradycardia 362.70 13.99 37 246894 85447 42288957
Apparent death 355.97 13.99 238 246693 3470 42370934
Headache 354.28 13.99 2486 244445 236883 42137521
Therapy interrupted 348.54 13.99 530 246401 21720 42352684
Tachycardia 344.93 13.99 81 246850 101006 42273398
Iritis 339.20 13.99 178 246753 1604 42372800
Respiratory failure 339.03 13.99 159 246772 127973 42246431
Decreased appetite 335.12 13.99 375 246556 192762 42181642
Hypokalaemia 329.19 13.99 22 246909 71699 42302705
Unevaluable event 329.14 13.99 658 246273 33630 42340774
Hand deformity 328.82 13.99 228 246703 3540 42370864
Cardiac arrest 326.13 13.99 113 246818 109207 42265197
Pancytopenia 313.21 13.99 145 246786 117598 42256806
Therapy non-responder 311.39 13.99 842 246089 52517 42321887
General physical health deterioration 308.51 13.99 254 246677 150992 42223412
Rheumatoid arthritis 298.83 13.99 719 246212 41721 42332683
Blood creatinine increased 298.00 13.99 132 246799 109871 42264533
Oropharyngeal pain 291.64 13.99 713 246218 41797 42332607
Neck pain 289.29 13.99 577 246354 29437 42344967
Hypoxia 288.90 13.99 33 246898 69753 42304651
Seizure 288.82 13.99 170 246761 120391 42254013
Drug hypersensitivity 284.81 13.99 1236 245695 98153 42276251
Diverticulitis 283.80 13.99 489 246442 22284 42352120
Disability 282.50 13.99 251 246680 5682 42368722
Abdominal pain 280.69 13.99 418 246513 190053 42184351
Gastrointestinal haemorrhage 279.68 13.99 108 246823 97618 42276786
Infection 278.99 13.99 1337 245594 110731 42263673
Hypoglycaemia 275.74 13.99 18 246913 59836 42314568
Tuberculin test positive 274.79 13.99 135 246796 1043 42373361
Overdose 274.78 13.99 133 246798 105131 42269273
Osteoarthritis 274.45 13.99 501 246430 23904 42350500
Neutrophil count decreased 272.78 13.99 26 246905 63389 42311015
Red blood cell sedimentation rate increased 271.62 13.99 311 246620 9613 42364791
Platelet count decreased 271.30 13.99 242 246689 138339 42236065
Syncope 268.12 13.99 120 246811 99286 42275118
Localised infection 266.48 13.99 447 246484 19926 42354478
Herpes zoster 263.42 13.99 649 246282 38228 42336176
Renal impairment 263.22 13.99 156 246775 110072 42264332
Musculoskeletal disorder 262.16 13.99 253 246678 6385 42368019
Electrocardiogram QT prolonged 261.34 13.99 3 246928 47942 42326462
Intentional overdose 257.78 13.99 9 246922 51447 42322957
Somnolence 256.86 13.99 263 246668 140842 42233562
Pyrexia 255.72 13.99 1295 245636 392747 41981657
Foot deformity 252.50 13.99 220 246711 4848 42369556
Metabolic acidosis 249.97 13.99 12 246919 51846 42322558
Incorrect dose administered by device 248.11 13.99 170 246761 2586 42371818
Intentional product misuse 246.10 13.99 854 246077 61046 42313358
Feeling abnormal 243.74 13.99 923 246008 68863 42305541
Red blood cell sedimentation rate abnormal 242.14 13.99 191 246740 3645 42370759
Cardio-respiratory arrest 237.10 13.99 30 246901 58606 42315798
Agitation 236.98 13.99 43 246888 64271 42310133
Haemoglobin decreased 230.94 13.99 256 246675 132215 42242189
Grip strength decreased 229.39 13.99 180 246751 3408 42370996
Joint range of motion decreased 225.88 13.99 251 246680 7502 42366902
Atrial fibrillation 223.93 13.99 288 246643 139305 42235099
Joint lock 223.54 13.99 124 246807 1261 42373143
Inflammation 222.94 13.99 559 246372 33288 42341116
Chondropathy 221.27 13.99 118 246813 1102 42373302
International normalised ratio increased 220.36 13.99 15 246916 48153 42326251
Lactic acidosis 216.47 13.99 11 246920 45250 42329154
Septic shock 215.67 13.99 132 246799 91540 42282864
Rhinorrhoea 213.52 13.99 529 246402 31265 42343139
Sepsis 212.86 13.99 530 246401 198804 42175600
Delirium 212.03 13.99 27 246904 52492 42321912
Suicide attempt 211.94 13.99 14 246917 46086 42328318
Skin laceration 211.89 13.99 329 246602 13729 42360675
Foetal exposure during pregnancy 209.97 13.99 17 246914 47294 42327110
Hypersensitivity 208.75 13.99 902 246029 71468 42302936
Injection site irritation 207.53 13.99 126 246805 1538 42372866
Limb discomfort 205.43 13.99 308 246623 12459 42361945
Hallucination 204.36 13.99 42 246889 57465 42316939
Multiple organ dysfunction syndrome 203.98 13.99 158 246773 96877 42277527
Uveitis 202.54 13.99 259 246672 8999 42365405
Device difficult to use 202.23 13.99 186 246745 4410 42369994
Paranasal sinus hypersecretion 196.84 13.99 108 246823 1073 42373331
Finger deformity 196.73 13.99 121 246810 1514 42372890
Cardiac failure 195.73 13.99 198 246733 106658 42267746
Drug reaction with eosinophilia and systemic symptoms 192.77 13.99 13 246918 42062 42332342
Coma 192.63 13.99 38 246893 53516 42320888
Oxygen saturation decreased 190.90 13.99 68 246863 64619 42309785
Depressed level of consciousness 190.45 13.99 26 246905 47944 42326460
Sinus congestion 189.77 13.99 218 246713 6762 42367642
Sarcoidosis 187.81 13.99 162 246769 3520 42370884
Pneumonia aspiration 187.72 13.99 32 246899 50046 42324358
Myelosuppression 186.85 13.99 12 246919 40449 42333955
Injury associated with device 185.15 13.99 110 246821 1287 42373117
Injection site macule 183.97 13.99 47 246884 13 42374391
Sleep disorder due to general medical condition, insomnia type 180.04 13.99 110 246821 1359 42373045
Blood pressure decreased 179.66 13.99 57 246874 58275 42316129
Injection site vesicles 177.72 13.99 105 246826 1215 42373189
Mental status changes 176.60 13.99 19 246912 42096 42332308
Musculoskeletal discomfort 176.43 13.99 245 246686 9231 42365173
Mycobacterium tuberculosis complex test positive 175.52 13.99 110 246821 1426 42372978
Hyperglycaemia 174.80 13.99 28 246903 45831 42328573
Fear of injection 174.30 13.99 121 246810 1882 42372522
Impaired healing 174.19 13.99 336 246595 16717 42357687
Melaena 171.72 13.99 14 246917 38732 42335672
Knee operation 171.41 13.99 133 246798 2475 42371929
Condition aggravated 171.19 13.99 2282 244649 258472 42115932
Upper respiratory tract infection 168.57 13.99 583 246348 41590 42332814
Lymphoma 167.37 13.99 299 246632 14022 42360382
Plasma cell myeloma 166.48 13.99 36 246895 47542 42326862
Fall 165.60 13.99 747 246184 233773 42140631
Gait disturbance 161.96 13.99 1047 245884 96953 42277451
Therapy cessation 160.92 13.99 362 246569 20088 42354316
Blood creatine phosphokinase increased 158.48 13.99 42 246889 48296 42326108
Ankylosing spondylitis 158.47 13.99 200 246731 6856 42367548
Shoulder operation 155.41 13.99 100 246831 1361 42373043
Iridocyclitis 154.63 13.99 117 246814 2094 42372310
Mass 153.89 13.99 220 246711 8519 42365885
Loss of consciousness 153.84 13.99 185 246746 92169 42282235
Injection site recall reaction 153.80 13.99 37 246894 0 42374404
Sedation 153.80 13.99 5 246926 30470 42343934
Therapeutic product effect delayed 151.49 13.99 100 246831 1425 42372979
Spinal fusion surgery 150.55 13.99 92 246839 1137 42373267
Respiratory distress 149.71 13.99 30 246901 41790 42332614
Neoplasm progression 149.12 13.99 4 246927 28996 42345408
Bronchitis 148.30 13.99 604 246327 46597 42327807
Orthostatic hypotension 147.55 13.99 7 246924 30563 42343841
Unresponsive to stimuli 145.94 13.99 9 246922 31394 42343010
Infusion related reaction 145.16 13.99 86 246845 60720 42313684
Spinal operation 144.78 13.99 149 246782 4071 42370333
Ill-defined disorder 143.65 13.99 302 246629 15994 42358410
Urinary retention 143.57 13.99 34 246897 42180 42332224
Cardiogenic shock 142.23 13.99 19 246912 35621 42338783
Joint effusion 141.83 13.99 173 246758 5724 42368680
Aggression 141.73 13.99 40 246891 44123 42330281
Ascites 139.82 13.99 77 246854 56601 42317803
Dysphagia 138.62 13.99 130 246801 72589 42301815
Tooth infection 137.15 13.99 199 246732 7812 42366592
Weight decreased 136.40 13.99 680 246251 207268 42167136
Arthropod bite 133.80 13.99 127 246804 3137 42371267
Neuropathy peripheral 133.53 13.99 241 246690 101612 42272792
Haematuria 133.45 13.99 85 246846 57714 42316690
Joint noise 132.92 13.99 79 246852 925 42373479
Tubulointerstitial nephritis 132.87 13.99 14 246917 31534 42342870
Blood bilirubin increased 132.42 13.99 40 246891 42212 42332192
Rash maculo-papular 131.98 13.99 28 246903 37475 42336929
Hypoacusis 131.75 13.99 317 246614 18385 42356019
Cerebral haemorrhage 131.31 13.99 32 246899 38934 42335470
Acute myocardial infarction 129.62 13.99 89 246842 58076 42316328
Malaise 128.62 13.99 1831 245100 210325 42164079
Asthenia 128.14 13.99 1027 245904 279766 42094638
Encephalopathy 127.97 13.99 40 246891 41293 42333111
Joint destruction 127.19 13.99 57 246874 348 42374056
Drug level increased 126.45 13.99 6 246925 26194 42348210
Cholestasis 125.47 13.99 20 246911 32859 42341545
Decreased immune responsiveness 124.31 13.99 101 246830 2014 42372390
Hypomagnesaemia 124.30 13.99 11 246920 28477 42345927
Wheezing 123.17 13.99 83 246848 54698 42319706
Haemorrhage 122.99 13.99 102 246829 60461 42313943
Agranulocytosis 122.92 13.99 16 246915 30596 42343808
Neurotoxicity 122.60 13.99 3 246928 23648 42350756
Tooth fracture 121.09 13.99 135 246796 4049 42370355
Hypocalcaemia 120.60 13.99 16 246915 30157 42344247
Drug dose omission by device 119.93 13.99 159 246772 5727 42368677
Mucosal inflammation 119.03 13.99 69 246862 49305 42325099
Furuncle 118.99 13.99 127 246804 3623 42370781
Pleural effusion 118.54 13.99 240 246691 96926 42277478
Haematemesis 118.38 13.99 17 246914 30182 42344222
Bone marrow failure 117.91 13.99 24 246907 33069 42341335
Toxic epidermal necrolysis 117.61 13.99 10 246921 26740 42347664
Nodule 117.20 13.99 238 246693 12296 42362108
Chronic kidney disease 116.78 13.99 64 246867 47177 42327227
Shoulder arthroplasty 116.29 13.99 67 246864 737 42373667
Hypervolaemia 115.97 13.99 4 246927 23121 42351283
Device malfunction 115.18 13.99 234 246697 12093 42362311
Loss of personal independence in daily activities 114.99 13.99 582 246349 49234 42325170
Tumour lysis syndrome 114.55 13.99 3 246928 22228 42352176
Circumstance or information capable of leading to medication error 114.52 13.99 104 246827 2424 42371980
Urticaria 114.42 13.99 778 246153 73258 42301146
Joint arthroplasty 114.24 13.99 71 246860 906 42373498
Sinus disorder 113.85 13.99 183 246748 7867 42366537
Nasal congestion 113.70 13.99 403 246528 29098 42345306
Ventricular fibrillation 113.44 13.99 19 246912 30104 42344300
Hypoaesthesia 112.86 13.99 755 246176 70708 42303696
Influenza like illness 112.63 13.99 423 246508 31417 42342987
Blood pressure increased 111.81 13.99 267 246664 101661 42272743
Sneezing 111.76 13.99 160 246771 6203 42368201
Foot operation 111.24 13.99 64 246867 702 42373702
Demyelination 111.07 13.99 119 246812 3410 42370994
Psychotic disorder 110.93 13.99 18 246913 29190 42345214
Lymphocyte count decreased 110.55 13.99 15 246916 27794 42346610
Pneumonitis 109.88 13.99 52 246879 41666 42332738
Synovial cyst 109.12 13.99 103 246828 2526 42371878
Dysarthria 108.93 13.99 47 246884 39760 42334644
No adverse event 108.50 13.99 45 246886 38976 42335428
Upper gastrointestinal haemorrhage 107.90 13.99 22 246909 30277 42344127
Rheumatoid nodule 106.84 13.99 108 246823 2887 42371517
Nausea 106.24 13.99 1639 245292 395160 41979244
Bone cyst 105.92 13.99 83 246848 1568 42372836
Haemoptysis 105.06 13.99 69 246862 46098 42328306
Adverse event 103.47 13.99 337 246594 23303 42351101
Ear infection 103.36 13.99 229 246702 12575 42361829
Leukopenia 103.30 13.99 171 246760 74575 42299829
Cough 103.07 13.99 1525 245406 176578 42197826
Suicidal ideation 102.97 13.99 77 246854 48084 42326320
Altered state of consciousness 102.64 13.99 22 246909 29237 42345167
Enthesopathy 102.36 13.99 133 246798 4695 42369709
Contusion 102.21 13.99 498 246433 41487 42332917
Diabetic ketoacidosis 102.19 13.99 7 246924 22360 42352044
Abdominal distension 102.06 13.99 161 246770 71574 42302830
Rheumatoid factor negative 101.96 13.99 67 246864 947 42373457
Palmar-plantar erythrodysaesthesia syndrome 101.69 13.99 4 246927 20578 42353826
Tuberculosis 100.71 13.99 197 246734 9902 42364502
Adverse reaction 100.70 13.99 120 246811 3873 42370531
COVID-19 99.78 13.99 341 246590 115607 42258797
Sinus headache 99.72 13.99 71 246860 1152 42373252
Impaired work ability 99.59 13.99 218 246713 11873 42362531
Heart rate increased 98.23 13.99 98 246833 53157 42321247
Oedema 97.88 13.99 94 246837 51907 42322497
Blood glucose increased 97.82 13.99 173 246758 73526 42300878
Injection site papule 97.79 13.99 46 246885 319 42374085
Drug withdrawal syndrome 97.71 13.99 7 246924 21542 42352862
Cardiac failure congestive 97.28 13.99 220 246711 85382 42289022
Anti-cyclic citrullinated peptide antibody positive 97.27 13.99 84 246847 1828 42372576
Hepatic failure 96.55 13.99 50 246881 38050 42336354
Eosinophilia 96.33 13.99 35 246896 32864 42341540
Blood urea increased 95.83 13.99 35 246896 32758 42341646
Ventricular tachycardia 95.51 13.99 28 246903 30132 42344272
Tachypnoea 95.51 13.99 8 246923 21654 42352750
Abnormal behaviour 94.62 13.99 19 246912 26432 42347972
Shock 94.13 13.99 26 246905 29095 42345309
White blood cell count decreased 94.09 13.99 326 246605 110070 42264334
Dyspnoea exertional 93.98 13.99 91 246840 50057 42324347
Pulmonary oedema 93.79 13.99 102 246829 53170 42321234
Injection site injury 93.22 13.99 45 246886 333 42374071
Troponin increased 93.19 13.99 4 246927 19058 42355346
Hallucination, visual 92.03 13.99 8 246923 21012 42353392
Heart rate decreased 91.01 13.99 49 246882 36483 42337921
Erythema 90.75 13.99 997 245934 107796 42266608
Intentional product use issue 90.56 13.99 174 246757 71659 42302745
Anaphylactic reaction 90.53 13.99 69 246862 42674 42331730
Generalised tonic-clonic seizure 90.18 13.99 21 246910 26358 42348046
Haematocrit decreased 89.67 13.99 45 246886 34863 42339541
Dislocation of vertebra 89.53 13.99 46 246885 395 42374009
Alanine aminotransferase abnormal 89.31 13.99 126 246805 4818 42369586
Nail disorder 88.71 13.99 87 246844 2240 42372164
Blood lactate dehydrogenase increased 88.70 13.99 21 246910 26060 42348344
Tenosynovitis 88.31 13.99 122 246809 4573 42369831
Pharyngitis streptococcal 88.30 13.99 111 246820 3789 42370615
Blood alkaline phosphatase increased 88.29 13.99 42 246889 33555 42340849
Acne cystic 88.20 13.99 50 246881 532 42373872
Angioedema 88.15 13.99 70 246861 42407 42331997
Cognitive disorder 87.85 13.99 44 246887 34128 42340276
Prostate cancer 87.68 13.99 499 246432 44144 42330260
Sinus tachycardia 87.39 13.99 9 246922 20644 42353760
Coronary artery disease 86.91 13.99 110 246821 53610 42320794
Accidental overdose 86.65 13.99 28 246903 28302 42346102
Pancreatitis acute 86.62 13.99 43 246888 33521 42340883
Medication error 86.28 13.99 42 246889 33112 42341292
Dyskinesia 85.25 13.99 21 246910 25369 42349035
Treatment noncompliance 84.78 13.99 57 246874 37615 42336789
Circulatory collapse 84.50 13.99 17 246914 23619 42350785
Exostosis 83.75 13.99 131 246800 5500 42368904
Drug eruption 83.64 13.99 309 246622 22766 42351638
Respiratory arrest 83.63 13.99 30 246901 28394 42346010
Hypothyroidism 82.95 13.99 41 246890 32043 42342361
Wrist deformity 82.78 13.99 41 246890 323 42374081
Skin haemorrhage 82.53 13.99 157 246774 7728 42366676
Subdural haematoma 81.98 13.99 17 246914 23121 42351283
Disorientation 81.97 13.99 55 246876 36334 42338070
Joint ankylosis 81.93 13.99 72 246859 1605 42372799
Leukocytosis 81.41 13.99 35 246896 29673 42344731
Renal failure 80.99 13.99 494 246437 143232 42231172
Sensitivity to weather change 80.92 13.99 78 246853 1965 42372439
Restlessness 80.88 13.99 34 246897 29215 42345189
Immune system disorder 80.87 13.99 134 246797 5910 42368494
Renal tubular necrosis 80.31 13.99 7 246924 18347 42356057
Palpitations 80.13 13.99 106 246825 50691 42323713
Injection site inflammation 79.67 13.99 60 246871 1066 42373338
Hepatic cytolysis 79.55 13.99 28 246903 26816 42347588
Extra dose administered 78.98 13.99 128 246803 5541 42368863
Device use error 78.85 13.99 95 246836 3102 42371302
Intervertebral disc protrusion 78.33 13.99 188 246743 10884 42363520
Acute respiratory failure 78.20 13.99 66 246865 38792 42335612
Onychoclasis 77.49 13.99 86 246845 2566 42371838
Spinal pain 77.20 13.99 140 246791 6642 42367762
Rectal haemorrhage 76.74 13.99 105 246826 49501 42324903
Clostridium difficile colitis 76.57 13.99 15 246916 21237 42353167
Full blood count abnormal 76.01 13.99 39 246892 29837 42344567
Chondrolysis 75.73 13.99 28 246903 94 42374310
Fibromyalgia 75.59 13.99 103 246828 3810 42370594
Hyperbilirubinaemia 75.55 13.99 14 246917 20621 42353783
Mineral metabolism disorder 75.24 13.99 40 246891 371 42374033
Nerve compression 74.76 13.99 104 246827 3924 42370480
Gait inability 74.74 13.99 296 246635 22537 42351867
Gamma-glutamyltransferase increased 74.71 13.99 48 246883 32449 42341955
Intervertebral disc space narrowing 74.40 13.99 58 246873 1087 42373317
Anaphylactic shock 74.16 13.99 22 246909 23495 42350909
Obstructive airways disorder 73.07 13.99 26 246905 24733 42349671
Sinus bradycardia 73.00 13.99 3 246928 14850 42359554
Acute respiratory distress syndrome 72.67 13.99 42 246889 30066 42344338
Pulmonary hypertension 72.61 13.99 23 246908 23546 42350858
Atlantoaxial instability 72.59 13.99 40 246891 401 42374003
Activated partial thromboplastin time prolonged 72.58 13.99 5 246926 15898 42358506
Arrhythmia 72.30 13.99 76 246855 40241 42334163
Drug-induced liver injury 72.24 13.99 69 246862 38204 42336200
Tooth disorder 71.79 13.99 191 246740 11788 42362616
Jaundice 71.77 13.99 57 246874 34532 42339872
Dizziness 71.58 13.99 1015 245916 248239 42126165
Drug tolerance decreased 71.50 13.99 78 246853 2282 42372122
Tooth extraction 71.32 13.99 120 246811 5360 42369044
Myocarditis 71.18 13.99 12 246919 18926 42355478
Adrenal insufficiency 71.11 13.99 12 246919 18912 42355492
Joint fluid drainage 70.80 13.99 27 246904 101 42374303
Myoclonus 70.77 13.99 8 246923 17057 42357347
Skin discolouration 70.15 13.99 273 246658 20617 42353787
Nightmare 69.28 13.99 29 246902 24983 42349421
Injection site paraesthesia 69.11 13.99 29 246902 147 42374257
Corrective lens user 69.03 13.99 23 246908 51 42374353
Tenderness 68.49 13.99 156 246775 8727 42365677
Small intestinal obstruction 68.29 13.99 9 246922 17052 42357352
Off label use 68.16 13.99 3016 243915 635319 41739085
Joint warmth 68.12 13.99 44 246887 603 42373801
Tremor 67.51 13.99 310 246621 96619 42277785
Osteonecrosis of jaw 67.48 13.99 14 246917 19035 42355369
Full blood count decreased 67.12 13.99 18 246913 20542 42353862
Malignant melanoma 66.92 13.99 160 246771 9240 42365164
Upper respiratory tract congestion 66.09 13.99 51 246880 941 42373463
Intentional self-injury 65.97 13.99 6 246925 15196 42359208
Pallor 65.95 13.99 43 246888 28843 42345561
Pulmonary thrombosis 65.91 13.99 148 246783 8200 42366204
End stage renal disease 65.65 13.99 9 246922 16549 42357855
Scratch 65.56 13.99 113 246818 5148 42369256
Increased tendency to bruise 65.46 13.99 102 246829 4268 42370136
Oral surgery 65.25 13.99 42 246889 572 42373832
Cyanosis 65.05 13.99 6 246925 15025 42359379
Latent tuberculosis 64.88 13.99 63 246868 1602 42372802
Neutropenic sepsis 64.83 13.99 8 246923 15938 42358466
Gastric disorder 64.40 13.99 183 246748 11739 42362665
Haemorrhage intracranial 64.38 13.99 11 246920 17181 42357223
Stevens-Johnson syndrome 64.25 13.99 24 246907 22154 42352250
Rotator cuff repair 64.16 13.99 36 246895 375 42374029
Shock haemorrhagic 63.99 13.99 9 246922 16233 42358171
Aspartate aminotransferase increased 63.63 13.99 231 246700 76932 42297472
Lung neoplasm malignant 63.30 13.99 249 246682 18898 42355506
Skin ulcer 63.25 13.99 305 246626 25296 42349108
Terminal state 63.16 13.99 101 246830 4322 42370082
Nephropathy toxic 62.56 13.99 11 246920 16827 42357577
Antibiotic therapy 62.09 13.99 24 246907 94 42374310
Fluid retention 62.05 13.99 55 246876 31564 42342840
Rheumatoid factor increased 61.71 13.99 43 246888 673 42373731
Acute hepatic failure 61.62 13.99 12 246919 17061 42357343
Aspiration 61.62 13.99 14 246917 17872 42356532
COVID-19 pneumonia 61.59 13.99 24 246907 21589 42352815
Hallucination, auditory 61.56 13.99 7 246924 14857 42359547
Therapeutic response delayed 61.55 13.99 43 246888 676 42373728
Cerebral infarction 61.43 13.99 54 246877 31115 42343289
Spinal instability 60.42 13.99 40 246891 573 42373831
Hypophagia 60.37 13.99 41 246890 26915 42347489
Ileus 60.18 13.99 18 246913 19121 42355283
Skin disorder 59.82 13.99 225 246706 16719 42357685
Lymphopenia 59.73 13.99 25 246906 21538 42352866
Electrolyte imbalance 59.69 13.99 13 246918 17088 42357316
Limb operation 59.46 13.99 48 246883 948 42373456
Dermatitis atopic 59.35 13.99 3 246928 12401 42362003
Coagulopathy 59.32 13.99 27 246904 22135 42352269
Intestinal obstruction 58.59 13.99 43 246888 27115 42347289
C-reactive protein increased 58.36 13.99 594 246337 62966 42311438
Epilepsy 58.35 13.99 40 246891 26131 42348273
Status epilepticus 58.27 13.99 10 246921 15568 42358836
Chest pain 58.24 13.99 522 246409 139008 42235396
Blood sodium decreased 57.25 13.99 17 246914 18145 42356259
Haemodynamic instability 57.16 13.99 4 246927 12553 42361851
Pneumonia 56.85 13.99 1940 244991 420209 41954195
Meniscus injury 56.83 13.99 71 246860 2408 42371996
Chronic obstructive pulmonary disease 56.75 13.99 182 246749 62932 42311472
Urinary tract infection 56.03 13.99 341 246590 98943 42275461
Posterior reversible encephalopathy syndrome 55.80 13.99 5 246926 12816 42361588
Haematochezia 55.75 13.99 164 246767 58272 42316132
Rotator cuff syndrome 55.67 13.99 120 246811 6466 42367938
Tooth loss 55.45 13.99 92 246839 4062 42370342
Skin exfoliation 55.11 13.99 421 246510 41132 42333272
Staphylococcal infection 54.83 13.99 390 246541 37253 42337151
Transplant rejection 54.79 13.99 7 246924 13581 42360823
Neutrophil count increased 54.79 13.99 23 246908 19781 42354623
Neoplasm malignant 54.79 13.99 269 246662 22474 42351930
Blood pressure systolic increased 54.46 13.99 49 246882 27919 42346485
Hepatic encephalopathy 54.43 13.99 14 246917 16428 42357976
Blood phosphorus increased 54.20 13.99 5 246926 12520 42361884
Hypothermia 54.15 13.99 5 246926 12510 42361894
Pathogen resistance 54.06 13.99 3 246928 11447 42362957
Rheumatoid factor positive 54.02 13.99 42 246889 784 42373620
Brain oedema 53.86 13.99 14 246917 16313 42358091
Prescribed overdose 53.76 13.99 6 246925 12921 42361483
Impaired quality of life 53.25 13.99 9 246922 14168 42360236
Endodontic procedure 53.02 13.99 36 246895 539 42373865
Presyncope 52.94 13.99 32 246899 22355 42352049
Pancreatitis 52.63 13.99 107 246824 43161 42331243
Back disorder 52.52 13.99 127 246804 7387 42367017
Cytomegalovirus infection 52.40 13.99 66 246865 32240 42342164
Anxiety 52.39 13.99 437 246494 118123 42256281
Cardiac operation 52.25 13.99 84 246847 3611 42370793
Aphasia 52.12 13.99 38 246893 24045 42350359
Vein rupture 51.82 13.99 44 246887 935 42373469
Cyst 51.75 13.99 103 246828 5243 42369161
Muscle rigidity 51.69 13.99 5 246926 12054 42362350
Anuria 51.56 13.99 4 246927 11528 42362876
Burning sensation 50.95 13.99 249 246682 20764 42353640
Face oedema 50.62 13.99 9 246922 13657 42360747
Skin mass 50.53 13.99 96 246835 4720 42369684
Blood potassium increased 50.53 13.99 22 246909 18514 42355890
Pustular psoriasis 50.45 13.99 62 246869 2067 42372337
Haematoma 50.05 13.99 53 246878 27970 42346434
Flushing 49.95 13.99 86 246845 36942 42337462
Hyperthyroidism 49.86 13.99 11 246920 14330 42360074
Delusion 49.83 13.99 12 246919 14722 42359682
Ankle deformity 49.73 13.99 25 246906 204 42374200
Cytology abnormal 49.42 13.99 30 246901 366 42374038
Venous injury 49.35 13.99 29 246902 332 42374072
Throat irritation 49.29 13.99 177 246754 12859 42361545
Cytopenia 48.92 13.99 20 246911 17477 42356927
Malnutrition 48.87 13.99 12 246919 14530 42359874
Intestinal sepsis 48.71 13.99 38 246893 713 42373691
Bacteraemia 48.60 13.99 44 246887 24996 42349408
Basal cell carcinoma 48.57 13.99 260 246671 22473 42351931
Physical disability 48.41 13.99 57 246874 1816 42372588
Hypogammaglobulinaemia 48.26 13.99 6 246925 11885 42362519
Ischaemic stroke 48.22 13.99 35 246896 22198 42352206
Muscle spasms 48.21 13.99 733 246198 85311 42289093
Device failure 48.21 13.99 69 246862 2674 42371730
Atrioventricular block complete 47.96 13.99 5 246926 11359 42363045
Red blood cell count decreased 47.88 13.99 72 246859 32643 42341761
Atrial flutter 47.78 13.99 20 246911 17231 42357173
Speech disorder 47.75 13.99 59 246872 29062 42345342
Incorrect disposal of product 47.66 13.99 30 246901 392 42374012
Ataxia 47.47 13.99 17 246914 16108 42358296
Frequent bowel movements 47.35 13.99 33 246898 21374 42353030
Post procedural infection 47.29 13.99 104 246827 5681 42368723
Electrocardiogram abnormal 46.86 13.99 3 246928 10142 42364262
Neck surgery 46.74 13.99 32 246899 486 42373918
Hypoalbuminaemia 46.74 13.99 16 246915 15594 42358810
Bronchospasm 46.62 13.99 9 246922 12876 42361528
Disseminated intravascular coagulation 46.44 13.99 45 246886 24749 42349655
Lyme disease 46.16 13.99 45 246886 1150 42373254
Asthma 45.97 13.99 195 246736 62119 42312285
Skin injury 45.78 13.99 66 246865 2575 42371829
Renal injury 45.67 13.99 8 246923 12272 42362132
Nephrolithiasis 45.45 13.99 367 246564 36463 42337941
Hernia repair 45.37 13.99 48 246883 1355 42373049
Klebsiella infection 45.31 13.99 6 246925 11326 42363078
Sudden death 44.91 13.99 20 246911 16609 42357795
Subarachnoid haemorrhage 44.80 13.99 14 246917 14458 42359946
Tooth abscess 44.77 13.99 112 246819 6656 42367748
Acne 44.75 13.99 177 246754 13467 42360937
Urinary incontinence 44.59 13.99 36 246895 21632 42352772
Prostate infection 44.36 13.99 46 246885 1268 42373136
Hepatocellular injury 44.32 13.99 43 246888 23635 42350769
Pulmonary arterial hypertension 44.26 13.99 4 246927 10183 42364221
Tricuspid valve incompetence 44.15 13.99 6 246925 11107 42363297
Hyperlipidaemia 43.96 13.99 36 246895 21480 42352924
Clostridium difficile infection 43.76 13.99 40 246891 22619 42351785
Hepatic enzyme increased 43.53 13.99 431 246500 45353 42329051
Drug specific antibody present 43.46 13.99 81 246850 3925 42370479
Acute coronary syndrome 43.20 13.99 16 246915 14849 42359555
Hypertension 43.09 13.99 695 246236 166509 42207895
Blood potassium decreased 43.04 13.99 33 246898 20351 42354053
Irritability 43.03 13.99 60 246871 28068 42346336
Urine output decreased 42.89 13.99 6 246925 10867 42363537
Thrombotic microangiopathy 42.81 13.99 16 246915 14766 42359638
Alopecia 42.45 13.99 303 246628 28973 42345431
Balance disorder 42.40 13.99 138 246793 47507 42326897
Arteriosclerosis coronary artery 42.37 13.99 28 246903 18649 42355755
Hepatitis cholestatic 42.30 13.99 4 246927 9820 42364584
Urosepsis 42.27 13.99 17 246914 15003 42359401
Dental implantation 42.04 13.99 17 246914 77 42374327
Angina pectoris 42.04 13.99 79 246852 32817 42341587
Respiratory symptom 41.82 13.99 7 246924 11099 42363305
Hip surgery 41.62 13.99 45 246886 1303 42373101
Proteinuria 41.57 13.99 43 246888 22940 42351464
Elbow operation 41.54 13.99 20 246911 147 42374257
Transient ischaemic attack 41.40 13.99 83 246848 33656 42340748
Lipase increased 41.29 13.99 6 246925 10560 42363844
Arthrodesis 41.20 13.99 31 246900 550 42373854
Mania 41.19 13.99 6 246925 10541 42363863
Myocardial ischaemia 41.15 13.99 26 246905 17736 42356668
Sacroiliitis 41.09 13.99 54 246877 1928 42372476
Cardiomegaly 41.01 13.99 23 246908 16743 42357661
Rash papular 41.00 13.99 156 246775 11655 42362749
Right ventricular failure 40.85 13.99 4 246927 9551 42364853
Viral upper respiratory tract infection 40.72 13.99 69 246862 3100 42371304
Scab 40.71 13.99 99 246832 5779 42368625
Product prescribing error 40.65 13.99 55 246876 26057 42348347
Blood pressure fluctuation 40.57 13.99 58 246873 26850 42347554
White blood cell count increased 40.54 13.99 130 246801 44957 42329447
Bronchopulmonary aspergillosis 40.33 13.99 32 246899 19397 42355007
Oesophagitis 40.15 13.99 19 246912 15228 42359176
Substance abuse 40.06 13.99 3 246928 8902 42365502
Mitral valve incompetence 39.79 13.99 23 246908 16466 42357938
Myopathy 39.68 13.99 15 246916 13746 42360658
Left ventricular dysfunction 39.62 13.99 9 246922 11492 42362912
Oliguria 39.55 13.99 4 246927 9309 42365095
Parkinsonism 39.33 13.99 7 246924 10616 42363788
Paranoia 39.27 13.99 16 246915 14010 42360394
Road traffic accident 39.19 13.99 216 246715 18877 42355527
Inappropriate schedule of product administration 38.96 13.99 776 246155 95126 42279278
Feeling hot 38.80 13.99 251 246680 23231 42351173
Hypovolaemic shock 38.72 13.99 3 246928 8656 42365748
Cardiac failure chronic 38.58 13.99 5 246926 9596 42364808
Dental operation 38.51 13.99 27 246904 427 42373977
Second primary malignancy 38.45 13.99 5 246926 9570 42364834
Acute generalised exanthematous pustulosis 38.37 13.99 3 246928 8592 42365812
Bronchiectasis 38.26 13.99 29 246902 17990 42356414
Ependymoma malignant 38.23 13.99 12 246919 20 42374384
Meniscus operation 38.16 13.99 11 246920 11 42374393
Arteriosclerosis 38.14 13.99 29 246902 17960 42356444
Rheumatoid lung 37.96 13.99 36 246895 888 42373516
Neck mass 37.73 13.99 50 246881 1800 42372604
Spondylitis 37.70 13.99 46 246885 1522 42372882
Amyotrophic lateral sclerosis 37.67 13.99 39 246892 1073 42373331
Hyperuricaemia 37.65 13.99 5 246926 9419 42364985
Atelectasis 37.60 13.99 34 246897 19327 42355077
Osteosclerosis 37.60 13.99 45 246886 1459 42372945
Prescribed underdose 37.59 13.99 7 246924 10275 42364129
Polyarthritis 37.55 13.99 88 246843 5016 42369388
Ankle operation 37.51 13.99 23 246908 286 42374118
Injection site nodule 37.45 13.99 54 246877 2107 42372297
Rash pruritic 37.30 13.99 327 246604 33276 42341128
Lupus-like syndrome 37.04 13.99 66 246865 3088 42371316
Myasthenia gravis 36.87 13.99 24 246907 16113 42358291
Appendicitis 36.79 13.99 39 246892 20574 42353830
Pulmonary alveolar haemorrhage 36.71 13.99 20 246911 14796 42359608
Acute myeloid leukaemia 36.59 13.99 45 246886 22211 42352193
Limb crushing injury 36.57 13.99 15 246916 71 42374333
Hepatotoxicity 36.24 13.99 56 246875 25111 42349293
Chills 36.19 13.99 359 246572 93707 42280697
Cerebrovascular accident 36.07 13.99 374 246557 96786 42277618
Purpura 35.87 13.99 12 246919 11867 42362537
Trigger finger 35.83 13.99 37 246894 1015 42373389
Device related infection 35.49 13.99 39 246892 20240 42354164
Disturbance in attention 35.35 13.99 75 246856 29791 42344613
Failure to thrive 35.34 13.99 6 246925 9416 42364988
Squamous cell carcinoma 35.25 13.99 159 246772 12823 42361581
Eye operation 35.20 13.99 28 246903 541 42373863
Breath sounds abnormal 35.17 13.99 13 246918 12080 42362324
Intestinal ischaemia 35.17 13.99 6 246925 9382 42365022
Withdrawal syndrome 35.10 13.99 21 246910 14754 42359650
Accident at work 34.91 13.99 35 246896 926 42373478
Toe operation 34.87 13.99 14 246917 62 42374342
Toxic skin eruption 34.81 13.99 18 246913 13712 42360692
Limb deformity 34.77 13.99 28 246903 551 42373853
Nail pitting 34.73 13.99 25 246906 413 42373991
Polychondritis 34.69 13.99 24 246907 371 42374033
Hypopnoea 34.50 13.99 3 246928 7879 42366525
Arthropod sting 34.47 13.99 26 246905 463 42373941
Pulmonary sarcoidosis 34.46 13.99 32 246899 768 42373636
Rash erythematous 34.44 13.99 310 246621 31781 42342623
Blood uric acid increased 34.34 13.99 24 246907 15523 42358881
Hypertransaminasaemia 34.34 13.99 6 246925 9221 42365183
Drug resistance 34.22 13.99 94 246837 34154 42340250
Polyuria 34.16 13.99 8 246923 10003 42364401
Hyperthermia 34.15 13.99 15 246916 12559 42361845
Gallbladder operation 34.02 13.99 28 246903 569 42373835
Pulmonary embolism 33.93 13.99 488 246443 119124 42255280
Blood calcium decreased 33.93 13.99 11 246920 11097 42363307
Hiccups 33.89 13.99 14 246917 12157 42362247
Low birth weight baby 33.88 13.99 8 246923 9947 42364457
Artificial crown procedure 33.75 13.99 10 246921 12 42374392
Iron deficiency 33.70 13.99 11 246920 11050 42363354
Stent placement 33.69 13.99 87 246844 5273 42369131
Arthritis bacterial 33.59 13.99 92 246839 5776 42368628
Paranasal sinus discomfort 33.58 13.99 38 246893 1159 42373245
Hypercalcaemia 33.56 13.99 33 246898 18025 42356379
Body temperature decreased 33.52 13.99 21 246910 14392 42360012
Haemodialysis 33.46 13.99 9 246922 10251 42364153
Prothrombin time prolonged 33.45 13.99 7 246924 9462 42364942
Injection site hypersensitivity 33.16 13.99 24 246907 400 42374004
Toothache 33.08 13.99 108 246823 7475 42366929
Alanine aminotransferase increased 32.94 13.99 340 246591 88066 42286338
Transfusion 32.85 13.99 10 246921 10504 42363900
Alcohol poisoning 32.84 13.99 3 246928 7571 42366833
Rash macular 32.62 13.99 188 246743 16703 42357701
Drug ineffective for unapproved indication 32.50 13.99 147 246784 46016 42328388
Ingrown hair 32.45 13.99 18 246913 183 42374221
Gastroenteritis viral 32.44 13.99 113 246818 8086 42366318
Infected bite 32.41 13.99 25 246906 461 42373943
Candida infection 32.16 13.99 47 246884 21563 42352841
Respiratory rate increased 31.99 13.99 12 246919 11050 42363354
Asphyxia 31.91 13.99 5 246926 8321 42366083
Swollen tongue 31.77 13.99 46 246885 21185 42353219
Hepatic enzyme abnormal 31.76 13.99 66 246865 3466 42370938
Intestinal polyp 31.67 13.99 39 246892 1303 42373101
Injection site coldness 31.43 13.99 11 246920 30 42374374
Glomerular filtration rate decreased 31.41 13.99 29 246902 16322 42358082
Liver injury 31.18 13.99 39 246892 19109 42355295
Osteolysis 31.14 13.99 66 246865 3514 42370890
Medical device implantation 31.02 13.99 27 246904 594 42373810
Cataract operation 30.89 13.99 40 246891 1407 42372997
Pseudomonas infection 30.88 13.99 28 246903 15895 42358509
Carpal tunnel syndrome 30.87 13.99 86 246845 5453 42368951
Bundle branch block right 30.77 13.99 5 246926 8101 42366303
Product use issue 30.76 13.99 290 246641 76461 42297943
Left ventricular hypertrophy 30.72 13.99 8 246923 9311 42365093
Dysstasia 30.70 13.99 162 246769 13924 42360480
Anhedonia 30.65 13.99 4 246927 7636 42366768
Product quality issue 30.63 13.99 35 246896 17847 42356557
Intentional dose omission 30.63 13.99 118 246813 8868 42365536
Eye disorder 30.62 13.99 141 246790 11471 42362933
Blood pressure diastolic decreased 30.43 13.99 11 246920 10364 42364040
Pulmonary haemorrhage 30.32 13.99 14 246917 11383 42363021
Eczema 30.14 13.99 99 246832 33987 42340417
Hepatitis B virus test positive 30.12 13.99 21 246910 329 42374075
Duodenal ulcer 29.81 13.99 17 246914 12262 42362142
Nail bed disorder 29.76 13.99 10 246921 23 42374381
Drug dependence 29.71 13.99 79 246852 29015 42345389
Dental caries 29.52 13.99 78 246853 4794 42369610
Pericardial effusion 29.51 13.99 80 246851 29195 42345209
Nail psoriasis 29.47 13.99 15 246916 126 42374278
Joint injury 29.43 13.99 165 246766 14511 42359893
Haemorrhagic stroke 29.40 13.99 4 246927 7398 42367006
Thymoma benign 29.39 13.99 12 246919 56 42374348
Arthritis infective 29.34 13.99 70 246861 4036 42370368
Ventricular hypokinesia 29.12 13.99 3 246928 6881 42367523
Nocturia 29.08 13.99 17 246914 12095 42362309
Injection site hypoaesthesia 28.98 13.99 15 246916 131 42374273
Episcleritis 28.97 13.99 17 246914 194 42374210
Cholangitis 28.81 13.99 13 246918 10714 42363690
Obsessive-compulsive disorder 28.37 13.99 3 246928 6740 42367664
Paraesthesia 28.37 13.99 590 246341 72869 42301535
Psychomotor hyperactivity 28.33 13.99 14 246917 10944 42363460
Gynaecomastia 28.29 13.99 19 246912 12548 42361856
Breast feeding 28.27 13.99 8 246923 7 42374397
Ear congestion 28.11 13.99 27 246904 677 42373727
Emotional distress 28.11 13.99 31 246900 16062 42358342
Glioblastoma 28.06 13.99 38 246893 1397 42373007
Taste disorder 28.00 13.99 12 246919 10195 42364209
Hypotonia 27.98 13.99 10 246921 9489 42364915
Tonsil cancer 27.82 13.99 34 246897 1127 42373277
Pemphigoid 27.66 13.99 16 246915 11451 42362953
Transaminases increased 27.39 13.99 98 246833 32787 42341617
Bursitis 27.30 13.99 89 246842 6155 42368249
Hepatitis acute 27.22 13.99 9 246922 8966 42365438
Apnoea 27.09 13.99 6 246925 7797 42366607
Dysgeusia 27.09 13.99 104 246827 34085 42340319
Macule 27.07 13.99 45 246886 1990 42372414
Toxic encephalopathy 27.05 13.99 4 246927 6949 42367455
Myelodysplastic syndrome 27.02 13.99 57 246874 22688 42351716
Sleep disorder due to a general medical condition 26.93 13.99 37 246894 17416 42356988
Peritonitis bacterial 26.85 13.99 4 246927 6911 42367493
Hospice care 26.77 13.99 8 246923 8505 42365899
Stomatitis 26.74 13.99 425 246506 49904 42324500
Intervertebral disc disorder 26.72 13.99 44 246887 1930 42372474
Benign prostatic hyperplasia 26.51 13.99 51 246880 21001 42353403
Oral herpes 26.48 13.99 100 246831 7444 42366960
Hepatitis 26.48 13.99 76 246855 27224 42347180
Device occlusion 26.47 13.99 8 246923 8442 42365962
Cardiac failure acute 26.40 13.99 24 246907 13609 42360795
Coordination abnormal 26.37 13.99 7 246924 8043 42366361
Gastric haemorrhage 26.34 13.99 14 246917 10501 42363903
Immune recovery uveitis 26.28 13.99 12 246919 77 42374327
Aplastic anaemia 26.21 13.99 20 246911 12364 42362040
Pruritus 26.19 13.99 1341 245590 187430 42186974
Respiratory acidosis 26.17 13.99 3 246928 6328 42368076
Decubitus ulcer 26.17 13.99 14 246917 10463 42363941
Aortic stenosis 26.12 13.99 9 246922 8736 42365668
Aplasia pure red cell 25.94 13.99 5 246926 7161 42367243
Body temperature increased 25.91 13.99 49 246882 20309 42354095
Anal incontinence 25.78 13.99 11 246920 9370 42365034
Prostatic operation 25.69 13.99 22 246909 473 42373931
Tongue disorder 25.62 13.99 79 246852 5304 42369100
Wrong product administered 25.61 13.99 3 246928 6223 42368181
Intervertebral disc operation 25.60 13.99 18 246913 286 42374118
Tendon disorder 25.55 13.99 59 246872 3330 42371074
Ventricular extrasystoles 25.43 13.99 24 246907 13366 42361038
Carpal tunnel decompression 25.41 13.99 17 246914 248 42374156
Behaviour disorder 25.37 13.99 5 246926 7049 42367355
Injection site hyperaesthesia 25.35 13.99 7 246924 5 42374399
Device dislocation 25.29 13.99 7 246924 7824 42366580
Ligament operation 25.24 13.99 8 246923 14 42374390
Discomfort 25.24 13.99 240 246691 24979 42349425
Iron deficiency anaemia 25.20 13.99 23 246908 13016 42361388
Exposure during pregnancy 25.18 13.99 9 246922 8539 42365865
Oedema peripheral 25.17 13.99 598 246333 135478 42238926
Cytomegalovirus infection reactivation 25.03 13.99 17 246914 11161 42363243
Tendon sheath incision 24.94 13.99 6 246925 0 42374404
Dactylitis 24.86 13.99 32 246899 1119 42373285
Angina unstable 24.85 13.99 18 246913 11430 42362974
Blood magnesium decreased 24.78 13.99 7 246924 7719 42366685
Glycosylated haemoglobin increased 24.73 13.99 23 246908 12901 42361503
Gastritis erosive 24.71 13.99 4 246927 6499 42367905
Colitis 24.69 13.99 163 246768 46409 42327995
Ankle fracture 24.65 13.99 73 246858 4793 42369611
Cutaneous sarcoidosis 24.61 13.99 14 246917 150 42374254
Eosinophil count increased 24.60 13.99 16 246915 10747 42363657
Hernia 24.58 13.99 128 246803 10945 42363459
Petechiae 24.55 13.99 15 246916 10420 42363984
Poor venous access 24.34 13.99 6 246925 7246 42367158
Herpes ophthalmic 24.32 13.99 25 246906 682 42373722
Lymphadenopathy 24.31 13.99 298 246633 33067 42341337
Meningitis viral 24.30 13.99 31 246900 1074 42373330
Injection site anaesthesia 24.29 13.99 7 246924 7 42374397
Gastroenteritis 24.26 13.99 36 246895 16413 42357991
Onychomadesis 24.23 13.99 25 246906 685 42373719
Cardiovascular disorder 24.17 13.99 25 246906 13340 42361064
Head injury 24.10 13.99 52 246879 20530 42353874
Hydronephrosis 24.05 13.99 20 246911 11845 42362559
Viral infection 24.03 13.99 217 246714 22266 42352138
Cartilage injury 23.97 13.99 23 246908 576 42373828
Malignant melanoma stage I 23.97 13.99 12 246919 97 42374307
Chest discomfort 23.96 13.99 244 246687 63372 42311032
Atrial septal defect 23.91 13.99 8 246923 7911 42366493
Food intolerance 23.90 13.99 38 246893 1618 42372786
Colitis ulcerative 23.85 13.99 75 246856 26100 42348304
Lower respiratory tract infection 23.83 13.99 353 246578 40853 42333551
Tendonitis 23.81 13.99 117 246814 9777 42364627
Propionibacterium infection 23.77 13.99 16 246915 236 42374168
Haemolysis 23.68 13.99 13 246918 9576 42364828
Rocky mountain spotted fever 23.63 13.99 8 246923 19 42374385
Acute graft versus host disease 23.61 13.99 9 246922 8206 42366198
Peritonitis 23.58 13.99 45 246886 18588 42355816
Syringe issue 23.57 13.99 10 246921 8546 42365858
Hyperaesthesia teeth 23.55 13.99 23 246908 589 42373815
Methaemoglobinaemia 23.22 13.99 3 246928 5771 42368633
Ligament rupture 23.21 13.99 34 246897 1346 42373058
Periarthritis 23.21 13.99 34 246897 1346 42373058
Guttate psoriasis 23.16 13.99 22 246909 544 42373860
Erythrodermic psoriasis 23.15 13.99 30 246901 1056 42373348
Thyroid cancer 23.14 13.99 39 246892 1744 42372660
Skin cancer 23.07 13.99 129 246802 11333 42363071
Ageusia 22.99 13.99 20 246911 11585 42362819
Blood loss anaemia 22.90 13.99 14 246917 9722 42364682
Pulmonary fibrosis 22.89 13.99 246 246685 26435 42347969
Cystitis haemorrhagic 22.85 13.99 7 246924 7322 42367082
Muscle swelling 22.83 13.99 20 246911 444 42373960
Premature baby 22.79 13.99 64 246867 23089 42351315
Supraventricular tachycardia 22.68 13.99 23 246908 12385 42362019
Memory impairment 22.65 13.99 413 246518 49809 42324595
Ulcerative duodenitis 22.55 13.99 8 246923 23 42374381
Pneumonia bacterial 22.51 13.99 35 246896 15657 42358747
Wrist surgery 22.49 13.99 13 246918 144 42374260
Lethargy 22.47 13.99 169 246762 46721 42327683
Acute pulmonary oedema 22.44 13.99 11 246920 8640 42365764
Atrioventricular block 22.38 13.99 14 246917 9601 42364803
Cerebral haematoma 22.36 13.99 3 246928 5607 42368797
Euphoric mood 22.33 13.99 5 246926 6448 42367956
Dermatitis contact 22.29 13.99 67 246864 4436 42369968
Pulmonary granuloma 22.19 13.99 37 246894 1640 42372764
Multiple sclerosis 22.10 13.99 95 246836 7503 42366901
Sunburn 21.99 13.99 42 246889 2073 42372331
Product prescribing issue 21.98 13.99 6 246925 6767 42367637
Lower limb fracture 21.90 13.99 71 246860 4896 42369508
False positive tuberculosis test 21.90 13.99 6 246925 4 42374400
Dermatitis psoriasiform 21.90 13.99 42 246889 2080 42372324
Cardiac murmur 21.88 13.99 25 246906 12750 42361654
Limb injury 21.88 13.99 150 246781 14155 42360249
Occupational exposure to product 21.83 13.99 19 246912 418 42373986
Exposure to communicable disease 21.79 13.99 14 246917 190 42374214
Amylase increased 21.76 13.99 6 246925 6723 42367681
Steroid dependence 21.73 13.99 6 246925 6716 42367688
Contraindication to medical treatment 21.51 13.99 26 246905 852 42373552
Partial seizures 21.39 13.99 4 246927 5855 42368549
T-cell type acute leukaemia 21.30 13.99 14 246917 198 42374206
Cardiomyopathy 21.30 13.99 50 246881 19160 42355244
Normochromic normocytic anaemia 21.22 13.99 13 246918 9018 42365386
Tendon pain 21.19 13.99 54 246877 3246 42371158
Tooth impacted 21.18 13.99 10 246921 70 42374334
Injection site laceration 21.17 13.99 8 246923 29 42374375
Pneumocystis jirovecii pneumonia 21.00 13.99 75 246856 25106 42349298
Lower gastrointestinal haemorrhage 20.96 13.99 19 246912 10789 42363615
Increased upper airway secretion 20.95 13.99 46 246885 2510 42371894
Rheumatoid factor 20.94 13.99 10 246921 72 42374332
Retinal haemorrhage 20.94 13.99 4 246927 5766 42368638
Liver function test increased 20.85 13.99 192 246739 19806 42354598
Whipple's disease 20.82 13.99 6 246925 6 42374398
Tuberculin test 20.78 13.99 5 246926 0 42374404
Hangnail 20.78 13.99 5 246926 0 42374404
Chromaturia 20.78 13.99 38 246893 15951 42358453
Gastric ulcer haemorrhage 20.70 13.99 5 246926 6122 42368282
Pathological fracture 20.69 13.99 3 246928 5290 42369114
Nasal cavity cancer 20.65 13.99 14 246917 209 42374195
Colitis ischaemic 20.63 13.99 8 246923 7218 42367186
Obesity 20.61 13.99 40 246891 16419 42357985
Spinal disorder 20.58 13.99 66 246865 4525 42369879
Bundle branch block left 20.52 13.99 6 246925 6470 42367934
Diabetes mellitus inadequate control 20.52 13.99 36 246895 15354 42359050
Limb mass 20.49 13.99 25 246906 827 42373577
Incontinence 20.45 13.99 7 246924 6823 42367581
Seronegative arthritis 20.36 13.99 30 246901 1194 42373210
Graft versus host disease 20.35 13.99 27 246904 12898 42361506
Systemic infection 20.23 13.99 3 246928 5202 42369202
Skin fissures 20.21 13.99 110 246821 9566 42364838
Dysuria 20.15 13.99 102 246829 30994 42343410
Blood calcium increased 20.10 13.99 12 246919 8442 42365962
Embolism 20.06 13.99 13 246918 8750 42365654
Neurological symptom 20.06 13.99 17 246914 9974 42364430
Pulseless electrical activity 20.03 13.99 12 246919 8425 42365979
Proctalgia 20.01 13.99 8 246923 7085 42367319
Seminoma 19.99 13.99 16 246915 312 42374092
Protein total decreased 19.95 13.99 5 246926 5971 42368433
Cervical vertebral fracture 19.91 13.99 43 246888 2320 42372084
Foetal heart rate decreased 19.81 13.99 9 246922 57 42374347
Rebound effect 19.73 13.99 9 246922 7370 42367034
Bladder transitional cell carcinoma recurrent 19.71 13.99 13 246918 185 42374219
Infected cyst 19.68 13.99 20 246911 538 42373866
Product dose omission in error 19.67 13.99 12 246919 8342 42366062
Micturition urgency 19.62 13.99 24 246907 11874 42362530
Erectile dysfunction 19.60 13.99 76 246855 24837 42349567
Neutrophilia 19.53 13.99 4 246927 5488 42368916
Joint surgery 19.50 13.99 6 246925 9 42374395
Bacterial infection 19.49 13.99 89 246842 27790 42346614
Mouth haemorrhage 19.48 13.99 6 246925 6255 42368149
Brain injury 19.46 13.99 10 246921 7645 42366759
Hemiparesis 19.44 13.99 45 246886 17331 42357073
Hospitalisation 19.44 13.99 308 246623 74022 42300382
Haemolytic anaemia 19.43 13.99 25 246906 12102 42362302
Metastases to bone 19.42 13.99 35 246896 14774 42359630
Ischaemia 19.41 13.99 3 246928 5044 42369360
Ileus paralytic 19.39 13.99 10 246921 7631 42366773
Haemorrhoids 19.36 13.99 44 246887 17053 42357351
Device dispensing error 19.35 13.99 10 246921 87 42374317
Cyst removal 19.32 13.99 8 246923 39 42374365
Lung opacity 19.26 13.99 5 246926 5832 42368572
Hyperhidrosis 19.25 13.99 389 246542 90123 42284281
Nephropathy 19.16 13.99 8 246923 6903 42367501
Immune thrombocytopenia 19.16 13.99 22 246909 11194 42363210
Spinal fusion acquired 19.15 13.99 8 246923 40 42374364
Duodenal ulcer haemorrhage 19.12 13.99 5 246926 5803 42368601
Nail bed bleeding 19.12 13.99 18 246913 440 42373964
Enterococcal infection 19.10 13.99 25 246906 12014 42362390
Fibrin D dimer increased 19.09 13.99 3 246928 4982 42369422
Scar 18.98 13.99 83 246848 6605 42367799
Immunosuppression 18.96 13.99 98 246833 8355 42366049
Ear neoplasm 18.94 13.99 9 246922 64 42374340
Nail infection 18.92 13.99 16 246915 338 42374066
General symptom 18.91 13.99 27 246904 1044 42373360
Dialysis 18.91 13.99 25 246906 11961 42362443
Rubber sensitivity 18.90 13.99 17 246914 391 42374013
B-cell lymphoma 18.82 13.99 67 246864 4846 42369558
Prostatic specific antigen increased 18.80 13.99 44 246887 16881 42357523
Peripheral sensory neuropathy 18.73 13.99 14 246917 8748 42365656
Generalised oedema 18.58 13.99 38 246893 15298 42359106
Blood thyroid stimulating hormone increased 18.52 13.99 4 246927 5288 42369116
Eosinophilic pneumonia 18.51 13.99 3 246928 4871 42369533
Post procedural haemorrhage 18.51 13.99 16 246915 9296 42365108
Hepatic cirrhosis 18.49 13.99 185 246746 19517 42354887
Weight increased 18.48 13.99 480 246451 107503 42266901
Expired device used 18.42 13.99 12 246919 167 42374237
Heart rate irregular 18.42 13.99 41 246890 16009 42358395
Bradyphrenia 18.36 13.99 4 246927 5258 42369146
Adverse drug reaction 18.36 13.99 312 246619 37122 42337282
Blood glucose decreased 18.30 13.99 34 246897 14185 42360219
Frustration tolerance decreased 18.30 13.99 51 246880 3235 42371169
Faeces discoloured 18.29 13.99 45 246886 16969 42357435
Brain herniation 18.25 13.99 3 246928 4820 42369584
Ventricular hypertrophy 18.21 13.99 3 246928 4813 42369591
Product complaint 18.11 13.99 6 246925 5971 42368433
Complication associated with device 18.10 13.99 8 246923 6673 42367731
Pulse absent 18.07 13.99 7 246924 6320 42368084
C-reactive protein decreased 18.05 13.99 40 246891 2196 42372208
Fine motor skill dysfunction 18.02 13.99 40 246891 2199 42372205
Weight fluctuation 17.99 13.99 6 246925 5945 42368459
Precancerous skin lesion 17.93 13.99 20 246911 600 42373804
Antinuclear antibody positive 17.91 13.99 33 246898 1585 42372819
Extranodal marginal zone B-cell lymphoma (MALT type) 17.89 13.99 15 246916 313 42374091
Cholecystitis acute 17.80 13.99 11 246920 7595 42366809
Escherichia bacteraemia 17.80 13.99 4 246927 5145 42369259
Rales 17.76 13.99 24 246907 11376 42363028
Gastritis 17.61 13.99 75 246856 23872 42350532
Photosensitivity reaction 17.57 13.99 130 246801 12572 42361832
Neuritis 17.57 13.99 7 246924 6213 42368191
Vascular graft 17.56 13.99 32 246899 1524 42372880
X-ray abnormal 17.42 13.99 18 246913 494 42373910
Retroperitoneal fibrosis 17.42 13.99 17 246914 435 42373969
Skin lesion 17.39 13.99 237 246694 26937 42347467
Yolk sac tumour site unspecified 17.35 13.99 5 246926 5 42374399
Superficial spreading melanoma stage unspecified 17.31 13.99 13 246918 230 42374174
Drug tolerance 17.28 13.99 50 246881 3240 42371164
Mite allergy 17.28 13.99 4 246927 5042 42369362
Injection site pustule 17.24 13.99 6 246925 16 42374388
Penile squamous cell carcinoma 17.16 13.99 9 246922 81 42374323
Hypertriglyceridaemia 17.15 13.99 20 246911 10106 42364298
Ligament disorder 17.14 13.99 11 246920 149 42374255
Lip and/or oral cavity cancer 17.10 13.99 17 246914 445 42373959
Spinal stenosis 17.05 13.99 78 246853 6328 42368076
Myositis 17.04 13.99 38 246893 14828 42359576
Granuloma skin 17.01 13.99 27 246904 1148 42373256
Pain of skin 16.98 13.99 92 246839 7988 42366416
International normalised ratio decreased 16.96 13.99 3 246928 4569 42369835
Septic arthritis staphylococcal 16.93 13.99 18 246913 511 42373893
Bunion operation 16.88 13.99 5 246926 6 42374398
Walking aid user 16.82 13.99 43 246888 2590 42371814
HLA-B*27 positive 16.76 13.99 7 246924 35 42374369
Hyperlactacidaemia 16.67 13.99 3 246928 4513 42369891
Lung infiltration 16.66 13.99 35 246896 13954 42360450
Chronic graft versus host disease 16.66 13.99 7 246924 6018 42368386
Neonatal respiratory distress syndrome 16.65 13.99 3 246928 4510 42369894
Cast application 16.63 13.99 4 246927 0 42374404
Spinal laminectomy 16.61 13.99 15 246916 347 42374057
Muscle tightness 16.59 13.99 70 246861 5483 42368921
Flatulence 16.58 13.99 82 246849 25070 42349334
Lung consolidation 16.56 13.99 9 246922 6668 42367736
Axial spondyloarthritis 16.49 13.99 18 246913 527 42373877
Metabolic encephalopathy 16.46 13.99 5 246926 5260 42369144
Radiation inflammation 16.45 13.99 25 246906 1023 42373381
Red cell distribution width increased 16.40 13.99 10 246921 6954 42367450
Xyphoid retraction 16.35 13.99 11 246920 162 42374242
Animal bite 16.30 13.99 22 246909 806 42373598
Manufacturing product shipping issue 16.29 13.99 7 246924 38 42374366
Intervertebral disc injury 16.26 13.99 6 246925 20 42374384
Eating disorder 16.23 13.99 20 246911 9865 42364539
Angioimmunoblastic T-cell lymphoma 16.22 13.99 15 246916 358 42374046
Intercepted product administration error 16.22 13.99 18 246913 537 42373867
Diaphragmatic injury 16.20 13.99 10 246921 126 42374278
Interstitial lung disease 16.15 13.99 339 246592 78123 42296281
Ear pain 16.08 13.99 76 246855 6250 42368154
Tonsillar disorder 16.06 13.99 16 246915 420 42373984
Gingival discolouration 16.05 13.99 5 246926 8 42374396
Head discomfort 16.05 13.99 66 246865 5111 42369293
Myelitis 16.03 13.99 25 246906 1047 42373357
Cachexia 16.01 13.99 14 246917 8090 42366314
Ischaemic cardiomyopathy 15.88 13.99 9 246922 6513 42367891
Product administered to patient of inappropriate age 15.86 13.99 4 246927 4757 42369647
Staphylococcal bacteraemia 15.77 13.99 25 246906 11096 42363308
Dermatitis acneiform 15.74 13.99 13 246918 7726 42366678
Tendon operation 15.74 13.99 8 246923 67 42374337
Abdominal discomfort 15.70 13.99 558 246373 74697 42299707
Oral infection 15.66 13.99 40 246891 2408 42371996
Insurance issue 15.66 13.99 56 246875 4060 42370344
Benign neoplasm of thyroid gland 15.62 13.99 6 246925 23 42374381
Cholecystectomy 15.58 13.99 49 246882 3325 42371079
Drooling 15.56 13.99 3 246928 4296 42370108
Depression 15.55 13.99 509 246422 110854 42263550
Gastric operation 15.54 13.99 9 246922 100 42374304
Liver function test abnormal 15.54 13.99 269 246662 32122 42342282
Mixed connective tissue disease 15.45 13.99 7 246924 44 42374360
Mycobacterial infection 15.44 13.99 42 246889 2626 42371778
Blood culture positive 15.44 13.99 5 246926 5048 42369356
Burns second degree 15.44 13.99 8 246923 6088 42368316
Intracranial pressure increased 15.43 13.99 4 246927 4670 42369734
Secretion discharge 15.42 13.99 86 246845 7549 42366855
Pulmonary tuberculosis 15.41 13.99 68 246863 5433 42368971
Gastric bypass 15.40 13.99 13 246918 274 42374130
Granuloma 15.39 13.99 55 246876 3986 42370418
Mental impairment 15.37 13.99 30 246901 12287 42362117
Progressive multifocal leukoencephalopathy 15.37 13.99 27 246904 11509 42362895
Occult blood positive 15.34 13.99 3 246928 4254 42370150
Pulmonary function test decreased 15.31 13.99 7 246924 5725 42368679
Polyneuropathy 15.28 13.99 56 246875 18605 42355799
Multiple-drug resistance 15.27 13.99 12 246919 7310 42367094
Papillary cystadenoma lymphomatosum 15.19 13.99 7 246924 46 42374358
Carbuncle 15.19 13.99 7 246924 46 42374358
Laryngeal cancer 15.11 13.99 20 246911 719 42373685
Body tinea 15.06 13.99 11 246920 186 42374218
Oesophageal infection 15.04 13.99 14 246917 337 42374067
Cerebral ischaemia 15.03 13.99 11 246920 6948 42367456
Systemic candida 15 13.99 6 246925 5313 42369091
Intestinal perforation 14.90 13.99 25 246906 10849 42363555
Nail discolouration 14.83 13.99 26 246905 1201 42373203
Portal vein thrombosis 14.82 13.99 4 246927 4545 42369859
Pulmonary pain 14.79 13.99 30 246901 1548 42372856
Faeces soft 14.76 13.99 5 246926 4907 42369497
Foot fracture 14.75 13.99 73 246858 6118 42368286
Echinococciasis 14.74 13.99 5 246926 12 42374392
Arthroscopic surgery 14.74 13.99 5 246926 12 42374392
Graft versus host disease in gastrointestinal tract 14.73 13.99 64 246867 5079 42369325
Arthroscopy 14.71 13.99 10 246921 150 42374254
Muscle haemorrhage 14.67 13.99 3 246928 4122 42370282
Immobile 14.60 13.99 43 246888 2815 42371589
Erythema multiforme 14.55 13.99 22 246909 9955 42364449
Hepatic steatosis 14.53 13.99 189 246742 21259 42353145
Red blood cell sedimentation rate 14.52 13.99 24 246907 1056 42373348
Muscle spasticity 14.46 13.99 11 246920 6811 42367593
Carbon dioxide abnormal 14.42 13.99 13 246918 300 42374104
Hypertensive crisis 14.42 13.99 23 246908 10183 42364221
Panniculitis 14.33 13.99 36 246895 2145 42372259
Bacterial sepsis 14.32 13.99 10 246921 6472 42367932
Oligoarthritis 14.30 13.99 11 246920 202 42374202
Synovial disorder 14.30 13.99 11 246920 202 42374202
Wisdom teeth removal 14.29 13.99 12 246919 251 42374153
Affect lability 14.26 13.99 3 246928 4041 42370363
Odynophagia 14.24 13.99 11 246920 6759 42367645
Orthosis user 14.19 13.99 5 246926 14 42374390
Metabolic disorder 14.17 13.99 5 246926 4783 42369621
Blood triglycerides increased 14.17 13.99 46 246885 15850 42358554
Bladder transitional cell carcinoma stage II 14.15 13.99 7 246924 55 42374349
Nasal discharge discolouration 14.05 13.99 15 246916 428 42373976
Reactive gastropathy 14.04 13.99 17 246914 558 42373846
Aspergillus infection 14.00 13.99 46 246885 15791 42358613

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Injection site erythema 46359.49 13.25 21901 1181974 72275 109313149
Injection site pain 44581.09 13.25 26335 1177540 151587 109233837
Injection site pruritus 25380.01 13.25 11983 1191892 39275 109346149
Injection site swelling 23964.75 13.25 12228 1191647 49562 109335862
Injection site reaction 15981.57 13.25 10692 1193183 78378 109307046
Injection site bruising 15839.20 13.25 8721 1195154 42542 109342882
Injection site warmth 13378.63 13.25 5545 1198330 11860 109373564
Arthralgia 9597.52 13.25 24058 1179817 755574 108629850
Wrong technique in product usage process 8404.19 13.25 7230 1196645 80118 109305306
Injection site haemorrhage 7630.48 13.25 4654 1199221 28374 109357050
Injection site rash 7513.60 13.25 4087 1199788 19332 109366092
Drug ineffective 6801.78 13.25 33514 1170361 1487026 107898398
Injection site urticaria 5724.71 13.25 3077 1200798 14138 109371286
Joint swelling 5611.83 13.25 13841 1190034 429004 108956420
Pain in extremity 5347.15 13.25 14424 1189451 472694 108912730
Acute kidney injury 5206.16 13.25 468 1203407 634962 108750462
Pain 4436.89 13.25 21317 1182558 933638 108451786
Injection site discolouration 4227.87 13.25 2039 1201836 7064 109378360
Nasopharyngitis 4225.92 13.25 11580 1192295 382781 109002643
Therapeutic product effect decreased 4006.75 13.25 8463 1195412 235853 109149571
Toxicity to various agents 3999.43 13.25 330 1203545 480225 108905199
Drug interaction 3964.53 13.25 418 1203457 499765 108885659
Injection site induration 3833.37 13.25 2052 1201823 9331 109376093
Product storage error 3749.69 13.25 2549 1201326 19179 109366245
Sinusitis 3531.08 13.25 9062 1194813 287626 109097798
Hypotension 3478.19 13.25 732 1203143 523117 108862307
Device issue 3380.87 13.25 2889 1200986 31646 109353778
Anaemia 3253.84 13.25 960 1202915 546126 108839298
Musculoskeletal stiffness 3081.43 13.25 8304 1195571 271518 109113906
Product dose omission issue 3071.00 13.25 9066 1194809 312716 109072708
Febrile neutropenia 3064.45 13.25 82 1203793 316685 109068739
Therapeutic product effect incomplete 2839.27 13.25 7006 1196869 216799 109168625
Accidental exposure to product 2747.69 13.25 3047 1200828 46961 109338463
Injection site mass 2733.16 13.25 2215 1201660 22398 109363026
Death 2674.34 13.25 2213 1201662 696656 108688768
Neutropenia 2630.72 13.25 455 1203420 374165 109011259
Completed suicide 2499.92 13.25 25 1203850 242356 109143068
Swelling 2424.28 13.25 8862 1195013 342179 109043245
Therapy interrupted 2335.59 13.25 2797 1201078 47025 109338399
Mobility decreased 2280.39 13.25 6707 1197168 230715 109154709
Hyponatraemia 1970.95 13.25 95 1203780 217558 109167866
Thrombocytopenia 1960.95 13.25 675 1203200 348210 109037214
Treatment failure 1919.78 13.25 7007 1196868 270227 109115197
Musculoskeletal pain 1895.09 13.25 5313 1198562 177710 109207714
Arthropathy 1891.59 13.25 7148 1196727 280374 109105050
Malignant neoplasm progression 1834.15 13.25 11 1203864 174556 109210868
Therapeutic response decreased 1806.42 13.25 3534 1200341 92965 109292459
Dyspnoea 1770.95 13.25 6160 1197715 1100712 108284712
Constipation 1727.61 13.25 868 1203007 356918 109028506
Joint stiffness 1709.06 13.25 2814 1201061 64429 109320995
Disease progression 1682.90 13.25 310 1203565 243724 109141700
Synovitis 1651.22 13.25 6628 1197247 267464 109117960
Arthritis 1610.85 13.25 4737 1199138 162849 109222575
Injection site discomfort 1604.02 13.25 977 1202898 5930 109379494
Drug intolerance 1573.44 13.25 8640 1195235 397872 108987552
Contraindicated product administered 1573.22 13.25 6100 1197775 242167 109143257
Drug abuse 1569.83 13.25 89 1203786 177322 109208102
Cardiac arrest 1547.84 13.25 168 1203707 196585 109188839
Peripheral swelling 1524.11 13.25 8528 1195347 395506 108989918
Dehydration 1487.43 13.25 590 1203285 278921 109106503
Injection site haematoma 1455.64 13.25 827 1203048 4319 109381105
Bradycardia 1450.59 13.25 55 1203820 155462 109229962
Injection site extravasation 1414.28 13.25 1046 1202829 9123 109376301
Pancytopenia 1413.99 13.25 281 1203594 209332 109176092
Underdose 1376.71 13.25 2478 1201397 61076 109324348
Respiratory failure 1376.68 13.25 326 1203549 215006 109170418
Hyperkalaemia 1336.14 13.25 29 1203846 135767 109249657
Intentional overdose 1320.94 13.25 24 1203851 132477 109252947
Diarrhoea 1270.95 13.25 7252 1196623 1132253 108253171
Seizure 1257.80 13.25 419 1203456 220766 109164658
Psoriasis 1238.67 13.25 3844 1200031 136149 109249275
Tachycardia 1206.39 13.25 478 1203397 226167 109159257
Abdominal pain 1200.35 13.25 2355 1201520 510634 108874790
Hypokalaemia 1192.63 13.25 263 1203612 182185 109203239
Rhabdomyolysis 1191.37 13.25 24 1203851 120377 109265047
Sepsis 1169.51 13.25 1103 1202772 326243 109059181
Musculoskeletal disorder 1164.58 13.25 1334 1202541 21330 109364094
Skin plaque 1160.85 13.25 1020 1202855 11625 109373799
Gastrointestinal haemorrhage 1145.81 13.25 208 1203667 165310 109220114
Hypoxia 1139.53 13.25 67 1203808 129448 109255976
Somnolence 1132.65 13.25 944 1202931 296505 109088919
Vomiting 1116.69 13.25 5611 1198264 905064 108480360
Electrocardiogram QT prolonged 1110.56 13.25 14 1203861 108946 109276478
Platelet count decreased 1108.94 13.25 561 1203314 229882 109155542
Haemoglobin decreased 1099.49 13.25 673 1203202 248054 109137370
Oxygen saturation decreased 1038.83 13.25 220 1203655 156762 109228662
Atrial fibrillation 1018.30 13.25 619 1203256 229023 109156401
Depressed level of consciousness 1016.22 13.25 49 1203826 112229 109273195
Neutrophil count decreased 985.72 13.25 90 1203785 120851 109264573
Renal failure 980.78 13.25 628 1203247 225946 109159478
Syncope 980.58 13.25 489 1203386 202047 109183377
Hypoglycaemia 980.49 13.25 74 1203801 116030 109269394
Knee arthroplasty 977.01 13.25 2175 1201700 62773 109322651
Cardio-respiratory arrest 958.21 13.25 81 1203794 115755 109269669
Injection site macule 955.83 13.25 318 1203557 224 109385200
Surgery 953.82 13.25 1656 1202219 39627 109345797
Multiple organ dysfunction syndrome 947.50 13.25 241 1203634 151469 109233955
Injection site recall reaction 932.99 13.25 288 1203587 99 109385325
Product use in unapproved indication 924.85 13.25 2200 1201675 445177 108940247
Lactic acidosis 924.31 13.25 17 1203858 92794 109292630
Metabolic acidosis 924.24 13.25 37 1203838 99707 109285717
Respiratory tract congestion 919.05 13.25 1389 1202486 29468 109355956
Pulmonary embolism 913.99 13.25 605 1203270 213869 109171555
Bronchitis 911.85 13.25 3756 1200119 153276 109232148
Suicide attempt 911.07 13.25 53 1203822 103341 109282083
Infection 909.50 13.25 6903 1196972 355297 109030127
Drug hypersensitivity 908.01 13.25 8220 1195655 445870 108939554
Cardiac failure 893.35 13.25 463 1203412 187163 109198261
Agitation 872.70 13.25 103 1203772 112948 109272476
Blood creatinine increased 863.83 13.25 456 1203419 182433 109202991
Oropharyngeal pain 838.34 13.25 3302 1200573 131974 109253450
Unevaluable event 834.82 13.25 1933 1201942 57294 109328130
Coma 833.51 13.25 140 1203735 117729 109267695
Overdose 832.15 13.25 790 1203085 233004 109152420
Red blood cell sedimentation rate abnormal 825.21 13.25 1169 1202706 23340 109362084
Hypersensitivity 815.48 13.25 7329 1196546 396669 108988755
International normalised ratio increased 788.07 13.25 37 1203838 86735 109298689
Myelosuppression 780.22 13.25 66 1203809 94274 109291150
Incorrect dose administered by device 766.48 13.25 618 1203257 6196 109379228
Drug reaction with eosinophilia and systemic symptoms 758.79 13.25 31 1203844 82064 109303360
Influenza 748.53 13.25 3733 1200142 165368 109220056
Cytokine release syndrome 745.97 13.25 3 1203872 70303 109315121
Renal impairment 744.70 13.25 576 1203299 187869 109197555
Alopecia 737.97 13.25 6621 1197254 358132 109027292
Off label use 731.28 13.25 11721 1192154 1488464 107896960
Hand deformity 725.97 13.25 4463 1199412 214043 109171381
Pleural effusion 720.44 13.25 529 1203346 177180 109208244
Blood pressure decreased 712.57 13.25 186 1203689 114905 109270519
Hallucination 700.77 13.25 128 1203747 101304 109284120
Hyperglycaemia 691.57 13.25 64 1203811 85026 109300398
Sedation 688.91 13.25 14 1203861 69669 109315755
White blood cell count decreased 687.96 13.25 892 1202983 228498 109156926
Injury associated with device 682.25 13.25 483 1203392 3906 109381518
Ascites 663.41 13.25 107 1203768 92701 109292723
Pneumonia aspiration 660.48 13.25 61 1203814 81172 109304252
Nodule 649.51 13.25 1227 1202648 31404 109354020
Cardiac failure congestive 644.52 13.25 425 1203450 150575 109234849
Neoplasm progression 638.50 13.25 13 1203862 64582 109320842
C-reactive protein abnormal 636.69 13.25 2950 1200925 126745 109258679
Mental status changes 635.73 13.25 51 1203824 76071 109309353
Weight decreased 632.60 13.25 2781 1201094 465276 108920148
Injection site vesicles 626.46 13.25 462 1203413 4009 109381415
Blood bilirubin increased 625.92 13.25 54 1203821 75918 109309506
Decreased appetite 625.86 13.25 2856 1201019 472990 108912434
Deep vein thrombosis 625.65 13.25 373 1203502 139514 109245910
Encephalopathy 625.22 13.25 74 1203801 80981 109304443
Blood pressure increased 623.71 13.25 1163 1202712 257210 109128214
Septic shock 617.96 13.25 485 1203390 157043 109228381
Fear of injection 612.40 13.25 612 1203263 8299 109377125
Pulmonary oedema 609.35 13.25 170 1203705 100489 109284935
Inflammation 608.20 13.25 3893 1199982 189345 109196079
Dysarthria 603.50 13.25 96 1203779 84025 109301399
Serotonin syndrome 596.67 13.25 9 1203866 59144 109326280
Melaena 585.72 13.25 42 1203833 68715 109316709
Orthostatic hypotension 577.48 13.25 36 1203839 66213 109319211
Tremor 574.45 13.25 818 1203057 201414 109184010
Mucosal inflammation 573.42 13.25 167 1203708 95974 109289450
Unresponsive to stimuli 570.35 13.25 30 1203845 63760 109321664
Acute myocardial infarction 569.60 13.25 110 1203765 83667 109301757
Headache 569.28 13.25 13081 1190794 869296 108516128
Herpes zoster 566.93 13.25 2512 1201363 105867 109279557
Injection site irritation 565.37 13.25 452 1203423 4472 109380952
Paranasal sinus hypersecretion 559.17 13.25 438 1203437 4196 109381228
Injection site inflammation 552.17 13.25 440 1203435 4331 109381093
Haematochezia 548.43 13.25 286 1203589 115238 109270186
Hypomagnesaemia 547.38 13.25 26 1203849 60344 109325080
Nausea 542.60 13.25 9834 1194041 1225856 108159568
Blood creatine phosphokinase increased 541.26 13.25 76 1203799 73001 109312423
Heart rate increased 539.16 13.25 463 1203412 143371 109242053
Cardiogenic shock 532.10 13.25 21 1203854 57317 109328107
Impaired healing 524.26 13.25 3804 1200071 192913 109192511
Dyspnoea exertional 523.81 13.25 238 1203637 103822 109281602
Respiratory distress 523.57 13.25 66 1203809 68808 109316616
Confusional state 519.91 13.25 2983 1200892 465697 108919727
Cholestasis 515.15 13.25 52 1203823 64466 109320958
Urinary retention 514.87 13.25 73 1203802 69610 109315814
Neuropathy peripheral 512.29 13.25 722 1203153 178555 109206869
Neck pain 511.76 13.25 2671 1201204 120459 109264965
Psoriatic arthropathy 505.03 13.25 3771 1200104 192990 109192434
Multiple sclerosis relapse 501.07 13.25 9 1203866 50231 109335193
Acute respiratory failure 500.83 13.25 104 1203771 75156 109310268
Angioedema 497.81 13.25 224 1203651 98276 109287148
Gait disturbance 496.36 13.25 4918 1198957 273290 109112134
Red blood cell sedimentation rate increased 495.22 13.25 1924 1201951 76378 109309046
Agranulocytosis 492.55 13.25 50 1203825 61710 109323714
Finger deformity 488.39 13.25 1100 1202775 31992 109353432
Drug dose omission by device 488.13 13.25 692 1203183 13824 109371600
Contusion 486.45 13.25 4265 1199610 229096 109156328
Leukopenia 484.87 13.25 542 1203333 148249 109237175
Respiratory arrest 484.22 13.25 40 1203835 58259 109327165
Asthenia 478.70 13.25 4992 1198883 684007 108701417
Toxic epidermal necrolysis 476.52 13.25 37 1203838 56690 109328734
Loss of consciousness 475.11 13.25 882 1202993 195424 109190000
Drug level increased 474.08 13.25 9 1203866 47710 109337714
Pyrexia 472.33 13.25 6911 1196964 891354 108494070
Foot deformity 468.77 13.25 1374 1202501 47106 109338318
Lymphocyte count decreased 460.02 13.25 45 1203830 57198 109328226
Pharyngitis streptococcal 459.91 13.25 642 1203233 12635 109372789
COVID-19 456.68 13.25 1269 1202606 243791 109141633
Hepatic cytolysis 456.63 13.25 38 1203837 55015 109330409
Suicidal ideation 455.70 13.25 226 1203649 93711 109291713
Dysphagia 455.58 13.25 602 1203273 152998 109232426
Bone marrow failure 453.21 13.25 50 1203825 57798 109327626
Heart rate decreased 450.96 13.25 168 1203707 82588 109302836
Coronary artery disease 449.24 13.25 113 1203762 71577 109313847
Hepatic failure 443.20 13.25 102 1203773 68637 109316787
Therapy non-responder 442.97 13.25 3083 1200792 154224 109231200
Neurotoxicity 441.46 13.25 3 1203872 42204 109343220
Blood pressure systolic increased 439.77 13.25 176 1203699 82815 109302609
Systemic lupus erythematosus 437.71 13.25 4463 1199412 249875 109135549
Eosinophilia 436.81 13.25 57 1203818 57879 109327545
Haematuria 436.63 13.25 178 1203697 82827 109302597
Psychotic disorder 431.34 13.25 32 1203843 50905 109334519
Hypervolaemia 430.72 13.25 27 1203848 49433 109335991
Altered state of consciousness 428.98 13.25 59 1203816 57567 109327857
Blood alkaline phosphatase increased 428.97 13.25 120 1203755 70815 109314609
Aggression 426.02 13.25 67 1203808 59143 109326281
Shock 425.76 13.25 44 1203831 53544 109331880
Feeling abnormal 425.66 13.25 3395 1200480 177316 109208108
Plasma cell myeloma 424.97 13.25 84 1203791 62852 109322572
Disorientation 424.68 13.25 121 1203754 70550 109314874
Ventricular tachycardia 424.67 13.25 31 1203844 49978 109335446
Fall 423.27 13.25 4362 1199513 599120 108786304
Rash maculo-papular 422.76 13.25 140 1203735 74082 109311342
Cerebral haemorrhage 421.69 13.25 95 1203780 64873 109320551
Cognitive disorder 417.82 13.25 215 1203660 87296 109298128
Cerebrovascular accident 415.66 13.25 841 1203034 180443 109204981
Osteoarthritis 415.56 13.25 3404 1200471 179219 109206205
Upper gastrointestinal haemorrhage 414.34 13.25 35 1203840 50061 109335363
Upper respiratory tract infection 413.82 13.25 2647 1201228 128681 109256743
Ear infection 413.58 13.25 1562 1202313 61170 109324254
Haematemesis 409.54 13.25 74 1203801 59034 109326390
Malaise 406.88 13.25 9876 1193999 661943 108723481
Gamma-glutamyltransferase increased 405.33 13.25 86 1203789 61223 109324201
Aspartate aminotransferase increased 401.87 13.25 702 1203173 159234 109226190
Pancreatitis acute 401.67 13.25 83 1203792 60191 109325233
Tubulointerstitial nephritis 400.75 13.25 57 1203818 54227 109331197
Generalised tonic-clonic seizure 397.69 13.25 60 1203815 54620 109330804
Drug ineffective for unapproved indication 396.52 13.25 322 1203553 102516 109282908
Rheumatoid factor positive 396.29 13.25 2623 1201252 129017 109256407
Colitis 396.27 13.25 319 1203556 102004 109283420
Hepatic enzyme increased 396.14 13.25 5281 1198594 315611 109069813
Alanine aminotransferase increased 395.91 13.25 883 1202992 182890 109202534
Grip strength decreased 395.12 13.25 1826 1202049 78348 109307076
Palpitations 393.56 13.25 706 1203169 158506 109226918
Chronic kidney disease 389.44 13.25 171 1203704 76120 109309304
Therapy cessation 388.38 13.25 1223 1202652 43634 109341790
Pneumonia 386.41 13.25 6969 1196906 869745 108515679
Condition aggravated 385.99 13.25 10600 1193275 724236 108661188
Hip arthroplasty 382.35 13.25 1407 1202468 54406 109331018
Jaundice 381.71 13.25 88 1203787 59148 109326276
Pemphigus 378.17 13.25 3784 1200091 210786 109174638
Rectal haemorrhage 377.99 13.25 448 1203427 119385 109266039
Accidental overdose 372.15 13.25 59 1203816 51775 109333649
Blood urea increased 371.82 13.25 73 1203802 54884 109330540
Sinus headache 370.53 13.25 390 1203485 5642 109379782
Diabetic ketoacidosis 366.13 13.25 23 1203852 42035 109343389
Sinus tachycardia 365.49 13.25 32 1203843 44461 109340963
Ventricular fibrillation 364.46 13.25 21 1203854 41292 109344132
Anti-cyclic citrullinated peptide antibody positive 364.20 13.25 3297 1200578 178687 109206737
Knee operation 361.88 13.25 414 1203461 6608 109378816
Leukocytosis 361.04 13.25 73 1203802 53755 109331669
Rhinorrhoea 357.86 13.25 2124 1201751 100542 109284882
Stevens-Johnson syndrome 356.36 13.25 45 1203830 46856 109338568
Neuroleptic malignant syndrome 353.37 13.25 3 1203872 34056 109351368
Haemorrhage 352.70 13.25 384 1203491 106308 109279116
Inappropriate antidiuretic hormone secretion 351.13 13.25 3 1203872 33848 109351576
Blood glucose increased 350.97 13.25 562 1203313 131934 109253490
Tachypnoea 350.71 13.25 19 1203856 39376 109346048
Circulatory collapse 350.25 13.25 32 1203843 42961 109342463
Injection site hypersensitivity 349.96 13.25 257 1203618 2214 109383210
Aphasia 349.02 13.25 104 1203771 58893 109326531
Blood lactate dehydrogenase increased 348.12 13.25 38 1203837 44296 109341128
Transplant dysfunction 347.35 13.25 441 1203434 7887 109377537
Arrhythmia 345.69 13.25 162 1203713 69413 109316011
Obstructive airways disorder 341.75 13.25 48 1203827 46101 109339323
Flushing 340.68 13.25 382 1203493 104354 109281070
Glossodynia 339.17 13.25 3804 1200071 218200 109167224
Back pain 338.87 13.25 5799 1198076 365197 109020227
Pulmonary hypertension 338.43 13.25 91 1203784 55129 109330295
Device difficult to use 337.54 13.25 677 1203198 18128 109367296
Hypocalcaemia 334.46 13.25 146 1203729 65220 109320204
Joint range of motion decreased 333.72 13.25 2372 1201503 119460 109265964
Intentional self-injury 333.36 13.25 18 1203857 37411 109348013
Foot operation 331.86 13.25 404 1203471 6909 109378515
Hepatocellular injury 330.79 13.25 73 1203802 50569 109334855
Drug withdrawal syndrome 330.70 13.25 21 1203854 38033 109347391
Adverse event 328.64 13.25 2170 1201705 106639 109278785
Acute respiratory distress syndrome 327.30 13.25 87 1203788 53111 109332313
Abdominal discomfort 326.29 13.25 6062 1197813 387796 108997628
Increased tendency to bruise 323.08 13.25 510 1203365 11248 109374176
Haemoptysis 322.19 13.25 188 1203687 71166 109314258
Rheumatoid nodule 321.37 13.25 694 1203181 19602 109365822
Hallucination, visual 321.25 13.25 30 1203845 39575 109345849
Fibromyalgia 321.16 13.25 3055 1200820 167854 109217570
Localised infection 321.16 13.25 1116 1202759 41932 109343492
Osteonecrosis of jaw 318.16 13.25 67 1203808 47950 109337474
Posterior reversible encephalopathy syndrome 315.57 13.25 12 1203863 33849 109351575
Bone erosion 315.13 13.25 1166 1202709 45205 109340219
Cerebral infarction 314.74 13.25 87 1203788 51751 109333673
Device expulsion 314.60 13.25 4 1203871 30887 109354537
Acute hepatic failure 314.32 13.25 21 1203854 36447 109348977
Injection site nodule 313.60 13.25 316 1203559 4330 109381094
Chest discomfort 307.16 13.25 923 1202952 172925 109212499
Pneumonitis 305.95 13.25 231 1203644 76300 109309124
Clostridium difficile colitis 305.05 13.25 54 1203821 43724 109341700
Electrolyte imbalance 303.16 13.25 27 1203848 37001 109348423
Tooth infection 301.99 13.25 715 1203160 21501 109363923
Labelled drug-drug interaction medication error 297.51 13.25 4 1203871 29298 109356126
Wound 297.41 13.25 3878 1199997 230559 109154865
Subdural haematoma 297.33 13.25 27 1203848 36427 109348997
Dizziness 296.92 13.25 5583 1198292 692610 108692814
Blood pressure fluctuation 295.10 13.25 229 1203646 74595 109310829
Loss of personal independence in daily activities 292.56 13.25 2703 1201172 147317 109238107
Sleep disorder due to general medical condition, insomnia type 292.35 13.25 2062 1201813 103581 109281843
Arthropod bite 291.74 13.25 438 1203437 9233 109376191
Status epilepticus 291.47 13.25 12 1203863 31559 109353865
Hepatic function abnormal 291.17 13.25 325 1203550 88970 109296454
Renal tubular necrosis 290.33 13.25 9 1203866 30466 109354958
No adverse event 289.93 13.25 227 1203648 73612 109311812
Pulmonary arterial hypertension 289.01 13.25 16 1203859 32552 109352872
Chest pain 288.14 13.25 2662 1201213 373713 109011711
Ejection fraction decreased 287.98 13.25 49 1203826 40831 109344593
Pericardial effusion 287.72 13.25 131 1203744 57086 109328338
Restlessness 285.73 13.25 127 1203748 56132 109329292
Joint destruction 284.72 13.25 463 1203412 10480 109374944
Hypothyroidism 283.85 13.25 226 1203649 72673 109312751
Troponin increased 282.82 13.25 9 1203866 29757 109355667
Haematoma 280.14 13.25 143 1203732 58333 109327091
Joint lock 279.55 13.25 264 1203611 3324 109382100
Chondrolysis 279.08 13.25 117 1203758 260 109385164
Haematocrit decreased 276.81 13.25 190 1203685 65927 109319497
Shoulder arthroplasty 276.46 13.25 263 1203612 3344 109382080
Bacteraemia 275.07 13.25 62 1203813 42328 109343096
Small intestinal obstruction 273.43 13.25 20 1203855 32193 109353231
Extrapyramidal disorder 273.31 13.25 9 1203866 28858 109356566
Coagulopathy 273.30 13.25 56 1203819 40855 109344569
Neutropenic sepsis 273.17 13.25 15 1203860 30731 109354693
Abnormal behaviour 272.36 13.25 48 1203827 38991 109346433
Poisoning 272.32 13.25 10 1203865 29095 109356329
Cytomegalovirus infection 271.67 13.25 126 1203749 54318 109331106
Limb discomfort 271.55 13.25 1020 1202855 39834 109345590
Tumour lysis syndrome 270.66 13.25 16 1203859 30785 109354639
Myoclonus 270.32 13.25 24 1203851 32974 109352450
Hyperbilirubinaemia 269.32 13.25 16 1203859 30655 109354769
Iritis 268.49 13.25 291 1203584 4361 109381063
Angina pectoris 264.85 13.25 176 1203699 62119 109323305
Anxiety 264.83 13.25 2439 1201436 342639 109042785
Ill-defined disorder 264.71 13.25 2742 1201133 154111 109231313
Lymphopenia 264.21 13.25 57 1203818 40113 109345311
Haemorrhage intracranial 264.17 13.25 12 1203863 28957 109356467
Hepatic encephalopathy 263.37 13.25 10 1203865 28246 109357178
Hemiparesis 262.25 13.25 76 1203799 43827 109341597
Blood calcium decreased 261.44 13.25 39 1203836 35806 109349618
Injection site injury 261.06 13.25 158 1203717 946 109384478
COVID-19 pneumonia 260.59 13.25 45 1203830 37098 109348326
Dyskinesia 256.80 13.25 119 1203756 51327 109334097
Chondropathy 255.26 13.25 228 1203647 2659 109382765
Sinus congestion 255.05 13.25 821 1203054 29638 109355786
Spinal operation 254.53 13.25 441 1203434 10531 109374893
Adverse reaction 254.47 13.25 805 1203070 28789 109356635
Sinus bradycardia 254.04 13.25 17 1203858 29466 109355958
Full blood count abnormal 254.04 13.25 147 1203728 55905 109329519
Shock haemorrhagic 252.75 13.25 10 1203865 27237 109358187
Anaphylactic shock 251.52 13.25 123 1203752 51423 109334001
Therapeutic product effect delayed 251.23 13.25 276 1203599 4203 109381221
Corrective lens user 251.11 13.25 98 1203777 165 109385259
Tuberculin test positive 250.37 13.25 251 1203624 3417 109382007
Acne 248.32 13.25 867 1203008 32653 109352771
Disability 247.98 13.25 809 1203066 29414 109356010
Device malfunction 246.71 13.25 724 1203151 24834 109360590
Ischaemic stroke 245.43 13.25 72 1203803 41191 109344233
Transaminases increased 244.96 13.25 198 1203677 63192 109322232
Rash 244.61 13.25 11099 1192776 809865 108575559
Dermatitis atopic 241.68 13.25 8 1203867 25533 109359891
Hypothermia 239.50 13.25 11 1203864 26291 109359133
Lethargy 239.35 13.25 406 1203469 93170 109292254
Myocarditis 237.93 13.25 25 1203850 30030 109355394
Chronic obstructive pulmonary disease 234.62 13.25 525 1203350 108633 109276791
Dystonia 234.30 13.25 11 1203864 25794 109359630
Joint effusion 234.07 13.25 625 1203250 20280 109365144
Withdrawal syndrome 233.87 13.25 32 1203843 31348 109354076
Antibiotic therapy 233.29 13.25 145 1203730 917 109384507
Ovarian cyst 232.89 13.25 487 1203388 13443 109371981
Balance disorder 232.67 13.25 583 1203292 115977 109269447
Cyanosis 232.23 13.25 26 1203849 29715 109355709
Ileus 232.21 13.25 30 1203845 30699 109354725
Joint noise 231.56 13.25 283 1203592 4860 109380564
Brain oedema 231.09 13.25 32 1203843 31066 109354358
Device dislocation 230.07 13.25 35 1203840 31669 109353755
Myocardial infarction 229.99 13.25 1191 1202684 190892 109194532
Breast cancer 229.92 13.25 930 1202945 37612 109347812
Delirium 229.89 13.25 729 1203146 134296 109251128
Hypoalbuminaemia 229.63 13.25 24 1203851 28950 109356474
Anuria 229.00 13.25 8 1203867 24333 109361091
Treatment noncompliance 228.96 13.25 274 1203601 72716 109312708
Device failure 228.32 13.25 334 1203541 6873 109378551
Presyncope 227.62 13.25 124 1203751 48763 109336661
Joint arthroplasty 226.79 13.25 234 1203641 3303 109382121
Cytopenia 226.14 13.25 30 1203845 30086 109355338
Blood pressure diastolic decreased 225.91 13.25 56 1203819 35829 109349595
Mycobacterium tuberculosis complex test positive 224.44 13.25 225 1203650 3063 109382361
Right ventricular failure 223.53 13.25 15 1203860 25939 109359485
Pericarditis 221.75 13.25 3484 1200391 215630 109169794
Intestinal obstruction 220.12 13.25 155 1203720 53072 109332352
Urinary incontinence 219.38 13.25 128 1203747 48459 109336965
Face oedema 219.09 13.25 48 1203827 33421 109352003
Pallor 218.67 13.25 176 1203699 56291 109329133
Product prescribing error 218.25 13.25 145 1203730 51186 109334238
Hypophagia 217.96 13.25 153 1203722 52473 109332951
Disseminated intravascular coagulation 216.37 13.25 89 1203786 41197 109344227
Discomfort 214.66 13.25 3407 1200468 211300 109174124
Shoulder operation 213.86 13.25 224 1203651 3221 109382203
Acidosis 213.40 13.25 7 1203868 22524 109362900
General physical health deterioration 213.18 13.25 3300 1200575 421995 108963429
Adverse drug reaction 212.40 13.25 1915 1201960 103644 109281780
Folliculitis 209.91 13.25 2767 1201108 164886 109220538
Eczema 208.57 13.25 289 1203586 72004 109313420
Oedema peripheral 207.90 13.25 2431 1201444 326229 109059195
Gait inability 207.80 13.25 2336 1201539 134040 109251384
Haemodynamic instability 207.03 13.25 10 1203865 22878 109362546
Helicobacter infection 207.02 13.25 2951 1200924 178926 109206498
Myalgia 206.59 13.25 1493 1202382 220888 109164536
Thrombotic microangiopathy 205.19 13.25 35 1203840 29114 109356310
Irritable bowel syndrome 204.66 13.25 2708 1201167 161507 109223917
Nightmare 203.31 13.25 84 1203791 38779 109346645
Cough 202.63 13.25 6515 1197360 455126 108930298
Transient ischaemic attack 200.89 13.25 240 1203635 63742 109321682
Parkinsonism 199.71 13.25 10 1203865 22177 109363247
Myelodysplastic syndrome 199.38 13.25 79 1203796 37405 109348019
Circumstance or information capable of leading to medication error 199.36 13.25 265 1203610 4968 109380456
Limb operation 198.56 13.25 232 1203643 3792 109381632
Disturbance in attention 198.46 13.25 229 1203646 61766 109323658
Left ventricular dysfunction 198.23 13.25 15 1203860 23478 109361946
Injection site papule 198.18 13.25 130 1203745 914 109384510
Muscle rigidity 198.16 13.25 17 1203858 24014 109361410
Blood potassium decreased 198.13 13.25 178 1203697 53936 109331488
Subarachnoid haemorrhage 197.70 13.25 41 1203834 29661 109355763
Ear pain 196.37 13.25 1118 1202757 52108 109333316
Mydriasis 196.26 13.25 11 1203864 22146 109363278
Blood pressure diastolic abnormal 195.56 13.25 25 1203850 25790 109359634
Muscle injury 195.47 13.25 2369 1201506 138438 109246986
Ataxia 195.43 13.25 44 1203831 30064 109355360
Haematotoxicity 194.67 13.25 8 1203867 21074 109364350
Acute generalised exanthematous pustulosis 194.25 13.25 10 1203865 21654 109363770
Toxic skin eruption 193.77 13.25 33 1203842 27482 109357942
Acute myeloid leukaemia 193.58 13.25 86 1203789 38024 109347400
Nephropathy toxic 193.41 13.25 33 1203842 27445 109357979
Activated partial thromboplastin time prolonged 192.43 13.25 13 1203862 22355 109363069
Cardiomegaly 192.27 13.25 41 1203834 29089 109356335
Blood sodium decreased 192.25 13.25 88 1203787 38231 109347193
Drug resistance 191.78 13.25 198 1203677 56176 109329248
Decreased immune responsiveness 190.88 13.25 361 1203514 9245 109376179
Malnutrition 189.30 13.25 34 1203841 27245 109358179
Joint warmth 189.20 13.25 167 1203708 1915 109383509
End stage renal disease 189.16 13.25 11 1203864 21462 109363962
Hypoaesthesia 188.96 13.25 4617 1199258 309606 109075818
Full blood count decreased 187.31 13.25 58 1203817 32041 109353383
Cholelithiasis 185.52 13.25 251 1203624 63171 109322253
Abdominal distension 184.00 13.25 1133 1202742 173970 109211454
Emotional distress 183.61 13.25 132 1203743 44715 109340709
Pancreatitis 183.44 13.25 472 1203403 93061 109292363
Joint injury 183.26 13.25 892 1202983 39102 109346322
Hallucination, auditory 182.97 13.25 33 1203842 26364 109359060
Anaphylactic reaction 182.95 13.25 634 1203241 113666 109271758
Aspiration 182.11 13.25 53 1203822 30480 109354944
Lower respiratory tract infection 181.49 13.25 3684 1200191 239422 109146002
Aplastic anaemia 180.66 13.25 25 1203850 24283 109361141
Klebsiella infection 180.16 13.25 9 1203866 20000 109365424
Bronchopulmonary aspergillosis 179.65 13.25 51 1203824 29812 109355612
Mania 179.16 13.25 12 1203863 20784 109364640
Nasal congestion 178.73 13.25 1745 1202130 96537 109288887
Transfusion 178.39 13.25 31 1203844 25441 109359983
Demyelination 178.34 13.25 347 1203528 9082 109376342
Duodenal ulcer perforation 177.68 13.25 2820 1201055 174880 109210544
Respiratory rate increased 176.82 13.25 30 1203845 25053 109360371
Tricuspid valve incompetence 176.37 13.25 25 1203850 23848 109361576
Atrial flutter 175.57 13.25 27 1203848 24235 109361189
Joint fluid drainage 175.17 13.25 80 1203795 236 109385188
Skin discolouration 174.93 13.25 1021 1202854 48025 109337399
Febrile bone marrow aplasia 174.69 13.25 3 1203872 17462 109367962
Bronchospasm 174.02 13.25 56 1203819 30183 109355241
Furuncle 173.79 13.25 327 1203548 8341 109377083
Gastritis 173.36 13.25 197 1203678 53502 109331922
Blood pressure systolic abnormal 172.38 13.25 31 1203844 24819 109360605
Hepatitis cholestatic 171.77 13.25 4 1203871 17562 109367862
Hypovolaemia 171.65 13.25 18 1203857 21656 109363768
Rubber sensitivity 171.58 13.25 169 1203706 2249 109383175
Hypernatraemia 170.85 13.25 5 1203870 17828 109367596
Proteinuria 170.20 13.25 113 1203762 39905 109345519
Cardiac failure acute 169.29 13.25 29 1203846 24049 109361375
Extra dose administered 169.26 13.25 395 1203480 11764 109373660
Oliguria 169.24 13.25 8 1203867 18649 109366775
Acute coronary syndrome 168.90 13.25 25 1203850 23087 109362337
Speech disorder 167.92 13.25 256 1203619 61313 109324111
Miosis 167.23 13.25 21 1203854 21962 109363462
Body temperature decreased 167.19 13.25 97 1203778 36838 109348586
Metastases to bone 167.06 13.25 66 1203809 31306 109354118
Paraesthesia oral 166.34 13.25 79 1203796 33592 109351832
Blister 166.21 13.25 3435 1200440 223941 109161483
Delusion 166.17 13.25 29 1203846 23726 109361698
Atrioventricular block complete 166.16 13.25 14 1203861 20068 109365356
Sinus disorder 165.36 13.25 751 1203124 31977 109353447
Diverticulitis 163.74 13.25 1071 1202804 52451 109332973
Clostridium difficile infection 163.17 13.25 196 1203679 51933 109333491
Cytomegalovirus viraemia 163.16 13.25 7 1203868 17757 109367667
Hyperphosphataemia 163.08 13.25 3 1203872 16378 109369046
Gastroenteritis 163.08 13.25 111 1203764 38689 109346735
Intentional product misuse 162.41 13.25 2184 1201691 130720 109254704
Drug level decreased 161.88 13.25 10 1203865 18538 109366886
Spinal fusion surgery 161.19 13.25 327 1203548 8829 109376595
Immune system disorder 160.72 13.25 413 1203462 13088 109372336
Enterocolitis 160.16 13.25 12 1203863 18937 109366487
Musculoskeletal discomfort 160.03 13.25 592 1203283 22946 109362478
Second primary malignancy 159.94 13.25 9 1203866 18059 109367365
Infusion site pain 159.54 13.25 7 1203868 17412 109368012
Glomerular filtration rate decreased 159.06 13.25 58 1203817 28898 109356526
Mitral valve incompetence 158.90 13.25 82 1203793 33247 109352177
Device related infection 158.31 13.25 119 1203756 39400 109346024
Myocardial ischaemia 157.90 13.25 47 1203828 26637 109358787
Supraventricular tachycardia 157.90 13.25 36 1203839 24386 109361038
Device use error 156.93 13.25 322 1203553 8767 109376657
Vascular device infection 156.85 13.25 5 1203870 16507 109368917
Diabetes mellitus inadequate control 156.33 13.25 64 1203811 29711 109355713
Hyperthermia 155.47 13.25 23 1203852 21249 109364175
Hyperthyroidism 155.09 13.25 62 1203813 29199 109356225
Renal injury 154.95 13.25 13 1203862 18700 109366724
Neutrophil count increased 154.03 13.25 93 1203782 34559 109350865
Impaired work ability 153.24 13.25 632 1203243 25787 109359637
Oesophagitis 151.94 13.25 61 1203814 28654 109356770
Fluid retention 150.99 13.25 523 1203352 93784 109291640
Arteriosclerosis coronary artery 150.91 13.25 43 1203832 25075 109360349
Paranoia 150.76 13.25 30 1203845 22344 109363080
Epistaxis 150.66 13.25 818 1203057 129554 109255870
Venoocclusive liver disease 150.52 13.25 3 1203872 15204 109370220
Sudden death 149.87 13.25 40 1203835 24355 109361069
Myopathy 149.46 13.25 43 1203832 24917 109360507
Pseudomonas infection 149.30 13.25 58 1203817 27795 109357629
Lipase increased 149.18 13.25 15 1203860 18657 109366767
Skin laceration 149.09 13.25 745 1203130 33008 109352416
Anhedonia 149.01 13.25 4 1203871 15424 109370000
Blood phosphorus increased 148.24 13.25 7 1203868 16333 109369091
Rash pruritic 148.09 13.25 1677 1202198 96392 109289032
Enterococcal infection 146.61 13.25 23 1203852 20343 109365081
Frequent bowel movements 146.44 13.25 352 1203523 71038 109314386
Urine output decreased 146.40 13.25 21 1203854 19855 109365569
Sneezing 146.29 13.25 713 1203162 31271 109354153
Oedema 145.88 13.25 1520 1202355 208456 109176968
Thrombosis 145.63 13.25 647 1203228 108015 109277409
Asthma 144.76 13.25 1887 1201988 248404 109137020
Hemiplegia 144.49 13.25 35 1203840 22747 109362677
Proctitis 142.28 13.25 11 1203864 16916 109368508
Swollen tongue 141.75 13.25 276 1203599 60086 109325338
Urticaria 140.82 13.25 4504 1199371 314353 109071071
Mass 140.47 13.25 502 1203373 19128 109366296
Therapy partial responder 140.42 13.25 118 1203757 36943 109348481
Flatulence 140.15 13.25 219 1203656 51930 109333494
Toxic encephalopathy 139.72 13.25 6 1203869 15208 109370216
Blood lactic acid increased 139.68 13.25 8 1203867 15813 109369611
Haemodialysis 139.59 13.25 15 1203860 17704 109367720
Salivary hypersecretion 139.17 13.25 14 1203861 17407 109368017
Peritonitis 138.77 13.25 92 1203783 32515 109352909
Rales 138.55 13.25 48 1203827 24691 109360733
Polyneuropathy 138.03 13.25 89 1203786 31923 109353501
Pulseless electrical activity 137.77 13.25 12 1203863 16745 109368679
Lower gastrointestinal haemorrhage 137.41 13.25 19 1203856 18467 109366957
Injection site paraesthesia 137.01 13.25 92 1203783 676 109384748
Red blood cell count decreased 136.05 13.25 324 1203551 65599 109319825
Hepatitis acute 135.53 13.25 21 1203854 18745 109366679
Blood loss anaemia 135.23 13.25 18 1203857 18007 109367417
Spinal pain 134.64 13.25 476 1203399 18039 109367385
Blood potassium increased 134.64 13.25 99 1203776 33150 109352274
Cardiomyopathy 134.23 13.25 101 1203774 33424 109352000
Arteriosclerosis 133.71 13.25 51 1203824 24716 109360708
Tardive dyskinesia 133.14 13.25 3 1203872 13576 109371848
Hypogammaglobulinaemia 133.03 13.25 28 1203847 20048 109365376
Atelectasis 132.92 13.25 122 1203753 36590 109348834
Female genital tract fistula 132.69 13.25 13 1203862 16506 109368918
Prothrombin time prolonged 132.50 13.25 16 1203859 17245 109368179
Poor venous access 131.55 13.25 51 1203824 24471 109360953
Dysgeusia 130.55 13.25 362 1203513 69623 109315801
Interstitial lung disease 130.54 13.25 933 1202942 138401 109247023
Ventricular extrasystoles 130.17 13.25 42 1203833 22599 109362825
Duodenal ulcer 129.75 13.25 27 1203848 19487 109365937
Anal incontinence 129.40 13.25 39 1203836 21925 109363499
Eye disorder 129.08 13.25 640 1203235 28266 109357158
Forced expiratory volume decreased 128.84 13.25 3 1203872 13173 109372251
Faeces discoloured 128.73 13.25 108 1203767 33840 109351584
Metastases to central nervous system 128.25 13.25 44 1203831 22773 109362651
Hypertension 128.08 13.25 4406 1199469 505678 108879746
Toothache 127.44 13.25 552 1203323 23023 109362401
Haemolytic anaemia 127.20 13.25 35 1203840 20885 109364539
Cyst 126.83 13.25 432 1203443 16064 109369360
Gastroenteritis viral 126.64 13.25 673 1203202 30553 109354871
Schizophrenia 126.35 13.25 40 1203835 21786 109363638
Hypertransaminasaemia 125.95 13.25 53 1203822 24202 109361222
Failure to thrive 125.84 13.25 5 1203870 13569 109371855
Bursitis 125.07 13.25 2049 1201826 127869 109257555
Lip swelling 124.86 13.25 225 1203650 50442 109334982
Injection site laceration 124.69 13.25 50 1203825 94 109385330
Kidney infection 124.58 13.25 581 1203294 25018 109360406
Colitis ulcerative 124.55 13.25 428 1203447 76935 109308489
Hyperlipidaemia 124.11 13.25 124 1203751 35724 109349700
Hypovolaemic shock 123.93 13.25 9 1203866 14574 109370850
Abdominal pain lower 123.40 13.25 134 1203741 37149 109348275
Polyuria 123.32 13.25 22 1203853 17716 109367708
Nail disorder 123.22 13.25 1064 1202811 56871 109328553
Asphyxia 123.06 13.25 8 1203867 14207 109371217
Eosinophil count increased 122.96 13.25 38 1203837 21020 109364404
Angina unstable 121.88 13.25 17 1203858 16415 109369009
Tooth disorder 121.74 13.25 639 1203236 28870 109356554
Drug dependence 121.59 13.25 224 1203651 49796 109335628
Erythema multiforme 121.53 13.25 39 1203836 21058 109364366
Jaundice cholestatic 121.37 13.25 10 1203865 14598 109370826
Complication associated with device 121.27 13.25 34 1203841 20039 109365385
Wrist surgery 121.11 13.25 90 1203785 791 109384633
Aspergillus infection 120.68 13.25 64 1203811 25552 109359872
Acute pulmonary oedema 120.54 13.25 20 1203855 16976 109368448
Immune thrombocytopenia 120.31 13.25 47 1203828 22447 109362977
Urosepsis 119.53 13.25 95 1203780 30580 109354844
Product dose omission in error 119.51 13.25 53 1203822 23459 109361965
Premature delivery 119.20 13.25 95 1203780 30537 109354887
Faecaloma 119.04 13.25 12 1203863 14896 109370528
Respiratory acidosis 119.04 13.25 8 1203867 13818 109371606
Appendicitis 118.87 13.25 82 1203793 28382 109357042
Meniscus injury 118.29 13.25 262 1203613 7531 109377893
Rheumatoid factor increased 117.94 13.25 141 1203734 2364 109383060
Incorrect disposal of product 117.66 13.25 105 1203770 1223 109384201
Hydronephrosis 117.63 13.25 39 1203836 20626 109364798
Substance abuse 117.58 13.25 4 1203871 12459 109372965
Metastases to liver 117.32 13.25 127 1203748 35259 109350165
Blood magnesium decreased 116.91 13.25 36 1203839 19960 109365464
Fatigue 116.89 13.25 15024 1188851 1200934 108184490
Fine motor skill dysfunction 116.36 13.25 229 1203646 6045 109379379
Infusion site erythema 115.88 13.25 3 1203872 11956 109373468
Exostosis 115.64 13.25 877 1202998 45079 109340345
Personality disorder 114.86 13.25 6 1203869 12831 109372593
Hypertriglyceridaemia 114.58 13.25 19 1203856 16135 109369289
Deformity 113.99 13.25 304 1203571 9856 109375568
Increased upper airway secretion 113.24 13.25 204 1203671 5028 109380396
Hyperhidrosis 113.14 13.25 1399 1202476 185899 109199525
Pulmonary alveolar haemorrhage 113.01 13.25 39 1203836 20111 109365313
Heart rate irregular 112.54 13.25 124 1203751 34150 109351274
Pemphigoid 112.52 13.25 37 1203838 19670 109365754
Psychomotor hyperactivity 112.43 13.25 40 1203835 20237 109365187
Pathogen resistance 112.37 13.25 27 1203848 17645 109367779
Apparent death 112.16 13.25 148 1203727 2754 109382670
Stress cardiomyopathy 111.21 13.25 19 1203856 15787 109369637
Peripheral sensory neuropathy 111.07 13.25 23 1203852 16657 109368767
Rebound effect 110.57 13.25 15 1203860 14791 109370633
Granulocytopenia 110.53 13.25 7 1203868 12708 109372716
Arthrodesis 110.31 13.25 142 1203733 2576 109382848
Hyperuricaemia 110.25 13.25 14 1203861 14517 109370907
Viral upper respiratory tract infection 110.07 13.25 301 1203574 9907 109375517
C-reactive protein increased 109.82 13.25 3129 1200746 214790 109170634
Osteonecrosis 109.77 13.25 123 1203752 33618 109351806
Chills 109.37 13.25 1439 1202436 189141 109196283
Limb deformity 109.23 13.25 167 1203708 3579 109381845
Vertigo 108.86 13.25 530 1203345 86340 109299084
Blood albumin decreased 108.55 13.25 85 1203790 27567 109357857
Ventricular hypokinesia 107.96 13.25 3 1203872 11211 109374213
Medication error 107.96 13.25 687 1203188 104679 109280745
Bronchiectasis 107.16 13.25 144 1203731 36349 109349075
Electrocardiogram abnormal 107.04 13.25 35 1203840 18674 109366750
Drug-induced liver injury 106.72 13.25 816 1203059 119251 109266173
Tinnitus 106.46 13.25 322 1203553 60218 109325206
Elbow deformity 106.15 13.25 105 1203770 1405 109384019
Haemophagocytic lymphohistiocytosis 106.04 13.25 112 1203763 31447 109353977
Uveitis 105.85 13.25 493 1203382 21217 109364207
Secretion discharge 105.62 13.25 469 1203406 19775 109365649
Cardiac murmur 105.47 13.25 69 1203806 24559 109360865
Rhinitis allergic 105.26 13.25 32 1203843 17890 109367534
Ankle deformity 104.87 13.25 76 1203799 640 109384784
Vision blurred 104.53 13.25 899 1202976 128123 109257301
Diastolic dysfunction 104.43 13.25 8 1203867 12396 109373028
Irritability 104.31 13.25 228 1203647 47581 109337843
Gastrointestinal disorder 104.26 13.25 3408 1200467 238544 109146880
Ankle operation 104.22 13.25 100 1203775 1286 109384138
White blood cell count increased 104.12 13.25 622 1203253 96220 109289204
Pneumothorax 103.85 13.25 139 1203736 35146 109350278
Apnoea 103.82 13.25 13 1203862 13626 109371798
Bundle branch block right 103.27 13.25 8 1203867 12283 109373141
Iron deficiency 103.21 13.25 36 1203839 18440 109366984
Atrioventricular block 103.06 13.25 28 1203847 16849 109368575
Myasthenia gravis 102.44 13.25 53 1203822 21458 109363966
Infusion site extravasation 102.36 13.25 6 1203869 11628 109373796
Oral candidiasis 102.23 13.25 208 1203667 44552 109340872
Cytomegalovirus infection reactivation 101.93 13.25 36 1203839 18297 109367127
Pneumonia bacterial 101.49 13.25 82 1203793 26179 109359245
Impaired quality of life 101.45 13.25 106 1203769 29911 109355513
Chromaturia 101.14 13.25 102 1203773 29258 109356166
Benign prostatic hyperplasia 101.05 13.25 36 1203839 18198 109367226
Clostridium test positive 101.03 13.25 4 1203871 10889 109374535
Hypertensive crisis 100.74 13.25 71 1203804 24301 109361123
Enthesopathy 100.56 13.25 332 1203543 12146 109373278
Intestinal ischaemia 100.39 13.25 26 1203849 16153 109369271
Upper respiratory tract congestion 100.22 13.25 143 1203732 2874 109382550
Adjustment disorder 100.00 13.25 4 1203871 10791 109374633
Drug level below therapeutic 99.79 13.25 7 1203868 11666 109373758
Bone disorder 99.50 13.25 476 1203399 20716 109364708
Neck surgery 99.41 13.25 119 1203756 1998 109383426
Intervertebral disc protrusion 99.03 13.25 577 1203298 27121 109358303
Iridocyclitis 98.62 13.25 196 1203679 5212 109380212
Cholecystitis 98.56 13.25 82 1203793 25800 109359624
Therapeutic response delayed 98.35 13.25 97 1203778 1293 109384131
Affect lability 97.94 13.25 40 1203835 18597 109366827
Amylase increased 97.60 13.25 11 1203864 12508 109372916
Haemolysis 97.30 13.25 25 1203850 15614 109369810
Pneumocystis jirovecii pneumonia 97.25 13.25 199 1203676 42536 109342888
Immune-mediated enterocolitis 97.05 13.25 3 1203872 10182 109375242
Back disorder 96.83 13.25 468 1203407 20454 109364970
Colitis ischaemic 96.74 13.25 36 1203839 17714 109367710
Respiratory symptom 96.68 13.25 22 1203853 14923 109370501
Macule 96.46 13.25 157 1203718 3556 109381868
Partial seizures 96.46 13.25 7 1203868 11342 109374082
Cardiac failure chronic 96.30 13.25 17 1203858 13794 109371630
Rheumatoid factor negative 96.25 13.25 93 1203782 1207 109384217
Graft versus host disease 96.21 13.25 42 1203833 18764 109366660
Night sweats 96.18 13.25 2019 1201856 131964 109253460
Ketoacidosis 96.01 13.25 3 1203872 10084 109375340
Ventricular arrhythmia 96.01 13.25 3 1203872 10084 109375340
Pulse absent 95.87 13.25 7 1203868 11285 109374139
Gallbladder operation 95.53 13.25 124 1203751 2269 109383155
Dialysis 95.43 13.25 47 1203828 19572 109365852
Diplopia 95.41 13.25 195 1203680 41699 109343725
Skin toxicity 95.36 13.25 9 1203866 11774 109373650
Cataract operation 95.24 13.25 203 1203672 5680 109379744
Left ventricular hypertrophy 95.24 13.25 15 1203860 13229 109372195
Hypercapnia 94.51 13.25 7 1203868 11152 109374272
Gastrooesophageal reflux disease 94.32 13.25 1384 1202491 178592 109206832
Erythema 94.10 13.25 3975 1199900 287472 109097952
Pulmonary haemorrhage 93.77 13.25 31 1203844 16425 109368999
Metabolic encephalopathy 93.49 13.25 7 1203868 11053 109374371
Ankylosing spondylitis 93.34 13.25 377 1203498 15235 109370189
Metastases to lung 92.96 13.25 69 1203806 22994 109362430
Skin ulcer 92.78 13.25 1081 1202794 62564 109322860
Pruritus 92.77 13.25 7442 1196433 574118 108811306
Tooth fracture 92.75 13.25 335 1203540 12832 109372592
Hospice care 92.29 13.25 13 1203862 12460 109372964
Hepatotoxicity 92.06 13.25 366 1203509 63034 109322390
Hip surgery 91.91 13.25 163 1203712 3967 109381457
Hypoacusis 91.61 13.25 677 1203198 34514 109350910
Lung opacity 91.45 13.25 10 1203865 11642 109373782
Panniculitis 91.35 13.25 374 1203501 15208 109370216
Hypopnoea 91.29 13.25 9 1203866 11371 109374053
Bronchitis chronic 91.24 13.25 180 1203695 4760 109380664
Chronic sinusitis 91.24 13.25 83 1203792 25001 109360423
Ageusia 91.20 13.25 50 1203825 19595 109365829
Blood calcium increased 91.17 13.25 41 1203834 17999 109367425
Haemorrhoids 90.99 13.25 155 1203720 35517 109349907
Tenosynovitis 90.90 13.25 385 1203490 15898 109369526
Animal bite 90.76 13.25 137 1203738 2902 109382522
Product prescribing issue 90.64 13.25 15 1203860 12757 109372667
Nasal polyps 90.42 13.25 17 1203858 13183 109372241
Escherichia bacteraemia 90.17 13.25 5 1203870 10159 109375265
Scratch 89.55 13.25 328 1203547 12651 109372773
Azotaemia 89.34 13.25 5 1203870 10080 109375344
Gangrene 89.30 13.25 33 1203842 16308 109369116
Nephropathy 88.79 13.25 19 1203856 13448 109371976
Tooth extraction 88.53 13.25 327 1203548 12664 109372760
Respiratory syncytial virus infection 88.50 13.25 24 1203851 14460 109370964
Blood triglycerides increased 88.43 13.25 78 1203797 23848 109361576
Dermatitis bullous 88.33 13.25 40 1203835 17489 109367935
Decubitus ulcer 88.23 13.25 44 1203831 18192 109367232
Device occlusion 87.60 13.25 28 1203847 15157 109370267
Cholangitis 87.58 13.25 34 1203841 16301 109369123
Synovial cyst 87.58 13.25 299 1203576 11131 109374293
Walking aid user 87.48 13.25 519 1203356 24556 109360868
Dysuria 87.27 13.25 348 1203527 59883 109325541
Infusion site swelling 87.18 13.25 5 1203870 9872 109375552
Blood parathyroid hormone decreased 87.14 13.25 327 1203548 12762 109372662
Enteritis 87.14 13.25 50 1203825 19106 109366318
Skin mass 87.14 13.25 270 1203605 9546 109375878
Tooth abscess 86.75 13.25 420 1203455 18369 109367055
Lung infiltration 86.63 13.25 84 1203791 24544 109360880
Guttate psoriasis 86.48 13.25 61 1203814 490 109384934
Intentional dose omission 86.42 13.25 440 1203435 19640 109365784
Methaemoglobinaemia 86.29 13.25 3 1203872 9165 109376259
Iron deficiency anaemia 86.27 13.25 131 1203744 31428 109353996
Electrocardiogram ST segment elevation 86.21 13.25 3 1203872 9157 109376267
Blood uric acid increased 86.02 13.25 65 1203810 21464 109363960
Granuloma skin 85.44 13.25 294 1203581 10989 109374435
Peritonitis bacterial 85.37 13.25 8 1203867 10525 109374899
Cystitis haemorrhagic 85.19 13.25 15 1203860 12194 109373230
Memory impairment 85.07 13.25 2775 1201100 194169 109191255
Ileus paralytic 85.07 13.25 13 1203862 11724 109373700
Alcohol poisoning 84.73 13.25 3 1203872 9017 109376407
Rheumatic fever 84.71 13.25 1837 1202038 120742 109264682
Hepatic necrosis 84.67 13.25 6 1203869 9916 109375508
Cerebral haematoma 84.64 13.25 5 1203870 9627 109375797
Pyelonephritis 84.40 13.25 90 1203785 25160 109360264
Cerebral ischaemia 84.18 13.25 15 1203860 12089 109373335
Hypotonia 84.04 13.25 33 1203842 15712 109369712
Nocturia 83.71 13.25 40 1203835 16950 109368474
Pneumonia fungal 83.71 13.25 28 1203847 14726 109370698
Purpura 83.69 13.25 85 1203790 24303 109361121
Systemic infection 83.61 13.25 6 1203869 9813 109375611
Bundle branch block left 83.32 13.25 19 1203856 12869 109372555
Brain herniation 83.07 13.25 3 1203872 8860 109376564
Surgical failure 83.05 13.25 74 1203801 860 109384564
Systemic inflammatory response syndrome 82.79 13.25 20 1203855 13023 109372401
Carpal tunnel decompression 82.64 13.25 73 1203802 838 109384586
Systemic candida 82.39 13.25 7 1203868 9967 109375457
Incontinence 82.22 13.25 39 1203836 16596 109368828
Apathy 81.92 13.25 37 1203838 16202 109369222
Behaviour disorder 81.85 13.25 6 1203869 9641 109375783
Drug tolerance decreased 81.75 13.25 547 1203328 26993 109358431
Clonus 81.52 13.25 3 1203872 8713 109376711
Lower limb fracture 81.51 13.25 1212 1202663 74136 109311288
Hallucinations, mixed 81.28 13.25 3 1203872 8690 109376734
Acute graft versus host disease 81.28 13.25 20 1203855 12861 109372563
Neurological symptom 81.21 13.25 34 1203841 15574 109369850
Hiccups 81.17 13.25 20 1203855 12849 109372575
Aplasia pure red cell 81.14 13.25 6 1203869 9572 109375852
Normochromic normocytic anaemia 80.99 13.25 21 1203854 13036 109372388
Endodontic procedure 80.66 13.25 132 1203743 3004 109382420
Bradyphrenia 80.56 13.25 15 1203860 11713 109373711
Laryngitis 80.53 13.25 760 1203115 41651 109343773
Oral mucosal exfoliation 80.19 13.25 94 1203781 1542 109383882
Atrial tachycardia 79.94 13.25 5 1203870 9173 109376251
Concomitant disease aggravated 79.91 13.25 39 1203836 16325 109369099
Coma scale abnormal 79.87 13.25 7 1203868 9719 109375705
Vaginal discharge 79.68 13.25 48 1203827 17860 109367564
Hypoxic-ischaemic encephalopathy 79.59 13.25 4 1203871 8843 109376581
Petechiae 79.19 13.25 82 1203793 23235 109362189
Aortic stenosis 79.12 13.25 22 1203853 13037 109372387
Mental disorder 78.97 13.25 192 1203683 38599 109346825
SLE arthritis 78.57 13.25 61 1203814 576 109384848
Rheumatoid lung 78.50 13.25 156 1203719 4148 109381276
Dissociation 78.39 13.25 8 1203867 9834 109375590
Rotator cuff syndrome 77.97 13.25 376 1203499 16418 109369006
Coordination abnormal 77.74 13.25 96 1203779 25132 109360292
Candida infection 77.68 13.25 265 1203610 47744 109337680
Gout 77.63 13.25 177 1203698 36389 109349035
Hyperreflexia 77.42 13.25 7 1203868 9478 109375946
Hyperlactacidaemia 76.99 13.25 3 1203872 8283 109377141
Gastritis erosive 76.96 13.25 18 1203857 11982 109373442
Cachexia 76.78 13.25 23 1203852 12982 109372442
Pulmonary fibrosis 76.62 13.25 1548 1202327 100494 109284930
Hepatomegaly 76.53 13.25 72 1203803 21342 109364082
Cardiac tamponade 76.52 13.25 15 1203860 11292 109374132
Ecchymosis 76.41 13.25 47 1203828 17291 109368133
Escherichia infection 76.19 13.25 88 1203787 23728 109361696
Oral surgery 76.02 13.25 87 1203788 1389 109384035
Atrioventricular block second degree 75.89 13.25 3 1203872 8178 109377246
Osteoporosis 75.70 13.25 1352 1202523 85800 109299624
Sleep apnoea syndrome 75.60 13.25 209 1203666 40238 109345186
Burning sensation 75.53 13.25 1115 1202760 68097 109317327
Neoplasm malignant 75.28 13.25 675 1203200 36468 109348956
Radiculopathy 75.20 13.25 60 1203815 19276 109366148
Rotator cuff repair 74.68 13.25 107 1203768 2159 109383265
Elbow operation 74.23 13.25 53 1203822 435 109384989
Carotid artery thrombosis 73.82 13.25 9 1203866 9629 109375795
Disease recurrence 73.77 13.25 375 1203500 60409 109325015
Bone swelling 73.69 13.25 95 1203780 1726 109383698
Hepatitis fulminant 73.56 13.25 5 1203870 8555 109376869
Brain natriuretic peptide increased 73.52 13.25 16 1203859 11193 109374231
Haemorrhagic stroke 73.44 13.25 29 1203846 13760 109371664
Rash erythematous 73.04 13.25 1275 1202600 80557 109304867
Pseudomonal sepsis 72.97 13.25 7 1203868 9039 109376385
Cardiovascular disorder 72.92 13.25 84 1203791 22676 109362748
Sickle cell anaemia with crisis 72.89 13.25 9 1203866 9536 109375888
Erectile dysfunction 72.89 13.25 57 1203818 18499 109366925
Lung consolidation 72.82 13.25 13 1203862 10463 109374961
Endophthalmitis 72.71 13.25 4 1203871 8183 109377241
Gastric disorder 72.71 13.25 616 1203259 32741 109352683
Lymphoma 72.63 13.25 421 1203454 19750 109365674
Carpal tunnel syndrome 72.57 13.25 458 1203417 22152 109363272
Cholecystitis chronic 72.45 13.25 9 1203866 9491 109375933
Protein urine present 72.13 13.25 18 1203857 11466 109373958
Cholecystitis acute 72.07 13.25 41 1203834 15741 109369683
Head injury 71.97 13.25 234 1203641 42783 109342641
Hypoventilation 71.61 13.25 4 1203871 8077 109377347
Dyspnoea at rest 71.36 13.25 5 1203870 8341 109377083
Tuberculosis 71.34 13.25 382 1203493 17392 109368032
Staphylococcal bacteraemia 71.13 13.25 47 1203828 16641 109368783
Blood pressure diastolic increased 71.10 13.25 60 1203815 18747 109366677
Arterial occlusive disease 71.01 13.25 39 1203836 15269 109370155
Fistula 70.94 13.25 39 1203836 15260 109370164
Dental operation 70.87 13.25 84 1203791 1395 109384029
Pustular psoriasis 70.83 13.25 315 1203560 13290 109372134
Brain injury 70.69 13.25 29 1203846 13447 109371977
Dementia 69.96 13.25 150 1203725 31523 109353901
Eating disorder 69.96 13.25 144 1203731 30714 109354710
Motor dysfunction 69.96 13.25 98 1203777 24308 109361116
Gastric ulcer 69.91 13.25 212 1203663 39615 109345809
Feeling hot 69.71 13.25 1386 1202489 89720 109295704
Intestinal perforation 69.62 13.25 75 1203800 20869 109364555
Rhinovirus infection 69.33 13.25 21 1203854 11768 109373656
Embolism 69.26 13.25 46 1203829 16243 109369181
Wrong product administered 69.19 13.25 17 1203858 10943 109374481
Hypertonia 69.16 13.25 6 1203869 8400 109377024
Wheelchair user 68.96 13.25 215 1203660 7627 109377797
Metabolic disorder 68.94 13.25 15 1203860 10495 109374929
Proctalgia 68.48 13.25 29 1203846 13193 109372231
Complication of device insertion 68.32 13.25 8 1203867 8830 109376594
Odynophagia 68.26 13.25 34 1203841 14067 109371357
Eye operation 68.24 13.25 112 1203763 2555 109382869
Injection site coldness 68.05 13.25 32 1203843 103 109385321
Injection site hypoaesthesia 67.99 13.25 58 1203817 633 109384791
Latent tuberculosis 67.61 13.25 140 1203735 3837 109381587
Middle insomnia 67.50 13.25 74 1203801 20428 109364996
Coeliac disease 67.22 13.25 743 1203132 42444 109342980
Intracranial pressure increased 67.18 13.25 16 1203859 10519 109374905
Multiple-drug resistance 67.01 13.25 30 1203845 13205 109372219
Sciatica 66.84 13.25 1394 1202481 91005 109294419
Product administration interrupted 66.61 13.25 20 1203855 11272 109374152
Thirst 66.47 13.25 83 1203792 21624 109363800
Exposure during pregnancy 66.28 13.25 1354 1202521 166070 109219354
Blood pressure systolic decreased 65.68 13.25 32 1203843 13409 109372015
Vulvovaginal mycotic infection 65.57 13.25 166 1203709 5211 109380213
Gynaecomastia 65.48 13.25 12 1203863 9478 109375946
Coronary artery stenosis 65.36 13.25 34 1203841 13724 109371700
Device dispensing error 65.30 13.25 37 1203838 192 109385232
Blood thyroid stimulating hormone increased 65.30 13.25 26 1203849 12275 109373149
Chronic graft versus host disease 65.16 13.25 12 1203863 9445 109375979
Joint surgery 65.07 13.25 45 1203830 349 109385075
Tachyarrhythmia 65.06 13.25 7 1203868 8254 109377170
Bone cyst 65.00 13.25 130 1203745 3473 109381951
Cardiac disorder 64.72 13.25 525 1203350 75755 109309669
Influenza like illness 64.65 13.25 1336 1202539 87076 109298348
Drug effective for unapproved indication 64.41 13.25 37 1203838 14130 109371294
Blood phosphorus decreased 64.37 13.25 5 1203870 7660 109377764
Blood chloride decreased 64.04 13.25 11 1203864 9104 109376320
Wheezing 63.86 13.25 2205 1201670 253025 109132399
Splenomegaly 63.83 13.25 105 1203770 24393 109361031
Joint laxity 63.77 13.25 105 1203770 2402 109383022
Drug therapy 63.42 13.25 4 1203871 7287 109378137
Neutrophilia 63.33 13.25 17 1203858 10312 109375112
Hiatus hernia 63.29 13.25 128 1203747 27478 109357946
Eye infection 63.10 13.25 319 1203556 14199 109371225
Thyroid neoplasm 63.06 13.25 122 1203753 3179 109382245
Post procedural haemorrhage 63.05 13.25 46 1203829 15466 109369958
Eosinophilic pneumonia 62.76 13.25 4 1203871 7223 109378201
Ischaemic cardiomyopathy 62.55 13.25 7 1203868 8004 109377420
Catheter site infection 62.44 13.25 7 1203868 7993 109377431
International normalised ratio decreased 62.33 13.25 8 1203867 8228 109377196
Steroid dependence 62.26 13.25 9 1203866 8460 109376964
Nystagmus 62.23 13.25 24 1203851 11553 109373871
Renal tubular disorder 61.96 13.25 5 1203870 7424 109378000
Stress 61.75 13.25 1543 1202332 103805 109281619
Arteriospasm coronary 61.74 13.25 12 1203863 9088 109376336
Bunion operation 61.63 13.25 63 1203812 879 109384545
Ischaemia 61.57 13.25 12 1203863 9071 109376353
Protein total decreased 61.21 13.25 21 1203854 10869 109374555
Mental impairment 60.90 13.25 95 1203780 22544 109362880
Red cell distribution width increased 60.80 13.25 61 1203814 17541 109367883
Tenderness 60.71 13.25 537 1203338 28900 109356524
Induration 60.69 13.25 100 1203775 2289 109383135
Hyperpyrexia 60.67 13.25 8 1203867 8061 109377363
Joint dislocation 60.65 13.25 604 1203271 33586 109351838
Rash papular 60.56 13.25 511 1203364 27128 109358296
Depressed mood 60.50 13.25 400 1203475 60409 109325015
Wound infection 60.49 13.25 1426 1202449 95039 109290385
Post procedural infection 60.42 13.25 304 1203571 13505 109371919
Tendon operation 60.40 13.25 39 1203836 266 109385158
Duodenal ulcer haemorrhage 60.36 13.25 8 1203867 8029 109377395
Parainfluenzae virus infection 60.15 13.25 4 1203871 6970 109378454
Product complaint 60.03 13.25 39 1203836 13933 109371491
Human antichimeric antibody positive 59.98 13.25 84 1203791 1658 109383766
Stridor 59.33 13.25 4 1203871 6891 109378533
Malignant melanoma 59.17 13.25 350 1203525 16541 109368883
Procedural pain 59.13 13.25 194 1203681 35371 109350053
Onychomycosis 59.10 13.25 661 1203214 37870 109347554
Muscle haemorrhage 59.07 13.25 4 1203871 6865 109378559
Scab 59.05 13.25 293 1203582 12943 109372481
Glycosylated haemoglobin increased 58.99 13.25 104 1203771 23515 109361909
Orthopnoea 58.99 13.25 23 1203852 10998 109374426
Pulmonary vasculitis 58.91 13.25 3 1203872 6557 109378867
Mucormycosis 58.87 13.25 21 1203854 10607 109374817
Nasal oedema 58.76 13.25 4 1203871 6835 109378589
Gastric haemorrhage 58.68 13.25 52 1203823 15863 109369561
Exercise tolerance decreased 58.56 13.25 29 1203846 12038 109373386
Blood culture positive 58.49 13.25 13 1203862 8963 109376461
Lip oedema 58.45 13.25 7 1203868 7593 109377831
Catarrh 58.32 13.25 6 1203869 7329 109378095
Renal cyst 58.29 13.25 67 1203808 18105 109367319
Arthropod sting 58.25 13.25 75 1203800 1361 109384063
Musculoskeletal deformity 58.17 13.25 78 1203797 1475 109383949
Large intestine perforation 58.16 13.25 57 1203818 16572 109368852
Intentional product use issue 58.10 13.25 2159 1201716 245747 109139677
Breath sounds abnormal 58.06 13.25 118 1203757 25286 109360138
Nerve injury 58.03 13.25 251 1203624 10462 109374962
Exposure to toxic agent 57.86 13.25 34 1203841 12824 109372600
Toe operation 57.77 13.25 63 1203812 951 109384473
Catheter site pain 57.72 13.25 3 1203872 6443 109378981
Polyarthritis 57.71 13.25 379 1203496 18584 109366840
Hysterectomy 57.63 13.25 207 1203668 7907 109377517
Swollen joint count increased 57.55 13.25 1253 1202622 82408 109303016
Wrist deformity 57.46 13.25 115 1203760 3074 109382350
Sleep disorder due to a general medical condition 57.45 13.25 332 1203543 51780 109333644
Injection site oedema 57.40 13.25 85 1203790 1769 109383655
Obsessive-compulsive disorder 57.38 13.25 6 1203869 7235 109378189
Blood immunoglobulin E increased 57.27 13.25 7 1203868 7475 109377949
Road traffic accident 57.13 13.25 1553 1202322 105845 109279579
Swelling of eyelid 56.84 13.25 4 1203871 6649 109378775
Aortic arteriosclerosis 56.64 13.25 24 1203851 10914 109374510
Nervousness 56.45 13.25 632 1203243 36219 109349205
Post transplant lymphoproliferative disorder 56.38 13.25 52 1203823 15561 109369863
Diffuse large B-cell lymphoma recurrent 56.19 13.25 3 1203872 6296 109379128
Supraventricular extrasystoles 56.15 13.25 10 1203865 8063 109377361
Peripheral ischaemia 56.09 13.25 25 1203850 11033 109374391
Venous thrombosis 56.07 13.25 12 1203863 8493 109376931
Lip dry 56.05 13.25 1457 1202418 98626 109286798
Diabetes insipidus 55.99 13.25 4 1203871 6566 109378858
Necrosis 55.97 13.25 27 1203848 11379 109374045
Pulmonary function test decreased 55.90 13.25 13 1203862 8687 109376737
Sensory loss 55.87 13.25 92 1203783 21365 109364059
Retinal haemorrhage 55.74 13.25 17 1203858 9484 109375940
Petit mal epilepsy 55.53 13.25 8 1203867 7539 109377885
Femoral neck fracture 55.47 13.25 34 1203841 12533 109372891
Glaucoma 55.13 13.25 427 1203448 22090 109363334
Euphoric mood 55.13 13.25 14 1203861 8813 109376611
Foetal exposure during pregnancy 55.11 13.25 8 1203867 7497 109377927
Genital haemorrhage 54.99 13.25 7 1203868 7245 109378179
Respiration abnormal 54.98 13.25 19 1203856 9790 109375634
Rash morbilliform 54.98 13.25 10 1203865 7941 109377483
Hydrocephalus 54.96 13.25 22 1203853 10353 109375071
Myositis 54.35 13.25 166 1203709 30950 109354474
Faeces soft 54.31 13.25 27 1203848 11183 109374241
Pneumatosis intestinalis 54.29 13.25 13 1203862 8516 109376908
Bedridden 54.20 13.25 289 1203586 13136 109372288
Orthosis user 54.00 13.25 24 1203851 65 109385359
Skin disorder 53.97 13.25 709 1203166 42204 109343220
Tendonitis 53.88 13.25 476 1203399 25607 109359817
Infection susceptibility increased 53.87 13.25 136 1203739 4262 109381162
Serum ferritin increased 53.78 13.25 31 1203844 11816 109373608
Cerebral atrophy 53.76 13.25 16 1203859 9069 109376355
Cytomegalovirus chorioretinitis 53.76 13.25 7 1203868 7121 109378303
Asthma-chronic obstructive pulmonary disease overlap syndrome 53.67 13.25 4 1203871 6340 109379084
Ammonia increased 53.66 13.25 12 1203863 8238 109377186
Encephalitis 53.65 13.25 76 1203799 18763 109366661
Total lung capacity decreased 53.62 13.25 7 1203868 7107 109378317
Dyslipidaemia 53.26 13.25 57 1203818 15908 109369516
Facet joint syndrome 53.18 13.25 1406 1202469 95422 109290002
Atlantoaxial instability 53.13 13.25 36 1203839 269 109385155
Dust allergy 53.09 13.25 3 1203872 5998 109379426
Ventricular dysfunction 52.91 13.25 9 1203866 7502 109377922
Sacroiliitis 52.90 13.25 146 1203729 4832 109380592
Body height below normal 52.63 13.25 87 1203788 1997 109383427
Eye movement disorder 52.57 13.25 20 1203855 9708 109375716
Occult blood positive 52.27 13.25 9 1203866 7436 109377988
Nail pitting 52.23 13.25 43 1203832 445 109384979
Nerve compression 52.17 13.25 250 1203625 10887 109374537
Aplasia 52.13 13.25 11 1203864 7862 109377562
Fibrin D dimer increased 51.95 13.25 21 1203854 9824 109375600
Blood pressure inadequately controlled 51.92 13.25 10 1203865 7623 109377801
Non-cardiac chest pain 51.81 13.25 23 1203852 10175 109375249
Endotracheal intubation 51.62 13.25 4 1203871 6140 109379284
Stenotrophomonas infection 51.60 13.25 3 1203872 5855 109379569
Dental implantation 51.58 13.25 51 1203824 682 109384742
Intervertebral disc operation 51.56 13.25 61 1203814 1011 109384413
Drooling 51.53 13.25 8 1203867 7131 109378293
Abortion induced 51.49 13.25 12 1203863 8007 109377417
Systemic lupus erythematosus rash 51.45 13.25 85 1203790 1950 109383474
Escherichia urinary tract infection 51.40 13.25 60 1203815 16102 109369322
Throat irritation 51.29 13.25 844 1203031 52708 109332716
Blood creatine increased 51.09 13.25 31 1203844 11490 109373934
Epilepsy 50.97 13.25 775 1203100 99434 109285990
Gastric ulcer haemorrhage 50.92 13.25 23 1203852 10071 109375353
Embolic stroke 50.65 13.25 16 1203859 8727 109376697
Ventricular hypertrophy 50.61 13.25 8 1203867 7037 109378387
Cytomegalovirus test positive 50.52 13.25 8 1203867 7028 109378396
Haemothorax 50.47 13.25 8 1203867 7023 109378401
Renal disorder 50.47 13.25 323 1203552 49156 109336268
Persecutory delusion 50.40 13.25 5 1203870 6286 109379138
Gastrointestinal perforation 50.23 13.25 10 1203865 7446 109377978
Abdominal wall haematoma 50.02 13.25 3 1203872 5702 109379722
Bone graft 50.01 13.25 52 1203823 741 109384683
Electrocardiogram T wave inversion 49.76 13.25 3 1203872 5677 109379747
Pneumonia cytomegaloviral 49.72 13.25 8 1203867 6946 109378478
Prostatic specific antigen increased 49.69 13.25 38 1203837 12473 109372951
Portal hypertension 49.69 13.25 16 1203859 8621 109376803
Aortic valve incompetence 49.47 13.25 29 1203846 10952 109374472
Bacterial infection 49.31 13.25 296 1203579 45740 109339684
Electroencephalogram abnormal 49.21 13.25 5 1203870 6168 109379256
Central nervous system lesion 49.18 13.25 58 1203817 15495 109369929
Sensitivity to weather change 49.09 13.25 228 1203647 9800 109375624
Neurological decompensation 49.03 13.25 8 1203867 6875 109378549
Scleritis 48.97 13.25 150 1203725 5270 109380154
Scar 48.74 13.25 333 1203542 16548 109368876
Sleep terror 48.65 13.25 7 1203868 6603 109378821
Diverticulum intestinal 48.62 13.25 34 1203841 11685 109373739
Spinal instability 48.61 13.25 41 1203834 440 109384984
Exposure to communicable disease 48.58 13.25 45 1203830 552 109384872
Spinal disorder 48.40 13.25 254 1203621 11474 109373950
Micturition urgency 48.32 13.25 85 1203790 19235 109366189
Sinus node dysfunction 48.22 13.25 19 1203856 9028 109376396
Anosmia 48.13 13.25 39 1203836 12433 109372991
Periorbital swelling 47.95 13.25 3 1203872 5502 109379922
Major depression 47.92 13.25 28 1203847 10593 109374831
Dental care 47.54 13.25 59 1203816 1030 109384394
Faecal calprotectin increased 47.44 13.25 8 1203867 6711 109378713
Self-medication 47.29 13.25 6 1203869 6226 109379198
Stress at work 47.28 13.25 65 1203810 1260 109384164
Periorbital oedema 47.23 13.25 26 1203849 10166 109375258
Lupus-like syndrome 47.22 13.25 664 1203211 40128 109345296
Vasculitis 47.21 13.25 215 1203660 35658 109349766
Injection site pustule 47.19 13.25 23 1203852 82 109385342
Congestive cardiomyopathy 47.17 13.25 51 1203824 14168 109371256
Oesophageal ulcer 47.17 13.25 14 1203861 7950 109377474
Atypical femur fracture 47.16 13.25 6 1203869 6213 109379211
Injection site scar 46.96 13.25 60 1203815 1080 109384344
Laryngeal oedema 46.94 13.25 24 1203851 9783 109375641
Oxygen consumption increased 46.93 13.25 4 1203871 5681 109379743
Mean cell volume increased 46.93 13.25 16 1203859 8314 109377110
Skin haemorrhage 46.69 13.25 444 1203431 24383 109361041
Nephrotic syndrome 46.56 13.25 49 1203826 13782 109371642
Skin injury 46.56 13.25 121 1203754 3861 109381563
Nocardiosis 46.51 13.25 12 1203863 7474 109377950
Stomatitis 46.42 13.25 3479 1200396 266763 109118661
Liver function test increased 46.41 13.25 1278 1202597 87270 109298154
Performance status decreased 46.40 13.25 11 1203864 7255 109378169
Duodenitis 46.31 13.25 21 1203854 9175 109376249
Dermatitis acneiform 46.18 13.25 42 1203833 12653 109372771
Knee deformity 46.03 13.25 70 1203805 1493 109383931
Left ventricular failure 46.00 13.25 34 1203841 11355 109374069
Spinal stenosis 45.90 13.25 360 1203515 18696 109366728
Physical disability 45.84 13.25 141 1203734 4965 109380459
Fluid intake reduced 45.76 13.25 10 1203865 6976 109378448
BK virus infection 45.75 13.25 45 1203830 13061 109372363
Throat tightness 45.71 13.25 198 1203677 33291 109352133
Dermatitis exfoliative 45.66 13.25 34 1203841 11313 109374111
Plasmacytoma 45.44 13.25 3 1203872 5259 109380165
Blood bicarbonate decreased 45.43 13.25 5 1203870 5792 109379632
Product label confusion 45.39 13.25 411 1203464 22266 109363158
Hypoglycaemic coma 45.39 13.25 4 1203871 5529 109379895
Tumour haemorrhage 45.26 13.25 3 1203872 5242 109380182
Obstruction 44.98 13.25 5 1203870 5747 109379677
Bacterial sepsis 44.93 13.25 29 1203846 10397 109375027
Foot fracture 44.69 13.25 450 1203425 25096 109360328
Injection site anaesthesia 44.63 13.25 16 1203859 18 109385406
Device power source issue 44.61 13.25 64 1203811 1293 109384131
Epstein-Barr virus infection 44.58 13.25 85 1203790 18653 109366771
Gastrointestinal necrosis 44.53 13.25 9 1203866 6631 109378793
Ligament rupture 44.53 13.25 120 1203755 3915 109381509
Staphylococcal sepsis 44.37 13.25 76 1203799 17378 109368046
Sarcoidosis 44.29 13.25 261 1203614 12318 109373106
Injection site exfoliation 44.25 13.25 37 1203838 392 109385032
Blood immunoglobulin G decreased 44.04 13.25 4 1203871 5396 109380028
Parosmia 44.03 13.25 47 1203828 13133 109372291
International normalised ratio abnormal 43.94 13.25 8 1203867 6349 109379075
Burn infection 43.79 13.25 17 1203858 28 109385396
SARS-CoV-2 test positive 43.73 13.25 73 1203802 16862 109368562
Mass excision 43.72 13.25 35 1203840 347 109385077
Colonoscopy 43.58 13.25 83 1203792 2137 109383287
Application site erythema 43.56 13.25 5 1203870 5605 109379819
Back injury 43.55 13.25 742 1203133 46657 109338767
Fungaemia 43.52 13.25 7 1203868 6079 109379345
Onychomadesis 43.49 13.25 719 1203156 44944 109340480
Pharyngitis 43.37 13.25 441 1203434 24657 109360767
Thrombosis in device 43.30 13.25 4 1203871 5323 109380101
Depression 43.28 13.25 2923 1200952 314412 109071012
Haemarthrosis 43.20 13.25 13 1203862 7316 109378108
Thrombotic thrombocytopenic purpura 43.04 13.25 12 1203863 7099 109378325
Autonomic nervous system imbalance 42.82 13.25 6 1203869 5774 109379650
Hernia repair 42.79 13.25 89 1203786 2447 109382977
Cardiac dysfunction 42.66 13.25 8 1203867 6215 109379209
Intraventricular haemorrhage 42.53 13.25 5 1203870 5502 109379922
Blood iron abnormal 42.38 13.25 66 1203809 1438 109383986
Pharyngeal swelling 42.36 13.25 41 1203834 11991 109373433
High density lipoprotein decreased 42.36 13.25 6 1203869 5727 109379697
Drug screen positive 42.35 13.25 9 1203866 6401 109379023
Neoplasm recurrence 42.33 13.25 4 1203871 5228 109380196
Swelling face 42.30 13.25 728 1203147 91593 109293831
Logorrhoea 42.29 13.25 3 1203872 4954 109380470
Red blood cell sedimentation rate 42.26 13.25 139 1203736 5075 109380349
Incoherent 42.23 13.25 19 1203856 8339 109377085
Pericardial haemorrhage 42.18 13.25 4 1203871 5213 109380211
Pseudomembranous colitis 42.17 13.25 9 1203866 6382 109379042
Electrocardiogram ST segment depression 42.07 13.25 5 1203870 5456 109379968
Immune reconstitution inflammatory syndrome 41.85 13.25 70 1203805 16156 109369268
Neutrophil percentage increased 41.84 13.25 3 1203872 4910 109380514
Eyelid ptosis 41.82 13.25 50 1203825 13277 109372147
Hangnail 41.79 13.25 15 1203860 17 109385407
Breast cancer stage III 41.78 13.25 1143 1202732 77974 109307450
Personality change 41.71 13.25 35 1203840 10967 109374457
Oral herpes 41.64 13.25 587 1203288 35493 109349931
Generalised oedema 41.62 13.25 182 1203693 30522 109354902
Ear congestion 41.46 13.25 110 1203765 3555 109381869
Mineral metabolism disorder 41.40 13.25 35 1203840 377 109385047
Palmoplantar keratoderma 41.33 13.25 5 1203870 5382 109380042
Injection site dryness 41.18 13.25 43 1203832 616 109384808
Hospitalisation 41.17 13.25 1208 1202667 141285 109244139
Meniscus operation 41.12 13.25 24 1203851 133 109385291
Loose body in joint 40.97 13.25 63 1203812 1357 109384067
Blindness 40.96 13.25 230 1203645 36129 109349295
Cardiac operation 40.94 13.25 151 1203724 5844 109379580
Enterobacter infection 40.85 13.25 7 1203868 5804 109379620
Type IV hypersensitivity reaction 40.83 13.25 8 1203867 6025 109379399
Type 2 diabetes mellitus 40.77 13.25 2339 1201536 174893 109210531
Cyst removal 40.77 13.25 38 1203837 470 109384954
Eosinophil count decreased 40.69 13.25 8 1203867 6010 109379414
Cell death 40.66 13.25 7 1203868 5784 109379640
Ovarian neoplasm 40.64 13.25 42 1203833 594 109384830
Bilirubin conjugated increased 40.59 13.25 9 1203866 6215 109379209
Spider vein 40.52 13.25 30 1203845 262 109385162
Paralysis 40.51 13.25 67 1203808 15533 109369891
Conjunctival haemorrhage 40.51 13.25 11 1203864 6622 109378802
Pneumonia klebsiella 40.50 13.25 11 1203864 6621 109378803
Neck mass 40.40 13.25 130 1203745 4691 109380733
Dislocation of vertebra 40.38 13.25 685 1203190 43036 109342388
Syringe issue 40.36 13.25 27 1203848 9498 109375926
Somnambulism 40.31 13.25 10 1203865 6395 109379029
Progressive multifocal leukoencephalopathy 40.21 13.25 138 1203737 24818 109360606
Platelet count increased 40.18 13.25 149 1203726 26185 109359239
Product administration error 40.02 13.25 239 1203636 36978 109348446
Areflexia 39.91 13.25 12 1203863 6757 109378667
Haemolytic uraemic syndrome 39.84 13.25 4 1203871 4981 109380443
Colorectal cancer 39.76 13.25 25 1203850 9089 109376335
Troponin I increased 39.60 13.25 6 1203869 5446 109379978
General symptom 39.59 13.25 196 1203679 8650 109376774
Product substitution issue 39.59 13.25 124 1203751 22937 109362487
Deafness transitory 39.58 13.25 54 1203821 1039 109384385
Basal cell carcinoma 39.56 13.25 703 1203172 44567 109340857
Anaemia macrocytic 39.49 13.25 15 1203860 7288 109378136
Lichenoid keratosis 39.35 13.25 10 1203865 6292 109379132
Bradyarrhythmia 39.32 13.25 4 1203871 4930 109380494
Urinary bladder suspension 39.31 13.25 22 1203853 111 109385313
Alcohol abuse 39.27 13.25 4 1203871 4925 109380499
Portal vein thrombosis 39.00 13.25 14 1203861 7044 109378380
Incorrect product administration duration 38.99 13.25 105 1203770 20393 109365031
Rheumatoid arthritis 38.99 13.25 3778 1200097 295835 109089589
Sleep disorder 38.91 13.25 2585 1201290 196059 109189365
Small intestinal haemorrhage 38.82 13.25 3 1203872 4615 109380809
Subileus 38.71 13.25 11 1203864 6426 109378998
Anal fistula 38.71 13.25 22 1203853 8451 109376973
Escherichia sepsis 38.55 13.25 33 1203842 10239 109375185
Pollakiuria 38.49 13.25 302 1203573 43893 109341531
Intestinal sepsis 38.49 13.25 51 1203824 953 109384471
Restless legs syndrome 38.45 13.25 138 1203737 24488 109360936
Type I hypersensitivity 38.30 13.25 11 1203864 6382 109379042
Inadequate analgesia 38.26 13.25 5 1203870 5072 109380352
Disturbance in social behaviour 38.07 13.25 5 1203870 5053 109380371
Spinal laminectomy 37.99 13.25 46 1203829 782 109384642
Lung transplant 37.98 13.25 6 1203869 5280 109380144
Culture urine positive 37.93 13.25 4 1203871 4792 109380632
Pathological fracture 37.91 13.25 45 1203830 11987 109373437
Communication disorder 37.88 13.25 5 1203870 5034 109380390
Scar excision 37.82 13.25 18 1203857 60 109385364
Device breakage 37.78 13.25 57 1203818 13712 109371712
Alanine aminotransferase abnormal 37.73 13.25 201 1203674 9133 109376291
Embolism venous 37.72 13.25 5 1203870 5018 109380406
Pruritus genital 37.67 13.25 12 1203863 6510 109378914
Pulmonary function test abnormal 37.49 13.25 5 1203870 4995 109380429
Cerebellar syndrome 37.47 13.25 11 1203864 6291 109379133
Intervertebral disc space narrowing 37.36 13.25 71 1203804 1825 109383599
Cytomegalovirus colitis 37.36 13.25 15 1203860 7046 109378378
Infected bite 37.34 13.25 75 1203800 2010 109383414
Diarrhoea haemorrhagic 37.16 13.25 71 1203804 15568 109369856
Nasal discharge discolouration 37.15 13.25 97 1203778 3104 109382320
Sudden cardiac death 37.07 13.25 8 1203867 5629 109379795
Hyperventilation 37.06 13.25 26 1203849 8921 109376503
Initial insomnia 37.05 13.25 35 1203840 10354 109375070
Carotid artery stenosis 36.96 13.25 28 1203847 9235 109376189
Joint ankylosis 36.83 13.25 83 1203792 2414 109383010
Depressive symptom 36.81 13.25 23 1203852 8391 109377033
Haemoperitoneum 36.78 13.25 7 1203868 5381 109380043
Secondary immunodeficiency 36.73 13.25 4 1203871 4672 109380752
Hypopituitarism 36.49 13.25 3 1203872 4387 109381037
Thrombophlebitis 36.45 13.25 19 1203856 7660 109377764
Pulmonary arterial pressure increased 36.43 13.25 6 1203869 5121 109380303
Leukoencephalopathy 36.43 13.25 28 1203847 9167 109376257
Thyroiditis 36.38 13.25 13 1203862 6560 109378864
Skin hyperpigmentation 36.38 13.25 25 1203850 8671 109376753
Vitreous haemorrhage 36.17 13.25 4 1203871 4616 109380808
Sputum increased 36.15 13.25 9 1203866 5742 109379682
Spinal column injury 36.10 13.25 79 1203796 2252 109383172
Lymphocyte percentage decreased 36.03 13.25 7 1203868 5303 109380121
Blood sodium increased 35.99 13.25 8 1203867 5515 109379909
Extravasation 35.96 13.25 5 1203870 4840 109380584
Craniocerebral injury 35.94 13.25 10 1203865 5924 109379500
Menopause 35.93 13.25 83 1203792 2455 109382969
JC virus infection 35.84 13.25 7 1203868 5283 109380141
Nephrogenic anaemia 35.74 13.25 4 1203871 4573 109380851
Prescription drug used without a prescription 35.73 13.25 8 1203867 5488 109379936
Blood thyroid stimulating hormone decreased 35.73 13.25 17 1203858 7222 109378202
Neuralgia 35.68 13.25 346 1203529 48132 109337292
Fungal infection 35.60 13.25 763 1203112 50043 109335381
Muscle twitching 35.58 13.25 186 1203689 29749 109355675
Lacunar infarction 35.54 13.25 12 1203863 6274 109379150
Dysaesthesia 35.49 13.25 15 1203860 6832 109378592
Drug tolerance 35.47 13.25 305 1203570 16280 109369144
Staphylococcus test positive 35.33 13.25 18 1203857 7352 109378072
Lipodystrophy acquired 35.21 13.25 4 1203871 4520 109380904
Product administered to patient of inappropriate age 35.11 13.25 22 1203853 8014 109377410
Therapeutic response shortened 35.06 13.25 184 1203691 29399 109356025
Product preparation error 35.01 13.25 40 1203835 10839 109374585
Conjunctival hyperaemia 35.00 13.25 10 1203865 5821 109379603
Fixed eruption 34.88 13.25 3 1203872 4229 109381195
Papule 34.88 13.25 209 1203666 9924 109375500
Panic attack 34.86 13.25 179 1203696 28761 109356663
Tension headache 34.77 13.25 32 1203843 9586 109375838
Anal haemorrhage 34.74 13.25 6 1203869 4946 109380478
Tendon disorder 34.71 13.25 181 1203694 8156 109377268
Extrasystoles 34.68 13.25 24 1203851 8294 109377130
Oesophageal varices haemorrhage 34.67 13.25 6 1203869 4939 109380485
Bacterial test positive 34.63 13.25 22 1203853 7955 109377469
Blood chloride increased 34.60 13.25 13 1203862 6359 109379065
Enterococcal bacteraemia 34.58 13.25 4 1203871 4457 109380967
Wound dehiscence 34.51 13.25 22 1203853 7940 109377484
Laryngeal pain 34.50 13.25 11 1203864 5964 109379460
Illness 34.22 13.25 1153 1202722 81018 109304406
Endocarditis 34.19 13.25 58 1203817 13313 109372111
Psychiatric symptom 34.09 13.25 30 1203845 9183 109376241
Pyelonephritis acute 34.01 13.25 18 1203857 7195 109378229
Paradoxical drug reaction 33.93 13.25 34 1203841 9783 109375641
Paranasal sinus discomfort 33.88 13.25 149 1203726 6256 109379168
Linear IgA disease 33.86 13.25 4 1203871 4385 109381039
Refusal of treatment by patient 33.84 13.25 32 1203843 9462 109375962
Neurogenic bladder 33.82 13.25 7 1203868 5072 109380352
Anaphylactoid reaction 33.74 13.25 16 1203859 6810 109378614
False positive tuberculosis test 33.71 13.25 12 1203863 13 109385411
Exposure via skin contact 33.65 13.25 57 1203818 13090 109372334
Labelled drug-drug interaction issue 33.54 13.25 3 1203872 4098 109381326
Hepatorenal syndrome 33.53 13.25 5 1203870 4592 109380832
Rhinitis 33.46 13.25 129 1203746 22416 109363008
Ocular icterus 33.46 13.25 12 1203863 6041 109379383
Product physical issue 33.42 13.25 7 1203868 5029 109380395
Pneumomediastinum 33.42 13.25 7 1203868 5029 109380395
Macular oedema 33.41 13.25 17 1203858 6949 109378475
Ingrown hair 33.29 13.25 42 1203833 746 109384678
Epicondylitis 33.29 13.25 81 1203794 2479 109382945
Paraparesis 33.22 13.25 5 1203870 4561 109380863
Oropharyngeal discomfort 33.21 13.25 38 1203837 10289 109375135
Contrast media allergy 33.07 13.25 97 1203778 3326 109382098
Megacolon 33.02 13.25 4 1203871 4301 109381123
Hepatosplenomegaly 33.02 13.25 17 1203858 6902 109378522
Metastases to peritoneum 32.98 13.25 10 1203865 5600 109379824
Acute psychosis 32.95 13.25 7 1203868 4980 109380444
Herpes simplex 32.90 13.25 77 1203798 15687 109369737
Meningitis cryptococcal 32.90 13.25 6 1203869 4756 109380668
Reversible cerebral vasoconstriction syndrome 32.89 13.25 6 1203869 4755 109380669
Embedded device 32.85 13.25 3 1203872 4030 109381394
Autoimmune hepatitis 32.79 13.25 70 1203805 14734 109370690
Disability assessment scale score increased 32.67 13.25 4 1203871 4266 109381158
Injection site hyperaesthesia 32.67 13.25 17 1203858 72 109385352
Hearing aid user 32.66 13.25 15 1203860 45 109385379
Flank pain 32.65 13.25 135 1203740 22995 109362429
Psychiatric decompensation 32.60 13.25 11 1203864 5754 109379670
Blood cholesterol increased 32.58 13.25 2384 1201491 182401 109203023
Vaginal haemorrhage 32.57 13.25 151 1203724 24923 109360501
Hypoproteinaemia 32.50 13.25 12 1203863 5933 109379491
Anticipatory anxiety 32.48 13.25 53 1203822 1203 109384221
Blood glucose decreased 32.43 13.25 188 1203687 29300 109356124
Myoglobin blood increased 32.30 13.25 4 1203871 4228 109381196
Animal scratch 32.26 13.25 66 1203809 1793 109383631
Trigger finger 32.08 13.25 125 1203750 4967 109380457
Mesenteritis 32.08 13.25 29 1203846 344 109385080
Ligament operation 32.01 13.25 14 1203861 36 109385388
Laryngospasm 32.00 13.25 6 1203869 4662 109380762
Phlebitis 31.87 13.25 36 1203839 9805 109375619
Cast application 31.84 13.25 11 1203864 10 109385414
Epidural injection 31.78 13.25 9 1203866 0 109385424
Tonsillar ulcer 31.73 13.25 32 1203843 439 109384985
Thyroid cancer 31.69 13.25 143 1203732 6071 109379353
Rib fracture 31.68 13.25 226 1203649 33544 109351880
Retching 31.64 13.25 133 1203742 22549 109362875
Injection site infection 31.57 13.25 80 1203795 2513 109382911
Chronic respiratory failure 31.54 13.25 3 1203872 3900 109381524
Kidney fibrosis 31.52 13.25 5 1203870 4387 109381037
Dermatitis exfoliative generalised 31.50 13.25 44 1203831 10928 109374496
Optic ischaemic neuropathy 31.45 13.25 4 1203871 4143 109381281
Low density lipoprotein increased 31.40 13.25 42 1203833 10624 109374800
Sputum culture positive 31.40 13.25 3 1203872 3886 109381538
Mouth haemorrhage 31.38 13.25 62 1203813 13426 109371998
Bicytopenia 31.38 13.25 17 1203858 6707 109378717
Visual field defect 31.38 13.25 38 1203837 10034 109375390
Product availability issue 31.29 13.25 24 1203851 7866 109377558
Abnormal dreams 31.26 13.25 57 1203818 12723 109372701
Arthroscopic surgery 31.22 13.25 14 1203861 39 109385385
Ependymoma malignant 31.19 13.25 12 1203863 19 109385405
Psychotic symptom 31.17 13.25 3 1203872 3864 109381560
Pneumonia pseudomonal 31.16 13.25 22 1203853 7524 109377900
Skin papilloma 31.01 13.25 153 1203722 6743 109378681
Metastases to lymph nodes 30.92 13.25 74 1203801 14958 109370466
Pulmonary sarcoidosis 30.85 13.25 63 1203812 1709 109383715
Clostridial infection 30.80 13.25 15 1203860 6287 109379137
Body height decreased 30.69 13.25 42 1203833 10521 109374903
Procalcitonin increased 30.55 13.25 4 1203871 4052 109381372
Compartment syndrome 30.55 13.25 13 1203862 5897 109379527
Transplant rejection 30.52 13.25 405 1203470 24162 109361262
Non-small cell lung cancer 30.39 13.25 25 1203850 7910 109377514
Hereditary angioedema 30.37 13.25 20 1203855 7094 109378330
Ankle arthroplasty 30.33 13.25 78 1203797 2473 109382951
Amyotrophic lateral sclerosis 30.28 13.25 69 1203806 2022 109383402
Sexual dysfunction 30.11 13.25 29 1203846 8501 109376923
Lymph node pain 30.07 13.25 65 1203810 1837 109383587
Upper-airway cough syndrome 30.02 13.25 284 1203591 15573 109369851
Dizziness postural 29.98 13.25 72 1203803 14537 109370887
Pulmonary sepsis 29.97 13.25 10 1203865 5268 109380156
Streptococcal bacteraemia 29.95 13.25 7 1203868 4662 109380762
Tonsillectomy 29.93 13.25 41 1203834 792 109384632
Hepatic lesion 29.83 13.25 29 1203846 8464 109376960
Sunburn 29.76 13.25 113 1203762 4435 109380989
Coronavirus infection 29.75 13.25 36 1203839 9509 109375915
Lyme disease 29.71 13.25 109 1203766 4207 109381217
Adenovirus infection 29.70 13.25 46 1203829 10948 109374476
Nasal ulcer 29.62 13.25 78 1203797 2509 109382915
Mite allergy 29.62 13.25 13 1203862 5790 109379634
Cold sweat 29.62 13.25 131 1203744 21900 109363524
Mean cell haemoglobin increased 29.61 13.25 12 1203863 5605 109379819
Weight fluctuation 29.57 13.25 132 1203743 22013 109363411
Defaecation urgency 29.43 13.25 31 1203844 8716 109376708
Infusion site bruising 29.43 13.25 3 1203872 3691 109381733
Drug effect less than expected 29.37 13.25 22 1203853 7298 109378126
Artificial crown procedure 29.26 13.25 26 1203849 301 109385123
Upper limb fracture 29.21 13.25 352 1203523 20536 109364888
Polycystic ovaries 29.20 13.25 8 1203867 4788 109380636
Subacute cutaneous lupus erythematosus 29.18 13.25 9 1203866 4985 109380439
Focal segmental glomerulosclerosis 29.12 13.25 5 1203870 4140 109381284
Social avoidant behaviour 29.08 13.25 11 1203864 5358 109380066
Seronegative arthritis 29.07 13.25 244 1203631 12933 109372491
Hyperthermia malignant 29.01 13.25 4 1203871 3896 109381528
Prothrombin time shortened 28.94 13.25 3 1203872 3643 109381781
Meningitis aseptic 28.92 13.25 39 1203836 9831 109375593
Self-injurious ideation 28.92 13.25 6 1203869 4340 109381084
Autoimmune haemolytic anaemia 28.75 13.25 44 1203831 10523 109374901
Urine analysis abnormal 28.63 13.25 20 1203855 6877 109378547
Multiple allergies 28.62 13.25 230 1203645 12033 109373391
Malignant pleural effusion 28.62 13.25 5 1203870 4088 109381336
Pancreatitis necrotising 28.60 13.25 12 1203863 5489 109379935
Application site pain 28.58 13.25 12 1203863 5487 109379937
Rhonchi 28.54 13.25 7 1203868 4511 109380913
Dilatation atrial 28.53 13.25 4 1203871 3848 109381576
Affective disorder 28.53 13.25 49 1203826 11192 109374232
Monocyte count decreased 28.53 13.25 4 1203871 3847 109381577
Tetany 28.52 13.25 3 1203872 3601 109381823
Focal dyscognitive seizures 28.51 13.25 4 1203871 3845 109381579
Arthritis infective 28.50 13.25 203 1203672 10226 109375198
Lymphadenopathy 28.46 13.25 903 1202972 62932 109322492
Hepatic enzyme abnormal 28.43 13.25 193 1203682 9570 109375854
Hepatitis B virus test positive 28.39 13.25 32 1203843 502 109384922
Abnormal weight gain 28.39 13.25 3 1203872 3588 109381836
Conduction disorder 28.25 13.25 5 1203870 4050 109381374
Prosthesis user 28.22 13.25 15 1203860 67 109385357
Product administered at inappropriate site 28.18 13.25 125 1203750 5268 109380156
Diffuse alveolar damage 28.18 13.25 5 1203870 4042 109381382
Premature labour 28.16 13.25 35 1203840 9137 109376287
Breast cancer metastatic 28.14 13.25 49 1203826 11132 109374292
Skin reaction 28.14 13.25 353 1203522 20791 109364633
Frustration tolerance decreased 28.11 13.25 177 1203698 8554 109376870
Hypoaesthesia oral 28.08 13.25 93 1203782 16909 109368515
Pneumonia influenzal 28.07 13.25 4 1203871 3801 109381623
Body temperature abnormal 28.05 13.25 86 1203789 3023 109382401
Multiple fractures 28.01 13.25 180 1203695 8760 109376664
Haemorrhoidal haemorrhage 28.01 13.25 28 1203847 8065 109377359
Urinary hesitation 27.94 13.25 8 1203867 4650 109380774
Cystitis 27.86 13.25 928 1202947 65108 109320316
Macular degeneration 27.80 13.25 131 1203744 21528 109363896
Abdominal abscess 27.77 13.25 33 1203842 8786 109376638
Cardiopulmonary failure 27.74 13.25 27 1203848 7876 109377548
Vascular purpura 27.74 13.25 4 1203871 3767 109381657
Polymyalgia rheumatica 27.65 13.25 18 1203857 6424 109379000
Aphthous ulcer 27.62 13.25 127 1203748 21009 109364415
Hyperaesthesia teeth 27.61 13.25 71 1203804 2251 109383173
Pneumonia staphylococcal 27.56 13.25 16 1203859 6075 109379349
Increased appetite 27.53 13.25 78 1203797 14899 109370525
Peripheral venous disease 27.50 13.25 1149 1202726 82968 109302456
Neuritis 27.49 13.25 24 1203851 7375 109378049
Vascular pseudoaneurysm 27.44 13.25 6 1203869 4184 109381240
Reaction to preservatives 27.41 13.25 23 1203852 245 109385179
Strongyloidiasis 27.36 13.25 10 1203865 4976 109380448
Electric shock 27.23 13.25 61 1203814 1767 109383657
Spondylitis 27.20 13.25 214 1203661 11124 109374300
Intra-abdominal haematoma 27.20 13.25 3 1203872 3469 109381955
Anal fissure 27.02 13.25 41 1203834 9840 109375584
Muscle swelling 27.00 13.25 45 1203830 1040 109384384
Neutrophil count abnormal 26.99 13.25 11 1203864 5121 109380303
Device related sepsis 26.99 13.25 26 1203849 7621 109377803
Bursa disorder 26.96 13.25 23 1203852 251 109385173
Gastrointestinal sounds abnormal 26.96 13.25 16 1203859 6002 109379422
Episcleritis 26.94 13.25 49 1203826 1217 109384207
Head discomfort 26.93 13.25 321 1203554 18679 109366745
Anion gap increased 26.92 13.25 7 1203868 4337 109381087
Prostate infection 26.87 13.25 42 1203833 918 109384506
Gastric perforation 26.86 13.25 10 1203865 4919 109380505
Anger 26.79 13.25 111 1203764 18896 109366528
Cartilage injury 26.69 13.25 57 1203818 1597 109383827
Weight bearing difficulty 26.66 13.25 94 1203781 3557 109381867
Troponin T increased 26.57 13.25 7 1203868 4299 109381125
Abnormal faeces 26.56 13.25 37 1203838 9199 109376225
Rocky mountain spotted fever 26.54 13.25 13 1203862 47 109385377
Middle ear effusion 26.53 13.25 77 1203798 2624 109382800
Liver abscess 26.52 13.25 27 1203848 7712 109377712
Peripheral motor neuropathy 26.46 13.25 6 1203869 4080 109381344
Steroid diabetes 26.46 13.25 12 1203863 5242 109380182
Needle issue 26.44 13.25 304 1203571 17536 109367888
Oral infection 26.41 13.25 138 1203737 6223 109379201
Bone density abnormal 26.39 13.25 98 1203777 3805 109381619
Migraine 26.38 13.25 2191 1201684 169461 109215963
Brain abscess 26.37 13.25 21 1203854 6753 109378671
Tumour marker increased 26.36 13.25 11 1203864 5049 109380375
Dilatation ventricular 26.36 13.25 6 1203869 4069 109381355
Arthroscopy 26.24 13.25 34 1203841 621 109384803
Pregnancy 26.18 13.25 735 1203140 50332 109335092
Accident at work 26.12 13.25 48 1203827 1202 109384222
Choking 26.11 13.25 81 1203794 15029 109370395
Tenoplasty 26.09 13.25 20 1203855 185 109385239
Periodontitis 26.06 13.25 12 1203863 5196 109380228
Hypertensive emergency 25.99 13.25 3 1203872 3348 109382076
Oesophageal carcinoma 25.93 13.25 54 1203821 11470 109373954
Peripheral arterial occlusive disease 25.87 13.25 38 1203837 9242 109376182
Carotid artery occlusion 25.86 13.25 40 1203835 9525 109375899
Fibrosis 25.81 13.25 27 1203848 7615 109377809
Acinetobacter infection 25.80 13.25 4 1203871 3569 109381855
Urinary tract obstruction 25.80 13.25 12 1203863 5165 109380259
Right ventricular dysfunction 25.71 13.25 3 1203872 3320 109382104
Venous injury 25.66 13.25 42 1203833 956 109384468
Liver transplant 25.53 13.25 9 1203866 4580 109380844
Local reaction 25.52 13.25 37 1203838 755 109384669
Hyperparathyroidism secondary 25.52 13.25 3 1203872 3301 109382123
Gastric infection 25.49 13.25 103 1203772 4163 109381261
Injection site erosion 25.47 13.25 19 1203856 168 109385256
Calciphylaxis 25.47 13.25 7 1203868 4180 109381244
Metastases to meninges 25.38 13.25 12 1203863 5116 109380308
Gastrointestinal stoma complication 25.37 13.25 3 1203872 3286 109382138
Ovarian cancer 25.36 13.25 105 1203770 4291 109381133
Oesophageal pain 25.35 13.25 12 1203863 5113 109380311
Nephrolithiasis 25.31 13.25 920 1202955 65292 109320132
Injection site cellulitis 25.30 13.25 63 1203812 1957 109383467
Ligament disorder 25.26 13.25 27 1203848 398 109385026
Normocytic anaemia 25.23 13.25 20 1203855 6447 109378977
Sensitisation 25.13 13.25 7 1203868 4144 109381280
Sensory disturbance 25.06 13.25 101 1203774 17328 109368096
Drug eruption 24.97 13.25 763 1203112 52896 109332528
Ototoxicity 24.95 13.25 7 1203868 4124 109381300
Varices oesophageal 24.93 13.25 25 1203850 7190 109378234
Malabsorption 24.91 13.25 20 1203855 6405 109379019
Quadriparesis 24.90 13.25 10 1203865 4697 109380727
Dry skin 24.87 13.25 939 1202936 106714 109278710
Paronychia 24.87 13.25 52 1203823 11029 109374395
Large intestinal ulcer 24.86 13.25 16 1203859 5745 109379679
Cholecystectomy 24.83 13.25 202 1203673 10607 109374817
Pharyngeal oedema 24.82 13.25 281 1203594 16147 109369277
Hepatitis toxic 24.80 13.25 17 1203858 5904 109379520
Facial paralysis 24.73 13.25 158 1203717 24056 109361368
Mycobacterium tuberculosis complex test 24.72 13.25 7 1203868 0 109385424
Polychondritis 24.67 13.25 40 1203835 903 109384521
Visual impairment 24.67 13.25 1740 1202135 132688 109252736
Obesity 24.55 13.25 1488 1202387 111863 109273561
Urinary tract infection bacterial 24.54 13.25 31 1203844 8036 109377388
Peptic ulcer 24.54 13.25 28 1203847 7591 109377833
Pre-eclampsia 24.53 13.25 35 1203840 8615 109376809
Mucous stools 24.49 13.25 23 1203852 6824 109378600
Hyperleukocytosis 24.49 13.25 4 1203871 3435 109381989
Optic neuropathy 24.47 13.25 10 1203865 4648 109380776
Hot flush 24.38 13.25 540 1203335 65496 109319928
Immunisation 24.31 13.25 3 1203872 3180 109382244
Haemoglobin abnormal 24.24 13.25 38 1203837 9000 109376424
Blood parathyroid hormone increased 24.21 13.25 8 1203867 4240 109381184
Adrenocortical insufficiency acute 24.21 13.25 9 1203866 4431 109380993
Gastric bypass 24.14 13.25 51 1203824 1418 109384006
Dactylitis 24.07 13.25 99 1203776 4034 109381390
Spinal cord compression 24.05 13.25 28 1203847 7524 109377900
Mucosal disorder 24.00 13.25 9 1203866 4408 109381016
Miliaria 23.99 13.25 60 1203815 1869 109383555
Adrenal insufficiency 23.96 13.25 321 1203554 42069 109343355
Parathyroid disorder 23.92 13.25 33 1203842 642 109384782
Exposed bone in jaw 23.89 13.25 6 1203869 3805 109381619
Intervertebral disc disorder 23.87 13.25 121 1203754 5391 109380033
Manufacturing product shipping issue 23.87 13.25 15 1203860 97 109385327
Dyschezia 23.85 13.25 6 1203869 3801 109381623
Neck deformity 23.81 13.25 59 1203816 1827 109383597
Product use complaint 23.81 13.25 6 1203869 3797 109381627
Extremity necrosis 23.80 13.25 6 1203869 3796 109381628
Precancerous cells present 23.74 13.25 47 1203828 1246 109384178
Acute abdomen 23.74 13.25 4 1203871 3357 109382067
Amenorrhoea 23.64 13.25 40 1203835 9191 109376233
Urinary tract infection 23.60 13.25 3151 1200724 323131 109062293
Venous thrombosis limb 23.58 13.25 14 1203861 5251 109380173
Hepatic cyst 23.58 13.25 30 1203845 7753 109377671
Superinfection 23.54 13.25 17 1203858 5746 109379678
Procedural haemorrhage 23.52 13.25 15 1203860 5412 109380012
Immobile 23.48 13.25 154 1203721 7548 109377876
Staphylococcal infection 23.46 13.25 958 1202917 68986 109316438
Thrombocytosis 23.45 13.25 49 1203826 10395 109375029
Device defective 23.41 13.25 93 1203782 3729 109381695
Idiopathic intracranial hypertension 23.31 13.25 7 1203868 3945 109381479
Tendon sheath incision 23.26 13.25 11 1203864 36 109385388
Peripheral sensorimotor neuropathy 23.23 13.25 7 1203868 3936 109381488
Laryngeal disorder 23.20 13.25 44 1203831 1129 109384295
Injection site plaque 23.18 13.25 18 1203857 170 109385254
Investigation abnormal 23.16 13.25 69 1203806 2387 109383037
Eructation 23.14 13.25 77 1203798 13980 109371444
Premature baby 23.06 13.25 12 1203863 4843 109380581
Diabetic nephropathy 23.02 13.25 5 1203870 3503 109381921
Paresis 22.97 13.25 12 1203863 4832 109380592
Angle closure glaucoma 22.94 13.25 5 1203870 3494 109381930
Polydipsia 22.92 13.25 30 1203845 7658 109377766
Mean cell haemoglobin concentration decreased 22.90 13.25 17 1203858 5665 109379759
Ileal stenosis 22.85 13.25 4 1203871 3266 109382158
Jugular vein thrombosis 22.85 13.25 15 1203860 5330 109380094
Subcutaneous haematoma 22.85 13.25 3 1203872 3033 109382391
Ulcer 22.79 13.25 623 1203252 42493 109342931
Bone deformity 22.70 13.25 24 1203851 349 109385075
Dysstasia 22.67 13.25 494 1203381 32492 109352932
Unintended pregnancy 22.67 13.25 12 1203863 4796 109380628
Mammoplasty 22.63 13.25 26 1203849 417 109385007
Gastric operation 22.61 13.25 23 1203852 319 109385105
Pruritus allergic 22.59 13.25 54 1203821 1634 109383790
Spinal compression fracture 22.58 13.25 113 1203762 18279 109367145
Folate deficiency 22.56 13.25 10 1203865 4428 109380996
Device deployment issue 22.56 13.25 9 1203866 4244 109381180
Tonsillitis 22.53 13.25 160 1203715 8053 109377371
Hepatitis B reactivation 22.52 13.25 29 1203846 7455 109377969
Hypokinesia 22.51 13.25 142 1203733 21684 109363740
Viral infection 22.47 13.25 747 1203128 52392 109333032
Body tinea 22.44 13.25 62 1203813 2053 109383371
Enterocolitis infectious 22.42 13.25 5 1203870 3439 109381985
Cytology abnormal 22.38 13.25 23 1203852 323 109385101
Central venous catheterisation 22.31 13.25 7 1203868 3835 109381589
Ankle fracture 22.30 13.25 321 1203554 19498 109365926
Aortic dissection 22.26 13.25 13 1203862 4920 109380504
Hypersensitivity pneumonitis 22.21 13.25 15 1203860 5250 109380174
Infiltration anaesthesia 22.20 13.25 17 1203858 157 109385267
Internal haemorrhage 21.99 13.25 48 1203827 10023 109375401
Chronic disease 21.94 13.25 19 1203856 212 109385212
Infected cyst 21.89 13.25 48 1203827 1370 109384054
Breast cancer stage I 21.84 13.25 29 1203846 7358 109378066
Resuscitation 21.83 13.25 3 1203872 2930 109382494
Presbyacusis 21.82 13.25 74 1203801 2745 109382679
Mallory-Weiss syndrome 21.80 13.25 4 1203871 3157 109382267
Hyporeflexia 21.74 13.25 9 1203866 4151 109381273
Klebsiella sepsis 21.68 13.25 9 1203866 4144 109381280
PO2 decreased 21.68 13.25 4 1203871 3144 109382280
Limb crushing injury 21.61 13.25 20 1203855 245 109385179
Diabetic retinopathy 21.60 13.25 6 1203869 3558 109381866
Red blood cells urine positive 21.57 13.25 15 1203860 5170 109380254
Enterococcus test positive 21.55 13.25 3 1203872 2901 109382523
Trismus 21.50 13.25 24 1203851 6572 109378852
Limb mass 21.50 13.25 93 1203782 3876 109381548
Adjustment disorder with depressed mood 21.50 13.25 628 1203247 43255 109342169
Whipple's disease 21.45 13.25 8 1203867 11 109385413
Compression fracture 21.41 13.25 43 1203832 9256 109376168
Autoimmune disorder 21.30 13.25 894 1202981 64589 109320835
Burns second degree 21.23 13.25 32 1203843 7701 109377723
Acute graft versus host disease in skin 21.20 13.25 54 1203821 10686 109374738
Enuresis 21.19 13.25 9 1203866 4087 109381337
Accident 21.16 13.25 197 1203678 10755 109374669
Metabolic surgery 21.15 13.25 48 1203827 1403 109384021
Sensitive skin 21.14 13.25 7 1203868 3705 109381719
Intracardiac thrombus 21.10 13.25 10 1203865 4258 109381166
Disorganised speech 21.09 13.25 5 1203870 3298 109382126
Musculoskeletal injury 21.06 13.25 18 1203857 197 109385227
Gastrointestinal oedema 21.05 13.25 5 1203870 3293 109382131
Thinking abnormal 20.98 13.25 89 1203786 15051 109370373
Ear disorder 20.95 13.25 107 1203768 4782 109380642
Tic 20.95 13.25 6 1203869 3487 109381937
Enteritis infectious 20.95 13.25 8 1203867 3874 109381550
Bladder repair 20.92 13.25 12 1203863 64 109385360
Retinitis 20.91 13.25 480 1203395 31847 109353577
Biliary colic 20.91 13.25 12 1203863 4585 109380839
Hypertensive heart disease 20.90 13.25 12 1203863 4584 109380840
Antinuclear antibody positive 20.88 13.25 171 1203704 8997 109376427
Substance-induced psychotic disorder 20.88 13.25 17 1203858 5407 109380017
Antibody test positive 20.81 13.25 78 1203797 3042 109382382
X-ray abnormal 20.78 13.25 553 1203322 37564 109347860
Bone lesion 20.77 13.25 28 1203847 7059 109378365
Antineutrophil cytoplasmic antibody positive 20.70 13.25 15 1203860 5061 109380363
Differentiation syndrome 20.68 13.25 4 1203871 3040 109382384
Monoparesis 20.54 13.25 12 1203863 4541 109380883
Cystoid macular oedema 20.53 13.25 3 1203872 2797 109382627
Chorea 20.46 13.25 5 1203870 3230 109382194
Dental caries 20.45 13.25 221 1203654 12552 109372872
Bipolar disorder 20.44 13.25 42 1203833 8965 109376459
Extranodal marginal zone B-cell lymphoma (MALT type) 20.42 13.25 33 1203842 743 109384681
Hypercalcaemia 20.39 13.25 371 1203504 46286 109339138
Eyelid oedema 20.36 13.25 91 1203784 15171 109370253
Intra-abdominal fluid collection 20.35 13.25 8 1203867 3806 109381618
Product preparation issue 20.32 13.25 3 1203872 2776 109382648
Oligohydramnios 20.30 13.25 9 1203866 3985 109381439
Livedo reticularis 20.29 13.25 18 1203857 5488 109379936
Terminal state 20.22 13.25 118 1203757 5549 109379875
Loss of employment 20.19 13.25 81 1203794 3263 109382161
Pelvic venous thrombosis 20.17 13.25 3 1203872 2761 109382663
Galactorrhoea 20.14 13.25 10 1203865 4145 109381279
Hypochromic anaemia 20.14 13.25 5 1203870 3196 109382228
Intervertebral disc compression 20.12 13.25 46 1203829 1351 109384073
Bruxism 20.05 13.25 15 1203860 4979 109380445
Large intestinal stenosis 20.05 13.25 8 1203867 3772 109381652
CD4 lymphocytes decreased 20.01 13.25 4 1203871 2970 109382454
Maternal exposure before pregnancy 20.01 13.25 30 1203845 7235 109378189
Eastern Cooperative Oncology Group performance status worsened 19.96 13.25 4 1203871 2965 109382459
Tumour pain 19.94 13.25 4 1203871 2963 109382461
Synovial disorder 19.92 13.25 75 1203800 2932 109382492
Microcytic anaemia 19.86 13.25 23 1203852 6195 109379229
Injection site streaking 19.84 13.25 10 1203865 39 109385385
Bursa removal 19.84 13.25 9 1203866 26 109385398
White blood cells urine positive 19.83 13.25 32 1203843 7492 109377932
Epstein-Barr virus associated lymphoproliferative disorder 19.83 13.25 14 1203861 4788 109380636
Hepatitis E 19.77 13.25 12 1203863 4447 109380977
Limb injury 19.66 13.25 543 1203332 37093 109348331
Haemoglobin increased 19.64 13.25 44 1203831 9103 109376321
Myelopathy 19.63 13.25 19 1203856 5557 109379867
Spinal nerve stimulator implantation 19.60 13.25 14 1203861 115 109385309
Apraxia 19.60 13.25 7 1203868 3533 109381891
Stillbirth 19.58 13.25 11 1203864 4253 109381171
Hostility 19.51 13.25 3 1203872 2693 109382731
Movement disorder 19.39 13.25 279 1203596 36125 109349299
Bladder operation 19.35 13.25 39 1203836 1048 109384376
Blood creatine phosphokinase MB increased 19.34 13.25 4 1203871 2899 109382525
Urine abnormality 19.33 13.25 44 1203831 9052 109376372
Rash macular 19.33 13.25 555 1203320 38131 109347293
Nail operation 19.32 13.25 51 1203824 1643 109383781
Diverticulum 19.29 13.25 95 1203780 15431 109369993
Squamous cell carcinoma of skin 19.28 13.25 109 1203766 17094 109368330
Skin atrophy 19.26 13.25 130 1203745 6434 109378990
Hepatocellular carcinoma 19.26 13.25 50 1203825 9830 109375594
Mechanical ventilation 19.25 13.25 6 1203869 3301 109382123
Dysphoria 19.24 13.25 25 1203850 6403 109379021
Muscular weakness 19.24 13.25 2389 1201486 246079 109139345
Strabismus 19.23 13.25 7 1203868 3492 109381932
Injection site scab 19.12 13.25 29 1203846 617 109384807
Regurgitation 19.11 13.25 7 1203868 3478 109381946
Small intestinal perforation 19.09 13.25 12 1203863 4364 109381060
Hodgkin's disease 19.07 13.25 33 1203842 787 109384637
Fracture 19.06 13.25 175 1203700 24613 109360811
Bronchial obstruction 19.01 13.25 5 1203870 3074 109382350
Unmasking of previously unidentified disease 19.00 13.25 4 1203871 2864 109382560
Organising pneumonia 18.96 13.25 85 1203790 14158 109371266
Glycosuria 18.86 13.25 3 1203872 2627 109382797
Varicella zoster virus infection 18.83 13.25 25 1203850 6343 109379081
Nail discolouration 18.80 13.25 84 1203791 3551 109381873
Injection site discharge 18.78 13.25 46 1203829 1414 109384010
Skin necrosis 18.77 13.25 334 1203541 21178 109364246
Chronic graft versus host disease in skin 18.76 13.25 3 1203872 2616 109382808
Hypertonic bladder 18.75 13.25 18 1203857 5284 109380140
Coronary artery occlusion 18.74 13.25 98 1203777 15674 109369750
Tendon injury 18.71 13.25 64 1203811 2385 109383039
Pneumoperitoneum 18.70 13.25 10 1203865 3974 109381450
Paraplegia 18.68 13.25 24 1203851 6176 109379248
Organ failure 18.67 13.25 15 1203860 4802 109380622
Pulmonary infarction 18.65 13.25 11 1203864 4140 109381284
Toxoplasmosis 18.63 13.25 6 1203869 3233 109382191
Pulse abnormal 18.63 13.25 11 1203864 4138 109381286
Haematocrit increased 18.53 13.25 16 1203859 4943 109380481
Abdominal operation 18.51 13.25 34 1203841 851 109384573
Oesophageal candidiasis 18.43 13.25 64 1203811 11470 109373954
Wisdom teeth removal 18.41 13.25 32 1203843 766 109384658
Gastrointestinal inflammation 18.39 13.25 48 1203827 9421 109376003
Genital abscess 18.37 13.25 19 1203856 269 109385155
Epstein-Barr viraemia 18.30 13.25 8 1203867 3571 109381853
Guillain-Barre syndrome 18.28 13.25 58 1203817 10686 109374738
Laser therapy 18.18 13.25 8 1203867 21 109385403
Generalised anxiety disorder 18.16 13.25 4 1203871 2775 109382649
Limb reconstructive surgery 18.10 13.25 10 1203865 49 109385375
Gingival injury 18.08 13.25 9 1203866 34 109385390
International normalised ratio fluctuation 18.06 13.25 11 1203864 4069 109381355
Faeces hard 18.04 13.25 12 1203863 4234 109381190
Abdominal tenderness 18.03 13.25 72 1203803 12385 109373039
Renal artery stenosis 18.01 13.25 9 1203866 3717 109381707
Infectious pleural effusion 18.01 13.25 16 1203859 4875 109380549
Monoclonal immunoglobulin present 17.99 13.25 3 1203872 2537 109382887
Mycotic allergy 17.99 13.25 23 1203852 5931 109379493
Pneumocystis jirovecii infection 17.95 13.25 13 1203862 4387 109381037
Pelvic pain 17.87 13.25 101 1203774 15841 109369583
Anti-cyclic citrullinated peptide antibody 17.79 13.25 311 1203564 19653 109365771
Malignant neoplasm of conjunctiva 17.77 13.25 11 1203864 69 109385355
Ischaemic cerebral infarction 17.77 13.25 5 1203870 2940 109382484
Upper respiratory tract inflammation 17.72 13.25 13 1203862 4358 109381066
Tongue biting 17.71 13.25 5 1203870 2934 109382490
Hypercoagulation 17.70 13.25 7 1203868 3319 109382105
Pleuritic pain 17.70 13.25 103 1203772 16037 109369387
Loss of libido 17.68 13.25 6 1203869 3127 109382297
Idiopathic pulmonary fibrosis 17.68 13.25 17 1203858 4987 109380437
Rheumatoid nodule removal 17.66 13.25 5 1203870 0 109385424
Neurectomy 17.66 13.25 5 1203870 0 109385424
Flat affect 17.65 13.25 3 1203872 2502 109382922
Overwork 17.63 13.25 10 1203865 52 109385372
Suicidal behaviour 17.59 13.25 8 1203867 3489 109381935
Prolonged labour 17.58 13.25 24 1203851 462 109384962
Metastasis 17.56 13.25 40 1203835 8227 109377197
Coagulation time prolonged 17.51 13.25 5 1203870 2912 109382512
Injection related reaction 17.49 13.25 47 1203828 1531 109383893
Rebound psoriasis 17.45 13.25 17 1203858 223 109385201
Disease susceptibility 17.40 13.25 20 1203855 321 109385103
Uterine dilation and curettage 17.34 13.25 28 1203847 630 109384794
Gastrointestinal motility disorder 17.31 13.25 33 1203842 7243 109378181
Biliary obstruction 17.28 13.25 21 1203854 5537 109379887
Ejection fraction abnormal 17.27 13.25 8 1203867 3452 109381972
Spinal meningioma benign 17.26 13.25 12 1203863 94 109385330
Lupus vasculitis 17.25 13.25 27 1203848 591 109384833
Scedosporium infection 17.19 13.25 3 1203872 2455 109382969
Tonic convulsion 17.15 13.25 6 1203869 3068 109382356
Application site rash 17.12 13.25 3 1203872 2447 109382977
Muscle atrophy 17.11 13.25 80 1203795 13174 109372250
Mole excision 17.10 13.25 16 1203859 199 109385225
Device alarm issue 17.08 13.25 3 1203872 2443 109382981
Metapneumovirus infection 17.06 13.25 3 1203872 2441 109382983
Urine leukocyte esterase positive 17.05 13.25 10 1203865 3776 109381648
Bite 17.02 13.25 27 1203848 598 109384826
Capillaritis 17.01 13.25 3 1203872 2436 109382988
Anaesthetic complication 17 13.25 9 1203866 3597 109381827
Retinal toxicity 16.98 13.25 48 1203827 1611 109383813
Deep vein thrombosis postoperative 16.98 13.25 799 1203076 58492 109326932
Nail psoriasis 16.96 13.25 29 1203846 685 109384739
Hyperaemia 16.95 13.25 10 1203865 3763 109381661
Pleural fibrosis 16.89 13.25 92 1203783 4216 109381208
Allergic oedema 16.86 13.25 34 1203841 914 109384510
Post procedural haematoma 16.84 13.25 4 1203871 2635 109382789
Biliary dyskinesia 16.84 13.25 3 1203872 2418 109383006
Retinal detachment 16.81 13.25 63 1203812 11037 109374387
Torticollis 16.79 13.25 7 1203868 3214 109382210
Retinal artery occlusion 16.76 13.25 13 1203862 4236 109381188
Epstein-Barr virus infection reactivation 16.74 13.25 12 1203863 4072 109381352
Neuroma 16.72 13.25 19 1203856 301 109385123
Mucosal erosion 16.66 13.25 5 1203870 2819 109382605
Urinary bladder haemorrhage 16.64 13.25 5 1203870 2817 109382607
Malignant melanoma stage I 16.62 13.25 14 1203861 150 109385274
Contrast media reaction 16.61 13.25 3 1203872 2395 109383029
Oesophageal stenosis 16.61 13.25 19 1203856 5146 109380278
Multi-organ disorder 16.60 13.25 8 1203867 3373 109382051
Thyroid operation 16.54 13.25 16 1203859 208 109385216
Body temperature increased 16.51 13.25 461 1203414 54252 109331172
Bronchial hyperreactivity 16.48 13.25 9 1203866 3535 109381889
Splenic infarction 16.48 13.25 14 1203861 4360 109381064
Peripheral coldness 16.47 13.25 126 1203749 18414 109367010
Haemophilus infection 16.44 13.25 5 1203870 2795 109382629
Human herpesvirus 6 infection 16.42 13.25 29 1203846 6552 109378872
Alcoholism 16.40 13.25 10 1203865 3697 109381727
Renal stone removal 16.39 13.25 15 1203860 181 109385243
Anal abscess 16.38 13.25 68 1203807 11570 109373854
Hyperphagia 16.37 13.25 9 1203866 3522 109381902
Gastritis haemorrhagic 16.37 13.25 7 1203868 3166 109382258
Bile duct stone 16.34 13.25 27 1203848 6262 109379162
Subcutaneous emphysema 16.33 13.25 4 1203871 2580 109382844
Osteoporosis postmenopausal 16.30 13.25 9 1203866 44 109385380
Platelet count abnormal 16.30 13.25 27 1203848 6255 109379169
Large intestine polyp 16.29 13.25 97 1203778 15020 109370404
Skin sensitisation 16.29 13.25 37 1203838 1082 109384342
Spinal fusion acquired 16.28 13.25 12 1203863 104 109385320
Melkersson-Rosenthal syndrome 16.28 13.25 7 1203868 17 109385407
Parathyroid gland operation 16.28 13.25 7 1203868 17 109385407
Vaginal operation 16.19 13.25 6 1203869 8 109385416
Enterovirus infection 16.17 13.25 5 1203870 2765 109382659
Extremity contracture 16.16 13.25 49 1203826 1712 109383712
Thymoma benign 16.15 13.25 9 1203866 45 109385379
Prostate cancer metastatic 16.10 13.25 18 1203857 4925 109380499
Large intestinal haemorrhage 16.07 13.25 7 1203868 3132 109382292
Tinea pedis 16.06 13.25 68 1203807 2807 109382617
Suspected COVID-19 16.06 13.25 9 1203866 3484 109381940
Scarlet fever 15.97 13.25 14 1203861 159 109385265
Skin candida 15.94 13.25 3 1203872 2325 109383099
Synovectomy 15.93 13.25 17 1203858 250 109385174
Septic embolus 15.92 13.25 3 1203872 2323 109383101
Ear discomfort 15.92 13.25 190 1203685 11059 109374365
Ulcerative duodenitis 15.91 13.25 8 1203867 31 109385393
Libido increased 15.91 13.25 4 1203871 2535 109382889
Cutaneous T-cell lymphoma 15.88 13.25 76 1203799 3308 109382116
Ureteric obstruction 15.86 13.25 7 1203868 3107 109382317
Essential hypertension 15.85 13.25 39 1203836 7808 109377616
Smear cervix abnormal 15.82 13.25 65 1203810 2647 109382777
Urinary sediment present 15.81 13.25 4 1203871 2524 109382900
Blood glucose fluctuation 15.75 13.25 38 1203837 7660 109377764
Optic atrophy 15.74 13.25 4 1203871 2517 109382907
Biliary dilatation 15.74 13.25 10 1203865 3615 109381809
Stem cell transplant 15.69 13.25 15 1203860 4412 109381012
Tracheobronchitis 15.68 13.25 5 1203870 2711 109382713
Angiopathy 15.66 13.25 46 1203829 8684 109376740
Cerebral venous sinus thrombosis 15.56 13.25 6 1203869 2889 109382535
Plantar fasciitis 15.55 13.25 102 1203773 4999 109380425
Tearfulness 15.53 13.25 36 1203839 7359 109378065
Serum sickness 15.53 13.25 15 1203860 4391 109381033
Crying 15.50 13.25 377 1203498 25251 109360173
Precancerous skin lesion 15.49 13.25 46 1203829 1588 109383836
Recurrent cancer 15.48 13.25 9 1203866 3414 109382010
Hair disorder 15.45 13.25 38 1203837 1171 109384253
Foaming at mouth 15.39 13.25 3 1203872 2267 109383157
Prinzmetal angina 15.38 13.25 3 1203872 2266 109383158
Large intestinal obstruction 15.36 13.25 12 1203863 3896 109381528
Papilloma excision 15.34 13.25 5 1203870 3 109385421
Skin erosion 15.33 13.25 25 1203850 5829 109379595
Epidermal necrosis 15.31 13.25 7 1203868 3043 109382381
Gingival bleeding 15.28 13.25 140 1203735 19699 109365725
Nephritis 15.28 13.25 27 1203848 6099 109379325
Vitreous detachment 15.22 13.25 5 1203870 2660 109382764
Thrombocytopenic purpura 15.21 13.25 7 1203868 3032 109382392
Pancreatic carcinoma 15.21 13.25 97 1203778 14775 109370649
Maternal exposure timing unspecified 15.18 13.25 317 1203558 20696 109364728
Pre-existing condition improved 15.18 13.25 30 1203845 6496 109378928
Intermenstrual bleeding 15.18 13.25 33 1203842 6901 109378523
Jaw clicking 15.14 13.25 11 1203864 93 109385331
Drug specific antibody 15.12 13.25 66 1203809 2762 109382662
General physical condition abnormal 15.11 13.25 38 1203837 7552 109377872
Dermatitis psoriasiform 15.09 13.25 79 1203796 3565 109381859
Cortisol decreased 15.04 13.25 6 1203869 2830 109382594
Streptococcal infection 15.00 13.25 183 1203692 10707 109374717
Uterine cancer 14.95 13.25 87 1203788 4087 109381337
Vocal cord paralysis 14.93 13.25 7 1203868 2999 109382425
Nasal obstruction 14.88 13.25 9 1203866 3341 109382083
Blood potassium abnormal 14.87 13.25 13 1203862 3992 109381432
Traumatic haematoma 14.81 13.25 4 1203871 2417 109383007
Metastases to spine 14.78 13.25 22 1203853 5321 109380103
Cardiac granuloma 14.76 13.25 5 1203870 4 109385420
Transaminases abnormal 14.75 13.25 33 1203842 955 109384469
Dry eye 14.75 13.25 746 1203129 55047 109330377
Discouragement 14.70 13.25 3 1203872 2195 109383229
Computerised tomogram thorax abnormal 14.69 13.25 6 1203869 2789 109382635
Enterocolitis haemorrhagic 14.67 13.25 5 1203870 2599 109382825
Labelled drug-disease interaction medication error 14.66 13.25 19 1203856 347 109385077
Quadriplegia 14.60 13.25 14 1203861 4113 109381311
Hypogeusia 14.59 13.25 3 1203872 2184 109383240
Sinus pain 14.58 13.25 26 1203849 5853 109379571
Nervous system disorder 14.57 13.25 250 1203625 31471 109353953
Aortic thrombosis 14.56 13.25 3 1203872 2180 109383244
Psoriasis area severity index increased 14.54 13.25 17 1203858 278 109385146
Prostatic operation 14.46 13.25 19 1203856 352 109385072
Lymphoedema 14.45 13.25 99 1203776 14830 109370594
Viraemia 14.42 13.25 14 1203861 4088 109381336
Pharyngeal operation 14.41 13.25 6 1203869 13 109385411
Cardiovascular insufficiency 14.37 13.25 9 1203866 3279 109382145
Intervertebral disc injury 14.36 13.25 15 1203860 215 109385209
Vulvovaginal candidiasis 14.34 13.25 9 1203866 3276 109382148
Facial paresis 14.31 13.25 28 1203847 6085 109379339
Chronic gastritis 14.28 13.25 23 1203852 5388 109380036
Spinal rod insertion 14.25 13.25 5 1203870 5 109385419
Yolk sac tumour site unspecified 14.25 13.25 5 1203870 5 109385419
Norovirus infection 14.24 13.25 4 1203871 2355 109383069
Product container seal issue 14.21 13.25 12 1203863 129 109385295
Intentional underdose 14.21 13.25 5 1203870 2547 109382877
Product taste abnormal 14.21 13.25 5 1203870 2547 109382877
Pseudomonas test positive 14.20 13.25 4 1203871 2350 109383074
Dermatitis allergic 14.19 13.25 323 1203552 21401 109364023
Oral pain 14.17 13.25 305 1203570 37139 109348285
Alpha haemolytic streptococcal infection 14.16 13.25 11 1203864 3582 109381842
Gene mutation 14.16 13.25 10 1203865 3419 109382005
Peritoneal dialysis complication 14.15 13.25 5 1203870 2541 109382883
Venomous sting 14.13 13.25 4 1203871 0 109385424
Peripheral vascular disorder 14.10 13.25 47 1203828 8529 109376895
Infectious mononucleosis 14.09 13.25 55 1203820 2187 109383237
Escherichia test positive 14.09 13.25 11 1203864 3573 109381851
Thyroidectomy 14.06 13.25 35 1203840 1087 109384337
Coronary artery thrombosis 14.01 13.25 9 1203866 3235 109382189
Blepharospasm 14.01 13.25 731 1203144 54120 109331304
Blood cholesterol decreased 14.00 13.25 6 1203869 2710 109382714
Biopsy breast 13.99 13.25 12 1203863 132 109385292
Butterfly rash 13.99 13.25 53 1203822 2078 109383346
Cauda equina syndrome 13.98 13.25 3 1203872 2119 109383305
Erosive oesophagitis 13.97 13.25 8 1203867 3061 109382363
Acute febrile neutrophilic dermatosis 13.97 13.25 20 1203855 4916 109380508
Diabetic neuropathy 13.97 13.25 35 1203840 6964 109378460
Dental prosthesis user 13.95 13.25 7 1203868 27 109385397
Enterocutaneous fistula 13.91 13.25 4 1203871 2319 109383105
Discontinued product administered 13.91 13.25 11 1203864 107 109385317
Dermatitis 13.91 13.25 216 1203659 27621 109357803
Acute sinusitis 13.89 13.25 22 1203853 5189 109380235
Pulmonary granuloma 13.87 13.25 60 1203815 2501 109382923
Penile squamous cell carcinoma 13.87 13.25 9 1203866 62 109385362
Peripheral artery thrombosis 13.84 13.25 14 1203861 4010 109381414
Cerebrovascular disorder 13.83 13.25 12 1203863 3699 109381725
Weber tuning fork test abnormal 13.83 13.25 11 1203864 108 109385316
Foetal growth restriction 13.82 13.25 8 1203867 3042 109382382
Non-small cell lung cancer stage II 13.78 13.25 5 1203870 6 109385418
Opportunistic infection 13.77 13.25 11 1203864 3532 109381892
Malignant respiratory tract neoplasm 13.76 13.25 7 1203868 28 109385396
Blood creatinine decreased 13.74 13.25 52 1203823 9085 109376339
Needle track marks 13.72 13.25 10 1203865 85 109385339
Nail bed disorder 13.72 13.25 18 1203857 333 109385091
Bronchial wall thickening 13.71 13.25 9 1203866 3198 109382226
Laboratory test abnormal 13.71 13.25 599 1203276 43480 109341944
Metastatic bronchial carcinoma 13.68 13.25 19 1203856 372 109385052
Biopsy 13.66 13.25 27 1203848 715 109384709
Accidental exposure to product by child 13.64 13.25 9 1203866 3189 109382235
Injection site pallor 13.64 13.25 9 1203866 64 109385360
Hypermobility syndrome 13.64 13.25 23 1203852 537 109384887
Rheumatic disorder 13.62 13.25 76 1203799 3515 109381909
Osteosclerosis 13.59 13.25 90 1203785 4425 109380999
Faeces pale 13.59 13.25 10 1203865 3347 109382077
Infective exacerbation of chronic obstructive airways disease 13.57 13.25 9 1203866 3181 109382243
Product quality issue 13.57 13.25 695 1203180 76604 109308820
Hypothalamo-pituitary disorder 13.57 13.25 7 1203868 2839 109382585
Immune recovery uveitis 13.57 13.25 12 1203863 138 109385286
Eyelid exfoliation 13.56 13.25 17 1203858 300 109385124
Carbon dioxide increased 13.55 13.25 7 1203868 2837 109382587
Secondary adrenocortical insufficiency 13.53 13.25 17 1203858 4417 109381007
Synovial rupture 13.53 13.25 22 1203853 498 109384926
Retinopathy 13.49 13.25 17 1203858 4412 109381012
Labile blood pressure 13.49 13.25 5 1203870 2466 109382958
Proteus infection 13.42 13.25 7 1203868 2821 109382603
Disease complication 13.37 13.25 27 1203848 5800 109379624
Rectal tenesmus 13.36 13.25 4 1203871 2258 109383166
Hair colour changes 13.35 13.25 19 1203856 4682 109380742
Septic arthritis staphylococcal 13.35 13.25 30 1203845 871 109384553
Infarction 13.34 13.25 23 1203852 5246 109380178
Micturition disorder 13.33 13.25 19 1203856 4679 109380745
Blood alkaline phosphatase decreased 13.33 13.25 5 1203870 2448 109382976
Papilloedema 13.32 13.25 39 1203836 7370 109378054
Red cell distribution width decreased 13.30 13.25 54 1203821 2187 109383237

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AB01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Tumor necrosis factor alpha (TNF-alpha) inhibitors
FDA MoA N0000175451 Tumor Necrosis Factor Receptor Blocking Activity
MeSH PA D000700 Analgesics
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018712 Analgesics, Non-Narcotic
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:233423 antifibrotic agent
FDA EPC N0000175610 Tumor Necrosis Factor Blocker

Related Drugs by ATC class:

L04AB Tumor necrosis factor alpha (TNF-alpha) inhibitors 4 drugs
adalimumabcertolizumab pegolgolimumabinfliximab

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Psoriasis with arthropathy indication 33339001
Rheumatoid arthritis indication 69896004 DOID:7148
Plaque psoriasis indication 200965009
Juvenile idiopathic arthritis indication 410502007
Nonradiographic axial spondyloarthritis indication 713777005
Sepsis contraindication 91302008




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Tumor necrosis factor Cytokine INHIBITOR DRUG LABEL DRUG LABEL

External reference:

IDSource
OP401G7OJC UNII
D00742 KEGG_DRUG
4021136 VUID
N0000148590 NUI
4021136 VANDF
C0717758 UMLSCUI
CHEBI:4875 CHEBI
CHEMBL1201572 ChEMBL_ID
DB00005 DRUGBANK_ID
D000068800 MESH_DESCRIPTOR_UI
7783 INN_ID
6789 IUPHAR_LIGAND_ID
2103480 RXNORM
13915 MMSL
33391 MMSL
7788 MMSL
d04365 MMSL
007673 NDDF
016975 NDDF
118259007 SNOMEDCT_US
387045004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 50090-3531 SOLUTION 50 mg SUBCUTANEOUS BLA 32 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 50090-4490 SOLUTION 50 mg SUBCUTANEOUS BLA 29 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-010 SOLUTION 25 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-021 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-032 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-044 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-055 SOLUTION 25 mg SUBCUTANEOUS BLA 34 sections